id	sid	tid	token	lemma	pos
bioscience-245	1	1	highlights	highlight	NOUN
bioscience-245	1	2	in	in	ADP
bioscience-245	1	3	bioscience	bioscience	PROPN
bioscience-245	1	4	issn:2682	issn:2682	PROPN
bioscience-245	1	5	-	-	PUNCT
bioscience-245	1	6	4043	4043	NUM
bioscience-245	1	7	doi:10.36462	doi:10.36462	NOUN
bioscience-245	1	8	/	/	SYM
bioscience-245	1	9	h.biosci.202503	h.biosci.202503	PROPN
bioscience-245	1	10	research	research	NOUN
bioscience-245	1	11	article	article	NOUN
bioscience-245	1	12	open	open	ADJ
bioscience-245	1	13	access	access	NOUN
bioscience-245	1	14	1	1	NUM
bioscience-245	1	15	department	department	NOUN
bioscience-245	1	16	of	of	ADP
bioscience-245	1	17	biology	biology	NOUN
bioscience-245	1	18	,	,	PUNCT
bioscience-245	1	19	tbilisi	tbilisi	PROPN
bioscience-245	1	20	state	state	PROPN
bioscience-245	1	21	university	university	PROPN
bioscience-245	1	22	,	,	PUNCT
bioscience-245	1	23	georgia	georgia	PROPN
bioscience-245	1	24	.	.	PROPN
bioscience-245	2	1	2	2	NUM
bioscience-245	2	2	department	department	NOUN
bioscience-245	2	3	of	of	ADP
bioscience-245	2	4	biology	biology	NOUN
bioscience-245	2	5	,	,	PUNCT
bioscience-245	2	6	ivane	ivane	NOUN
bioscience-245	2	7	javakhishvili	javakhishvili	NOUN
bioscience-245	2	8	tbilisi	tbilisi	PROPN
bioscience-245	2	9	state	state	PROPN
bioscience-245	2	10	university	university	PROPN
bioscience-245	2	11	,	,	PUNCT
bioscience-245	2	12	georgia	georgia	PROPN
bioscience-245	2	13	.	.	PUNCT
bioscience-245	3	1	*	*	PUNCT
bioscience-245	3	2	to	to	PART
bioscience-245	3	3	whom	whom	PRON
bioscience-245	3	4	correspondence	correspondence	NOUN
bioscience-245	3	5	should	should	AUX
bioscience-245	3	6	be	be	AUX
bioscience-245	3	7	addressed	address	VERB
bioscience-245	3	8	:	:	PUNCT
bioscience-245	3	9	temuri.mantashashvili6037@ens.tsu.edu.ge	temuri.mantashashvili6037@ens.tsu.edu.ge	ADP
bioscience-245	3	10	editor	editor	NOUN
bioscience-245	3	11	:	:	PUNCT
bioscience-245	3	12	hatem	hatem	PROPN
bioscience-245	3	13	zayed	zayed	PROPN
bioscience-245	3	14	,	,	PUNCT
bioscience-245	3	15	department	department	NOUN
bioscience-245	3	16	of	of	ADP
bioscience-245	3	17	biomedical	biomedical	ADJ
bioscience-245	3	18	science	science	NOUN
bioscience-245	3	19	,	,	PUNCT
bioscience-245	3	20	college	college	NOUN
bioscience-245	3	21	of	of	ADP
bioscience-245	3	22	health	health	PROPN
bioscience-245	3	23	sciences	sciences	PROPN
bioscience-245	3	24	,	,	PUNCT
bioscience-245	3	25	qatar	qatar	PROPN
bioscience-245	3	26	university	university	PROPN
bioscience-245	3	27	,	,	PUNCT
bioscience-245	3	28	doha	doha	PROPN
bioscience-245	3	29	,	,	PUNCT
bioscience-245	3	30	qatar	qatar	PROPN
bioscience-245	3	31	.	.	PUNCT
bioscience-245	4	1	reviewer(s	reviewer(s	NOUN
bioscience-245	4	2	):	):	PUNCT
bioscience-245	4	3	hayder	hayder	NOUN
bioscience-245	4	4	tawfeeq	tawfeeq	PROPN
bioscience-245	4	5	,	,	PUNCT
bioscience-245	4	6	middle	middle	PROPN
bioscience-245	4	7	technical	technical	PROPN
bioscience-245	4	8	university	university	PROPN
bioscience-245	4	9	,	,	PUNCT
bioscience-245	4	10	technical	technical	ADJ
bioscience-245	4	11	instituteof	instituteof	X
bioscience-245	4	12	baqubah	baqubah	NOUN
bioscience-245	4	13	,	,	PUNCT
bioscience-245	4	14	department	department	NOUN
bioscience-245	4	15	of	of	ADP
bioscience-245	4	16	nursing	nursing	NOUN
bioscience-245	4	17	,	,	PUNCT
bioscience-245	4	18	dayala	dayala	PROPN
bioscience-245	4	19	,	,	PUNCT
bioscience-245	4	20	iraq	iraq	PROPN
bioscience-245	4	21	.	.	PUNCT
bioscience-245	5	1	asmaa	asmaa	PROPN
bioscience-245	5	2	hassan	hassan	PROPN
bioscience-245	5	3	,	,	PUNCT
bioscience-245	5	4	agricultural	agricultural	ADJ
bioscience-245	5	5	genetic	genetic	ADJ
bioscience-245	5	6	engineering	engineering	NOUN
bioscience-245	5	7	research	research	PROPN
bioscience-245	5	8	institute	institute	PROPN
bioscience-245	5	9	,	,	PUNCT
bioscience-245	5	10	agriculture	agriculture	NOUN
bioscience-245	5	11	research	research	NOUN
bioscience-245	5	12	center	center	NOUN
bioscience-245	5	13	,	,	PUNCT
bioscience-245	5	14	giza	giza	PROPN
bioscience-245	5	15	,	,	PUNCT
bioscience-245	5	16	egypt	egypt	PROPN
bioscience-245	5	17	.	.	PUNCT
bioscience-245	5	18	received	receive	VERB
bioscience-245	5	19	:	:	PUNCT
bioscience-245	5	20	february	february	PROPN
bioscience-245	5	21	12	12	NUM
bioscience-245	5	22	,	,	PUNCT
bioscience-245	5	23	2025	2025	NUM
bioscience-245	5	24	accepted	accept	VERB
bioscience-245	5	25	:	:	PUNCT
bioscience-245	5	26	june	june	PROPN
bioscience-245	5	27	04	04	NUM
bioscience-245	5	28	,	,	PUNCT
bioscience-245	5	29	2025	2025	NUM
bioscience-245	5	30	published	publish	VERB
bioscience-245	5	31	:	:	PUNCT
bioscience-245	5	32	june	june	PROPN
bioscience-245	5	33	20	20	NUM
bioscience-245	5	34	,	,	PUNCT
bioscience-245	5	35	2025	2025	NUM
bioscience-245	5	36	citation	citation	NOUN
bioscience-245	5	37	:	:	PUNCT
bioscience-245	5	38	mantashashvili	mantashashvili	PROPN
bioscience-245	5	39	t	t	PROPN
bioscience-245	5	40	,	,	PUNCT
bioscience-245	5	41	nakaidze	nakaidze	ADJ
bioscience-245	5	42	l	l	NOUN
bioscience-245	5	43	,	,	PUNCT
bioscience-245	5	44	ananiashvili	ananiashvili	PROPN
bioscience-245	5	45	g	g	PROPN
bioscience-245	5	46	,	,	PUNCT
bioscience-245	5	47	burjanadze	burjanadze	ADJ
bioscience-245	5	48	g	g	NOUN
bioscience-245	5	49	,	,	PUNCT
bioscience-245	5	50	koshoridze	koshoridze	ADJ
bioscience-245	5	51	n.	n.	PROPN
bioscience-245	5	52	l	l	NOUN
bioscience-245	5	53	-	-	NOUN
bioscience-245	5	54	arginine	arginine	NOUN
bioscience-245	5	55	as	as	ADP
bioscience-245	5	56	a	a	DET
bioscience-245	5	57	potential	potential	ADJ
bioscience-245	5	58	antidepressant	antidepressant	NOUN
bioscience-245	5	59	:	:	PUNCT
bioscience-245	5	60	effects	effect	NOUN
bioscience-245	5	61	on	on	ADP
bioscience-245	5	62	cognitive	cognitive	ADJ
bioscience-245	5	63	function	function	NOUN
bioscience-245	5	64	and	and	CCONJ
bioscience-245	5	65	antioxidant	antioxidant	ADJ
bioscience-245	5	66	enzyme	enzyme	NOUN
bioscience-245	5	67	activity	activity	NOUN
bioscience-245	5	68	in	in	ADP
bioscience-245	5	69	depressed	depressed	ADJ
bioscience-245	5	70	rats	rat	NOUN
bioscience-245	5	71	.	.	PUNCT
bioscience-245	6	1	2025	2025	NUM
bioscience-245	6	2	june	june	PROPN
bioscience-245	6	3	20;8	20;8	NUM
bioscience-245	6	4	:	:	PUNCT
bioscience-245	6	5	bs202503	bs202503	PROPN
bioscience-245	6	6	copyright	copyright	NOUN
bioscience-245	6	7	:	:	PUNCT
bioscience-245	6	8	©	©	PROPN
bioscience-245	6	9	2025	2025	NUM
bioscience-245	6	10	mantashashvili	mantashashvili	NOUN
bioscience-245	6	11	t	t	PROPN
bioscience-245	6	12	et	et	PROPN
bioscience-245	6	13	al	al	PROPN
bioscience-245	6	14	..	..	PROPN
bioscience-245	7	1	this	this	PRON
bioscience-245	7	2	is	be	AUX
bioscience-245	7	3	an	an	DET
bioscience-245	7	4	open	open	ADJ
bioscience-245	7	5	access	access	NOUN
bioscience-245	7	6	article	article	NOUN
bioscience-245	7	7	distributed	distribute	VERB
bioscience-245	7	8	under	under	ADP
bioscience-245	7	9	the	the	DET
bioscience-245	7	10	terms	term	NOUN
bioscience-245	7	11	of	of	ADP
bioscience-245	7	12	the	the	DET
bioscience-245	7	13	creative	creative	ADJ
bioscience-245	7	14	commons	common	NOUN
bioscience-245	7	15	attribution	attribution	NOUN
bioscience-245	7	16	license	license	NOUN
bioscience-245	7	17	,	,	PUNCT
bioscience-245	7	18	which	which	PRON
bioscience-245	7	19	permits	permit	VERB
bioscience-245	7	20	unrestricted	unrestricted	ADJ
bioscience-245	7	21	use	use	NOUN
bioscience-245	7	22	,	,	PUNCT
bioscience-245	7	23	distribution	distribution	NOUN
bioscience-245	7	24	,	,	PUNCT
bioscience-245	7	25	and	and	CCONJ
bioscience-245	7	26	reproduction	reproduction	NOUN
bioscience-245	7	27	in	in	ADP
bioscience-245	7	28	any	any	DET
bioscience-245	7	29	medium	medium	NOUN
bioscience-245	7	30	,	,	PUNCT
bioscience-245	7	31	provided	provide	VERB
bioscience-245	7	32	the	the	DET
bioscience-245	7	33	original	original	ADJ
bioscience-245	7	34	author	author	NOUN
bioscience-245	7	35	and	and	CCONJ
bioscience-245	7	36	source	source	NOUN
bioscience-245	7	37	are	be	AUX
bioscience-245	7	38	credited	credit	VERB
bioscience-245	7	39	.	.	PUNCT
bioscience-245	8	1	data	datum	NOUN
bioscience-245	8	2	availability	availability	NOUN
bioscience-245	8	3	statement	statement	NOUN
bioscience-245	8	4	:	:	PUNCT
bioscience-245	8	5	all	all	DET
bioscience-245	8	6	relevant	relevant	ADJ
bioscience-245	8	7	data	datum	NOUN
bioscience-245	8	8	are	be	AUX
bioscience-245	8	9	within	within	ADP
bioscience-245	8	10	the	the	DET
bioscience-245	8	11	paper	paper	NOUN
bioscience-245	8	12	and	and	CCONJ
bioscience-245	8	13	supplementary	supplementary	ADJ
bioscience-245	8	14	materials	material	NOUN
bioscience-245	8	15	.	.	PUNCT
bioscience-245	9	1	funding	funding	NOUN
bioscience-245	9	2	:	:	PUNCT
bioscience-245	9	3	the	the	DET
bioscience-245	9	4	authors	author	NOUN
bioscience-245	9	5	have	have	VERB
bioscience-245	9	6	no	no	DET
bioscience-245	9	7	support	support	NOUN
bioscience-245	9	8	or	or	CCONJ
bioscience-245	9	9	funding	funding	NOUN
bioscience-245	9	10	to	to	PART
bioscience-245	9	11	report	report	VERB
bioscience-245	9	12	.	.	PUNCT
bioscience-245	10	1	competing	compete	VERB
bioscience-245	10	2	interests	interest	NOUN
bioscience-245	10	3	:	:	PUNCT
bioscience-245	10	4	the	the	DET
bioscience-245	10	5	authors	author	NOUN
bioscience-245	10	6	declare	declare	VERB
bioscience-245	10	7	that	that	SCONJ
bioscience-245	10	8	they	they	PRON
bioscience-245	10	9	have	have	VERB
bioscience-245	10	10	no	no	DET
bioscience-245	10	11	competing	compete	VERB
bioscience-245	10	12	interests	interest	NOUN
bioscience-245	10	13	.	.	PUNCT
bioscience-245	11	1	l	l	NOUN
bioscience-245	11	2	-	-	NOUN
bioscience-245	11	3	arginine	arginine	NOUN
bioscience-245	11	4	as	as	ADP
bioscience-245	11	5	a	a	DET
bioscience-245	11	6	potential	potential	ADJ
bioscience-245	11	7	antidepressant	antidepressant	NOUN
bioscience-245	11	8	:	:	PUNCT
bioscience-245	11	9	effects	effect	NOUN
bioscience-245	11	10	on	on	ADP
bioscience-245	11	11	cognitive	cognitive	ADJ
bioscience-245	11	12	function	function	NOUN
bioscience-245	11	13	and	and	CCONJ
bioscience-245	11	14	antioxidant	antioxidant	ADJ
bioscience-245	11	15	enzyme	enzyme	NOUN
bioscience-245	11	16	activity	activity	NOUN
bioscience-245	11	17	in	in	ADP
bioscience-245	11	18	depressed	depressed	ADJ
bioscience-245	11	19	rats	rat	NOUN
bioscience-245	11	20	temuri	temuri	PROPN
bioscience-245	11	21	mantashashvili*1,2	mantashashvili*1,2	PROPN
bioscience-245	11	22	>	>	X
bioscience-245	11	23	<	<	X
bioscience-245	11	24	�	�	PROPN
bioscience-245	11	25	,	,	PUNCT
bioscience-245	11	26	luka	luka	PROPN
bioscience-245	11	27	nakaidze1,2	nakaidze1,2	PROPN
bioscience-245	11	28	>	>	X
bioscience-245	11	29	<	<	X
bioscience-245	11	30	,	,	PUNCT
bioscience-245	11	31	giorgi	giorgi	PROPN
bioscience-245	11	32	ananiashvili1,2	ananiashvili1,2	PROPN
bioscience-245	11	33	>	>	X
bioscience-245	11	34	<	<	X
bioscience-245	11	35	,	,	PUNCT
bioscience-245	11	36	george	george	PROPN
bioscience-245	11	37	burjanadze1,2	burjanadze1,2	PROPN
bioscience-245	11	38	>	>	ADP
bioscience-245	11	39	<	<	X
bioscience-245	11	40	�	�	PROPN
bioscience-245	11	41	,	,	PUNCT
bioscience-245	11	42	nana	nana	PROPN
bioscience-245	11	43	koshoridze1,2	koshoridze1,2	PROPN
bioscience-245	12	1	>	>	PUNCT
bioscience-245	12	2	<	<	X
bioscience-245	12	3	�	�	PROPN
bioscience-245	12	4	abstract	abstract	NOUN
bioscience-245	12	5	the	the	DET
bioscience-245	12	6	potential	potential	ADJ
bioscience-245	12	7	antidepressant	antidepressant	ADJ
bioscience-245	12	8	effects	effect	NOUN
bioscience-245	12	9	of	of	ADP
bioscience-245	12	10	dietary	dietary	ADJ
bioscience-245	12	11	l	l	NOUN
bioscience-245	12	12	-	-	NOUN
bioscience-245	12	13	arginine	arginine	NOUN
bioscience-245	12	14	(	(	PUNCT
bioscience-245	12	15	l	l	NOUN
bioscience-245	12	16	-	-	NOUN
bioscience-245	12	17	arg	arg	NOUN
bioscience-245	12	18	)	)	PUNCT
bioscience-245	12	19	were	be	AUX
bioscience-245	12	20	investigated	investigate	VERB
bioscience-245	12	21	in	in	ADP
bioscience-245	12	22	male	male	ADJ
bioscience-245	12	23	white	white	ADJ
bioscience-245	12	24	laboratory	laboratory	NOUN
bioscience-245	12	25	rats	rat	NOUN
bioscience-245	12	26	with	with	ADP
bioscience-245	12	27	corticosterone	corticosterone	NOUN
bioscience-245	12	28	-	-	PUNCT
bioscience-245	12	29	induced	induce	VERB
bioscience-245	12	30	depression	depression	NOUN
bioscience-245	12	31	.	.	PUNCT
bioscience-245	13	1	daily	daily	ADJ
bioscience-245	13	2	administration	administration	NOUN
bioscience-245	13	3	of	of	ADP
bioscience-245	13	4	l	l	PROPN
bioscience-245	13	5	-	-	NOUN
bioscience-245	13	6	arg	arg	NOUN
bioscience-245	13	7	at	at	ADP
bioscience-245	13	8	a	a	DET
bioscience-245	13	9	dose	dose	NOUN
bioscience-245	13	10	of	of	ADP
bioscience-245	13	11	150	150	NUM
bioscience-245	13	12	mg	mg	PROPN
bioscience-245	13	13	/	/	SYM
bioscience-245	13	14	kg	kg	PROPN
bioscience-245	13	15	for	for	ADP
bioscience-245	13	16	14	14	NUM
bioscience-245	13	17	consecutive	consecutive	ADJ
bioscience-245	13	18	days	day	NOUN
bioscience-245	13	19	significantly	significantly	ADV
bioscience-245	13	20	alleviated	alleviate	VERB
bioscience-245	13	21	depressive	depressive	ADJ
bioscience-245	13	22	-	-	PUNCT
bioscience-245	13	23	like	like	ADJ
bioscience-245	13	24	behaviors	behavior	NOUN
bioscience-245	13	25	and	and	CCONJ
bioscience-245	13	26	improved	improve	VERB
bioscience-245	13	27	cognitive	cognitive	ADJ
bioscience-245	13	28	performance	performance	NOUN
bioscience-245	13	29	.	.	PUNCT
bioscience-245	14	1	furthermore	furthermore	ADV
bioscience-245	14	2	,	,	PUNCT
bioscience-245	14	3	l	l	ADJ
bioscience-245	14	4	-	-	ADJ
bioscience-245	14	5	arg	arg	NOUN
bioscience-245	14	6	supplementation	supplementation	NOUN
bioscience-245	14	7	restored	restore	VERB
bioscience-245	14	8	serotonin	serotonin	NOUN
bioscience-245	14	9	levels	level	NOUN
bioscience-245	14	10	in	in	ADP
bioscience-245	14	11	the	the	DET
bioscience-245	14	12	prefrontal	prefrontal	ADJ
bioscience-245	14	13	cortex	cortex	NOUN
bioscience-245	14	14	and	and	CCONJ
bioscience-245	14	15	hippocampus	hippocampus	PROPN
bioscience-245	14	16	,	,	PUNCT
bioscience-245	14	17	which	which	PRON
bioscience-245	14	18	had	have	AUX
bioscience-245	14	19	been	be	AUX
bioscience-245	14	20	reduced	reduce	VERB
bioscience-245	14	21	following	follow	VERB
bioscience-245	14	22	intraperitoneal	intraperitoneal	ADJ
bioscience-245	14	23	corticosterone	corticosterone	NOUN
bioscience-245	14	24	injection	injection	NOUN
bioscience-245	14	25	.	.	PUNCT
bioscience-245	15	1	to	to	PART
bioscience-245	15	2	evaluate	evaluate	VERB
bioscience-245	15	3	the	the	DET
bioscience-245	15	4	antioxidant	antioxidant	ADJ
bioscience-245	15	5	properties	property	NOUN
bioscience-245	15	6	of	of	ADP
bioscience-245	15	7	l	l	NOUN
bioscience-245	15	8	-	-	NOUN
bioscience-245	15	9	arg	arg	VERB
bioscience-245	15	10	,	,	PUNCT
bioscience-245	15	11	quantitative	quantitative	ADJ
bioscience-245	15	12	changes	change	NOUN
bioscience-245	15	13	in	in	ADP
bioscience-245	15	14	malondialdehyde	malondialdehyde	PROPN
bioscience-245	15	15	(	(	PUNCT
bioscience-245	15	16	mda	mda	PROPN
bioscience-245	15	17	)	)	PUNCT
bioscience-245	15	18	and	and	CCONJ
bioscience-245	15	19	nitric	nitric	ADJ
bioscience-245	15	20	oxide	oxide	NOUN
bioscience-245	15	21	(	(	PUNCT
bioscience-245	15	22	no	no	NOUN
bioscience-245	15	23	)	)	PUNCT
bioscience-245	15	24	levels	level	NOUN
bioscience-245	15	25	were	be	AUX
bioscience-245	15	26	measured	measure	VERB
bioscience-245	15	27	in	in	ADP
bioscience-245	15	28	the	the	DET
bioscience-245	15	29	prefrontal	prefrontal	ADJ
bioscience-245	15	30	cortex	cortex	NOUN
bioscience-245	15	31	and	and	CCONJ
bioscience-245	15	32	hippocampal	hippocampal	ADJ
bioscience-245	15	33	cells	cell	NOUN
bioscience-245	15	34	of	of	ADP
bioscience-245	15	35	depressive	depressive	ADJ
bioscience-245	15	36	rats	rat	NOUN
bioscience-245	15	37	following	follow	VERB
bioscience-245	15	38	l	l	ADJ
bioscience-245	15	39	-	-	ADJ
bioscience-245	15	40	arg	arg	NOUN
bioscience-245	15	41	administration	administration	NOUN
bioscience-245	15	42	.	.	PUNCT
bioscience-245	16	1	the	the	DET
bioscience-245	16	2	findings	finding	NOUN
bioscience-245	16	3	revealed	reveal	VERB
bioscience-245	16	4	that	that	SCONJ
bioscience-245	16	5	l	l	NOUN
bioscience-245	16	6	-	-	ADJ
bioscience-245	16	7	arg	arg	NOUN
bioscience-245	16	8	normalized	normalize	VERB
bioscience-245	16	9	lipid	lipid	NOUN
bioscience-245	16	10	peroxidation	peroxidation	NOUN
bioscience-245	16	11	processes	process	NOUN
bioscience-245	16	12	that	that	PRON
bioscience-245	16	13	had	have	AUX
bioscience-245	16	14	been	be	AUX
bioscience-245	16	15	enhanced	enhance	VERB
bioscience-245	16	16	under	under	ADP
bioscience-245	16	17	depressive	depressive	ADJ
bioscience-245	16	18	conditions	condition	NOUN
bioscience-245	16	19	.	.	PUNCT
bioscience-245	17	1	l	l	X
bioscience-245	17	2	-	-	ADJ
bioscience-245	17	3	arg	arg	NOUN
bioscience-245	17	4	treatment	treatment	NOUN
bioscience-245	17	5	significantly	significantly	ADV
bioscience-245	17	6	reduced	reduce	VERB
bioscience-245	17	7	elevated	elevated	ADJ
bioscience-245	17	8	levels	level	NOUN
bioscience-245	17	9	of	of	ADP
bioscience-245	17	10	these	these	DET
bioscience-245	17	11	oxidative	oxidative	ADJ
bioscience-245	17	12	stress	stress	NOUN
bioscience-245	17	13	markers	marker	NOUN
bioscience-245	17	14	.	.	PUNCT
bioscience-245	18	1	additionally	additionally	ADV
bioscience-245	18	2	,	,	PUNCT
bioscience-245	18	3	it	it	PRON
bioscience-245	18	4	increased	increase	VERB
bioscience-245	18	5	the	the	DET
bioscience-245	18	6	activity	activity	NOUN
bioscience-245	18	7	of	of	ADP
bioscience-245	18	8	key	key	ADJ
bioscience-245	18	9	antioxidant	antioxidant	ADJ
bioscience-245	18	10	enzymes	enzyme	NOUN
bioscience-245	18	11	,	,	PUNCT
bioscience-245	18	12	including	include	VERB
bioscience-245	18	13	mitochondrial	mitochondrial	ADJ
bioscience-245	18	14	superoxide	superoxide	NOUN
bioscience-245	18	15	dismutase	dismutase	NOUN
bioscience-245	18	16	(	(	PUNCT
bioscience-245	18	17	sod	sod	NOUN
bioscience-245	18	18	)	)	PUNCT
bioscience-245	18	19	and	and	CCONJ
bioscience-245	18	20	catalase	catalase	NOUN
bioscience-245	18	21	,	,	PUNCT
bioscience-245	18	22	whose	whose	DET
bioscience-245	18	23	activities	activity	NOUN
bioscience-245	18	24	had	have	AUX
bioscience-245	18	25	been	be	AUX
bioscience-245	18	26	suppressed	suppress	VERB
bioscience-245	18	27	in	in	ADP
bioscience-245	18	28	the	the	DET
bioscience-245	18	29	depressive	depressive	ADJ
bioscience-245	18	30	state	state	NOUN
bioscience-245	18	31	.	.	PUNCT
bioscience-245	19	1	kinetic	kinetic	ADJ
bioscience-245	19	2	analysis	analysis	NOUN
bioscience-245	19	3	of	of	ADP
bioscience-245	19	4	enzymatic	enzymatic	ADJ
bioscience-245	19	5	reactions	reaction	NOUN
bioscience-245	19	6	indicated	indicate	VERB
bioscience-245	19	7	that	that	SCONJ
bioscience-245	19	8	the	the	DET
bioscience-245	19	9	increased	increase	VERB
bioscience-245	19	10	activity	activity	NOUN
bioscience-245	19	11	of	of	ADP
bioscience-245	19	12	these	these	DET
bioscience-245	19	13	antioxidant	antioxidant	ADJ
bioscience-245	19	14	enzymes	enzyme	NOUN
bioscience-245	19	15	in	in	ADP
bioscience-245	19	16	the	the	DET
bioscience-245	19	17	brain	brain	NOUN
bioscience-245	19	18	cells	cell	NOUN
bioscience-245	19	19	of	of	ADP
bioscience-245	19	20	depressive	depressive	ADJ
bioscience-245	19	21	rats	rat	NOUN
bioscience-245	19	22	was	be	AUX
bioscience-245	19	23	not	not	PART
bioscience-245	19	24	due	due	ADJ
bioscience-245	19	25	to	to	ADP
bioscience-245	19	26	structural	structural	ADJ
bioscience-245	19	27	modifications	modification	NOUN
bioscience-245	19	28	of	of	ADP
bioscience-245	19	29	the	the	DET
bioscience-245	19	30	enzymes	enzyme	NOUN
bioscience-245	19	31	,	,	PUNCT
bioscience-245	19	32	but	but	CCONJ
bioscience-245	19	33	rather	rather	ADV
bioscience-245	19	34	to	to	ADP
bioscience-245	19	35	an	an	DET
bioscience-245	19	36	increase	increase	NOUN
bioscience-245	19	37	in	in	ADP
bioscience-245	19	38	their	their	PRON
bioscience-245	19	39	abundance	abundance	NOUN
bioscience-245	19	40	.	.	PUNCT
bioscience-245	20	1	this	this	DET
bioscience-245	20	2	effect	effect	NOUN
bioscience-245	20	3	is	be	AUX
bioscience-245	20	4	likely	likely	ADV
bioscience-245	20	5	attributable	attributable	ADJ
bioscience-245	20	6	to	to	ADP
bioscience-245	20	7	the	the	DET
bioscience-245	20	8	activation	activation	NOUN
bioscience-245	20	9	of	of	ADP
bioscience-245	20	10	biosynthetic	biosynthetic	ADJ
bioscience-245	20	11	processes	process	NOUN
bioscience-245	20	12	in	in	ADP
bioscience-245	20	13	brain	brain	NOUN
bioscience-245	20	14	cells	cell	NOUN
bioscience-245	20	15	triggered	trigger	VERB
bioscience-245	20	16	by	by	ADP
bioscience-245	20	17	l	l	NOUN
bioscience-245	20	18	-	-	ADJ
bioscience-245	20	19	arg	arg	NOUN
bioscience-245	20	20	administration	administration	NOUN
bioscience-245	20	21	.	.	PUNCT
bioscience-245	21	1	keywords	keyword	NOUN
bioscience-245	21	2	:	:	PUNCT
bioscience-245	21	3	depression	depression	NOUN
bioscience-245	21	4	,	,	PUNCT
bioscience-245	21	5	l	l	NOUN
bioscience-245	21	6	-	-	NOUN
bioscience-245	21	7	arginine	arginine	NOUN
bioscience-245	21	8	,	,	PUNCT
bioscience-245	21	9	fluoxetine	fluoxetine	NOUN
bioscience-245	21	10	,	,	PUNCT
bioscience-245	21	11	antioxidant	antioxidant	ADJ
bioscience-245	21	12	system	system	NOUN
bioscience-245	21	13	,	,	PUNCT
bioscience-245	21	14	corticosterone	corticosterone	NOUN
bioscience-245	21	15	introduction	introduction	NOUN
bioscience-245	21	16	depression	depression	NOUN
bioscience-245	21	17	is	be	AUX
bioscience-245	21	18	a	a	DET
bioscience-245	21	19	prevalent	prevalent	ADJ
bioscience-245	21	20	mental	mental	ADJ
bioscience-245	21	21	disorder	disorder	NOUN
bioscience-245	21	22	with	with	ADP
bioscience-245	21	23	serious	serious	ADJ
bioscience-245	21	24	personal	personal	ADJ
bioscience-245	21	25	and	and	CCONJ
bioscience-245	21	26	socio	socio	NOUN
bioscience-245	21	27	-	-	PUNCT
bioscience-245	21	28	economic	economic	ADJ
bioscience-245	21	29	consequences	consequence	NOUN
bioscience-245	21	30	[	[	X
bioscience-245	21	31	1	1	NUM
bioscience-245	21	32	;	;	PUNCT
bioscience-245	21	33	2	2	NUM
bioscience-245	21	34	]	]	PUNCT
bioscience-245	21	35	.	.	PUNCT
bioscience-245	22	1	it	it	PRON
bioscience-245	22	2	is	be	AUX
bioscience-245	22	3	characterized	characterize	VERB
bioscience-245	22	4	by	by	ADP
bioscience-245	22	5	a	a	DET
bioscience-245	22	6	wide	wide	ADJ
bioscience-245	22	7	spectrum	spectrum	NOUN
bioscience-245	22	8	of	of	ADP
bioscience-245	22	9	symptoms	symptom	NOUN
bioscience-245	22	10	that	that	PRON
bioscience-245	22	11	significantly	significantly	ADV
bioscience-245	22	12	impair	impair	VERB
bioscience-245	22	13	quality	quality	NOUN
bioscience-245	22	14	of	of	ADP
bioscience-245	22	15	life	life	NOUN
bioscience-245	22	16	[	[	X
bioscience-245	22	17	3	3	NUM
bioscience-245	22	18	]	]	PUNCT
bioscience-245	22	19	.	.	PUNCT
bioscience-245	23	1	despite	despite	SCONJ
bioscience-245	23	2	extensive	extensive	ADJ
bioscience-245	23	3	research	research	NOUN
bioscience-245	23	4	efforts	effort	NOUN
bioscience-245	23	5	,	,	PUNCT
bioscience-245	23	6	the	the	DET
bioscience-245	23	7	precise	precise	ADJ
bioscience-245	23	8	pathophysiology	pathophysiology	NOUN
bioscience-245	23	9	of	of	ADP
bioscience-245	23	10	depression	depression	NOUN
bioscience-245	23	11	and	and	CCONJ
bioscience-245	23	12	effective	effective	ADJ
bioscience-245	23	13	treatment	treatment	NOUN
bioscience-245	23	14	strategies	strategy	NOUN
bioscience-245	23	15	remain	remain	AUX
bioscience-245	23	16	incompletely	incompletely	ADV
bioscience-245	23	17	understood	understand	VERB
bioscience-245	23	18	.	.	PUNCT
bioscience-245	24	1	a	a	DET
bioscience-245	24	2	growing	grow	VERB
bioscience-245	24	3	body	body	NOUN
bioscience-245	24	4	of	of	ADP
bioscience-245	24	5	evidence	evidence	NOUN
bioscience-245	24	6	highlights	highlight	VERB
bioscience-245	24	7	the	the	DET
bioscience-245	24	8	role	role	NOUN
bioscience-245	24	9	of	of	ADP
bioscience-245	24	10	oxidative	oxidative	ADJ
bioscience-245	24	11	stress	stress	NOUN
bioscience-245	24	12	in	in	ADP
bioscience-245	24	13	the	the	DET
bioscience-245	24	14	pathogenesis	pathogenesis	NOUN
bioscience-245	24	15	of	of	ADP
bioscience-245	24	16	depression	depression	NOUN
bioscience-245	24	17	,	,	PUNCT
bioscience-245	24	18	marked	mark	VERB
bioscience-245	24	19	by	by	ADP
bioscience-245	24	20	increased	increase	VERB
bioscience-245	24	21	production	production	NOUN
bioscience-245	24	22	of	of	ADP
bioscience-245	24	23	reactive	reactive	ADJ
bioscience-245	24	24	oxygen	oxygen	NOUN
bioscience-245	24	25	species	specie	NOUN
bioscience-245	24	26	(	(	PUNCT
bioscience-245	24	27	ros	ros	PROPN
bioscience-245	24	28	)	)	PUNCT
bioscience-245	24	29	and	and	CCONJ
bioscience-245	24	30	diminished	diminish	VERB
bioscience-245	24	31	activity	activity	NOUN
bioscience-245	24	32	of	of	ADP
bioscience-245	24	33	antioxidant	antioxidant	ADJ
bioscience-245	24	34	defense	defense	NOUN
bioscience-245	24	35	enzymes	enzyme	NOUN
bioscience-245	24	36	.	.	PUNCT
bioscience-245	25	1	oxidative	oxidative	ADJ
bioscience-245	25	2	imbalance	imbalance	NOUN
bioscience-245	25	3	,	,	PUNCT
bioscience-245	25	4	in	in	ADP
bioscience-245	25	5	turn	turn	NOUN
bioscience-245	25	6	,	,	PUNCT
bioscience-245	25	7	disrupts	disrupt	VERB
bioscience-245	25	8	essential	essential	ADJ
bioscience-245	25	9	metabolic	metabolic	NOUN
bioscience-245	25	10	processes	process	NOUN
bioscience-245	25	11	.	.	PUNCT
bioscience-245	26	1	antioxidants	antioxidant	NOUN
bioscience-245	26	2	are	be	AUX
bioscience-245	26	3	known	know	VERB
bioscience-245	26	4	to	to	PART
bioscience-245	26	5	protect	protect	VERB
bioscience-245	26	6	mitochondrial	mitochondrial	ADJ
bioscience-245	26	7	structures	structure	NOUN
bioscience-245	26	8	and	and	CCONJ
bioscience-245	26	9	dna	dna	NOUN
bioscience-245	26	10	from	from	ADP
bioscience-245	26	11	oxidative	oxidative	ADJ
bioscience-245	26	12	damage	damage	NOUN
bioscience-245	26	13	.	.	PUNCT
bioscience-245	27	1	during	during	ADP
bioscience-245	27	2	depression	depression	NOUN
bioscience-245	27	3	,	,	PUNCT
bioscience-245	27	4	mitochondrial	mitochondrial	ADJ
bioscience-245	27	5	dysfunction	dysfunction	NOUN
bioscience-245	27	6	leads	lead	VERB
bioscience-245	27	7	to	to	ADP
bioscience-245	27	8	atp	atp	NOUN
bioscience-245	27	9	deficiency	deficiency	NOUN
bioscience-245	27	10	,	,	PUNCT
bioscience-245	27	11	impairing	impair	VERB
bioscience-245	27	12	neuronal	neuronal	ADJ
bioscience-245	27	13	function	function	NOUN
bioscience-245	27	14	and	and	CCONJ
bioscience-245	27	15	contributing	contribute	VERB
bioscience-245	27	16	to	to	ADP
bioscience-245	27	17	what	what	PRON
bioscience-245	27	18	is	be	AUX
bioscience-245	27	19	often	often	ADV
bioscience-245	27	20	referred	refer	VERB
bioscience-245	27	21	to	to	ADP
bioscience-245	27	22	as	as	ADP
bioscience-245	27	23	“	"	PUNCT
