id	sid	tid	token	lemma	pos
gra-2156	1	1	13.bluetree.cdr	13.bluetree.cdr	NUM
gra-2156	1	2	type	type	NOUN
gra-2156	1	3	2	2	NUM
gra-2156	1	4	diabetes	diabetes	NOUN
gra-2156	1	5	mellitus	mellitus	NOUN
gra-2156	1	6	(	(	PUNCT
gra-2156	1	7	t2	t2	NOUN
gra-2156	1	8	dm	dm	NOUN
gra-2156	1	9	)	)	PUNCT
gra-2156	1	10	is	be	AUX
gra-2156	1	11	characterized	characterize	VERB
gra-2156	1	12	by	by	ADP
gra-2156	1	13	relative	relative	ADJ
gra-2156	1	14	insulin	insulin	NOUN
gra-2156	1	15	deciency	deciency	NOUN
gra-2156	1	16	,	,	PUNCT
gra-2156	1	17	decreased	decrease	VERB
gra-2156	1	18	peripheral	peripheral	ADJ
gra-2156	1	19	and	and	CCONJ
gra-2156	1	20	hepatic	hepatic	ADJ
gra-2156	1	21	1sensitivity	1sensitivity	NUM
gra-2156	1	22	to	to	ADP
gra-2156	1	23	insulin	insulin	NOUN
gra-2156	1	24	and	and	CCONJ
gra-2156	1	25	raised	raise	VERB
gra-2156	1	26	plasma	plasma	NOUN
gra-2156	1	27	glucose	glucose	NOUN
gra-2156	1	28	levels	level	NOUN
gra-2156	1	29	.	.	PUNCT
gra-2156	2	1	t2	t2	NOUN
gra-2156	2	2	dm	dm	PROPN
gra-2156	2	3	treatment	treatment	NOUN
gra-2156	2	4	begins	begin	VERB
gra-2156	2	5	with	with	ADP
gra-2156	2	6	lifestyle	lifestyle	NOUN
gra-2156	2	7	interventions	intervention	NOUN
gra-2156	2	8	,	,	PUNCT
gra-2156	2	9	before	before	ADP
gra-2156	2	10	progressing	progress	VERB
gra-2156	2	11	to	to	ADP
gra-2156	2	12	pharmacological	pharmacological	ADJ
gra-2156	2	13	interventions	intervention	NOUN
gra-2156	2	14	with	with	ADP
gra-2156	2	15	advancing	advance	VERB
gra-2156	2	16	disease	disease	NOUN
gra-2156	2	17	.	.	PUNCT
gra-2156	3	1	despite	despite	SCONJ
gra-2156	3	2	the	the	DET
gra-2156	3	3	introduction	introduction	NOUN
gra-2156	3	4	of	of	ADP
gra-2156	3	5	numerous	numerous	ADJ
gra-2156	3	6	antihyperglycemic	antihyperglycemic	ADJ
gra-2156	3	7	medications	medication	NOUN
gra-2156	3	8	,	,	PUNCT
gra-2156	3	9	many	many	ADJ
gra-2156	3	10	patients	patient	NOUN
gra-2156	3	11	with	with	ADP
gra-2156	3	12	t2	t2	NOUN
gra-2156	3	13	dm	dm	AUX
gra-2156	3	14	require	require	VERB
gra-2156	3	15	insulin	insulin	NOUN
gra-2156	3	16	,	,	PUNCT
gra-2156	3	17	and	and	CCONJ
gra-2156	3	18	basal	basal	ADJ
gra-2156	3	19	insulin	insulin	NOUN
gra-2156	3	20	continues	continue	VERB
gra-2156	3	21	to	to	PART
gra-2156	3	22	be	be	AUX
gra-2156	3	23	frequently	frequently	ADV
gra-2156	3	24	used	use	VERB
gra-2156	3	25	either	either	CCONJ
gra-2156	3	26	as	as	ADP
gra-2156	3	27	rst	rst	NOUN
gra-2156	3	28	-	-	PUNCT
gra-2156	3	29	line	line	NOUN
gra-2156	3	30	insulin	insulin	NOUN
gra-2156	3	31	treatment	treatment	NOUN
gra-2156	3	32	or	or	CCONJ
gra-2156	3	33	as	as	ADP
gra-2156	3	34	part	part	NOUN
gra-2156	3	35	of	of	ADP
gra-2156	3	36	multiple	multiple	ADJ
gra-2156	3	37	daily	daily	ADJ
gra-2156	3	38	2injection	2injection	NUM
gra-2156	3	39	regimens	regimen	NOUN
gra-2156	3	40	.	.	PUNCT
gra-2156	4	1	oral	oral	ADJ
gra-2156	4	2	hypoglycemic	hypoglycemic	ADJ
gra-2156	4	3	agents	agent	NOUN
gra-2156	4	4	are	be	AUX
gra-2156	4	5	effective	effective	ADJ
gra-2156	4	6	agents	agent	NOUN
gra-2156	4	7	for	for	ADP
gra-2156	4	8	diabetes	diabetes	NOUN
gra-2156	4	9	management	management	NOUN
gra-2156	4	10	,	,	PUNCT
gra-2156	4	11	although	although	SCONJ
gra-2156	4	12	secondary	secondary	ADJ
gra-2156	4	13	drug	drug	NOUN
gra-2156	4	14	failure	failure	NOUN
gra-2156	4	15	rates	rate	NOUN
gra-2156	4	16	of	of	ADP
gra-2156	4	17	5	5	NUM
gra-2156	4	18	-	-	SYM
gra-2156	4	19	10	10	NUM
gra-2156	4	20	%	%	NOUN
gra-2156	4	21	are	be	AUX
gra-2156	4	22	bothersome	bothersome	ADJ
gra-2156	4	23	.	.	PUNCT
gra-2156	5	1	the	the	DET
gra-2156	5	2	disappointing	disappointing	ADJ
gra-2156	5	3	results	result	NOUN
gra-2156	5	4	with	with	ADP
gra-2156	5	5	monotherapy	monotherapy	NOUN
gra-2156	5	6	especially	especially	ADV
gra-2156	5	7	the	the	DET
gra-2156	5	8	worsening	worsen	VERB
gra-2156	5	9	metabolic	metabolic	NOUN
gra-2156	5	10	control	control	NOUN
gra-2156	5	11	is	be	AUX
gra-2156	5	12	often	often	ADV
gra-2156	5	13	seen	see	VERB
gra-2156	5	14	within	within	ADP
gra-2156	5	15	ve	ve	PROPN
gra-2156	5	16	years	year	NOUN
gra-2156	5	17	after	after	ADP
gra-2156	5	18	the	the	DET
gra-2156	5	19	initiation	initiation	NOUN
gra-2156	5	20	of	of	ADP
gra-2156	5	21	an	an	DET
gra-2156	5	22	oral	oral	ADJ
gra-2156	5	23	hypoglycemic	hypoglycemic	ADJ
gra-2156	5	24	agent	agent	NOUN
gra-2156	5	25	,	,	PUNCT
gra-2156	5	26	with	with	ADP
gra-2156	5	27	more	more	ADJ
gra-2156	5	28	than	than	ADP
gra-2156	5	29	50	50	NUM
gra-2156	5	30	%	%	NOUN
gra-2156	5	31	patients	patient	NOUN
gra-2156	5	32	requiring	require	VERB
gra-2156	5	33	shifting	shift	VERB
gra-2156	5	34	to	to	ADP
gra-2156	5	35	the	the	DET
gra-2156	5	36	insulin	insulin	NOUN
gra-2156	5	37	-	-	PUNCT
gra-2156	5	38	based	base	VERB
gra-2156	5	39	regimen	regiman	NOUN
gra-2156	5	40	to	to	PART
gra-2156	5	41	achieve	achieve	VERB
gra-2156	5	42	3optimal	3optimal	NUM
gra-2156	5	43	glycaemic	glycaemic	ADJ
gra-2156	5	44	control	control	NOUN
gra-2156	5	45	.	.	PUNCT
gra-2156	6	1	basal	basal	ADJ
gra-2156	6	2	insulin	insulin	NOUN
gra-2156	6	3	therapy	therapy	NOUN
gra-2156	6	4	is	be	AUX
gra-2156	6	5	recommended	recommend	VERB
gra-2156	6	6	if	if	SCONJ
gra-2156	6	7	lifestyle	lifestyle	NOUN
gra-2156	6	8	modications	modication	NOUN
gra-2156	6	9	and	and	CCONJ
gra-2156	6	10	oral	oral	ADJ
gra-2156	6	11	antidiabetic	antidiabetic	ADJ
gra-2156	6	12	agents	agent	NOUN
gra-2156	6	13	fail	fail	VERB
gra-2156	6	14	to	to	PART
gra-2156	6	15	maintain	maintain	VERB
gra-2156	6	16	hba1c	hba1c	PROPN
gra-2156	6	17	levels	level	NOUN
gra-2156	6	18	<	<	X
gra-2156	6	19	7.5	7.5	NUM
gra-2156	6	20	%	%	NOUN
gra-2156	6	21	and	and	CCONJ
gra-2156	6	22	has	have	AUX
gra-2156	6	23	been	be	AUX
gra-2156	6	24	4shown	4shown	NUM
gra-2156	6	25	to	to	PART
gra-2156	6	26	improve	improve	VERB
gra-2156	6	27	glycemic	glycemic	ADJ
gra-2156	6	28	control	control	NOUN
gra-2156	6	29	.	.	PUNCT
gra-2156	7	1	this	this	DET
gra-2156	7	2	highlights	highlight	VERB
gra-2156	7	3	the	the	DET
gra-2156	7	4	fact	fact	NOUN
gra-2156	7	5	that	that	SCONJ
gra-2156	7	6	adequate	adequate	ADJ
gra-2156	7	7	basal	basal	ADJ
gra-2156	7	8	insulin	insulin	NOUN
gra-2156	7	9	levels	level	NOUN
gra-2156	7	10	are	be	AUX
gra-2156	7	11	an	an	DET
gra-2156	7	12	essential	essential	ADJ
gra-2156	7	13	component	component	NOUN
gra-2156	7	14	of	of	ADP
gra-2156	7	15	diabetes	diabetes	NOUN
gra-2156	7	16	management	management	NOUN
gra-2156	7	17	.	.	PUNCT
gra-2156	8	1	the	the	DET
gra-2156	8	2	ideal	ideal	ADJ
gra-2156	8	3	basal	basal	PROPN
gra-2156	8	4	insulin	insulin	NOUN
gra-2156	8	5	should	should	AUX
gra-2156	8	6	provide	provide	VERB
gra-2156	8	7	a	a	DET
gra-2156	8	8	sustained	sustained	ADJ
gra-2156	8	9	level	level	NOUN
gra-2156	8	10	of	of	ADP
gra-2156	8	11	insulin	insulin	NOUN
gra-2156	8	12	,	,	PUNCT
gra-2156	8	13	mimicking	mimic	VERB
gra-2156	8	14	physiological	physiological	ADJ
gra-2156	8	15	basal	basal	NOUN
gra-2156	8	16	insulin	insulin	NOUN
gra-2156	8	17	secretion	secretion	NOUN
gra-2156	8	18	,	,	PUNCT
gra-2156	8	19	reproduce	reproduce	VERB
gra-2156	8	20	physiological	physiological	ADJ
gra-2156	8	21	basal	basal	NOUN
gra-2156	8	22	insulin	insulin	NOUN
gra-2156	8	23	secretion	secretion	NOUN
gra-2156	8	24	,	,	PUNCT
gra-2156	8	25	thereby	thereby	ADV
gra-2156	8	26	restoring	restore	VERB
gra-2156	8	27	glycemic	glycemic	ADJ
gra-2156	8	28	control	control	NOUN
gra-2156	8	29	,	,	PUNCT
gra-2156	8	30	without	without	ADP
gra-2156	8	31	1hypoglycemia	1hypoglycemia	NUM
gra-2156	8	32	.	.	PUNCT
gra-2156	9	1	such	such	ADJ
gra-2156	9	2	therapy	therapy	NOUN
gra-2156	9	3	should	should	AUX
gra-2156	9	4	have	have	VERB
gra-2156	9	5	relatively	relatively	ADV
gra-2156	9	6	at	at	ADJ
gra-2156	9	7	/	/	SYM
gra-2156	9	8	constant	constant	ADJ
gra-2156	9	9	insulin	insulin	NOUN
gra-2156	9	10	concentration	concentration	NOUN
gra-2156	9	11	prole	prole	PROPN
gra-2156	9	12	over	over	ADP
gra-2156	9	13	time	time	NOUN
gra-2156	9	14	,	,	PUNCT
gra-2156	9	15	no	no	DET
gra-2156	9	16	pronounced	pronounced	ADJ
gra-2156	9	17	peak	peak	NOUN
gra-2156	9	18	,	,	PUNCT
gra-2156	9	19	duration	duration	NOUN
gra-2156	9	20	of	of	ADP
gra-2156	9	21	action	action	NOUN
gra-2156	9	22	of	of	ADP
gra-2156	9	23	at	at	ADV
gra-2156	9	24	least	least	ADJ
gra-2156	9	25	24	24	NUM
gra-2156	9	26	h	h	NOUN
gra-2156	9	27	,	,	PUNCT
gra-2156	9	28	low	low	ADJ
gra-2156	9	29	within	within	ADP
gra-2156	9	30	-	-	PUNCT
gra-2156	9	31	patient	patient	NOUN
gra-2156	9	32	variability	variability	NOUN
gra-2156	9	33	in	in	ADP
gra-2156	9	34	fasting	fast	VERB
gra-2156	9	35	plasma	plasma	NOUN
gra-2156	9	36	glucose	glucose	NOUN
gra-2156	9	37	(	(	PUNCT
gra-2156	9	38	fpg	fpg	PROPN
gra-2156	9	39	)	)	PUNCT
gra-2156	9	40	,	,	PUNCT
gra-2156	9	41	a	a	DET
gra-2156	9	42	favorable	favorable	ADJ
gra-2156	9	43	safety	safety	NOUN
gra-2156	9	44	prole	prole	PROPN
gra-2156	9	45	,	,	PUNCT
gra-2156	9	46	including	include	VERB
gra-2156	9	47	low	low	ADJ
gra-2156	9	48	risk	risk	NOUN
gra-2156	9	49	of	of	ADP
gra-2156	9	50	hypoglycemia	hypoglycemia	NOUN
gra-2156	9	51	2and	2and	NUM
gra-2156	9	52	weight	weight	NOUN
gra-2156	9	53	gain	gain	NOUN
gra-2156	9	54	,	,	PUNCT
gra-2156	9	55	and	and	CCONJ
gra-2156	9	56	be	be	AUX
gra-2156	9	57	easy	easy	ADJ
gra-2156	9	58	to	to	PART
gra-2156	9	59	administer	administer	VERB
gra-2156	9	60	and	and	CCONJ
