id	sid	tid	token	lemma	pos
hjic-110	1	1	microsoft	microsoft	PROPN
hjic-110	1	2	word	word	NOUN
hjic-110	1	3	contents.doc	contents.doc	X
hjic-110	1	4	hungarian	hungarian	ADJ
hjic-110	1	5	journal	journal	NOUN
hjic-110	1	6	of	of	ADP
hjic-110	1	7	industrial	industrial	ADJ
hjic-110	1	8	chemistry	chemistry	NOUN
hjic-110	1	9	veszprém	veszprém	NOUN
hjic-110	1	10	vol	vol	NOUN
hjic-110	1	11	.	.	PUNCT
hjic-110	2	1	34	34	NUM
hjic-110	2	2	.	.	PUNCT
hjic-110	3	1	pp	pp	ADJ
hjic-110	3	2	.	.	PUNCT
hjic-110	4	1	41	41	NUM
hjic-110	4	2	-	-	SYM
hjic-110	4	3	49	49	NUM
hjic-110	4	4	(	(	PUNCT
hjic-110	4	5	2006	2006	NUM
hjic-110	4	6	)	)	PUNCT
hjic-110	4	7	solid	solid	ADJ
hjic-110	4	8	dispersions	dispersion	NOUN
hjic-110	4	9	of	of	ADP
hjic-110	4	10	oxeglitazar	oxeglitazar	NOUN
hjic-110	4	11	in	in	ADP
hjic-110	4	12	pvp	pvp	PROPN
hjic-110	4	13	k17	k17	PROPN
hjic-110	4	14	and	and	CCONJ
hjic-110	4	15	poloxamer	poloxamer	PROPN
hjic-110	4	16	407	407	NUM
hjic-110	4	17	by	by	ADP
hjic-110	4	18	supercritical	supercritical	ADJ
hjic-110	4	19	antisolvent	antisolvent	NOUN
hjic-110	4	20	and	and	CCONJ
hjic-110	4	21	coevaporation	coevaporation	NOUN
hjic-110	4	22	methods	method	NOUN
hjic-110	4	23	v.	v.	ADP
hjic-110	4	24	majerik1	majerik1	PROPN
hjic-110	4	25	,	,	PUNCT
hjic-110	4	26	g.	g.	PROPN
hjic-110	4	27	horváth1	horváth1	PROPN
hjic-110	4	28	,	,	PUNCT
hjic-110	4	29	g.	g.	PROPN
hjic-110	4	30	charbit2	charbit2	PROPN
hjic-110	4	31	,	,	PUNCT
hjic-110	4	32	e.	e.	PROPN
hjic-110	4	33	badens2	badens2	PROPN
hjic-110	4	34	,	,	PUNCT
hjic-110	4	35	l.	l.	PROPN
hjic-110	4	36	szokonya1	szokonya1	PROPN
hjic-110	4	37	,	,	PUNCT
hjic-110	4	38	n.	n.	PROPN
hjic-110	4	39	bosc3	bosc3	PROPN
hjic-110	4	40	and	and	CCONJ
hjic-110	4	41	e.	e.	PROPN
hjic-110	4	42	teillaud3	teillaud3	PROPN
hjic-110	4	43	1department	1department	NUM
hjic-110	4	44	of	of	ADP
hjic-110	4	45	chemical	chemical	NOUN
hjic-110	4	46	engineering	engineering	NOUN
hjic-110	4	47	science	science	NOUN
hjic-110	4	48	,	,	PUNCT
hjic-110	4	49	university	university	NOUN
hjic-110	4	50	of	of	ADP
hjic-110	4	51	pannonia	pannonia	PROPN
hjic-110	4	52	,	,	PUNCT
hjic-110	4	53	veszprém	veszprém	NOUN
hjic-110	4	54	egyetem	egyetem	PROPN
hjic-110	4	55	u.	u.	PROPN
hjic-110	4	56	10	10	NUM
hjic-110	4	57	po	po	PROPN
hjic-110	4	58	box	box	PROPN
hjic-110	4	59	158	158	NUM
hjic-110	4	60	,	,	PUNCT
hjic-110	4	61	h-8201	h-8201	PROPN
hjic-110	4	62	,	,	PUNCT
hjic-110	4	63	hungary	hungary	NOUN
hjic-110	4	64	e	e	NOUN
hjic-110	4	65	-	-	NOUN
hjic-110	4	66	mail	mail	NOUN
hjic-110	4	67	:	:	PUNCT
hjic-110	4	68	majerikv@almos.vein.hu	majerikv@almos.vein.hu	PROPN
hjic-110	4	69	2laboratoire	2laboratoire	NUM
hjic-110	4	70	de	de	X
hjic-110	4	71	procédés	procédés	PROPN
hjic-110	4	72	propres	propre	NOUN
hjic-110	4	73	et	et	PROPN
hjic-110	4	74	environnement	environnement	PROPN
hjic-110	4	75	,	,	PUNCT
hjic-110	4	76	umr6181	umr6181	PROPN
hjic-110	4	77	université	université	PROPN
hjic-110	4	78	paul	paul	PROPN
hjic-110	4	79	cézanne	cézanne	PROPN
hjic-110	4	80	aix	aix	PROPN
hjic-110	4	81	-	-	PUNCT
hjic-110	4	82	marseille	marseille	NOUN
hjic-110	4	83	3	3	NUM
hjic-110	4	84	,	,	PUNCT
hjic-110	4	85	europôle	europôle	X
hjic-110	4	86	de	de	X
hjic-110	4	87	l'arbois	l'arbois	PROPN
hjic-110	4	88	bp	bp	PROPN
hjic-110	4	89	80	80	NUM
hjic-110	4	90	13545	13545	NUM
hjic-110	4	91	aix	aix	PROPN
hjic-110	4	92	en	en	PROPN
hjic-110	4	93	provence	provence	PROPN
hjic-110	4	94	cedex	cedex	PROPN
hjic-110	4	95	4	4	NUM
hjic-110	4	96	,	,	PUNCT
hjic-110	4	97	france	france	PROPN
hjic-110	4	98	3	3	NUM
hjic-110	4	99	merck	merck	PROPN
hjic-110	4	100	santé	santé	PROPN
hjic-110	4	101	sas	sas	PROPN
hjic-110	4	102	,	,	PUNCT
hjic-110	4	103	37	37	NUM
hjic-110	4	104	rue	rue	PROPN
hjic-110	4	105	st	st	PROPN
hjic-110	4	106	romain	romain	PROPN
hjic-110	4	107	69379	69379	NUM
hjic-110	4	108	lyon	lyon	PROPN
hjic-110	4	109	cedex	cedex	PROPN
hjic-110	4	110	08	08	PROPN
hjic-110	4	111	,	,	PUNCT
hjic-110	4	112	france	france	PROPN
hjic-110	4	113	the	the	DET
hjic-110	4	114	objective	objective	NOUN
hjic-110	4	115	of	of	ADP
hjic-110	4	116	this	this	DET
hjic-110	4	117	work	work	NOUN
hjic-110	4	118	was	be	AUX
hjic-110	4	119	to	to	PART
hjic-110	4	120	improve	improve	VERB
hjic-110	4	121	the	the	DET
hjic-110	4	122	dissolution	dissolution	NOUN
hjic-110	4	123	rate	rate	NOUN
hjic-110	4	124	and	and	CCONJ
hjic-110	4	125	aqueous	aqueous	ADJ
hjic-110	4	126	solubility	solubility	NOUN
hjic-110	4	127	of	of	ADP
hjic-110	4	128	oxeglitazar	oxeglitazar	NOUN
hjic-110	4	129	.	.	PUNCT
hjic-110	5	1	solid	solid	ADJ
hjic-110	5	2	dispersions	dispersion	NOUN
hjic-110	5	3	of	of	ADP
hjic-110	5	4	oxeglitazar	oxeglitazar	NOUN
hjic-110	5	5	in	in	ADP
hjic-110	5	6	pvp	pvp	PROPN
hjic-110	5	7	k17	k17	PROPN
hjic-110	5	8	(	(	PUNCT
hjic-110	5	9	polyvinilpyrrolidone	polyvinilpyrrolidone	NOUN
hjic-110	5	10	)	)	PUNCT
hjic-110	5	11	and	and	CCONJ
hjic-110	5	12	poloxamer	poloxamer	NOUN
hjic-110	5	13	407	407	NUM
hjic-110	5	14	(	(	PUNCT
hjic-110	5	15	polyoxyethylene	polyoxyethylene	NOUN
hjic-110	5	16	-	-	PUNCT
hjic-110	5	17	polyoxypropylene	polyoxypropylene	NOUN
hjic-110	5	18	block	block	NOUN
hjic-110	5	19	copolymer	copolymer	NOUN
hjic-110	5	20	)	)	PUNCT
hjic-110	5	21	were	be	AUX
hjic-110	5	22	prepared	prepare	VERB
hjic-110	5	23	by	by	ADP
hjic-110	5	24	supercritical	supercritical	ADJ
hjic-110	5	25	antisolvent	antisolvent	NOUN
hjic-110	5	26	(	(	PUNCT
hjic-110	5	27	sas	sas	PROPN
hjic-110	5	28	)	)	PUNCT
hjic-110	5	29	and	and	CCONJ
hjic-110	5	30	coevaporation	coevaporation	NOUN
hjic-110	5	31	(	(	PUNCT
hjic-110	5	32	coe	coe	PROPN
hjic-110	5	33	)	)	PUNCT
hjic-110	5	34	methods	method	NOUN
hjic-110	5	35	.	.	PUNCT
hjic-110	6	1	drug	drug	NOUN
hjic-110	6	2	-	-	PUNCT
hjic-110	6	3	carrier	carrier	NOUN
hjic-110	6	4	formulations	formulation	NOUN
hjic-110	6	5	were	be	AUX
hjic-110	6	6	characterized	characterize	VERB
hjic-110	6	7	by	by	ADP
hjic-110	6	8	powder	powder	NOUN
hjic-110	6	9	x	x	NOUN
hjic-110	6	10	-	-	NOUN
hjic-110	6	11	ray	ray	NOUN
hjic-110	6	12	diffraction	diffraction	NOUN
hjic-110	6	13	,	,	PUNCT
hjic-110	6	14	fourier	fourier	NOUN
hjic-110	6	15	transform	transform	VERB
hjic-110	6	16	infrared	infrared	ADJ
hjic-110	6	17	spectroscopy	spectroscopy	NOUN
hjic-110	6	18	,	,	PUNCT
hjic-110	6	19	scanning	scan	VERB
hjic-110	6	20	electron	electron	NOUN
hjic-110	6	21	microscopy	microscopy	NOUN
hjic-110	6	22	,	,	PUNCT
hjic-110	6	23	gas	gas	NOUN
hjic-110	6	24	chromatography	chromatography	NOUN
hjic-110	6	25	,	,	PUNCT
hjic-110	6	26	uv	uv	NOUN
hjic-110	6	27	/	/	SYM
hjic-110	6	28	vis	vis	X
hjic-110	6	29	spectroscopy	spectroscopy	NOUN
hjic-110	6	30	and	and	CCONJ
hjic-110	6	31	in	in	ADP
hjic-110	6	32	vitro	vitro	X
hjic-110	6	33	dissolution	dissolution	NOUN
hjic-110	6	34	tests	test	NOUN
hjic-110	6	35	.	.	PUNCT
hjic-110	7	1	the	the	DET
hjic-110	7	2	highest	high	ADJ
hjic-110	7	3	dissolution	dissolution	ADJ
hjic-110	7	4	rate	rate	NOUN
hjic-110	7	5	(	(	PUNCT
hjic-110	7	6	nearly	nearly	ADV
hjic-110	7	7	3	3	NUM
hjic-110	7	8	-	-	NOUN
hjic-110	7	9	fold	fold	VERB
hjic-110	7	10	higher	high	ADJ
hjic-110	7	11	than	than	ADP
hjic-110	7	12	raw	raw	ADJ
hjic-110	7	13	drug	drug	NOUN
hjic-110	7	14	)	)	PUNCT
hjic-110	7	15	was	be	AUX
hjic-110	7	16	achieved	achieve	VERB
hjic-110	7	17	by	by	ADP
hjic-110	7	18	preparation	preparation	NOUN
hjic-110	7	19	of	of	ADP
hjic-110	7	20	drug	drug	NOUN
hjic-110	7	21	/	/	SYM
hjic-110	7	22	pvp	pvp	PROPN
hjic-110	7	23	k17	k17	PROPN
hjic-110	7	24	coevaporate	coevaporate	NOUN
hjic-110	7	25	.	.	PUNCT
hjic-110	8	1	oxeglitazar	oxeglitazar	PROPN
hjic-110	8	2	/	/	SYM
hjic-110	8	3	pvp	pvp	PROPN
hjic-110	8	4	k17	k17	PROPN
hjic-110	8	5	solid	solid	ADJ
hjic-110	8	6	dispersions	dispersion	NOUN
hjic-110	8	7	were	be	AUX
hjic-110	8	8	stabilized	stabilize	VERB
hjic-110	8	9	by	by	ADP
hjic-110	8	10	hydrogen	hydrogen	NOUN
hjic-110	8	11	bonding	bonding	NOUN
hjic-110	8	12	but	but	CCONJ
hjic-110	8	13	contained	contain	VERB
hjic-110	8	14	higher	high	ADJ
hjic-110	8	15	amount	amount	NOUN
hjic-110	8	16	of	of	ADP
hjic-110	8	17	residual	residual	ADJ
hjic-110	8	18	dcm	dcm	NOUN
hjic-110	8	19	than	than	ADP
hjic-110	8	20	poloxamer	poloxamer	NOUN
hjic-110	8	21	407	407	NUM
hjic-110	8	22	formulations	formulation	NOUN
hjic-110	8	23	regardless	regardless	ADV
hjic-110	8	24	of	of	ADP
hjic-110	8	25	the	the	DET
hjic-110	8	26	method	method	NOUN
hjic-110	8	27	of	of	ADP
hjic-110	8	28	preparation	preparation	NOUN
hjic-110	8	29	.	.	PUNCT
hjic-110	9	1	sas	sas	PROPN
hjic-110	9	2	prepared	prepare	VERB
hjic-110	9	3	oxeglitazar	oxeglitazar	NOUN
hjic-110	9	4	/	/	SYM
hjic-110	9	5	poloxamer	poloxamer	NOUN
hjic-110	9	6	407	407	NUM
hjic-110	9	7	dissolved	dissolve	VERB
hjic-110	9	8	more	more	ADJ
hjic-110	9	9	than	than	ADP
hjic-110	9	10	two	two	NUM
hjic-110	9	11	times	time	NOUN
hjic-110	9	12	faster	fast	ADJ
hjic-110	9	13	than	than	ADP
hjic-110	9	14	raw	raw	ADJ
hjic-110	9	15	drug	drug	NOUN
hjic-110	9	16	.	.	PUNCT
hjic-110	10	1	however	however	ADV
hjic-110	10	2	,	,	PUNCT
hjic-110	10	3	unlike	unlike	ADP
hjic-110	10	4	pvp	pvp	PROPN
hjic-110	10	5	k17	k17	PROPN
hjic-110	10	6	,	,	PUNCT
hjic-110	10	7	poloxamer	poloxamer	PROPN
hjic-110	10	8	407	407	NUM
hjic-110	10	9	did	do	AUX
hjic-110	10	10	not	not	PART
hjic-110	10	11	form	form	VERB
hjic-110	10	12	a	a	DET
hjic-110	10	13	single	single	ADJ
hjic-110	10	14	phase	phase	NOUN
hjic-110	10	15	amorphous	amorphous	ADJ
hjic-110	10	16	solid	solid	ADJ
hjic-110	10	17	solution	solution	NOUN
hjic-110	10	18	with	with	ADP
hjic-110	10	19	oxeglitazar	oxeglitazar	NOUN
hjic-110	10	20	which	which	PRON
hjic-110	10	21	has	have	AUX
hjic-110	10	22	been	be	AUX
hjic-110	10	23	manifested	manifest	VERB
hjic-110	10	24	in	in	ADP
hjic-110	10	25	higher	high	ADJ
hjic-110	10	26	degrees	degree	NOUN
hjic-110	10	27	of	of	ADP
hjic-110	10	28	crystallinity	crystallinity	NOUN
hjic-110	10	29	,	,	PUNCT
hjic-110	10	30	too	too	ADV
hjic-110	10	31	.	.	PUNCT
hjic-110	11	1	among	among	ADP
hjic-110	11	2	the	the	DET
hjic-110	11	3	two	two	NUM
hjic-110	11	4	techniques	technique	NOUN
hjic-110	11	5	,	,	PUNCT
hjic-110	11	6	evaluated	evaluate	VERB
hjic-110	11	7	in	in	ADP
hjic-110	11	8	this	this	DET
hjic-110	11	9	work	work	NOUN
hjic-110	11	10	,	,	PUNCT
hjic-110	11	11	conventional	conventional	ADJ
hjic-110	11	12	coevaporation	coevaporation	NOUN
hjic-110	11	13	resulted	result	VERB
hjic-110	11	14	in	in	ADP
hjic-110	11	15	higher	high	ADJ
hjic-110	11	16	amorphous	amorphous	ADJ
hjic-110	11	17	content	content	NOUN
hjic-110	11	18	but	but	CCONJ
hjic-110	11	19	sas	sa	VERB
hjic-110	11	20	reduced	reduce	VERB
hjic-110	11	21	residual	residual	ADJ
hjic-110	11	22	solvent	solvent	NOUN
hjic-110	11	23	content	content	NOUN
hjic-110	11	24	more	more	ADV
hjic-110	11	25	efficiently	efficiently	ADV
hjic-110	11	26	.	.	PUNCT
hjic-110	12	1	keywords	keyword	NOUN
hjic-110	12	2	:	:	PUNCT
hjic-110	12	3	solid	solid	ADJ
hjic-110	12	4	dispersion	dispersion	NOUN
hjic-110	12	5	,	,	PUNCT
hjic-110	12	6	poorly	poorly	ADV
hjic-110	12	7	water	water	NOUN
hjic-110	12	8	soluble	soluble	ADJ
hjic-110	12	9	drug	drug	NOUN
hjic-110	12	10	,	,	PUNCT
hjic-110	12	11	oxeglitazar	oxeglitazar	NOUN
hjic-110	12	12	,	,	PUNCT
hjic-110	12	13	supercritical	supercritical	ADJ
hjic-110	12	14	antisolvent	antisolvent	NOUN
hjic-110	12	15	,	,	PUNCT
hjic-110	12	16	coevaporation	coevaporation	NOUN
hjic-110	12	17	,	,	PUNCT
hjic-110	12	18	introduction	introduction	NOUN
hjic-110	12	19	oxeglitazar	oxeglitazar	NOUN
hjic-110	12	20	belongs	belong	VERB
hjic-110	12	21	to	to	ADP
hjic-110	12	22	a	a	DET
hjic-110	12	23	new	new	ADJ
hjic-110	12	24	class	class	NOUN
hjic-110	12	25	of	of	ADP
hjic-110	12	26	diabetes	diabetes	NOUN
hjic-110	12	27	drugs	drug	NOUN
hjic-110	12	28	,	,	PUNCT
hjic-110	12	29	the	the	DET
hjic-110	12	30	dual	dual	ADJ
hjic-110	12	31	peroxisome	peroxisome	VERB
hjic-110	12	32	proliferative	proliferative	ADJ
hjic-110	12	33	activator	activator	NOUN
hjic-110	12	34	receptor	receptor	NOUN
hjic-110	12	35	(	(	PUNCT
hjic-110	12	36	ppar	ppar	NOUN
hjic-110	12	37	)	)	PUNCT
hjic-110	12	38	agonists	agonist	NOUN
hjic-110	12	39	,	,	PUNCT
hjic-110	12	40	collectively	collectively	ADV
hjic-110	12	41	known	know	VERB
hjic-110	12	42	as	as	ADP
hjic-110	12	43	the	the	DET
hjic-110	12	44	glitazars	glitazar	NOUN
hjic-110	12	45	(	(	PUNCT
hjic-110	12	46	fig	fig	NOUN
hjic-110	12	47	.	.	NOUN
hjic-110	13	1	1	1	NUM
hjic-110	13	2	)	)	PUNCT
hjic-110	14	1	[	[	X
hjic-110	14	2	1	1	NUM
hjic-110	14	3	]	]	PUNCT
hjic-110	14	4	.	.	PUNCT
hjic-110	15	1	as	as	ADP
hjic-110	15	2	an	an	DET
hjic-110	15	3	orally	orally	ADV
hjic-110	15	4	administered	administer	VERB
hjic-110	15	5	active	active	ADJ
hjic-110	15	6	pharmaceutical	pharmaceutical	ADJ
hjic-110	15	7	ingredient	ingredient	NOUN
hjic-110	15	8	(	(	PUNCT
hjic-110	15	9	api	api	NOUN
hjic-110	15	10	)	)	PUNCT
hjic-110	15	11	the	the	DET
hjic-110	15	12	bioavailability	bioavailability	NOUN
hjic-110	15	13	of	of	ADP
