Georgian Scientists/ . 4 N 3, 2022 305 Georgian Scientists Vol. 4 Issue 4, 2022 https://doi.org/10.52340/gs.2022.04.04.34 Delphinium flexuosum Bieb. , 1, 2 1 , , , , 2 , , , Delphinium flexuosum Bieb.- - . GC/MS , . : , , . : , . D. flexuosum , , ; . , ; , ; , . , . , , - . , Georgian Scientists/ . 4 N 3, 2022 306 , . Delphinium L. , , , , [3,4,5,6]. , ( ) , , , [7,8]. , . , Delphinium L.- . 18 [1,2]; Delphinium flexuosum Bieb., . , GC/MS , . : , , . : , , [9,10,11 ]. D. flexuosum- , , , . , 60-150 . - , 3 ; , ; , . , ; [1]. D. flexuosum , . Georgian Scientists/ . 4 N 3, 2022 307 : - Delphinium flexuosum, , . . D. flexuosum ; , N 41.718850 E043.539600, N41.719430 E043.538760, H-1873 m- , 2020-2021 . . PH- 21405 ( . 2). , , 24 . Carl Zeiss, Jeneval- ; (Canon Digital IXUS75) Adobe Photoshop CS5 - . . . D. flexuosum , . . , , .2). 1. D. flexuosum- Georgian Scientists/ . 4 N 3, 2022 308 , , . . . , . . , . , . D. flexuosum , , ( .2). . D. flexuosum ; , ; ; , , , ( .2). 2. D. flexuosum A. B. ; C. ; B. ; E. ; F. , 1. , ; 2. , 3. 4. ; 5. ; 6. 7. ; 8. ; 9. ; 10. . D. flexuosum , . , A B 1 1 2 3 4 C D E F 5 5 6 7 8 9 1 Georgian Scientists/ . 4 N 3, 2022 309 - . ; , , , , , ( .3). D. flexuosum , , , ; , ( .3). ; , . D. flexuosum ; , . , . , - , - - . D. flexuosum - , - .3). 3. D. flexuosum - A. ; B. A B C D1 2 3 4 5 6 7 8 9 1 1 10 Georgian Scientists/ . 4 N 3, 2022 310 ; C. ; D. 1. ; 2. ; 3. ; 4. ; 5. ; 6. ; 7. ; 8. ; 9. ; 10. 11. ). D. flexuosum , . . . , , , . , , . , , . , ( ) . 2-3 , . , . , ; ; , , . . ( .4). 4. D. flexuosum - ( ) A. ; B. . 1. ; 2. ; 3. ; 4. ; 5. ; 6. ; 7; 8. A B 1 23 45 6 7 8 Georgian Scientists/ . 4 N 3, 2022 311 . D. flexuosum , . . , , , , ( .5). , . , . - - . - - - , - ( . 5). 5. D. flexuosum A. ; B. C. - ; D. E. ; F. ; G. A B C 1 2 3 45 7 8 D E F G 9 1 1 1 12 1 5 14 15 16 1 Georgian Scientists/ . 4 N 3, 2022 312 1. ; 2. ; 3. ; 4. ; 5. ; 6. ; 7. 8. ; 9. ; 10. ; 11. ; 12. ; 13. ; 14. ; 15. ; 16. ; 17. . Delphinium flexuosum Bieb.- , . D. Flexuosum- : D. flexuosum , , ; ; D. flexuosum , ; D. flexuosum , - , ; D. flexuosum , ; D. flexuosum : , ; ; ; D. flexuosum , , . Georgian Scientists/ . 4 N 3, 2022 313 : 1. , II, „ “, , 1973, . 40- 51; 2. , “ “, , 2018, . 155-156; 3. Faridi B., Zello A., Touati D., Alaoui K., Cherrah Y. Toxicite aigue et activite anti-in ammatoire des grains de Delphinium staphysagria, Phytotherapie, 2014, 12, pp. 175–180; 4. Xu T.F., Liu S., Meng L.L., Pi Z.F., Liu Z.Q. Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines. J. Chromatogr. B. 2016, 1026, 56–66; 5. Wang J.L., Shen X.L., Chen Q.H., Wang W., Wang F.P. Structure-analgesic activity relationship studies on the C18-and C19-diterpenoid alkaloids. Chem. Pharm. Bull. 2009, 57, 801–807; 6. Liu F., Yang C.H., Liang, J.Y., Liu J.H. Advances in the studies on the pharmacological activities and toxicities of C19 diterpenoid alkaloids. Strait Pharm. J., 2012, 24, pp. 1–5; 7. . . . , 1959, 1, . 38-42; 8. . . , . , 1952, 1, . 43- 51; 9. ., ., ., . , , , , , 1996, 1019 c. 10. Kintsurashvili L. Alkaloids from Delphinium speciosum and Delphinium flexuosum growing in Georgia. International Scientific Practical Symposium “100 YEARS OF SUCCESS AND QUALITY" dedicated to the 100th anniversary of pharmaceutical chemistry department of NUPH Kharkiv, (Ukraine) abstract book. 2021, 18 October p. 61. 11. Kintsurashvili, K. Mulkijanyan, N. Gogitidze, N. Mushkiashvili. Alkaloids from the aerial parts of larkspur (Delphinium speciosum Beeb.) and their pharmacological activity. International Journal of Pharmacy and Pharmaceutical Research, 2020, 18, 4, pp. 204-211. Georgian Scientists/ . 4 N 3, 2022 314 MICROSTRUCTURAL FEATURES OF THE VEGETATIVE ORGANS OF DELPHIUM FLEXUOSUM BIEB. COMMON IN GEORGIA Lali Kintsurashvili, Ketevan Mchedlidze Tbilisi State Medical University I.Kutateladze Institute of Phamacochemistry, Tbilisi, Georgia SUMMARY The genus Delphinium L. is rich in diterpene alkaloids, which exhibit a pronounced curare-like, anti-tumor, anti-inflammatory, analgesic, antidote and insecticidal action. The content of diterpene alkaloids in the aboveground and unde-ground vegetative organs of Delphinium flexuosum Bieb., a promising medicinal plant of the flora of Georgia, and diagnostic features of the internal structure were studied in order to determine the identity of the experimental raw material. GC/MS analysis revealed that the dominant alkaloid obtained from the vegetative organs of the plant is the pharmacologically active methyllicaconitine. Other alkaloids have been identified as anthranoillocytonine, delcosine, lycotonine. As well, the underground organs contain also zongorine, delectine and norzongoramine. A set of diagnostic features of the internal structure of D. flexuosum was determined using the methods adopted in microtechnics. The leaf of D. flexuosum is bifacial, hypostomatic and has dorsoventral structure. It is very rarely covered with long conical trichomes, the underlying cells of the lower and upper epidermis of the leaf are non-wrinkled and curved. The differential stomatal apparatus in leaf-covering tissue is anomocytic. Stomata are lenticular, and structure of the stomata is chaotic, in terms of the reciprocal location of the locking cells. The leaf pulp is differentiated into open, reverse-collateral conductive cones. The aboveground organs of D. flexuosum are characterized by an orderly aligned structural elements of the epidermal tissue, with linear and straight-walled stem cells and orderly arranged anomocytic stomata. Collenchymal and fibrous cells of the mechanical type and open-collateral type conducting cones with a thickening of the spiral and reticular membrane are actively reflected in the organs of the plant axis. The conductive tissue of the root system of D. flexuosum contains a number of polar rays of the wood with differentiated stepwise, spiral and ring-shaped tracheal elements.