id	sid	tid	token	lemma	pos
gra-2159	1	1	16.bluetree	16.bluetree	NUM
gra-2159	1	2	03.cdr	03.cdr	NOUN
gra-2159	1	3	the	the	DET
gra-2159	1	4	number	number	NOUN
gra-2159	1	5	of	of	ADP
gra-2159	1	6	patients	patient	NOUN
gra-2159	1	7	with	with	ADP
gra-2159	1	8	type	type	NOUN
gra-2159	1	9	2	2	NUM
gra-2159	1	10	diabetes	diabetes	NOUN
gra-2159	1	11	is	be	AUX
gra-2159	1	12	rapidly	rapidly	ADV
gra-2159	1	13	increasing	increase	VERB
gra-2159	1	14	,	,	PUNCT
gra-2159	1	15	and	and	CCONJ
gra-2159	1	16	type	type	NOUN
gra-2159	1	17	2	2	NUM
gra-2159	1	18	diabetes	diabetes	NOUN
gra-2159	1	19	is	be	AUX
gra-2159	1	20	one	one	NUM
gra-2159	1	21	of	of	ADP
gra-2159	1	22	the	the	DET
gra-2159	1	23	most	most	ADV
gra-2159	1	24	common	common	ADJ
gra-2159	1	25	chronic	chronic	ADJ
gra-2159	1	26	diseases	disease	NOUN
gra-2159	1	27	.	.	PUNCT
gra-2159	2	1	diabetic	diabetic	ADJ
gra-2159	2	2	kidney	kidney	NOUN
gra-2159	2	3	disease	disease	NOUN
gra-2159	2	4	(	(	PUNCT
gra-2159	2	5	dkd	dkd	ADJ
gra-2159	2	6	)	)	PUNCT
gra-2159	2	7	is	be	AUX
gra-2159	2	8	among	among	ADP
gra-2159	2	9	the	the	DET
gra-2159	2	10	most	most	ADV
gra-2159	2	11	important	important	ADJ
gra-2159	2	12	complications	complication	NOUN
gra-2159	2	13	of	of	ADP
gra-2159	2	14	diabetes	diabetes	NOUN
gra-2159	2	15	and	and	CCONJ
gra-2159	2	16	often	often	ADV
gra-2159	2	17	leads	lead	VERB
gra-2159	2	18	to	to	ADP
gra-2159	2	19	the	the	DET
gra-2159	2	20	need	need	NOUN
gra-2159	2	21	for	for	ADP
gra-2159	2	22	renal	renal	ADJ
gra-2159	2	23	replacement	replacement	NOUN
gra-2159	2	24	therapy	therapy	NOUN
gra-2159	2	25	,	,	PUNCT
gra-2159	2	26	including	include	VERB
gra-2159	2	27	dialysis	dialysis	NOUN
gra-2159	2	28	and	and	CCONJ
gra-2159	2	29	1renal	1renal	NUM
gra-2159	2	30	replacement	replacement	NOUN
gra-2159	2	31	.	.	PUNCT
gra-2159	3	1	thus	thus	ADV
gra-2159	3	2	,	,	PUNCT
gra-2159	3	3	patients	patient	NOUN
gra-2159	3	4	with	with	ADP
gra-2159	3	5	diabetes	diabetes	NOUN
gra-2159	3	6	represent	represent	VERB
gra-2159	3	7	a	a	DET
gra-2159	3	8	signicant	signicant	ADJ
gra-2159	3	9	global	global	ADJ
gra-2159	3	10	health	health	NOUN
gra-2159	3	11	burden	burden	NOUN
gra-2159	3	12	.	.	PUNCT
gra-2159	4	1	the	the	DET
gra-2159	4	2	increasing	increase	VERB
gra-2159	4	3	incidence	incidence	NOUN
gra-2159	4	4	and	and	CCONJ
gra-2159	4	5	prevalence	prevalence	NOUN
gra-2159	4	6	of	of	ADP
gra-2159	4	7	dkd	dkd	ADJ
gra-2159	4	8	places	place	NOUN
gra-2159	4	9	signicant	signicant	ADJ
gra-2159	4	10	health	health	NOUN
gra-2159	4	11	burdens	burden	NOUN
gra-2159	4	12	on	on	ADP
gra-2159	4	13	2patients	2patients	NUM
gra-2159	4	14	and	and	CCONJ
gra-2159	4	15	costs	cost	NOUN
gra-2159	4	16	on	on	ADP
gra-2159	4	17	our	our	PRON
gra-2159	4	18	already	already	ADV
gra-2159	4	19	stressed	stress	VERB
gra-2159	4	20	healthcare	healthcare	NOUN
gra-2159	4	21	system	system	NOUN
gra-2159	4	22	.	.	PUNCT
gra-2159	5	1	the	the	DET
gra-2159	5	2	diabetes	diabetes	NOUN
gra-2159	5	3	control	control	NOUN
gra-2159	5	4	and	and	CCONJ
gra-2159	5	5	complications	complication	NOUN
gra-2159	5	6	trial	trial	NOUN
gra-2159	5	7	(	(	PUNCT
gra-2159	5	8	dcct	dcct	ADJ
gra-2159	5	9	)	)	PUNCT
gra-2159	5	10	,	,	PUNCT
gra-2159	5	11	performed	perform	VERB
gra-2159	5	12	in	in	ADP
gra-2159	5	13	patients	patient	NOUN
gra-2159	5	14	with	with	ADP
gra-2159	5	15	type	type	NOUN
gra-2159	5	16	1	1	NUM
gra-2159	5	17	diabetes	diabetes	NOUN
gra-2159	5	18	,	,	PUNCT
gra-2159	5	19	and	and	CCONJ
gra-2159	5	20	the	the	DET
gra-2159	5	21	united	united	ADJ
gra-2159	5	22	kingdom	kingdom	PROPN
gra-2159	5	23	prospective	prospective	ADJ
gra-2159	5	24	diabetes	diabetes	NOUN
gra-2159	5	25	study	study	NOUN
gra-2159	5	26	(	(	PUNCT
gra-2159	5	27	ukpds	ukpds	PROPN
gra-2159	5	28	)	)	PUNCT
gra-2159	5	29	,	,	PUNCT
gra-2159	5	30	in	in	ADP
gra-2159	5	31	patients	patient	NOUN
gra-2159	5	32	with	with	ADP
gra-2159	5	33	type	type	NOUN
gra-2159	5	34	2	2	NUM
gra-2159	5	35	diabetes	diabetes	NOUN
gra-2159	5	36	,	,	PUNCT
gra-2159	5	37	revealed	reveal	VERB
gra-2159	5	38	that	that	SCONJ
gra-2159	5	39	intensive	intensive	ADJ
gra-2159	5	40	glycemic	glycemic	ADJ
gra-2159	5	41	control	control	NOUN
gra-2159	5	42	might	might	AUX
gra-2159	5	43	inhibit	inhibit	VERB
gra-2159	5	44	the	the	DET
gra-2159	5	45	progression	progression	NOUN
gra-2159	5	46	of	of	ADP
gra-2159	5	47	dkd	dkd	PROPN
gra-2159	5	48	.	.	PUNCT
gra-2159	6	1	thus	thus	ADV
gra-2159	6	2	,	,	PUNCT
gra-2159	6	3	hyperglycemia	hyperglycemia	NOUN
gra-2159	6	4	could	could	AUX
gra-2159	6	5	be	be	AUX
gra-2159	6	6	a	a	DET
gra-2159	6	7	major	major	ADJ
gra-2159	6	8	factor	factor	NOUN
gra-2159	6	9	in	in	ADP
gra-2159	6	10	the	the	DET
gra-2159	6	11	progression	progression	NOUN
gra-2159	6	12	of	of	ADP
gra-2159	6	13	dkd	dkd	PROPN
gra-2159	6	14	.	.	PUNCT
gra-2159	7	1	however	however	ADV
gra-2159	7	2	,	,	PUNCT
gra-2159	7	3	dkd	dkd	PROPN
gra-2159	7	4	develops	develop	VERB
gra-2159	7	5	despite	despite	SCONJ
gra-2159	7	6	good	good	ADJ
gra-2159	7	7	glycemic	glycemic	ADJ
gra-2159	7	8	control	control	NOUN
gra-2159	7	9	.	.	PUNCT
gra-2159	8	1	thus	thus	ADV
gra-2159	8	2	,	,	PUNCT
gra-2159	8	3	novel	novel	ADJ
gra-2159	8	4	therapeutic	therapeutic	ADJ
gra-2159	8	5	agents	agent	NOUN
gra-2159	8	6	beyond	beyond	ADP
gra-2159	8	7	those	those	PRON
gra-2159	8	8	for	for	ADP
gra-2159	8	9	glycemic	glycemic	ADJ
gra-2159	8	10	control	control	NOUN
gra-2159	8	11	in	in	ADP
gra-2159	8	12	1patients	1patients	NUM
gra-2159	8	13	with	with	ADP
gra-2159	8	14	dkd	dkd	PROPN
gra-2159	8	15	are	be	AUX
gra-2159	8	16	needed	need	VERB
gra-2159	8	17	.	.	PUNCT
gra-2159	9	1	there	there	PRON
gra-2159	9	2	are	be	VERB
gra-2159	9	3	about	about	ADV
gra-2159	9	4	200	200	NUM
gra-2159	9	5	million	million	NUM
gra-2159	9	6	people	people	NOUN
gra-2159	9	7	in	in	ADP
gra-2159	9	8	the	the	DET
gra-2159	9	9	world	world	NOUN
gra-2159	9	10	with	with	ADP
gra-2159	9	11	dkd	dkd	ADJ
gra-2159	9	12	in	in	ADP
gra-2159	9	13	different	different	ADJ
gra-2159	9	14	stages	stage	NOUN
gra-2159	9	15	,	,	PUNCT
gra-2159	9	16	and	and	CCONJ
gra-2159	9	17	hypertension	hypertension	NOUN
gra-2159	9	18	,	,	PUNCT
gra-2159	9	19	arteriosclerosis	arteriosclerosis	NOUN
gra-2159	9	20	and	and	CCONJ
gra-2159	9	21	diabetes	diabetes	NOUN
gra-2159	9	22	mellitus	mellitus	NOUN
gra-2159	9	23	are	be	AUX
gra-2159	9	24	responsible	responsible	ADJ
gra-2159	9	25	for	for	ADP
gra-2159	9	26	over	over	ADP
gra-2159	9	27	50	50	NUM
gra-2159	9	28	%	%	NOUN
gra-2159	9	29	of	of	ADP
gra-2159	9	30	end	end	NOUN
gra-2159	9	31	-	-	PUNCT
gra-2159	9	32	stage	stage	NOUN
gra-2159	9	33	renal	renal	ADJ
gra-2159	9	34	disease	disease	NOUN
gra-2159	9	35	.	.	PUNCT
gra-2159	10	1	about	about	ADV
gra-2159	10	2	40	40	NUM
gra-2159	10	3	%	%	NOUN
gra-2159	10	4	of	of	ADP
gra-2159	10	5	patients	patient	NOUN
gra-2159	10	6	with	with	ADP
gra-2159	10	7	(	(	PUNCT
gra-2159	10	8	diagnosed	diagnose	VERB
gra-2159	10	9	or	or	CCONJ
gra-2159	10	10	not	not	PART
gra-2159	10	11	)	)	PUNCT
gra-2159	10	12	diabetes	diabetes	NOUN
gra-2159	10	13	mellitus	mellitus	NOUN
gra-2159	10	14	has	have	VERB
gra-2159	10	15	an	an	DET
gra-2159	10	16	advanced	advanced	ADJ
gra-2159	10	17	stage	stage	NOUN
gra-2159	10	18	of	of	ADP
gra-2159	10	19	kidney	kidney	NOUN
gra-2159	10	20	disease	disease	NOUN
gra-2159	10	21	,	,	PUNCT
gra-2159	10	22	often	often	ADV
gra-2159	10	23	because	because	SCONJ
gra-2159	10	24	of	of	ADP
gra-2159	10	25	serious	serious	ADJ
gra-2159	10	26	deciencies	deciencie	NOUN
gra-2159	10	27	in	in	ADP
gra-2159	10	28	the	the	DET
gra-2159	10	29	management	management	NOUN
gra-2159	10	30	of	of	ADP
gra-2159	10	31	the	the	DET
gra-2159	10	32	disease	disease	NOUN
gra-2159	10	33	itself	itself	PRON
gra-2159	10	34	.	.	PUNCT
gra-2159	11	1	in	in	ADP
gra-2159	11	2	patients	patient	NOUN
gra-2159	11	3	with	with	ADP
gra-2159	11	4	diabetes	diabetes	NOUN
