id	sid	tid	token	lemma	pos
gra-901	1	1	introduction	introduction	NOUN
gra-901	1	2	:	:	PUNCT
gra-901	1	3	the	the	DET
gra-901	1	4	unfolded	unfolded	ADJ
gra-901	1	5	protein	protein	NOUN
gra-901	1	6	response	response	NOUN
gra-901	1	7	(	(	PUNCT
gra-901	1	8	upr	upr	NOUN
gra-901	1	9	)	)	PUNCT
gra-901	1	10	is	be	AUX
gra-901	1	11	a	a	DET
gra-901	1	12	cellular	cellular	ADJ
gra-901	1	13	stress	stress	NOUN
gra-901	1	14	response	response	NOUN
gra-901	1	15	related	relate	VERB
gra-901	1	16	to	to	ADP
gra-901	1	17	the	the	DET
gra-901	1	18	endoplasmic	endoplasmic	ADJ
gra-901	1	19	reticulum	reticulum	NOUN
gra-901	1	20	(	(	PUNCT
gra-901	1	21	er	er	INTJ
gra-901	1	22	)	)	PUNCT
gra-901	1	23	stress	stress	NOUN
gra-901	1	24	.	.	PUNCT
gra-901	2	1	the	the	DET
gra-901	2	2	upr	upr	NOUN
gra-901	2	3	is	be	AUX
gra-901	2	4	activated	activate	VERB
gra-901	2	5	in	in	ADP
gra-901	2	6	response	response	NOUN
gra-901	2	7	to	to	ADP
gra-901	2	8	an	an	DET
gra-901	2	9	accumulation	accumulation	NOUN
gra-901	2	10	of	of	ADP
gra-901	2	11	unfolded	unfolded	ADJ
gra-901	2	12	or	or	CCONJ
gra-901	2	13	misfolded	misfolde	VERB
gra-901	2	14	proteins	protein	NOUN
gra-901	2	15	in	in	ADP
gra-901	2	16	the	the	DET
gra-901	2	17	lumen	luman	NOUN
gra-901	2	18	of	of	ADP
gra-901	2	19	the	the	DET
gra-901	2	20	endoplasmic	endoplasmic	ADJ
gra-901	2	21	reticulum	reticulum	NOUN
gra-901	2	22	.	.	PUNCT
gra-901	3	1	in	in	ADP
gra-901	3	2	this	this	DET
gra-901	3	3	scenario	scenario	NOUN
gra-901	3	4	,	,	PUNCT
gra-901	3	5	the	the	DET
gra-901	3	6	upr	upr	NOUN
gra-901	3	7	has	have	VERB
gra-901	3	8	three	three	NUM
gra-901	3	9	aims	aim	NOUN
gra-901	3	10	:	:	PUNCT
gra-901	3	11	initially	initially	ADV
gra-901	3	12	to	to	PART
gra-901	3	13	restore	restore	VERB
gra-901	3	14	normal	normal	ADJ
gra-901	3	15	function	function	NOUN
gra-901	3	16	of	of	ADP
gra-901	3	17	the	the	DET
gra-901	3	18	cell	cell	NOUN
gra-901	3	19	by	by	ADP
gra-901	3	20	halting	halt	VERB
gra-901	3	21	protein	protein	NOUN
gra-901	3	22	translation	translation	NOUN
gra-901	3	23	,	,	PUNCT
gra-901	3	24	degrading	degrade	VERB
gra-901	3	25	misfolded	misfolded	ADJ
gra-901	3	26	proteins	protein	NOUN
gra-901	3	27	,	,	PUNCT
gra-901	3	28	and	and	CCONJ
gra-901	3	29	activating	activate	VERB
gra-901	3	30	the	the	DET
gra-901	3	31	signalling	signal	VERB
gra-901	3	32	pathways	pathway	NOUN
gra-901	3	33	that	that	PRON
gra-901	3	34	lead	lead	VERB
gra-901	3	35	to	to	ADP
gra-901	3	36	increasing	increase	VERB
gra-901	3	37	the	the	DET
gra-901	3	38	production	production	NOUN
gra-901	3	39	of	of	ADP
gra-901	3	40	molecular	molecular	ADJ
gra-901	3	41	chaperones	chaperone	NOUN
gra-901	3	42	involved	involve	VERB
gra-901	3	43	in	in	ADP
gra-901	3	44	protein	protein	NOUN
gra-901	3	45	folding	folding	NOUN
gra-901	3	46	.	.	PUNCT
gra-901	4	1	molecular	molecular	ADJ
gra-901	4	2	mechanism	mechanism	NOUN
gra-901	4	3	:	:	PUNCT
gra-901	4	4	the	the	DET
gra-901	4	5	molecular	molecular	PROPN
gra-901	4	6	chaperone	chaperone	PROPN
gra-901	4	7	bip	bip	PROPN
gra-901	4	8	/	/	SYM
gra-901	4	9	grp78maintains	grp78maintain	NOUN
gra-901	4	10	specic	specic	AUX
gra-901	4	11	transmembrane	transmembrane	ADJ
gra-901	4	12	receptor	receptor	NOUN
gra-901	4	13	proteins	protein	NOUN
gra-901	4	14	involved	involve	VERB
gra-901	4	15	in	in	ADP
gra-901	4	16	initiating	initiate	VERB
gra-901	4	17	of	of	ADP
gra-901	4	18	the	the	DET
gra-901	4	19	downstream	downstream	ADJ
gra-901	4	20	signalling	signalling	NOUN
gra-901	4	21	of	of	ADP
gra-901	4	22	the	the	DET
gra-901	4	23	upr	upr	NOUN
gra-901	4	24	in	in	ADP
gra-901	4	25	an	an	DET
gra-901	4	26	inactive	inactive	ADJ
gra-901	4	27	state	state	NOUN
gra-901	4	28	by	by	ADP
gra-901	4	29	binding	bind	VERB
gra-901	4	30	to	to	ADP
gra-901	4	31	their	their	PRON
gra-901	4	32	luminal	luminal	ADJ
gra-901	4	33	domains	domain	NOUN
gra-901	4	34	.	.	PUNCT
gra-901	5	1	an	an	DET
gra-901	5	2	overwhelming	overwhelming	ADJ
gra-901	5	3	load	load	NOUN
gra-901	5	4	of	of	ADP
gra-901	5	5	misfolded	misfolde	VERB
gra-901	5	6	proteins	protein	NOUN
gra-901	5	7	or	or	CCONJ
gra-901	5	8	simply	simply	ADV
gra-901	5	9	the	the	DET
gra-901	5	10	over	over	NOUN
gra-901	5	11	-	-	PUNCT
gra-901	5	12	expression	expression	NOUN
gra-901	5	13	of	of	ADP
gra-901	5	14	proteins	protein	NOUN
gra-901	5	15	[	[	X
gra-901	5	16	1	1	NUM
gra-901	5	17	]	]	PUNCT
gra-901	5	18	requires	require	VERB
gra-901	5	19	more	more	ADJ
gra-901	5	20	of	of	ADP
gra-901	5	21	the	the	DET
gra-901	5	22	available	available	ADJ
gra-901	5	23	bip	bip	PROPN
gra-901	5	24	/	/	SYM
gra-901	5	25	grp78	grp78	NOUN
gra-901	5	26	to	to	PART
gra-901	5	27	bind	bind	VERB
gra-901	5	28	to	to	ADP
gra-901	5	29	the	the	DET
gra-901	5	30	exposed	expose	VERB
gra-901	5	31	hydrophobic	hydrophobic	ADJ
gra-901	5	32	regions	region	NOUN
gra-901	5	33	of	of	ADP
gra-901	5	34	these	these	DET
gra-901	5	35	proteins	protein	NOUN
gra-901	5	36	,	,	PUNCT
gra-901	5	37	and	and	CCONJ
gra-901	5	38	consequently	consequently	ADV
gra-901	5	39	bip	bip	PROPN
gra-901	5	40	/	/	SYM
gra-901	5	41	grp78	grp78	NOUN
gra-901	5	42	dissociates	dissociate	NOUN
gra-901	5	43	from	from	ADP
gra-901	5	44	these	these	DET
gra-901	5	45	receptor	receptor	NOUN
gra-901	5	46	sites	site	NOUN
gra-901	5	47	to	to	PART
gra-901	5	48	meet	meet	VERB
gra-901	5	49	this	this	DET
gra-901	5	50	requirement	requirement	NOUN
gra-901	5	51	.	.	PUNCT
gra-901	6	1	dissociation	dissociation	NOUN
gra-901	6	2	from	from	ADP
gra-901	6	3	the	the	DET
gra-901	6	4	intracellular	intracellular	ADJ
gra-901	6	5	receptor	receptor	NOUN
gra-901	6	6	domains	domain	NOUN
gra-901	6	7	allows	allow	VERB
gra-901	6	8	them	they	PRON
gra-901	6	9	to	to	PART
gra-901	6	10	become	become	VERB
gra-901	6	11	active	active	ADJ
gra-901	6	12	.	.	PUNCT
gra-901	7	1	perk	perk	NOUN
gra-901	7	2	dimerizes	dimerize	NOUN
gra-901	7	3	with	with	ADP
gra-901	7	4	bip	bip	PROPN
gra-901	7	5	in	in	ADP
gra-901	7	6	resting	rest	VERB
gra-901	7	7	cells	cell	NOUN
gra-901	7	8	and	and	CCONJ
gra-901	7	9	oligomerizes	oligomerize	NOUN
gra-901	7	10	in	in	ADP
gra-901	7	11	erstressed	erstresse	VERB
gra-901	7	12	cells	cell	NOUN
gra-901	7	13	.	.	PUNCT
gra-901	8	1	an	an	DET
gra-901	8	2	alternative	alternative	ADJ
gra-901	8	3	model	model	NOUN
gra-901	8	4	has	have	AUX
gra-901	8	5	been	be	AUX
gra-901	8	6	proposed	propose	VERB
gra-901	8	7	,	,	PUNCT
gra-901	8	8	whereby	whereby	SCONJ
gra-901	8	9	unfolded	unfold	VERB
gra-901	8	10	proteins	protein	NOUN
gra-901	8	11	interact	interact	VERB
gra-901	8	12	directly	directly	ADV
gra-901	8	13	with	with	ADP
gra-901	8	14	the	the	DET
gra-901	8	15	erlumenal	erlumenal	ADJ
gra-901	8	16	domain	domain	NOUN
gra-901	8	17	of	of	ADP
gra-901	8	18	ire1	ire1	PROPN
gra-901	8	19	,	,	PUNCT
gra-901	8	20	causing	cause	VERB
gra-901	8	21	oligomerization	oligomerization	NOUN
gra-901	8	22	and	and	CCONJ
gra-901	8	23	transautophosphorylation.[2	transautophosphorylation.[2	NOUN
gra-901	8	24	]	]	PUNCT
gra-901	8	25	the	the	DET
gra-901	8	26	initial	initial	ADJ
gra-901	8	27	phases	phase	NOUN
gra-901	8	28	of	of	ADP
gra-901	8	29	upr	upr	ADJ
gra-901	8	30	activation	activation	NOUN
gra-901	8	31	have	have	VERB
gra-901	8	32	two	two	NUM
gra-901	8	33	key	key	ADJ
gra-901	8	34	roles	role	NOUN
gra-901	8	35	:	:	PUNCT
gra-901	8	36	translation	translation	NOUN
gra-901	8	37	attenuation	attenuation	NOUN
gra-901	8	38	and	and	CCONJ
gra-901	8	39	cell	cell	NOUN
gra-901	8	40	cycle	cycle	NOUN
gra-901	8	41	arrest	arrest	NOUN
gra-901	8	42	by	by	ADP
gra-901	8	43	the	the	DET
gra-901	8	44	perk	perk	ADJ
gra-901	8	45	receptor	receptor	NOUN