hjic-110	15	14	oxeglitazar	oxeglitazar	NOUN
hjic-110	15	15	depends	depend	VERB
hjic-110	15	16	on	on	ADP
hjic-110	15	17	its	its	PRON
hjic-110	15	18	solubility	solubility	NOUN
hjic-110	15	19	and	and	CCONJ
hjic-110	15	20	permeability	permeability	NOUN
hjic-110	15	21	in	in	ADP
hjic-110	15	22	the	the	DET
hjic-110	15	23	gastrointestinal	gastrointestinal	ADJ
hjic-110	15	24	(	(	PUNCT
hjic-110	15	25	gi	gi	NOUN
hjic-110	15	26	)	)	PUNCT
hjic-110	15	27	tract	tract	NOUN
hjic-110	15	28	[	[	X
hjic-110	15	29	2	2	NUM
hjic-110	15	30	]	]	PUNCT
hjic-110	15	31	.	.	PUNCT
hjic-110	16	1	initial	initial	ADJ
hjic-110	16	2	studies	study	NOUN
hjic-110	16	3	found	find	VERB
hjic-110	16	4	that	that	SCONJ
hjic-110	16	5	the	the	DET
hjic-110	16	6	absorption	absorption	NOUN
hjic-110	16	7	of	of	ADP
hjic-110	16	8	oxeglitazar	oxeglitazar	NOUN
hjic-110	16	9	is	be	AUX
hjic-110	16	10	limited	limit	VERB
hjic-110	16	11	by	by	ADP
hjic-110	16	12	its	its	PRON
hjic-110	16	13	poor	poor	ADJ
hjic-110	16	14	solubility	solubility	NOUN
hjic-110	16	15	and	and	CCONJ
hjic-110	16	16	dissolution	dissolution	NOUN
hjic-110	16	17	rate	rate	NOUN
hjic-110	16	18	.	.	PUNCT
hjic-110	17	1	the	the	DET
hjic-110	17	2	api	api	NOUN
hjic-110	17	3	has	have	VERB
hjic-110	17	4	to	to	PART
hjic-110	17	5	dissolve	dissolve	VERB
hjic-110	17	6	in	in	ADP
hjic-110	17	7	the	the	DET
hjic-110	17	8	gi	gi	NOUN
hjic-110	17	9	fluid	fluid	NOUN
hjic-110	17	10	prior	prior	ADV
hjic-110	17	11	to	to	ADP
hjic-110	17	12	absorption	absorption	NOUN
hjic-110	17	13	but	but	CCONJ
hjic-110	17	14	such	such	ADJ
hjic-110	17	15	drugs	drug	NOUN
hjic-110	17	16	remain	remain	VERB
hjic-110	17	17	in	in	ADP
hjic-110	17	18	suspension	suspension	NOUN
hjic-110	17	19	and	and	CCONJ
hjic-110	17	20	can	can	AUX
hjic-110	17	21	not	not	PART
hjic-110	17	22	cross	cross	VERB
hjic-110	17	23	the	the	DET
hjic-110	17	24	membranes	membrane	NOUN
hjic-110	17	25	of	of	ADP
hjic-110	17	26	the	the	DET
hjic-110	17	27	epithelial	epithelial	ADJ
hjic-110	17	28	cells	cell	NOUN
hjic-110	17	29	in	in	ADP
hjic-110	17	30	the	the	DET
hjic-110	17	31	gi	gi	NOUN
hjic-110	17	32	tract	tract	NOUN
hjic-110	17	33	.	.	PUNCT
hjic-110	18	1	solubility	solubility	NOUN
hjic-110	18	2	enhancement	enhancement	NOUN
hjic-110	18	3	of	of	ADP
hjic-110	18	4	hydrophobic	hydrophobic	NOUN
hjic-110	18	5	active	active	ADJ
hjic-110	18	6	substances	substance	NOUN
hjic-110	18	7	is	be	AUX
hjic-110	18	8	an	an	DET
hjic-110	18	9	important	important	ADJ
hjic-110	18	10	area	area	NOUN
hjic-110	18	11	of	of	ADP
hjic-110	18	12	drug	drug	NOUN
hjic-110	18	13	delivery	delivery	NOUN
hjic-110	18	14	science	science	NOUN
hjic-110	18	15	because	because	SCONJ
hjic-110	18	16	one	one	NUM
hjic-110	18	17	out	out	ADP
hjic-110	18	18	of	of	ADP
hjic-110	18	19	four	four	NUM
hjic-110	18	20	orally	orally	ADV
hjic-110	18	21	administered	administer	VERB
hjic-110	18	22	apis	apis	PROPN
hjic-110	18	23	is	be	AUX
hjic-110	18	24	concerned	concern	VERB
hjic-110	18	25	[	[	X
hjic-110	18	26	3	3	NUM
hjic-110	18	27	]	]	PUNCT
hjic-110	18	28	.	.	PUNCT
hjic-110	19	1	to	to	PART
hjic-110	19	2	overcome	overcome	VERB
hjic-110	19	3	these	these	DET
hjic-110	19	4	difficulties	difficulty	NOUN
hjic-110	19	5	,	,	PUNCT
hjic-110	19	6	new	new	ADJ
hjic-110	19	7	formulation	formulation	NOUN
hjic-110	19	8	techniques	technique	NOUN
hjic-110	19	9	were	be	AUX
hjic-110	19	10	developed	develop	VERB
hjic-110	19	11	comprising	comprising	NOUN
hjic-110	19	12	micronization	micronization	NOUN
hjic-110	19	13	,	,	PUNCT
hjic-110	19	14	surface	surface	NOUN
hjic-110	19	15	modification	modification	NOUN
hjic-110	19	16	,	,	PUNCT
hjic-110	19	17	formation	formation	NOUN
hjic-110	19	18	of	of	ADP
hjic-110	19	19	complexes	complex	NOUN
hjic-110	19	20	,	,	PUNCT
hjic-110	19	21	solvates	solvate	NOUN
hjic-110	19	22	,	,	PUNCT
hjic-110	19	23	solid	solid	ADJ
hjic-110	19	24	solutions	solution	NOUN
hjic-110	19	25	and	and	CCONJ
hjic-110	19	26	solid	solid	ADJ
hjic-110	19	27	dispersions	dispersion	NOUN
hjic-110	19	28	.	.	PUNCT
hjic-110	20	1	micronization	micronization	NOUN
hjic-110	20	2	is	be	AUX
hjic-110	20	3	an	an	DET
hjic-110	20	4	attractive	attractive	ADJ
hjic-110	20	5	method	method	NOUN
hjic-110	20	6	because	because	SCONJ
hjic-110	20	7	no	no	DET
hjic-110	20	8	additional	additional	ADJ
hjic-110	20	9	excipient	excipient	NOUN
hjic-110	20	10	is	be	AUX
hjic-110	20	11	needed	need	VERB
hjic-110	20	12	but	but	CCONJ
hjic-110	20	13	it	it	PRON
hjic-110	20	14	improves	improve	VERB
hjic-110	20	15	only	only	ADV
hjic-110	20	16	the	the	DET
hjic-110	20	17	dissolution	dissolution	NOUN
hjic-110	20	18	rate	rate	NOUN
hjic-110	20	19	by	by	ADP
hjic-110	20	20	increasing	increase	VERB
hjic-110	20	21	the	the	DET
hjic-110	20	22	specific	specific	ADJ
hjic-110	20	23	surface	surface	NOUN
hjic-110	20	24	area	area	NOUN
hjic-110	20	25	and	and	CCONJ
hjic-110	20	26	has	have	VERB
hjic-110	20	27	no	no	DET
hjic-110	20	28	effect	effect	NOUN
hjic-110	20	29	on	on	ADP
hjic-110	20	30	the	the	DET
hjic-110	20	31	solubility	solubility	NOUN
hjic-110	20	32	.	.	PUNCT
hjic-110	21	1	in	in	ADP
hjic-110	21	2	contrast	contrast	NOUN
hjic-110	21	3	,	,	PUNCT
hjic-110	21	4	excipients	excipient	NOUN
hjic-110	21	5	were	be	AUX
hjic-110	21	6	shown	show	VERB
hjic-110	21	7	to	to	PART
hjic-110	21	8	increase	increase	VERB
hjic-110	21	9	both	both	DET
hjic-110	21	10	dissolution	dissolution	ADJ
hjic-110	21	11	rate	rate	NOUN
hjic-110	21	12	and	and	CCONJ
hjic-110	21	13	solubility	solubility	NOUN
hjic-110	21	14	of	of	ADP
hjic-110	21	15	poorly	poorly	ADV
hjic-110	21	16	water	water	NOUN
hjic-110	21	17	-	-	PUNCT
hjic-110	21	18	soluble	soluble	ADJ
hjic-110	21	19	apis	apis	NOUN
hjic-110	21	20	.	.	PUNCT
hjic-110	22	1	cyclodextrines	cyclodextrine	NOUN
hjic-110	22	2	were	be	AUX
hjic-110	22	3	successfully	successfully	ADV
hjic-110	22	4	used	use	VERB
hjic-110	22	5	to	to	PART
hjic-110	22	6	form	form	VERB
hjic-110	22	7	inclusion	inclusion	NOUN
hjic-110	22	8	complexes	complex	NOUN
hjic-110	22	9	with	with	ADP
hjic-110	22	10	drug	drug	NOUN
hjic-110	22	11	molecules	molecule	NOUN
hjic-110	22	12	of	of	ADP
hjic-110	22	13	appropriate	appropriate	ADJ
hjic-110	22	14	size	size	NOUN
hjic-110	22	15	[	[	X
hjic-110	22	16	4	4	NUM
hjic-110	22	17	-	-	SYM
hjic-110	22	18	6	6	NUM
hjic-110	22	19	]	]	PUNCT
hjic-110	22	20	.	.	PUNCT
hjic-110	23	1	beside	beside	ADP
hjic-110	23	2	cyclodextrins	cyclodextrin	NOUN
hjic-110	23	3	non	non	ADJ
hjic-110	23	4	-	-	ADJ
hjic-110	23	5	ionic	ionic	ADJ
hjic-110	23	6	surfactants	surfactant	NOUN
hjic-110	23	7	are	be	AUX
hjic-110	23	8	also	also	ADV
hjic-110	23	9	widely	widely	ADV
hjic-110	23	10	used	use	VERB
hjic-110	23	11	foremost	foremost	ADV
hjic-110	23	12	in	in	ADP
hjic-110	23	13	the	the	DET
hjic-110	23	14	precipitation	precipitation	NOUN
hjic-110	23	15	of	of	ADP
hjic-110	23	16	surface	surface	NOUN
hjic-110	23	17	-	-	PUNCT
hjic-110	23	18	modified	modify	VERB
hjic-110	23	19	drug	drug	NOUN
hjic-110	23	20	-	-	PUNCT
hjic-110	23	21	carrier	carrier	NOUN
hjic-110	23	22	systems	system	NOUN
hjic-110	23	23	[	[	X
hjic-110	23	24	7,8	7,8	NUM
hjic-110	23	25	]	]	PUNCT
hjic-110	23	26	,	,	PUNCT
hjic-110	23	27	solid	solid	ADJ
hjic-110	23	28	solutions	solution	NOUN
hjic-110	23	29	and	and	CCONJ
hjic-110	23	30	solid	solid	ADJ
hjic-110	23	31	dispersions[9	dispersions[9	NOUN
hjic-110	23	32	]	]	PUNCT
hjic-110	23	33	.	.	PUNCT
hjic-110	24	1	in	in	ADP
hjic-110	24	2	solid	solid	ADJ
hjic-110	24	3	solutions	solution	NOUN
hjic-110	24	4	and	and	CCONJ
hjic-110	24	5	solid	solid	ADJ
hjic-110	24	6	dispersions	dispersion	NOUN
hjic-110	24	7	drug	drug	NOUN
hjic-110	24	8	molecules	molecule	NOUN
hjic-110	24	9	or	or	CCONJ
hjic-110	24	10	very	very	ADV
hjic-110	24	11	fine	fine	ADJ
hjic-110	24	12	drug	drug	NOUN
hjic-110	24	13	crystals	crystal	NOUN
hjic-110	24	14	are	be	AUX
hjic-110	24	15	dispersed	disperse	VERB
hjic-110	24	16	in	in	ADP
hjic-110	24	17	a	a	DET
hjic-110	24	18	biologically	biologically	ADV
hjic-110	24	19	inert	inert	ADJ
hjic-110	24	20	and	and	CCONJ
hjic-110	24	21	biocompatible	biocompatible	ADJ
hjic-110	24	22	matrix	matrix	NOUN
hjic-110	24	23	.	.	PUNCT
hjic-110	25	1	the	the	DET
hjic-110	25	2	therapeutic	therapeutic	ADJ
hjic-110	25	3	use	use	NOUN
hjic-110	25	4	of	of	ADP
hjic-110	25	5	solid	solid	ADJ
hjic-110	25	6	dispersions	dispersion	NOUN
hjic-110	25	7	has	have	AUX
hjic-110	25	8	been	be	AUX
hjic-110	25	9	the	the	DET
hjic-110	25	10	focus	focus	NOUN
hjic-110	25	11	of	of	ADP
hjic-110	25	12	many	many	ADJ
hjic-110	25	13	recent	recent	ADJ
hjic-110	25	14	studies	study	NOUN
hjic-110	25	15	[	[	X
hjic-110	25	16	9	9	NUM
hjic-110	25	17	-	-	SYM
hjic-110	25	18	12	12	NUM
hjic-110	25	19	]	]	PUNCT
hjic-110	25	20	.	.	PUNCT
hjic-110	26	1	although	although	SCONJ
hjic-110	26	2	,	,	PUNCT
hjic-110	26	3	the	the	DET
hjic-110	26	4	medical	medical	ADJ
hjic-110	26	5	benefits	benefit	NOUN
hjic-110	26	6	associated	associate	VERB
hjic-110	26	7	with	with	ADP
hjic-110	26	8	solid	solid	ADJ
hjic-110	26	9	dispersions	dispersion	NOUN
hjic-110	26	10	are	be	AUX
hjic-110	26	11	known	know	VERB
hjic-110	26	12	for	for	ADP
hjic-110	26	13	long	long	ADJ
hjic-110	26	14	time	time	NOUN
hjic-110	26	15	,	,	PUNCT
hjic-110	26	16	they	they	PRON
hjic-110	26	17	are	be	AUX
hjic-110	26	18	not	not	PART
hjic-110	26	19	widely	widely	ADV
hjic-110	26	20	used	use	VERB
hjic-110	26	21	because	because	SCONJ
hjic-110	26	22	of	of	ADP
hjic-110	26	23	the	the	DET
hjic-110	26	24	manufacturing	manufacturing	NOUN
hjic-110	26	25	difficulties	difficulty	NOUN
hjic-110	26	26	encountered	encounter	VERB
hjic-110	26	27	with	with	ADP
hjic-110	26	28	conventional	conventional	ADJ
hjic-110	26	29	techniques	technique	NOUN
hjic-110	26	30	.	.	PUNCT
hjic-110	27	1	spray	spray	NOUN
hjic-110	27	2	-	-	PUNCT
hjic-110	27	3	drying	drying	NOUN
hjic-110	27	4	was	be	AUX
hjic-110	27	5	proved	prove	VERB
hjic-110	27	6	to	to	PART
hjic-110	27	7	be	be	AUX
hjic-110	27	8	efficient	efficient	ADJ
hjic-110	27	9	in	in	ADP
hjic-110	27	10	the	the	DET
hjic-110	27	11	preparation	preparation	NOUN
hjic-110	27	12	of	of	ADP
hjic-110	27	13	micrometer	micrometer	NOUN
hjic-110	27	14	sized	size	VERB
hjic-110	27	15	solid	solid	ADJ
hjic-110	27	16	solution	solution	NOUN
hjic-110	27	17	powders	powder	NOUN
hjic-110	27	18	but	but	CCONJ
hjic-110	27	19	particle	particle	NOUN
hjic-110	27	20	collection	collection	NOUN
hjic-110	27	21	is	be	AUX
hjic-110	27	22	still	still	ADV
hjic-110	27	23	a	a	DET
hjic-110	27	24	challenging	challenging	ADJ
hjic-110	27	25	task	task	NOUN
hjic-110	28	1	[	[	X
hjic-110	28	2	13	13	NUM
hjic-110	28	3	]	]	PUNCT
hjic-110	28	4	.	.	PUNCT
hjic-110	29	1	formulations	formulation	NOUN
hjic-110	29	2	prepared	prepare	VERB
hjic-110	29	3	by	by	ADP
hjic-110	29	4	solvent	solvent	ADJ
hjic-110	29	5	evaporation	evaporation	NOUN
hjic-110	29	6	and	and	CCONJ
hjic-110	29	7	hot	hot	ADJ
hjic-110	29	8	melt	melt	NOUN
hjic-110	29	9	method	method	NOUN
hjic-110	29	10	may	may	AUX
hjic-110	29	11	contain	contain	VERB
hjic-110	29	12	impurities	impurity	NOUN
hjic-110	29	13	coming	come	VERB
hjic-110	29	14	from	from	ADP
hjic-110	29	15	solvent	solvent	NOUN
hjic-110	29	16	residues	residue	NOUN
hjic-110	29	17	or	or	CCONJ
hjic-110	29	18	thermal	thermal	ADJ
hjic-110	29	19	decomposition	decomposition	NOUN
hjic-110	29	20	of	of	ADP
hjic-110	29	21	the	the	DET
hjic-110	29	22	api	api	NOUN
hjic-110	29	23	.	.	PUNCT
hjic-110	30	1	additionally	additionally	ADV
hjic-110	30	2	,	,	PUNCT
hjic-110	30	3	if	if	SCONJ
hjic-110	30	4	the	the	DET
hjic-110	30	5	active	active	ADJ
hjic-110	30	6	substance	substance	NOUN
hjic-110	30	7	exists	exist	VERB
hjic-110	30	8	in	in	ADP
hjic-110	30	9	several	several	ADJ
hjic-110	30	10	polymorphic	polymorphic	ADJ
hjic-110	30	11	forms	form	NOUN
hjic-110	30	12	it	it	PRON
hjic-110	30	13	is	be	AUX
hjic-110	30	14	recommended	recommend	VERB
hjic-110	30	15	that	that	SCONJ
hjic-110	30	16	formulation	formulation	NOUN
hjic-110	30	17	contains	contain	VERB
hjic-110	30	18	the	the	DET
hjic-110	30	19	thermodynamically	thermodynamically	ADV
hjic-110	30	20	most	most	ADV
hjic-110	30	21	stable	stable	ADJ
hjic-110	30	22	form	form	NOUN
hjic-110	30	23	[	[	X
hjic-110	30	24	14	14	NUM
hjic-110	30	25	]	]	PUNCT
hjic-110	30	26	.	.	PUNCT
hjic-110	31	1	metastable	metastable	ADJ
hjic-110	31	2	forms	form	NOUN
hjic-110	31	3	may	may	AUX
hjic-110	31	4	convert	convert	VERB
hjic-110	31	5	to	to	ADP
hjic-110	31	6	a	a	DET
hjic-110	31	7	more	more	ADV
hjic-110	31	8	stable	stable	ADJ
hjic-110	31	9	one	one	NUM
hjic-110	31	10	which	which	PRON
hjic-110	31	11	in	in	ADP
hjic-110	31	12	turn	turn	NOUN
hjic-110	31	13	may	may	AUX
hjic-110	31	14	have	have	VERB
hjic-110	31	15	different	different	ADJ
hjic-110	31	16	bioavailability	bioavailability	NOUN
hjic-110	31	17	or	or	CCONJ
hjic-110	31	18	,	,	PUNCT
hjic-110	31	19	in	in	ADP
hjic-110	31	20	extreme	extreme	ADJ
hjic-110	31	21	cases	case	NOUN
hjic-110	31	22	,	,	PUNCT
hjic-110	31	23	catastrophic	catastrophic	ADJ
hjic-110	31	24	health	health	NOUN