bioscience-245	27	24	cellular	cellular	ADJ
bioscience-245	27	25	energy	energy	NOUN
bioscience-245	27	26	depression	depression	NOUN
bioscience-245	27	27	”	"	PUNCT
bioscience-245	28	1	[	[	X
bioscience-245	28	2	4	4	NUM
bioscience-245	28	3	;	;	PUNCT
bioscience-245	28	4	5	5	NUM
bioscience-245	28	5	]	]	PUNCT
bioscience-245	28	6	.	.	PUNCT
bioscience-245	29	1	hormonal	hormonal	ADJ
bioscience-245	29	2	dysregulation	dysregulation	NOUN
bioscience-245	29	3	,	,	PUNCT
bioscience-245	29	4	particularly	particularly	ADV
bioscience-245	29	5	involving	involve	VERB
bioscience-245	29	6	the	the	DET
bioscience-245	29	7	hypothalamic	hypothalamic	NOUN
bioscience-245	29	8	-	-	PUNCT
bioscience-245	29	9	pituitaryadrenal	pituitaryadrenal	ADJ
bioscience-245	29	10	(	(	PUNCT
bioscience-245	29	11	hpa	hpa	NOUN
bioscience-245	29	12	)	)	PUNCT
bioscience-245	29	13	axis	axis	NOUN
bioscience-245	29	14	,	,	PUNCT
bioscience-245	29	15	also	also	ADV
bioscience-245	29	16	plays	play	VERB
bioscience-245	29	17	a	a	DET
bioscience-245	29	18	critical	critical	ADJ
bioscience-245	29	19	role	role	NOUN
bioscience-245	29	20	in	in	ADP
bioscience-245	29	21	depression	depression	NOUN
bioscience-245	29	22	.	.	PUNCT
bioscience-245	30	1	activation	activation	NOUN
bioscience-245	30	2	of	of	ADP
bioscience-245	30	3	this	this	DET
bioscience-245	30	4	system	system	NOUN
bioscience-245	30	5	can	can	AUX
bioscience-245	30	6	promote	promote	VERB
bioscience-245	30	7	free	free	ADJ
bioscience-245	30	8	radical	radical	ADJ
bioscience-245	30	9	production	production	NOUN
bioscience-245	30	10	.	.	PUNCT
bioscience-245	31	1	for	for	ADP
bioscience-245	31	2	example	example	NOUN
bioscience-245	31	3	,	,	PUNCT
bioscience-245	31	4	elevated	elevated	ADJ
bioscience-245	31	5	cortisol	cortisol	ADJ
bioscience-245	31	6	levels	level	NOUN
bioscience-245	31	7	observed	observe	VERB
bioscience-245	31	8	in	in	ADP
bioscience-245	31	9	depressed	depressed	ADJ
bioscience-245	31	10	patients	patient	NOUN
bioscience-245	31	11	may	may	AUX
bioscience-245	31	12	be	be	AUX
bioscience-245	31	13	caused	cause	VERB
bioscience-245	31	14	by	by	ADP
bioscience-245	31	15	oxidative	oxidative	ADJ
bioscience-245	31	16	damage	damage	NOUN
bioscience-245	31	17	to	to	ADP
bioscience-245	31	18	receptor	receptor	NOUN
bioscience-245	31	19	systems	system	NOUN
bioscience-245	31	20	or	or	CCONJ
bioscience-245	31	21	reduced	reduce	VERB
bioscience-245	31	22	cytochrome	cytochrome	ADJ
bioscience-245	31	23	p450	p450	NUM
bioscience-245	31	24	activity	activity	NOUN
bioscience-245	31	25	,	,	PUNCT
bioscience-245	31	26	both	both	PRON
bioscience-245	31	27	of	of	ADP
bioscience-245	31	28	which	which	PRON
bioscience-245	31	29	can	can	AUX
bioscience-245	31	30	be	be	AUX
bioscience-245	31	31	linked	link	VERB
bioscience-245	31	32	to	to	PART
bioscience-245	31	33	oxidative	oxidative	ADJ
bioscience-245	31	34	stress	stress	NOUN
bioscience-245	31	35	[	[	X
bioscience-245	31	36	6	6	NUM
bioscience-245	31	37	;	;	PUNCT
bioscience-245	31	38	7	7	NUM
bioscience-245	31	39	]	]	PUNCT
bioscience-245	31	40	.	.	PUNCT
bioscience-245	32	1	however	however	ADV
bioscience-245	32	2	,	,	PUNCT
bioscience-245	32	3	despite	despite	SCONJ
bioscience-245	32	4	continued	continued	ADJ
bioscience-245	32	5	investigation	investigation	NOUN
bioscience-245	32	6	,	,	PUNCT
bioscience-245	32	7	the	the	DET
bioscience-245	32	8	primary	primary	ADJ
bioscience-245	32	9	initiating	initiate	VERB
bioscience-245	32	10	mechanism	mechanism	NOUN
bioscience-245	32	11	of	of	ADP
bioscience-245	32	12	depression	depression	NOUN
bioscience-245	32	13	remains	remain	VERB
bioscience-245	32	14	elusive	elusive	ADJ
bioscience-245	32	15	.	.	PUNCT
bioscience-245	33	1	most	most	ADJ
bioscience-245	33	2	currently	currently	ADV
bioscience-245	33	3	available	available	ADJ
bioscience-245	33	4	antidepressants	antidepressant	NOUN
bioscience-245	33	5	target	target	VERB
bioscience-245	33	6	monoaminergic	monoaminergic	ADJ
bioscience-245	33	7	pathways	pathway	NOUN
bioscience-245	33	8	in	in	ADP
bioscience-245	33	9	the	the	DET
bioscience-245	33	10	brain	brain	NOUN
bioscience-245	33	11	,	,	PUNCT
bioscience-245	33	12	acting	act	VERB
bioscience-245	33	13	primarily	primarily	ADV
bioscience-245	33	14	as	as	ADP
bioscience-245	33	15	enzyme	enzyme	NOUN
bioscience-245	33	16	inhibitors	inhibitor	NOUN
bioscience-245	33	17	that	that	PRON
bioscience-245	33	18	prevent	prevent	VERB
bioscience-245	33	19	neurotransmitter	neurotransmitter	NOUN
bioscience-245	33	20	degradation	degradation	NOUN
bioscience-245	33	21	or	or	CCONJ
bioscience-245	33	22	block	block	VERB
bioscience-245	33	23	their	their	PRON
bioscience-245	33	24	reuptake	reuptake	NOUN
bioscience-245	33	25	.	.	PUNCT
bioscience-245	34	1	nevertheless	nevertheless	ADV
bioscience-245	34	2	,	,	PUNCT
bioscience-245	34	3	these	these	DET
bioscience-245	34	4	drugs	drug	NOUN
bioscience-245	34	5	are	be	AUX
bioscience-245	34	6	often	often	ADV
bioscience-245	34	7	associated	associate	VERB
bioscience-245	34	8	with	with	ADP
bioscience-245	34	9	limited	limited	ADJ
bioscience-245	34	10	efficacy	efficacy	NOUN
bioscience-245	34	11	,	,	PUNCT
bioscience-245	34	12	a	a	DET
bioscience-245	34	13	delayed	delay	VERB
bioscience-245	34	14	onset	onset	NOUN
bioscience-245	34	15	of	of	ADP
bioscience-245	34	16	therapeutic	therapeutic	ADJ
bioscience-245	34	17	action	action	NOUN
bioscience-245	34	18	(	(	PUNCT
bioscience-245	34	19	typically	typically	ADV
bioscience-245	34	20	2–3	2–3	NUM
bioscience-245	34	21	weeks	week	NOUN
bioscience-245	34	22	or	or	CCONJ
bioscience-245	34	23	more	more	ADJ
bioscience-245	34	24	)	)	PUNCT
bioscience-245	34	25	,	,	PUNCT
bioscience-245	34	26	and	and	CCONJ
bioscience-245	34	27	various	various	ADJ
bioscience-245	34	28	adverse	adverse	ADJ
bioscience-245	34	29	effects	effect	NOUN
bioscience-245	34	30	[	[	X
bioscience-245	34	31	8	8	NUM
bioscience-245	34	32	;	;	PUNCT
bioscience-245	34	33	9	9	NUM
bioscience-245	34	34	]	]	PUNCT
bioscience-245	34	35	.	.	PUNCT
bioscience-245	35	1	these	these	DET
bioscience-245	35	2	limitations	limitation	NOUN
bioscience-245	35	3	have	have	AUX
bioscience-245	35	4	led	lead	VERB
bioscience-245	35	5	to	to	ADP
bioscience-245	35	6	a	a	DET
bioscience-245	35	7	search	search	NOUN
bioscience-245	35	8	for	for	ADP
bioscience-245	35	9	novel	novel	ADJ
bioscience-245	35	10	antidepressants	antidepressant	NOUN
bioscience-245	35	11	that	that	PRON
bioscience-245	35	12	act	act	VERB
bioscience-245	35	13	through	through	ADP
bioscience-245	35	14	alternative	alternative	ADJ
bioscience-245	35	15	mechanisms	mechanism	NOUN
bioscience-245	35	16	.	.	PUNCT
bioscience-245	36	1	in	in	ADP
bioscience-245	36	2	the	the	DET
bioscience-245	36	3	late	late	ADJ
bioscience-245	36	4	1990s	1990	NOUN
bioscience-245	36	5	,	,	PUNCT
bioscience-245	36	6	interest	interest	NOUN
bioscience-245	36	7	grew	grow	VERB
bioscience-245	36	8	around	around	ADP
bioscience-245	36	9	agents	agent	NOUN
bioscience-245	36	10	such	such	ADJ
bioscience-245	36	11	as	as	ADP
bioscience-245	36	12	ketamine	ketamine	NOUN
bioscience-245	36	13	,	,	PUNCT
bioscience-245	36	14	which	which	PRON
bioscience-245	36	15	highlights	highlight	NOUN
bioscience-245	36	16	in	in	ADP
bioscience-245	36	17	bioscience	bioscience	NOUN
bioscience-245	36	18	page	page	NOUN
bioscience-245	36	19	1	1	NUM
bioscience-245	36	20	of	of	ADP
bioscience-245	36	21	7	7	NUM
bioscience-245	36	22	june	june	PROPN
bioscience-245	36	23	2025|volume	2025|volume	NUM
bioscience-245	36	24	8	8	NUM
bioscience-245	36	25	https://doi.org/10.36462/h.biosci.202503	https://doi.org/10.36462/h.biosci.202503	ADJ
bioscience-245	36	26	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
bioscience-245	36	27	mailto:temuri.mantashashvili6037@ens.tsu.edu.ge	mailto:temuri.mantashashvili6037@ens.tsu.edu.ge	PROPN
bioscience-245	36	28	https://orcid.org/0000-0002-9738-1027	https://orcid.org/0000-0002-9738-1027	PROPN
bioscience-245	36	29	mailto:luka.nakaidze155@ens.tsu.edu.ge	mailto:luka.nakaidze155@ens.tsu.edu.ge	ADJ
bioscience-245	36	30	mailto:giorgi.ananiashvili342@ens.tsu.edu.ge	mailto:giorgi.ananiashvili342@ens.tsu.edu.ge	NOUN
bioscience-245	36	31	mailto:giorgi.burjanadze@tsu.ge	mailto:giorgi.burjanadze@tsu.ge	NOUN
bioscience-245	37	1	http://orcid.org/0000-0002-5404-0644	http://orcid.org/0000-0002-5404-0644	ADJ
bioscience-245	37	2	mailto:nana.koshoridze@tsu.ge	mailto:nana.koshoridze@tsu.ge	NOUN
bioscience-245	37	3	http://orcid.org/0000-0001-7324-1495	http://orcid.org/0000-0001-7324-1495	PROPN
bioscience-245	37	4	http://bioscience.highlightsin.org/	http://bioscience.highlightsin.org/	PROPN
bioscience-245	37	5	mantashashvili	mantashashvili	NOUN
bioscience-245	37	6	t	t	PROPN
bioscience-245	37	7	et	et	PROPN
bioscience-245	37	8	al	al	PROPN
bioscience-245	37	9	.	.	PROPN
bioscience-245	37	10	,	,	PUNCT
bioscience-245	37	11	2025	2025	NUM
bioscience-245	37	12	l	l	NOUN
bioscience-245	37	13	-	-	NOUN
bioscience-245	37	14	arginine	arginine	NOUN
bioscience-245	37	15	as	as	ADP
bioscience-245	37	16	a	a	DET
bioscience-245	37	17	potential	potential	ADJ
bioscience-245	37	18	antidepressant	antidepressant	NOUN
bioscience-245	37	19	:	:	PUNCT
bioscience-245	37	20	effects	effect	NOUN
bioscience-245	37	21	on	on	ADP
bioscience-245	37	22	cognitive	cognitive	ADJ
bioscience-245	37	23	function	function	NOUN
bioscience-245	37	24	figure	figure	NOUN
bioscience-245	37	25	1	1	NUM
bioscience-245	37	26	.	.	PUNCT
bioscience-245	37	27	scheme	scheme	NOUN
bioscience-245	37	28	of	of	ADP
bioscience-245	37	29	studying	study	VERB
bioscience-245	37	30	the	the	DET
bioscience-245	37	31	effect	effect	NOUN
bioscience-245	37	32	of	of	ADP
bioscience-245	37	33	exogenous	exogenous	ADJ
bioscience-245	37	34	l	l	NOUN
bioscience-245	37	35	-	-	NOUN
bioscience-245	37	36	arginine	arginine	NOUN
bioscience-245	37	37	on	on	ADP
bioscience-245	37	38	depression	depression	NOUN
bioscience-245	37	39	induced	induce	VERB
bioscience-245	37	40	by	by	ADP
bioscience-245	37	41	corticosterone	corticosterone	NOUN
bioscience-245	37	42	administration	administration	NOUN
bioscience-245	37	43	.	.	PUNCT
bioscience-245	38	1	modulate	modulate	VERB
bioscience-245	38	2	the	the	DET
bioscience-245	38	3	glutamatergic	glutamatergic	ADJ
bioscience-245	38	4	system	system	NOUN
bioscience-245	38	5	[	[	X
bioscience-245	38	6	10	10	NUM
bioscience-245	38	7	;	;	PUNCT
bioscience-245	38	8	11	11	NUM
bioscience-245	38	9	]	]	PUNCT
bioscience-245	38	10	.	.	PUNCT
bioscience-245	39	1	the	the	DET
bioscience-245	39	2	rapid	rapid	ADJ
bioscience-245	39	3	antidepressant	antidepressant	ADJ
bioscience-245	39	4	action	action	NOUN
bioscience-245	39	5	of	of	ADP
bioscience-245	39	6	ketamine	ketamine	PROPN
bioscience-245	39	7	has	have	AUX
bioscience-245	39	8	been	be	AUX
bioscience-245	39	9	attributed	attribute	VERB
bioscience-245	39	10	to	to	ADP
bioscience-245	39	11	activation	activation	NOUN
bioscience-245	39	12	of	of	ADP
bioscience-245	39	13	the	the	DET
bioscience-245	39	14	mtor	mtor	NOUN
bioscience-245	39	15	signaling	signal	VERB
bioscience-245	39	16	pathway	pathway	NOUN
bioscience-245	39	17	in	in	ADP
bioscience-245	39	18	the	the	DET
bioscience-245	39	19	hypothalamus	hypothalamus	NOUN
bioscience-245	39	20	and	and	CCONJ
bioscience-245	39	21	prefrontal	prefrontal	ADJ
bioscience-245	39	22	cortex	cortex	NOUN
bioscience-245	39	23	.	.	PUNCT
bioscience-245	40	1	however	however	ADV
bioscience-245	40	2	,	,	PUNCT
bioscience-245	40	3	the	the	DET
bioscience-245	40	4	clinical	clinical	ADJ
bioscience-245	40	5	utility	utility	NOUN
bioscience-245	40	6	of	of	ADP
bioscience-245	40	7	ketamine	ketamine	PROPN
bioscience-245	40	8	is	be	AUX
bioscience-245	40	9	limited	limit	VERB
bioscience-245	40	10	by	by	ADP
bioscience-245	40	11	its	its	PRON
bioscience-245	40	12	side	side	ADJ
bioscience-245	40	13	effect	effect	NOUN
bioscience-245	40	14	profile	profile	NOUN
bioscience-245	40	15	[	[	X
bioscience-245	40	16	12	12	NUM
bioscience-245	40	17	;	;	PUNCT
bioscience-245	40	18	13	13	NUM
bioscience-245	40	19	]	]	PUNCT
bioscience-245	40	20	.	.	PUNCT
bioscience-245	41	1	given	give	VERB
bioscience-245	41	2	this	this	DET
bioscience-245	41	3	context	context	NOUN
bioscience-245	41	4	,	,	PUNCT
bioscience-245	41	5	the	the	DET
bioscience-245	41	6	identification	identification	NOUN
bioscience-245	41	7	of	of	ADP
bioscience-245	41	8	new	new	ADJ
bioscience-245	41	9	compounds	compound	NOUN
bioscience-245	41	10	with	with	ADP
bioscience-245	41	11	antidepressant	antidepressant	ADJ
bioscience-245	41	12	effects	effect	NOUN
bioscience-245	41	13	and	and	CCONJ
bioscience-245	41	14	fewer	few	ADJ
bioscience-245	41	15	adverse	adverse	ADJ
bioscience-245	41	16	outcomes	outcome	NOUN
bioscience-245	41	17	is	be	AUX
bioscience-245	41	18	of	of	ADP
bioscience-245	41	19	significant	significant	ADJ
bioscience-245	41	20	interest	interest	NOUN
bioscience-245	41	21	.	.	PUNCT
bioscience-245	42	1	one	one	NUM
bioscience-245	42	2	such	such	ADJ
bioscience-245	42	3	candidate	candidate	NOUN
bioscience-245	42	4	is	be	AUX
bioscience-245	42	5	the	the	DET
bioscience-245	42	6	amino	amino	NOUN
bioscience-245	42	7	acid	acid	NOUN
bioscience-245	42	8	l	l	NOUN
bioscience-245	42	9	-	-	NOUN
bioscience-245	42	10	arginine	arginine	NOUN
bioscience-245	42	11	.	.	PUNCT
bioscience-245	43	1	dietary	dietary	ADJ
bioscience-245	43	2	l	l	NOUN
bioscience-245	43	3	-	-	NOUN
bioscience-245	43	4	arginine	arginine	NOUN
bioscience-245	43	5	is	be	AUX
bioscience-245	43	6	absorbed	absorb	VERB
bioscience-245	43	7	in	in	ADP
bioscience-245	43	8	the	the	DET
bioscience-245	43	9	small	small	ADJ
bioscience-245	43	10	intestine	intestine	NOUN
bioscience-245	43	11	and	and	CCONJ
bioscience-245	43	12	distributed	distribute	VERB
bioscience-245	43	13	throughout	throughout	ADP
bioscience-245	43	14	the	the	DET
bioscience-245	43	15	body	body	NOUN
bioscience-245	43	16	.	.	PUNCT
bioscience-245	44	1	it	it	PRON
bioscience-245	44	2	is	be	AUX
bioscience-245	44	3	metabolized	metabolize	VERB
bioscience-245	44	4	along	along	ADP
bioscience-245	44	5	several	several	ADJ
bioscience-245	44	6	pathways	pathway	NOUN
bioscience-245	44	7	:	:	PUNCT
bioscience-245	44	8	converted	convert	VERB
bioscience-245	44	9	into	into	ADP
bioscience-245	44	10	ornithine	ornithine	NOUN
bioscience-245	44	11	and	and	CCONJ
bioscience-245	44	12	urea	urea	NOUN
bioscience-245	44	13	,	,	PUNCT
bioscience-245	44	14	acts	act	VERB
bioscience-245	44	15	as	as	ADP
bioscience-245	44	16	a	a	DET
bioscience-245	44	17	nitrogen	nitrogen	NOUN
bioscience-245	44	18	donor	donor	NOUN
bioscience-245	44	19	,	,	PUNCT
bioscience-245	44	20	participates	participate	VERB
bioscience-245	44	21	in	in	ADP
bioscience-245	44	22	transamination	transamination	NOUN
bioscience-245	44	23	,	,	PUNCT
bioscience-245	44	24	and	and	CCONJ
bioscience-245	44	25	facilitates	facilitate	VERB
bioscience-245	44	26	the	the	DET
bioscience-245	44	27	elimination	elimination	NOUN
bioscience-245	44	28	of	of	ADP
bioscience-245	44	29	protein	protein	NOUN
bioscience-245	44	30	catabolites	catabolite	NOUN
bioscience-245	44	31	.	.	PUNCT
bioscience-245	45	1	ornithine	ornithine	NOUN
bioscience-245	45	2	,	,	PUNCT
bioscience-245	45	3	a	a	DET
bioscience-245	45	4	metabolic	metabolic	NOUN
bioscience-245	45	5	product	product	NOUN
bioscience-245	45	6	of	of	ADP
bioscience-245	45	7	l	l	NOUN
bioscience-245	45	8	-	-	NOUN
bioscience-245	45	9	arginine	arginine	NOUN
bioscience-245	45	10	,	,	PUNCT
bioscience-245	45	11	serves	serve	VERB
bioscience-245	45	12	as	as	ADP
bioscience-245	45	13	a	a	DET
bioscience-245	45	14	precursor	precursor	NOUN
bioscience-245	45	15	for	for	ADP
bioscience-245	45	16	the	the	DET
bioscience-245	45	17	synthesis	synthesis	NOUN
bioscience-245	45	18	of	of	ADP
bioscience-245	45	19	collagen	collagen	NOUN
bioscience-245	45	20	and	and	CCONJ
bioscience-245	45	21	polyamines	polyamine	NOUN
bioscience-245	45	22	[	[	X
bioscience-245	45	23	14	14	NUM
bioscience-245	45	24	;	;	PUNCT
bioscience-245	45	25	15	15	NUM
bioscience-245	45	26	]	]	PUNCT
bioscience-245	45	27	.	.	PUNCT
bioscience-245	46	1	in	in	ADP
bioscience-245	46	2	parallel	parallel	ADJ
bioscience-245	46	3	,	,	PUNCT
bioscience-245	46	4	nitric	nitric	ADJ
bioscience-245	46	5	oxide	oxide	NOUN
bioscience-245	46	6	(	(	PUNCT
bioscience-245	46	7	no	no	NOUN
bioscience-245	46	8	)	)	PUNCT
bioscience-245	46	9	,	,	PUNCT
bioscience-245	46	10	synthesized	synthesize	VERB
bioscience-245	46	11	from	from	ADP
bioscience-245	46	12	l	l	NOUN
bioscience-245	46	13	-	-	NOUN
bioscience-245	46	14	arginine	arginine	NOUN
bioscience-245	46	15	,	,	PUNCT
bioscience-245	46	16	functions	function	NOUN
bioscience-245	46	17	as	as	ADP
bioscience-245	46	18	a	a	DET
bioscience-245	46	19	key	key	ADJ
bioscience-245	46	20	signaling	signal	VERB
bioscience-245	46	21	molecule	molecule	NOUN
bioscience-245	46	22	involved	involve	VERB
bioscience-245	46	23	in	in	ADP
bioscience-245	46	24	vasodilation	vasodilation	NOUN
bioscience-245	46	25	,	,	PUNCT
bioscience-245	46	26	synaptic	synaptic	ADJ
bioscience-245	46	27	plasticity	plasticity	NOUN
bioscience-245	46	28	,	,	PUNCT
bioscience-245	46	29	learning	learning	NOUN
bioscience-245	46	30	and	and	CCONJ
bioscience-245	46	31	memory	memory	NOUN
bioscience-245	46	32	,	,	PUNCT
bioscience-245	46	33	and	and	CCONJ
bioscience-245	46	34	the	the	DET
bioscience-245	46	35	modulation	modulation	NOUN
bioscience-245	46	36	of	of	ADP
bioscience-245	46	37	neuronal	neuronal	ADJ
bioscience-245	46	38	activity	activity	NOUN
bioscience-245	46	39	during	during	ADP
bioscience-245	46	40	stress	stress	NOUN
bioscience-245	46	41	and	and	CCONJ
bioscience-245	46	42	anxiety	anxiety	NOUN
bioscience-245	46	43	[	[	X
bioscience-245	46	44	16	16	NUM
bioscience-245	46	45	;	;	PUNCT
bioscience-245	46	46	17	17	NUM
bioscience-245	46	47	]	]	PUNCT
bioscience-245	46	48	.	.	PUNCT
bioscience-245	47	1	importantly	importantly	ADV
bioscience-245	47	2	,	,	PUNCT
bioscience-245	47	3	l	l	NOUN
bioscience-245	47	4	-	-	NOUN
bioscience-245	47	5	arginine	arginine	NOUN
bioscience-245	47	6	has	have	AUX
bioscience-245	47	7	also	also	ADV
bioscience-245	47	8	been	be	AUX
bioscience-245	47	9	reported	report	VERB
bioscience-245	47	10	to	to	PART
bioscience-245	47	11	exhibit	exhibit	VERB
bioscience-245	47	12	antioxidant	antioxidant	ADJ
bioscience-245	47	13	properties	property	NOUN
bioscience-245	47	14	[	[	X
bioscience-245	47	15	18	18	NUM
bioscience-245	47	16	;	;	PUNCT
bioscience-245	47	17	19	19	NUM
bioscience-245	47	18	]	]	PUNCT
bioscience-245	47	19	.	.	PUNCT
bioscience-245	48	1	it	it	PRON
bioscience-245	48	2	downregulates	downregulate	VERB
bioscience-245	48	3	oxidative	oxidative	ADJ
bioscience-245	48	4	stress	stress	NOUN
bioscience-245	48	5	,	,	PUNCT
bioscience-245	48	6	at	at	ADP
bioscience-245	48	7	least	least	ADJ
bioscience-245	48	8	in	in	ADP
bioscience-245	48	9	part	part	NOUN
bioscience-245	48	10	,	,	PUNCT
bioscience-245	48	11	by	by	ADP
bioscience-245	48	12	enhancing	enhance	VERB
bioscience-245	48	13	the	the	DET
bioscience-245	48	14	antioxidant	antioxidant	ADJ
bioscience-245	48	15	system	system	NOUN
bioscience-245	48	16	through	through	ADP
bioscience-245	48	17	upregulation	upregulation	NOUN
bioscience-245	48	18	of	of	ADP
bioscience-245	48	19	related	related	ADJ
bioscience-245	48	20	enzymes	enzyme	NOUN
bioscience-245	48	21	.	.	PUNCT
bioscience-245	49	1	for	for	ADP
bioscience-245	49	2	example	example	NOUN
bioscience-245	49	3	:	:	PUNCT
bioscience-245	49	4	l	l	NOUN
bioscience-245	49	5	-	-	NOUN
bioscience-245	49	6	arginine	arginine	NOUN
bioscience-245	49	7	has	have	AUX
bioscience-245	49	8	been	be	AUX
bioscience-245	49	9	shown	show	VERB
bioscience-245	49	10	to	to	PART
bioscience-245	49	11	stimulate	stimulate	VERB
bioscience-245	49	12	glutathione	glutathione	NOUN
bioscience-245	49	13	synthesis	synthesis	NOUN
bioscience-245	49	14	and	and	CCONJ
bioscience-245	49	15	activate	activate	VERB
bioscience-245	49	16	the	the	DET
bioscience-245	49	17	nrf2	nrf2	NOUN
bioscience-245	49	18	pathway	pathway	NOUN
bioscience-245	49	19	,	,	PUNCT
bioscience-245	49	20	contributing	contribute	VERB
bioscience-245	49	21	to	to	ADP
bioscience-245	49	22	a	a	DET
bioscience-245	49	23	robust	robust	ADJ
bioscience-245	49	24	antioxidant	antioxidant	ADJ
bioscience-245	49	25	response	response	NOUN
bioscience-245	50	1	[	[	X
bioscience-245	50	2	20	20	NUM
bioscience-245	50	3	]	]	PUNCT
bioscience-245	50	4	.	.	PUNCT
bioscience-245	51	1	based	base	VERB
bioscience-245	51	2	on	on	ADP
bioscience-245	51	3	this	this	DET
bioscience-245	51	4	background	background	NOUN
bioscience-245	51	5	,	,	PUNCT
bioscience-245	51	6	the	the	DET
bioscience-245	51	7	present	present	ADJ
bioscience-245	51	8	study	study	NOUN
bioscience-245	51	9	aimed	aim	VERB
bioscience-245	51	10	to	to	PART
bioscience-245	51	11	investigate	investigate	VERB
bioscience-245	51	12	the	the	DET
bioscience-245	51	13	effects	effect	NOUN
bioscience-245	51	14	of	of	ADP
bioscience-245	51	15	exogenous	exogenous	ADJ
bioscience-245	51	16	l	l	NOUN
bioscience-245	51	17	-	-	NOUN
bioscience-245	51	18	arginine	arginine	NOUN
bioscience-245	51	19	on	on	ADP
bioscience-245	51	20	depressive	depressive	ADJ
bioscience-245	51	21	-	-	PUNCT
bioscience-245	51	22	like	like	ADJ
bioscience-245	51	23	behaviors	behavior	NOUN
bioscience-245	51	24	in	in	ADP
bioscience-245	51	25	a	a	DET
bioscience-245	51	26	rat	rat	NOUN
bioscience-245	51	27	model	model	NOUN
bioscience-245	51	28	,	,	PUNCT
bioscience-245	51	29	to	to	PART
bioscience-245	51	30	evaluate	evaluate	VERB
bioscience-245	51	31	its	its	PRON
bioscience-245	51	32	potential	potential	ADJ
bioscience-245	51	33	antidepressant	antidepressant	ADJ
bioscience-245	51	34	activity	activity	NOUN
bioscience-245	51	35	,	,	PUNCT
bioscience-245	51	36	and	and	CCONJ
bioscience-245	51	37	to	to	PART
bioscience-245	51	38	elucidate	elucidate	VERB
bioscience-245	51	39	the	the	DET
bioscience-245	51	40	molecular	molecular	ADJ
bioscience-245	51	41	mechanisms	mechanism	NOUN
bioscience-245	51	42	underlying	underlie	VERB
bioscience-245	51	43	its	its	PRON
bioscience-245	51	44	action	action	NOUN
bioscience-245	51	45	.	.	PUNCT
bioscience-245	52	1	materials	material	NOUN
bioscience-245	52	2	and	and	CCONJ
bioscience-245	52	3	methods	method	NOUN
bioscience-245	52	4	ethics	ethic	NOUN
bioscience-245	52	5	approval	approval	VERB
bioscience-245	52	6	the	the	DET
bioscience-245	52	7	study	study	NOUN
bioscience-245	52	8	protocol	protocol	NOUN
bioscience-245	52	9	was	be	AUX
bioscience-245	52	10	approved	approve	VERB
bioscience-245	52	11	by	by	ADP
bioscience-245	52	12	the	the	DET
bioscience-245	52	13	institutional	institutional	ADJ
bioscience-245	52	14	review	review	PROPN
bioscience-245	52	15	board	board	NOUN
bioscience-245	52	16	of	of	ADP
bioscience-245	52	17	ivane	ivane	NOUN
bioscience-245	52	18	javakhishvili	javakhishvili	NOUN
bioscience-245	52	19	tbilisi	tbilisi	PROPN
bioscience-245	52	20	state	state	PROPN
bioscience-245	52	21	university	university	PROPN
bioscience-245	52	22	.	.	PUNCT
bioscience-245	53	1	all	all	DET
bioscience-245	53	2	procefigure	procefigure	NOUN
bioscience-245	53	3	2	2	NUM
bioscience-245	53	4	.	.	PUNCT
bioscience-245	53	5	study	study	NOUN
bioscience-245	53	6	of	of	ADP
bioscience-245	53	7	corticosterone	corticosterone	NOUN
bioscience-245	53	8	-	-	PUNCT
bioscience-245	53	9	induced	induce	VERB
bioscience-245	53	10	depressive	depressive	ADJ
bioscience-245	53	11	state	state	NOUN
bioscience-245	53	12	in	in	ADP
bioscience-245	53	13	rats	rat	NOUN
bioscience-245	53	14	using	use	VERB
bioscience-245	53	15	the	the	DET
bioscience-245	53	16	free	free	ADJ
bioscience-245	53	17	swim	swim	NOUN
bioscience-245	53	18	test	test	NOUN
bioscience-245	53	19	(	(	PUNCT
bioscience-245	53	20	fst	fst	NOUN
bioscience-245	53	21	)	)	PUNCT
bioscience-245	53	22	and	and	CCONJ
bioscience-245	53	23	tail	tail	NOUN
bioscience-245	53	24	-	-	PUNCT
bioscience-245	53	25	flick	flick	NOUN
bioscience-245	53	26	test	test	NOUN
bioscience-245	53	27	(	(	PUNCT
bioscience-245	53	28	tst	tst	NOUN
bioscience-245	53	29	)	)	PUNCT
bioscience-245	53	30	.	.	PUNCT
bioscience-245	54	1	dures	dures	PROPN
bioscience-245	54	2	were	be	AUX
bioscience-245	54	3	conducted	conduct	VERB
bioscience-245	54	4	in	in	ADP
bioscience-245	54	5	accordance	accordance	NOUN
bioscience-245	54	6	with	with	ADP
bioscience-245	54	7	the	the	DET
bioscience-245	54	8	guidelines	guideline	NOUN
bioscience-245	54	9	for	for	ADP
bioscience-245	54	10	the	the	DET
bioscience-245	54	11	care	care	NOUN
bioscience-245	54	12	and	and	CCONJ
bioscience-245	54	13	use	use	NOUN
bioscience-245	54	14	of	of	ADP
bioscience-245	54	15	laboratory	laboratory	NOUN
bioscience-245	54	16	animals	animal	NOUN
bioscience-245	54	17	(	(	PUNCT
bioscience-245	54	18	n58/187	n58/187	NUM
bioscience-245	54	19	)	)	PUNCT
bioscience-245	54	20	.	.	PUNCT
bioscience-245	55	1	the	the	DET
bioscience-245	55	2	experimental	experimental	ADJ
bioscience-245	55	3	work	work	NOUN
bioscience-245	55	4	was	be	AUX
bioscience-245	55	5	performed	perform	VERB
bioscience-245	55	6	at	at	ADP
bioscience-245	55	7	the	the	DET
bioscience-245	55	8	department	department	NOUN
bioscience-245	55	9	of	of	ADP
bioscience-245	55	10	biology	biology	NOUN
bioscience-245	55	11	,	,	PUNCT
bioscience-245	55	12	faculty	faculty	NOUN
bioscience-245	55	13	of	of	ADP
bioscience-245	55	14	exact	exact	ADJ
bioscience-245	55	15	and	and	CCONJ
bioscience-245	55	16	natural	natural	ADJ
bioscience-245	55	17	sciences	science	NOUN
bioscience-245	55	18	,	,	PUNCT
bioscience-245	55	19	in	in	ADP
bioscience-245	55	20	close	close	ADJ
bioscience-245	55	21	collaboration	collaboration	NOUN
bioscience-245	55	22	with	with	ADP
bioscience-245	55	23	the	the	DET
bioscience-245	55	24	chair	chair	NOUN
bioscience-245	55	25	of	of	ADP
bioscience-245	55	26	biochemistry	biochemistry	NOUN
bioscience-245	55	27	.	.	PUNCT
bioscience-245	56	1	animals	animal	NOUN
bioscience-245	56	2	and	and	CCONJ
bioscience-245	56	3	housing	housing	NOUN
bioscience-245	56	4	conditions	condition	NOUN
bioscience-245	56	5	adult	adult	NOUN
bioscience-245	56	6	male	male	ADJ
bioscience-245	56	7	white	white	ADJ
bioscience-245	56	8	laboratory	laboratory	NOUN
bioscience-245	56	9	rats	rat	NOUN
bioscience-245	56	10	(	(	PUNCT
bioscience-245	56	11	weighing	weigh	VERB
bioscience-245	56	12	100	100	NUM
bioscience-245	56	13	±	±	NUM
bioscience-245	56	14	15	15	NUM
bioscience-245	56	15	g	g	NOUN
bioscience-245	56	16	)	)	PUNCT
bioscience-245	56	17	were	be	AUX
bioscience-245	56	18	obtained	obtain	VERB
bioscience-245	56	19	from	from	ADP
bioscience-245	56	20	the	the	DET
bioscience-245	56	21	animal	animal	NOUN
bioscience-245	56	22	facility	facility	NOUN
bioscience-245	56	23	of	of	ADP
bioscience-245	56	24	the	the	DET
bioscience-245	56	25	a.	a.	PROPN
bioscience-245	56	26	natishvili	natishvili	PROPN
bioscience-245	56	27	institute	institute	PROPN
bioscience-245	56	28	of	of	ADP
bioscience-245	56	29	morphology	morphology	PROPN
bioscience-245	56	30	,	,	PUNCT
bioscience-245	56	31	tbilisi	tbilisi	PROPN