gra-2156	9	61	titrate	titrate	VERB
gra-2156	9	62	.	.	PUNCT
gra-2156	10	1	however	however	ADV
gra-2156	10	2	,	,	PUNCT
gra-2156	10	3	traditional	traditional	ADJ
gra-2156	10	4	insulin	insulin	NOUN
gra-2156	10	5	does	do	AUX
gra-2156	10	6	not	not	PART
gra-2156	10	7	fully	fully	ADV
gra-2156	10	8	accomplish	accomplish	VERB
gra-2156	10	9	this	this	DET
gra-2156	10	10	goal	goal	NOUN
gra-2156	10	11	.	.	PUNCT
gra-2156	11	1	this	this	PRON
gra-2156	11	2	stimulated	stimulate	VERB
gra-2156	11	3	the	the	DET
gra-2156	11	4	search	search	NOUN
gra-2156	11	5	for	for	ADP
gra-2156	11	6	insulins	insulin	NOUN
gra-2156	11	7	with	with	ADP
gra-2156	11	8	a	a	DET
gra-2156	11	9	more	more	ADV
gra-2156	11	10	prolonged	prolonged	ADJ
gra-2156	11	11	duration	duration	NOUN
gra-2156	11	12	of	of	ADP
gra-2156	11	13	action	action	NOUN
gra-2156	11	14	that	that	PRON
gra-2156	11	15	could	could	AUX
gra-2156	11	16	better	well	ADV
gra-2156	11	17	replicate	replicate	VERB
gra-2156	11	18	the	the	DET
gra-2156	11	19	5physiological	5physiological	PROPN
gra-2156	11	20	basal	basal	NOUN
gra-2156	11	21	insulin	insulin	NOUN
gra-2156	11	22	secretory	secretory	ADJ
gra-2156	11	23	response	response	NOUN
gra-2156	11	24	.	.	PUNCT
gra-2156	12	1	this	this	PRON
gra-2156	12	2	eventually	eventually	ADV
gra-2156	12	3	led	lead	VERB
gra-2156	12	4	to	to	ADP
gra-2156	12	5	the	the	DET
gra-2156	12	6	development	development	NOUN
gra-2156	12	7	of	of	ADP
gra-2156	12	8	basal	basal	ADJ
gra-2156	12	9	insulin	insulin	NOUN
gra-2156	12	10	-	-	PUNCT
gra-2156	12	11	like	like	ADJ
gra-2156	12	12	,	,	PUNCT
gra-2156	12	13	neutral	neutral	ADJ
gra-2156	12	14	(	(	PUNCT
gra-2156	12	15	porcine	porcine	NOUN
gra-2156	12	16	)	)	PUNCT
gra-2156	12	17	protamine	protamine	PROPN
gra-2156	12	18	hagedorn	hagedorn	PROPN
gra-2156	12	19	(	(	PUNCT
gra-2156	12	20	nph	nph	NOUN
gra-2156	12	21	)	)	PUNCT
gra-2156	12	22	insulin	insulin	PROPN
gra-2156	12	23	,	,	PUNCT
gra-2156	12	24	lente	lente	PROPN
gra-2156	12	25	insulin	insulin	PROPN
gra-2156	12	26	,	,	PUNCT
gra-2156	12	27	insulin	insulin	NOUN
gra-2156	12	28	detemir	detemir	NOUN
gra-2156	12	29	,	,	PUNCT
gra-2156	12	30	etc	etc	X
gra-2156	12	31	.	.	X
gra-2156	12	32	still	still	ADV
gra-2156	12	33	,	,	PUNCT
gra-2156	12	34	all	all	DET
gra-2156	12	35	these	these	DET
gra-2156	12	36	variants	variant	NOUN
gra-2156	12	37	are	be	AUX
gra-2156	12	38	also	also	ADV
gra-2156	12	39	not	not	PART
gra-2156	12	40	able	able	ADJ
gra-2156	12	41	to	to	PART
gra-2156	12	42	achieve	achieve	VERB
gra-2156	12	43	the	the	DET
gra-2156	12	44	desired	desire	VERB
gra-2156	12	45	therapeutic	therapeutic	ADJ
gra-2156	12	46	insulin	insulin	NOUN
gra-2156	12	47	levels	level	NOUN
gra-2156	12	48	.	.	PUNCT
gra-2156	13	1	for	for	ADP
gra-2156	13	2	instance	instance	NOUN
gra-2156	13	3	,	,	PUNCT
gra-2156	13	4	nph	nph	PROPN
gra-2156	13	5	insulin	insulin	NOUN
gra-2156	13	6	,	,	PUNCT
gra-2156	13	7	intermediate	intermediate	ADJ
gra-2156	13	8	-	-	PUNCT
gra-2156	13	9	acting	act	VERB
gra-2156	13	10	insulin	insulin	NOUN
gra-2156	13	11	,	,	PUNCT
gra-2156	13	12	has	have	VERB
gra-2156	13	13	a	a	DET
gra-2156	13	14	duration	duration	NOUN
gra-2156	13	15	of	of	ADP
gra-2156	13	16	action	action	NOUN
gra-2156	13	17	that	that	PRON
gra-2156	13	18	is	be	AUX
gra-2156	13	19	considerably	considerably	ADV
gra-2156	13	20	less	less	ADJ
gra-2156	13	21	than	than	ADP
gra-2156	13	22	24	24	NUM
gra-2156	13	23	h	h	NOUN
gra-2156	13	24	and	and	CCONJ
gra-2156	13	25	an	an	DET
gra-2156	13	26	activity	activity	NOUN
gra-2156	13	27	prole	prole	PROPN
gra-2156	13	28	that	that	PRON
gra-2156	13	29	peaks	peak	VERB
gra-2156	13	30	3–5	3–5	NUM
gra-2156	13	31	h	h	NOUN
gra-2156	13	32	after	after	ADP
gra-2156	13	33	administration	administration	NOUN
gra-2156	13	34	.	.	PUNCT
gra-2156	14	1	nph	nph	PROPN
gra-2156	14	2	insulin	insulin	PROPN
gra-2156	14	3	administered	administer	VERB
gra-2156	14	4	at	at	ADP
gra-2156	14	5	bedtime	bedtime	NOUN
gra-2156	14	6	results	result	NOUN
gra-2156	14	7	in	in	ADP
gra-2156	14	8	high	high	ADJ
gra-2156	14	9	insulin	insulin	NOUN
gra-2156	14	10	levels	level	NOUN
gra-2156	14	11	when	when	SCONJ
gra-2156	14	12	insulin	insulin	NOUN
gra-2156	14	13	requirements	requirement	NOUN
gra-2156	14	14	are	be	AUX
gra-2156	14	15	low	low	ADJ
gra-2156	14	16	.	.	PUNCT
gra-2156	15	1	this	this	DET
gra-2156	15	2	activity	activity	NOUN
gra-2156	15	3	prole	prole	PROPN
gra-2156	15	4	is	be	AUX
gra-2156	15	5	not	not	PART
gra-2156	15	6	1ideal	1ideal	NUM
gra-2156	15	7	as	as	SCONJ
gra-2156	15	8	it	it	PRON
gra-2156	15	9	increases	increase	VERB
gra-2156	15	10	the	the	DET
gra-2156	15	11	risk	risk	NOUN
gra-2156	15	12	of	of	ADP
gra-2156	15	13	nocturnal	nocturnal	ADJ
gra-2156	15	14	hypoglycaemia	hypoglycaemia	NOUN
gra-2156	15	15	.	.	PUNCT
gra-2156	16	1	a	a	DET
gra-2156	16	2	greater	great	ADJ
gra-2156	16	3	understanding	understanding	NOUN
gra-2156	16	4	of	of	ADP
gra-2156	16	5	the	the	DET
gra-2156	16	6	protein	protein	NOUN
gra-2156	16	7	structure	structure	NOUN
gra-2156	16	8	of	of	ADP
gra-2156	16	9	insulin	insulin	NOUN
gra-2156	16	10	and	and	CCONJ
gra-2156	16	11	the	the	DET
gra-2156	16	12	roles	role	NOUN
gra-2156	16	13	of	of	ADP
gra-2156	16	14	key	key	ADJ
gra-2156	16	15	amino	amino	NOUN
gra-2156	16	16	acids	acid	NOUN
gra-2156	16	17	has	have	AUX
gra-2156	16	18	opened	open	VERB
gra-2156	16	19	up	up	ADP
gra-2156	16	20	new	new	ADJ
gra-2156	16	21	avenues	avenue	NOUN
gra-2156	16	22	for	for	ADP
gra-2156	16	23	the	the	DET
gra-2156	16	24	rational	rational	ADJ
gra-2156	16	25	design	design	NOUN
gra-2156	16	26	of	of	ADP
gra-2156	16	27	insulin	insulin	NOUN
gra-2156	16	28	analogs	analog	NOUN
gra-2156	16	29	with	with	ADP
gra-2156	16	30	more	more	ADV
gra-2156	16	31	predictable	predictable	ADJ
gra-2156	16	32	absorption	absorption	NOUN
gra-2156	16	33	and	and	CCONJ
gra-2156	16	34	time	time	NOUN
gra-2156	16	35	–	–	PUNCT
gra-2156	16	36	action	action	NOUN
gra-2156	16	37	characteristics	characteristic	NOUN
gra-2156	16	38	.	.	PUNCT
gra-2156	17	1	insulin	insulin	NOUN
gra-2156	17	2	glargine	glargine	NOUN
gra-2156	17	3	(	(	PUNCT
gra-2156	17	4	iglar	iglar	NOUN
gra-2156	17	5	)	)	PUNCT
gra-2156	17	6	was	be	AUX
gra-2156	17	7	the	the	DET
gra-2156	17	8	rst	rst	PROPN
gra-2156	17	9	long	long	ADV
gra-2156	17	10	-	-	PUNCT
gra-2156	17	11	acting	act	VERB
gra-2156	17	12	basal	basal	NOUN
gra-2156	17	13	analog	analog	NOUN
gra-2156	17	14	to	to	PART
gra-2156	17	15	be	be	AUX
gra-2156	17	16	introduced	introduce	VERB
gra-2156	17	17	into	into	ADP
gra-2156	17	18	clinical	clinical	ADJ
gra-2156	17	19	practice	practice	NOUN
gra-2156	17	20	in	in	ADP
gra-2156	17	21	2000	2000	NUM
gra-2156	17	22	and	and	CCONJ
gra-2156	17	23	was	be	AUX
gra-2156	17	24	a	a	DET
gra-2156	17	25	breakthrough	breakthrough	NOUN
gra-2156	17	26	in	in	ADP
gra-2156	17	27	the	the	DET
gra-2156	17	28	eld	eld	NOUN
gra-2156	17	29	of	of	ADP
gra-2156	17	30	insulin	insulin	NOUN
gra-2156	17	31	therapy	therapy	NOUN
gra-2156	17	32	.	.	PUNCT
gra-2156	18	1	it	it	PRON
gra-2156	18	2	continues	continue	VERB
gra-2156	18	3	to	to	PART
gra-2156	18	4	be	be	AUX
gra-2156	18	5	a	a	DET
gra-2156	18	6	gold	gold	ADJ
gra-2156	18	7	standard	standard	NOUN
gra-2156	18	8	of	of	ADP
gra-2156	18	9	basal	basal	ADJ
gra-2156	18	10	insulin	insulin	NOUN
gra-2156	18	11	treatment	treatment	NOUN
gra-2156	18	12	and	and	CCONJ
gra-2156	18	13	a	a	DET
gra-2156	18	14	benchmark	benchmark	NOUN
gra-2156	18	15	for	for	ADP
gra-2156	18	16	new	new	ADJ
gra-2156	18	17	injectable	injectable	ADJ
gra-2156	18	18	antihyperglycemic	antihyperglycemic	ADJ
gra-2156	18	19	treatments	treatment	NOUN
gra-2156	18	20	,	,	PUNCT
gra-2156	18	21	including	include	VERB
gra-2156	18	22	newer	new	ADJ
gra-2156	18	23	basal	basal	ADJ
gra-2156	18	24	insulin	insulin	NOUN
gra-2156	18	25	2analogs	2analogs	NUM
gra-2156	18	26	.	.	PUNCT
gra-2156	19	1	iglar	iglar	ADJ
gra-2156	19	2	is	be	AUX
gra-2156	19	3	a	a	DET
gra-2156	19	4	biosynthetic	biosynthetic	ADJ
gra-2156	19	5	,	,	PUNCT
gra-2156	19	6	long	long	ADV
gra-2156	19	7	-	-	PUNCT
gra-2156	19	8	acting	act	VERB
gra-2156	19	9	,	,	PUNCT
gra-2156	19	10	clear	clear	ADJ
gra-2156	19	11	human	human	ADJ
gra-2156	19	12	insulin	insulin	NOUN
gra-2156	19	13	analogue	analogue	NOUN
gra-2156	19	14	with	with	ADP
gra-2156	19	15	an	an	DET
gra-2156	19	16	acidic	acidic	ADJ
gra-2156	19	17	ph	ph	NOUN
gra-2156	19	18	.	.	NOUN
gra-2156	19	19	upon	upon	SCONJ
gra-2156	19	20	subcutaneous	subcutaneous	ADJ
gra-2156	19	21	injection	injection	NOUN
gra-2156	19	22	,	,	PUNCT
gra-2156	19	23	iglar	iglar	NOUN
gra-2156	19	24	is	be	AUX
gra-2156	19	25	neutralized	neutralize	VERB
gra-2156	19	26	and	and	CCONJ
gra-2156	19	27	forms	form	VERB
gra-2156	19	28	microprecipitates	microprecipitate	NOUN
gra-2156	19	29	that	that	SCONJ
gra-2156	19	30	6release	6release	NUM
gra-2156	19	31	insulin	insulin	NOUN
gra-2156	19	32	in	in	ADP
gra-2156	19	33	a	a	DET
gra-2156	19	34	constant	constant	ADJ
gra-2156	19	35	prole	prole	PROPN
gra-2156	19	36	over	over	ADP
gra-2156	19	37	24	24	NUM
gra-2156	19	38	h	h	NOUN
gra-2156	19	39	.	.	PUNCT
gra-2156	20	1	structure	structure	NOUN
gra-2156	20	2	of	of	ADP
gra-2156	20	3	iglar	iglar	ADJ
gra-2156	20	4	iglar	iglar	NOUN
gra-2156	20	5	differs	differ	VERB
gra-2156	20	6	from	from	ADP
gra-2156	20	7	human	human	ADJ
