Georgian Scientists/ . 7 N 4, 2025 515 Georgian Scientists Vol. 7 Issue 4, 2025 https://doi.org/10.52340/gs.2025.07.04.35 , , 1, 2, 1, 3, 1, 4, 1, 5, 1, 1. 1 , ; 2 “, ; 3 , ; 4 ; 5 „ “ COVID - 19- , , . , , , , , SARS-CoV-2 PCR . , CRP- D-dimer- , , COVID- 19- . - ; , CT . - , , , . , , „ “ : Georgian Scientists/ . 7 N 4, 2025 516 , - . SARS-CoV-2 , , . , . „ “ . Viruses - 2023 -COVID-19 , , , , , . [1, 2, 5] , ( DLCO) COVID-19 30-80%- , , . . [2, 4, 6] . , -COVID , . Monaldi Archives- , 35 65%- , 60%- - , 45%- - , 28%- , . [3] Niyatiwatchanchai , , , , , , , , . [4] -4 -8 , 3- 6 . 600- , 12 79% , , - , . [6] Georgian Scientists/ . 7 N 4, 2025 517 : >50 , , CT , , BIPAP/NIV- . - , , - . [2, 4, 8] COVID-19- , , ; , , . [4] . CRP „ , “ . CRP, - , . , , . , , CRP- , -COVID . [2, 4] D-dimer . D-dimer , , . , D-dimer- . [1, 2] (NLR)- , . COVID- 19- NLR , . NLR CRP, , -COVID , . [4] Georgian Scientists/ . 7 N 4, 2025 518 -Frontiers in Immunology- , „ “ , . CD4+ CD8+ T , , , . [2, 5] : - , . COVID-19 , , , 10.3% . 59.5%- , , . [4] - - , 35 - COVID , , 34%- , 17 , , CT , : ( 53%), . , . [3] -600- , CT : , 12 . , , , . [2, 4, 6] - 4-8 ( Swiss COVID-lung study ), , , , . , . , Georgian Scientists/ . 7 N 4, 2025 519 , , , , [2, 7, 10]. . CT . 12 77.5% , (43.3%). . >50 . Patil- 50 , . [4, 6, 7, 9] ( , , ) , . , . , , , ( . COPD, ) . [3, 8] . Niyatiwatchanchai- , . [4] . : , (1-3 ), -COVID . [2-4, 6-9] ( <100), . [3, 8] , : , - 4 12 , , PCR- . [1, 2, 4, 8] (single-cell, cytokine panel, autoantibody profile) Georgian Scientists/ . 7 N 4, 2025 520 . [2, 4, 6, 10] , , „ “, , .[1, 5] , COVID-19- , , . , , . , , COVID-19 , 8-12 : , , , 6- - . , . CT , >50 „ “ , . , , , , , , . , , , , , , . Georgian Scientists/ . 7 N 4, 2025 521 : 1. Yan, M. Z., Yang, M., & Lai, C.-L. (2023). Post-COVID-19 syndrome comprehensive assessment: From clinical diagnosis to imaging and biochemical-guided management. Viruses, 15(533), 1-26. https://doi.org/10.3390/v15020533 2. Behera, N., Patra, J. K., Dash, B. K., Pattnaik, M., Sahu, D., & Reddy, B. R. (2024). Clinico-radiological and pulmonary function assessment of post-COVID-19 patients with respiratory symptoms. Journal of Family Medicine and Primary Care, 13(8), 2912-2920. 3. Goel, N., et al. (2021). Clinico-radiological evaluation of post-COVID-19 at follow-up. Monaldi Archives for Chest Disease, 91(1682), 386-392. 4. Niyatiwatchanchai, N., Deesomchok, A., Chaiwong, W., Duangjit, P., Pothirat, C., Liwsrisakun, C., ... Srisuwan, T. (2022). Comparative study of early impacts of post- COVID-19 pneumonia on clinical manifestations, pulmonary function, and chest radiographs. Medicina, 58(2), 216. https://doi.org/10.3390/medicina58020216 5. Mehta, P., Sanz-Magallón Duque de Estrada, B., Denneny, E. K., Foster, K., Turner, C. T., Mayer, A., … Tomlinson, G. S. (2024). Single-cell analysis of bronchoalveolar cells in inflammatory and fibrotic post-COVID lung disease. Frontiers in Immunology, 15, 1372658. https://doi.org/10.3389/fimmu.2024.1372658 6. Patil, S., Patil, R., & Gondhali, G. (2022). Pulmonary functions assessment in post- COVID-19 pneumonia cases by spirometry: Study of 600 cases. Journal of Applied Sciences and Clinical Practice, 4(2), 94-100. 7. Disawal, A. (2022). Impact of post-COVID pulmonary sequelae in deciding radiological outcome: An observational study. (pp. 1-4). 8. Husain, M. A., Singh, G. V., Kumar, S., Gupta, P., & Gupta, S. K. (2023). To study clinical and radiological changes in post-COVID-19 patients and its impact on quality of life. International Journal of Science and Research, 12(8), 1-8. 9. Konopkina, L. I., & Rybalka, K. V. (2024). Clinical, functional and imaging parallels in patients after community-acquired COVID-19-associated pneumonia. Infusion & Chemotherapy, 1, 31-38. 10. Chohan, A., Choudhury, S., Dadhwal, R., Vakil, A. P., Franco, R., & Taweesedt, P. T. (2022). Follow-up computed tomography scan in post-COVID-19 pneumonia. World Journal of Radiology, 14(4), 70-106. Georgian Scientists/ . 7 N 4, 2025 522 Evaluation of Clinical, Laboratory, and Imaging Progression and Prognostic Outcomes in Patients with Post-COVID-19 Pneumonia Literature Review Marina Kuparadze¹, ², Giorgi Imedashvili¹, ³, Nino Gegeshidze1, 4, Xatuna Chaava1, 5, Mariam Morchiladze¹, Tamila Silagadze¹. 1Tbilisi State Medical University, Tbilisi, Georgia; 2Cardiology Clinic "Guli", Tbilisi, Georgia; 3High Technology Medical Center, University Clinic, Tbilisi, Georgia; 4Emergency Neurology Clinic – Neurologist, Tbilisi, Georgia; 5Clinic “Redi”, Tbilisi, Georgia ABSTRACT Post-COVID pneumonia is a lung injury that develops after the acute phase of COVID-19, which is characterized by slowly regressing respiratory symptoms, radiological changes, and impaired lung function. According to existing studies, after several weeks or months of improvement, a significant proportion of patients continue to complain of fatigue, dry cough, and dyspnea, despite the fact that SARS-CoV-2 PCR is already negative. However, a prolonged increase in neutrophil-lymphocyte imbalance, CRP, and D-dimer indicates a background of chronic low-intensity inflammation, and spirometry is dominated by restrictive ventilation disorders and reduced gas diffusion, which is especially evident in cases of severe COVID-19 or acute respiratory distress syndrome. Ground-glass infiltration is still relevant on computed tomography against the background of fibrotic changes; its frequency and extent are determined by the severity of the acute phase, the CT severity index, and the duration of hypoxemia. The prognosis in patients with acute respiratory distress syndrome is worse due to higher fibrotic changes and reduced tolerance to physical activity than in mild cases. An integrated, “triple” assessment is important for the interpretation of the final diagnosis, treatment tactics, and prognosis: a joint analysis of clinical, laboratory, and radiological data - for the purpose of identifying high-risk patients and further monitoring.