bioscience-245	56	32	state	state	PROPN
bioscience-245	56	33	university	university	PROPN
bioscience-245	56	34	(	(	PUNCT
bioscience-245	56	35	tbilisi	tbilisi	PROPN
bioscience-245	56	36	,	,	PUNCT
bioscience-245	56	37	georgia	georgia	PROPN
bioscience-245	56	38	)	)	PUNCT
bioscience-245	56	39	.	.	PUNCT
bioscience-245	57	1	prior	prior	ADV
bioscience-245	57	2	to	to	ADP
bioscience-245	57	3	the	the	DET
bioscience-245	57	4	experiment	experiment	NOUN
bioscience-245	57	5	,	,	PUNCT
bioscience-245	57	6	the	the	DET
bioscience-245	57	7	rats	rat	NOUN
bioscience-245	57	8	underwent	undergo	VERB
bioscience-245	57	9	a	a	DET
bioscience-245	57	10	7	7	NUM
bioscience-245	57	11	-	-	PUNCT
bioscience-245	57	12	day	day	NOUN
bioscience-245	57	13	acclimatization	acclimatization	NOUN
bioscience-245	57	14	period	period	NOUN
bioscience-245	57	15	to	to	ADP
bioscience-245	57	16	the	the	DET
bioscience-245	57	17	vivarium	vivarium	NOUN
bioscience-245	57	18	conditions	condition	NOUN
bioscience-245	57	19	.	.	PUNCT
bioscience-245	58	1	animals	animal	NOUN
bioscience-245	58	2	were	be	AUX
bioscience-245	58	3	housed	house	VERB
bioscience-245	58	4	under	under	ADP
bioscience-245	58	5	standard	standard	ADJ
bioscience-245	58	6	laboratory	laboratory	NOUN
bioscience-245	58	7	conditions	condition	NOUN
bioscience-245	58	8	:	:	PUNCT
bioscience-245	58	9	a	a	DET
bioscience-245	58	10	12	12	NUM
bioscience-245	58	11	h	h	NOUN
bioscience-245	58	12	light	light	ADJ
bioscience-245	58	13	/	/	SYM
bioscience-245	58	14	dark	dark	ADJ
bioscience-245	58	15	cycle	cycle	NOUN
bioscience-245	58	16	,	,	PUNCT
bioscience-245	58	17	ambient	ambient	ADJ
bioscience-245	58	18	temperature	temperature	NOUN
bioscience-245	58	19	of	of	ADP
bioscience-245	58	20	22	22	NUM
bioscience-245	58	21	±	±	NUM
bioscience-245	58	22	1	1	NUM
bioscience-245	58	23	◦	◦	NOUN
bioscience-245	58	24	c	c	NOUN
bioscience-245	58	25	,	,	PUNCT
bioscience-245	58	26	and	and	CCONJ
bioscience-245	58	27	relative	relative	ADJ
bioscience-245	58	28	humidity	humidity	NOUN
bioscience-245	58	29	of	of	ADP
bioscience-245	58	30	47	47	NUM
bioscience-245	58	31	±	±	NUM
bioscience-245	58	32	2	2	NUM
bioscience-245	58	33	%	%	NOUN
bioscience-245	58	34	.	.	PUNCT
bioscience-245	59	1	food	food	NOUN
bioscience-245	59	2	and	and	CCONJ
bioscience-245	59	3	water	water	NOUN
bioscience-245	59	4	were	be	AUX
bioscience-245	59	5	provided	provide	VERB
bioscience-245	59	6	ad	ad	NOUN
bioscience-245	59	7	libitum	libitum	NOUN
bioscience-245	59	8	.	.	PUNCT
bioscience-245	60	1	the	the	DET
bioscience-245	60	2	animals	animal	NOUN
bioscience-245	60	3	were	be	AUX
bioscience-245	60	4	randomly	randomly	ADV
bioscience-245	60	5	assigned	assign	VERB
bioscience-245	60	6	to	to	ADP
bioscience-245	60	7	four	four	NUM
bioscience-245	60	8	experimental	experimental	ADJ
bioscience-245	60	9	groups	group	NOUN
bioscience-245	60	10	(	(	PUNCT
bioscience-245	60	11	n	n	NOUN
bioscience-245	60	12	=	=	SYM
bioscience-245	60	13	15	15	NUM
bioscience-245	60	14	per	per	ADP
bioscience-245	60	15	group	group	NOUN
bioscience-245	60	16	;	;	PUNCT
bioscience-245	60	17	figure	figure	NOUN
bioscience-245	60	18	1	1	NUM
bioscience-245	60	19	):	):	PUNCT
bioscience-245	60	20	•	•	NUM
bioscience-245	60	21	group	group	NOUN
bioscience-245	60	22	i	i	PRON
bioscience-245	60	23	(	(	PUNCT
bioscience-245	60	24	g1	g1	PROPN
bioscience-245	60	25	)	)	PUNCT
bioscience-245	60	26	received	receive	VERB
bioscience-245	60	27	daily	daily	ADJ
bioscience-245	60	28	intraperitoneal	intraperitoneal	ADJ
bioscience-245	60	29	injections	injection	NOUN
bioscience-245	60	30	of	of	ADP
bioscience-245	60	31	100	100	NUM
bioscience-245	60	32	µl	µl	PART
bioscience-245	60	33	100	100	NUM
bioscience-245	60	34	%	%	NOUN
bioscience-245	60	35	dimethyl	dimethyl	NOUN
bioscience-245	60	36	sulfoxide	sulfoxide	NOUN
bioscience-245	60	37	(	(	PUNCT
bioscience-245	60	38	dmso	dmso	PROPN
bioscience-245	60	39	)	)	PUNCT
bioscience-245	60	40	(	(	PUNCT
bioscience-245	60	41	sc-358801	sc-358801	PROPN
bioscience-245	60	42	,	,	PUNCT
bioscience-245	60	43	santa	santa	PROPN
bioscience-245	60	44	cruz	cruz	PROPN
bioscience-245	60	45	biotechnology	biotechnology	PROPN
bioscience-245	60	46	,	,	PUNCT
bioscience-245	60	47	inc	inc	PROPN
bioscience-245	60	48	.	.	PROPN
bioscience-245	60	49	,	,	PUNCT
bioscience-245	60	50	europe	europe	PROPN
bioscience-245	60	51	)	)	PUNCT
bioscience-245	60	52	for	for	ADP
bioscience-245	60	53	14	14	NUM
bioscience-245	60	54	consecutive	consecutive	ADJ
bioscience-245	60	55	days	day	NOUN
bioscience-245	60	56	and	and	CCONJ
bioscience-245	60	57	served	serve	VERB
bioscience-245	60	58	as	as	ADP
bioscience-245	60	59	the	the	DET
bioscience-245	60	60	vehicle	vehicle	NOUN
bioscience-245	60	61	control	control	PROPN
bioscience-245	60	62	group	group	PROPN
bioscience-245	60	63	.	.	PUNCT
bioscience-245	61	1	•	•	PROPN
bioscience-245	61	2	group	group	PROPN
bioscience-245	61	3	ii	ii	PROPN
bioscience-245	61	4	(	(	PUNCT
bioscience-245	61	5	g2	g2	PROPN
bioscience-245	61	6	)	)	PUNCT
bioscience-245	61	7	received	receive	VERB
bioscience-245	61	8	daily	daily	ADJ
bioscience-245	61	9	intraperitoneal	intraperitoneal	ADJ
bioscience-245	61	10	injections	injection	NOUN
bioscience-245	61	11	of	of	ADP
bioscience-245	61	12	corticosterone	corticosterone	NOUN
bioscience-245	61	13	(	(	PUNCT
bioscience-245	61	14	20	20	NUM
bioscience-245	61	15	mg	mg	NUM
bioscience-245	61	16	/	/	SYM
bioscience-245	61	17	kg	kg	NOUN
bioscience-245	61	18	)	)	PUNCT
bioscience-245	61	19	(	(	PUNCT
bioscience-245	61	20	sc-300391	sc-300391	PROPN
bioscience-245	61	21	,	,	PUNCT
bioscience-245	61	22	santa	santa	PROPN
bioscience-245	61	23	cruz	cruz	PROPN
bioscience-245	61	24	biotechnology	biotechnology	PROPN
bioscience-245	61	25	,	,	PUNCT
bioscience-245	61	26	inc	inc	PROPN
bioscience-245	61	27	.	.	PROPN
bioscience-245	61	28	,	,	PUNCT
bioscience-245	61	29	europe	europe	PROPN
bioscience-245	61	30	)	)	PUNCT
bioscience-245	61	31	for	for	ADP
bioscience-245	61	32	14	14	NUM
bioscience-245	61	33	consecutive	consecutive	ADJ
bioscience-245	61	34	days	day	NOUN
bioscience-245	61	35	to	to	PART
bioscience-245	61	36	induce	induce	VERB
bioscience-245	61	37	depressive	depressive	ADJ
bioscience-245	61	38	-	-	PUNCT
bioscience-245	61	39	like	like	ADJ
bioscience-245	61	40	behavior	behavior	NOUN
bioscience-245	61	41	.	.	PUNCT
bioscience-245	62	1	•	•	NUM
bioscience-245	62	2	group	group	PROPN
bioscience-245	62	3	iii	iii	PROPN
bioscience-245	62	4	(	(	PUNCT
bioscience-245	62	5	g3	g3	NOUN
bioscience-245	62	6	)	)	PUNCT
bioscience-245	62	7	received	receive	VERB
bioscience-245	62	8	corticosterone	corticosterone	NOUN
bioscience-245	62	9	as	as	SCONJ
bioscience-245	62	10	described	describe	VERB
bioscience-245	62	11	for	for	ADP
bioscience-245	62	12	g2	g2	PROPN
bioscience-245	62	13	during	during	ADP
bioscience-245	62	14	the	the	DET
bioscience-245	62	15	first	first	ADJ
bioscience-245	62	16	14	14	NUM
bioscience-245	62	17	days	day	NOUN
bioscience-245	62	18	,	,	PUNCT
bioscience-245	62	19	followed	follow	VERB
bioscience-245	62	20	by	by	ADP
bioscience-245	62	21	daily	daily	ADJ
bioscience-245	62	22	oral	oral	ADJ
bioscience-245	62	23	administration	administration	NOUN
bioscience-245	62	24	of	of	ADP
bioscience-245	62	25	l	l	NOUN
bioscience-245	62	26	-	-	NOUN
bioscience-245	62	27	arginine	arginine	NOUN
bioscience-245	62	28	(	(	PUNCT
bioscience-245	62	29	150	150	NUM
bioscience-245	62	30	mg	mg	NUM
bioscience-245	62	31	/	/	SYM
bioscience-245	62	32	kg	kg	NOUN
bioscience-245	62	33	)	)	PUNCT
bioscience-245	62	34	(	(	PUNCT
bioscience-245	62	35	sc-391662	sc-391662	PROPN
bioscience-245	62	36	,	,	PUNCT
bioscience-245	62	37	santa	santa	PROPN
bioscience-245	62	38	cruz	cruz	PROPN
bioscience-245	62	39	biotechnology	biotechnology	PROPN
bioscience-245	62	40	,	,	PUNCT
bioscience-245	62	41	inc	inc	PROPN
bioscience-245	62	42	.	.	PROPN
bioscience-245	62	43	,	,	PUNCT
bioscience-245	62	44	europe	europe	PROPN
bioscience-245	62	45	)	)	PUNCT
bioscience-245	62	46	for	for	ADP
bioscience-245	62	47	an	an	DET
bioscience-245	62	48	additional	additional	ADJ
bioscience-245	62	49	14	14	NUM
bioscience-245	62	50	days	day	NOUN
bioscience-245	62	51	.	.	PUNCT
bioscience-245	63	1	•	•	NUM
bioscience-245	63	2	group	group	NOUN
bioscience-245	63	3	iv	iv	NUM
bioscience-245	63	4	(	(	PUNCT
bioscience-245	63	5	g4	g4	NOUN
bioscience-245	63	6	)	)	PUNCT
bioscience-245	63	7	received	receive	VERB
bioscience-245	63	8	corticosterone	corticosterone	NOUN
bioscience-245	63	9	as	as	SCONJ
bioscience-245	63	10	described	describe	VERB
bioscience-245	63	11	for	for	ADP
bioscience-245	63	12	g2	g2	PROPN
bioscience-245	63	13	during	during	ADP
bioscience-245	63	14	the	the	DET
bioscience-245	63	15	first	first	ADJ
bioscience-245	63	16	14	14	NUM
bioscience-245	63	17	days	day	NOUN
bioscience-245	63	18	,	,	PUNCT
bioscience-245	63	19	followed	follow	VERB
bioscience-245	63	20	by	by	ADP
bioscience-245	63	21	daily	daily	ADJ
bioscience-245	63	22	oral	oral	ADJ
bioscience-245	63	23	administration	administration	NOUN
bioscience-245	63	24	of	of	ADP
bioscience-245	63	25	fluoxetine	fluoxetine	NOUN
bioscience-245	63	26	(	(	PUNCT
bioscience-245	63	27	10	10	NUM
bioscience-245	63	28	mg	mg	NUM
bioscience-245	63	29	/	/	SYM
bioscience-245	63	30	kg	kg	NOUN
bioscience-245	63	31	)	)	PUNCT
bioscience-245	63	32	(	(	PUNCT
bioscience-245	63	33	sc-279166	sc-279166	PROPN
bioscience-245	63	34	,	,	PUNCT
bioscience-245	63	35	santa	santa	PROPN
bioscience-245	63	36	cruz	cruz	PROPN
bioscience-245	63	37	biotechnology	biotechnology	PROPN
bioscience-245	63	38	,	,	PUNCT
bioscience-245	63	39	inc	inc	PROPN
bioscience-245	63	40	.	.	PROPN
bioscience-245	63	41	,	,	PUNCT
bioscience-245	63	42	europe	europe	PROPN
bioscience-245	63	43	)	)	PUNCT
bioscience-245	63	44	for	for	ADP
bioscience-245	63	45	the	the	DET
bioscience-245	63	46	next	next	ADJ
bioscience-245	63	47	14	14	NUM
bioscience-245	63	48	days	day	NOUN
bioscience-245	63	49	.	.	PUNCT
bioscience-245	64	1	behavioral	behavioral	ADJ
bioscience-245	64	2	assessments	assessment	NOUN
bioscience-245	64	3	and	and	CCONJ
bioscience-245	64	4	biochemical	biochemical	ADJ
bioscience-245	64	5	analysis	analysis	NOUN
bioscience-245	64	6	to	to	PART
bioscience-245	64	7	assess	assess	VERB
bioscience-245	64	8	the	the	DET
bioscience-245	64	9	emotional	emotional	ADJ
bioscience-245	64	10	state	state	NOUN
bioscience-245	64	11	and	and	CCONJ
bioscience-245	64	12	depression	depression	NOUN
bioscience-245	64	13	-	-	PUNCT
bioscience-245	64	14	like	like	ADJ
bioscience-245	64	15	behavior	behavior	NOUN
bioscience-245	64	16	of	of	ADP
bioscience-245	64	17	the	the	DET
bioscience-245	64	18	experimental	experimental	ADJ
bioscience-245	64	19	animals	animal	NOUN
bioscience-245	64	20	,	,	PUNCT
bioscience-245	64	21	the	the	DET
bioscience-245	64	22	open	open	ADJ
bioscience-245	64	23	-	-	PUNCT
bioscience-245	64	24	field	field	NOUN
bioscience-245	64	25	test	test	NOUN
bioscience-245	64	26	(	(	PUNCT
bioscience-245	64	27	oft	oft	ADV
bioscience-245	64	28	)	)	PUNCT
bioscience-245	64	29	,	,	PUNCT
bioscience-245	64	30	forced	force	VERB
bioscience-245	64	31	highlights	highlight	NOUN
bioscience-245	64	32	in	in	ADP
bioscience-245	64	33	bioscience	bioscience	NOUN
bioscience-245	64	34	page	page	NOUN
bioscience-245	64	35	2	2	NUM
bioscience-245	64	36	of	of	ADP
bioscience-245	64	37	7	7	NUM
bioscience-245	64	38	june	june	PROPN
bioscience-245	64	39	2025|volume	2025|volume	NUM
bioscience-245	64	40	8	8	NUM
bioscience-245	64	41	http://bioscience.highlightsin.org/	http://bioscience.highlightsin.org/	NOUN
bioscience-245	64	42	mantashashvili	mantashashvili	NOUN
bioscience-245	65	1	t	t	PROPN
bioscience-245	65	2	et	et	PROPN
bioscience-245	65	3	al	al	PROPN
bioscience-245	65	4	.	.	PROPN
bioscience-245	65	5	,	,	PUNCT
bioscience-245	65	6	2025	2025	NUM
bioscience-245	65	7	l	l	NOUN
bioscience-245	65	8	-	-	NOUN
bioscience-245	65	9	arginine	arginine	NOUN
bioscience-245	65	10	as	as	ADP
bioscience-245	65	11	a	a	DET
bioscience-245	65	12	potential	potential	ADJ
bioscience-245	65	13	antidepressant	antidepressant	NOUN
bioscience-245	65	14	:	:	PUNCT
bioscience-245	65	15	effects	effect	NOUN
bioscience-245	65	16	on	on	ADP
bioscience-245	65	17	cognitive	cognitive	ADJ
bioscience-245	65	18	function	function	NOUN
bioscience-245	65	19	table	table	NOUN
bioscience-245	65	20	1	1	NUM
bioscience-245	65	21	.	.	PUNCT
bioscience-245	66	1	changes	change	NOUN
bioscience-245	66	2	in	in	ADP
bioscience-245	66	3	some	some	DET
bioscience-245	66	4	physiological	physiological	ADJ
bioscience-245	66	5	parameters	parameter	NOUN
bioscience-245	66	6	of	of	ADP
bioscience-245	66	7	experimental	experimental	ADJ
bioscience-245	66	8	animals	animal	NOUN
bioscience-245	66	9	under	under	ADP
bioscience-245	66	10	the	the	DET
bioscience-245	66	11	influence	influence	NOUN
bioscience-245	66	12	of	of	ADP
bioscience-245	66	13	dietary	dietary	ADJ
bioscience-245	66	14	l	l	NOUN
bioscience-245	66	15	-	-	NOUN
bioscience-245	66	16	arginine	arginine	NOUN
bioscience-245	66	17	under	under	ADP
bioscience-245	66	18	conditions	condition	NOUN
bioscience-245	66	19	of	of	ADP
bioscience-245	66	20	corticosterone	corticosterone	NOUN
bioscience-245	66	21	-	-	PUNCT
bioscience-245	66	22	induced	induce	VERB
bioscience-245	66	23	depression	depression	NOUN
bioscience-245	66	24	.	.	PUNCT
bioscience-245	67	1	behavioural	behavioural	ADJ
bioscience-245	67	2	parameters	parameter	NOUN
bioscience-245	67	3	i	i	PROPN
bioscience-245	67	4	group	group	PROPN
bioscience-245	67	5	ii	ii	PROPN
bioscience-245	67	6	group	group	PROPN
bioscience-245	67	7	iii	iii	PROPN
bioscience-245	67	8	group	group	PROPN
bioscience-245	67	9	iv	iv	NUM
bioscience-245	67	10	group	group	NOUN
bioscience-245	67	11	crossed	cross	VERB
bioscience-245	67	12	cells	cell	NOUN
bioscience-245	67	13	255.5	255.5	NUM
bioscience-245	67	14	±	±	NUM
bioscience-245	67	15	15.5	15.5	NUM
bioscience-245	67	16	73.7	73.7	NUM
bioscience-245	67	17	±	±	NUM
bioscience-245	67	18	18.7∗	18.7∗	NUM
bioscience-245	67	19	280.57	280.57	NUM
bioscience-245	67	20	±	±	NUM
bioscience-245	67	21	20.8	20.8	NUM
bioscience-245	67	22	#	#	SYM
bioscience-245	67	23	#	#	NOUN
bioscience-245	67	24	270.97	270.97	NUM
bioscience-245	67	25	±	±	NUM
bioscience-245	67	26	22.4	22.4	NUM
bioscience-245	67	27	#	#	SYM
bioscience-245	67	28	#	#	NOUN
bioscience-245	67	29	#	#	NOUN
bioscience-245	67	30	number	number	NOUN
bioscience-245	67	31	of	of	ADP
bioscience-245	67	32	positions	position	NOUN
bioscience-245	67	33	in	in	ADP
bioscience-245	67	34	the	the	DET
bioscience-245	67	35	centre	centre	NOUN
bioscience-245	67	36	2.89	2.89	NUM
bioscience-245	67	37	±	±	NUM
bioscience-245	67	38	0.5	0.5	NUM
bioscience-245	67	39	0.4	0.4	NUM
bioscience-245	67	40	±	±	NOUN
bioscience-245	67	41	0.1∗∗	0.1∗∗	NOUN
bioscience-245	67	42	2.757	2.757	NUM
bioscience-245	67	43	±	±	NUM
bioscience-245	68	1	0.8	0.8	NUM
bioscience-245	68	2	#	#	SYM
bioscience-245	68	3	#	#	SYM
bioscience-245	68	4	#	#	NOUN
bioscience-245	68	5	2.607	2.607	NUM
bioscience-245	68	6	±	±	NUM
bioscience-245	68	7	0.3	0.3	NUM
bioscience-245	68	8	#	#	SYM
bioscience-245	68	9	#	#	SYM
bioscience-245	68	10	#	#	NOUN
bioscience-245	68	11	vertical	vertical	ADJ
bioscience-245	68	12	posture	posture	NOUN
bioscience-245	68	13	3.97	3.97	NUM
bioscience-245	68	14	±	±	NUM
bioscience-245	68	15	0.7	0.7	NUM
bioscience-245	68	16	0.5	0.5	NUM
bioscience-245	68	17	±	±	NOUN
bioscience-245	68	18	0.1∗∗∗	0.1∗∗∗	NOUN
bioscience-245	68	19	6.97	6.97	NUM
bioscience-245	68	20	±	±	NUM
bioscience-245	68	21	2.5	2.5	NUM
bioscience-245	68	22	#	#	SYM
bioscience-245	68	23	#	#	SYM
bioscience-245	68	24	#	#	NOUN
bioscience-245	68	25	5.557	5.557	NUM
bioscience-245	68	26	±	±	NUM
bioscience-245	68	27	1.9	1.9	NUM
bioscience-245	68	28	#	#	SYM
bioscience-245	68	29	#	#	SYM
bioscience-245	68	30	#	#	NOUN
bioscience-245	68	31	vertical	vertical	ADJ
bioscience-245	68	32	posture	posture	NOUN
bioscience-245	68	33	with	with	ADP
bioscience-245	68	34	wall	wall	NOUN
bioscience-245	68	35	touching	touch	VERB
bioscience-245	68	36	13.5	13.5	NUM
bioscience-245	68	37	±	±	NUM
bioscience-245	68	38	3.1	3.1	NUM
bioscience-245	68	39	6.9	6.9	NUM
bioscience-245	68	40	±	±	NUM
bioscience-245	68	41	1.1∗∗	1.1∗∗	NOUN
bioscience-245	68	42	1.8	1.8	NUM
bioscience-245	68	43	±	±	NUM
bioscience-245	69	1	0.3	0.3	NUM
bioscience-245	69	2	#	#	SYM
bioscience-245	69	3	#	#	SYM
bioscience-245	69	4	#	#	NOUN
bioscience-245	69	5	2.0	2.0	NUM
bioscience-245	69	6	±	±	NUM
bioscience-245	69	7	0.4	0.4	NUM
bioscience-245	69	8	#	#	SYM
bioscience-245	69	9	#	#	SYM
bioscience-245	69	10	#	#	NOUN
bioscience-245	69	11	duration	duration	NOUN
bioscience-245	69	12	of	of	ADP
bioscience-245	69	13	freezing	freezing	NOUN
bioscience-245	69	14	(	(	PUNCT
bioscience-245	69	15	sec	sec	PROPN
bioscience-245	69	16	)	)	PUNCT
bioscience-245	69	17	32.8	32.8	NUM
bioscience-245	69	18	±	±	NUM
bioscience-245	69	19	3.8	3.8	NUM
bioscience-245	69	20	127.7	127.7	NUM
bioscience-245	69	21	±	±	NUM
bioscience-245	69	22	12.4∗∗∗	12.4∗∗∗	NUM
bioscience-245	69	23	40.3	40.3	NUM
bioscience-245	69	24	±	±	NUM
bioscience-245	69	25	4.6	4.6	NUM
bioscience-245	69	26	#	#	SYM
bioscience-245	69	27	#	#	SYM
bioscience-245	69	28	#	#	NOUN
bioscience-245	69	29	38.8	38.8	NUM
bioscience-245	69	30	±	±	NUM
bioscience-245	69	31	5.2	5.2	NUM
bioscience-245	69	32	#	#	SYM
bioscience-245	69	33	#	#	SYM
bioscience-245	69	34	#	#	NOUN
bioscience-245	69	35	duration	duration	NOUN
bioscience-245	69	36	of	of	ADP
bioscience-245	69	37	grooming	groom	VERB
bioscience-245	69	38	(	(	PUNCT
bioscience-245	69	39	sec	sec	PROPN
bioscience-245	69	40	)	)	PUNCT
bioscience-245	69	41	18.9	18.9	NUM
bioscience-245	69	42	±	±	NUM
bioscience-245	69	43	3.5	3.5	NUM
bioscience-245	69	44	9.7	9.7	NUM
bioscience-245	69	45	±	±	NOUN
bioscience-245	69	46	2.9∗∗∗	2.9∗∗∗	NUM
bioscience-245	69	47	16.2	16.2	NUM
bioscience-245	69	48	±	±	NUM
bioscience-245	69	49	3.1	3.1	NUM
bioscience-245	69	50	#	#	SYM
bioscience-245	69	51	#	#	NOUN
bioscience-245	69	52	17.7	17.7	NUM
bioscience-245	69	53	±	±	NUM
bioscience-245	70	1	2.4	2.4	NUM
bioscience-245	70	2	#	#	SYM
bioscience-245	70	3	#	#	SYM
bioscience-245	70	4	#	#	NOUN
bioscience-245	70	5	defecation	defecation	NOUN
bioscience-245	70	6	2.5	2.5	NUM
bioscience-245	70	7	±	±	NUM
bioscience-245	70	8	0.4	0.4	NUM
bioscience-245	70	9	3.7	3.7	NUM
bioscience-245	70	10	±	±	NOUN
bioscience-245	70	11	0.9∗	0.9∗	NUM
bioscience-245	70	12	1.7	1.7	NUM
bioscience-245	70	13	±	±	NUM
bioscience-245	70	14	0.1	0.1	NUM
bioscience-245	70	15	#	#	NOUN
bioscience-245	70	16	2.3	2.3	NUM
bioscience-245	70	17	±	±	NUM
bioscience-245	70	18	0.1	0.1	NUM
bioscience-245	70	19	#	#	NOUN
bioscience-245	70	20	the	the	DET
bioscience-245	70	21	duration	duration	NOUN
bioscience-245	70	22	of	of	ADP
bioscience-245	70	23	immobility	immobility	NOUN
bioscience-245	70	24	in	in	ADP
bioscience-245	70	25	the	the	DET
bioscience-245	70	26	fst	fst	NOUN
bioscience-245	70	27	(	(	PUNCT
bioscience-245	70	28	sec	sec	PROPN
bioscience-245	70	29	)	)	PUNCT
bioscience-245	70	30	160.0	160.0	NUM
bioscience-245	70	31	±	±	NUM
bioscience-245	70	32	15.1	15.1	NUM
bioscience-245	70	33	210.6	210.6	NUM
bioscience-245	70	34	±	±	NOUN
bioscience-245	70	35	30.7∗∗	30.7∗∗	NUM
bioscience-245	70	36	100.5	100.5	NUM
bioscience-245	70	37	±	±	NUM
bioscience-245	70	38	15.5	15.5	NUM
bioscience-245	70	39	#	#	SYM
bioscience-245	70	40	#	#	NOUN
bioscience-245	70	41	140.9	140.9	NUM
bioscience-245	70	42	±	±	NUM
bioscience-245	70	43	30.8	30.8	NUM
bioscience-245	70	44	#	#	SYM
bioscience-245	70	45	#	#	NOUN
bioscience-245	70	46	the	the	DET
bioscience-245	70	47	duration	duration	NOUN
bioscience-245	70	48	of	of	ADP
bioscience-245	70	49	immobility	immobility	NOUN
bioscience-245	70	50	in	in	ADP
bioscience-245	70	51	the	the	DET
bioscience-245	70	52	tst	tst	NOUN
bioscience-245	70	53	(	(	PUNCT
bioscience-245	70	54	sec	sec	PROPN
bioscience-245	70	55	)	)	PUNCT
bioscience-245	70	56	50.5	50.5	NUM
bioscience-245	70	57	±	±	NUM
bioscience-245	70	58	9.6	9.6	NUM
bioscience-245	70	59	225.0	225.0	NUM
bioscience-245	70	60	±	±	NUM
bioscience-245	70	61	25.9∗∗∗	25.9∗∗∗	NOUN
bioscience-245	70	62	144.8	144.8	NUM
bioscience-245	70	63	±	±	NUM
bioscience-245	70	64	35.8	35.8	NUM
bioscience-245	70	65	#	#	SYM
bioscience-245	70	66	#	#	NOUN
bioscience-245	70	67	145.3	145.3	NUM
bioscience-245	70	68	±	±	NUM
bioscience-245	70	69	47.4	47.4	NUM
bioscience-245	70	70	#	#	SYM
bioscience-245	70	71	#	#	SYM
bioscience-245	70	72	#	#	NOUN
bioscience-245	70	73	data	datum	NOUN
bioscience-245	70	74	are	be	AUX
bioscience-245	70	75	shown	show	VERB
bioscience-245	70	76	as	as	ADP
bioscience-245	70	77	mean	mean	PROPN
bioscience-245	70	78	±	±	NUM
bioscience-245	70	79	sd	sd	NOUN
bioscience-245	70	80	;	;	PUNCT
bioscience-245	70	81	∗	∗	NOUN
bioscience-245	70	82	,	,	PUNCT
bioscience-245	70	83	the	the	DET
bioscience-245	70	84	difference	difference	NOUN
bioscience-245	70	85	compared	compare	VERB
bioscience-245	70	86	to	to	ADP
bioscience-245	70	87	control	control	NOUN
bioscience-245	70	88	;	;	PUNCT
bioscience-245	70	89	#	#	X
bioscience-245	70	90	,	,	PUNCT
bioscience-245	70	91	the	the	DET
bioscience-245	70	92	difference	difference	NOUN
bioscience-245	70	93	compared	compare	VERB
bioscience-245	70	94	to	to	ADP
bioscience-245	70	95	cort	cort	NOUN
bioscience-245	70	96	-	-	PUNCT
bioscience-245	70	97	induced	induce	VERB
bioscience-245	70	98	depression	depression	NOUN
bioscience-245	70	99	;	;	PUNCT
bioscience-245	70	100	∗	∗	NOUN
bioscience-245	70	101	,	,	PUNCT
bioscience-245	70	102	#	#	NOUN
bioscience-245	70	103	,	,	PUNCT
bioscience-245	70	104	p	p	X
bioscience-245	70	105	<	<	X
bioscience-245	70	106	0.05	0.05	NUM
bioscience-245	70	107	;	;	PUNCT
bioscience-245	70	108	∗∗	∗∗	NOUN
bioscience-245	70	109	,	,	PUNCT
bioscience-245	70	110	#	#	SYM
bioscience-245	70	111	#	#	NOUN
bioscience-245	70	112	,	,	PUNCT
bioscience-245	70	113	p	p	X
bioscience-245	70	114	<	<	X
bioscience-245	70	115	0.01	0.01	NUM
bioscience-245	70	116	;	;	PUNCT
bioscience-245	70	117	∗∗∗	∗∗∗	NUM
bioscience-245	70	118	,	,	PUNCT
bioscience-245	70	119	#	#	SYM
bioscience-245	70	120	#	#	SYM
bioscience-245	70	121	#	#	NOUN
bioscience-245	70	122	,	,	PUNCT
bioscience-245	70	123	p	p	X
bioscience-245	70	124	<	<	X
bioscience-245	70	125	0.001	0.001	NUM
bioscience-245	70	126	swim	swim	NOUN
bioscience-245	70	127	test	test	NOUN
bioscience-245	70	128	(	(	PUNCT
bioscience-245	70	129	fst	fst	NOUN
bioscience-245	70	130	)	)	PUNCT
bioscience-245	70	131	,	,	PUNCT
bioscience-245	70	132	and	and	CCONJ
bioscience-245	70	133	tail	tail	NOUN
bioscience-245	70	134	suspension	suspension	NOUN
bioscience-245	70	135	test	test	NOUN
bioscience-245	70	136	(	(	PUNCT
bioscience-245	70	137	tst	tst	NOUN
bioscience-245	70	138	)	)	PUNCT
bioscience-245	70	139	were	be	AUX
bioscience-245	70	140	performed	perform	VERB
bioscience-245	70	141	figure	figure	NOUN
bioscience-245	70	142	2	2	NUM
bioscience-245	70	143	.	.	PUNCT
bioscience-245	71	1	these	these	DET
bioscience-245	71	2	tests	test	NOUN
bioscience-245	71	3	were	be	AUX
bioscience-245	71	4	conducted	conduct	VERB
bioscience-245	71	5	in	in	ADP
bioscience-245	71	6	accordance	accordance	NOUN
bioscience-245	71	7	with	with	ADP
bioscience-245	71	8	the	the	DET
bioscience-245	71	9	methodology	methodology	NOUN
bioscience-245	71	10	described	describe	VERB
bioscience-245	71	11	by	by	ADP
bioscience-245	71	12	[	[	X
bioscience-245	71	13	15	15	NUM
bioscience-245	71	14	]	]	PUNCT
bioscience-245	71	15	.	.	PUNCT
bioscience-245	72	1	in	in	ADP
bioscience-245	72	2	the	the	DET
bioscience-245	72	3	fst	fst	NOUN
bioscience-245	72	4	,	,	PUNCT
bioscience-245	72	5	rats	rat	NOUN
bioscience-245	72	6	were	be	AUX
bioscience-245	72	7	placed	place	VERB
bioscience-245	72	8	in	in	ADP
bioscience-245	72	9	a	a	DET
bioscience-245	72	10	cylinder	cylinder	NOUN
bioscience-245	72	11	filled	fill	VERB
bioscience-245	72	12	with	with	ADP
bioscience-245	72	13	water	water	NOUN
bioscience-245	72	14	for	for	ADP
bioscience-245	72	15	a	a	DET
bioscience-245	72	16	total	total	ADJ
bioscience-245	72	17	duration	duration	NOUN
bioscience-245	72	18	of	of	ADP
bioscience-245	72	19	6	6	NUM
bioscience-245	72	20	minutes	minute	NOUN
bioscience-245	72	21	,	,	PUNCT
bioscience-245	72	22	while	while	SCONJ
bioscience-245	72	23	in	in	ADP
bioscience-245	72	24	the	the	DET
bioscience-245	72	25	tst	tst	NOUN
bioscience-245	72	26	,	,	PUNCT
bioscience-245	72	27	the	the	DET
bioscience-245	72	28	animals	animal	NOUN
bioscience-245	72	29	were	be	AUX
bioscience-245	72	30	suspended	suspend	VERB
bioscience-245	72	31	by	by	ADP
bioscience-245	72	32	the	the	DET
bioscience-245	72	33	tail	tail	NOUN
bioscience-245	72	34	for	for	ADP
bioscience-245	72	35	5	5	NUM
bioscience-245	72	36	minutes	minute	NOUN
bioscience-245	72	37	.	.	PUNCT
bioscience-245	73	1	a	a	DET
bioscience-245	73	2	corticosterone	corticosterone	NOUN
bioscience-245	73	3	solution	solution	NOUN
bioscience-245	73	4	(	(	PUNCT
bioscience-245	73	5	20	20	NUM
bioscience-245	73	6	mg	mg	NUM
bioscience-245	73	7	/	/	SYM
bioscience-245	73	8	ml	ml	NOUN
bioscience-245	73	9	)	)	PUNCT
bioscience-245	73	10	was	be	AUX
bioscience-245	73	11	freshly	freshly	ADV
bioscience-245	73	12	prepared	prepare	VERB
bioscience-245	73	13	each	each	DET
bioscience-245	73	14	day	day	NOUN
bioscience-245	73	15	in	in	ADP
bioscience-245	73	16	100	100	NUM
bioscience-245	73	17	%	%	NOUN
bioscience-245	73	18	dimethyl	dimethyl	NOUN
bioscience-245	73	19	sulfoxide	sulfoxide	NOUN
bioscience-245	73	20	(	(	PUNCT
bioscience-245	73	21	dmso	dmso	NOUN
bioscience-245	73	22	)	)	PUNCT
bioscience-245	73	23	and	and	CCONJ
bioscience-245	73	24	administered	administer	VERB
bioscience-245	73	25	intraperitoneally	intraperitoneally	ADV
bioscience-245	73	26	at	at	ADP
bioscience-245	73	27	a	a	DET
bioscience-245	73	28	dose	dose	NOUN
bioscience-245	73	29	of	of	ADP
bioscience-245	73	30	20	20	NUM
bioscience-245	73	31	mg	mg	PROPN
bioscience-245	73	32	/	/	SYM
bioscience-245	73	33	kg	kg	PROPN
bioscience-245	73	34	,	,	PUNCT
bioscience-245	73	35	as	as	SCONJ
bioscience-245	73	36	outlined	outline	VERB
bioscience-245	73	37	in	in	ADP
bioscience-245	73	38	figure	figure	NOUN
bioscience-245	73	39	1	1	NUM
bioscience-245	73	40	.	.	PUNCT
bioscience-245	74	1	the	the	DET
bioscience-245	74	2	concentrations	concentration	NOUN
bioscience-245	74	3	of	of	ADP
bioscience-245	74	4	nitric	nitric	ADJ
bioscience-245	74	5	oxide	oxide	NOUN
bioscience-245	74	6	(	(	PUNCT
bioscience-245	74	7	no	no	NOUN
bioscience-245	74	8	)	)	PUNCT
bioscience-245	74	9	and	and	CCONJ
bioscience-245	74	10	malondialdehyde	malondialdehyde	NOUN
bioscience-245	74	11	(	(	PUNCT
bioscience-245	74	12	mda	mda	PROPN
bioscience-245	74	13	)	)	PUNCT
bioscience-245	74	14	,	,	PUNCT
bioscience-245	74	15	along	along	ADP
bioscience-245	74	16	with	with	ADP
bioscience-245	74	17	the	the	DET
bioscience-245	74	18	enzymatic	enzymatic	ADJ
bioscience-245	74	19	activities	activity	NOUN
bioscience-245	74	20	of	of	ADP