gra-2156	20	8	insulin	insulin	NOUN
gra-2156	20	9	by	by	ADP
gra-2156	20	10	the	the	DET
gra-2156	20	11	replacement	replacement	NOUN
gra-2156	20	12	of	of	ADP
gra-2156	20	13	a21	a21	PROPN
gra-2156	20	14	asparagine	asparagine	NOUN
gra-2156	20	15	with	with	ADP
gra-2156	20	16	glycine	glycine	NOUN
gra-2156	20	17	and	and	CCONJ
gra-2156	20	18	the	the	DET
gra-2156	20	19	addition	addition	NOUN
gra-2156	20	20	of	of	ADP
gra-2156	20	21	two	two	NUM
gra-2156	20	22	arginine	arginine	NOUN
gra-2156	20	23	residues	residue	NOUN
gra-2156	20	24	at	at	ADP
gra-2156	20	25	b31	b31	NOUN
gra-2156	20	26	and	and	CCONJ
gra-2156	20	27	b32	b32	PROPN
gra-2156	20	28	(	(	PUNCT
gra-2156	20	29	glya21	glya21	NOUN
gra-2156	20	30	,	,	PUNCT
gra-2156	20	31	argb31	argb31	NOUN
gra-2156	20	32	,	,	PUNCT
gra-2156	20	33	and	and	CCONJ
gra-2156	20	34	argb32	argb32	PROPN
gra-2156	20	35	)	)	PUNCT
gra-2156	20	36	.	.	PUNCT
gra-2156	21	1	these	these	DET
gra-2156	21	2	mutations	mutation	NOUN
gra-2156	21	3	endow	endow	NOUN
gra-2156	21	4	glargine	glargine	NOUN
gra-2156	21	5	with	with	ADP
gra-2156	21	6	an	an	DET
gra-2156	21	7	isoelectric	isoelectric	ADJ
gra-2156	21	8	point	point	NOUN
gra-2156	21	9	of	of	ADP
gra-2156	21	10	6.4–6.8	6.4–6.8	NOUN
gra-2156	21	11	,	,	PUNCT
gra-2156	21	12	implying	imply	VERB
gra-2156	21	13	that	that	SCONJ
gra-2156	21	14	it	it	PRON
gra-2156	21	15	is	be	AUX
gra-2156	21	16	easily	easily	ADV
gra-2156	21	17	soluble	soluble	ADJ
gra-2156	21	18	at	at	ADP
gra-2156	21	19	acid	acid	NOUN
gra-2156	21	20	ph	ph	NOUN
gra-2156	21	21	and	and	CCONJ
gra-2156	21	22	less	less	ADV
gra-2156	21	23	soluble	soluble	ADJ
gra-2156	21	24	at	at	ADP
gra-2156	21	25	neutral	neutral	ADJ
gra-2156	21	26	ph	ph	PROPN
gra-2156	21	27	.	.	PROPN
gra-2156	21	28	as	as	ADP
gra-2156	21	29	a	a	DET
gra-2156	21	30	result	result	NOUN
gra-2156	21	31	,	,	PUNCT
gra-2156	21	32	upon	upon	SCONJ
gra-2156	21	33	subcutaneous	subcutaneous	ADJ
gra-2156	21	34	injection	injection	NOUN
gra-2156	21	35	,	,	PUNCT
gra-2156	21	36	iglar	iglar	NOUN
gra-2156	21	37	forms	form	VERB
gra-2156	21	38	an	an	DET
gra-2156	21	39	amorphous	amorphous	ADJ
gra-2156	21	40	precipitate	precipitate	NOUN
gra-2156	21	41	in	in	ADP
gra-2156	21	42	the	the	DET
gra-2156	21	43	subcutaneous	subcutaneous	ADJ
gra-2156	21	44	tissue	tissue	NOUN
gra-2156	21	45	,	,	PUNCT
gra-2156	21	46	which	which	PRON
gra-2156	21	47	slowly	slowly	ADV
gra-2156	21	48	dissociates	dissociate	VERB
gra-2156	21	49	,	,	PUNCT
gra-2156	21	50	providing	provide	VERB
gra-2156	21	51	a	a	DET
gra-2156	21	52	sustained	sustained	ADJ
gra-2156	21	53	release	release	NOUN
gra-2156	21	54	of	of	ADP
gra-2156	21	55	5insulin	5insulin	NUM
gra-2156	21	56	into	into	ADP
gra-2156	21	57	the	the	DET
gra-2156	21	58	circulation	circulation	NOUN
gra-2156	21	59	.	.	PUNCT
gra-2156	22	1	once	once	ADV
gra-2156	22	2	injected	inject	VERB
gra-2156	22	3	,	,	PUNCT
gra-2156	22	4	iglar	iglar	NOUN
gra-2156	22	5	gets	get	AUX
gra-2156	22	6	immediately	immediately	ADV
gra-2156	22	7	metabolized	metabolize	VERB
gra-2156	22	8	into	into	ADP
gra-2156	22	9	two	two	NUM
gra-2156	22	10	main	main	ADJ
gra-2156	22	11	active	active	ADJ
gra-2156	22	12	metabolites	metabolite	NOUN
gra-2156	22	13	m1	m1	NOUN
gra-2156	22	14	(	(	PUNCT
gra-2156	22	15	glya21	glya21	NOUN
gra-2156	22	16	)	)	PUNCT
gra-2156	22	17	and	and	CCONJ
gra-2156	22	18	m2	m2	PROPN
gra-2156	22	19	(	(	PUNCT
gra-2156	22	20	glya21	glya21	PROPN
gra-2156	22	21	,	,	PUNCT
gra-2156	22	22	des	des	X
gra-2156	22	23	thrb30	thrb30	PROPN
gra-2156	22	24	)	)	PUNCT
gra-2156	22	25	.	.	PUNCT
gra-2156	23	1	the	the	DET
gra-2156	23	2	m1	m1	PROPN
gra-2156	23	3	metabolite	metabolite	NOUN
gra-2156	23	4	accounts	account	VERB
gra-2156	23	5	for	for	ADP
gra-2156	23	6	approximately	approximately	ADV
gra-2156	23	7	90	90	NUM
gra-2156	23	8	%	%	NOUN
gra-2156	23	9	of	of	ADP
gra-2156	23	10	the	the	DET
gra-2156	23	11	daily	daily	ADJ
gra-2156	23	12	plasma	plasma	NOUN
gra-2156	23	13	insulin	insulin	NOUN
gra-2156	23	14	available	available	ADJ
gra-2156	23	15	.	.	PUNCT
gra-2156	24	1	this	this	PRON
gra-2156	24	2	protracted	protract	VERB
gra-2156	24	3	release	release	NOUN
gra-2156	24	4	of	of	ADP
gra-2156	24	5	glargine	glargine	NOUN
gra-2156	24	6	from	from	ADP
gra-2156	24	7	the	the	DET
gra-2156	24	8	subcutaneous	subcutaneous	ADJ
gra-2156	24	9	depot	depot	NOUN
gra-2156	24	10	translates	translate	VERB
gra-2156	24	11	into	into	ADP
gra-2156	24	12	longer	long	ADJ
gra-2156	24	13	bioactivity	bioactivity	NOUN
gra-2156	24	14	than	than	ADP
gra-2156	24	15	either	either	CCONJ
gra-2156	24	16	human	human	ADJ
gra-2156	24	17	nph	nph	PROPN
gra-2156	24	18	or	or	CCONJ
gra-2156	24	19	human	human	PROPN
gra-2156	24	20	ultra	ultra	ADJ
gra-2156	24	21	lente	lente	PROPN
gra-2156	24	22	insulin	insulin	NOUN
gra-2156	24	23	.	.	PUNCT
gra-2156	25	1	thus	thus	ADV
gra-2156	25	2	,	,	PUNCT
gra-2156	25	3	iglar	iglar	NOUN
gra-2156	25	4	can	can	AUX
gra-2156	25	5	be	be	AUX
gra-2156	25	6	administered	administer	VERB
gra-2156	25	7	once	once	ADV
gra-2156	25	8	daily	daily	ADV
gra-2156	25	9	,	,	PUNCT
gra-2156	25	10	unlike	unlike	ADP
gra-2156	25	11	the	the	DET
gra-2156	25	12	earlier	early	ADJ
gra-2156	25	13	'	'	PUNCT
gra-2156	25	14	intermediate'/'long	intermediate'/'long	NOUN
gra-2156	25	15	-	-	PUNCT
gra-2156	25	16	acting	act	VERB
gra-2156	25	17	'	'	PUNCT
gra-2156	25	18	insulin	insulin	NOUN
gra-2156	25	19	5preparations	5preparations	PROPN
gra-2156	25	20	.	.	PUNCT
gra-2156	26	1	iglar	iglar	ADV
gra-2156	26	2	once	once	ADV
gra-2156	26	3	daily	daily	ADV
gra-2156	26	4	has	have	AUX
gra-2156	26	5	been	be	AUX
gra-2156	26	6	shown	show	VERB
gra-2156	26	7	to	to	PART
gra-2156	26	8	achieve	achieve	VERB
gra-2156	26	9	superior	superior	ADJ
gra-2156	26	10	glycemic	glycemic	ADJ
gra-2156	26	11	control	control	NOUN
gra-2156	26	12	with	with	ADP
gra-2156	26	13	equivalent	equivalent	ADJ
gra-2156	26	14	or	or	CCONJ
gra-2156	26	15	lower	low	ADJ
gra-2156	26	16	rates	rate	NOUN
gra-2156	26	17	of	of	ADP
gra-2156	26	18	hypoglycemia	hypoglycemia	NOUN
gra-2156	26	19	compared	compare	VERB
gra-2156	26	20	with	with	ADP
gra-2156	26	21	nph	nph	PROPN
gra-2156	26	22	insulin	insulin	NOUN
gra-2156	26	23	in	in	ADP
gra-2156	26	24	patients	patient	NOUN
gra-2156	26	25	with	with	ADP
gra-2156	26	26	4t2	4t2	NOUN
gra-2156	26	27	dm	dm	NUM
gra-2156	26	28	.	.	PUNCT
gra-2156	27	1	clinical	clinical	ADJ
gra-2156	27	2	efficacy	efficacy	NOUN
gra-2156	27	3	of	of	ADP
gra-2156	27	4	iglar	iglar	ADJ
gra-2156	27	5	usage	usage	NOUN
gra-2156	27	6	of	of	ADP
gra-2156	27	7	nph	nph	NOUN
gra-2156	27	8	insulin	insulin	NOUN
gra-2156	27	9	is	be	AUX
gra-2156	27	10	most	most	ADV
gra-2156	27	11	often	often	ADV
gra-2156	27	12	limited	limit	VERB
gra-2156	27	13	due	due	ADP
gra-2156	27	14	to	to	ADP
gra-2156	27	15	the	the	DET
gra-2156	27	16	high	high	ADJ
gra-2156	27	17	risk	risk	NOUN
gra-2156	27	18	of	of	ADP
gra-2156	27	19	nocturnal	nocturnal	ADJ
gra-2156	27	20	hypoglycemia	hypoglycemia	NOUN
gra-2156	27	21	when	when	SCONJ
gra-2156	27	22	taken	take	VERB
gra-2156	27	23	at	at	ADP
gra-2156	27	24	bedtime	bedtime	NOUN
gra-2156	27	25	,	,	PUNCT
gra-2156	27	26	as	as	SCONJ
gra-2156	27	27	its	its	PRON
gra-2156	27	28	peak	peak	NOUN
gra-2156	27	29	of	of	ADP
gra-2156	27	30	the	the	DET
gra-2156	27	31	action	action	NOUN
gra-2156	27	32	occurs	occur	VERB
gra-2156	27	33	4–6	4–6	NUM
gra-2156	27	34	h	h	NOUN
gra-2156	27	35	post	post	NOUN
gra-2156	27	36	-	-	NOUN
gra-2156	27	37	injection	injection	NOUN
gra-2156	27	38	.	.	PUNCT
gra-2156	28	1	in	in	ADP
gra-2156	28	2	contrast	contrast	NOUN
gra-2156	28	3	,	,	PUNCT
gra-2156	28	4	the	the	DET
gra-2156	28	5	smoother	smooth	ADJ
gra-2156	28	6	activity	activity	NOUN
gra-2156	28	7	of	of	ADP
gra-2156	28	8	the	the	DET
gra-2156	28	9	long	long	ADV
gra-2156	28	10	-	-	PUNCT
gra-2156	28	11	acting	act	VERB
gra-2156	28	12	insulin	insulin	NOUN
gra-2156	28	13	analog	analog	NOUN
gra-2156	28	14	,	,	PUNCT
gra-2156	28	15	iglar	iglar	NOUN
gra-2156	28	16	,	,	PUNCT
gra-2156	28	17	allows	allow	VERB
gra-2156	28	18	more	more	ADJ
gra-2156	28	19	exibility	exibility	NOUN
gra-2156	28	20	in	in	ADP
gra-2156	28	21	dosing	dose	VERB
gra-2156	28	22	,	,	PUNCT
gra-2156	28	23	and	and	CCONJ
gra-2156	28	24	its	its	PRON
gra-2156	28	25	administration	administration	NOUN
gra-2156	28	26	is	be	AUX
gra-2156	28	27	less	less	ADV
gra-2156	28	28	strictly	strictly	ADV
gra-2156	28	29	bound	bind	VERB
gra-2156	28	30	to	to	ADP
gra-2156	28	31	the	the	DET
gra-2156	28	32	time	time	NOUN
gra-2156	28	33	of	of	ADP
gra-2156	28	34	injection	injection	NOUN
gra-2156	28	35	.	.	PUNCT
gra-2156	29	1	this	this	PRON
gra-2156	29	2	is	be	AUX
gra-2156	29	3	especially	especially	ADV
gra-2156	29	4	important	important	ADJ
gra-2156	29	5	for	for	ADP
gra-2156	29	6	certain	certain	ADJ
gra-2156	29	7	patient	patient	ADJ
gra-2156	29	8	populations	population	NOUN
gra-2156	29	9	where	where	SCONJ
gra-2156	29	10	hypoglycemia	hypoglycemia	NOUN
gra-2156	29	11	5poses	5pose	VERB
gra-2156	29	12	a	a	DET
gra-2156	29	13	greater	great	ADJ
gra-2156	29	14	risk	risk	NOUN
gra-2156	29	15	,	,	PUNCT
gra-2156	29	16	such	such	ADJ
gra-2156	29	17	as	as	ADP
gra-2156	29	18	the	the	DET
gra-2156	29	19	elderly	elderly	ADJ
gra-2156	29	20	.	.	PUNCT
gra-2156	30	1	hence	hence	ADV
gra-2156	30	2	,	,	PUNCT
gra-2156	30	3	iglar	iglar	NOUN
