id	sid	tid	token	lemma	pos
hls-12456	1	1	hrev_master	hrev_master	NOUN
hls-12456	1	2	healthcare	healthcare	NOUN
hls-12456	1	3	in	in	ADP
hls-12456	1	4	low	low	ADJ
hls-12456	1	5	-	-	PUNCT
hls-12456	1	6	resource	resource	NOUN
hls-12456	1	7	settings	setting	NOUN
hls-12456	1	8	2024	2024	NUM
hls-12456	1	9	;	;	PUNCT
hls-12456	1	10	volume	volume	NOUN
hls-12456	1	11	12(s2):12456	12(s2):12456	PROPN
hls-12456	1	12	the	the	DET
hls-12456	1	13	amount	amount	NOUN
hls-12456	1	14	of	of	ADP
hls-12456	1	15	dna	dna	NOUN
hls-12456	1	16	and	and	CCONJ
hls-12456	1	17	rna	rna	PROPN
hls-12456	1	18	in	in	ADP
hls-12456	1	19	primary	primary	ADJ
hls-12456	1	20	cancer	cancer	NOUN
hls-12456	1	21	cells	cell	NOUN
hls-12456	1	22	and	and	CCONJ
hls-12456	1	23	their	their	PRON
hls-12456	1	24	metastases	metastasis	NOUN
hls-12456	1	25	oleksandr	oleksandr	NOUN
hls-12456	1	26	herasymenko,1	herasymenko,1	NOUN
hls-12456	1	27	kostyantyn	kostyantyn	NOUN
hls-12456	1	28	gerasymenko,1	gerasymenko,1	NOUN
hls-12456	1	29	olha	olha	NOUN
hls-12456	1	30	herasymenko2	herasymenko2	NOUN
hls-12456	1	31	1department	1department	NUM
hls-12456	1	32	of	of	ADP
hls-12456	1	33	pathological	pathological	ADJ
hls-12456	1	34	anatomy	anatomy	NOUN
hls-12456	1	35	,	,	PUNCT
hls-12456	1	36	forensic	forensic	ADJ
hls-12456	1	37	medicine	medicine	NOUN
hls-12456	1	38	,	,	PUNCT
hls-12456	1	39	histology	histology	NOUN
hls-12456	1	40	,	,	PUNCT
hls-12456	1	41	donetsk	donetsk	ADJ
hls-12456	1	42	national	national	PROPN
hls-12456	1	43	medical	medical	PROPN
hls-12456	1	44	university	university	PROPN
hls-12456	1	45	,	,	PUNCT
hls-12456	1	46	kropyvnytskyi	kropyvnytskyi	PROPN
hls-12456	1	47	;	;	PUNCT
hls-12456	1	48	2feofaniya	2feofaniya	NUM
hls-12456	1	49	clinical	clinical	ADJ
hls-12456	1	50	hospital	hospital	NOUN
hls-12456	1	51	,	,	PUNCT
hls-12456	1	52	kyiv	kyiv	ADJ
hls-12456	1	53	,	,	PUNCT
hls-12456	1	54	ukraine	ukraine	ADJ
hls-12456	1	55	abstract	abstract	NOUN
hls-12456	1	56	considering	consider	VERB
hls-12456	1	57	the	the	DET
hls-12456	1	58	significant	significant	ADJ
hls-12456	1	59	impact	impact	NOUN
hls-12456	1	60	of	of	ADP
hls-12456	1	61	oncopathology	oncopathology	NOUN
hls-12456	1	62	on	on	ADP
hls-12456	1	63	global	global	ADJ
hls-12456	1	64	morbidity	morbidity	NOUN
hls-12456	1	65	and	and	CCONJ
hls-12456	1	66	mortality	mortality	NOUN
hls-12456	1	67	,	,	PUNCT
hls-12456	1	68	as	as	ADV
hls-12456	1	69	well	well	ADV
hls-12456	1	70	as	as	ADP
hls-12456	1	71	changes	change	NOUN
hls-12456	1	72	in	in	ADP
hls-12456	1	73	its	its	PRON
hls-12456	1	74	prevalence	prevalence	NOUN
hls-12456	1	75	and	and	CCONJ
hls-12456	1	76	typology	typology	NOUN
hls-12456	1	77	,	,	PUNCT
hls-12456	1	78	research	research	NOUN
hls-12456	1	79	into	into	ADP
hls-12456	1	80	the	the	DET
hls-12456	1	81	molecular	molecular	ADJ
hls-12456	1	82	-	-	PUNCT
hls-12456	1	83	genetic	genetic	ADJ
hls-12456	1	84	mechanisms	mechanism	NOUN
hls-12456	1	85	of	of	ADP
hls-12456	1	86	oncogenesis	oncogenesis	NOUN
hls-12456	1	87	and	and	CCONJ
hls-12456	1	88	metastasis	metastasis	NOUN
hls-12456	1	89	,	,	PUNCT
hls-12456	1	90	particularly	particularly	ADV
hls-12456	1	91	the	the	DET
hls-12456	1	92	role	role	NOUN
hls-12456	1	93	of	of	ADP
hls-12456	1	94	nucleic	nucleic	ADJ
hls-12456	1	95	acids	acid	NOUN
hls-12456	1	96	,	,	PUNCT
hls-12456	1	97	becomes	become	VERB
hls-12456	1	98	crucial	crucial	ADJ
hls-12456	1	99	.	.	PUNCT
hls-12456	2	1	the	the	DET
hls-12456	2	2	aim	aim	NOUN
hls-12456	2	3	of	of	ADP
hls-12456	2	4	this	this	DET
hls-12456	2	5	study	study	NOUN
hls-12456	2	6	is	be	AUX
hls-12456	2	7	to	to	PART
hls-12456	2	8	determine	determine	VERB
hls-12456	2	9	the	the	DET
hls-12456	2	10	content	content	NOUN
hls-12456	2	11	of	of	ADP
hls-12456	2	12	dna	dna	PROPN
hls-12456	2	13	and	and	CCONJ
hls-12456	2	14	rna	rna	NOUN
hls-12456	2	15	in	in	ADP
hls-12456	2	16	cells	cell	NOUN
hls-12456	2	17	of	of	ADP
hls-12456	2	18	primary	primary	ADJ
hls-12456	2	19	cancer	cancer	NOUN
hls-12456	2	20	and	and	CCONJ
hls-12456	2	21	its	its	PRON
hls-12456	2	22	metastases	metastasis	NOUN
hls-12456	2	23	through	through	ADP
hls-12456	2	24	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	2	25	analysis	analysis	NOUN
hls-12456	2	26	of	of	ADP
hls-12456	2	27	malignant	malignant	ADJ
hls-12456	2	28	cells	cell	NOUN
hls-12456	2	29	collected	collect	VERB
hls-12456	2	30	from	from	ADP
hls-12456	2	31	30	30	NUM
hls-12456	2	32	patients	patient	NOUN
hls-12456	2	33	with	with	ADP
hls-12456	2	34	primary	primary	ADJ
hls-12456	2	35	and	and	CCONJ
hls-12456	2	36	metastatic	metastatic	ADJ
hls-12456	2	37	oncological	oncological	ADJ
hls-12456	2	38	processes	process	NOUN
hls-12456	2	39	.	.	PUNCT
hls-12456	3	1	the	the	DET
hls-12456	3	2	following	follow	VERB
hls-12456	3	3	methods	method	NOUN
hls-12456	3	4	were	be	AUX
hls-12456	3	5	employed	employ	VERB
hls-12456	3	6	:	:	PUNCT
hls-12456	3	7	microspectrophotometric	microspectrophotometric	VERB
hls-12456	3	8	analysis	analysis	NOUN
hls-12456	3	9	using	use	VERB
hls-12456	3	10	the	the	DET
hls-12456	3	11	automated	automate	VERB
hls-12456	3	12	complex	complex	ADJ
hls-12456	3	13	“	"	PUNCT
hls-12456	3	14	protvapm11	protvapm11	NOUN
hls-12456	3	15	-	-	PUNCT
hls-12456	3	16	dvk-3	dvk-3	NOUN
hls-12456	3	17	m	m	NOUN
hls-12456	3	18	,	,	PUNCT
hls-12456	3	19	”	"	PUNCT
hls-12456	3	20	staining	stain	VERB
hls-12456	3	21	of	of	ADP
hls-12456	3	22	histological	histological	ADJ
hls-12456	3	23	specimens	specimen	NOUN
hls-12456	3	24	with	with	ADP
hls-12456	3	25	halo	halo	PROPN
hls-12456	3	26	cyanin	cyanin	NOUN
hls-12456	3	27	-	-	PUNCT
hls-12456	3	28	chrome	chrome	NOUN
hls-12456	3	29	alum	alum	NOUN
hls-12456	3	30	,	,	PUNCT
hls-12456	3	31	the	the	DET
hls-12456	3	32	discrete	discrete	ADJ
hls-12456	3	33	statistics	statistic	NOUN
hls-12456	3	34	method	method	NOUN
hls-12456	3	35	,	,	PUNCT
hls-12456	3	36	frequency	frequency	NOUN
hls-12456	3	37	and	and	CCONJ
hls-12456	3	38	cluster	cluster	NOUN
hls-12456	3	39	analysis	analysis	NOUN
hls-12456	3	40	,	,	PUNCT
hls-12456	3	41	and	and	CCONJ
hls-12456	3	42	the	the	DET
hls-12456	3	43	bibliographic	bibliographic	ADJ
hls-12456	3	44	method	method	NOUN
hls-12456	3	45	.	.	PUNCT
hls-12456	4	1	changes	change	NOUN
hls-12456	4	2	in	in	ADP
hls-12456	4	3	the	the	DET
hls-12456	4	4	concentration	concentration	NOUN
hls-12456	4	5	of	of	ADP
hls-12456	4	6	nucleic	nucleic	ADJ
hls-12456	4	7	acids	acid	NOUN
hls-12456	4	8	in	in	ADP
hls-12456	4	9	the	the	DET
hls-12456	4	10	cells	cell	NOUN
hls-12456	4	11	of	of	ADP
hls-12456	4	12	primary	primary	ADJ
hls-12456	4	13	and	and	CCONJ
hls-12456	4	14	metastatic	metastatic	ADJ
hls-12456	4	15	tumors	tumor	NOUN
hls-12456	4	16	were	be	AUX
hls-12456	4	17	identified	identify	VERB
hls-12456	4	18	during	during	ADP
hls-12456	4	19	the	the	DET
hls-12456	4	20	study	study	NOUN
hls-12456	4	21	.	.	PUNCT
hls-12456	5	1	the	the	DET
hls-12456	5	2	changes	change	NOUN
hls-12456	5	3	did	do	AUX
hls-12456	5	4	not	not	PART
hls-12456	5	5	always	always	ADV
hls-12456	5	6	correlate	correlate	VERB
hls-12456	5	7	with	with	ADP
hls-12456	5	8	each	each	DET
hls-12456	5	9	other	other	ADJ
hls-12456	5	10	,	,	PUNCT
hls-12456	5	11	indicating	indicate	VERB
hls-12456	5	12	morphofunctional	morphofunctional	ADJ
hls-12456	5	13	polymorphism	polymorphism	NOUN
hls-12456	5	14	in	in	ADP
hls-12456	5	15	tumor	tumor	NOUN
hls-12456	5	16	cell	cell	NOUN
hls-12456	5	17	populations	population	NOUN
hls-12456	5	18	.	.	PUNCT
hls-12456	6	1	a	a	DET
hls-12456	6	2	trend	trend	NOUN
hls-12456	6	3	towards	towards	ADP
hls-12456	6	4	a	a	DET
hls-12456	6	5	decrease	decrease	NOUN
hls-12456	6	6	in	in	ADP
hls-12456	6	7	nuclear	nuclear	ADJ
hls-12456	6	8	rna	rna	NOUN
hls-12456	6	9	concentration	concentration	NOUN
hls-12456	6	10	and	and	CCONJ
hls-12456	6	11	an	an	DET
hls-12456	6	12	increase	increase	NOUN
hls-12456	6	13	in	in	ADP
hls-12456	6	14	cytoplasmic	cytoplasmic	ADJ
hls-12456	6	15	rna	rna	NOUN
hls-12456	6	16	concentration	concentration	NOUN
hls-12456	6	17	in	in	ADP
hls-12456	6	18	metastases	metastasis	NOUN
hls-12456	6	19	were	be	AUX
hls-12456	6	20	observed	observe	VERB
hls-12456	6	21	,	,	PUNCT
hls-12456	6	22	suggesting	suggest	VERB
hls-12456	6	23	alterations	alteration	NOUN
hls-12456	6	24	in	in	ADP
hls-12456	6	25	metabolic	metabolic	NOUN
hls-12456	6	26	and	and	CCONJ
hls-12456	6	27	synthetic	synthetic	ADJ
hls-12456	6	28	processes	process	NOUN
hls-12456	6	29	in	in	ADP
hls-12456	6	30	cells	cell	NOUN
hls-12456	6	31	and	and	CCONJ
hls-12456	6	32	a	a	DET
hls-12456	6	33	decrease	decrease	NOUN
hls-12456	6	34	in	in	ADP
hls-12456	6	35	their	their	PRON
hls-12456	6	36	differentiation	differentiation	NOUN
hls-12456	6	37	degree	degree	NOUN
hls-12456	6	38	.	.	PUNCT
hls-12456	7	1	introduction	introduction	NOUN
hls-12456	7	2	molecular	molecular	ADJ
hls-12456	7	3	studies	study	NOUN
hls-12456	7	4	play	play	VERB
hls-12456	7	5	a	a	DET
hls-12456	7	6	key	key	ADJ
hls-12456	7	7	role	role	NOUN
hls-12456	7	8	in	in	ADP
hls-12456	7	9	the	the	DET
hls-12456	7	10	development	development	NOUN
hls-12456	7	11	of	of	ADP
hls-12456	7	12	modern	modern	ADJ
hls-12456	7	13	oncology	oncology	NOUN
hls-12456	7	14	as	as	ADP
hls-12456	7	15	a	a	DET
hls-12456	7	16	clinical	clinical	ADJ
hls-12456	7	17	discipline	discipline	NOUN
hls-12456	7	18	,	,	PUNCT
hls-12456	7	19	as	as	SCONJ
hls-12456	7	20	they	they	PRON
hls-12456	7	21	allow	allow	VERB
hls-12456	7	22	for	for	ADP
hls-12456	7	23	the	the	DET
hls-12456	7	24	uncovering	uncovering	NOUN
hls-12456	7	25	of	of	ADP
hls-12456	7	26	fundamental	fundamental	ADJ
hls-12456	7	27	mechanisms	mechanism	NOUN
hls-12456	7	28	of	of	ADP
hls-12456	7	29	the	the	DET
hls-12456	7	30	initiation	initiation	NOUN
hls-12456	7	31	and	and	CCONJ
hls-12456	7	32	progression	progression	NOUN
hls-12456	7	33	of	of	ADP
hls-12456	7	34	cancer	cancer	NOUN
hls-12456	7	35	at	at	ADP
hls-12456	7	36	the	the	DET
hls-12456	7	37	cellular	cellular	ADJ
hls-12456	7	38	and	and	CCONJ
hls-12456	7	39	molecular	molecular	ADJ
hls-12456	7	40	levels	level	NOUN
hls-12456	7	41	.	.	PUNCT
hls-12456	8	1	this	this	DET
hls-12456	8	2	knowledge	knowledge	NOUN
hls-12456	8	3	is	be	AUX
hls-12456	8	4	crucial	crucial	ADJ
hls-12456	8	5	for	for	ADP
hls-12456	8	6	developing	develop	VERB
hls-12456	8	7	new	new	ADJ
hls-12456	8	8	,	,	PUNCT
hls-12456	8	9	more	more	ADV
hls-12456	8	10	effective	effective	ADJ
hls-12456	8	11	treatment	treatment	NOUN
hls-12456	8	12	methods	method	NOUN
hls-12456	8	13	and	and	CCONJ
hls-12456	8	14	a	a	DET
hls-12456	8	15	personalized	personalized	ADJ
hls-12456	8	16	approach	approach	NOUN
hls-12456	8	17	to	to	ADP
hls-12456	8	18	each	each	DET
hls-12456	8	19	type	type	NOUN
hls-12456	8	20	of	of	ADP
hls-12456	8	21	oncopathology	oncopathology	NOUN
hls-12456	8	22	,	,	PUNCT
hls-12456	8	23	significantly	significantly	ADV
hls-12456	8	24	increasing	increase	VERB
hls-12456	8	25	the	the	DET
hls-12456	8	26	chances	chance	NOUN
hls-12456	8	27	of	of	ADP
hls-12456	8	28	successful	successful	ADJ
hls-12456	8	29	treatment	treatment	NOUN
hls-12456	8	30	and	and	CCONJ
hls-12456	8	31	improving	improve	VERB
hls-12456	8	32	the	the	DET
hls-12456	8	33	quality	quality	NOUN
hls-12456	8	34	of	of	ADP
hls-12456	8	35	life	life	NOUN
hls-12456	8	36	for	for	ADP
hls-12456	8	37	patients	patient	NOUN
hls-12456	8	38	.	.	PUNCT
hls-12456	9	1	rna	rna	PROPN
hls-12456	9	2	,	,	PUNCT
hls-12456	9	3	regardless	regardless	ADV
hls-12456	9	4	of	of	ADP
hls-12456	9	5	the	the	DET
hls-12456	9	6	state	state	NOUN
hls-12456	9	7	of	of	ADP
hls-12456	9	8	dna	dna	PROPN
hls-12456	9	9	,	,	PUNCT
hls-12456	9	10	can	can	AUX
hls-12456	9	11	independently	independently	ADV
hls-12456	9	12	influence	influence	VERB
hls-12456	9	13	the	the	DET
hls-12456	9	14	synthesis	synthesis	NOUN
hls-12456	9	15	and	and	CCONJ
hls-12456	9	16	structure	structure	NOUN
hls-12456	9	17	of	of	ADP
hls-12456	9	18	protein	protein	NOUN
hls-12456	9	19	compounds	compound	NOUN
hls-12456	9	20	.	.	PUNCT
hls-12456	10	1	in	in	ADP
hls-12456	10	2	the	the	DET
hls-12456	10	3	case	case	NOUN
hls-12456	10	4	of	of	ADP
hls-12456	10	5	oncological	oncological	ADJ
hls-12456	10	6	diseases	disease	NOUN
hls-12456	10	7	,	,	PUNCT
hls-12456	10	8	such	such	ADJ
hls-12456	10	9	changes	change	NOUN
hls-12456	10	10	often	often	ADV
hls-12456	10	11	lead	lead	VERB
hls-12456	10	12	to	to	ADP
hls-12456	10	13	a	a	DET
hls-12456	10	14	decrease	decrease	NOUN
hls-12456	10	15	in	in	ADP
hls-12456	10	16	the	the	DET
hls-12456	10	17	level	level	NOUN
hls-12456	10	18	of	of	ADP
hls-12456	10	19	proteins	protein	NOUN
hls-12456	10	20	responsible	responsible	ADJ
hls-12456	10	21	for	for	ADP
hls-12456	10	22	destroying	destroy	VERB
hls-12456	10	23	abnormal	abnormal	ADJ
hls-12456	10	24	cells	cell	NOUN
hls-12456	10	25	in	in	ADP
hls-12456	10	26	tumors	tumor	NOUN
hls-12456	10	27	.	.	PUNCT
hls-12456	11	1	at	at	ADP
hls-12456	11	2	the	the	DET
hls-12456	11	3	same	same	ADJ
hls-12456	11	4	time	time	NOUN
hls-12456	11	5	,	,	PUNCT
hls-12456	11	6	an	an	DET
hls-12456	11	7	increase	increase	NOUN
hls-12456	11	8	in	in	ADP
hls-12456	11	9	the	the	DET
hls-12456	11	10	concentration	concentration	NOUN
hls-12456	11	11	of	of	ADP
hls-12456	11	12	proteins	protein	NOUN
hls-12456	11	13	that	that	PRON
hls-12456	11	14	stimulate	stimulate	VERB
hls-12456	11	15	the	the	DET
hls-12456	11	16	division	division	NOUN
hls-12456	11	17	of	of	ADP
hls-12456	11	18	malignant	malignant	ADJ
hls-12456	11	19	cells	cell	NOUN
hls-12456	11	20	is	be	AUX
hls-12456	11	21	observed	observe	VERB
hls-12456	11	22	.	.	PUNCT
hls-12456	12	1	this	this	DET
hls-12456	12	2	issue	issue	NOUN
hls-12456	12	3	emphasizes	emphasize	VERB
hls-12456	12	4	the	the	DET
hls-12456	12	5	need	need	NOUN
hls-12456	12	6	to	to	PART
hls-12456	12	7	study	study	VERB
hls-12456	12	8	the	the	DET
hls-12456	12	9	interaction	interaction	NOUN
hls-12456	12	10	between	between	ADP
hls-12456	12	11	dna	dna	PROPN
hls-12456	12	12	and	and	CCONJ
hls-12456	12	13	rna	rna	PROPN
hls-12456	12	14	and	and	CCONJ
hls-12456	12	15	their	their	PRON
hls-12456	12	16	role	role	NOUN
hls-12456	12	17	in	in	ADP
hls-12456	12	18	the	the	DET
hls-12456	12	19	process	process	NOUN
hls-12456	12	20	of	of	ADP
hls-12456	12	21	oncogenesis	oncogenesis	NOUN
hls-12456	12	22	.	.	PUNCT
hls-12456	13	1	in	in	ADP
hls-12456	13	2	their	their	PRON
hls-12456	13	3	research	research	NOUN
hls-12456	13	4	,	,	PUNCT
hls-12456	13	5	sulaieva	sulaieva	PROPN
hls-12456	13	6	et	et	NOUN
hls-12456	13	7	al.1	al.1	PROPN
hls-12456	13	8	focused	focus	VERB
hls-12456	13	9	significantly	significantly	ADV
hls-12456	13	10	on	on	ADP
hls-12456	13	11	the	the	DET
hls-12456	13	12	perspective	perspective	NOUN
hls-12456	13	13	of	of	ADP
hls-12456	13	14	genetic	genetic	ADJ
hls-12456	13	15	studies	study	NOUN
hls-12456	13	16	in	in	ADP
hls-12456	13	17	modern	modern	ADJ
hls-12456	13	18	healthcare	healthcare	NOUN
hls-12456	13	19	.	.	PUNCT
hls-12456	14	1	they	they	PRON
hls-12456	14	2	examined	examine	VERB
hls-12456	14	3	the	the	DET
hls-12456	14	4	role	role	NOUN
hls-12456	14	5	of	of	ADP
hls-12456	14	6	genetic	genetic	ADJ
hls-12456	14	7	factors	factor	NOUN
hls-12456	14	8	in	in	ADP
hls-12456	14	9	the	the	DET
hls-12456	14	10	diagnosis	diagnosis	NOUN
hls-12456	14	11	and	and	CCONJ
hls-12456	14	12	treatment	treatment	NOUN
hls-12456	14	13	of	of	ADP
hls-12456	14	14	various	various	ADJ
hls-12456	14	15	diseases	disease	NOUN
hls-12456	14	16	,	,	PUNCT
hls-12456	14	17	emphasizing	emphasize	VERB
hls-12456	14	18	the	the	DET
hls-12456	14	19	importance	importance	NOUN
hls-12456	14	20	of	of	ADP
hls-12456	14	21	molecular	molecular	ADJ
hls-12456	14	22	-	-	PUNCT
hls-12456	14	23	biological	biological	ADJ
hls-12456	14	24	methods	method	NOUN
hls-12456	14	25	in	in	ADP
hls-12456	14	26	understanding	understand	VERB
hls-12456	14	27	the	the	DET
hls-12456	14	28	etiology	etiology	NOUN
hls-12456	14	29	and	and	CCONJ
hls-12456	14	30	pathogenesis	pathogenesis	NOUN
hls-12456	14	31	of	of	ADP
hls-12456	14	32	diseases	disease	NOUN
hls-12456	14	33	.	.	PUNCT
hls-12456	15	1	the	the	DET
hls-12456	15	2	authors	author	NOUN
hls-12456	15	3	also	also	ADV
hls-12456	15	4	emphasized	emphasize	VERB
hls-12456	15	5	the	the	DET
hls-12456	15	6	integration	integration	NOUN
hls-12456	15	7	of	of	ADP
hls-12456	15	8	genetic	genetic	ADJ
hls-12456	15	9	data	datum	NOUN
hls-12456	15	10	into	into	ADP
hls-12456	15	11	clinical	clinical	ADJ
hls-12456	15	12	practice	practice	NOUN
hls-12456	15	13	,	,	PUNCT
hls-12456	15	14	opening	open	VERB
hls-12456	15	15	new	new	ADJ
hls-12456	15	16	possibilities	possibility	NOUN
hls-12456	15	17	for	for	ADP
hls-12456	15	18	developing	develop	VERB
hls-12456	15	19	personalized	personalized	ADJ
hls-12456	15	20	approaches	approach	NOUN
hls-12456	15	21	to	to	ADP
hls-12456	15	22	treatment	treatment	NOUN
hls-12456	15	23	and	and	CCONJ
hls-12456	15	24	disease	disease	NOUN
hls-12456	15	25	prevention	prevention	NOUN
hls-12456	15	26	.	.	PUNCT
hls-12456	16	1	however	however	ADV
hls-12456	16	2	,	,	PUNCT
hls-12456	16	3	while	while	SCONJ
hls-12456	16	4	this	this	DET
hls-12456	16	5	study	study	NOUN
hls-12456	16	6	covered	cover	VERB
hls-12456	16	7	this	this	DET
hls-12456	16	8	important	important	ADJ
hls-12456	16	9	topic	topic	NOUN
hls-12456	16	10	,	,	PUNCT
hls-12456	16	11	the	the	DET
hls-12456	16	12	focus	focus	NOUN
hls-12456	16	13	was	be	AUX
hls-12456	16	14	shifted	shift	VERB
hls-12456	16	15	towards	towards	ADP
hls-12456	16	16	biobanking	biobanking	NOUN
hls-12456	16	17	,	,	PUNCT
hls-12456	16	18	leading	lead	VERB
hls-12456	16	19	to	to	ADP
hls-12456	16	20	insufficient	insufficient	ADJ
hls-12456	16	21	coverage	coverage	NOUN
hls-12456	16	22	of	of	ADP
hls-12456	16	23	the	the	DET
hls-12456	16	24	molecular	molecular	ADJ
hls-12456	16	25	mechanisms	mechanism	NOUN
hls-12456	16	26	of	of	ADP
hls-12456	16	27	oncogenesis	oncogenesis	NOUN
hls-12456	16	28	.	.	PUNCT
hls-12456	17	1	as	as	SCONJ
hls-12456	17	2	highlighted	highlight	VERB
hls-12456	17	3	in	in	ADP
hls-12456	17	4	the	the	DET
hls-12456	17	5	work	work	NOUN
hls-12456	17	6	of	of	ADP
hls-12456	17	7	bondarenko	bondarenko	PROPN
hls-12456	17	8	et	et	PROPN
hls-12456	17	9	al.2	al.2	PROPN
hls-12456	17	10	,	,	PUNCT
hls-12456	17	11	recent	recent	ADJ
hls-12456	17	12	research	research	NOUN
hls-12456	17	13	has	have	AUX
hls-12456	17	14	revealed	reveal	VERB
hls-12456	17	15	that	that	SCONJ
hls-12456	17	16	rna	rna	NOUN
hls-12456	17	17	-	-	PUNCT
hls-12456	17	18	binding	bind	VERB
hls-12456	17	19	proteins	protein	NOUN
hls-12456	17	20	play	play	VERB
hls-12456	17	21	a	a	DET
hls-12456	17	22	crucial	crucial	ADJ
hls-12456	17	23	role	role	NOUN
hls-12456	17	24	in	in	ADP
hls-12456	17	25	the	the	DET
hls-12456	17	26	spread	spread	NOUN
hls-12456	17	27	of	of	ADP
hls-12456	17	28	cancer	cancer	NOUN
hls-12456	17	29	.	.	PUNCT
hls-12456	18	1	these	these	DET
hls-12456	18	2	proteins	protein	NOUN
hls-12456	18	3	,	,	PUNCT
hls-12456	18	4	present	present	ADJ
hls-12456	18	5	in	in	ADP
hls-12456	18	6	all	all	DET
hls-12456	18	7	types	type	NOUN
hls-12456	18	8	of	of	ADP
hls-12456	18	9	cells	cell	NOUN
hls-12456	18	10	,	,	PUNCT
hls-12456	18	11	exhibit	exhibit	VERB
hls-12456	18	12	particular	particular	ADJ
hls-12456	18	13	activity	activity	NOUN
hls-12456	18	14	in	in	ADP
hls-12456	18	15	malignantly	malignantly	ADV
hls-12456	18	16	transformed	transform	VERB
hls-12456	18	17	cell	cell	NOUN
hls-12456	18	18	populations	population	NOUN
hls-12456	18	19	,	,	PUNCT
hls-12456	18	20	where	where	SCONJ
hls-12456	18	21	they	they	PRON
hls-12456	18	22	bind	bind	VERB
hls-12456	18	23	to	to	ADP
hls-12456	18	24	rna	rna	NOUN
hls-12456	18	25	molecules	molecule	NOUN
hls-12456	18	26	and	and	CCONJ
hls-12456	18	27	contribute	contribute	VERB
hls-12456	18	28	to	to	ADP
hls-12456	18	29	the	the	DET
hls-12456	18	30	acceleration	acceleration	NOUN
hls-12456	18	31	of	of	ADP
hls-12456	18	32	tumor	tumor	NOUN
hls-12456	18	33	growth	growth	NOUN
hls-12456	18	34	.	.	PUNCT
hls-12456	19	1	despite	despite	SCONJ
hls-12456	19	2	this	this	PRON
hls-12456	19	3	,	,	PUNCT
hls-12456	19	4	none	none	NOUN
hls-12456	19	5	of	of	ADP
hls-12456	19	6	the	the	DET
hls-12456	19	7	existing	exist	VERB
hls-12456	19	8	cancer	cancer	NOUN
hls-12456	19	9	treatment	treatment	NOUN
hls-12456	19	10	methods	method	NOUN
hls-12456	19	11	currently	currently	ADV
hls-12456	19	12	target	target	VERB
hls-12456	19	13	these	these	DET
hls-12456	19	14	proteins	protein	NOUN
hls-12456	19	15	,	,	PUNCT
hls-12456	19	16	underscoring	underscore	VERB
hls-12456	19	17	the	the	DET
hls-12456	19	18	need	need	NOUN
hls-12456	19	19	for	for	ADP
hls-12456	19	20	further	further	ADJ
hls-12456	19	21	research	research	NOUN
hls-12456	19	22	in	in	ADP
hls-12456	19	23	this	this	DET
hls-12456	19	24	direction	direction	NOUN
hls-12456	19	25	for	for	ADP
hls-12456	19	26	the	the	DET
hls-12456	19	27	development	development	NOUN
hls-12456	19	28	of	of	ADP
hls-12456	19	29	more	more	ADV
hls-12456	19	30	effective	effective	ADJ
hls-12456	19	31	treatments	treatment	NOUN
hls-12456	19	32	.	.	PUNCT
hls-12456	20	1	the	the	DET
hls-12456	20	2	study	study	NOUN
hls-12456	20	3	did	do	AUX
hls-12456	20	4	not	not	PART
hls-12456	20	5	adequately	adequately	ADV
hls-12456	20	6	address	address	VERB
hls-12456	20	7	the	the	DET
hls-12456	20	8	issues	issue	NOUN
hls-12456	20	9	of	of	ADP
hls-12456	20	10	oncodiagnosis	oncodiagnosis	NOUN
hls-12456	20	11	and	and	CCONJ
hls-12456	20	12	oncoprevention	oncoprevention	NOUN
hls-12456	20	13	.	.	PUNCT
hls-12456	21	1	correspondence	correspondence	NOUN
hls-12456	21	2	:	:	PUNCT
hls-12456	21	3	oleksandr	oleksandr	PROPN
hls-12456	21	4	herasymenko	herasymenko	PROPN
hls-12456	21	5	,	,	PUNCT
hls-12456	21	6	department	department	NOUN
hls-12456	21	7	of	of	ADP
hls-12456	21	8	pathological	pathological	ADJ
hls-12456	21	9	anatomy	anatomy	NOUN
hls-12456	21	10	,	,	PUNCT
hls-12456	21	11	forensic	forensic	ADJ
hls-12456	21	12	medicine	medicine	NOUN
hls-12456	21	13	,	,	PUNCT
hls-12456	21	14	histology	histology	NOUN
hls-12456	21	15	,	,	PUNCT
hls-12456	21	16	donetsk	donetsk	ADJ
hls-12456	21	17	national	national	PROPN
hls-12456	21	18	medical	medical	PROPN
hls-12456	21	19	university	university	PROPN
hls-12456	21	20	,	,	PUNCT
hls-12456	21	21	kropyvnytskyi	kropyvnytskyi	PROPN
hls-12456	21	22	,	,	PUNCT
hls-12456	21	23	ukraine	ukraine	NOUN
hls-12456	21	24	.	.	PUNCT
hls-12456	22	1	e	e	X
hls-12456	22	2	-	-	NOUN
hls-12456	22	3	mail	mail	NOUN
hls-12456	22	4	:	:	PUNCT
hls-12456	22	5	herasymenkool@ukr.net	herasymenkool@ukr.net	PROPN
hls-12456	22	6	key	key	ADJ
hls-12456	22	7	words	word	NOUN
hls-12456	22	8	:	:	PUNCT
hls-12456	22	9	carcinogenesis	carcinogenesis	NOUN
hls-12456	22	10	,	,	PUNCT
hls-12456	22	11	advanced	advanced	ADJ
hls-12456	22	12	molecular	molecular	ADJ
hls-12456	22	13	genetic	genetic	ADJ
hls-12456	22	14	analysis	analysis	NOUN
hls-12456	22	15	,	,	PUNCT
hls-12456	22	16	microspectrophotometry	microspectrophotometry	NOUN
hls-12456	22	17	,	,	PUNCT
hls-12456	22	18	nucleic	nucleic	ADJ
hls-12456	22	19	acids	acid	NOUN
hls-12456	22	20	,	,	PUNCT
hls-12456	22	21	oncodiagnosis	oncodiagnosis	NOUN
hls-12456	22	22	,	,	PUNCT
hls-12456	22	23	non	non	ADJ
hls-12456	22	24	-	-	ADJ
hls-12456	22	25	cell	cell	ADJ
hls-12456	22	26	autonomous	autonomous	ADJ
hls-12456	22	27	effectors	effector	NOUN
hls-12456	22	28	.	.	PUNCT
hls-12456	23	1	contributions	contribution	NOUN
hls-12456	23	2	:	:	PUNCT
hls-12456	24	1	oh	oh	INTJ
hls-12456	24	2	and	and	CCONJ
hls-12456	24	3	kg	kg	INTJ
hls-12456	24	4	,	,	PUNCT
hls-12456	24	5	conceptualization	conceptualization	NOUN
hls-12456	24	6	,	,	PUNCT
hls-12456	24	7	data	data	NOUN
hls-12456	24	8	curation	curation	NOUN
hls-12456	24	9	,	,	PUNCT
hls-12456	24	10	formal	formal	ADJ
hls-12456	24	11	analysis	analysis	NOUN
hls-12456	24	12	,	,	PUNCT
hls-12456	24	13	methodology	methodology	NOUN
hls-12456	24	14	,	,	PUNCT
hls-12456	24	15	validation	validation	NOUN
hls-12456	24	16	,	,	PUNCT
hls-12456	24	17	visualization	visualization	NOUN
hls-12456	24	18	,	,	PUNCT
hls-12456	24	19	writing	writing	NOUN
hls-12456	24	20	–	–	PUNCT
hls-12456	24	21	original	original	ADJ
hls-12456	24	22	draft	draft	NOUN
hls-12456	24	23	,	,	PUNCT
hls-12456	24	24	review	review	NOUN
hls-12456	24	25	and	and	CCONJ
hls-12456	24	26	editing	editing	NOUN
hls-12456	24	27	;	;	PUNCT
hls-12456	24	28	oh	oh	INTJ
hls-12456	24	29	,	,	PUNCT
hls-12456	24	30	conceptualization	conceptualization	NOUN
hls-12456	24	31	,	,	PUNCT
hls-12456	24	32	investigation	investigation	NOUN
hls-12456	24	33	,	,	PUNCT
hls-12456	24	34	methodology	methodology	NOUN
hls-12456	24	35	,	,	PUNCT
hls-12456	24	36	validation	validation	NOUN
hls-12456	24	37	,	,	PUNCT
hls-12456	24	38	and	and	CCONJ
hls-12456	24	39	writing	writing	NOUN
hls-12456	24	40	–	–	PUNCT
hls-12456	24	41	original	original	ADJ
hls-12456	24	42	draft	draft	NOUN
hls-12456	24	43	,	,	PUNCT
hls-12456	24	44	review	review	NOUN
hls-12456	24	45	and	and	CCONJ
hls-12456	24	46	editing	editing	NOUN
hls-12456	24	47	.	.	PUNCT
hls-12456	25	1	all	all	DET
hls-12456	25	2	the	the	DET
hls-12456	25	3	authors	author	NOUN
hls-12456	25	4	have	have	AUX
hls-12456	25	5	read	read	VERB
hls-12456	25	6	and	and	CCONJ
hls-12456	25	7	approved	approve	VERB
hls-12456	25	8	the	the	DET
hls-12456	25	9	final	final	ADJ
hls-12456	25	10	version	version	NOUN
hls-12456	25	11	of	of	ADP
hls-12456	25	12	the	the	DET
hls-12456	25	13	manuscript	manuscript	NOUN
hls-12456	25	14	and	and	CCONJ
hls-12456	25	15	agreed	agree	VERB
hls-12456	25	16	to	to	PART
hls-12456	25	17	be	be	AUX
hls-12456	25	18	held	hold	VERB
hls-12456	25	19	accountable	accountable	ADJ
hls-12456	25	20	for	for	ADP
hls-12456	25	21	all	all	DET
hls-12456	25	22	aspects	aspect	NOUN
hls-12456	25	23	of	of	ADP
hls-12456	25	24	the	the	DET
hls-12456	25	25	work	work	NOUN
hls-12456	25	26	.	.	PUNCT
hls-12456	26	1	conflict	conflict	NOUN
hls-12456	26	2	of	of	ADP
hls-12456	26	3	interest	interest	NOUN
hls-12456	26	4	:	:	PUNCT
hls-12456	26	5	the	the	DET
hls-12456	26	6	authors	author	NOUN
hls-12456	26	7	declare	declare	VERB
hls-12456	26	8	no	no	DET
hls-12456	26	9	potential	potential	ADJ
hls-12456	26	10	conflict	conflict	NOUN
hls-12456	26	11	of	of	ADP
hls-12456	26	12	interest	interest	NOUN
hls-12456	26	13	.	.	PUNCT
hls-12456	27	1	funding	funding	NOUN
hls-12456	27	2	:	:	PUNCT
hls-12456	27	3	none	none	NOUN
hls-12456	27	4	.	.	PUNCT
hls-12456	28	1	ethics	ethic	NOUN
hls-12456	28	2	approval	approval	NOUN
hls-12456	28	3	and	and	CCONJ
hls-12456	28	4	consent	consent	NOUN
hls-12456	28	5	to	to	PART
hls-12456	28	6	participate	participate	VERB
hls-12456	28	7	:	:	PUNCT
hls-12456	28	8	all	all	DET
hls-12456	28	9	procedures	procedure	NOUN
hls-12456	28	10	performed	perform	VERB
hls-12456	28	11	in	in	ADP
hls-12456	28	12	the	the	DET
hls-12456	28	13	study	study	NOUN
hls-12456	28	14	were	be	AUX
hls-12456	28	15	in	in	ADP
hls-12456	28	16	accordance	accordance	NOUN
hls-12456	28	17	with	with	ADP
hls-12456	28	18	the	the	DET
hls-12456	28	19	ethical	ethical	ADJ
hls-12456	28	20	standards	standard	NOUN
hls-12456	28	21	of	of	ADP
hls-12456	28	22	the	the	DET
hls-12456	28	23	institutional	institutional	ADJ
hls-12456	28	24	research	research	NOUN
hls-12456	28	25	committee	committee	NOUN
hls-12456	28	26	and	and	CCONJ
hls-12456	28	27	with	with	ADP
hls-12456	28	28	the	the	DET
hls-12456	28	29	1964	1964	NUM
hls-12456	28	30	helsinki	helsinki	PROPN
hls-12456	28	31	declaration	declaration	PROPN
hls-12456	28	32	and	and	CCONJ
hls-12456	28	33	its	its	PRON
hls-12456	28	34	later	later	ADJ
hls-12456	28	35	amendments	amendment	NOUN
hls-12456	28	36	.	.	PUNCT
hls-12456	29	1	patient	patient	ADJ
hls-12456	29	2	consent	consent	NOUN
hls-12456	29	3	for	for	ADP
hls-12456	29	4	publication	publication	NOUN
hls-12456	29	5	:	:	PUNCT
hls-12456	29	6	informed	inform	VERB
hls-12456	29	7	consent	consent	NOUN
hls-12456	29	8	was	be	AUX
hls-12456	29	9	obtained	obtain	VERB
hls-12456	29	10	from	from	ADP
hls-12456	29	11	all	all	DET
hls-12456	29	12	individuals	individual	NOUN
hls-12456	29	13	included	include	VERB
hls-12456	29	14	in	in	ADP
hls-12456	29	15	this	this	DET
hls-12456	29	16	study	study	NOUN
hls-12456	29	17	.	.	PUNCT
hls-12456	30	1	availability	availability	NOUN
hls-12456	30	2	of	of	ADP
hls-12456	30	3	data	datum	NOUN
hls-12456	30	4	and	and	CCONJ
hls-12456	30	5	materials	material	NOUN
hls-12456	30	6	:	:	PUNCT
hls-12456	30	7	the	the	DET
hls-12456	30	8	data	datum	NOUN
hls-12456	30	9	that	that	PRON
hls-12456	30	10	support	support	VERB
hls-12456	30	11	the	the	DET
hls-12456	30	12	findings	finding	NOUN
hls-12456	30	13	of	of	ADP
hls-12456	30	14	this	this	DET
hls-12456	30	15	study	study	NOUN
hls-12456	30	16	are	be	AUX
hls-12456	30	17	available	available	ADJ
hls-12456	30	18	on	on	ADP
hls-12456	30	19	request	request	NOUN
hls-12456	30	20	from	from	ADP
hls-12456	30	21	the	the	DET
hls-12456	30	22	corresponding	corresponding	ADJ
hls-12456	30	23	author	author	NOUN
hls-12456	30	24	.	.	PUNCT
hls-12456	31	1	received	receive	VERB
hls-12456	31	2	:	:	PUNCT
hls-12456	31	3	march	march	PROPN
hls-12456	31	4	2024	2024	NUM
hls-12456	31	5	.	.	PUNCT
hls-12456	32	1	accepted	accept	VERB
hls-12456	32	2	:	:	PUNCT
hls-12456	32	3	10	10	NUM
hls-12456	32	4	may	may	PROPN
hls-12456	32	5	2024	2024	NUM
hls-12456	32	6	.	.	PUNCT
hls-12456	33	1	early	early	ADJ
hls-12456	33	2	view	view	NOUN
hls-12456	33	3	:	:	PUNCT
hls-12456	33	4	22	22	NUM
hls-12456	33	5	august	august	PROPN
hls-12456	33	6	2024	2024	NUM
hls-12456	33	7	.	.	PUNCT
hls-12456	34	1	this	this	DET
hls-12456	34	2	work	work	NOUN
hls-12456	34	3	is	be	AUX
hls-12456	34	4	licensed	license	VERB
hls-12456	34	5	under	under	ADP
hls-12456	34	6	a	a	DET
hls-12456	34	7	creative	creative	ADJ
hls-12456	34	8	commons	common	NOUN
hls-12456	34	9	attribution	attribution	NOUN
hls-12456	34	10	4.0	4.0	NUM
hls-12456	34	11	license	license	NOUN
hls-12456	34	12	(	(	PUNCT
hls-12456	34	13	by	by	ADP
hls-12456	34	14	-	-	PUNCT
hls-12456	34	15	nc	nc	PROPN
hls-12456	34	16	4.0	4.0	NUM
hls-12456	34	17	)	)	PUNCT
hls-12456	34	18	.	.	PUNCT
hls-12456	35	1	©	©	PROPN
hls-12456	35	2	copyright	copyright	NOUN
hls-12456	35	3	:	:	PUNCT
hls-12456	35	4	the	the	DET
hls-12456	35	5	author(s	author(s	PROPN
hls-12456	35	6	)	)	PUNCT
hls-12456	35	7	,	,	PUNCT
hls-12456	35	8	2024	2024	NUM
hls-12456	35	9	licensee	licensee	NOUN
hls-12456	35	10	pagepress	pagepress	NOUN
hls-12456	35	11	,	,	PUNCT
hls-12456	35	12	italy	italy	PROPN
hls-12456	35	13	healthcare	healthcare	PROPN
hls-12456	35	14	in	in	ADP
hls-12456	35	15	low	low	ADJ
hls-12456	35	16	-	-	PUNCT
hls-12456	35	17	resource	resource	NOUN
hls-12456	35	18	settings	setting	NOUN
hls-12456	35	19	2024	2024	NUM
hls-12456	35	20	;	;	PUNCT
hls-12456	35	21	12(s2):12456	12(s2):12456	PROPN
hls-12456	35	22	doi:10.4081	doi:10.4081	NOUN
hls-12456	35	23	/	/	SYM
hls-12456	35	24	hls.2024.12456	hls.2024.12456	PROPN
hls-12456	35	25	publisher	publisher	NOUN
hls-12456	35	26	's	's	PART
hls-12456	35	27	note	note	NOUN
hls-12456	35	28	:	:	PUNCT
hls-12456	35	29	all	all	DET
hls-12456	35	30	claims	claim	NOUN
hls-12456	35	31	expressed	express	VERB
hls-12456	35	32	in	in	ADP
hls-12456	35	33	this	this	DET
hls-12456	35	34	article	article	NOUN
hls-12456	35	35	are	be	AUX
hls-12456	35	36	solely	solely	ADV
hls-12456	35	37	those	those	PRON
hls-12456	35	38	of	of	ADP
hls-12456	35	39	the	the	DET
hls-12456	35	40	authors	author	NOUN
hls-12456	35	41	and	and	CCONJ
hls-12456	35	42	do	do	AUX
hls-12456	35	43	not	not	PART
hls-12456	35	44	necessarily	necessarily	ADV
hls-12456	35	45	represent	represent	VERB
hls-12456	35	46	those	those	PRON