hjic-110	31	25	effects	effect	NOUN
hjic-110	31	26	[	[	X
hjic-110	31	27	15	15	NUM
hjic-110	31	28	]	]	PUNCT
hjic-110	31	29	.	.	PUNCT
hjic-110	32	1	however	however	ADV
hjic-110	32	2	,	,	PUNCT
hjic-110	32	3	most	most	ADJ
hjic-110	32	4	of	of	ADP
hjic-110	32	5	these	these	DET
hjic-110	32	6	drug	drug	NOUN
hjic-110	32	7	-	-	PUNCT
hjic-110	32	8	carrier	carrier	NOUN
hjic-110	32	9	systems	system	NOUN
hjic-110	32	10	contain	contain	VERB
hjic-110	32	11	the	the	DET
hjic-110	32	12	active	active	ADJ
hjic-110	32	13	substance	substance	NOUN
hjic-110	32	14	in	in	ADP
hjic-110	32	15	amorphous	amorphous	ADJ
hjic-110	32	16	form	form	NOUN
hjic-110	32	17	which	which	PRON
hjic-110	32	18	is	be	AUX
hjic-110	32	19	known	know	VERB
hjic-110	32	20	to	to	PART
hjic-110	32	21	be	be	AUX
hjic-110	32	22	thermodynamically	thermodynamically	ADV
hjic-110	32	23	42	42	NUM
hjic-110	32	24	unstable	unstable	ADJ
hjic-110	32	25	with	with	ADP
hjic-110	32	26	respect	respect	NOUN
hjic-110	32	27	to	to	ADP
hjic-110	32	28	its	its	PRON
hjic-110	32	29	crystalline	crystalline	ADJ
hjic-110	32	30	counterpart	counterpart	NOUN
hjic-110	32	31	above	above	ADP
hjic-110	32	32	the	the	DET
hjic-110	32	33	glass	glass	NOUN
hjic-110	32	34	transition	transition	NOUN
hjic-110	32	35	temperature	temperature	NOUN
hjic-110	32	36	.	.	PUNCT
hjic-110	33	1	although	although	SCONJ
hjic-110	33	2	,	,	PUNCT
hjic-110	33	3	pharmaceutical	pharmaceutical	ADJ
hjic-110	33	4	products	product	NOUN
hjic-110	33	5	are	be	AUX
hjic-110	33	6	supposed	suppose	VERB
hjic-110	33	7	to	to	PART
hjic-110	33	8	contain	contain	VERB
hjic-110	33	9	only	only	ADV
hjic-110	33	10	the	the	DET
hjic-110	33	11	most	most	ADV
hjic-110	33	12	stable	stable	ADJ
hjic-110	33	13	polymorph	polymorph	NOUN
hjic-110	33	14	,	,	PUNCT
hjic-110	33	15	the	the	DET
hjic-110	33	16	use	use	NOUN
hjic-110	33	17	of	of	ADP
hjic-110	33	18	stabilized	stabilize	VERB
hjic-110	33	19	amorphous	amorphous	ADJ
hjic-110	33	20	form	form	NOUN
hjic-110	33	21	can	can	AUX
hjic-110	33	22	be	be	AUX
hjic-110	33	23	justified	justify	VERB
hjic-110	33	24	by	by	ADP
hjic-110	33	25	medical	medical	ADJ
hjic-110	33	26	benefits	benefit	NOUN
hjic-110	33	27	if	if	SCONJ
hjic-110	33	28	there	there	PRON
hjic-110	33	29	is	be	VERB
hjic-110	33	30	no	no	DET
hjic-110	33	31	provable	provable	ADJ
hjic-110	33	32	risk	risk	NOUN
hjic-110	33	33	to	to	ADP
hjic-110	33	34	the	the	DET
hjic-110	33	35	patient	patient	NOUN
hjic-110	34	1	[	[	X
hjic-110	34	2	14	14	NUM
hjic-110	34	3	]	]	PUNCT
hjic-110	34	4	.	.	PUNCT
hjic-110	35	1	several	several	ADJ
hjic-110	35	2	medical	medical	ADJ
hjic-110	35	3	benefits	benefit	NOUN
hjic-110	35	4	have	have	AUX
hjic-110	35	5	been	be	AUX
hjic-110	35	6	reported	report	VERB
hjic-110	35	7	in	in	ADP
hjic-110	35	8	the	the	DET
hjic-110	35	9	literature	literature	NOUN
hjic-110	35	10	including	include	VERB
hjic-110	35	11	better	well	ADJ
hjic-110	35	12	wettability	wettability	NOUN
hjic-110	35	13	,	,	PUNCT
hjic-110	35	14	enhanced	enhance	VERB
hjic-110	35	15	dissolution	dissolution	NOUN
hjic-110	35	16	rate	rate	NOUN
hjic-110	35	17	and	and	CCONJ
hjic-110	35	18	solubility	solubility	NOUN
hjic-110	35	19	[	[	X
hjic-110	35	20	10,11,16	10,11,16	NUM
hjic-110	35	21	]	]	PUNCT
hjic-110	35	22	.	.	PUNCT
hjic-110	36	1	however	however	ADV
hjic-110	36	2	,	,	PUNCT
hjic-110	36	3	conventional	conventional	ADJ
hjic-110	36	4	methods	method	NOUN
hjic-110	36	5	i.e.	i.e.	X
hjic-110	36	6	spray	spray	NOUN
hjic-110	36	7	-	-	PUNCT
hjic-110	36	8	drying	dry	VERB
hjic-110	36	9	,	,	PUNCT
hjic-110	36	10	solvent	solvent	ADJ
hjic-110	36	11	evaporation	evaporation	NOUN
hjic-110	36	12	and	and	CCONJ
hjic-110	36	13	hot	hot	ADJ
hjic-110	36	14	melt	melt	NOUN
hjic-110	36	15	method	method	NOUN
hjic-110	36	16	are	be	AUX
hjic-110	36	17	known	know	VERB
hjic-110	36	18	to	to	PART
hjic-110	36	19	have	have	VERB
hjic-110	36	20	inherent	inherent	ADJ
hjic-110	36	21	limitations	limitation	NOUN
hjic-110	36	22	,	,	PUNCT
hjic-110	36	23	like	like	ADP
hjic-110	36	24	poor	poor	ADJ
hjic-110	36	25	particle	particle	NOUN
hjic-110	36	26	recovery	recovery	NOUN
hjic-110	36	27	yield	yield	NOUN
hjic-110	36	28	,	,	PUNCT
hjic-110	36	29	high	high	ADJ
hjic-110	36	30	residual	residual	ADJ
hjic-110	36	31	solvent	solvent	NOUN
hjic-110	36	32	content	content	NOUN
hjic-110	36	33	or	or	CCONJ
hjic-110	36	34	thermal	thermal	ADJ
hjic-110	36	35	degradation	degradation	NOUN
hjic-110	36	36	of	of	ADP
hjic-110	36	37	the	the	DET
hjic-110	36	38	api	api	NOUN
hjic-110	36	39	.	.	PUNCT
hjic-110	37	1	residual	residual	ADJ
hjic-110	37	2	solvent	solvent	NOUN
hjic-110	37	3	traces	trace	NOUN
hjic-110	37	4	and	and	CCONJ
hjic-110	37	5	degradation	degradation	NOUN
hjic-110	37	6	products	product	NOUN
hjic-110	37	7	might	might	AUX
hjic-110	37	8	be	be	AUX
hjic-110	37	9	highly	highly	ADV
hjic-110	37	10	toxic	toxic	ADJ
hjic-110	37	11	to	to	ADP
hjic-110	37	12	the	the	DET
hjic-110	37	13	patient	patient	NOUN
hjic-110	37	14	and	and	CCONJ
hjic-110	37	15	should	should	AUX
hjic-110	37	16	comply	comply	VERB
hjic-110	37	17	with	with	ADP
hjic-110	37	18	very	very	ADV
hjic-110	37	19	low	low	ADJ
hjic-110	37	20	recommended	recommend	VERB
hjic-110	37	21	levels	level	NOUN
hjic-110	37	22	.	.	PUNCT
hjic-110	38	1	in	in	ADP
hjic-110	38	2	spite	spite	NOUN
hjic-110	38	3	of	of	ADP
hjic-110	38	4	the	the	DET
hjic-110	38	5	tendency	tendency	NOUN
hjic-110	38	6	to	to	PART
hjic-110	38	7	replace	replace	VERB
hjic-110	38	8	toxic	toxic	ADJ
hjic-110	38	9	solvents	solvent	NOUN
hjic-110	38	10	or	or	CCONJ
hjic-110	38	11	limit	limit	VERB
hjic-110	38	12	their	their	PRON
hjic-110	38	13	application	application	NOUN
hjic-110	38	14	in	in	ADP
hjic-110	38	15	the	the	DET
hjic-110	38	16	pharmaceutical	pharmaceutical	NOUN
hjic-110	38	17	industry	industry	NOUN
hjic-110	38	18	these	these	DET
hjic-110	38	19	solvents	solvent	NOUN
hjic-110	38	20	are	be	AUX
hjic-110	38	21	not	not	PART
hjic-110	38	22	always	always	ADV
hjic-110	38	23	avoidable	avoidable	ADJ
hjic-110	38	24	.	.	PUNCT
hjic-110	39	1	fig	fig	NOUN
hjic-110	39	2	.	.	PUNCT
hjic-110	40	1	1	1	X
hjic-110	40	2	.	.	X
hjic-110	40	3	the	the	DET
hjic-110	40	4	chemical	chemical	ADJ
hjic-110	40	5	structure	structure	NOUN
hjic-110	40	6	of	of	ADP
hjic-110	40	7	oxeglitazar	oxeglitazar	NOUN
hjic-110	40	8	.	.	PUNCT
hjic-110	41	1	in	in	ADP
hjic-110	41	2	the	the	DET
hjic-110	41	3	late	late	ADJ
hjic-110	41	4	80	80	NUM
hjic-110	41	5	’s	’s	ADJ
hjic-110	41	6	,	,	PUNCT
hjic-110	41	7	supercritical	supercritical	ADJ
hjic-110	41	8	fluid	fluid	NOUN
hjic-110	41	9	(	(	PUNCT
hjic-110	41	10	scf	scf	PROPN
hjic-110	41	11	)	)	PUNCT
hjic-110	41	12	processes	process	NOUN
hjic-110	41	13	appeared	appear	VERB
hjic-110	41	14	in	in	ADP
hjic-110	41	15	drug	drug	NOUN
hjic-110	41	16	formulation	formulation	NOUN
hjic-110	41	17	as	as	ADP
hjic-110	41	18	an	an	DET
hjic-110	41	19	alternative	alternative	NOUN
hjic-110	41	20	to	to	ADP
hjic-110	41	21	conventional	conventional	ADJ
hjic-110	41	22	processes	process	NOUN
hjic-110	41	23	[	[	X
hjic-110	41	24	17	17	NUM
hjic-110	41	25	-	-	SYM
hjic-110	41	26	21	21	NUM
hjic-110	41	27	]	]	PUNCT
hjic-110	41	28	.	.	PUNCT
hjic-110	42	1	the	the	DET
hjic-110	42	2	most	most	ADV
hjic-110	42	3	common	common	ADJ
hjic-110	42	4	scf	scf	PROPN
hjic-110	42	5	is	be	AUX
hjic-110	42	6	carbon	carbon	NOUN
hjic-110	42	7	dioxide	dioxide	NOUN
hjic-110	42	8	(	(	PUNCT
hjic-110	42	9	scco2	scco2	PROPN
hjic-110	42	10	)	)	PUNCT
hjic-110	42	11	which	which	PRON
hjic-110	42	12	is	be	AUX
hjic-110	42	13	non	non	X
hjic-110	42	14	toxic	toxic	ADJ
hjic-110	42	15	,	,	PUNCT
hjic-110	42	16	non	non	X
hjic-110	42	17	flammable	flammable	ADJ
hjic-110	42	18	,	,	PUNCT
hjic-110	42	19	cost	cost	VERB
hjic-110	42	20	efficient	efficient	ADJ
hjic-110	42	21	and	and	CCONJ
hjic-110	42	22	available	available	ADJ
hjic-110	42	23	in	in	ADP
hjic-110	42	24	large	large	ADJ
hjic-110	42	25	quantities	quantity	NOUN
hjic-110	42	26	.	.	PUNCT
hjic-110	43	1	owing	owe	VERB
hjic-110	43	2	to	to	ADP
hjic-110	43	3	its	its	PRON
hjic-110	43	4	mild	mild	ADJ
hjic-110	43	5	critical	critical	ADJ
hjic-110	43	6	temperature	temperature	NOUN
hjic-110	43	7	(	(	PUNCT
hjic-110	43	8	31.06	31.06	NUM
hjic-110	43	9	°	°	SYM
hjic-110	43	10	c	c	NOUN
hjic-110	43	11	)	)	PUNCT
hjic-110	43	12	and	and	CCONJ
hjic-110	43	13	critical	critical	ADJ
hjic-110	43	14	pressure	pressure	NOUN
hjic-110	43	15	(	(	PUNCT
hjic-110	43	16	73.8	73.8	NUM
hjic-110	43	17	bar	bar	NOUN
hjic-110	43	18	)	)	PUNCT
hjic-110	43	19	,	,	PUNCT
hjic-110	43	20	co2	co2	NOUN
hjic-110	43	21	is	be	AUX
hjic-110	43	22	suitable	suitable	ADJ
hjic-110	43	23	to	to	AUX
hjic-110	43	24	precipitate	precipitate	VERB
hjic-110	43	25	heat	heat	NOUN
hjic-110	43	26	-	-	PUNCT
hjic-110	43	27	sensitive	sensitive	ADJ
hjic-110	43	28	apis	apis	PROPN
hjic-110	43	29	.	.	PUNCT
hjic-110	44	1	additionally	additionally	ADV
hjic-110	44	2	,	,	PUNCT
hjic-110	44	3	these	these	DET
hjic-110	44	4	techniques	technique	NOUN
hjic-110	44	5	were	be	AUX
hjic-110	44	6	proved	prove	VERB
hjic-110	44	7	to	to	PART
hjic-110	44	8	reduce	reduce	VERB
hjic-110	44	9	particle	particle	NOUN
hjic-110	44	10	size	size	NOUN
hjic-110	44	11	and	and	CCONJ
hjic-110	44	12	residual	residual	ADJ
hjic-110	44	13	solvent	solvent	NOUN
hjic-110	44	14	content	content	NOUN
hjic-110	44	15	in	in	ADP
hjic-110	44	16	one	one	NUM
hjic-110	44	17	step	step	NOUN
hjic-110	44	18	and	and	CCONJ
hjic-110	44	19	,	,	PUNCT
hjic-110	44	20	in	in	ADP
hjic-110	44	21	some	some	DET
hjic-110	44	22	cases	case	NOUN
hjic-110	44	23	,	,	PUNCT
hjic-110	44	24	crystal	crystal	NOUN
hjic-110	44	25	habit	habit	NOUN
hjic-110	44	26	,	,	PUNCT
hjic-110	44	27	morphology	morphology	NOUN
hjic-110	44	28	and	and	CCONJ
hjic-110	44	29	polymorphic	polymorphic	ADJ
hjic-110	44	30	form	form	NOUN
hjic-110	44	31	of	of	ADP
hjic-110	44	32	the	the	DET
hjic-110	44	33	processed	process	VERB
hjic-110	44	34	drug	drug	NOUN
hjic-110	44	35	could	could	AUX
hjic-110	44	36	be	be	AUX
hjic-110	44	37	controlled	control	VERB
hjic-110	44	38	as	as	ADV
hjic-110	44	39	well	well	ADV
hjic-110	44	40	[	[	X
hjic-110	44	41	21	21	NUM
hjic-110	44	42	-	-	SYM
hjic-110	44	43	26	26	NUM
hjic-110	44	44	]	]	PUNCT
hjic-110	44	45	.	.	PUNCT
hjic-110	45	1	unlike	unlike	ADP
hjic-110	45	2	liquid	liquid	ADJ
hjic-110	45	3	solvents	solvent	NOUN
hjic-110	45	4	,	,	PUNCT
hjic-110	45	5	scco2	scco2	NOUN
hjic-110	45	6	is	be	AUX
hjic-110	45	7	easy	easy	ADJ
hjic-110	45	8	to	to	PART
hjic-110	45	9	separate	separate	VERB
hjic-110	45	10	from	from	ADP
hjic-110	45	11	solid	solid	ADJ
hjic-110	45	12	products	product	NOUN
hjic-110	45	13	and	and	CCONJ
hjic-110	45	14	it	it	PRON
hjic-110	45	15	causes	cause	VERB
hjic-110	45	16	no	no	DET
hjic-110	45	17	adverse	adverse	ADJ
hjic-110	45	18	health	health	NOUN
hjic-110	45	19	effect	effect	NOUN
hjic-110	45	20	.	.	PUNCT
hjic-110	46	1	furthermore	furthermore	ADV
hjic-110	46	2	,	,	PUNCT
hjic-110	46	3	if	if	SCONJ
hjic-110	46	4	the	the	DET
hjic-110	46	5	scf	scf	PROPN
hjic-110	46	6	plays	play	VERB
hjic-110	46	7	the	the	DET
hjic-110	46	8	role	role	NOUN
hjic-110	46	9	of	of	ADP
hjic-110	46	10	antisolvent	antisolvent	NOUN
hjic-110	46	11	,	,	PUNCT
hjic-110	46	12	residual	residual	ADJ
hjic-110	46	13	solvent	solvent	NOUN
hjic-110	46	14	traces	trace	NOUN
hjic-110	46	15	can	can	AUX
hjic-110	46	16	be	be	AUX
hjic-110	46	17	efficiently	efficiently	ADV
hjic-110	46	18	removed	remove	VERB
hjic-110	46	19	with	with	ADP
hjic-110	46	20	scf	scf	PROPN
hjic-110	46	21	extraction	extraction	NOUN
hjic-110	46	22	[	[	X
hjic-110	46	23	22,27	22,27	NOUN
hjic-110	46	24	]	]	PUNCT
hjic-110	46	25	.	.	PUNCT
hjic-110	47	1	more	more	ADJ
hjic-110	47	2	than	than	ADP
hjic-110	47	3	ten	ten	NUM
hjic-110	47	4	different	different	ADJ
hjic-110	47	5	techniques	technique	NOUN
hjic-110	47	6	were	be	AUX
hjic-110	47	7	published	publish	VERB
hjic-110	47	8	and/or	and/or	CCONJ
hjic-110	47	9	patented	patent	VERB
hjic-110	47	10	in	in	ADP
hjic-110	47	11	the	the	DET
hjic-110	47	12	field	field	NOUN
hjic-110	47	13	of	of	ADP
hjic-110	47	14	particle	particle	NOUN
hjic-110	47	15	formation	formation	NOUN
hjic-110	47	16	using	use	VERB
hjic-110	47	17	scfs	scfs	NOUN
hjic-110	47	18	.	.	PUNCT
hjic-110	48	1	the	the	DET
hjic-110	48	2	most	most	ADV
hjic-110	48	3	important	important	ADJ
hjic-110	48	4	are	be	AUX
hjic-110	48	5	:	:	PUNCT
hjic-110	48	6	rapid	rapid	ADJ
hjic-110	48	7	expansion	expansion	NOUN
hjic-110	48	8	from	from	ADP
hjic-110	48	9	supercritical	supercritical	ADJ
hjic-110	48	10	solution	solution	NOUN
hjic-110	48	11	(	(	PUNCT
hjic-110	48	12	ress	ress	NOUN
hjic-110	48	13	)	)	PUNCT
hjic-110	49	1	[	[	X
hjic-110	49	2	11,28	11,28	NUM
hjic-110	49	3	]	]	X
hjic-110	49	4	;	;	PUNCT
hjic-110	49	5	gas	gas	NOUN
hjic-110	49	6	antisolvent	antisolvent	NOUN
hjic-110	49	7	(	(	PUNCT
hjic-110	49	8	gas	gas	NOUN
hjic-110	49	9	)	)	PUNCT
hjic-110	50	1	[	[	X
hjic-110	50	2	11,29	11,29	NUM
hjic-110	50	3	-	-	SYM
hjic-110	50	4	31	31	NUM
hjic-110	50	5	]	]	PUNCT
hjic-110	50	6	,	,	PUNCT
