Georgian Scientists/ . 5 N 2, 2023 275 Georgian Scientists Vol. 5 Issue 2, 2023 https://doi.org/10.52340/gs.2023.05.02.35 AgNor 1, 2, 3, 4 1 PhD ; 2 PhD ; ; 3 ; ; 4 , ; . , , . , , , . . AgNOR/The Nucleolar Organiser Regions , , . AgNOR- . AgNor . , , . : ; ; ; AgNOR; Georgian Scientists/ . 5 N 2, 2023 276 (1). - , , , . , , , . . , , , , (2). , . , , , (3). , . . . , , , , . . . , . , - , . , . . Crum 1983 , 1999 , , . Georgian Scientists/ . 5 N 2, 2023 277 , , , . , : (1) , (2) (3) . , , 1992 Ward , , , HPV . , , , (4). , . , , , , (2,5). , , . . HPV- , -6 -11 . -17, . , , -17 (1,3). AgNOR/The Nucleolar Organiser Regions , , (6). AgNORs , , 13,14,15,21 22(7). , . (AgNORs) . AgNOR . AgNOR (8). AgNOR- Georgian Scientists/ . 5 N 2, 2023 278 . AgNor . , 2019-2022 . 60 : (20 ), (20 ), (20 ), (20 ). 1: ; 40.0% ; 37.5% - , 22.5% . 2: ; Georgian Scientists/ . 5 N 2, 2023 279 40.55 - 4.04. (H&E) , : 15%- ; 70.0%- ; 85.0%- 75%- . 3: ; AgNOR- ). 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A Review and Update on Papillary Immature Metaplasia of the Uterine Cervix: A Distinct Subset of Low-Grade Squamous Intraepithelial Lesion, Proposing a Possible Cell of Origin. Arch Pathol Lab Med. 2018 Aug;142(8):973–81. 2. Hwang LY, Ma Y, Shiboski SC, Farhat S, Jonte J, Moscicki AB. Active squamous metaplasia of the cervical epithelium is associated with subsequent acquisition of human papillomavirus 16 infection among healthy young women. J Infect Dis. 2012 Aug 15;206(4):504–11. Georgian Scientists/ . 5 N 2, 2023 286 3. Mockler D, Escobar-Hoyos LF, Akalin A, Romeiser J, Shroyer AL, Shroyer KR. Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia. Am J Clin Pathol. 2017 Sep 1;148(3):264–73. 4. SVANADZE T, GACHECHILADZE M, BURKADZE G. PROBLEMATIC ISSUES IN THE EVALUATION OF MOLECULAR CHARACTERISTICS AND POTENTIAL NEOPLASTIC TRANSFORMATION OF CERVICAL METAPLASIA. EXPERIMENTAL & CLINICAL MEDICINE GEORGIA. 2021 Oct 11; 5. Giroux V, Rustgi AK. 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Available from: https://journals.4science.ge/index.php/GS/article/view/1567 Assessment of proliferative activity of different types of squamous cell metaplasia of the cervix using AgNor technology Tamar Svanadze1, Shota Kepuladze2, Nino Tevzadze3, Giorgi Burkadze4 1Phd Student at Tbilisi State Medical Universiy; 2Phd Student at Tbilisi State Medical Universiy, MD, Clinical Pathologist; ORCID: https://orcid.org/0000-0002-5919-5581 3Resident at Tbilisi State Medical Universiy, MD; 4Professor at Tbilisi State Medical University, Head of the Department of Molecular pathology https://orcid.org/0000-0002-5028-4537 Abstract Metaplastic processes represent the transformation of one type of cell into another type within the same tissue. It belongs to the group of adaptive-compensatory processes that develop in response to changed environmental conditions, hormonal stimulation or the development of inflammatory processes. Because its development is directly or indirectly accompanied by the tumorogenesis, they Georgian Scientists/ . 5 N 2, 2023 287 are considered as a pre-cancer condition with different potential for malignancy. The type of metaplasia depends on the type of target tissue itself. AgNOR/The Nucleolar Organizer Regions stands for Nucleolar Organizer Regions and are loops of DNA that project beneath the nucleolars of mitotic interphase nuclei. Increased amounts of AgNOR are associated with increased cell proliferation. The aim of the study was to evaluate the proliferative activity of different types of metaplasias of the cervix using AgNor technology. Based on the results of our research, we can assume that the mentioned technology can be used in routine practice as an aid to evaluate proliferative activity during cervical metaplastic processes. Keywords: cervix; metaplasia; proliferative activity; AgNOR;