gra-901	8	46	this	this	PRON
gra-901	8	47	occurs	occur	VERB
gra-901	8	48	within	within	ADP
gra-901	8	49	minutes	minute	NOUN
gra-901	8	50	to	to	ADP
gra-901	8	51	hours	hour	NOUN
gra-901	8	52	of	of	ADP
gra-901	8	53	upr	upr	ADJ
gra-901	8	54	activation	activation	NOUN
gra-901	8	55	to	to	PART
gra-901	8	56	prevent	prevent	VERB
gra-901	8	57	further	further	ADJ
gra-901	8	58	translational	translational	ADJ
gra-901	8	59	loading	loading	NOUN
gra-901	8	60	of	of	ADP
gra-901	8	61	the	the	DET
gra-901	8	62	er	er	INTJ
gra-901	8	63	.	.	PUNCT
gra-901	8	64	perk	perk	NOUN
gra-901	8	65	(	(	PUNCT
gra-901	8	66	protein	protein	NOUN
gra-901	8	67	kinase	kinase	PROPN
gra-901	8	68	rna	rna	PROPN
gra-901	8	69	-	-	PUNCT
gra-901	8	70	like	like	ADJ
gra-901	8	71	endoplasmic	endoplasmic	ADJ
gra-901	8	72	reticulum	reticulum	NOUN
gra-901	8	73	kinase	kinase	NOUN
gra-901	8	74	)	)	PUNCT
gra-901	8	75	activates	activate	VERB
gra-901	8	76	itself	itself	PRON
gra-901	8	77	by	by	ADP
gra-901	8	78	oligomerization	oligomerization	NOUN
gra-901	8	79	and	and	CCONJ
gra-901	8	80	autophosphorylation	autophosphorylation	NOUN
gra-901	8	81	of	of	ADP
gra-901	8	82	the	the	DET
gra-901	8	83	free	free	ADJ
gra-901	8	84	luminal	luminal	ADJ
gra-901	8	85	domain	domain	NOUN
gra-901	8	86	.	.	PUNCT
gra-901	9	1	the	the	DET
gra-901	9	2	activated	activate	VERB
gra-901	9	3	cytosolic	cytosolic	ADJ
gra-901	9	4	domain	domain	NOUN
gra-901	9	5	causes	cause	VERB
gra-901	9	6	translational	translational	ADJ
gra-901	9	7	attenuation	attenuation	NOUN
gra-901	9	8	by	by	ADP
gra-901	9	9	directly	directly	ADV
gra-901	9	10	phosphorylating	phosphorylate	VERB
gra-901	9	11	the	the	DET
gra-901	9	12	α	α	NOUN
gra-901	9	13	subunit	subunit	NOUN
gra-901	9	14	of	of	ADP
gra-901	9	15	the	the	DET
gra-901	9	16	regulating	regulate	VERB
gra-901	9	17	initiator	initiator	NOUN
gra-901	9	18	of	of	ADP
gra-901	9	19	the	the	DET
gra-901	9	20	mrna	mrna	PROPN
gra-901	9	21	translation	translation	NOUN
gra-901	9	22	machinery	machinery	PROPN
gra-901	9	23	,	,	PUNCT
gra-901	9	24	eif2	eif2	PROPN
gra-901	9	25	.	.	PUNCT
gra-901	10	1	this	this	PRON
gra-901	10	2	also	also	ADV
gra-901	10	3	produces	produce	VERB
gra-901	10	4	translational	translational	ADJ
gra-901	10	5	attenuation	attenuation	NOUN
gra-901	10	6	of	of	ADP
gra-901	10	7	the	the	DET
gra-901	10	8	protein	protein	NOUN
gra-901	10	9	machinery	machinery	NOUN
gra-901	10	10	involved	involve	VERB
gra-901	10	11	in	in	ADP
gra-901	10	12	running	run	VERB
gra-901	10	13	the	the	DET
gra-901	10	14	cell	cell	NOUN
gra-901	10	15	cycle	cycle	NOUN
gra-901	10	16	,	,	PUNCT
gra-901	10	17	producing	produce	VERB
gra-901	10	18	cell	cell	NOUN
gra-901	10	19	cycle	cycle	NOUN
gra-901	10	20	arrest	arrest	NOUN
gra-901	10	21	in	in	ADP
gra-901	10	22	the	the	DET
gra-901	10	23	g1	g1	PROPN
gra-901	10	24	phase[3	phase[3	PROPN
gra-901	10	25	]	]	PUNCT
gra-901	10	26	.	.	PUNCT
gra-901	11	1	perk	perk	NOUN
gra-901	11	2	deciency	deciency	NOUN
gra-901	11	3	may	may	AUX
gra-901	11	4	have	have	VERB
gra-901	11	5	a	a	DET
gra-901	11	6	signicant	signicant	ADJ
gra-901	11	7	impact	impact	NOUN
gra-901	11	8	on	on	ADP
gra-901	11	9	physiological	physiological	ADJ
gra-901	11	10	states	state	NOUN
gra-901	11	11	associated	associate	VERB
gra-901	11	12	with	with	ADP
gra-901	11	13	er	er	INTJ
gra-901	11	14	stress	stress	NOUN
gra-901	11	15	.	.	PUNCT
gra-901	12	1	increased	increase	VERB
gra-901	12	2	production	production	NOUN
gra-901	12	3	of	of	ADP
gra-901	12	4	proteins	protein	NOUN
gra-901	12	5	involved	involve	VERB
gra-901	12	6	in	in	ADP
gra-901	12	7	the	the	DET
gra-901	12	8	functions	function	NOUN
gra-901	12	9	of	of	ADP
gra-901	12	10	the	the	DET
gra-901	12	11	upr	upr	PROPN
gra-901	12	12	upr	upr	NOUN
gra-901	12	13	activation	activation	NOUN
gra-901	12	14	also	also	ADV
gra-901	12	15	results	result	VERB
gra-901	12	16	in	in	ADP
gra-901	12	17	upregulation	upregulation	NOUN
gra-901	12	18	of	of	ADP
gra-901	12	19	proteins	protein	NOUN
gra-901	12	20	involved	involve	VERB
gra-901	12	21	in	in	ADP
gra-901	12	22	chaperoning	chaperone	VERB
gra-901	12	23	malfolding	malfolde	VERB
gra-901	12	24	proteins	protein	NOUN
gra-901	12	25	,	,	PUNCT
gra-901	12	26	protein	protein	NOUN
gra-901	12	27	folding	folding	NOUN
gra-901	12	28	and	and	CCONJ
gra-901	12	29	erad	erad	NOUN
gra-901	12	30	,	,	PUNCT
gra-901	12	31	including	include	VERB
gra-901	12	32	further	further	ADJ
gra-901	12	33	production	production	NOUN
gra-901	12	34	of	of	ADP
gra-901	12	35	grp78	grp78	NOUN
gra-901	12	36	.	.	PUNCT
gra-901	13	1	ultimately	ultimately	ADV
gra-901	13	2	this	this	DET
gra-901	13	3	increases	increase	VERB
gra-901	13	4	the	the	DET
gra-901	13	5	cell	cell	NOUN
gra-901	13	6	's	's	PART
gra-901	13	7	molecular	molecular	ADJ
gra-901	13	8	mechanisms	mechanism	NOUN
gra-901	13	9	by	by	ADP
gra-901	13	10	which	which	PRON
gra-901	13	11	it	it	PRON
gra-901	13	12	can	can	AUX
gra-901	13	13	deal	deal	VERB
gra-901	13	14	with	with	ADP
gra-901	13	15	the	the	DET
gra-901	13	16	misfolded	misfolde	VERB
gra-901	13	17	protein	protein	NOUN
gra-901	13	18	load	load	NOUN
gra-901	13	19	.	.	PUNCT
gra-901	14	1	these	these	DET
gra-901	14	2	receptor	receptor	NOUN
gra-901	14	3	proteins	protein	NOUN
gra-901	14	4	have	have	AUX
gra-901	14	5	been	be	AUX
gra-901	14	6	identied	identied	PROPN
gra-901	14	7	as	as	ADP
gra-901	14	8	:	:	PUNCT
gra-901	14	9	inositol	inositol	NOUN
gra-901	14	10	-	-	PUNCT
gra-901	14	11	requiring	require	VERB
gra-901	14	12	kinase	kinase	NOUN
gra-901	14	13	1[4	1[4	NUM
gra-901	14	14	]	]	PUNCT
gra-901	14	15	,	,	PUNCT
gra-901	14	16	whose	whose	DET
gra-901	14	17	free	free	ADJ
gra-901	14	18	luminal	luminal	ADJ
gra-901	14	19	domain	domain	NOUN
gra-901	14	20	activates	activate	VERB
gra-901	14	21	itself	itself	PRON
gra-901	14	22	by	by	ADP
gra-901	14	23	homodimerisation	homodimerisation	NOUN
gra-901	14	24	and	and	CCONJ
gra-901	14	25	transautopho	transautopho	PROPN
gra-901	14	26	sphorylation[5	sphorylation[5	PROPN
gra-901	14	27	]	]	PUNCT
gra-901	14	28	.	.	PUNCT
gra-901	15	1	the	the	DET
gra-901	15	2	activated	activate	VERB
gra-901	15	3	domain	domain	NOUN
gra-901	15	4	is	be	AUX
gra-901	15	5	able	able	ADJ
gra-901	15	6	to	to	PART
gra-901	15	7	activate	activate	VERB
gra-901	15	8	the	the	DET
gra-901	15	9	transcription	transcription	NOUN
gra-901	15	10	factor	factor	NOUN
gra-901	15	11	xbp1(xbox	xbp1(xbox	NOUN
gra-901	15	12	binding	bind	VERB
gra-901	15	13	protein	protein	NOUN
gra-901	15	14	)	)	PUNCT
gra-901	15	15	mrna	mrna	PROPN
gra-901	15	16	(	(	PUNCT
gra-901	15	17	the	the	DET
gra-901	15	18	mammalian	mammalian	ADJ
gra-901	15	19	equivalent	equivalent	NOUN
gra-901	15	20	of	of	ADP
gra-901	15	21	the	the	DET
gra-901	15	22	yeast	yeast	NOUN
gra-901	15	23	hac1	hac1	PROPN
gra-901	15	24	mrna	mrna	PROPN
gra-901	15	25	)	)	PUNCT
gra-901	15	26	by	by	ADP
gra-901	15	27	cleavage	cleavage	NOUN
gra-901	15	28	and	and	CCONJ
gra-901	15	29	removal	removal	NOUN
gra-901	15	30	of	of	ADP
gra-901	15	31	a	a	DET
gra-901	15	32	26bp	26bp	ADJ
gra-901	15	33	intron	intron	NOUN
gra-901	15	34	.	.	PUNCT
gra-901	16	1	the	the	DET
gra-901	16	2	activated	activate	VERB
gra-901	16	3	transcription	transcription	NOUN
gra-901	16	4	factor	factor	NOUN
gra-901	16	5	upregulates	upregulate	VERB
gra-901	16	6	upr	upr	ADJ
gra-901	16	7	'	'	PUNCT
gra-901	16	8	stress	stress	NOUN
gra-901	16	9	genes	gene	NOUN
gra-901	16	10	'	'	PUNCT
gra-901	16	11	by	by	ADP
gra-901	16	12	directly	directly	ADV
gra-901	16	13	binding	bind	VERB
gra-901	16	14	to	to	ADP
gra-901	16	15	stress	stress	NOUN