hjic-110	50	7	supercritical	supercritical	ADJ
hjic-110	50	8	antisolvent	antisolvent	NOUN
hjic-110	50	9	(	(	PUNCT
hjic-110	50	10	sas	sas	PROPN
hjic-110	50	11	)	)	PUNCT
hjic-110	51	1	[	[	X
hjic-110	51	2	28,32	28,32	NUM
hjic-110	51	3	-	-	SYM
hjic-110	51	4	36	36	NUM
hjic-110	51	5	]	]	PUNCT
hjic-110	51	6	,	,	PUNCT
hjic-110	51	7	aerosol	aerosol	VERB
hjic-110	51	8	solvent	solvent	NOUN
hjic-110	51	9	extraction	extraction	NOUN
hjic-110	51	10	sysytem	sysytem	NOUN
hjic-110	51	11	(	(	PUNCT
hjic-110	51	12	ases	ases	PROPN
hjic-110	51	13	)	)	PUNCT
hjic-110	52	1	[	[	X
hjic-110	52	2	13,22	13,22	NUM
hjic-110	52	3	]	]	PUNCT
hjic-110	52	4	,	,	PUNCT
hjic-110	52	5	solution	solution	NOUN
hjic-110	52	6	enhanced	enhance	VERB
hjic-110	52	7	dispersion	dispersion	NOUN
hjic-110	52	8	by	by	ADP
hjic-110	52	9	supercritical	supercritical	ADJ
hjic-110	52	10	fluids	fluid	NOUN
hjic-110	52	11	(	(	PUNCT
hjic-110	52	12	seds	sed	NOUN
hjic-110	52	13	)	)	PUNCT
hjic-110	53	1	[	[	X
hjic-110	53	2	16,37,38	16,37,38	NUM
hjic-110	53	3	]	]	PUNCT
hjic-110	53	4	and	and	CCONJ
hjic-110	53	5	particles	particle	NOUN
hjic-110	53	6	from	from	ADP
hjic-110	53	7	gassaturated	gassaturate	VERB
hjic-110	53	8	solution	solution	NOUN
hjic-110	53	9	(	(	PUNCT
hjic-110	53	10	pgss	pgss	ADV
hjic-110	53	11	)	)	PUNCT
hjic-110	54	1	[	[	X
hjic-110	54	2	39	39	NUM
hjic-110	54	3	]	]	PUNCT
hjic-110	54	4	.	.	PUNCT
hjic-110	55	1	in	in	ADP
hjic-110	55	2	this	this	DET
hjic-110	55	3	study	study	NOUN
hjic-110	55	4	,	,	PUNCT
hjic-110	55	5	supercritical	supercritical	ADJ
hjic-110	55	6	antisolvent	antisolvent	NOUN
hjic-110	55	7	and	and	CCONJ
hjic-110	55	8	conventional	conventional	ADJ
hjic-110	55	9	coevaporation	coevaporation	NOUN
hjic-110	55	10	was	be	AUX
hjic-110	55	11	compared	compare	VERB
hjic-110	55	12	using	use	VERB
hjic-110	55	13	pvp	pvp	PROPN
hjic-110	55	14	k17	k17	PROPN
hjic-110	55	15	and	and	CCONJ
hjic-110	55	16	poloxamer	poloxamer	PROPN
hjic-110	55	17	407	407	NUM
hjic-110	55	18	as	as	ADP
hjic-110	55	19	excipient	excipient	ADJ
hjic-110	55	20	and	and	CCONJ
hjic-110	55	21	oxeglitazar	oxeglitazar	NOUN
hjic-110	55	22	as	as	ADP
hjic-110	55	23	model	model	NOUN
hjic-110	55	24	drug	drug	NOUN
hjic-110	55	25	.	.	PUNCT
hjic-110	56	1	oxeglitazar	oxeglitazar	NOUN
hjic-110	56	2	is	be	AUX
hjic-110	56	3	one	one	NUM
hjic-110	56	4	of	of	ADP
hjic-110	56	5	the	the	DET
hjic-110	56	6	newly	newly	ADV
hjic-110	56	7	developed	develop	VERB
hjic-110	56	8	dual	dual	ADJ
hjic-110	56	9	ppar	ppar	NOUN
hjic-110	56	10	alpha	alpha	PROPN
hjic-110	56	11	/	/	SYM
hjic-110	56	12	gamma	gamma	NOUN
hjic-110	56	13	agonists	agonist	NOUN
hjic-110	56	14	,	,	PUNCT
hjic-110	56	15	of	of	ADP
hjic-110	56	16	which	which	PRON
hjic-110	56	17	the	the	DET
hjic-110	56	18	oral	oral	ADJ
hjic-110	56	19	bioavailability	bioavailability	NOUN
hjic-110	56	20	is	be	AUX
hjic-110	56	21	limited	limit	VERB
hjic-110	56	22	by	by	ADP
hjic-110	56	23	its	its	PRON
hjic-110	56	24	low	low	ADJ
hjic-110	56	25	aqueous	aqueous	ADJ
hjic-110	56	26	solubility	solubility	NOUN
hjic-110	56	27	.	.	PUNCT
hjic-110	57	1	in	in	ADP
hjic-110	57	2	addition	addition	NOUN
hjic-110	57	3	to	to	ADP
hjic-110	57	4	potentially	potentially	ADV
hjic-110	57	5	low	low	ADJ
hjic-110	57	6	absorption	absorption	NOUN
hjic-110	57	7	in	in	ADP
hjic-110	57	8	patients	patient	NOUN
hjic-110	57	9	,	,	PUNCT
hjic-110	57	10	conventionally	conventionally	ADV
hjic-110	57	11	crystallized	crystallize	VERB
hjic-110	57	12	oxeglitazar	oxeglitazar	NOUN
hjic-110	57	13	is	be	AUX
hjic-110	57	14	difficult	difficult	ADJ
hjic-110	57	15	to	to	PART
hjic-110	57	16	handle	handle	VERB
hjic-110	57	17	because	because	SCONJ
hjic-110	57	18	of	of	ADP
hjic-110	57	19	its	its	PRON
hjic-110	57	20	needle	needle	NOUN
hjic-110	57	21	-	-	PUNCT
hjic-110	57	22	like	like	ADJ
hjic-110	57	23	habit	habit	NOUN
hjic-110	57	24	.	.	PUNCT
hjic-110	58	1	thus	thus	ADV
hjic-110	58	2	,	,	PUNCT
hjic-110	58	3	we	we	PRON
hjic-110	58	4	aimed	aim	VERB
hjic-110	58	5	to	to	PART
hjic-110	58	6	improve	improve	VERB
hjic-110	58	7	both	both	DET
hjic-110	58	8	bioavailability	bioavailability	NOUN
hjic-110	58	9	and	and	CCONJ
hjic-110	58	10	manufacturability	manufacturability	NOUN
hjic-110	58	11	of	of	ADP
hjic-110	58	12	the	the	DET
hjic-110	58	13	model	model	NOUN
hjic-110	58	14	drug	drug	NOUN
hjic-110	58	15	.	.	PUNCT
hjic-110	59	1	solid	solid	ADJ
hjic-110	59	2	dispersions	dispersion	NOUN
hjic-110	59	3	were	be	AUX
hjic-110	59	4	characterized	characterize	VERB
hjic-110	59	5	by	by	ADP
hjic-110	59	6	powder	powder	NOUN
hjic-110	59	7	x	x	NOUN
hjic-110	59	8	-	-	NOUN
hjic-110	59	9	ray	ray	NOUN
hjic-110	59	10	diffraction	diffraction	NOUN
hjic-110	59	11	(	(	PUNCT
hjic-110	59	12	xrd	xrd	NOUN
hjic-110	59	13	)	)	PUNCT
hjic-110	59	14	,	,	PUNCT
hjic-110	59	15	fourier	fourier	NOUN
hjic-110	59	16	transform	transform	VERB
hjic-110	59	17	infrared	infrared	ADJ
hjic-110	59	18	spectroscopy	spectroscopy	NOUN
hjic-110	59	19	(	(	PUNCT
hjic-110	59	20	ftir	ftir	PROPN
hjic-110	59	21	)	)	PUNCT
hjic-110	59	22	,	,	PUNCT
hjic-110	59	23	scanning	scan	VERB
hjic-110	59	24	electron	electron	NOUN
hjic-110	59	25	microscopy	microscopy	NOUN
hjic-110	59	26	(	(	PUNCT
hjic-110	59	27	sem	sem	NOUN
hjic-110	59	28	)	)	PUNCT
hjic-110	59	29	,	,	PUNCT
hjic-110	59	30	gas	gas	NOUN
hjic-110	59	31	chromatography	chromatography	NOUN
hjic-110	59	32	(	(	PUNCT
hjic-110	59	33	gc	gc	PROPN
hjic-110	59	34	)	)	PUNCT
hjic-110	59	35	,	,	PUNCT
hjic-110	59	36	uv	uv	NOUN
hjic-110	59	37	/	/	SYM
hjic-110	59	38	vis	vis	X
hjic-110	59	39	spectroscopy	spectroscopy	NOUN
hjic-110	59	40	and	and	CCONJ
hjic-110	59	41	in	in	ADP
hjic-110	59	42	vitro	vitro	X
hjic-110	59	43	dissolution	dissolution	NOUN
hjic-110	59	44	tests	test	NOUN
hjic-110	59	45	.	.	PUNCT
hjic-110	60	1	experimental	experimental	ADJ
hjic-110	60	2	oxeglitazar	oxeglitazar	NOUN
hjic-110	60	3	was	be	AUX
hjic-110	60	4	obtained	obtain	VERB
hjic-110	60	5	from	from	ADP
hjic-110	60	6	merck	merck	PROPN
hjic-110	60	7	santé	santé	PROPN
hjic-110	60	8	,	,	PUNCT
hjic-110	60	9	france	france	PROPN
hjic-110	60	10	;	;	PUNCT
hjic-110	60	11	carbon	carbon	NOUN
hjic-110	60	12	dioxide	dioxide	NOUN
hjic-110	60	13	(	(	PUNCT
hjic-110	60	14	99.7	99.7	NUM
hjic-110	60	15	%	%	NOUN
hjic-110	60	16	)	)	PUNCT
hjic-110	60	17	was	be	AUX
hjic-110	60	18	supplied	supply	VERB
hjic-110	60	19	by	by	ADP
hjic-110	60	20	air	air	NOUN
hjic-110	60	21	liquide	liquide	PROPN
hjic-110	60	22	,	,	PUNCT
hjic-110	60	23	france	france	NOUN
hjic-110	60	24	;	;	PUNCT
hjic-110	60	25	ethanol	ethanol	NOUN
hjic-110	60	26	(	(	PUNCT
hjic-110	60	27	99.8	99.8	NUM
hjic-110	60	28	%	%	NOUN
hjic-110	60	29	)	)	PUNCT
hjic-110	60	30	was	be	AUX
hjic-110	60	31	purchased	purchase	VERB
hjic-110	60	32	from	from	ADP
hjic-110	60	33	carlo	carlo	PROPN
hjic-110	60	34	erba	erba	PROPN
hjic-110	60	35	,	,	PUNCT
hjic-110	60	36	italy	italy	PROPN
hjic-110	60	37	;	;	PUNCT
hjic-110	60	38	dichloromethane	dichloromethane	NOUN
hjic-110	60	39	(	(	PUNCT
hjic-110	60	40	99.95	99.95	NUM
hjic-110	60	41	%	%	NOUN
hjic-110	60	42	)	)	PUNCT
hjic-110	60	43	was	be	AUX
hjic-110	60	44	purchased	purchase	VERB
hjic-110	60	45	from	from	ADP
hjic-110	60	46	sds	sds	PROPN
hjic-110	60	47	,	,	PUNCT
hjic-110	60	48	france	france	PROPN
hjic-110	60	49	;	;	PUNCT
hjic-110	60	50	dimethylsulfoxide	dimethylsulfoxide	ADV
hjic-110	60	51	(	(	PUNCT
hjic-110	60	52	99.8	99.8	NUM
hjic-110	60	53	%	%	NOUN
hjic-110	60	54	)	)	PUNCT
hjic-110	60	55	was	be	AUX
hjic-110	60	56	supplied	supply	VERB
hjic-110	60	57	by	by	ADP
hjic-110	60	58	3d	3d	NOUN
hjic-110	60	59	-	-	PUNCT
hjic-110	60	60	spektrum	spektrum	NOUN
hjic-110	60	61	,	,	PUNCT
hjic-110	60	62	hungary	hungary	NOUN
hjic-110	60	63	;	;	PUNCT
hjic-110	60	64	potassium	potassium	NOUN
hjic-110	60	65	phosphate	phosphate	ADJ
hjic-110	60	66	monobasic	monobasic	NOUN
hjic-110	60	67	,	,	PUNCT
hjic-110	60	68	sodium	sodium	NOUN
hjic-110	60	69	phosphate	phosphate	NOUN
hjic-110	60	70	dibasic	dibasic	NOUN
hjic-110	60	71	dodecahydrate	dodecahydrate	NOUN
hjic-110	60	72	and	and	CCONJ
hjic-110	60	73	sodium	sodium	NOUN
hjic-110	60	74	chloride	chloride	NOUN
hjic-110	60	75	were	be	AUX
hjic-110	60	76	obtained	obtain	VERB
hjic-110	60	77	from	from	ADP
hjic-110	60	78	reanal	reanal	ADJ
hjic-110	60	79	,	,	PUNCT
hjic-110	60	80	hungary	hungary	PROPN
hjic-110	60	81	.	.	PUNCT
hjic-110	61	1	supercritical	supercritical	ADJ
hjic-110	61	2	antisolvent	antisolvent	PROPN
hjic-110	61	3	process	process	NOUN
hjic-110	61	4	the	the	DET
hjic-110	61	5	schematic	schematic	ADJ
hjic-110	61	6	diagram	diagram	NOUN
hjic-110	61	7	of	of	ADP
hjic-110	61	8	the	the	DET
hjic-110	61	9	sas	sas	PROPN
hjic-110	61	10	apparatus	apparatus	NOUN
hjic-110	61	11	is	be	AUX
hjic-110	61	12	shown	show	VERB
hjic-110	61	13	in	in	ADP
hjic-110	61	14	fig	fig	NOUN
hjic-110	61	15	.	.	PUNCT
hjic-110	62	1	2	2	X
hjic-110	62	2	.	.	X
hjic-110	62	3	feed	feed	NOUN
hjic-110	62	4	solutions	solution	NOUN
hjic-110	62	5	containing	contain	VERB
hjic-110	62	6	2	2	NUM
hjic-110	62	7	wt	wt	NOUN
hjic-110	62	8	.	.	NOUN
hjic-110	62	9	%	%	NOUN
hjic-110	62	10	api	api	NOUN
hjic-110	62	11	and	and	CCONJ
hjic-110	62	12	2	2	NUM
hjic-110	62	13	wt	wt	NOUN
hjic-110	62	14	.	.	NOUN
hjic-110	63	1	%	%	PROPN
hjic-110	63	2	excipient	excipient	NOUN
hjic-110	63	3	were	be	AUX
hjic-110	63	4	prepared	prepare	VERB
hjic-110	63	5	by	by	ADP
hjic-110	63	6	dissolving	dissolve	VERB
hjic-110	63	7	the	the	DET
hjic-110	63	8	calculated	calculate	VERB
hjic-110	63	9	amount	amount	NOUN
hjic-110	63	10	of	of	ADP
hjic-110	63	11	pharmaceutical	pharmaceutical	ADJ
hjic-110	63	12	ingredients	ingredient	NOUN
hjic-110	63	13	in	in	ADP
hjic-110	63	14	50	50	NUM
hjic-110	63	15	ml	ml	NOUN
hjic-110	63	16	dcm	dcm	PROPN
hjic-110	63	17	.	.	PROPN
hjic-110	64	1	feed	feed	NOUN
hjic-110	64	2	solution	solution	NOUN
hjic-110	64	3	(	(	PUNCT
hjic-110	64	4	6	6	NUM
hjic-110	64	5	)	)	PUNCT
hjic-110	64	6	was	be	AUX
hjic-110	64	7	dispersed	disperse	VERB
hjic-110	64	8	through	through	ADP
hjic-110	64	9	a	a	DET
hjic-110	64	10	capillary	capillary	ADJ
hjic-110	64	11	nozzle	nozzle	NOUN
hjic-110	64	12	(	(	PUNCT
hjic-110	64	13	125	125	NUM
hjic-110	64	14	μm	μm	NUM
hjic-110	64	15	i	i	PROPN
hjic-110	64	16	d	d	PROPN
hjic-110	64	17	)	)	PUNCT
hjic-110	64	18	(	(	PUNCT
hjic-110	64	19	8)	8)	NUM
hjic-110	64	20	in	in	ADP
hjic-110	64	21	a	a	DET
hjic-110	64	22	cocurrent	cocurrent	NOUN
hjic-110	64	23	scco2	scco2	PROPN
hjic-110	64	24	stream	stream	NOUN
hjic-110	64	25	.	.	PUNCT
hjic-110	65	1	feed	feed	NOUN
hjic-110	65	2	solution	solution	NOUN
hjic-110	65	3	was	be	AUX
hjic-110	65	4	delivered	deliver	VERB
hjic-110	65	5	by	by	ADP
hjic-110	65	6	a	a	DET
hjic-110	65	7	reciprocating	reciprocate	VERB
hjic-110	65	8	hplc	hplc	NOUN
hjic-110	65	9	pump	pump	NOUN
hjic-110	65	10	(	(	PUNCT
hjic-110	65	11	gilson	gilson	NOUN
hjic-110	65	12	307	307	NUM
hjic-110	65	13	,	,	PUNCT
hjic-110	65	14	france	france	PROPN
hjic-110	65	15	)	)	PUNCT
hjic-110	65	16	(	(	PUNCT
hjic-110	65	17	7	7	X
hjic-110	65	18	)	)	PUNCT
hjic-110	65	19	at	at	ADP
hjic-110	65	20	a	a	DET
hjic-110	65	21	flow	flow	NOUN
hjic-110	65	22	rate	rate	NOUN
hjic-110	65	23	of	of	ADP
hjic-110	65	24	3	3	NUM
hjic-110	65	25	ml	ml	NOUN
hjic-110	65	26	/	/	SYM
hjic-110	65	27	min	min	NOUN
hjic-110	65	28	,	,	PUNCT
hjic-110	65	29	co2	co2	NOUN
hjic-110	65	30	was	be	AUX
hjic-110	65	31	compressed	compress	VERB
hjic-110	65	32	to	to	ADP
hjic-110	65	33	80	80	NUM
hjic-110	65	34	bar	bar	NOUN
hjic-110	65	35	in	in	ADP
hjic-110	65	36	a	a	DET
hjic-110	65	37	watercooled	watercooled	ADJ
hjic-110	65	38	membrane	membrane	NOUN
hjic-110	65	39	pump	pump	NOUN
hjic-110	65	40	(	(	PUNCT
hjic-110	65	41	dosapro	dosapro	PROPN
hjic-110	65	42	milton	milton	PROPN
hjic-110	65	43	roy	roy	PROPN
hjic-110	65	44	,	,	PUNCT
hjic-110	65	45	france	france	PROPN
hjic-110	65	46	)	)	PUNCT
hjic-110	65	47	(	(	PUNCT
hjic-110	65	48	3	3	X
hjic-110	65	49	)	)	PUNCT
hjic-110	65	50	at	at	ADP
hjic-110	65	51	a	a	DET
hjic-110	65	52	flow	flow	NOUN
hjic-110	65	53	rate	rate	NOUN
hjic-110	65	54	of	of	ADP
hjic-110	65	55	10	10	NUM
hjic-110	65	56	g	g	NOUN
hjic-110	65	57	/	/	SYM
hjic-110	65	58	min	min	NOUN
hjic-110	65	59	.	.	NOUN
hjic-110	65	60	compressed	compress	VERB
hjic-110	65	61	co2	co2	NOUN
hjic-110	65	62	and	and	CCONJ
hjic-110	65	63	solution	solution	NOUN
hjic-110	65	64	were	be	AUX
hjic-110	65	65	both	both	PRON
hjic-110	65	66	heated	heated	ADJ
hjic-110	65	67	(	(	PUNCT
hjic-110	65	68	5	5	NUM
hjic-110	65	69	)	)	PUNCT
hjic-110	65	70	to	to	ADP
hjic-110	65	71	35	35	NUM
hjic-110	65	72	±	±	NUM
hjic-110	65	73	0.5	0.5	NUM
hjic-110	65	74	°	°	ADP
hjic-110	65	75	c	c	NOUN
hjic-110	65	76	before	before	ADP
hjic-110	65	77	entering	enter	VERB
hjic-110	65	78	the	the	DET
hjic-110	65	79	precipitation	precipitation	NOUN
hjic-110	65	80	vessel	vessel	NOUN
hjic-110	65	81	(	(	PUNCT
hjic-110	65	82	top	top	ADJ
hjic-110	65	83	industrie	industrie	PROPN
hjic-110	65	84	s.a	s.a	PROPN
hjic-110	65	85	.	.	PROPN
hjic-110	65	86	,	,	PUNCT