gra-2156	30	4	is	be	AUX
gra-2156	30	5	approved	approve	VERB
gra-2156	30	6	for	for	ADP
gra-2156	30	7	administration	administration	NOUN
gra-2156	30	8	at	at	ADP
gra-2156	30	9	any	any	DET
gra-2156	30	10	time	time	NOUN
gra-2156	30	11	of	of	ADP
gra-2156	30	12	day	day	NOUN
gra-2156	30	13	,	,	PUNCT
gra-2156	30	14	provided	provide	VERB
gra-2156	30	15	it	it	PRON
gra-2156	30	16	is	be	AUX
gra-2156	30	17	7at	7at	ADJ
gra-2156	30	18	the	the	DET
gra-2156	30	19	same	same	ADJ
gra-2156	30	20	time	time	NOUN
gra-2156	30	21	each	each	DET
gra-2156	30	22	day	day	NOUN
gra-2156	30	23	.	.	PUNCT
gra-2156	31	1	to	to	AUX
gra-2156	31	2	conrm	conrm	VERB
gra-2156	31	3	the	the	DET
gra-2156	31	4	non	non	NOUN
gra-2156	31	5	-	-	NOUN
gra-2156	31	6	occurrence	occurrence	NOUN
gra-2156	31	7	of	of	ADP
gra-2156	31	8	hypoglycemia	hypoglycemia	NOUN
gra-2156	31	9	post	post	ADJ
gra-2156	31	10	-	-	ADJ
gra-2156	31	11	iglar	iglar	ADJ
gra-2156	31	12	administration	administration	NOUN
gra-2156	31	13	,	,	PUNCT
gra-2156	31	14	porcellati	porcellati	PROPN
gra-2156	31	15	et	et	PROPN
gra-2156	31	16	al	al	PROPN
gra-2156	31	17	.	.	PROPN
gra-2156	31	18	,	,	PUNCT
gra-2156	31	19	7carried	7carrie	VERB
gra-2156	31	20	out	out	ADP
gra-2156	31	21	a	a	DET
gra-2156	31	22	study	study	NOUN
gra-2156	31	23	in	in	ADP
gra-2156	31	24	t2	t2	NOUN
gra-2156	31	25	dm	dm	PROPN
gra-2156	31	26	insulin	insulin	NOUN
gra-2156	31	27	-	-	PUNCT
gra-2156	31	28	treated	treat	VERB
gra-2156	31	29	patients	patient	NOUN
gra-2156	31	30	.	.	PUNCT
gra-2156	32	1	the	the	DET
gra-2156	32	2	study	study	NOUN
gra-2156	32	3	was	be	AUX
gra-2156	32	4	carried	carry	VERB
gra-2156	32	5	out	out	ADP
gra-2156	32	6	in	in	ADP
gra-2156	32	7	10	10	NUM
gra-2156	32	8	t2	t2	NOUN
gra-2156	32	9	dm	dm	NOUN
gra-2156	32	10	insulin	insulin	NOUN
gra-2156	32	11	-	-	PUNCT
gra-2156	32	12	treated	treat	VERB
gra-2156	32	13	persons	person	NOUN
gra-2156	32	14	were	be	AUX
gra-2156	32	15	studied	study	VERB
gra-2156	32	16	during	during	ADP
gra-2156	32	17	24	24	NUM
gra-2156	32	18	-	-	PUNCT
gra-2156	32	19	h	h	NOUN
gra-2156	32	20	euglycemic	euglycemic	ADJ
gra-2156	32	21	glucose	glucose	NOUN
gra-2156	32	22	clamp	clamp	NOUN
gra-2156	32	23	,	,	PUNCT
gra-2156	32	24	after	after	ADP
gra-2156	32	25	glargine	glargine	NOUN
gra-2156	32	26	injection	injection	NOUN
gra-2156	32	27	(	(	PUNCT
gra-2156	32	28	0.4	0.4	NUM
gra-2156	32	29	units	unit	NOUN
gra-2156	32	30	/	/	SYM
gra-2156	32	31	kg	kg	PROPN
gra-2156	32	32	s.c	s.c	PROPN
gra-2156	32	33	.	.	PROPN
gra-2156	32	34	)	)	PUNCT
gra-2156	32	35	,	,	PUNCT
gra-2156	32	36	either	either	CCONJ
gra-2156	32	37	in	in	ADP
gra-2156	32	38	the	the	DET
gra-2156	32	39	evening	evening	NOUN
gra-2156	32	40	(	(	PUNCT
gra-2156	32	41	2200	2200	NUM
gra-2156	32	42	h	h	NOUN
gra-2156	32	43	)	)	PUNCT
gra-2156	32	44	or	or	CCONJ
gra-2156	32	45	the	the	DET
gra-2156	32	46	insulin	insulin	NOUN
gra-2156	32	47	glargine	glargine	NOUN
gra-2156	32	48	in	in	ADP
gra-2156	32	49	type	type	NOUN
gra-2156	32	50	2	2	NUM
gra-2156	32	51	diabetes	diabetes	NOUN
gra-2156	32	52	original	original	ADJ
gra-2156	32	53	research	research	NOUN
gra-2156	32	54	paper	paper	PROPN
gra-2156	32	55	dr	dr	PROPN
gra-2156	32	56	.	.	PROPN
gra-2156	32	57	sanjay	sanjay	PROPN
gra-2156	32	58	mahajan	mahajan	PROPN
gra-2156	32	59	150	150	NUM
gra-2156	32	60	duplex	duplex	NOUN
gra-2156	32	61	apartments	apartment	NOUN
gra-2156	32	62	b-5	b-5	NUM
gra-2156	32	63	vasundhara	vasundhara	PROPN
gra-2156	32	64	enclave	enclave	PROPN
gra-2156	32	65	delhi-110096	delhi-110096	NOUN
gra-2156	32	66	medicine	medicine	NOUN
gra-2156	32	67	keywords	keyword	NOUN
gra-2156	32	68	:	:	PUNCT
gra-2156	32	69	volume-9	volume-9	NUM
gra-2156	32	70	,	,	PUNCT
gra-2156	32	71	issue-3	issue-3	NUM
gra-2156	32	72	,	,	PUNCT
gra-2156	32	73	march-2020	march-2020	ADJ
gra-2156	32	74	•	•	NOUN
gra-2156	32	75	print	print	NOUN
gra-2156	32	76	issn	issn	PROPN
gra-2156	32	77	no	no	NOUN
gra-2156	32	78	.	.	PROPN
gra-2156	33	1	2277	2277	NUM
gra-2156	33	2	8160	8160	NUM
gra-2156	33	3	•	•	NOUN
gra-2156	33	4	doi	doi	NOUN
gra-2156	33	5	:	:	PUNCT
gra-2156	33	6	10.36106	10.36106	NUM
gra-2156	33	7	/	/	SYM
gra-2156	33	8	gjra	gjra	PROPN
gra-2156	33	9	dr	dr	PROPN
gra-2156	33	10	.	.	PROPN
gra-2156	33	11	shweta	shweta	PROPN
gra-2156	33	12	bhanot	bhanot	PROPN
gra-2156	33	13	pandit	pandit	PROPN
gra-2156	33	14	*	*	PUNCT
gra-2156	33	15	pandit	pandit	PROPN
gra-2156	33	16	medical	medical	PROPN
gra-2156	33	17	near	near	ADP
gra-2156	33	18	mini	mini	ADJ
gra-2156	33	19	stadium	stadium	NOUN
gra-2156	33	20	padmnabhpur	padmnabhpur	NOUN
gra-2156	33	21	durg	durg	NOUN
gra-2156	33	22	(	(	PUNCT
gra-2156	33	23	cg	cg	NOUN
gra-2156	33	24	)	)	PUNCT
gra-2156	33	25	,	,	PUNCT
gra-2156	33	26	491001	491001	NUM
gra-2156	33	27	*	*	PUNCT
gra-2156	33	28	corresponding	correspond	VERB
gra-2156	33	29	author	author	NOUN
gra-2156	33	30	dr	dr	PROPN
gra-2156	33	31	jitendra	jitendra	PROPN
gra-2156	33	32	b	b	PROPN
gra-2156	33	33	patel	patel	PROPN
gra-2156	33	34	pruthvi	pruthvi	PROPN
gra-2156	33	35	med	med	PROPN
gra-2156	33	36	.	.	PUNCT
gra-2156	34	1	nursing	nursing	NOUN
gra-2156	34	2	home	home	PROPN
gra-2156	34	3	&	&	CCONJ
gra-2156	34	4	heart	heart	PROPN
gra-2156	34	5	centre	centre	PROPN
gra-2156	34	6	,	,	PUNCT
gra-2156	34	7	s.	s.	PROPN
gra-2156	34	8	p.	p.	PROPN
gra-2156	34	9	colony	colony	NOUN
gra-2156	34	10	,	,	PUNCT
gra-2156	34	11	naranpura	naranpura	ADJ
gra-2156	34	12	,	,	PUNCT
gra-2156	34	13	ahmedabad	ahmedabad	PROPN
gra-2156	34	14	dr	dr	PROPN
gra-2156	34	15	.	.	PROPN
gra-2156	34	16	sunil	sunil	PROPN
gra-2156	34	17	shirsikar	shirsikar	PROPN
gra-2156	34	18	dwara	dwara	PROPN
gra-2156	34	19	hospital	hospital	NOUN
gra-2156	34	20	,	,	PUNCT
gra-2156	34	21	101	101	NUM
gra-2156	34	22	,	,	PUNCT
gra-2156	34	23	rajanvan	rajanvan	PROPN
gra-2156	34	24	society	society	NOUN
gra-2156	34	25	near	near	ADP
gra-2156	34	26	centreal	centreal	PROPN
gra-2156	34	27	bank	bank	PROPN
gra-2156	34	28	,	,	PUNCT
gra-2156	34	29	n-9	n-9	X
gra-2156	34	30	hudco	hudco	PROPN
gra-2156	34	31	aurangabad	aurangabad	PROPN
gra-2156	34	32	,	,	PUNCT
gra-2156	34	33	431003	431003	NUM
gra-2156	34	34	dr	dr	PROPN
gra-2156	34	35	m.	m.	PROPN
gra-2156	34	36	g.	g.	PROPN
gra-2156	34	37	binu	binu	PROPN
gra-2156	34	38	gknm	gknm	VERB
gra-2156	34	39	,	,	PUNCT
gra-2156	34	40	avinashi	avinashi	ADJ
gra-2156	34	41	road	road	NOUN
gra-2156	34	42	,	,	PUNCT
gra-2156	34	43	coimbatore-641028	coimbatore-641028	ADJ
gra-2156	34	44	36	36	NUM
gra-2156	34	45	x	x	NOUN
gra-2156	34	46	gjra	gjra	PROPN
gra-2156	34	47	global	global	ADJ
gra-2156	34	48	journal	journal	PROPN
gra-2156	34	49	for	for	ADP
gra-2156	34	50	research	research	NOUN
gra-2156	34	51	analysis	analysis	NOUN
gra-2156	34	52	morning	morning	NOUN
gra-2156	34	53	(	(	PUNCT
gra-2156	34	54	1000	1000	NUM
gra-2156	34	55	h	h	NOUN
gra-2156	34	56	)	)	PUNCT
gra-2156	34	57	.	.	PUNCT
gra-2156	35	1	it	it	PRON
gra-2156	35	2	was	be	AUX
gra-2156	35	3	concluded	conclude	VERB
gra-2156	35	4	from	from	ADP
gra-2156	35	5	the	the	DET
gra-2156	35	6	study	study	NOUN
gra-2156	35	7	that	that	SCONJ
gra-2156	35	8	,	,	PUNCT
gra-2156	35	9	the	the	DET
gra-2156	35	10	pharmacodynamics	pharmacodynamic	NOUN
gra-2156	35	11	of	of	ADP
gra-2156	35	12	insulin	insulin	NOUN
gra-2156	35	13	glargine	glargine	NOUN
gra-2156	35	14	differs	differ	VERB
gra-2156	35	15	depending	depend	VERB
gra-2156	35	16	on	on	ADP
gra-2156	35	17	the	the	DET
gra-2156	35	18	time	time	NOUN
gra-2156	35	19	of	of	ADP
gra-2156	35	20	administration	administration	NOUN
gra-2156	35	21	.	.	PUNCT
gra-2156	36	1	with	with	ADP
gra-2156	36	2	morning	morning	NOUN
gra-2156	36	3	administration	administration	NOUN
gra-2156	36	4	insulin	insulin	NOUN
gra-2156	36	5	activity	activity	NOUN
gra-2156	36	6	is	be	AUX
gra-2156	36	7	greater	great	ADJ
gra-2156	36	8	in	in	ADP
gra-2156	36	9	the	the	DET
gra-2156	36	10	rst	rst	PROPN
gra-2156	36	11	0–12	0–12	PROPN
gra-2156	36	12	h	h	NOUN
gra-2156	36	13	,	,	PUNCT
gra-2156	36	14	while	while	SCONJ
gra-2156	36	15	with	with	ADP
gra-2156	36	16	evening	evening	NOUN
gra-2156	36	17	administration	administration	NOUN
gra-2156	36	18	the	the	DET
gra-2156	36	19	activity	activity	NOUN
gra-2156	36	20	is	be	AUX
gra-2156	36	21	greater	great	ADJ
gra-2156	36	22	in	in	ADP
gra-2156	36	23	the	the	DET
gra-2156	36	24	12–24	12–24	NUM
gra-2156	36	25	h	h	NOUN
gra-2156	36	26	period	period	NOUN
gra-2156	36	27	following	follow	VERB
gra-2156	36	28	dosing	dose	VERB
gra-2156	36	29	.	.	PUNCT
gra-2156	37	1	however	however	ADV
gra-2156	37	2	,	,	PUNCT
gra-2156	37	3	glargine	glargine	VERB
gra-2156	37	4	pharmacokinetics	pharmacokinetic	NOUN
gra-2156	37	5	and	and	CCONJ
gra-2156	37	6	plasma	plasma	NOUN
gra-2156	37	7	c	c	NOUN
gra-2156	37	8	-	-	PUNCT
gra-2156	37	9	peptide	peptide	NOUN
gra-2156	37	10	levels	level	NOUN
gra-2156	37	11	were	be	AUX
gra-2156	37	12	similar	similar	ADJ
gra-2156	37	13	,	,	PUNCT
gra-2156	37	14	when	when	SCONJ
gra-2156	37	15	analyzed	analyze	VERB
gra-2156	37	16	by	by	ADP
gra-2156	37	17	24	24	NUM
gra-2156	37	18	-	-	PUNCT
gra-2156	37	19	h	h	NOUN
gra-2156	37	20	clock	clock	NOUN
gra-2156	37	21	time	time	NOUN
gra-2156	37	22	independent	independent	ADJ
gra-2156	37	23	of	of	ADP
gra-2156	37	24	the	the	DET
gra-2156	37	25	time	time	NOUN
gra-2156	37	26	of	of	ADP