gra-901	16	16	element	element	NOUN
gra-901	16	17	promoters	promoter	NOUN
gra-901	16	18	in	in	ADP
gra-901	16	19	the	the	DET
gra-901	16	20	nucleus[6	nucleus[6	NOUN
gra-901	16	21	]	]	PUNCT
gra-901	16	22	.	.	PUNCT
gra-901	17	1	atf6	atf6	PROPN
gra-901	17	2	(	(	PUNCT
gra-901	17	3	activating	activate	VERB
gra-901	17	4	transcription	transcription	NOUN
gra-901	17	5	factor	factor	NOUN
gra-901	17	6	6	6	NUM
gra-901	17	7	)	)	PUNCT
gra-901	17	8	is	be	AUX
gra-901	17	9	a	a	DET
gra-901	17	10	basic	basic	ADJ
gra-901	17	11	leucine	leucine	NOUN
gra-901	17	12	zipper	zipper	NOUN
gra-901	17	13	transcription	transcription	NOUN
gra-901	17	14	factor[7].upon	factor[7].upon	ADP
gra-901	17	15	grp78	grp78	ADJ
gra-901	17	16	dissociation	dissociation	NOUN
gra-901	17	17	,	,	PUNCT
gra-901	17	18	the	the	DET
gra-901	17	19	entire	entire	ADJ
gra-901	17	20	90kda	90kda	NOUN
gra-901	17	21	protein	protein	NOUN
gra-901	17	22	translocates	translocate	NOUN
gra-901	17	23	to	to	ADP
gra-901	17	24	the	the	DET
gra-901	17	25	golgi	golgi	NOUN
gra-901	17	26	,	,	PUNCT
gra-901	17	27	where	where	SCONJ
gra-901	17	28	it	it	PRON
gra-901	17	29	is	be	AUX
gra-901	17	30	cleaved	cleave	VERB
gra-901	17	31	by	by	ADP
gra-901	17	32	proteases	protease	NOUN
gra-901	17	33	to	to	PART
gra-901	17	34	form	form	VERB
gra-901	17	35	an	an	DET
gra-901	17	36	active	active	ADJ
gra-901	17	37	50kda	50kda	NOUN
gra-901	17	38	transcription	transcription	NOUN
gra-901	17	39	factor[8	factor[8	NOUN
gra-901	17	40	]	]	PUNCT
gra-901	17	41	that	that	PRON
gra-901	17	42	translocates	translocate	VERB
gra-901	17	43	to	to	ADP
gra-901	17	44	the	the	DET
gra-901	17	45	nucleus	nucleus	NOUN
gra-901	17	46	.	.	PUNCT
gra-901	18	1	it	it	PRON
gra-901	18	2	binds	bind	VERB
gra-901	18	3	to	to	ADP
gra-901	18	4	stress	stress	NOUN
gra-901	18	5	element	element	NOUN
gra-901	18	6	promoters	promoter	NOUN
gra-901	18	7	upstream	upstream	ADV
gra-901	18	8	of	of	ADP
gra-901	18	9	genes	gene	NOUN
gra-901	18	10	that	that	PRON
gra-901	18	11	are	be	AUX
gra-901	18	12	upregulated	upregulate	VERB
gra-901	18	13	in	in	ADP
gra-901	18	14	the	the	DET
gra-901	18	15	upr	upr	NOUN
gra-901	19	1	[	[	X
gra-901	19	2	9	9	NUM
gra-901	19	3	]	]	PUNCT
gra-901	19	4	.	.	PUNCT
gra-901	20	1	unfolded	unfold	VERB
gra-901	20	2	protein	protein	NOUN
gra-901	20	3	response	response	NOUN
gra-901	20	4	in	in	ADP
gra-901	20	5	cardiovascular	cardiovascular	ADJ
gra-901	20	6	disease	disease	NOUN
gra-901	20	7	2+abnormal	2+abnormal	ADJ
gra-901	20	8	intracellular	intracellular	ADJ
gra-901	20	9	calcium	calcium	NOUN
gra-901	20	10	(	(	PUNCT
gra-901	20	11	ca	ca	NOUN
gra-901	20	12	)	)	PUNCT
gra-901	20	13	handling	handling	NOUN
gra-901	20	14	can	can	AUX
gra-901	20	15	trigger	trigger	VERB
gra-901	20	16	endoplasmic	endoplasmic	ADJ
gra-901	20	17	reticulum	reticulum	NOUN
gra-901	20	18	(	(	PUNCT
gra-901	20	19	er	er	INTJ
gra-901	20	20	)	)	PUNCT
gra-901	20	21	stress	stress	NOUN
gra-901	20	22	,	,	PUNCT
gra-901	20	23	leading	lead	VERB
gra-901	20	24	to	to	ADP
gra-901	20	25	activation	activation	NOUN
gra-901	20	26	of	of	ADP
gra-901	20	27	the	the	DET
gra-901	20	28	unfolded	unfold	VERB
gra-901	20	29	protein	protein	NOUN
gra-901	20	30	response	response	NOUN
gra-901	20	31	(	(	PUNCT
gra-901	20	32	upr	upr	NOUN
gra-901	20	33	)	)	PUNCT
gra-901	20	34	in	in	ADP
gra-901	20	35	an	an	DET
gra-901	20	36	attempt	attempt	NOUN
gra-901	20	37	to	to	PART
gra-901	20	38	prevent	prevent	VERB
gra-901	20	39	cell	cell	NOUN
gra-901	20	40	death	death	NOUN
gra-901	20	41	.	.	PUNCT
gra-901	21	1	mechanical	mechanical	ADJ
gra-901	21	2	unloading	unloading	NOUN
gra-901	21	3	with	with	ADP
gra-901	21	4	a	a	DET
gra-901	21	5	left	left	ADJ
gra-901	21	6	ventricular	ventricular	ADJ
gra-901	21	7	assist	assist	NOUN
gra-901	21	8	device	device	NOUN
gra-901	21	9	(	(	PUNCT
gra-901	21	10	lvad	lvad	NOUN
gra-901	21	11	)	)	PUNCT
gra-901	21	12	relieves	relieve	VERB
gra-901	21	13	pressure	pressure	NOUN
gra-901	21	14	-	-	PUNCT
gra-901	21	15	volume	volume	NOUN
gra-901	21	16	overload	overload	NOUN
gra-901	21	17	and	and	CCONJ
gra-901	21	18	promotes	promote	VERB
gra-901	21	19	reverse	reverse	ADJ
gra-901	21	20	remodeling	remodeling	NOUN
gra-901	21	21	of	of	ADP
gra-901	21	22	the	the	DET
gra-901	21	23	failing	fail	VERB
gra-901	21	24	myocardium	myocardium	NOUN
gra-901	21	25	.	.	PUNCT
gra-901	22	1	estibaliz	estibaliz	NOUN
gra-901	22	2	castillero	castillero	PROPN
gra-901	22	3	et	et	PROPN
gra-901	22	4	al	al	PROPN
gra-901	22	5	hypothesized	hypothesize	VERB
gra-901	22	6	that	that	SCONJ
gra-901	22	7	mechanical	mechanical	ADJ
gra-901	22	8	unloading	unloading	NOUN
gra-901	22	9	would	would	AUX
gra-901	22	10	alter	alter	VERB
gra-901	22	11	the	the	DET
gra-901	22	12	upr	upr	NOUN
gra-901	22	13	in	in	ADP
gra-901	22	14	patients	patient	NOUN
gra-901	22	15	with	with	ADP
gra-901	22	16	advanced	advanced	ADJ
gra-901	22	17	role	role	NOUN
gra-901	22	18	of	of	ADP
gra-901	22	19	unfolded	unfold	VERB
gra-901	22	20	protein	protein	NOUN
gra-901	22	21	response	response	NOUN
gra-901	22	22	in	in	ADP
gra-901	22	23	cardiac	cardiac	ADJ
gra-901	22	24	diseases	disease	NOUN
gra-901	22	25	.	.	PUNCT
gra-901	23	1	original	original	ADJ
gra-901	23	2	research	research	NOUN
gra-901	23	3	paper	paper	NOUN
gra-901	23	4	smita	smita	PROPN
gra-901	23	5	sharma	sharma	PROPN
gra-901	23	6	*	*	PROPN
gra-901	23	7	md	md	PROPN
gra-901	23	8	,	,	PUNCT
gra-901	23	9	dtcd	dtcd	NOUN
gra-901	23	10	,	,	PUNCT
gra-901	23	11	clinical	clinical	ADJ
gra-901	23	12	biochemist	biochemist	NOUN
gra-901	23	13	,	,	PUNCT
gra-901	23	14	regional	regional	ADJ
gra-901	23	15	lab	lab	NOUN
gra-901	23	16	.	.	PUNCT
gra-901	23	17	,nejran.[ksa	,nejran.[ksa	PROPN
gra-901	23	18	]	]	PUNCT
gra-901	24	1	*	*	PUNCT
gra-901	24	2	corresponding	correspond	VERB
gra-901	24	3	author	author	NOUN
gra-901	24	4	biochemistry	biochemistry	NOUN
gra-901	24	5	cardiovascular	cardiovascular	ADJ
gra-901	24	6	disease	disease	NOUN
gra-901	24	7	is	be	AUX
gra-901	24	8	the	the	DET
gra-901	24	9	leading	lead	VERB
gra-901	24	10	cause	cause	NOUN
gra-901	24	11	of	of	ADP
gra-901	24	12	death	death	NOUN
gra-901	24	13	worldwide	worldwide	ADV
gra-901	24	14	.	.	PUNCT
gra-901	25	1	multiple	multiple	ADJ
gra-901	25	2	forms	form	NOUN
gra-901	25	3	of	of	ADP
gra-901	25	4	the	the	DET
gra-901	25	5	cardiovascular	cardiovascular	ADJ
gra-901	25	6	disease	disease	NOUN
gra-901	25	7	involve	involve	VERB
gra-901	25	8	acute	acute	ADJ
gra-901	25	9	or	or	CCONJ
gra-901	25	10	chronic	chronic	ADJ
gra-901	25	11	disturbance	disturbance	NOUN
gra-901	25	12	in	in	ADP
gra-901	25	13	cardiac	cardiac	ADJ
gra-901	25	14	myocytes	myocyte	NOUN
gra-901	25	15	,	,	PUNCT
gra-901	25	16	which	which	PRON
gra-901	25	17	may	may	AUX
gra-901	25	18	lead	lead	VERB
gra-901	25	19	to	to	ADP
gra-901	25	20	potent	potent	ADJ
gra-901	25	21	activation	activation	NOUN
gra-901	25	22	of	of	ADP
gra-901	25	23	the	the	DET
gra-901	25	24	unfolded	unfold	VERB
gra-901	25	25	protein	protein	NOUN
gra-901	25	26	response	response	NOUN
gra-901	25	27	(	(	PUNCT
gra-901	25	28	upr	upr	NOUN
gra-901	25	29	)	)	PUNCT
gra-901	25	30	,	,	PUNCT
gra-901	25	31	a	a	DET
gra-901	25	32	cellular	cellular	ADJ
gra-901	25	33	adaptive	adaptive	ADJ
gra-901	25	34	reaction	reaction	NOUN
gra-901	25	35	to	to	PART
gra-901	25	36	accommodate	accommodate	VERB
gra-901	25	37	protein	protein	NOUN
gra-901	25	38	-	-	PUNCT
gra-901	25	39	folding	fold	VERB
gra-901	25	40	stress	stress	NOUN
gra-901	25	41	.	.	PUNCT
gra-901	26	1	ample	ample	ADJ
gra-901	26	2	evidence	evidence	NOUN
gra-901	26	3	has	have	AUX