hjic-110	65	87	france	france	PROPN
hjic-110	65	88	)	)	PUNCT
hjic-110	65	89	(	(	PUNCT
hjic-110	65	90	9	9	NUM
hjic-110	65	91	)	)	PUNCT
hjic-110	65	92	.	.	PUNCT
hjic-110	66	1	fig	fig	NOUN
hjic-110	66	2	.	.	PUNCT
hjic-110	67	1	2	2	NUM
hjic-110	67	2	.	.	X
hjic-110	67	3	schematic	schematic	ADJ
hjic-110	67	4	diagram	diagram	NOUN
hjic-110	67	5	of	of	ADP
hjic-110	67	6	sas	sas	PROPN
hjic-110	67	7	apparatus	apparatus	PROPN
hjic-110	67	8	.	.	PUNCT
hjic-110	68	1	1	1	X
hjic-110	68	2	.	.	X
hjic-110	68	3	co2	co2	NOUN
hjic-110	68	4	source	source	NOUN
hjic-110	68	5	,	,	PUNCT
hjic-110	68	6	2	2	NUM
hjic-110	68	7	.	.	PUNCT
hjic-110	68	8	cooler	cool	ADJ
hjic-110	68	9	,	,	PUNCT
hjic-110	68	10	3	3	X
hjic-110	68	11	.	.	PUNCT
hjic-110	68	12	co2	co2	NOUN
hjic-110	68	13	metering	metering	NOUN
hjic-110	68	14	pump	pump	NOUN
hjic-110	68	15	,	,	PUNCT
hjic-110	68	16	4	4	NUM
hjic-110	68	17	.	.	X
hjic-110	68	18	bursting	bursting	NOUN
hjic-110	68	19	disc	disc	NOUN
hjic-110	68	20	,	,	PUNCT
hjic-110	68	21	5	5	NUM
hjic-110	68	22	.	.	PUNCT
hjic-110	68	23	heat	heat	NOUN
hjic-110	68	24	exchanger	exchanger	NOUN
hjic-110	68	25	,	,	PUNCT
hjic-110	68	26	6	6	NUM
hjic-110	68	27	.	.	PUNCT
hjic-110	68	28	solution	solution	NOUN
hjic-110	68	29	source	source	NOUN
hjic-110	68	30	,	,	PUNCT
hjic-110	68	31	7	7	NUM
hjic-110	68	32	.	.	PUNCT
hjic-110	68	33	solution	solution	NOUN
hjic-110	68	34	metering	metering	NOUN
hjic-110	68	35	pump	pump	NOUN
hjic-110	68	36	,	,	PUNCT
hjic-110	68	37	8	8	NUM
hjic-110	68	38	.	.	PUNCT
hjic-110	68	39	capillary	capillary	ADJ
hjic-110	68	40	nozzle	nozzle	NOUN
hjic-110	68	41	,	,	PUNCT
hjic-110	68	42	9	9	X
hjic-110	68	43	.	.	PUNCT
hjic-110	68	44	precipitation	precipitation	NOUN
hjic-110	68	45	vessel	vessel	NOUN
hjic-110	68	46	,	,	PUNCT
hjic-110	68	47	10	10	NUM
hjic-110	68	48	.	.	PUNCT
hjic-110	69	1	frit	frit	NOUN
hjic-110	69	2	filter	filter	NOUN
hjic-110	69	3	,	,	PUNCT
hjic-110	69	4	11	11	NUM
hjic-110	69	5	.	.	PUNCT
hjic-110	70	1	expansion	expansion	NOUN
hjic-110	70	2	valve	valve	NOUN
hjic-110	70	3	,	,	PUNCT
hjic-110	70	4	12	12	NUM
hjic-110	70	5	.	.	PUNCT
hjic-110	71	1	cold	cold	ADJ
hjic-110	71	2	trap	trap	NOUN
hjic-110	71	3	,	,	PUNCT
hjic-110	71	4	13	13	NUM
hjic-110	71	5	.	.	PUNCT
hjic-110	71	6	gas	gas	NOUN
hjic-110	71	7	flow	flow	NOUN
hjic-110	71	8	meter	meter	NOUN
hjic-110	71	9	.	.	PUNCT
hjic-110	72	1	particles	particle	NOUN
hjic-110	72	2	formed	form	VERB
hjic-110	72	3	by	by	ADP
hjic-110	72	4	the	the	DET
hjic-110	72	5	antisolvent	antisolvent	NOUN
hjic-110	72	6	effect	effect	NOUN
hjic-110	72	7	were	be	AUX
hjic-110	72	8	collected	collect	VERB
hjic-110	72	9	on	on	ADP
hjic-110	72	10	0.1	0.1	NUM
hjic-110	72	11	μm	μm	NUM
hjic-110	72	12	metal	metal	NOUN
hjic-110	72	13	frit	frit	NOUN
hjic-110	72	14	filter	filter	NOUN
hjic-110	72	15	(	(	PUNCT
hjic-110	72	16	10	10	NUM
hjic-110	72	17	)	)	PUNCT
hjic-110	72	18	and	and	CCONJ
hjic-110	72	19	washed	wash	VERB
hjic-110	72	20	with	with	ADP
hjic-110	72	21	pure	pure	ADJ
hjic-110	72	22	scco2	scco2	NOUN
hjic-110	72	23	for	for	SCONJ
hjic-110	72	24	30	30	NUM
hjic-110	72	25	min	min	NOUN
hjic-110	72	26	to	to	PART
hjic-110	72	27	remove	remove	VERB
hjic-110	72	28	residual	residual	ADJ
hjic-110	72	29	solvents	solvent	NOUN
hjic-110	72	30	.	.	PUNCT
hjic-110	73	1	a	a	DET
hjic-110	73	2	cold	cold	ADJ
hjic-110	73	3	trap	trap	NOUN
hjic-110	73	4	(	(	PUNCT
hjic-110	73	5	12	12	NUM
hjic-110	73	6	)	)	PUNCT
hjic-110	73	7	was	be	AUX
hjic-110	73	8	installed	instal	VERB
hjic-110	73	9	between	between	ADP
hjic-110	73	10	the	the	DET
hjic-110	73	11	heated	heated	ADJ
hjic-110	73	12	expansion	expansion	NOUN
hjic-110	73	13	43	43	NUM
hjic-110	73	14	valve	valve	NOUN
hjic-110	73	15	(	(	PUNCT
hjic-110	73	16	11	11	NUM
hjic-110	73	17	)	)	PUNCT
hjic-110	73	18	and	and	CCONJ
hjic-110	73	19	the	the	DET
hjic-110	73	20	flow	flow	NOUN
hjic-110	73	21	meter	meter	NOUN
hjic-110	73	22	(	(	PUNCT
hjic-110	73	23	13	13	NUM
hjic-110	73	24	)	)	PUNCT
hjic-110	73	25	to	to	PART
hjic-110	73	26	condense	condense	VERB
hjic-110	73	27	the	the	DET
hjic-110	73	28	organic	organic	ADJ
hjic-110	73	29	solvents	solvent	NOUN
hjic-110	73	30	.	.	PUNCT
hjic-110	74	1	pressure	pressure	NOUN
hjic-110	74	2	and	and	CCONJ
hjic-110	74	3	co2	co2	NOUN
hjic-110	74	4	flow	flow	NOUN
hjic-110	74	5	rate	rate	NOUN
hjic-110	74	6	were	be	AUX
hjic-110	74	7	manually	manually	ADV
hjic-110	74	8	controlled	control	VERB
hjic-110	74	9	.	.	PUNCT
hjic-110	75	1	solid	solid	ADJ
hjic-110	75	2	dispersions	dispersion	NOUN
hjic-110	75	3	were	be	AUX
hjic-110	75	4	dried	dry	VERB
hjic-110	75	5	in	in	ADP
hjic-110	75	6	a	a	DET
hjic-110	75	7	vacuum	vacuum	NOUN
hjic-110	75	8	oven	oven	NOUN
hjic-110	75	9	at	at	ADP
hjic-110	75	10	40	40	NUM
hjic-110	75	11	°	°	NOUN
hjic-110	75	12	c	c	NOUN
hjic-110	75	13	for	for	ADP
hjic-110	75	14	24	24	NUM
hjic-110	75	15	h	h	NOUN
hjic-110	75	16	so	so	SCONJ
hjic-110	75	17	that	that	SCONJ
hjic-110	75	18	residual	residual	ADJ
hjic-110	75	19	solvent	solvent	NOUN
hjic-110	75	20	contents	content	NOUN
hjic-110	75	21	are	be	AUX
hjic-110	75	22	comparable	comparable	ADJ
hjic-110	75	23	to	to	ADP
hjic-110	75	24	those	those	PRON
hjic-110	75	25	of	of	ADP
hjic-110	75	26	coevaporates	coevaporate	NOUN
hjic-110	75	27	.	.	PUNCT
hjic-110	76	1	coevaporation	coevaporation	NOUN
hjic-110	76	2	process	process	NOUN
hjic-110	76	3	coevaporates	coevaporate	NOUN
hjic-110	76	4	were	be	AUX
hjic-110	76	5	prepared	prepare	VERB
hjic-110	76	6	by	by	ADP
hjic-110	76	7	dissolving	dissolve	VERB
hjic-110	76	8	oxeglitazar	oxeglitazar	NOUN
hjic-110	76	9	and	and	CCONJ
hjic-110	76	10	pvp	pvp	VERB
hjic-110	76	11	k17	k17	PROPN
hjic-110	76	12	or	or	CCONJ
hjic-110	76	13	poloxamer	poloxamer	NOUN
hjic-110	76	14	407	407	NUM
hjic-110	76	15	in	in	ADP
hjic-110	76	16	a	a	DET
hjic-110	76	17	minimum	minimum	NOUN
hjic-110	76	18	amount	amount	NOUN
hjic-110	76	19	(	(	PUNCT
hjic-110	76	20	~20	~20	NOUN
hjic-110	76	21	ml	ml	NOUN
hjic-110	76	22	)	)	PUNCT
hjic-110	76	23	of	of	ADP
hjic-110	76	24	dcm	dcm	PROPN
hjic-110	76	25	.	.	PUNCT
hjic-110	77	1	the	the	DET
hjic-110	77	2	solvent	solvent	NOUN
hjic-110	77	3	was	be	AUX
hjic-110	77	4	rapidly	rapidly	ADV
hjic-110	77	5	removed	remove	VERB
hjic-110	77	6	under	under	ADP
hjic-110	77	7	reduced	reduced	ADJ
hjic-110	77	8	pressure	pressure	NOUN
hjic-110	77	9	in	in	ADP
hjic-110	77	10	a	a	DET
hjic-110	77	11	rotary	rotary	ADJ
hjic-110	77	12	evaporator	evaporator	NOUN
hjic-110	77	13	at	at	ADP
hjic-110	77	14	40	40	NUM
hjic-110	77	15	°	°	NOUN
hjic-110	77	16	c	c	NOUN
hjic-110	77	17	.	.	PUNCT
hjic-110	78	1	solid	solid	ADJ
hjic-110	78	2	dispersions	dispersion	NOUN
hjic-110	78	3	were	be	AUX
hjic-110	78	4	ground	grind	VERB
hjic-110	78	5	and	and	CCONJ
hjic-110	78	6	dried	dry	VERB
hjic-110	78	7	in	in	ADP
hjic-110	78	8	a	a	DET
hjic-110	78	9	vacuum	vacuum	NOUN
hjic-110	78	10	oven	oven	NOUN
hjic-110	78	11	at	at	ADP
hjic-110	78	12	40	40	NUM
hjic-110	78	13	°	°	NOUN
hjic-110	78	14	c	c	NOUN
hjic-110	78	15	for	for	ADP
hjic-110	78	16	24	24	NUM
hjic-110	78	17	h.	h.	PROPN
hjic-110	78	18	physical	physical	ADJ
hjic-110	78	19	mixture	mixture	NOUN
hjic-110	78	20	physical	physical	ADJ
hjic-110	78	21	mixtures	mixture	NOUN
hjic-110	78	22	of	of	ADP
hjic-110	78	23	oxeglitazar	oxeglitazar	NOUN
hjic-110	78	24	and	and	CCONJ
hjic-110	78	25	pvp	pvp	PROPN
hjic-110	78	26	k17	k17	PROPN
hjic-110	78	27	or	or	CCONJ
hjic-110	78	28	poloxamer	poloxamer	PROPN
hjic-110	78	29	407	407	NUM
hjic-110	78	30	used	use	VERB
hjic-110	78	31	in	in	ADP
hjic-110	78	32	the	the	DET
hjic-110	78	33	dissolution	dissolution	NOUN
hjic-110	78	34	studies	study	NOUN
hjic-110	78	35	and	and	CCONJ
hjic-110	78	36	ftir	ftir	VERB
hjic-110	78	37	analysis	analysis	NOUN
hjic-110	78	38	were	be	AUX
hjic-110	78	39	prepared	prepare	VERB
hjic-110	78	40	by	by	ADP
hjic-110	78	41	mixing	mix	VERB
hjic-110	78	42	the	the	DET
hjic-110	78	43	appropriate	appropriate	ADJ
hjic-110	78	44	amounts	amount	NOUN
hjic-110	78	45	of	of	ADP
hjic-110	78	46	pharmaceutical	pharmaceutical	ADJ
hjic-110	78	47	ingredients	ingredient	NOUN
hjic-110	78	48	in	in	ADP
hjic-110	78	49	a	a	DET
hjic-110	78	50	mortal	mortal	NOUN
hjic-110	78	51	until	until	SCONJ
hjic-110	78	52	a	a	DET
hjic-110	78	53	homogenous	homogenous	ADJ
hjic-110	78	54	mixture	mixture	NOUN
hjic-110	78	55	was	be	AUX
hjic-110	78	56	obtained	obtain	VERB
hjic-110	78	57	.	.	PUNCT
hjic-110	79	1	incorporated	incorporate	VERB
hjic-110	79	2	oxeglitazar	oxeglitazar	NOUN
hjic-110	79	3	(	(	PUNCT
hjic-110	79	4	raw	raw	ADJ
hjic-110	79	5	drug	drug	NOUN
hjic-110	79	6	)	)	PUNCT
hjic-110	79	7	contained	contain	VERB
hjic-110	79	8	exclusively	exclusively	ADV
hjic-110	79	9	the	the	DET
hjic-110	79	10	higher	high	ADJ
hjic-110	79	11	melting	melting	NOUN
hjic-110	79	12	polymorph	polymorph	NOUN
hjic-110	79	13	(	(	PUNCT
hjic-110	79	14	form	form	VERB
hjic-110	79	15	a	a	PRON
hjic-110	79	16	)	)	PUNCT
hjic-110	79	17	.	.	PUNCT
hjic-110	80	1	scanning	scan	VERB
hjic-110	80	2	electron	electron	NOUN
hjic-110	80	3	microscopy	microscopy	NOUN
hjic-110	80	4	(	(	PUNCT
hjic-110	80	5	sem	sem	NOUN
hjic-110	80	6	)	)	PUNCT
hjic-110	80	7	sem	sem	NOUN
hjic-110	80	8	micrographs	micrograph	NOUN
hjic-110	80	9	were	be	AUX
hjic-110	80	10	taken	take	VERB
hjic-110	80	11	using	use	VERB
hjic-110	80	12	philips	philip	NOUN
hjic-110	80	13	xl30	xl30	PROPN
hjic-110	80	14	esem	esem	ADJ
hjic-110	80	15	environmental	environmental	ADJ
hjic-110	80	16	scanning	scanning	NOUN
hjic-110	80	17	electron	electron	NOUN
hjic-110	80	18	microscope	microscope	NOUN
hjic-110	80	19	(	(	PUNCT
hjic-110	80	20	philips	philips	PROPN
hjic-110	80	21	analytical	analytical	PROPN
hjic-110	80	22	inc	inc	PROPN
hjic-110	80	23	.	.	PROPN
hjic-110	80	24	,	,	PUNCT
hjic-110	80	25	the	the	DET
hjic-110	80	26	netherlands	netherlands	PROPN
hjic-110	80	27	)	)	PUNCT
hjic-110	80	28	.	.	PUNCT
hjic-110	81	1	samples	sample	NOUN
hjic-110	81	2	were	be	AUX
hjic-110	81	3	coated	coat	VERB
hjic-110	81	4	with	with	ADP
hjic-110	81	5	gold	gold	NOUN
hjic-110	81	6	before	before	ADP
hjic-110	81	7	examination	examination	NOUN
hjic-110	81	8	(	(	PUNCT
hjic-110	81	9	cathode	cathode	NOUN
hjic-110	81	10	dispersion	dispersion	NOUN
hjic-110	81	11	)	)	PUNCT
hjic-110	81	12	.	.	PUNCT
hjic-110	82	1	powder	powder	NOUN
hjic-110	82	2	x	x	PROPN
hjic-110	82	3	-	-	NOUN
hjic-110	82	4	ray	ray	NOUN
hjic-110	82	5	diffraction	diffraction	NOUN
hjic-110	82	6	(	(	PUNCT
hjic-110	82	7	xrd	xrd	PROPN
hjic-110	82	8	)	)	PUNCT
hjic-110	82	9	xrd	xrd	PROPN
hjic-110	82	10	patterns	pattern	NOUN
hjic-110	82	11	of	of	ADP
hjic-110	82	12	sas	sas	PROPN
hjic-110	82	13	powders	powder	NOUN
hjic-110	82	14	were	be	AUX
hjic-110	82	15	obtained	obtain	VERB
hjic-110	82	16	using	use	VERB
hjic-110	82	17	a	a	DET
hjic-110	82	18	philips	philips	PROPN
hjic-110	82	19	analytical	analytical	ADJ
hjic-110	82	20	x	x	NOUN
hjic-110	82	21	-	-	NOUN
hjic-110	82	22	ray	ray	NOUN
hjic-110	82	23	diffractometer	diffractometer	NOUN
hjic-110	82	24	mpd3710	mpd3710	ADV
hjic-110	82	25	(	(	PUNCT
hjic-110	82	26	philips	philips	PROPN
hjic-110	82	27	analytical	analytical	PROPN
hjic-110	82	28	inc	inc	PROPN
hjic-110	82	29	.	.	PROPN
hjic-110	82	30	,	,	PUNCT
hjic-110	82	31	the	the	DET
hjic-110	82	32	netherlands	netherlands	PROPN
hjic-110	82	33	)	)	PUNCT
hjic-110	82	34	.	.	PUNCT
hjic-110	83	1	ground	ground	NOUN
hjic-110	83	2	powders	powder	NOUN
hjic-110	83	3	were	be	AUX
hjic-110	83	4	placed	place	VERB
hjic-110	83	5	in	in	ADP
hjic-110	83	6	the	the	DET
hjic-110	83	7	cavity	cavity	NOUN
hjic-110	83	8	of	of	ADP
hjic-110	83	9	an	an	DET
hjic-110	83	10	aluminum	aluminum	NOUN
hjic-110	83	11	sample	sample	NOUN
hjic-110	83	12	holder	holder	NOUN
hjic-110	83	13	and	and	CCONJ
hjic-110	83	14	flattened	flatten	VERB
hjic-110	83	15	with	with	ADP
hjic-110	83	16	a	a	DET
hjic-110	83	17	glass	glass	NOUN
hjic-110	83	18	slide	slide	NOUN
hjic-110	83	19	.	.	PUNCT
hjic-110	84	1	samples	sample	NOUN
hjic-110	84	2	were	be	AUX
hjic-110	84	3	scanned	scan	VERB
hjic-110	84	4	over	over	ADP
hjic-110	84	5	the	the	DET
hjic-110	84	6	range	range	NOUN
hjic-110	84	7	of	of	ADP
hjic-110	84	8	4.0	4.0	NUM
hjic-110	84	9	-	-	SYM
hjic-110	84	10	47.0	47.0	NUM
hjic-110	84	11	°	°	NOUN
hjic-110	84	12	2θ	2θ	NUM
hjic-110	84	13	with	with	ADP
hjic-110	84	14	a	a	DET
hjic-110	84	15	step	step	NOUN
hjic-110	84	16	size	size	NOUN
hjic-110	84	17	of	of	ADP
hjic-110	84	18	0.020	0.020	NUM
hjic-110	84	19	°	°	NUM
hjic-110	84	20	2	2	NUM
hjic-110	84	21	θ	θ	NOUN
hjic-110	84	22	and	and	CCONJ
hjic-110	84	23	a	a	DET
hjic-110	84	24	count	count	NOUN
hjic-110	84	25	time	time	NOUN
hjic-110	84	26	of	of	ADP
hjic-110	84	27	2	2	NUM
hjic-110	84	28	s	s	NOUN
hjic-110	84	29	per	per	ADP
hjic-110	84	30	step	step	NOUN
hjic-110	84	31	using	use	VERB
hjic-110	84	32	co	co	ADP
hjic-110	84	33	kα	kα	PROPN
hjic-110	84	34	source	source	NOUN
hjic-110	84	35	with	with	ADP
hjic-110	84	36	a	a	DET
hjic-110	84	37	wavelength	wavelength	NOUN
hjic-110	84	38	of	of	ADP