gra-2159	11	5	mellitus	mellitus	NOUN
gra-2159	11	6	,	,	PUNCT
gra-2159	11	7	kidney	kidney	NOUN
gra-2159	11	8	disease	disease	NOUN
gra-2159	11	9	occurs	occur	VERB
gra-2159	11	10	and	and	CCONJ
gra-2159	11	11	often	often	ADV
gra-2159	11	12	develops	develop	VERB
gra-2159	11	13	insidiously	insidiously	ADJ
gra-2159	11	14	;	;	PUNCT
gra-2159	11	15	the	the	DET
gra-2159	11	16	main	main	ADJ
gra-2159	11	17	renal	renal	ADJ
gra-2159	11	18	dysfunctions	dysfunction	NOUN
gra-2159	11	19	are	be	AUX
gra-2159	11	20	due	due	ADJ
gra-2159	11	21	to	to	ADP
gra-2159	11	22	the	the	DET
gra-2159	11	23	thickening	thickening	NOUN
gra-2159	11	24	of	of	ADP
gra-2159	11	25	the	the	DET
gra-2159	11	26	glomerular	glomerular	ADJ
gra-2159	11	27	basement	basement	NOUN
gra-2159	11	28	membranes	membrane	NOUN
gra-2159	11	29	,	,	PUNCT
gra-2159	11	30	the	the	DET
gra-2159	11	31	formation	formation	NOUN
gra-2159	11	32	of	of	ADP
gra-2159	11	33	microaneurysms	microaneurysm	NOUN
gra-2159	11	34	and	and	CCONJ
gra-2159	11	35	the	the	DET
gra-2159	11	36	development	development	NOUN
gra-2159	11	37	of	of	ADP
gra-2159	11	38	3mesangial	3mesangial	NUM
gra-2159	11	39	nodules	nodule	NOUN
gra-2159	11	40	.	.	PUNCT
gra-2159	12	1	the	the	DET
gra-2159	12	2	onset	onset	NOUN
gra-2159	12	3	of	of	ADP
gra-2159	12	4	a	a	DET
gra-2159	12	5	clinically	clinically	ADV
gra-2159	12	6	documented	document	VERB
gra-2159	12	7	diabetic	diabetic	ADJ
gra-2159	12	8	nephropathy	nephropathy	NOUN
gra-2159	12	9	is	be	AUX
gra-2159	12	10	generally	generally	ADV
gra-2159	12	11	preceded	precede	VERB
gra-2159	12	12	by	by	ADP
gra-2159	12	13	the	the	DET
gra-2159	12	14	4appearance	4appearance	PROPN
gra-2159	12	15	of	of	ADP
gra-2159	12	16	proteinuria	proteinuria	NOUN
gra-2159	12	17	greater	great	ADJ
gra-2159	12	18	than	than	ADP
gra-2159	12	19	500	500	NUM
gra-2159	12	20	mg	mg	NUM
gra-2159	12	21	/	/	SYM
gra-2159	12	22	day	day	NOUN
gra-2159	12	23	.	.	PUNCT
gra-2159	13	1	conventional	conventional	ADJ
gra-2159	13	2	therapies	therapy	NOUN
gra-2159	13	3	used	use	VERB
gra-2159	13	4	in	in	ADP
gra-2159	13	5	patients	patient	NOUN
gra-2159	13	6	with	with	ADP
gra-2159	13	7	type	type	NOUN
gra-2159	13	8	2	2	NUM
gra-2159	13	9	diabetes	diabetes	NOUN
gra-2159	13	10	mell	mell	NOUN
gra-2159	13	11	i	i	PRON
gra-2159	13	12	tus	tus	PROPN
gra-2159	13	13	include	include	VERB
gra-2159	13	14	medications	medication	NOUN
gra-2159	13	15	such	such	ADJ
gra-2159	13	16	as	as	ADP
gra-2159	13	17	metformin	metformin	NOUN
gra-2159	13	18	,	,	PUNCT
gra-2159	13	19	sulphonylureas	sulphonylurea	NOUN
gra-2159	13	20	,	,	PUNCT
gra-2159	13	21	thiazolidinediones	thiazolidinedione	NOUN
gra-2159	13	22	,	,	PUNCT
gra-2159	13	23	meglitinides	meglitinide	NOUN
gra-2159	13	24	,	,	PUNCT
gra-2159	13	25	and	and	CCONJ
gra-2159	13	26	insulin	insulin	NOUN
gra-2159	13	27	.	.	PUNCT
gra-2159	14	1	except	except	SCONJ
gra-2159	14	2	for	for	ADP
gra-2159	14	3	pioglitazone	pioglitazone	NOUN
gra-2159	14	4	,	,	PUNCT
gra-2159	14	5	which	which	PRON
gra-2159	14	6	is	be	AUX
gra-2159	14	7	a	a	DET
gra-2159	14	8	thiazolidinedione	thiazolidinedione	ADJ
gra-2159	14	9	,	,	PUNCT
gra-2159	14	10	all	all	DET
gra-2159	14	11	other	other	ADJ
gra-2159	14	12	drugs	drug	NOUN
gra-2159	14	13	require	require	VERB
gra-2159	14	14	dose	dose	NOUN
gra-2159	14	15	adjustments	adjustment	NOUN
gra-2159	14	16	and	and	CCONJ
gra-2159	14	17	an	an	DET
gra-2159	14	18	immediate	immediate	ADJ
gra-2159	14	19	suspension	suspension	NOUN
gra-2159	14	20	in	in	ADP
gra-2159	14	21	patients	patient	NOUN
gra-2159	14	22	with	with	ADP
gra-2159	14	23	a	a	DET
gra-2159	14	24	reduction	reduction	NOUN
gra-2159	14	25	in	in	ADP
gra-2159	14	26	the	the	DET
gra-2159	14	27	glomerular	glomerular	ADJ
gra-2159	14	28	ltration	ltration	NOUN
gra-2159	14	29	rate	rate	NOUN
gra-2159	14	30	(	(	PUNCT
gra-2159	14	31	egfr	egfr	NOUN
gra-2159	14	32	)	)	PUNCT
gra-2159	14	33	.	.	PUNCT
gra-2159	15	1	in	in	ADP
gra-2159	15	2	these	these	DET
gra-2159	15	3	cases	case	NOUN
gra-2159	15	4	,	,	PUNCT
gra-2159	15	5	in	in	ADP
gra-2159	15	6	fact	fact	NOUN
gra-2159	15	7	,	,	PUNCT
gra-2159	15	8	there	there	PRON
gra-2159	15	9	is	be	VERB
gra-2159	15	10	the	the	DET
gra-2159	15	11	risk	risk	NOUN
gra-2159	15	12	of	of	ADP
gra-2159	15	13	development	development	NOUN
gra-2159	15	14	of	of	ADP
gra-2159	15	15	lactic	lactic	ADJ
gra-2159	15	16	acidosis	acidosis	NOUN
gra-2159	15	17	(	(	PUNCT
gra-2159	15	18	metformin	metformin	NOUN
gra-2159	15	19	)	)	PUNCT
gra-2159	15	20	or	or	CCONJ
gra-2159	15	21	hypoglycaemic	hypoglycaemic	ADJ
gra-2159	15	22	3episodes	3episodes	NUM
gra-2159	15	23	(	(	PUNCT
gra-2159	15	24	sulfonylureas	sulfonylureas	PROPN
gra-2159	15	25	,	,	PUNCT
gra-2159	15	26	meglitinides	meglitinide	NOUN
gra-2159	15	27	,	,	PUNCT
gra-2159	15	28	and	and	CCONJ
gra-2159	15	29	insulin	insulin	NOUN
gra-2159	15	30	)	)	PUNCT
gra-2159	15	31	.	.	PUNCT
gra-2159	16	1	some	some	DET
gra-2159	16	2	reports	report	NOUN
gra-2159	16	3	suggest	suggest	VERB
gra-2159	16	4	that	that	SCONJ
gra-2159	16	5	hyperglycemia	hyperglycemia	NOUN
gra-2159	16	6	may	may	AUX
gra-2159	16	7	play	play	VERB
gra-2159	16	8	a	a	DET
gra-2159	16	9	signicant	signicant	ADJ
gra-2159	16	10	role	role	NOUN
gra-2159	16	11	in	in	ADP
gra-2159	16	12	the	the	DET
gra-2159	16	13	development	development	NOUN
gra-2159	16	14	of	of	ADP
gra-2159	16	15	dkd	dkd	ADJ
gra-2159	16	16	;	;	PUNCT
gra-2159	16	17	thus	thus	ADV
gra-2159	16	18	,	,	PUNCT
gra-2159	16	19	appropriate	appropriate	ADJ
gra-2159	16	20	glycemic	glycemic	ADJ
gra-2159	16	21	control	control	NOUN
gra-2159	16	22	seems	seem	VERB
gra-2159	16	23	to	to	PART
gra-2159	16	24	protect	protect	VERB
gra-2159	16	25	against	against	ADP
gra-2159	16	26	dkd	dkd	PROPN
gra-2159	16	27	.	.	PUNCT
gra-2159	17	1	several	several	ADJ
gra-2159	17	2	large	large	ADJ
gra-2159	17	3	clinical	clinical	ADJ
gra-2159	17	4	trials	trial	NOUN
gra-2159	17	5	such	such	ADJ
gra-2159	17	6	as	as	ADP
gra-2159	17	7	dcct	dcct	ADJ
gra-2159	17	8	and	and	CCONJ
gra-2159	17	9	ukpds	ukpds	PROPN
gra-2159	17	10	have	have	AUX
gra-2159	17	11	shown	show	VERB
gra-2159	17	12	that	that	SCONJ
gra-2159	17	13	intensive	intensive	ADJ
gra-2159	17	14	glycemic	glycemic	ADJ
gra-2159	17	15	control	control	NOUN
gra-2159	17	16	in	in	ADP
gra-2159	17	17	patients	patient	NOUN
gra-2159	17	18	with	with	ADP
gra-2159	17	19	type	type	NOUN
gra-2159	17	20	1	1	NUM
gra-2159	17	21	or	or	CCONJ
gra-2159	17	22	2	2	NUM
gra-2159	17	23	diabetes	diabetes	NOUN
gra-2159	17	24	could	could	AUX
gra-2159	17	25	delay	delay	VERB
gra-2159	17	26	the	the	DET
gra-2159	17	27	development	development	NOUN
gra-2159	17	28	of	of	ADP
gra-2159	17	29	dkd	dkd	PROPN
gra-2159	17	30	.	.	PUNCT
gra-2159	18	1	in	in	ADP
gra-2159	18	2	contrast	contrast	NOUN
gra-2159	18	3	,	,	PUNCT
gra-2159	18	4	recent	recent	ADJ
gra-2159	18	5	studies	study	NOUN
gra-2159	18	6	have	have	AUX
gra-2159	18	7	indicated	indicate	VERB
gra-2159	18	8	that	that	SCONJ
gra-2159	18	9	intensive	intensive	ADJ
gra-2159	18	10	glycemic	glycemic	ADJ
gra-2159	18	11	control	control	NOUN
gra-2159	18	12	reduces	reduce	VERB
gra-2159	18	13	albuminuria	albuminuria	NOUN
gra-2159	18	14	and	and	CCONJ
gra-2159	18	15	proteinuria	proteinuria	NOUN
gra-2159	18	16	but	but	CCONJ
gra-2159	18	17	can	can	AUX
gra-2159	18	18	not	not	PART
gra-2159	18	19	improve	improve	VERB
gra-2159	18	20	renal	renal	ADJ
gra-2159	18	21	outcomes	outcome	NOUN
gra-2159	18	22	.	.	PUNCT
gra-2159	19	1	furthermore	furthermore	ADV
gra-2159	19	2	,	,	PUNCT
gra-2159	19	3	hypoglycemia	hypoglycemia	NOUN
gra-2159	19	4	exacerbates	exacerbate	VERB
gra-2159	19	5	both	both	DET
gra-2159	19	6	macroand	macroand	NOUN
gra-2159	19	7	microvascular	microvascular	NOUN
gra-2159	19	8	complications	complication	NOUN
gra-2159	19	9	,	,	PUNCT
gra-2159	19	10	including	include	VERB