gra-901	26	4	rmly	rmly	ADV
gra-901	26	5	established	establish	VERB
gra-901	26	6	that	that	SCONJ
gra-901	26	7	the	the	DET
gra-901	26	8	upr	upr	NOUN
gra-901	26	9	is	be	AUX
gra-901	26	10	strongly	strongly	ADV
gra-901	26	11	induced	induce	VERB
gra-901	26	12	in	in	ADP
gra-901	26	13	heart	heart	NOUN
gra-901	26	14	disease	disease	NOUN
gra-901	26	15	.	.	PUNCT
gra-901	27	1	recently	recently	ADV
gra-901	27	2	,	,	PUNCT
gra-901	27	3	the	the	DET
gra-901	27	4	mechanism	mechanism	NOUN
gra-901	27	5	of	of	ADP
gra-901	27	6	action	action	NOUN
gra-901	27	7	and	and	CCONJ
gra-901	27	8	multiple	multiple	ADJ
gra-901	27	9	pharmacological	pharmacological	NOUN
gra-901	27	10	means	mean	NOUN
gra-901	27	11	to	to	PART
gra-901	27	12	favorably	favorably	ADV
gra-901	27	13	modulate	modulate	VERB
gra-901	27	14	the	the	DET
gra-901	27	15	upr	upr	NOUN
gra-901	27	16	are	be	AUX
gra-901	27	17	emerging	emerge	VERB
gra-901	27	18	to	to	PART
gra-901	27	19	curb	curb	VERB
gra-901	27	20	the	the	DET
gra-901	27	21	initiation	initiation	NOUN
gra-901	27	22	and	and	CCONJ
gra-901	27	23	progression	progression	NOUN
gra-901	27	24	of	of	ADP
gra-901	27	25	cardiovascular	cardiovascular	ADJ
gra-901	27	26	disease.in	disease.in	PRON
gra-901	27	27	this	this	DET
gra-901	27	28	review	review	NOUN
gra-901	27	29	we	we	PRON
gra-901	27	30	tried	try	VERB
gra-901	27	31	to	to	PART
gra-901	27	32	focus	focus	VERB
gra-901	27	33	the	the	DET
gra-901	27	34	unfolded	unfolded	ADJ
gra-901	27	35	protein	protein	NOUN
gra-901	27	36	response	response	NOUN
gra-901	27	37	in	in	ADP
gra-901	27	38	cardiovascular	cardiovascular	ADJ
gra-901	27	39	disease	disease	NOUN
gra-901	27	40	.	.	PUNCT
gra-901	28	1	modulating	modulate	VERB
gra-901	28	2	the	the	DET
gra-901	28	3	upr	upr	NOUN
gra-901	28	4	may	may	AUX
gra-901	28	5	be	be	AUX
gra-901	28	6	clinically	clinically	ADV
gra-901	28	7	benecial	benecial	ADJ
gra-901	28	8	.	.	PUNCT
gra-901	29	1	for	for	ADP
gra-901	29	2	example	example	NOUN
gra-901	29	3	,	,	PUNCT
gra-901	29	4	in	in	ADP
gra-901	29	5	heart	heart	NOUN
gra-901	29	6	failure	failure	NOUN
gra-901	29	7	,	,	PUNCT
gra-901	29	8	upr	upr	ADJ
gra-901	29	9	activation	activation	NOUN
gra-901	29	10	contributes	contribute	VERB
gra-901	29	11	to	to	ADP
gra-901	29	12	arrhythmic	arrhythmic	ADJ
gra-901	29	13	risk	risk	NOUN
gra-901	29	14	and	and	CCONJ
gra-901	29	15	inhibiting	inhibit	VERB
gra-901	29	16	the	the	DET
gra-901	29	17	upr	upr	NOUN
gra-901	29	18	may	may	AUX
gra-901	29	19	decrease	decrease	VERB
gra-901	29	20	that	that	DET
gra-901	29	21	risk	risk	NOUN
gra-901	29	22	.	.	PUNCT
gra-901	30	1	targeting	target	VERB
gra-901	30	2	the	the	DET
gra-901	30	3	upr	upr	NOUN
gra-901	30	4	seems	seem	VERB
gra-901	30	5	to	to	PART
gra-901	30	6	be	be	AUX
gra-901	30	7	a	a	DET
gra-901	30	8	potentially	potentially	ADV
gra-901	30	9	fruitful	fruitful	ADJ
gra-901	30	10	approach	approach	NOUN
gra-901	30	11	in	in	ADP
gra-901	30	12	novel	novel	ADJ
gra-901	30	13	therapeutics	therapeutic	NOUN
gra-901	30	14	for	for	ADP
gra-901	30	15	cardiac	cardiac	ADJ
gra-901	30	16	disease	disease	NOUN
gra-901	30	17	.	.	PUNCT
gra-901	31	1	abstract	abstract	ADJ
gra-901	31	2	keywords	keyword	NOUN
gra-901	31	3	:	:	PUNCT
gra-901	31	4	cardiovascular	cardiovascular	ADJ
gra-901	31	5	disease	disease	NOUN
gra-901	31	6	,	,	PUNCT
gra-901	31	7	unfolded	unfold	VERB
gra-901	31	8	protein	protein	NOUN
gra-901	31	9	response	response	NOUN
gra-901	31	10	,	,	PUNCT
gra-901	31	11	arrythmias	arrythmias	PROPN
gra-901	31	12	.	.	PUNCT
gra-901	32	1	rami	rami	PROPN
gra-901	32	2	abdullah	abdullah	PROPN
gra-901	32	3	ali	ali	PROPN
gra-901	32	4	al	al	PROPN
gra-901	32	5	dagrer	dagrer	PROPN
gra-901	32	6	master	master	PROPN
gra-901	32	7	in	in	ADP
gra-901	32	8	biotechnology	biotechnology	NOUN
gra-901	32	9	,	,	PUNCT
gra-901	32	10	director	director	NOUN
gra-901	32	11	blood	blood	NOUN
gra-901	32	12	banks	bank	NOUN
gra-901	32	13	and	and	CCONJ
gra-901	32	14	laboratories	laboratory	NOUN
gra-901	32	15	,	,	PUNCT
gra-901	32	16	nejran	nejran	ADJ
gra-901	32	17	zone.[ksa	zone.[ksa	NOUN
gra-901	32	18	]	]	PUNCT
gra-901	32	19	ramesh	ramesh	PROPN
gra-901	32	20	maheshwari	maheshwari	PROPN
gra-901	32	21	md.(medicine),general	md.(medicine),general	PROPN
gra-901	32	22	physician	physician	NOUN
gra-901	32	23	,	,	PUNCT
gra-901	32	24	punjab	punjab	ADJ
gra-901	32	25	civil	civil	ADJ
gra-901	32	26	medical	medical	ADJ
gra-901	32	27	services	service	NOUN
gra-901	32	28	,	,	PUNCT
gra-901	32	29	bhatinda	bhatinda	PROPN
gra-901	33	1	[	[	X
gra-901	33	2	india	india	X
gra-901	33	3	]	]	X
gra-901	33	4	sk	sk	PROPN
gra-901	33	5	mathur	mathur	PROPN
gra-901	33	6	dm(endo	dm(endo	PROPN
gra-901	33	7	)	)	PUNCT
gra-901	33	8	,	,	PUNCT
gra-901	33	9	md(paediatrics	md(paediatrics	PROPN
gra-901	33	10	)	)	PUNCT
gra-901	33	11	,	,	PUNCT
gra-901	33	12	consultant	consultant	NOUN
gra-901	33	13	endocrinologist	endocrinologist	NOUN
gra-901	33	14	,	,	PUNCT
gra-901	33	15	max.hospital	max.hospital	NOUN
gra-901	33	16	,	,	PUNCT
gra-901	33	17	chandigarh.[india	chandigarh.[india	PROPN
gra-901	33	18	]	]	PUNCT
gra-901	33	19	simmi	simmi	PROPN
gra-901	33	20	kharab	kharab	PROPN
gra-901	33	21	md(biochemistry	md(biochemistry	PROPN
gra-901	33	22	)	)	PUNCT
gra-901	33	23	,	,	PUNCT
gra-901	33	24	sr.prof.&head	sr.prof.&head	NOUN
gra-901	33	25	,	,	PUNCT
gra-901	33	26	pgims	pgim	NOUN
gra-901	33	27	,	,	PUNCT
gra-901	33	28	rohtak.[india	rohtak.[india	X
gra-901	33	29	]	]	PUNCT
gra-901	33	30	volume-8	volume-8	NUM
gra-901	33	31	,	,	PUNCT
gra-901	33	32	issue-12	issue-12	NOUN
gra-901	33	33	,	,	PUNCT
gra-901	33	34	december-2019	december-2019	ADJ
gra-901	33	35	•	•	NUM
gra-901	33	36	print	print	NOUN
gra-901	33	37	issn	issn	PROPN
gra-901	33	38	no	no	NOUN
gra-901	33	39	.	.	PROPN
gra-901	33	40	2277	2277	NUM
gra-901	33	41	8160	8160	NUM
gra-901	33	42	•	•	NOUN
gra-901	33	43	doi	doi	NOUN
gra-901	33	44	:	:	PUNCT
gra-901	33	45	10.36106	10.36106	NUM
gra-901	33	46	/	/	SYM
gra-901	33	47	gjra	gjra	NOUN
gra-901	33	48	18	18	NUM
gra-901	33	49	x	x	NOUN
gra-901	33	50	gjra	gjra	ADJ
gra-901	33	51	global	global	ADJ
gra-901	33	52	journal	journal	PROPN
gra-901	33	53	for	for	ADP
gra-901	33	54	research	research	NOUN
gra-901	33	55	analysis	analysis	NOUN
gra-901	33	56	heart	heart	NOUN
gra-901	33	57	failure	failure	NOUN
gra-901	33	58	(	(	PUNCT
gra-901	33	59	hf	hf	NOUN
gra-901	33	60	)	)	PUNCT
gra-901	33	61	.	.	PUNCT
gra-901	34	1	upr	upr	PROPN
gra-901	34	2	was	be	AUX
gra-901	34	3	analyzed	analyze	VERB
gra-901	34	4	in	in	ADP
gra-901	34	5	paired	pair	VERB
gra-901	34	6	myocardial	myocardial	ADJ
gra-901	34	7	tissue	tissue	NOUN
gra-901	34	8	from	from	ADP
gra-901	34	9	10	10	NUM
gra-901	34	10	patients	patient	NOUN
gra-901	34	11	with	with	ADP
gra-901	34	12	dilated	dilate	VERB
gra-901	34	13	cardiomyopathy	cardiomyopathy	ADJ
gra-901	34	14	obtained	obtain	VERB
gra-901	34	15	during	during	ADP
gra-901	34	16	lvad	lvad	ADJ
gra-901	34	17	implantation	implantation	NOUN
gra-901	34	18	and	and	CCONJ
gra-901	34	19	explantation	explantation	NOUN
gra-901	34	20	.	.	PUNCT
gra-901	35	1	samples	sample	NOUN
gra-901	35	2	from	from	ADP
gra-901	35	3	healthy	healthy	ADJ
gra-901	35	4	hearts	heart	NOUN
gra-901	35	5	served	serve	VERB
gra-901	35	6	as	as	ADP
gra-901	35	7	controls	control	NOUN
gra-901	35	8	.	.	PUNCT
gra-901	36	1	markers	marker	NOUN
gra-901	36	2	of	of	ADP
gra-901	36	3	upr	upr	NOUN
gra-901	37	1	[	[	X
gra-901	37	2	binding	bind	VERB
gra-901	37	3	immunoglobulin	immunoglobulin	NOUN
gra-901	37	4	protein	protein	NOUN
gra-901	37	5	(	(	PUNCT
gra-901	37	6	bip	bip	PROPN