gra-2156	37	27	administration	administration	NOUN
gra-2156	37	28	.	.	PUNCT
gra-2156	38	1	thus	thus	ADV
gra-2156	38	2	,	,	PUNCT
gra-2156	38	3	insulin	insulin	NOUN
gra-2156	38	4	sensitivity	sensitivity	NOUN
gra-2156	38	5	in	in	ADP
gra-2156	38	6	t2	t2	NOUN
gra-2156	38	7	dm	dm	PROPN
gra-2156	38	8	is	be	AUX
gra-2156	38	9	affected	affect	VERB
gra-2156	38	10	by	by	ADP
gra-2156	38	11	circadian	circadian	ADJ
gra-2156	38	12	rhythm	rhythm	PROPN
gra-2156	38	13	7rather	7rather	NUM
gra-2156	38	14	than	than	ADP
gra-2156	38	15	glargine	glargine	NOUN
gra-2156	38	16	per	per	ADP
gra-2156	38	17	se	se	X
gra-2156	38	18	.	.	PUNCT
gra-2156	39	1	diabetic	diabetic	ADJ
gra-2156	39	2	kidney	kidney	NOUN
gra-2156	39	3	disease	disease	NOUN
gra-2156	39	4	is	be	AUX
gra-2156	39	5	one	one	NUM
gra-2156	39	6	of	of	ADP
gra-2156	39	7	the	the	DET
gra-2156	39	8	most	most	ADV
gra-2156	39	9	frequent	frequent	ADJ
gra-2156	39	10	microvascular	microvascular	NOUN
gra-2156	39	11	complications	complication	NOUN
gra-2156	39	12	related	relate	VERB
gra-2156	39	13	to	to	ADP
gra-2156	39	14	diabetes	diabetes	NOUN
gra-2156	39	15	mellitus	mellitus	NOUN
gra-2156	39	16	and	and	CCONJ
gra-2156	39	17	is	be	AUX
gra-2156	39	18	the	the	DET
gra-2156	39	19	leading	lead	VERB
gra-2156	39	20	cause	cause	NOUN
gra-2156	39	21	of	of	ADP
gra-2156	39	22	end	end	NOUN
gra-2156	39	23	-	-	PUNCT
gra-2156	39	24	stage	stage	NOUN
gra-2156	39	25	renal	renal	ADJ
gra-2156	39	26	disease	disease	NOUN
gra-2156	39	27	.	.	PUNCT
gra-2156	40	1	kidneys	kidney	NOUN
gra-2156	40	2	play	play	VERB
gra-2156	40	3	an	an	DET
gra-2156	40	4	important	important	ADJ
gra-2156	40	5	role	role	NOUN
gra-2156	40	6	in	in	ADP
gra-2156	40	7	the	the	DET
gra-2156	40	8	regulation	regulation	NOUN
gra-2156	40	9	of	of	ADP
gra-2156	40	10	glucose	glucose	NOUN
gra-2156	40	11	homeostasis	homeostasis	NOUN
gra-2156	40	12	,	,	PUNCT
gra-2156	40	13	because	because	SCONJ
gra-2156	40	14	they	they	PRON
gra-2156	40	15	release	release	VERB
gra-2156	40	16	a	a	DET
gra-2156	40	17	signicant	signicant	ADJ
gra-2156	40	18	amount	amount	NOUN
gra-2156	40	19	of	of	ADP
gra-2156	40	20	glucose	glucose	NOUN
gra-2156	40	21	in	in	ADP
gra-2156	40	22	the	the	DET
gra-2156	40	23	post	post	ADJ
gra-2156	40	24	-	-	ADJ
gra-2156	40	25	absorptive	absorptive	ADJ
gra-2156	40	26	state	state	NOUN
gra-2156	40	27	,	,	PUNCT
gra-2156	40	28	and	and	CCONJ
gra-2156	40	29	they	they	PRON
gra-2156	40	30	are	be	AUX
gra-2156	40	31	responsible	responsible	ADJ
gra-2156	40	32	for	for	ADP
gra-2156	40	33	approximately	approximately	ADV
gra-2156	40	34	one	one	NUM
gra-2156	40	35	-	-	PUNCT
gra-2156	40	36	third	third	NOUN
gra-2156	40	37	of	of	ADP
gra-2156	40	38	insulin	insulin	NOUN
gra-2156	40	39	degradation	degradation	NOUN
gra-2156	40	40	.	.	PUNCT
gra-2156	41	1	the	the	DET
gra-2156	41	2	progressive	progressive	ADJ
gra-2156	41	3	loss	loss	NOUN
gra-2156	41	4	of	of	ADP
gra-2156	41	5	kidney	kidney	NOUN
gra-2156	41	6	function	function	NOUN
gra-2156	41	7	,	,	PUNCT
gra-2156	41	8	and	and	CCONJ
gra-2156	41	9	its	its	PRON
gra-2156	41	10	consequent	consequent	ADJ
gra-2156	41	11	reduction	reduction	NOUN
gra-2156	41	12	in	in	ADP
gra-2156	41	13	parenchyma	parenchyma	NOUN
gra-2156	41	14	and	and	CCONJ
gra-2156	41	15	blood	blood	NOUN
gra-2156	41	16	ow	ow	PROPN
gra-2156	41	17	,	,	PUNCT
gra-2156	41	18	has	have	AUX
gra-2156	41	19	been	be	AUX
gra-2156	41	20	associated	associate	VERB
gra-2156	41	21	with	with	ADP
gra-2156	41	22	a	a	DET
gra-2156	41	23	lower	low	ADJ
gra-2156	41	24	capacity	capacity	NOUN
gra-2156	41	25	of	of	ADP
gra-2156	41	26	renal	renal	ADJ
gra-2156	41	27	glucose	glucose	NOUN
gra-2156	41	28	release	release	NOUN
gra-2156	41	29	,	,	PUNCT
gra-2156	41	30	drug	drug	NOUN
gra-2156	41	31	metabolism	metabolism	NOUN
gra-2156	41	32	,	,	PUNCT
gra-2156	41	33	and	and	CCONJ
gra-2156	41	34	excretion	excretion	NOUN
gra-2156	41	35	and	and	CCONJ
gra-2156	41	36	insulin	insulin	NOUN
gra-2156	41	37	extraction	extraction	NOUN
gra-2156	41	38	,	,	PUNCT
gra-2156	41	39	resulting	result	VERB
gra-2156	41	40	in	in	ADP
gra-2156	41	41	prolonged	prolonged	ADJ
gra-2156	41	42	half	half	ADJ
gra-2156	41	43	-	-	PUNCT
gra-2156	41	44	life	life	NOUN
gra-2156	41	45	of	of	ADP
gra-2156	41	46	some	some	DET
gra-2156	41	47	oral	oral	ADJ
gra-2156	41	48	antihyper	antihyper	NOUN
gra-2156	41	49	gl	gl	PROPN
gra-2156	41	50	ycemic	ycemic	ADJ
gra-2156	41	51	agents	agent	NOUN
gra-2156	41	52	and	and	CCONJ
gra-2156	41	53	insulin	insulin	NOUN
gra-2156	41	54	,	,	PUNCT
gra-2156	41	55	besides	besides	SCONJ
gra-2156	41	56	an	an	DET
gra-2156	41	57	impaired	impaired	ADJ
gra-2156	41	58	response	response	NOUN
gra-2156	41	59	to	to	ADP
gra-2156	41	60	hypoglycemia	hypoglycemia	NOUN
gra-2156	41	61	thus	thus	ADV
gra-2156	41	62	,	,	PUNCT
gra-2156	41	63	glycemic	glycemic	ADJ
gra-2156	41	64	control	control	NOUN
gra-2156	41	65	in	in	ADP
gra-2156	41	66	patients	patient	NOUN
gra-2156	41	67	with	with	ADP
gra-2156	41	68	chronic	chronic	ADJ
gra-2156	41	69	kidney	kidney	NOUN
gra-2156	41	70	disease	disease	NOUN
gra-2156	41	71	(	(	PUNCT
gra-2156	41	72	ckd	ckd	NOUN
gra-2156	41	73	)	)	PUNCT
gra-2156	41	74	is	be	AUX
gra-2156	41	75	particularly	particularly	ADV
gra-2156	41	76	hard	hard	ADJ
gra-2156	41	77	to	to	PART
gra-2156	41	78	achieve	achieve	VERB
gra-2156	41	79	because	because	SCONJ
gra-2156	41	80	of	of	ADP
gra-2156	41	81	a	a	DET
gra-2156	41	82	slower	slow	ADJ
gra-2156	41	83	insulin	insulin	NOUN
gra-2156	41	84	degradation	degradation	NOUN
gra-2156	41	85	by	by	ADP
gra-2156	41	86	the	the	DET
gra-2156	41	87	kidney	kidney	NOUN
gra-2156	41	88	.	.	PUNCT
gra-2156	42	1	it	it	PRON
gra-2156	42	2	might	might	AUX
gra-2156	42	3	modify	modify	VERB
gra-2156	42	4	the	the	DET
gra-2156	42	5	long	long	ADV
gra-2156	42	6	-	-	PUNCT
gra-2156	42	7	acting	act	VERB
gra-2156	42	8	insulin	insulin	NOUN
gra-2156	42	9	analogue	analogue	NOUN
gra-2156	42	10	pharmacokinetics	pharmacokinetic	NOUN
gra-2156	42	11	,	,	PUNCT
gra-2156	42	12	8increasing	8increase	VERB
gra-2156	42	13	its	its	PRON
gra-2156	42	14	time	time	NOUN
gra-2156	42	15	of	of	ADP
gra-2156	42	16	action	action	NOUN
gra-2156	42	17	and	and	CCONJ
gra-2156	42	18	the	the	DET
gra-2156	42	19	risk	risk	NOUN
gra-2156	42	20	of	of	ADP
gra-2156	42	21	hypoglycemia	hypoglycemia	NOUN
gra-2156	42	22	.	.	PUNCT
gra-2156	43	1	betonico	betonico	NOUN
gra-2156	43	2	et	et	PROPN
gra-2156	43	3	al	al	PROPN
gra-2156	43	4	.	.	PROPN
gra-2156	43	5	examined	examine	VERB
gra-2156	43	6	the	the	DET
gra-2156	43	7	efcacy	efcacy	NOUN
gra-2156	43	8	and	and	CCONJ
gra-2156	43	9	safety	safety	NOUN
gra-2156	43	10	prole	prole	PROPN
gra-2156	43	11	of	of	ADP
gra-2156	43	12	long	long	ADV
gra-2156	43	13	-	-	PUNCT
gra-2156	43	14	acting	act	VERB
gra-2156	43	15	basal	basal	ADJ
gra-2156	43	16	analogues	analogue	NOUN
gra-2156	43	17	in	in	ADP
gra-2156	43	18	patients	patient	NOUN
gra-2156	43	19	with	with	ADP
gra-2156	43	20	signicant	signicant	ADJ
gra-2156	43	21	loss	loss	NOUN
gra-2156	43	22	of	of	ADP
gra-2156	43	23	renal	renal	ADJ
gra-2156	43	24	function	function	NOUN
gra-2156	43	25	.	.	PUNCT
gra-2156	44	1	a	a	DET
gra-2156	44	2	comparison	comparison	NOUN
gra-2156	44	3	of	of	ADP
gra-2156	44	4	the	the	DET
gra-2156	44	5	glycemic	glycemic	ADJ
gra-2156	44	6	response	response	NOUN
gra-2156	44	7	to	to	ADP
gra-2156	44	8	treatment	treatment	NOUN
gra-2156	44	9	with	with	ADP
gra-2156	44	10	iglar	iglar	NOUN
gra-2156	44	11	u100	u100	PROPN
gra-2156	44	12	or	or	CCONJ
gra-2156	44	13	nph	nph	PROPN
gra-2156	44	14	insulin	insulin	NOUN
gra-2156	44	15	in	in	ADP
gra-2156	44	16	patients	patient	NOUN
gra-2156	44	17	with	with	ADP
gra-2156	44	18	type	type	NOUN
gra-2156	44	19	2	2	NUM
gra-2156	44	20	diabetes	diabetes	NOUN
gra-2156	44	21	mellitus	mellitus	NOUN
gra-2156	44	22	(	(	PUNCT
gra-2156	44	23	t2	t2	NOUN
gra-2156	44	24	dm	dm	PROPN
gra-2156	44	25	)	)	PUNCT
gra-2156	44	26	and	and	CCONJ
gra-2156	44	27	ckd	ckd	PROPN
gra-2156	44	28	stages	stage	NOUN
gra-2156	44	29	3	3	NUM
gra-2156	44	30	and	and	CCONJ
gra-2156	44	31	4	4	NUM
gra-2156	44	32	was	be	AUX
gra-2156	44	33	done	do	VERB
gra-2156	44	34	in	in	ADP
gra-2156	44	35	34	34	NUM
gra-2156	44	36	patients	patient	NOUN
gra-2156	44	37	.	.	PUNCT
gra-2156	45	1	after	after	ADP
gra-2156	45	2	24	24	NUM
gra-2156	45	3	weeks	week	NOUN
gra-2156	45	4	,	,	PUNCT
gra-2156	45	5	mean	mean	VERB
gra-2156	45	6	hba1c	hba1c	PROPN
gra-2156	45	7	was	be	AUX
gra-2156	45	8	found	find	VERB
gra-2156	45	9	to	to	PART
gra-2156	45	10	decrease	decrease	VERB
gra-2156	45	11	on	on	ADP
gra-2156	45	12	iglar	iglar	ADJ
gra-2156	45	13	u100	u100	PROPN
gra-2156	45	14	treatment	treatment	NOUN
gra-2156	45	15	(	(	PUNCT
gra-2156	45	16	−0.91	−0.91	NOUN
gra-2156	45	17	%	%	NOUN
gra-2156	45	18	;	;	PUNCT
gra-2156	45	19	p	p	X
gra-2156	45	20	<	<	X
gra-2156	45	21	0.001	0.001	NUM
gra-2156	45	22	)	)	PUNCT
gra-2156	45	23	,	,	PUNCT
gra-2156	45	24	however	however	ADV
gra-2156	45	25	,	,	PUNCT
gra-2156	45	26	this	this	PRON
gra-2156	45	27	benet	benet	ADV
gra-2156	45	28	was	be	AUX
gra-2156	45	29	not	not	PART
gra-2156	45	30	observed	observe	VERB
gra-2156	45	31	for	for	ADP
gra-2156	45	32	nph	nph	X
gra-2156	45	33	(	(	PUNCT
gra-2156	45	34	0.23	0.23	NUM
gra-2156	45	35	%	%	NOUN
gra-2156	45	36	;	;	PUNCT
gra-2156	45	37	p	p	X
gra-2156	45	38	¼	¼	NOUN