hls-12456	35	47	of	of	ADP
hls-12456	35	48	their	their	PRON
hls-12456	35	49	affiliated	affiliated	ADJ
hls-12456	35	50	organizations	organization	NOUN
hls-12456	35	51	,	,	PUNCT
hls-12456	35	52	or	or	CCONJ
hls-12456	35	53	those	those	PRON
hls-12456	35	54	of	of	ADP
hls-12456	35	55	the	the	DET
hls-12456	35	56	publisher	publisher	NOUN
hls-12456	35	57	,	,	PUNCT
hls-12456	35	58	the	the	DET
hls-12456	35	59	editors	editor	NOUN
hls-12456	35	60	and	and	CCONJ
hls-12456	35	61	the	the	DET
hls-12456	35	62	reviewers	reviewer	NOUN
hls-12456	35	63	.	.	PUNCT
hls-12456	36	1	any	any	DET
hls-12456	36	2	product	product	NOUN
hls-12456	36	3	that	that	PRON
hls-12456	36	4	may	may	AUX
hls-12456	36	5	be	be	AUX
hls-12456	36	6	evaluated	evaluate	VERB
hls-12456	36	7	in	in	ADP
hls-12456	36	8	this	this	DET
hls-12456	36	9	article	article	NOUN
hls-12456	36	10	or	or	CCONJ
hls-12456	36	11	claim	claim	NOUN
hls-12456	36	12	that	that	PRON
hls-12456	36	13	may	may	AUX
hls-12456	36	14	be	be	AUX
hls-12456	36	15	made	make	VERB
hls-12456	36	16	by	by	ADP
hls-12456	36	17	its	its	PRON
hls-12456	36	18	manufacturer	manufacturer	NOUN
hls-12456	36	19	is	be	AUX
hls-12456	36	20	not	not	PART
hls-12456	36	21	guaranteed	guarantee	VERB
hls-12456	36	22	or	or	CCONJ
hls-12456	36	23	endorsed	endorse	VERB
hls-12456	36	24	by	by	ADP
hls-12456	36	25	the	the	DET
hls-12456	36	26	publisher	publisher	NOUN
hls-12456	36	27	.	.	PUNCT
hls-12456	37	1	[	[	X
hls-12456	37	2	page	page	NOUN
hls-12456	37	3	76	76	NUM
hls-12456	37	4	]	]	PUNCT
hls-12456	38	1	[	[	X
hls-12456	38	2	healthcare	healthcare	NOUN
hls-12456	38	3	in	in	ADP
hls-12456	38	4	low	low	ADJ
hls-12456	38	5	-	-	PUNCT
hls-12456	38	6	resource	resource	NOUN
hls-12456	38	7	settings	setting	NOUN
hls-12456	38	8	2024;12(s2):12456	2024;12(s2):12456	NUM
hls-12456	38	9	]	]	X
hls-12456	38	10	non	non	ADJ
hls-12456	38	11	-co	-co	PROPN
hls-12456	38	12	mmerc	mmerc	PROPN
hls-12456	38	13	ial	ial	PROPN
hls-12456	38	14	us	us	PROPN
hls-12456	38	15	e	e	NOUN
hls-12456	38	16	o	o	X
hls-12456	38	17	nly	nly	ADV
hls-12456	38	18	in	in	ADP
hls-12456	38	19	their	their	PRON
hls-12456	38	20	exploration	exploration	NOUN
hls-12456	38	21	of	of	ADP
hls-12456	38	22	this	this	DET
hls-12456	38	23	topic	topic	NOUN
hls-12456	38	24	,	,	PUNCT
hls-12456	38	25	kirkilevskyi	kirkilevskyi	NOUN
hls-12456	38	26	et	et	NOUN
hls-12456	38	27	al.3	al.3	PROPN
hls-12456	38	28	elucidated	elucidate	VERB
hls-12456	38	29	the	the	DET
hls-12456	38	30	role	role	NOUN
hls-12456	38	31	of	of	ADP
hls-12456	38	32	rna	rna	NOUN
hls-12456	38	33	in	in	ADP
hls-12456	38	34	the	the	DET
hls-12456	38	35	formation	formation	NOUN
hls-12456	38	36	of	of	ADP
hls-12456	38	37	cancerous	cancerous	ADJ
hls-12456	38	38	tumors	tumor	NOUN
hls-12456	38	39	and	and	CCONJ
hls-12456	38	40	explained	explain	VERB
hls-12456	38	41	the	the	DET
hls-12456	38	42	reasons	reason	NOUN
hls-12456	38	43	for	for	ADP
hls-12456	38	44	their	their	PRON
hls-12456	38	45	insensitivity	insensitivity	NOUN
hls-12456	38	46	to	to	ADP
hls-12456	38	47	therapy	therapy	NOUN
hls-12456	38	48	.	.	PUNCT
hls-12456	39	1	to	to	PART
hls-12456	39	2	comprehend	comprehend	VERB
hls-12456	39	3	the	the	DET
hls-12456	39	4	causes	cause	NOUN
hls-12456	39	5	of	of	ADP
hls-12456	39	6	neoplasia	neoplasia	NOUN
hls-12456	39	7	and	and	CCONJ
hls-12456	39	8	optimize	optimize	VERB
hls-12456	39	9	the	the	DET
hls-12456	39	10	process	process	NOUN
hls-12456	39	11	of	of	ADP
hls-12456	39	12	its	its	PRON
hls-12456	39	13	treatment	treatment	NOUN
hls-12456	39	14	,	,	PUNCT
hls-12456	39	15	patients	patient	NOUN
hls-12456	39	16	must	must	AUX
hls-12456	39	17	undergo	undergo	VERB
hls-12456	39	18	a	a	DET
hls-12456	39	19	series	series	NOUN
hls-12456	39	20	of	of	ADP
hls-12456	39	21	investigations	investigation	NOUN
hls-12456	39	22	.	.	PUNCT
hls-12456	40	1	the	the	DET
hls-12456	40	2	most	most	ADV
hls-12456	40	3	effective	effective	ADJ
hls-12456	40	4	method	method	NOUN
hls-12456	40	5	turned	turn	VERB
hls-12456	40	6	out	out	ADP
hls-12456	40	7	to	to	PART
hls-12456	40	8	be	be	AUX
hls-12456	40	9	an	an	DET
hls-12456	40	10	extended	extended	ADJ
hls-12456	40	11	molecular	molecular	ADJ
hls-12456	40	12	-	-	PUNCT
hls-12456	40	13	genetic	genetic	ADJ
hls-12456	40	14	analysis	analysis	NOUN
hls-12456	40	15	of	of	ADP
hls-12456	40	16	tumors	tumor	NOUN
hls-12456	40	17	.	.	PUNCT
hls-12456	41	1	the	the	DET
hls-12456	41	2	application	application	NOUN
hls-12456	41	3	of	of	ADP
hls-12456	41	4	this	this	DET
hls-12456	41	5	method	method	NOUN
hls-12456	41	6	allows	allow	VERB
hls-12456	41	7	for	for	ADP
hls-12456	41	8	the	the	DET
hls-12456	41	9	construction	construction	NOUN
hls-12456	41	10	of	of	ADP
hls-12456	41	11	the	the	DET
hls-12456	41	12	most	most	ADV
hls-12456	41	13	optimal	optimal	ADJ
hls-12456	41	14	treatment	treatment	NOUN
hls-12456	41	15	schemes	scheme	NOUN
hls-12456	41	16	for	for	ADP
hls-12456	41	17	cancer	cancer	NOUN
hls-12456	41	18	patients	patient	NOUN
hls-12456	41	19	,	,	PUNCT
hls-12456	41	20	achieving	achieve	VERB
hls-12456	41	21	maximum	maximum	ADJ
hls-12456	41	22	efficacy	efficacy	NOUN
hls-12456	41	23	with	with	ADP
hls-12456	41	24	minimal	minimal	ADJ
hls-12456	41	25	chemotherapy	chemotherapy	NOUN
hls-12456	41	26	toxicity	toxicity	NOUN
hls-12456	41	27	.	.	PUNCT
hls-12456	42	1	despite	despite	SCONJ
hls-12456	42	2	the	the	DET
hls-12456	42	3	comprehensive	comprehensive	ADJ
hls-12456	42	4	data	datum	NOUN
hls-12456	42	5	on	on	ADP
hls-12456	42	6	gastrointestinal	gastrointestinal	ADJ
hls-12456	42	7	oncopathology	oncopathology	NOUN
hls-12456	42	8	,	,	PUNCT
hls-12456	42	9	this	this	DET
hls-12456	42	10	study	study	NOUN
hls-12456	42	11	requires	require	VERB
hls-12456	42	12	additional	additional	ADJ
hls-12456	42	13	clarification	clarification	NOUN
hls-12456	42	14	regarding	regard	VERB
hls-12456	42	15	tumors	tumor	NOUN
hls-12456	42	16	in	in	ADP
hls-12456	42	17	other	other	ADJ
hls-12456	42	18	organs	organ	NOUN
hls-12456	42	19	and	and	CCONJ
hls-12456	42	20	systems	system	NOUN
hls-12456	42	21	.	.	PUNCT
hls-12456	43	1	in	in	ADP
hls-12456	43	2	their	their	PRON
hls-12456	43	3	study	study	NOUN
hls-12456	43	4	,	,	PUNCT
hls-12456	43	5	dumanskyi	dumanskyi	NOUN
hls-12456	43	6	et	et	PROPN
hls-12456	43	7	al.4	al.4	PROPN
hls-12456	43	8	identified	identify	VERB
hls-12456	43	9	that	that	SCONJ
hls-12456	43	10	the	the	DET
hls-12456	43	11	molecular	molecular	ADJ
hls-12456	43	12	phenotype	phenotype	NOUN
hls-12456	43	13	of	of	ADP
hls-12456	43	14	a	a	DET
hls-12456	43	15	tumor	tumor	NOUN
hls-12456	43	16	population	population	NOUN
hls-12456	43	17	largely	largely	ADV
hls-12456	43	18	determines	determine	VERB
hls-12456	43	19	its	its	PRON
hls-12456	43	20	sensitivity	sensitivity	NOUN
hls-12456	43	21	to	to	ADP
hls-12456	43	22	radiation	radiation	NOUN
hls-12456	43	23	therapy	therapy	NOUN
hls-12456	43	24	.	.	PUNCT
hls-12456	44	1	the	the	DET
hls-12456	44	2	researchers	researcher	NOUN
hls-12456	44	3	emphasized	emphasize	VERB
hls-12456	44	4	the	the	DET
hls-12456	44	5	prospect	prospect	NOUN
hls-12456	44	6	of	of	ADP
hls-12456	44	7	molecular	molecular	ADJ
hls-12456	44	8	-	-	PUNCT
hls-12456	44	9	genetic	genetic	ADJ
hls-12456	44	10	analysis	analysis	NOUN
hls-12456	44	11	as	as	ADP
hls-12456	44	12	a	a	DET
hls-12456	44	13	leading	lead	VERB
hls-12456	44	14	method	method	NOUN
hls-12456	44	15	for	for	ADP
hls-12456	44	16	optimizing	optimize	VERB
hls-12456	44	17	treatment	treatment	NOUN
hls-12456	44	18	planning	planning	NOUN
hls-12456	44	19	.	.	PUNCT
hls-12456	45	1	however	however	ADV
hls-12456	45	2	,	,	PUNCT
hls-12456	45	3	the	the	DET
hls-12456	45	4	theme	theme	NOUN
hls-12456	45	5	of	of	ADP
hls-12456	45	6	metastasis	metastasis	NOUN
hls-12456	45	7	and	and	CCONJ
hls-12456	45	8	its	its	PRON
hls-12456	45	9	prevention	prevention	NOUN
hls-12456	45	10	was	be	AUX
hls-12456	45	11	insufficiently	insufficiently	ADV
hls-12456	45	12	addressed	address	VERB
hls-12456	45	13	,	,	PUNCT
hls-12456	45	14	requiring	require	VERB
hls-12456	45	15	further	further	ADJ
hls-12456	45	16	clarification	clarification	NOUN
hls-12456	45	17	.	.	PUNCT
hls-12456	46	1	kulak5	kulak5	PROPN
hls-12456	46	2	discussed	discuss	VERB
hls-12456	46	3	the	the	DET
hls-12456	46	4	prospect	prospect	NOUN
hls-12456	46	5	of	of	ADP
hls-12456	46	6	influencing	influence	VERB
hls-12456	46	7	molecular	molecular	ADJ
hls-12456	46	8	-	-	PUNCT
hls-12456	46	9	genetic	genetic	ADJ
hls-12456	46	10	mechanisms	mechanism	NOUN
hls-12456	46	11	during	during	ADP
hls-12456	46	12	the	the	DET
hls-12456	46	13	treatment	treatment	NOUN
hls-12456	46	14	of	of	ADP
hls-12456	46	15	oncological	oncological	ADJ
hls-12456	46	16	diseases	disease	NOUN
hls-12456	46	17	.	.	PUNCT
hls-12456	47	1	the	the	DET
hls-12456	47	2	author	author	NOUN
hls-12456	47	3	emphasized	emphasize	VERB
hls-12456	47	4	the	the	DET
hls-12456	47	5	therapeutic	therapeutic	ADJ
hls-12456	47	6	modality	modality	NOUN
hls-12456	47	7	of	of	ADP
hls-12456	47	8	mrna	mrna	PROPN
hls-12456	47	9	as	as	ADP
hls-12456	47	10	a	a	DET
hls-12456	47	11	target	target	NOUN
hls-12456	47	12	for	for	ADP
hls-12456	47	13	developing	develop	VERB
hls-12456	47	14	chemotherapeutic	chemotherapeutic	ADJ
hls-12456	47	15	agents	agent	NOUN
hls-12456	47	16	.	.	PUNCT
hls-12456	48	1	despite	despite	SCONJ
hls-12456	48	2	the	the	DET
hls-12456	48	3	significant	significant	ADJ
hls-12456	48	4	potential	potential	NOUN
hls-12456	48	5	in	in	ADP
hls-12456	48	6	this	this	DET
hls-12456	48	7	field	field	NOUN
hls-12456	48	8	,	,	PUNCT
hls-12456	48	9	developments	development	NOUN
hls-12456	48	10	within	within	ADP
hls-12456	48	11	it	it	PRON
hls-12456	48	12	face	face	VERB
hls-12456	48	13	considerable	considerable	ADJ
hls-12456	48	14	challenges	challenge	NOUN
hls-12456	48	15	,	,	PUNCT
hls-12456	48	16	leading	lead	VERB
hls-12456	48	17	to	to	ADP
hls-12456	48	18	only	only	ADV
hls-12456	48	19	a	a	DET
hls-12456	48	20	few	few	ADJ
hls-12456	48	21	projects	project	NOUN
hls-12456	48	22	reaching	reach	VERB
hls-12456	48	23	the	the	DET
hls-12456	48	24	stage	stage	NOUN
hls-12456	48	25	of	of	ADP
hls-12456	48	26	clinical	clinical	ADJ
hls-12456	48	27	trials	trial	NOUN
hls-12456	48	28	.	.	PUNCT
hls-12456	49	1	despite	despite	SCONJ
hls-12456	49	2	a	a	DET
hls-12456	49	3	detailed	detailed	ADJ
hls-12456	49	4	examination	examination	NOUN
hls-12456	49	5	of	of	ADP
hls-12456	49	6	the	the	DET
hls-12456	49	7	application	application	NOUN
hls-12456	49	8	of	of	ADP
hls-12456	49	9	rna	rna	NOUN
hls-12456	49	10	interference	interference	NOUN
hls-12456	49	11	methods	method	NOUN
hls-12456	49	12	,	,	PUNCT
hls-12456	49	13	the	the	DET
hls-12456	49	14	issue	issue	NOUN
hls-12456	49	15	of	of	ADP
hls-12456	49	16	diagnosis	diagnosis	NOUN
hls-12456	49	17	and	and	CCONJ
hls-12456	49	18	prevention	prevention	NOUN
hls-12456	49	19	at	at	ADP
hls-12456	49	20	the	the	DET
hls-12456	49	21	molecular	molecular	ADJ
hls-12456	49	22	-	-	PUNCT
hls-12456	49	23	genetic	genetic	ADJ
hls-12456	49	24	level	level	NOUN
hls-12456	49	25	was	be	AUX
hls-12456	49	26	not	not	PART
hls-12456	49	27	adequately	adequately	ADV
hls-12456	49	28	addressed	address	VERB
hls-12456	49	29	in	in	ADP
hls-12456	49	30	this	this	DET
hls-12456	49	31	study	study	NOUN
hls-12456	49	32	.	.	PUNCT
hls-12456	50	1	thus	thus	ADV
hls-12456	50	2	,	,	PUNCT
hls-12456	50	3	considering	consider	VERB
hls-12456	50	4	the	the	DET
hls-12456	50	5	increase	increase	NOUN
hls-12456	50	6	in	in	ADP
hls-12456	50	7	atypia	atypia	PROPN
hls-12456	50	8	,	,	PUNCT
hls-12456	50	9	polymorphism	polymorphism	NOUN
hls-12456	50	10	,	,	PUNCT
hls-12456	50	11	and	and	CCONJ
hls-12456	50	12	changes	change	NOUN
hls-12456	50	13	in	in	ADP
hls-12456	50	14	nuclear	nuclear	ADJ
hls-12456	50	15	-	-	PUNCT
hls-12456	50	16	cytoplasmic	cytoplasmic	ADJ
hls-12456	50	17	ratio	ratio	NOUN
hls-12456	50	18	,	,	PUNCT
hls-12456	50	19	alongside	alongside	ADP
hls-12456	50	20	the	the	DET
hls-12456	50	21	significant	significant	ADJ
hls-12456	50	22	feature	feature	NOUN
hls-12456	50	23	of	of	ADP
hls-12456	50	24	tumor	tumor	NOUN
hls-12456	50	25	growth	growth	NOUN
hls-12456	50	26	being	be	AUX
hls-12456	50	27	the	the	DET
hls-12456	50	28	alteration	alteration	NOUN
hls-12456	50	29	of	of	ADP
hls-12456	50	30	dna	dna	PROPN
hls-12456	50	31	and	and	CCONJ
hls-12456	50	32	rna	rna	NOUN
hls-12456	50	33	levels	level	NOUN
hls-12456	50	34	,	,	PUNCT
hls-12456	50	35	the	the	DET
hls-12456	50	36	goal	goal	NOUN
hls-12456	50	37	of	of	ADP
hls-12456	50	38	the	the	DET
hls-12456	50	39	research	research	NOUN
hls-12456	50	40	is	be	AUX
hls-12456	50	41	to	to	PART
hls-12456	50	42	determine	determine	VERB
hls-12456	50	43	dna	dna	PROPN
hls-12456	50	44	and	and	CCONJ
hls-12456	50	45	rna	rna	PROPN
hls-12456	50	46	in	in	ADP
hls-12456	50	47	cells	cell	NOUN
hls-12456	50	48	of	of	ADP
hls-12456	50	49	the	the	DET
hls-12456	50	50	primary	primary	ADJ
hls-12456	50	51	tumor	tumor	NOUN
hls-12456	50	52	and	and	CCONJ
hls-12456	50	53	its	its	PRON
hls-12456	50	54	metastases	metastasis	NOUN
hls-12456	50	55	.	.	PUNCT
hls-12456	51	1	this	this	PRON
hls-12456	51	2	will	will	AUX
hls-12456	51	3	help	help	VERB
hls-12456	51	4	understand	understand	VERB
hls-12456	51	5	the	the	DET
hls-12456	51	6	mechanism	mechanism	NOUN
hls-12456	51	7	of	of	ADP
hls-12456	51	8	metastasis	metastasis	NOUN
hls-12456	51	9	development	development	NOUN
hls-12456	51	10	and	and	CCONJ
hls-12456	51	11	develop	develop	VERB
hls-12456	51	12	measures	measure	NOUN
hls-12456	51	13	to	to	PART
hls-12456	51	14	prevent	prevent	VERB
hls-12456	51	15	metastasis	metastasis	NOUN
hls-12456	51	16	.	.	PUNCT
hls-12456	52	1	materials	material	NOUN
hls-12456	52	2	and	and	CCONJ
hls-12456	52	3	methods	method	NOUN
hls-12456	52	4	during	during	ADP
hls-12456	52	5	the	the	DET
hls-12456	52	6	research	research	NOUN
hls-12456	52	7	,	,	PUNCT
hls-12456	52	8	the	the	DET
hls-12456	52	9	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	52	10	analysis	analysis	NOUN
hls-12456	52	11	method	method	NOUN
hls-12456	52	12	was	be	AUX
hls-12456	52	13	primarily	primarily	ADV
hls-12456	52	14	utilized	utilize	VERB
hls-12456	52	15	.	.	PUNCT
hls-12456	53	1	this	this	DET
hls-12456	53	2	method	method	NOUN
hls-12456	53	3	was	be	AUX
hls-12456	53	4	employed	employ	VERB
hls-12456	53	5	to	to	PART
hls-12456	53	6	determine	determine	VERB
hls-12456	53	7	the	the	DET
hls-12456	53	8	levels	level	NOUN
hls-12456	53	9	of	of	ADP
hls-12456	53	10	dna	dna	PROPN
hls-12456	53	11	and	and	CCONJ
hls-12456	53	12	rna	rna	NOUN
hls-12456	53	13	in	in	ADP
hls-12456	53	14	colonies	colony	NOUN
hls-12456	53	15	of	of	ADP
hls-12456	53	16	primary	primary	ADJ
hls-12456	53	17	malignant	malignant	ADJ
hls-12456	53	18	cells	cell	NOUN
hls-12456	53	19	and	and	CCONJ
hls-12456	53	20	metastatic	metastatic	ADJ
hls-12456	53	21	tumor	tumor	NOUN
hls-12456	53	22	nodes	node	NOUN
hls-12456	53	23	.	.	PUNCT
hls-12456	54	1	the	the	DET
hls-12456	54	2	analysis	analysis	NOUN
hls-12456	54	3	included	include	VERB
hls-12456	54	4	30	30	NUM
hls-12456	54	5	cases	case	NOUN
hls-12456	54	6	of	of	ADP
hls-12456	54	7	primary	primary	ADJ
hls-12456	54	8	cancer	cancer	NOUN
hls-12456	54	9	and	and	CCONJ
hls-12456	54	10	30	30	NUM
hls-12456	54	11	cases	case	NOUN
hls-12456	54	12	of	of	ADP
hls-12456	54	13	metastatic	metastatic	ADJ
hls-12456	54	14	foci	focus	NOUN
hls-12456	54	15	.	.	PUNCT
hls-12456	55	1	gallocyanin	gallocyanin	NOUN
hls-12456	55	2	-	-	PUNCT
hls-12456	55	3	chromium	chromium	NOUN
hls-12456	55	4	gallate	gallate	NOUN
hls-12456	55	5	staining	stain	VERB
hls-12456	55	6	with	with	ADP
hls-12456	55	7	baoh	baoh	NOUN
hls-12456	55	8	control	control	NOUN
hls-12456	55	9	was	be	AUX
hls-12456	55	10	used	use	VERB
hls-12456	55	11	to	to	PART
hls-12456	55	12	identify	identify	VERB
hls-12456	55	13	dna	dna	NOUN
hls-12456	55	14	and	and	CCONJ
hls-12456	55	15	rna	rna	PROPN
hls-12456	55	16	.	.	PUNCT
hls-12456	56	1	this	this	DET
hls-12456	56	2	method	method	NOUN
hls-12456	56	3	contributed	contribute	VERB
hls-12456	56	4	to	to	ADP
hls-12456	56	5	determining	determine	VERB
hls-12456	56	6	the	the	DET
hls-12456	56	7	total	total	ADJ
hls-12456	56	8	volume	volume	NOUN
hls-12456	56	9	of	of	ADP
hls-12456	56	10	nucleic	nucleic	ADJ
hls-12456	56	11	acids	acid	NOUN
hls-12456	56	12	(	(	PUNCT
hls-12456	56	13	dna	dna	NOUN
hls-12456	56	14	and	and	CCONJ
hls-12456	56	15	rna	rna	PROPN
hls-12456	56	16	)	)	PUNCT
hls-12456	56	17	.	.	PUNCT
hls-12456	57	1	in	in	ADP
hls-12456	57	2	cases	case	NOUN
hls-12456	57	3	where	where	SCONJ
hls-12456	57	4	the	the	DET
hls-12456	57	5	samples	sample	NOUN
hls-12456	57	6	were	be	AUX
hls-12456	57	7	treated	treat	VERB
hls-12456	57	8	solely	solely	ADV
hls-12456	57	9	with	with	ADP
hls-12456	57	10	baoh	baoh	NOUN
hls-12456	57	11	,	,	PUNCT
hls-12456	57	12	only	only	ADV
hls-12456	57	13	the	the	DET
hls-12456	57	14	amount	amount	NOUN
hls-12456	57	15	of	of	ADP
hls-12456	57	16	dna	dna	NOUN
hls-12456	57	17	was	be	AUX
hls-12456	57	18	determined	determine	VERB
hls-12456	57	19	.	.	PUNCT
hls-12456	58	1	quantitative	quantitative	ADJ
hls-12456	58	2	analysis	analysis	NOUN
hls-12456	58	3	of	of	ADP
hls-12456	58	4	dna	dna	NOUN
hls-12456	58	5	and	and	CCONJ
hls-12456	58	6	rna	rna	NOUN
hls-12456	58	7	in	in	ADP
hls-12456	58	8	histological	histological	ADJ
hls-12456	58	9	samples	sample	NOUN
hls-12456	58	10	was	be	AUX
hls-12456	58	11	carried	carry	VERB
hls-12456	58	12	out	out	ADP
hls-12456	58	13	using	use	VERB
hls-12456	58	14	the	the	DET
hls-12456	58	15	automated	automate	VERB
hls-12456	58	16	complex	complex	ADJ
hls-12456	58	17	“	"	PUNCT
hls-12456	58	18	protva	protva	NOUN
hls-12456	58	19	-	-	PUNCT
hls-12456	58	20	pm11	pm11	VERB
hls-12456	58	21	-	-	PUNCT
hls-12456	58	22	dvk-3	dvk-3	NOUN
hls-12456	58	23	m	m	NOUN
hls-12456	58	24	”	"	PUNCT
hls-12456	58	25	and	and	CCONJ
hls-12456	58	26	the	the	DET
hls-12456	58	27	corresponding	corresponding	ADJ
hls-12456	58	28	software	software	NOUN
hls-12456	58	29	.	.	PUNCT
hls-12456	59	1	scanning	scanning	NOUN
hls-12456	59	2	was	be	AUX
hls-12456	59	3	performed	perform	VERB
hls-12456	59	4	with	with	ADP
hls-12456	59	5	the	the	DET
hls-12456	59	6	following	follow	VERB
hls-12456	59	7	parameters	parameter	NOUN
hls-12456	59	8	:	:	PUNCT
hls-12456	59	9	frame	frame	NOUN
hls-12456	59	10	size	size	NOUN
hls-12456	59	11	100×150	100×150	NUM
hls-12456	59	12	µm	µm	NOUN
hls-12456	59	13	,	,	PUNCT
hls-12456	59	14	probe	probe	NOUN
hls-12456	59	15	0.5	0.5	NUM
hls-12456	59	16	µm	µm	NOUN
hls-12456	59	17	,	,	PUNCT
hls-12456	59	18	step	step	NOUN
hls-12456	59	19	x=5	x=5	PROPN
hls-12456	59	20	µm	µm	NOUN
hls-12456	59	21	,	,	PUNCT
hls-12456	59	22	and	and	CCONJ
hls-12456	59	23	y=15	y=15	PROPN
hls-12456	59	24	µm	µm	PROPN
hls-12456	59	25	.	.	PUNCT
hls-12456	59	26	monochromatic	monochromatic	ADJ
hls-12456	59	27	light	light	NOUN
hls-12456	59	28	with	with	ADP
hls-12456	59	29	a	a	DET
hls-12456	59	30	wavelength	wavelength	NOUN
hls-12456	59	31	of	of	ADP
hls-12456	59	32	560	560	NUM
hls-12456	59	33	nm	nm	NOUN
hls-12456	59	34	was	be	AUX
hls-12456	59	35	also	also	ADV
hls-12456	59	36	used	use	VERB
hls-12456	59	37	.	.	PUNCT
hls-12456	60	1	the	the	DET
hls-12456	60	2	determination	determination	NOUN
hls-12456	60	3	of	of	ADP
hls-12456	60	4	the	the	DET
hls-12456	60	5	amount	amount	NOUN
hls-12456	60	6	of	of	ADP
hls-12456	60	7	dna	dna	PROPN
hls-12456	60	8	and	and	CCONJ
hls-12456	60	9	rna	rna	PROPN
hls-12456	60	10	was	be	AUX
hls-12456	60	11	based	base	VERB
hls-12456	60	12	on	on	ADP
hls-12456	60	13	the	the	DET
hls-12456	60	14	extinction	extinction	NOUN
hls-12456	60	15	in	in	ADP
hls-12456	60	16	the	the	DET
hls-12456	60	17	nucleus	nucleus	NOUN
hls-12456	60	18	and	and	CCONJ
hls-12456	60	19	cytoplasm	cytoplasm	NOUN
hls-12456	60	20	.	.	PUNCT
hls-12456	61	1	for	for	ADP
hls-12456	61	2	every	every	DET
hls-12456	61	3	batch	batch	NOUN
hls-12456	61	4	of	of	ADP
hls-12456	61	5	samples	sample	NOUN
hls-12456	61	6	,	,	PUNCT
hls-12456	61	7	fresh	fresh	ADJ
hls-12456	61	8	staining	stain	VERB
hls-12456	61	9	solutions	solution	NOUN
hls-12456	61	10	were	be	AUX
hls-12456	61	11	made	make	VERB
hls-12456	61	12	for	for	ADP
hls-12456	61	13	the	the	DET
hls-12456	61	14	gallocyanin	gallocyanin	NOUN
hls-12456	61	15	-	-	PUNCT
hls-12456	61	16	chromium	chromium	NOUN
hls-12456	61	17	gallate	gallate	NOUN
hls-12456	61	18	staining	stain	VERB
hls-12456	61	19	technique	technique	NOUN
hls-12456	61	20	,	,	PUNCT
hls-12456	61	21	and	and	CCONJ
hls-12456	61	22	staining	stain	VERB
hls-12456	61	23	times	time	NOUN
hls-12456	61	24	were	be	AUX
hls-12456	61	25	closely	closely	ADV
hls-12456	61	26	monitored	monitor	VERB
hls-12456	61	27	.	.	PUNCT
hls-12456	62	1	to	to	PART
hls-12456	62	2	keep	keep	VERB
hls-12456	62	3	an	an	DET
hls-12456	62	4	eye	eye	NOUN
hls-12456	62	5	on	on	ADP
hls-12456	62	6	the	the	DET
hls-12456	62	7	staining	stain	VERB
hls-12456	62	8	protocol	protocol	NOUN
hls-12456	62	9	’s	’s	PART
hls-12456	62	10	consistency	consistency	NOUN
hls-12456	62	11	,	,	PUNCT
hls-12456	62	12	positive	positive	ADJ
hls-12456	62	13	and	and	CCONJ
hls-12456	62	14	negative	negative	ADJ
hls-12456	62	15	control	control	NOUN
hls-12456	62	16	slides	slide	NOUN
hls-12456	62	17	were	be	AUX
hls-12456	62	18	included	include	VERB
hls-12456	62	19	with	with	ADP
hls-12456	62	20	every	every	DET
hls-12456	62	21	staining	stain	VERB
hls-12456	62	22	run	run	NOUN
hls-12456	62	23	.	.	PUNCT
hls-12456	63	1	before	before	SCONJ
hls-12456	63	2	the	the	DET
hls-12456	63	3	experimental	experimental	ADJ
hls-12456	63	4	samples	sample	NOUN
hls-12456	63	5	were	be	AUX
hls-12456	63	6	analyzed	analyze	VERB
hls-12456	63	7	,	,	PUNCT
hls-12456	63	8	the	the	DET
hls-12456	63	9	optical	optical	ADJ
hls-12456	63	10	density	density	NOUN
hls-12456	63	11	measurements	measurement	NOUN
hls-12456	63	12	from	from	ADP
hls-12456	63	13	the	the	DET
hls-12456	63	14	control	control	NOUN
hls-12456	63	15	slides	slide	NOUN
hls-12456	63	16	had	have	VERB
hls-12456	63	17	to	to	PART
hls-12456	63	18	fall	fall	VERB
hls-12456	63	19	within	within	ADP
hls-12456	63	20	specified	specified	ADJ
hls-12456	63	21	acceptable	acceptable	ADJ
hls-12456	63	22	ranges	range	NOUN
hls-12456	63	23	.	.	PUNCT
hls-12456	64	1	using	use	VERB
hls-12456	64	2	standard	standard	ADJ
hls-12456	64	3	solutions	solution	NOUN
hls-12456	64	4	containing	contain	VERB
hls-12456	64	5	known	know	VERB
hls-12456	64	6	concentrations	concentration	NOUN
hls-12456	64	7	of	of	ADP
hls-12456	64	8	dna	dna	PROPN
hls-12456	64	9	and	and	CCONJ
hls-12456	64	10	rna	rna	PROPN
hls-12456	64	11	,	,	PUNCT
hls-12456	64	12	the	the	DET
hls-12456	64	13	automated	automate	VERB
hls-12456	64	14	complex	complex	ADJ
hls-12456	64	15	“	"	PUNCT
hls-12456	64	16	protva	protva	NOUN
hls-12456	64	17	-	-	PUNCT
hls-12456	64	18	pm11	pm11	VERB
hls-12456	64	19	-	-	PUNCT
hls-12456	64	20	dvk-3	dvk-3	NOUN
hls-12456	64	21	m	m	NOUN
hls-12456	64	22	”	"	PUNCT
hls-12456	64	23	was	be	AUX
hls-12456	64	24	calibrated	calibrate	VERB
hls-12456	64	25	before	before	ADP
hls-12456	64	26	each	each	DET
hls-12456	64	27	analysis	analysis	NOUN
hls-12456	64	28	to	to	PART
hls-12456	64	29	guarantee	guarantee	VERB
hls-12456	64	30	the	the	DET
hls-12456	64	31	accuracy	accuracy	NOUN
hls-12456	64	32	and	and	CCONJ
hls-12456	64	33	repeatability	repeatability	NOUN
hls-12456	64	34	of	of	ADP
hls-12456	64	35	the	the	DET
hls-12456	64	36	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	64	37	analysis	analysis	NOUN
hls-12456	64	38	.	.	PUNCT
hls-12456	65	1	as	as	ADP
hls-12456	65	2	a	a	DET
hls-12456	65	3	result	result	NOUN
hls-12456	65	4	,	,	PUNCT
hls-12456	65	5	the	the	DET
hls-12456	65	6	nucleic	nucleic	ADJ
hls-12456	65	7	acid	acid	NOUN
hls-12456	65	8	levels	level	NOUN
hls-12456	65	9	in	in	ADP
hls-12456	65	10	the	the	DET
hls-12456	65	11	tumor	tumor	NOUN
hls-12456	65	12	cell	cell	NOUN
hls-12456	65	13	samples	sample	NOUN
hls-12456	65	14	could	could	AUX
hls-12456	65	15	be	be	AUX
hls-12456	65	16	accurately	accurately	ADV
hls-12456	65	17	quantified	quantify	VERB
hls-12456	65	18	.	.	PUNCT
hls-12456	66	1	furthermore	furthermore	ADV
hls-12456	66	2	,	,	PUNCT
hls-12456	66	3	each	each	DET
hls-12456	66	4	sample	sample	NOUN
hls-12456	66	5	underwent	undergo	VERB
hls-12456	66	6	double	double	ADJ
hls-12456	66	7	measurements	measurement	NOUN
hls-12456	66	8	in	in	ADP
hls-12456	66	9	order	order	NOUN
hls-12456	66	10	to	to	PART
hls-12456	66	11	evaluate	evaluate	VERB
hls-12456	66	12	intra	intra	ADJ
hls-12456	66	13	-	-	ADJ
hls-12456	66	14	sample	sample	ADJ
hls-12456	66	15	variability	variability	NOUN
hls-12456	66	16	.	.	PUNCT
hls-12456	67	1	in	in	ADP
hls-12456	67	2	order	order	NOUN
hls-12456	67	3	for	for	SCONJ
hls-12456	67	4	these	these	DET
hls-12456	67	5	repeated	repeat	VERB
hls-12456	67	6	measurements	measurement	NOUN
hls-12456	67	7	to	to	PART
hls-12456	67	8	be	be	AUX
hls-12456	67	9	incorporated	incorporate	VERB
hls-12456	67	10	into	into	ADP
hls-12456	67	11	the	the	DET
hls-12456	67	12	data	datum	NOUN
hls-12456	67	13	analysis	analysis	NOUN
hls-12456	67	14	,	,	PUNCT
hls-12456	67	15	the	the	DET
hls-12456	67	16	coefficient	coefficient	NOUN
hls-12456	67	17	of	of	ADP
hls-12456	67	18	variation	variation	NOUN
hls-12456	67	19	had	have	VERB
hls-12456	67	20	to	to	PART
hls-12456	67	21	be	be	AUX
hls-12456	67	22	less	less	ADJ
hls-12456	67	23	than	than	ADP
hls-12456	67	24	10	10	NUM
hls-12456	67	25	%	%	NOUN
hls-12456	67	26	.	.	PUNCT
hls-12456	68	1	to	to	PART
hls-12456	68	2	determine	determine	VERB
hls-12456	68	3	the	the	DET
hls-12456	68	4	amount	amount	NOUN
hls-12456	68	5	of	of	ADP
hls-12456	68	6	rna	rna	NOUN
hls-12456	68	7	in	in	ADP
hls-12456	68	8	cells	cell	NOUN
hls-12456	68	9	of	of	ADP
hls-12456	68	10	primary	primary	ADJ
hls-12456	68	11	tumors	tumor	NOUN
hls-12456	68	12	and	and	CCONJ
hls-12456	68	13	their	their	PRON
hls-12456	68	14	metastases	metastasis	NOUN
hls-12456	68	15	,	,	PUNCT
hls-12456	68	16	the	the	DET
hls-12456	68	17	difference	difference	NOUN
hls-12456	68	18	in	in	ADP
hls-12456	68	19	the	the	DET
hls-12456	68	20	mean	mean	ADJ
hls-12456	68	21	values	value	NOUN
hls-12456	68	22	of	of	ADP
hls-12456	68	23	the	the	DET
hls-12456	68	24	relative	relative	ADJ
hls-12456	68	25	optical	optical	ADJ
hls-12456	68	26	density	density	NOUN
hls-12456	68	27	of	of	ADP
hls-12456	68	28	nuclei	nucleus	NOUN
hls-12456	68	29	before	before	ADV
hls-12456	68	30	and	and	CCONJ
hls-12456	68	31	after	after	ADP
hls-12456	68	32	baoh	baoh	NOUN
hls-12456	68	33	treatment	treatment	NOUN
hls-12456	68	34	was	be	AUX
hls-12456	68	35	applied	apply	VERB
hls-12456	68	36	.	.	PUNCT
hls-12456	69	1	thus	thus	ADV
hls-12456	69	2	,	,	PUNCT
hls-12456	69	3	the	the	DET
hls-12456	69	4	difference	difference	NOUN
hls-12456	69	5	in	in	ADP
hls-12456	69	6	the	the	DET
hls-12456	69	7	amount	amount	NOUN
hls-12456	69	8	of	of	ADP
hls-12456	69	9	rna	rna	NOUN
hls-12456	69	10	between	between	ADP
hls-12456	69	11	the	the	DET
hls-12456	69	12	cells	cell	NOUN
hls-12456	69	13	of	of	ADP
hls-12456	69	14	the	the	DET
hls-12456	69	15	primary	primary	ADJ
hls-12456	69	16	tumor	tumor	NOUN
hls-12456	69	17	and	and	CCONJ
hls-12456	69	18	its	its	PRON
hls-12456	69	19	metastatic	metastatic	ADJ
hls-12456	69	20	nodes	node	NOUN
hls-12456	69	21	was	be	AUX
hls-12456	69	22	compared	compare	VERB
hls-12456	69	23	.	.	PUNCT
hls-12456	70	1	the	the	DET
hls-12456	70	2	average	average	ADJ
hls-12456	70	3	amount	amount	NOUN
hls-12456	70	4	of	of	ADP
hls-12456	70	5	dna	dna	NOUN
hls-12456	70	6	in	in	ADP
hls-12456	70	7	the	the	DET
hls-12456	70	8	nuclei	nucleus	NOUN
hls-12456	70	9	of	of	ADP
hls-12456	70	10	tumor	tumor	NOUN
hls-12456	70	11	cells	cell	NOUN
hls-12456	70	12	of	of	ADP
hls-12456	70	13	primary	primary	ADJ
hls-12456	70	14	cancer	cancer	NOUN
hls-12456	70	15	and	and	CCONJ
hls-12456	70	16	its	its	PRON
hls-12456	70	17	metastases	metastasis	NOUN
hls-12456	70	18	was	be	AUX
hls-12456	70	19	estimated	estimate	VERB
hls-12456	70	20	using	use	VERB
hls-12456	70	21	the	the	DET
hls-12456	70	22	dna	dna	PROPN
hls-12456	70	23	accumulation	accumulation	NOUN
hls-12456	70	24	index	index	NOUN
hls-12456	70	25	,	,	PUNCT
hls-12456	70	26	representing	represent	VERB
hls-12456	70	27	the	the	DET
hls-12456	70	28	weighted	weighted	ADJ
hls-12456	70	29	average	average	ADJ
hls-12456	70	30	arithmetic	arithmetic	ADJ
hls-12456	70	31	amount	amount	NOUN
hls-12456	70	32	of	of	ADP
hls-12456	70	33	dna	dna	NOUN
hls-12456	70	34	in	in	ADP
hls-12456	70	35	units	unit	NOUN
hls-12456	70	36	of	of	ADP
hls-12456	70	37	ploidy	ploidy	ADJ
hls-12456	70	38	per	per	ADP
hls-12456	70	39	nucleus	nucleus	NOUN
hls-12456	70	40	,	,	PUNCT
hls-12456	70	41	determined	determine	VERB
hls-12456	70	42	by	by	ADP
hls-12456	70	43	comparing	compare	VERB
hls-12456	70	44	with	with	ADP
hls-12456	70	45	the	the	DET
hls-12456	70	46	average	average	ADJ
hls-12456	70	47	dna	dna	NOUN
hls-12456	70	48	content	content	NOUN
hls-12456	70	49	in	in	ADP
hls-12456	70	50	the	the	DET
hls-12456	70	51	nuclei	nucleus	NOUN
hls-12456	70	52	of	of	ADP
hls-12456	70	53	small	small	ADJ
hls-12456	70	54	lymphocytes	lymphocyte	NOUN
hls-12456	70	55	in	in	ADP
hls-12456	70	56	the	the	DET
hls-12456	70	57	analyzed	analyze	VERB
hls-12456	70	58	sections	section	NOUN
hls-12456	70	59	.	.	PUNCT
hls-12456	71	1	various	various	ADJ
hls-12456	71	2	scientific	scientific	ADJ
hls-12456	71	3	methods	method	NOUN
hls-12456	71	4	were	be	AUX
hls-12456	71	5	employed	employ	VERB
hls-12456	71	6	in	in	ADP
hls-12456	71	7	this	this	DET
hls-12456	71	8	study	study	NOUN
hls-12456	71	9	.	.	PUNCT
hls-12456	72	1	specifically	specifically	ADV
hls-12456	72	2	,	,	PUNCT
hls-12456	72	3	for	for	ADP
hls-12456	72	4	the	the	DET
hls-12456	72	5	analysis	analysis	NOUN
hls-12456	72	6	of	of	ADP
hls-12456	72	7	categorical	categorical	ADJ
hls-12456	72	8	and	and	CCONJ
hls-12456	72	9	numerical	numerical	ADJ
hls-12456	72	10	data	datum	NOUN
hls-12456	72	11	obtained	obtain	VERB
hls-12456	72	12	during	during	ADP
hls-12456	72	13	the	the	DET
hls-12456	72	14	study	study	NOUN
hls-12456	72	15	of	of	ADP
hls-12456	72	16	dna	dna	PROPN
hls-12456	72	17	and	and	CCONJ
hls-12456	72	18	rna	rna	NOUN
hls-12456	72	19	levels	level	NOUN
hls-12456	72	20	in	in	ADP
hls-12456	72	21	tumor	tumor	NOUN
hls-12456	72	22	cells	cell	NOUN
hls-12456	72	23	,	,	PUNCT
hls-12456	72	24	the	the	DET
hls-12456	72	25	discrete	discrete	ADJ
hls-12456	72	26	statistics	statistic	NOUN
hls-12456	72	27	method	method	NOUN
hls-12456	72	28	was	be	AUX
hls-12456	72	29	applied	apply	VERB
hls-12456	72	30	.	.	PUNCT
hls-12456	73	1	this	this	DET
hls-12456	73	2	method	method	NOUN
hls-12456	73	3	helped	helped	AUX
hls-12456	73	4	establish	establish	VERB
hls-12456	73	5	relationships	relationship	NOUN
hls-12456	73	6	between	between	ADP
hls-12456	73	7	data	datum	NOUN
hls-12456	73	8	and	and	CCONJ
hls-12456	73	9	determine	determine	VERB
hls-12456	73	10	their	their	PRON
hls-12456	73	11	statistical	statistical	ADJ
hls-12456	73	12	significance	significance	NOUN
hls-12456	73	13	.	.	PUNCT
hls-12456	74	1	for	for	ADP
hls-12456	74	2	a	a	DET
hls-12456	74	3	more	more	ADV
hls-12456	74	4	detailed	detailed	ADJ
hls-12456	74	5	study	study	NOUN
hls-12456	74	6	of	of	ADP
hls-12456	74	7	parameters	parameter	NOUN
hls-12456	74	8	such	such	ADJ
hls-12456	74	9	as	as	ADP
hls-12456	74	10	levels	level	NOUN
hls-12456	74	11	of	of	ADP
hls-12456	74	12	nucleic	nucleic	ADJ
hls-12456	74	13	acids	acid	NOUN
hls-12456	74	14	in	in	ADP
hls-12456	74	15	primary	primary	ADJ
hls-12456	74	16	and	and	CCONJ
hls-12456	74	17	metastatic	metastatic	ADJ
hls-12456	74	18	tumors	tumor	NOUN