gra-901	37	7	)	)	PUNCT
gra-901	37	8	,	,	PUNCT
gra-901	37	9	phosphorylated	phosphorylate	VERB
gra-901	37	10	(	(	PUNCT
gra-901	37	11	p-	p-	X
gra-901	37	12	)	)	PUNCT
gra-901	37	13	eukaryotic	eukaryotic	ADJ
gra-901	37	14	initiation	initiation	NOUN
gra-901	37	15	factor	factor	NOUN
gra-901	37	16	(	(	PUNCT
gra-901	37	17	eif2	eif2	PROPN
gra-901	37	18	�	�	PROPN
gra-901	37	19	)	)	PUNCT
gra-901	37	20	,	,	PUNCT
gra-901	37	21	and	and	CCONJ
gra-901	37	22	x	x	X
gra-901	37	23	-	-	NOUN
gra-901	37	24	box	box	NOUN
gra-901	37	25	binding	bind	VERB
gra-901	37	26	protein	protein	NOUN
gra-901	37	27	(	(	PUNCT
gra-901	37	28	xbp1	xbp1	PROPN
gra-901	37	29	)	)	PUNCT
gra-901	37	30	were	be	AUX
gra-901	37	31	signicantly	signicantly	ADV
gra-901	37	32	increased	increase	VERB
gra-901	37	33	in	in	ADP
gra-901	37	34	hf	hf	NOUN
gra-901	37	35	,	,	PUNCT
gra-901	37	36	whereas	whereas	SCONJ
gra-901	37	37	lvad	lvad	NOUN
gra-901	37	38	support	support	PROPN
gra-901	37	39	signicantly	signicantly	ADV
gra-901	37	40	decreased	decrease	VERB
gra-901	37	41	bip	bip	PROPN
gra-901	37	42	,	,	PUNCT
gra-901	37	43	p	p	PROPN
gra-901	37	44	-	-	PUNCT
gra-901	37	45	eif2	eif2	NOUN
gra-901	37	46	�	�	PROPN
gra-901	37	47	,	,	PUNCT
gra-901	37	48	and	and	CCONJ
gra-901	37	49	xbp1s	xbp1s	PROPN
gra-901	37	50	levels	level	NOUN
gra-901	37	51	.	.	PUNCT
gra-901	38	1	apoptosis	apoptosis	NOUN
gra-901	38	2	as	as	SCONJ
gra-901	38	3	reected	reecte	VERB
gra-901	38	4	by	by	ADP
gra-901	38	5	c	c	PROPN
gra-901	38	6	/	/	SYM
gra-901	38	7	ebp	ebp	PROPN
gra-901	38	8	homologous	homologous	ADJ
gra-901	38	9	protein	protein	NOUN
gra-901	38	10	and	and	CCONJ
gra-901	38	11	dna	dna	PROPN
gra-901	38	12	damage	damage	NOUN
gra-901	38	13	were	be	AUX
gra-901	38	14	also	also	ADV
gra-901	38	15	signicantly	signicantly	ADV
gra-901	38	16	reduced	reduce	VERB
gra-901	38	17	after	after	ADP
gra-901	38	18	lvad	lvad	NOUN
gra-901	38	19	support	support	NOUN
gra-901	38	20	.	.	PUNCT
gra-901	39	1	improvement	improvement	NOUN
gra-901	39	2	in	in	ADP
gra-901	39	3	left	left	ADJ
gra-901	39	4	ventricular	ventricular	ADJ
gra-901	39	5	dimensions	dimension	NOUN
gra-901	39	6	positively	positively	ADV
gra-901	39	7	correlated	correlate	VERB
gra-901	39	8	with	with	ADP
gra-901	39	9	p	p	NOUN
gra-901	39	10	-	-	PUNCT
gra-901	39	11	eif2	eif2	PROPN
gra-901	39	12	�	�	PROPN
gra-901	39	13	/eif2	/eif2	NOUN
gra-901	39	14	�	�	PROPN
gra-901	39	15	and	and	CCONJ
gra-901	39	16	apoptosis	apoptosis	NOUN
gra-901	39	17	level	level	NOUN
gra-901	39	18	recovery[10	recovery[10	X
gra-901	39	19	]	]	PUNCT
gra-901	39	20	.	.	PUNCT
gra-901	40	1	sen	sen	PROPN
gra-901	40	2	et	et	PROPN
gra-901	40	3	al	al	PROPN
gra-901	40	4	.	.	PUNCT
gra-901	41	1	[	[	X
gra-901	41	2	11]have	11]have	NUM
gra-901	41	3	previously	previously	ADV
gra-901	41	4	suggested	suggest	VERB
gra-901	41	5	an	an	DET
gra-901	41	6	attenuation	attenuation	NOUN
gra-901	41	7	of	of	ADP
gra-901	41	8	the	the	DET
gra-901	41	9	upr	upr	NOUN
gra-901	41	10	by	by	ADP
gra-901	41	11	mechanical	mechanical	ADJ
gra-901	41	12	unloading	unloading	NOUN
gra-901	41	13	in	in	ADP
gra-901	41	14	hf	hf	ADJ
gra-901	41	15	patients	patient	NOUN
gra-901	41	16	.	.	PUNCT
gra-901	42	1	these	these	DET
gra-901	42	2	authors	author	NOUN
gra-901	42	3	reported	report	VERB
gra-901	42	4	a	a	DET
gra-901	42	5	decrease	decrease	NOUN
gra-901	42	6	in	in	ADP
gra-901	42	7	the	the	DET
gra-901	42	8	er	er	INTJ
gra-901	42	9	chaperones	chaperone	NOUN
gra-901	42	10	grp72	grp72	PROPN
gra-901	42	11	,	,	PUNCT
gra-901	42	12	grp94	grp94	PROPN
gra-901	42	13	,	,	PUNCT
gra-901	42	14	and	and	CCONJ
gra-901	42	15	bip	bip	PROPN
gra-901	42	16	in	in	ADP
gra-901	42	17	hf	hf	PROPN
gra-901	42	18	patients	patient	NOUN
gra-901	42	19	after	after	ADP
gra-901	42	20	lvad	lvad	NOUN
gra-901	42	21	support	support	PROPN
gra-901	42	22	.	.	PUNCT
gra-901	43	1	lvad	lvad	NOUN
gra-901	43	2	-	-	PUNCT
gra-901	43	3	induced	induce	VERB
gra-901	43	4	reverse	reverse	ADJ
gra-901	43	5	remodeling	remodeling	NOUN
gra-901	43	6	is	be	AUX
gra-901	43	7	accompanied	accompany	VERB
gra-901	43	8	by	by	ADP
gra-901	43	9	improvement	improvement	NOUN
gra-901	43	10	in	in	ADP
gra-901	43	11	�	�	NOUN
gra-901	43	12	-adrenergic	-adrenergic	ADJ
gra-901	43	13	signal	signal	NOUN
gra-901	43	14	transduction	transduction	NOUN
gra-901	43	15	,	,	PUNCT
gra-901	43	16	lower	low	ADJ
gra-901	43	17	natriuretic	natriuretic	ADJ
gra-901	43	18	peptide	peptide	NOUN
gra-901	43	19	levels	level	NOUN
gra-901	43	20	,	,	PUNCT
gra-901	43	21	increased	increase	VERB
gra-901	43	22	cell	cell	NOUN
gra-901	43	23	viability	viability	NOUN
gra-901	43	24	,	,	PUNCT
gra-901	43	25	and	and	CCONJ
gra-901	43	26	reduced	reduce	VERB
gra-901	43	27	inammation	inammation	NOUN
gra-901	43	28	.	.	PUNCT
gra-901	44	1	it	it	PRON
gra-901	44	2	is	be	AUX
gra-901	44	3	likely	likely	ADJ
gra-901	44	4	that	that	SCONJ
gra-901	44	5	these	these	DET
gra-901	44	6	effects	effect	NOUN
gra-901	44	7	are	be	AUX
gra-901	44	8	partially	partially	ADV
gra-901	44	9	2+mediated	2+mediate	VERB
gra-901	44	10	not	not	PART
gra-901	44	11	only	only	ADV
gra-901	44	12	by	by	ADP
gra-901	44	13	an	an	DET
gra-901	44	14	improvement	improvement	NOUN
gra-901	44	15	in	in	ADP
gra-901	44	16	ca	ca	NOUN
gra-901	44	17	cycling	cycling	NOUN
gra-901	44	18	but	but	CCONJ
gra-901	44	19	also	also	ADV
gra-901	44	20	improvement	improvement	NOUN
gra-901	44	21	in	in	ADP
gra-901	44	22	upr	upr	PROPN
gra-901	44	23	.	.	PUNCT
gra-901	45	1	the	the	DET
gra-901	45	2	er	er	INTJ
gra-901	45	3	is	be	AUX
gra-901	45	4	recognized	recognize	VERB
gra-901	45	5	as	as	ADP
gra-901	45	6	a	a	DET
gra-901	45	7	vitally	vitally	ADV
gra-901	45	8	important	important	ADJ
gra-901	45	9	organelle	organelle	NOUN
gra-901	45	10	that	that	PRON
gra-901	45	11	determines	determine	VERB
gra-901	45	12	cell	cell	NOUN
gra-901	45	13	survival	survival	NOUN
gra-901	45	14	or	or	CCONJ
gra-901	45	15	death	death	NOUN
gra-901	45	16	.	.	PUNCT
gra-901	46	1	upr	upr	PROPN
gra-901	46	2	plays	play	VERB
gra-901	46	3	critical	critical	ADJ
gra-901	46	4	roles	role	NOUN
gra-901	46	5	in	in	ADP
gra-901	46	6	the	the	DET
gra-901	46	7	pathophysiology	pathophysiology	NOUN
gra-901	46	8	of	of	ADP
gra-901	46	9	ischemic	ischemic	ADJ
gra-901	46	10	heart	heart	NOUN
gra-901	46	11	disease	disease	NOUN
gra-901	46	12	.	.	PUNCT
gra-901	47	1	the	the	DET
gra-901	47	2	three	three	NUM
gra-901	47	3	signaling	signal	VERB
gra-901	47	4	branches	branch	NOUN
gra-901	47	5	may	may	AUX
gra-901	47	6	elicit	elicit	VERB
gra-901	47	7	distinct	distinct	ADJ
gra-901	47	8	but	but	CCONJ
gra-901	47	9	overlapping	overlap	VERB
gra-901	47	10	effects	effect	NOUN
gra-901	47	11	in	in	ADP
gra-901	47	12	cardiac	cardiac	ADJ
gra-901	47	13	response	response	NOUN
gra-901	47	14	to	to	ADP
gra-901	47	15	ischemia	ischemia	NOUN
gra-901	47	16	.	.	PUNCT
gra-901	48	1	cardiac	cardiac	ADJ
gra-901	48	2	injury	injury	NOUN
gra-901	48	3	results	result	NOUN
gra-901	48	4	in	in	ADP
gra-901	48	5	upr	upr	ADJ
gra-901	48	6	activation	activation	NOUN
gra-901	48	7	,	,	PUNCT
gra-901	48	8	which	which	PRON
gra-901	48	9	induces	induce	VERB
gra-901	48	10	ion	ion	NOUN
gra-901	48	11	channel	channel	NOUN
gra-901	48	12	downregulations	downregulation	NOUN
gra-901	48	13	.	.	PUNCT
gra-901	49	1	these	these	DET
gra-901	49	2	downregulations	downregulation	NOUN
gra-901	49	3	can	can	AUX
gra-901	49	4	explain	explain	VERB
gra-901	49	5	some	some	PRON
gra-901	49	6	of	of	ADP
gra-901	49	7	the	the	DET
gra-901	49	8	arrhythmic	arrhythmic	ADJ
gra-901	49	9	risk	risk	NOUN
gra-901	49	10	.	.	PUNCT