gra-2156	45	39	0.93	0.93	NUM
gra-2156	45	40	)	)	PUNCT
gra-2156	45	41	.	.	PUNCT
gra-2156	46	1	moreover	moreover	ADV
gra-2156	46	2	,	,	PUNCT
gra-2156	46	3	the	the	DET
gra-2156	46	4	incidence	incidence	NOUN
gra-2156	46	5	of	of	ADP
gra-2156	46	6	nocturnal	nocturnal	ADJ
gra-2156	46	7	hypoglycemia	hypoglycemia	NOUN
gra-2156	46	8	was	be	AUX
gra-2156	46	9	found	find	VERB
gra-2156	46	10	to	to	PART
gra-2156	46	11	be	be	AUX
gra-2156	46	12	3	3	NUM
gra-2156	46	13	times	time	NOUN
gra-2156	46	14	lower	low	ADJ
gra-2156	46	15	with	with	ADP
gra-2156	46	16	iglar	iglar	NOUN
gra-2156	46	17	than	than	ADP
gra-2156	46	18	with	with	ADP
gra-2156	46	19	nph	nph	PROPN
gra-2156	46	20	insulin	insulin	NOUN
gra-2156	46	21	(	(	PUNCT
gra-2156	46	22	p	p	X
gra-2156	46	23	¼	¼	NOUN
gra-2156	46	24	0.047	0.047	NUM
gra-2156	46	25	)	)	PUNCT
gra-2156	46	26	.	.	PUNCT
gra-2156	47	1	thus	thus	ADV
gra-2156	47	2	indicating	indicate	VERB
gra-2156	47	3	the	the	DET
gra-2156	47	4	potential	potential	NOUN
gra-2156	47	5	of	of	ADP
gra-2156	47	6	iglar	iglar	ADJ
gra-2156	47	7	u100	u100	PROPN
gra-2156	47	8	in	in	ADP
gra-2156	47	9	patients	patient	NOUN
gra-2156	47	10	8with	8with	NUM
gra-2156	47	11	t2	t2	NOUN
gra-2156	47	12	dm	dm	PROPN
gra-2156	47	13	and	and	CCONJ
gra-2156	47	14	ckd	ckd	PROPN
gra-2156	47	15	stages	stage	NOUN
gra-2156	47	16	3	3	NUM
gra-2156	47	17	and	and	CCONJ
gra-2156	47	18	4	4	NUM
gra-2156	47	19	without	without	ADP
gra-2156	47	20	resulting	result	VERB
gra-2156	47	21	in	in	ADP
gra-2156	47	22	signicant	signicant	ADJ
gra-2156	47	23	hypoglycemia	hypoglycemia	NOUN
gra-2156	47	24	.	.	PUNCT
gra-2156	48	1	traditionally	traditionally	ADV
gra-2156	48	2	,	,	PUNCT
gra-2156	48	3	basal	basal	ADJ
gra-2156	48	4	insulin	insulin	NOUN
gra-2156	48	5	is	be	AUX
gra-2156	48	6	initiated	initiate	VERB
gra-2156	48	7	on	on	ADP
gra-2156	48	8	the	the	DET
gra-2156	48	9	failure	failure	NOUN
gra-2156	48	10	of	of	ADP
gra-2156	48	11	a	a	DET
gra-2156	48	12	standard	standard	ADJ
gra-2156	48	13	therapeutic	therapeutic	ADJ
gra-2156	48	14	oral	oral	ADJ
gra-2156	48	15	anti	anti	ADJ
gra-2156	48	16	-	-	ADJ
gra-2156	48	17	diabetic	diabetic	ADJ
gra-2156	48	18	regimen	regiman	NOUN
gra-2156	48	19	and	and	CCONJ
gra-2156	48	20	is	be	AUX
gra-2156	48	21	given	give	VERB
gra-2156	48	22	as	as	ADP
gra-2156	48	23	an	an	DET
gra-2156	48	24	additional	additional	ADJ
gra-2156	48	25	hypoglycemic	hypoglycemic	ADJ
gra-2156	48	26	agent	agent	NOUN
gra-2156	48	27	along	along	ADP
gra-2156	48	28	with	with	ADP
gra-2156	48	29	oral	oral	ADJ
gra-2156	48	30	antidiabetics	antidiabetic	NOUN
gra-2156	48	31	.	.	PUNCT
gra-2156	49	1	eliaschewitz	eliaschewitz	PROPN
gra-2156	49	2	et	et	PROPN
gra-2156	49	3	al	al	PROPN
gra-2156	49	4	.	.	PROPN
gra-2156	49	5	,	,	PUNCT
gra-2156	49	6	compared	compare	VERB
gra-2156	49	7	the	the	DET
gra-2156	49	8	efcacy	efcacy	NOUN
gra-2156	49	9	and	and	CCONJ
gra-2156	49	10	safety	safety	NOUN
gra-2156	49	11	of	of	ADP
gra-2156	49	12	iglar	iglar	NOUN
gra-2156	49	13	and	and	CCONJ
gra-2156	49	14	nph	nph	NOUN
gra-2156	49	15	insulin	insulin	NOUN
gra-2156	49	16	,	,	PUNCT
gra-2156	49	17	both	both	CCONJ
gra-2156	49	18	in	in	ADP
gra-2156	49	19	combination	combination	NOUN
gra-2156	49	20	with	with	ADP
gra-2156	49	21	a	a	DET
gra-2156	49	22	once	once	ADV
gra-2156	49	23	-	-	PUNCT
gra-2156	49	24	daily	daily	ADJ
gra-2156	49	25	xed	xe	VERB
gra-2156	49	26	-	-	PUNCT
gra-2156	49	27	dose	dose	NOUN
gra-2156	49	28	of	of	ADP
gra-2156	49	29	glimepiride	glimepiride	NOUN
gra-2156	49	30	,	,	PUNCT
gra-2156	49	31	in	in	ADP
gra-2156	49	32	terms	term	NOUN
gra-2156	49	33	of	of	ADP
gra-2156	49	34	glycemic	glycemic	ADJ
gra-2156	49	35	control	control	NOUN
gra-2156	49	36	and	and	CCONJ
gra-2156	49	37	incidence	incidence	NOUN
gra-2156	49	38	of	of	ADP
gra-2156	49	39	hypoglycemia	hypoglycemia	NOUN
gra-2156	49	40	in	in	ADP
gra-2156	49	41	an	an	DET
gra-2156	49	42	open	open	ADJ
gra-2156	49	43	-	-	PUNCT
gra-2156	49	44	label	label	NOUN
gra-2156	49	45	,	,	PUNCT
gra-2156	49	46	244week	244week	PROPN
gra-2156	49	47	randomized	randomize	VERB
gra-2156	49	48	trial	trial	NOUN
gra-2156	49	49	in	in	ADP
gra-2156	49	50	ten	ten	NUM
gra-2156	49	51	latin	latin	ADJ
gra-2156	49	52	american	american	ADJ
gra-2156	49	53	countries	country	NOUN
gra-2156	49	54	.	.	PUNCT
gra-2156	50	1	it	it	PRON
gra-2156	50	2	was	be	AUX
gra-2156	50	3	found	find	VERB
gra-2156	50	4	that	that	SCONJ
gra-2156	50	5	iglar	iglar	NOUN
gra-2156	50	6	and	and	CCONJ
gra-2156	50	7	nph	nph	PROPN
gra-2156	50	8	insulin	insulin	NOUN
gra-2156	50	9	achieved	achieve	VERB
gra-2156	50	10	similar	similar	ADJ
gra-2156	50	11	hba1c	hba1c	PROPN
gra-2156	50	12	reductions	reduction	NOUN
gra-2156	50	13	(	(	PUNCT
gra-2156	50	14	adjusted	adjust	VERB
gra-2156	50	15	mean	mean	ADJ
gra-2156	50	16	difference	difference	NOUN
gra-2156	50	17	20.047	20.047	NUM
gra-2156	50	18	;	;	PUNCT
gra-2156	50	19	90	90	NUM
gra-2156	50	20	%	%	NOUN
gra-2156	50	21	ci	ci	PROPN
gra-2156	50	22	20.232	20.232	NUM
gra-2156	50	23	,	,	PUNCT
gra-2156	50	24	0.138	0.138	NUM
gra-2156	50	25	;	;	PUNCT
gra-2156	50	26	per	per	ADP
gra-2156	50	27	-	-	PUNCT
gra-2156	50	28	protocol	protocol	NOUN
gra-2156	50	29	analysis	analysis	NOUN
gra-2156	50	30	)	)	PUNCT
gra-2156	50	31	.	.	PUNCT
gra-2156	51	1	however	however	ADV
gra-2156	51	2	,	,	PUNCT
gra-2156	51	3	conrmed	conrme	VERB
gra-2156	51	4	nocturnal	nocturnal	ADJ
gra-2156	51	5	hypoglycemia	hypoglycemia	NOUN
gra-2156	51	6	was	be	AUX
gra-2156	51	7	signicantly	signicantly	ADV
gra-2156	51	8	lower	low	ADJ
gra-2156	51	9	with	with	ADP
gra-2156	51	10	iglar	iglar	NOUN
gra-2156	51	11	vs.	vs.	ADP
gra-2156	51	12	nph	nph	PROPN
gra-2156	51	13	insulin	insulin	NOUN
gra-2156	51	14	(	(	PUNCT
gra-2156	51	15	16.9	16.9	NUM
gra-2156	51	16	vs.	vs.	ADP
gra-2156	51	17	30.0	30.0	NUM
gra-2156	51	18	%	%	NOUN
gra-2156	51	19	;	;	PUNCT
gra-2156	51	20	p<!0.01	p<!0.01	X
gra-2156	51	21	;	;	PUNCT
gra-2156	51	22	safety	safety	NOUN
gra-2156	51	23	analysis	analysis	NOUN
gra-2156	51	24	)	)	PUNCT
gra-2156	51	25	.	.	PUNCT
gra-2156	52	1	patients	patient	NOUN
gra-2156	52	2	receiving	receive	VERB
gra-2156	52	3	iglar	iglar	NOUN
gra-2156	52	4	were	be	AUX
gra-2156	52	5	signicantly	signicantly	ADV
gra-2156	52	6	more	more	ADV
gra-2156	52	7	likely	likely	ADJ
gra-2156	52	8	to	to	PART
gra-2156	52	9	achieve	achieve	VERB
gra-2156	52	10	hba1c	hba1c	PROPN
gra-2156	52	11	levels	level	NOUN
gra-2156	52	12	<	<	X
gra-2156	52	13	7.0	7.0	NUM
gra-2156	52	14	%	%	NOUN
gra-2156	52	15	without	without	ADP
gra-2156	52	16	hypoglycemia	hypoglycemia	NOUN
gra-2156	52	17	(	(	PUNCT
gra-2156	52	18	27	27	NUM
gra-2156	52	19	vs.	vs.	ADP
gra-2156	52	20	17	17	NUM
gra-2156	52	21	%	%	NOUN
gra-2156	52	22	;	;	PUNCT
gra-2156	52	23	p	p	PROPN
gra-2156	52	24	=	=	NOUN
gra-2156	52	25	0.014	0.014	NUM
gra-2156	52	26	;	;	PUNCT
gra-2156	52	27	per	per	ADP
gra-2156	52	28	-	-	PUNCT
gra-2156	52	29	protocol	protocol	NOUN
gra-2156	52	30	analysis	analysis	NOUN
gra-2156	52	31	)	)	PUNCT
gra-2156	52	32	.	.	PUNCT
gra-2156	53	1	there	there	PRON
gra-2156	53	2	was	be	VERB
gra-2156	53	3	a	a	DET
gra-2156	53	4	more	more	ADV
gra-2156	53	5	pronounced	pronounced	ADJ
gra-2156	53	6	treatment	treatment	NOUN
gra-2156	53	7	satisfaction	satisfaction	NOUN
gra-2156	53	8	improvement	improvement	NOUN
gra-2156	53	9	with	with	ADP
gra-2156	53	10	insulin	insulin	NOUN
gra-2156	53	11	glargine	glargine	NOUN
gra-2156	53	12	vs.	vs.	ADP
gra-2156	53	13	nph	nph	PROPN
gra-2156	53	14	insulin	insulin	NOUN
gra-2156	53	15	(	(	PUNCT
gra-2156	53	16	p	p	X
gra-2156	53	17	<	<	X
gra-2156	53	18	0.02	0.02	NUM
gra-2156	53	19	;	;	PUNCT
gra-2156	53	20	full	full	ADJ
gra-2156	53	21	analysis	analysis	NOUN
gra-2156	53	22	)	)	PUNCT
gra-2156	53	23	.	.	PUNCT
gra-2156	54	1	thus	thus	ADV
gra-2156	54	2	,	,	PUNCT
gra-2156	54	3	once	once	ADV
gra-2156	54	4	-	-	PUNCT
gra-2156	54	5	daily	daily	ADJ
gra-2156	54	6	iglar	iglar	NOUN
gra-2156	54	7	plus	plus	CCONJ
gra-2156	54	8	glimepiride	glimepiride	NOUN
gra-2156	54	9	is	be	AUX
gra-2156	54	10	effective	effective	ADJ
gra-2156	54	11	in	in	ADP
gra-2156	54	12	improving	improve	VERB
gra-2156	54	13	metabolic	metabolic	NOUN
gra-2156	54	14	control	control	NOUN
gra-2156	54	15	with	with	ADP
gra-2156	54	16	a	a	DET
gra-2156	54	17	reduced	reduced	ADJ
gra-2156	54	18	incidence	incidence	NOUN
gra-2156	54	19	of	of	ADP
gra-2156	54	20	nocturnal	nocturnal	ADJ
gra-2156	54	21	hypoglycemia	hypoglycemia	NOUN
gra-2156	54	22	4compared	4compared	NUM
gra-2156	54	23	with	with	ADP
gra-2156	54	24	nph	nph	NOUN
gra-2156	54	25	insulin	insulin	NOUN
gra-2156	54	26	.	.	PUNCT
gra-2156	55	1	another	another	DET
gra-2156	55	2	major	major	ADJ
gra-2156	55	3	complication	complication	NOUN
gra-2156	55	4	of	of	ADP
gra-2156	55	5	diabetes	diabetes	NOUN
gra-2156	55	6	is	be	AUX
gra-2156	55	7	the	the	DET
gra-2156	55	8	occurrence	occurrence	NOUN
gra-2156	55	9	of	of	ADP
gra-2156	55	10	cardiovascular	cardiovascular	ADJ
gra-2156	55	11	complications	complication	NOUN
gra-2156	55	12	.	.	PUNCT
gra-2156	56	1	cardiovascular	cardiovascular	ADJ
gra-2156	56	2	disease	disease	NOUN
gra-2156	56	3	is	be	AUX
gra-2156	56	4	the	the	DET
gra-2156	56	5	leading	lead	VERB
gra-2156	56	6	cause	cause	NOUN
gra-2156	56	7	of	of	ADP
gra-2156	56	8	mortality	mortality	NOUN
gra-2156	56	9	in	in	ADP