gra-2159	19	11	dkd	dkd	PROPN
gra-2159	19	12	.	.	PUNCT
gra-2159	19	13	1thus	1thus	NUM
gra-2159	19	14	,	,	PUNCT
gra-2159	19	15	glycemic	glycemic	ADJ
gra-2159	19	16	control	control	NOUN
gra-2159	19	17	is	be	AUX
gra-2159	19	18	insufcient	insufcient	ADJ
gra-2159	19	19	to	to	PART
gra-2159	19	20	prevent	prevent	VERB
gra-2159	19	21	dkd	dkd	NOUN
gra-2159	19	22	.	.	PUNCT
gra-2159	20	1	in	in	ADP
gra-2159	20	2	recent	recent	ADJ
gra-2159	20	3	years	year	NOUN
gra-2159	20	4	,	,	PUNCT
gra-2159	20	5	there	there	PRON
gra-2159	20	6	have	have	AUX
gra-2159	20	7	been	be	AUX
gra-2159	20	8	several	several	ADJ
gra-2159	20	9	new	new	ADJ
gra-2159	20	10	categories	category	NOUN
gra-2159	20	11	of	of	ADP
gra-2159	20	12	medications	medication	NOUN
gra-2159	20	13	approved	approve	VERB
gra-2159	20	14	for	for	ADP
gra-2159	20	15	the	the	DET
gra-2159	20	16	treatment	treatment	NOUN
gra-2159	20	17	of	of	ADP
gra-2159	20	18	diabetes	diabetes	NOUN
gra-2159	20	19	,	,	PUNCT
gra-2159	20	20	including	include	VERB
gra-2159	20	21	new	new	ADJ
gra-2159	20	22	insulins	insulin	NOUN
gra-2159	20	23	,	,	PUNCT
gra-2159	20	24	glucagon	glucagon	NOUN
gra-2159	20	25	-	-	PUNCT
gra-2159	20	26	like	like	ADJ
gra-2159	20	27	peptide-1	peptide-1	NOUN
gra-2159	20	28	receptor	receptor	NOUN
gra-2159	20	29	agonists	agonist	NOUN
gra-2159	20	30	(	(	PUNCT
gra-2159	20	31	glp1	glp1	PROPN
gra-2159	20	32	ras	ras	PROPN
gra-2159	20	33	)	)	PUNCT
gra-2159	20	34	,	,	PUNCT
gra-2159	20	35	dipeptidyl	dipeptidyl	VERB
gra-2159	20	36	peptidase-4	peptidase-4	NUM
gra-2159	20	37	inhibitors	inhibitor	NOUN
gra-2159	20	38	(	(	PUNCT
gra-2159	20	39	dpp-4i	dpp-4i	PROPN
gra-2159	20	40	)	)	PUNCT
gra-2159	20	41	,	,	PUNCT
gra-2159	20	42	an	an	DET
gra-2159	20	43	amylin	amylin	NOUN
gra-2159	20	44	analog	analog	NOUN
gra-2159	20	45	,	,	PUNCT
gra-2159	20	46	and	and	CCONJ
gra-2159	20	47	sodium	sodium	NOUN
gra-2159	20	48	-	-	PUNCT
gra-2159	20	49	glucose	glucose	NOUN
gra-2159	20	50	cotransporter-2	cotransporter-2	NUM
gra-2159	20	51	inhibitors	inhibitor	NOUN
gra-2159	20	52	(	(	PUNCT
gra-2159	20	53	sglt-2i	sglt-2i	PROPN
gra-2159	20	54	)	)	PUNCT
gra-2159	20	55	.	.	PUNCT
gra-2159	21	1	two	two	NUM
gra-2159	21	2	classes	class	NOUN
gra-2159	21	3	of	of	ADP
gra-2159	21	4	oral	oral	ADJ
gra-2159	21	5	medications	medication	NOUN
gra-2159	21	6	,	,	PUNCT
gra-2159	21	7	dpp-4i	dpp-4i	VERB
gra-2159	21	8	and	and	CCONJ
gra-2159	21	9	sglt2i	sglt2i	PROPN
gra-2159	21	10	,	,	PUNCT
gra-2159	21	11	are	be	AUX
gra-2159	21	12	potentially	potentially	ADV
gra-2159	21	13	considered	consider	VERB
gra-2159	21	14	as	as	ADP
gra-2159	21	15	options	option	NOUN
gra-2159	21	16	for	for	ADP
gra-2159	21	17	add	add	VERB
gra-2159	21	18	-	-	PUNCT
gra-2159	21	19	on	on	ADP
gra-2159	21	20	therapy	therapy	NOUN
gra-2159	21	21	to	to	PART
gra-2159	21	22	metformin	metformin	VERB
gra-2159	21	23	for	for	ADP
gra-2159	21	24	the	the	DET
gra-2159	21	25	management	management	NOUN
gra-2159	21	26	of	of	ADP
gra-2159	21	27	diabetic	diabetic	ADJ
gra-2159	21	28	kidney	kidney	NOUN
gra-2159	21	29	.	.	PUNCT
gra-2159	22	1	dpp-4i	dpp-4i	VERB
gra-2159	22	2	acts	act	VERB
gra-2159	22	3	via	via	ADP
gra-2159	22	4	inhibiting	inhibit	VERB
gra-2159	22	5	the	the	PRON
gra-2159	22	6	dpp-4	dpp-4	ADJ
gra-2159	22	7	enzyme	enzyme	NOUN
gra-2159	22	8	thus	thus	ADV
gra-2159	22	9	prolonging	prolong	VERB
gra-2159	22	10	glucagonlike	glucagonlike	NOUN
gra-2159	22	11	peptide-1	peptide-1	NOUN
gra-2159	22	12	and	and	CCONJ
gra-2159	22	13	glucose	glucose	NOUN
gra-2159	22	14	-	-	PUNCT
gra-2159	22	15	dependent	dependent	ADJ
gra-2159	22	16	insulinotropic	insulinotropic	NOUN
gra-2159	22	17	polypeptide	polypeptide	ADJ
gra-2159	22	18	activity	activity	NOUN
gra-2159	22	19	.	.	PUNCT
gra-2159	23	1	sodium	sodium	NOUN
gra-2159	23	2	-	-	PUNCT
gra-2159	23	3	glucose	glucose	NOUN
gra-2159	23	4	linked	link	VERB
gra-2159	23	5	cotransporters	cotransporter	NOUN
gra-2159	23	6	(	(	PUNCT
gra-2159	23	7	sglt	sglt	ADJ
gra-2159	23	8	)	)	PUNCT
gra-2159	23	9	is	be	AUX
gra-2159	23	10	expressed	express	VERB
gra-2159	23	11	in	in	ADP
gra-2159	23	12	the	the	DET
gra-2159	23	13	proximal	proximal	ADJ
gra-2159	23	14	tubule	tubule	NOUN
gra-2159	23	15	and	and	CCONJ
gra-2159	23	16	are	be	AUX
gra-2159	23	17	of	of	ADP
gra-2159	23	18	two	two	NUM
gra-2159	23	19	isoforms	isoform	NOUN
gra-2159	23	20	:	:	PUNCT
gra-2159	23	21	sglt1	sglt1	NOUN
gra-2159	23	22	and	and	CCONJ
gra-2159	23	23	sglt2	sglt2	PROPN
gra-2159	23	24	.	.	PUNCT
gra-2159	24	1	in	in	ADP
gra-2159	24	2	particular	particular	ADJ
gra-2159	24	3	,	,	PUNCT
gra-2159	24	4	sglt2	sglt2	X
gra-2159	24	5	is	be	AUX
gra-2159	24	6	a	a	DET
gra-2159	24	7	high	high	ADJ
gra-2159	24	8	-	-	PUNCT
gra-2159	24	9	capacity	capacity	NOUN
gra-2159	24	10	,	,	PUNCT
gra-2159	24	11	low	low	ADJ
gra-2159	24	12	-	-	PUNCT
gra-2159	24	13	afnity	afnity	NOUN
gra-2159	24	14	glucose	glucose	NOUN
gra-2159	24	15	transporter	transporter	NOUN
gra-2159	24	16	that	that	PRON
gra-2159	24	17	is	be	AUX
gra-2159	24	18	expressed	express	VERB
gra-2159	24	19	in	in	ADP
gra-2159	24	20	the	the	DET
gra-2159	24	21	s1	s1	NOUN
gra-2159	24	22	and	and	CCONJ
gra-2159	24	23	s2	s2	NOUN
gra-2159	24	24	segments	segment	NOUN
gra-2159	24	25	of	of	ADP
gra-2159	24	26	the	the	DET
gra-2159	24	27	proximal	proximal	ADJ
gra-2159	24	28	tubule	tubule	NOUN
gra-2159	24	29	.	.	PUNCT
gra-2159	25	1	sglt2	sglt2	PROPN
gra-2159	25	2	is	be	AUX
gra-2159	25	3	an	an	DET
gra-2159	25	4	efcient	efcient	ADJ
gra-2159	25	5	glucose	glucose	NOUN
gra-2159	25	6	transporter	transporter	NOUN
gra-2159	25	7	of	of	ADP
gra-2159	25	8	the	the	DET
gra-2159	25	9	atp	atp	NOUN
gra-2159	25	10	-	-	PUNCT
gra-2159	25	11	dependent	dependent	ADJ
gra-2159	25	12	system	system	NOUN
gra-2159	25	13	that	that	PRON
gra-2159	25	14	reabsorbs	reabsorb	VERB
gra-2159	25	15	glucose.3	glucose.3	ADV
gra-2159	25	16	interestingly	interestingly	ADV
gra-2159	25	17	,	,	PUNCT
gra-2159	25	18	sglt2	sglt2	ADJ
gra-2159	25	19	expression	expression	NOUN
gra-2159	25	20	in	in	ADP
gra-2159	25	21	the	the	DET
gra-2159	25	22	proximal	proximal	ADJ
gra-2159	25	23	tubule	tubule	NOUN
gra-2159	25	24	is	be	AUX
gra-2159	25	25	increased	increase	VERB
gra-2159	25	26	in	in	ADP
gra-2159	25	27	patients	patient	NOUN
gra-2159	25	28	with	with	ADP
gra-2159	25	29	type	type	NOUN
gra-2159	25	30	2	2	NUM
gra-2159	25	31	diabetes	diabetes	NOUN
gra-2159	25	32	,	,	PUNCT
gra-2159	25	33	resulting	result	VERB
gra-2159	25	34	in	in	ADP
gra-2159	25	35	increases	increase	NOUN
gra-2159	25	36	in	in	ADP
gra-2159	25	37	glucose	glucose	NOUN
gra-2159	25	38	uptake	uptake	ADJ
gra-2159	25	39	exacerbating	exacerbate	VERB
gra-2159	25	40	hyperglycemia.4	hyperglycemia.4	NOUN
gra-2159	25	41	sglt2	sglt2	ADJ
gra-2159	25	42	inhibition	inhibition	NOUN
gra-2159	25	43	can	can	AUX
gra-2159	25	44	block	block	VERB
gra-2159	25	45	glucose	glucose	NOUN
gra-2159	25	46	and	and	CCONJ
gra-2159	25	47	sodium	sodium	NOUN
gra-2159	25	48	reabsorption	reabsorption	NOUN
gra-2159	25	49	at	at	ADP
gra-2159	25	50	the	the	DET
gra-2159	25	51	proximal	proximal	ADJ
gra-2159	25	52	tubule	tubule	NOUN
gra-2159	25	53	.	.	PUNCT
gra-2159	26	1	therefore	therefore	ADV
gra-2159	26	2	,	,	PUNCT
gra-2159	26	3	the	the	DET
gra-2159	26	4	administration	administration	NOUN
gra-2159	26	5	of	of	ADP
gra-2159	26	6	sglt2	sglt2	ADJ
gra-2159	26	7	inhibitors	inhibitor	NOUN
gra-2159	26	8	can	can	AUX
gra-2159	26	9	excrete	excrete	VERB
gra-2159	26	10	80–100	80–100	NUM
gra-2159	26	11	g	g	NOUN
gra-2159	26	12	/	/	SYM
gra-2159	26	13	day	day	NOUN
gra-2159	26	14	glucose	glucose	NOUN
gra-2159	26	15	in	in	ADP
gra-2159	26	16	the	the	DET
gra-2159	26	17	urine	urine	NOUN
gra-2159	26	18	,	,	PUNCT
gra-2159	26	19	translating	translate	VERB
gra-2159	26	20	to	to	ADP
gra-2159	26	21	240–400	240–400	NUM
gra-2159	26	22	kcal	kcal	ADJ
gra-2159	26	23	/	/	SYM