gra-901	50	1	downregulation	downregulation	NOUN
gra-901	50	2	of	of	ADP
gra-901	50	3	multiple	multiple	ADJ
gra-901	50	4	cardiac	cardiac	ADJ
gra-901	50	5	ion	ion	NOUN
gra-901	50	6	channels	channel	NOUN
gra-901	50	7	corresponds	correspond	VERB
gra-901	50	8	to	to	ADP
gra-901	50	9	the	the	DET
gra-901	50	10	apd	apd	PROPN
gra-901	50	11	prolongation	prolongation	NOUN
gra-901	50	12	and	and	CCONJ
gra-901	50	13	dv	dv	PROPN
gra-901	50	14	/	/	SYM
gra-901	50	15	dtmax	dtmax	ADJ
gra-901	50	16	reduction	reduction	NOUN
gra-901	50	17	[	[	X
gra-901	50	18	١٢	١٢	NUM
gra-901	50	19	]	]	PUNCT
gra-901	50	20	.	.	PUNCT
gra-901	51	1	inhibition	inhibition	NOUN
gra-901	51	2	of	of	ADP
gra-901	51	3	either	either	CCONJ
gra-901	51	4	the	the	DET
gra-901	51	5	perk	perk	NOUN
gra-901	51	6	or	or	CCONJ
gra-901	51	7	ire1	ire1	ADJ
gra-901	51	8	arm	arm	NOUN
gra-901	51	9	led	lead	VERB
gra-901	51	10	to	to	ADP
gra-901	51	11	a	a	DET
gra-901	51	12	shortened	shorten	VERB
gra-901	51	13	apd	apd	PROPN
gra-901	51	14	and	and	CCONJ
gra-901	51	15	recovered	recover	VERB
gra-901	51	16	dv	dv	PROPN
gra-901	51	17	/	/	SYM
gra-901	51	18	dtmax	dtmax	PROPN
gra-901	51	19	.	.	PUNCT
gra-901	52	1	this	this	PRON
gra-901	52	2	suggests	suggest	VERB
gra-901	52	3	that	that	SCONJ
gra-901	52	4	perkand	perkand	X
gra-901	52	5	ire1	ire1	ADV
gra-901	52	6	-	-	PUNCT
gra-901	52	7	mediated	mediate	VERB
gra-901	52	8	channel	channel	NOUN
gra-901	52	9	downregulations	downregulation	NOUN
gra-901	52	10	are	be	AUX
gra-901	52	11	specic	specic	ADJ
gra-901	52	12	for	for	ADP
gra-901	52	13	a	a	DET
gra-901	52	14	certain	certain	ADJ
gra-901	52	15	set	set	NOUN
gra-901	52	16	of	of	ADP
gra-901	52	17	channels	channel	NOUN
gra-901	52	18	,	,	PUNCT
gra-901	52	19	and	and	CCONJ
gra-901	52	20	that	that	SCONJ
gra-901	52	21	some	some	DET
gra-901	52	22	cross	cross	NOUN
gra-901	52	23	talk	talk	NOUN
gra-901	52	24	exists	exist	VERB
gra-901	52	25	between	between	ADP
gra-901	52	26	the	the	DET
gra-901	52	27	perk	perk	NOUN
gra-901	52	28	and	and	CCONJ
gra-901	52	29	ire1	ire1	ADJ
gra-901	52	30	arms	arm	NOUN
gra-901	52	31	of	of	ADP
gra-901	52	32	upr	upr	PROPN
gra-901	52	33	.	.	PUNCT
gra-901	53	1	with	with	ADP
gra-901	53	2	4µ8c	4µ8c	NOUN
gra-901	53	3	[	[	X
gra-901	53	4	١٢	١٢	NUM
gra-901	53	5	]	]	PUNCT
gra-901	53	6	,	,	PUNCT
gra-901	53	7	suggesting	suggest	VERB
gra-901	53	8	that	that	SCONJ
gra-901	53	9	the	the	DET
gra-901	53	10	upr	upr	NOUN
gra-901	53	11	results	result	VERB
gra-901	53	12	in	in	ADP
gra-901	53	13	changes	change	NOUN
gra-901	53	14	in	in	ADP
gra-901	53	15	post	post	ADJ
gra-901	53	16	-	-	ADJ
gra-901	53	17	translational	translational	ADJ
gra-901	53	18	modications	modication	NOUN
gra-901	53	19	of	of	ADP
gra-901	53	20	nav1.5	nav1.5	NOUN
gra-901	53	21	or	or	CCONJ
gra-901	53	22	possibly	possibly	ADV
gra-901	53	23	changes	change	NOUN
gra-901	53	24	in	in	ADP
gra-901	53	25	associated	associated	ADJ
gra-901	53	26	channel	channel	NOUN
gra-901	53	27	subunits	subunit	NOUN
gra-901	53	28	.	.	PUNCT
gra-901	54	1	it	it	PRON
gra-901	54	2	is	be	AUX
gra-901	54	3	noteworthy	noteworthy	ADJ
gra-901	54	4	that	that	SCONJ
gra-901	54	5	inhibition	inhibition	NOUN
gra-901	54	6	of	of	ADP
gra-901	54	7	ire1	ire1	PROPN
gra-901	54	8	under	under	ADP
gra-901	54	9	physiological	physiological	ADJ
gra-901	54	10	condition	condition	NOUN
gra-901	54	11	downregulates	downregulate	VERB
gra-901	54	12	cav1.2	cav1.2	PROPN
gra-901	54	13	,	,	PUNCT
gra-901	54	14	herg	herg	PROPN
gra-901	54	15	and	and	CCONJ
gra-901	54	16	kvlqt1	kvlqt1	PROPN
gra-901	54	17	and	and	CCONJ
gra-901	54	18	prolongs	prolong	VERB
gra-901	54	19	the	the	DET
gra-901	54	20	apd	apd	PROPN
gra-901	54	21	,	,	PUNCT
gra-901	54	22	indicating	indicate	VERB
gra-901	54	23	that	that	SCONJ
gra-901	54	24	certain	certain	ADJ
gra-901	54	25	ire1	ire1	ADJ
gra-901	54	26	activity	activity	NOUN
gra-901	54	27	may	may	AUX
gra-901	54	28	be	be	AUX
gra-901	54	29	necessary	necessary	ADJ
gra-901	54	30	to	to	PART
gra-901	54	31	maintain	maintain	VERB
gra-901	54	32	these	these	DET
gra-901	54	33	channels	channel	NOUN
gra-901	54	34	under	under	ADP
gra-901	54	35	physiological	physiological	ADJ
gra-901	54	36	conditions	condition	NOUN
gra-901	54	37	.	.	PUNCT
gra-901	55	1	inhibition	inhibition	NOUN
gra-901	55	2	of	of	ADP
gra-901	55	3	either	either	CCONJ
gra-901	55	4	perk	perk	NOUN
gra-901	55	5	or	or	CCONJ
gra-901	55	6	ire1	ire1	PROPN
gra-901	55	7	shows	show	VERB
gra-901	55	8	partial	partial	ADJ
gra-901	55	9	reversal	reversal	NOUN
gra-901	55	10	of	of	ADP
gra-901	55	11	electrical	electrical	ADJ
gra-901	55	12	remodeling	remodeling	NOUN
gra-901	55	13	,	,	PUNCT
gra-901	55	14	suggesting	suggest	VERB
gra-901	55	15	that	that	SCONJ
gra-901	55	16	the	the	DET
gra-901	55	17	atf6α	atf6α	PROPN
gra-901	55	18	arm	arm	NOUN
gra-901	55	19	may	may	AUX
gra-901	55	20	play	play	VERB
gra-901	55	21	a	a	DET
gra-901	55	22	role	role	NOUN
gra-901	55	23	in	in	ADP
gra-901	55	24	electrical	electrical	ADJ
gra-901	55	25	remodeling	remodeling	NOUN
gra-901	55	26	or	or	CCONJ
gra-901	55	27	that	that	SCONJ
gra-901	55	28	there	there	PRON
gra-901	55	29	are	be	VERB
gra-901	55	30	overlapping	overlap	VERB
gra-901	55	31	effects	effect	NOUN
gra-901	55	32	of	of	ADP
gra-901	55	33	the	the	DET
gra-901	55	34	upr	upr	NOUN
gra-901	55	35	arms	arm	NOUN
gra-901	55	36	.	.	PUNCT
gra-901	56	1	blocking	block	VERB
gra-901	56	2	upr	upr	ADJ
gra-901	56	3	activation	activation	NOUN
gra-901	56	4	can	can	AUX
gra-901	56	5	raise	raise	VERB
gra-901	56	6	ion	ion	NOUN
gra-901	56	7	channel	channel	NOUN
gra-901	56	8	levels	level	NOUN
gra-901	56	9	and	and	CCONJ
gra-901	56	10	may	may	AUX
gra-901	56	11	represent	represent	VERB
gra-901	56	12	a	a	DET
gra-901	56	13	new	new	ADJ
gra-901	56	14	and	and	CCONJ
gra-901	56	15	potentially	potentially	ADV
gra-901	56	16	fruitful	fruitful	ADJ
gra-901	56	17	antiarrhythmic	antiarrhythmic	ADJ
gra-901	56	18	paradigm	paradigm	NOUN
gra-901	56	19	.	.	PUNCT
gra-901	57	1	conclusion	conclusion	NOUN
gra-901	57	2	:	:	PUNCT
gra-901	57	3	unfolded	unfold	VERB
gra-901	57	4	protein	protein	NOUN
gra-901	57	5	response	response	NOUN
gra-901	57	6	plays	play	VERB
gra-901	57	7	a	a	DET
gra-901	57	8	vital	vital	ADJ
gra-901	57	9	role	role	NOUN
gra-901	57	10	in	in	ADP
gra-901	57	11	cardiovascular	cardiovascular	ADJ
gra-901	57	12	disease	disease	NOUN
gra-901	57	13	.	.	PUNCT
gra-901	58	1	it	it	PRON
gra-901	58	2	can	can	AUX
gra-901	58	3	be	be	AUX
gra-901	58	4	used	use	VERB
gra-901	58	5	as	as	ADP
gra-901	58	6	therapeutic	therapeutic	ADJ
gra-901	58	7	target	target	NOUN
gra-901	58	8	in	in	ADP
gra-901	58	9	future	future	NOUN
gra-901	58	10	to	to	PART
gra-901	58	11	treat	treat	VERB
gra-901	58	12	life	life	NOUN
gra-901	58	13	threatning	threatne	VERB
gra-901	58	14	conditions	condition	NOUN
gra-901	58	15	especially	especially	ADV
gra-901	58	16	arrhythmias	arrhythmia	NOUN
gra-901	58	17	.	.	PUNCT
gra-901	59	1	conflict	conflict	NOUN
gra-901	59	2	of	of	ADP
gra-901	59	3	interest	interest	NOUN
gra-901	59	4	:	:	PUNCT
gra-901	59	5	there	there	PRON
gra-901	59	6	is	be	VERB
gra-901	59	7	no	no	DET
gra-901	59	8	conict	conict	NOUN
gra-901	59	9	of	of	ADP
gra-901	59	10	interest	interest	NOUN
gra-901	59	11	.	.	PUNCT
gra-901	60	1	references	reference	NOUN
gra-901	60	2	:	:	PUNCT
gra-901	60	3	1	1	X
gra-901	60	4	.	.	X
gra-901	60	5	hammond	hammond	PROPN
gra-901	60	6	,	,	PUNCT
gra-901	60	7	c	c	X
gra-901	60	8	;	;	PUNCT
gra-901	60	9	braakman	braakman	NOUN
gra-901	60	10	,	,	PUNCT
gra-901	60	11	i	i	PRON
gra-901	60	12	;	;	PUNCT