hls-12456	74	19	,	,	PUNCT
hls-12456	74	20	average	average	ADJ
hls-12456	74	21	nuclear	nuclear	ADJ
hls-12456	74	22	diameter	diameter	NOUN
hls-12456	74	23	,	,	PUNCT
hls-12456	74	24	coefficient	coefficient	NOUN
hls-12456	74	25	of	of	ADP
hls-12456	74	26	variation	variation	NOUN
hls-12456	74	27	of	of	ADP
hls-12456	74	28	the	the	DET
hls-12456	74	29	nuclear	nuclear	ADJ
hls-12456	74	30	diameter	diameter	NOUN
hls-12456	74	31	of	of	ADP
hls-12456	74	32	tumor	tumor	NOUN
hls-12456	74	33	cells	cell	NOUN
hls-12456	74	34	,	,	PUNCT
hls-12456	74	35	and	and	CCONJ
hls-12456	74	36	dna	dna	PROPN
hls-12456	74	37	accumulation	accumulation	NOUN
hls-12456	74	38	index	index	NOUN
hls-12456	74	39	,	,	PUNCT
hls-12456	74	40	frequency	frequency	NOUN
hls-12456	74	41	analysis	analysis	NOUN
hls-12456	74	42	was	be	AUX
hls-12456	74	43	applied	apply	VERB
hls-12456	74	44	.	.	PUNCT
hls-12456	75	1	this	this	DET
hls-12456	75	2	methodological	methodological	ADJ
hls-12456	75	3	approach	approach	NOUN
hls-12456	75	4	allowed	allow	VERB
hls-12456	75	5	for	for	ADP
hls-12456	75	6	a	a	DET
hls-12456	75	7	quantitative	quantitative	ADJ
hls-12456	75	8	assessment	assessment	NOUN
hls-12456	75	9	of	of	ADP
hls-12456	75	10	the	the	DET
hls-12456	75	11	frequency	frequency	NOUN
hls-12456	75	12	of	of	ADP
hls-12456	75	13	the	the	DET
hls-12456	75	14	occurrence	occurrence	NOUN
hls-12456	75	15	of	of	ADP
hls-12456	75	16	different	different	ADJ
hls-12456	75	17	indicators	indicator	NOUN
hls-12456	75	18	.	.	PUNCT
hls-12456	76	1	the	the	DET
hls-12456	76	2	use	use	NOUN
hls-12456	76	3	of	of	ADP
hls-12456	76	4	cluster	cluster	NOUN
hls-12456	76	5	analysis	analysis	NOUN
hls-12456	76	6	enabled	enable	VERB
hls-12456	76	7	a	a	DET
hls-12456	76	8	thorough	thorough	ADJ
hls-12456	76	9	investigation	investigation	NOUN
hls-12456	76	10	of	of	ADP
hls-12456	76	11	the	the	DET
hls-12456	76	12	structure	structure	NOUN
hls-12456	76	13	of	of	ADP
hls-12456	76	14	the	the	DET
hls-12456	76	15	collected	collect	VERB
hls-12456	76	16	data	datum	NOUN
hls-12456	76	17	,	,	PUNCT
hls-12456	76	18	the	the	DET
hls-12456	76	19	identification	identification	NOUN
hls-12456	76	20	of	of	ADP
hls-12456	76	21	subgroups	subgroup	NOUN
hls-12456	76	22	of	of	ADP
hls-12456	76	23	samples	sample	NOUN
hls-12456	76	24	based	base	VERB
hls-12456	76	25	on	on	ADP
hls-12456	76	26	the	the	DET
hls-12456	76	27	analysis	analysis	NOUN
hls-12456	76	28	of	of	ADP
hls-12456	76	29	the	the	DET
hls-12456	76	30	similarity	similarity	NOUN
hls-12456	76	31	of	of	ADP
hls-12456	76	32	different	different	ADJ
hls-12456	76	33	characteristics	characteristic	NOUN
hls-12456	76	34	,	,	PUNCT
hls-12456	76	35	and	and	CCONJ
hls-12456	76	36	the	the	DET
hls-12456	76	37	determination	determination	NOUN
hls-12456	76	38	of	of	ADP
hls-12456	76	39	key	key	ADJ
hls-12456	76	40	factors	factor	NOUN
hls-12456	76	41	influencing	influence	VERB
hls-12456	76	42	dna	dna	NOUN
hls-12456	76	43	and	and	CCONJ
hls-12456	76	44	rna	rna	NOUN
hls-12456	76	45	indicators	indicator	NOUN
hls-12456	76	46	in	in	ADP
hls-12456	76	47	tumor	tumor	NOUN
hls-12456	76	48	cells	cell	NOUN
hls-12456	76	49	.	.	PUNCT
hls-12456	77	1	to	to	PART
hls-12456	77	2	assess	assess	VERB
hls-12456	77	3	global	global	ADJ
hls-12456	77	4	trends	trend	NOUN
hls-12456	77	5	in	in	ADP
hls-12456	77	6	this	this	DET
hls-12456	77	7	field	field	NOUN
hls-12456	77	8	and	and	CCONJ
hls-12456	77	9	support	support	NOUN
hls-12456	77	10	conclusions	conclusion	NOUN
hls-12456	77	11	,	,	PUNCT
hls-12456	77	12	a	a	DET
hls-12456	77	13	comprehensive	comprehensive	ADJ
hls-12456	77	14	review	review	NOUN
hls-12456	77	15	of	of	ADP
hls-12456	77	16	contemporary	contemporary	ADJ
hls-12456	77	17	scientific	scientific	ADJ
hls-12456	77	18	publications	publication	NOUN
hls-12456	77	19	was	be	AUX
hls-12456	77	20	conducted	conduct	VERB
hls-12456	77	21	.	.	PUNCT
hls-12456	78	1	information	information	NOUN
hls-12456	78	2	retrieval	retrieval	NOUN
hls-12456	78	3	was	be	AUX
hls-12456	78	4	performed	perform	VERB
hls-12456	78	5	using	use	VERB
hls-12456	78	6	the	the	DET
hls-12456	78	7	bibliographic	bibliographic	ADJ
hls-12456	78	8	method	method	NOUN
hls-12456	78	9	,	,	PUNCT
hls-12456	78	10	analyzing	analyze	VERB
hls-12456	78	11	data	datum	NOUN
hls-12456	78	12	from	from	ADP
hls-12456	78	13	bibliometric	bibliometric	ADJ
hls-12456	78	14	databases	database	NOUN
hls-12456	78	15	.	.	PUNCT
hls-12456	79	1	results	result	VERB
hls-12456	79	2	the	the	DET
hls-12456	79	3	analysis	analysis	NOUN
hls-12456	79	4	of	of	ADP
hls-12456	79	5	data	datum	NOUN
hls-12456	79	6	reflecting	reflect	VERB
hls-12456	79	7	the	the	DET
hls-12456	79	8	level	level	NOUN
hls-12456	79	9	of	of	ADP
hls-12456	79	10	dna	dna	PROPN
hls-12456	79	11	concentration	concentration	NOUN
hls-12456	79	12	,	,	PUNCT
hls-12456	79	13	determined	determine	VERB
hls-12456	79	14	based	base	VERB
hls-12456	79	15	on	on	ADP
hls-12456	79	16	extinction	extinction	NOUN
hls-12456	79	17	,	,	PUNCT
hls-12456	79	18	in	in	ADP
hls-12456	79	19	the	the	DET
hls-12456	79	20	nuclei	nucleus	NOUN
hls-12456	79	21	of	of	ADP
hls-12456	79	22	primary	primary	ADJ
hls-12456	79	23	and	and	CCONJ
hls-12456	79	24	metastatic	metastatic	ADJ
hls-12456	79	25	tumor	tumor	NOUN
hls-12456	79	26	cells	cell	NOUN
hls-12456	79	27	indicates	indicate	VERB
hls-12456	79	28	that	that	SCONJ
hls-12456	79	29	in	in	ADP
hls-12456	79	30	metastases	metastasis	NOUN
hls-12456	79	31	,	,	PUNCT
hls-12456	79	32	dna	dna	NOUN
hls-12456	79	33	concentration	concentration	NOUN
hls-12456	79	34	can	can	AUX
hls-12456	79	35	be	be	AUX
hls-12456	79	36	either	either	CCONJ
hls-12456	79	37	higher	high	ADJ
hls-12456	79	38	(	(	PUNCT
hls-12456	79	39	in	in	ADP
hls-12456	79	40	34.5	34.5	NUM
hls-12456	79	41	%	%	NOUN
hls-12456	79	42	of	of	ADP
hls-12456	79	43	cases	case	NOUN
hls-12456	79	44	)	)	PUNCT
hls-12456	79	45	or	or	CCONJ
hls-12456	79	46	lower	low	ADJ
hls-12456	79	47	(	(	PUNCT
hls-12456	79	48	in	in	ADP
hls-12456	79	49	55.2	55.2	NUM
hls-12456	79	50	%	%	NOUN
hls-12456	79	51	of	of	ADP
hls-12456	79	52	cases	case	NOUN
hls-12456	79	53	)	)	PUNCT
hls-12456	79	54	,	,	PUNCT
hls-12456	79	55	and	and	CCONJ
hls-12456	79	56	in	in	ADP
hls-12456	79	57	rare	rare	ADJ
hls-12456	79	58	cases	case	NOUN
hls-12456	79	59	,	,	PUNCT
hls-12456	79	60	even	even	ADV
hls-12456	79	61	coincide	coincide	VERB
hls-12456	79	62	with	with	ADP
hls-12456	79	63	the	the	DET
hls-12456	79	64	indicators	indicator	NOUN
hls-12456	79	65	of	of	ADP
hls-12456	79	66	the	the	DET
hls-12456	79	67	primary	primary	ADJ
hls-12456	79	68	population	population	NOUN
hls-12456	79	69	of	of	ADP
hls-12456	79	70	tumor	tumor	NOUN
hls-12456	79	71	cells	cell	NOUN
hls-12456	79	72	(	(	PUNCT
hls-12456	79	73	10.3	10.3	NUM
hls-12456	79	74	%	%	NOUN
hls-12456	79	75	)	)	PUNCT
hls-12456	79	76	;	;	PUNCT
hls-12456	79	77	the	the	DET
hls-12456	79	78	presented	present	VERB
hls-12456	79	79	results	result	NOUN
hls-12456	79	80	are	be	AUX
hls-12456	79	81	shown	show	VERB
hls-12456	79	82	in	in	ADP
hls-12456	79	83	table	table	NOUN
hls-12456	79	84	1	1	NUM
hls-12456	79	85	.	.	PUNCT
hls-12456	79	86	similar	similar	ADJ
hls-12456	79	87	findings	finding	NOUN
hls-12456	79	88	suggest	suggest	VERB
hls-12456	79	89	both	both	DET
hls-12456	79	90	polymorphism	polymorphism	NOUN
hls-12456	79	91	at	at	ADP
hls-12456	79	92	the	the	DET
hls-12456	79	93	nuclear	nuclear	ADJ
hls-12456	79	94	level	level	NOUN
hls-12456	79	95	and	and	CCONJ
hls-12456	79	96	variability	variability	NOUN
hls-12456	79	97	in	in	ADP
hls-12456	79	98	dna	dna	NOUN
hls-12456	79	99	synthesis	synthesis	NOUN
hls-12456	79	100	processes	process	NOUN
hls-12456	79	101	among	among	ADP
hls-12456	79	102	different	different	ADJ
hls-12456	79	103	populations	population	NOUN
hls-12456	79	104	of	of	ADP
hls-12456	79	105	tumor	tumor	NOUN
hls-12456	79	106	cells	cell	NOUN
hls-12456	79	107	forming	form	VERB
hls-12456	79	108	metastases	metastasis	NOUN
hls-12456	79	109	.	.	PUNCT
hls-12456	80	1	an	an	DET
hls-12456	80	2	effective	effective	ADJ
hls-12456	80	3	indicator	indicator	NOUN
hls-12456	80	4	for	for	ADP
hls-12456	80	5	assessing	assess	VERB
hls-12456	80	6	cell	cell	NOUN
hls-12456	80	7	variability	variability	NOUN
hls-12456	80	8	in	in	ADP
hls-12456	80	9	the	the	DET
hls-12456	80	10	process	process	NOUN
hls-12456	80	11	of	of	ADP
hls-12456	80	12	metastasis	metastasis	NOUN
hls-12456	80	13	is	be	AUX
hls-12456	80	14	the	the	DET
hls-12456	80	15	dna	dna	PROPN
hls-12456	80	16	accumulation	accumulation	NOUN
hls-12456	80	17	index	index	NOUN
hls-12456	80	18	(	(	PUNCT
hls-12456	80	19	dnaai).6	dnaai).6	PROPN
hls-12456	80	20	dnaai	dnaai	VERB
hls-12456	80	21	determines	determine	VERB
hls-12456	80	22	the	the	DET
hls-12456	80	23	weighted	weight	VERB
hls-12456	80	24	arithmetic	arithmetic	ADJ
hls-12456	80	25	mean	mean	NOUN
hls-12456	80	26	amount	amount	NOUN
hls-12456	80	27	of	of	ADP
hls-12456	80	28	dna	dna	NOUN
hls-12456	80	29	per	per	ADP
hls-12456	80	30	nucleus	nucleus	NOUN
hls-12456	80	31	in	in	ADP
hls-12456	80	32	ploid	ploid	PROPN
hls-12456	80	33	units	unit	NOUN
hls-12456	80	34	.	.	PUNCT
hls-12456	81	1	the	the	DET
hls-12456	81	2	results	result	NOUN
hls-12456	81	3	shown	show	VERB
hls-12456	81	4	in	in	ADP
hls-12456	81	5	table	table	NOUN
hls-12456	81	6	2	2	NUM
hls-12456	81	7	demonstrate	demonstrate	VERB
hls-12456	81	8	the	the	DET
hls-12456	81	9	fact	fact	NOUN
hls-12456	81	10	that	that	SCONJ
hls-12456	81	11	heteroand	heteroand	ADJ
hls-12456	81	12	polyploidy	polyploidy	NOUN
hls-12456	81	13	in	in	ADP
hls-12456	81	14	metastases	metastasis	NOUN
hls-12456	81	15	are	be	AUX
hls-12456	81	16	not	not	PART
hls-12456	81	17	uniform	uniform	ADJ
hls-12456	81	18	.	.	PUNCT
hls-12456	82	1	the	the	DET
hls-12456	82	2	uneven	uneven	ADJ
hls-12456	82	3	distribution	distribution	NOUN
hls-12456	82	4	of	of	ADP
hls-12456	82	5	molecular	molecular	ADJ
hls-12456	82	6	-	-	PUNCT
hls-12456	82	7	genetic	genetic	ADJ
hls-12456	82	8	material	material	NOUN
hls-12456	82	9	is	be	AUX
hls-12456	82	10	also	also	ADV
hls-12456	82	11	polymorphic	polymorphic	ADJ
hls-12456	82	12	in	in	ADP
hls-12456	82	13	its	its	PRON
hls-12456	82	14	structure	structure	NOUN
hls-12456	82	15	,	,	PUNCT
hls-12456	82	16	ranging	range	VERB
hls-12456	82	17	from	from	ADP
hls-12456	82	18	slight	slight	ADJ
hls-12456	82	19	differences	difference	NOUN
hls-12456	82	20	in	in	ADP
hls-12456	82	21	metastatic	metastatic	ADJ
hls-12456	82	22	cell	cell	NOUN
hls-12456	82	23	populations	population	NOUN
hls-12456	82	24	to	to	ADP
hls-12456	82	25	cases	case	NOUN
hls-12456	82	26	where	where	SCONJ
hls-12456	82	27	dnaai	dnaai	VERB
hls-12456	82	28	in	in	ADP
hls-12456	82	29	a	a	DET
hls-12456	82	30	metastasis	metastasis	NOUN
hls-12456	82	31	to	to	ADP
hls-12456	82	32	a	a	DET
hls-12456	82	33	lymph	lymph	NOUN
hls-12456	82	34	node	node	NOUN
hls-12456	82	35	was	be	AUX
hls-12456	82	36	6.54	6.54	NUM
hls-12456	82	37	,	,	PUNCT
hls-12456	82	38	and	and	CCONJ
hls-12456	82	39	in	in	ADP
hls-12456	82	40	the	the	DET
hls-12456	82	41	lungs	lung	NOUN
hls-12456	82	42	–	–	PUNCT
hls-12456	82	43	25.2	25.2	NUM
hls-12456	82	44	.	.	PUNCT
hls-12456	83	1	social	social	ADJ
hls-12456	83	2	and	and	CCONJ
hls-12456	83	3	political	political	ADJ
hls-12456	83	4	factors	factor	NOUN
hls-12456	83	5	affecting	affect	VERB
hls-12456	83	6	public	public	ADJ
hls-12456	83	7	health	health	NOUN
hls-12456	84	1	[	[	X
hls-12456	84	2	healthcare	healthcare	NOUN
hls-12456	84	3	in	in	ADP
hls-12456	84	4	low	low	ADJ
hls-12456	84	5	-	-	PUNCT
hls-12456	84	6	resource	resource	NOUN
hls-12456	84	7	settings	setting	NOUN
hls-12456	84	8	2024;12(s2):12456	2024;12(s2):12456	NUM
hls-12456	84	9	]	]	PUNCT
hls-12456	85	1	[	[	X
hls-12456	85	2	page	page	NOUN
hls-12456	85	3	77	77	NUM
hls-12456	85	4	]	]	X
hls-12456	85	5	non	non	ADJ
hls-12456	85	6	-co	-co	PROPN
hls-12456	85	7	mmerc	mmerc	PROPN
hls-12456	85	8	ial	ial	PROPN
hls-12456	85	9	us	us	PROPN
hls-12456	85	10	e	e	NOUN
hls-12456	85	11	o	o	X
hls-12456	85	12	nly	nly	ADV
hls-12456	85	13	the	the	DET
hls-12456	85	14	uneven	uneven	ADJ
hls-12456	85	15	distribution	distribution	NOUN
hls-12456	85	16	of	of	ADP
hls-12456	85	17	the	the	DET
hls-12456	85	18	molecular	molecular	ADJ
hls-12456	85	19	-	-	PUNCT
hls-12456	85	20	genetic	genetic	ADJ
hls-12456	85	21	material	material	NOUN
hls-12456	85	22	can	can	AUX
hls-12456	85	23	be	be	AUX
hls-12456	85	24	attributed	attribute	VERB
hls-12456	85	25	to	to	ADP
hls-12456	85	26	several	several	ADJ
hls-12456	85	27	factors	factor	NOUN
hls-12456	85	28	.	.	PUNCT
hls-12456	86	1	firstly	firstly	ADV
hls-12456	86	2	,	,	PUNCT
hls-12456	86	3	it	it	PRON
hls-12456	86	4	may	may	AUX
hls-12456	86	5	reflect	reflect	VERB
hls-12456	86	6	the	the	DET
hls-12456	86	7	presence	presence	NOUN
hls-12456	86	8	of	of	ADP
hls-12456	86	9	different	different	ADJ
hls-12456	86	10	clones	clone	NOUN
hls-12456	86	11	of	of	ADP
hls-12456	86	12	tumor	tumor	NOUN
hls-12456	86	13	cells	cell	NOUN
hls-12456	86	14	,	,	PUNCT
hls-12456	86	15	each	each	PRON
hls-12456	86	16	with	with	ADP
hls-12456	86	17	its	its	PRON
hls-12456	86	18	unique	unique	ADJ
hls-12456	86	19	genetic	genetic	ADJ
hls-12456	86	20	profile	profile	NOUN
hls-12456	86	21	and	and	CCONJ
hls-12456	86	22	characteristics	characteristic	NOUN
hls-12456	86	23	that	that	PRON
hls-12456	86	24	influence	influence	VERB
hls-12456	86	25	their	their	PRON
hls-12456	86	26	ability	ability	NOUN
hls-12456	86	27	to	to	PART
hls-12456	86	28	metastasize	metastasize	VERB
hls-12456	86	29	and	and	CCONJ
hls-12456	86	30	grow	grow	VERB
hls-12456	86	31	.	.	PUNCT
hls-12456	87	1	this	this	DET
hls-12456	87	2	variation	variation	NOUN
hls-12456	87	3	can	can	AUX
hls-12456	87	4	be	be	AUX
hls-12456	87	5	associated	associate	VERB
hls-12456	87	6	with	with	ADP
hls-12456	87	7	the	the	DET
hls-12456	87	8	phenomenon	phenomenon	NOUN
hls-12456	87	9	of	of	ADP
hls-12456	87	10	single	single	ADJ
hls-12456	87	11	nucleotide	nucleotide	NOUN
hls-12456	87	12	polymorphism	polymorphism	NOUN
hls-12456	87	13	,	,	PUNCT
hls-12456	87	14	where	where	SCONJ
hls-12456	87	15	point	point	NOUN
hls-12456	87	16	mutations	mutation	NOUN
hls-12456	87	17	occur	occur	VERB
hls-12456	87	18	on	on	ADP
hls-12456	87	19	a	a	DET
hls-12456	87	20	nucleotide	nucleotide	ADJ
hls-12456	87	21	scale	scale	NOUN
hls-12456	87	22	,	,	PUNCT
hls-12456	87	23	leading	lead	VERB
hls-12456	87	24	to	to	ADP
hls-12456	87	25	changes	change	NOUN
hls-12456	87	26	in	in	ADP
hls-12456	87	27	the	the	DET
hls-12456	87	28	entire	entire	ADJ
hls-12456	87	29	allele	allele	NOUN
hls-12456	87	30	and	and	CCONJ
hls-12456	87	31	morpho	morpho	NOUN
hls-12456	87	32	-	-	ADJ
hls-12456	87	33	functional	functional	ADJ
hls-12456	87	34	properties	property	NOUN
hls-12456	87	35	of	of	ADP
hls-12456	87	36	the	the	DET
hls-12456	87	37	cell	cell	NOUN
hls-12456	87	38	.	.	PUNCT
hls-12456	88	1	the	the	DET
hls-12456	88	2	risk	risk	NOUN
hls-12456	88	3	of	of	ADP
hls-12456	88	4	this	this	DET
hls-12456	88	5	phenomenon	phenomenon	NOUN
hls-12456	88	6	is	be	AUX
hls-12456	88	7	directly	directly	ADV
hls-12456	88	8	proportional	proportional	ADJ
hls-12456	88	9	to	to	ADP
hls-12456	88	10	the	the	DET
hls-12456	88	11	cell	cell	NOUN
hls-12456	88	12	division	division	NOUN
hls-12456	88	13	rate	rate	NOUN
hls-12456	88	14	,	,	PUNCT
hls-12456	88	15	especially	especially	ADV
hls-12456	88	16	in	in	ADP
hls-12456	88	17	the	the	DET
hls-12456	88	18	study	study	NOUN
hls-12456	88	19	of	of	ADP
hls-12456	88	20	populations	population	NOUN
hls-12456	88	21	of	of	ADP
hls-12456	88	22	malignant	malignant	ADJ
hls-12456	88	23	cells.7	cells.7	NOUN
hls-12456	88	24	secondly	secondly	ADV
hls-12456	88	25	,	,	PUNCT
hls-12456	88	26	it	it	PRON
hls-12456	88	27	may	may	AUX
hls-12456	88	28	be	be	AUX
hls-12456	88	29	related	relate	VERB
hls-12456	88	30	to	to	ADP
hls-12456	88	31	different	different	ADJ
hls-12456	88	32	microecological	microecological	ADJ
hls-12456	88	33	conditions	condition	NOUN
hls-12456	88	34	in	in	ADP
hls-12456	88	35	the	the	DET
hls-12456	88	36	metastatic	metastatic	ADJ
hls-12456	88	37	development	development	NOUN
hls-12456	88	38	sites	site	NOUN
hls-12456	88	39	,	,	PUNCT
hls-12456	88	40	which	which	PRON
hls-12456	88	41	can	can	AUX
hls-12456	88	42	either	either	CCONJ
hls-12456	88	43	promote	promote	VERB
hls-12456	88	44	or	or	CCONJ
hls-12456	88	45	inhibit	inhibit	VERB
hls-12456	88	46	the	the	DET
hls-12456	88	47	activity	activity	NOUN
hls-12456	88	48	of	of	ADP
hls-12456	88	49	tumor	tumor	NOUN
hls-12456	88	50	cells.8	cells.8	ADJ
hls-12456	88	51	these	these	DET
hls-12456	88	52	conditions	condition	NOUN
hls-12456	88	53	include	include	VERB
hls-12456	88	54	factors	factor	NOUN
hls-12456	88	55	of	of	ADP
hls-12456	88	56	the	the	DET
hls-12456	88	57	microenvironment	microenvironment	NOUN
hls-12456	88	58	such	such	ADJ
hls-12456	88	59	as	as	ADP
hls-12456	88	60	blood	blood	NOUN
hls-12456	88	61	supply	supply	NOUN
hls-12456	88	62	,	,	PUNCT
hls-12456	88	63	oxygen	oxygen	NOUN
hls-12456	88	64	saturation	saturation	NOUN
hls-12456	88	65	,	,	PUNCT
hls-12456	88	66	and	and	CCONJ
hls-12456	88	67	the	the	DET
hls-12456	88	68	presence	presence	NOUN
hls-12456	88	69	of	of	ADP
hls-12456	88	70	inflammatory	inflammatory	ADJ
hls-12456	88	71	cells	cell	NOUN
hls-12456	88	72	,	,	PUNCT
hls-12456	88	73	which	which	PRON
hls-12456	88	74	can	can	AUX
hls-12456	88	75	affect	affect	VERB
hls-12456	88	76	the	the	DET
hls-12456	88	77	metabolic	metabolic	NOUN
hls-12456	88	78	activity	activity	NOUN
hls-12456	88	79	and	and	CCONJ
hls-12456	88	80	replicative	replicative	ADJ
hls-12456	88	81	potential	potential	NOUN
hls-12456	88	82	of	of	ADP
hls-12456	88	83	tumor	tumor	NOUN
hls-12456	88	84	cells.9,10	cells.9,10	PROPN
hls-12456	88	85	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	88	86	analysis	analysis	NOUN
hls-12456	88	87	of	of	ADP
hls-12456	88	88	the	the	DET
hls-12456	88	89	nuclei	nucleus	NOUN
hls-12456	88	90	of	of	ADP
hls-12456	88	91	tumor	tumor	NOUN
hls-12456	88	92	cells	cell	NOUN
hls-12456	88	93	in	in	ADP
hls-12456	88	94	metastases	metastasis	NOUN
hls-12456	88	95	and	and	CCONJ
hls-12456	88	96	their	their	PRON
hls-12456	88	97	comparison	comparison	NOUN
hls-12456	88	98	with	with	ADP
hls-12456	88	99	each	each	DET
hls-12456	88	100	other	other	ADJ
hls-12456	88	101	and	and	CCONJ
hls-12456	88	102	with	with	ADP
hls-12456	88	103	primary	primary	ADJ
hls-12456	88	104	tumors	tumor	NOUN
hls-12456	88	105	revealed	reveal	VERB
hls-12456	88	106	that	that	SCONJ
hls-12456	88	107	in	in	ADP
hls-12456	88	108	most	most	ADJ
hls-12456	88	109	cases	case	NOUN
hls-12456	88	110	,	,	PUNCT
hls-12456	88	111	metastases	metastasis	NOUN
hls-12456	88	112	have	have	VERB
hls-12456	88	113	distinct	distinct	ADJ
hls-12456	88	114	dnaai	dnaai	NOUN
hls-12456	88	115	,	,	PUNCT
hls-12456	88	116	except	except	SCONJ
hls-12456	88	117	for	for	ADP
hls-12456	88	118	one	one	NUM
hls-12456	88	119	case	case	NOUN
hls-12456	88	120	where	where	SCONJ
hls-12456	88	121	the	the	DET
hls-12456	88	122	liver	liver	NOUN
hls-12456	88	123	metastasis	metastasis	NOUN
hls-12456	88	124	had	have	VERB
hls-12456	88	125	dnaai=1.61	dnaai=1.61	NOUN
hls-12456	88	126	,	,	PUNCT
hls-12456	88	127	and	and	CCONJ
hls-12456	88	128	the	the	DET
hls-12456	88	129	pancreatic	pancreatic	ADJ
hls-12456	88	130	metastasis	metastasis	NOUN
hls-12456	88	131	had	have	VERB
hls-12456	88	132	dnaai=1.65	dnaai=1.65	NOUN
hls-12456	88	133	.	.	PUNCT
hls-12456	89	1	this	this	PRON
hls-12456	89	2	indicates	indicate	VERB
hls-12456	89	3	the	the	DET
hls-12456	89	4	clonal	clonal	ADJ
hls-12456	89	5	nature	nature	NOUN
hls-12456	89	6	of	of	ADP
hls-12456	89	7	metastases	metastasis	NOUN
hls-12456	89	8	,	,	PUNCT
hls-12456	89	9	characterized	characterize	VERB
hls-12456	89	10	by	by	ADP
hls-12456	89	11	variable	variable	ADJ
hls-12456	89	12	levels	level	NOUN
hls-12456	89	13	of	of	ADP
hls-12456	89	14	dna	dna	PROPN
hls-12456	89	15	synthesis	synthesis	NOUN
hls-12456	89	16	.	.	PUNCT
hls-12456	90	1	compared	compare	VERB
hls-12456	90	2	to	to	ADP
hls-12456	90	3	primary	primary	ADJ
hls-12456	90	4	tumors	tumor	NOUN
hls-12456	90	5	,	,	PUNCT
hls-12456	90	6	metastases	metastasis	NOUN
hls-12456	90	7	had	have	VERB
hls-12456	90	8	a	a	DET
hls-12456	90	9	higher	high	ADJ
hls-12456	90	10	dnaai	dnaai	NOUN
hls-12456	90	11	in	in	ADP
hls-12456	90	12	55.2	55.2	NUM
hls-12456	90	13	%	%	NOUN
hls-12456	90	14	of	of	ADP
hls-12456	90	15	cases	case	NOUN
hls-12456	90	16	,	,	PUNCT
hls-12456	90	17	lower	low	ADJ
hls-12456	90	18	in	in	ADP
hls-12456	90	19	41.4	41.4	NUM
hls-12456	90	20	%	%	NOUN
hls-12456	90	21	,	,	PUNCT
hls-12456	90	22	and	and	CCONJ
hls-12456	90	23	equal	equal	ADJ
hls-12456	90	24	in	in	ADP
hls-12456	90	25	3.4	3.4	NUM
hls-12456	90	26	%	%	NOUN
hls-12456	90	27	,	,	PUNCT
hls-12456	90	28	as	as	SCONJ
hls-12456	90	29	demonstrated	demonstrate	VERB
hls-12456	90	30	in	in	ADP
hls-12456	90	31	tables	table	NOUN
hls-12456	90	32	1	1	NUM
hls-12456	90	33	and	and	CCONJ
hls-12456	90	34	2	2	NUM
hls-12456	90	35	.	.	PUNCT
hls-12456	90	36	metastatic	metastatic	ADJ
hls-12456	90	37	cell	cell	NOUN
hls-12456	90	38	populations	population	NOUN
hls-12456	90	39	also	also	ADV
hls-12456	90	40	showed	show	VERB
hls-12456	90	41	a	a	DET
hls-12456	90	42	tendency	tendency	NOUN
hls-12456	90	43	to	to	PART
hls-12456	90	44	increase	increase	VERB
hls-12456	90	45	nuclear	nuclear	ADJ
hls-12456	90	46	diameter	diameter	NOUN
hls-12456	90	47	and	and	CCONJ
hls-12456	90	48	dna	dna	NOUN
hls-12456	90	49	quantity	quantity	NOUN
hls-12456	90	50	compared	compare	VERB
hls-12456	90	51	to	to	ADP
hls-12456	90	52	primary	primary	ADJ
hls-12456	90	53	tumors	tumor	NOUN
hls-12456	90	54	,	,	PUNCT
hls-12456	90	55	indicating	indicate	VERB
hls-12456	90	56	a	a	DET
hls-12456	90	57	prevalence	prevalence	NOUN
hls-12456	90	58	of	of	ADP
hls-12456	90	59	poorly	poorly	ADV
hls-12456	90	60	differentiated	differentiate	VERB
hls-12456	90	61	,	,	PUNCT
hls-12456	90	62	heteroand	heteroand	ADJ
hls-12456	90	63	polyploid	polyploid	ADJ
hls-12456	90	64	cells	cell	NOUN
hls-12456	90	65	.	.	PUNCT
hls-12456	91	1	information	information	NOUN
hls-12456	91	2	on	on	ADP
hls-12456	91	3	the	the	DET
hls-12456	91	4	distribution	distribution	NOUN
hls-12456	91	5	of	of	ADP
hls-12456	91	6	nuclear	nuclear	ADJ
hls-12456	91	7	diameter	diameter	NOUN
hls-12456	91	8	among	among	ADP
hls-12456	91	9	different	different	ADJ
hls-12456	91	10	cell	cell	NOUN
hls-12456	91	11	groups	group	NOUN
hls-12456	91	12	is	be	AUX
hls-12456	91	13	presented	present	VERB
hls-12456	91	14	in	in	ADP
hls-12456	91	15	table	table	NOUN
hls-12456	91	16	1	1	NUM
hls-12456	91	17	.	.	PUNCT
hls-12456	92	1	the	the	DET
hls-12456	92	2	above	above	ADJ
hls-12456	92	3	suggests	suggest	VERB
hls-12456	92	4	a	a	DET
hls-12456	92	5	tendency	tendency	NOUN
hls-12456	92	6	to	to	PART
hls-12456	92	7	select	select	VERB
hls-12456	92	8	less	less	ADV
hls-12456	92	9	differentiated	differentiated	ADJ
hls-12456	92	10	cells	cell	NOUN
hls-12456	92	11	during	during	ADP
hls-12456	92	12	the	the	DET
hls-12456	92	13	process	process	NOUN
hls-12456	92	14	of	of	ADP
hls-12456	92	15	metastasis	metastasis	NOUN
hls-12456	92	16	than	than	ADP
hls-12456	92	17	in	in	ADP
hls-12456	92	18	the	the	DET
hls-12456	92	19	primary	primary	ADJ
hls-12456	92	20	population	population	NOUN
hls-12456	92	21	of	of	ADP
hls-12456	92	22	cells	cell	NOUN
hls-12456	92	23	.	.	PUNCT
hls-12456	93	1	however	however	ADV
hls-12456	93	2	,	,	PUNCT
hls-12456	93	3	in	in	ADP
hls-12456	93	4	some	some	DET
hls-12456	93	5	metastatic	metastatic	ADJ
hls-12456	93	6	nodes	node	NOUN
hls-12456	93	7	,	,	PUNCT
hls-12456	93	8	the	the	DET
hls-12456	93	9	opposite	opposite	ADJ
hls-12456	93	10	trend	trend	NOUN
hls-12456	93	11	was	be	AUX
hls-12456	93	12	observed	observe	VERB
hls-12456	93	13	,	,	PUNCT
hls-12456	93	14	with	with	ADP
hls-12456	93	15	signs	sign	NOUN
hls-12456	93	16	of	of	ADP
hls-12456	93	17	increased	increase	VERB
hls-12456	93	18	cell	cell	NOUN
hls-12456	93	19	differentiation	differentiation	NOUN
hls-12456	93	20	.	.	PUNCT
hls-12456	94	1	since	since	SCONJ
hls-12456	94	2	metastasis	metastasis	NOUN
hls-12456	94	3	was	be	AUX
hls-12456	94	4	detected	detect	VERB
hls-12456	94	5	in	in	ADP
hls-12456	94	6	the	the	DET
hls-12456	94	7	liver	liver	NOUN
hls-12456	94	8	in	in	ADP
hls-12456	94	9	most	most	ADJ
hls-12456	94	10	cases	case	NOUN
hls-12456	94	11	,	,	PUNCT
hls-12456	94	12	questions	question	NOUN
hls-12456	94	13	have	have	AUX
hls-12456	94	14	arisen	arise	VERB
hls-12456	94	15	regarding	regard	VERB
hls-12456	94	16	the	the	DET
hls-12456	94	17	influence	influence	NOUN
hls-12456	94	18	of	of	ADP
hls-12456	94	19	the	the	DET
hls-12456	94	20	target	target	NOUN
hls-12456	94	21	organ	organ	VERB
hls-12456	94	22	on	on	ADP
hls-12456	94	23	the	the	DET
hls-12456	94	24	dna	dna	PROPN
hls-12456	94	25	synthesis	synthesis	NOUN
hls-12456	94	26	process	process	NOUN
hls-12456	94	27	in	in	ADP
hls-12456	94	28	metastatic	metastatic	ADJ
hls-12456	94	29	cell	cell	NOUN
hls-12456	94	30	populations	population	NOUN
hls-12456	94	31	.	.	PUNCT
hls-12456	95	1	the	the	DET
hls-12456	95	2	analysis	analysis	NOUN
hls-12456	95	3	showed	show	VERB
hls-12456	95	4	that	that	SCONJ
hls-12456	95	5	44.4	44.4	NUM
hls-12456	95	6	%	%	NOUN
hls-12456	95	7	of	of	ADP
hls-12456	95	8	liver	liver	NOUN
hls-12456	95	9	metastases	metastasis	NOUN
hls-12456	95	10	had	have	VERB
hls-12456	95	11	a	a	DET
hls-12456	95	12	higher	high	ADJ
hls-12456	95	13	dnaai	dnaai	NOUN
hls-12456	95	14	,	,	PUNCT
hls-12456	95	15	44.4	44.4	NUM
hls-12456	95	16	%	%	NOUN
hls-12456	95	17	had	have	VERB
hls-12456	95	18	a	a	DET
hls-12456	95	19	lower	low	ADJ
hls-12456	95	20	dnaai	dnaai	NOUN
hls-12456	95	21	,	,	PUNCT
hls-12456	95	22	and	and	CCONJ
hls-12456	95	23	11.2	11.2	NUM
hls-12456	95	24	%	%	NOUN
hls-12456	95	25	had	have	VERB
hls-12456	95	26	a	a	DET
hls-12456	95	27	similar	similar	ADJ
hls-12456	95	28	dnaai	dnaai	NOUN
hls-12456	95	29	to	to	ADP
hls-12456	95	30	the	the	DET
hls-12456	95	31	primary	primary	ADJ
hls-12456	95	32	tumor	tumor	NOUN
hls-12456	95	33	cell	cell	NOUN
hls-12456	95	34	population	population	NOUN
hls-12456	95	35	.	.	PUNCT
hls-12456	96	1	this	this	PRON
hls-12456	96	2	indicates	indicate	VERB
hls-12456	96	3	the	the	DET
hls-12456	96	4	relative	relative	ADJ
hls-12456	96	5	autonomy	autonomy	NOUN
hls-12456	96	6	of	of	ADP
hls-12456	96	7	tumor	tumor	NOUN
hls-12456	96	8	cells	cell	NOUN
hls-12456	96	9	from	from	ADP
hls-12456	96	10	the	the	DET
hls-12456	96	11	target	target	NOUN
hls-12456	96	12	organ	organ	NOUN
hls-12456	96	13	,	,	PUNCT
hls-12456	96	14	as	as	SCONJ
hls-12456	96	15	intracellular	intracellular	ADJ
hls-12456	96	16	synthesis	synthesis	NOUN
hls-12456	96	17	is	be	AUX
hls-12456	96	18	genetically	genetically	ADV
hls-12456	96	19	determined.11	determined.11	VERB
hls-12456	96	20	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	96	21	analysis	analysis	NOUN
hls-12456	96	22	to	to	PART
hls-12456	96	23	determine	determine	VERB
hls-12456	96	24	rna	rna	NOUN
hls-12456	96	25	levels	level	NOUN
hls-12456	96	26	in	in	ADP
hls-12456	96	27	the	the	DET
hls-12456	96	28	cytoplasm	cytoplasm	NOUN
hls-12456	96	29	and	and	CCONJ
hls-12456	96	30	nucleus	nucleus	NOUN
hls-12456	96	31	of	of	ADP
hls-12456	96	32	tumor	tumor	NOUN
hls-12456	96	33	cells	cell	NOUN
hls-12456	96	34	demonstrated	demonstrate	VERB
hls-12456	96	35	significant	significant	ADJ
hls-12456	96	36	variability	variability	NOUN
hls-12456	96	37	in	in	ADP
hls-12456	96	38	results	result	NOUN
hls-12456	96	39	,	,	PUNCT
hls-12456	96	40	with	with	ADP
hls-12456	96	41	no	no	DET
hls-12456	96	42	clear	clear	ADJ
hls-12456	96	43	correlation	correlation	NOUN
hls-12456	96	44	with	with	ADP
hls-12456	96	45	changes	change	NOUN
hls-12456	96	46	in	in	ADP
hls-12456	96	47	dna	dna	PROPN
hls-12456	96	48	quantity	quantity	NOUN
hls-12456	96	49	in	in	ADP
hls-12456	96	50	cells	cell	NOUN
hls-12456	96	51	or	or	CCONJ
hls-12456	96	52	among	among	ADP
hls-12456	96	53	themselves	themselves	PRON
hls-12456	96	54	.	.	PUNCT
hls-12456	97	1	the	the	DET
hls-12456	97	2	results	result	NOUN
hls-12456	97	3	,	,	PUNCT
hls-12456	97	4	as	as	SCONJ
hls-12456	97	5	shown	show	VERB
hls-12456	97	6	in	in	ADP
hls-12456	97	7	table	table	NOUN
hls-12456	97	8	2	2	NUM
hls-12456	97	9	,	,	PUNCT
hls-12456	97	10	revealed	reveal	VERB
hls-12456	97	11	a	a	DET
hls-12456	97	12	tendency	tendency	NOUN
hls-12456	97	13	to	to	PART
hls-12456	97	14	decrease	decrease	VERB
hls-12456	97	15	the	the	DET
hls-12456	97	16	concentration	concentration	NOUN
hls-12456	97	17	of	of	ADP
hls-12456	97	18	nuclear	nuclear	ADJ
hls-12456	97	19	rna	rna	NOUN
hls-12456	97	20	and	and	CCONJ
hls-12456	97	21	increase	increase	VERB
hls-12456	97	22	cytoplasmic	cytoplasmic	ADJ
hls-12456	97	23	rna	rna	NOUN
hls-12456	97	24	levels	level	NOUN
hls-12456	97	25	in	in	ADP
hls-12456	97	26	metastatic	metastatic	ADJ
hls-12456	97	27	cells	cell	NOUN
hls-12456	97	28	,	,	PUNCT
hls-12456	97	29	accounting	account	VERB
hls-12456	97	30	for	for	ADP
hls-12456	97	31	53.3	53.3	NUM
hls-12456	97	32	%	%	NOUN
hls-12456	97	33	and	and	CCONJ
hls-12456	97	34	56.6	56.6	NUM
hls-12456	97	35	%	%	NOUN
hls-12456	97	36	,	,	PUNCT
hls-12456	97	37	respectively	respectively	ADV
hls-12456	97	38	.	.	PUNCT
hls-12456	98	1	these	these	DET
hls-12456	98	2	results	result	NOUN
hls-12456	98	3	suggest	suggest	VERB
hls-12456	98	4	that	that	SCONJ
hls-12456	98	5	metastatic	metastatic	ADJ
hls-12456	98	6	cells	cell	NOUN
hls-12456	98	7	often	often	ADV
hls-12456	98	8	exhibit	exhibit	VERB
hls-12456	98	9	an	an	DET
hls-12456	98	10	increase	increase	NOUN
hls-12456	98	11	in	in	ADP
hls-12456	98	12	dna	dna	PROPN
hls-12456	98	13	quantity	quantity	NOUN
hls-12456	98	14	,	,	PUNCT
hls-12456	98	15	which	which	PRON
hls-12456	98	16	is	be	AUX
hls-12456	98	17	inversely	inversely	ADV
hls-12456	98	18	proportional	proportional	ADJ
hls-12456	98	19	to	to	ADP
hls-12456	98	20	rna	rna	NOUN
hls-12456	98	21	levels	level	NOUN
hls-12456	98	22	.	.	PUNCT
hls-12456	99	1	in	in	ADP
hls-12456	99	2	36.6	36.6	NUM
hls-12456	99	3	%	%	NOUN
hls-12456	99	4	of	of	ADP
hls-12456	99	5	cases	case	NOUN
hls-12456	99	6	,	,	PUNCT
hls-12456	99	7	the	the	DET
hls-12456	99	8	metastasis	metastasis	NOUN
hls-12456	99	9	process	process	NOUN
hls-12456	99	10	was	be	AUX
hls-12456	99	11	accompanied	accompany	VERB
hls-12456	99	12	by	by	ADP
hls-12456	99	13	a	a	DET
hls-12456	99	14	decrease	decrease	NOUN
hls-12456	99	15	in	in	ADP
hls-12456	99	16	nuclear	nuclear	ADJ
hls-12456	99	17	rna	rna	NOUN
hls-12456	99	18	concentration	concentration	NOUN
hls-12456	99	19	.	.	PUNCT
hls-12456	100	1	simultaneously	simultaneously	ADV
hls-12456	100	2	,	,	PUNCT
hls-12456	100	3	an	an	DET
hls-12456	100	4	increase	increase	NOUN
hls-12456	100	5	in	in	ADP
hls-12456	100	6	cytoplasmic	cytoplasmic	ADJ
hls-12456	100	7	rna	rna	NOUN
hls-12456	100	8	was	be	AUX
hls-12456	100	9	observed	observe	VERB
hls-12456	100	10	in	in	ADP
hls-12456	100	11	30	30	NUM
hls-12456	100	12	%	%	NOUN
hls-12456	100	13	of	of	ADP
hls-12456	100	14	cases	case	NOUN
hls-12456	100	15	.	.	PUNCT
hls-12456	101	1	thus	thus	ADV
hls-12456	101	2	,	,	PUNCT
hls-12456	101	3	the	the	DET
hls-12456	101	4	correlation	correlation	NOUN
hls-12456	101	5	between	between	ADP
hls-12456	101	6	dna	dna	PROPN
hls-12456	101	7	and	and	CCONJ
hls-12456	101	8	rna	rna	NOUN
hls-12456	101	9	levels	level	NOUN
hls-12456	101	10	had	have	VERB
hls-12456	101	11	some	some	DET
hls-12456	101	12	polymorphism	polymorphism	NOUN
hls-12456	101	13	depending	depend	VERB
hls-12456	101	14	on	on	ADP
hls-12456	101	15	the	the	DET
hls-12456	101	16	type	type	NOUN