gra-2156	56	10	t2	t2	PROPN
gra-2156	56	11	dm	dm	PROPN
gra-2156	56	12	.	.	PUNCT
gra-2156	56	13	hyperinsulinemia	hyperinsulinemia	NOUN
gra-2156	56	14	has	have	AUX
gra-2156	56	15	been	be	AUX
gra-2156	56	16	reported	report	VERB
gra-2156	56	17	to	to	PART
gra-2156	56	18	be	be	AUX
gra-2156	56	19	associated	associate	VERB
gra-2156	56	20	with	with	ADP
gra-2156	56	21	increased	increase	VERB
gra-2156	56	22	cardiovascular	cardiovascular	ADJ
gra-2156	56	23	risk	risk	NOUN
gra-2156	56	24	.	.	PUNCT
gra-2156	57	1	progression	progression	NOUN
gra-2156	57	2	of	of	ADP
gra-2156	57	3	atherosclerosis	atherosclerosis	NOUN
gra-2156	57	4	has	have	AUX
gra-2156	57	5	been	be	AUX
gra-2156	57	6	proposed	propose	VERB
gra-2156	57	7	to	to	PART
gra-2156	57	8	be	be	AUX
gra-2156	57	9	associated	associate	VERB
gra-2156	57	10	with	with	ADP
gra-2156	57	11	hyperinsulinemia	hyperinsulinemia	NOUN
gra-2156	57	12	.	.	PUNCT
gra-2156	58	1	however	however	ADV
gra-2156	58	2	,	,	PUNCT
gra-2156	58	3	the	the	DET
gra-2156	58	4	effects	effect	NOUN
gra-2156	58	5	of	of	ADP
gra-2156	58	6	exogenous	exogenous	ADJ
gra-2156	58	7	insulin	insulin	NOUN
gra-2156	58	8	on	on	ADP
gra-2156	58	9	cardiovascular	cardiovascular	ADJ
gra-2156	58	10	disease	disease	NOUN
gra-2156	58	11	progression	progression	NOUN
gra-2156	58	12	has	have	AUX
gra-2156	58	13	not	not	PART
gra-2156	58	14	been	be	AUX
gra-2156	58	15	well	well	ADV
gra-2156	58	16	studied	study	VERB
gra-2156	58	17	.	.	PUNCT
gra-2156	59	1	the	the	DET
gra-2156	59	2	origin	origin	NOUN
gra-2156	59	3	trial	trial	NOUN
gra-2156	59	4	is	be	AUX
gra-2156	59	5	the	the	DET
gra-2156	59	6	only	only	ADJ
gra-2156	59	7	study	study	NOUN
gra-2156	59	8	to	to	ADP
gra-2156	59	9	date	date	NOUN
gra-2156	59	10	dedicated	dedicate	VERB
gra-2156	59	11	to	to	PART
gra-2156	59	12	investigate	investigate	VERB
gra-2156	59	13	the	the	DET
gra-2156	59	14	effects	effect	NOUN
gra-2156	59	15	of	of	ADP
gra-2156	59	16	iglar	iglar	NOUN
gra-2156	59	17	on	on	ADP
gra-2156	59	18	cardiovascular	cardiovascular	ADJ
gra-2156	59	19	outcomes	outcome	NOUN
gra-2156	59	20	.	.	PUNCT
gra-2156	60	1	origin	origin	PROPN
gra-2156	60	2	enrolled	enrol	VERB
gra-2156	60	3	12,537	12,537	NUM
gra-2156	60	4	patients	patient	NOUN
gra-2156	60	5	with	with	ADP
gra-2156	60	6	a	a	DET
gra-2156	60	7	mean	mean	ADJ
gra-2156	60	8	age	age	NOUN
gra-2156	60	9	of	of	ADP
gra-2156	60	10	63.5	63.5	NUM
gra-2156	60	11	years	year	NOUN
gra-2156	60	12	,	,	PUNCT
gra-2156	60	13	cardiovascular	cardiovascular	ADJ
gra-2156	60	14	risk	risk	NOUN
gra-2156	60	15	factors	factor	NOUN
gra-2156	60	16	and	and	CCONJ
gra-2156	60	17	impaired	impaired	ADJ
gra-2156	60	18	fasting	fasting	NOUN
gra-2156	60	19	glucose	glucose	NOUN
gra-2156	60	20	,	,	PUNCT
gra-2156	60	21	impaired	impaired	ADJ
gra-2156	60	22	glucose	glucose	NOUN
gra-2156	60	23	tolerance	tolerance	NOUN
gra-2156	60	24	or	or	CCONJ
gra-2156	60	25	type	type	NOUN
gra-2156	60	26	2	2	NUM
gra-2156	60	27	diabetes	diabetes	NOUN
gra-2156	60	28	.	.	PUNCT
gra-2156	61	1	patients	patient	NOUN
gra-2156	61	2	were	be	AUX
gra-2156	61	3	randomized	randomize	VERB
gra-2156	61	4	to	to	PART
gra-2156	61	5	receive	receive	VERB
gra-2156	61	6	iglar	iglar	NOUN
gra-2156	61	7	with	with	ADP
gra-2156	61	8	a	a	DET
gra-2156	61	9	target	target	NOUN
gra-2156	61	10	fasting	fast	VERB
gra-2156	61	11	glucose	glucose	NOUN
gra-2156	61	12	of	of	ADP
gra-2156	61	13	less	less	ADJ
gra-2156	61	14	than	than	ADP
gra-2156	61	15	95	95	NUM
gra-2156	61	16	mg	mg	PROPN
gra-2156	61	17	/	/	SYM
gra-2156	61	18	dl	dl	PROPN
gra-2156	61	19	or	or	CCONJ
gra-2156	61	20	standard	standard	ADJ
gra-2156	61	21	glycemic	glycemic	ADJ
gra-2156	61	22	care	care	NOUN
gra-2156	61	23	.	.	PUNCT
gra-2156	62	1	at	at	ADP
gra-2156	62	2	the	the	DET
gra-2156	62	3	end	end	NOUN
gra-2156	62	4	of	of	ADP
gra-2156	62	5	the	the	DET
gra-2156	62	6	study	study	NOUN
gra-2156	62	7	,	,	PUNCT
gra-2156	62	8	83.6	83.6	NUM
gra-2156	62	9	%	%	NOUN
gra-2156	62	10	of	of	ADP
gra-2156	62	11	patients	patient	NOUN
gra-2156	62	12	in	in	ADP
gra-2156	62	13	the	the	DET
gra-2156	62	14	glargine	glargine	NOUN
gra-2156	62	15	group	group	NOUN
gra-2156	62	16	were	be	AUX
gra-2156	62	17	on	on	ADP
gra-2156	62	18	insulin	insulin	NOUN
gra-2156	62	19	compared	compare	VERB
gra-2156	62	20	with	with	ADP
gra-2156	62	21	11.4	11.4	NUM
gra-2156	62	22	%	%	NOUN
gra-2156	62	23	in	in	ADP
gra-2156	62	24	the	the	DET
gra-2156	62	25	standard	standard	PROPN
gra-2156	62	26	care	care	NOUN
gra-2156	62	27	group	group	NOUN
gra-2156	62	28	.	.	PUNCT
gra-2156	63	1	the	the	DET
gra-2156	63	2	hba1c	hba1c	PROPN
gra-2156	63	3	in	in	ADP
gra-2156	63	4	year	year	NOUN
gra-2156	63	5	7	7	NUM
gra-2156	63	6	was	be	AUX
gra-2156	63	7	6.2	6.2	NUM
gra-2156	63	8	%	%	NOUN
gra-2156	63	9	in	in	ADP
gra-2156	63	10	the	the	DET
gra-2156	63	11	glargine	glargine	NOUN
gra-2156	63	12	group	group	NOUN
gra-2156	63	13	and	and	CCONJ
gra-2156	63	14	6.5	6.5	NUM
gra-2156	63	15	%	%	NOUN
gra-2156	63	16	in	in	ADP
gra-2156	63	17	the	the	DET
gra-2156	63	18	standard	standard	PROPN
gra-2156	63	19	care	care	NOUN
gra-2156	63	20	group	group	NOUN
gra-2156	63	21	.	.	PUNCT
gra-2156	64	1	however	however	ADV
gra-2156	64	2	,	,	PUNCT
gra-2156	64	3	the	the	DET
gra-2156	64	4	study	study	NOUN
gra-2156	64	5	found	find	VERB
gra-2156	64	6	no	no	DET
gra-2156	64	7	difference	difference	NOUN
gra-2156	64	8	in	in	ADP
gra-2156	64	9	co	co	ADJ
gra-2156	64	10	-	-	ADJ
gra-2156	64	11	primary	primary	ADJ
gra-2156	64	12	outcomes	outcome	NOUN
gra-2156	64	13	of	of	ADP
gra-2156	64	14	nonfatal	nonfatal	PROPN
gra-2156	64	15	mi	mi	PROPN
gra-2156	64	16	,	,	PUNCT
gra-2156	64	17	nonfatal	nonfatal	ADJ
gra-2156	64	18	stroke	stroke	NOUN
gra-2156	64	19	or	or	CCONJ
gra-2156	64	20	death	death	NOUN
gra-2156	64	21	from	from	ADP
gra-2156	64	22	cardiovascular	cardiovascular	ADJ
gra-2156	64	23	9disease	9disease	NUM
gra-2156	64	24	after	after	ADP
gra-2156	64	25	a	a	DET
gra-2156	64	26	median	median	ADJ
gra-2156	64	27	follow	follow	NOUN
gra-2156	64	28	-	-	PUNCT
gra-2156	64	29	up	up	NOUN
gra-2156	64	30	of	of	ADP
gra-2156	64	31	6.2	6.2	NUM
gra-2156	64	32	years	year	NOUN
gra-2156	64	33	.	.	PUNCT
gra-2156	65	1	further	far	ADV
gra-2156	65	2	,	,	PUNCT
gra-2156	65	3	a	a	DET
gra-2156	65	4	metaanalysis	metaanalysis	NOUN
gra-2156	65	5	of	of	ADP
gra-2156	65	6	outcomes	outcome	NOUN
gra-2156	65	7	from	from	ADP
gra-2156	65	8	accord	accord	NOUN
gra-2156	65	9	,	,	PUNCT
gra-2156	65	10	advance	advance	NOUN
gra-2156	65	11	,	,	PUNCT
gra-2156	65	12	and	and	CCONJ
gra-2156	65	13	vadt	vadt	NOUN
gra-2156	65	14	found	find	VERB
gra-2156	65	15	that	that	SCONJ
gra-2156	65	16	intensive	intensive	ADJ
gra-2156	65	17	therapy	therapy	NOUN
gra-2156	65	18	of	of	ADP
gra-2156	65	19	older	old	ADJ
gra-2156	65	20	adults	adult	NOUN
gra-2156	65	21	with	with	ADP
gra-2156	65	22	type	type	NOUN
gra-2156	65	23	2	2	NUM
gra-2156	65	24	diabetes	diabete	NOUN
gra-2156	65	25	,	,	PUNCT
gra-2156	65	26	the	the	DET
gra-2156	65	27	majority	majority	NOUN
gra-2156	65	28	of	of	ADP
gra-2156	65	29	whom	whom	PRON
gra-2156	65	30	were	be	AUX
gra-2156	65	31	insulin	insulin	NOUN
gra-2156	65	32	-	-	PUNCT
gra-2156	65	33	treated	treat	VERB
gra-2156	65	34	and	and	CCONJ
gra-2156	65	35	followed	follow	VERB
gra-2156	65	36	for	for	ADP
gra-2156	65	37	a	a	DET
gra-2156	65	38	mean	mean	ADJ
gra-2156	65	39	3.5–5.6	3.5–5.6	NUM
gra-2156	65	40	years	year	NOUN
gra-2156	65	41	,	,	PUNCT
gra-2156	65	42	resulted	result	VERB
gra-2156	65	43	in	in	ADP
gra-2156	65	44	a	a	DET
gra-2156	65	45	10	10	NUM
gra-2156	65	46	%	%	NOUN
gra-2156	65	47	reduction	reduction	NOUN
gra-2156	65	48	in	in	ADP
gra-2156	65	49	microalbuminuria	microalbuminuria	PROPN
gra-2156	65	50	,	,	PUNCT
gra-2156	65	51	but	but	CCONJ
gra-2156	65	52	no	no	DET
gra-2156	65	53	signicant	signicant	ADJ
gra-2156	65	54	change	change	NOUN
gra-2156	65	55	in	in	ADP
gra-2156	65	56	other	other	ADJ
gra-2156	65	57	9microvascular	9microvascular	ADJ
gra-2156	65	58	complications	complication	NOUN
gra-2156	65	59	.	.	PUNCT
gra-2156	66	1	thus	thus	ADV
gra-2156	66	2	,	,	PUNCT
gra-2156	66	3	although	although	SCONJ
gra-2156	66	4	insulin	insulin	NOUN
gra-2156	66	5	has	have	AUX
gra-2156	66	6	been	be	AUX
gra-2156	66	7	shown	show	VERB
gra-2156	66	8	to	to	PART
gra-2156	66	9	have	have	AUX
gra-2156	66	10	both	both	CCONJ
gra-2156	66	11	cardioprotective	cardioprotective	ADJ
gra-2156	66	12	and	and	CCONJ
gra-2156	66	13	athero	athero	VERB
gra-2156	66	14	scl	scl	NOUN
gra-2156	66	15	erosis	erosis	ADV
gra-2156	66	16	-	-	PUNCT
gra-2156	66	17	promoting	promote	VERB
gra-2156	66	18	effects	effect	NOUN
gra-2156	66	19	in	in	ADP
gra-2156	66	20	laboratory	laboratory	NOUN
gra-2156	66	21	animal	animal	NOUN
gra-2156	66	22	studies	study	NOUN
gra-2156	66	23	,	,	PUNCT
gra-2156	66	24	human	human	ADJ
gra-2156	66	25	trials	trial	NOUN
gra-2156	66	26	have	have	AUX
gra-2156	66	27	not	not	PART
gra-2156	66	28	shown	show	VERB
gra-2156	66	29	insulin	insulin	NOUN
gra-2156	66	30	to	to	PART
gra-2156	66	31	increase	increase	VERB
gra-2156	66	32	cardiovascular	cardiovascular	ADJ
gra-2156	66	33	events	event	NOUN
gra-2156	66	34	and	and	CCONJ
gra-2156	66	35	need	need	VERB
gra-2156	66	36	further	far	ADV
gra-2156	66	37	in	in	ADP
gra-2156	66	38	-	-	PUNCT
gra-2156	66	39	depth	depth	NOUN
gra-2156	66	40	study	study	NOUN