bioscience-245	74	21	superoxide	superoxide	NOUN
bioscience-245	74	22	dismutase	dismutase	NOUN
bioscience-245	74	23	(	(	PUNCT
bioscience-245	74	24	sod	sod	NOUN
bioscience-245	74	25	)	)	PUNCT
bioscience-245	74	26	and	and	CCONJ
bioscience-245	74	27	catalase	catalase	NOUN
bioscience-245	74	28	,	,	PUNCT
bioscience-245	74	29	were	be	AUX
bioscience-245	74	30	measured	measure	VERB
bioscience-245	74	31	spectrophotometrically	spectrophotometrically	ADV
bioscience-245	74	32	following	follow	VERB
bioscience-245	74	33	previously	previously	ADV
bioscience-245	74	34	described	describe	VERB
bioscience-245	74	35	methods	method	NOUN
bioscience-245	74	36	[	[	X
bioscience-245	74	37	16	16	NUM
bioscience-245	74	38	]	]	PUNCT
bioscience-245	74	39	.	.	PUNCT
bioscience-245	75	1	statistical	statistical	ADJ
bioscience-245	75	2	analysis	analysis	NOUN
bioscience-245	75	3	the	the	DET
bioscience-245	75	4	obtained	obtain	VERB
bioscience-245	75	5	data	datum	NOUN
bioscience-245	75	6	were	be	AUX
bioscience-245	75	7	statistically	statistically	ADV
bioscience-245	75	8	analyzed	analyze	VERB
bioscience-245	75	9	using	use	VERB
bioscience-245	75	10	the	the	DET
bioscience-245	75	11	spss	spss	PROPN
bioscience-245	75	12	software	software	NOUN
bioscience-245	75	13	(	(	PUNCT
bioscience-245	75	14	version	version	NOUN
bioscience-245	75	15	23	23	NUM
bioscience-245	75	16	;	;	PUNCT
bioscience-245	75	17	spss	spss	PROPN
bioscience-245	75	18	inc	inc	PROPN
bioscience-245	75	19	.	.	PROPN
bioscience-245	75	20	,	,	PUNCT
bioscience-245	75	21	chicago	chicago	PROPN
bioscience-245	75	22	,	,	PUNCT
bioscience-245	75	23	il	il	PROPN
bioscience-245	75	24	,	,	PUNCT
bioscience-245	75	25	usa	usa	PROPN
bioscience-245	75	26	)	)	PUNCT
bioscience-245	75	27	.	.	PUNCT
bioscience-245	76	1	one	one	NUM
bioscience-245	76	2	-	-	PUNCT
bioscience-245	76	3	way	way	NOUN
bioscience-245	76	4	anova	anova	PROPN
bioscience-245	76	5	was	be	AUX
bioscience-245	76	6	employed	employ	VERB
bioscience-245	76	7	in	in	ADP
bioscience-245	76	8	order	order	NOUN
bioscience-245	76	9	to	to	PART
bioscience-245	76	10	evaluate	evaluate	VERB
bioscience-245	76	11	differences	difference	NOUN
bioscience-245	76	12	among	among	ADP
bioscience-245	76	13	the	the	DET
bioscience-245	76	14	groups	group	NOUN
bioscience-245	76	15	in	in	ADP
bioscience-245	76	16	physiological	physiological	ADJ
bioscience-245	76	17	and	and	CCONJ
bioscience-245	76	18	biochemical	biochemical	ADJ
bioscience-245	76	19	parameters	parameter	NOUN
bioscience-245	76	20	.	.	PUNCT
bioscience-245	77	1	when	when	SCONJ
bioscience-245	77	2	appropriate	appropriate	ADJ
bioscience-245	77	3	,	,	PUNCT
bioscience-245	77	4	either	either	CCONJ
bioscience-245	77	5	tukeys	tukey	NOUN
bioscience-245	77	6	hsd	hsd	VERB
bioscience-245	77	7	or	or	CCONJ
bioscience-245	77	8	games	games	PROPN
bioscience-245	77	9	-	-	PUNCT
bioscience-245	77	10	howell	howell	PROPN
bioscience-245	77	11	post	post	X
bioscience-245	77	12	hoc	hoc	X
bioscience-245	77	13	tests	test	NOUN
bioscience-245	77	14	were	be	AUX
bioscience-245	77	15	used	use	VERB
bioscience-245	77	16	to	to	PART
bioscience-245	77	17	determine	determine	VERB
bioscience-245	77	18	specific	specific	ADJ
bioscience-245	77	19	group	group	NOUN
bioscience-245	77	20	differences	difference	NOUN
bioscience-245	77	21	.	.	PUNCT
bioscience-245	78	1	the	the	DET
bioscience-245	78	2	results	result	NOUN
bioscience-245	78	3	are	be	AUX
bioscience-245	78	4	presented	present	VERB
bioscience-245	78	5	as	as	ADP
bioscience-245	78	6	mean	mean	NOUN
bioscience-245	78	7	±	±	NUM
bioscience-245	78	8	standard	standard	ADJ
bioscience-245	78	9	deviation	deviation	NOUN
bioscience-245	78	10	(	(	PUNCT
bioscience-245	78	11	sd	sd	NOUN
bioscience-245	78	12	)	)	PUNCT
bioscience-245	78	13	,	,	PUNCT
bioscience-245	78	14	and	and	CCONJ
bioscience-245	78	15	p	p	X
bioscience-245	78	16	-	-	PUNCT
bioscience-245	78	17	values	value	NOUN
bioscience-245	78	18	less	less	ADJ
bioscience-245	78	19	than	than	ADP
bioscience-245	78	20	0.05	0.05	NUM
bioscience-245	78	21	were	be	AUX
bioscience-245	78	22	considered	consider	VERB
bioscience-245	78	23	statistically	statistically	ADV
bioscience-245	78	24	significant	significant	ADJ
bioscience-245	78	25	.	.	PUNCT
bioscience-245	79	1	results	result	VERB
bioscience-245	79	2	behavioral	behavioral	ADJ
bioscience-245	79	3	effects	effect	NOUN
bioscience-245	79	4	of	of	ADP
bioscience-245	79	5	l	l	NOUN
bioscience-245	79	6	-	-	NOUN
bioscience-245	79	7	arginine	arginine	NOUN
bioscience-245	79	8	in	in	ADP
bioscience-245	79	9	a	a	DET
bioscience-245	79	10	corticosterone	corticosterone	NOUN
bioscience-245	79	11	-	-	PUNCT
bioscience-245	79	12	induced	induce	VERB
bioscience-245	79	13	depression	depression	NOUN
bioscience-245	79	14	model	model	NOUN
bioscience-245	79	15	corticosterone	corticosterone	NOUN
bioscience-245	79	16	-	-	PUNCT
bioscience-245	79	17	induced	induce	VERB
bioscience-245	79	18	depression	depression	NOUN
bioscience-245	79	19	significantly	significantly	ADV
bioscience-245	79	20	altered	alter	VERB
bioscience-245	79	21	several	several	ADJ
bioscience-245	79	22	important	important	ADJ
bioscience-245	79	23	behavioral	behavioral	ADJ
bioscience-245	79	24	parameters	parameter	NOUN
bioscience-245	79	25	in	in	ADP
bioscience-245	79	26	rats	rat	NOUN
bioscience-245	79	27	.	.	PUNCT
bioscience-245	80	1	compared	compare	VERB
bioscience-245	80	2	to	to	ADP
bioscience-245	80	3	the	the	DET
bioscience-245	80	4	control	control	NOUN
bioscience-245	80	5	group	group	NOUN
bioscience-245	80	6	,	,	PUNCT
bioscience-245	80	7	the	the	DET
bioscience-245	80	8	animals	animal	NOUN
bioscience-245	80	9	exposed	expose	VERB
bioscience-245	80	10	to	to	ADP
bioscience-245	80	11	corticosterone	corticosterone	NOUN
bioscience-245	80	12	exhibited	exhibit	VERB
bioscience-245	80	13	clearly	clearly	ADV
bioscience-245	80	14	reduced	reduce	VERB
bioscience-245	80	15	exploratory	exploratory	ADJ
bioscience-245	80	16	activity	activity	NOUN
bioscience-245	80	17	,	,	PUNCT
bioscience-245	80	18	diminished	diminish	VERB
bioscience-245	80	19	cognitive	cognitive	ADJ
bioscience-245	80	20	function	function	NOUN
bioscience-245	80	21	,	,	PUNCT
bioscience-245	80	22	and	and	CCONJ
bioscience-245	80	23	heightened	heighten	VERB
bioscience-245	80	24	anxiety	anxiety	NOUN
bioscience-245	80	25	-	-	PUNCT
bioscience-245	80	26	like	like	ADJ
bioscience-245	80	27	behavior	behavior	NOUN
bioscience-245	80	28	.	.	PUNCT
bioscience-245	81	1	specifically	specifically	ADV
bioscience-245	81	2	,	,	PUNCT
bioscience-245	81	3	these	these	DET
bioscience-245	81	4	animals	animal	NOUN
bioscience-245	81	5	demonstrated	demonstrate	VERB
bioscience-245	81	6	a	a	DET
bioscience-245	81	7	marked	marked	ADJ
bioscience-245	81	8	and	and	CCONJ
bioscience-245	81	9	consistent	consistent	ADJ
bioscience-245	81	10	decrease	decrease	NOUN
bioscience-245	81	11	in	in	ADP
bioscience-245	81	12	the	the	DET
bioscience-245	81	13	number	number	NOUN
bioscience-245	81	14	of	of	ADP
bioscience-245	81	15	box	box	NOUN
bioscience-245	81	16	crossings	crossing	NOUN
bioscience-245	81	17	(	(	PUNCT
bioscience-245	81	18	by	by	ADP
bioscience-245	81	19	approximately	approximately	ADV
bioscience-245	81	20	70	70	NUM
bioscience-245	81	21	%	%	NOUN
bioscience-245	81	22	)	)	PUNCT
bioscience-245	81	23	and	and	CCONJ
bioscience-245	81	24	center	center	ADJ
bioscience-245	81	25	entries	entry	NOUN
bioscience-245	81	26	(	(	PUNCT
bioscience-245	81	27	by	by	ADP
bioscience-245	81	28	about	about	ADV
bioscience-245	81	29	80	80	NUM
bioscience-245	81	30	%	%	NOUN
bioscience-245	81	31	)	)	PUNCT
bioscience-245	81	32	.	.	PUNCT
bioscience-245	82	1	conversely	conversely	ADV
bioscience-245	82	2	,	,	PUNCT
bioscience-245	82	3	the	the	DET
bioscience-245	82	4	duration	duration	NOUN
bioscience-245	82	5	of	of	ADP
bioscience-245	82	6	freezing	freezing	ADJ
bioscience-245	82	7	behaviora	behaviora	NOUN
bioscience-245	82	8	commonly	commonly	ADV
bioscience-245	82	9	used	use	VERB
bioscience-245	82	10	and	and	CCONJ
bioscience-245	82	11	widely	widely	ADV
bioscience-245	82	12	accepted	accept	VERB
bioscience-245	82	13	indicator	indicator	NOUN
bioscience-245	82	14	of	of	ADP
bioscience-245	82	15	fearincreased	fearincrease	VERB
bioscience-245	82	16	by	by	ADP
bioscience-245	82	17	nearly	nearly	ADV
bioscience-245	82	18	280	280	NUM
bioscience-245	82	19	%	%	NOUN
bioscience-245	82	20	,	,	PUNCT
bioscience-245	82	21	thereby	thereby	ADV
bioscience-245	82	22	highlighting	highlight	VERB
bioscience-245	82	23	a	a	DET
bioscience-245	82	24	substantial	substantial	ADJ
bioscience-245	82	25	rise	rise	NOUN
bioscience-245	82	26	in	in	ADP
bioscience-245	82	27	anxiety	anxiety	NOUN
bioscience-245	82	28	levels	level	NOUN
bioscience-245	82	29	table	table	VERB
bioscience-245	82	30	1	1	NUM
bioscience-245	82	31	.	.	PUNCT
bioscience-245	83	1	furthermore	furthermore	ADV
bioscience-245	83	2	,	,	PUNCT
bioscience-245	83	3	the	the	DET
bioscience-245	83	4	forced	force	VERB
bioscience-245	83	5	swim	swim	NOUN
bioscience-245	83	6	test	test	NOUN
bioscience-245	83	7	(	(	PUNCT
bioscience-245	83	8	fst	fst	NOUN
bioscience-245	83	9	)	)	PUNCT
bioscience-245	83	10	further	far	ADV
bioscience-245	83	11	supported	support	VERB
bioscience-245	83	12	the	the	DET
bioscience-245	83	13	observed	observed	ADJ
bioscience-245	83	14	behavioral	behavioral	ADJ
bioscience-245	83	15	benefits	benefit	NOUN
bioscience-245	83	16	of	of	ADP
bioscience-245	83	17	l	l	NOUN
bioscience-245	83	18	-	-	NOUN
bioscience-245	83	19	arginine	arginine	NOUN
bioscience-245	83	20	,	,	PUNCT
bioscience-245	83	21	clearly	clearly	ADV
bioscience-245	83	22	showing	show	VERB
bioscience-245	83	23	a	a	DET
bioscience-245	83	24	significant	significant	ADJ
bioscience-245	83	25	reduction	reduction	NOUN
bioscience-245	83	26	in	in	ADP
bioscience-245	83	27	immobility	immobility	NOUN
bioscience-245	83	28	time	time	NOUN
bioscience-245	83	29	after	after	ADP
bioscience-245	83	30	treatment	treatment	NOUN
bioscience-245	83	31	figure	figure	NOUN
bioscience-245	83	32	1	1	NUM
bioscience-245	83	33	.	.	PUNCT
bioscience-245	84	1	this	this	DET
bioscience-245	84	2	particular	particular	ADJ
bioscience-245	84	3	outcome	outcome	NOUN
bioscience-245	84	4	is	be	AUX
bioscience-245	84	5	consistent	consistent	ADJ
bioscience-245	84	6	with	with	ADP
bioscience-245	84	7	an	an	DET
bioscience-245	84	8	established	establish	VERB
bioscience-245	84	9	antidepressant	antidepressant	ADJ
bioscience-245	84	10	-	-	PUNCT
bioscience-245	84	11	like	like	ADJ
bioscience-245	84	12	effect	effect	NOUN
bioscience-245	84	13	.	.	PUNCT
bioscience-245	85	1	a	a	DET
bioscience-245	85	2	very	very	ADV
bioscience-245	85	3	similar	similar	ADJ
bioscience-245	85	4	trend	trend	NOUN
bioscience-245	85	5	was	be	AUX
bioscience-245	85	6	also	also	ADV
bioscience-245	85	7	observed	observe	VERB
bioscience-245	85	8	in	in	ADP
bioscience-245	85	9	the	the	DET
bioscience-245	85	10	tail	tail	NOUN
bioscience-245	85	11	suspension	suspension	NOUN
bioscience-245	85	12	test	test	NOUN
bioscience-245	85	13	(	(	PUNCT
bioscience-245	85	14	tst	tst	NOUN
bioscience-245	85	15	)	)	PUNCT
bioscience-245	85	16	,	,	PUNCT
bioscience-245	85	17	where	where	SCONJ
bioscience-245	85	18	l	l	NOUN
bioscience-245	85	19	-	-	PUNCT
bioscience-245	85	20	arginine	arginine	NOUN
bioscience-245	85	21	administration	administration	NOUN
bioscience-245	85	22	significantly	significantly	ADV
bioscience-245	85	23	improved	improve	VERB
bioscience-245	85	24	performance	performance	NOUN
bioscience-245	85	25	metrics	metric	NOUN
bioscience-245	85	26	compared	compare	VERB
bioscience-245	85	27	to	to	ADP
bioscience-245	85	28	the	the	DET
bioscience-245	85	29	untreated	untreated	ADJ
bioscience-245	85	30	depressive	depressive	ADJ
bioscience-245	85	31	group	group	NOUN
bioscience-245	85	32	.	.	PUNCT
bioscience-245	86	1	highlights	highlight	NOUN
bioscience-245	86	2	in	in	ADP
bioscience-245	86	3	bioscience	bioscience	NOUN
bioscience-245	86	4	page	page	NOUN
bioscience-245	86	5	3	3	NUM
bioscience-245	86	6	of	of	ADP
bioscience-245	86	7	7	7	NUM
bioscience-245	86	8	june	june	PROPN
bioscience-245	86	9	2025|volume	2025|volume	NUM
bioscience-245	86	10	8	8	NUM
bioscience-245	86	11	http://bioscience.highlightsin.org/	http://bioscience.highlightsin.org/	NOUN
bioscience-245	86	12	mantashashvili	mantashashvili	NOUN
bioscience-245	87	1	t	t	PROPN
bioscience-245	87	2	et	et	PROPN
bioscience-245	87	3	al	al	PROPN
bioscience-245	87	4	.	.	PROPN
bioscience-245	87	5	,	,	PUNCT
bioscience-245	87	6	2025	2025	NUM
bioscience-245	87	7	l	l	NOUN
bioscience-245	87	8	-	-	NOUN
bioscience-245	87	9	arginine	arginine	NOUN
bioscience-245	87	10	as	as	ADP
bioscience-245	87	11	a	a	DET
bioscience-245	87	12	potential	potential	ADJ
bioscience-245	87	13	antidepressant	antidepressant	NOUN
bioscience-245	87	14	:	:	PUNCT
bioscience-245	87	15	effects	effect	NOUN
bioscience-245	87	16	on	on	ADP
bioscience-245	87	17	cognitive	cognitive	ADJ
bioscience-245	87	18	function	function	NOUN
bioscience-245	87	19	figure	figure	NOUN
bioscience-245	87	20	3	3	NUM
bioscience-245	87	21	.	.	PUNCT
bioscience-245	87	22	effect	effect	NOUN
bioscience-245	87	23	of	of	ADP
bioscience-245	87	24	l	l	NOUN
bioscience-245	87	25	-	-	NOUN
bioscience-245	87	26	arginine	arginine	NOUN
bioscience-245	87	27	on	on	ADP
bioscience-245	87	28	nitric	nitric	ADJ
bioscience-245	87	29	oxide	oxide	NOUN
bioscience-245	87	30	and	and	CCONJ
bioscience-245	87	31	malondialdehyde	malondialdehyde	NOUN
bioscience-245	87	32	content	content	NOUN
bioscience-245	87	33	in	in	ADP
bioscience-245	87	34	prefrontal	prefrontal	ADJ
bioscience-245	87	35	cortex	cortex	NOUN
bioscience-245	87	36	and	and	CCONJ
bioscience-245	87	37	hippocampal	hippocampal	ADJ
bioscience-245	87	38	cells	cell	NOUN
bioscience-245	87	39	of	of	ADP
bioscience-245	87	40	depressed	depressed	ADJ
bioscience-245	87	41	.	.	PUNCT
bioscience-245	88	1	figure	figure	NOUN
bioscience-245	88	2	4	4	NUM
bioscience-245	88	3	.	.	PUNCT
bioscience-245	89	1	effect	effect	NOUN
bioscience-245	89	2	of	of	ADP
bioscience-245	89	3	l	l	NOUN
bioscience-245	89	4	-	-	NOUN
bioscience-245	89	5	arginine	arginine	NOUN
bioscience-245	89	6	on	on	ADP
bioscience-245	89	7	superoxide	superoxide	NOUN
bioscience-245	89	8	dismutase	dismutase	NOUN
bioscience-245	89	9	and	and	CCONJ
bioscience-245	89	10	catalase	catalase	NOUN
bioscience-245	89	11	activity	activity	NOUN
bioscience-245	89	12	in	in	ADP
bioscience-245	89	13	prefrontal	prefrontal	ADJ
bioscience-245	89	14	cortex	cortex	NOUN
bioscience-245	89	15	and	and	CCONJ
bioscience-245	89	16	hippocampal	hippocampal	ADJ
bioscience-245	89	17	cells	cell	NOUN
bioscience-245	89	18	of	of	ADP
bioscience-245	89	19	depressed	depressed	ADJ
bioscience-245	89	20	individuals	individual	NOUN
bioscience-245	89	21	.	.	PUNCT
bioscience-245	90	1	effect	effect	NOUN
bioscience-245	90	2	of	of	ADP
bioscience-245	90	3	l	l	NOUN
bioscience-245	90	4	-	-	NOUN
bioscience-245	90	5	arginine	arginine	NOUN
bioscience-245	90	6	on	on	ADP
bioscience-245	90	7	the	the	DET
bioscience-245	90	8	hormonal	hormonal	ADJ
bioscience-245	90	9	status	status	NOUN
bioscience-245	90	10	of	of	ADP
bioscience-245	90	11	depressed	depressed	ADJ
bioscience-245	90	12	animals	animal	NOUN
bioscience-245	90	13	impact	impact	NOUN
bioscience-245	90	14	on	on	ADP
bioscience-245	90	15	serotonergic	serotonergic	ADJ
bioscience-245	90	16	activity	activity	NOUN
bioscience-245	90	17	quantitative	quantitative	ADJ
bioscience-245	90	18	analysis	analysis	NOUN
bioscience-245	90	19	of	of	ADP
bioscience-245	90	20	serotonin	serotonin	NOUN
bioscience-245	90	21	levels	level	NOUN
bioscience-245	90	22	in	in	ADP
bioscience-245	90	23	the	the	DET
bioscience-245	90	24	prefrontal	prefrontal	ADJ
bioscience-245	90	25	cortex	cortex	NOUN
bioscience-245	90	26	revealed	reveal	VERB
bioscience-245	90	27	a	a	DET
bioscience-245	90	28	marked	mark	VERB
bioscience-245	90	29	decline	decline	NOUN
bioscience-245	90	30	(	(	PUNCT
bioscience-245	90	31	approximately	approximately	ADV
bioscience-245	90	32	28	28	NUM
bioscience-245	90	33	%	%	NOUN
bioscience-245	90	34	)	)	PUNCT
bioscience-245	90	35	in	in	ADP
bioscience-245	90	36	corticosterone	corticosterone	NOUN
bioscience-245	90	37	treated	treat	VERB
bioscience-245	90	38	rats	rat	NOUN
bioscience-245	90	39	relative	relative	ADJ
bioscience-245	90	40	to	to	ADP
bioscience-245	90	41	controls	control	NOUN
bioscience-245	90	42	figure	figure	NOUN
bioscience-245	90	43	2a	2a	NUM
bioscience-245	90	44	.	.	PUNCT
bioscience-245	91	1	however	however	ADV
bioscience-245	91	2	,	,	PUNCT
bioscience-245	91	3	l	l	NOUN
bioscience-245	91	4	-	-	PUNCT
bioscience-245	91	5	arginine	arginine	NOUN
bioscience-245	91	6	supplementation	supplementation	NOUN
bioscience-245	91	7	led	lead	VERB
bioscience-245	91	8	to	to	ADP
bioscience-245	91	9	a	a	DET
bioscience-245	91	10	substantial	substantial	ADJ
bioscience-245	91	11	increase	increase	NOUN
bioscience-245	91	12	(	(	PUNCT
bioscience-245	91	13	approximately	approximately	ADV
bioscience-245	91	14	35	35	NUM
bioscience-245	91	15	%	%	NOUN
bioscience-245	91	16	)	)	PUNCT
bioscience-245	91	17	in	in	ADP
bioscience-245	91	18	serotonin	serotonin	NOUN
bioscience-245	91	19	concentration	concentration	NOUN
bioscience-245	91	20	compared	compare	VERB
bioscience-245	91	21	to	to	ADP
bioscience-245	91	22	the	the	DET
bioscience-245	91	23	untreated	untreated	ADJ
bioscience-245	91	24	depressive	depressive	ADJ
bioscience-245	91	25	group	group	NOUN
bioscience-245	91	26	figure	figure	NOUN
bioscience-245	91	27	3a	3a	NUM
bioscience-245	91	28	.	.	PUNCT
bioscience-245	92	1	similar	similar	ADJ
bioscience-245	92	2	recovery	recovery	NOUN
bioscience-245	92	3	patterns	pattern	NOUN
bioscience-245	92	4	were	be	AUX
bioscience-245	92	5	observed	observe	VERB
bioscience-245	92	6	in	in	ADP
bioscience-245	92	7	the	the	DET
bioscience-245	92	8	hippocampus	hippocampus	NOUN
bioscience-245	92	9	table	table	NOUN
bioscience-245	92	10	2	2	NUM
bioscience-245	92	11	,	,	PUNCT
bioscience-245	92	12	indicating	indicate	VERB
bioscience-245	92	13	that	that	SCONJ
bioscience-245	92	14	larginine	larginine	NOUN
bioscience-245	92	15	may	may	AUX
bioscience-245	92	16	exert	exert	VERB
bioscience-245	92	17	its	its	PRON
bioscience-245	92	18	antidepressant	antidepressant	ADJ
bioscience-245	92	19	effects	effect	NOUN
bioscience-245	92	20	at	at	ADP
bioscience-245	92	21	least	least	ADJ
bioscience-245	92	22	in	in	ADP
bioscience-245	92	23	part	part	NOUN
bioscience-245	92	24	via	via	ADP
bioscience-245	92	25	the	the	DET
bioscience-245	92	26	restoration	restoration	NOUN
bioscience-245	92	27	of	of	ADP
bioscience-245	92	28	monoaminergic	monoaminergic	ADJ
bioscience-245	92	29	neurotransmission	neurotransmission	NOUN
bioscience-245	92	30	.	.	PUNCT
bioscience-245	93	1	the	the	DET
bioscience-245	93	2	results	result	NOUN
bioscience-245	93	3	obtained	obtain	VERB
bioscience-245	93	4	also	also	ADV
bioscience-245	93	5	show	show	VERB
bioscience-245	93	6	that	that	SCONJ
bioscience-245	93	7	administration	administration	NOUN
bioscience-245	93	8	of	of	ADP
bioscience-245	93	9	the	the	DET
bioscience-245	93	10	serotonin	serotonin	VERB
bioscience-245	93	11	reuptake	reuptake	NOUN
bioscience-245	93	12	inhibitor	inhibitor	NOUN
bioscience-245	93	13	fluoxetine	fluoxetine	NOUN
bioscience-245	93	14	produced	produce	VERB
bioscience-245	93	15	similar	similar	ADJ
bioscience-245	93	16	effects	effect	NOUN
bioscience-245	93	17	in	in	ADP
bioscience-245	93	18	the	the	DET
bioscience-245	93	19	depressed	depressed	ADJ
bioscience-245	93	20	group	group	NOUN
bioscience-245	93	21	of	of	ADP
bioscience-245	93	22	animals	animal	NOUN
bioscience-245	93	23	.	.	PUNCT
bioscience-245	94	1	effect	effect	NOUN
bioscience-245	94	2	of	of	ADP
bioscience-245	94	3	l	l	NOUN
bioscience-245	94	4	-	-	NOUN
bioscience-245	94	5	arginine	arginine	NOUN
bioscience-245	94	6	on	on	ADP
bioscience-245	94	7	nitric	nitric	ADJ
bioscience-245	94	8	oxide	oxide	NOUN
bioscience-245	94	9	and	and	CCONJ
bioscience-245	94	10	malondialdehyde	malondialdehyde	NOUN
bioscience-245	94	11	levels	level	NOUN
bioscience-245	94	12	in	in	ADP
bioscience-245	94	13	the	the	DET
bioscience-245	94	14	brain	brain	NOUN
bioscience-245	94	15	cells	cell	NOUN
bioscience-245	94	16	of	of	ADP
bioscience-245	94	17	depressed	depressed	ADJ
bioscience-245	94	18	animals	animal	NOUN
bioscience-245	94	19	studies	study	NOUN
bioscience-245	94	20	have	have	AUX
bioscience-245	94	21	shown	show	VERB
bioscience-245	94	22	a	a	DET
bioscience-245	94	23	significant	significant	ADJ
bioscience-245	94	24	increase	increase	NOUN
bioscience-245	94	25	in	in	ADP
bioscience-245	94	26	nitric	nitric	ADJ
bioscience-245	94	27	oxide	oxide	NOUN
bioscience-245	94	28	levels	level	NOUN
bioscience-245	94	29	in	in	ADP
bioscience-245	94	30	the	the	DET
bioscience-245	94	31	prefrontal	prefrontal	ADJ
bioscience-245	94	32	cortex	cortex	NOUN
bioscience-245	94	33	and	and	CCONJ
bioscience-245	94	34	hippocampus	hippocampus	NOUN
bioscience-245	94	35	of	of	ADP
bioscience-245	94	36	depressed	depressed	ADJ
bioscience-245	94	37	individuals	individual	NOUN
bioscience-245	94	38	.	.	PUNCT
bioscience-245	95	1	however	however	ADV
bioscience-245	95	2	,	,	PUNCT
bioscience-245	95	3	14	14	NUM
bioscience-245	95	4	-	-	PUNCT
bioscience-245	95	5	day	day	NOUN
bioscience-245	95	6	administration	administration	NOUN
bioscience-245	95	7	of	of	ADP
bioscience-245	95	8	l	l	NOUN
bioscience-245	95	9	-	-	NOUN
bioscience-245	95	10	arginine	arginine	NOUN
bioscience-245	95	11	to	to	ADP
bioscience-245	95	12	depressed	depressed	ADJ
bioscience-245	95	13	animals	animal	NOUN
bioscience-245	95	14	significantly	significantly	ADV
bioscience-245	95	15	reduced	reduce	VERB
bioscience-245	95	16	these	these	DET
bioscience-245	95	17	levels	level	NOUN
bioscience-245	95	18	by	by	ADP
bioscience-245	95	19	approximately	approximately	ADV
bioscience-245	95	20	30	30	NUM
bioscience-245	95	21	%	%	NOUN
bioscience-245	95	22	and	and	CCONJ
bioscience-245	95	23	35	35	NUM
bioscience-245	95	24	%	%	NOUN
bioscience-245	95	25	,	,	PUNCT
bioscience-245	95	26	respectively	respectively	ADV
bioscience-245	95	27	figure	figure	VERB
bioscience-245	95	28	3	3	NUM
bioscience-245	95	29	a	a	PRON
bioscience-245	95	30	and	and	CCONJ
bioscience-245	95	31	b.	b.	PROPN
bioscience-245	95	32	similar	similar	ADJ
bioscience-245	95	33	effects	effect	NOUN
bioscience-245	95	34	were	be	AUX
bioscience-245	95	35	observed	observe	VERB
bioscience-245	95	36	with	with	ADP
bioscience-245	95	37	fluoxetine	fluoxetine	NOUN
bioscience-245	95	38	treatment	treatment	NOUN
bioscience-245	95	39	.	.	PUNCT
bioscience-245	96	1	changes	change	NOUN
bioscience-245	96	2	in	in	ADP
bioscience-245	96	3	malondialdehyde	malondialdehyde	PROPN
bioscience-245	96	4	levels	level	NOUN
bioscience-245	96	5	alterations	alteration	NOUN
bioscience-245	96	6	were	be	AUX
bioscience-245	96	7	also	also	ADV
bioscience-245	96	8	observed	observe	VERB
bioscience-245	96	9	in	in	ADP
bioscience-245	96	10	malondialdehyde	malondialdehyde	PROPN
bioscience-245	96	11	(	(	PUNCT
bioscience-245	96	12	mda	mda	PROPN
bioscience-245	96	13	)	)	PUNCT
bioscience-245	96	14	levels	level	NOUN
bioscience-245	96	15	.	.	PUNCT
bioscience-245	97	1	as	as	SCONJ
bioscience-245	97	2	shown	show	VERB
bioscience-245	97	3	in	in	ADP
bioscience-245	97	4	figure	figure	NOUN
bioscience-245	97	5	3	3	NUM
bioscience-245	97	6	c	c	NOUN
bioscience-245	97	7	and	and	CCONJ
bioscience-245	97	8	d	d	NOUN
bioscience-245	97	9	,	,	PUNCT
bioscience-245	97	10	corticosterone	corticosterone	NOUN
bioscience-245	97	11	-	-	PUNCT
bioscience-245	97	12	induced	induce	VERB
bioscience-245	97	13	depression	depression	NOUN
bioscience-245	97	14	is	be	AUX
bioscience-245	97	15	associated	associate	VERB
bioscience-245	97	16	with	with	ADP
bioscience-245	97	17	an	an	DET
bioscience-245	97	18	increased	increase	VERB
bioscience-245	97	19	concentration	concentration	NOUN
bioscience-245	97	20	of	of	ADP
bioscience-245	97	21	malondialdehyde	malondialdehyde	NOUN
bioscience-245	97	22	in	in	ADP
bioscience-245	97	23	both	both	CCONJ
bioscience-245	97	24	the	the	DET
bioscience-245	97	25	prefrontal	prefrontal	ADJ
bioscience-245	97	26	cortex	cortex	NOUN
bioscience-245	97	27	and	and	CCONJ
bioscience-245	97	28	hippocampal	hippocampal	ADJ
bioscience-245	97	29	brain	brain	NOUN
bioscience-245	97	30	cells	cell	NOUN
bioscience-245	97	31	.	.	PUNCT
bioscience-245	98	1	however	however	ADV
bioscience-245	98	2	,	,	PUNCT
bioscience-245	98	3	l	l	NOUN
bioscience-245	98	4	-	-	PUNCT
bioscience-245	98	5	arginine	arginine	NOUN
bioscience-245	98	6	administration	administration	NOUN
bioscience-245	98	7	led	lead	VERB
bioscience-245	98	8	to	to	ADP
bioscience-245	98	9	a	a	DET
bioscience-245	98	10	reduction	reduction	NOUN
bioscience-245	98	11	in	in	ADP
bioscience-245	98	12	its	its	PRON
bioscience-245	98	13	levels	level	NOUN
bioscience-245	98	14	by	by	ADP
bioscience-245	98	15	approximately	approximately	ADV
bioscience-245	98	16	20	20	NUM
bioscience-245	98	17	%	%	NOUN
bioscience-245	98	18	in	in	ADP
bioscience-245	98	19	the	the	DET
bioscience-245	98	20	prefrontal	prefrontal	ADJ
bioscience-245	98	21	cortex	cortex	NOUN
bioscience-245	98	22	and	and	CCONJ
bioscience-245	98	23	about	about	ADV
bioscience-245	98	24	30	30	NUM
bioscience-245	98	25	%	%	NOUN
bioscience-245	98	26	in	in	ADP
bioscience-245	98	27	the	the	DET
bioscience-245	98	28	hippocampus	hippocampus	NOUN
bioscience-245	98	29	.	.	PUNCT
bioscience-245	99	1	these	these	DET
bioscience-245	99	2	findings	finding	NOUN
bioscience-245	99	3	suggest	suggest	VERB
bioscience-245	99	4	that	that	SCONJ
bioscience-245	99	5	corticosterone	corticosterone	NOUN
bioscience-245	99	6	-	-	PUNCT
bioscience-245	99	7	induced	induce	VERB
bioscience-245	99	8	depression	depression	NOUN
bioscience-245	99	9	is	be	AUX
bioscience-245	99	10	accompanied	accompany	VERB
bioscience-245	99	11	by	by	ADP
bioscience-245	99	12	increased	increase	VERB
bioscience-245	99	13	lipid	lipid	NOUN
bioscience-245	99	14	peroxidation	peroxidation	NOUN
bioscience-245	99	15	,	,	PUNCT
bioscience-245	99	16	which	which	PRON
bioscience-245	99	17	decreases	decrease	VERB
bioscience-245	99	18	and	and	CCONJ
bioscience-245	99	19	approaches	approach	VERB
bioscience-245	99	20	control	control	NOUN
bioscience-245	99	21	levels	level	NOUN
bioscience-245	99	22	following	follow	VERB
bioscience-245	99	23	l	l	ADJ
bioscience-245	99	24	-	-	PUNCT
bioscience-245	99	25	arginine	arginine	NOUN
bioscience-245	99	26	treatment	treatment	NOUN
bioscience-245	99	27	.	.	PUNCT
bioscience-245	100	1	as	as	ADP
bioscience-245	100	2	with	with	ADP
bioscience-245	100	3	previous	previous	ADJ
bioscience-245	100	4	parameters	parameter	NOUN
bioscience-245	100	5	,	,	PUNCT
bioscience-245	100	6	fluoxetine	fluoxetine	NOUN
bioscience-245	100	7	administration	administration	NOUN
bioscience-245	100	8	similarly	similarly	ADV
bioscience-245	100	9	reduced	reduce	VERB
bioscience-245	100	10	malondialdehyde	malondialdehyde	PROPN
