id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
gra-901	Sharma, Smita; Dagrer, Rami Abdullah Ali Al; Mathur, S k; Maheshwari, Ramesh; Kharab, Simmi	ROLE OF UNFOLDED PROTEIN RESPONSE IN CARDIAC DISEASES.	2020	2	.pdf	application/pdf	1604	95	46	Increased Production of Proteins Involved in the Functions of the UPR UPR activation also results in upregulation of proteins involved in chaperoning malfolding proteins, protein folding and ERAD, including further production of Grp78. An alternative model has been proposed, whereby unfolded proteins interact directly with the ER- lumenal domain of Ire1, causing oligomerization and transautophosphorylation.[2] THE INITIAL PHASES OF UPR ACTIVATION HAVE TWO KEY ROLES: Translation Attenuation and Cell Cycle Arrest by the PERK Receptor This occurs within minutes to hours of UPR activation to prevent further translational loading of the ER.	cache/gra-901.pdf	txt/gra-901.txt