gra-2156	66	41	.	.	PUNCT
gra-2156	67	1	conclusion	conclusion	NOUN
gra-2156	67	2	hypoglycemia	hypoglycemia	NOUN
gra-2156	67	3	is	be	AUX
gra-2156	67	4	considered	consider	VERB
gra-2156	67	5	to	to	PART
gra-2156	67	6	be	be	AUX
gra-2156	67	7	one	one	NUM
gra-2156	67	8	of	of	ADP
gra-2156	67	9	the	the	DET
gra-2156	67	10	major	major	ADJ
gra-2156	67	11	barriers	barrier	NOUN
gra-2156	67	12	in	in	ADP
gra-2156	67	13	initiating	initiate	VERB
gra-2156	67	14	insulin	insulin	NOUN
gra-2156	67	15	therapy	therapy	NOUN
gra-2156	67	16	and	and	CCONJ
gra-2156	67	17	is	be	AUX
gra-2156	67	18	often	often	ADV
gra-2156	67	19	a	a	DET
gra-2156	67	20	deciding	decide	VERB
gra-2156	67	21	factor	factor	NOUN
gra-2156	67	22	while	while	SCONJ
gra-2156	67	23	selecting	select	VERB
gra-2156	67	24	an	an	DET
gra-2156	67	25	insulin	insulin	NOUN
gra-2156	67	26	regimen	regiman	NOUN
gra-2156	67	27	.	.	PUNCT
gra-2156	68	1	therefore	therefore	ADV
gra-2156	68	2	,	,	PUNCT
gra-2156	68	3	it	it	PRON
gra-2156	68	4	makes	make	VERB
gra-2156	68	5	clinical	clinical	ADJ
gra-2156	68	6	sense	sense	NOUN
gra-2156	68	7	to	to	PART
gra-2156	68	8	adopt	adopt	VERB
gra-2156	68	9	a	a	DET
gra-2156	68	10	treatment	treatment	NOUN
gra-2156	68	11	regimen	regiman	NOUN
gra-2156	68	12	that	that	PRON
gra-2156	68	13	minimizes	minimize	VERB
gra-2156	68	14	this	this	DET
gra-2156	68	15	risk	risk	NOUN
gra-2156	68	16	.	.	PUNCT
gra-2156	69	1	iglar	iglar	NOUN
gra-2156	69	2	has	have	AUX
gra-2156	69	3	been	be	AUX
gra-2156	69	4	shown	show	VERB
gra-2156	69	5	to	to	PART
gra-2156	69	6	result	result	VERB
gra-2156	69	7	in	in	ADP
gra-2156	69	8	fewer	few	ADJ
gra-2156	69	9	hypoglycemic	hypoglycemic	ADJ
gra-2156	69	10	events	event	NOUN
gra-2156	69	11	than	than	ADP
gra-2156	69	12	nph	nph	NOUN
gra-2156	69	13	insulin	insulin	NOUN
gra-2156	69	14	,	,	PUNCT
gra-2156	69	15	along	along	ADP
gra-2156	69	16	with	with	ADP
gra-2156	69	17	comparable	comparable	ADJ
gra-2156	69	18	glycemic	glycemic	ADJ
gra-2156	69	19	control	control	NOUN
gra-2156	69	20	.	.	PUNCT
gra-2156	70	1	thus	thus	ADV
gra-2156	70	2	,	,	PUNCT
gra-2156	70	3	iglar	iglar	NOUN
gra-2156	70	4	-	-	PUNCT
gra-2156	70	5	is	be	AUX
gra-2156	70	6	the	the	DET
gra-2156	70	7	benchmark	benchmark	ADJ
gra-2156	70	8	basal	basal	NOUN
gra-2156	70	9	insulin	insulin	NOUN
gra-2156	70	10	and	and	CCONJ
gra-2156	70	11	may	may	AUX
gra-2156	70	12	continue	continue	VERB
gra-2156	70	13	to	to	PART
gra-2156	70	14	be	be	AUX
gra-2156	70	15	an	an	DET
gra-2156	70	16	important	important	ADJ
gra-2156	70	17	part	part	NOUN
gra-2156	70	18	of	of	ADP
gra-2156	70	19	treating	treat	VERB
gra-2156	70	20	t2	t2	PROPN
gra-2156	70	21	dm	dm	PROPN
gra-2156	70	22	.	.	PUNCT
gra-2156	71	1	references	reference	NOUN
gra-2156	71	2	1	1	NUM
gra-2156	71	3	.	.	PUNCT
gra-2156	72	1	kacerovsky	kacerovsky	PROPN
gra-2156	72	2	-	-	PUNCT
gra-2156	72	3	bielesz	bielesz	PROPN
gra-2156	72	4	g	g	NOUN
gra-2156	72	5	,	,	PUNCT
gra-2156	72	6	dressler	dressler	PROPN
gra-2156	72	7	a	a	PRON
gra-2156	72	8	,	,	PUNCT
gra-2156	72	9	freunscht	freunscht	PROPN
gra-2156	72	10	r.	r.	PROPN
gra-2156	72	11	long	long	ADJ
gra-2156	72	12	-	-	PUNCT
gra-2156	72	13	term	term	NOUN
gra-2156	72	14	glycaemic	glycaemic	NOUN
gra-2156	72	15	control	control	NOUN
gra-2156	72	16	with	with	ADP
gra-2156	72	17	insulin	insulin	NOUN
gra-2156	72	18	glargine	glargine	NOUN
gra-2156	72	19	in	in	ADP
gra-2156	72	20	type	type	NOUN
gra-2156	72	21	2	2	NUM
gra-2156	72	22	diabetes	diabetes	NOUN
gra-2156	72	23	.	.	PUNCT
gra-2156	73	1	diabetes	diabetes	NOUN
gra-2156	73	2	res	re	VERB
gra-2156	73	3	clin	clin	PROPN
gra-2156	73	4	pract	pract	PROPN
gra-2156	73	5	.	.	PUNCT
gra-2156	74	1	2006;71(2):184	2006;71(2):184	NUM
gra-2156	74	2	-	-	SYM
gra-2156	74	3	191	191	NUM
gra-2156	74	4	.	.	PUNCT
gra-2156	74	5	doi:10.1016	doi:10.1016	PROPN
gra-2156	74	6	/	/	SYM
gra-2156	74	7	j.diabres.2005.06.007	j.diabres.2005.06.007	PROPN
gra-2156	74	8	2	2	NUM
gra-2156	74	9	.	.	X
gra-2156	74	10	hirose	hirose	PROPN
gra-2156	74	11	t	t	PROPN
gra-2156	74	12	,	,	PUNCT
gra-2156	74	13	chen	chen	PROPN
gra-2156	74	14	cc	cc	PROPN
gra-2156	74	15	,	,	PUNCT
gra-2156	74	16	ahn	ahn	PROPN
gra-2156	74	17	kj	kj	PROPN
gra-2156	74	18	,	,	PUNCT
gra-2156	74	19	kilja	kilja	PROPN
gra-2156	74	20	�	�	PROPN
gra-2156	74	21	ski	ski	PROPN
gra-2156	74	22	j.	j.	PROPN
gra-2156	74	23	use	use	NOUN
gra-2156	74	24	of	of	ADP
gra-2156	74	25	insulin	insulin	NOUN
gra-2156	74	26	glargine	glargine	NOUN
gra-2156	74	27	100	100	NUM
gra-2156	74	28	u	u	NOUN
gra-2156	74	29	/	/	SYM
gra-2156	74	30	ml	ml	NOUN
gra-2156	74	31	for	for	ADP
gra-2156	74	32	the	the	DET
gra-2156	74	33	treatment	treatment	NOUN
gra-2156	74	34	of	of	ADP
gra-2156	74	35	type	type	NOUN
gra-2156	74	36	2	2	NUM
gra-2156	74	37	diabetes	diabetes	NOUN
gra-2156	74	38	mellitus	mellitus	NOUN
gra-2156	74	39	in	in	ADP
gra-2156	74	40	east	east	PROPN
gra-2156	74	41	asians	asians	PROPN
gra-2156	74	42	:	:	PUNCT
gra-2156	74	43	a	a	DET
gra-2156	74	44	review	review	NOUN
gra-2156	74	45	.	.	PUNCT
gra-2156	75	1	diabetes	diabetes	NOUN
gra-2156	75	2	ther	ther	ADV
gra-2156	75	3	.	.	PUNCT
gra-2156	76	1	2019;10(3):805	2019;10(3):805	NUM
gra-2156	76	2	-	-	PUNCT
gra-2156	76	3	833	833	NUM
gra-2156	76	4	.	.	PUNCT
gra-2156	77	1	doi:10.1007	doi:10.1007	VERB
gra-2156	77	2	/	/	SYM
gra-2156	77	3	s13300	s13300	NUM
gra-2156	77	4	-	-	PUNCT
gra-2156	77	5	019	019	NUM
gra-2156	77	6	-	-	PUNCT
gra-2156	77	7	0613	0613	NUM
gra-2156	77	8	-	-	SYM
gra-2156	77	9	7	7	NUM
gra-2156	77	10	3	3	NUM
gra-2156	77	11	.	.	PUNCT
gra-2156	78	1	agarwal	agarwal	PROPN
gra-2156	78	2	sk	sk	PROPN
gra-2156	78	3	,	,	PUNCT
gra-2156	78	4	singh	singh	PROPN
gra-2156	78	5	bk	bk	PROPN
gra-2156	78	6	,	,	PUNCT
gra-2156	78	7	wadhwa	wadhwa	PROPN
gra-2156	78	8	r.	r.	PROPN
gra-2156	78	9	insulin	insulin	PROPN
gra-2156	78	10	glargine	glargine	NOUN
gra-2156	78	11	as	as	ADP
gra-2156	78	12	add	add	ADJ
gra-2156	78	13	-	-	PUNCT
gra-2156	78	14	on	on	ADP
gra-2156	78	15	therapy	therapy	NOUN
gra-2156	78	16	to	to	ADP
gra-2156	78	17	oral	oral	ADJ
gra-2156	78	18	hypoglycaemic	hypoglycaemic	ADJ
gra-2156	78	19	agents	agent	NOUN
gra-2156	78	20	to	to	PART
gra-2156	78	21	achieve	achieve	VERB
gra-2156	78	22	target	target	NOUN
gra-2156	78	23	fasting	fast	VERB
gra-2156	78	24	plasma	plasma	NOUN
gra-2156	78	25	glucose	glucose	NOUN
gra-2156	78	26	levels	level	NOUN
gra-2156	78	27	in	in	ADP
gra-2156	78	28	type	type	NOUN
gra-2156	78	29	2	2	NUM
gra-2156	78	30	diabetes	diabetes	NOUN
gra-2156	78	31	patients	patient	NOUN
gra-2156	78	32	in	in	ADP
gra-2156	78	33	an	an	DET
gra-2156	78	34	indian	indian	ADJ
gra-2156	78	35	setup	setup	NOUN
gra-2156	78	36	.	.	PUNCT
gra-2156	79	1	indian	indian	PROPN
gra-2156	79	2	j	j	PROPN
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gra-2156	80	4	.	.	PUNCT
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gra-2156	83	4	.	.	PUNCT
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gra-2156	84	5	.	.	PUNCT
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gra-2156	87	2	-	-	SYM
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gra-2156	87	4	.	.	PUNCT
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gra-2156	88	18	2	2	NUM
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gra-2156	89	1	2004;(59	2004;(59	NUM
gra-2156	89	2	)	)	PUNCT
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gra-2156	90	2	.	.	X
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gra-2156	90	22	in	in	ADP
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gra-2156	90	31	in	in	ADP
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gra-2156	90	35	.	.	PUNCT
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gra-2156	92	2	-	-	SYM
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gra-2156	92	4	.	.	PUNCT
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gra-2156	93	2	/	/	SYM
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gra-2156	94	5	.	.	PUNCT
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gra-2156	94	11	,	,	PUNCT
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gra-2156	94	26	nocturnal	nocturnal	ADJ
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gra-2156	94	28	in	in	ADP
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gra-2156	94	30	with	with	ADP
gra-2156	94	31	type	type	NOUN
gra-2156	94	32	2	2	NUM
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gra-2156	94	34	mellitus	mellitus	NOUN
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gra-2156	94	40	3	3	NUM
gra-2156	94	41	and	and	CCONJ
gra-2156	94	42	4	4	NUM
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gra-2156	95	2	-	-	PUNCT
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gra-2156	95	4	.	.	PUNCT
gra-2156	96	1	doi:10.1016	doi:10.1016	PROPN
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gra-2156	96	5	.	.	PUNCT
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gra-2156	97	11	in	in	ADP
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gra-2156	98	5	.	.	PUNCT
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gra-2156	99	2	.	.	PUNCT
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gra-2156	100	2	,	,	PUNCT
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gra-2156	100	12	8160	8160	NUM
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