hjic-110	84	39	1.78896	1.78896	NUM
hjic-110	84	40	å	å	NOUN
hjic-110	84	41	.	.	PUNCT
hjic-110	85	1	coevaporates	coevaporate	NOUN
hjic-110	85	2	were	be	AUX
hjic-110	85	3	analyzed	analyze	VERB
hjic-110	85	4	on	on	ADP
hjic-110	85	5	philips	philips	PROPN
hjic-110	85	6	analytical	analytical	ADJ
hjic-110	85	7	x	x	NOUN
hjic-110	85	8	-	-	NOUN
hjic-110	85	9	ray	ray	NOUN
hjic-110	85	10	diffractometer	diffractometer	NOUN
hjic-110	85	11	b.v	b.v	PROPN
hjic-110	85	12	.	.	PUNCT
hjic-110	86	1	pw3710	pw3710	PROPN
hjic-110	86	2	(	(	PUNCT
hjic-110	86	3	philips	philips	PROPN
hjic-110	86	4	analytical	analytical	PROPN
hjic-110	86	5	inc	inc	PROPN
hjic-110	86	6	.	.	PROPN
hjic-110	86	7	,	,	PUNCT
hjic-110	86	8	the	the	DET
hjic-110	86	9	netherlands	netherlands	PROPN
hjic-110	86	10	)	)	PUNCT
hjic-110	86	11	over	over	ADP
hjic-110	86	12	the	the	DET
hjic-110	86	13	range	range	NOUN
hjic-110	86	14	of	of	ADP
hjic-110	86	15	4.0	4.0	NUM
hjic-110	86	16	-	-	SYM
hjic-110	86	17	40.0	40.0	NUM
hjic-110	86	18	°	°	NOUN
hjic-110	86	19	2	2	NUM
hjic-110	86	20	θ	θ	NOUN
hjic-110	86	21	with	with	ADP
hjic-110	86	22	a	a	DET
hjic-110	86	23	step	step	NOUN
hjic-110	86	24	size	size	NOUN
hjic-110	86	25	of	of	ADP
hjic-110	86	26	0.020	0.020	NUM
hjic-110	86	27	°	°	NUM
hjic-110	86	28	2	2	NUM
hjic-110	86	29	θ	θ	NOUN
hjic-110	86	30	and	and	CCONJ
hjic-110	86	31	a	a	DET
hjic-110	86	32	count	count	NOUN
hjic-110	86	33	time	time	NOUN
hjic-110	86	34	of	of	ADP
hjic-110	86	35	1	1	NUM
hjic-110	86	36	s	s	NOUN
hjic-110	86	37	per	per	ADP
hjic-110	86	38	step	step	NOUN
hjic-110	86	39	using	use	VERB
hjic-110	86	40	cu	cu	PROPN
hjic-110	86	41	source	source	NOUN
hjic-110	86	42	(	(	PUNCT
hjic-110	86	43	λ	λ	X
hjic-110	86	44	=	=	NOUN
hjic-110	86	45	1	1	NUM
hjic-110	86	46	.	.	NUM
hjic-110	86	47	54056	54056	NUM
hjic-110	87	1	å	å	NOUN
hjic-110	87	2	)	)	PUNCT
hjic-110	87	3	.	.	PUNCT
hjic-110	88	1	fourier	fourier	PROPN
hjic-110	88	2	transform	transform	VERB
hjic-110	88	3	infrared	infrared	ADJ
hjic-110	88	4	spectroscopy	spectroscopy	NOUN
hjic-110	88	5	(	(	PUNCT
hjic-110	88	6	ftir	ftir	PROPN
hjic-110	88	7	)	)	PUNCT
hjic-110	88	8	ftir	ftir	VERB
hjic-110	88	9	analysis	analysis	NOUN
hjic-110	88	10	was	be	AUX
hjic-110	88	11	carried	carry	VERB
hjic-110	88	12	out	out	ADP
hjic-110	88	13	on	on	ADP
hjic-110	88	14	a	a	DET
hjic-110	88	15	shimadzu	shimadzu	ADJ
hjic-110	88	16	ftir8300	ftir8300	PROPN
hjic-110	88	17	spectrometer	spectrometer	NOUN
hjic-110	88	18	(	(	PUNCT
hjic-110	88	19	shimadzu	shimadzu	PROPN
hjic-110	88	20	corp	corp	PROPN
hjic-110	88	21	.	.	PROPN
hjic-110	88	22	,	,	PUNCT
hjic-110	88	23	japan	japan	PROPN
hjic-110	88	24	)	)	PUNCT
hjic-110	88	25	equipped	equip	VERB
hjic-110	88	26	with	with	ADP
hjic-110	88	27	a	a	DET
hjic-110	88	28	dlatgs	dlatgs	NOUN
hjic-110	88	29	detector	detector	NOUN
hjic-110	88	30	.	.	PUNCT
hjic-110	89	1	kbr	kbr	PROPN
hjic-110	89	2	pellets	pellet	NOUN
hjic-110	89	3	were	be	AUX
hjic-110	89	4	prepared	prepare	VERB
hjic-110	89	5	(	(	PUNCT
hjic-110	89	6	2	2	NUM
hjic-110	89	7	mg	mg	PROPN
hjic-110	89	8	sample	sample	NOUN
hjic-110	89	9	in	in	ADP
hjic-110	89	10	200	200	NUM
hjic-110	89	11	mg	mg	PROPN
hjic-110	89	12	kbr	kbr	PROPN
hjic-110	89	13	)	)	PUNCT
hjic-110	89	14	and	and	CCONJ
hjic-110	89	15	scanned	scan	VERB
hjic-110	89	16	over	over	ADP
hjic-110	89	17	a	a	DET
hjic-110	89	18	range	range	NOUN
hjic-110	89	19	of	of	ADP
hjic-110	89	20	400–3200	400–3200	NUM
hjic-110	89	21	cm–1	cm–1	X
hjic-110	89	22	with	with	ADP
hjic-110	89	23	a	a	DET
hjic-110	89	24	resolution	resolution	NOUN
hjic-110	89	25	of	of	ADP
hjic-110	89	26	2	2	NUM
hjic-110	89	27	cm-1	cm-1	NOUN
hjic-110	89	28	.	.	PUNCT
hjic-110	90	1	spectra	spectra	PROPN
hjic-110	90	2	were	be	AUX
hjic-110	90	3	obtained	obtain	VERB
hjic-110	90	4	by	by	ADP
hjic-110	90	5	coadding	coadde	VERB
hjic-110	90	6	100	100	NUM
hjic-110	90	7	scans	scan	NOUN
hjic-110	90	8	in	in	ADP
hjic-110	90	9	transmission	transmission	NOUN
hjic-110	90	10	mode	mode	NOUN
hjic-110	90	11	.	.	PUNCT
hjic-110	91	1	the	the	DET
hjic-110	91	2	software	software	NOUN
hjic-110	91	3	used	use	VERB
hjic-110	91	4	for	for	ADP
hjic-110	91	5	the	the	DET
hjic-110	91	6	data	datum	NOUN
hjic-110	91	7	analysis	analysis	NOUN
hjic-110	91	8	was	be	AUX
hjic-110	91	9	hyper	hyper	ADJ
hjic-110	91	10	-	-	ADJ
hjic-110	91	11	ir	ir	ADJ
hjic-110	91	12	(	(	PUNCT
hjic-110	91	13	shimadzu	shimadzu	PROPN
hjic-110	91	14	corp	corp	PROPN
hjic-110	91	15	.	.	PROPN
hjic-110	91	16	,	,	PUNCT
hjic-110	91	17	japan	japan	PROPN
hjic-110	91	18	)	)	PUNCT
hjic-110	91	19	.	.	PUNCT
hjic-110	92	1	gas	gas	NOUN
hjic-110	92	2	chromatography	chromatography	NOUN
hjic-110	92	3	(	(	PUNCT
hjic-110	92	4	gc	gc	PROPN
hjic-110	92	5	)	)	PUNCT
hjic-110	92	6	residual	residual	ADJ
hjic-110	92	7	dcm	dcm	NOUN
hjic-110	92	8	in	in	ADP
hjic-110	92	9	solid	solid	ADJ
hjic-110	92	10	dispersions	dispersion	NOUN
hjic-110	92	11	was	be	AUX
hjic-110	92	12	assessed	assess	VERB
hjic-110	92	13	using	use	VERB
hjic-110	92	14	hp	hp	PROPN
hjic-110	92	15	8590	8590	NUM
hjic-110	92	16	gas	gas	NOUN
hjic-110	92	17	chromatograph	chromatograph	NOUN
hjic-110	92	18	(	(	PUNCT
hjic-110	92	19	hewlet	hewlet	NOUN
hjic-110	92	20	packard	packard	PROPN
hjic-110	92	21	,	,	PUNCT
hjic-110	92	22	germany	germany	PROPN
hjic-110	92	23	)	)	PUNCT
hjic-110	92	24	with	with	ADP
hjic-110	92	25	flame	flame	NOUN
hjic-110	92	26	ionization	ionization	NOUN
hjic-110	92	27	(	(	PUNCT
hjic-110	92	28	fid	fid	NOUN
hjic-110	92	29	)	)	PUNCT
hjic-110	92	30	detector	detector	NOUN
hjic-110	92	31	.	.	PUNCT
hjic-110	93	1	powders	powder	NOUN
hjic-110	93	2	were	be	AUX
hjic-110	93	3	dissolved	dissolve	VERB
hjic-110	93	4	in	in	ADP
hjic-110	93	5	dmso	dmso	NOUN
hjic-110	93	6	and	and	CCONJ
hjic-110	93	7	directly	directly	ADV
hjic-110	93	8	injected	inject	VERB
hjic-110	93	9	in	in	ADP
hjic-110	93	10	triplicate	triplicate	PROPN
hjic-110	93	11	(	(	PUNCT
hjic-110	93	12	2.0	2.0	NUM
hjic-110	93	13	μl	μl	NOUN
hjic-110	93	14	)	)	PUNCT
hjic-110	93	15	on	on	ADP
hjic-110	93	16	a	a	DET
hjic-110	93	17	chrompack	chrompack	NOUN
hjic-110	93	18	fused	fuse	VERB
hjic-110	93	19	silica	silica	NOUN
hjic-110	93	20	column	column	NOUN
hjic-110	93	21	(	(	PUNCT
hjic-110	93	22	25	25	NUM
hjic-110	93	23	m	m	NOUN
hjic-110	93	24	x	x	NOUN
hjic-110	93	25	0.53	0.53	NUM
hjic-110	93	26	mm	mm	NOUN
hjic-110	93	27	)	)	PUNCT
hjic-110	93	28	with	with	ADP
hjic-110	93	29	poraplot	poraplot	NOUN
hjic-110	93	30	q	q	NOUN
hjic-110	93	31	coating	coating	NOUN
hjic-110	93	32	(	(	PUNCT
hjic-110	93	33	chrompack	chrompack	NOUN
hjic-110	93	34	international	international	PROPN
hjic-110	93	35	,	,	PUNCT
hjic-110	93	36	the	the	DET
hjic-110	93	37	netherlands	netherlands	PROPN
hjic-110	93	38	)	)	PUNCT
hjic-110	93	39	.	.	PUNCT
hjic-110	94	1	samples	sample	NOUN
hjic-110	94	2	were	be	AUX
hjic-110	94	3	analyzed	analyze	VERB
hjic-110	94	4	using	use	VERB
hjic-110	94	5	ar	ar	PROPN
hjic-110	94	6	carrier	carrier	NOUN
hjic-110	94	7	gas	gas	NOUN
hjic-110	94	8	at	at	ADP
hjic-110	94	9	a	a	DET
hjic-110	94	10	constant	constant	ADJ
hjic-110	94	11	oven	oven	NOUN
hjic-110	94	12	temperature	temperature	NOUN
hjic-110	94	13	of	of	ADP
hjic-110	94	14	210	210	NUM
hjic-110	94	15	°	°	NOUN
hjic-110	94	16	c	c	NOUN
hjic-110	94	17	while	while	SCONJ
hjic-110	94	18	the	the	DET
hjic-110	94	19	injector	injector	NOUN
hjic-110	94	20	and	and	CCONJ
hjic-110	94	21	detector	detector	NOUN
hjic-110	94	22	temperatures	temperature	NOUN
hjic-110	94	23	were	be	AUX
hjic-110	94	24	maintained	maintain	VERB
hjic-110	94	25	at	at	ADP
hjic-110	94	26	260	260	NUM
hjic-110	94	27	°	°	NOUN
hjic-110	94	28	c	c	NOUN
hjic-110	94	29	.	.	PUNCT
hjic-110	95	1	the	the	DET
hjic-110	95	2	method	method	NOUN
hjic-110	95	3	of	of	ADP
hjic-110	95	4	external	external	ADJ
hjic-110	95	5	standardization	standardization	NOUN
hjic-110	95	6	was	be	AUX
hjic-110	95	7	used	use	VERB
hjic-110	95	8	to	to	PART
hjic-110	95	9	calculate	calculate	VERB
hjic-110	95	10	the	the	DET
hjic-110	95	11	residual	residual	ADJ
hjic-110	95	12	solvent	solvent	NOUN
hjic-110	95	13	content	content	NOUN
hjic-110	95	14	.	.	PUNCT
hjic-110	96	1	uv	uv	NOUN
hjic-110	96	2	/	/	SYM
hjic-110	96	3	vis	vis	X
hjic-110	96	4	spectroscopy	spectroscopy	VERB
hjic-110	96	5	the	the	DET
hjic-110	96	6	drug	drug	NOUN
hjic-110	96	7	content	content	NOUN
hjic-110	96	8	of	of	ADP
hjic-110	96	9	formulations	formulation	NOUN
hjic-110	96	10	was	be	AUX
hjic-110	96	11	determined	determine	VERB
hjic-110	96	12	using	use	VERB
hjic-110	96	13	metertech	metertech	NOUN
hjic-110	96	14	uv	uv	NOUN
hjic-110	96	15	/	/	SYM
hjic-110	96	16	vis	vis	X
hjic-110	96	17	sp8001	sp8001	NOUN
hjic-110	96	18	spectrophotometer	spectrophotometer	NOUN
hjic-110	96	19	(	(	PUNCT
hjic-110	96	20	metertech	metertech	PROPN
hjic-110	96	21	inc	inc	PROPN
hjic-110	96	22	.	.	PROPN
hjic-110	96	23	,	,	PUNCT
hjic-110	96	24	taiwan	taiwan	PROPN
hjic-110	96	25	)	)	PUNCT
hjic-110	96	26	.	.	PUNCT
hjic-110	97	1	formulations	formulation	NOUN
hjic-110	97	2	were	be	AUX
hjic-110	97	3	dissolved	dissolve	VERB
hjic-110	97	4	in	in	ADP
hjic-110	97	5	ethanol	ethanol	NOUN
hjic-110	97	6	and	and	CCONJ
hjic-110	97	7	analyzed	analyze	VERB
hjic-110	97	8	at	at	ADP
hjic-110	97	9	292.0	292.0	NUM
hjic-110	97	10	nm	nm	NOUN
hjic-110	97	11	in	in	ADP
hjic-110	97	12	duplicate	duplicate	NOUN
hjic-110	97	13	after	after	ADP
hjic-110	97	14	appropriate	appropriate	ADJ
hjic-110	97	15	dilution	dilution	NOUN
hjic-110	97	16	.	.	PUNCT
hjic-110	98	1	solubility	solubility	NOUN
hjic-110	98	2	measurement	measurement	VERB
hjic-110	98	3	an	an	DET
hjic-110	98	4	excess	excess	ADJ
hjic-110	98	5	amount	amount	NOUN
hjic-110	98	6	(	(	PUNCT
hjic-110	98	7	50	50	NUM
hjic-110	98	8	mg	mg	NOUN
hjic-110	98	9	)	)	PUNCT
hjic-110	98	10	of	of	ADP
hjic-110	98	11	oxeglitazar	oxeglitazar	NOUN
hjic-110	98	12	was	be	AUX
hjic-110	98	13	added	add	VERB
hjic-110	98	14	to	to	ADP
hjic-110	98	15	20	20	NUM
hjic-110	98	16	ml	ml	NOUN
hjic-110	98	17	of	of	ADP
hjic-110	98	18	ph	ph	ADJ
hjic-110	98	19	7.4	7.4	NUM
hjic-110	98	20	phosphate	phosphate	NOUN
hjic-110	98	21	buffer	buffer	NOUN
hjic-110	98	22	medium	medium	NOUN
hjic-110	98	23	(	(	PUNCT
hjic-110	98	24	6.4	6.4	NUM
hjic-110	98	25	g	g	PROPN
hjic-110	98	26	na2hpo4·12	na2hpo4·12	PROPN
hjic-110	98	27	h2o	h2o	PROPN
hjic-110	98	28	;	;	PUNCT
hjic-110	98	29	0.6	0.6	NUM
hjic-110	98	30	g	g	PROPN
hjic-110	98	31	kh2po4	kh2po4	NOUN
hjic-110	98	32	and	and	CCONJ
hjic-110	98	33	5.85	5.85	NUM
hjic-110	98	34	g	g	PROPN
hjic-110	98	35	nacl	nacl	NOUN
hjic-110	98	36	dissolved	dissolve	VERB
hjic-110	98	37	in	in	ADP
hjic-110	98	38	1000	1000	NUM
hjic-110	98	39	ml	ml	NOUN
hjic-110	98	40	distilled	distil	VERB
hjic-110	98	41	water	water	NOUN
hjic-110	98	42	)	)	PUNCT
hjic-110	98	43	having	have	VERB
hjic-110	98	44	different	different	ADJ
hjic-110	98	45	concentrations	concentration	NOUN
hjic-110	98	46	of	of	ADP
hjic-110	98	47	pvp	pvp	PROPN
hjic-110	98	48	k17	k17	PROPN
hjic-110	98	49	or	or	CCONJ
hjic-110	98	50	poloxamer	poloxamer	PROPN
hjic-110	98	51	407	407	NUM
hjic-110	98	52	.	.	PUNCT
hjic-110	99	1	solutions	solution	NOUN
hjic-110	99	2	were	be	AUX
hjic-110	99	3	rotated	rotate	VERB
hjic-110	99	4	in	in	ADP
hjic-110	99	5	water	water	NOUN
hjic-110	99	6	-	-	PUNCT
hjic-110	99	7	jacketed	jacket	VERB
hjic-110	99	8	flasks	flask	NOUN
hjic-110	99	9	at	at	ADP
hjic-110	99	10	constant	constant	ADJ
hjic-110	99	11	temperature	temperature	NOUN
hjic-110	99	12	(	(	PUNCT
hjic-110	99	13	37	37	NUM
hjic-110	99	14	±	±	NUM
hjic-110	99	15	0.5	0.5	NUM
hjic-110	99	16	°	°	ADP
hjic-110	99	17	c	c	NOUN
hjic-110	99	18	)	)	PUNCT
hjic-110	99	19	.	.	PUNCT
hjic-110	100	1	after	after	ADP
hjic-110	100	2	24	24	NUM
hjic-110	100	3	h	h	NOUN
hjic-110	100	4	,	,	PUNCT
hjic-110	100	5	suspensions	suspension	NOUN
hjic-110	100	6	were	be	AUX
hjic-110	100	7	filtered	filter	VERB
hjic-110	100	8	through	through	ADP
hjic-110	100	9	a	a	DET
hjic-110	100	10	disposable	disposable	ADJ
hjic-110	100	11	syringe	syringe	NOUN
hjic-110	100	12	filter	filter	NOUN
hjic-110	100	13	(	(	PUNCT
hjic-110	100	14	0.22	0.22	NUM
hjic-110	100	15	μm	μm	NOUN
hjic-110	100	16	)	)	PUNCT
hjic-110	100	17	and	and	CCONJ
hjic-110	100	18	diluted	dilute	VERB
hjic-110	100	19	with	with	ADP
hjic-110	100	20	the	the	DET
hjic-110	100	21	dissolution	dissolution	NOUN
hjic-110	100	22	media	medium	NOUN
hjic-110	100	23	.	.	PUNCT
hjic-110	101	1	the	the	DET
hjic-110	101	2	amount	amount	NOUN
hjic-110	101	3	of	of	ADP
hjic-110	101	4	dissolved	dissolve	VERB
hjic-110	101	5	oxeglitazar	oxeglitazar	NOUN
hjic-110	101	6	was	be	AUX
hjic-110	101	7	quantified	quantify	VERB
hjic-110	101	8	using	use	VERB
hjic-110	101	9	metertech	metertech	NOUN
hjic-110	101	10	uv	uv	NOUN
hjic-110	101	11	/	/	SYM
hjic-110	101	12	vis	vis	X
hjic-110	101	13	sp8001	sp8001	NOUN
hjic-110	101	14	spectrophotometer	spectrophotometer	NOUN
hjic-110	101	15	(	(	PUNCT
hjic-110	101	16	metertech	metertech	PROPN
hjic-110	101	17	inc	inc	PROPN
hjic-110	101	18	.	.	PROPN
hjic-110	101	19	,	,	PUNCT