hls-12456	101	17	of	of	ADP
hls-12456	101	18	rna	rna	NOUN
hls-12456	101	19	.	.	PUNCT
hls-12456	102	1	it	it	PRON
hls-12456	102	2	is	be	AUX
hls-12456	102	3	also	also	ADV
hls-12456	102	4	important	important	ADJ
hls-12456	102	5	to	to	PART
hls-12456	102	6	note	note	VERB
hls-12456	102	7	that	that	SCONJ
hls-12456	102	8	the	the	DET
hls-12456	102	9	correlation	correlation	NOUN
hls-12456	102	10	coefficient	coefficient	NOUN
hls-12456	102	11	in	in	ADP
hls-12456	102	12	these	these	DET
hls-12456	102	13	cases	case	NOUN
hls-12456	102	14	remained	remain	VERB
hls-12456	102	15	low	low	ADJ
hls-12456	102	16	(	(	PUNCT
hls-12456	102	17	r<0.3	r<0.3	PROPN
hls-12456	102	18	)	)	PUNCT
hls-12456	102	19	.	.	PUNCT
hls-12456	103	1	the	the	DET
hls-12456	103	2	concentration	concentration	NOUN
hls-12456	103	3	of	of	ADP
hls-12456	103	4	rna	rna	NOUN
hls-12456	103	5	,	,	PUNCT
hls-12456	103	6	both	both	CCONJ
hls-12456	103	7	in	in	ADP
hls-12456	103	8	the	the	DET
hls-12456	103	9	cytoplasm	cytoplasm	NOUN
hls-12456	103	10	and	and	CCONJ
hls-12456	103	11	in	in	ADP
hls-12456	103	12	the	the	DET
hls-12456	103	13	nucleus	nucleus	NOUN
hls-12456	103	14	(	(	PUNCT
hls-12456	103	15	especially	especially	ADV
hls-12456	103	16	in	in	ADP
hls-12456	103	17	the	the	DET
hls-12456	103	18	nucleolus	nucleolus	NOUN
hls-12456	103	19	)	)	PUNCT
hls-12456	103	20	,	,	PUNCT
hls-12456	103	21	reflects	reflect	VERB
hls-12456	103	22	the	the	DET
hls-12456	103	23	functional	functional	ADJ
hls-12456	103	24	activity	activity	NOUN
hls-12456	103	25	of	of	ADP
hls-12456	103	26	cells	cell	NOUN
hls-12456	103	27	,	,	PUNCT
hls-12456	103	28	especially	especially	ADV
hls-12456	103	29	long	long	ADJ
hls-12456	103	30	non	non	ADJ
hls-12456	103	31	-	-	ADJ
hls-12456	103	32	coding	coding	ADJ
hls-12456	103	33	rnas	rna	NOUN
hls-12456	103	34	(	(	PUNCT
hls-12456	103	35	lncrnas	lncrnas	PROPN
hls-12456	103	36	)	)	PUNCT
hls-12456	103	37	,	,	PUNCT
hls-12456	103	38	which	which	PRON
hls-12456	103	39	regulate	regulate	VERB
hls-12456	103	40	a	a	DET
hls-12456	103	41	wide	wide	ADJ
hls-12456	103	42	range	range	NOUN
hls-12456	103	43	of	of	ADP
hls-12456	103	44	intracellular	intracellular	ADJ
hls-12456	103	45	metabolic	metabolic	NOUN
hls-12456	103	46	processes.12,13	processes.12,13	NOUN
hls-12456	103	47	based	base	VERB
hls-12456	103	48	on	on	ADP
hls-12456	103	49	the	the	DET
hls-12456	103	50	analysis	analysis	NOUN
hls-12456	103	51	of	of	ADP
hls-12456	103	52	the	the	DET
hls-12456	103	53	collected	collect	VERB
hls-12456	103	54	data	datum	NOUN
hls-12456	103	55	,	,	PUNCT
hls-12456	103	56	it	it	PRON
hls-12456	103	57	can	can	AUX
hls-12456	103	58	be	be	AUX
hls-12456	103	59	stated	state	VERB
hls-12456	103	60	that	that	SCONJ
hls-12456	103	61	establishing	establish	VERB
hls-12456	103	62	a	a	DET
hls-12456	103	63	clear	clear	ADJ
hls-12456	103	64	relationship	relationship	NOUN
hls-12456	103	65	between	between	ADP
hls-12456	103	66	changes	change	NOUN
hls-12456	103	67	in	in	ADP
hls-12456	103	68	dna	dna	PROPN
hls-12456	103	69	and	and	CCONJ
hls-12456	103	70	rna	rna	NOUN
hls-12456	103	71	concentrations	concentration	NOUN
hls-12456	103	72	in	in	ADP
hls-12456	103	73	tumor	tumor	NOUN
hls-12456	103	74	cells	cell	NOUN
hls-12456	103	75	is	be	AUX
hls-12456	103	76	not	not	PART
hls-12456	103	77	possible	possible	ADJ
hls-12456	103	78	.	.	PUNCT
hls-12456	104	1	the	the	DET
hls-12456	104	2	absence	absence	NOUN
hls-12456	104	3	of	of	ADP
hls-12456	104	4	a	a	DET
hls-12456	104	5	clear	clear	ADJ
hls-12456	104	6	interaction	interaction	NOUN
hls-12456	104	7	may	may	AUX
hls-12456	104	8	indicate	indicate	VERB
hls-12456	104	9	the	the	DET
hls-12456	104	10	presence	presence	NOUN
hls-12456	104	11	of	of	ADP
hls-12456	104	12	noticeable	noticeable	ADJ
hls-12456	104	13	polymorphism	polymorphism	NOUN
hls-12456	104	14	and	and	CCONJ
hls-12456	104	15	significant	significant	ADJ
hls-12456	104	16	functional	functional	ADJ
hls-12456	104	17	diversity	diversity	NOUN
hls-12456	104	18	in	in	ADP
hls-12456	104	19	both	both	CCONJ
hls-12456	104	20	primary	primary	ADJ
hls-12456	104	21	tumor	tumor	NOUN
hls-12456	104	22	cell	cell	NOUN
hls-12456	104	23	populations	population	NOUN
hls-12456	104	24	and	and	CCONJ
hls-12456	104	25	their	their	PRON
hls-12456	104	26	metastases	metastasis	NOUN
hls-12456	104	27	.	.	PUNCT
hls-12456	105	1	when	when	SCONJ
hls-12456	105	2	the	the	DET
hls-12456	105	3	concentration	concentration	NOUN
hls-12456	105	4	of	of	ADP
hls-12456	105	5	one	one	NUM
hls-12456	105	6	molecule	molecule	NOUN
hls-12456	105	7	changes	change	NOUN
hls-12456	105	8	,	,	PUNCT
hls-12456	105	9	it	it	PRON
hls-12456	105	10	does	do	AUX
hls-12456	105	11	not	not	PART
hls-12456	105	12	necessarily	necessarily	ADV
hls-12456	105	13	coincide	coincide	VERB
hls-12456	105	14	with	with	ADP
hls-12456	105	15	a	a	DET
hls-12456	105	16	similar	similar	ADJ
hls-12456	105	17	change	change	NOUN
hls-12456	105	18	in	in	ADP
hls-12456	105	19	another	another	PRON
hls-12456	105	20	,	,	PUNCT
hls-12456	105	21	demonstrating	demonstrate	VERB
hls-12456	105	22	the	the	DET
hls-12456	105	23	complexity	complexity	NOUN
hls-12456	105	24	of	of	ADP
hls-12456	105	25	interactions	interaction	NOUN
hls-12456	105	26	between	between	ADP
hls-12456	105	27	different	different	ADJ
hls-12456	105	28	molecular	molecular	ADJ
hls-12456	105	29	-	-	PUNCT
hls-12456	105	30	genetic	genetic	ADJ
hls-12456	105	31	components	component	NOUN
hls-12456	105	32	of	of	ADP
hls-12456	105	33	tumor	tumor	NOUN
hls-12456	105	34	cells	cell	NOUN
hls-12456	105	35	.	.	PUNCT
hls-12456	106	1	additional	additional	ADJ
hls-12456	106	2	investigation	investigation	NOUN
hls-12456	106	3	of	of	ADP
hls-12456	106	4	the	the	DET
hls-12456	106	5	nuclear	nuclear	ADJ
hls-12456	106	6	-	-	PUNCT
hls-12456	106	7	cytoplasmic	cytoplasmic	ADJ
hls-12456	106	8	index	index	NOUN
hls-12456	106	9	(	(	PUNCT
hls-12456	106	10	nci	nci	PROPN
hls-12456	106	11	)	)	PUNCT
hls-12456	106	12	in	in	ADP
hls-12456	106	13	the	the	DET
hls-12456	106	14	metastatic	metastatic	ADJ
hls-12456	106	15	cell	cell	NOUN
hls-12456	106	16	population	population	NOUN
hls-12456	106	17	and	and	CCONJ
hls-12456	106	18	its	its	PRON
hls-12456	106	19	comparison	comparison	NOUN
hls-12456	106	20	with	with	ADP
hls-12456	106	21	nci	nci	PROPN
hls-12456	106	22	in	in	ADP
hls-12456	106	23	primary	primary	ADJ
hls-12456	106	24	tumor	tumor	NOUN
hls-12456	106	25	cells	cell	NOUN
hls-12456	106	26	,	,	PUNCT
hls-12456	106	27	as	as	ADV
hls-12456	106	28	well	well	ADV
hls-12456	106	29	as	as	ADP
hls-12456	106	30	with	with	ADP
hls-12456	106	31	cytoplasmic	cytoplasmic	ADJ
hls-12456	106	32	rna	rna	NOUN
hls-12456	106	33	levels	level	NOUN
hls-12456	106	34	in	in	ADP
hls-12456	106	35	metastases	metastasis	NOUN
hls-12456	106	36	,	,	PUNCT
hls-12456	106	37	revealed	reveal	VERB
hls-12456	106	38	that	that	SCONJ
hls-12456	106	39	in	in	ADP
hls-12456	106	40	approximately	approximately	ADV
hls-12456	106	41	half	half	NOUN
hls-12456	106	42	of	of	ADP
hls-12456	106	43	the	the	DET
hls-12456	106	44	cases	case	NOUN
hls-12456	106	45	social	social	ADJ
hls-12456	106	46	and	and	CCONJ
hls-12456	106	47	political	political	ADJ
hls-12456	106	48	factors	factor	NOUN
hls-12456	106	49	affecting	affect	VERB
hls-12456	106	50	public	public	ADJ
hls-12456	106	51	health	health	NOUN
hls-12456	107	1	[	[	X
hls-12456	107	2	page	page	NOUN
hls-12456	107	3	78	78	NUM
hls-12456	107	4	]	]	PUNCT
hls-12456	108	1	[	[	X
hls-12456	108	2	healthcare	healthcare	NOUN
hls-12456	108	3	in	in	ADP
hls-12456	108	4	low	low	ADJ
hls-12456	108	5	-	-	PUNCT
hls-12456	108	6	resource	resource	NOUN
hls-12456	108	7	settings	setting	NOUN
hls-12456	108	8	2024;12(s2):12456	2024;12(s2):12456	NUM
hls-12456	108	9	]	]	PUNCT
hls-12456	108	10	table	table	NOUN
hls-12456	108	11	1	1	NUM
hls-12456	108	12	.	.	PUNCT
hls-12456	109	1	the	the	DET
hls-12456	109	2	amount	amount	NOUN
hls-12456	109	3	of	of	ADP
hls-12456	109	4	dna	dna	NOUN
hls-12456	109	5	in	in	ADP
hls-12456	109	6	metastases	metastasis	NOUN
hls-12456	109	7	cells	cell	NOUN
hls-12456	109	8	compared	compare	VERB
hls-12456	109	9	to	to	ADP
hls-12456	109	10	that	that	PRON
hls-12456	109	11	in	in	ADP
hls-12456	109	12	primary	primary	ADJ
hls-12456	109	13	tumor	tumor	NOUN
hls-12456	109	14	cells	cell	NOUN
hls-12456	109	15	.	.	PUNCT
hls-12456	110	1	indexes	index	NOUN
hls-12456	110	2	the	the	DET
hls-12456	110	3	amount	amount	NOUN
hls-12456	110	4	of	of	ADP
hls-12456	110	5	dna	dna	NOUN
hls-12456	110	6	in	in	ADP
hls-12456	110	7	metastases	metastasis	NOUN
hls-12456	110	8	compared	compare	VERB
hls-12456	110	9	to	to	ADP
hls-12456	110	10	the	the	DET
hls-12456	110	11	primary	primary	ADJ
hls-12456	110	12	tumor	tumor	NOUN
hls-12456	110	13	r	r	NOUN
hls-12456	110	14	bigger	bigger	ADV
hls-12456	110	15	smaller	smaller	ADV
hls-12456	110	16	equal	equal	ADJ
hls-12456	110	17	the	the	DET
hls-12456	110	18	average	average	ADJ
hls-12456	110	19	diameter	diameter	NOUN
hls-12456	110	20	of	of	ADP
hls-12456	110	21	the	the	DET
hls-12456	110	22	nuclei	nucleus	NOUN
hls-12456	110	23	48.3	48.3	NUM
hls-12456	110	24	41.4	41.4	NUM
hls-12456	110	25	10.3	10.3	NUM
hls-12456	110	26	0.1	0.1	NUM
hls-12456	111	1	the	the	DET
hls-12456	111	2	coefficient	coefficient	NOUN
hls-12456	111	3	of	of	ADP
hls-12456	111	4	variation	variation	NOUN
hls-12456	111	5	of	of	ADP
hls-12456	111	6	the	the	DET
hls-12456	111	7	diameter	diameter	NOUN
hls-12456	111	8	of	of	ADP
hls-12456	111	9	tumor	tumor	NOUN
hls-12456	111	10	cell	cell	NOUN
hls-12456	111	11	nuclei	nuclei	VERB
hls-12456	111	12	53.3	53.3	NUM
hls-12456	111	13	26.7	26.7	NUM
hls-12456	111	14	20	20	NUM
hls-12456	111	15	0.3	0.3	NUM
hls-12456	111	16	dna	dna	PROPN
hls-12456	111	17	concentration	concentration	NOUN
hls-12456	111	18	34.5	34.5	NUM
hls-12456	111	19	55.2	55.2	NUM
hls-12456	111	20	10.3	10.3	NUM
hls-12456	111	21	0.3	0.3	NUM
hls-12456	111	22	dna	dna	PROPN
hls-12456	111	23	accumulation	accumulation	NOUN
hls-12456	111	24	index	index	NOUN
hls-12456	111	25	55.2	55.2	NUM
hls-12456	111	26	41.4	41.4	NUM
hls-12456	111	27	3.4	3.4	NUM
hls-12456	111	28	0.3	0.3	NUM
hls-12456	111	29	source	source	NOUN
hls-12456	111	30	:	:	PUNCT
hls-12456	111	31	created	create	VERB
hls-12456	111	32	by	by	ADP
hls-12456	111	33	the	the	DET
hls-12456	111	34	authors	author	NOUN
hls-12456	111	35	.	.	PUNCT
hls-12456	112	1	table	table	NOUN
hls-12456	112	2	2	2	NUM
hls-12456	112	3	.	.	PUNCT
hls-12456	113	1	the	the	DET
hls-12456	113	2	amount	amount	NOUN
hls-12456	113	3	of	of	ADP
hls-12456	113	4	rna	rna	NOUN
hls-12456	113	5	in	in	ADP
hls-12456	113	6	the	the	DET
hls-12456	113	7	cells	cell	NOUN
hls-12456	113	8	of	of	ADP
hls-12456	113	9	metastases	metastasis	NOUN
hls-12456	113	10	compared	compare	VERB
hls-12456	113	11	to	to	ADP
hls-12456	113	12	the	the	DET
hls-12456	113	13	cells	cell	NOUN
hls-12456	113	14	of	of	ADP
hls-12456	113	15	the	the	DET
hls-12456	113	16	primary	primary	ADJ
hls-12456	113	17	tumor	tumor	NOUN
hls-12456	113	18	,	,	PUNCT
hls-12456	113	19	depending	depend	VERB
hls-12456	113	20	on	on	ADP
hls-12456	113	21	their	their	PRON
hls-12456	113	22	dnaai	dnaai	ADJ
hls-12456	113	23	parameters	parameter	NOUN
hls-12456	113	24	(	(	PUNCT
hls-12456	113	25	number	number	NOUN
hls-12456	113	26	of	of	ADP
hls-12456	113	27	observations/%	observations/%	ADJ
hls-12456	113	28	)	)	PUNCT
hls-12456	113	29	.	.	PUNCT
hls-12456	114	1	dnaai	dnaai	VERB
hls-12456	114	2	bigger	bigger	ADV
hls-12456	114	3	smaller	small	ADJ
hls-12456	114	4	equal	equal	ADJ
hls-12456	114	5	the	the	DET
hls-12456	114	6	amount	amount	NOUN
hls-12456	114	7	of	of	ADP
hls-12456	114	8	rna	rna	NOUN
hls-12456	114	9	in	in	ADP
hls-12456	114	10	metastases	metastasis	NOUN
hls-12456	114	11	compared	compare	VERB
hls-12456	114	12	to	to	ADP
hls-12456	114	13	the	the	DET
hls-12456	114	14	primary	primary	ADJ
hls-12456	114	15	tumor	tumor	NOUN
hls-12456	114	16	bigger	big	ADJ
hls-12456	114	17	smaller	small	ADJ
hls-12456	114	18	equal	equal	ADJ
hls-12456	114	19	bigger	big	ADJ
hls-12456	114	20	smaller	small	ADJ
hls-12456	114	21	equal	equal	ADJ
hls-12456	114	22	bigger	big	ADJ
hls-12456	114	23	smaller	small	ADJ
hls-12456	114	24	equal	equal	ADJ
hls-12456	114	25	concentration	concentration	NOUN
hls-12456	114	26	of	of	ADP
hls-12456	114	27	rna	rna	NOUN
hls-12456	114	28	in	in	ADP
hls-12456	114	29	the	the	DET
hls-12456	114	30	nucleus	nucleus	NOUN
hls-12456	114	31	of	of	ADP
hls-12456	114	32	tumor	tumor	NOUN
hls-12456	114	33	cells	cell	NOUN
hls-12456	114	34	5/6.7	5/6.7	NUM
hls-12456	114	35	11/6.7	11/6.7	NUM
hls-12456	114	36	2/16.6	2/16.6	NUM
hls-12456	115	1	5/16.6	5/16.6	NUM
hls-12456	115	2	5/3.4	5/3.4	NUM
hls-12456	115	3	1/3.4	1/3.4	NUM
hls-12456	115	4	1/3.4	1/3.4	NUM
hls-12456	115	5	0	0	NUM
hls-12456	115	6	0	0	NUM
hls-12456	115	7	concentration	concentration	NOUN
hls-12456	115	8	of	of	ADP
hls-12456	115	9	rna	rna	NOUN
hls-12456	115	10	in	in	ADP
hls-12456	115	11	the	the	DET
hls-12456	115	12	cytoplasm	cytoplasm	NOUN
hls-12456	115	13	of	of	ADP
hls-12456	115	14	tumor	tumor	NOUN
hls-12456	115	15	cells	cell	NOUN
hls-12456	115	16	9/30	9/30	NUM
hls-12456	115	17	4/13.3	4/13.3	NUM
hls-12456	115	18	4/13.3	4/13.3	NUM
hls-12456	115	19	8/26.6	8/26.6	NOUN
hls-12456	115	20	2/6.7	2/6.7	NUM
hls-12456	115	21	2/6.7	2/6.7	NUM
hls-12456	116	1	0	0	NUM
hls-12456	116	2	0	0	NUM
hls-12456	116	3	1/3.4	1/3.4	NUM
hls-12456	116	4	source	source	NOUN
hls-12456	116	5	:	:	PUNCT
hls-12456	116	6	created	create	VERB
hls-12456	116	7	by	by	ADP
hls-12456	116	8	the	the	DET
hls-12456	116	9	authors	author	NOUN
hls-12456	116	10	.	.	PUNCT
hls-12456	117	1	non	non	ADJ
hls-12456	118	1	-co	-co	PROPN
hls-12456	118	2	mmerc	mmerc	PROPN
hls-12456	118	3	ial	ial	PROPN
hls-12456	118	4	us	us	PROPN
hls-12456	118	5	e	e	NOUN
hls-12456	118	6	o	o	NOUN
hls-12456	118	7	nly	nly	ADV
hls-12456	118	8	(	(	PUNCT
hls-12456	118	9	46.7	46.7	NUM
hls-12456	118	10	%	%	NOUN
hls-12456	118	11	)	)	PUNCT
hls-12456	118	12	,	,	PUNCT
hls-12456	118	13	an	an	DET
hls-12456	118	14	increase	increase	NOUN
hls-12456	118	15	in	in	ADP
hls-12456	118	16	nci	nci	PROPN
hls-12456	118	17	was	be	AUX
hls-12456	118	18	observed	observe	VERB
hls-12456	118	19	,	,	PUNCT
hls-12456	118	20	indicating	indicate	VERB
hls-12456	118	21	a	a	DET
hls-12456	118	22	decrease	decrease	NOUN
hls-12456	118	23	in	in	ADP
hls-12456	118	24	the	the	DET
hls-12456	118	25	level	level	NOUN
hls-12456	118	26	of	of	ADP
hls-12456	118	27	cell	cell	NOUN
hls-12456	118	28	differentiation	differentiation	NOUN
hls-12456	118	29	;	;	PUNCT
hls-12456	118	30	these	these	DET
hls-12456	118	31	data	datum	NOUN
hls-12456	118	32	are	be	AUX
hls-12456	118	33	highlighted	highlight	VERB
hls-12456	118	34	in	in	ADP
hls-12456	118	35	table	table	NOUN
hls-12456	118	36	3	3	NUM
hls-12456	118	37	.	.	PUNCT
hls-12456	119	1	the	the	DET
hls-12456	119	2	described	describe	VERB
hls-12456	119	3	increase	increase	NOUN
hls-12456	119	4	in	in	ADP
hls-12456	119	5	nci	nci	PROPN
hls-12456	119	6	is	be	AUX
hls-12456	119	7	often	often	ADV
hls-12456	119	8	accompanied	accompany	VERB
hls-12456	119	9	by	by	ADP
hls-12456	119	10	a	a	DET
hls-12456	119	11	decrease	decrease	NOUN
hls-12456	119	12	in	in	ADP
hls-12456	119	13	the	the	DET
hls-12456	119	14	concentration	concentration	NOUN
hls-12456	119	15	of	of	ADP
hls-12456	119	16	cytoplasmic	cytoplasmic	ADJ
hls-12456	119	17	rna	rna	NOUN
hls-12456	119	18	in	in	ADP
hls-12456	119	19	metastatic	metastatic	ADJ
hls-12456	119	20	cell	cell	NOUN
hls-12456	119	21	populations	population	NOUN
hls-12456	119	22	,	,	PUNCT
hls-12456	119	23	which	which	PRON
hls-12456	119	24	can	can	AUX
hls-12456	119	25	be	be	AUX
hls-12456	119	26	interpreted	interpret	VERB
hls-12456	119	27	as	as	ADP
hls-12456	119	28	a	a	DET
hls-12456	119	29	sign	sign	NOUN
hls-12456	119	30	of	of	ADP
hls-12456	119	31	suppression	suppression	NOUN
hls-12456	119	32	of	of	ADP
hls-12456	119	33	their	their	PRON
hls-12456	119	34	synthetic	synthetic	ADJ
hls-12456	119	35	activity	activity	NOUN
hls-12456	119	36	.	.	PUNCT
hls-12456	120	1	thus	thus	ADV
hls-12456	120	2	,	,	PUNCT
hls-12456	120	3	this	this	PRON
hls-12456	120	4	can	can	AUX
hls-12456	120	5	also	also	ADV
hls-12456	120	6	be	be	AUX
hls-12456	120	7	considered	consider	VERB
hls-12456	120	8	a	a	DET
hls-12456	120	9	marker	marker	NOUN
hls-12456	120	10	of	of	ADP
hls-12456	120	11	a	a	DET
hls-12456	120	12	decrease	decrease	NOUN
hls-12456	120	13	in	in	ADP
hls-12456	120	14	the	the	DET
hls-12456	120	15	level	level	NOUN
hls-12456	120	16	of	of	ADP
hls-12456	120	17	cell	cell	NOUN
hls-12456	120	18	differentiation	differentiation	NOUN
hls-12456	120	19	in	in	ADP
hls-12456	120	20	metastatic	metastatic	ADJ
hls-12456	120	21	nodes	node	NOUN
hls-12456	120	22	.	.	PUNCT
hls-12456	121	1	in	in	ADP
hls-12456	121	2	general	general	ADJ
hls-12456	121	3	,	,	PUNCT
hls-12456	121	4	the	the	DET
hls-12456	121	5	obtained	obtain	VERB
hls-12456	121	6	data	datum	NOUN
hls-12456	121	7	indicate	indicate	VERB
hls-12456	121	8	the	the	DET
hls-12456	121	9	complexity	complexity	NOUN
hls-12456	121	10	and	and	CCONJ
hls-12456	121	11	multiplicity	multiplicity	NOUN
hls-12456	121	12	of	of	ADP
hls-12456	121	13	pathways	pathway	NOUN
hls-12456	121	14	through	through	ADP
hls-12456	121	15	which	which	PRON
hls-12456	121	16	tumor	tumor	NOUN
hls-12456	121	17	cells	cell	NOUN
hls-12456	121	18	develop	develop	VERB
hls-12456	121	19	and	and	CCONJ
hls-12456	121	20	adapt	adapt	VERB
hls-12456	121	21	in	in	ADP
hls-12456	121	22	both	both	CCONJ
hls-12456	121	23	primary	primary	ADJ
hls-12456	121	24	and	and	CCONJ
hls-12456	121	25	metastatic	metastatic	ADJ
hls-12456	121	26	foci	focus	NOUN
hls-12456	121	27	.	.	PUNCT
hls-12456	122	1	the	the	DET
hls-12456	122	2	large	large	ADJ
hls-12456	122	3	variability	variability	NOUN
hls-12456	122	4	in	in	ADP
hls-12456	122	5	the	the	DET
hls-12456	122	6	molecular	molecular	ADJ
hls-12456	122	7	profile	profile	NOUN
hls-12456	122	8	and	and	CCONJ
hls-12456	122	9	functional	functional	ADJ
hls-12456	122	10	activity	activity	NOUN
hls-12456	122	11	underscores	underscore	VERB
hls-12456	122	12	the	the	DET
hls-12456	122	13	need	need	NOUN
hls-12456	122	14	for	for	ADP
hls-12456	122	15	further	further	ADJ
hls-12456	122	16	detailed	detailed	ADJ
hls-12456	122	17	study	study	NOUN
hls-12456	122	18	of	of	ADP
hls-12456	122	19	the	the	DET
hls-12456	122	20	mechanisms	mechanism	NOUN
hls-12456	122	21	of	of	ADP
hls-12456	122	22	oncogenesis	oncogenesis	NOUN
hls-12456	122	23	and	and	CCONJ
hls-12456	122	24	metastasis	metastasis	NOUN
hls-12456	122	25	at	at	ADP
hls-12456	122	26	the	the	DET
hls-12456	122	27	cellular	cellular	ADJ
hls-12456	122	28	level	level	NOUN
hls-12456	122	29	(	(	PUNCT
hls-12456	122	30	table	table	NOUN
hls-12456	122	31	4	4	NUM
hls-12456	122	32	)	)	PUNCT
hls-12456	122	33	.	.	PUNCT
hls-12456	123	1	according	accord	VERB
hls-12456	123	2	to	to	ADP
hls-12456	123	3	the	the	DET
hls-12456	123	4	obtained	obtain	VERB
hls-12456	123	5	data	datum	NOUN
hls-12456	123	6	,	,	PUNCT
hls-12456	123	7	in	in	ADP
hls-12456	123	8	36.7	36.7	NUM
hls-12456	123	9	%	%	NOUN
hls-12456	123	10	of	of	ADP
hls-12456	123	11	cases	case	NOUN
hls-12456	123	12	where	where	SCONJ
hls-12456	123	13	the	the	DET
hls-12456	123	14	dnaai	dnaai	PROPN
hls-12456	123	15	increases	increase	NOUN
hls-12456	123	16	in	in	ADP
hls-12456	123	17	metastatic	metastatic	ADJ
hls-12456	123	18	cell	cell	NOUN
hls-12456	123	19	populations	population	NOUN
hls-12456	123	20	,	,	PUNCT
hls-12456	123	21	there	there	PRON
hls-12456	123	22	is	be	VERB
hls-12456	123	23	also	also	ADV
hls-12456	123	24	a	a	DET
hls-12456	123	25	significant	significant	ADJ
hls-12456	123	26	decrease	decrease	NOUN
hls-12456	123	27	in	in	ADP
hls-12456	123	28	nuclear	nuclear	ADJ
hls-12456	123	29	rna	rna	NOUN
hls-12456	123	30	levels	level	NOUN
hls-12456	123	31	,	,	PUNCT
hls-12456	123	32	which	which	PRON
hls-12456	123	33	may	may	AUX
hls-12456	123	34	indicate	indicate	VERB
hls-12456	123	35	the	the	DET
hls-12456	123	36	dominance	dominance	NOUN
hls-12456	123	37	of	of	ADP
hls-12456	123	38	dna	dna	PROPN
hls-12456	123	39	synthesis	synthesis	NOUN
hls-12456	123	40	processes	process	NOUN
hls-12456	123	41	in	in	ADP
hls-12456	123	42	the	the	DET
hls-12456	123	43	nucleus	nucleus	NOUN
hls-12456	123	44	.	.	PUNCT
hls-12456	124	1	concurrently	concurrently	ADV
hls-12456	124	2	,	,	PUNCT
hls-12456	124	3	there	there	PRON
hls-12456	124	4	is	be	VERB
hls-12456	124	5	an	an	DET
hls-12456	124	6	increase	increase	NOUN
hls-12456	124	7	in	in	ADP
hls-12456	124	8	cytoplasmic	cytoplasmic	ADJ
hls-12456	124	9	rna	rna	NOUN
hls-12456	124	10	levels	level	NOUN
hls-12456	124	11	(	(	PUNCT
hls-12456	124	12	30	30	NUM
hls-12456	124	13	%	%	NOUN
hls-12456	124	14	)	)	PUNCT
hls-12456	124	15	,	,	PUNCT
hls-12456	124	16	indicating	indicate	VERB
hls-12456	124	17	the	the	DET
hls-12456	124	18	activation	activation	NOUN
hls-12456	124	19	of	of	ADP
hls-12456	124	20	synthetic	synthetic	ADJ
hls-12456	124	21	processes	process	NOUN
hls-12456	124	22	within	within	ADP
hls-12456	124	23	the	the	DET
hls-12456	124	24	cell	cell	NOUN
hls-12456	124	25	.	.	PUNCT
hls-12456	125	1	therefore	therefore	ADV
hls-12456	125	2	,	,	PUNCT
hls-12456	125	3	it	it	PRON
hls-12456	125	4	can	can	AUX
hls-12456	125	5	be	be	AUX
hls-12456	125	6	assumed	assume	VERB
hls-12456	125	7	that	that	SCONJ
hls-12456	125	8	in	in	ADP
hls-12456	125	9	the	the	DET
hls-12456	125	10	investigated	investigate	VERB
hls-12456	125	11	metastatic	metastatic	NOUN
hls-12456	125	12	nodes	node	NOUN
hls-12456	125	13	,	,	PUNCT
hls-12456	125	14	the	the	DET
hls-12456	125	15	process	process	NOUN
hls-12456	125	16	of	of	ADP
hls-12456	125	17	dna	dna	ADJ
hls-12456	125	18	synthesis	synthesis	NOUN
hls-12456	125	19	in	in	ADP
hls-12456	125	20	some	some	DET
hls-12456	125	21	tumor	tumor	NOUN
hls-12456	125	22	cells	cell	NOUN
hls-12456	125	23	occurs	occur	VERB
hls-12456	125	24	through	through	ADP
hls-12456	125	25	endomitosis	endomitosis	NOUN
hls-12456	125	26	,	,	PUNCT
hls-12456	125	27	i.e.	i.e.	X
hls-12456	125	28	,	,	PUNCT
hls-12456	125	29	dna	dna	NOUN
hls-12456	125	30	replication	replication	NOUN
hls-12456	125	31	without	without	ADP
hls-12456	125	32	morphological	morphological	ADJ
hls-12456	125	33	and	and	CCONJ
hls-12456	125	34	functional	functional	ADJ
hls-12456	125	35	changes	change	NOUN
hls-12456	125	36	in	in	ADP
hls-12456	125	37	cells	cell	NOUN
hls-12456	125	38	.	.	PUNCT
hls-12456	126	1	the	the	DET
hls-12456	126	2	lack	lack	NOUN
hls-12456	126	3	of	of	ADP
hls-12456	126	4	a	a	DET
hls-12456	126	5	clear	clear	ADJ
hls-12456	126	6	inverse	inverse	NOUN
hls-12456	126	7	correlation	correlation	NOUN
hls-12456	126	8	between	between	ADP
hls-12456	126	9	dna	dna	PROPN
hls-12456	126	10	and	and	CCONJ
hls-12456	126	11	rna	rna	NOUN
hls-12456	126	12	synthesis	synthesis	NOUN
hls-12456	126	13	can	can	AUX
hls-12456	126	14	be	be	AUX
hls-12456	126	15	explained	explain	VERB
hls-12456	126	16	by	by	ADP
hls-12456	126	17	the	the	DET
hls-12456	126	18	fact	fact	NOUN
hls-12456	126	19	that	that	SCONJ
hls-12456	126	20	in	in	ADP
hls-12456	126	21	healthy	healthy	ADJ
hls-12456	126	22	cells	cell	NOUN
hls-12456	126	23	,	,	PUNCT
hls-12456	126	24	differentiation	differentiation	NOUN
hls-12456	126	25	processes	process	NOUN
hls-12456	126	26	,	,	PUNCT
hls-12456	126	27	and	and	CCONJ
hls-12456	126	28	dna	dna	NOUN
hls-12456	126	29	synthesis	synthesis	NOUN
hls-12456	126	30	activation	activation	NOUN
hls-12456	126	31	are	be	AUX
hls-12456	126	32	typically	typically	ADV
hls-12456	126	33	regulated	regulate	VERB
hls-12456	126	34	by	by	ADP
hls-12456	126	35	different	different	ADJ
hls-12456	126	36	biological	biological	ADJ
hls-12456	126	37	pathways	pathway	NOUN
hls-12456	126	38	and	and	CCONJ
hls-12456	126	39	regulatory	regulatory	ADJ
hls-12456	126	40	mechanisms	mechanism	NOUN
hls-12456	126	41	.	.	PUNCT
hls-12456	127	1	this	this	PRON
hls-12456	127	2	may	may	AUX
hls-12456	127	3	involve	involve	VERB
hls-12456	127	4	the	the	DET
hls-12456	127	5	interaction	interaction	NOUN
hls-12456	127	6	of	of	ADP
hls-12456	127	7	various	various	ADJ
hls-12456	127	8	genetic	genetic	ADJ
hls-12456	127	9	factors	factor	NOUN
hls-12456	127	10	,	,	PUNCT
hls-12456	127	11	signaling	signal	VERB
hls-12456	127	12	pathways	pathway	NOUN
hls-12456	127	13	,	,	PUNCT
hls-12456	127	14	and	and	CCONJ
hls-12456	127	15	molecular	molecular	ADJ
hls-12456	127	16	regulators	regulator	NOUN
hls-12456	127	17	that	that	PRON
hls-12456	127	18	determine	determine	VERB
hls-12456	127	19	when	when	SCONJ
hls-12456	127	20	and	and	CCONJ
hls-12456	127	21	how	how	SCONJ
hls-12456	127	22	a	a	DET
hls-12456	127	23	cell	cell	NOUN
hls-12456	127	24	enters	enter	VERB
hls-12456	127	25	the	the	DET
hls-12456	127	26	process	process	NOUN
hls-12456	127	27	of	of	ADP
hls-12456	127	28	division	division	NOUN
hls-12456	127	29	or	or	CCONJ
hls-12456	127	30	replication	replication	NOUN
hls-12456	127	31	of	of	ADP
hls-12456	127	32	its	its	PRON
hls-12456	127	33	genetic	genetic	ADJ
hls-12456	127	34	material.14,15	material.14,15	NOUN
hls-12456	127	35	a	a	DET
hls-12456	127	36	comparison	comparison	NOUN
hls-12456	127	37	of	of	ADP
hls-12456	127	38	the	the	DET
hls-12456	127	39	nci	nci	PROPN
hls-12456	127	40	and	and	CCONJ
hls-12456	127	41	nuclear	nuclear	ADJ
hls-12456	127	42	rna	rna	NOUN
hls-12456	127	43	concentration	concentration	NOUN
hls-12456	127	44	in	in	ADP
hls-12456	127	45	the	the	DET
hls-12456	127	46	metastatic	metastatic	ADJ
hls-12456	127	47	population	population	NOUN
hls-12456	127	48	of	of	ADP
hls-12456	127	49	tumor	tumor	NOUN
hls-12456	127	50	cells	cell	NOUN
hls-12456	127	51	with	with	ADP
hls-12456	127	52	those	those	PRON
hls-12456	127	53	in	in	ADP
hls-12456	127	54	primary	primary	ADJ
hls-12456	127	55	tumor	tumor	NOUN
hls-12456	127	56	cells	cell	NOUN
hls-12456	127	57	is	be	AUX
hls-12456	127	58	demonstrated	demonstrate	VERB
hls-12456	127	59	in	in	ADP
hls-12456	127	60	table	table	NOUN
hls-12456	127	61	4	4	NUM
hls-12456	127	62	.	.	PUNCT
hls-12456	128	1	it	it	PRON
hls-12456	128	2	is	be	AUX
hls-12456	128	3	also	also	ADV
hls-12456	128	4	worth	worth	ADJ
hls-12456	128	5	noting	note	VERB
hls-12456	128	6	that	that	SCONJ
hls-12456	128	7	an	an	DET
hls-12456	128	8	increase	increase	NOUN
hls-12456	128	9	in	in	ADP
hls-12456	128	10	nci	nci	PROPN
hls-12456	128	11	in	in	ADP
hls-12456	128	12	metastases	metastasis	NOUN
hls-12456	128	13	is	be	AUX
hls-12456	128	14	usually	usually	ADV
hls-12456	128	15	accompanied	accompany	VERB
hls-12456	128	16	by	by	ADP
hls-12456	128	17	a	a	DET
hls-12456	128	18	decrease	decrease	NOUN
hls-12456	128	19	in	in	ADP
hls-12456	128	20	nuclear	nuclear	ADJ
hls-12456	128	21	rna	rna	NOUN
hls-12456	128	22	concentration	concentration	NOUN
hls-12456	128	23	.	.	PUNCT
hls-12456	129	1	this	this	PRON
hls-12456	129	2	may	may	AUX
hls-12456	129	3	indicate	indicate	VERB
hls-12456	129	4	the	the	DET
hls-12456	129	5	complex	complex	ADJ
hls-12456	129	6	nature	nature	NOUN
hls-12456	129	7	of	of	ADP
hls-12456	129	8	metastatic	metastatic	ADJ
hls-12456	129	9	processes	process	NOUN
hls-12456	129	10	,	,	PUNCT
hls-12456	129	11	where	where	SCONJ
hls-12456	129	12	changes	change	NOUN
hls-12456	129	13	in	in	ADP
hls-12456	129	14	one	one	NUM
hls-12456	129	15	aspect	aspect	NOUN
hls-12456	129	16	of	of	ADP
hls-12456	129	17	cell	cell	NOUN
hls-12456	129	18	function	function	NOUN
hls-12456	129	19	do	do	AUX
hls-12456	129	20	not	not	PART
hls-12456	129	21	necessarily	necessarily	ADV
hls-12456	129	22	reflect	reflect	VERB
hls-12456	129	23	or	or	CCONJ
hls-12456	129	24	impact	impact	VERB
hls-12456	129	25	other	other	ADJ
hls-12456	129	26	processes	process	NOUN
hls-12456	129	27	to	to	ADP
hls-12456	129	28	the	the	DET
hls-12456	129	29	same	same	ADJ
hls-12456	129	30	extent	extent	NOUN
hls-12456	129	31	.	.	PUNCT
hls-12456	130	1	thus	thus	ADV
hls-12456	130	2	,	,	PUNCT
hls-12456	130	3	this	this	DET
hls-12456	130	4	section	section	NOUN
hls-12456	130	5	has	have	AUX
hls-12456	130	6	highlighted	highlight	VERB
hls-12456	130	7	the	the	DET
hls-12456	130	8	results	result	NOUN
hls-12456	130	9	of	of	ADP
hls-12456	130	10	a	a	DET
hls-12456	130	11	significant	significant	ADJ
hls-12456	130	12	number	number	NOUN
hls-12456	130	13	of	of	ADP
hls-12456	130	14	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	130	15	studies	study	NOUN
hls-12456	130	16	on	on	ADP
hls-12456	130	17	the	the	DET
hls-12456	130	18	levels	level	NOUN
hls-12456	130	19	of	of	ADP
hls-12456	130	20	dna	dna	PROPN
hls-12456	130	21	and	and	CCONJ
hls-12456	130	22	rna	rna	NOUN
hls-12456	130	23	in	in	ADP
hls-12456	130	24	both	both	CCONJ
hls-12456	130	25	primary	primary	ADJ
hls-12456	130	26	and	and	CCONJ
hls-12456	130	27	metastatic	metastatic	ADJ
hls-12456	130	28	tumors	tumor	NOUN
hls-12456	130	29	.	.	PUNCT
hls-12456	131	1	several	several	ADJ
hls-12456	131	2	important	important	ADJ
hls-12456	131	3	aspects	aspect	NOUN
hls-12456	131	4	related	relate	VERB
hls-12456	131	5	to	to	ADP
hls-12456	131	6	the	the	DET
hls-12456	131	7	content	content	NOUN
hls-12456	131	8	of	of	ADP
hls-12456	131	9	nucleic	nucleic	ADJ
hls-12456	131	10	acids	acid	NOUN
hls-12456	131	11	in	in	ADP
hls-12456	131	12	these	these	DET
hls-12456	131	13	cell	cell	NOUN
hls-12456	131	14	populations	population	NOUN
hls-12456	131	15	have	have	AUX
hls-12456	131	16	been	be	AUX
hls-12456	131	17	discussed	discuss	VERB
hls-12456	131	18	.	.	PUNCT
hls-12456	132	1	it	it	PRON
hls-12456	132	2	has	have	AUX
hls-12456	132	3	been	be	AUX
hls-12456	132	4	found	find	VERB
hls-12456	132	5	that	that	SCONJ
hls-12456	132	6	changes	change	NOUN
hls-12456	132	7	in	in	ADP
hls-12456	132	8	dna	dna	PROPN
hls-12456	132	9	and	and	CCONJ
hls-12456	132	10	rna	rna	NOUN
hls-12456	132	11	concentrations	concentration	NOUN
hls-12456	132	12	occur	occur	VERB
hls-12456	132	13	in	in	ADP
hls-12456	132	14	metastases	metastasis	NOUN
hls-12456	132	15	,	,	PUNCT
hls-12456	132	16	and	and	CCONJ
hls-12456	132	17	these	these	DET
hls-12456	132	18	changes	change	NOUN
hls-12456	132	19	do	do	AUX
hls-12456	132	20	not	not	PART
hls-12456	132	21	always	always	ADV
hls-12456	132	22	correlate	correlate	VERB
hls-12456	132	23	with	with	ADP
hls-12456	132	24	each	each	DET
hls-12456	132	25	other	other	ADJ
hls-12456	132	26	.	.	PUNCT
hls-12456	133	1	this	this	PRON
hls-12456	133	2	indicates	indicate	VERB
hls-12456	133	3	the	the	DET
hls-12456	133	4	presence	presence	NOUN
hls-12456	133	5	of	of	ADP
hls-12456	133	6	distinct	distinct	ADJ
hls-12456	133	7	polymorphisms	polymorphism	NOUN
hls-12456	133	8	and	and	CCONJ
hls-12456	133	9	functional	functional	ADJ
hls-12456	133	10	heterogeneity	heterogeneity	NOUN
hls-12456	133	11	in	in	ADP
hls-12456	133	12	populations	population	NOUN
hls-12456	133	13	of	of	ADP
hls-12456	133	14	tumor	tumor	NOUN
hls-12456	133	15	cells.16	cells.16	NOUN
hls-12456	133	16	changes	change	NOUN
hls-12456	133	17	in	in	ADP
hls-12456	133	18	the	the	DET
hls-12456	133	19	concentration	concentration	NOUN
hls-12456	133	20	of	of	ADP
hls-12456	133	21	nuclear	nuclear	ADJ
hls-12456	133	22	and	and	CCONJ
hls-12456	133	23	cytoplasmic	cytoplasmic	ADJ
hls-12456	133	24	rna	rna	NOUN
hls-12456	133	25	are	be	AUX
hls-12456	133	26	particularly	particularly	ADV
hls-12456	133	27	important	important	ADJ
hls-12456	133	28	,	,	PUNCT
hls-12456	133	29	as	as	SCONJ
hls-12456	133	30	they	they	PRON
hls-12456	133	31	may	may	AUX
hls-12456	133	32	serve	serve	VERB
hls-12456	133	33	as	as	ADP
hls-12456	133	34	indicators	indicator	NOUN
hls-12456	133	35	of	of	ADP
hls-12456	133	36	metabolic	metabolic	NOUN