gra-2159	26	24	day	day	NOUN
gra-2159	26	25	.	.	PUNCT
gra-2159	27	1	they	they	PRON
gra-2159	27	2	have	have	AUX
gra-2159	27	3	been	be	AUX
gra-2159	27	4	proven	prove	VERB
gra-2159	27	5	to	to	PART
gra-2159	27	6	decrease	decrease	VERB
gra-2159	27	7	glycated	glycate	VERB
gra-2159	27	8	hemoglobin	hemoglobin	NOUN
gra-2159	27	9	(	(	PUNCT
gra-2159	27	10	hba1c	hba1c	PROPN
gra-2159	27	11	)	)	PUNCT
gra-2159	27	12	by	by	ADP
gra-2159	27	13	0.7–1.0	0.7–1.0	NOUN
gra-2159	27	14	%	%	NOUN
gra-2159	27	15	without	without	ADP
gra-2159	27	16	severe	severe	ADJ
gra-2159	27	17	hypoglycemia	hypoglycemia	NOUN
gra-2159	27	18	and	and	CCONJ
gra-2159	27	19	to	to	PART
gra-2159	27	20	reduce	reduce	VERB
gra-2159	27	21	body	body	NOUN
gra-2159	27	22	weight	weight	NOUN
gra-2159	27	23	by	by	ADP
gra-2159	27	24	3–4	3–4	NUM
gra-2159	27	25	kg	kg	NOUN
gra-2159	27	26	.	.	PUNCT
gra-2159	28	1	empagliozin	empagliozin	PROPN
gra-2159	28	2	is	be	AUX
gra-2159	28	3	a	a	DET
gra-2159	28	4	potent	potent	ADJ
gra-2159	28	5	and	and	CCONJ
gra-2159	28	6	selective	selective	ADJ
gra-2159	28	7	sglt2	sglt2	ADJ
gra-2159	28	8	inhibitor	inhibitor	NOUN
gra-2159	28	9	.	.	PUNCT
gra-2159	29	1	the	the	DET
gra-2159	29	2	empagliozin	empagliozin	PROPN
gra-2159	29	3	and	and	CCONJ
gra-2159	29	4	progression	progression	NOUN
gra-2159	29	5	of	of	ADP
gra-2159	29	6	kidney	kidney	NOUN
gra-2159	29	7	disease	disease	NOUN
gra-2159	29	8	in	in	ADP
gra-2159	29	9	type	type	NOUN
gra-2159	29	10	2	2	NUM
gra-2159	29	11	diabetes	diabetes	NOUN
gra-2159	29	12	(	(	PUNCT
gra-2159	29	13	empa	empa	NOUN
gra-2159	29	14	-	-	PUNCT
gra-2159	29	15	reg	reg	NOUN
gra-2159	29	16	renal	renal	ADJ
gra-2159	29	17	outcome	outcome	NOUN
gra-2159	29	18	)	)	PUNCT
gra-2159	29	19	trial	trial	NOUN
gra-2159	29	20	and	and	CCONJ
gra-2159	29	21	the	the	DET
gra-2159	29	22	canagliozin	canagliozin	PROPN
gra-2159	29	23	cardiovascular	cardiovascular	ADJ
gra-2159	29	24	assessment	assessment	NOUN
gra-2159	29	25	study	study	NOUN
gra-2159	29	26	program	program	NOUN
gra-2159	29	27	clearly	clearly	ADV
gra-2159	29	28	showed	show	VERB
gra-2159	29	29	the	the	DET
gra-2159	29	30	protective	protective	ADJ
gra-2159	29	31	effects	effect	NOUN
gra-2159	29	32	of	of	ADP
gra-2159	29	33	sglt2	sglt2	ADJ
gra-2159	29	34	inhibitors	inhibitor	NOUN
gra-2159	29	35	on	on	ADP
gra-2159	29	36	renal	renal	ADJ
gra-2159	29	37	outcomes	outcome	NOUN
gra-2159	29	38	in	in	ADP
gra-2159	29	39	patients	patient	NOUN
gra-2159	29	40	with	with	ADP
gra-2159	29	41	type	type	NOUN
gra-2159	29	42	2	2	NUM
gra-2159	29	43	diabetes	diabete	NOUN
gra-2159	29	44	,	,	PUNCT
gra-2159	29	45	including	include	VERB
gra-2159	29	46	decreases	decrease	NOUN
gra-2159	29	47	in	in	ADP
gra-2159	29	48	albuminuria	albuminuria	NOUN
gra-2159	29	49	and	and	CCONJ
gra-2159	29	50	progression	progression	NOUN
gra-2159	29	51	of	of	ADP
gra-2159	29	52	nephropathy	nephropathy	NOUN
gra-2159	29	53	,	,	PUNCT
gra-2159	29	54	doubling	double	VERB
gra-2159	29	55	of	of	ADP
gra-2159	29	56	serum	serum	NOUN
gra-2159	29	57	creatinine	creatinine	NOUN
gra-2159	29	58	levels	level	NOUN
gra-2159	29	59	,	,	PUNCT
gra-2159	29	60	and	and	CCONJ
gra-2159	29	61	initiation	initiation	NOUN
gra-2159	29	62	of	of	ADP
gra-2159	29	63	renal	renal	ADJ
gra-2159	29	64	1replacement	1replacement	NUM
gra-2159	29	65	therapy	therapy	NOUN
gra-2159	29	66	.	.	PUNCT
gra-2159	30	1	the	the	DET
gra-2159	30	2	potential	potential	ADJ
gra-2159	30	3	mechanism	mechanism	NOUN
gra-2159	30	4	of	of	ADP
gra-2159	30	5	the	the	DET
gra-2159	30	6	benecial	benecial	ADJ
gra-2159	30	7	effects	effect	NOUN
gra-2159	30	8	of	of	ADP
gra-2159	30	9	sglt2	sglt2	ADJ
gra-2159	30	10	inhibitors	inhibitor	NOUN
gra-2159	30	11	may	may	AUX
gra-2159	30	12	be	be	AUX
gra-2159	30	13	through	through	ADP
gra-2159	30	14	decre	decre	NOUN
gra-2159	30	15	asing	asing	PROPN
gra-2159	30	16	hyperltration	hyperltration	NOUN
gra-2159	30	17	.	.	PUNCT
gra-2159	31	1	by	by	ADP
gra-2159	31	2	reducing	reduce	VERB
gra-2159	31	3	proximal	proximal	ADJ
gra-2159	31	4	reabsorption	reabsorption	NOUN
gra-2159	31	5	of	of	ADP
gra-2159	31	6	sodium	sodium	NOUN
gra-2159	31	7	,	,	PUNCT
gra-2159	31	8	distal	distal	ADJ
gra-2159	31	9	sodium	sodium	NOUN
gra-2159	31	10	delivery	delivery	NOUN
gra-2159	31	11	is	be	AUX
gra-2159	31	12	increased	increase	VERB
gra-2159	31	13	,	,	PUNCT
gra-2159	31	14	activating	activate	VERB
gra-2159	31	15	tubular	tubular	ADJ
gra-2159	31	16	glomerular	glomerular	ADJ
gra-2159	31	17	feedback	feedback	NOUN
gra-2159	31	18	leading	lead	VERB
gra-2159	31	19	to	to	ADP
gra-2159	31	20	afferent	afferent	ADJ
gra-2159	31	21	arteriolar	arteriolar	ADJ
gra-2159	31	22	vasoconstriction	vasoconstriction	NOUN
gra-2159	31	23	and	and	CCONJ
gra-2159	31	24	a	a	DET
gra-2159	31	25	reduction	reduction	NOUN
gra-2159	31	26	in	in	ADP
gra-2159	31	27	hyperltration	hyperltration	NOUN
gra-2159	31	28	.	.	PUNCT
gra-2159	32	1	this	this	PRON
gra-2159	32	2	is	be	AUX
gra-2159	32	3	a	a	DET
gra-2159	32	4	2class	2class	NUM
gra-2159	32	5	effect	effect	NOUN
gra-2159	32	6	and	and	CCONJ
gra-2159	32	7	is	be	AUX
gra-2159	32	8	reversible	reversible	ADJ
gra-2159	32	9	after	after	ADP
gra-2159	32	10	stopping	stop	VERB
gra-2159	32	11	the	the	DET
gra-2159	32	12	drug	drug	NOUN
gra-2159	32	13	.	.	PUNCT
gra-2159	33	1	renal	renal	ADJ
gra-2159	33	2	function	function	NOUN
gra-2159	33	3	should	should	AUX
gra-2159	33	4	be	be	AUX
gra-2159	33	5	regularly	regularly	ADV
gra-2159	33	6	monitored	monitor	VERB
gra-2159	33	7	in	in	ADP
gra-2159	33	8	patients	patient	NOUN
gra-2159	33	9	taking	take	VERB
gra-2159	33	10	sglt2	sglt2	ADJ
gra-2159	33	11	inhibitors	inhibitor	NOUN
gra-2159	33	12	.	.	PUNCT
gra-2159	34	1	inhibitors	inhibitor	NOUN
gra-2159	34	2	of	of	ADP
gra-2159	34	3	dpp-4	dpp-4	ADV
gra-2159	34	4	reduce	reduce	VERB
gra-2159	34	5	blood	blood	NOUN
gra-2159	34	6	glucose	glucose	NOUN
gra-2159	34	7	in	in	ADP
gra-2159	34	8	patients	patient	NOUN
gra-2159	34	9	with	with	ADP
gra-2159	34	10	type	type	NOUN
gra-2159	34	11	2	2	NUM
gra-2159	34	12	diabetes	diabetes	NOUN
gra-2159	34	13	by	by	ADP
gra-2159	34	14	preventing	prevent	VERB
gra-2159	34	15	degradation	degradation	NOUN
gra-2159	34	16	of	of	ADP
gra-2159	34	17	incretin	incretin	ADJ
gra-2159	34	18	peptides	peptide	NOUN
gra-2159	34	19	such	such	ADJ
gra-2159	34	20	as	as	ADP
gra-2159	34	21	glp-1	glp-1	NOUN
gra-2159	34	22	,	,	PUNCT
gra-2159	34	23	stimulating	stimulate	VERB
gra-2159	34	24	insulin	insulin	NOUN
gra-2159	34	25	release	release	NOUN
gra-2159	34	26	and	and	CCONJ
gra-2159	34	27	inhibiting	inhibit	VERB
gra-2159	34	28	glucagon	glucagon	NOUN
gra-2159	34	29	combination	combination	NOUN
gra-2159	34	30	of	of	ADP
gra-2159	34	31	empagliflozin	empagliflozin	PROPN
gra-2159	34	32	and	and	CCONJ
gra-2159	34	33	linagliptin	linagliptin	ADJ
gra-2159	34	34	:	:	PUNCT
gra-2159	34	35	novel	novel	ADJ
gra-2159	34	36	agents	agent	NOUN
gra-2159	34	37	for	for	ADP
gra-2159	34	38	managing	manage	VERB
gra-2159	34	39	diabetic	diabetic	ADJ
gra-2159	34	40	kidney	kidney	NOUN
gra-2159	34	41	original	original	ADJ
gra-2159	34	42	research	research	NOUN
gra-2159	34	43	paper	paper	NOUN
gra-2159	34	44	samir	samir	PROPN
gra-2159	34	45	kanta	kanta	PROPN
gra-2159	34	46	datta	datta	PROPN
gra-2159	34	47	sp	sp	ADP
gra-2159	34	48	more	more	ADJ
gra-2159	34	49	,	,	PUNCT
gra-2159	34	50	suri	suri	PROPN
gra-2159	34	51	,	,	PUNCT
gra-2159	34	52	birbhum,731101	birbhum,731101	ADJ
gra-2159	34	53	medicine	medicine	NOUN
gra-2159	34	54	keywords	keyword	NOUN
gra-2159	34	55	:	:	PUNCT
gra-2159	34	56	volume-9	volume-9	NUM
gra-2159	34	57	,	,	PUNCT
gra-2159	34	58	issue-3	issue-3	NUM
gra-2159	34	59	,	,	PUNCT
gra-2159	34	60	march-2020	march-2020	ADJ
gra-2159	34	61	•	•	NOUN
gra-2159	34	62	print	print	NOUN
gra-2159	34	63	issn	issn	PROPN
gra-2159	34	64	no	no	NOUN
gra-2159	34	65	.	.	PROPN