hjic-110	101	20	taiwan	taiwan	PROPN
hjic-110	101	21	)	)	PUNCT
hjic-110	101	22	.	.	PUNCT
hjic-110	102	1	solubility	solubility	NOUN
hjic-110	102	2	measurements	measurement	NOUN
hjic-110	102	3	were	be	AUX
hjic-110	102	4	carried	carry	VERB
hjic-110	102	5	out	out	ADP
hjic-110	102	6	in	in	ADP
hjic-110	102	7	triplicate	triplicate	NOUN
hjic-110	102	8	.	.	PUNCT
hjic-110	103	1	dissolution	dissolution	PROPN
hjic-110	103	2	studies	study	NOUN
hjic-110	103	3	dissolution	dissolution	NOUN
hjic-110	103	4	tests	test	NOUN
hjic-110	103	5	were	be	AUX
hjic-110	103	6	performed	perform	VERB
hjic-110	103	7	in	in	ADP
hjic-110	103	8	triplicate	triplicate	NOUN
hjic-110	103	9	in	in	ADP
hjic-110	103	10	ph	ph	ADJ
hjic-110	103	11	7.4	7.4	NUM
hjic-110	103	12	phosphate	phosphate	NOUN
hjic-110	103	13	buffer	buffer	NOUN
hjic-110	103	14	medium	medium	NOUN
hjic-110	103	15	.	.	PUNCT
hjic-110	104	1	about	about	ADV
hjic-110	104	2	100	100	NUM
hjic-110	104	3	mg	mg	NUM
hjic-110	104	4	of	of	ADP
hjic-110	104	5	powder	powder	NOUN
hjic-110	104	6	equivalent	equivalent	ADJ
hjic-110	104	7	to	to	ADP
hjic-110	104	8	~	~	PUNCT
hjic-110	104	9	50	50	NUM
hjic-110	104	10	mg	mg	NOUN
hjic-110	104	11	oxeglitazar	oxeglitazar	NOUN
hjic-110	104	12	were	be	AUX
hjic-110	104	13	added	add	VERB
hjic-110	104	14	to	to	ADP
hjic-110	104	15	1000	1000	NUM
hjic-110	104	16	ml	ml	NOUN
hjic-110	104	17	dissolution	dissolution	ADJ
hjic-110	104	18	medium	medium	ADJ
hjic-110	104	19	.	.	PUNCT
hjic-110	104	20	bath	bath	NOUN
hjic-110	104	21	temperature	temperature	NOUN
hjic-110	104	22	and	and	CCONJ
hjic-110	104	23	paddle	paddle	NOUN
hjic-110	104	24	speed	speed	NOUN
hjic-110	104	25	were	be	AUX
hjic-110	104	26	set	set	VERB
hjic-110	104	27	at	at	ADP
hjic-110	104	28	37	37	NUM
hjic-110	104	29	±	±	NUM
hjic-110	104	30	0.5	0.5	NUM
hjic-110	104	31	°	°	ADP
hjic-110	104	32	c	c	NOUN
hjic-110	104	33	and	and	CCONJ
hjic-110	104	34	75	75	NUM
hjic-110	104	35	rpm	rpm	NOUN
hjic-110	104	36	.	.	PUNCT
hjic-110	105	1	aliquots	aliquot	NOUN
hjic-110	105	2	of	of	ADP
hjic-110	105	3	10	10	NUM
hjic-110	105	4	ml	ml	NOUN
hjic-110	105	5	were	be	AUX
hjic-110	105	6	withdrawn	withdraw	VERB
hjic-110	105	7	through	through	ADP
hjic-110	105	8	a	a	DET
hjic-110	105	9	filtering	filter	VERB
hjic-110	105	10	rod	rod	NOUN
hjic-110	105	11	(	(	PUNCT
hjic-110	105	12	2	2	NUM
hjic-110	105	13	μm	μm	NUM
hjic-110	105	14	)	)	PUNCT
hjic-110	105	15	at	at	ADP
hjic-110	105	16	5	5	NUM
hjic-110	105	17	,	,	PUNCT
hjic-110	105	18	10	10	NUM
hjic-110	105	19	,	,	PUNCT
hjic-110	105	20	15	15	NUM
hjic-110	105	21	,	,	PUNCT
hjic-110	105	22	30	30	NUM
hjic-110	105	23	,	,	PUNCT
hjic-110	105	24	45	45	NUM
hjic-110	105	25	,	,	PUNCT
hjic-110	105	26	60	60	NUM
hjic-110	105	27	and	and	CCONJ
hjic-110	105	28	120	120	NUM
hjic-110	105	29	min	min	NOUN
hjic-110	105	30	.	.	PROPN
hjic-110	105	31	properly	properly	ADV
hjic-110	105	32	diluted	dilute	VERB
hjic-110	105	33	solutions	solution	NOUN
hjic-110	105	34	were	be	AUX
hjic-110	105	35	analyzed	analyze	VERB
hjic-110	105	36	on	on	ADP
hjic-110	105	37	metertech	metertech	NOUN
hjic-110	105	38	uv	uv	NOUN
hjic-110	105	39	/	/	SYM
hjic-110	105	40	vis	vis	X
hjic-110	105	41	sp8001	sp8001	NOUN
hjic-110	105	42	spectrophotometer	spectrophotometer	NOUN
hjic-110	105	43	(	(	PUNCT
hjic-110	105	44	metertech	metertech	PROPN
hjic-110	105	45	inc	inc	PROPN
hjic-110	105	46	.	.	PROPN
hjic-110	105	47	,	,	PUNCT
hjic-110	105	48	taiwan	taiwan	PROPN
hjic-110	105	49	)	)	PUNCT
hjic-110	105	50	at	at	ADP
hjic-110	105	51	λ	λ	X
hjic-110	105	52	=	=	PROPN
hjic-110	105	53	292.0	292.0	NUM
hjic-110	105	54	nm	nm	NOUN
hjic-110	105	55	.	.	PUNCT
hjic-110	106	1	error	error	NOUN
hjic-110	106	2	bars	bar	NOUN
hjic-110	106	3	represent	represent	VERB
hjic-110	106	4	the	the	DET
hjic-110	106	5	standard	standard	ADJ
hjic-110	106	6	error	error	NOUN
hjic-110	106	7	of	of	ADP
hjic-110	106	8	the	the	DET
hjic-110	106	9	mean	mean	NOUN
hjic-110	106	10	.	.	PUNCT
hjic-110	107	1	44	44	NUM
hjic-110	107	2	results	result	NOUN
hjic-110	107	3	particle	particle	NOUN
hjic-110	107	4	morphology	morphology	NOUN
hjic-110	107	5	sem	sem	NOUN
hjic-110	107	6	micrograph	micrograph	NOUN
hjic-110	107	7	of	of	ADP
hjic-110	107	8	the	the	DET
hjic-110	107	9	raw	raw	ADJ
hjic-110	107	10	drug	drug	NOUN
hjic-110	107	11	prepared	prepare	VERB
hjic-110	107	12	by	by	ADP
hjic-110	107	13	cooling	cool	VERB
hjic-110	107	14	crystallization	crystallization	NOUN
hjic-110	107	15	showed	show	VERB
hjic-110	107	16	thin	thin	ADJ
hjic-110	107	17	needle	needle	NOUN
hjic-110	107	18	-	-	PUNCT
hjic-110	107	19	like	like	ADJ
hjic-110	107	20	crystals	crystal	NOUN
hjic-110	107	21	(	(	PUNCT
hjic-110	107	22	fig	fig	NOUN
hjic-110	107	23	.	.	PUNCT
hjic-110	107	24	3a	3a	NUM
hjic-110	107	25	)	)	PUNCT
hjic-110	107	26	.	.	PUNCT
hjic-110	108	1	computer	computer	NOUN
hjic-110	108	2	simulation	simulation	NOUN
hjic-110	108	3	(	(	PUNCT
hjic-110	108	4	genmol	genmol	PROPN
hjic-110	108	5	software	software	PROPN
hjic-110	108	6	)	)	PUNCT
hjic-110	108	7	revealed	reveal	VERB
hjic-110	108	8	a	a	DET
hjic-110	108	9	potential	potential	ADJ
hjic-110	108	10	hydrogen	hydrogen	NOUN
hjic-110	108	11	bonding	bonding	NOUN
hjic-110	108	12	between	between	ADP
hjic-110	108	13	carboxylic	carboxylic	ADJ
hjic-110	109	1	oh	oh	INTJ
hjic-110	109	2	and	and	CCONJ
hjic-110	109	3	the	the	DET
hjic-110	109	4	methoxy	methoxy	ADJ
hjic-110	109	5	oxygen	oxygen	NOUN
hjic-110	109	6	(	(	PUNCT
hjic-110	109	7	internal	internal	ADJ
hjic-110	109	8	rapport	rapport	NOUN
hjic-110	109	9	)	)	PUNCT
hjic-110	109	10	.	.	PUNCT
hjic-110	110	1	owing	owe	VERB
hjic-110	110	2	to	to	ADP
hjic-110	110	3	this	this	DET
hjic-110	110	4	hydrogen	hydrogen	NOUN
hjic-110	110	5	bonding	bonding	NOUN
hjic-110	110	6	effect	effect	NOUN
hjic-110	110	7	,	,	PUNCT
hjic-110	110	8	the	the	DET
hjic-110	110	9	crystal	crystal	NOUN
hjic-110	110	10	growth	growth	NOUN
hjic-110	110	11	of	of	ADP
hjic-110	110	12	oxeglitazar	oxeglitazar	NOUN
hjic-110	110	13	is	be	AUX
hjic-110	110	14	preferred	prefer	VERB
hjic-110	110	15	in	in	ADP
hjic-110	110	16	one	one	NUM
hjic-110	110	17	crystallographic	crystallographic	ADJ
hjic-110	110	18	direction	direction	NOUN
hjic-110	110	19	resulting	result	VERB
hjic-110	110	20	in	in	ADP
hjic-110	110	21	acicular	acicular	ADJ
hjic-110	110	22	crystals	crystal	NOUN
hjic-110	110	23	.	.	PUNCT
hjic-110	111	1	this	this	DET
hjic-110	111	2	habit	habit	NOUN
hjic-110	111	3	was	be	AUX
hjic-110	111	4	found	find	VERB
hjic-110	111	5	undesirable	undesirable	ADJ
hjic-110	111	6	because	because	SCONJ
hjic-110	111	7	of	of	ADP
hjic-110	111	8	its	its	PRON
hjic-110	111	9	poor	poor	ADJ
hjic-110	111	10	flow	flow	NOUN
hjic-110	111	11	properties	property	NOUN
hjic-110	111	12	.	.	PUNCT
hjic-110	112	1	sas	sas	PROPN
hjic-110	112	2	prepared	prepared	PROPN
hjic-110	112	3	coprecipitates	coprecipitate	NOUN
hjic-110	112	4	formed	form	VERB
hjic-110	112	5	a	a	DET
hjic-110	112	6	thick	thick	ADJ
hjic-110	112	7	cottony	cottony	NOUN
hjic-110	112	8	layer	layer	NOUN
hjic-110	112	9	on	on	ADP
hjic-110	112	10	vessel	vessel	NOUN
hjic-110	112	11	wall	wall	PROPN
hjic-110	112	12	.	.	PUNCT
hjic-110	113	1	oxeglitazar	oxeglitazar	PROPN
hjic-110	113	2	/	/	SYM
hjic-110	113	3	poloxamer	poloxamer	NOUN
hjic-110	113	4	407	407	NUM
hjic-110	113	5	powder	powder	NOUN
hjic-110	113	6	consisted	consist	VERB
hjic-110	113	7	of	of	ADP
hjic-110	113	8	aggregated	aggregate	VERB
hjic-110	113	9	acicular	acicular	ADJ
hjic-110	113	10	particles	particle	NOUN
hjic-110	113	11	ranging	range	VERB
hjic-110	113	12	from	from	ADP
hjic-110	113	13	0.5	0.5	NUM
hjic-110	113	14	to	to	PART
hjic-110	113	15	1.5	1.5	NUM
hjic-110	113	16	mm	mm	NOUN
hjic-110	113	17	in	in	ADP
hjic-110	113	18	length	length	NOUN
hjic-110	113	19	(	(	PUNCT
hjic-110	113	20	fig	fig	NOUN
hjic-110	113	21	.	.	PUNCT
hjic-110	114	1	3b	3b	NUM
hjic-110	114	2	)	)	PUNCT
hjic-110	114	3	.	.	PUNCT
hjic-110	115	1	in	in	ADP
hjic-110	115	2	contrast	contrast	NOUN
hjic-110	115	3	,	,	PUNCT
hjic-110	115	4	coprecipitation	coprecipitation	NOUN
hjic-110	115	5	of	of	ADP
hjic-110	115	6	drug	drug	NOUN
hjic-110	115	7	and	and	CCONJ
hjic-110	115	8	pvp	pvp	PROPN
hjic-110	115	9	k17	k17	PROPN
hjic-110	115	10	resulted	result	VERB
hjic-110	115	11	in	in	ADP
hjic-110	115	12	aggregated	aggregated	ADJ
hjic-110	115	13	tabular	tabular	NOUN
hjic-110	115	14	particles	particle	NOUN
hjic-110	115	15	with	with	ADP
hjic-110	115	16	a	a	DET
hjic-110	115	17	mean	mean	ADJ
hjic-110	115	18	diameter	diameter	NOUN
hjic-110	115	19	of	of	ADP
hjic-110	115	20	less	less	ADJ
hjic-110	115	21	than	than	ADP
hjic-110	115	22	200	200	NUM
hjic-110	115	23	μm	μm	ADJ
hjic-110	115	24	and	and	CCONJ
hjic-110	115	25	a	a	DET
hjic-110	115	26	thickness	thickness	NOUN
hjic-110	115	27	of	of	ADP
hjic-110	115	28	a	a	DET
hjic-110	115	29	few	few	ADJ
hjic-110	115	30	micrometers	micrometer	NOUN
hjic-110	115	31	(	(	PUNCT
hjic-110	115	32	fig	fig	NOUN
hjic-110	115	33	.	.	PUNCT
hjic-110	116	1	3c	3c	NUM
hjic-110	116	2	)	)	PUNCT
hjic-110	116	3	.	.	PUNCT
hjic-110	117	1	aggregates	aggregate	NOUN
hjic-110	117	2	of	of	ADP
hjic-110	117	3	rod	rod	NOUN
hjic-110	117	4	-	-	PUNCT
hjic-110	117	5	like	like	ADJ
hjic-110	117	6	crystals	crystal	NOUN
hjic-110	117	7	and	and	CCONJ
hjic-110	117	8	irregular	irregular	ADJ
hjic-110	117	9	particles	particle	NOUN
hjic-110	117	10	were	be	AUX
hjic-110	117	11	observed	observe	VERB
hjic-110	117	12	for	for	ADP
hjic-110	117	13	oxeglitazar	oxeglitazar	NOUN
hjic-110	117	14	/	/	SYM
hjic-110	117	15	poloxamer	poloxamer	NOUN
hjic-110	117	16	407	407	NUM
hjic-110	117	17	coevaporate	coevaporate	NOUN
hjic-110	117	18	(	(	PUNCT
hjic-110	117	19	fig	fig	NOUN
hjic-110	117	20	.	.	PUNCT
hjic-110	118	1	3d	3d	NUM
hjic-110	118	2	)	)	PUNCT
hjic-110	118	3	.	.	PUNCT
hjic-110	119	1	unlike	unlike	ADP
hjic-110	119	2	the	the	DET
hjic-110	119	3	above	above	ADJ
hjic-110	119	4	mentioned	mention	VERB
hjic-110	119	5	formulations	formulation	NOUN
hjic-110	119	6	,	,	PUNCT
hjic-110	119	7	pvp	pvp	PROPN
hjic-110	119	8	has	have	AUX
hjic-110	119	9	precipitated	precipitate	VERB
hjic-110	119	10	as	as	ADP
hjic-110	119	11	a	a	DET
hjic-110	119	12	film	film	NOUN
hjic-110	119	13	rather	rather	ADV
hjic-110	119	14	than	than	ADP
hjic-110	119	15	particulate	particulate	NOUN
hjic-110	119	16	powder	powder	NOUN
hjic-110	119	17	(	(	PUNCT
hjic-110	119	18	fig	fig	NOUN
hjic-110	119	19	.	.	PUNCT
hjic-110	120	1	3e	3e	NUM
hjic-110	120	2	)	)	PUNCT
hjic-110	120	3	.	.	PUNCT
hjic-110	121	1	fig	fig	NOUN
hjic-110	121	2	.	.	PUNCT
hjic-110	122	1	3	3	X
hjic-110	122	2	.	.	X
hjic-110	122	3	scanning	scan	VERB
hjic-110	122	4	electron	electron	NOUN
hjic-110	122	5	micrographs	micrograph	NOUN
hjic-110	122	6	of	of	ADP
hjic-110	122	7	raw	raw	ADJ
hjic-110	122	8	oxeglitazar	oxeglitazar	NOUN
hjic-110	122	9	(	(	PUNCT
hjic-110	122	10	a	a	X
hjic-110	122	11	)	)	PUNCT
hjic-110	122	12	,	,	PUNCT
hjic-110	122	13	sas	sa	VERB
hjic-110	122	14	oxeglitazar	oxeglitazar	PROPN
hjic-110	122	15	/	/	SYM
hjic-110	122	16	poloxamer	poloxamer	NOUN
hjic-110	122	17	407	407	NUM
hjic-110	122	18	(	(	PUNCT
hjic-110	122	19	b	b	NOUN
hjic-110	122	20	)	)	PUNCT
hjic-110	122	21	,	,	PUNCT
hjic-110	122	22	sas	sa	VERB
hjic-110	122	23	oxeglitazar	oxeglitazar	PROPN
hjic-110	122	24	/	/	SYM
hjic-110	122	25	pvp	pvp	PROPN
hjic-110	122	26	k17	k17	PROPN
hjic-110	122	27	(	(	PUNCT
hjic-110	122	28	c	c	NOUN
hjic-110	122	29	)	)	PUNCT
hjic-110	122	30	,	,	PUNCT
hjic-110	122	31	coe	coe	PROPN
hjic-110	122	32	oxeglitazar/	oxeglitazar/	PROPN
hjic-110	122	33	poloxamer	poloxamer	NOUN
hjic-110	122	34	407	407	NUM
hjic-110	122	35	(	(	PUNCT
hjic-110	122	36	d	d	NOUN
hjic-110	122	37	)	)	PUNCT
hjic-110	122	38	,	,	PUNCT
hjic-110	122	39	coe	coe	PROPN
hjic-110	122	40	oxeglitazar	oxeglitazar	PROPN
hjic-110	122	41	/	/	SYM
hjic-110	122	42	pvp	pvp	PROPN
hjic-110	122	43	k17	k17	PROPN
hjic-110	122	44	(	(	PUNCT
hjic-110	122	45	e	e	NOUN
hjic-110	122	46	)	)	PUNCT
hjic-110	122	47	.	.	PUNCT
hjic-110	123	1	45	45	NUM
hjic-110	123	2	crystallinity	crystallinity	NOUN
hjic-110	123	3	and	and	CCONJ
hjic-110	123	4	polymorphic	polymorphic	ADJ
hjic-110	123	5	purity	purity	NOUN
hjic-110	123	6	xrd	xrd	NOUN
hjic-110	123	7	patterns	pattern	NOUN
hjic-110	123	8	of	of	ADP
hjic-110	123	9	raw	raw	ADJ
hjic-110	123	10	drug	drug	NOUN
hjic-110	123	11	,	,	PUNCT
hjic-110	123	12	excipients	excipient	NOUN
hjic-110	123	13	,	,	PUNCT
hjic-110	123	14	coprecipitates	coprecipitate	NOUN
hjic-110	123	15	and	and	CCONJ
hjic-110	123	16	coevaporates	coevaporate	NOUN
hjic-110	123	17	are	be	AUX
hjic-110	123	18	shown	show	VERB
hjic-110	123	19	in	in	ADP
hjic-110	123	20	fig	fig	NOUN
hjic-110	123	21	.	.	PUNCT
hjic-110	124	1	4	4	NUM
hjic-110	124	2	and	and	CCONJ
hjic-110	124	3	fig	fig	NOUN
hjic-110	124	4	.	.	PUNCT
hjic-110	125	1	5	5	NUM
hjic-110	125	2	.	.	X
hjic-110	125	3	oxeglitazar	oxeglitazar	NOUN
hjic-110	125	4	and	and	CCONJ
hjic-110	125	5	poloxamer	poloxamer	PROPN
hjic-110	125	6	407	407	NUM
hjic-110	125	7	are	be	AUX