hls-12456	133	37	and	and	CCONJ
hls-12456	133	38	synthetic	synthetic	ADJ
hls-12456	133	39	processes	process	NOUN
hls-12456	133	40	.	.	PUNCT
hls-12456	134	1	there	there	PRON
hls-12456	134	2	is	be	VERB
hls-12456	134	3	a	a	DET
hls-12456	134	4	tendency	tendency	NOUN
hls-12456	134	5	to	to	PART
hls-12456	134	6	decrease	decrease	VERB
hls-12456	134	7	nuclear	nuclear	ADJ
hls-12456	134	8	rna	rna	NOUN
hls-12456	134	9	concentration	concentration	NOUN
hls-12456	134	10	and	and	CCONJ
hls-12456	134	11	increase	increase	VERB
hls-12456	134	12	cytoplasmic	cytoplasmic	ADJ
hls-12456	134	13	rna	rna	NOUN
hls-12456	134	14	concentration	concentration	NOUN
hls-12456	134	15	in	in	ADP
hls-12456	134	16	metastases	metastasis	NOUN
hls-12456	134	17	,	,	PUNCT
hls-12456	134	18	indicating	indicate	VERB
hls-12456	134	19	the	the	DET
hls-12456	134	20	activation	activation	NOUN
hls-12456	134	21	of	of	ADP
hls-12456	134	22	synthetic	synthetic	ADJ
hls-12456	134	23	processes	process	NOUN
hls-12456	134	24	in	in	ADP
hls-12456	134	25	cells	cell	NOUN
hls-12456	134	26	and	and	CCONJ
hls-12456	134	27	a	a	DET
hls-12456	134	28	decrease	decrease	NOUN
hls-12456	134	29	in	in	ADP
hls-12456	134	30	their	their	PRON
hls-12456	134	31	degree	degree	NOUN
hls-12456	134	32	of	of	ADP
hls-12456	134	33	differentiation	differentiation	NOUN
hls-12456	134	34	.	.	PUNCT
hls-12456	135	1	it	it	PRON
hls-12456	135	2	has	have	AUX
hls-12456	135	3	also	also	ADV
hls-12456	135	4	been	be	AUX
hls-12456	135	5	observed	observe	VERB
hls-12456	135	6	that	that	SCONJ
hls-12456	135	7	alterations	alteration	NOUN
hls-12456	135	8	in	in	ADP
hls-12456	135	9	dna	dna	PROPN
hls-12456	135	10	and	and	CCONJ
hls-12456	135	11	rna	rna	NOUN
hls-12456	135	12	levels	level	NOUN
hls-12456	135	13	in	in	ADP
hls-12456	135	14	metastases	metastasis	NOUN
hls-12456	135	15	do	do	AUX
hls-12456	135	16	not	not	PART
hls-12456	135	17	always	always	ADV
hls-12456	135	18	reflect	reflect	VERB
hls-12456	135	19	similar	similar	ADJ
hls-12456	135	20	changes	change	NOUN
hls-12456	135	21	in	in	ADP
hls-12456	135	22	the	the	DET
hls-12456	135	23	primary	primary	ADJ
hls-12456	135	24	tumor	tumor	NOUN
hls-12456	135	25	.	.	PUNCT
hls-12456	136	1	it	it	PRON
hls-12456	136	2	is	be	AUX
hls-12456	136	3	established	establish	VERB
hls-12456	136	4	that	that	SCONJ
hls-12456	136	5	dna	dna	PROPN
hls-12456	136	6	and	and	CCONJ
hls-12456	136	7	rna	rna	NOUN
hls-12456	136	8	synthesis	synthesis	NOUN
hls-12456	136	9	processes	process	NOUN
hls-12456	136	10	in	in	ADP
hls-12456	136	11	tumor	tumor	NOUN
hls-12456	136	12	cells	cell	NOUN
hls-12456	136	13	may	may	AUX
hls-12456	136	14	occur	occur	VERB
hls-12456	136	15	independently	independently	ADV
hls-12456	136	16	of	of	ADP
hls-12456	136	17	each	each	DET
hls-12456	136	18	other	other	ADJ
hls-12456	136	19	,	,	PUNCT
hls-12456	136	20	indicating	indicate	VERB
hls-12456	136	21	the	the	DET
hls-12456	136	22	presence	presence	NOUN
hls-12456	136	23	of	of	ADP
hls-12456	136	24	different	different	ADJ
hls-12456	136	25	regulatory	regulatory	ADJ
hls-12456	136	26	mechanisms	mechanism	NOUN
hls-12456	136	27	.	.	PUNCT
hls-12456	137	1	these	these	DET
hls-12456	137	2	findings	finding	NOUN
hls-12456	137	3	underscore	underscore	VERB
hls-12456	137	4	the	the	DET
hls-12456	137	5	complexity	complexity	NOUN
hls-12456	137	6	of	of	ADP
hls-12456	137	7	the	the	DET
hls-12456	137	8	molecular	molecular	ADJ
hls-12456	137	9	mechanisms	mechanism	NOUN
hls-12456	137	10	underlying	underlie	VERB
hls-12456	137	11	the	the	DET
hls-12456	137	12	development	development	NOUN
hls-12456	137	13	and	and	CCONJ
hls-12456	137	14	progression	progression	NOUN
hls-12456	137	15	of	of	ADP
hls-12456	137	16	cancer	cancer	NOUN
hls-12456	137	17	,	,	PUNCT
hls-12456	137	18	especially	especially	ADV
hls-12456	137	19	in	in	ADP
hls-12456	137	20	the	the	DET
hls-12456	137	21	context	context	NOUN
hls-12456	137	22	of	of	ADP
hls-12456	137	23	metastasis	metastasis	NOUN
hls-12456	137	24	.	.	PUNCT
hls-12456	138	1	discussion	discussion	VERB
hls-12456	138	2	the	the	DET
hls-12456	138	3	analysis	analysis	NOUN
hls-12456	138	4	and	and	CCONJ
hls-12456	138	5	interpretation	interpretation	NOUN
hls-12456	138	6	of	of	ADP
hls-12456	138	7	the	the	DET
hls-12456	138	8	obtained	obtain	VERB
hls-12456	138	9	data	datum	NOUN
hls-12456	138	10	have	have	AUX
hls-12456	138	11	demonstrated	demonstrate	VERB
hls-12456	138	12	significant	significant	ADJ
hls-12456	138	13	diversity	diversity	NOUN
hls-12456	138	14	in	in	ADP
hls-12456	138	15	dna	dna	PROPN
hls-12456	138	16	and	and	CCONJ
hls-12456	138	17	rna	rna	NOUN
hls-12456	138	18	concentrations	concentration	NOUN
hls-12456	138	19	in	in	ADP
hls-12456	138	20	primary	primary	ADJ
hls-12456	138	21	and	and	CCONJ
hls-12456	138	22	metastatic	metastatic	ADJ
hls-12456	138	23	populations	population	NOUN
hls-12456	138	24	of	of	ADP
hls-12456	138	25	tumor	tumor	NOUN
hls-12456	138	26	cells	cell	NOUN
hls-12456	138	27	,	,	PUNCT
hls-12456	138	28	requiring	require	VERB
hls-12456	138	29	further	further	ADJ
hls-12456	138	30	clarification	clarification	NOUN
hls-12456	138	31	regarding	regard	VERB
hls-12456	138	32	the	the	DET
hls-12456	138	33	mechanisms	mechanism	NOUN
hls-12456	138	34	regulating	regulate	VERB
hls-12456	138	35	the	the	DET
hls-12456	138	36	synthesis	synthesis	NOUN
hls-12456	138	37	of	of	ADP
hls-12456	138	38	these	these	DET
hls-12456	138	39	critically	critically	ADV
hls-12456	138	40	important	important	ADJ
hls-12456	138	41	molecular	molecular	ADJ
hls-12456	138	42	compounds	compound	NOUN
hls-12456	138	43	.	.	PUNCT
hls-12456	139	1	in	in	ADP
hls-12456	139	2	this	this	DET
hls-12456	139	3	context	context	NOUN
hls-12456	139	4	,	,	PUNCT
hls-12456	139	5	particular	particular	ADJ
hls-12456	139	6	attention	attention	NOUN
hls-12456	139	7	is	be	AUX
hls-12456	139	8	deserved	deserve	VERB
hls-12456	139	9	for	for	ADP
hls-12456	139	10	understanding	understand	VERB
hls-12456	139	11	the	the	DET
hls-12456	139	12	role	role	NOUN
hls-12456	139	13	played	play	VERB
hls-12456	139	14	by	by	ADP
hls-12456	139	15	various	various	ADJ
hls-12456	139	16	types	type	NOUN
hls-12456	139	17	of	of	ADP
hls-12456	139	18	nucleic	nucleic	ADJ
hls-12456	139	19	acids	acid	NOUN
hls-12456	139	20	,	,	PUNCT
hls-12456	139	21	including	include	VERB
hls-12456	139	22	noncoding	noncode	VERB
hls-12456	139	23	rnas	rna	NOUN
hls-12456	139	24	(	(	PUNCT
hls-12456	139	25	ncrnas	ncrnas	PROPN
hls-12456	139	26	)	)	PUNCT
hls-12456	139	27	,	,	PUNCT
hls-12456	139	28	in	in	ADP
hls-12456	139	29	the	the	DET
hls-12456	139	30	development	development	NOUN
hls-12456	139	31	and	and	CCONJ
hls-12456	139	32	progression	progression	NOUN
hls-12456	139	33	of	of	ADP
hls-12456	139	34	oncological	oncological	ADJ
hls-12456	139	35	diseases	disease	NOUN
hls-12456	139	36	.	.	PUNCT
hls-12456	140	1	investigating	investigate	VERB
hls-12456	140	2	the	the	DET
hls-12456	140	3	mechanisms	mechanism	NOUN
hls-12456	140	4	through	through	ADP
hls-12456	140	5	which	which	PRON
hls-12456	140	6	nucleic	nucleic	ADJ
hls-12456	140	7	acids	acid	NOUN
hls-12456	140	8	influence	influence	NOUN
hls-12456	140	9	tumor	tumor	NOUN
hls-12456	140	10	growth	growth	NOUN
hls-12456	140	11	and	and	CCONJ
hls-12456	140	12	metastasis	metastasis	NOUN
hls-12456	140	13	may	may	AUX
hls-12456	140	14	shed	shed	VERB
hls-12456	140	15	social	social	ADJ
hls-12456	140	16	and	and	CCONJ
hls-12456	140	17	political	political	ADJ
hls-12456	140	18	factors	factor	NOUN
hls-12456	140	19	affecting	affect	VERB
hls-12456	140	20	public	public	ADJ
hls-12456	140	21	health	health	NOUN
hls-12456	140	22	table	table	NOUN
hls-12456	140	23	4	4	NUM
hls-12456	140	24	.	.	PUNCT
hls-12456	141	1	the	the	DET
hls-12456	141	2	amount	amount	NOUN
hls-12456	141	3	of	of	ADP
hls-12456	141	4	rna	rna	NOUN
hls-12456	141	5	in	in	ADP
hls-12456	141	6	the	the	DET
hls-12456	141	7	nuclei	nucleus	NOUN
hls-12456	141	8	of	of	ADP
hls-12456	141	9	tumor	tumor	NOUN
hls-12456	141	10	cells	cell	NOUN
hls-12456	141	11	of	of	ADP
hls-12456	141	12	metastases	metastasis	NOUN
hls-12456	141	13	in	in	ADP
hls-12456	141	14	comparison	comparison	NOUN
hls-12456	141	15	with	with	ADP
hls-12456	141	16	the	the	DET
hls-12456	141	17	primary	primary	ADJ
hls-12456	141	18	tumor	tumor	NOUN
hls-12456	141	19	,	,	PUNCT
hls-12456	141	20	depending	depend	VERB
hls-12456	141	21	on	on	ADP
hls-12456	141	22	the	the	DET
hls-12456	141	23	nuclearcytoplasmic	nuclearcytoplasmic	ADJ
hls-12456	141	24	index	index	NOUN
hls-12456	141	25	(	(	PUNCT
hls-12456	141	26	nci	nci	PROPN
hls-12456	141	27	)	)	PUNCT
hls-12456	141	28	(	(	PUNCT
hls-12456	141	29	abs/%	abs/%	NOUN
hls-12456	141	30	)	)	PUNCT
hls-12456	141	31	.	.	PUNCT
hls-12456	142	1	relative	relative	ADJ
hls-12456	142	2	quantity	quantity	NOUN
hls-12456	142	3	the	the	DET
hls-12456	142	4	value	value	NOUN
hls-12456	142	5	of	of	ADP
hls-12456	142	6	nci	nci	PROPN
hls-12456	142	7	in	in	ADP
hls-12456	142	8	metastasis	metastasis	NOUN
hls-12456	142	9	in	in	ADP
hls-12456	142	10	comparison	comparison	NOUN
hls-12456	142	11	with	with	ADP
hls-12456	142	12	the	the	DET
hls-12456	142	13	primary	primary	ADJ
hls-12456	142	14	tumor	tumor	NOUN
hls-12456	142	15	in	in	ADP
hls-12456	142	16	total	total	ADJ
hls-12456	142	17	bigger	big	ADJ
hls-12456	142	18	smaller	small	ADJ
hls-12456	142	19	equal	equal	ADJ
hls-12456	142	20	bigger	big	ADJ
hls-12456	142	21	4/13.3	4/13.3	NUM
hls-12456	142	22	6/20	6/20	NUM
hls-12456	142	23	0/0	0/0	NUM
hls-12456	142	24	10/33.3	10/33.3	NUM
hls-12456	142	25	smaller	small	ADJ
hls-12456	142	26	11/36.7	11/36.7	NUM
hls-12456	143	1	5/16.7	5/16.7	NUM
hls-12456	143	2	1/3.3	1/3.3	NUM
hls-12456	143	3	17/56.7	17/56.7	NUM
hls-12456	143	4	equal	equal	ADJ
hls-12456	143	5	2/6.7	2/6.7	NUM
hls-12456	143	6	1/3.3	1/3.3	NUM
hls-12456	143	7	0/0	0/0	NUM
hls-12456	143	8	3/10	3/10	NUM
hls-12456	143	9	in	in	ADP
hls-12456	143	10	total	total	ADJ
hls-12456	143	11	17/56.7	17/56.7	NUM
hls-12456	143	12	12/40	12/40	NUM
hls-12456	143	13	1/3.3	1/3.3	NUM
hls-12456	143	14	30/100	30/100	NUM
hls-12456	143	15	source	source	NOUN
hls-12456	143	16	:	:	PUNCT
hls-12456	143	17	created	create	VERB
hls-12456	143	18	by	by	ADP
hls-12456	143	19	the	the	DET
hls-12456	143	20	authors	author	NOUN
hls-12456	143	21	.	.	PUNCT
hls-12456	144	1	[	[	X
hls-12456	144	2	healthcare	healthcare	NOUN
hls-12456	144	3	in	in	ADP
hls-12456	144	4	low	low	ADJ
hls-12456	144	5	-	-	PUNCT
hls-12456	144	6	resource	resource	NOUN
hls-12456	144	7	settings	setting	NOUN
hls-12456	144	8	2024;12(s2):12456	2024;12(s2):12456	NUM
hls-12456	144	9	]	]	PUNCT
hls-12456	145	1	[	[	X
hls-12456	145	2	page	page	NOUN
hls-12456	145	3	79	79	NUM
hls-12456	145	4	]	]	PUNCT
hls-12456	145	5	table	table	NOUN
hls-12456	145	6	3	3	NUM
hls-12456	145	7	.	.	PUNCT
hls-12456	146	1	the	the	DET
hls-12456	146	2	amount	amount	NOUN
hls-12456	146	3	of	of	ADP
hls-12456	146	4	rna	rna	NOUN
hls-12456	146	5	in	in	ADP
hls-12456	146	6	the	the	DET
hls-12456	146	7	cytoplasm	cytoplasm	NOUN
hls-12456	146	8	of	of	ADP
hls-12456	146	9	tumor	tumor	NOUN
hls-12456	146	10	cells	cell	NOUN
hls-12456	146	11	of	of	ADP
hls-12456	146	12	metastases	metastasis	NOUN
hls-12456	146	13	compared	compare	VERB
hls-12456	146	14	to	to	ADP
hls-12456	146	15	the	the	DET
hls-12456	146	16	primary	primary	ADJ
hls-12456	146	17	tumor	tumor	NOUN
hls-12456	146	18	,	,	PUNCT
hls-12456	146	19	depending	depend	VERB
hls-12456	146	20	on	on	ADP
hls-12456	146	21	the	the	DET
hls-12456	146	22	nuclearcytoplasmic	nuclearcytoplasmic	ADJ
hls-12456	146	23	index	index	NOUN
hls-12456	146	24	(	(	PUNCT
hls-12456	146	25	nci	nci	PROPN
hls-12456	146	26	)	)	PUNCT
hls-12456	146	27	(	(	PUNCT
hls-12456	146	28	abs/%	abs/%	NOUN
hls-12456	146	29	)	)	PUNCT
hls-12456	146	30	.	.	PUNCT
hls-12456	147	1	relative	relative	ADJ
hls-12456	147	2	quantity	quantity	NOUN
hls-12456	147	3	the	the	DET
hls-12456	147	4	value	value	NOUN
hls-12456	147	5	of	of	ADP
hls-12456	147	6	nci	nci	PROPN
hls-12456	147	7	in	in	ADP
hls-12456	147	8	metastasis	metastasis	NOUN
hls-12456	147	9	in	in	ADP
hls-12456	147	10	comparison	comparison	NOUN
hls-12456	147	11	with	with	ADP
hls-12456	147	12	the	the	DET
hls-12456	147	13	primary	primary	ADJ
hls-12456	147	14	tumor	tumor	NOUN
hls-12456	147	15	in	in	ADP
hls-12456	147	16	total	total	ADJ
hls-12456	147	17	bigger	big	ADJ
hls-12456	147	18	smaller	small	ADJ
hls-12456	147	19	equal	equal	ADJ
hls-12456	147	20	bigger	big	ADJ
hls-12456	147	21	0/0	0/0	NUM
hls-12456	148	1	7/23.4	7/23.4	NOUN
hls-12456	148	2	1/3.3	1/3.3	NUM
hls-12456	148	3	8/26.7	8/26.7	NUM
hls-12456	148	4	smaller	small	ADJ
hls-12456	148	5	14/46.7	14/46.7	NUM
hls-12456	148	6	6/20	6/20	NUM
hls-12456	148	7	1/3.3	1/3.3	NUM
hls-12456	148	8	21/70	21/70	NUM
hls-12456	148	9	equal	equal	ADJ
hls-12456	148	10	0/0	0/0	NUM
hls-12456	148	11	0/0	0/0	NOUN
hls-12456	148	12	1/3.3	1/3.3	NUM
hls-12456	148	13	1/3.3	1/3.3	NUM
hls-12456	148	14	in	in	ADP
hls-12456	148	15	total	total	NOUN
hls-12456	148	16	14/46.7	14/46.7	NUM
hls-12456	148	17	13/43.4	13/43.4	NUM
hls-12456	148	18	3/9.9	3/9.9	NUM
hls-12456	148	19	30/100	30/100	NUM
hls-12456	148	20	source	source	NOUN
hls-12456	148	21	:	:	PUNCT
hls-12456	148	22	created	create	VERB
hls-12456	148	23	by	by	ADP
hls-12456	148	24	the	the	DET
hls-12456	148	25	authors	author	NOUN
hls-12456	148	26	.	.	PUNCT
hls-12456	149	1	non	non	ADJ
hls-12456	150	1	-co	-co	PROPN
hls-12456	150	2	mmerc	mmerc	PROPN
hls-12456	150	3	ial	ial	PROPN
hls-12456	150	4	us	us	PROPN
hls-12456	150	5	e	e	NOUN
hls-12456	150	6	o	o	NOUN
hls-12456	150	7	nly	nly	ADV
hls-12456	150	8	light	light	ADJ
hls-12456	150	9	on	on	ADP
hls-12456	150	10	the	the	DET
hls-12456	150	11	complexity	complexity	NOUN
hls-12456	150	12	of	of	ADP
hls-12456	150	13	oncogenesis	oncogenesis	NOUN
hls-12456	150	14	and	and	CCONJ
hls-12456	150	15	outline	outline	VERB
hls-12456	150	16	new	new	ADJ
hls-12456	150	17	perspectives	perspective	NOUN
hls-12456	150	18	for	for	ADP
hls-12456	150	19	developing	develop	VERB
hls-12456	150	20	more	more	ADV
hls-12456	150	21	effective	effective	ADJ
hls-12456	150	22	approaches	approach	NOUN
hls-12456	150	23	to	to	ADP
hls-12456	150	24	oncodiagnosis	oncodiagnosis	NOUN
hls-12456	150	25	and	and	CCONJ
hls-12456	150	26	treatment	treatment	NOUN
hls-12456	150	27	.	.	PUNCT
hls-12456	151	1	in	in	ADP
hls-12456	151	2	their	their	PRON
hls-12456	151	3	study	study	NOUN
hls-12456	151	4	,	,	PUNCT
hls-12456	151	5	feunteun	feunteun	ADJ
hls-12456	151	6	et	et	NOUN
hls-12456	151	7	al.17	al.17	PROPN
hls-12456	151	8	devoted	devote	VERB
hls-12456	151	9	considerable	considerable	ADJ
hls-12456	151	10	attention	attention	NOUN
hls-12456	151	11	to	to	ADP
hls-12456	151	12	the	the	DET
hls-12456	151	13	role	role	NOUN
hls-12456	151	14	of	of	ADP
hls-12456	151	15	non	non	ADJ
hls-12456	151	16	-	-	ADJ
hls-12456	151	17	cell	cell	ADJ
hls-12456	151	18	autonomous	autonomous	ADJ
hls-12456	151	19	effectors	effector	NOUN
hls-12456	151	20	in	in	ADP
hls-12456	151	21	oncogenesis	oncogenesis	NOUN
hls-12456	151	22	and	and	CCONJ
hls-12456	151	23	metastasis	metastasis	NOUN
hls-12456	151	24	.	.	PUNCT
hls-12456	152	1	the	the	DET
hls-12456	152	2	authors	author	NOUN
hls-12456	152	3	examined	examine	VERB
hls-12456	152	4	various	various	ADJ
hls-12456	152	5	factors	factor	NOUN
hls-12456	152	6	and	and	CCONJ
hls-12456	152	7	mechanisms	mechanism	NOUN
hls-12456	152	8	that	that	PRON
hls-12456	152	9	impact	impact	VERB
hls-12456	152	10	the	the	DET
hls-12456	152	11	development	development	NOUN
hls-12456	152	12	and	and	CCONJ
hls-12456	152	13	progression	progression	NOUN
hls-12456	152	14	of	of	ADP
hls-12456	152	15	cancer	cancer	NOUN
hls-12456	152	16	,	,	PUNCT
hls-12456	152	17	but	but	CCONJ
hls-12456	152	18	do	do	AUX
hls-12456	152	19	not	not	PART
hls-12456	152	20	directly	directly	ADV
hls-12456	152	21	originate	originate	VERB
hls-12456	152	22	from	from	ADP
hls-12456	152	23	tumor	tumor	NOUN
hls-12456	152	24	cells	cell	NOUN
hls-12456	152	25	.	.	PUNCT
hls-12456	153	1	these	these	DET
hls-12456	153	2	factors	factor	NOUN
hls-12456	153	3	and	and	CCONJ
hls-12456	153	4	mechanisms	mechanism	NOUN
hls-12456	153	5	interact	interact	VERB
hls-12456	153	6	with	with	ADP
hls-12456	153	7	malignant	malignant	ADJ
hls-12456	153	8	cells	cell	NOUN
hls-12456	153	9	,	,	PUNCT
hls-12456	153	10	originating	originate	VERB
hls-12456	153	11	from	from	ADP
hls-12456	153	12	the	the	DET
hls-12456	153	13	surrounding	surround	VERB
hls-12456	153	14	cellular	cellular	ADJ
hls-12456	153	15	environment	environment	NOUN
hls-12456	153	16	.	.	PUNCT
hls-12456	154	1	thus	thus	ADV
hls-12456	154	2	,	,	PUNCT
hls-12456	154	3	the	the	DET
hls-12456	154	4	tumor	tumor	NOUN
hls-12456	154	5	microenvironment	microenvironment	NOUN
hls-12456	154	6	includes	include	VERB
hls-12456	154	7	various	various	ADJ
hls-12456	154	8	types	type	NOUN
hls-12456	154	9	of	of	ADP
hls-12456	154	10	cells	cell	NOUN
hls-12456	154	11	:	:	PUNCT
hls-12456	154	12	immune	immune	ADJ
hls-12456	154	13	cells	cell	NOUN
hls-12456	154	14	,	,	PUNCT
hls-12456	154	15	fibroblasts	fibroblast	NOUN
hls-12456	154	16	,	,	PUNCT
hls-12456	154	17	endothelial	endothelial	ADJ
hls-12456	154	18	cells	cell	NOUN
hls-12456	154	19	,	,	PUNCT
hls-12456	154	20	extracellular	extracellular	ADJ
hls-12456	154	21	matrix	matrix	NOUN
hls-12456	154	22	,	,	PUNCT
hls-12456	154	23	and	and	CCONJ
hls-12456	154	24	molecules	molecule	NOUN
hls-12456	154	25	secreted	secrete	VERB
hls-12456	154	26	by	by	ADP
hls-12456	154	27	these	these	DET
hls-12456	154	28	cells	cell	NOUN
hls-12456	154	29	.	.	PUNCT
hls-12456	155	1	the	the	DET
hls-12456	155	2	microenvironment	microenvironment	NOUN
hls-12456	155	3	significantly	significantly	ADV
hls-12456	155	4	influences	influence	VERB
hls-12456	155	5	the	the	DET
hls-12456	155	6	growth	growth	NOUN
hls-12456	155	7	,	,	PUNCT
hls-12456	155	8	survival	survival	NOUN
hls-12456	155	9	,	,	PUNCT
hls-12456	155	10	and	and	CCONJ
hls-12456	155	11	metastasis	metastasis	NOUN
hls-12456	155	12	of	of	ADP
hls-12456	155	13	tumor	tumor	NOUN
hls-12456	155	14	cell	cell	NOUN
hls-12456	155	15	populations	population	NOUN
hls-12456	155	16	.	.	PUNCT
hls-12456	156	1	immune	immune	ADJ
hls-12456	156	2	cells	cell	NOUN
hls-12456	156	3	in	in	ADP
hls-12456	156	4	the	the	DET
hls-12456	156	5	tumor	tumor	NOUN
hls-12456	156	6	microenvironment	microenvironment	NOUN
hls-12456	156	7	can	can	AUX
hls-12456	156	8	either	either	CCONJ
hls-12456	156	9	inhibit	inhibit	VERB
hls-12456	156	10	or	or	CCONJ
hls-12456	156	11	promote	promote	VERB
hls-12456	156	12	the	the	DET
hls-12456	156	13	growth	growth	NOUN
hls-12456	156	14	and	and	CCONJ
hls-12456	156	15	spread	spread	VERB
hls-12456	156	16	of	of	ADP
hls-12456	156	17	tumor	tumor	NOUN
hls-12456	156	18	cells	cell	NOUN
hls-12456	156	19	.	.	PUNCT
hls-12456	157	1	for	for	ADP
hls-12456	157	2	example	example	NOUN
hls-12456	157	3	,	,	PUNCT
hls-12456	157	4	some	some	DET
hls-12456	157	5	types	type	NOUN
hls-12456	157	6	of	of	ADP
hls-12456	157	7	immune	immune	ADJ
hls-12456	157	8	cells	cell	NOUN
hls-12456	157	9	may	may	AUX
hls-12456	157	10	secrete	secrete	VERB
hls-12456	157	11	cytokines	cytokine	NOUN
hls-12456	157	12	that	that	PRON
hls-12456	157	13	support	support	VERB
hls-12456	157	14	the	the	DET
hls-12456	157	15	tumor	tumor	NOUN
hls-12456	157	16	,	,	PUNCT
hls-12456	157	17	while	while	SCONJ
hls-12456	157	18	others	other	NOUN
hls-12456	157	19	may	may	AUX
hls-12456	157	20	attack	attack	VERB
hls-12456	157	21	and	and	CCONJ
hls-12456	157	22	destroy	destroy	VERB
hls-12456	157	23	malignant	malignant	ADJ
hls-12456	157	24	cells	cell	NOUN
hls-12456	157	25	.	.	PUNCT
hls-12456	158	1	signaling	signal	VERB
hls-12456	158	2	molecules	molecule	NOUN
hls-12456	158	3	released	release	VERB
hls-12456	158	4	by	by	ADP
hls-12456	158	5	micro	micro	ADJ
hls-12456	158	6	-	-	ADJ
hls-12456	158	7	environmental	environmental	ADJ
hls-12456	158	8	cells	cell	NOUN
hls-12456	158	9	can	can	AUX
hls-12456	158	10	activate	activate	VERB
hls-12456	158	11	or	or	CCONJ
hls-12456	158	12	suppress	suppress	VERB
hls-12456	158	13	specific	specific	ADJ
hls-12456	158	14	signaling	signal	VERB
hls-12456	158	15	pathways	pathway	NOUN
hls-12456	158	16	in	in	ADP
hls-12456	158	17	tumor	tumor	NOUN
hls-12456	158	18	cell	cell	NOUN
hls-12456	158	19	populations	population	NOUN
hls-12456	158	20	,	,	PUNCT
hls-12456	158	21	affecting	affect	VERB
hls-12456	158	22	their	their	PRON
hls-12456	158	23	division	division	NOUN
hls-12456	158	24	,	,	PUNCT
hls-12456	158	25	survival	survival	NOUN
hls-12456	158	26	,	,	PUNCT
hls-12456	158	27	and	and	CCONJ
hls-12456	158	28	migration	migration	NOUN
hls-12456	158	29	.	.	PUNCT
hls-12456	159	1	the	the	DET
hls-12456	159	2	development	development	NOUN
hls-12456	159	3	of	of	ADP
hls-12456	159	4	new	new	ADJ
hls-12456	159	5	blood	blood	NOUN
hls-12456	159	6	vessels	vessel	NOUN
hls-12456	159	7	induced	induce	VERB
hls-12456	159	8	by	by	ADP
hls-12456	159	9	the	the	DET
hls-12456	159	10	tumor	tumor	NOUN
hls-12456	159	11	(	(	PUNCT
hls-12456	159	12	angiogenesis	angiogenesis	NOUN
hls-12456	159	13	)	)	PUNCT
hls-12456	159	14	is	be	AUX
hls-12456	159	15	a	a	DET
hls-12456	159	16	key	key	ADJ
hls-12456	159	17	factor	factor	NOUN
hls-12456	159	18	supporting	support	VERB
hls-12456	159	19	tumor	tumor	NOUN
hls-12456	159	20	growth	growth	NOUN
hls-12456	159	21	and	and	CCONJ
hls-12456	159	22	metastasis	metastasis	NOUN
hls-12456	159	23	.	.	PUNCT
hls-12456	160	1	endothelial	endothelial	ADJ
hls-12456	160	2	cells	cell	NOUN
hls-12456	160	3	and	and	CCONJ
hls-12456	160	4	growth	growth	NOUN
hls-12456	160	5	factors	factor	NOUN
hls-12456	160	6	secreted	secrete	VERB
hls-12456	160	7	by	by	ADP
hls-12456	160	8	them	they	PRON
hls-12456	160	9	in	in	ADP
hls-12456	160	10	this	this	DET
hls-12456	160	11	process	process	NOUN
hls-12456	160	12	are	be	AUX
hls-12456	160	13	examples	example	NOUN
hls-12456	160	14	of	of	ADP
hls-12456	160	15	non	non	ADJ
hls-12456	160	16	-	-	ADJ
hls-12456	160	17	cell	cell	ADJ
hls-12456	160	18	autonomous	autonomous	ADJ
hls-12456	160	19	effectors	effector	NOUN
hls-12456	160	20	.	.	PUNCT
hls-12456	161	1	tumor	tumor	NOUN
hls-12456	161	2	cells	cell	NOUN
hls-12456	161	3	can	can	AUX
hls-12456	161	4	alter	alter	VERB
hls-12456	161	5	the	the	DET
hls-12456	161	6	metabolism	metabolism	NOUN
hls-12456	161	7	of	of	ADP
hls-12456	161	8	surrounding	surround	VERB
hls-12456	161	9	healthy	healthy	ADJ
hls-12456	161	10	cells	cell	NOUN
hls-12456	161	11	and	and	CCONJ
hls-12456	161	12	tissues	tissue	NOUN
hls-12456	161	13	to	to	PART
hls-12456	161	14	support	support	VERB
hls-12456	161	15	their	their	PRON
hls-12456	161	16	growth	growth	NOUN
hls-12456	161	17	and	and	CCONJ
hls-12456	161	18	survival	survival	NOUN
hls-12456	161	19	,	,	PUNCT
hls-12456	161	20	representing	represent	VERB
hls-12456	161	21	an	an	DET
hls-12456	161	22	example	example	NOUN
hls-12456	161	23	of	of	ADP
hls-12456	161	24	non	non	ADJ
hls-12456	161	25	-	-	ADJ
hls-12456	161	26	cell	cell	ADJ
hls-12456	161	27	autonomous	autonomous	ADJ
hls-12456	161	28	interaction	interaction	NOUN
hls-12456	161	29	.	.	PUNCT
hls-12456	162	1	the	the	DET
hls-12456	162	2	overall	overall	ADJ
hls-12456	162	3	state	state	NOUN
hls-12456	162	4	of	of	ADP
hls-12456	162	5	the	the	DET
hls-12456	162	6	organism	organism	NOUN
hls-12456	162	7	,	,	PUNCT
hls-12456	162	8	including	include	VERB
hls-12456	162	9	hormonal	hormonal	ADJ
hls-12456	162	10	balance	balance	NOUN
hls-12456	162	11	,	,	PUNCT
hls-12456	162	12	nutrition	nutrition	NOUN
hls-12456	162	13	,	,	PUNCT
hls-12456	162	14	and	and	CCONJ
hls-12456	162	15	general	general	ADJ
hls-12456	162	16	immune	immune	ADJ
hls-12456	162	17	status	status	NOUN
hls-12456	162	18	,	,	PUNCT
hls-12456	162	19	can	can	AUX
hls-12456	162	20	also	also	ADV
hls-12456	162	21	influence	influence	VERB
hls-12456	162	22	the	the	DET
hls-12456	162	23	patterns	pattern	NOUN
hls-12456	162	24	of	of	ADP
hls-12456	162	25	tumor	tumor	NOUN
hls-12456	162	26	cell	cell	NOUN
hls-12456	162	27	development	development	NOUN
hls-12456	162	28	.	.	PUNCT
hls-12456	163	1	researchers	researcher	NOUN
hls-12456	163	2	noted	note	VERB
hls-12456	163	3	that	that	SCONJ
hls-12456	163	4	non	non	ADJ
hls-12456	163	5	-	-	ADJ
hls-12456	163	6	cell	cell	ADJ
hls-12456	163	7	autonomous	autonomous	ADJ
hls-12456	163	8	effectors	effector	NOUN
hls-12456	163	9	could	could	AUX
hls-12456	163	10	serve	serve	VERB
hls-12456	163	11	as	as	ADP
hls-12456	163	12	the	the	DET
hls-12456	163	13	basis	basis	NOUN
hls-12456	163	14	for	for	ADP
hls-12456	163	15	developing	develop	VERB
hls-12456	163	16	innovative	innovative	ADJ
hls-12456	163	17	methods	method	NOUN
hls-12456	163	18	to	to	PART
hls-12456	163	19	combat	combat	VERB
hls-12456	163	20	oncological	oncological	ADJ
hls-12456	163	21	diseases	disease	NOUN
hls-12456	163	22	by	by	ADP
hls-12456	163	23	directly	directly	ADV
hls-12456	163	24	impacting	impact	VERB
hls-12456	163	25	both	both	DET
hls-12456	163	26	tumor	tumor	NOUN
hls-12456	163	27	cells	cell	NOUN
hls-12456	163	28	and	and	CCONJ
hls-12456	163	29	their	their	PRON
hls-12456	163	30	interaction	interaction	NOUN
hls-12456	163	31	with	with	ADP
hls-12456	163	32	the	the	DET
hls-12456	163	33	microenvironment	microenvironment	NOUN
hls-12456	163	34	.	.	PUNCT
hls-12456	164	1	therefore	therefore	ADV
hls-12456	164	2	,	,	PUNCT
hls-12456	164	3	this	this	DET
hls-12456	164	4	research	research	NOUN
hls-12456	164	5	complements	complement	VERB
hls-12456	164	6	the	the	DET
hls-12456	164	7	current	current	ADJ
hls-12456	164	8	work	work	NOUN
hls-12456	164	9	on	on	ADP
hls-12456	164	10	the	the	DET
hls-12456	164	11	mechanisms	mechanism	NOUN
hls-12456	164	12	regulating	regulate	VERB
hls-12456	164	13	tumor	tumor	NOUN
hls-12456	164	14	growth	growth	NOUN
hls-12456	164	15	and	and	CCONJ
hls-12456	164	16	metastasis	metastasis	NOUN
hls-12456	164	17	.	.	PUNCT
hls-12456	165	1	nevertheless	nevertheless	ADV
hls-12456	165	2	,	,	PUNCT
hls-12456	165	3	it	it	PRON
hls-12456	165	4	does	do	AUX
hls-12456	165	5	not	not	PART
hls-12456	165	6	allocate	allocate	VERB
hls-12456	165	7	sufficient	sufficient	ADJ
hls-12456	165	8	attention	attention	NOUN
hls-12456	165	9	to	to	ADP
hls-12456	165	10	the	the	DET
hls-12456	165	11	molecular	molecular	ADJ
hls-12456	165	12	-	-	PUNCT
hls-12456	165	13	genetic	genetic	ADJ
hls-12456	165	14	mechanisms	mechanism	NOUN
hls-12456	165	15	of	of	ADP
hls-12456	165	16	tumor	tumor	NOUN
hls-12456	165	17	cell	cell	NOUN
hls-12456	165	18	functioning	functioning	NOUN
hls-12456	165	19	.	.	PUNCT
hls-12456	166	1	studies	study	NOUN
hls-12456	166	2	in	in	ADP
hls-12456	166	3	this	this	DET
hls-12456	166	4	field	field	NOUN
hls-12456	166	5	were	be	AUX
hls-12456	166	6	also	also	ADV
hls-12456	166	7	conducted	conduct	VERB
hls-12456	166	8	by	by	ADP
hls-12456	166	9	li	li	PROPN
hls-12456	166	10	et	et	PROPN
hls-12456	166	11	al	al	PROPN
hls-12456	166	12	.	.	PROPN
hls-12456	166	13	,18	,18	PUNCT
hls-12456	166	14	focusing	focus	VERB
hls-12456	166	15	on	on	ADP
hls-12456	166	16	factors	factor	NOUN
hls-12456	166	17	stimulating	stimulate	VERB
hls-12456	166	18	the	the	DET
hls-12456	166	19	development	development	NOUN
hls-12456	166	20	and	and	CCONJ
hls-12456	166	21	further	further	ADJ
hls-12456	166	22	metastasis	metastasis	NOUN
hls-12456	166	23	of	of	ADP
hls-12456	166	24	gastrointestinal	gastrointestinal	ADJ
hls-12456	166	25	tumors	tumor	NOUN
hls-12456	166	26	.	.	PUNCT
hls-12456	167	1	in	in	ADP
hls-12456	167	2	this	this	DET
hls-12456	167	3	context	context	NOUN
hls-12456	167	4	,	,	PUNCT
hls-12456	167	5	researchers	researcher	NOUN
hls-12456	167	6	emphasized	emphasize	VERB
hls-12456	167	7	the	the	DET
hls-12456	167	8	leading	lead	VERB
hls-12456	167	9	roles	role	NOUN
hls-12456	167	10	of	of	ADP
hls-12456	167	11	immune	immune	ADJ
hls-12456	167	12	cells	cell	NOUN
hls-12456	167	13	,	,	PUNCT
hls-12456	167	14	endothelial	endothelial	ADJ
hls-12456	167	15	cells	cell	NOUN
hls-12456	167	16	,	,	PUNCT
hls-12456	167	17	and	and	CCONJ
hls-12456	167	18	fibroblasts	fibroblast	NOUN
hls-12456	167	19	.	.	PUNCT
hls-12456	168	1	regarding	regard	VERB
hls-12456	168	2	immune	immune	ADJ
hls-12456	168	3	cells	cell	NOUN
hls-12456	168	4	,	,	PUNCT
hls-12456	168	5	penetrating	penetrate	VERB
hls-12456	168	6	lymphocytes	lymphocyte	NOUN
hls-12456	168	7	(	(	PUNCT
hls-12456	168	8	pls	pls	INTJ
hls-12456	168	9	)	)	PUNCT
hls-12456	168	10	play	play	VERB
hls-12456	168	11	a	a	DET
hls-12456	168	12	significant	significant	ADJ
hls-12456	168	13	role	role	NOUN
hls-12456	168	14	,	,	PUNCT
hls-12456	168	15	participating	participate	VERB
hls-12456	168	16	in	in	ADP
hls-12456	168	17	both	both	CCONJ
hls-12456	168	18	the	the	DET
hls-12456	168	19	immune	immune	ADJ
hls-12456	168	20	masking	masking	NOUN
hls-12456	168	21	of	of	ADP
hls-12456	168	22	the	the	DET
hls-12456	168	23	tumor	tumor	NOUN
hls-12456	168	24	and	and	CCONJ
hls-12456	168	25	its	its	PRON
hls-12456	168	26	recognition	recognition	NOUN
hls-12456	168	27	,	,	PUNCT
hls-12456	168	28	destruction	destruction	NOUN
hls-12456	168	29	,	,	PUNCT
hls-12456	168	30	and	and	CCONJ
hls-12456	168	31	elimination	elimination	NOUN
hls-12456	168	32	.	.	PUNCT
hls-12456	169	1	macrophages	macrophage	NOUN
hls-12456	169	2	are	be	AUX
hls-12456	169	3	classified	classify	VERB
hls-12456	169	4	into	into	ADP
hls-12456	169	5	m1	m1	PROPN
hls-12456	169	6	and	and	CCONJ
hls-12456	169	7	m2	m2	PROPN
hls-12456	169	8	,	,	PUNCT
hls-12456	169	9	with	with	ADP
hls-12456	169	10	m1	m1	NOUN
hls-12456	169	11	macrophages	macrophage	NOUN
hls-12456	169	12	typically	typically	ADV
hls-12456	169	13	suppressing	suppress	VERB
hls-12456	169	14	the	the	DET
hls-12456	169	15	development	development	NOUN
hls-12456	169	16	of	of	ADP
hls-12456	169	17	tumor	tumor	NOUN
hls-12456	169	18	nodes	node	NOUN
hls-12456	169	19	,	,	PUNCT
hls-12456	169	20	while	while	SCONJ
hls-12456	169	21	m2	m2	PROPN
hls-12456	169	22	macrophages	macrophage	NOUN
hls-12456	169	23	promote	promote	VERB
hls-12456	169	24	tumor	tumor	NOUN
hls-12456	169	25	progression	progression	NOUN
hls-12456	169	26	by	by	ADP
hls-12456	169	27	secreting	secrete	VERB
hls-12456	169	28	growth	growth	NOUN
hls-12456	169	29	factors	factor	NOUN
hls-12456	169	30	,	,	PUNCT
hls-12456	169	31	including	include	VERB
hls-12456	169	32	those	those	PRON
hls-12456	169	33	stimulating	stimulate	VERB
hls-12456	169	34	angiogenesis	angiogenesis	NOUN
hls-12456	169	35	and	and	CCONJ
hls-12456	169	36	tumor	tumor	NOUN
hls-12456	169	37	invasion.19	invasion.19	NOUN
hls-12456	169	38	-	-	PUNCT
hls-12456	169	39	21	21	NUM
hls-12456	169	40	neutrophils	neutrophil	NOUN
hls-12456	169	41	can	can	AUX
hls-12456	169	42	both	both	CCONJ
hls-12456	169	43	promote	promote	VERB
hls-12456	169	44	and	and	CCONJ
hls-12456	169	45	inhibit	inhibit	VERB
hls-12456	169	46	the	the	DET
hls-12456	169	47	formation	formation	NOUN
hls-12456	169	48	and	and	CCONJ
hls-12456	169	49	further	further	ADJ
hls-12456	169	50	development	development	NOUN
hls-12456	169	51	of	of	ADP
hls-12456	169	52	tumors	tumor	NOUN
hls-12456	169	53	by	by	ADP
hls-12456	169	54	limiting	limit	VERB
hls-12456	169	55	the	the	DET
hls-12456	169	56	tumor	tumor	NOUN
hls-12456	169	57	microbiota	microbiota	NOUN
hls-12456	169	58	and	and	CCONJ
hls-12456	169	59	thus	thus	ADV
hls-12456	169	60	suppressing	suppress	VERB
hls-12456	169	61	the	the	DET
hls-12456	169	62	progression	progression	NOUN
hls-12456	169	63	and	and	CCONJ
hls-12456	169	64	metastasis	metastasis	NOUN
hls-12456	169	65	of	of	ADP
hls-12456	169	66	tumor	tumor	NOUN
hls-12456	169	67	cell	cell	NOUN