gra-2159	34	66	2277	2277	NUM
gra-2159	34	67	8160	8160	NUM
gra-2159	34	68	•	•	NOUN
gra-2159	34	69	doi	doi	NOUN
gra-2159	34	70	:	:	PUNCT
gra-2159	34	71	10.36106	10.36106	NUM
gra-2159	34	72	/	/	SYM
gra-2159	34	73	gjra	gjra	PROPN
gra-2159	34	74	samir	samir	PROPN
gra-2159	34	75	kumar	kumar	PROPN
gra-2159	34	76	mishra	mishra	PROPN
gra-2159	34	77	*	*	PROPN
gra-2159	34	78	d/81,hig	d/81,hig	PROPN
gra-2159	34	79	,	,	PUNCT
gra-2159	34	80	baramunda	baramunda	PROPN
gra-2159	34	81	hb	hb	PROPN
gra-2159	34	82	colony	colony	NOUN
gra-2159	34	83	,	,	PUNCT
gra-2159	34	84	bhubaneswar	bhubaneswar	NOUN
gra-2159	34	85	751003	751003	NUM
gra-2159	34	86	*	*	PUNCT
gra-2159	34	87	corresponding	correspond	VERB
gra-2159	34	88	author	author	NOUN
gra-2159	34	89	sandeep	sandeep	PROPN
gra-2159	34	90	jain	jain	PROPN
gra-2159	34	91	doctors	doctors	PROPN
gra-2159	34	92	house	house	PROPN
gra-2159	34	93	near	near	ADP
gra-2159	34	94	pankaj	pankaj	PROPN
gra-2159	34	95	house	house	PROPN
gra-2159	34	96	chindwara-480001	chindwara-480001	PROPN
gra-2159	34	97	sandeep	sandeep	PROPN
gra-2159	34	98	desai	desai	PROPN
gra-2159	34	99	advance	advance	PROPN
gra-2159	34	100	diabetes	diabetes	NOUN
gra-2159	34	101	care	care	VERB
gra-2159	34	102	202	202	NUM
gra-2159	34	103	-	-	SYM
gra-2159	34	104	203	203	NUM
gra-2159	34	105	,	,	PUNCT
gra-2159	34	106	dreamland	dreamland	NOUN
gra-2159	34	107	arcade	arcade	NOUN
gra-2159	34	108	opp	opp	PROPN
gra-2159	34	109	jade	jade	PROPN
gra-2159	34	110	blue	blue	PROPN
gra-2159	34	111	,	,	PUNCT
gra-2159	34	112	tithal	tithal	NOUN
gra-2159	34	113	road	road	NOUN
gra-2159	34	114	valsad	valsad	NOUN
gra-2159	34	115	-396001	-396001	PROPN
gra-2159	34	116	sandeep	sandeep	PROPN
gra-2159	34	117	tiwari	tiwari	PROPN
gra-2159	34	118	raj	raj	PROPN
gra-2159	34	119	nursing	nursing	PROPN
gra-2159	34	120	home	home	NOUN
gra-2159	34	121	pehowa	pehowa	PROPN
gra-2159	34	122	city	city	NOUN
gra-2159	34	123	.136128	.136128	PROPN
gra-2159	34	124	44	44	NUM
gra-2159	34	125	x	x	SYM
gra-2159	34	126	gjra	gjra	PROPN
gra-2159	34	127	global	global	ADJ
gra-2159	34	128	journal	journal	PROPN
gra-2159	34	129	for	for	ADP
gra-2159	34	130	research	research	NOUN
gra-2159	34	131	analysis	analysis	NOUN
gra-2159	34	132	secretion	secretion	NOUN
gra-2159	34	133	.	.	PUNCT
gra-2159	35	1	briey	briey	ADJ
gra-2159	35	2	,	,	PUNCT
gra-2159	35	3	glucagon	glucagon	NOUN
gra-2159	35	4	-	-	PUNCT
gra-2159	35	5	like	like	ADJ
gra-2159	35	6	peptide	peptide	NOUN
gra-2159	35	7	1	1	NUM
gra-2159	35	8	(	(	PUNCT
gra-2159	35	9	glp-1	glp-1	NOUN
gra-2159	35	10	)	)	PUNCT
gra-2159	35	11	produced	produce	VERB
gra-2159	35	12	by	by	ADP
gra-2159	35	13	the	the	DET
gra-2159	35	14	l	l	NOUN
gra-2159	35	15	cells	cell	NOUN
gra-2159	35	16	in	in	ADP
gra-2159	35	17	the	the	DET
gra-2159	35	18	gut	gut	NOUN
gra-2159	35	19	stimulates	stimulate	VERB
gra-2159	35	20	the	the	DET
gra-2159	35	21	secretion	secretion	NOUN
gra-2159	35	22	of	of	ADP
gra-2159	35	23	insulin	insulin	NOUN
gra-2159	35	24	from	from	ADP
gra-2159	35	25	the	the	DET
gra-2159	35	26	pancreatic	pancreatic	ADJ
gra-2159	35	27	beta	beta	NOUN
gra-2159	35	28	cells	cell	NOUN
gra-2159	35	29	in	in	ADP
gra-2159	35	30	response	response	NOUN
gra-2159	35	31	to	to	ADP
gra-2159	35	32	a	a	DET
gra-2159	35	33	carbohydrate	carbohydrate	NOUN
gra-2159	35	34	-	-	PUNCT
gra-2159	35	35	rich	rich	ADJ
gra-2159	35	36	meal	meal	NOUN
gra-2159	35	37	,	,	PUNCT
gra-2159	35	38	slows	slow	VERB
gra-2159	35	39	gastric	gastric	ADJ
gra-2159	35	40	emptying	empty	VERB
gra-2159	35	41	inducing	induce	VERB
gra-2159	35	42	satiety	satiety	NOUN
gra-2159	35	43	,	,	PUNCT
gra-2159	35	44	and	and	CCONJ
gra-2159	35	45	reduces	reduce	VERB
gra-2159	35	46	the	the	DET
gra-2159	35	47	endogenous	endogenous	ADJ
gra-2159	35	48	production	production	NOUN
gra-2159	35	49	of	of	ADP
gra-2159	35	50	glucagon	glucagon	NOUN
gra-2159	35	51	during	during	ADP
gra-2159	35	52	fasting	fast	VERB
gra-2159	35	53	states	state	NOUN
gra-2159	35	54	,	,	PUNCT
gra-2159	35	55	therefore	therefore	ADV
gra-2159	35	56	improving	improve	VERB
gra-2159	35	57	postprandial	postprandial	ADJ
gra-2159	35	58	as	as	ADV
gra-2159	35	59	well	well	ADV
gra-2159	35	60	as	as	ADP
gra-2159	35	61	fasting	fast	VERB
gra-2159	35	62	glycemia	glycemia	NOUN
gra-2159	35	63	.	.	PUNCT
gra-2159	36	1	the	the	DET
gra-2159	36	2	half	half	ADJ
gra-2159	36	3	-	-	PUNCT
gra-2159	36	4	life	life	NOUN
gra-2159	36	5	of	of	ADP
gra-2159	36	6	glp-1	glp-1	NOUN
gra-2159	36	7	is	be	AUX
gra-2159	36	8	extremely	extremely	ADV
gra-2159	36	9	short	short	ADJ
gra-2159	36	10	as	as	SCONJ
gra-2159	36	11	it	it	PRON
gra-2159	36	12	is	be	AUX
gra-2159	36	13	cleaved	cleave	VERB
gra-2159	36	14	by	by	ADP
gra-2159	36	15	the	the	DET
gra-2159	36	16	dipeptidyl	dipeptidyl	ADJ
gra-2159	36	17	peptidase	peptidase	NOUN
gra-2159	36	18	4	4	NUM
gra-2159	36	19	(	(	PUNCT
gra-2159	36	20	dpp-4	dpp-4	NUM
gra-2159	36	21	)	)	PUNCT
gra-2159	36	22	.	.	PUNCT
gra-2159	37	1	the	the	DET
gra-2159	37	2	activity	activity	NOUN
gra-2159	37	3	of	of	ADP
gra-2159	37	4	dpp-4	dpp-4	NUM
gra-2159	37	5	is	be	AUX
gra-2159	37	6	increased	increase	VERB
gra-2159	37	7	in	in	ADP
gra-2159	37	8	obese	obese	ADJ
gra-2159	37	9	individuals	individual	NOUN
gra-2159	37	10	and	and	CCONJ
gra-2159	37	11	those	those	PRON
gra-2159	37	12	with	with	ADP
gra-2159	37	13	diabetes	diabetes	NOUN
gra-2159	37	14	,	,	PUNCT
gra-2159	37	15	therefore	therefore	ADV
gra-2159	37	16	reducing	reduce	VERB
gra-2159	37	17	the	the	DET
gra-2159	37	18	availability	availability	NOUN
gra-2159	37	19	of	of	ADP
gra-2159	37	20	glp-1	glp-1	NOUN
gra-2159	37	21	.	.	PUNCT
gra-2159	38	1	treatment	treatment	NOUN
gra-2159	38	2	with	with	ADP
gra-2159	38	3	dpp-4	dpp-4	ADJ
gra-2159	38	4	inhibitors	inhibitor	NOUN
gra-2159	38	5	improves	improve	VERB
gra-2159	38	6	glycemic	glycemic	ADJ
gra-2159	38	7	control	control	NOUN
gra-2159	38	8	by	by	ADP
gra-2159	38	9	restoring	restore	VERB
gra-2159	38	10	the	the	DET
gra-2159	38	11	5physiologic	5physiologic	NUM
gra-2159	38	12	levels	level	NOUN
gra-2159	38	13	of	of	ADP
gra-2159	38	14	glp-1	glp-1	NOUN
gra-2159	38	15	.	.	PUNCT
gra-2159	39	1	as	as	SCONJ
gra-2159	39	2	dpp-4	dpp-4	ADJ
gra-2159	39	3	inhibition	inhibition	NOUN
gra-2159	39	4	leads	lead	VERB
gra-2159	39	5	to	to	ADP
gra-2159	39	6	a	a	DET
gra-2159	39	7	glucose	glucose	NOUN
gra-2159	39	8	-	-	PUNCT
gra-2159	39	9	dependent	dependent	ADJ
gra-2159	39	10	release	release	NOUN
gra-2159	39	11	of	of	ADP
gra-2159	39	12	insulin	insulin	NOUN
gra-2159	39	13	,	,	PUNCT
gra-2159	39	14	it	it	PRON
gra-2159	39	15	is	be	AUX
gra-2159	39	16	associated	associate	VERB
gra-2159	39	17	with	with	ADP
gra-2159	39	18	a	a	DET
gra-2159	39	19	low	low	ADJ
gra-2159	39	20	risk	risk	NOUN
gra-2159	39	21	of	of	ADP
gra-2159	39	22	hypoglycemia	hypoglycemia	NOUN
gra-2159	39	23	.	.	PUNCT
gra-2159	40	1	linagliptin	linagliptin	PROPN
gra-2159	40	2	is	be	AUX
gra-2159	40	3	a	a	DET
gra-2159	40	4	potent	potent	ADJ
gra-2159	40	5	and	and	CCONJ
gra-2159	40	6	selective	selective	ADJ
gra-2159	40	7	6dpp-4	6dpp-4	NUM
gra-2159	40	8	inhibitor	inhibitor	NOUN
gra-2159	40	9	.	.	PUNCT
gra-2159	41	1	pooled	pool	VERB
gra-2159	41	2	data	datum	NOUN
gra-2159	41	3	from	from	ADP
gra-2159	41	4	13	13	NUM
gra-2159	41	5	phases	phase	NOUN
gra-2159	41	6	2	2	NUM
gra-2159	41	7	or	or	CCONJ
gra-2159	41	8	3	3	NUM
gra-2159	41	9	trials	trial	NOUN
gra-2159	41	10	of	of	ADP
gra-2159	41	11	the	the	DET
gra-2159	41	12	dpp-4	dpp-4	ADJ
gra-2159	41	13	,	,	PUNCT
gra-2159	41	14	linagliptin	linagliptin	ADJ
gra-2159	41	15	in	in	ADP
gra-2159	41	16	type	type	NOUN
gra-2159	41	17	2	2	NUM
gra-2159	41	18	diabetics	diabetic	NOUN
gra-2159	41	19	showed	show	VERB
gra-2159	41	20	intervention	intervention	NOUN
gra-2159	41	21	reduced	reduce	VERB
gra-2159	41	22	the	the	DET
gra-2159	41	23	risk	risk	NOUN