bioscience-245	100	11	content	content	NOUN
bioscience-245	100	12	.	.	PUNCT
bioscience-245	101	1	effect	effect	NOUN
bioscience-245	101	2	of	of	ADP
bioscience-245	101	3	l	l	NOUN
bioscience-245	101	4	-	-	NOUN
bioscience-245	101	5	arginine	arginine	NOUN
bioscience-245	101	6	on	on	ADP
bioscience-245	101	7	the	the	DET
bioscience-245	101	8	activity	activity	NOUN
bioscience-245	101	9	of	of	ADP
bioscience-245	101	10	antioxidant	antioxidant	ADJ
bioscience-245	101	11	enzymes	enzyme	NOUN
bioscience-245	101	12	in	in	ADP
bioscience-245	101	13	depressed	depressed	ADJ
bioscience-245	101	14	animals	animal	NOUN
bioscience-245	101	15	the	the	DET
bioscience-245	101	16	activities	activity	NOUN
bioscience-245	101	17	of	of	ADP
bioscience-245	101	18	key	key	ADJ
bioscience-245	101	19	antioxidant	antioxidant	ADJ
bioscience-245	101	20	enzymes	enzyme	NOUN
bioscience-245	101	21	superoxide	superoxide	NOUN
bioscience-245	101	22	dismutase	dismutase	NOUN
bioscience-245	101	23	(	(	PUNCT
bioscience-245	101	24	sod	sod	NOUN
bioscience-245	101	25	)	)	PUNCT
bioscience-245	101	26	and	and	CCONJ
bioscience-245	101	27	catalasewere	catalasewere	NOUN
bioscience-245	101	28	evaluated	evaluate	VERB
bioscience-245	101	29	across	across	ADP
bioscience-245	101	30	the	the	DET
bioscience-245	101	31	experimental	experimental	ADJ
bioscience-245	101	32	groups	group	NOUN
bioscience-245	101	33	,	,	PUNCT
bioscience-245	101	34	as	as	SCONJ
bioscience-245	101	35	presented	present	VERB
bioscience-245	101	36	in	in	ADP
bioscience-245	101	37	figure	figure	NOUN
bioscience-245	101	38	4	4	NUM
bioscience-245	101	39	.	.	PUNCT
bioscience-245	101	40	as	as	SCONJ
bioscience-245	101	41	shown	show	VERB
bioscience-245	101	42	in	in	ADP
bioscience-245	101	43	figure	figure	NOUN
bioscience-245	101	44	4a	4a	NOUN
bioscience-245	101	45	,	,	PUNCT
bioscience-245	101	46	sod	sod	NOUN
bioscience-245	101	47	activity	activity	NOUN
bioscience-245	101	48	in	in	ADP
bioscience-245	101	49	the	the	DET
bioscience-245	101	50	prefrontal	prefrontal	ADJ
bioscience-245	101	51	cortex	cortex	NOUN
bioscience-245	101	52	of	of	ADP
bioscience-245	101	53	depressed	depressed	ADJ
bioscience-245	101	54	animals	animal	NOUN
bioscience-245	101	55	was	be	AUX
bioscience-245	101	56	significantly	significantly	ADV
bioscience-245	101	57	decreased	decrease	VERB
bioscience-245	101	58	(	(	PUNCT
bioscience-245	101	59	approximately	approximately	ADV
bioscience-245	101	60	51	51	NUM
bioscience-245	101	61	%	%	NOUN
bioscience-245	101	62	)	)	PUNCT
bioscience-245	101	63	compared	compare	VERB
bioscience-245	101	64	to	to	ADP
bioscience-245	101	65	the	the	DET
bioscience-245	101	66	control	control	NOUN
bioscience-245	101	67	group	group	NOUN
bioscience-245	101	68	.	.	PUNCT
bioscience-245	102	1	however	however	ADV
bioscience-245	102	2	,	,	PUNCT
bioscience-245	102	3	after	after	ADP
bioscience-245	102	4	14	14	NUM
bioscience-245	102	5	days	day	NOUN
bioscience-245	102	6	of	of	ADP
bioscience-245	102	7	l	l	NOUN
bioscience-245	102	8	-	-	PUNCT
bioscience-245	102	9	arginine	arginine	NOUN
bioscience-245	102	10	administration	administration	NOUN
bioscience-245	102	11	,	,	PUNCT
bioscience-245	102	12	enzyme	enzyme	NOUN
bioscience-245	102	13	activity	activity	NOUN
bioscience-245	102	14	significantly	significantly	ADV
bioscience-245	102	15	increased	increase	VERB
bioscience-245	102	16	and	and	CCONJ
bioscience-245	102	17	approached	approach	VERB
bioscience-245	102	18	the	the	DET
bioscience-245	102	19	control	control	NOUN
bioscience-245	102	20	values	value	NOUN
bioscience-245	102	21	.	.	PUNCT
bioscience-245	103	1	similar	similar	ADJ
bioscience-245	103	2	trends	trend	NOUN
bioscience-245	103	3	were	be	AUX
bioscience-245	103	4	observed	observe	VERB
bioscience-245	103	5	in	in	ADP
bioscience-245	103	6	the	the	DET
bioscience-245	103	7	hippocampus	hippocampus	NOUN
bioscience-245	103	8	figure	figure	NOUN
bioscience-245	103	9	4	4	NUM
bioscience-245	103	10	b	b	NOUN
bioscience-245	103	11	,	,	PUNCT
bioscience-245	103	12	although	although	SCONJ
bioscience-245	103	13	overall	overall	ADJ
bioscience-245	103	14	sod	sod	NOUN
bioscience-245	103	15	activity	activity	NOUN
bioscience-245	103	16	in	in	ADP
bioscience-245	103	17	this	this	DET
bioscience-245	103	18	region	region	NOUN
bioscience-245	103	19	was	be	AUX
bioscience-245	103	20	lower	low	ADJ
bioscience-245	103	21	than	than	ADP
bioscience-245	103	22	in	in	ADP
bioscience-245	103	23	the	the	DET
bioscience-245	103	24	cortex	cortex	NOUN
bioscience-245	103	25	across	across	ADP
bioscience-245	103	26	all	all	DET
bioscience-245	103	27	groups	group	NOUN
bioscience-245	103	28	.	.	PUNCT
bioscience-245	104	1	comparable	comparable	ADJ
bioscience-245	104	2	patterns	pattern	NOUN
bioscience-245	104	3	were	be	AUX
bioscience-245	104	4	noted	note	VERB
bioscience-245	104	5	for	for	ADP
bioscience-245	104	6	catalase	catalase	NOUN
bioscience-245	104	7	activity	activity	NOUN
bioscience-245	104	8	.	.	PUNCT
bioscience-245	105	1	in	in	ADP
bioscience-245	105	2	the	the	DET
bioscience-245	105	3	prefrontal	prefrontal	ADJ
bioscience-245	105	4	cortex	cortex	NOUN
bioscience-245	105	5	figure	figure	NOUN
bioscience-245	105	6	4c	4c	NOUN
bioscience-245	105	7	,	,	PUNCT
bioscience-245	105	8	catalase	catalase	NOUN
bioscience-245	105	9	activity	activity	NOUN
bioscience-245	105	10	was	be	AUX
bioscience-245	105	11	reduced	reduce	VERB
bioscience-245	105	12	by	by	ADP
bioscience-245	105	13	approximately	approximately	ADV
bioscience-245	105	14	47	47	NUM
bioscience-245	105	15	%	%	NOUN
bioscience-245	105	16	in	in	ADP
bioscience-245	105	17	the	the	DET
bioscience-245	105	18	depressed	depressed	ADJ
bioscience-245	105	19	group	group	NOUN
bioscience-245	105	20	,	,	PUNCT
bioscience-245	105	21	while	while	SCONJ
bioscience-245	105	22	l	l	NOUN
bioscience-245	105	23	-	-	PUNCT
bioscience-245	105	24	arginine	arginine	NOUN
bioscience-245	105	25	administration	administration	NOUN
bioscience-245	105	26	resulted	result	VERB
bioscience-245	105	27	in	in	ADP
bioscience-245	105	28	a	a	DET
bioscience-245	105	29	60	60	NUM
bioscience-245	105	30	%	%	NOUN
bioscience-245	105	31	increase	increase	NOUN
bioscience-245	105	32	.	.	PUNCT
bioscience-245	106	1	similar	similar	ADJ
bioscience-245	106	2	effects	effect	NOUN
bioscience-245	106	3	were	be	AUX
bioscience-245	106	4	also	also	ADV
bioscience-245	106	5	observed	observe	VERB
bioscience-245	106	6	in	in	ADP
bioscience-245	106	7	the	the	DET
bioscience-245	106	8	hippocampal	hippocampal	ADJ
bioscience-245	106	9	cells	cell	NOUN
bioscience-245	106	10	figure	figure	VERB
bioscience-245	106	11	4d	4d	NUM
bioscience-245	106	12	.	.	PUNCT
bioscience-245	107	1	importantly	importantly	ADV
bioscience-245	107	2	,	,	PUNCT
bioscience-245	107	3	fluoxetine	fluoxetine	NOUN
bioscience-245	107	4	treatment	treatment	NOUN
bioscience-245	107	5	led	lead	VERB
bioscience-245	107	6	to	to	ADP
bioscience-245	107	7	changes	change	NOUN
bioscience-245	107	8	comparable	comparable	ADJ
bioscience-245	107	9	to	to	ADP
bioscience-245	107	10	those	those	PRON
bioscience-245	107	11	observed	observe	VERB
bioscience-245	107	12	with	with	ADP
bioscience-245	107	13	l	l	NOUN
bioscience-245	107	14	-	-	NOUN
bioscience-245	107	15	arginine	arginine	NOUN
bioscience-245	107	16	.	.	PUNCT
bioscience-245	108	1	these	these	DET
bioscience-245	108	2	results	result	NOUN
bioscience-245	108	3	indicate	indicate	VERB
bioscience-245	108	4	that	that	SCONJ
bioscience-245	108	5	corticosterone	corticosterone	NOUN
bioscience-245	108	6	-	-	PUNCT
bioscience-245	108	7	induced	induce	VERB
bioscience-245	108	8	depression	depression	NOUN
bioscience-245	108	9	leads	lead	VERB
bioscience-245	108	10	to	to	ADP
bioscience-245	108	11	decreased	decrease	VERB
bioscience-245	108	12	activity	activity	NOUN
bioscience-245	108	13	of	of	ADP
bioscience-245	108	14	antioxidant	antioxidant	ADJ
bioscience-245	108	15	enzymes	enzyme	NOUN
bioscience-245	108	16	(	(	PUNCT
bioscience-245	108	17	sod	sod	NOUN
bioscience-245	108	18	and	and	CCONJ
bioscience-245	108	19	catalase	catalase	NOUN
bioscience-245	108	20	)	)	PUNCT
bioscience-245	108	21	,	,	PUNCT
bioscience-245	108	22	while	while	SCONJ
bioscience-245	108	23	dietary	dietary	ADJ
bioscience-245	108	24	l	l	NOUN
bioscience-245	108	25	-	-	PUNCT
bioscience-245	108	26	arginine	arginine	NOUN
bioscience-245	108	27	supplementation	supplementation	NOUN
bioscience-245	108	28	restores	restore	VERB
bioscience-245	108	29	their	their	PRON
bioscience-245	108	30	activity	activity	NOUN
bioscience-245	108	31	.	.	PUNCT
bioscience-245	109	1	table	table	NOUN
bioscience-245	109	2	2	2	NUM
bioscience-245	109	3	.	.	PUNCT
bioscience-245	109	4	quantitative	quantitative	ADJ
bioscience-245	109	5	changes	change	NOUN
bioscience-245	109	6	in	in	ADP
bioscience-245	109	7	serotonin	serotonin	NOUN
bioscience-245	109	8	levels	level	NOUN
bioscience-245	109	9	in	in	ADP
bioscience-245	109	10	the	the	DET
bioscience-245	109	11	prefrontal	prefrontal	ADJ
bioscience-245	109	12	cortex	cortex	NOUN
bioscience-245	109	13	and	and	CCONJ
bioscience-245	109	14	hippocampus	hippocampus	NOUN
bioscience-245	109	15	cells	cell	NOUN
bioscience-245	109	16	of	of	ADP
bioscience-245	109	17	depressed	depressed	ADJ
bioscience-245	109	18	rats	rat	NOUN
bioscience-245	109	19	after	after	ADP
bioscience-245	109	20	receiving	receive	VERB
bioscience-245	109	21	l	l	NOUN
bioscience-245	109	22	-	-	NOUN
bioscience-245	109	23	arginine	arginine	NOUN
bioscience-245	109	24	.	.	PUNCT
bioscience-245	110	1	group	group	NOUN
bioscience-245	110	2	prefrontal	prefrontal	ADJ
bioscience-245	110	3	cortex	cortex	NOUN
bioscience-245	110	4	hippocampus	hippocampus	NOUN
bioscience-245	110	5	i	i	PRON
bioscience-245	110	6	group	group	NOUN
bioscience-245	110	7	55.7	55.7	NUM
bioscience-245	110	8	±	±	NUM
bioscience-245	110	9	9.8	9.8	NUM
bioscience-245	110	10	58.9	58.9	NUM
bioscience-245	110	11	±	±	NUM
bioscience-245	110	12	8.6	8.6	NUM
bioscience-245	110	13	ii	ii	PROPN
bioscience-245	110	14	group	group	NOUN
bioscience-245	110	15	38.3	38.3	NUM
bioscience-245	110	16	±6.3∗∗∗	±6.3∗∗∗	NOUN
bioscience-245	110	17	40.2	40.2	NUM
bioscience-245	110	18	±5.7∗∗	±5.7∗∗	PROPN
bioscience-245	110	19	iii	iii	NUM
bioscience-245	110	20	group	group	NOUN
bioscience-245	110	21	60.8	60.8	NUM
bioscience-245	110	22	±12.5	±12.5	ADV
bioscience-245	110	23	#	#	SYM
bioscience-245	110	24	#	#	NOUN
bioscience-245	110	25	50.0	50.0	NUM
bioscience-245	110	26	±5.5	±5.5	NOUN
bioscience-245	110	27	#	#	NOUN
bioscience-245	110	28	iv	iv	NUM
bioscience-245	110	29	group	group	NOUN
bioscience-245	110	30	68.5	68.5	NUM
bioscience-245	110	31	±12.8	±12.8	ADP
bioscience-245	110	32	#	#	SYM
bioscience-245	110	33	#	#	SYM
bioscience-245	110	34	#	#	NOUN
bioscience-245	110	35	52.7	52.7	NUM
bioscience-245	110	36	±7.4	±7.4	PROPN
bioscience-245	110	37	#	#	SYM
bioscience-245	110	38	#	#	NOUN
bioscience-245	110	39	data	datum	NOUN
bioscience-245	110	40	are	be	AUX
bioscience-245	110	41	shown	show	VERB
bioscience-245	110	42	as	as	ADP
bioscience-245	110	43	mean	mean	PROPN
bioscience-245	110	44	±	±	NUM
bioscience-245	110	45	sd	sd	NOUN
bioscience-245	110	46	;	;	PUNCT
bioscience-245	110	47	∗	∗	NOUN
bioscience-245	110	48	,	,	PUNCT
bioscience-245	110	49	the	the	DET
bioscience-245	110	50	difference	difference	NOUN
bioscience-245	110	51	compared	compare	VERB
bioscience-245	110	52	to	to	ADP
bioscience-245	110	53	control	control	NOUN
bioscience-245	110	54	;	;	PUNCT
bioscience-245	110	55	#	#	X
bioscience-245	110	56	,	,	PUNCT
bioscience-245	110	57	the	the	DET
bioscience-245	110	58	difference	difference	NOUN
bioscience-245	110	59	compared	compare	VERB
bioscience-245	110	60	to	to	ADP
bioscience-245	110	61	cortinduced	cortinduce	VERB
bioscience-245	110	62	depression	depression	NOUN
bioscience-245	110	63	;	;	PUNCT
bioscience-245	110	64	∗	∗	NOUN
bioscience-245	110	65	,	,	PUNCT
bioscience-245	110	66	#	#	NOUN
bioscience-245	110	67	,	,	PUNCT
bioscience-245	110	68	p	p	X
bioscience-245	110	69	<	<	X
bioscience-245	110	70	0.05	0.05	NUM
bioscience-245	110	71	;	;	PUNCT
bioscience-245	110	72	∗∗	∗∗	NOUN
bioscience-245	110	73	,	,	PUNCT
bioscience-245	110	74	#	#	SYM
bioscience-245	110	75	#	#	NOUN
bioscience-245	110	76	,	,	PUNCT
bioscience-245	110	77	p	p	X
bioscience-245	110	78	<	<	X
bioscience-245	110	79	0.01	0.01	NUM
bioscience-245	110	80	;	;	PUNCT
bioscience-245	110	81	∗∗∗	∗∗∗	NUM
bioscience-245	110	82	,	,	PUNCT
bioscience-245	110	83	#	#	SYM
bioscience-245	110	84	#	#	SYM
bioscience-245	110	85	#	#	NOUN
bioscience-245	110	86	,	,	PUNCT
bioscience-245	110	87	p	p	X
bioscience-245	110	88	<	<	X
bioscience-245	110	89	0.001	0.001	NUM
bioscience-245	110	90	.	.	PUNCT
bioscience-245	111	1	highlights	highlight	NOUN
bioscience-245	111	2	in	in	ADP
bioscience-245	111	3	bioscience	bioscience	NOUN
bioscience-245	111	4	page	page	NOUN
bioscience-245	111	5	4	4	NUM
bioscience-245	111	6	of	of	ADP
bioscience-245	111	7	7	7	NUM
bioscience-245	111	8	june	june	PROPN
bioscience-245	111	9	2025|volume	2025|volume	NUM
bioscience-245	111	10	8	8	NUM
bioscience-245	111	11	http://bioscience.highlightsin.org/	http://bioscience.highlightsin.org/	NOUN
bioscience-245	111	12	mantashashvili	mantashashvili	NOUN
bioscience-245	111	13	t	t	PROPN
bioscience-245	111	14	et	et	PROPN
bioscience-245	111	15	al	al	PROPN
bioscience-245	111	16	.	.	PROPN
bioscience-245	111	17	,	,	PUNCT
bioscience-245	111	18	2025	2025	NUM
bioscience-245	111	19	l	l	NOUN
bioscience-245	111	20	-	-	NOUN
bioscience-245	111	21	arginine	arginine	NOUN
bioscience-245	111	22	as	as	ADP
bioscience-245	111	23	a	a	DET
bioscience-245	111	24	potential	potential	ADJ
bioscience-245	111	25	antidepressant	antidepressant	NOUN
bioscience-245	111	26	:	:	PUNCT
bioscience-245	111	27	effects	effect	NOUN
bioscience-245	111	28	on	on	ADP
bioscience-245	111	29	cognitive	cognitive	ADJ
bioscience-245	111	30	function	function	NOUN
bioscience-245	111	31	figure	figure	NOUN
bioscience-245	111	32	5	5	NUM
bioscience-245	111	33	.	.	PUNCT
bioscience-245	111	34	effect	effect	NOUN
bioscience-245	111	35	of	of	ADP
bioscience-245	111	36	exogenous	exogenous	ADJ
bioscience-245	111	37	l	l	NOUN
bioscience-245	111	38	-	-	NOUN
bioscience-245	111	39	arginine	arginine	NOUN
bioscience-245	111	40	on	on	ADP
bioscience-245	111	41	superoxide	superoxide	NOUN
bioscience-245	111	42	dismutase	dismutase	NOUN
bioscience-245	111	43	vmax	vmax	NOUN
bioscience-245	111	44	and	and	CCONJ
bioscience-245	111	45	km	km	NOUN
bioscience-245	111	46	in	in	ADP
bioscience-245	111	47	depressed	depressed	ADJ
bioscience-245	111	48	rats	rat	NOUN
bioscience-245	111	49	.	.	PUNCT
bioscience-245	112	1	figure	figure	VERB
bioscience-245	112	2	6	6	NUM
bioscience-245	112	3	.	.	PUNCT
bioscience-245	113	1	effect	effect	NOUN
bioscience-245	113	2	of	of	ADP
bioscience-245	113	3	exogenous	exogenous	ADJ
bioscience-245	113	4	l	l	NOUN
bioscience-245	113	5	-	-	NOUN
bioscience-245	113	6	arginine	arginine	NOUN
bioscience-245	113	7	on	on	ADP
bioscience-245	113	8	catalase	catalase	NOUN
bioscience-245	113	9	vmax	vmax	PROPN
bioscience-245	113	10	and	and	CCONJ
bioscience-245	113	11	km	km	NOUN
bioscience-245	113	12	in	in	ADP
bioscience-245	113	13	depressed	depressed	ADJ
bioscience-245	113	14	rats	rat	NOUN
bioscience-245	113	15	.	.	PUNCT
bioscience-245	114	1	notes	note	NOUN
bioscience-245	114	2	:	:	PUNCT
bioscience-245	114	3	on	on	SCONJ
bioscience-245	114	4	the	the	DET
bioscience-245	114	5	ordinate	ordinate	NOUN
bioscience-245	114	6	axis	axis	NOUN
bioscience-245	114	7	1	1	NUM
bioscience-245	114	8	/	/	SYM
bioscience-245	114	9	v	v	NOUN
bioscience-245	114	10	;	;	PUNCT
bioscience-245	114	11	on	on	ADP
bioscience-245	114	12	the	the	DET
bioscience-245	114	13	abscissa	abscissa	ADJ
bioscience-245	114	14	axis	axis	NOUN
bioscience-245	114	15	substrate	substrate	NOUN
bioscience-245	114	16	concentration	concentration	NOUN
bioscience-245	114	17	(	(	PUNCT
bioscience-245	114	18	mm	mm	NOUN
bioscience-245	114	19	)	)	PUNCT
bioscience-245	114	20	.	.	PUNCT
bioscience-245	115	1	kinetics	kinetic	NOUN
bioscience-245	115	2	of	of	ADP
bioscience-245	115	3	sod	sod	NOUN
bioscience-245	115	4	and	and	CCONJ
bioscience-245	115	5	catalase	catalase	NOUN
bioscience-245	115	6	and	and	CCONJ
bioscience-245	115	7	the	the	DET
bioscience-245	115	8	effect	effect	NOUN
bioscience-245	115	9	of	of	ADP
bioscience-245	115	10	l	l	NOUN
bioscience-245	115	11	-	-	NOUN
bioscience-245	115	12	arginine	arginine	NOUN
bioscience-245	115	13	to	to	PART
bioscience-245	115	14	investigate	investigate	VERB
bioscience-245	115	15	the	the	DET
bioscience-245	115	16	mechanisms	mechanism	NOUN
bioscience-245	115	17	underlying	underlie	VERB
bioscience-245	115	18	enzyme	enzyme	NOUN
bioscience-245	115	19	activity	activity	NOUN
bioscience-245	115	20	changes	change	NOUN
bioscience-245	115	21	,	,	PUNCT
bioscience-245	115	22	kinetic	kinetic	ADJ
bioscience-245	115	23	parameters	parameter	NOUN
bioscience-245	115	24	were	be	AUX
bioscience-245	115	25	assessed	assess	VERB
bioscience-245	115	26	.	.	PUNCT
bioscience-245	116	1	as	as	SCONJ
bioscience-245	116	2	shown	show	VERB
bioscience-245	116	3	in	in	ADP
bioscience-245	116	4	figure	figure	NOUN
bioscience-245	116	5	5	5	NUM
bioscience-245	116	6	a	a	PRON
bioscience-245	116	7	,	,	PUNCT
bioscience-245	116	8	the	the	DET
bioscience-245	116	9	maximum	maximum	ADJ
bioscience-245	116	10	velocity	velocity	NOUN
bioscience-245	116	11	(	(	PUNCT
bioscience-245	116	12	vmax	vmax	PROPN
bioscience-245	116	13	)	)	PUNCT
bioscience-245	116	14	of	of	ADP
bioscience-245	116	15	sod	sod	NOUN
bioscience-245	116	16	in	in	ADP
bioscience-245	116	17	the	the	DET
bioscience-245	116	18	prefrontal	prefrontal	ADJ
bioscience-245	116	19	cortex	cortex	NOUN
bioscience-245	116	20	was	be	AUX
bioscience-245	116	21	decreased	decrease	VERB
bioscience-245	116	22	in	in	ADP
bioscience-245	116	23	the	the	DET
bioscience-245	116	24	depressed	depressed	ADJ
bioscience-245	116	25	group	group	NOUN
bioscience-245	116	26	(	(	PUNCT
bioscience-245	116	27	group	group	NOUN
bioscience-245	116	28	ii	ii	PROPN
bioscience-245	116	29	)	)	PUNCT
bioscience-245	116	30	compared	compare	VERB
bioscience-245	116	31	to	to	ADP
bioscience-245	116	32	the	the	DET
bioscience-245	116	33	control	control	NOUN
bioscience-245	116	34	.	.	PUNCT
bioscience-245	117	1	however	however	ADV
bioscience-245	117	2	,	,	PUNCT
bioscience-245	117	3	vmax	vmax	PROPN
bioscience-245	117	4	increased	increase	VERB
bioscience-245	117	5	in	in	ADP
bioscience-245	117	6	groups	group	NOUN
bioscience-245	117	7	iii	iii	PROPN
bioscience-245	117	8	and	and	CCONJ
bioscience-245	117	9	iv	iv	NUM
bioscience-245	117	10	(	(	PUNCT
bioscience-245	117	11	arginineand	arginineand	ADP
bioscience-245	117	12	fluoxetine	fluoxetine	NOUN
bioscience-245	117	13	-	-	PUNCT
bioscience-245	117	14	treated	treat	VERB
bioscience-245	117	15	groups	group	NOUN
bioscience-245	117	16	,	,	PUNCT
bioscience-245	117	17	respectively	respectively	ADV
bioscience-245	117	18	)	)	PUNCT
bioscience-245	117	19	.	.	PUNCT
bioscience-245	118	1	interestingly	interestingly	ADV
bioscience-245	118	2	,	,	PUNCT
bioscience-245	118	3	the	the	DET
bioscience-245	118	4	michaelis	michaelis	PROPN
bioscience-245	118	5	constant	constant	ADJ
bioscience-245	118	6	(	(	PUNCT
bioscience-245	118	7	km	km	PROPN
bioscience-245	118	8	)	)	PUNCT
bioscience-245	118	9	,	,	PUNCT
bioscience-245	118	10	indicating	indicate	VERB
bioscience-245	118	11	the	the	DET
bioscience-245	118	12	enzyme	enzyme	NOUN
bioscience-245	118	13	’s	’s	PART
bioscience-245	118	14	affinity	affinity	NOUN
bioscience-245	118	15	for	for	ADP
bioscience-245	118	16	its	its	PRON
bioscience-245	118	17	substrate	substrate	NOUN
bioscience-245	118	18	,	,	PUNCT
bioscience-245	118	19	remained	remain	VERB
bioscience-245	118	20	nearly	nearly	ADV
bioscience-245	118	21	unchanged	unchanged	ADJ
bioscience-245	118	22	across	across	ADP
bioscience-245	118	23	all	all	DET
bioscience-245	118	24	groups	group	NOUN
bioscience-245	118	25	.	.	PUNCT
bioscience-245	119	1	similar	similar	ADJ
bioscience-245	119	2	results	result	NOUN
bioscience-245	119	3	were	be	AUX
bioscience-245	119	4	observed	observe	VERB
bioscience-245	119	5	in	in	ADP
bioscience-245	119	6	the	the	DET
bioscience-245	119	7	hippocampus	hippocampus	NOUN
bioscience-245	119	8	figure	figure	NOUN
bioscience-245	119	9	5	5	NUM
bioscience-245	119	10	b.	b.	PROPN
bioscience-245	119	11	(	(	PUNCT
bioscience-245	119	12	note	note	VERB
bioscience-245	119	13	:	:	PUNCT
bioscience-245	119	14	on	on	ADP
bioscience-245	119	15	the	the	DET
bioscience-245	119	16	ordinate	ordinate	NOUN
bioscience-245	119	17	axis	axis	NOUN
bioscience-245	119	18	1	1	NUM
bioscience-245	119	19	/	/	SYM
bioscience-245	119	20	v	v	NOUN
bioscience-245	119	21	;	;	PUNCT
bioscience-245	119	22	on	on	ADP
bioscience-245	119	23	the	the	DET
bioscience-245	119	24	abscissa	abscissa	ADJ
bioscience-245	119	25	axis	axis	NOUN
bioscience-245	119	26	substrate	substrate	NOUN
bioscience-245	119	27	concentration	concentration	NOUN
bioscience-245	119	28	(	(	PUNCT
bioscience-245	119	29	mm	mm	NOUN
bioscience-245	119	30	)	)	PUNCT
bioscience-245	119	31	)	)	PUNCT
bioscience-245	119	32	.	.	PUNCT
bioscience-245	120	1	similar	similar	ADJ
bioscience-245	120	2	results	result	NOUN
bioscience-245	120	3	were	be	AUX
bioscience-245	120	4	obtained	obtain	VERB
bioscience-245	120	5	in	in	ADP
bioscience-245	120	6	the	the	DET
bioscience-245	120	7	study	study	NOUN
bioscience-245	120	8	of	of	ADP
bioscience-245	120	9	the	the	DET
bioscience-245	120	10	kinetic	kinetic	ADJ
bioscience-245	120	11	parameters	parameter	NOUN
bioscience-245	120	12	of	of	ADP
bioscience-245	120	13	the	the	DET
bioscience-245	120	14	enzyme	enzyme	NOUN
bioscience-245	120	15	catalase	catalase	NOUN
bioscience-245	120	16	.	.	PUNCT
bioscience-245	121	1	in	in	ADP
bioscience-245	121	2	particular	particular	ADJ
bioscience-245	121	3	,	,	PUNCT
bioscience-245	121	4	only	only	ADV
bioscience-245	121	5	the	the	DET
bioscience-245	121	6	maximum	maximum	ADJ
bioscience-245	121	7	velocity	velocity	NOUN
bioscience-245	121	8	of	of	ADP
bioscience-245	121	9	the	the	DET
bioscience-245	121	10	enzyme	enzyme	NOUN
bioscience-245	121	11	changed	change	VERB
bioscience-245	121	12	,	,	PUNCT
bioscience-245	121	13	while	while	SCONJ
bioscience-245	121	14	the	the	DET
bioscience-245	121	15	affinity	affinity	NOUN
bioscience-245	121	16	of	of	ADP
bioscience-245	121	17	the	the	DET
bioscience-245	121	18	enzyme	enzyme	NOUN
bioscience-245	121	19	for	for	ADP
bioscience-245	121	20	the	the	DET
bioscience-245	121	21	substrate	substrate	NOUN
bioscience-245	121	22	(	(	PUNCT
bioscience-245	121	23	h2o2	h2o2	NOUN
bioscience-245	121	24	)	)	PUNCT
bioscience-245	121	25	remained	remain	VERB
bioscience-245	121	26	the	the	DET
bioscience-245	121	27	same	same	ADJ
bioscience-245	121	28	figure	figure	NOUN
bioscience-245	121	29	6	6	NUM
bioscience-245	121	30	.	.	PUNCT
bioscience-245	122	1	discussion	discussion	NOUN
bioscience-245	122	2	this	this	DET
bioscience-245	122	3	study	study	NOUN
bioscience-245	122	4	aimed	aim	VERB
bioscience-245	122	5	to	to	PART
bioscience-245	122	6	investigate	investigate	VERB
bioscience-245	122	7	the	the	DET
bioscience-245	122	8	effect	effect	NOUN
bioscience-245	122	9	of	of	ADP
bioscience-245	122	10	exogenous	exogenous	ADJ
bioscience-245	122	11	larginine	larginine	NOUN
bioscience-245	122	12	on	on	ADP
bioscience-245	122	13	corticosterone	corticosterone	NOUN
bioscience-245	122	14	-	-	PUNCT
bioscience-245	122	15	induced	induce	VERB
bioscience-245	122	16	depression	depression	NOUN
bioscience-245	122	17	in	in	ADP
bioscience-245	122	18	albino	albino	NOUN
bioscience-245	122	19	rats	rat	NOUN
bioscience-245	122	20	.	.	PUNCT
bioscience-245	123	1	our	our	PRON
bioscience-245	123	2	findings	finding	NOUN
bioscience-245	123	3	demonstrate	demonstrate	VERB
bioscience-245	123	4	that	that	SCONJ
bioscience-245	123	5	daily	daily	PROPN
bioscience-245	123	6	administration	administration	NOUN
bioscience-245	123	7	of	of	ADP
bioscience-245	123	8	l	l	NOUN
bioscience-245	123	9	-	-	NOUN
bioscience-245	123	10	arginine	arginine	NOUN
bioscience-245	123	11	(	(	PUNCT
bioscience-245	123	12	150	150	NUM
bioscience-245	123	13	mg	mg	NUM
bioscience-245	123	14	/	/	SYM
bioscience-245	123	15	kg	kg	NOUN
bioscience-245	123	16	)	)	PUNCT
bioscience-245	123	17	for	for	ADP
bioscience-245	123	18	14	14	NUM
bioscience-245	123	19	days	day	NOUN
bioscience-245	123	20	leads	lead	VERB
bioscience-245	123	21	to	to	ADP
bioscience-245	123	22	improvements	improvement	NOUN
bioscience-245	123	23	in	in	ADP
bioscience-245	123	24	behavioral	behavioral	ADJ
bioscience-245	123	25	and	and	CCONJ
bioscience-245	123	26	physiological	physiological	ADJ
bioscience-245	123	27	parameters	parameter	NOUN
bioscience-245	123	28	associated	associate	VERB
bioscience-245	123	29	with	with	ADP
bioscience-245	123	30	depression	depression	NOUN
bioscience-245	123	31	.	.	PUNCT
bioscience-245	124	1	notably	notably	ADV
bioscience-245	124	2	,	,	PUNCT
bioscience-245	124	3	the	the	DET
bioscience-245	124	4	open	open	ADJ
bioscience-245	124	5	-	-	PUNCT
bioscience-245	124	6	field	field	NOUN
bioscience-245	124	7	test	test	NOUN
bioscience-245	124	8	results	result	NOUN
bioscience-245	124	9	showed	show	VERB
bioscience-245	124	10	enhanced	enhanced	ADJ
bioscience-245	124	11	locomotor	locomotor	NOUN
bioscience-245	124	12	activity	activity	NOUN
bioscience-245	124	13	table	table	NOUN
bioscience-245	124	14	1	1	NUM
bioscience-245	124	15	,	,	PUNCT
bioscience-245	124	16	while	while	SCONJ
bioscience-245	124	17	improvements	improvement	NOUN
bioscience-245	124	18	in	in	ADP
bioscience-245	124	19	forced	force	VERB
bioscience-245	124	20	swim	swim	NOUN
bioscience-245	124	21	test	test	NOUN
bioscience-245	124	22	(	(	PUNCT
bioscience-245	124	23	fst	fst	NOUN
bioscience-245	124	24	)	)	PUNCT
bioscience-245	124	25	and	and	CCONJ
bioscience-245	124	26	tail	tail	NOUN
bioscience-245	124	27	suspension	suspension	NOUN
bioscience-245	124	28	test	test	NOUN
bioscience-245	124	29	(	(	PUNCT
bioscience-245	124	30	tst	tst	NOUN
bioscience-245	124	31	)	)	PUNCT
bioscience-245	124	32	parameters	parameter	NOUN
bioscience-245	124	33	further	far	ADV
bioscience-245	124	34	supported	support	VERB
bioscience-245	124	35	its	its	PRON
bioscience-245	124	36	antidepressant	antidepressant	ADJ
bioscience-245	124	37	-	-	PUNCT
bioscience-245	124	38	like	like	ADJ
bioscience-245	124	39	effects	effect	NOUN
bioscience-245	124	40	,	,	PUNCT
bioscience-245	124	41	in	in	ADP
bioscience-245	124	42	agreement	agreement	NOUN
bioscience-245	124	43	with	with	ADP
bioscience-245	124	44	existing	exist	VERB
bioscience-245	124	45	literature	literature	NOUN
bioscience-245	125	1	[	[	X
bioscience-245	125	2	21	21	NUM
bioscience-245	125	3	]	]	PUNCT
bioscience-245	125	4	.	.	PUNCT
bioscience-245	126	1	serotonin	serotonin	VERB
bioscience-245	126	2	,	,	PUNCT
bioscience-245	126	3	a	a	DET
bioscience-245	126	4	key	key	ADJ
bioscience-245	126	5	neurotransmitter	neurotransmitter	NOUN