hls-12456	169	68	populations	population	NOUN
hls-12456	169	69	.	.	PUNCT
hls-12456	170	1	as	as	ADP
hls-12456	170	2	for	for	ADP
hls-12456	170	3	tumor	tumor	NOUN
hls-12456	170	4	-	-	PUNCT
hls-12456	170	5	associated	associate	VERB
hls-12456	170	6	fibroblasts	fibroblast	NOUN
hls-12456	170	7	(	(	PUNCT
hls-12456	170	8	tafs	tafs	NOUN
hls-12456	170	9	)	)	PUNCT
hls-12456	170	10	,	,	PUNCT
hls-12456	170	11	these	these	DET
hls-12456	170	12	cells	cell	NOUN
hls-12456	170	13	are	be	AUX
hls-12456	170	14	among	among	ADP
hls-12456	170	15	the	the	DET
hls-12456	170	16	main	main	ADJ
hls-12456	170	17	cellular	cellular	ADJ
hls-12456	170	18	components	component	NOUN
hls-12456	170	19	of	of	ADP
hls-12456	170	20	tumor	tumor	NOUN
hls-12456	170	21	growth	growth	NOUN
hls-12456	170	22	,	,	PUNCT
hls-12456	170	23	producing	produce	VERB
hls-12456	170	24	chemokines	chemokine	NOUN
hls-12456	170	25	and	and	CCONJ
hls-12456	170	26	cytokines	cytokine	NOUN
hls-12456	170	27	that	that	PRON
hls-12456	170	28	interact	interact	VERB
hls-12456	170	29	with	with	ADP
hls-12456	170	30	tumor	tumor	NOUN
hls-12456	170	31	cells	cell	NOUN
hls-12456	170	32	,	,	PUNCT
hls-12456	170	33	promoting	promote	VERB
hls-12456	170	34	angiogenesis	angiogenesis	NOUN
hls-12456	170	35	,	,	PUNCT
hls-12456	170	36	growth	growth	NOUN
hls-12456	170	37	,	,	PUNCT
hls-12456	170	38	and	and	CCONJ
hls-12456	170	39	tumor	tumor	NOUN
hls-12456	170	40	metastasis	metastasis	NOUN
hls-12456	170	41	.	.	PUNCT
hls-12456	171	1	angiogenesis	angiogenesis	NOUN
hls-12456	171	2	is	be	AUX
hls-12456	171	3	critically	critically	ADV
hls-12456	171	4	important	important	ADJ
hls-12456	171	5	for	for	ADP
hls-12456	171	6	the	the	DET
hls-12456	171	7	progression	progression	NOUN
hls-12456	171	8	of	of	ADP
hls-12456	171	9	oncological	oncological	ADJ
hls-12456	171	10	pathology	pathology	NOUN
hls-12456	171	11	.	.	PUNCT
hls-12456	172	1	this	this	DET
hls-12456	172	2	process	process	NOUN
hls-12456	172	3	is	be	AUX
hls-12456	172	4	significantly	significantly	ADV
hls-12456	172	5	influenced	influence	VERB
hls-12456	172	6	by	by	ADP
hls-12456	172	7	tumor	tumor	NOUN
hls-12456	172	8	-	-	PUNCT
hls-12456	172	9	associated	associate	VERB
hls-12456	172	10	endothelial	endothelial	NOUN
hls-12456	172	11	cells	cell	NOUN
hls-12456	172	12	(	(	PUNCT
hls-12456	172	13	taecs	taec	NOUN
hls-12456	172	14	)	)	PUNCT
hls-12456	172	15	that	that	PRON
hls-12456	172	16	produce	produce	VERB
hls-12456	172	17	growth	growth	NOUN
hls-12456	172	18	factors	factor	NOUN
hls-12456	172	19	,	,	PUNCT
hls-12456	172	20	enhancing	enhance	VERB
hls-12456	172	21	angiogenesis	angiogenesis	NOUN
hls-12456	172	22	and	and	CCONJ
hls-12456	172	23	thereby	thereby	ADV
hls-12456	172	24	promoting	promote	VERB
hls-12456	172	25	the	the	DET
hls-12456	172	26	progression	progression	NOUN
hls-12456	172	27	and	and	CCONJ
hls-12456	172	28	metastasis	metastasis	NOUN
hls-12456	172	29	of	of	ADP
hls-12456	172	30	tumors	tumor	NOUN
hls-12456	172	31	.	.	PUNCT
hls-12456	173	1	scientists	scientist	NOUN
hls-12456	173	2	have	have	AUX
hls-12456	173	3	emphasized	emphasize	VERB
hls-12456	173	4	that	that	SCONJ
hls-12456	173	5	the	the	DET
hls-12456	173	6	pathogenesis	pathogenesis	NOUN
hls-12456	173	7	of	of	ADP
hls-12456	173	8	cancer	cancer	NOUN
hls-12456	173	9	involves	involve	VERB
hls-12456	173	10	a	a	DET
hls-12456	173	11	complex	complex	ADJ
hls-12456	173	12	interaction	interaction	NOUN
hls-12456	173	13	between	between	ADP
hls-12456	173	14	tumor	tumor	NOUN
hls-12456	173	15	cells	cell	NOUN
hls-12456	173	16	and	and	CCONJ
hls-12456	173	17	their	their	PRON
hls-12456	173	18	microenvironment	microenvironment	NOUN
hls-12456	173	19	.	.	PUNCT
hls-12456	174	1	various	various	ADJ
hls-12456	174	2	components	component	NOUN
hls-12456	174	3	of	of	ADP
hls-12456	174	4	the	the	DET
hls-12456	174	5	microenvironment	microenvironment	NOUN
hls-12456	174	6	can	can	AUX
hls-12456	174	7	both	both	PRON
hls-12456	174	8	promote	promote	VERB
hls-12456	174	9	the	the	DET
hls-12456	174	10	growth	growth	NOUN
hls-12456	174	11	and	and	CCONJ
hls-12456	174	12	spread	spread	VERB
hls-12456	174	13	of	of	ADP
hls-12456	174	14	tumor	tumor	NOUN
hls-12456	174	15	cells	cell	NOUN
hls-12456	174	16	and	and	CCONJ
hls-12456	174	17	inhibit	inhibit	VERB
hls-12456	174	18	them	they	PRON
hls-12456	174	19	,	,	PUNCT
hls-12456	174	20	affecting	affect	VERB
hls-12456	174	21	the	the	DET
hls-12456	174	22	overall	overall	ADJ
hls-12456	174	23	balance	balance	NOUN
hls-12456	174	24	between	between	ADP
hls-12456	174	25	oncogenesis	oncogenesis	NOUN
hls-12456	174	26	and	and	CCONJ
hls-12456	174	27	tumor	tumor	NOUN
hls-12456	174	28	suppression	suppression	NOUN
hls-12456	174	29	.	.	PUNCT
hls-12456	175	1	while	while	SCONJ
hls-12456	175	2	this	this	DET
hls-12456	175	3	work	work	NOUN
hls-12456	175	4	complements	complement	VERB
hls-12456	175	5	existing	exist	VERB
hls-12456	175	6	data	datum	NOUN
hls-12456	175	7	on	on	ADP
hls-12456	175	8	the	the	DET
hls-12456	175	9	role	role	NOUN
hls-12456	175	10	of	of	ADP
hls-12456	175	11	intercellular	intercellular	ADJ
hls-12456	175	12	interaction	interaction	NOUN
hls-12456	175	13	in	in	ADP
hls-12456	175	14	the	the	DET
hls-12456	175	15	development	development	NOUN
hls-12456	175	16	of	of	ADP
hls-12456	175	17	gastrointestinal	gastrointestinal	ADJ
hls-12456	175	18	cancers	cancer	NOUN
hls-12456	175	19	,	,	PUNCT
hls-12456	175	20	it	it	PRON
hls-12456	175	21	lacks	lack	VERB
hls-12456	175	22	information	information	NOUN
hls-12456	175	23	on	on	ADP
hls-12456	175	24	the	the	DET
hls-12456	175	25	molecular	molecular	ADJ
hls-12456	175	26	-	-	PUNCT
hls-12456	175	27	genetic	genetic	ADJ
hls-12456	175	28	mechanisms	mechanism	NOUN
hls-12456	175	29	of	of	ADP
hls-12456	175	30	these	these	DET
hls-12456	175	31	processes	process	NOUN
hls-12456	175	32	.	.	PUNCT
hls-12456	176	1	the	the	DET
hls-12456	176	2	impact	impact	NOUN
hls-12456	176	3	of	of	ADP
hls-12456	176	4	macrophages	macrophage	NOUN
hls-12456	176	5	on	on	ADP
hls-12456	176	6	the	the	DET
hls-12456	176	7	growth	growth	NOUN
hls-12456	176	8	and	and	CCONJ
hls-12456	176	9	metastasis	metastasis	NOUN
hls-12456	176	10	of	of	ADP
hls-12456	176	11	tumor	tumor	NOUN
hls-12456	176	12	cells	cell	NOUN
hls-12456	176	13	was	be	AUX
hls-12456	176	14	also	also	ADV
hls-12456	176	15	explored	explore	VERB
hls-12456	176	16	by	by	ADP
hls-12456	176	17	fu	fu	PROPN
hls-12456	176	18	et	et	PROPN
hls-12456	176	19	al.22	al.22	NOUN
hls-12456	176	20	the	the	DET
hls-12456	176	21	researchers	researcher	NOUN
hls-12456	176	22	emphasized	emphasize	VERB
hls-12456	176	23	the	the	DET
hls-12456	176	24	existence	existence	NOUN
hls-12456	176	25	of	of	ADP
hls-12456	176	26	a	a	DET
hls-12456	176	27	distinct	distinct	ADJ
hls-12456	176	28	fraction	fraction	NOUN
hls-12456	176	29	of	of	ADP
hls-12456	176	30	macrophages	macrophage	NOUN
hls-12456	176	31	playing	play	VERB
hls-12456	176	32	a	a	DET
hls-12456	176	33	leading	lead	VERB
hls-12456	176	34	role	role	NOUN
hls-12456	176	35	in	in	ADP
hls-12456	176	36	tumor	tumor	NOUN
hls-12456	176	37	development	development	NOUN
hls-12456	176	38	,	,	PUNCT
hls-12456	176	39	known	know	VERB
hls-12456	176	40	as	as	ADP
hls-12456	176	41	tumorassociated	tumorassociate	VERB
hls-12456	176	42	macrophages	macrophage	NOUN
hls-12456	176	43	(	(	PUNCT
hls-12456	176	44	tams	tam	NOUN
hls-12456	176	45	)	)	PUNCT
hls-12456	176	46	.	.	PUNCT
hls-12456	177	1	tams	tam	NOUN
hls-12456	177	2	create	create	VERB
hls-12456	177	3	an	an	DET
hls-12456	177	4	immunosuppressive	immunosuppressive	ADJ
hls-12456	177	5	environment	environment	NOUN
hls-12456	177	6	around	around	ADP
hls-12456	177	7	tumor	tumor	NOUN
hls-12456	177	8	cell	cell	NOUN
hls-12456	177	9	populations	population	NOUN
hls-12456	177	10	by	by	ADP
hls-12456	177	11	producing	produce	VERB
hls-12456	177	12	signaling	signal	VERB
hls-12456	177	13	molecules	molecule	NOUN
hls-12456	177	14	that	that	PRON
hls-12456	177	15	inhibit	inhibit	VERB
hls-12456	177	16	anti	anti	ADJ
hls-12456	177	17	-	-	ADJ
hls-12456	177	18	tumor	tumor	ADJ
hls-12456	177	19	cellular	cellular	ADJ
hls-12456	177	20	and	and	CCONJ
hls-12456	177	21	humoral	humoral	ADJ
hls-12456	177	22	responses	response	NOUN
hls-12456	177	23	.	.	PUNCT
hls-12456	178	1	importantly	importantly	ADV
hls-12456	178	2	,	,	PUNCT
hls-12456	178	3	the	the	DET
hls-12456	178	4	concentration	concentration	NOUN
hls-12456	178	5	of	of	ADP
hls-12456	178	6	tams	tam	NOUN
hls-12456	178	7	increases	increase	VERB
hls-12456	178	8	proportionally	proportionally	ADV
hls-12456	178	9	with	with	ADP
hls-12456	178	10	tumor	tumor	NOUN
hls-12456	178	11	development	development	NOUN
hls-12456	178	12	and	and	CCONJ
hls-12456	178	13	is	be	AUX
hls-12456	178	14	associated	associate	VERB
hls-12456	178	15	with	with	ADP
hls-12456	178	16	unfavorable	unfavorable	ADJ
hls-12456	178	17	clinical	clinical	ADJ
hls-12456	178	18	outcomes	outcome	NOUN
hls-12456	178	19	.	.	PUNCT
hls-12456	179	1	tams	tam	NOUN
hls-12456	179	2	also	also	ADV
hls-12456	179	3	participate	participate	VERB
hls-12456	179	4	in	in	ADP
hls-12456	179	5	angiogenesis	angiogenesis	NOUN
hls-12456	179	6	through	through	ADP
hls-12456	179	7	factors	factor	NOUN
hls-12456	179	8	such	such	ADJ
hls-12456	179	9	as	as	ADP
hls-12456	179	10	vascular	vascular	ADJ
hls-12456	179	11	endothelial	endothelial	ADJ
hls-12456	179	12	growth	growth	NOUN
hls-12456	179	13	factor	factor	NOUN
hls-12456	179	14	a	a	DET
hls-12456	179	15	(	(	PUNCT
hls-12456	179	16	vegf	vegf	NOUN
hls-12456	179	17	-	-	PUNCT
hls-12456	179	18	a	a	NOUN
hls-12456	179	19	)	)	PUNCT
hls-12456	179	20	,	,	PUNCT
hls-12456	179	21	placental	placental	ADJ
hls-12456	179	22	growth	growth	NOUN
hls-12456	179	23	factor	factor	NOUN
hls-12456	179	24	(	(	PUNCT
hls-12456	179	25	plgf	plgf	NOUN
hls-12456	179	26	)	)	PUNCT
hls-12456	179	27	,	,	PUNCT
hls-12456	179	28	interleukin	interleukin	NOUN
hls-12456	179	29	1	1	NUM
hls-12456	179	30	beta	beta	NOUN
hls-12456	179	31	(	(	PUNCT
hls-12456	179	32	il-1β	il-1β	PROPN
hls-12456	179	33	)	)	PUNCT
hls-12456	179	34	,	,	PUNCT
hls-12456	179	35	epidermal	epidermal	ADJ
hls-12456	179	36	growth	growth	NOUN
hls-12456	179	37	factor	factor	NOUN
hls-12456	179	38	(	(	PUNCT
hls-12456	179	39	egf	egf	PROPN
hls-12456	179	40	)	)	PUNCT
hls-12456	179	41	,	,	PUNCT
hls-12456	179	42	tumor	tumor	NOUN
hls-12456	179	43	necrosis	necrosis	NOUN
hls-12456	179	44	factor	factor	NOUN
hls-12456	179	45	alpha	alpha	NOUN
hls-12456	179	46	(	(	PUNCT
hls-12456	179	47	tnf	tnf	PROPN
hls-12456	179	48	-	-	PUNCT
hls-12456	179	49	α	α	NOUN
hls-12456	179	50	)	)	PUNCT
hls-12456	179	51	,	,	PUNCT
hls-12456	179	52	transforming	transform	VERB
hls-12456	179	53	growth	growth	NOUN
hls-12456	179	54	factor	factor	NOUN
hls-12456	179	55	beta	beta	NOUN
hls-12456	179	56	(	(	PUNCT
hls-12456	179	57	tgf	tgf	PROPN
hls-12456	179	58	-	-	PUNCT
hls-12456	179	59	β	β	NOUN
hls-12456	179	60	)	)	PUNCT
hls-12456	179	61	,	,	PUNCT
hls-12456	179	62	interleukin	interleukin	NOUN
hls-12456	179	63	8	8	NUM
hls-12456	179	64	(	(	PUNCT
hls-12456	179	65	il-8	il-8	NUM
hls-12456	179	66	)	)	PUNCT
hls-12456	179	67	,	,	PUNCT
hls-12456	179	68	cxcl8	cxcl8	PROPN
hls-12456	179	69	,	,	PUNCT
hls-12456	179	70	chemokine	chemokine	ADJ
hls-12456	179	71	ligand	ligand	NOUN
hls-12456	179	72	2	2	NUM
hls-12456	179	73	(	(	PUNCT
hls-12456	179	74	ccl2	ccl2	PROPN
hls-12456	179	75	)	)	PUNCT
hls-12456	179	76	,	,	PUNCT
hls-12456	179	77	and	and	CCONJ
hls-12456	179	78	cxcl12	cxcl12	ADJ
hls-12456	179	79	.	.	PUNCT
hls-12456	180	1	tams	tam	NOUN
hls-12456	180	2	play	play	VERB
hls-12456	180	3	a	a	DET
hls-12456	180	4	crucial	crucial	ADJ
hls-12456	180	5	role	role	NOUN
hls-12456	180	6	in	in	ADP
hls-12456	180	7	the	the	DET
hls-12456	180	8	metastatic	metastatic	ADJ
hls-12456	180	9	process	process	NOUN
hls-12456	180	10	by	by	ADP
hls-12456	180	11	forming	form	VERB
hls-12456	180	12	premetastatic	premetastatic	ADJ
hls-12456	180	13	niches	niche	NOUN
hls-12456	180	14	and	and	CCONJ
hls-12456	180	15	stimulating	stimulate	VERB
hls-12456	180	16	epithelial	epithelial	ADJ
hls-12456	180	17	-	-	PUNCT
hls-12456	180	18	mesenchymal	mesenchymal	ADJ
hls-12456	180	19	transitions	transition	NOUN
hls-12456	180	20	,	,	PUNCT
hls-12456	180	21	enhancing	enhance	VERB
hls-12456	180	22	the	the	DET
hls-12456	180	23	invasion	invasion	NOUN
hls-12456	180	24	of	of	ADP
hls-12456	180	25	tumor	tumor	NOUN
hls-12456	180	26	cells	cell	NOUN
hls-12456	180	27	.	.	PUNCT
hls-12456	181	1	thus	thus	ADV
hls-12456	181	2	,	,	PUNCT
hls-12456	181	3	the	the	DET
hls-12456	181	4	provided	provide	VERB
hls-12456	181	5	material	material	NOUN
hls-12456	181	6	complements	complement	NOUN
hls-12456	181	7	research	research	NOUN
hls-12456	181	8	on	on	ADP
hls-12456	181	9	the	the	DET
hls-12456	181	10	influence	influence	NOUN
hls-12456	181	11	of	of	ADP
hls-12456	181	12	tams	tam	NOUN
hls-12456	181	13	on	on	ADP
hls-12456	181	14	oncogenesis	oncogenesis	NOUN
hls-12456	181	15	and	and	CCONJ
hls-12456	181	16	metastasis	metastasis	NOUN
hls-12456	181	17	.	.	PUNCT
hls-12456	182	1	regarding	regard	VERB
hls-12456	182	2	the	the	DET
hls-12456	182	3	molecular	molecular	ADJ
hls-12456	182	4	-	-	PUNCT
hls-12456	182	5	genetic	genetic	ADJ
hls-12456	182	6	aspect	aspect	NOUN
hls-12456	182	7	of	of	ADP
hls-12456	182	8	metastasis	metastasis	NOUN
hls-12456	182	9	and	and	CCONJ
hls-12456	182	10	oncogenesis	oncogenesis	NOUN
hls-12456	182	11	,	,	PUNCT
hls-12456	182	12	significant	significant	ADJ
hls-12456	182	13	contributions	contribution	NOUN
hls-12456	182	14	were	be	AUX
hls-12456	182	15	made	make	VERB
hls-12456	182	16	by	by	ADP
hls-12456	182	17	abdi	abdi	PROPN
hls-12456	182	18	and	and	CCONJ
hls-12456	182	19	latifi	latifi	PROPN
hls-12456	182	20	-	-	PUNCT
hls-12456	182	21	navid,23	navid,23	NOUN
hls-12456	182	22	who	who	PRON
hls-12456	182	23	examined	examine	VERB
hls-12456	182	24	the	the	DET
hls-12456	182	25	role	role	NOUN
hls-12456	182	26	of	of	ADP
hls-12456	182	27	long	long	ADJ
hls-12456	182	28	non	non	ADJ
hls-12456	182	29	-	-	ADJ
hls-12456	182	30	coding	coding	ADJ
hls-12456	182	31	rnas	rna	NOUN
hls-12456	182	32	(	(	PUNCT
hls-12456	182	33	lncrnas	lncrnas	PROPN
hls-12456	182	34	)	)	PUNCT
hls-12456	182	35	and	and	CCONJ
hls-12456	182	36	single	single	ADJ
hls-12456	182	37	nucleotide	nucleotide	ADJ
hls-12456	182	38	polymorphisms	polymorphism	NOUN
hls-12456	182	39	(	(	PUNCT
hls-12456	182	40	snps	snps	PROPN
hls-12456	182	41	)	)	PUNCT
hls-12456	182	42	in	in	ADP
hls-12456	182	43	this	this	DET
hls-12456	182	44	context	context	NOUN
hls-12456	182	45	.	.	PUNCT
hls-12456	183	1	lncrnas	lncrnas	PROPN
hls-12456	183	2	are	be	AUX
hls-12456	183	3	sequences	sequence	NOUN
hls-12456	183	4	of	of	ADP
hls-12456	183	5	over	over	ADP
hls-12456	183	6	200	200	NUM
hls-12456	183	7	nucleotides	nucleotide	NOUN
hls-12456	183	8	that	that	PRON
hls-12456	183	9	do	do	AUX
hls-12456	183	10	not	not	PART
hls-12456	183	11	encode	encode	VERB
hls-12456	183	12	proteins	protein	NOUN
hls-12456	183	13	but	but	CCONJ
hls-12456	183	14	serve	serve	VERB
hls-12456	183	15	various	various	ADJ
hls-12456	183	16	regulatory	regulatory	ADJ
hls-12456	183	17	functions	function	NOUN
hls-12456	183	18	.	.	PUNCT
hls-12456	184	1	these	these	DET
hls-12456	184	2	rnas	rna	NOUN
hls-12456	184	3	can	can	AUX
hls-12456	184	4	act	act	VERB
hls-12456	184	5	as	as	ADP
hls-12456	184	6	oncogenic	oncogenic	ADJ
hls-12456	184	7	factors	factor	NOUN
hls-12456	184	8	or	or	CCONJ
hls-12456	184	9	tumor	tumor	NOUN
hls-12456	184	10	suppressors	suppressor	NOUN
hls-12456	184	11	in	in	ADP
hls-12456	184	12	different	different	ADJ
hls-12456	184	13	types	type	NOUN
hls-12456	184	14	of	of	ADP
hls-12456	184	15	cancer	cancer	NOUN
hls-12456	184	16	.	.	PUNCT
hls-12456	185	1	they	they	PRON
hls-12456	185	2	are	be	AUX
hls-12456	185	3	categorized	categorize	VERB
hls-12456	185	4	into	into	ADP
hls-12456	185	5	pseudogenes	pseudogene	NOUN
hls-12456	185	6	,	,	PUNCT
hls-12456	185	7	signaling	signal	VERB
hls-12456	185	8	,	,	PUNCT
hls-12456	185	9	guiding	guiding	NOUN
hls-12456	185	10	,	,	PUNCT
hls-12456	185	11	and	and	CCONJ
hls-12456	185	12	scaffold	scaffold	NOUN
hls-12456	185	13	lncrnas	lncrna	NOUN
hls-12456	185	14	based	base	VERB
hls-12456	185	15	on	on	ADP
hls-12456	185	16	their	their	PRON
hls-12456	185	17	molecular	molecular	ADJ
hls-12456	185	18	mechanisms	mechanism	NOUN
hls-12456	185	19	of	of	ADP
hls-12456	185	20	action	action	NOUN
hls-12456	185	21	.	.	PUNCT
hls-12456	186	1	signaling	signal	VERB
hls-12456	186	2	lncrnas	lncrna	NOUN
hls-12456	186	3	,	,	PUNCT
hls-12456	186	4	crucial	crucial	ADJ
hls-12456	186	5	in	in	ADP
hls-12456	186	6	this	this	DET
hls-12456	186	7	context	context	NOUN
hls-12456	186	8	,	,	PUNCT
hls-12456	186	9	can	can	AUX
hls-12456	186	10	activate	activate	VERB
hls-12456	186	11	or	or	CCONJ
hls-12456	186	12	suppress	suppress	VERB
hls-12456	186	13	other	other	ADJ
hls-12456	186	14	transcripts	transcript	NOUN
hls-12456	186	15	and	and	CCONJ
hls-12456	186	16	exhibit	exhibit	NOUN
hls-12456	186	17	expression	expression	NOUN
hls-12456	186	18	specificity	specificity	NOUN
hls-12456	186	19	depending	depend	VERB
hls-12456	186	20	on	on	ADP
hls-12456	186	21	the	the	DET
hls-12456	186	22	cell	cell	NOUN
hls-12456	186	23	type	type	NOUN
hls-12456	186	24	.	.	PUNCT
hls-12456	187	1	they	they	PRON
hls-12456	187	2	can	can	AUX
hls-12456	187	3	compete	compete	VERB
hls-12456	187	4	with	with	ADP
hls-12456	187	5	transcription	transcription	NOUN
hls-12456	187	6	factors	factor	NOUN
hls-12456	187	7	and	and	CCONJ
hls-12456	187	8	rna	rna	NOUN
hls-12456	187	9	-	-	PUNCT
hls-12456	187	10	binding	bind	VERB
hls-12456	187	11	proteins	protein	NOUN
hls-12456	187	12	,	,	PUNCT
hls-12456	187	13	influencing	influence	VERB
hls-12456	187	14	processes	process	NOUN
hls-12456	187	15	such	such	ADJ
hls-12456	187	16	as	as	ADP
hls-12456	187	17	cell	cell	NOUN
hls-12456	187	18	proliferation	proliferation	NOUN
hls-12456	187	19	,	,	PUNCT
hls-12456	187	20	differentiation	differentiation	NOUN
hls-12456	187	21	,	,	PUNCT
hls-12456	187	22	angiogenesis	angiogenesis	NOUN
hls-12456	187	23	,	,	PUNCT
hls-12456	187	24	metastasis	metastasis	NOUN
hls-12456	187	25	,	,	PUNCT
hls-12456	187	26	and	and	CCONJ
hls-12456	187	27	chemotherapy	chemotherapy	NOUN
hls-12456	187	28	resistance	resistance	NOUN
hls-12456	187	29	.	.	PUNCT
hls-12456	188	1	in	in	ADP
hls-12456	188	2	terms	term	NOUN
hls-12456	188	3	of	of	ADP
hls-12456	188	4	the	the	DET
hls-12456	188	5	interaction	interaction	NOUN
hls-12456	188	6	between	between	ADP
hls-12456	188	7	snps	snps	PROPN
hls-12456	188	8	and	and	CCONJ
hls-12456	188	9	lncrnas	lncrna	NOUN
hls-12456	188	10	,	,	PUNCT
hls-12456	188	11	the	the	DET
hls-12456	188	12	latter	latter	ADJ
hls-12456	188	13	can	can	AUX
hls-12456	188	14	affect	affect	VERB
hls-12456	188	15	the	the	DET
hls-12456	188	16	function	function	NOUN
hls-12456	188	17	and	and	CCONJ
hls-12456	188	18	structure	structure	NOUN
hls-12456	188	19	of	of	ADP
hls-12456	188	20	snps	snps	PROPN
hls-12456	188	21	,	,	PUNCT
hls-12456	188	22	altering	alter	VERB
hls-12456	188	23	their	their	PRON
hls-12456	188	24	interaction	interaction	NOUN
hls-12456	188	25	with	with	ADP
hls-12456	188	26	messenger	messenger	NOUN
hls-12456	188	27	rnas	rnas	PROPN
hls-12456	188	28	(	(	PUNCT
hls-12456	188	29	mrnas	mrnas	PROPN
hls-12456	188	30	)	)	PUNCT
hls-12456	188	31	.	.	PUNCT
hls-12456	189	1	researchers	researcher	NOUN
hls-12456	189	2	emphasized	emphasize	VERB
hls-12456	189	3	that	that	SCONJ
hls-12456	189	4	lncrnas	lncrna	NOUN
hls-12456	189	5	can	can	AUX
hls-12456	189	6	serve	serve	VERB
hls-12456	189	7	as	as	ADP
hls-12456	189	8	targets	target	NOUN
hls-12456	189	9	for	for	ADP
hls-12456	189	10	chemotherapy	chemotherapy	NOUN
hls-12456	189	11	and	and	CCONJ
hls-12456	189	12	potential	potential	ADJ
hls-12456	189	13	targets	target	NOUN
hls-12456	189	14	for	for	ADP
hls-12456	189	15	oncological	oncological	ADJ
hls-12456	189	16	preventive	preventive	ADJ
hls-12456	189	17	interventions.24	interventions.24	NOUN
hls-12456	189	18	therefore	therefore	ADV
hls-12456	189	19	,	,	PUNCT
hls-12456	189	20	this	this	DET
hls-12456	189	21	study	study	NOUN
hls-12456	189	22	complements	complement	VERB
hls-12456	189	23	existing	exist	VERB
hls-12456	189	24	knowledge	knowledge	NOUN
hls-12456	189	25	about	about	ADP
hls-12456	189	26	the	the	DET
hls-12456	189	27	molecular	molecular	ADJ
hls-12456	189	28	-	-	PUNCT
hls-12456	189	29	genetic	genetic	ADJ
hls-12456	189	30	characteristics	characteristic	NOUN
hls-12456	189	31	of	of	ADP
hls-12456	189	32	tumor	tumor	NOUN
hls-12456	189	33	processes	process	NOUN
hls-12456	189	34	,	,	PUNCT
hls-12456	189	35	although	although	SCONJ
hls-12456	189	36	the	the	DET
hls-12456	189	37	focus	focus	NOUN
hls-12456	189	38	on	on	ADP
hls-12456	189	39	lncrnas	lncrna	NOUN
hls-12456	189	40	has	have	AUX
hls-12456	189	41	led	lead	VERB
hls-12456	189	42	to	to	ADP
hls-12456	189	43	insufficient	insufficient	ADJ
hls-12456	189	44	coverage	coverage	NOUN
hls-12456	189	45	of	of	ADP
hls-12456	189	46	dna	dna	PROPN
hls-12456	189	47	changes	change	NOUN
hls-12456	189	48	during	during	ADP
hls-12456	189	49	the	the	DET
hls-12456	189	50	tumor	tumor	NOUN
hls-12456	189	51	process	process	NOUN
hls-12456	189	52	.	.	PUNCT
hls-12456	190	1	expanding	expand	VERB
hls-12456	190	2	on	on	ADP
hls-12456	190	3	the	the	DET
hls-12456	190	4	topic	topic	NOUN
hls-12456	190	5	of	of	ADP
hls-12456	190	6	molecular	molecular	ADJ
hls-12456	190	7	-	-	PUNCT
hls-12456	190	8	genetic	genetic	ADJ
hls-12456	190	9	determinants	determinant	NOUN
hls-12456	190	10	of	of	ADP
hls-12456	190	11	oncological	oncological	ADJ
hls-12456	190	12	processes	process	NOUN
hls-12456	190	13	,	,	PUNCT
hls-12456	190	14	it	it	PRON
hls-12456	190	15	is	be	AUX
hls-12456	190	16	worth	worth	ADJ
hls-12456	190	17	paying	pay	VERB
hls-12456	190	18	attention	attention	NOUN
hls-12456	190	19	to	to	ADP
hls-12456	190	20	mrnas	mrnas	PROPN
hls-12456	190	21	.	.	PUNCT
hls-12456	191	1	in	in	ADP
hls-12456	191	2	their	their	PRON
hls-12456	191	3	study	study	NOUN
hls-12456	191	4	,	,	PUNCT
hls-12456	191	5	mazziotta	mazziotta	PROPN
hls-12456	191	6	et	et	PROPN
hls-12456	191	7	al.25	al.25	ADV
hls-12456	191	8	investigated	investigate	VERB
hls-12456	191	9	these	these	DET
hls-12456	191	10	sequences	sequence	NOUN
hls-12456	191	11	in	in	ADP
hls-12456	191	12	the	the	DET
hls-12456	191	13	context	context	NOUN
hls-12456	191	14	of	of	ADP
hls-12456	191	15	signaling	signal	VERB
hls-12456	191	16	pathways	pathway	NOUN
hls-12456	191	17	related	relate	VERB
hls-12456	191	18	to	to	ADP
hls-12456	191	19	the	the	DET
hls-12456	191	20	growth	growth	NOUN
hls-12456	191	21	and	and	CCONJ
hls-12456	191	22	differentiation	differentiation	NOUN
hls-12456	191	23	of	of	ADP
hls-12456	191	24	cell	cell	NOUN
hls-12456	191	25	populations	population	NOUN
hls-12456	191	26	.	.	PUNCT
hls-12456	192	1	mrnas	mrna	NOUN
hls-12456	192	2	are	be	AUX
hls-12456	192	3	a	a	DET
hls-12456	192	4	class	class	NOUN
hls-12456	192	5	of	of	ADP
hls-12456	192	6	non	non	ADJ
hls-12456	192	7	-	-	ADJ
hls-12456	192	8	coding	coding	ADJ
hls-12456	192	9	rnas	rna	NOUN
hls-12456	192	10	that	that	PRON
hls-12456	192	11	play	play	VERB
hls-12456	192	12	a	a	DET
hls-12456	192	13	crucial	crucial	ADJ
hls-12456	192	14	role	role	NOUN
hls-12456	192	15	in	in	ADP
hls-12456	192	16	regulating	regulate	VERB
hls-12456	192	17	gene	gene	NOUN
hls-12456	192	18	expression	expression	NOUN
hls-12456	192	19	.	.	PUNCT
hls-12456	193	1	they	they	PRON
hls-12456	193	2	constitute	constitute	VERB
hls-12456	193	3	1	1	NUM
hls-12456	193	4	to	to	PART
hls-12456	193	5	5	5	NUM
hls-12456	193	6	%	%	NOUN
hls-12456	193	7	of	of	ADP
hls-12456	193	8	the	the	DET
hls-12456	193	9	human	human	ADJ
hls-12456	193	10	genome	genome	NOUN
hls-12456	193	11	and	and	CCONJ
hls-12456	193	12	influence	influence	VERB
hls-12456	193	13	the	the	DET
hls-12456	193	14	regulation	regulation	NOUN
hls-12456	193	15	of	of	ADP
hls-12456	193	16	30	30	NUM
hls-12456	193	17	to	to	PART
hls-12456	193	18	60	60	NUM
hls-12456	193	19	%	%	NOUN
hls-12456	193	20	of	of	ADP
hls-12456	193	21	protein	protein	NOUN
hls-12456	193	22	-	-	PUNCT
hls-12456	193	23	coding	code	VERB
hls-12456	193	24	genes	gene	NOUN
hls-12456	193	25	.	.	PUNCT
hls-12456	194	1	the	the	DET
hls-12456	194	2	impact	impact	NOUN
hls-12456	194	3	of	of	ADP
hls-12456	194	4	mrnas	mrna	NOUN
hls-12456	194	5	on	on	ADP
hls-12456	194	6	signaling	signal	VERB
hls-12456	194	7	pathways	pathway	NOUN
hls-12456	194	8	is	be	AUX
hls-12456	194	9	crucial	crucial	ADJ
hls-12456	194	10	for	for	ADP
hls-12456	194	11	understanding	understand	VERB
hls-12456	194	12	the	the	DET
hls-12456	194	13	mechanisms	mechanism	NOUN
hls-12456	194	14	of	of	ADP
hls-12456	194	15	differentiation	differentiation	NOUN
hls-12456	194	16	and	and	CCONJ
hls-12456	194	17	tumor	tumor	NOUN
hls-12456	194	18	growth	growth	NOUN
hls-12456	194	19	,	,	PUNCT
hls-12456	194	20	particularly	particularly	ADV
hls-12456	194	21	through	through	ADP
hls-12456	194	22	fundamental	fundamental	ADJ
hls-12456	194	23	signaling	signal	VERB
hls-12456	194	24	pathways	pathway	NOUN
hls-12456	194	25	such	such	ADJ
hls-12456	194	26	as	as	ADP
hls-12456	194	27	transforming	transform	VERB
hls-12456	194	28	growth	growth	NOUN
hls-12456	194	29	factor	factor	NOUN
hls-12456	194	30	beta	beta	NOUN
hls-12456	194	31	bone	bone	NOUN
hls-12456	194	32	morphogenetic	morphogenetic	ADJ
hls-12456	194	33	protein	protein	NOUN
hls-12456	194	34	(	(	PUNCT
hls-12456	194	35	tgf	tgf	PROPN
hls-12456	194	36	-	-	PUNCT
hls-12456	194	37	β	β	NOUN
hls-12456	194	38	/	/	SYM
hls-12456	194	39	bmp	bmp	NOUN
hls-12456	194	40	)	)	PUNCT
hls-12456	194	41	and	and	CCONJ
hls-12456	194	42	wnt	wnt	PROPN
hls-12456	194	43	/	/	SYM
hls-12456	194	44	β	β	NOUN
hls-12456	194	45	-	-	NOUN
hls-12456	194	46	catenin	catenin	NOUN
hls-12456	194	47	.	.	PUNCT
hls-12456	195	1	in	in	ADP
hls-12456	195	2	the	the	DET
hls-12456	195	3	tgf	tgf	PROPN
hls-12456	195	4	-	-	PUNCT
hls-12456	195	5	β	β	NOUN
hls-12456	195	6	/	/	SYM
hls-12456	195	7	bmp	bmp	NOUN
hls-12456	195	8	signaling	signal	VERB
hls-12456	195	9	pathway	pathway	NOUN
hls-12456	195	10	,	,	PUNCT
hls-12456	195	11	mrnas	mrna	NOUN
hls-12456	195	12	regulate	regulate	VERB
hls-12456	195	13	receptors	receptor	NOUN
hls-12456	195	14	social	social	ADJ
hls-12456	195	15	and	and	CCONJ
hls-12456	195	16	political	political	ADJ
hls-12456	195	17	factors	factor	NOUN
hls-12456	195	18	affecting	affect	VERB
hls-12456	195	19	public	public	ADJ
hls-12456	195	20	health	health	NOUN
hls-12456	196	1	[	[	X
hls-12456	196	2	page	page	NOUN
hls-12456	196	3	80	80	NUM
hls-12456	196	4	]	]	PUNCT
hls-12456	197	1	[	[	X
hls-12456	197	2	healthcare	healthcare	NOUN
hls-12456	197	3	in	in	ADP
hls-12456	197	4	low	low	ADJ
hls-12456	197	5	-	-	PUNCT
hls-12456	197	6	resource	resource	NOUN
hls-12456	197	7	settings	setting	NOUN
hls-12456	197	8	2024;12(s2):12456	2024;12(s2):12456	NUM
hls-12456	197	9	]	]	X
hls-12456	197	10	non	non	ADJ
hls-12456	197	11	-co	-co	PROPN
hls-12456	197	12	mmerc	mmerc	PROPN
hls-12456	197	13	ial	ial	PROPN
hls-12456	197	14	us	us	PROPN
hls-12456	197	15	e	e	NOUN
hls-12456	197	16	o	o	NOUN
hls-12456	197	17	nly	nly	ADV
hls-12456	197	18	and	and	CCONJ
hls-12456	197	19	ligands	ligand	NOUN
hls-12456	197	20	of	of	ADP
hls-12456	197	21	bmp	bmp	PROPN
hls-12456	197	22	and	and	CCONJ
hls-12456	197	23	tgf	tgf	PROPN
hls-12456	197	24	-	-	PUNCT
hls-12456	197	25	β	β	PROPN
hls-12456	197	26	,	,	PUNCT
hls-12456	197	27	influencing	influence	VERB
hls-12456	197	28	the	the	DET
hls-12456	197	29	development	development	NOUN
hls-12456	197	30	patterns	pattern	NOUN
hls-12456	197	31	of	of	ADP
hls-12456	197	32	tumor	tumor	NOUN
hls-12456	197	33	cells	cell	NOUN
hls-12456	197	34	.	.	PUNCT
hls-12456	198	1	for	for	ADP
hls-12456	198	2	example	example	NOUN
hls-12456	198	3	,	,	PUNCT
hls-12456	198	4	mrnas	mrna	NOUN
hls-12456	198	5	such	such	ADJ
hls-12456	198	6	as	as	ADP
hls-12456	198	7	mrna-153	mrna-153	NOUN
hls-12456	198	8	and	and	CCONJ
hls-12456	198	9	mrna-100	mrna-100	NOUN
hls-12456	198	10	selectively	selectively	ADV
hls-12456	198	11	affect	affect	VERB
hls-12456	198	12	bmp	bmp	PROPN
hls-12456	198	13	type	type	PROPN
hls-12456	198	14	ii	ii	PROPN
hls-12456	198	15	receptor	receptor	NOUN
hls-12456	198	16	(	(	PUNCT
hls-12456	198	17	bmpr2	bmpr2	NOUN
hls-12456	198	18	)	)	PUNCT
hls-12456	198	19	,	,	PUNCT
hls-12456	198	20	while	while	SCONJ
hls-12456	198	21	mrna-195	mrna-195	ADJ
hls-12456	198	22	-	-	PUNCT
hls-12456	198	23	5p	5p	PROPN
hls-12456	198	24	affects	affect	VERB
hls-12456	198	25	bmp	bmp	PROPN
hls-12456	198	26	type	type	NOUN
hls-12456	198	27	ia	ia	PROPN
hls-12456	198	28	receptor	receptor	NOUN
hls-12456	198	29	(	(	PUNCT
hls-12456	198	30	bmpr1a	bmpr1a	NOUN
hls-12456	198	31	)	)	PUNCT
hls-12456	198	32	,	,	PUNCT
hls-12456	198	33	modulating	modulate	VERB
hls-12456	198	34	the	the	DET
hls-12456	198	35	growth	growth	NOUN
hls-12456	198	36	and	and	CCONJ
hls-12456	198	37	development	development	NOUN
hls-12456	198	38	of	of	ADP
hls-12456	198	39	undifferentiated	undifferentiated	ADJ
hls-12456	198	40	cell	cell	NOUN
hls-12456	198	41	populations	population	NOUN
hls-12456	198	42	.	.	PUNCT
hls-12456	199	1	in	in	ADP
hls-12456	199	2	the	the	DET
hls-12456	199	3	tgf	tgf	PROPN
hls-12456	199	4	-	-	PUNCT
hls-12456	199	5	β	β	PROPN
hls-12456	199	6	signaling	signal	VERB
hls-12456	199	7	pathway	pathway	NOUN
hls-12456	199	8	,	,	PUNCT
hls-12456	199	9	mrnas	mrna	NOUN
hls-12456	199	10	such	such	ADJ
hls-12456	199	11	as	as	ADP
hls-12456	199	12	mrna-10b	mrna-10b	PROPN
hls-12456	199	13	,	,	PUNCT
hls-12456	199	14	which	which	PRON
hls-12456	199	15	promote	promote	VERB
hls-12456	199	16	cell	cell	NOUN
hls-12456	199	17	growth	growth	NOUN
hls-12456	199	18	and	and	CCONJ
hls-12456	199	19	differentiation	differentiation	NOUN
hls-12456	199	20	,	,	PUNCT
hls-12456	199	21	are	be	AUX
hls-12456	199	22	targeted	target	VERB
hls-12456	199	23	at	at	ADP
hls-12456	199	24	smad2	smad2	PROPN
hls-12456	199	25	,	,	PUNCT
hls-12456	199	26	while	while	SCONJ
hls-12456	199	27	mrna-221	mrna-221	NOUN
hls-12456	199	28	-	-	PUNCT
hls-12456	199	29	5p	5p	NUM
hls-12456	199	30	and	and	CCONJ
hls-12456	199	31	mrna-708	mrna-708	ADJ
hls-12456	199	32	inhibit	inhibit	NOUN
hls-12456	199	33	cell	cell	NOUN
hls-12456	199	34	growth	growth	NOUN
hls-12456	199	35	and	and	CCONJ
hls-12456	199	36	differentiation	differentiation	NOUN
hls-12456	199	37	,	,	PUNCT
hls-12456	199	38	affecting	affect	VERB
hls-12456	199	39	smad3	smad3	NOUN
hls-12456	199	40	.	.	PUNCT
hls-12456	200	1	in	in	ADP
hls-12456	200	2	the	the	DET
hls-12456	200	3	wnt	wnt	PROPN
hls-12456	200	4	/	/	SYM
hls-12456	200	5	βcatenin	βcatenin	NOUN
hls-12456	200	6	signaling	signal	VERB
hls-12456	200	7	pathway	pathway	NOUN
hls-12456	200	8	,	,	PUNCT
hls-12456	200	9	mrnas	mrna	NOUN
hls-12456	200	10	such	such	ADJ
hls-12456	200	11	as	as	ADP
hls-12456	200	12	mrna-1297	mrna-1297	NOUN
hls-12456	200	13	,	,	PUNCT
hls-12456	200	14	mrna9	mrna9	NOUN
hls-12456	200	15	-	-	PUNCT
hls-12456	200	16	5p	5p	NUM
hls-12456	200	17	,	,	PUNCT
hls-12456	200	18	mrna-16	mrna-16	NOUN
hls-12456	200	19	-	-	PUNCT
hls-12456	200	20	2	2	NUM
hls-12456	200	21	-	-	PUNCT
hls-12456	200	22	3p	3p	NUM
hls-12456	200	23	regulate	regulate	VERB
hls-12456	200	24	wnt	wnt	NOUN
hls-12456	200	25	receptors	receptor	NOUN
hls-12456	200	26	and	and	CCONJ
hls-12456	200	27	ligands	ligand	NOUN
hls-12456	200	28	,	,	PUNCT
hls-12456	200	29	including	include	VERB
hls-12456	200	30	wnt3a	wnt3a	PROPN
hls-12456	200	31	and	and	CCONJ