gra-2159	41	24	of	of	ADP
gra-2159	41	25	kidney	kidney	NOUN
gra-2159	41	26	disease	disease	NOUN
gra-2159	41	27	events	event	NOUN
gra-2159	41	28	by	by	ADP
gra-2159	41	29	16	16	NUM
gra-2159	41	30	%	%	NOUN
gra-2159	41	31	compared	compare	VERB
gra-2159	41	32	to	to	ADP
gra-2159	41	33	placebo	placebo	NOUN
gra-2159	41	34	.	.	PUNCT
gra-2159	42	1	empagliozin	empagliozin	PROPN
gra-2159	42	2	and	and	CCONJ
gra-2159	42	3	linagliptin	linagliptin	PROPN
gra-2159	42	4	have	have	VERB
gra-2159	42	5	complementary	complementary	ADJ
gra-2159	42	6	mecha	mecha	NOUN
gra-2159	42	7	nisms	nism	NOUN
gra-2159	42	8	of	of	ADP
gra-2159	42	9	action	action	NOUN
gra-2159	42	10	to	to	PART
gra-2159	42	11	maintain	maintain	VERB
gra-2159	42	12	glucose	glucose	NOUN
gra-2159	42	13	homeostasis	homeostasis	NOUN
gra-2159	42	14	in	in	ADP
gra-2159	42	15	patients	patient	NOUN
gra-2159	42	16	with	with	ADP
gra-2159	42	17	type	type	NOUN
gra-2159	42	18	2	2	NUM
gra-2159	42	19	diabetes	diabetes	NOUN
gra-2159	42	20	.	.	PUNCT
gra-2159	43	1	empagliozin	empagliozin	PROPN
gra-2159	43	2	lowers	lower	VERB
gra-2159	43	3	glucose	glucose	NOUN
gra-2159	43	4	through	through	ADP
gra-2159	43	5	the	the	DET
gra-2159	43	6	urine	urine	NOUN
gra-2159	43	7	by	by	ADP
gra-2159	43	8	blocking	block	VERB
gra-2159	43	9	glucose	glucose	NOUN
gra-2159	43	10	reabsorption	reabsorption	NOUN
gra-2159	43	11	in	in	ADP
gra-2159	43	12	the	the	DET
gra-2159	43	13	kidney	kidney	NOUN
gra-2159	43	14	.	.	PUNCT
gra-2159	44	1	the	the	DET
gra-2159	44	2	previous	previous	ADJ
gra-2159	44	3	study	study	NOUN
gra-2159	44	4	showed	show	VERB
gra-2159	44	5	that	that	SCONJ
gra-2159	44	6	sglt2i	sglt2i	PROPN
gra-2159	44	7	treatment	treatment	NOUN
gra-2159	44	8	would	would	AUX
gra-2159	44	9	increase	increase	VERB
gra-2159	44	10	endogenous	endogenous	ADJ
gra-2159	44	11	glucose	glucose	NOUN
gra-2159	44	12	production	production	NOUN
gra-2159	44	13	.	.	PUNCT
gra-2159	45	1	similarly	similarly	ADV
gra-2159	45	2	,	,	PUNCT
gra-2159	45	3	in	in	ADP
gra-2159	45	4	addition	addition	NOUN
gra-2159	45	5	to	to	ADP
gra-2159	45	6	lowering	lower	VERB
gra-2159	45	7	fpg	fpg	NOUN
gra-2159	45	8	and	and	CCONJ
gra-2159	45	9	post	post	ADJ
gra-2159	45	10	-	-	ADJ
gra-2159	45	11	challenge	challenge	ADJ
gra-2159	45	12	plasma	plasma	NOUN
gra-2159	45	13	glucose	glucose	NOUN
gra-2159	45	14	(	(	PUNCT
gra-2159	45	15	ppg	ppg	NOUN
gra-2159	45	16	)	)	PUNCT
gra-2159	45	17	,	,	PUNCT
gra-2159	45	18	empagliozin	empagliozin	PROPN
gra-2159	45	19	would	would	AUX
gra-2159	45	20	also	also	ADV
gra-2159	45	21	induce	induce	VERB
gra-2159	45	22	a	a	DET
gra-2159	45	23	compensatory	compensatory	ADJ
gra-2159	45	24	increase	increase	NOUN
gra-2159	45	25	in	in	ADP
gra-2159	45	26	endogenous	endogenous	ADJ
gra-2159	45	27	glucose	glucose	NOUN
gra-2159	45	28	production	production	NOUN
gra-2159	45	29	.	.	PUNCT
gra-2159	46	1	glucagon	glucagon	NOUN
gra-2159	46	2	increase	increase	NOUN
gra-2159	46	3	would	would	AUX
gra-2159	46	4	switch	switch	VERB
gra-2159	46	5	back	back	ADV
gra-2159	46	6	after	after	ADP
gra-2159	46	7	4weeks	4weeks	NUM
gra-2159	46	8	of	of	ADP
gra-2159	46	9	treatment	treatment	NOUN
gra-2159	46	10	.	.	PUNCT
gra-2159	47	1	linagliptin	linagliptin	PROPN
gra-2159	47	2	,	,	PUNCT
gra-2159	47	3	a	a	DET
gra-2159	47	4	dpp-4i	dpp-4i	VERB
gra-2159	47	5	,	,	PUNCT
gra-2159	47	6	probably	probably	ADV
gra-2159	47	7	has	have	VERB
gra-2159	47	8	the	the	DET
gra-2159	47	9	potential	potential	NOUN
gra-2159	47	10	of	of	ADP
gra-2159	47	11	inhibiting	inhibit	VERB
gra-2159	47	12	the	the	DET
gra-2159	47	13	increase	increase	NOUN
gra-2159	47	14	in	in	ADP
gra-2159	47	15	endogenous	endogenous	ADJ
gra-2159	47	16	glucose	glucose	NOUN
gra-2159	47	17	production	production	NOUN
gra-2159	47	18	and	and	CCONJ
gra-2159	47	19	then	then	ADV
gra-2159	47	20	improve	improve	VERB
gra-2159	47	21	the	the	DET
gra-2159	47	22	glucose	glucose	NOUN
gra-2159	47	23	-	-	PUNCT
gra-2159	47	24	lowering	lower	VERB
gra-2159	47	25	activity	activity	NOUN
gra-2159	47	26	of	of	ADP
gra-2159	47	27	empagliozin	empagliozin	PROPN
gra-2159	47	28	.	.	PUNCT
gra-2159	48	1	in	in	ADP
gra-2159	48	2	addition	addition	NOUN
gra-2159	48	3	,	,	PUNCT
gra-2159	48	4	this	this	DET
gra-2159	48	5	combination	combination	NOUN
gra-2159	48	6	has	have	AUX
gra-2159	48	7	been	be	AUX
gra-2159	48	8	proved	prove	VERB
gra-2159	48	9	benecial	benecial	ADJ
gra-2159	48	10	to	to	PART
gra-2159	48	11	improve	improve	VERB
gra-2159	48	12	ß	ß	DET
gra-2159	48	13	cell	cell	NOUN
gra-2159	48	14	functions	function	NOUN
gra-2159	48	15	and	and	CCONJ
gra-2159	48	16	insulin	insulin	NOUN
gra-2159	48	17	sensitivity	sensitivity	NOUN
gra-2159	48	18	.	.	PUNCT
gra-2159	49	1	the	the	DET
gra-2159	49	2	american	american	ADJ
gra-2159	49	3	diabetes	diabetes	PROPN
gra-2159	49	4	association	association	NOUN
gra-2159	49	5	recommends	recommend	VERB
gra-2159	49	6	a	a	DET
gra-2159	49	7	glycemic	glycemic	ADJ
gra-2159	49	8	target	target	NOUN
gra-2159	49	9	of	of	ADP
gra-2159	49	10	glycosylated	glycosylated	ADJ
gra-2159	49	11	hemoglobin	hemoglobin	NOUN
gra-2159	49	12	(	(	PUNCT
gra-2159	49	13	hba1c	hba1c	PROPN
gra-2159	49	14	)	)	PUNCT
gra-2159	49	15	<	<	X
gra-2159	49	16	7	7	NUM
gra-2159	49	17	%	%	NOUN
gra-2159	49	18	.	.	PUNCT
gra-2159	50	1	the	the	DET
gra-2159	50	2	clinical	clinical	ADJ
gra-2159	50	3	trial	trial	NOUN
gra-2159	50	4	combined	combine	VERB
gra-2159	50	5	empagliozin	empagliozin	PROPN
gra-2159	50	6	with	with	ADP
gra-2159	50	7	linagliptin	linagliptin	PROPN
gra-2159	50	8	showed	show	VERB
gra-2159	50	9	that	that	SCONJ
gra-2159	50	10	the	the	DET
gra-2159	50	11	number	number	NOUN
gra-2159	50	12	of	of	ADP
gra-2159	50	13	patients	patient	NOUN
gra-2159	50	14	reaching	reach	VERB
gra-2159	50	15	hba1c	hba1c	NOUN
gra-2159	50	16	<	<	X
gra-2159	50	17	7	7	NUM
gra-2159	50	18	%	%	NOUN
gra-2159	50	19	exceeded	exceed	VERB
gra-2159	50	20	50	50	NUM
gra-2159	50	21	%	%	NOUN
gra-2159	50	22	.	.	PUNCT
gra-2159	51	1	in	in	ADP
gra-2159	51	2	addition	addition	NOUN
gra-2159	51	3	to	to	ADP
gra-2159	51	4	both	both	DET
gra-2159	51	5	empagliozin	empagliozin	PROPN
gra-2159	51	6	and	and	CCONJ
gra-2159	51	7	linagliptin	linagliptin	PROPN
gra-2159	51	8	being	be	AUX
gra-2159	51	9	highly	highly	ADV
gra-2159	51	10	effective	effective	ADJ
gra-2159	51	11	in	in	ADP
gra-2159	51	12	achieving	achieve	VERB
gra-2159	51	13	glucose	glucose	NOUN
gra-2159	51	14	homeostasis	homeostasis	NOUN
gra-2159	51	15	,	,	PUNCT
gra-2159	51	16	there	there	PRON
gra-2159	51	17	are	be	VERB
gra-2159	51	18	other	other	ADJ
gra-2159	51	19	reasons	reason	NOUN
gra-2159	51	20	for	for	ADP
gra-2159	51	21	considering	consider	VERB
gra-2159	51	22	the	the	DET
gra-2159	51	23	combination	combination	NOUN
gra-2159	51	24	.	.	PUNCT
gra-2159	52	1	cherney	cherney	NOUN
gra-2159	52	2	et	et	PROPN
gra-2159	52	3	al	al	PROPN
gra-2159	52	4	.	.	PROPN
gra-2159	52	5	found	find	VERB
gra-2159	52	6	that	that	SCONJ
gra-2159	52	7	empagliozin	empagliozin	PROPN
gra-2159	52	8	could	could	AUX
gra-2159	52	9	recede	recede	VERB
gra-2159	52	10	renal	renal	ADJ
gra-2159	52	11	hyperltration	hyperltration	NOUN
gra-2159	52	12	,	,	PUNCT
gra-2159	52	13	which	which	PRON
gra-2159	52	14	7represents	7represents	NUM
gra-2159	52	15	intra	intra	ADJ
gra-2159	52	16	-	-	ADJ
gra-2159	52	17	glomerular	glomerular	ADJ
gra-2159	52	18	pressure	pressure	NOUN
gra-2159	52	19	.	.	PUNCT
gra-2159	53	1	empagliozin	empagliozin	PROPN
gra-2159	53	2	consistently	consistently	ADV
gra-2159	53	3	contributed	contribute	VERB
gra-2159	53	4	to	to	ADP
gra-2159	53	5	the	the	DET
gra-2159	53	6	weight	weight	NOUN
gra-2159	53	7	loss	loss	NOUN
gra-2159	53	8	during	during	ADP
gra-2159	53	9	combining	combine	VERB
gra-2159	53	10	with	with	ADP
gra-2159	53	11	linagliptin	linagliptin	NOUN
gra-2159	53	12	.	.	PUNCT
gra-2159	54	1	the	the	DET
