Georgian Scientists/ . 5  N 2, 2023 307

Georgian Scientists

Vol. 5  Issue 2, 2023

https://doi.org/10.52340/gs.2023.05.02.39

1, 2, 3

1

; 2 ; 3

. 
,  (Lipoid, ), 

(Sigma-Aldrich, ), : 1:50:10 
. 

 500C . 
, 

. 
, 

 5 .  
 (1400 )  0,2

 (Whatman, ).
 ( , 

).
  

.
-

.
. 

 3 .  N1 .



Georgian Scientists/ . 5  N 2, 2023 308

 N1

1 2 3

-

, 
210±10 315±17 460±20

,
-(21,4±1,0) -(25,2±1,3) -(22,9±1,6)

, 
145±8 1860±12 174±18

,
-(17,9±1,4) -(20,0±1,5) -(19,1±1,3)

N1  ,  
. , 

. 
 190  163 .



Georgian Scientists/ . 5  N 2, 2023 309

 N1. 

. N1) , . 
, , , 

. , 
, ,  140-210 . ,

, 
, 

. .

.
 4  :

1.

125  100 ,  25 
, .

2.  ( ) 
200  125  188 ( -

),  50 
, .

3. 
 (100 ) 

 5 . 
 188- .



Georgian Scientists/ . 5  N 2, 2023 310

4. 
   (1400 ).

 ( , ).

.

.
.  ( ) 

 4 .  N2 .
 N2

1 2 3 4

-
-
-

-
-
-

,
230±16 136±12 255±20 346±24

-
, 

-(7,6±1,4) -(4,6±1,2) -(8,3±1,6) -(12,4±1,8)

-
,

210±9 125±7 235±10 290±15

-
, 

-(6,5±1,5) -(4,0±1,0) -(7,1±1,2) -(8,7±1,5)



Georgian Scientists/ . 5  N 2, 2023 311

 N2. 

 ( .N2) . 
, , , 

. ,  200-230 .

:

Dmitreva M., Shprak Z., Orlova O., Ignatyeva E., Lantsova A., Nikolaeva L., Krasniuk I. Selection of
the composition of a liposomal dosage form of a Russian somatostatin analogue with antitumor
activity. International journal of applied pharmaceutics. 2020:12(6):65-68