hls-12456	200	32	wnt5a	wnt5a	PROPN
hls-12456	200	33	,	,	PUNCT
hls-12456	200	34	influencing	influence	VERB
hls-12456	200	35	the	the	DET
hls-12456	200	36	development	development	NOUN
hls-12456	200	37	patterns	pattern	NOUN
hls-12456	200	38	of	of	ADP
hls-12456	200	39	undifferentiated	undifferentiated	ADJ
hls-12456	200	40	cells	cell	NOUN
hls-12456	200	41	.	.	PUNCT
hls-12456	201	1	they	they	PRON
hls-12456	201	2	can	can	AUX
hls-12456	201	3	either	either	ADV
hls-12456	201	4	activate	activate	VERB
hls-12456	201	5	or	or	CCONJ
hls-12456	201	6	suppress	suppress	VERB
hls-12456	201	7	the	the	DET
hls-12456	201	8	growth	growth	NOUN
hls-12456	201	9	of	of	ADP
hls-12456	201	10	cell	cell	NOUN
hls-12456	201	11	populations	population	NOUN
hls-12456	201	12	.	.	PUNCT
hls-12456	202	1	mrnas	mrna	NOUN
hls-12456	202	2	also	also	ADV
hls-12456	202	3	affect	affect	VERB
hls-12456	202	4	transcription	transcription	NOUN
hls-12456	202	5	factors	factor	NOUN
hls-12456	202	6	involved	involve	VERB
hls-12456	202	7	in	in	ADP
hls-12456	202	8	the	the	DET
hls-12456	202	9	wnt	wnt	PROPN
hls-12456	202	10	pathway	pathway	NOUN
hls-12456	202	11	,	,	PUNCT
hls-12456	202	12	such	such	ADJ
hls-12456	202	13	as	as	ADP
hls-12456	202	14	β	β	NOUN
hls-12456	202	15	-	-	ADJ
hls-12456	202	16	catenin	catenin	NOUN
hls-12456	202	17	and	and	CCONJ
hls-12456	202	18	lef	lef	PROPN
hls-12456	202	19	/	/	SYM
hls-12456	202	20	tcf	tcf	PROPN
hls-12456	202	21	.	.	PUNCT
hls-12456	203	1	for	for	ADP
hls-12456	203	2	instance	instance	NOUN
hls-12456	203	3	,	,	PUNCT
hls-12456	203	4	mrna-129	mrna-129	NOUN
hls-12456	203	5	-	-	PUNCT
hls-12456	203	6	5p	5p	NUM
hls-12456	203	7	,	,	PUNCT
hls-12456	203	8	mrna-24	mrna-24	PROPN
hls-12456	203	9	,	,	PUNCT
hls-12456	203	10	and	and	CCONJ
hls-12456	203	11	mrna-132	mrna-132	ADJ
hls-12456	203	12	influence	influence	NOUN
hls-12456	203	13	these	these	DET
hls-12456	203	14	factors	factor	NOUN
hls-12456	203	15	,	,	PUNCT
hls-12456	203	16	modulating	modulate	VERB
hls-12456	203	17	cell	cell	NOUN
hls-12456	203	18	growth	growth	NOUN
hls-12456	203	19	.	.	PUNCT
hls-12456	204	1	mrnas	mrna	NOUN
hls-12456	204	2	targeting	target	VERB
hls-12456	204	3	wnt	wnt	NOUN
hls-12456	204	4	signaling	signal	VERB
hls-12456	204	5	inhibitors	inhibitor	NOUN
hls-12456	204	6	,	,	PUNCT
hls-12456	204	7	such	such	ADJ
hls-12456	204	8	as	as	ADP
hls-12456	204	9	gsk-3β	gsk-3β	PROPN
hls-12456	204	10	and	and	CCONJ
hls-12456	204	11	apc	apc	PROPN
hls-12456	204	12	,	,	PUNCT
hls-12456	204	13	regulate	regulate	VERB
hls-12456	204	14	β	β	ADJ
hls-12456	204	15	-	-	ADJ
hls-12456	204	16	catenin	catenin	ADJ
hls-12456	204	17	levels	level	NOUN
hls-12456	204	18	and	and	CCONJ
hls-12456	204	19	influence	influence	VERB
hls-12456	204	20	the	the	DET
hls-12456	204	21	development	development	NOUN
hls-12456	204	22	of	of	ADP
hls-12456	204	23	cell	cell	NOUN
hls-12456	204	24	populations	population	NOUN
hls-12456	204	25	.	.	PUNCT
hls-12456	205	1	researchers	researcher	NOUN
hls-12456	205	2	emphasized	emphasize	VERB
hls-12456	205	3	that	that	SCONJ
hls-12456	205	4	mrnas	mrna	NOUN
hls-12456	205	5	are	be	AUX
hls-12456	205	6	potential	potential	ADJ
hls-12456	205	7	targets	target	NOUN
hls-12456	205	8	for	for	ADP
hls-12456	205	9	therapeutic	therapeutic	ADJ
hls-12456	205	10	and	and	CCONJ
hls-12456	205	11	preventive	preventive	ADJ
hls-12456	205	12	interventions	intervention	NOUN
hls-12456	205	13	in	in	ADP
hls-12456	205	14	oncology	oncology	NOUN
hls-12456	205	15	.	.	PUNCT
hls-12456	206	1	this	this	DET
hls-12456	206	2	work	work	NOUN
hls-12456	206	3	expands	expand	VERB
hls-12456	206	4	the	the	DET
hls-12456	206	5	understanding	understanding	NOUN
hls-12456	206	6	of	of	ADP
hls-12456	206	7	molecular	molecular	ADJ
hls-12456	206	8	-	-	PUNCT
hls-12456	206	9	genetic	genetic	ADJ
hls-12456	206	10	mechanisms	mechanism	NOUN
hls-12456	206	11	in	in	ADP
hls-12456	206	12	oncopathology	oncopathology	NOUN
hls-12456	206	13	through	through	ADP
hls-12456	206	14	the	the	DET
hls-12456	206	15	analysis	analysis	NOUN
hls-12456	206	16	of	of	ADP
hls-12456	206	17	the	the	DET
hls-12456	206	18	role	role	NOUN
hls-12456	206	19	of	of	ADP
hls-12456	206	20	mrnas	mrna	NOUN
hls-12456	206	21	,	,	PUNCT
hls-12456	206	22	although	although	SCONJ
hls-12456	206	23	other	other	ADJ
hls-12456	206	24	aspects	aspect	NOUN
hls-12456	206	25	of	of	ADP
hls-12456	206	26	cell	cell	NOUN
hls-12456	206	27	growth	growth	NOUN
hls-12456	206	28	regulation	regulation	NOUN
hls-12456	206	29	were	be	AUX
hls-12456	206	30	not	not	PART
hls-12456	206	31	addressed	address	VERB
hls-12456	206	32	by	by	ADP
hls-12456	206	33	the	the	DET
hls-12456	206	34	authors	author	NOUN
hls-12456	206	35	.	.	PUNCT
hls-12456	207	1	in	in	ADP
hls-12456	207	2	summary	summary	NOUN
hls-12456	207	3	,	,	PUNCT
hls-12456	207	4	significant	significant	ADJ
hls-12456	207	5	advancements	advancement	NOUN
hls-12456	207	6	have	have	AUX
hls-12456	207	7	been	be	AUX
hls-12456	207	8	made	make	VERB
hls-12456	207	9	in	in	ADP
hls-12456	207	10	expanding	expand	VERB
hls-12456	207	11	existing	exist	VERB
hls-12456	207	12	knowledge	knowledge	NOUN
hls-12456	207	13	of	of	ADP
hls-12456	207	14	the	the	DET
hls-12456	207	15	molecular	molecular	ADJ
hls-12456	207	16	-	-	PUNCT
hls-12456	207	17	genetic	genetic	ADJ
hls-12456	207	18	mechanisms	mechanism	NOUN
hls-12456	207	19	underlying	underlie	VERB
hls-12456	207	20	the	the	DET
hls-12456	207	21	development	development	NOUN
hls-12456	207	22	of	of	ADP
hls-12456	207	23	malignant	malignant	ADJ
hls-12456	207	24	tumors	tumor	NOUN
hls-12456	207	25	and	and	CCONJ
hls-12456	207	26	their	their	PRON
hls-12456	207	27	metastasis	metastasis	NOUN
hls-12456	207	28	.	.	PUNCT
hls-12456	208	1	the	the	DET
hls-12456	208	2	role	role	NOUN
hls-12456	208	3	of	of	ADP
hls-12456	208	4	non	non	ADJ
hls-12456	208	5	-	-	ADJ
hls-12456	208	6	cell	cell	ADJ
hls-12456	208	7	autonomous	autonomous	ADJ
hls-12456	208	8	effectors	effector	NOUN
hls-12456	208	9	in	in	ADP
hls-12456	208	10	oncogenic	oncogenic	ADJ
hls-12456	208	11	cell	cell	NOUN
hls-12456	208	12	transformation	transformation	NOUN
hls-12456	208	13	processes	process	NOUN
hls-12456	208	14	,	,	PUNCT
hls-12456	208	15	their	their	PRON
hls-12456	208	16	interactions	interaction	NOUN
hls-12456	208	17	with	with	ADP
hls-12456	208	18	each	each	DET
hls-12456	208	19	other	other	ADJ
hls-12456	208	20	and	and	CCONJ
hls-12456	208	21	the	the	DET
hls-12456	208	22	surrounding	surround	VERB
hls-12456	208	23	environment	environment	NOUN
hls-12456	208	24	,	,	PUNCT
hls-12456	208	25	and	and	CCONJ
hls-12456	208	26	their	their	PRON
hls-12456	208	27	impact	impact	NOUN
hls-12456	208	28	on	on	ADP
hls-12456	208	29	intracellular	intracellular	ADJ
hls-12456	208	30	signaling	signal	VERB
hls-12456	208	31	pathways	pathway	NOUN
hls-12456	208	32	,	,	PUNCT
hls-12456	208	33	gene	gene	NOUN
hls-12456	208	34	expression	expression	NOUN
hls-12456	208	35	profiles	profile	NOUN
hls-12456	208	36	,	,	PUNCT
hls-12456	208	37	proliferation	proliferation	NOUN
hls-12456	208	38	,	,	PUNCT
hls-12456	208	39	differentiation	differentiation	NOUN
hls-12456	208	40	,	,	PUNCT
hls-12456	208	41	and	and	CCONJ
hls-12456	208	42	migration	migration	NOUN
hls-12456	208	43	of	of	ADP
hls-12456	208	44	tumor	tumor	NOUN
hls-12456	208	45	cells	cell	NOUN
hls-12456	208	46	have	have	AUX
hls-12456	208	47	been	be	AUX
hls-12456	208	48	thoroughly	thoroughly	ADV
hls-12456	208	49	analyzed	analyze	VERB
hls-12456	208	50	.	.	PUNCT
hls-12456	209	1	additionally	additionally	ADV
hls-12456	209	2	,	,	PUNCT
hls-12456	209	3	the	the	DET
hls-12456	209	4	study	study	NOUN
hls-12456	209	5	focused	focus	VERB
hls-12456	209	6	on	on	ADP
hls-12456	209	7	the	the	DET
hls-12456	209	8	roles	role	NOUN
hls-12456	209	9	of	of	ADP
hls-12456	209	10	lncrnas	lncrna	NOUN
hls-12456	209	11	and	and	CCONJ
hls-12456	209	12	mrnas	mrna	NOUN
hls-12456	209	13	in	in	ADP
hls-12456	209	14	oncogenesis	oncogenesis	NOUN
hls-12456	209	15	,	,	PUNCT
hls-12456	209	16	metastasis	metastasis	NOUN
hls-12456	209	17	,	,	PUNCT
hls-12456	209	18	differentiation	differentiation	NOUN
hls-12456	209	19	,	,	PUNCT
hls-12456	209	20	and	and	CCONJ
hls-12456	209	21	cell	cell	NOUN
hls-12456	209	22	growth	growth	NOUN
hls-12456	209	23	.	.	PUNCT
hls-12456	210	1	the	the	DET
hls-12456	210	2	obtained	obtain	VERB
hls-12456	210	3	results	result	NOUN
hls-12456	210	4	significantly	significantly	ADV
hls-12456	210	5	deepen	deepen	VERB
hls-12456	210	6	the	the	DET
hls-12456	210	7	understanding	understanding	NOUN
hls-12456	210	8	of	of	ADP
hls-12456	210	9	tumor	tumor	NOUN
hls-12456	210	10	biology	biology	NOUN
hls-12456	210	11	and	and	CCONJ
hls-12456	210	12	open	open	VERB
hls-12456	210	13	new	new	ADJ
hls-12456	210	14	therapeutic	therapeutic	ADJ
hls-12456	210	15	strategies	strategy	NOUN
hls-12456	210	16	for	for	ADP
hls-12456	210	17	combating	combat	VERB
hls-12456	210	18	cancer	cancer	NOUN
hls-12456	210	19	.	.	PUNCT
hls-12456	211	1	conclusions	conclusion	NOUN
hls-12456	211	2	morphometric	morphometric	ADJ
hls-12456	211	3	and	and	CCONJ
hls-12456	211	4	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	211	5	analysis	analysis	NOUN
hls-12456	211	6	of	of	ADP
hls-12456	211	7	primary	primary	ADJ
hls-12456	211	8	cancer	cancer	NOUN
hls-12456	211	9	cells	cell	NOUN
hls-12456	211	10	and	and	CCONJ
hls-12456	211	11	their	their	PRON
hls-12456	211	12	metastases	metastasis	NOUN
hls-12456	211	13	from	from	ADP
hls-12456	211	14	different	different	ADJ
hls-12456	211	15	locations	location	NOUN
hls-12456	211	16	showed	show	VERB
hls-12456	211	17	wide	wide	ADJ
hls-12456	211	18	variability	variability	NOUN
hls-12456	211	19	in	in	ADP
hls-12456	211	20	the	the	DET
hls-12456	211	21	content	content	NOUN
hls-12456	211	22	of	of	ADP
hls-12456	211	23	dna	dna	PROPN
hls-12456	211	24	,	,	PUNCT
hls-12456	211	25	nuclear	nuclear	ADJ
hls-12456	211	26	,	,	PUNCT
hls-12456	211	27	and	and	CCONJ
hls-12456	211	28	cytoplasmic	cytoplasmic	ADJ
hls-12456	211	29	rna	rna	PROPN
hls-12456	211	30	.	.	PUNCT
hls-12456	212	1	pronounced	pronounce	VERB
hls-12456	212	2	heterogeneity	heterogeneity	NOUN
hls-12456	212	3	of	of	ADP
hls-12456	212	4	dna	dna	PROPN
hls-12456	212	5	content	content	NOUN
hls-12456	212	6	in	in	ADP
hls-12456	212	7	different	different	ADJ
hls-12456	212	8	metastases	metastasis	NOUN
hls-12456	212	9	,	,	PUNCT
hls-12456	212	10	as	as	ADV
hls-12456	212	11	well	well	ADV
hls-12456	212	12	as	as	ADP
hls-12456	212	13	inconsistency	inconsistency	NOUN
hls-12456	212	14	in	in	ADP
hls-12456	212	15	changes	change	NOUN
hls-12456	212	16	in	in	ADP
hls-12456	212	17	the	the	DET
hls-12456	212	18	concentration	concentration	NOUN
hls-12456	212	19	of	of	ADP
hls-12456	212	20	dna	dna	NOUN
hls-12456	212	21	and	and	CCONJ
hls-12456	212	22	rna	rna	NOUN
hls-12456	212	23	in	in	ADP
hls-12456	212	24	the	the	DET
hls-12456	212	25	cells	cell	NOUN
hls-12456	212	26	of	of	ADP
hls-12456	212	27	individual	individual	ADJ
hls-12456	212	28	metastases	metastasis	NOUN
hls-12456	212	29	,	,	PUNCT
hls-12456	212	30	were	be	AUX
hls-12456	212	31	established	establish	VERB
hls-12456	212	32	.	.	PUNCT
hls-12456	213	1	since	since	SCONJ
hls-12456	213	2	metastases	metastasis	NOUN
hls-12456	213	3	are	be	AUX
hls-12456	213	4	dominated	dominate	VERB
hls-12456	213	5	by	by	ADP
hls-12456	213	6	cells	cell	NOUN
hls-12456	213	7	with	with	ADP
hls-12456	213	8	a	a	DET
hls-12456	213	9	lower	low	ADJ
hls-12456	213	10	level	level	NOUN
hls-12456	213	11	of	of	ADP
hls-12456	213	12	differentiation	differentiation	NOUN
hls-12456	213	13	and	and	CCONJ
hls-12456	213	14	a	a	DET
hls-12456	213	15	higher	high	ADJ
hls-12456	213	16	degree	degree	NOUN
hls-12456	213	17	of	of	ADP
hls-12456	213	18	heteroand	heteroand	NOUN
hls-12456	213	19	polyploidy	polyploidy	NOUN
hls-12456	213	20	,	,	PUNCT
hls-12456	213	21	and	and	CCONJ
hls-12456	213	22	individual	individual	ADJ
hls-12456	213	23	metastases	metastasis	NOUN
hls-12456	213	24	often	often	ADV
hls-12456	213	25	have	have	VERB
hls-12456	213	26	unique	unique	ADJ
hls-12456	213	27	characteristics	characteristic	NOUN
hls-12456	213	28	based	base	VERB
hls-12456	213	29	on	on	ADP
hls-12456	213	30	these	these	DET
hls-12456	213	31	indicators	indicator	NOUN
hls-12456	213	32	,	,	PUNCT
hls-12456	213	33	it	it	PRON
hls-12456	213	34	is	be	AUX
hls-12456	213	35	worth	worth	ADJ
hls-12456	213	36	concluding	conclude	VERB
hls-12456	213	37	about	about	ADP
hls-12456	213	38	the	the	DET
hls-12456	213	39	selection	selection	NOUN
hls-12456	213	40	of	of	ADP
hls-12456	213	41	highly	highly	ADV
hls-12456	213	42	metastatic	metastatic	ADJ
hls-12456	213	43	clones	clone	NOUN
hls-12456	213	44	of	of	ADP
hls-12456	213	45	cells	cell	NOUN
hls-12456	213	46	that	that	PRON
hls-12456	213	47	are	be	AUX
hls-12456	213	48	less	less	ADV
hls-12456	213	49	differentiated	differentiated	ADJ
hls-12456	213	50	than	than	ADP
hls-12456	213	51	the	the	DET
hls-12456	213	52	bulk	bulk	NOUN
hls-12456	213	53	of	of	ADP
hls-12456	213	54	cells	cell	NOUN
hls-12456	213	55	of	of	ADP
hls-12456	213	56	the	the	DET
hls-12456	213	57	primary	primary	ADJ
hls-12456	213	58	tumor	tumor	NOUN
hls-12456	213	59	focus	focus	NOUN
hls-12456	213	60	.	.	PUNCT
hls-12456	214	1	this	this	PRON
hls-12456	214	2	emphasizes	emphasize	VERB
hls-12456	214	3	the	the	DET
hls-12456	214	4	complexity	complexity	NOUN
hls-12456	214	5	and	and	CCONJ
hls-12456	214	6	dynamics	dynamic	NOUN
hls-12456	214	7	of	of	ADP
hls-12456	214	8	the	the	DET
hls-12456	214	9	process	process	NOUN
hls-12456	214	10	of	of	ADP
hls-12456	214	11	cancer	cancer	NOUN
hls-12456	214	12	occurrence	occurrence	NOUN
hls-12456	214	13	,	,	PUNCT
hls-12456	214	14	development	development	NOUN
hls-12456	214	15	,	,	PUNCT
hls-12456	214	16	and	and	CCONJ
hls-12456	214	17	spread	spread	VERB
hls-12456	214	18	,	,	PUNCT
hls-12456	214	19	as	as	ADV
hls-12456	214	20	well	well	ADV
hls-12456	214	21	as	as	ADP
hls-12456	214	22	the	the	DET
hls-12456	214	23	importance	importance	NOUN
hls-12456	214	24	of	of	ADP
hls-12456	214	25	understanding	understand	VERB
hls-12456	214	26	the	the	DET
hls-12456	214	27	molecular	molecular	ADJ
hls-12456	214	28	and	and	CCONJ
hls-12456	214	29	cellular	cellular	ADJ
hls-12456	214	30	changes	change	NOUN
hls-12456	214	31	that	that	PRON
hls-12456	214	32	occur	occur	VERB
hls-12456	214	33	during	during	ADP
hls-12456	214	34	these	these	DET
hls-12456	214	35	processes	process	NOUN
hls-12456	214	36	and	and	CCONJ
hls-12456	214	37	their	their	PRON
hls-12456	214	38	potential	potential	NOUN
hls-12456	214	39	for	for	ADP
hls-12456	214	40	developing	develop	VERB
hls-12456	214	41	effective	effective	ADJ
hls-12456	214	42	strategies	strategy	NOUN
hls-12456	214	43	for	for	ADP
hls-12456	214	44	the	the	DET
hls-12456	214	45	diagnosis	diagnosis	NOUN
hls-12456	214	46	,	,	PUNCT
hls-12456	214	47	treatment	treatment	NOUN
hls-12456	214	48	,	,	PUNCT
hls-12456	214	49	and	and	CCONJ
hls-12456	214	50	prevention	prevention	NOUN
hls-12456	214	51	of	of	ADP
hls-12456	214	52	oncological	oncological	ADJ
hls-12456	214	53	pathology	pathology	NOUN
hls-12456	214	54	.	.	PUNCT
hls-12456	215	1	thus	thus	ADV
hls-12456	215	2	,	,	PUNCT
hls-12456	215	3	an	an	DET
hls-12456	215	4	in	in	ADP
hls-12456	215	5	-	-	PUNCT
hls-12456	215	6	depth	depth	NOUN
hls-12456	215	7	analysis	analysis	NOUN
hls-12456	215	8	of	of	ADP
hls-12456	215	9	metastatic	metastatic	ADJ
hls-12456	215	10	cell	cell	NOUN
hls-12456	215	11	populations	population	NOUN
hls-12456	215	12	in	in	ADP
hls-12456	215	13	comparison	comparison	NOUN
hls-12456	215	14	with	with	ADP
hls-12456	215	15	cells	cell	NOUN
hls-12456	215	16	of	of	ADP
hls-12456	215	17	the	the	DET
hls-12456	215	18	primary	primary	ADJ
hls-12456	215	19	tumor	tumor	NOUN
hls-12456	215	20	center	center	NOUN
hls-12456	215	21	revealed	reveal	VERB
hls-12456	215	22	that	that	SCONJ
hls-12456	215	23	in	in	ADP
hls-12456	215	24	metastases	metastasis	NOUN
hls-12456	215	25	,	,	PUNCT
hls-12456	215	26	an	an	DET
hls-12456	215	27	increase	increase	NOUN
hls-12456	215	28	in	in	ADP
hls-12456	215	29	the	the	DET
hls-12456	215	30	size	size	NOUN
hls-12456	215	31	of	of	ADP
hls-12456	215	32	cell	cell	NOUN
hls-12456	215	33	nuclei	nucleus	NOUN
hls-12456	215	34	,	,	PUNCT
hls-12456	215	35	a	a	DET
hls-12456	215	36	decrease	decrease	NOUN
hls-12456	215	37	in	in	ADP
hls-12456	215	38	dna	dna	PROPN
hls-12456	215	39	concentration	concentration	NOUN
hls-12456	215	40	,	,	PUNCT
hls-12456	215	41	and	and	CCONJ
hls-12456	215	42	an	an	DET
hls-12456	215	43	increase	increase	NOUN
hls-12456	215	44	in	in	ADP
hls-12456	215	45	dnaai	dnaai	PROPN
hls-12456	215	46	are	be	AUX
hls-12456	215	47	more	more	ADV
hls-12456	215	48	often	often	ADV
hls-12456	215	49	observed	observe	VERB
hls-12456	215	50	;	;	PUNCT
hls-12456	215	51	there	there	PRON
hls-12456	215	52	is	be	VERB
hls-12456	215	53	also	also	ADV
hls-12456	215	54	a	a	DET
hls-12456	215	55	decrease	decrease	NOUN
hls-12456	215	56	in	in	ADP
hls-12456	215	57	the	the	DET
hls-12456	215	58	concentration	concentration	NOUN
hls-12456	215	59	of	of	ADP
hls-12456	215	60	rna	rna	NOUN
hls-12456	215	61	in	in	ADP
hls-12456	215	62	both	both	CCONJ
hls-12456	215	63	the	the	DET
hls-12456	215	64	cytoplasm	cytoplasm	NOUN
hls-12456	215	65	and	and	CCONJ
hls-12456	215	66	the	the	DET
hls-12456	215	67	nucleus	nucleus	NOUN
hls-12456	215	68	.	.	PUNCT
hls-12456	216	1	these	these	DET
hls-12456	216	2	observations	observation	NOUN
hls-12456	216	3	may	may	AUX
hls-12456	216	4	indicate	indicate	VERB
hls-12456	216	5	a	a	DET
hls-12456	216	6	tendency	tendency	NOUN
hls-12456	216	7	towards	towards	ADP
hls-12456	216	8	an	an	DET
hls-12456	216	9	increase	increase	NOUN
hls-12456	216	10	in	in	ADP
hls-12456	216	11	the	the	DET
hls-12456	216	12	number	number	NOUN
hls-12456	216	13	of	of	ADP
hls-12456	216	14	less	less	ADV
hls-12456	216	15	differentiated	differentiated	ADJ
hls-12456	216	16	cell	cell	NOUN
hls-12456	216	17	clones	clone	NOUN
hls-12456	216	18	in	in	ADP
hls-12456	216	19	the	the	DET
hls-12456	216	20	process	process	NOUN
hls-12456	216	21	of	of	ADP
hls-12456	216	22	metastasis	metastasis	NOUN
hls-12456	216	23	compared	compare	VERB
hls-12456	216	24	to	to	ADP
hls-12456	216	25	the	the	DET
hls-12456	216	26	primary	primary	ADJ
hls-12456	216	27	tumor	tumor	NOUN
hls-12456	216	28	focus	focus	NOUN
hls-12456	216	29	.	.	PUNCT
hls-12456	217	1	adding	add	VERB
hls-12456	217	2	to	to	ADP
hls-12456	217	3	this	this	DET
hls-12456	217	4	awareness	awareness	NOUN
hls-12456	217	5	of	of	ADP
hls-12456	217	6	the	the	DET
hls-12456	217	7	importance	importance	NOUN
hls-12456	217	8	of	of	ADP
hls-12456	217	9	non	non	ADJ
hls-12456	217	10	-	-	ADJ
hls-12456	217	11	cellautonomous	cellautonomous	ADJ
hls-12456	217	12	effectors	effector	NOUN
hls-12456	217	13	in	in	ADP
hls-12456	217	14	the	the	DET
hls-12456	217	15	process	process	NOUN
hls-12456	217	16	of	of	ADP
hls-12456	217	17	oncogenesis	oncogenesis	NOUN
hls-12456	217	18	and	and	CCONJ
hls-12456	217	19	metastasis	metastasis	NOUN
hls-12456	217	20	,	,	PUNCT
hls-12456	217	21	it	it	PRON
hls-12456	217	22	is	be	AUX
hls-12456	217	23	possible	possible	ADJ
hls-12456	217	24	to	to	PART
hls-12456	217	25	gain	gain	VERB
hls-12456	217	26	a	a	DET
hls-12456	217	27	more	more	ADV
hls-12456	217	28	profound	profound	ADJ
hls-12456	217	29	understanding	understanding	NOUN
hls-12456	217	30	of	of	ADP
hls-12456	217	31	the	the	DET
hls-12456	217	32	interaction	interaction	NOUN
hls-12456	217	33	between	between	ADP
hls-12456	217	34	tumor	tumor	NOUN
hls-12456	217	35	cells	cell	NOUN
hls-12456	217	36	and	and	CCONJ
hls-12456	217	37	their	their	PRON
hls-12456	217	38	microenvironment	microenvironment	NOUN
hls-12456	217	39	.	.	PUNCT
hls-12456	218	1	thus	thus	ADV
hls-12456	218	2	,	,	PUNCT
hls-12456	218	3	immune	immune	ADJ
hls-12456	218	4	cells	cell	NOUN
hls-12456	218	5	,	,	PUNCT
hls-12456	218	6	fibroblasts	fibroblast	NOUN
hls-12456	218	7	,	,	PUNCT
hls-12456	218	8	endothelial	endothelial	ADJ
hls-12456	218	9	cells	cell	NOUN
hls-12456	218	10	,	,	PUNCT
hls-12456	218	11	as	as	ADV
hls-12456	218	12	well	well	ADV
hls-12456	218	13	as	as	ADP
hls-12456	218	14	the	the	DET
hls-12456	218	15	extracellular	extracellular	ADJ
hls-12456	218	16	matrix	matrix	NOUN
hls-12456	218	17	and	and	CCONJ
hls-12456	218	18	molecules	molecule	NOUN
hls-12456	218	19	secreted	secrete	VERB
hls-12456	218	20	by	by	ADP
hls-12456	218	21	these	these	DET
hls-12456	218	22	cells	cell	NOUN
hls-12456	218	23	have	have	VERB
hls-12456	218	24	,	,	PUNCT
hls-12456	218	25	a	a	DET
hls-12456	218	26	significant	significant	ADJ
hls-12456	218	27	impact	impact	NOUN
hls-12456	218	28	on	on	ADP
hls-12456	218	29	the	the	DET
hls-12456	218	30	development	development	NOUN
hls-12456	218	31	and	and	CCONJ
hls-12456	218	32	progression	progression	NOUN
hls-12456	218	33	of	of	ADP
hls-12456	218	34	cancer	cancer	NOUN
hls-12456	218	35	.	.	PUNCT
hls-12456	219	1	understanding	understand	VERB
hls-12456	219	2	these	these	DET
hls-12456	219	3	interactions	interaction	NOUN
hls-12456	219	4	may	may	AUX
hls-12456	219	5	open	open	VERB
hls-12456	219	6	up	up	ADP
hls-12456	219	7	new	new	ADJ
hls-12456	219	8	opportunities	opportunity	NOUN
hls-12456	219	9	for	for	ADP
hls-12456	219	10	oncology	oncology	NOUN
hls-12456	219	11	therapy	therapy	NOUN
hls-12456	219	12	targeting	target	VERB
hls-12456	219	13	not	not	PART
hls-12456	219	14	only	only	ADV
hls-12456	219	15	tumor	tumor	NOUN
hls-12456	219	16	cells	cell	NOUN
hls-12456	219	17	but	but	CCONJ
hls-12456	219	18	also	also	ADV
hls-12456	219	19	their	their	PRON
hls-12456	219	20	interactions	interaction	NOUN
hls-12456	219	21	with	with	ADP
hls-12456	219	22	the	the	DET
hls-12456	219	23	microenvironment	microenvironment	NOUN
hls-12456	219	24	.	.	PUNCT
hls-12456	220	1	therefore	therefore	ADV
hls-12456	220	2	,	,	PUNCT
hls-12456	220	3	the	the	DET
hls-12456	220	4	results	result	NOUN
hls-12456	220	5	of	of	ADP
hls-12456	220	6	this	this	DET
hls-12456	220	7	study	study	NOUN
hls-12456	220	8	,	,	PUNCT
hls-12456	220	9	which	which	PRON
hls-12456	220	10	encompass	encompass	VERB
hls-12456	220	11	the	the	DET
hls-12456	220	12	analysis	analysis	NOUN
hls-12456	220	13	of	of	ADP
hls-12456	220	14	dna	dna	PROPN
hls-12456	220	15	and	and	CCONJ
hls-12456	220	16	rna	rna	NOUN
hls-12456	220	17	levels	level	NOUN
hls-12456	220	18	in	in	ADP
hls-12456	220	19	primary	primary	ADJ
hls-12456	220	20	and	and	CCONJ
hls-12456	220	21	metastatic	metastatic	ADJ
hls-12456	220	22	tumor	tumor	NOUN
hls-12456	220	23	cells	cell	NOUN
hls-12456	220	24	,	,	PUNCT
hls-12456	220	25	indicate	indicate	VERB
hls-12456	220	26	a	a	DET
hls-12456	220	27	complex	complex	ADJ
hls-12456	220	28	interplay	interplay	NOUN
hls-12456	220	29	between	between	ADP
hls-12456	220	30	different	different	ADJ
hls-12456	220	31	types	type	NOUN
hls-12456	220	32	of	of	ADP
hls-12456	220	33	nucleic	nucleic	ADJ
hls-12456	220	34	acids	acid	NOUN
hls-12456	220	35	,	,	PUNCT
hls-12456	220	36	revealing	reveal	VERB
hls-12456	220	37	substantial	substantial	ADJ
hls-12456	220	38	heterogeneity	heterogeneity	NOUN
hls-12456	220	39	in	in	ADP
hls-12456	220	40	the	the	DET
hls-12456	220	41	molecular	molecular	ADJ
hls-12456	220	42	mechanisms	mechanism	NOUN
hls-12456	220	43	regulating	regulate	VERB
hls-12456	220	44	cancer	cancer	NOUN
hls-12456	220	45	growth	growth	NOUN
hls-12456	220	46	and	and	CCONJ
hls-12456	220	47	progression	progression	NOUN
hls-12456	220	48	,	,	PUNCT
hls-12456	220	49	while	while	SCONJ
hls-12456	220	50	highlighting	highlight	VERB
hls-12456	220	51	the	the	DET
hls-12456	220	52	importance	importance	NOUN
hls-12456	220	53	of	of	ADP
hls-12456	220	54	additional	additional	ADJ
hls-12456	220	55	studies	study	NOUN
hls-12456	220	56	in	in	ADP
hls-12456	220	57	this	this	DET
hls-12456	220	58	area	area	NOUN
hls-12456	220	59	,	,	PUNCT
hls-12456	220	60	especially	especially	ADV
hls-12456	220	61	considering	consider	VERB
hls-12456	220	62	the	the	DET
hls-12456	220	63	role	role	NOUN
hls-12456	220	64	of	of	ADP
hls-12456	220	65	non	non	ADJ
hls-12456	220	66	-	-	ADJ
hls-12456	220	67	cell	cell	ADJ
hls-12456	220	68	autonomous	autonomous	ADJ
hls-12456	220	69	effectors	effector	NOUN
hls-12456	220	70	and	and	CCONJ
hls-12456	220	71	mrna	mrna	NOUN
hls-12456	220	72	in	in	ADP
hls-12456	220	73	these	these	DET
hls-12456	220	74	processes	process	NOUN
hls-12456	220	75	.	.	PUNCT
hls-12456	221	1	it	it	PRON
hls-12456	221	2	is	be	AUX
hls-12456	221	3	important	important	ADJ
hls-12456	221	4	to	to	PART
hls-12456	221	5	acknowledge	acknowledge	VERB
hls-12456	221	6	several	several	ADJ
hls-12456	221	7	potential	potential	ADJ
hls-12456	221	8	limitations	limitation	NOUN
hls-12456	221	9	.	.	PUNCT
hls-12456	222	1	first	first	ADV
hls-12456	222	2	off	off	ADV
hls-12456	222	3	,	,	PUNCT
hls-12456	222	4	even	even	ADV
hls-12456	222	5	with	with	ADP
hls-12456	222	6	a	a	DET
hls-12456	222	7	reasonable	reasonable	ADJ
hls-12456	222	8	sample	sample	NOUN
hls-12456	222	9	size	size	NOUN
hls-12456	222	10	,	,	PUNCT
hls-12456	222	11	the	the	DET
hls-12456	222	12	results	result	NOUN
hls-12456	222	13	could	could	AUX
hls-12456	222	14	not	not	PART
hls-12456	222	15	be	be	AUX
hls-12456	222	16	as	as	ADV
hls-12456	222	17	broadly	broadly	ADV
hls-12456	222	18	applicable	applicable	ADJ
hls-12456	222	19	as	as	SCONJ
hls-12456	222	20	they	they	PRON
hls-12456	222	21	could	could	AUX
hls-12456	222	22	be	be	AUX
hls-12456	222	23	,	,	PUNCT
hls-12456	222	24	especially	especially	ADV
hls-12456	222	25	for	for	ADP
hls-12456	222	26	less	less	ADV
hls-12456	222	27	common	common	ADJ
hls-12456	222	28	tumor	tumor	NOUN
hls-12456	222	29	types	type	NOUN
hls-12456	222	30	or	or	CCONJ
hls-12456	222	31	subtypes	subtype	NOUN
hls-12456	222	32	.	.	PUNCT
hls-12456	223	1	furthermore	furthermore	ADV
hls-12456	223	2	,	,	PUNCT
hls-12456	223	3	because	because	SCONJ
hls-12456	223	4	the	the	DET
hls-12456	223	5	analysis	analysis	NOUN
hls-12456	223	6	is	be	AUX
hls-12456	223	7	retrospective	retrospective	ADJ
hls-12456	223	8	in	in	ADP
hls-12456	223	9	nature	nature	NOUN
hls-12456	223	10	,	,	PUNCT
hls-12456	223	11	a	a	DET
hls-12456	223	12	longer	long	ADJ
hls-12456	223	13	time	time	NOUN
hls-12456	223	14	span	span	NOUN
hls-12456	223	15	was	be	AUX
hls-12456	223	16	used	use	VERB
hls-12456	223	17	to	to	PART
hls-12456	223	18	gather	gather	VERB
hls-12456	223	19	the	the	DET
hls-12456	223	20	samples	sample	NOUN
hls-12456	223	21	,	,	PUNCT
hls-12456	223	22	which	which	PRON
hls-12456	223	23	may	may	AUX
hls-12456	223	24	increase	increase	VERB
hls-12456	223	25	variability	variability	NOUN
hls-12456	223	26	over	over	ADP
hls-12456	223	27	time	time	NOUN
hls-12456	223	28	due	due	ADP
hls-12456	223	29	to	to	ADP
hls-12456	223	30	adjustments	adjustment	NOUN
hls-12456	223	31	made	make	VERB
hls-12456	223	32	to	to	PART
hls-12456	223	33	sample	sample	VERB
hls-12456	223	34	processing	processing	NOUN
hls-12456	223	35	or	or	CCONJ
hls-12456	223	36	measurement	measurement	NOUN
hls-12456	223	37	methods	method	NOUN
hls-12456	223	38	.	.	PUNCT
hls-12456	224	1	additionally	additionally	ADV
hls-12456	224	2	,	,	PUNCT
hls-12456	224	3	the	the	DET
hls-12456	224	4	study	study	NOUN
hls-12456	224	5	only	only	ADV
hls-12456	224	6	used	use	VERB
hls-12456	224	7	microspectrophotometric	microspectrophotometric	ADJ
hls-12456	224	8	analysis	analysis	NOUN
hls-12456	224	9	of	of	ADP
hls-12456	224	10	nucleic	nucleic	ADJ
hls-12456	224	11	acid	acid	NOUN
hls-12456	224	12	content	content	NOUN
hls-12456	224	13	;	;	PUNCT
hls-12456	224	14	it	it	PRON
hls-12456	224	15	did	do	AUX
hls-12456	224	16	not	not	PART
hls-12456	224	17	use	use	VERB
hls-12456	224	18	other	other	ADJ
hls-12456	224	19	molecular	molecular	ADJ
hls-12456	224	20	profiling	profiling	NOUN
hls-12456	224	21	techniques	technique	NOUN
hls-12456	224	22	,	,	PUNCT
hls-12456	224	23	such	such	ADJ
hls-12456	224	24	as	as	ADP
hls-12456	224	25	sequencing	sequence	VERB
hls-12456	224	26	or	or	CCONJ
hls-12456	224	27	gene	gene	NOUN
hls-12456	224	28	expression	expression	NOUN
hls-12456	224	29	analysis	analysis	NOUN
hls-12456	224	30	,	,	PUNCT
hls-12456	224	31	which	which	PRON
hls-12456	224	32	could	could	AUX
hls-12456	224	33	have	have	AUX
hls-12456	224	34	given	give	VERB
hls-12456	224	35	researchers	researcher	NOUN
hls-12456	224	36	a	a	DET
hls-12456	224	37	more	more	ADV
hls-12456	224	38	thorough	thorough	ADJ
hls-12456	224	39	understanding	understanding	NOUN
hls-12456	224	40	of	of	ADP
hls-12456	224	41	the	the	DET
hls-12456	224	42	underlying	underlie	VERB
hls-12456	224	43	transcriptomic	transcriptomic	ADJ
hls-12456	224	44	and	and	CCONJ
hls-12456	224	45	genomic	genomic	ADJ
hls-12456	224	46	changes	change	NOUN
hls-12456	224	47	.	.	PUNCT
hls-12456	225	1	as	as	ADP
hls-12456	225	2	for	for	ADP
hls-12456	225	3	the	the	DET
hls-12456	225	4	direction	direction	NOUN
hls-12456	225	5	of	of	ADP
hls-12456	225	6	future	future	ADJ
hls-12456	225	7	research	research	NOUN
hls-12456	225	8	,	,	PUNCT
hls-12456	225	9	it	it	PRON
hls-12456	225	10	is	be	AUX
hls-12456	225	11	important	important	ADJ
hls-12456	225	12	to	to	PART
hls-12456	225	13	focus	focus	VERB
hls-12456	225	14	further	further	ADJ
hls-12456	225	15	efforts	effort	NOUN
hls-12456	225	16	on	on	ADP
hls-12456	225	17	expanding	expand	VERB
hls-12456	225	18	the	the	DET
hls-12456	225	19	understanding	understanding	NOUN
hls-12456	225	20	of	of	ADP
hls-12456	225	21	the	the	DET
hls-12456	225	22	role	role	NOUN
hls-12456	225	23	of	of	ADP
hls-12456	225	24	mrna	mrna	PROPN
hls-12456	225	25	in	in	ADP
hls-12456	225	26	the	the	DET
hls-12456	225	27	processes	process	NOUN
hls-12456	225	28	of	of	ADP
hls-12456	225	29	tumor	tumor	NOUN
hls-12456	225	30	growth	growth	NOUN
hls-12456	225	31	and	and	CCONJ
hls-12456	225	32	development	development	NOUN
hls-12456	225	33	.	.	PUNCT
hls-12456	226	1	special	special	ADJ
hls-12456	226	2	attention	attention	NOUN
hls-12456	226	3	should	should	AUX
hls-12456	226	4	be	be	AUX
hls-12456	226	5	paid	pay	VERB
hls-12456	226	6	to	to	ADP
hls-12456	226	7	researching	research	VERB
hls-12456	226	8	the	the	DET
hls-12456	226	9	mechanisms	mechanism	NOUN
hls-12456	226	10	of	of	ADP
hls-12456	226	11	interaction	interaction	NOUN
hls-12456	226	12	between	between	ADP
hls-12456	226	13	tumor	tumor	NOUN
hls-12456	226	14	cells	cell	NOUN
hls-12456	226	15	and	and	CCONJ
hls-12456	226	16	their	their	PRON
hls-12456	226	17	microenvironment	microenvironment	NOUN
hls-12456	226	18	,	,	PUNCT
hls-12456	226	19	in	in	ADP
hls-12456	226	20	particular	particular	ADJ
hls-12456	226	21	,	,	PUNCT
hls-12456	226	22	the	the	DET
hls-12456	226	23	role	role	NOUN
hls-12456	226	24	of	of	ADP
hls-12456	226	25	the	the	DET
hls-12456	226	26	immune	immune	ADJ
hls-12456	226	27	system	system	NOUN
hls-12456	226	28	and	and	CCONJ
hls-12456	226	29	metabolic	metabolic	NOUN
hls-12456	226	30	changes	change	NOUN
hls-12456	226	31	in	in	ADP
hls-12456	226	32	these	these	DET
hls-12456	226	33	processes	process	NOUN
hls-12456	226	34	.	.	PUNCT
hls-12456	227	1	an	an	DET
hls-12456	227	2	important	important	ADJ
hls-12456	227	3	direction	direction	NOUN
hls-12456	227	4	is	be	AUX
hls-12456	227	5	also	also	ADV
hls-12456	227	6	the	the	DET
hls-12456	227	7	search	search	NOUN
hls-12456	227	8	for	for	ADP
hls-12456	227	9	new	new	ADJ
hls-12456	227	10	biomarkers	biomarker	NOUN
hls-12456	227	11	for	for	ADP
hls-12456	227	12	early	early	ADJ
hls-12456	227	13	diagnosis	diagnosis	NOUN
hls-12456	227	14	of	of	ADP
hls-12456	227	15	cancer	cancer	NOUN
hls-12456	227	16	and	and	CCONJ
hls-12456	227	17	monitoring	monitor	VERB
hls-12456	227	18	the	the	DET