gra-2159	54	2	pharmacologic	pharmacologic	ADJ
gra-2159	54	3	actions	action	NOUN
gra-2159	54	4	of	of	ADP
gra-2159	54	5	empagliozin	empagliozin	PROPN
gra-2159	54	6	reducing	reduce	VERB
gra-2159	54	7	sbp	sbp	NOUN
gra-2159	54	8	contain	contain	VERB
gra-2159	54	9	weight	weight	NOUN
gra-2159	54	10	loss	loss	NOUN
gra-2159	54	11	,	,	PUNCT
gra-2159	54	12	osmotic	osmotic	ADJ
gra-2159	54	13	diuresis	diuresis	NOUN
gra-2159	54	14	,	,	PUNCT
gra-2159	54	15	reduced	reduce	VERB
gra-2159	54	16	arterial	arterial	ADJ
gra-2159	54	17	stiffness	stiffness	NOUN
gra-2159	54	18	,	,	PUNCT
gra-2159	54	19	and	and	CCONJ
gra-2159	54	20	direct	direct	ADJ
gra-2159	54	21	vascular	vascular	ADJ
gra-2159	54	22	effects	effect	NOUN
gra-2159	54	23	,	,	PUNCT
gra-2159	54	24	while	while	SCONJ
gra-2159	54	25	linagliptin	linagliptin	PROPN
gra-2159	54	26	glanced	glance	VERB
gra-2159	54	27	off	off	ADP
gra-2159	54	28	blood	blood	NOUN
gra-2159	54	29	pressure	pressure	NOUN
gra-2159	54	30	.	.	PUNCT
gra-2159	55	1	in	in	ADP
gra-2159	55	2	consequence	consequence	NOUN
gra-2159	55	3	,	,	PUNCT
gra-2159	55	4	combining	combine	VERB
gra-2159	55	5	empagliozin	empagliozin	PROPN
gra-2159	55	6	with	with	ADP
gra-2159	55	7	linagliptin	linagliptin	PROPN
gra-2159	55	8	has	have	VERB
gra-2159	55	9	a	a	DET
gra-2159	55	10	signicant	signicant	ADJ
gra-2159	55	11	advantage	advantage	NOUN
gra-2159	55	12	in	in	ADP
gra-2159	55	13	exerting	exert	VERB
gra-2159	55	14	hypoglycemic	hypoglycemic	ADJ
gra-2159	55	15	actions	action	NOUN
gra-2159	55	16	and	and	CCONJ
gra-2159	55	17	benecial	benecial	ADJ
gra-2159	55	18	effects	effect	NOUN
gra-2159	55	19	on	on	ADP
gra-2159	55	20	the	the	DET
gra-2159	55	21	8kidney	8kidney	NUM
gra-2159	55	22	,	,	PUNCT
gra-2159	55	23	body	body	NOUN
gra-2159	55	24	weight	weight	NOUN
gra-2159	55	25	,	,	PUNCT
gra-2159	55	26	and	and	CCONJ
gra-2159	55	27	sbp	sbp	NOUN
gra-2159	55	28	.	.	PUNCT
gra-2159	56	1	the	the	DET
gra-2159	56	2	potential	potential	ADJ
gra-2159	56	3	mechanism	mechanism	NOUN
gra-2159	56	4	of	of	ADP
gra-2159	56	5	the	the	DET
gra-2159	56	6	benecial	benecial	ADJ
gra-2159	56	7	effects	effect	NOUN
gra-2159	56	8	of	of	ADP
gra-2159	56	9	sglt2i	sglt2i	NOUN
gra-2159	56	10	is	be	AUX
gra-2159	56	11	believed	believe	VERB
gra-2159	56	12	to	to	PART
gra-2159	56	13	be	be	AUX
gra-2159	56	14	through	through	ADP
gra-2159	56	15	decreasing	decrease	VERB
gra-2159	56	16	hyperltration	hyperltration	NOUN
gra-2159	56	17	.	.	PUNCT
gra-2159	57	1	if	if	SCONJ
gra-2159	57	2	true	true	ADJ
gra-2159	57	3	,	,	PUNCT
gra-2159	57	4	then	then	ADV
gra-2159	57	5	these	these	DET
gra-2159	57	6	sglt2i	sglt2i	ADJ
gra-2159	57	7	drugs	drug	NOUN
gra-2159	57	8	may	may	AUX
gra-2159	57	9	also	also	ADV
gra-2159	57	10	be	be	AUX
gra-2159	57	11	effective	effective	ADJ
gra-2159	57	12	in	in	ADP
gra-2159	57	13	nondiabetic	nondiabetic	ADJ
gra-2159	57	14	kidney	kidney	NOUN
gra-2159	57	15	disease	disease	NOUN
gra-2159	57	16	,	,	PUNCT
gra-2159	57	17	a	a	DET
gra-2159	57	18	hypothesis	hypothesis	NOUN
gra-2159	57	19	that	that	PRON
gra-2159	57	20	is	be	AUX
gra-2159	57	21	being	be	AUX
gra-2159	57	22	tested	test	VERB
gra-2159	57	23	in	in	ADP
gra-2159	57	24	the	the	DET
gra-2159	57	25	study	study	NOUN
gra-2159	57	26	to	to	PART
gra-2159	57	27	evaluate	evaluate	VERB
gra-2159	57	28	the	the	DET
gra-2159	57	29	effect	effect	NOUN
gra-2159	57	30	of	of	ADP
gra-2159	57	31	dapagliozin	dapagliozin	PROPN
gra-2159	57	32	on	on	ADP
gra-2159	57	33	renal	renal	ADJ
gra-2159	57	34	outcomes	outcome	NOUN
gra-2159	57	35	and	and	CCONJ
gra-2159	57	36	cardiovascular	cardiovascular	ADJ
gra-2159	57	37	mortality	mortality	NOUN
gra-2159	57	38	in	in	ADP
gra-2159	57	39	patients	patient	NOUN
gra-2159	57	40	with	with	ADP
gra-2159	57	41	ckd	ckd	PROPN
gra-2159	57	42	(	(	PUNCT
gra-2159	57	43	dapa	dapa	PROPN
gra-2159	57	44	ckd	ckd	PROPN
gra-2159	57	45	)	)	PUNCT
gra-2159	57	46	in	in	ADP
gra-2159	57	47	which	which	PRON
gra-2159	57	48	half	half	NOUN
gra-2159	57	49	the	the	DET
gra-2159	57	50	patients	patient	NOUN
gra-2159	57	51	are	be	AUX
gra-2159	57	52	diabetic	diabetic	ADJ
gra-2159	57	53	and	and	CCONJ
gra-2159	57	54	half	half	NOUN
gra-2159	57	55	are	be	AUX
gra-2159	57	56	nondiabetic	nondiabetic	ADJ
gra-2159	57	57	.	.	PUNCT
gra-2159	58	1	the	the	DET
gra-2159	58	2	primary	primary	ADJ
gra-2159	58	3	outcome	outcome	NOUN
gra-2159	58	4	is	be	AUX
gra-2159	58	5	a	a	DET
gra-2159	58	6	composite	composite	NOUN
gra-2159	58	7	of	of	ADP
gra-2159	58	8	≥50	≥50	NUM
gra-2159	58	9	%	%	NOUN
gra-2159	58	10	sustained	sustained	ADJ
gra-2159	58	11	decline	decline	NOUN
gra-2159	58	12	in	in	ADP
gra-2159	58	13	egfr	egfr	PROPN
gra-2159	58	14	,	,	PUNCT
gra-2159	58	15	esrd	esrd	PROPN
gra-2159	58	16	,	,	PUNCT
gra-2159	58	17	or	or	CCONJ
gra-2159	58	18	cv	cv	PROPN
gra-2159	58	19	or	or	CCONJ
gra-2159	58	20	kidney	kidney	NOUN
gra-2159	58	21	death	death	NOUN
gra-2159	58	22	.	.	PUNCT
gra-2159	59	1	conclusion	conclusion	NOUN
gra-2159	59	2	slowing	slow	VERB
gra-2159	59	3	progression	progression	NOUN
gra-2159	59	4	of	of	ADP
gra-2159	59	5	kidney	kidney	NOUN
gra-2159	59	6	disease	disease	NOUN
gra-2159	59	7	is	be	AUX
gra-2159	59	8	a	a	DET
gra-2159	59	9	critical	critical	ADJ
gra-2159	59	10	goal	goal	NOUN
gra-2159	59	11	for	for	ADP
gra-2159	59	12	diabetic	diabetic	ADJ
gra-2159	59	13	kidney	kidney	NOUN
gra-2159	59	14	patients	patient	NOUN
gra-2159	59	15	.	.	PUNCT
gra-2159	60	1	thus	thus	ADV
gra-2159	60	2	,	,	PUNCT
gra-2159	60	3	the	the	DET
gra-2159	60	4	management	management	NOUN
gra-2159	60	5	of	of	ADP
gra-2159	60	6	renal	renal	ADJ
gra-2159	60	7	function	function	NOUN
gra-2159	60	8	in	in	ADP
gra-2159	60	9	diabetic	diabetic	ADJ
gra-2159	60	10	patients	patient	NOUN
gra-2159	60	11	is	be	AUX
gra-2159	60	12	critical	critical	ADJ
gra-2159	60	13	.	.	PUNCT
gra-2159	61	1	various	various	ADJ
gra-2159	61	2	big	big	ADJ
gra-2159	61	3	trials	trial	NOUN
gra-2159	61	4	have	have	AUX
gra-2159	61	5	established	establish	VERB
gra-2159	61	6	that	that	PRON
gra-2159	61	7	intensive	intensive	ADJ
gra-2159	61	8	glycemic	glycemic	ADJ
gra-2159	61	9	control	control	NOUN
gra-2159	61	10	might	might	AUX
gra-2159	61	11	inhibit	inhibit	VERB
gra-2159	61	12	the	the	DET
gra-2159	61	13	progression	progression	NOUN
gra-2159	61	14	of	of	ADP
gra-2159	61	15	dkd	dkd	PROPN
gra-2159	61	16	.	.	PUNCT
gra-2159	62	1	thus	thus	ADV
gra-2159	62	2	,	,	PUNCT
gra-2159	62	3	hyperglycemia	hyperglycemia	NOUN
gra-2159	62	4	could	could	AUX
gra-2159	62	5	be	be	AUX
gra-2159	62	6	a	a	DET
gra-2159	62	7	major	major	ADJ
gra-2159	62	8	factor	factor	NOUN
gra-2159	62	9	in	in	ADP
gra-2159	62	10	the	the	DET
gra-2159	62	11	progression	progression	NOUN
gra-2159	62	12	of	of	ADP
gra-2159	62	13	dkd	dkd	PROPN
gra-2159	62	14	.	.	PUNCT
gra-2159	63	1	however	however	ADV
gra-2159	63	2	,	,	PUNCT
gra-2159	63	3	dkd	dkd	PROPN
gra-2159	63	4	develops	develop	VERB
gra-2159	63	5	despite	despite	SCONJ
gra-2159	63	6	good	good	ADJ
gra-2159	63	7	glycemic	glycemic	ADJ
gra-2159	63	8	control	control	NOUN
gra-2159	63	9	.	.	PUNCT
gra-2159	64	1	thus	thus	ADV
gra-2159	64	2	,	,	PUNCT
gra-2159	64	3	novel	novel	ADJ
gra-2159	64	4	therapeutic	therapeutic	ADJ
gra-2159	64	5	agents	agent	NOUN
gra-2159	64	6	beyond	beyond	ADP
gra-2159	64	7	those	those	PRON
gra-2159	64	8	for	for	ADP
gra-2159	64	9	glycemic	glycemic	ADJ
gra-2159	64	10	control	control	NOUN
gra-2159	64	11	in	in	ADP
gra-2159	64	12	patients	patient	NOUN
gra-2159	64	13	with	with	ADP
gra-2159	64	14	dkd	dkd	PROPN
gra-2159	64	15	are	be	AUX
gra-2159	64	16	the	the	DET
gra-2159	64	17	need	need	NOUN
gra-2159	64	18	of	of	ADP
gra-2159	64	19	the	the	DET
gra-2159	64	20	hour	hour	NOUN
gra-2159	64	21	.	.	PUNCT
gra-2159	65	1	a	a	DET
gra-2159	65	2	combination	combination	NOUN
gra-2159	65	3	of	of	ADP
gra-2159	65	4	empagliozin	empagliozin	PROPN