gra-901	60	13	helenius	helenius	PROPN
gra-901	60	14	,	,	PUNCT
gra-901	60	15	a	a	DET
gra-901	60	16	."role	."role	NOUN
gra-901	60	17	of	of	ADP
gra-901	60	18	n	n	ADV
gra-901	60	19	-	-	PUNCT
gra-901	60	20	linked	link	VERB
gra-901	60	21	oligosaccharide	oligosaccharide	NOUN
gra-901	60	22	recognition	recognition	NOUN
gra-901	60	23	,	,	PUNCT
gra-901	60	24	glucose	glucose	NOUN
gra-901	60	25	trimming	trimming	NOUN
gra-901	60	26	,	,	PUNCT
gra-901	60	27	and	and	CCONJ
gra-901	60	28	calnexin	calnexin	ADV
gra-901	60	29	in	in	ADP
gra-901	60	30	glycoprotein	glycoprotein	NOUN
gra-901	60	31	folding	folding	NOUN
gra-901	60	32	and	and	CCONJ
gra-901	60	33	quality	quality	NOUN
gra-901	60	34	control	control	NOUN
gra-901	60	35	"	"	PUNCT
gra-901	60	36	.	.	PUNCT
gra-901	61	1	proceedings	proceeding	NOUN
gra-901	61	2	of	of	ADP
gra-901	61	3	the	the	DET
gra-901	61	4	national	national	PROPN
gra-901	61	5	academy	academy	PROPN
gra-901	61	6	of	of	ADP
gra-901	61	7	sciences	sciences	PROPN
gra-901	61	8	of	of	ADP
gra-901	61	9	the	the	DET
gra-901	61	10	united	united	PROPN
gra-901	61	11	states	states	PROPN
gra-901	61	12	of	of	ADP
gra-901	61	13	america.1994	america.1994	PROPN
gra-901	61	14	;	;	PUNCT
gra-901	61	15	91	91	NUM
gra-901	61	16	(	(	PUNCT
gra-901	61	17	3	3	NUM
gra-901	61	18	):	):	PUNCT
gra-901	61	19	913–7	913–7	NUM
gra-901	61	20	.	.	NOUN
gra-901	62	1	2	2	NUM
gra-901	62	2	.	.	X
gra-901	62	3	ron	ron	PROPN
gra-901	62	4	,	,	PUNCT
gra-901	62	5	d.	d.	PROPN
gra-901	62	6	;	;	PUNCT
gra-901	62	7	harding	harding	PROPN
gra-901	62	8	,	,	PUNCT
gra-901	62	9	h.	h.	PROPN
gra-901	62	10	p.	p.	PROPN
gra-901	62	11	;	;	PUNCT
gra-901	63	1	zhang	zhang	PROPN
gra-901	63	2	,	,	PUNCT
gra-901	63	3	y.	y.	PROPN
gra-901	63	4	"protein	"protein	PROPN
gra-901	63	5	translation	translation	NOUN
gra-901	63	6	and	and	CCONJ
gra-901	63	7	folding	folding	NOUN
gra-901	63	8	are	be	AUX
gra-901	63	9	coupled	couple	VERB
gra-901	63	10	by	by	ADP
gra-901	63	11	an	an	DET
gra-901	63	12	endoplasmic	endoplasmic	NOUN
gra-901	63	13	-	-	PUNCT
gra-901	63	14	reticulum	reticulum	NOUN
gra-901	63	15	-	-	PUNCT
gra-901	63	16	resident	resident	NOUN
gra-901	63	17	kinase	kinase	NOUN
gra-901	63	18	"	"	PUNCT
gra-901	63	19	.	.	PUNCT
gra-901	64	1	nature.1995	nature.1995	PROPN
gra-901	64	2	.	.	PROPN
gra-901	64	3	397	397	NUM
gra-901	64	4	(	(	PUNCT
gra-901	64	5	6716	6716	NUM
gra-901	64	6	):	):	PUNCT
gra-901	64	7	271–4	271–4	NOUN
gra-901	64	8	.	.	PUNCT
gra-901	65	1	3	3	NUM
gra-901	65	2	.	.	PUNCT
gra-901	65	3	.lee	.lee	PROPN
gra-901	65	4	,	,	PUNCT
gra-901	65	5	a.	a.	PROPN
gra-901	65	6	h.	h.	PROPN
gra-901	65	7	;	;	PUNCT
gra-901	65	8	iwakoshi	iwakoshi	PROPN
gra-901	65	9	,	,	PUNCT
gra-901	65	10	n.	n.	PROPN
gra-901	65	11	n.	n.	PROPN
gra-901	65	12	;	;	PUNCT
gra-901	65	13	anderson	anderson	PROPN
gra-901	65	14	,	,	PUNCT
gra-901	65	15	k.	k.	PROPN
gra-901	65	16	c.	c.	PROPN
gra-901	65	17	;	;	PUNCT
gra-901	65	18	glimcher	glimcher	NOUN
gra-901	65	19	,	,	PUNCT
gra-901	65	20	l.	l.	PROPN
gra-901	65	21	h.	h.	PROPN
gra-901	66	1	"	"	PUNCT
gra-901	66	2	proteasome	proteasome	NOUN
gra-901	66	3	inhibitors	inhibitor	NOUN
gra-901	66	4	disrupt	disrupt	VERB
gra-901	66	5	the	the	DET
gra-901	66	6	unfolded	unfolded	ADJ
gra-901	66	7	protein	protein	NOUN
gra-901	66	8	response	response	NOUN
gra-901	66	9	in	in	ADP
gra-901	66	10	myeloma	myeloma	PROPN
gra-901	66	11	cells	cell	NOUN
gra-901	66	12	"	"	PUNCT
gra-901	66	13	.	.	PUNCT
gra-901	67	1	proceedings	proceeding	NOUN
gra-901	67	2	of	of	ADP
gra-901	67	3	the	the	DET
gra-901	67	4	national	national	PROPN
gra-901	67	5	academy	academy	PROPN
gra-901	67	6	of	of	ADP
gra-901	67	7	sciences.2003	sciences.2003	PROPN
gra-901	67	8	;	;	PUNCT
gra-901	67	9	100	100	NUM
gra-901	67	10	(	(	PUNCT
gra-901	67	11	17	17	NUM
gra-901	67	12	):	):	PUNCT
gra-901	67	13	9946–51	9946–51	NOUN
gra-901	67	14	.	.	PUNCT
gra-901	68	1	4	4	X
gra-901	68	2	.	.	X
gra-901	68	3	lee	lee	PROPN
gra-901	68	4	,	,	PUNCT
gra-901	68	5	as	as	SCONJ
gra-901	68	6	trends	trend	NOUN
gra-901	68	7	biochem	biochem	VERB
gra-901	68	8	sci	sci	PROPN
gra-901	68	9	.1987;12	.1987;12	PROPN
gra-901	68	10	:	:	PUNCT
gra-901	68	11	20	20	NUM
gra-901	68	12	-	-	SYM
gra-901	68	13	23	23	NUM
gra-901	68	14	.	.	PUNCT
gra-901	69	1	5	5	NUM
gra-901	69	2	.	.	X
gra-901	69	3	.machamer	.machamer	PROPN
gra-901	69	4	,	,	PUNCT
gra-901	69	5	ce	ce	PROPN
gra-901	69	6	.	.	PROPN
gra-901	69	7	,	,	PUNCT
gra-901	69	8	doms	dom	NOUN
gra-901	69	9	,	,	PUNCT
gra-901	69	10	rw	rw	NOUN
gra-901	69	11	.	.	PROPN
gra-901	69	12	,	,	PUNCT
gra-901	69	13	bole	bole	PROPN
gra-901	69	14	,	,	PUNCT
gra-901	69	15	dg	dg	PROPN
gra-901	69	16	,	,	PUNCT
gra-901	69	17	.	.	PUNCT
gra-901	70	1	helenius	helenius	PROPN
gra-901	70	2	,	,	PUNCT
gra-901	70	3	a.	a.	NOUN
gra-901	70	4	,	,	PUNCT
gra-901	70	5	rose	rise	VERB
gra-901	70	6	,	,	PUNCT
gra-901	70	7	jk	jk	PROPN
gra-901	70	8	.	.	PUNCT
gra-901	71	1	j	j	PROPN
gra-901	71	2	biol	biol	PROPN
gra-901	71	3	chem	chem	NOUN
gra-901	71	4	1995;265	1995;265	NUM
gra-901	71	5	(	(	PUNCT
gra-901	71	6	12	12	NUM
gra-901	71	7	)	)	PUNCT
gra-901	71	8	6879	6879	NUM
gra-901	71	9	-	-	SYM
gra-901	71	10	6883	6883	NUM
gra-901	71	11	6	6	NUM
gra-901	71	12	.	.	PUNCT
gra-901	72	1	mccullough	mccullough	PROPN
gra-901	72	2	,	,	PUNCT
gra-901	72	3	k.	k.	PROPN
gra-901	72	4	,	,	PUNCT
gra-901	72	5	martindale	martindale	PROPN
gra-901	72	6	,	,	PUNCT
gra-901	72	7	j.	j.	PROPN
gra-901	72	8	,	,	PUNCT
gra-901	72	9	klotz	klotz	PROPN
gra-901	72	10	,	,	PUNCT
gra-901	72	11	l.	l.	PROPN
gra-901	72	12	,	,	PUNCT
gra-901	72	13	aw	aw	INTJ
gra-901	72	14	,	,	PUNCT
gra-901	72	15	t.	t.	PROPN
gra-901	72	16	,	,	PUNCT
gra-901	72	17	holbrook	holbrook	PROPN
gra-901	72	18	.	.	PUNCT
gra-901	73	1	mol	mol	ADP
gra-901	73	2	cell	cell	NOUN
gra-901	73	3	biol	biol	NOUN
gra-901	74	1	2001;21	2001;21	NUM
gra-901	74	2	:	:	PUNCT
gra-901	74	3	1249	1249	NUM
gra-901	74	4	-	-	SYM
gra-901	74	5	1259	1259	NUM
gra-901	74	6	.	.	PUNCT
gra-901	75	1	7	7	X
gra-901	75	2	.	.	X
gra-901	75	3	molinari	molinari	PROPN
gra-901	75	4	,	,	PUNCT
gra-901	75	5	m.	m.	NOUN
gra-901	75	6	,	,	PUNCT
gra-901	75	7	galli	galli	NOUN
gra-901	75	8	,	,	PUNCT
gra-901	75	9	c.	c.	NOUN
gra-901	75	10	,	,	PUNCT
gra-901	75	11	piccaluga	piccaluga	PROPN
gra-901	75	12	,	,	PUNCT
gra-901	75	13	v.	v.	PROPN
gra-901	75	14	,	,	PUNCT
gra-901	75	15	pieren	pieren	PROPN
gra-901	75	16	,	,	PUNCT
gra-901	75	17	m.	m.	NOUN
gra-901	75	18	,	,	PUNCT
gra-901	75	19	paganetti	paganetti	PROPN
gra-901	75	20	,	,	PUNCT
gra-901	75	21	p.	p.	PROPN
gra-901	75	22	)	)	PUNCT
gra-901	76	1	j	j	PROPN
gra-901	76	2	cell	cell	PROPN
gra-901	76	3	biol.2002	biol.2002	PROPN
gra-901	76	4	;	;	PUNCT
gra-901	76	5	158	158	NUM
gra-901	76	6	(	(	PUNCT
gra-901	76	7	2	2	NUM
gra-901	76	8	)	)	PUNCT
gra-901	76	9	247	247	NUM
gra-901	76	10	-	-	SYM
gra-901	76	11	257	257	NUM
gra-901	76	12	.	.	NOUN
gra-901	77	1	8	8	NUM
gra-901	77	2	.	.	X
gra-901	77	3	mori	mori	PROPN
gra-901	77	4	,	,	PUNCT
gra-901	77	5	k.	k.	PROPN
gra-901	77	6	,	,	PUNCT
gra-901	77	7	ogawa	ogawa	PROPN
gra-901	77	8	,	,	PUNCT
gra-901	77	9	o.	o.	PROPN
gra-901	77	10	,	,	PUNCT
gra-901	77	11	kawahara	kawahara	NOUN
gra-901	77	12	,	,	PUNCT
gra-901	77	13	t.	t.	PROPN
gra-901	77	14	,	,	PUNCT
gra-901	77	15	yanagi	yanagi	PROPN
gra-901	77	16	,	,	PUNCT
gra-901	77	17	h.	h.	PROPN
gra-901	77	18	,	,	PUNCT
gra-901	77	19	yura	yura	NOUN
gra-901	77	20	,	,	PUNCT
gra-901	77	21	t.	t.	PROPN
gra-901	77	22	(	(	PUNCT
gra-901	77	23	2000	2000	NUM
gra-901	77	24	)	)	PUNCT
gra-901	77	25	proc	proc	PROPN
gra-901	77	26	natl	natl	PROPN
gra-901	77	27	acad	acad	PROPN