hls-12456	227	19	effectiveness	effectiveness	NOUN
hls-12456	227	20	of	of	ADP
hls-12456	227	21	treatment	treatment	NOUN
hls-12456	227	22	,	,	PUNCT
hls-12456	227	23	in	in	ADP
hls-12456	227	24	particular	particular	ADJ
hls-12456	227	25	the	the	DET
hls-12456	227	26	use	use	NOUN
hls-12456	227	27	of	of	ADP
hls-12456	227	28	dncrna	dncrna	NOUN
hls-12456	227	29	and	and	CCONJ
hls-12456	227	30	snp	snp	NOUN
hls-12456	227	31	as	as	ADP
hls-12456	227	32	potential	potential	ADJ
hls-12456	227	33	targets	target	NOUN
hls-12456	227	34	for	for	ADP
hls-12456	227	35	therapy	therapy	NOUN
hls-12456	227	36	.	.	PUNCT
hls-12456	228	1	references	reference	NOUN
hls-12456	228	2	1	1	NUM
hls-12456	228	3	.	.	PUNCT
hls-12456	228	4	sulaieva	sulaieva	NOUN
hls-12456	228	5	on	on	ADP
hls-12456	228	6	,	,	PUNCT
hls-12456	228	7	artamonova	artamonova	PROPN
hls-12456	228	8	o	o	NOUN
hls-12456	228	9	,	,	PUNCT
hls-12456	228	10	dudin	dudin	VERB
hls-12456	228	11	o	o	NOUN
hls-12456	228	12	,	,	PUNCT
hls-12456	228	13	et	et	PROPN
hls-12456	228	14	al	al	PROPN
hls-12456	228	15	.	.	PUNCT
hls-12456	229	1	ethical	ethical	ADJ
hls-12456	229	2	navigation	navigation	NOUN
hls-12456	229	3	of	of	ADP
hls-12456	229	4	biobanking	biobanke	VERB
hls-12456	229	5	establishment	establishment	NOUN
hls-12456	229	6	in	in	ADP
hls-12456	229	7	ukraine	ukraine	NOUN
hls-12456	229	8	:	:	PUNCT
hls-12456	229	9	learning	learn	VERB
hls-12456	229	10	from	from	ADP
hls-12456	229	11	the	the	DET
hls-12456	229	12	experience	experience	NOUN
hls-12456	229	13	of	of	ADP
hls-12456	229	14	developing	develop	VERB
hls-12456	229	15	countries	country	NOUN
hls-12456	229	16	.	.	PUNCT
hls-12456	230	1	2023	2023	NUM
hls-12456	230	2	.	.	PUNCT
hls-12456	231	1	available	available	ADJ
hls-12456	231	2	from	from	ADP
hls-12456	231	3	:	:	PUNCT
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hls-12456	231	5	2	2	NUM
hls-12456	231	6	.	.	PUNCT
hls-12456	232	1	bondarenko	bondarenko	PROPN
hls-12456	232	2	lb	lb	NOUN
hls-12456	232	3	,	,	PUNCT
hls-12456	232	4	karatsuba	karatsuba	PROPN
hls-12456	232	5	ta	ta	PROPN
hls-12456	232	6	,	,	PUNCT
hls-12456	232	7	khavich	khavich	PRON
hls-12456	232	8	oo	oo	PROPN
hls-12456	232	9	,	,	PUNCT
hls-12456	232	10	et	et	PROPN
hls-12456	232	11	al	al	PROPN
hls-12456	232	12	.	.	PUNCT
hls-12456	233	1	the	the	DET
hls-12456	233	2	effect	effect	NOUN
hls-12456	233	3	of	of	ADP
hls-12456	233	4	ethyl	ethyl	PROPN
hls-12456	233	5	2-(quinazolin-4	2-(quinazolin-4	PROPN
hls-12456	233	6	-	-	PUNCT
hls-12456	233	7	yl	yl	NOUN
hls-12456	233	8	-	-	PUNCT
hls-12456	233	9	amino)-4,5,6,7	amino)-4,5,6,7	NOUN
hls-12456	233	10	-	-	PUNCT
hls-12456	233	11	tetrahydrobenzo	tetrahydrobenzo	NOUN
hls-12456	233	12	[	[	X
hls-12456	233	13	b]thiophene-3	b]thiophene-3	NOUN
hls-12456	233	14	-	-	PUNCT
hls-12456	233	15	carboxylate	carboxylate	NOUN
hls-12456	233	16	hydrochloride	hydrochloride	NOUN
hls-12456	233	17	on	on	ADP
hls-12456	233	18	dna	dna	PROPN
hls-12456	233	19	,	,	PUNCT
hls-12456	233	20	rna	rna	NOUN
hls-12456	233	21	,	,	PUNCT
hls-12456	233	22	chromatin	chromatin	NOUN
hls-12456	233	23	proteins	protein	NOUN
hls-12456	233	24	and	and	CCONJ
hls-12456	233	25	contents	content	NOUN
hls-12456	233	26	of	of	ADP
hls-12456	233	27	non	non	ADJ
hls-12456	233	28	-	-	NOUN
hls-12456	233	29	protein	protein	NOUN
hls-12456	233	30	and	and	CCONJ
hls-12456	233	31	proteinbounded	proteinbounde	VERB
hls-12456	233	32	sh	sh	NOUN
hls-12456	233	33	-	-	PUNCT
hls-12456	233	34	groups	group	NOUN
hls-12456	233	35	in	in	ADP
hls-12456	233	36	rats	rat	NOUN
hls-12456	233	37	’	'	PUNCT
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hls-12456	233	39	45	45	NUM
hls-12456	233	40	and	and	CCONJ
hls-12456	233	41	unchanged	unchanged	ADJ
hls-12456	233	42	skin	skin	NOUN
hls-12456	233	43	tissues	tissue	NOUN
hls-12456	233	44	.	.	PUNCT
hls-12456	234	1	pharmacol	pharmacol	NOUN
hls-12456	234	2	drug	drug	NOUN
hls-12456	234	3	toxicol	toxicol	PROPN
hls-12456	234	4	2020;14:97	2020;14:97	PROPN
hls-12456	234	5	-	-	SYM
hls-12456	234	6	105	105	NUM
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hls-12456	235	2	.	.	X
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hls-12456	235	4	si	si	PROPN
hls-12456	235	5	,	,	PUNCT
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hls-12456	235	8	,	,	PUNCT
hls-12456	235	9	lukyanchuk	lukyanchuk	NOUN
hls-12456	235	10	ov	ov	PROPN
hls-12456	235	11	,	,	PUNCT
hls-12456	235	12	et	et	PROPN
hls-12456	235	13	al	al	PROPN
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hls-12456	235	16	and	and	CCONJ
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hls-12456	235	19	affecting	affect	VERB
hls-12456	235	20	public	public	ADJ
hls-12456	235	21	health	health	NOUN
hls-12456	236	1	[	[	X
hls-12456	236	2	healthcare	healthcare	NOUN
hls-12456	236	3	in	in	ADP
hls-12456	236	4	low	low	ADJ
hls-12456	236	5	-	-	PUNCT
hls-12456	236	6	resource	resource	NOUN
hls-12456	236	7	settings	setting	NOUN
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hls-12456	237	7	mmerc	mmerc	PROPN
hls-12456	237	8	ial	ial	PROPN
hls-12456	237	9	us	us	PROPN
hls-12456	237	10	e	e	NOUN
hls-12456	237	11	o	o	NOUN
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hls-12456	237	13	immunoscore	immunoscore	VERB
hls-12456	237	14	and	and	CCONJ
hls-12456	237	15	personification	personification	NOUN
hls-12456	237	16	of	of	ADP
hls-12456	237	17	chemotherapeutic	chemotherapeutic	ADJ
hls-12456	237	18	treatment	treatment	NOUN
hls-12456	237	19	in	in	ADP
hls-12456	237	20	patients	patient	NOUN
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hls-12456	237	22	gastric	gastric	ADJ
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hls-12456	237	24	.	.	PUNCT
hls-12456	238	1	ukr	ukr	PROPN
hls-12456	238	2	j	j	PROPN
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hls-12456	238	5	2020;28:199	2020;28:199	NUM
hls-12456	238	6	-	-	SYM
hls-12456	238	7	207	207	NUM
hls-12456	238	8	.	.	PUNCT
hls-12456	238	9	4	4	X
hls-12456	238	10	.	.	X
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hls-12456	238	13	,	,	PUNCT
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hls-12456	238	15	si	si	PROPN
hls-12456	238	16	,	,	PUNCT
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hls-12456	238	18	om	om	PROPN
hls-12456	238	19	,	,	PUNCT
hls-12456	238	20	et	et	PROPN
hls-12456	238	21	al	al	PROPN
hls-12456	238	22	.	.	PROPN
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hls-12456	238	27	phenotype	phenotype	NOUN
hls-12456	238	28	on	on	ADP
hls-12456	238	29	survival	survival	NOUN
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hls-12456	238	31	patients	patient	NOUN
hls-12456	238	32	with	with	ADP
hls-12456	238	33	gastric	gastric	ADJ
hls-12456	238	34	cancer	cancer	NOUN
hls-12456	238	35	after	after	ADP
hls-12456	238	36	radical	radical	ADJ
hls-12456	238	37	surgery	surgery	NOUN
hls-12456	238	38	.	.	PUNCT
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hls-12456	239	4	-	-	SYM
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hls-12456	239	6	.	.	NOUN
hls-12456	239	7	5	5	NUM
hls-12456	239	8	.	.	PUNCT
hls-12456	239	9	kulak	kulak	PROPN
hls-12456	239	10	mo	mo	PROPN
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hls-12456	240	2	for	for	ADP
hls-12456	240	3	the	the	DET
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hls-12456	240	5	of	of	ADP
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hls-12456	240	8	on	on	ADP
hls-12456	240	9	the	the	DET
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hls-12456	240	14	.	.	PUNCT
hls-12456	241	1	kyiv	kyiv	ADJ
hls-12456	241	2	:	:	PUNCT
hls-12456	241	3	national	national	PROPN
hls-12456	241	4	aviation	aviation	PROPN
hls-12456	241	5	university	university	NOUN
hls-12456	241	6	;	;	PUNCT
hls-12456	241	7	2020	2020	NUM
hls-12456	241	8	.	.	PUNCT
hls-12456	242	1	available	available	ADJ
hls-12456	242	2	from	from	ADP
hls-12456	242	3	:	:	PUNCT
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hls-12456	242	11	6	6	NUM
hls-12456	242	12	.	.	PUNCT
hls-12456	243	1	zhang	zhang	PROPN
hls-12456	243	2	c	c	PROPN
hls-12456	243	3	,	,	PUNCT
hls-12456	243	4	zhao	zhao	PROPN
hls-12456	243	5	y	y	PROPN
hls-12456	243	6	,	,	PUNCT
hls-12456	243	7	xu	xu	PROPN
hls-12456	243	8	x	x	PROPN
hls-12456	243	9	,	,	PUNCT
hls-12456	243	10	et	et	PROPN
hls-12456	243	11	al	al	PROPN
hls-12456	243	12	.	.	PUNCT
hls-12456	244	1	cancer	cancer	NOUN
hls-12456	244	2	diagnosis	diagnosis	NOUN
hls-12456	244	3	with	with	ADP
hls-12456	244	4	dna	dna	PROPN
hls-12456	244	5	molecular	molecular	ADJ
hls-12456	244	6	computation	computation	NOUN
hls-12456	244	7	.	.	PUNCT
hls-12456	245	1	nat	nat	PROPN
hls-12456	245	2	nanotechnol	nanotechnol	PROPN
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hls-12456	245	4	-	-	PUNCT
hls-12456	245	5	15	15	NUM
hls-12456	245	6	.	.	PUNCT
hls-12456	245	7	7	7	NUM
hls-12456	245	8	.	.	X
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hls-12456	246	1	i	i	PRON
hls-12456	246	2	m	m	PROPN
hls-12456	246	3	,	,	PUNCT
hls-12456	246	4	cendón	cendón	PROPN
hls-12456	246	5	y	y	PROPN
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hls-12456	246	8	d	d	PROPN
hls-12456	246	9	,	,	PUNCT
hls-12456	246	10	et	et	PROPN
hls-12456	246	11	al	al	PROPN
hls-12456	246	12	.	.	PUNCT
hls-12456	247	1	implications	implication	NOUN
hls-12456	247	2	of	of	ADP
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hls-12456	247	4	nucleotide	nucleotide	ADJ
hls-12456	247	5	polymorphisms	polymorphism	NOUN
hls-12456	247	6	(	(	PUNCT
hls-12456	247	7	snps	snps	PROPN
hls-12456	247	8	)	)	PUNCT
hls-12456	247	9	in	in	ADP
hls-12456	247	10	androgen	androgen	NOUN
hls-12456	247	11	related	relate	VERB
hls-12456	247	12	-	-	PUNCT
hls-12456	247	13	genes	gene	NOUN
hls-12456	247	14	in	in	ADP
hls-12456	247	15	outcome	outcome	NOUN
hls-12456	247	16	of	of	ADP
hls-12456	247	17	metastatic	metastatic	ADJ
hls-12456	247	18	castration	castration	NOUN
hls-12456	247	19	-	-	PUNCT
hls-12456	247	20	resistant	resistant	ADJ
hls-12456	247	21	prostate	prostate	NOUN
hls-12456	247	22	cancer	cancer	NOUN
hls-12456	247	23	(	(	PUNCT
hls-12456	247	24	mcrpc	mcrpc	NOUN
hls-12456	247	25	)	)	PUNCT
hls-12456	247	26	patients	patient	NOUN
hls-12456	247	27	treated	treat	VERB
hls-12456	247	28	with	with	ADP
hls-12456	247	29	abiraterone	abiraterone	NOUN
hls-12456	247	30	(	(	PUNCT
hls-12456	247	31	abi	abi	PROPN
hls-12456	247	32	)	)	PUNCT
hls-12456	247	33	and	and	CCONJ
hls-12456	247	34	enzalutamide	enzalutamide	ADV
hls-12456	247	35	(	(	PUNCT
hls-12456	247	36	enza	enza	PROPN
hls-12456	247	37	)	)	PUNCT
hls-12456	247	38	.	.	PUNCT
hls-12456	248	1	ann	ann	PROPN
hls-12456	248	2	oncol	oncol	PROPN
hls-12456	248	3	2019;30	2019;30	NUM
hls-12456	248	4	:	:	PUNCT
hls-12456	248	5	v346	v346	NUM
hls-12456	248	6	.	.	NOUN
hls-12456	248	7	8	8	NUM
hls-12456	248	8	.	.	PUNCT
hls-12456	248	9	schulz	schulz	PROPN
hls-12456	248	10	m	m	PROPN
hls-12456	248	11	,	,	PUNCT
hls-12456	248	12	salamero	salamero	NOUN
hls-12456	248	13	-	-	PUNCT
hls-12456	248	14	boix	boix	NOUN
hls-12456	248	15	a	a	NOUN
hls-12456	248	16	,	,	PUNCT
hls-12456	248	17	niesel	niesel	PROPN
hls-12456	248	18	k	k	PROPN
hls-12456	248	19	,	,	PUNCT
hls-12456	248	20	et	et	PROPN
hls-12456	248	21	al	al	PROPN
hls-12456	248	22	.	.	PUNCT
hls-12456	249	1	microenvironmental	microenvironmental	ADJ
hls-12456	249	2	regulation	regulation	NOUN
hls-12456	249	3	of	of	ADP
hls-12456	249	4	tumor	tumor	NOUN
hls-12456	249	5	progression	progression	NOUN
hls-12456	249	6	and	and	CCONJ
hls-12456	249	7	therapeutic	therapeutic	ADJ
hls-12456	249	8	response	response	NOUN
hls-12456	249	9	in	in	ADP
hls-12456	249	10	brain	brain	NOUN
hls-12456	249	11	metastasis	metastasis	NOUN
hls-12456	249	12	.	.	PUNCT
hls-12456	250	1	front	front	ADJ
hls-12456	250	2	immunol	immunol	NOUN
hls-12456	250	3	2019;10:1713	2019;10:1713	ADP
hls-12456	250	4	.	.	PROPN
hls-12456	250	5	9	9	NUM
hls-12456	250	6	.	.	PUNCT
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hls-12456	250	8	l	l	PROPN
hls-12456	250	9	,	,	PUNCT
hls-12456	250	10	ilderbayev	ilderbayev	ADJ
hls-12456	250	11	o	o	NOUN
hls-12456	250	12	,	,	PUNCT
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hls-12456	250	14	z	z	PROPN
hls-12456	250	15	,	,	PUNCT
hls-12456	250	16	et	et	PROPN
hls-12456	250	17	al	al	PROPN
hls-12456	250	18	.	.	PUNCT
hls-12456	250	19	phytocorrection	phytocorrection	NOUN
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hls-12456	250	22	and	and	CCONJ
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hls-12456	250	25	in	in	ADP
hls-12456	250	26	the	the	DET
hls-12456	250	27	combined	combine	VERB
hls-12456	250	28	impact	impact	NOUN
hls-12456	250	29	of	of	ADP
hls-12456	250	30	coal	coal	NOUN
hls-12456	250	31	dust	dust	NOUN
hls-12456	250	32	and	and	CCONJ
hls-12456	250	33	high	high	ADJ
hls-12456	250	34	dose	dose	NOUN
hls-12456	250	35	of	of	ADP
hls-12456	250	36	radiation	radiation	NOUN
hls-12456	250	37	.	.	PUNCT
hls-12456	251	1	georgian	georgian	PROPN
hls-12456	251	2	med	med	PROPN
hls-12456	251	3	news	news	PROPN
hls-12456	251	4	2018;1:141	2018;1:141	PROPN
hls-12456	251	5	-	-	SYM
hls-12456	251	6	50	50	NUM
hls-12456	251	7	.	.	PUNCT
hls-12456	251	8	10	10	NUM
hls-12456	251	9	.	.	PUNCT
hls-12456	252	1	shen	shen	PROPN
hls-12456	253	1	z	z	PROPN
hls-12456	253	2	,	,	PUNCT
hls-12456	253	3	ma	ma	PROPN
hls-12456	253	4	q	q	PROPN
hls-12456	253	5	,	,	PUNCT
hls-12456	253	6	zhou	zhou	PROPN
hls-12456	253	7	x	x	PROPN
hls-12456	253	8	,	,	PUNCT
hls-12456	253	9	et	et	PROPN
hls-12456	253	10	al	al	PROPN
hls-12456	253	11	.	.	PUNCT
hls-12456	253	12	strategies	strategy	NOUN
hls-12456	253	13	to	to	PART
hls-12456	253	14	improve	improve	VERB
hls-12456	253	15	photodynamic	photodynamic	ADJ
hls-12456	253	16	therapy	therapy	NOUN
hls-12456	253	17	efficacy	efficacy	NOUN
hls-12456	253	18	by	by	ADP
hls-12456	253	19	relieving	relieve	VERB
hls-12456	253	20	the	the	DET
hls-12456	253	21	tumor	tumor	NOUN
hls-12456	253	22	hypoxia	hypoxia	NOUN
hls-12456	253	23	environment	environment	NOUN
hls-12456	253	24	.	.	PUNCT
hls-12456	254	1	npg	npg	PROPN
hls-12456	254	2	asia	asia	PROPN
hls-12456	254	3	mater	mater	PROPN
hls-12456	254	4	2021;13:39	2021;13:39	NUM
hls-12456	254	5	.	.	PUNCT
hls-12456	254	6	11	11	NUM
hls-12456	254	7	.	.	X
hls-12456	255	1	sevastre	sevastre	NOUN
hls-12456	255	2	as	as	ADP
hls-12456	255	3	,	,	PUNCT
hls-12456	255	4	manea	manea	PROPN
hls-12456	255	5	ev	ev	PROPN
hls-12456	255	6	,	,	PUNCT
hls-12456	255	7	popescu	popescu	PROPN
hls-12456	255	8	os	os	PROPN
hls-12456	255	9	,	,	PUNCT
hls-12456	255	10	et	et	PROPN
hls-12456	255	11	al	al	PROPN
hls-12456	255	12	.	.	PROPN
hls-12456	255	13	intracellular	intracellular	ADJ
hls-12456	255	14	pathways	pathway	NOUN
hls-12456	255	15	and	and	CCONJ
hls-12456	255	16	mechanisms	mechanism	NOUN
hls-12456	255	17	of	of	ADP
hls-12456	255	18	colored	colored	ADJ
hls-12456	255	19	secondary	secondary	ADJ
hls-12456	255	20	metabolites	metabolite	NOUN
hls-12456	255	21	in	in	ADP
hls-12456	255	22	cancer	cancer	NOUN
hls-12456	255	23	therapy	therapy	NOUN
hls-12456	255	24	.	.	PUNCT
hls-12456	256	1	int	int	PROPN
hls-12456	256	2	j	j	PROPN
hls-12456	256	3	mol	mol	ADP
hls-12456	256	4	sci	sci	PROPN
hls-12456	256	5	2022;23:9943	2022;23:9943	NUM
hls-12456	256	6	.	.	PROPN
hls-12456	256	7	12	12	NUM
hls-12456	256	8	.	.	PUNCT
hls-12456	257	1	hussain	hussain	PROPN
hls-12456	257	2	s	s	PROPN
hls-12456	257	3	,	,	PUNCT
hls-12456	257	4	afzal	afzal	PROPN
hls-12456	257	5	o	o	PROPN
hls-12456	257	6	,	,	PUNCT
hls-12456	257	7	gupta	gupta	PROPN
hls-12456	257	8	g	g	PROPN
hls-12456	257	9	,	,	PUNCT
hls-12456	257	10	et	et	PROPN
hls-12456	257	11	al	al	PROPN
hls-12456	257	12	.	.	PROPN
hls-12456	258	1	long	long	ADJ
hls-12456	258	2	non	non	ADJ
hls-12456	258	3	-	-	ADJ
hls-12456	258	4	coding	coding	ADJ
hls-12456	258	5	rnas	rna	NOUN
hls-12456	258	6	in	in	ADP
hls-12456	258	7	lung	lung	NOUN
hls-12456	258	8	cancer	cancer	NOUN
hls-12456	258	9	:	:	PUNCT
hls-12456	258	10	unraveling	unravel	VERB
hls-12456	258	11	the	the	DET
hls-12456	258	12	molecular	molecular	ADJ
hls-12456	258	13	modulators	modulator	NOUN
hls-12456	258	14	of	of	ADP
hls-12456	258	15	mapk	mapk	NOUN
hls-12456	258	16	signaling	signal	VERB
hls-12456	258	17	.	.	PUNCT
hls-12456	259	1	pathol	pathol	VERB
hls-12456	259	2	res	re	NOUN
hls-12456	259	3	pract	pract	PROPN
hls-12456	259	4	2023;249:154738	2023;249:154738	NUM
hls-12456	259	5	.	.	PUNCT
hls-12456	260	1	13	13	NUM
hls-12456	260	2	.	.	PUNCT
hls-12456	261	1	dykstra	dykstra	PROPN
hls-12456	261	2	pb	pb	PROPN
hls-12456	261	3	,	,	PUNCT
hls-12456	261	4	kaplan	kaplan	PROPN
hls-12456	261	5	m	m	PROPN
hls-12456	261	6	,	,	PUNCT
hls-12456	261	7	smolke	smolke	PROPN
hls-12456	261	8	cd	cd	PROPN
hls-12456	261	9	.	.	PUNCT
hls-12456	262	1	engineering	engineering	NOUN
hls-12456	262	2	synthetic	synthetic	ADJ
hls-12456	262	3	rna	rna	NOUN
hls-12456	262	4	devices	device	NOUN
hls-12456	262	5	for	for	ADP
hls-12456	262	6	cell	cell	NOUN
hls-12456	262	7	control	control	NOUN
hls-12456	262	8	.	.	PUNCT
hls-12456	263	1	nat	nat	PROPN
hls-12456	263	2	rev	rev	PROPN
hls-12456	263	3	genet	genet	PROPN
hls-12456	263	4	2022;23:215	2022;23:215	PROPN
hls-12456	263	5	-	-	PUNCT
hls-12456	263	6	28	28	NUM
hls-12456	263	7	.	.	PUNCT
hls-12456	264	1	14	14	NUM
hls-12456	264	2	.	.	PUNCT
hls-12456	265	1	epum	epum	PROPN
hls-12456	265	2	ea	ea	PROPN
hls-12456	265	3	,	,	PUNCT
hls-12456	265	4	haber	haber	PROPN
hls-12456	265	5	je	je	PROPN
hls-12456	265	6	.	.	PROPN
hls-12456	265	7	dna	dna	PROPN
hls-12456	265	8	replication	replication	NOUN
hls-12456	265	9	:	:	PUNCT
hls-12456	265	10	the	the	DET
hls-12456	265	11	recombination	recombination	NOUN
hls-12456	265	12	connection	connection	NOUN
hls-12456	265	13	.	.	PUNCT
hls-12456	266	1	trends	trend	NOUN
hls-12456	266	2	cell	cell	VERB
hls-12456	266	3	biol	biol	PROPN
hls-12456	266	4	2022;32:45	2022;32:45	NUM
hls-12456	266	5	-	-	SYM
hls-12456	266	6	57	57	NUM
hls-12456	266	7	.	.	PUNCT
hls-12456	266	8	15	15	NUM
hls-12456	266	9	.	.	PUNCT
hls-12456	267	1	khavinson	khavinson	PROPN
hls-12456	267	2	vk	vk	PROPN
hls-12456	267	3	,	,	PUNCT
hls-12456	267	4	popovich	popovich	PROPN
hls-12456	267	5	ig	ig	PROPN
hls-12456	267	6	,	,	PUNCT
hls-12456	267	7	linkova	linkova	PROPN
hls-12456	267	8	ns	n	VERB
hls-12456	267	9	,	,	PUNCT
hls-12456	267	10	et	et	PROPN
hls-12456	267	11	al	al	PROPN
hls-12456	267	12	.	.	PROPN
hls-12456	267	13	peptide	peptide	PROPN
hls-12456	267	14	regulation	regulation	NOUN
hls-12456	267	15	of	of	ADP
hls-12456	267	16	gene	gene	NOUN
hls-12456	267	17	expression	expression	NOUN
hls-12456	267	18	:	:	PUNCT
hls-12456	267	19	a	a	DET
hls-12456	267	20	systematic	systematic	ADJ
hls-12456	267	21	review	review	NOUN
hls-12456	267	22	.	.	PUNCT
hls-12456	268	1	molecules	molecule	NOUN
hls-12456	268	2	2021;26:7053	2021;26:7053	NUM
hls-12456	268	3	.	.	PUNCT
hls-12456	269	1	16	16	NUM
hls-12456	269	2	.	.	PUNCT
hls-12456	270	1	svyatova	svyatova	VERB
hls-12456	270	2	g	g	PROPN
hls-12456	270	3	,	,	PUNCT
hls-12456	270	4	berezina	berezina	PROPN
hls-12456	270	5	g	g	PROPN
hls-12456	270	6	,	,	PUNCT
hls-12456	270	7	urazbayeva	urazbayeva	VERB
hls-12456	270	8	g	g	PROPN
hls-12456	270	9	,	,	PUNCT
hls-12456	270	10	murtazaliyeva	murtazaliyeva	PROPN
hls-12456	270	11	a.	a.	NOUN
hls-12456	270	12	frequencies	frequency	NOUN
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hls-12456	270	14	diagnostically	diagnostically	ADV
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hls-12456	270	16	polymorphisms	polymorphism	NOUN
hls-12456	270	17	of	of	ADP
hls-12456	270	18	hereditary	hereditary	ADJ
hls-12456	270	19	breast	breast	NOUN
hls-12456	270	20	cancer	cancer	NOUN
hls-12456	270	21	forms	form	NOUN
hls-12456	270	22	in	in	ADP
hls-12456	270	23	brca1	brca1	PROPN
hls-12456	270	24	and	and	CCONJ
hls-12456	270	25	brca2	brca2	NOUN
hls-12456	270	26	genes	gene	NOUN
hls-12456	270	27	in	in	ADP
hls-12456	270	28	the	the	DET
hls-12456	270	29	kazakh	kazakh	ADJ
hls-12456	270	30	population	population	NOUN
hls-12456	270	31	.	.	PUNCT
hls-12456	271	1	asian	asian	ADJ
hls-12456	271	2	pacif	pacif	PROPN
hls-12456	271	3	j	j	PROPN
hls-12456	271	4	cancer	cancer	NOUN
hls-12456	271	5	prev	prev	X
hls-12456	271	6	2023;24:3899	2023;24:3899	NUM
hls-12456	271	7	-	-	SYM
hls-12456	271	8	907	907	NUM
hls-12456	271	9	.	.	PUNCT
hls-12456	271	10	17	17	NUM
hls-12456	271	11	.	.	PUNCT
hls-12456	272	1	feunteun	feunteun	PROPN
hls-12456	272	2	j	j	PROPN
hls-12456	272	3	,	,	PUNCT
hls-12456	272	4	ostyn	ostyn	ADV
hls-12456	272	5	p	p	X
hls-12456	272	6	,	,	PUNCT
hls-12456	272	7	delaloge	delaloge	PROPN
hls-12456	272	8	s.	s.	PROPN
hls-12456	272	9	tumor	tumor	PROPN
hls-12456	272	10	cell	cell	NOUN
hls-12456	272	11	malignancy	malignancy	NOUN
hls-12456	272	12	:	:	PUNCT
hls-12456	272	13	a	a	DET
hls-12456	272	14	complex	complex	ADJ
hls-12456	272	15	trait	trait	NOUN
hls-12456	272	16	built	build	VERB
hls-12456	272	17	through	through	ADP
hls-12456	272	18	reciprocal	reciprocal	ADJ
hls-12456	272	19	interactions	interaction	NOUN
hls-12456	272	20	between	between	ADP
hls-12456	272	21	tumors	tumor	NOUN
hls-12456	272	22	and	and	CCONJ
hls-12456	272	23	tissue	tissue	NOUN
hls-12456	272	24	-	-	PUNCT
hls-12456	272	25	body	body	NOUN
hls-12456	272	26	system	system	NOUN
hls-12456	272	27	.	.	PUNCT
hls-12456	273	1	iscience	iscience	NOUN
hls-12456	273	2	2022;25:104217	2022;25:104217	NUM
hls-12456	273	3	.	.	PUNCT
hls-12456	273	4	18	18	NUM
hls-12456	273	5	.	.	PUNCT
hls-12456	274	1	li	li	PROPN
hls-12456	274	2	j	j	PROPN
hls-12456	274	3	,	,	PUNCT
hls-12456	274	4	chen	chen	PROPN
hls-12456	274	5	d	d	PROPN
hls-12456	274	6	,	,	PUNCT
hls-12456	274	7	shen	shen	PROPN
hls-12456	274	8	m.	m.	PROPN
hls-12456	274	9	tumor	tumor	PROPN
hls-12456	274	10	microenvironment	microenvironment	PROPN
hls-12456	274	11	shapes	shape	VERB
hls-12456	274	12	colorectal	colorectal	ADJ
hls-12456	274	13	cancer	cancer	NOUN
hls-12456	274	14	progression	progression	NOUN
hls-12456	274	15	,	,	PUNCT
hls-12456	274	16	metastasis	metastasis	NOUN
hls-12456	274	17	,	,	PUNCT
hls-12456	274	18	and	and	CCONJ
hls-12456	274	19	treatment	treatment	NOUN
hls-12456	274	20	responses	response	NOUN
hls-12456	274	21	.	.	PUNCT
hls-12456	275	1	front	front	ADJ
hls-12456	275	2	med	med	ADJ
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hls-12456	275	4	.	.	PUNCT
hls-12456	276	1	19	19	NUM
hls-12456	276	2	.	.	PROPN
hls-12456	276	3	altayeva	altayeva	PROPN
hls-12456	276	4	aa	aa	PROPN
hls-12456	276	5	,	,	PUNCT
hls-12456	276	6	issenova	issenova	PROPN
hls-12456	276	7	ss	ss	PROPN
hls-12456	276	8	,	,	PUNCT
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hls-12456	276	10	e	e	NOUN
hls-12456	276	11	,	,	PUNCT
hls-12456	276	12	et	et	PROPN
hls-12456	276	13	al	al	PROPN
hls-12456	276	14	.	.	PROPN
hls-12456	276	15	results	result	NOUN
hls-12456	276	16	of	of	ADP
hls-12456	276	17	using	use	VERB
hls-12456	276	18	the	the	DET
hls-12456	276	19	robson	robson	NOUN
hls-12456	276	20	classification	classification	NOUN
hls-12456	276	21	in	in	ADP
hls-12456	276	22	kazakhstan	kazakhstan	PROPN
hls-12456	276	23	.	.	PUNCT
hls-12456	277	1	open	open	ADJ
hls-12456	277	2	access	access	PROPN
hls-12456	277	3	macedonian	macedonian	PROPN
hls-12456	277	4	journal	journal	PROPN
hls-12456	277	5	of	of	ADP
hls-12456	277	6	medical	medical	ADJ
hls-12456	277	7	sciences	science	NOUN
hls-12456	277	8	2021;9:663	2021;9:663	NUM
hls-12456	277	9	-	-	SYM
hls-12456	277	10	9	9	NUM
hls-12456	277	11	.	.	NOUN
hls-12456	277	12	20	20	NUM
hls-12456	277	13	.	.	PUNCT
hls-12456	278	1	pappuswamy	pappuswamy	PROPN
hls-12456	278	2	m	m	PROPN
hls-12456	278	3	,	,	PUNCT
hls-12456	278	4	chaudhary	chaudhary	PROPN
hls-12456	278	5	a	a	X
hls-12456	278	6	,	,	PUNCT
hls-12456	278	7	meyyazhagan	meyyazhagan	NOUN
hls-12456	278	8	a	a	PRON
hls-12456	278	9	,	,	PUNCT
hls-12456	278	10	et	et	PROPN
hls-12456	278	11	al	al	PROPN
hls-12456	278	12	.	.	PROPN
hls-12456	279	1	dna	dna	PROPN
hls-12456	279	2	damage	damage	NOUN
hls-12456	279	3	on	on	ADP
hls-12456	279	4	buccal	buccal	ADJ
hls-12456	279	5	epithelial	epithelial	ADJ
hls-12456	279	6	cells	cell	NOUN
hls-12456	279	7	,	,	PUNCT
hls-12456	279	8	personal	personal	ADJ
hls-12456	279	9	working	work	VERB
hls-12456	279	10	in	in	ADP
hls-12456	279	11	the	the	DET
hls-12456	279	12	rubber	rubber	NOUN
hls-12456	279	13	industry	industry	NOUN
hls-12456	279	14	occupationally	occupationally	ADV
hls-12456	279	15	exposed	expose	VERB
hls-12456	279	16	to	to	ADP
hls-12456	279	17	carbon	carbon	NOUN
hls-12456	279	18	disulfide	disulfide	NOUN
hls-12456	279	19	(	(	PUNCT
hls-12456	279	20	cs2	cs2	NOUN
hls-12456	279	21	)	)	PUNCT
hls-12456	279	22	.	.	PUNCT
hls-12456	280	1	asian	asian	ADJ
hls-12456	280	2	pacif	pacif	PROPN
hls-12456	280	3	j	j	PROPN
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hls-12456	280	5	prev	prev	X
hls-12456	280	6	2023;24:357	2023;24:357	NOUN
hls-12456	280	7	-	-	SYM
hls-12456	280	8	61	61	NUM
hls-12456	280	9	.	.	PUNCT
hls-12456	281	1	21	21	NUM
hls-12456	281	2	.	.	PUNCT
hls-12456	282	1	salimi	salimi	PROPN
hls-12456	282	2	m	m	PROPN
hls-12456	282	3	,	,	PUNCT
hls-12456	282	4	rastegarpouyani	rastegarpouyani	PROPN
hls-12456	282	5	s.	s.	PROPN
hls-12456	282	6	e74	e74	PROPN
hls-12456	282	7	-	-	PUNCT
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hls-12456	282	9	factor	factor	NOUN
hls-12456	282	10	5	5	NUM
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hls-12456	282	12	methylation	methylation	NOUN
hls-12456	282	13	in	in	ADP
hls-12456	282	14	circulating	circulate	VERB
hls-12456	282	15	tumor	tumor	NOUN
hls-12456	282	16	dna	dna	PROPN
hls-12456	282	17	as	as	ADP
hls-12456	282	18	a	a	DET
hls-12456	282	19	potential	potential	ADJ
hls-12456	282	20	prognostic	prognostic	ADJ
hls-12456	282	21	marker	marker	NOUN
hls-12456	282	22	in	in	ADP
hls-12456	282	23	breast	breast	NOUN
hls-12456	282	24	cancer	cancer	NOUN
hls-12456	282	25	patients	patient	NOUN
hls-12456	282	26	.	.	PUNCT
hls-12456	283	1	asian	asian	ADJ
hls-12456	283	2	pacif	pacif	PROPN
hls-12456	283	3	j	j	PROPN
hls-12456	283	4	cancer	cancer	NOUN
hls-12456	283	5	prev	prev	VERB
hls-12456	283	6	2023;24:4035	2023;24:4035	NUM
hls-12456	283	7	-	-	SYM
hls-12456	283	8	41	41	NUM
hls-12456	283	9	.	.	PUNCT
hls-12456	284	1	22	22	NUM
hls-12456	284	2	.	.	PUNCT
hls-12456	285	1	fu	fu	PROPN
hls-12456	285	2	lq	lq	PROPN
hls-12456	285	3	,	,	PUNCT
hls-12456	285	4	du	du	PROPN
hls-12456	285	5	wl	wl	PROPN
hls-12456	285	6	,	,	PUNCT
hls-12456	285	7	cai	cai	PROPN
hls-12456	285	8	mh	mh	PROPN
hls-12456	285	9	,	,	PUNCT
hls-12456	285	10	et	et	PROPN
hls-12456	285	11	al	al	PROPN
hls-12456	285	12	.	.	PUNCT
hls-12456	286	1	the	the	DET
hls-12456	286	2	roles	role	NOUN
hls-12456	286	3	of	of	ADP
hls-12456	286	4	tumor	tumor	NOUN
hls-12456	286	5	-	-	PUNCT
hls-12456	286	6	associated	associate	VERB
hls-12456	286	7	macrophages	macrophage	NOUN
hls-12456	286	8	in	in	ADP
hls-12456	286	9	tumor	tumor	NOUN
hls-12456	286	10	angiogenesis	angiogenesis	NOUN
hls-12456	286	11	and	and	CCONJ
hls-12456	286	12	metastasis	metastasis	NOUN
hls-12456	286	13	.	.	PUNCT
hls-12456	287	1	cell	cell	NOUN
hls-12456	287	2	immunol	immunol	NOUN
hls-12456	287	3	2020;353:104119	2020;353:104119	NUM
hls-12456	287	4	.	.	PROPN
hls-12456	288	1	23	23	NUM
hls-12456	288	2	.	.	PUNCT
hls-12456	289	1	abdi	abdi	PROPN
hls-12456	289	2	e	e	PROPN
hls-12456	289	3	,	,	PUNCT
hls-12456	289	4	latifi	latifi	PROPN
hls-12456	289	5	-	-	PUNCT
hls-12456	289	6	navid	navid	PROPN
hls-12456	289	7	s.	s.	PROPN
hls-12456	289	8	emerging	emerge	VERB
hls-12456	289	9	long	long	ADV
hls-12456	289	10	noncoding	noncode	VERB
hls-12456	289	11	rna	rna	NOUN
hls-12456	289	12	polymorphisms	polymorphism	NOUN
hls-12456	289	13	as	as	ADP
hls-12456	289	14	novel	novel	ADJ
hls-12456	289	15	predictors	predictor	NOUN
hls-12456	289	16	of	of	ADP
hls-12456	289	17	survival	survival	NOUN
hls-12456	289	18	in	in	ADP
hls-12456	289	19	cancer	cancer	NOUN
hls-12456	289	20	.	.	PUNCT
hls-12456	290	1	pathol	pathol	VERB
hls-12456	290	2	res	re	NOUN
hls-12456	290	3	pract	pract	PROPN
hls-12456	290	4	2022;239:154165	2022;239:154165	NUM
hls-12456	290	5	.	.	PUNCT
hls-12456	291	1	24	24	NUM
hls-12456	291	2	.	.	PUNCT
hls-12456	292	1	hirna	hirna	PROPN
hls-12456	292	2	ha	ha	INTJ
hls-12456	292	3	,	,	PUNCT
hls-12456	292	4	maltsev	maltsev	PROPN
hls-12456	292	5	dv	dv	PROPN
hls-12456	292	6	,	,	PUNCT
hls-12456	292	7	natrus	natrus	PROPN
hls-12456	292	8	lv	lv	PROPN
hls-12456	292	9	,	,	PUNCT
hls-12456	292	10	et	et	PROPN
hls-12456	292	11	al	al	PROPN
hls-12456	292	12	.	.	PROPN
hls-12456	292	13	study	study	NOUN
hls-12456	292	14	of	of	ADP
hls-12456	292	15	the	the	DET
hls-12456	292	16	immunomodulating	immunomodulate	VERB
hls-12456	292	17	influence	influence	NOUN
hls-12456	292	18	of	of	ADP
hls-12456	292	19	preparation	preparation	NOUN
hls-12456	292	20	alpha	alpha	NOUN
hls-12456	292	21	/	/	SYM
hls-12456	292	22	betadefensins	betadefensin	NOUN
hls-12456	292	23	on	on	ADP
hls-12456	292	24	chemo	chemo	NOUN
hls-12456	292	25	/	/	SYM
hls-12456	292	26	radiotherapy	radiotherapy	NOUN
hls-12456	292	27	of	of	ADP
hls-12456	292	28	patients	patient	NOUN
hls-12456	292	29	with	with	ADP
hls-12456	292	30	oral	oral	ADJ
hls-12456	292	31	and	and	CCONJ
hls-12456	292	32	oropharyngeal	oropharyngeal	NOUN
hls-12456	292	33	cancer	cancer	NOUN
hls-12456	292	34	.	.	PUNCT
hls-12456	293	1	fiziologich	fiziologich	PROPN
hls-12456	293	2	zhurn	zhurn	VERB
hls-12456	293	3	2021;67:86	2021;67:86	NUM
hls-12456	293	4	-	-	SYM
hls-12456	293	5	96	96	NUM
hls-12456	293	6	.	.	PUNCT
hls-12456	294	1	25	25	NUM
hls-12456	294	2	.	.	PUNCT
hls-12456	295	1	mazziotta	mazziotta	PROPN
hls-12456	295	2	c	c	PROPN
hls-12456	295	3	,	,	PUNCT
hls-12456	295	4	lanzillotti	lanzillotti	PROPN
hls-12456	295	5	c	c	NOUN
hls-12456	295	6	,	,	PUNCT
hls-12456	295	7	iaquinta	iaquinta	VERB
hls-12456	295	8	mr	mr	PROPN
hls-12456	295	9	,	,	PUNCT
hls-12456	295	10	et	et	PROPN
hls-12456	295	11	al	al	PROPN
hls-12456	295	12	.	.	PROPN
hls-12456	295	13	micrornas	microrna	NOUN
hls-12456	295	14	modulate	modulate	VERB
hls-12456	295	15	signalling	signal	VERB
hls-12456	295	16	pathways	pathway	NOUN
hls-12456	295	17	in	in	ADP
hls-12456	295	18	osteogenic	osteogenic	ADJ
hls-12456	295	19	differentiation	differentiation	NOUN
hls-12456	295	20	of	of	ADP
hls-12456	295	21	mesenchymal	mesenchymal	ADJ
hls-12456	295	22	stem	stem	NOUN
hls-12456	295	23	cells	cell	NOUN
hls-12456	295	24	.	.	PUNCT
hls-12456	296	1	int	int	PROPN
hls-12456	296	2	j	j	PROPN
hls-12456	296	3	mol	mol	ADP
hls-12456	296	4	sci	sci	PROPN
hls-12456	296	5	2021;22:2362	2021;22:2362	NUM
hls-12456	296	6	.	.	PUNCT
hls-12456	297	1	social	social	ADJ
hls-12456	297	2	and	and	CCONJ
hls-12456	297	3	political	political	ADJ
hls-12456	297	4	factors	factor	NOUN
hls-12456	297	5	affecting	affect	VERB
hls-12456	297	6	public	public	ADJ
hls-12456	297	7	health	health	NOUN
hls-12456	298	1	[	[	X
hls-12456	298	2	page	page	NOUN
hls-12456	298	3	82	82	NUM
hls-12456	298	4	]	]	PUNCT
hls-12456	299	1	[	[	X
hls-12456	299	2	healthcare	healthcare	NOUN
hls-12456	299	3	in	in	ADP
hls-12456	299	4	low	low	ADJ
hls-12456	299	5	-	-	PUNCT
hls-12456	299	6	resource	resource	NOUN
hls-12456	299	7	settings	setting	NOUN
hls-12456	299	8	2024;12(s2):12456	2024;12(s2):12456	NUM
hls-12456	299	9	]	]	X
hls-12456	299	10	non	non	ADJ
hls-12456	299	11	-co	-co	PROPN
hls-12456	299	12	mmerc	mmerc	PROPN
hls-12456	299	13	ial	ial	PROPN
hls-12456	299	14	us	us	PROPN
hls-12456	299	15	e	e	NOUN
hls-12456	299	16	o	o	NOUN
hls-12456	299	17	nly	nly	ADV