gra-2159	65	5	and	and	CCONJ
gra-2159	65	6	linagliptin	linagliptin	PROPN
gra-2159	65	7	is	be	AUX
gra-2159	65	8	one	one	NUM
gra-2159	65	9	such	such	ADJ
gra-2159	65	10	new	new	ADJ
gra-2159	65	11	therapeutic	therapeutic	ADJ
gra-2159	65	12	approach	approach	NOUN
gra-2159	65	13	for	for	ADP
gra-2159	65	14	the	the	DET
gra-2159	65	15	management	management	NOUN
gra-2159	65	16	of	of	ADP
gra-2159	65	17	dkd	dkd	PROPN
gra-2159	65	18	.	.	PUNCT
gra-2159	66	1	empagliozin	empagliozin	PROPN
gra-2159	66	2	is	be	AUX
gra-2159	66	3	a	a	DET
gra-2159	66	4	potent	potent	ADJ
gra-2159	66	5	and	and	CCONJ
gra-2159	66	6	selective	selective	ADJ
gra-2159	66	7	sglt2i	sglt2i	NOUN
gra-2159	66	8	while	while	SCONJ
gra-2159	66	9	,	,	PUNCT
gra-2159	66	10	linagliptin	linagliptin	PROPN
gra-2159	66	11	is	be	AUX
gra-2159	66	12	a	a	DET
gra-2159	66	13	potent	potent	ADJ
gra-2159	66	14	and	and	CCONJ
gra-2159	66	15	selective	selective	ADJ
gra-2159	66	16	dpp-4i	dpp-4i	PROPN
gra-2159	66	17	.	.	PUNCT
gra-2159	67	1	given	give	VERB
gra-2159	67	2	the	the	DET
gra-2159	67	3	complementary	complementary	ADJ
gra-2159	67	4	mechanisms	mechanism	NOUN
gra-2159	67	5	of	of	ADP
gra-2159	67	6	action	action	NOUN
gra-2159	67	7	of	of	ADP
gra-2159	67	8	empagliozin	empagliozin	PROPN
gra-2159	67	9	and	and	CCONJ
gra-2159	67	10	linagliptin	linagliptin	PROPN
gra-2159	67	11	,	,	PUNCT
gra-2159	67	12	the	the	DET
gra-2159	67	13	combination	combination	NOUN
gra-2159	67	14	is	be	AUX
gra-2159	67	15	expected	expect	VERB
gra-2159	67	16	to	to	PART
gra-2159	67	17	slow	slow	VERB
gra-2159	67	18	the	the	DET
gra-2159	67	19	progression	progression	NOUN
gra-2159	67	20	of	of	ADP
gra-2159	67	21	dkd	dkd	PROPN
gra-2159	67	22	.	.	PUNCT
gra-2159	68	1	few	few	ADJ
gra-2159	68	2	trials	trial	NOUN
gra-2159	68	3	have	have	AUX
gra-2159	68	4	shown	show	VERB
gra-2159	68	5	their	their	PRON
gra-2159	68	6	potential	potential	NOUN
gra-2159	68	7	as	as	ADP
gra-2159	68	8	a	a	DET
gra-2159	68	9	renoprotective	renoprotective	ADJ
gra-2159	68	10	combination	combination	NOUN
gra-2159	68	11	in	in	ADP
gra-2159	68	12	diabetic	diabetic	ADJ
gra-2159	68	13	patients	patient	NOUN
gra-2159	68	14	.	.	PUNCT
gra-2159	69	1	however	however	ADV
gra-2159	69	2	,	,	PUNCT
gra-2159	69	3	larger	large	ADJ
gra-2159	69	4	clinical	clinical	ADJ
gra-2159	69	5	trials	trial	NOUN
gra-2159	69	6	need	need	VERB
gra-2159	69	7	to	to	PART
gra-2159	69	8	be	be	AUX
gra-2159	69	9	undertaken	undertake	VERB
gra-2159	69	10	to	to	PART
gra-2159	69	11	establish	establish	VERB
gra-2159	69	12	their	their	PRON
gra-2159	69	13	efcacy	efcacy	NOUN
gra-2159	69	14	in	in	ADP
gra-2159	69	15	slowing	slow	VERB
gra-2159	69	16	the	the	DET
gra-2159	69	17	progression	progression	NOUN
gra-2159	69	18	of	of	ADP
gra-2159	69	19	dkd	dkd	PROPN
gra-2159	69	20	.	.	PUNCT
gra-2159	70	1	references	reference	NOUN
gra-2159	70	2	1	1	NUM
gra-2159	70	3	.	.	PUNCT
gra-2159	70	4	mima	mima	PROPN
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gra-2159	70	9	sodium	sodium	NOUN
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gra-2159	70	11	glucose	glucose	NOUN
gra-2159	70	12	cotransporter	cotransporter	NOUN
gra-2159	70	13	2	2	NUM
gra-2159	70	14	inhibitors	inhibitor	NOUN
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gra-2159	70	16	its	its	PRON
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gra-2159	70	22	disease	disease	NOUN
gra-2159	70	23	.	.	PUNCT
gra-2159	71	1	j	j	PROPN
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gra-2159	72	2	-	-	SYM
gra-2159	72	3	725	725	NUM
gra-2159	72	4	.	.	PUNCT
gra-2159	72	5	doi:10.1016	doi:10.1016	PROPN
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gra-2159	72	9	.	.	PUNCT
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gra-2159	72	12	,	,	PUNCT
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gra-2159	72	16	rosenberg	rosenberg	PROPN
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gra-2159	72	18	.	.	PUNCT
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gra-2159	73	4	chronic	chronic	ADJ
gra-2159	73	5	kidney	kidney	NOUN
gra-2159	73	6	disease	disease	NOUN
gra-2159	73	7	.	.	PUNCT
gra-2159	74	1	elsevier	elsevier	PROPN
gra-2159	74	2	inc	inc	PROPN
gra-2159	74	3	.	.	PROPN
gra-2159	74	4	;	;	PUNCT
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gra-2159	74	6	.	.	PUNCT
gra-2159	75	1	doi:10.1016	doi:10.1016	PROPN
gra-2159	75	2	/	/	SYM
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gra-2159	75	5	0	0	NUM
gra-2159	75	6	-	-	PUNCT
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gra-2159	75	8	-	-	PUNCT
gra-2159	75	9	815876	815876	NUM
gra-2159	75	10	-	-	PUNCT
gra-2159	75	11	0.00057	0.00057	NUM
gra-2159	75	12	-	-	PUNCT
gra-2159	75	13	7	7	NUM
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gra-2159	75	15	.	.	PUNCT
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gra-2159	76	9	patients	patient	NOUN
gra-2159	76	10	with	with	ADP
gra-2159	76	11	chronic	chronic	ADJ
gra-2159	76	12	kidney	kidney	NOUN
gra-2159	76	13	disease	disease	NOUN
gra-2159	76	14	:	:	PUNCT
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gra-2159	77	7	.	.	PUNCT
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gra-2159	78	2	:	:	PUNCT
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gra-2159	78	4	.	.	PUNCT
gra-2159	78	5	doi:10.1016	doi:10.1016	PROPN
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gra-2159	78	9	.	.	PUNCT
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gra-2159	78	14	and	and	CCONJ
gra-2159	78	15	macrovascular	macrovascular	ADJ
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gra-2159	78	19	.	.	PUNCT
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gra-2159	79	2	-	-	SYM
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gra-2159	79	4	.	.	NOUN
gra-2159	80	1	5	5	X
gra-2159	80	2	.	.	X
gra-2159	80	3	carbone	carbone	PROPN
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gra-2159	80	5	,	,	PUNCT
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gra-2159	80	8	,	,	PUNCT
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gra-2159	80	31	-	-	PUNCT
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gra-2159	80	33	-	-	PUNCT
gra-2159	80	34	art	art	NOUN
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gra-2159	81	4	.	.	PUNCT
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gra-2159	82	4	.	.	PUNCT
gra-2159	83	1	doi:10.1016	doi:10.1016	PROPN
gra-2159	83	2	/	/	SYM
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gra-2159	84	12	of	of	ADP
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gra-2159	84	14	-	-	PUNCT
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gra-2159	85	1	j	j	PROPN
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gra-2159	86	2	.	.	PUNCT
gra-2159	86	3	doi:10.1016	doi:10.1016	PROPN
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gra-2159	86	7	.	.	PUNCT
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gra-2159	86	16	et	et	PROPN
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gra-2159	86	18	.	.	PUNCT
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gra-2159	87	5	-	-	PUNCT
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gra-2159	87	8	2	2	NUM
gra-2159	87	9	inhibition	inhibition	NOUN
gra-2159	87	10	in	in	ADP
gra-2159	87	11	patients	patient	NOUN
gra-2159	87	12	with	with	ADP
gra-2159	87	13	type	type	NOUN
gra-2159	87	14	1	1	NUM
gra-2159	87	15	diabetesmellitus	diabetesmellitus	NOUN
gra-2159	87	16	.	.	PUNCT
gra-2159	88	1	circulation	circulation	NOUN
gra-2159	88	2	.	.	PUNCT
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gra-2159	89	2	.	.	NOUN
gra-2159	90	1	8	8	X
gra-2159	90	2	.	.	X
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gra-2159	91	2	.	.	PUNCT
gra-2159	92	1	doi:10.1016	doi:10.1016	PROPN
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