bioscience-245	126	6	,	,	PUNCT
bioscience-245	126	7	plays	play	VERB
bioscience-245	126	8	a	a	DET
bioscience-245	126	9	critical	critical	ADJ
bioscience-245	126	10	role	role	NOUN
bioscience-245	126	11	in	in	ADP
bioscience-245	126	12	the	the	DET
bioscience-245	126	13	pathophysiology	pathophysiology	NOUN
bioscience-245	126	14	of	of	ADP
bioscience-245	126	15	depression	depression	NOUN
bioscience-245	126	16	,	,	PUNCT
bioscience-245	126	17	as	as	SCONJ
bioscience-245	126	18	evidenced	evidence	VERB
bioscience-245	126	19	by	by	ADP
bioscience-245	126	20	the	the	DET
bioscience-245	126	21	efficacy	efficacy	NOUN
bioscience-245	126	22	of	of	ADP
bioscience-245	126	23	selective	selective	ADJ
bioscience-245	126	24	serotonin	serotonin	NOUN
bioscience-245	126	25	reuptake	reuptake	NOUN
bioscience-245	126	26	inhibitors	inhibitor	NOUN
bioscience-245	126	27	(	(	PUNCT
bioscience-245	126	28	ssris	ssris	NOUN
bioscience-245	126	29	)	)	PUNCT
bioscience-245	127	1	[	[	X
bioscience-245	127	2	8	8	NUM
bioscience-245	127	3	;	;	PUNCT
bioscience-245	127	4	9	9	NUM
bioscience-245	127	5	;	;	PUNCT
bioscience-245	127	6	22	22	NUM
bioscience-245	127	7	]	]	PUNCT
bioscience-245	127	8	.	.	PUNCT
bioscience-245	128	1	to	to	PART
bioscience-245	128	2	clarify	clarify	VERB
bioscience-245	128	3	the	the	DET
bioscience-245	128	4	mechanism	mechanism	NOUN
bioscience-245	128	5	underlying	underlie	VERB
bioscience-245	128	6	the	the	DET
bioscience-245	128	7	observed	observed	ADJ
bioscience-245	128	8	effects	effect	NOUN
bioscience-245	128	9	,	,	PUNCT
bioscience-245	128	10	we	we	PRON
bioscience-245	128	11	measured	measure	VERB
bioscience-245	128	12	serotonin	serotonin	NOUN
bioscience-245	128	13	levels	level	NOUN
bioscience-245	128	14	in	in	ADP
bioscience-245	128	15	the	the	DET
bioscience-245	128	16	prefrontal	prefrontal	ADJ
bioscience-245	128	17	cortex	cortex	NOUN
bioscience-245	128	18	and	and	CCONJ
bioscience-245	128	19	hippocampus	hippocampus	NOUN
bioscience-245	128	20	.	.	PUNCT
bioscience-245	129	1	l	l	NOUN
bioscience-245	129	2	-	-	PUNCT
bioscience-245	129	3	arginine	arginine	NOUN
bioscience-245	129	4	supplementation	supplementation	NOUN
bioscience-245	129	5	significantly	significantly	ADV
bioscience-245	129	6	increased	increase	VERB
bioscience-245	129	7	serotonin	serotonin	NOUN
bioscience-245	129	8	levels	level	NOUN
bioscience-245	129	9	in	in	ADP
bioscience-245	129	10	both	both	DET
bioscience-245	129	11	regions	region	NOUN
bioscience-245	129	12	,	,	PUNCT
bioscience-245	129	13	closely	closely	ADV
bioscience-245	129	14	resembling	resemble	VERB
bioscience-245	129	15	the	the	DET
bioscience-245	129	16	effects	effect	NOUN
bioscience-245	129	17	of	of	ADP
bioscience-245	129	18	fluoxetine	fluoxetine	NOUN
bioscience-245	129	19	table	table	NOUN
bioscience-245	129	20	2	2	NUM
bioscience-245	129	21	.	.	PUNCT
bioscience-245	130	1	this	this	PRON
bioscience-245	130	2	suggests	suggest	VERB
bioscience-245	130	3	that	that	SCONJ
bioscience-245	130	4	the	the	DET
bioscience-245	130	5	antidepressant	antidepressant	ADJ
bioscience-245	130	6	-	-	PUNCT
bioscience-245	130	7	like	like	ADJ
bioscience-245	130	8	activity	activity	NOUN
bioscience-245	130	9	of	of	ADP
bioscience-245	130	10	l	l	NOUN
bioscience-245	130	11	-	-	NOUN
bioscience-245	130	12	arginine	arginine	NOUN
bioscience-245	130	13	may	may	AUX
bioscience-245	130	14	be	be	AUX
bioscience-245	130	15	,	,	PUNCT
bioscience-245	130	16	at	at	ADP
bioscience-245	130	17	least	least	ADJ
bioscience-245	130	18	in	in	ADP
bioscience-245	130	19	part	part	NOUN
bioscience-245	130	20	,	,	PUNCT
bioscience-245	130	21	serotonin	serotonin	NOUN
bioscience-245	130	22	-	-	PUNCT
bioscience-245	130	23	mediated	mediate	VERB
bioscience-245	130	24	.	.	PUNCT
bioscience-245	131	1	serotonin	serotonin	VERB
bioscience-245	131	2	also	also	ADV
bioscience-245	131	3	exhibits	exhibit	VERB
bioscience-245	131	4	strong	strong	ADJ
bioscience-245	131	5	antioxidant	antioxidant	ADJ
bioscience-245	131	6	properties	property	NOUN
bioscience-245	131	7	.	.	PUNCT
bioscience-245	132	1	a	a	DET
bioscience-245	132	2	decrease	decrease	NOUN
bioscience-245	132	3	in	in	ADP
bioscience-245	132	4	serotonin	serotonin	NOUN
bioscience-245	132	5	levels	level	NOUN
bioscience-245	132	6	,	,	PUNCT
bioscience-245	132	7	as	as	SCONJ
bioscience-245	132	8	observed	observe	VERB
bioscience-245	132	9	in	in	ADP
bioscience-245	132	10	depression	depression	NOUN
bioscience-245	132	11	,	,	PUNCT
bioscience-245	132	12	is	be	AUX
bioscience-245	132	13	associated	associate	VERB
bioscience-245	132	14	with	with	ADP
bioscience-245	132	15	reduced	reduced	ADJ
bioscience-245	132	16	antioxidant	antioxidant	ADJ
bioscience-245	132	17	defense	defense	NOUN
bioscience-245	132	18	and	and	CCONJ
bioscience-245	132	19	elevated	elevated	ADJ
bioscience-245	132	20	oxidative	oxidative	ADJ
bioscience-245	132	21	stress	stress	NOUN
bioscience-245	132	22	markers	marker	NOUN
bioscience-245	132	23	such	such	ADJ
bioscience-245	132	24	as	as	ADP
bioscience-245	132	25	malondialdehyde	malondialdehyde	PROPN
bioscience-245	132	26	(	(	PUNCT
bioscience-245	132	27	mda	mda	PROPN
bioscience-245	132	28	)	)	PUNCT
bioscience-245	132	29	and	and	CCONJ
bioscience-245	132	30	nitric	nitric	ADJ
bioscience-245	132	31	oxide	oxide	NOUN
bioscience-245	132	32	(	(	PUNCT
bioscience-245	132	33	no	no	NOUN
bioscience-245	132	34	)	)	PUNCT
bioscience-245	132	35	,	,	PUNCT
bioscience-245	132	36	along	along	ADP
bioscience-245	132	37	with	with	ADP
bioscience-245	132	38	decreased	decrease	VERB
bioscience-245	132	39	activity	activity	NOUN
bioscience-245	132	40	of	of	ADP
bioscience-245	132	41	antioxidant	antioxidant	ADJ
bioscience-245	132	42	enzymes	enzyme	NOUN
bioscience-245	132	43	like	like	ADP
bioscience-245	132	44	glutathione	glutathione	NOUN
bioscience-245	132	45	peroxidase	peroxidase	NOUN
bioscience-245	132	46	,	,	PUNCT
bioscience-245	132	47	superoxide	superoxide	NOUN
bioscience-245	132	48	dismutase	dismutase	NOUN
bioscience-245	132	49	(	(	PUNCT
bioscience-245	132	50	sod	sod	NOUN
bioscience-245	132	51	)	)	PUNCT
bioscience-245	132	52	,	,	PUNCT
bioscience-245	132	53	and	and	CCONJ
bioscience-245	132	54	catalase	catalase	VERB
bioscience-245	132	55	hence	hence	ADV
bioscience-245	132	56	,	,	PUNCT
bioscience-245	132	57	restoring	restore	VERB
bioscience-245	132	58	serotonin	serotonin	NOUN
bioscience-245	132	59	levelseither	levelseither	NOUN
bioscience-245	132	60	pharmacologically	pharmacologically	ADV
bioscience-245	132	61	(	(	PUNCT
bioscience-245	132	62	e.g.	e.g.	ADV
bioscience-245	132	63	,	,	PUNCT
bioscience-245	132	64	fluoxetine	fluoxetine	NOUN
bioscience-245	132	65	)	)	PUNCT
bioscience-245	132	66	or	or	CCONJ
bioscience-245	132	67	via	via	ADP
bioscience-245	132	68	l	l	NOUN
bioscience-245	132	69	-	-	NOUN
bioscience-245	132	70	arginine	arginine	NOUN
bioscience-245	132	71	supplementationcan	supplementationcan	NOUN
bioscience-245	132	72	reduce	reduce	VERB
bioscience-245	132	73	oxidative	oxidative	ADJ
bioscience-245	132	74	stress	stress	NOUN
bioscience-245	132	75	in	in	ADP
bioscience-245	132	76	the	the	DET
bioscience-245	132	77	brain	brain	NOUN
bioscience-245	133	1	[	[	X
bioscience-245	133	2	22	22	NUM
bioscience-245	133	3	;	;	PUNCT
bioscience-245	133	4	23	23	NUM
bioscience-245	133	5	;	;	PUNCT
bioscience-245	133	6	24	24	NUM
bioscience-245	133	7	]	]	PUNCT
bioscience-245	133	8	.	.	PUNCT
bioscience-245	134	1	in	in	ADP
bioscience-245	134	2	this	this	DET
bioscience-245	134	3	study	study	NOUN
bioscience-245	134	4	,	,	PUNCT
bioscience-245	134	5	we	we	PRON
bioscience-245	134	6	observed	observe	VERB
bioscience-245	134	7	decreased	decrease	VERB
bioscience-245	134	8	mda	mda	PROPN
bioscience-245	134	9	and	and	CCONJ
bioscience-245	134	10	no	no	DET
bioscience-245	134	11	levels	level	NOUN
bioscience-245	134	12	following	follow	VERB
bioscience-245	134	13	l	l	NOUN
bioscience-245	134	14	-	-	PUNCT
bioscience-245	134	15	arginine	arginine	NOUN
bioscience-245	134	16	administration	administration	NOUN
bioscience-245	134	17	figure	figure	NOUN
bioscience-245	134	18	3	3	NUM
bioscience-245	134	19	,	,	PUNCT
bioscience-245	134	20	suggesting	suggest	VERB
bioscience-245	134	21	a	a	DET
bioscience-245	134	22	reduction	reduction	NOUN
bioscience-245	134	23	in	in	ADP
bioscience-245	134	24	lipid	lipid	NOUN
bioscience-245	134	25	peroxidation	peroxidation	NOUN
bioscience-245	134	26	and	and	CCONJ
bioscience-245	134	27	nitrosative	nitrosative	ADJ
bioscience-245	134	28	stress	stress	NOUN
bioscience-245	134	29	.	.	PUNCT
bioscience-245	135	1	these	these	DET
bioscience-245	135	2	results	result	NOUN
bioscience-245	135	3	support	support	VERB
bioscience-245	135	4	the	the	DET
bioscience-245	135	5	notion	notion	NOUN
bioscience-245	135	6	that	that	SCONJ
bioscience-245	135	7	the	the	DET
bioscience-245	135	8	antidepressant	antidepressant	ADJ
bioscience-245	135	9	-	-	PUNCT
bioscience-245	135	10	like	like	ADJ
bioscience-245	135	11	effect	effect	NOUN
bioscience-245	135	12	of	of	ADP
bioscience-245	135	13	l	l	NOUN
bioscience-245	135	14	-	-	NOUN
bioscience-245	135	15	arginine	arginine	NOUN
bioscience-245	135	16	is	be	AUX
bioscience-245	135	17	mediated	mediate	VERB
bioscience-245	135	18	not	not	PART
bioscience-245	135	19	only	only	ADV
bioscience-245	135	20	by	by	ADP
bioscience-245	135	21	serotonin	serotonin	NOUN
bioscience-245	135	22	enhancement	enhancement	NOUN
bioscience-245	135	23	but	but	CCONJ
bioscience-245	135	24	also	also	ADV
bioscience-245	135	25	by	by	ADP
bioscience-245	135	26	attenuation	attenuation	NOUN
bioscience-245	135	27	of	of	ADP
bioscience-245	135	28	oxidative	oxidative	ADJ
bioscience-245	135	29	stress	stress	NOUN
bioscience-245	135	30	[	[	X
bioscience-245	135	31	25	25	NUM
bioscience-245	135	32	]	]	PUNCT
bioscience-245	135	33	.	.	PUNCT
bioscience-245	136	1	furthermore	furthermore	ADV
bioscience-245	136	2	,	,	PUNCT
bioscience-245	136	3	we	we	PRON
bioscience-245	136	4	evaluated	evaluate	VERB
bioscience-245	136	5	the	the	DET
bioscience-245	136	6	impact	impact	NOUN
bioscience-245	136	7	of	of	ADP
bioscience-245	136	8	l	l	NOUN
bioscience-245	136	9	-	-	NOUN
bioscience-245	136	10	arginine	arginine	NOUN
bioscience-245	136	11	on	on	ADP
bioscience-245	136	12	antioxidant	antioxidant	ADJ
bioscience-245	136	13	enzyme	enzyme	NOUN
bioscience-245	136	14	activity	activity	NOUN
bioscience-245	136	15	.	.	PUNCT
bioscience-245	137	1	corticosterone	corticosterone	NOUN
bioscience-245	137	2	-	-	PUNCT
bioscience-245	137	3	induced	induce	VERB
bioscience-245	137	4	depression	depression	NOUN
bioscience-245	137	5	significantly	significantly	ADV
bioscience-245	137	6	reduced	reduce	VERB
bioscience-245	137	7	sod	sod	NOUN
bioscience-245	137	8	and	and	CCONJ
bioscience-245	137	9	catalase	catalase	NOUN
bioscience-245	137	10	activities	activity	NOUN
bioscience-245	137	11	figure	figure	VERB
bioscience-245	137	12	4	4	NUM
bioscience-245	137	13	,	,	PUNCT
bioscience-245	137	14	consistent	consistent	ADJ
bioscience-245	137	15	with	with	ADP
bioscience-245	137	16	previous	previous	ADJ
bioscience-245	137	17	reports	report	NOUN
bioscience-245	137	18	[	[	X
bioscience-245	137	19	26	26	NUM
bioscience-245	137	20	;	;	PUNCT
bioscience-245	137	21	27	27	NUM
bioscience-245	137	22	]	]	PUNCT
bioscience-245	137	23	.	.	PUNCT
bioscience-245	138	1	l	l	NOUN
bioscience-245	138	2	-	-	PUNCT
bioscience-245	138	3	arginine	arginine	NOUN
bioscience-245	138	4	administration	administration	NOUN
bioscience-245	138	5	restored	restore	VERB
bioscience-245	138	6	these	these	DET
bioscience-245	138	7	activities	activity	NOUN
bioscience-245	138	8	,	,	PUNCT
bioscience-245	138	9	comparable	comparable	ADJ
bioscience-245	138	10	to	to	ADP
bioscience-245	138	11	the	the	DET
bioscience-245	138	12	effects	effect	NOUN
bioscience-245	138	13	observed	observe	VERB
bioscience-245	138	14	with	with	ADP
bioscience-245	138	15	fluoxetine	fluoxetine	NOUN
bioscience-245	138	16	.	.	PUNCT
bioscience-245	139	1	to	to	PART
bioscience-245	139	2	understand	understand	VERB
bioscience-245	139	3	the	the	DET
bioscience-245	139	4	mechanism	mechanism	NOUN
bioscience-245	139	5	behind	behind	ADP
bioscience-245	139	6	these	these	DET
bioscience-245	139	7	changes	change	NOUN
bioscience-245	139	8	,	,	PUNCT
bioscience-245	139	9	we	we	PRON
bioscience-245	139	10	analyzed	analyze	VERB
bioscience-245	139	11	kinetic	kinetic	ADJ
bioscience-245	139	12	parameters	parameter	NOUN
bioscience-245	139	13	(	(	PUNCT
bioscience-245	139	14	vmax	vmax	PROPN
bioscience-245	139	15	and	and	CCONJ
bioscience-245	139	16	km	km	PROPN
bioscience-245	139	17	)	)	PUNCT
bioscience-245	139	18	of	of	ADP
bioscience-245	139	19	sod	sod	NOUN
bioscience-245	139	20	and	and	CCONJ
bioscience-245	139	21	catalase	catalase	NOUN
bioscience-245	139	22	.	.	PUNCT
bioscience-245	140	1	in	in	ADP
bioscience-245	140	2	corticosterone	corticosterone	NOUN
bioscience-245	140	3	-	-	PUNCT
bioscience-245	140	4	treated	treat	VERB
bioscience-245	140	5	rats	rat	NOUN
bioscience-245	140	6	,	,	PUNCT
bioscience-245	140	7	both	both	CCONJ
bioscience-245	140	8	vmax	vmax	NOUN
bioscience-245	140	9	and	and	CCONJ
bioscience-245	140	10	substrate	substrate	NOUN
bioscience-245	140	11	affinity	affinity	NOUN
bioscience-245	140	12	(	(	PUNCT
bioscience-245	140	13	km	km	NOUN
bioscience-245	140	14	)	)	PUNCT
bioscience-245	140	15	of	of	ADP
bioscience-245	140	16	the	the	DET
bioscience-245	140	17	enzymes	enzyme	NOUN
bioscience-245	140	18	were	be	AUX
bioscience-245	140	19	reduced	reduce	VERB
bioscience-245	140	20	.	.	PUNCT
bioscience-245	141	1	however	however	ADV
bioscience-245	141	2	,	,	PUNCT
bioscience-245	141	3	l	l	NOUN
bioscience-245	141	4	-	-	NOUN
bioscience-245	141	5	arginine	arginine	NOUN
bioscience-245	141	6	and	and	CCONJ
bioscience-245	141	7	fluoxetine	fluoxetine	NOUN
bioscience-245	141	8	treatments	treatment	NOUN
bioscience-245	141	9	produced	produce	VERB
bioscience-245	141	10	divergent	divergent	ADJ
bioscience-245	141	11	outcomes	outcome	NOUN
bioscience-245	141	12	.	.	PUNCT
bioscience-245	142	1	fluoxetine	fluoxetine	PROPN
bioscience-245	142	2	increased	increase	VERB
bioscience-245	142	3	both	both	CCONJ
bioscience-245	142	4	vmax	vmax	NOUN
bioscience-245	142	5	and	and	CCONJ
bioscience-245	142	6	substrate	substrate	NOUN
bioscience-245	142	7	affinity	affinity	NOUN
bioscience-245	142	8	figure	figure	NOUN
bioscience-245	142	9	5	5	NUM
bioscience-245	142	10	,	,	PUNCT
bioscience-245	142	11	suggesting	suggest	VERB
bioscience-245	142	12	alterations	alteration	NOUN
bioscience-245	142	13	in	in	ADP
bioscience-245	142	14	both	both	DET
bioscience-245	142	15	enzyme	enzyme	NOUN
bioscience-245	142	16	expression	expression	NOUN
bioscience-245	142	17	and	and	CCONJ
bioscience-245	142	18	structure	structure	NOUN
bioscience-245	142	19	.	.	PUNCT
bioscience-245	143	1	these	these	DET
bioscience-245	143	2	findings	finding	NOUN
bioscience-245	143	3	align	align	VERB
bioscience-245	143	4	with	with	ADP
bioscience-245	143	5	literature	literature	NOUN
bioscience-245	143	6	indicating	indicate	VERB
bioscience-245	143	7	that	that	SCONJ
bioscience-245	143	8	fluoxetines	fluoxetine	VERB
bioscience-245	143	9	antioxidant	antioxidant	ADJ
bioscience-245	143	10	effects	effect	NOUN
bioscience-245	143	11	may	may	AUX
bioscience-245	143	12	extend	extend	VERB
bioscience-245	143	13	beyond	beyond	ADP
bioscience-245	143	14	serotonin	serotonin	NOUN
bioscience-245	143	15	modulation	modulation	NOUN
bioscience-245	143	16	,	,	PUNCT
bioscience-245	143	17	potentially	potentially	ADV
bioscience-245	143	18	involving	involve	VERB
bioscience-245	143	19	direct	direct	ADJ
bioscience-245	143	20	ros	ro	NOUN
bioscience-245	143	21	scavenging	scavenge	VERB
bioscience-245	143	22	[	[	X
bioscience-245	143	23	28	28	NUM
bioscience-245	143	24	;	;	PUNCT
bioscience-245	143	25	29	29	NUM
bioscience-245	143	26	]	]	PUNCT
bioscience-245	143	27	.	.	PUNCT
bioscience-245	144	1	conversely	conversely	ADV
bioscience-245	144	2	,	,	PUNCT
bioscience-245	144	3	l	l	NOUN
bioscience-245	144	4	-	-	PUNCT
bioscience-245	144	5	arginine	arginine	NOUN
bioscience-245	144	6	administration	administration	NOUN
bioscience-245	144	7	led	lead	VERB
bioscience-245	144	8	to	to	ADP
bioscience-245	144	9	increased	increase	VERB
bioscience-245	144	10	vmax	vmax	PROPN
bioscience-245	144	11	without	without	ADP
bioscience-245	144	12	altering	alter	VERB
bioscience-245	144	13	km	km	NOUN
bioscience-245	144	14	,	,	PUNCT
bioscience-245	144	15	indicating	indicate	VERB
bioscience-245	144	16	an	an	DET
bioscience-245	144	17	upregulation	upregulation	NOUN
bioscience-245	144	18	in	in	ADP
bioscience-245	144	19	enzyme	enzyme	NOUN
bioscience-245	144	20	quantity	quantity	NOUN
bioscience-245	144	21	rather	rather	ADV
bioscience-245	144	22	than	than	ADP
bioscience-245	144	23	structural	structural	ADJ
bioscience-245	144	24	modifications	modification	NOUN
bioscience-245	144	25	.	.	PUNCT
bioscience-245	145	1	these	these	DET
bioscience-245	145	2	changes	change	NOUN
bioscience-245	145	3	suggest	suggest	VERB
bioscience-245	145	4	that	that	SCONJ
bioscience-245	145	5	l	l	NOUN
bioscience-245	145	6	-	-	PUNCT
bioscience-245	145	7	arginine	arginine	NOUN
bioscience-245	145	8	stimulates	stimulate	VERB
bioscience-245	145	9	enzyme	enzyme	NOUN
bioscience-245	145	10	synthesis	synthesis	NOUN
bioscience-245	145	11	figures	figure	NOUN
bioscience-245	145	12	5	5	NUM
bioscience-245	145	13	,	,	PUNCT
bioscience-245	145	14	6	6	NUM
bioscience-245	145	15	,	,	PUNCT
bioscience-245	145	16	enhancing	enhance	VERB
bioscience-245	145	17	antioxidant	antioxidant	ADJ
bioscience-245	145	18	capacity	capacity	NOUN
bioscience-245	145	19	via	via	ADP
bioscience-245	145	20	increased	increase	VERB
bioscience-245	145	21	enzyme	enzyme	NOUN
bioscience-245	145	22	availability	availability	NOUN
bioscience-245	145	23	rather	rather	ADV
bioscience-245	145	24	than	than	ADP
bioscience-245	145	25	altered	alter	VERB
bioscience-245	145	26	binding	bind	VERB
bioscience-245	145	27	properties	property	NOUN
bioscience-245	145	28	.	.	PUNCT
bioscience-245	146	1	mitochondrial	mitochondrial	ADJ
bioscience-245	146	2	dysfunction	dysfunction	NOUN
bioscience-245	146	3	and	and	CCONJ
bioscience-245	146	4	atp	atp	PROPN
bioscience-245	146	5	depletion	depletion	NOUN
bioscience-245	146	6	are	be	AUX
bioscience-245	146	7	well	well	ADV
bioscience-245	146	8	-	-	PUNCT
bioscience-245	146	9	documented	document	VERB
bioscience-245	146	10	in	in	ADP
bioscience-245	146	11	depression	depression	NOUN
bioscience-245	146	12	and	and	CCONJ
bioscience-245	146	13	contribute	contribute	VERB
bioscience-245	146	14	to	to	ADP
bioscience-245	146	15	impaired	impaired	ADJ
bioscience-245	146	16	neuronal	neuronal	ADJ
bioscience-245	146	17	function	function	NOUN
bioscience-245	146	18	and	and	CCONJ
bioscience-245	146	19	synaptic	synaptic	ADJ
bioscience-245	146	20	plasticity	plasticity	NOUN
bioscience-245	146	21	.	.	PUNCT
bioscience-245	147	1	l	l	NOUN
bioscience-245	147	2	-	-	NOUN
bioscience-245	147	3	arginine	arginine	NOUN
bioscience-245	147	4	is	be	AUX
bioscience-245	147	5	a	a	DET
bioscience-245	147	6	precursor	precursor	NOUN
bioscience-245	147	7	for	for	ADP
bioscience-245	147	8	several	several	ADJ
bioscience-245	147	9	metabolites	metabolite	NOUN
bioscience-245	147	10	,	,	PUNCT
bioscience-245	147	11	including	include	VERB
bioscience-245	147	12	creatine	creatine	NOUN
bioscience-245	147	13	,	,	PUNCT
bioscience-245	147	14	which	which	PRON
bioscience-245	147	15	plays	play	VERB
bioscience-245	147	16	a	a	DET
bioscience-245	147	17	crucial	crucial	ADJ
bioscience-245	147	18	role	role	NOUN
bioscience-245	147	19	in	in	ADP
bioscience-245	147	20	energy	energy	NOUN
bioscience-245	147	21	metabolism	metabolism	NOUN
bioscience-245	147	22	[	[	X
bioscience-245	147	23	30	30	NUM
bioscience-245	147	24	;	;	PUNCT
bioscience-245	147	25	31	31	NUM
bioscience-245	147	26	]	]	PUNCT
bioscience-245	147	27	.	.	PUNCT
bioscience-245	148	1	therefore	therefore	ADV
bioscience-245	148	2	,	,	PUNCT
bioscience-245	148	3	the	the	DET
bioscience-245	148	4	observed	observed	ADJ
bioscience-245	148	5	effects	effect	NOUN
bioscience-245	148	6	of	of	ADP
bioscience-245	148	7	l	l	NOUN
bioscience-245	148	8	-	-	NOUN
bioscience-245	148	9	arginine	arginine	NOUN
bioscience-245	148	10	may	may	AUX
bioscience-245	148	11	also	also	ADV
bioscience-245	148	12	be	be	AUX
bioscience-245	148	13	linked	link	VERB
bioscience-245	148	14	to	to	ADP
bioscience-245	148	15	its	its	PRON
bioscience-245	148	16	role	role	NOUN
bioscience-245	148	17	in	in	ADP
bioscience-245	148	18	restoring	restore	VERB
bioscience-245	148	19	cellular	cellular	ADJ
bioscience-245	148	20	energy	energy	NOUN
bioscience-245	148	21	homeostasis	homeostasis	NOUN
bioscience-245	148	22	,	,	PUNCT
bioscience-245	148	23	which	which	PRON
bioscience-245	148	24	is	be	AUX
bioscience-245	148	25	often	often	ADV
bioscience-245	148	26	compromised	compromise	VERB
bioscience-245	148	27	during	during	ADP
bioscience-245	148	28	depression	depression	NOUN
bioscience-245	148	29	.	.	PUNCT
bioscience-245	149	1	highlights	highlight	NOUN
bioscience-245	149	2	in	in	ADP
bioscience-245	149	3	bioscience	bioscience	NOUN
bioscience-245	149	4	page	page	NOUN
bioscience-245	149	5	5	5	NUM
bioscience-245	149	6	of	of	ADP
bioscience-245	149	7	7	7	NUM
bioscience-245	149	8	june	june	PROPN
bioscience-245	149	9	2025|volume	2025|volume	NUM
bioscience-245	149	10	8	8	NUM
bioscience-245	149	11	http://bioscience.highlightsin.org/	http://bioscience.highlightsin.org/	NOUN
bioscience-245	149	12	mantashashvili	mantashashvili	NOUN
bioscience-245	150	1	t	t	PROPN
bioscience-245	150	2	et	et	PROPN
bioscience-245	150	3	al	al	PROPN
bioscience-245	150	4	.	.	PROPN
bioscience-245	150	5	,	,	PUNCT
bioscience-245	150	6	2025	2025	NUM
bioscience-245	150	7	l	l	NOUN
bioscience-245	150	8	-	-	NOUN
bioscience-245	150	9	arginine	arginine	NOUN
bioscience-245	150	10	as	as	ADP
bioscience-245	150	11	a	a	DET
bioscience-245	150	12	potential	potential	ADJ
bioscience-245	150	13	antidepressant	antidepressant	NOUN
bioscience-245	150	14	:	:	PUNCT
bioscience-245	150	15	effects	effect	NOUN
bioscience-245	150	16	on	on	ADP
bioscience-245	150	17	cognitive	cognitive	ADJ
bioscience-245	150	18	function	function	NOUN
bioscience-245	150	19	conclusion	conclusion	NOUN
bioscience-245	150	20	depression	depression	NOUN
bioscience-245	150	21	is	be	AUX
bioscience-245	150	22	a	a	DET
bioscience-245	150	23	prevalent	prevalent	ADJ
bioscience-245	150	24	and	and	CCONJ
bioscience-245	150	25	debilitating	debilitate	VERB
bioscience-245	150	26	psychiatric	psychiatric	ADJ
bioscience-245	150	27	disorder	disorder	NOUN
bioscience-245	150	28	with	with	ADP
bioscience-245	150	29	profound	profound	ADJ
bioscience-245	150	30	implications	implication	NOUN
bioscience-245	150	31	for	for	ADP
bioscience-245	150	32	individual	individual	ADJ
bioscience-245	150	33	well	well	ADV
bioscience-245	150	34	-	-	PUNCT
bioscience-245	150	35	being	being	NOUN
bioscience-245	150	36	and	and	CCONJ
bioscience-245	150	37	societal	societal	ADJ
bioscience-245	150	38	productivity	productivity	NOUN
bioscience-245	150	39	.	.	PUNCT
bioscience-245	151	1	the	the	DET
bioscience-245	151	2	current	current	ADJ
bioscience-245	151	3	study	study	NOUN
bioscience-245	151	4	provides	provide	VERB
bioscience-245	151	5	compelling	compelling	ADJ
bioscience-245	151	6	evidence	evidence	NOUN
bioscience-245	151	7	for	for	ADP
bioscience-245	151	8	the	the	DET
bioscience-245	151	9	antidepressant	antidepressant	ADJ
bioscience-245	151	10	-	-	PUNCT
bioscience-245	151	11	like	like	ADJ
bioscience-245	151	12	effects	effect	NOUN
bioscience-245	151	13	of	of	ADP
bioscience-245	151	14	l	l	NOUN
bioscience-245	151	15	-	-	NOUN
bioscience-245	151	16	arginine	arginine	NOUN
bioscience-245	151	17	in	in	ADP
bioscience-245	151	18	a	a	DET
bioscience-245	151	19	corticosterone	corticosterone	NOUN
bioscience-245	151	20	-	-	PUNCT
bioscience-245	151	21	induced	induce	VERB
bioscience-245	151	22	model	model	NOUN
bioscience-245	151	23	of	of	ADP
bioscience-245	151	24	depression	depression	NOUN
bioscience-245	151	25	.	.	PUNCT
bioscience-245	152	1	l	l	NOUN
bioscience-245	152	2	-	-	PUNCT
bioscience-245	152	3	arginine	arginine	NOUN
bioscience-245	152	4	supplementation	supplementation	NOUN
bioscience-245	152	5	significantly	significantly	ADV
bioscience-245	152	6	improved	improve	VERB
bioscience-245	152	7	behavioral	behavioral	ADJ
bioscience-245	152	8	parameters	parameter	NOUN
bioscience-245	152	9	and	and	CCONJ
bioscience-245	152	10	increased	increase	VERB
bioscience-245	152	11	serotonin	serotonin	NOUN
bioscience-245	152	12	levels	level	NOUN
bioscience-245	152	13	in	in	ADP
bioscience-245	152	14	key	key	ADJ
bioscience-245	152	15	brain	brain	NOUN
bioscience-245	152	16	regions	region	NOUN
bioscience-245	152	17	affected	affect	VERB
bioscience-245	152	18	by	by	ADP
bioscience-245	152	19	depression	depression	NOUN
bioscience-245	152	20	.	.	PUNCT
bioscience-245	153	1	it	it	PRON
bioscience-245	153	2	also	also	ADV
bioscience-245	153	3	demonstrated	demonstrate	VERB
bioscience-245	153	4	potent	potent	ADJ
bioscience-245	153	5	antioxidant	antioxidant	ADJ
bioscience-245	153	6	effects	effect	NOUN
bioscience-245	153	7	,	,	PUNCT
bioscience-245	153	8	as	as	SCONJ
bioscience-245	153	9	evidenced	evidence	VERB
bioscience-245	153	10	by	by	ADP
bioscience-245	153	11	reduced	reduced	ADJ
bioscience-245	153	12	levels	level	NOUN
bioscience-245	153	13	of	of	ADP
bioscience-245	153	14	oxidative	oxidative	ADJ
bioscience-245	153	15	stress	stress	NOUN
bioscience-245	153	16	markers	marker	NOUN
bioscience-245	153	17	(	(	PUNCT
bioscience-245	153	18	no	no	INTJ
bioscience-245	153	19	,	,	PUNCT
bioscience-245	153	20	mda	mda	PROPN
bioscience-245	153	21	)	)	PUNCT
bioscience-245	153	22	and	and	CCONJ
bioscience-245	153	23	restored	restore	VERB
bioscience-245	153	24	activities	activity	NOUN
bioscience-245	153	25	of	of	ADP
bioscience-245	153	26	crucial	crucial	ADJ
bioscience-245	153	27	antioxidant	antioxidant	ADJ
bioscience-245	153	28	enzymes	enzyme	NOUN
bioscience-245	153	29	(	(	PUNCT
bioscience-245	153	30	sod	sod	NOUN
bioscience-245	153	31	and	and	CCONJ
bioscience-245	153	32	catalase	catalase	NOUN
bioscience-245	153	33	)	)	PUNCT
bioscience-245	153	34	.	.	PUNCT
bioscience-245	154	1	kinetic	kinetic	ADJ
bioscience-245	154	2	analyses	analysis	NOUN
bioscience-245	154	3	revealed	reveal	VERB
bioscience-245	154	4	that	that	SCONJ
bioscience-245	154	5	l	l	NOUN
bioscience-245	154	6	-	-	NOUN
bioscience-245	154	7	arginine	arginine	NOUN
bioscience-245	154	8	enhances	enhance	VERB
bioscience-245	154	9	enzyme	enzyme	NOUN
bioscience-245	154	10	activity	activity	NOUN
bioscience-245	154	11	primarily	primarily	ADV
bioscience-245	154	12	by	by	ADP
bioscience-245	154	13	increasing	increase	VERB
bioscience-245	154	14	enzyme	enzyme	NOUN
bioscience-245	154	15	synthesis	synthesis	NOUN
bioscience-245	154	16	,	,	PUNCT
bioscience-245	154	17	contrasting	contrast	VERB
bioscience-245	154	18	with	with	ADP
