id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
hls-12047	Zainul, Rahadian; Kharisma, Viol Dhea; Ciuputri, Pauline; Ansori, Arif Nur Muhammad; Herdiansyah, Mochammad Aqilah; Sahadewa, Sukma; Durry, Fara Disa	Antiretroviral activity from elderberry (Sambucus nigra L.) flowers against HIV-2 infection via reverse transcriptase inhibition: a viroinformatics study	2024	6	.pdf	application/pdf	4259	239	46	The predicted mechanism of HIV-2 RT inhibitors in this study refers to NNRTIs in HIV-1 by targeting a hydrophobic pocket for inhibition of polymerization reactions.37 In contrast to HIV-1, HIV-2 has mutations in RT with positions K65R, K70E, L74V, Q151M, M184I/V; RT mutations in HIV-2 trigger significant antiretroviral resistance compared to HIV-1.11 A more negative binding affinity value signifies a stronger influence produced by ligand binding on the target.34 Isohamnetin from elderberry (Sambucus nigra L.) flower extract is predicted to be a good antiretroviral candidate through inhibition of HIV-2 RT activity.	cache/hls-12047.pdf	txt/hls-12047.txt