gra-901	77	28	sci	sci	PROPN
gra-901	77	29	usa	usa	PROPN
gra-901	77	30	97	97	NUM
gra-901	77	31	4660	4660	NUM
gra-901	77	32	-	-	SYM
gra-901	77	33	4665	4665	NUM
gra-901	77	34	.	.	PUNCT
gra-901	78	1	9	9	X
gra-901	78	2	.	.	X
gra-901	78	3	urano	urano	PROPN
gra-901	78	4	,	,	PUNCT
gra-901	78	5	f	f	PROPN
gra-901	78	6	;	;	PUNCT
gra-901	78	7	wang	wang	PROPN
gra-901	78	8	,	,	PUNCT
gra-901	78	9	x	x	PRON
gra-901	78	10	;	;	PUNCT
gra-901	78	11	bertolotti	bertolotti	VERB
gra-901	78	12	,	,	PUNCT
gra-901	78	13	a	a	PRON
gra-901	78	14	;	;	PUNCT
gra-901	78	15	zhang	zhang	PROPN
gra-901	78	16	,	,	PUNCT
gra-901	78	17	y	y	PROPN
gra-901	78	18	;	;	PUNCT
gra-901	78	19	chung	chung	PROPN
gra-901	78	20	,	,	PUNCT
gra-901	78	21	p	p	X
gra-901	78	22	;	;	PUNCT
gra-901	78	23	harding	harding	PROPN
gra-901	78	24	,	,	PUNCT
gra-901	78	25	h.	h.	PROPN
gra-901	78	26	p.	p.	PROPN
gra-901	78	27	;	;	PUNCT
gra-901	78	28	ron	ron	PROPN
gra-901	78	29	,	,	PUNCT
gra-901	78	30	d	d	PROPN
gra-901	78	31	.	.	PUNCT
gra-901	79	1	"	"	PUNCT
gra-901	79	2	coupling	coupling	NOUN
gra-901	79	3	of	of	ADP
gra-901	79	4	stress	stress	NOUN
gra-901	79	5	in	in	ADP
gra-901	79	6	the	the	DET
gra-901	79	7	er	er	INTJ
gra-901	79	8	to	to	ADP
gra-901	79	9	activation	activation	NOUN
gra-901	79	10	of	of	ADP
gra-901	79	11	jnk	jnk	PROPN
gra-901	79	12	protein	protein	NOUN
gra-901	79	13	kinases	kinase	NOUN
gra-901	79	14	by	by	ADP
gra-901	79	15	transmembrane	transmembrane	ADJ
gra-901	79	16	protein	protein	NOUN
gra-901	79	17	kinase	kinase	PROPN
gra-901	79	18	ire1	ire1	PROPN
gra-901	79	19	"	"	PUNCT
gra-901	79	20	.	.	PUNCT
gra-901	80	1	science.2000	science.2000	PROPN
gra-901	80	2	;	;	PUNCT
gra-901	80	3	287	287	NUM
gra-901	80	4	(	(	PUNCT
gra-901	80	5	5453	5453	NUM
gra-901	80	6	):	):	PUNCT
gra-901	80	7	664–6	664–6	NUM
gra-901	80	8	.	.	PUNCT
gra-901	80	9	10	10	NUM
gra-901	80	10	.	.	PUNCT
gra-901	81	1	estibaliz	estibaliz	PROPN
gra-901	81	2	castillero	castillero	NOUN
gra-901	81	3	,	,	PUNCT
gra-901	81	4	hirokazu	hirokazu	PROPN
gra-901	81	5	akashi	akashi	PROPN
gra-901	81	6	,	,	PUNCT
gra-901	81	7	klara	klara	PROPN
gra-901	81	8	pendrak	pendrak	PROPN
gra-901	81	9	,	,	PUNCT
gra-901	81	10	halit	halit	PROPN
gra-901	81	11	yerebakan	yerebakan	PROPN
gra-901	81	12	,	,	PUNCT
gra-901	81	13	marc	marc	PROPN
gra-901	81	14	najjar	najjar	PROPN
gra-901	81	15	,	,	PUNCT
gra-901	81	16	catherine	catherine	PROPN
gra-901	81	17	wang	wang	PROPN
gra-901	81	18	.	.	PUNCT
gra-901	82	1	attenuation	attenuation	NOUN
gra-901	82	2	of	of	ADP
gra-901	82	3	the	the	DET
gra-901	82	4	unfolded	unfold	VERB
gra-901	82	5	protein	protein	NOUN
gra-901	82	6	response	response	NOUN
gra-901	82	7	and	and	CCONJ
gra-901	82	8	endoplasmic	endoplasmic	ADJ
gra-901	82	9	reticulum	reticulum	NOUN
gra-901	82	10	stress	stress	NOUN
gra-901	82	11	after	after	ADP
gra-901	82	12	mechanical	mechanical	ADJ
gra-901	82	13	unloading	unloading	NOUN
gra-901	82	14	in	in	ADP
gra-901	82	15	dilated	dilate	VERB
gra-901	82	16	cardiomyopathy	cardiomyopathy	ADJ
gra-901	82	17	am	be	AUX
gra-901	82	18	j	j	PROPN
gra-901	82	19	physiol	physiol	PROPN
gra-901	82	20	heart	heart	PROPN
gra-901	82	21	circ	circ	PROPN
gra-901	82	22	physiol.2015	physiol.2015	PROPN
gra-901	82	23	;	;	PUNCT
gra-901	82	24	309	309	NUM
gra-901	82	25	:	:	PUNCT
gra-901	82	26	h459	h459	PROPN
gra-901	82	27	–	–	PUNCT
gra-901	82	28	h470	h470	PROPN
gra-901	82	29	,	,	PUNCT
gra-901	82	30	2015	2015	NUM
gra-901	82	31	.	.	PUNCT
gra-901	83	1	11	11	NUM
gra-901	83	2	.	.	PUNCT
gra-901	84	1	sen	sen	PROPN
gra-901	84	2	s	s	PROPN
gra-901	84	3	,	,	PUNCT
gra-901	84	4	kundu	kundu	NOUN
gra-901	84	5	bk	bk	PROPN
gra-901	84	6	,	,	PUNCT
gra-901	84	7	wu	wu	PROPN
gra-901	84	8	hc	hc	PROPN
gra-901	84	9	,	,	PUNCT
gra-901	84	10	hashmi	hashmi	PROPN
gra-901	84	11	ss	ss	PROPN
gra-901	84	12	,	,	PUNCT
gra-901	84	13	guthrie	guthrie	PROPN
gra-901	84	14	p	p	PROPN
gra-901	84	15	,	,	PUNCT
gra-901	84	16	locke	locke	PROPN
gra-901	84	17	lw	lw	PROPN
gra-901	84	18	,	,	PUNCT
gra-901	84	19	roy	roy	PROPN
gra-901	84	20	rj	rj	PROPN
gra-901	84	21	,	,	PUNCT
gra-901	84	22	matherne	matherne	ADJ
gra-901	84	23	gp	gp	NOUN
gra-901	84	24	,	,	PUNCT
gra-901	84	25	berr	berr	PROPN
gra-901	84	26	ss	ss	PROPN
gra-901	84	27	,	,	PUNCT
gra-901	84	28	terwelp	terwelp	NOUN
gra-901	84	29	m	m	PROPN
gra-901	84	30	,	,	PUNCT
gra-901	84	31	scott	scott	PROPN
gra-901	84	32	b	b	PROPN
gra-901	84	33	,	,	PUNCT
gra-901	84	34	carranza	carranza	PROPN
gra-901	84	35	s	s	PROPN
gra-901	84	36	,	,	PUNCT
gra-901	84	37	frazier	frazier	PROPN
gra-901	85	1	oh	oh	INTJ
gra-901	85	2	,	,	PUNCT
gra-901	85	3	glover	glover	PROPN
gra-901	85	4	dk	dk	PROPN
gra-901	85	5	,	,	PUNCT
gra-901	85	6	dillmann	dillmann	PROPN
gra-901	85	7	wh	wh	PROPN
gra-901	85	8	,	,	PUNCT
gra-901	85	9	gambello	gambello	PROPN
gra-901	85	10	mj	mj	PROPN
gra-901	85	11	,	,	PUNCT
gra-901	85	12	entman	entman	NOUN
gra-901	85	13	ml	ml	PROPN
gra-901	85	14	,	,	PUNCT
gra-901	85	15	taegtmeyer	taegtmeyer	PROPN
gra-901	85	16	h.	h.	PROPN
gra-901	85	17	glucose	glucose	NOUN
gra-901	85	18	regulation	regulation	NOUN
gra-901	85	19	of	of	ADP
gra-901	85	20	loadinduced	loadinduced	ADJ
gra-901	85	21	mtor	mtor	NOUN
gra-901	85	22	signaling	signal	VERB
gra-901	85	23	and	and	CCONJ
gra-901	85	24	er	er	INTJ
gra-901	85	25	stress	stress	NOUN
gra-901	85	26	in	in	ADP
gra-901	85	27	mammalian	mammalian	ADJ
gra-901	85	28	heart	heart	NOUN
gra-901	85	29	.	.	PUNCT
gra-901	86	1	j	j	PROPN
gra-901	86	2	am	be	AUX
gra-901	86	3	heart	heart	NOUN
gra-901	86	4	assoc	assoc	PROPN
gra-901	86	5	2013;2	2013;2	NUM
gra-901	86	6	:	:	PUNCT
gra-901	86	7	e004796	e004796	NUM
gra-901	86	8	.	.	PUNCT
gra-901	87	1	12	12	NUM
gra-901	87	2	.	.	PUNCT
gra-901	88	1	liu	liu	PROPN
gra-901	88	2	m	m	PROPN
gra-901	88	3	,	,	PUNCT
gra-901	88	4	shi	shi	PROPN
gra-901	88	5	g	g	PROPN
gra-901	88	6	,	,	PUNCT
gra-901	88	7	zhou	zhou	PROPN
gra-901	88	8	a	a	X
gra-901	88	9	,	,	PUNCT
gra-901	88	10	et	et	PROPN
gra-901	88	11	al	al	PROPN
gra-901	88	12	.	.	PROPN
gra-901	89	1	activation	activation	NOUN
gra-901	89	2	of	of	ADP
gra-901	89	3	the	the	DET
gra-901	89	4	unfolded	unfold	VERB
gra-901	89	5	protein	protein	NOUN
gra-901	89	6	response	response	NOUN
gra-901	89	7	downregulates	downregulate	VERB
gra-901	89	8	cardiac	cardiac	ADJ
gra-901	89	9	ion	ion	NOUN
gra-901	89	10	channels	channel	NOUN
gra-901	89	11	in	in	ADP
gra-901	89	12	human	human	ADJ
gra-901	89	13	induced	induce	VERB
gra-901	89	14	pluripotent	pluripotent	ADJ
gra-901	89	15	stem	stem	NOUN
gra-901	89	16	cellderived	cellderive	VERB
gra-901	89	17	cardiomyocytes	cardiomyocyte	NOUN
gra-901	89	18	.	.	PUNCT
gra-901	90	1	j	j	PROPN
gra-901	90	2	mol	mol	PROPN
gra-901	90	3	cell	cell	NOUN
gra-901	90	4	cardiol	cardiol	NOUN
gra-901	90	5	.	.	PUNCT
gra-901	91	1	2018;117:62–71	2018;117:62–71	NUM
gra-901	91	2	.	.	PUNCT
gra-901	92	1	volume-8	volume-8	NUM
gra-901	92	2	,	,	PUNCT
gra-901	92	3	issue-12	issue-12	NOUN
gra-901	92	4	,	,	PUNCT
gra-901	92	5	december-2019	december-2019	ADJ
gra-901	92	6	•	•	NUM
gra-901	92	7	print	print	NOUN
gra-901	92	8	issn	issn	PROPN
gra-901	92	9	no	no	NOUN
gra-901	92	10	.	.	PROPN
gra-901	93	1	2277	2277	NUM
gra-901	93	2	8160	8160	NUM
gra-901	93	3	•	•	NOUN
gra-901	93	4	doi	doi	NOUN
gra-901	93	5	:	:	PUNCT
gra-901	93	6	10.36106	10.36106	NUM
gra-901	93	7	/	/	SYM
gra-901	93	8	gjra	gjra	NOUN
gra-901	93	9	x	x	SYM
gra-901	93	10	19gjra	19gjra	PROPN
gra-901	93	11	global	global	ADJ
gra-901	93	12	journal	journal	PROPN
gra-901	93	13	for	for	ADP
gra-901	93	14	research	research	NOUN
gra-901	93	15	analysis	analysis	NOUN