bioscience-245	154	19	the	the	DET
bioscience-245	154	20	dual	dual	ADJ
bioscience-245	154	21	structural	structural	ADJ
bioscience-245	154	22	and	and	CCONJ
bioscience-245	154	23	quantitative	quantitative	ADJ
bioscience-245	154	24	effects	effect	NOUN
bioscience-245	154	25	observed	observe	VERB
bioscience-245	154	26	with	with	ADP
bioscience-245	154	27	fluoxetine	fluoxetine	NOUN
bioscience-245	154	28	.	.	PUNCT
bioscience-245	155	1	collectively	collectively	ADV
bioscience-245	155	2	,	,	PUNCT
bioscience-245	155	3	these	these	DET
bioscience-245	155	4	findings	finding	NOUN
bioscience-245	155	5	suggest	suggest	VERB
bioscience-245	155	6	that	that	SCONJ
bioscience-245	155	7	l	l	NOUN
bioscience-245	155	8	-	-	NOUN
bioscience-245	155	9	arginine	arginine	NOUN
bioscience-245	155	10	exerts	exert	VERB
bioscience-245	155	11	its	its	PRON
bioscience-245	155	12	antidepressant	antidepressant	ADJ
bioscience-245	155	13	-	-	PUNCT
bioscience-245	155	14	like	like	ADJ
bioscience-245	155	15	effects	effect	NOUN
bioscience-245	155	16	through	through	ADP
bioscience-245	155	17	a	a	DET
bioscience-245	155	18	dual	dual	ADJ
bioscience-245	155	19	mechanism	mechanism	NOUN
bioscience-245	155	20	involving	involve	VERB
bioscience-245	155	21	both	both	CCONJ
bioscience-245	155	22	serotonin	serotonin	NOUN
bioscience-245	155	23	-	-	PUNCT
bioscience-245	155	24	mediated	mediate	VERB
bioscience-245	155	25	neurotransmission	neurotransmission	NOUN
bioscience-245	155	26	and	and	CCONJ
bioscience-245	155	27	improved	improve	VERB
bioscience-245	155	28	antioxidant	antioxidant	ADJ
bioscience-245	155	29	defense	defense	NOUN
bioscience-245	155	30	.	.	PUNCT
bioscience-245	156	1	given	give	VERB
bioscience-245	156	2	its	its	PRON
bioscience-245	156	3	natural	natural	ADJ
bioscience-245	156	4	origin	origin	NOUN
bioscience-245	156	5	and	and	CCONJ
bioscience-245	156	6	multifaceted	multifaceted	ADJ
bioscience-245	156	7	biological	biological	ADJ
bioscience-245	156	8	effects	effect	NOUN
bioscience-245	156	9	,	,	PUNCT
bioscience-245	156	10	l	l	NOUN
bioscience-245	156	11	-	-	NOUN
bioscience-245	156	12	arginine	arginine	NOUN
bioscience-245	156	13	may	may	AUX
bioscience-245	156	14	serve	serve	VERB
bioscience-245	156	15	as	as	ADP
bioscience-245	156	16	a	a	DET
bioscience-245	156	17	promising	promising	ADJ
bioscience-245	156	18	adjunct	adjunct	ADJ
bioscience-245	156	19	or	or	CCONJ
bioscience-245	156	20	alternative	alternative	ADJ
bioscience-245	156	21	to	to	ADP
bioscience-245	156	22	conventional	conventional	ADJ
bioscience-245	156	23	antidepressant	antidepressant	ADJ
bioscience-245	156	24	therapy	therapy	NOUN
bioscience-245	156	25	.	.	PUNCT
bioscience-245	157	1	further	further	ADJ
bioscience-245	157	2	research	research	NOUN
bioscience-245	157	3	is	be	AUX
bioscience-245	157	4	warranted	warrant	VERB
bioscience-245	157	5	to	to	PART
bioscience-245	157	6	elucidate	elucidate	VERB
bioscience-245	157	7	its	its	PRON
bioscience-245	157	8	precise	precise	ADJ
bioscience-245	157	9	molecular	molecular	ADJ
bioscience-245	157	10	mechanisms	mechanism	NOUN
bioscience-245	157	11	and	and	CCONJ
bioscience-245	157	12	evaluate	evaluate	VERB
bioscience-245	157	13	its	its	PRON
bioscience-245	157	14	clinical	clinical	ADJ
bioscience-245	157	15	potential	potential	NOUN
bioscience-245	157	16	.	.	PUNCT
bioscience-245	158	1	acknowledgements	acknowledgement	NOUN
bioscience-245	158	2	the	the	DET
bioscience-245	158	3	designated	designate	VERB
bioscience-245	158	4	project	project	NOUN
bioscience-245	158	5	is	be	AUX
bioscience-245	158	6	done	do	VERB
bioscience-245	158	7	with	with	ADP
bioscience-245	158	8	the	the	DET
bioscience-245	158	9	financial	financial	ADJ
bioscience-245	158	10	support	support	NOUN
bioscience-245	158	11	of	of	ADP
bioscience-245	158	12	the	the	DET
bioscience-245	158	13	shota	shota	ADJ
bioscience-245	158	14	rustaveli	rustaveli	ADJ
bioscience-245	158	15	georgian	georgian	PROPN
bioscience-245	158	16	national	national	PROPN
bioscience-245	158	17	science	science	PROPN
bioscience-245	158	18	foundation	foundation	PROPN
bioscience-245	158	19	(	(	PUNCT
bioscience-245	158	20	grant	grant	VERB
bioscience-245	158	21	#	#	SYM
bioscience-245	158	22	fr-23	fr-23	NOUN
bioscience-245	158	23	-	-	PUNCT
bioscience-245	158	24	7525	7525	NUM
bioscience-245	158	25	)	)	PUNCT
bioscience-245	158	26	.	.	PUNCT
bioscience-245	159	1	any	any	DET
bioscience-245	159	2	idea	idea	NOUN
bioscience-245	159	3	contained	contain	VERB
bioscience-245	159	4	in	in	ADP
bioscience-245	159	5	this	this	DET
bioscience-245	159	6	publication	publication	NOUN
bioscience-245	159	7	is	be	AUX
bioscience-245	159	8	the	the	DET
bioscience-245	159	9	authors	author	NOUN
bioscience-245	159	10	’	’	PART
bioscience-245	159	11	property	property	NOUN
bioscience-245	159	12	and	and	CCONJ
bioscience-245	159	13	may	may	AUX
bioscience-245	159	14	not	not	PART
bioscience-245	159	15	represent	represent	VERB
bioscience-245	159	16	the	the	DET
bioscience-245	159	17	opinion	opinion	NOUN
bioscience-245	159	18	of	of	ADP
bioscience-245	159	19	the	the	DET
bioscience-245	159	20	foundation	foundation	NOUN
bioscience-245	159	21	.	.	PUNCT
bioscience-245	160	1	reference	reference	NOUN
bioscience-245	160	2	1	1	NUM
bioscience-245	160	3	.	.	PUNCT
bioscience-245	161	1	yang	yang	PROPN
bioscience-245	161	2	l	l	PROPN
bioscience-245	161	3	,	,	PUNCT
bioscience-245	161	4	zhao	zhao	PROPN
bioscience-245	161	5	y	y	PROPN
bioscience-245	161	6	,	,	PUNCT
bioscience-245	161	7	wang	wang	PROPN
bioscience-245	161	8	y	y	PROPN
bioscience-245	161	9	,	,	PUNCT
bioscience-245	161	10	liu	liu	PROPN
bioscience-245	161	11	l	l	PROPN
bioscience-245	161	12	,	,	PUNCT
bioscience-245	161	13	zhang	zhang	PROPN
bioscience-245	161	14	x	x	PROPN
bioscience-245	161	15	,	,	PUNCT
bioscience-245	161	16	li	li	PROPN
bioscience-245	161	17	b	b	PROPN
bioscience-245	161	18	,	,	PUNCT
bioscience-245	161	19	et	et	PROPN
bioscience-245	161	20	al	al	PROPN
bioscience-245	161	21	.	.	PUNCT
bioscience-245	162	1	the	the	DET
bioscience-245	162	2	effects	effect	NOUN
bioscience-245	162	3	of	of	ADP
bioscience-245	162	4	psychological	psychological	ADJ
bioscience-245	162	5	stress	stress	NOUN
bioscience-245	162	6	on	on	ADP
bioscience-245	162	7	depression	depression	NOUN
bioscience-245	162	8	.	.	PUNCT
bioscience-245	163	1	current	current	ADJ
bioscience-245	163	2	neuropharmacology	neuropharmacology	NOUN
bioscience-245	163	3	.	.	PUNCT
bioscience-245	164	1	2015;13:494	2015;13:494	X
bioscience-245	164	2	.	.	NOUN
bioscience-245	164	3	2	2	NUM
bioscience-245	164	4	.	.	X
bioscience-245	164	5	patel	patel	PROPN
bioscience-245	164	6	sd	sd	PROPN
bioscience-245	164	7	,	,	PUNCT
bioscience-245	164	8	cameron	cameron	PROPN
bioscience-245	164	9	lp	lp	PROPN
bioscience-245	164	10	,	,	PUNCT
bioscience-245	164	11	olson	olson	PROPN
bioscience-245	164	12	de	de	PROPN
bioscience-245	164	13	.	.	PROPN
bioscience-245	164	14	sex	sex	NOUN
bioscience-245	164	15	-	-	PUNCT
bioscience-245	164	16	specific	specific	ADJ
bioscience-245	164	17	social	social	ADJ
bioscience-245	164	18	effects	effect	NOUN
bioscience-245	164	19	on	on	ADP
bioscience-245	164	20	depression	depression	NOUN
bioscience-245	164	21	-	-	PUNCT
bioscience-245	164	22	related	relate	VERB
bioscience-245	164	23	behavioral	behavioral	ADJ
bioscience-245	164	24	phenotypes	phenotype	NOUN
bioscience-245	164	25	in	in	ADP
bioscience-245	164	26	mice	mouse	NOUN
bioscience-245	164	27	.	.	PUNCT
bioscience-245	165	1	life	life	NOUN
bioscience-245	165	2	.	.	PUNCT
bioscience-245	166	1	2021;11:1327	2021;11:1327	NUM
bioscience-245	166	2	.	.	PUNCT
bioscience-245	167	1	3	3	X
bioscience-245	167	2	.	.	X
bioscience-245	167	3	james	james	PROPN
bioscience-245	167	4	sl	sl	PROPN
bioscience-245	167	5	,	,	PUNCT
bioscience-245	167	6	abate	abate	VERB
bioscience-245	167	7	d	d	NOUN
bioscience-245	167	8	,	,	PUNCT
bioscience-245	167	9	abate	abate	VERB
bioscience-245	167	10	kh	kh	PROPN
bioscience-245	167	11	,	,	PUNCT
bioscience-245	167	12	abay	abay	PROPN
bioscience-245	167	13	sm	sm	PROPN
bioscience-245	167	14	,	,	PUNCT
bioscience-245	167	15	abbafati	abbafati	PROPN
bioscience-245	167	16	c	c	PROPN
bioscience-245	167	17	,	,	PUNCT
bioscience-245	167	18	abbasi	abbasi	PROPN
bioscience-245	167	19	n	n	CCONJ
bioscience-245	167	20	,	,	PUNCT
bioscience-245	167	21	et	et	PROPN
bioscience-245	167	22	al	al	PROPN
bioscience-245	167	23	.	.	PUNCT
bioscience-245	168	1	global	global	ADJ
bioscience-245	168	2	,	,	PUNCT
bioscience-245	168	3	regional	regional	ADJ
bioscience-245	168	4	,	,	PUNCT
bioscience-245	168	5	and	and	CCONJ
bioscience-245	168	6	national	national	ADJ
bioscience-245	168	7	incidence	incidence	NOUN
bioscience-245	168	8	,	,	PUNCT
bioscience-245	168	9	prevalence	prevalence	NOUN
bioscience-245	168	10	,	,	PUNCT
bioscience-245	168	11	and	and	CCONJ
bioscience-245	168	12	years	year	NOUN
bioscience-245	168	13	lived	live	VERB
bioscience-245	168	14	systematic	systematic	ADJ
bioscience-245	168	15	analysis	analysis	NOUN
bioscience-245	168	16	for	for	ADP
bioscience-245	168	17	the	the	DET
bioscience-245	168	18	global	global	ADJ
bioscience-245	168	19	burden	burden	NOUN
bioscience-245	168	20	of	of	ADP
bioscience-245	168	21	disease	disease	NOUN
bioscience-245	168	22	study	study	NOUN
bioscience-245	168	23	.	.	PUNCT
bioscience-245	169	1	the	the	DET
bioscience-245	169	2	lancet	lancet	NOUN
bioscience-245	169	3	.	.	PUNCT
bioscience-245	170	1	2018;392:1789	2018;392:1789	NUM
bioscience-245	170	2	.	.	X
bioscience-245	170	3	4	4	NUM
bioscience-245	170	4	.	.	NOUN
bioscience-245	170	5	sterner	stern	ADJ
bioscience-245	170	6	ey	ey	NOUN
bioscience-245	170	7	,	,	PUNCT
bioscience-245	170	8	kalynchuk	kalynchuk	PROPN
bioscience-245	170	9	le	le	X
bioscience-245	170	10	.	.	PUNCT
bioscience-245	170	11	behavioral	behavioral	ADJ
bioscience-245	170	12	and	and	CCONJ
bioscience-245	170	13	neurobiological	neurobiological	ADJ
bioscience-245	170	14	consequences	consequence	NOUN
bioscience-245	170	15	of	of	ADP
bioscience-245	170	16	prolonged	prolonged	ADJ
bioscience-245	170	17	glucocorticoid	glucocorticoid	ADJ
bioscience-245	170	18	exposure	exposure	NOUN
bioscience-245	170	19	in	in	ADP
bioscience-245	170	20	rats	rat	NOUN
bioscience-245	170	21	:	:	PUNCT
bioscience-245	170	22	relevance	relevance	NOUN
bioscience-245	170	23	to	to	ADP
bioscience-245	170	24	depression	depression	NOUN
bioscience-245	170	25	.	.	PUNCT
bioscience-245	171	1	progress	progress	NOUN
bioscience-245	171	2	in	in	ADP
bioscience-245	171	3	neuropsychopharmacology	neuropsychopharmacology	PROPN
bioscience-245	171	4	biological	biological	ADJ
bioscience-245	171	5	psychiatry	psychiatry	NOUN
bioscience-245	171	6	.	.	PUNCT
bioscience-245	172	1	2010;34:777	2010;34:777	NUM
bioscience-245	172	2	.	.	NOUN
bioscience-245	172	3	5	5	NUM
bioscience-245	172	4	.	.	X
bioscience-245	172	5	zhao	zhao	PROPN
bioscience-245	172	6	y	y	PROPN
bioscience-245	172	7	,	,	PUNCT
bioscience-245	172	8	ma	ma	PROPN
bioscience-245	172	9	r	r	PROPN
bioscience-245	172	10	,	,	PUNCT
bioscience-245	172	11	shen	shen	PROPN
bioscience-245	172	12	j	j	PROPN
bioscience-245	172	13	,	,	PUNCT
bioscience-245	172	14	su	su	PROPN
bioscience-245	172	15	h	h	PROPN
bioscience-245	172	16	,	,	PUNCT
bioscience-245	172	17	xing	xing	PROPN
bioscience-245	172	18	d	d	PROPN
bioscience-245	172	19	,	,	PUNCT
bioscience-245	172	20	du	du	PROPN
bioscience-245	172	21	l.	l.	PROPN
bioscience-245	172	22	a	a	DET
bioscience-245	172	23	mouse	mouse	NOUN
bioscience-245	172	24	model	model	NOUN
bioscience-245	172	25	of	of	ADP
bioscience-245	172	26	depression	depression	NOUN
bioscience-245	172	27	induced	induce	VERB
bioscience-245	172	28	by	by	ADP
bioscience-245	172	29	repeated	repeat	VERB
bioscience-245	172	30	corticosterone	corticosterone	NOUN
bioscience-245	172	31	injections	injection	NOUN
bioscience-245	172	32	.	.	PUNCT
bioscience-245	173	1	european	european	ADJ
bioscience-245	173	2	journal	journal	PROPN
bioscience-245	173	3	of	of	ADP
bioscience-245	173	4	pharmacology	pharmacology	NOUN
bioscience-245	173	5	.	.	PUNCT
bioscience-245	174	1	2008;581:113	2008;581:113	X
bioscience-245	174	2	.	.	X
bioscience-245	175	1	6	6	NUM
bioscience-245	175	2	.	.	X
bioscience-245	175	3	albert	albert	PROPN
bioscience-245	175	4	pr	pr	PROPN
bioscience-245	175	5	lc	lc	PROPN
bioscience-245	175	6	vahid	vahid	PROPN
bioscience-245	175	7	-	-	PUNCT
bioscience-245	175	8	ansari	ansari	PROPN
bioscience-245	175	9	f.	f.	PROPN
bioscience-245	175	10	serotonin	serotonin	NOUN
bioscience-245	175	11	-	-	PUNCT
bioscience-245	175	12	prefrontal	prefrontal	ADJ
bioscience-245	175	13	cortical	cortical	ADJ
bioscience-245	175	14	circuitry	circuitry	NOUN
bioscience-245	175	15	in	in	ADP
bioscience-245	175	16	anxiety	anxiety	NOUN
bioscience-245	175	17	and	and	CCONJ
bioscience-245	175	18	depression	depression	NOUN
bioscience-245	175	19	phenotypes	phenotype	NOUN
bioscience-245	175	20	:	:	PUNCT
bioscience-245	175	21	pivotal	pivotal	ADJ
bioscience-245	175	22	role	role	NOUN
bioscience-245	175	23	of	of	ADP
bioscience-245	175	24	preand	preand	VERB
bioscience-245	175	25	post	post	ADJ
bioscience-245	175	26	-	-	ADJ
bioscience-245	175	27	synaptic	synaptic	ADJ
bioscience-245	175	28	5	5	NUM
bioscience-245	175	29	-	-	NUM
bioscience-245	175	30	ht1a	ht1a	NUM
bioscience-245	175	31	receptor	receptor	NOUN
bioscience-245	175	32	expression	expression	NOUN
bioscience-245	175	33	.	.	PUNCT
bioscience-245	176	1	front	front	ADJ
bioscience-245	176	2	behav	behav	PROPN
bioscience-245	176	3	neurosci	neurosci	PROPN
bioscience-245	176	4	.	.	PUNCT
bioscience-245	177	1	2014	2014	NUM
bioscience-245	177	2	.	.	PUNCT
bioscience-245	178	1	7	7	X
bioscience-245	178	2	.	.	X
bioscience-245	178	3	liu	liu	PROPN
bioscience-245	178	4	y	y	PROPN
bioscience-245	178	5	gw	gw	PROPN
bioscience-245	178	6	.	.	PUNCT
bioscience-245	179	1	emotional	emotional	ADJ
bioscience-245	179	2	roles	role	NOUN
bioscience-245	179	3	of	of	ADP
bioscience-245	179	4	mono	mono	NOUN
bioscience-245	179	5	-	-	PUNCT
bioscience-245	179	6	aminergic	aminergic	ADJ
bioscience-245	179	7	neurotransmitters	neurotransmitter	NOUN
bioscience-245	179	8	in	in	ADP
bioscience-245	179	9	major	major	ADJ
bioscience-245	179	10	depressive	depressive	ADJ
bioscience-245	179	11	disorder	disorder	NOUN
bioscience-245	179	12	and	and	CCONJ
bioscience-245	179	13	anxiety	anxiety	NOUN
bioscience-245	179	14	disorders	disorder	NOUN
bioscience-245	179	15	.	.	PUNCT
bioscience-245	180	1	front	front	ADJ
bioscience-245	180	2	psychol	psychol	NOUN
bioscience-245	180	3	.	.	PUNCT
bioscience-245	181	1	2018;9	2018;9	NUM
bioscience-245	181	2	.	.	PUNCT
bioscience-245	182	1	8	8	NUM
bioscience-245	182	2	.	.	X
bioscience-245	182	3	liwinski	liwinski	PROPN
bioscience-245	182	4	t	t	PROPN
bioscience-245	182	5	base	base	PROPN
bioscience-245	182	6	lang	lang	PROPN
bioscience-245	182	7	ue	ue	PROPN
bioscience-245	182	8	.	.	PUNCT
bioscience-245	183	1	exploring	explore	VERB
bioscience-245	183	2	the	the	DET
bioscience-245	183	3	therapeutic	therapeutic	ADJ
bioscience-245	183	4	potential	potential	NOUN
bioscience-245	183	5	of	of	ADP
bioscience-245	183	6	gamma	gamma	NOUN
bioscience-245	183	7	-	-	PUNCT
bioscience-245	183	8	aminobutyric	aminobutyric	ADJ
bioscience-245	183	9	acid	acid	NOUN
bioscience-245	183	10	in	in	ADP
bioscience-245	183	11	stress	stress	NOUN
bioscience-245	183	12	and	and	CCONJ
bioscience-245	183	13	depressive	depressive	ADJ
bioscience-245	183	14	disorders	disorder	NOUN
bioscience-245	183	15	through	through	ADP
bioscience-245	183	16	the	the	DET
bioscience-245	183	17	gutbrain	gutbrain	NOUN
bioscience-245	183	18	axis	axis	NOUN
bioscience-245	183	19	.	.	PUNCT
bioscience-245	184	1	biomedicines	biomedicine	NOUN
bioscience-245	184	2	.	.	PUNCT
bioscience-245	185	1	2023;11:3128	2023;11:3128	NUM
bioscience-245	185	2	.	.	NOUN
bioscience-245	186	1	9	9	NUM
bioscience-245	186	2	.	.	X
bioscience-245	186	3	bayes	bayes	PROPN
bioscience-245	186	4	aj	aj	PROPN
bioscience-245	186	5	pg	pg	PROPN
bioscience-245	186	6	.	.	PUNCT
bioscience-245	187	1	comparison	comparison	NOUN
bioscience-245	187	2	of	of	ADP
bioscience-245	187	3	guidelines	guideline	NOUN
bioscience-245	187	4	for	for	ADP
bioscience-245	187	5	the	the	DET
bioscience-245	187	6	treatment	treatment	NOUN
bioscience-245	187	7	of	of	ADP
bioscience-245	187	8	unipolar	unipolar	ADJ
bioscience-245	187	9	depression	depression	NOUN
bioscience-245	187	10	:	:	PUNCT
bioscience-245	187	11	a	a	DET
bioscience-245	187	12	focus	focus	NOUN
bioscience-245	187	13	on	on	ADP
bioscience-245	187	14	pharmacotherapy	pharmacotherapy	NOUN
bioscience-245	187	15	and	and	CCONJ
bioscience-245	187	16	neurostimulation	neurostimulation	NOUN
bioscience-245	187	17	.	.	PUNCT
bioscience-245	188	1	acta	acta	PROPN
bioscience-245	188	2	psychiatr	psychiatr	PROPN
bioscience-245	188	3	scand	scand	PROPN
bioscience-245	188	4	.	.	PUNCT
bioscience-245	189	1	2018;137:459	2018;137:459	X
bioscience-245	189	2	.	.	NOUN
bioscience-245	189	3	10	10	NUM
bioscience-245	189	4	.	.	PUNCT
bioscience-245	190	1	shah	shah	PROPN
bioscience-245	190	2	khoodoruth	khoodoruth	PROPN
bioscience-245	190	3	mas	mas	PROPN
bioscience-245	190	4	pbknackgos	pbknackgos	PROPN
bioscience-245	190	5	estudilloguerra	estudilloguerra	PROPN
bioscience-245	190	6	ma	ma	PROPN
bioscience-245	190	7	.	.	PROPN
bioscience-245	190	8	glutamatergic	glutamatergic	ADJ
bioscience-245	190	9	system	system	NOUN
bioscience-245	190	10	in	in	ADP
bioscience-245	190	11	depression	depression	NOUN
bioscience-245	190	12	and	and	CCONJ
bioscience-245	190	13	its	its	PRON
bioscience-245	190	14	role	role	NOUN
bioscience-245	190	15	in	in	ADP
bioscience-245	190	16	neuromodulatory	neuromodulatory	ADJ
bioscience-245	190	17	techniques	technique	NOUN
bioscience-245	190	18	optimization	optimization	NOUN
bioscience-245	190	19	.	.	PUNCT
bioscience-245	191	1	front	front	ADJ
bioscience-245	191	2	psychiatry	psychiatry	NOUN
bioscience-245	191	3	.	.	PUNCT
bioscience-245	192	1	2022;14	2022;14	NUM
bioscience-245	192	2	.	.	PUNCT
bioscience-245	193	1	11	11	NUM
bioscience-245	193	2	.	.	PUNCT
bioscience-245	194	1	galts	galt	NOUN
bioscience-245	194	2	cpc	cpc	PROPN
bioscience-245	194	3	,	,	PUNCT
bioscience-245	194	4	bettio	bettio	PROPN
bioscience-245	194	5	eb	eb	PROPN
bioscience-245	194	6	,	,	PUNCT
bioscience-245	194	7	jewett	jewett	PROPN
bioscience-245	194	8	dc	dc	PROPN
bioscience-245	194	9	,	,	PUNCT
bioscience-245	194	10	yang	yang	PROPN
bioscience-245	194	11	cc	cc	PROPN
bioscience-245	194	12	,	,	PUNCT
bioscience-245	194	13	brocardo	brocardo	PROPN
bioscience-245	194	14	ps	ps	PROPN
bioscience-245	194	15	,	,	PUNCT
bioscience-245	194	16	rodrigues	rodrigues	PROPN
bioscience-245	194	17	als	als	PROPN
bioscience-245	194	18	.	.	PUNCT
bioscience-245	195	1	deppression	deppression	NOUN
bioscience-245	195	2	in	in	ADP
bioscience-245	195	3	neurodegenerative	neurodegenerative	ADJ
bioscience-245	195	4	diseases	disease	NOUN
bioscience-245	195	5	:	:	PUNCT
bioscience-245	195	6	common	common	ADJ
bioscience-245	195	7	mechanisms	mechanism	NOUN
bioscience-245	195	8	and	and	CCONJ
bioscience-245	195	9	current	current	ADJ
bioscience-245	195	10	treatment	treatment	NOUN
bioscience-245	195	11	options	option	NOUN
bioscience-245	195	12	.	.	PUNCT
bioscience-245	196	1	neuroscience	neuroscience	NOUN
bioscience-245	196	2	biobehavioral	biobehavioral	ADJ
bioscience-245	196	3	reviews	review	NOUN
bioscience-245	196	4	.	.	PUNCT
bioscience-245	197	1	2019;102:56	2019;102:56	NUM
bioscience-245	197	2	.	.	PUNCT
bioscience-245	198	1	12	12	NUM
bioscience-245	198	2	.	.	PUNCT
bioscience-245	199	1	duman	duman	PROPN
bioscience-245	199	2	rs	rs	PROPN
bioscience-245	199	3	,	,	PUNCT
bioscience-245	199	4	aghajanian	aghajanian	PROPN
bioscience-245	199	5	gk	gk	PROPN
bioscience-245	199	6	,	,	PUNCT
bioscience-245	199	7	sanacora	sanacora	NOUN
bioscience-245	199	8	g	g	PROPN
bioscience-245	199	9	,	,	PUNCT
bioscience-245	199	10	krystal	krystal	PROPN
bioscience-245	199	11	jh	jh	PROPN
bioscience-245	199	12	.	.	PUNCT
bioscience-245	200	1	synaptic	synaptic	ADJ
bioscience-245	200	2	plasticity	plasticity	NOUN
bioscience-245	200	3	and	and	CCONJ
bioscience-245	200	4	depression	depression	NOUN
bioscience-245	200	5	:	:	PUNCT
bioscience-245	200	6	new	new	ADJ
bioscience-245	200	7	insights	insight	NOUN
bioscience-245	200	8	from	from	ADP
bioscience-245	200	9	stress	stress	NOUN
bioscience-245	200	10	and	and	CCONJ
bioscience-245	200	11	rapid	rapid	ADJ
bioscience-245	200	12	-	-	PUNCT
bioscience-245	200	13	acting	act	VERB
bioscience-245	200	14	antidepressants	antidepressant	NOUN
bioscience-245	200	15	.	.	PUNCT
bioscience-245	201	1	nature	nature	NOUN
bioscience-245	201	2	medicine	medicine	NOUN
bioscience-245	201	3	.	.	PUNCT
bioscience-245	202	1	2016;22:238	2016;22:238	NUM
bioscience-245	202	2	.	.	NOUN
bioscience-245	202	3	13	13	NUM
bioscience-245	202	4	.	.	PUNCT
bioscience-245	203	1	li	li	PROPN
bioscience-245	203	2	x	x	PROPN
bioscience-245	203	3	,	,	PUNCT
bioscience-245	203	4	witkin	witkin	PROPN
bioscience-245	203	5	jm	jm	PROPN
bioscience-245	203	6	,	,	PUNCT
bioscience-245	203	7	need	need	VERB
bioscience-245	203	8	ab	ab	PROPN
bioscience-245	203	9	,	,	PUNCT
bioscience-245	203	10	skolnick	skolnick	PROPN
bioscience-245	203	11	p.	p.	PROPN
bioscience-245	203	12	enhancement	enhancement	NOUN
bioscience-245	203	13	of	of	ADP
bioscience-245	203	14	antidepressant	antidepressant	ADJ
bioscience-245	203	15	potency	potency	NOUN
bioscience-245	203	16	by	by	ADP
bioscience-245	203	17	a	a	DET
bioscience-245	203	18	potentiator	potentiator	NOUN
bioscience-245	203	19	of	of	ADP
bioscience-245	203	20	ampa	ampa	NOUN
bioscience-245	203	21	receptors	receptor	NOUN
bioscience-245	203	22	.	.	PUNCT
bioscience-245	204	1	cellular	cellular	ADJ
bioscience-245	204	2	and	and	CCONJ
bioscience-245	204	3	molecular	molecular	ADJ
bioscience-245	204	4	neurobiology	neurobiology	NOUN
bioscience-245	204	5	.	.	PUNCT
bioscience-245	205	1	2003;23:419	2003;23:419	X
bioscience-245	205	2	.	.	PUNCT
bioscience-245	206	1	14	14	NUM
bioscience-245	206	2	.	.	PUNCT
bioscience-245	206	3	tong	tong	PROPN
bioscience-245	206	4	bc	bc	PROPN
bioscience-245	206	5	,	,	PUNCT
bioscience-245	206	6	barbul	barbul	VERB
bioscience-245	206	7	a.	a.	NOUN
bioscience-245	206	8	cellular	cellular	ADJ
bioscience-245	206	9	and	and	CCONJ
bioscience-245	206	10	physiological	physiological	ADJ
bioscience-245	206	11	effects	effect	NOUN
bioscience-245	206	12	of	of	ADP
bioscience-245	206	13	arginine	arginine	NOUN
bioscience-245	206	14	.	.	PUNCT
bioscience-245	207	1	mini	mini	ADJ
bioscience-245	207	2	reviews	review	NOUN
bioscience-245	207	3	in	in	ADP
bioscience-245	207	4	medicinal	medicinal	ADJ
bioscience-245	207	5	chemistry	chemistry	NOUN
bioscience-245	207	6	.	.	PUNCT
bioscience-245	208	1	2004;4:823	2004;4:823	NUM
bioscience-245	208	2	.	.	NOUN
bioscience-245	208	3	15	15	NUM
bioscience-245	208	4	.	.	PUNCT
bioscience-245	209	1	cryan	cryan	PROPN
bioscience-245	209	2	jf	jf	PROPN
bioscience-245	209	3	,	,	PUNCT
bioscience-245	209	4	mombereau	mombereau	NOUN
bioscience-245	209	5	c	c	NOUN
bioscience-245	209	6	,	,	PUNCT
bioscience-245	209	7	vassout	vassout	ADP
bioscience-245	209	8	a.	a.	NOUN
bioscience-245	209	9	the	the	DET
bioscience-245	209	10	tail	tail	NOUN
bioscience-245	209	11	suspension	suspension	NOUN
bioscience-245	209	12	test	test	NOUN
bioscience-245	209	13	as	as	ADP
bioscience-245	209	14	a	a	DET
bioscience-245	209	15	model	model	NOUN
bioscience-245	209	16	for	for	ADP
bioscience-245	209	17	assessing	assess	VERB
bioscience-245	209	18	antidepressant	antidepressant	ADJ
bioscience-245	209	19	activity	activity	NOUN
bioscience-245	209	20	:	:	PUNCT
bioscience-245	209	21	review	review	NOUN
bioscience-245	209	22	of	of	ADP
bioscience-245	209	23	pharmacological	pharmacological	ADJ
bioscience-245	209	24	and	and	CCONJ
bioscience-245	209	25	genetic	genetic	ADJ
bioscience-245	209	26	studies	study	NOUN
bioscience-245	209	27	in	in	ADP
bioscience-245	209	28	mice	mouse	NOUN
bioscience-245	209	29	.	.	PUNCT
bioscience-245	210	1	neuroscience	neuroscience	NOUN
bioscience-245	210	2	biobehavioral	biobehavioral	ADJ
bioscience-245	210	3	reviews	review	NOUN
bioscience-245	210	4	.	.	PUNCT
bioscience-245	211	1	2005;29(4	2005;29(4	NUM
bioscience-245	211	2	-	-	SYM
bioscience-245	211	3	5):571	5):571	PROPN
bioscience-245	211	4	-	-	PUNCT
bioscience-245	211	5	625	625	NUM
bioscience-245	211	6	.	.	PUNCT
bioscience-245	212	1	16	16	NUM
bioscience-245	212	2	.	.	PUNCT
bioscience-245	213	1	förstermann	förstermann	PROPN
bioscience-245	213	2	u	u	PROPN
bioscience-245	213	3	,	,	PUNCT
bioscience-245	213	4	sessa	sessa	PROPN
bioscience-245	213	5	wc	wc	PROPN
bioscience-245	213	6	.	.	PROPN
bioscience-245	213	7	nitric	nitric	ADJ
bioscience-245	213	8	oxide	oxide	NOUN
bioscience-245	213	9	synthases	synthase	NOUN
bioscience-245	213	10	:	:	PUNCT
bioscience-245	213	11	regulation	regulation	NOUN
bioscience-245	213	12	and	and	CCONJ
bioscience-245	213	13	function	function	NOUN
bioscience-245	213	14	.	.	PUNCT
bioscience-245	214	1	european	european	ADJ
bioscience-245	214	2	heart	heart	PROPN
bioscience-245	214	3	journal	journal	PROPN
bioscience-245	214	4	.	.	PUNCT
bioscience-245	215	1	2012;33:829	2012;33:829	X
bioscience-245	215	2	.	.	PUNCT
bioscience-245	216	1	17	17	NUM
bioscience-245	216	2	.	.	PUNCT
bioscience-245	217	1	haj	haj	PROPN
bioscience-245	217	2	-	-	PROPN
bioscience-245	217	3	mirzaian	mirzaian	PROPN
bioscience-245	217	4	a	a	NOUN
bioscience-245	217	5	,	,	PUNCT
bioscience-245	217	6	amiri	amiri	PROPN
bioscience-245	217	7	s	s	PART
bioscience-245	217	8	,	,	PUNCT
bioscience-245	217	9	amini	amini	PROPN
bioscience-245	217	10	-	-	ADJ
bioscience-245	217	11	khoei	khoei	ADJ
bioscience-245	217	12	h	h	NOUN
bioscience-245	217	13	,	,	PUNCT
bioscience-245	217	14	haj	haj	PROPN
bioscience-245	217	15	-	-	ADJ
bioscience-245	217	16	mirzaian	mirzaian	PROPN
bioscience-245	217	17	a	a	NOUN
bioscience-245	217	18	,	,	PUNCT
bioscience-245	217	19	hashemiaghdam	hashemiaghdam	NOUN
bioscience-245	217	20	a	a	PRON
bioscience-245	217	21	,	,	PUNCT
bioscience-245	217	22	ramezanzadeh	ramezanzadeh	NOUN
bioscience-245	217	23	k	k	PROPN
bioscience-245	217	24	,	,	PUNCT
bioscience-245	217	25	et	et	PROPN
bioscience-245	217	26	al	al	PROPN
bioscience-245	217	27	.	.	PUNCT
bioscience-245	217	28	involvement	involvement	NOUN
bioscience-245	217	29	of	of	ADP
bioscience-245	217	30	no	no	DET
bioscience-245	217	31	/	/	SYM
bioscience-245	217	32	nmda	nmda	ADJ
bioscience-245	217	33	-	-	PUNCT
bioscience-245	217	34	r	r	NOUN
bioscience-245	217	35	pathway	pathway	NOUN
bioscience-245	217	36	in	in	ADP
bioscience-245	217	37	the	the	DET
bioscience-245	217	38	behavioral	behavioral	ADJ
bioscience-245	217	39	despair	despair	NOUN
bioscience-245	217	40	induced	induce	VERB
bioscience-245	217	41	by	by	ADP
bioscience-245	217	42	amphetamine	amphetamine	PROPN
bioscience-245	217	43	withdrawal	withdrawal	PROPN
bioscience-245	217	44	.	.	PUNCT
