INTRODUCTION: Pregabalin is a structural similar drug of the inhibitory neurotransmitter γ-amino butyric acid but it is not functionally the same. It binds to the α-2-δ subunit of voltage-gated calcium channels reducing the release of several excitatory neurotransmitters and blocking the development of hyprealgesia and central sensitization. Opioids deals with acute pain and tricyclic antidepressants 1(TCAs) were used for chronic neuropathic conditions . Pregabalin binds to the α-2-δ subunit of voltage-gated calcium channels reducing the release of several excitatory neurotransmitters and blocking the development of 2hyprealgesia and central sensitization . Pregabalin has anticonvulsant anti-hyperalgesic and anxiolytic properties similar to gabapentin, but it has a more favorable pharmacokinetic prole including dose-independent 3absorption . Recently the role as oral pre-emptive analgesic of 4,5pregabalin for postoperative pain relief has been reviewed . This study puts in a effort to nd the efcacy of this drug in controlling the diabetic neuropathy pain. AIMS AND OBJECTIVES: To study the efcacy of pregabalin in post-operative. MATERIALS AND METHODS: This study was done in the Department of Department of General Surgery, PES Institute of Medical Sciences and Research, Kuppam This study was done using 60 patients. All were severely in pain according to pain numeric scale. They were given adjusted dose of pregabalin for 3 weeks and then they were checked for pain scores again and then reported. The study was done from July 2017 to June 2018. Inclusion Criteria 1. The patients were aged between 30-50 years Exclusion Criteria 1. Not consented patients Numeric Pain Scale was used: All the statistics were done using the SPSS software 2015 (California) RESULTS: Table 1: Age Distribution Table 2: Sex Distribution Table 3: Pain Scale initially Table 3: Pain Scale next day of adjusted dose use: Table 4: Unpaired t-Test DISCUSSION: Pregabalin has anticonvulsant anti-hyperalgesic and anxiolytic properties similar to gabapentin, but it has a more favorable pharmacokinetic prole including dose- 3independent absorption . Recently the role as oral pre- emptive analgesic of pregabalin for postoperative pain relief 4has been reviewed It is advantageous due to high efcacy with less drug doses and less chances of aspiration pneumonitis. Due to its limitations in the form of lesser control of block height & limited duration of analgesia researchers have used battery of drugs intrathecally like vasoconstrictors, (epinephrine) opioids, (fentanyl, buprenorphine) benzodiazepines, (midazolam) ketamine and many others as adjuvant to local anaesthetics to prolong the duration of sensory block & achieve longer 6,7perioperative analgesia . But each of this adjuvant has certain limitations of their own hence search for better options for acute postoperative analgesia research is still continuing. Provision of effective pain relief is a prerequisite accelerated convalescence. Previously the drugs used for acute & chronic pain were categorically different. Opioids, NSAIDS & local anaesthetics were tools for dealing with acute pain and tricyclic antidepressants (TCAs) were used for chronic neuropathic conditions. Two comparative studies gabapentin v/s pregabalin using single oral pre-emptive drug for infraumbilical surgeries under SAB, for evaluation of their comparative efcacy in terms of a cute postoperative analgesic benets with rescue analgesic as diclofenac have shown similar results to our 8,9study. A STUDY TO FIND THE EFFICACY OF PREGABALIN IN POST OPERATIVE PAIN Original Research Paper Dr Zamiruddin Ahmed Associate Professor, Department of General Surgery, PES Institute of Medical Sciences and Research, Kuppam General Surgery Pregabalin is a structural similar drug of the inhibitory neurotransmitter γ-amino butyric acid but it is not functionally the same. It binds to the α-2-δ subunit of voltage-gated calcium channels reducing the release of several excitatory neurotransmitters and blocking the development of hyprealgesia and central sensitization. This study puts in a effort to nd the efcacy of this drug in controlling the Post-operative pain. ABSTRACT KEYWORDS : Pregabalin, efcacy, analgesia, pain. VOLUME-8, ISSUE-10, OCTOBER-2019 • PRINT ISSN No. 2277 - 8160 • DOI : 10.36106/gjra 0 No Pain 1–3 Mild Pain (nagging, annoying, interfering little with ADLs) 4–6 Moderate Pain (interferes signicantly with ADLs) 7–10 Severe Pain (disabling; unable to perform ADLs) Number Mean age Std Deviation 60 67.27 years 17.48 years Number Male Female 60 49 11 Male Female Mild 41 9 Moderate 07 1 Severe 01 Nil Male Female Mild 07 03 Moderate Nil 01 Severe Nil Nil p-value Signicance Mild <0.05 Highly signicant Moderate <0.05 Highly signicant Severe >0.05 Not signicant 94 X GJRA - GLOBAL JOURNAL FOR RESEARCH ANALYSIS CONCLUSION: Pregabalin is very effective in controlling post operative pain. REFERENCES: 1. Shneker BF, McAuley JW. Pregabalin: A New Neuromodulator with broad therapeutic indications. Ann Pharmacother. 2005; 39: 2029-37. 2. Chizh BH, Gohring M, Troster A, Quartey GK, Schmelz M, Koppert W. Effects of oral pregabalin and operation on pain and central sensitization in the electrical hyperalgesia model in human volunteers. Br J Anaesth. 2007; 98: 246-54. 3. Guay DR. Pregabalin in neuropathic pain: A more „pharmacetically elegant „gabapentin? Am J Geriatr Pharmacother. 2005; 3: 274-87. 4. Frampton JE, Foster RH. Pregabalin: In the treatment of post herpetic neuralgia. Drugs2005; 65: 111-8; 9-20. 5. Gilron I. Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: Current evidence and future directions. Curr Opin Anaesthesiol 2007; 20: 456-72. 6. Sahu S, Sachan S, Verma A, Pandey HD, Chitra. Evaluation of Pregabalin for attenuation of postoperative pain in below umbilical surgeries under spinal anaesthesia. Anaesth Clin Pharmacol. 2010; 26 (2): 167-71. 7. Saraswat V, Arora V. Preemptive Gabapentin vs Pregabalin for Acute Postoperative Pain after Surgery under Spinal Anaesthesia. Ind J of Anaesth. 2008; 52 (6): 829-834. 8. Mathiesen O, Jacobsen LS, Holm HE, Randall S, Adamiec-Malmstroem L, Graungaard BK, Holst PE, Hilsted KL, Dahl JB. Pregabalin and dexamethasone for post-operative pain control: randomized controlled study in hip arthroplasty.Br J Anaesth. 2008 Oct; 101 (4): 535-41. 9. Tippana EM, Hamunen K, Kontinen VK, Kalso E. Do surgical patients benet from perioperative gabapentin/pregabalin? A systematic review of efcacy and safety. Anesth Analg. 2007; 104 (6): 1545-56. VOLUME-8, ISSUE-10, OCTOBER-2019 • PRINT ISSN No. 2277 - 8160 • DOI : 10.36106/gjra X 95GJRA - GLOBAL JOURNAL FOR RESEARCH ANALYSIS