bioscience-245	218	1	brain	brain	NOUN
bioscience-245	218	2	research	research	NOUN
bioscience-245	218	3	bulletin	bulletin	NOUN
bioscience-245	218	4	.	.	PUNCT
bioscience-245	219	1	2018;139:81	2018;139:81	NUM
bioscience-245	219	2	.	.	PUNCT
bioscience-245	220	1	18	18	NUM
bioscience-245	220	2	.	.	X
bioscience-245	220	3	forbes	forbes	PROPN
bioscience-245	220	4	sc	sc	PROPN
bioscience-245	220	5	,	,	PUNCT
bioscience-245	220	6	harber	harber	PROPN
bioscience-245	220	7	v	v	PROPN
bioscience-245	220	8	,	,	PUNCT
bioscience-245	220	9	bell	bell	PROPN
bioscience-245	220	10	gj	gj	PROPN
bioscience-245	220	11	.	.	PUNCT
bioscience-245	221	1	oral	oral	ADJ
bioscience-245	221	2	l	l	NOUN
bioscience-245	221	3	-	-	NOUN
bioscience-245	221	4	arginine	arginine	NOUN
bioscience-245	221	5	before	before	ADP
bioscience-245	221	6	resistance	resistance	NOUN
bioscience-245	221	7	exercise	exercise	NOUN
bioscience-245	221	8	blunts	blunt	NOUN
bioscience-245	221	9	growth	growth	NOUN
bioscience-245	221	10	hormone	hormone	NOUN
bioscience-245	221	11	in	in	ADP
bioscience-245	221	12	strength	strength	NOUN
bioscience-245	221	13	trained	train	VERB
bioscience-245	221	14	males	male	NOUN
bioscience-245	221	15	.	.	PUNCT
bioscience-245	222	1	international	international	ADJ
bioscience-245	222	2	journal	journal	PROPN
bioscience-245	222	3	of	of	ADP
bioscience-245	222	4	sport	sport	PROPN
bioscience-245	222	5	nutrition	nutrition	NOUN
bioscience-245	222	6	and	and	CCONJ
bioscience-245	222	7	exercise	exercise	VERB
bioscience-245	222	8	metabolism	metabolism	NOUN
bioscience-245	222	9	.	.	PUNCT
bioscience-245	223	1	2014;24:236	2014;24:236	X
bioscience-245	223	2	.	.	PROPN
bioscience-245	223	3	highlights	highlight	NOUN
bioscience-245	223	4	in	in	ADP
bioscience-245	223	5	bioscience	bioscience	NOUN
bioscience-245	223	6	page	page	NOUN
bioscience-245	223	7	6	6	NUM
bioscience-245	223	8	of	of	ADP
bioscience-245	223	9	7	7	NUM
bioscience-245	223	10	june	june	PROPN
bioscience-245	223	11	2025|volume	2025|volume	NUM
bioscience-245	223	12	8	8	NUM
bioscience-245	223	13	http://bioscience.highlightsin.org/	http://bioscience.highlightsin.org/	NOUN
bioscience-245	223	14	mantashashvili	mantashashvili	NOUN
bioscience-245	223	15	t	t	PROPN
bioscience-245	223	16	et	et	PROPN
bioscience-245	223	17	al	al	PROPN
bioscience-245	223	18	.	.	PROPN
bioscience-245	223	19	,	,	PUNCT
bioscience-245	223	20	2025	2025	NUM
bioscience-245	223	21	l	l	NOUN
bioscience-245	223	22	-	-	NOUN
bioscience-245	223	23	arginine	arginine	NOUN
bioscience-245	223	24	as	as	ADP
bioscience-245	223	25	a	a	DET
bioscience-245	223	26	potential	potential	ADJ
bioscience-245	223	27	antidepressant	antidepressant	NOUN
bioscience-245	223	28	:	:	PUNCT
bioscience-245	223	29	effects	effect	NOUN
bioscience-245	223	30	on	on	ADP
bioscience-245	223	31	cognitive	cognitive	ADJ
bioscience-245	223	32	function	function	NOUN
bioscience-245	223	33	19	19	NUM
bioscience-245	223	34	.	.	PUNCT
bioscience-245	224	1	fujiwara	fujiwara	PROPN
bioscience-245	224	2	t	t	PROPN
bioscience-245	224	3	,	,	PUNCT
bioscience-245	224	4	kanazawa	kanazawa	PROPN
bioscience-245	224	5	s	s	PART
bioscience-245	224	6	,	,	PUNCT
bioscience-245	224	7	ichibori	ichibori	NOUN
bioscience-245	224	8	r	r	PROPN
bioscience-245	224	9	,	,	PUNCT
bioscience-245	224	10	tanigawa	tanigawa	PROPN
bioscience-245	224	11	t	t	PROPN
bioscience-245	224	12	,	,	PUNCT
bioscience-245	224	13	magome	magome	PROPN
bioscience-245	224	14	t	t	PROPN
bioscience-245	224	15	,	,	PUNCT
bioscience-245	224	16	shingaki	shingaki	PROPN
bioscience-245	224	17	k	k	NOUN
bioscience-245	224	18	,	,	PUNCT
bioscience-245	224	19	et	et	PROPN
bioscience-245	224	20	al	al	PROPN
bioscience-245	224	21	.	.	PUNCT
bioscience-245	225	1	l	l	NOUN
bioscience-245	225	2	-	-	PUNCT
bioscience-245	225	3	arginine	arginine	NOUN
bioscience-245	225	4	stimulates	stimulate	VERB
bioscience-245	225	5	fibroblast	fibroblast	ADJ
bioscience-245	225	6	proliferation	proliferation	NOUN
bioscience-245	225	7	through	through	ADP
bioscience-245	225	8	the	the	DET
bioscience-245	225	9	gprc6a	gprc6a	PROPN
bioscience-245	225	10	-	-	PUNCT
bioscience-245	225	11	erk1/2	erk1/2	PROPN
bioscience-245	225	12	and	and	CCONJ
bioscience-245	225	13	pi3k	pi3k	PROPN
bioscience-245	225	14	/	/	SYM
bioscience-245	225	15	akt	akt	PROPN
bioscience-245	225	16	pathway	pathway	NOUN
bioscience-245	225	17	.	.	PUNCT
bioscience-245	226	1	plos	plos	PROPN
bioscience-245	226	2	one	one	NUM
bioscience-245	226	3	.	.	PUNCT
bioscience-245	227	1	2014;9	2014;9	NUM
bioscience-245	227	2	:	:	PUNCT
bioscience-245	227	3	e92168	e92168	NOUN
bioscience-245	227	4	.	.	PROPN
bioscience-245	228	1	20	20	NUM
bioscience-245	228	2	.	.	PUNCT
bioscience-245	229	1	liang	liang	PROPN
bioscience-245	229	2	m	m	PROPN
bioscience-245	229	3	,	,	PUNCT
bioscience-245	229	4	wang	wang	PROPN
bioscience-245	229	5	z	z	PROPN
bioscience-245	229	6	,	,	PUNCT
bioscience-245	229	7	li	li	PROPN
bioscience-245	229	8	h	h	PROPN
bioscience-245	229	9	,	,	PUNCT
bioscience-245	229	10	cai	cai	PROPN
bioscience-245	229	11	l	l	PROPN
bioscience-245	229	12	,	,	PUNCT
bioscience-245	229	13	pan	pan	PROPN
bioscience-245	229	14	j	j	PROPN
bioscience-245	229	15	,	,	PUNCT
bioscience-245	229	16	he	he	PRON
bioscience-245	229	17	h	h	VERB
bioscience-245	229	18	,	,	PUNCT
bioscience-245	229	19	et	et	PROPN
bioscience-245	229	20	al	al	PROPN
bioscience-245	229	21	.	.	PUNCT
bioscience-245	230	1	l	l	NOUN
bioscience-245	230	2	-	-	NOUN
bioscience-245	230	3	arginine	arginine	NOUN
bioscience-245	230	4	induces	induce	VERB
bioscience-245	230	5	antioxidant	antioxidant	ADJ
bioscience-245	230	6	response	response	NOUN
bioscience-245	230	7	to	to	PART
bioscience-245	230	8	prevent	prevent	VERB
bioscience-245	230	9	oxidative	oxidative	ADJ
bioscience-245	230	10	stress	stress	NOUN
bioscience-245	230	11	via	via	ADP
bioscience-245	230	12	stimulation	stimulation	NOUN
bioscience-245	230	13	of	of	ADP
bioscience-245	230	14	glutathione	glutathione	NOUN
bioscience-245	230	15	synthesis	synthesis	NOUN
bioscience-245	230	16	and	and	CCONJ
bioscience-245	230	17	activation	activation	NOUN
bioscience-245	230	18	of	of	ADP
bioscience-245	230	19	nrf2	nrf2	NOUN
bioscience-245	230	20	pathway	pathway	NOUN
bioscience-245	230	21	.	.	PUNCT
bioscience-245	231	1	food	food	NOUN
bioscience-245	231	2	and	and	CCONJ
bioscience-245	231	3	chemical	chemical	NOUN
bioscience-245	231	4	toxicology	toxicology	NOUN
bioscience-245	231	5	.	.	PUNCT
bioscience-245	232	1	2018;115:315	2018;115:315	NUM
bioscience-245	232	2	-	-	SYM
bioscience-245	232	3	28	28	NUM
bioscience-245	232	4	.	.	PUNCT
bioscience-245	233	1	21	21	NUM
bioscience-245	233	2	.	.	PUNCT
bioscience-245	233	3	burjanadze	burjanadze	PROPN
bioscience-245	233	4	g	g	PROPN
bioscience-245	233	5	,	,	PUNCT
bioscience-245	233	6	shengeli	shengeli	PROPN
bioscience-245	233	7	m	m	PROPN
bioscience-245	233	8	,	,	PUNCT
bioscience-245	233	9	tsverava	tsverava	NOUN
bioscience-245	233	10	l	l	NOUN
bioscience-245	233	11	,	,	PUNCT
bioscience-245	233	12	mikadze	mikadze	PROPN
bioscience-245	233	13	m	m	PROPN
bioscience-245	233	14	,	,	PUNCT
bioscience-245	233	15	davitashvili	davitashvili	ADJ
bioscience-245	233	16	e	e	NOUN
bioscience-245	233	17	,	,	PUNCT
bioscience-245	233	18	solomonia	solomonia	NOUN
bioscience-245	233	19	r	r	NOUN
bioscience-245	233	20	,	,	PUNCT
bioscience-245	233	21	et	et	PROPN
bioscience-245	233	22	al	al	PROPN
bioscience-245	233	23	.	.	PROPN
bioscience-245	233	24	interplay	interplay	NOUN
bioscience-245	233	25	between	between	ADP
bioscience-245	233	26	nmda	nmda	ADJ
bioscience-245	233	27	receptor	receptor	NOUN
bioscience-245	233	28	modulation	modulation	NOUN
bioscience-245	233	29	and	and	CCONJ
bioscience-245	233	30	na	na	ADP
bioscience-245	233	31	/	/	SYM
bioscience-245	233	32	k	k	PROPN
bioscience-245	233	33	atpase	atpase	PROPN
bioscience-245	233	34	activityunder	activityunder	ADP
bioscience-245	233	35	the	the	DET
bioscience-245	233	36	social	social	ADJ
bioscience-245	233	37	isolation	isolation	NOUN
bioscience-245	233	38	-	-	PUNCT
bioscience-245	233	39	induced	induce	VERB
bioscience-245	233	40	stress	stress	NOUN
bioscience-245	233	41	in	in	ADP
bioscience-245	233	42	the	the	DET
bioscience-245	233	43	hippocampus	hippocampus	NOUN
bioscience-245	233	44	of	of	ADP
bioscience-245	233	45	male	male	ADJ
bioscience-245	233	46	rats	rat	NOUN
bioscience-245	233	47	.	.	PUNCT
bioscience-245	234	1	indian	indian	ADJ
bioscience-245	234	2	journal	journal	PROPN
bioscience-245	234	3	of	of	ADP
bioscience-245	234	4	biochemistry	biochemistry	NOUN
bioscience-245	234	5	biophysics	biophysic	NOUN
bioscience-245	234	6	.	.	PUNCT
bioscience-245	235	1	2024;61:32	2024;61:32	NUM
bioscience-245	235	2	.	.	PUNCT
bioscience-245	236	1	22	22	NUM
bioscience-245	236	2	.	.	PUNCT
bioscience-245	237	1	pervin	pervin	PROPN
bioscience-245	237	2	m	m	PROPN
bioscience-245	237	3	,	,	PUNCT
bioscience-245	237	4	unno	unno	PROPN
bioscience-245	237	5	k	k	PROPN
bioscience-245	237	6	,	,	PUNCT
bioscience-245	237	7	konishi	konishi	PROPN
bioscience-245	237	8	t	t	PROPN
bioscience-245	237	9	,	,	PUNCT
bioscience-245	237	10	nakamura	nakamura	PROPN
bioscience-245	237	11	y.	y.	PROPN
bioscience-245	237	12	l	l	PROPN
bioscience-245	237	13	-	-	NOUN
bioscience-245	237	14	arginine	arginine	NOUN
bioscience-245	237	15	exerts	exert	VERB
bioscience-245	237	16	excellent	excellent	ADJ
bioscience-245	237	17	anti	anti	ADJ
bioscience-245	237	18	-	-	ADJ
bioscience-245	237	19	stress	stress	ADJ
bioscience-245	237	20	effects	effect	NOUN
bioscience-245	237	21	on	on	ADP
bioscience-245	237	22	stress	stress	NOUN
bioscience-245	237	23	-	-	PUNCT
bioscience-245	237	24	induced	induce	VERB
bioscience-245	237	25	shortened	shorten	VERB
bioscience-245	237	26	lifespan	lifespan	NOUN
bioscience-245	237	27	,	,	PUNCT
bioscience-245	237	28	cognitive	cognitive	ADJ
bioscience-245	237	29	decline	decline	NOUN
bioscience-245	237	30	and	and	CCONJ
bioscience-245	237	31	depression	depression	NOUN
bioscience-245	237	32	.	.	PUNCT
bioscience-245	238	1	international	international	ADJ
bioscience-245	238	2	journal	journal	NOUN
bioscience-245	238	3	of	of	ADP
bioscience-245	238	4	molecular	molecular	ADJ
bioscience-245	238	5	sciences	science	NOUN
bioscience-245	238	6	.	.	PUNCT
bioscience-245	239	1	2021;22:508	2021;22:508	X
bioscience-245	239	2	.	.	PUNCT
bioscience-245	239	3	23	23	NUM
bioscience-245	239	4	.	.	PUNCT
bioscience-245	240	1	opmeer	opmeer	NOUN
bioscience-245	240	2	em	em	PRON
bioscience-245	240	3	,	,	PUNCT
bioscience-245	240	4	kortekaas	kortekaas	NOUN
bioscience-245	240	5	r	r	PROPN
bioscience-245	240	6	,	,	PUNCT
bioscience-245	240	7	aleman	aleman	NOUN
bioscience-245	240	8	a.	a.	NOUN
bioscience-245	240	9	depression	depression	NOUN
bioscience-245	240	10	and	and	CCONJ
bioscience-245	240	11	the	the	DET
bioscience-245	240	12	role	role	NOUN
bioscience-245	240	13	of	of	ADP
bioscience-245	240	14	genes	gene	NOUN
bioscience-245	240	15	involved	involve	VERB
bioscience-245	240	16	in	in	ADP
bioscience-245	240	17	dopamine	dopamine	NOUN
bioscience-245	240	18	metabolism	metabolism	NOUN
bioscience-245	240	19	and	and	CCONJ
bioscience-245	240	20	signalling	signal	VERB
bioscience-245	240	21	.	.	PUNCT
bioscience-245	241	1	progress	progress	NOUN
bioscience-245	241	2	in	in	ADP
bioscience-245	241	3	neurobiology	neurobiology	NOUN
bioscience-245	241	4	.	.	PUNCT
bioscience-245	242	1	2010;92:112	2010;92:112	X
bioscience-245	242	2	.	.	PROPN
bioscience-245	242	3	24	24	NUM
bioscience-245	242	4	.	.	PUNCT
bioscience-245	243	1	bekhbat	bekhbat	PROPN
bioscience-245	243	2	m	m	PROPN
bioscience-245	243	3	,	,	PUNCT
bioscience-245	243	4	li	li	PROPN
bioscience-245	243	5	z	z	PROPN
bioscience-245	243	6	,	,	PUNCT
bioscience-245	243	7	mehta	mehta	PROPN
bioscience-245	243	8	nd	nd	PROPN
bioscience-245	243	9	,	,	PUNCT
bioscience-245	243	10	treadway	treadway	PROPN
bioscience-245	243	11	m	m	PROPN
bioscience-245	243	12	,	,	PUNCT
bioscience-245	243	13	lucido	lucido	PROPN
bioscience-245	243	14	mj	mj	PROPN
bioscience-245	243	15	,	,	PUNCT
bioscience-245	243	16	woolwine	woolwine	VERB
bioscience-245	243	17	bj	bj	VERB
bioscience-245	243	18	,	,	PUNCT
bioscience-245	243	19	et	et	PROPN
bioscience-245	243	20	al	al	PROPN
bioscience-245	243	21	.	.	PROPN
bioscience-245	244	1	functional	functional	ADJ
bioscience-245	244	2	connectivity	connectivity	NOUN
bioscience-245	244	3	in	in	ADP
bioscience-245	244	4	reward	reward	NOUN
bioscience-245	244	5	circuitry	circuitry	NOUN
bioscience-245	244	6	and	and	CCONJ
bioscience-245	244	7	symptoms	symptom	NOUN
bioscience-245	244	8	of	of	ADP
bioscience-245	244	9	anhedonia	anhedonia	NOUN
bioscience-245	244	10	as	as	ADP
bioscience-245	244	11	therapeutic	therapeutic	ADJ
bioscience-245	244	12	targets	target	NOUN
bioscience-245	244	13	in	in	ADP
bioscience-245	244	14	depression	depression	NOUN
bioscience-245	244	15	with	with	ADP
bioscience-245	244	16	high	high	ADJ
bioscience-245	244	17	inflammation	inflammation	NOUN
bioscience-245	244	18	:	:	PUNCT
bioscience-245	244	19	evidence	evidence	NOUN
bioscience-245	244	20	from	from	ADP
bioscience-245	244	21	a	a	DET
bioscience-245	244	22	dopamine	dopamine	NOUN
bioscience-245	244	23	challenge	challenge	NOUN
bioscience-245	244	24	study	study	NOUN
bioscience-245	244	25	.	.	PUNCT
bioscience-245	245	1	molecular	molecular	ADJ
bioscience-245	245	2	psychiatry	psychiatry	NOUN
bioscience-245	245	3	.	.	PUNCT
bioscience-245	246	1	2022;27:4113	2022;27:4113	NUM
bioscience-245	246	2	.	.	NOUN
bioscience-245	246	3	25	25	NUM
bioscience-245	246	4	.	.	PUNCT
bioscience-245	247	1	tong	tong	PROPN
bioscience-245	247	2	bc	bc	PROPN
bioscience-245	247	3	,	,	PUNCT
bioscience-245	247	4	barbul	barbul	VERB
bioscience-245	247	5	a.	a.	NOUN
bioscience-245	247	6	cellular	cellular	ADJ
bioscience-245	247	7	and	and	CCONJ
bioscience-245	247	8	physiological	physiological	ADJ
bioscience-245	247	9	effects	effect	NOUN
bioscience-245	247	10	of	of	ADP
bioscience-245	247	11	arginine	arginine	NOUN
bioscience-245	247	12	.	.	PUNCT
bioscience-245	248	1	mini	mini	ADJ
bioscience-245	248	2	reviews	review	NOUN
bioscience-245	248	3	in	in	ADP
bioscience-245	248	4	medicinal	medicinal	ADJ
bioscience-245	248	5	chemistry	chemistry	NOUN
bioscience-245	248	6	.	.	PUNCT
bioscience-245	249	1	2004;4:823	2004;4:823	NUM
bioscience-245	249	2	.	.	NOUN
bioscience-245	250	1	26	26	NUM
bioscience-245	250	2	.	.	PUNCT
bioscience-245	251	1	gibbs	gibbs	PROPN
bioscience-245	251	2	sm	sm	PROPN
bioscience-245	251	3	.	.	PROPN
bioscience-245	251	4	regulation	regulation	NOUN
bioscience-245	251	5	of	of	ADP
bioscience-245	251	6	neuronal	neuronal	ADJ
bioscience-245	251	7	proliferation	proliferation	NOUN
bioscience-245	251	8	and	and	CCONJ
bioscience-245	251	9	differentiation	differentiation	NOUN
bioscience-245	251	10	by	by	ADP
bioscience-245	251	11	nitric	nitric	ADJ
bioscience-245	251	12	oxide	oxide	NOUN
bioscience-245	251	13	.	.	PUNCT
bioscience-245	252	1	molecular	molecular	ADJ
bioscience-245	252	2	neurobiology	neurobiology	NOUN
bioscience-245	252	3	.	.	PUNCT
bioscience-245	253	1	2003;27:107	2003;27:107	X
bioscience-245	253	2	.	.	X
bioscience-245	254	1	27	27	NUM
bioscience-245	254	2	.	.	PUNCT
bioscience-245	255	1	paul	paul	PROPN
bioscience-245	255	2	v	v	PROPN
bioscience-245	255	3	,	,	PUNCT
bioscience-245	255	4	ekambaram	ekambaram	PROPN
bioscience-245	255	5	p.	p.	NOUN
bioscience-245	255	6	involvement	involvement	NOUN
bioscience-245	255	7	of	of	ADP
bioscience-245	255	8	nitric	nitric	ADJ
bioscience-245	255	9	oxide	oxide	NOUN
bioscience-245	255	10	in	in	ADP
bioscience-245	255	11	learning	learn	VERB
bioscience-245	255	12	memory	memory	NOUN
bioscience-245	255	13	processes	process	NOUN
bioscience-245	255	14	.	.	PUNCT
bioscience-245	256	1	indian	indian	PROPN
bioscience-245	256	2	journal	journal	PROPN
bioscience-245	256	3	of	of	ADP
bioscience-245	256	4	medical	medical	ADJ
bioscience-245	256	5	research	research	NOUN
bioscience-245	256	6	.	.	PUNCT
bioscience-245	257	1	2011;133:471	2011;133:471	X
bioscience-245	257	2	.	.	PUNCT
bioscience-245	258	1	28	28	NUM
bioscience-245	258	2	.	.	PUNCT
bioscience-245	259	1	amini	amini	PROPN
bioscience-245	259	2	-	-	ADJ
bioscience-245	259	3	khoei	khoei	ADJ
bioscience-245	259	4	h	h	NOUN
bioscience-245	259	5	,	,	PUNCT
bioscience-245	259	6	boroujeni	boroujeni	PROPN
bioscience-245	259	7	s	s	PROPN
bioscience-245	259	8	,	,	PUNCT
bioscience-245	259	9	maghsoudi	maghsoudi	ADJ
bioscience-245	259	10	f	f	NOUN
bioscience-245	259	11	,	,	PUNCT
bioscience-245	259	12	rahimi	rahimi	ADJ
bioscience-245	259	13	-	-	PUNCT
bioscience-245	259	14	madiseh	madiseh	NOUN
bioscience-245	259	15	m	m	PROPN
bioscience-245	259	16	,	,	PUNCT
bioscience-245	259	17	bijad	bijad	PROPN
bioscience-245	259	18	e	e	NOUN
bioscience-245	259	19	,	,	PUNCT
bioscience-245	259	20	moradi	moradi	NOUN
bioscience-245	259	21	m	m	PROPN
bioscience-245	259	22	,	,	PUNCT
bioscience-245	259	23	et	et	PROPN
bioscience-245	259	24	al	al	PROPN
bioscience-245	259	25	.	.	PROPN
bioscience-245	260	1	possible	possible	ADJ
bioscience-245	260	2	involvement	involvement	NOUN
bioscience-245	260	3	of	of	ADP
bioscience-245	260	4	largininenitricoxide	largininenitricoxide	NOUN
bioscience-245	260	5	pathway	pathway	NOUN
bioscience-245	260	6	in	in	ADP
bioscience-245	260	7	the	the	DET
bioscience-245	260	8	antidepressant	antidepressant	ADJ
bioscience-245	260	9	activity	activity	NOUN
bioscience-245	260	10	of	of	ADP
bioscience-245	260	11	auraptene	auraptene	NOUN
bioscience-245	260	12	in	in	ADP
bioscience-245	260	13	mice	mouse	NOUN
bioscience-245	260	14	.	.	PUNCT
bioscience-245	261	1	behavioral	behavioral	ADJ
bioscience-245	261	2	and	and	CCONJ
bioscience-245	261	3	brain	brain	NOUN
bioscience-245	261	4	functions	function	NOUN
bioscience-245	261	5	.	.	PUNCT
bioscience-245	262	1	2022;18	2022;18	X
bioscience-245	262	2	.	.	NOUN
bioscience-245	262	3	29	29	NUM
bioscience-245	262	4	.	.	PUNCT
bioscience-245	262	5	kuchukashvili	kuchukashvili	PROPN
bioscience-245	262	6	z	z	PROPN
bioscience-245	262	7	,	,	PUNCT
bioscience-245	262	8	menabde	menabde	PROPN
bioscience-245	262	9	k	k	PROPN
bioscience-245	262	10	,	,	PUNCT
bioscience-245	262	11	chachua	chachua	PROPN
bioscience-245	262	12	m	m	PROPN
bioscience-245	262	13	,	,	PUNCT
bioscience-245	262	14	burjanadze	burjanadze	ADJ
bioscience-245	262	15	g	g	NOUN
bioscience-245	262	16	,	,	PUNCT
bioscience-245	262	17	chipashvili	chipashvili	NOUN
bioscience-245	262	18	m	m	NOUN
bioscience-245	262	19	,	,	PUNCT
bioscience-245	262	20	koshoridze	koshoridze	ADJ
bioscience-245	262	21	n.	n.	PROPN
bioscience-245	262	22	functional	functional	ADJ
bioscience-245	262	23	state	state	NOUN
bioscience-245	262	24	of	of	ADP
bioscience-245	262	25	rat	rat	NOUN
bioscience-245	262	26	cardiomyocytes	cardiomyocyte	NOUN
bioscience-245	262	27	and	and	CCONJ
bioscience-245	262	28	blood	blood	NOUN
bioscience-245	262	29	antioxidant	antioxidant	NOUN
bioscience-245	262	30	system	system	NOUN
bioscience-245	262	31	under	under	ADP
bioscience-245	262	32	psychoemotional	psychoemotional	ADJ
bioscience-245	262	33	stress	stress	NOUN
bioscience-245	262	34	.	.	PUNCT
bioscience-245	263	1	acta	acta	PROPN
bioscience-245	263	2	biochimica	biochimica	PROPN
bioscience-245	263	3	et	et	PROPN
bioscience-245	263	4	biophysica	biophysica	PROPN
bioscience-245	263	5	sinica	sinica	PROPN
bioscience-245	263	6	.	.	PUNCT
bioscience-245	264	1	2011;43:480	2011;43:480	NUM
bioscience-245	264	2	.	.	PUNCT
bioscience-245	265	1	30	30	NUM
bioscience-245	265	2	.	.	PUNCT
bioscience-245	266	1	amitai	amitai	PROPN
bioscience-245	266	2	y.	y.	PROPN
bioscience-245	266	3	physiologic	physiologic	ADJ
bioscience-245	266	4	role	role	NOUN
bioscience-245	266	5	for	for	ADP
bioscience-245	266	6	“	"	PUNCT
bioscience-245	266	7	inducible	inducible	ADJ
bioscience-245	266	8	”	"	PUNCT
bioscience-245	266	9	nitric	nitric	ADJ
bioscience-245	266	10	oxide	oxide	NOUN
bioscience-245	266	11	synthase	synthase	NOUN
bioscience-245	266	12	:	:	PUNCT
bioscience-245	266	13	a	a	DET
bioscience-245	266	14	new	new	ADJ
bioscience-245	266	15	form	form	NOUN
bioscience-245	266	16	of	of	ADP
bioscience-245	266	17	astrocytic	astrocytic	ADJ
bioscience-245	266	18	-	-	PUNCT
bioscience-245	266	19	neuronal	neuronal	ADJ
bioscience-245	266	20	interface	interface	NOUN
bioscience-245	266	21	.	.	PUNCT
bioscience-245	267	1	glia	glia	PROPN
bioscience-245	267	2	.	.	PUNCT
bioscience-245	268	1	2010;58:1775	2010;58:1775	X
bioscience-245	268	2	.	.	PUNCT
bioscience-245	269	1	31	31	NUM
bioscience-245	269	2	.	.	PUNCT
bioscience-245	270	1	maes	maes	PROPN
bioscience-245	270	2	m	m	PROPN
bioscience-245	270	3	,	,	PUNCT
bioscience-245	270	4	mihaylova	mihaylova	X
bioscience-245	270	5	l	l	NOUN
bioscience-245	270	6	,	,	PUNCT
bioscience-245	270	7	kubera	kubera	PROPN
bioscience-245	270	8	m	m	PROPN
bioscience-245	270	9	,	,	PUNCT
bioscience-245	270	10	uytterhoeven	uytterhoeven	PROPN
bioscience-245	270	11	m	m	PROPN
bioscience-245	270	12	,	,	PUNCT
bioscience-245	270	13	vrydags	vrydag	NOUN
bioscience-245	270	14	n	n	CCONJ
bioscience-245	270	15	,	,	PUNCT
bioscience-245	270	16	bosmans	bosmans	PROPN
bioscience-245	270	17	e.	e.	PROPN
bioscience-245	270	18	increased	increase	VERB
bioscience-245	270	19	plasma	plasma	NOUN
bioscience-245	270	20	peroxides	peroxide	NOUN
bioscience-245	270	21	and	and	CCONJ
bioscience-245	270	22	serum	serum	NOUN
bioscience-245	270	23	oxidized	oxidize	VERB
bioscience-245	270	24	low	low	ADJ
bioscience-245	270	25	density	density	NOUN
bioscience-245	270	26	lipoprotein	lipoprotein	ADJ
bioscience-245	270	27	antibodies	antibody	NOUN
bioscience-245	270	28	in	in	ADP
bioscience-245	270	29	major	major	ADJ
bioscience-245	270	30	depression	depression	NOUN
bioscience-245	270	31	:	:	PUNCT
bioscience-245	270	32	markers	marker	NOUN
bioscience-245	270	33	that	that	PRON
bioscience-245	270	34	further	far	ADV
bioscience-245	270	35	explain	explain	VERB
bioscience-245	270	36	the	the	DET
bioscience-245	270	37	higher	high	ADJ
bioscience-245	270	38	incidence	incidence	NOUN
bioscience-245	270	39	of	of	ADP
bioscience-245	270	40	neurodegeneration	neurodegeneration	NOUN
bioscience-245	270	41	and	and	CCONJ
bioscience-245	270	42	coronary	coronary	ADJ
bioscience-245	270	43	artery	artery	NOUN
bioscience-245	270	44	disease	disease	NOUN
bioscience-245	270	45	.	.	PUNCT
bioscience-245	271	1	journal	journal	PROPN
bioscience-245	271	2	of	of	ADP
bioscience-245	271	3	affective	affective	ADJ
bioscience-245	271	4	disorders	disorder	NOUN
bioscience-245	271	5	.	.	PUNCT
bioscience-245	272	1	2010;123:287	2010;123:287	X
bioscience-245	272	2	.	.	PUNCT
bioscience-245	273	1	highlights	highlight	NOUN
bioscience-245	273	2	in	in	ADP
bioscience-245	273	3	bioscience	bioscience	NOUN
bioscience-245	273	4	page	page	NOUN
bioscience-245	273	5	7	7	NUM
bioscience-245	273	6	of	of	ADP
bioscience-245	273	7	7	7	NUM
bioscience-245	273	8	june	june	PROPN
bioscience-245	273	9	2025|volume	2025|volume	NUM
bioscience-245	273	10	8	8	NUM
bioscience-245	273	11	http://bioscience.highlightsin.org/	http://bioscience.highlightsin.org/	PRON
bioscience-245	273	12	abstract	abstract	ADJ
bioscience-245	273	13	introduction	introduction	NOUN
bioscience-245	273	14	materials	material	NOUN
bioscience-245	273	15	and	and	CCONJ
bioscience-245	273	16	methods	method	NOUN
bioscience-245	273	17	ethics	ethic	NOUN
bioscience-245	273	18	approval	approval	NOUN
bioscience-245	273	19	animals	animal	NOUN
bioscience-245	273	20	and	and	CCONJ
bioscience-245	273	21	housing	housing	NOUN
bioscience-245	273	22	conditions	condition	NOUN
bioscience-245	273	23	behavioral	behavioral	ADJ
bioscience-245	273	24	assessments	assessment	NOUN
bioscience-245	273	25	and	and	CCONJ
bioscience-245	273	26	biochemical	biochemical	ADJ
bioscience-245	273	27	analysis	analysis	NOUN
bioscience-245	273	28	statistical	statistical	ADJ
bioscience-245	273	29	analysis	analysis	NOUN
bioscience-245	273	30	results	result	VERB
bioscience-245	273	31	behavioral	behavioral	ADJ
bioscience-245	273	32	effects	effect	NOUN
bioscience-245	273	33	of	of	ADP
bioscience-245	273	34	l	l	NOUN
bioscience-245	273	35	-	-	NOUN
bioscience-245	273	36	arginine	arginine	NOUN
bioscience-245	273	37	in	in	ADP
bioscience-245	273	38	a	a	DET
bioscience-245	273	39	corticosterone	corticosterone	NOUN
bioscience-245	273	40	-	-	PUNCT
bioscience-245	273	41	induced	induce	VERB
bioscience-245	273	42	depression	depression	NOUN
bioscience-245	273	43	model	model	NOUN
bioscience-245	273	44	effect	effect	NOUN
bioscience-245	273	45	of	of	ADP
bioscience-245	273	46	l	l	NOUN
bioscience-245	273	47	-	-	NOUN
bioscience-245	273	48	arginine	arginine	NOUN
bioscience-245	273	49	on	on	ADP
bioscience-245	273	50	the	the	DET
bioscience-245	273	51	hormonal	hormonal	ADJ
bioscience-245	273	52	status	status	NOUN
bioscience-245	273	53	of	of	ADP
bioscience-245	273	54	depressed	depressed	ADJ
bioscience-245	273	55	animals	animal	NOUN
bioscience-245	273	56	effect	effect	NOUN
bioscience-245	273	57	of	of	ADP
bioscience-245	273	58	l	l	NOUN
bioscience-245	273	59	-	-	NOUN
bioscience-245	273	60	arginine	arginine	NOUN
bioscience-245	273	61	on	on	ADP
bioscience-245	273	62	nitric	nitric	ADJ
bioscience-245	273	63	oxide	oxide	NOUN
bioscience-245	273	64	and	and	CCONJ
bioscience-245	273	65	malondialdehyde	malondialdehyde	NOUN
bioscience-245	273	66	levels	level	NOUN
bioscience-245	273	67	in	in	ADP
bioscience-245	273	68	the	the	DET
bioscience-245	273	69	brain	brain	NOUN
bioscience-245	273	70	cells	cell	NOUN
bioscience-245	273	71	of	of	ADP
bioscience-245	273	72	depressed	depressed	ADJ
bioscience-245	273	73	animals	animal	NOUN
bioscience-245	273	74	changes	change	NOUN
bioscience-245	273	75	in	in	ADP
bioscience-245	273	76	malondialdehyde	malondialdehyde	NOUN
bioscience-245	273	77	levels	level	NOUN
bioscience-245	273	78	effect	effect	NOUN
bioscience-245	273	79	of	of	ADP
bioscience-245	273	80	l	l	NOUN
bioscience-245	273	81	-	-	NOUN
bioscience-245	273	82	arginine	arginine	NOUN
bioscience-245	273	83	on	on	ADP
bioscience-245	273	84	the	the	DET
bioscience-245	273	85	activity	activity	NOUN
bioscience-245	273	86	of	of	ADP
bioscience-245	273	87	antioxidant	antioxidant	ADJ
bioscience-245	273	88	enzymes	enzyme	NOUN
bioscience-245	273	89	in	in	ADP
bioscience-245	273	90	depressed	depressed	ADJ
bioscience-245	273	91	animals	animal	NOUN
bioscience-245	273	92	kinetics	kinetic	NOUN
bioscience-245	273	93	of	of	ADP
bioscience-245	273	94	sod	sod	NOUN
bioscience-245	273	95	and	and	CCONJ
bioscience-245	273	96	catalase	catalase	NOUN
bioscience-245	273	97	and	and	CCONJ
bioscience-245	273	98	the	the	DET
bioscience-245	273	99	effect	effect	NOUN
bioscience-245	273	100	of	of	ADP
bioscience-245	273	101	l	l	NOUN
bioscience-245	273	102	-	-	PUNCT
bioscience-245	273	103	arginine	arginine	NOUN
bioscience-245	273	104	discussion	discussion	NOUN
bioscience-245	273	105	conclusion	conclusion	NOUN
bioscience-245	273	106	acknowledgements	acknowledgement	NOUN