hjic-110	125	8	crystalline	crystalline	NOUN
hjic-110	125	9	compounds	compound	NOUN
hjic-110	125	10	with	with	ADP
hjic-110	125	11	well	well	ADV
hjic-110	125	12	-	-	PUNCT
hjic-110	125	13	defined	define	VERB
hjic-110	125	14	peaks	peak	NOUN
hjic-110	125	15	while	while	SCONJ
hjic-110	125	16	pvp	pvp	PROPN
hjic-110	125	17	k17	k17	PROPN
hjic-110	125	18	is	be	AUX
hjic-110	125	19	amorphous	amorphous	ADJ
hjic-110	125	20	and	and	CCONJ
hjic-110	125	21	shows	show	VERB
hjic-110	125	22	no	no	DET
hjic-110	125	23	diffraction	diffraction	NOUN
hjic-110	125	24	peak	peak	NOUN
hjic-110	125	25	.	.	PUNCT
hjic-110	126	1	although	although	SCONJ
hjic-110	126	2	crystalline	crystalline	ADJ
hjic-110	126	3	drug	drug	NOUN
hjic-110	126	4	was	be	AUX
hjic-110	126	5	detectable	detectable	ADJ
hjic-110	126	6	in	in	ADP
hjic-110	126	7	all	all	DET
hjic-110	126	8	formulations	formulation	NOUN
hjic-110	126	9	,	,	PUNCT
hjic-110	126	10	considerably	considerably	ADV
hjic-110	126	11	lower	low	ADJ
hjic-110	126	12	peak	peak	NOUN
hjic-110	126	13	intensities	intensity	NOUN
hjic-110	126	14	were	be	AUX
hjic-110	126	15	observed	observe	VERB
hjic-110	126	16	suggesting	suggest	VERB
hjic-110	126	17	that	that	SCONJ
hjic-110	126	18	semi	semi	ADJ
hjic-110	126	19	-	-	ADJ
hjic-110	126	20	crystalline	crystalline	ADJ
hjic-110	126	21	solid	solid	ADJ
hjic-110	126	22	dispersions	dispersion	NOUN
hjic-110	126	23	were	be	AUX
hjic-110	126	24	obtained	obtain	VERB
hjic-110	126	25	in	in	ADP
hjic-110	126	26	both	both	DET
hjic-110	126	27	techniques	technique	NOUN
hjic-110	126	28	.	.	PUNCT
hjic-110	127	1	the	the	DET
hjic-110	127	2	highest	high	ADJ
hjic-110	127	3	amorphous	amorphous	ADJ
hjic-110	127	4	content	content	NOUN
hjic-110	127	5	was	be	AUX
hjic-110	127	6	measured	measure	VERB
hjic-110	127	7	in	in	ADP
hjic-110	127	8	coe	coe	PROPN
hjic-110	127	9	oxeglitazar	oxeglitazar	PROPN
hjic-110	127	10	/	/	SYM
hjic-110	127	11	pvp	pvp	PROPN
hjic-110	127	12	k17	k17	PROPN
hjic-110	127	13	followed	follow	VERB
hjic-110	127	14	by	by	ADP
hjic-110	127	15	sas	sas	PROPN
hjic-110	127	16	oxeglitazar	oxeglitazar	PROPN
hjic-110	127	17	/	/	SYM
hjic-110	127	18	pvp	pvp	PROPN
hjic-110	127	19	k17	k17	PROPN
hjic-110	127	20	,	,	PUNCT
hjic-110	127	21	coe	coe	PROPN
hjic-110	127	22	oxeglitazar	oxeglitazar	PROPN
hjic-110	127	23	/	/	SYM
hjic-110	127	24	poloxamer	poloxamer	NOUN
hjic-110	127	25	407	407	NUM
hjic-110	127	26	and	and	CCONJ
hjic-110	127	27	sas	sa	VERB
hjic-110	127	28	oxeglitazar	oxeglitazar	PROPN
hjic-110	127	29	/	/	SYM
hjic-110	127	30	poloxamer	poloxamer	NOUN
hjic-110	127	31	407	407	NUM
hjic-110	127	32	.	.	PUNCT
hjic-110	128	1	preliminary	preliminary	ADJ
hjic-110	128	2	xrd	xrd	NOUN
hjic-110	128	3	and	and	CCONJ
hjic-110	128	4	differential	differential	NOUN
hjic-110	128	5	scanning	scan	VERB
hjic-110	128	6	calorimetric	calorimetric	ADJ
hjic-110	128	7	studies	study	NOUN
hjic-110	128	8	(	(	PUNCT
hjic-110	128	9	data	datum	NOUN
hjic-110	128	10	not	not	PART
hjic-110	128	11	shown	show	VERB
hjic-110	128	12	)	)	PUNCT
hjic-110	128	13	revealed	reveal	VERB
hjic-110	128	14	that	that	SCONJ
hjic-110	128	15	oxeglitazar	oxeglitazar	NOUN
hjic-110	128	16	has	have	VERB
hjic-110	128	17	two	two	NUM
hjic-110	128	18	polymorphic	polymorphic	ADJ
hjic-110	128	19	forms	form	NOUN
hjic-110	128	20	of	of	ADP
hjic-110	128	21	which	which	PRON
hjic-110	128	22	the	the	DET
hjic-110	128	23	higher	high	ADJ
hjic-110	128	24	melting	melting	NOUN
hjic-110	128	25	form	form	NOUN
hjic-110	128	26	(	(	PUNCT
hjic-110	128	27	a	a	X
hjic-110	128	28	)	)	PUNCT
hjic-110	128	29	is	be	AUX
hjic-110	128	30	the	the	DET
hjic-110	128	31	thermodynamically	thermodynamically	ADV
hjic-110	128	32	stable	stable	ADJ
hjic-110	128	33	one	one	NOUN
hjic-110	128	34	at	at	ADP
hjic-110	128	35	all	all	DET
hjic-110	128	36	temperatures	temperature	NOUN
hjic-110	128	37	(	(	PUNCT
hjic-110	128	38	monotropic	monotropic	NOUN
hjic-110	128	39	system	system	NOUN
hjic-110	128	40	)	)	PUNCT
hjic-110	128	41	.	.	PUNCT
hjic-110	129	1	however	however	ADV
hjic-110	129	2	,	,	PUNCT
hjic-110	129	3	the	the	DET
hjic-110	129	4	metastable	metastable	ADJ
hjic-110	129	5	form	form	NOUN
hjic-110	129	6	was	be	AUX
hjic-110	129	7	not	not	PART
hjic-110	129	8	detectable	detectable	ADJ
hjic-110	129	9	in	in	ADP
hjic-110	129	10	any	any	DET
hjic-110	129	11	formulation	formulation	NOUN
hjic-110	129	12	.	.	PUNCT
hjic-110	130	1	fig	fig	NOUN
hjic-110	130	2	.	.	PUNCT
hjic-110	131	1	4	4	X
hjic-110	131	2	.	.	X
hjic-110	131	3	xrd	xrd	PROPN
hjic-110	131	4	patterns	pattern	NOUN
hjic-110	131	5	of	of	ADP
hjic-110	131	6	raw	raw	ADJ
hjic-110	131	7	drug	drug	NOUN
hjic-110	131	8	(	(	PUNCT
hjic-110	131	9	a	a	X
hjic-110	131	10	)	)	PUNCT
hjic-110	131	11	,	,	PUNCT
hjic-110	131	12	sas	sa	VERB
hjic-110	131	13	oxeglitazar	oxeglitazar	PROPN
hjic-110	131	14	/	/	SYM
hjic-110	131	15	poloxamer	poloxamer	NOUN
hjic-110	131	16	407	407	NUM
hjic-110	131	17	(	(	PUNCT
hjic-110	131	18	b	b	NOUN
hjic-110	131	19	)	)	PUNCT
hjic-110	131	20	,	,	PUNCT
hjic-110	131	21	poloxamer	poloxamer	NOUN
hjic-110	131	22	407	407	NUM
hjic-110	131	23	(	(	PUNCT
hjic-110	131	24	c	c	NOUN
hjic-110	131	25	)	)	PUNCT
hjic-110	131	26	,	,	PUNCT
hjic-110	131	27	sas	sa	VERB
hjic-110	131	28	oxeglitazar	oxeglitazar	PROPN
hjic-110	131	29	/	/	SYM
hjic-110	131	30	pvp	pvp	PROPN
hjic-110	131	31	k17	k17	PROPN
hjic-110	131	32	(	(	PUNCT
hjic-110	131	33	d	d	PROPN
hjic-110	131	34	)	)	PUNCT
hjic-110	131	35	,	,	PUNCT
hjic-110	131	36	pvp	pvp	PROPN
hjic-110	131	37	k17	k17	PROPN
hjic-110	131	38	(	(	PUNCT
hjic-110	131	39	e	e	NOUN
hjic-110	131	40	)	)	PUNCT
hjic-110	131	41	.	.	PUNCT
hjic-110	132	1	fig	fig	NOUN
hjic-110	132	2	.	.	PUNCT
hjic-110	133	1	5	5	NUM
hjic-110	133	2	.	.	X
hjic-110	133	3	xrd	xrd	PROPN
hjic-110	133	4	patterns	pattern	NOUN
hjic-110	133	5	of	of	ADP
hjic-110	133	6	raw	raw	ADJ
hjic-110	133	7	drug	drug	NOUN
hjic-110	133	8	(	(	PUNCT
hjic-110	133	9	a	a	X
hjic-110	133	10	)	)	PUNCT
hjic-110	133	11	,	,	PUNCT
hjic-110	133	12	coe	coe	PROPN
hjic-110	133	13	oxeglitazar	oxeglitazar	PROPN
hjic-110	133	14	/	/	SYM
hjic-110	133	15	poloxamer	poloxamer	NOUN
hjic-110	133	16	407	407	NUM
hjic-110	133	17	(	(	PUNCT
hjic-110	133	18	b	b	NOUN
hjic-110	133	19	)	)	PUNCT
hjic-110	133	20	,	,	PUNCT
hjic-110	133	21	poloxamer	poloxamer	NOUN
hjic-110	133	22	407	407	NUM
hjic-110	133	23	(	(	PUNCT
hjic-110	133	24	c	c	NOUN
hjic-110	133	25	)	)	PUNCT
hjic-110	133	26	,	,	PUNCT
hjic-110	133	27	coe	coe	PROPN
hjic-110	133	28	oxeglitazar	oxeglitazar	PROPN
hjic-110	133	29	/	/	SYM
hjic-110	133	30	pvp	pvp	PROPN
hjic-110	133	31	k17	k17	PROPN
hjic-110	133	32	(	(	PUNCT
hjic-110	133	33	d	d	PROPN
hjic-110	133	34	)	)	PUNCT
hjic-110	133	35	,	,	PUNCT
hjic-110	133	36	pvp	pvp	PROPN
hjic-110	133	37	k17	k17	PROPN
hjic-110	133	38	(	(	PUNCT
hjic-110	133	39	e	e	NOUN
hjic-110	133	40	)	)	PUNCT
hjic-110	133	41	.	.	PUNCT
hjic-110	134	1	hydrogen	hydrogen	NOUN
hjic-110	134	2	bonding	bonding	NOUN
hjic-110	134	3	interactions	interaction	NOUN
hjic-110	134	4	ftir	ftir	NOUN
hjic-110	134	5	is	be	AUX
hjic-110	134	6	probably	probably	ADV
hjic-110	134	7	the	the	DET
hjic-110	134	8	most	most	ADV
hjic-110	134	9	widely	widely	ADV
hjic-110	134	10	used	use	VERB
hjic-110	134	11	analytical	analytical	ADJ
hjic-110	134	12	method	method	NOUN
hjic-110	134	13	to	to	PART
hjic-110	134	14	detect	detect	VERB
hjic-110	134	15	hydrogen	hydrogen	NOUN
hjic-110	134	16	bonding	bonding	NOUN
hjic-110	134	17	in	in	ADP
hjic-110	134	18	drug	drug	NOUN
hjic-110	134	19	-	-	PUNCT
hjic-110	134	20	carrier	carrier	NOUN
hjic-110	134	21	solid	solid	ADJ
hjic-110	134	22	dispersions	dispersion	NOUN
hjic-110	134	23	.	.	PUNCT
hjic-110	135	1	it	it	PRON
hjic-110	135	2	is	be	AUX
hjic-110	135	3	known	know	VERB
hjic-110	135	4	,	,	PUNCT
hjic-110	135	5	that	that	SCONJ
hjic-110	135	6	absorption	absorption	NOUN
hjic-110	135	7	bands	band	NOUN
hjic-110	135	8	of	of	ADP
hjic-110	135	9	the	the	DET
hjic-110	135	10	groups	group	NOUN
hjic-110	135	11	,	,	PUNCT
hjic-110	135	12	involved	involve	VERB
hjic-110	135	13	in	in	ADP
hjic-110	135	14	hydrogen	hydrogen	NOUN
hjic-110	135	15	bonding	bonding	NOUN
hjic-110	135	16	,	,	PUNCT
hjic-110	135	17	shift	shift	NOUN
hjic-110	135	18	to	to	ADP
hjic-110	135	19	lower	low	ADJ
hjic-110	135	20	wave	wave	NOUN
hjic-110	135	21	numbers	number	NOUN
hjic-110	135	22	[	[	X
hjic-110	135	23	11	11	NUM
hjic-110	135	24	]	]	PUNCT
hjic-110	135	25	.	.	PUNCT
hjic-110	136	1	however	however	ADV
hjic-110	136	2	,	,	PUNCT
hjic-110	136	3	the	the	DET
hjic-110	136	4	new	new	ADJ
hjic-110	136	5	band	band	NOUN
hjic-110	136	6	appears	appear	VERB
hjic-110	136	7	only	only	ADV
hjic-110	136	8	when	when	SCONJ
hjic-110	136	9	the	the	DET
hjic-110	136	10	ratio	ratio	NOUN
hjic-110	136	11	of	of	ADP
hjic-110	136	12	bonded	bond	VERB
hjic-110	136	13	to	to	ADP
hjic-110	136	14	non	non	ADJ
hjic-110	136	15	-	-	ADJ
hjic-110	136	16	bonded	bond	VERB
hjic-110	136	17	group	group	NOUN
hjic-110	136	18	is	be	AUX
hjic-110	136	19	high	high	ADJ
hjic-110	136	20	enough	enough	ADV
hjic-110	136	21	.	.	PUNCT
hjic-110	137	1	when	when	SCONJ
hjic-110	137	2	non	non	ADJ
hjic-110	137	3	-	-	ADJ
hjic-110	137	4	bonded	bond	VERB
hjic-110	137	5	groups	group	NOUN
hjic-110	137	6	dominate	dominate	VERB
hjic-110	137	7	over	over	ADP
hjic-110	137	8	hydrogen	hydrogen	NOUN
hjic-110	137	9	-	-	PUNCT
hjic-110	137	10	bonded	bond	VERB
hjic-110	137	11	ones	one	NOUN
hjic-110	137	12	,	,	PUNCT
hjic-110	137	13	only	only	ADV
hjic-110	137	14	a	a	DET
hjic-110	137	15	slight	slight	ADJ
hjic-110	137	16	broadening	broadening	NOUN
hjic-110	137	17	is	be	AUX
hjic-110	137	18	observed	observe	VERB
hjic-110	137	19	due	due	ADP
hjic-110	137	20	to	to	ADP
hjic-110	137	21	the	the	DET
hjic-110	137	22	superposition	superposition	NOUN
hjic-110	137	23	of	of	ADP
hjic-110	137	24	the	the	DET
hjic-110	137	25	two	two	NUM
hjic-110	137	26	bands	band	NOUN
hjic-110	137	27	.	.	PUNCT
hjic-110	138	1	oxeglitazar	oxeglitazar	NOUN
hjic-110	138	2	contains	contain	VERB
hjic-110	138	3	one	one	NUM
hjic-110	138	4	hydrogen	hydrogen	NOUN
hjic-110	138	5	donor	donor	NOUN
hjic-110	138	6	(	(	PUNCT
hjic-110	138	7	-oh	-oh	NOUN
hjic-110	138	8	)	)	PUNCT
hjic-110	138	9	and	and	CCONJ
hjic-110	138	10	three	three	NUM
hjic-110	138	11	hydrogen	hydrogen	NOUN
hjic-110	138	12	acceptor	acceptor	NOUN
hjic-110	138	13	groups	group	NOUN
hjic-110	138	14	(	(	PUNCT
hjic-110	138	15	-c	-c	PUNCT
hjic-110	138	16	=	=	SYM
hjic-110	138	17	o	o	NOUN
hjic-110	138	18	,	,	PUNCT
hjic-110	138	19	aryl	aryl	NOUN
hjic-110	138	20	-	-	PUNCT
hjic-110	138	21	o	o	NOUN
hjic-110	138	22	-	-	NOUN
hjic-110	138	23	ch3	ch3	ADJ
hjic-110	138	24	and	and	CCONJ
hjic-110	138	25	aryl	aryl	PROPN
hjic-110	138	26	-	-	PUNCT
hjic-110	138	27	o	o	NOUN
hjic-110	138	28	-	-	PUNCT
hjic-110	138	29	r	r	NOUN
hjic-110	138	30	)	)	PUNCT
hjic-110	138	31	.	.	PUNCT
hjic-110	139	1	the	the	DET
hjic-110	139	2	characteristic	characteristic	ADJ
hjic-110	139	3	absorption	absorption	NOUN
hjic-110	139	4	bands	band	NOUN
hjic-110	139	5	of	of	ADP
hjic-110	139	6	these	these	DET
hjic-110	139	7	groups	group	NOUN
hjic-110	139	8	are	be	AUX
hjic-110	139	9	νc	νc	X
hjic-110	139	10	=	=	X
hjic-110	139	11	o	o	NOUN
hjic-110	139	12	at	at	ADP
hjic-110	139	13	1681	1681	NUM
hjic-110	139	14	cm-1	cm-1	PROPN
hjic-110	139	15	,	,	PUNCT
hjic-110	139	16	νo	νo	NOUN
hjic-110	139	17	-	-	NOUN
hjic-110	139	18	h	h	NOUN
hjic-110	139	19	in	in	ADP
hjic-110	139	20	the	the	DET
hjic-110	139	21	range	range	NOUN
hjic-110	139	22	of	of	ADP
hjic-110	139	23	2500	2500	NUM
hjic-110	139	24	-	-	SYM
hjic-110	139	25	3700	3700	NUM
hjic-110	139	26	cm-1	cm-1	X
hjic-110	139	27	(	(	PUNCT
hjic-110	139	28	carboxylic	carboxylic	ADJ
hjic-110	139	29	group	group	NOUN
hjic-110	139	30	)	)	PUNCT
hjic-110	139	31	,	,	PUNCT
hjic-110	139	32	νasc	νasc	PROPN
hjic-110	139	33	-	-	NOUN
hjic-110	139	34	o	o	NOUN
hjic-110	139	35	at	at	ADP
hjic-110	139	36	12711212	12711212	NUM
hjic-110	139	37	cm-1	cm-1	NOUN
hjic-110	139	38	and	and	CCONJ
hjic-110	139	39	νsc	νsc	PROPN
hjic-110	139	40	-	-	PROPN
hjic-110	139	41	o	o	PROPN
hjic-110	139	42	at	at	ADP
hjic-110	139	43	1047	1047	NUM
hjic-110	139	44	-	-	SYM
hjic-110	139	45	1029	1029	NUM
hjic-110	139	46	cm-1	cm-1	NOUN
hjic-110	139	47	of	of	ADP
hjic-110	139	48	methoxy	methoxy	ADJ
hjic-110	139	49	and	and	CCONJ
hjic-110	139	50	cyclic	cyclic	ADJ
hjic-110	139	51	ether	ether	NOUN
hjic-110	139	52	group	group	NOUN
hjic-110	139	53	(	(	PUNCT
hjic-110	139	54	fig	fig	NOUN
hjic-110	139	55	.	.	PUNCT
hjic-110	139	56	6a	6a	NOUN
hjic-110	139	57	)	)	PUNCT
hjic-110	139	58	.	.	PUNCT
hjic-110	140	1	although	although	SCONJ
hjic-110	140	2	the	the	DET
hjic-110	140	3	stretching	stretch	VERB
hjic-110	140	4	vibration	vibration	NOUN
hjic-110	140	5	of	of	ADP
hjic-110	140	6	oh	oh	INTJ
hjic-110	140	7	gives	give	VERB
hjic-110	140	8	a	a	DET
hjic-110	140	9	broad	broad	ADJ
hjic-110	140	10	and	and	CCONJ
hjic-110	140	11	intense	intense	ADJ
hjic-110	140	12	band	band	NOUN
hjic-110	140	13	it	it	PRON
hjic-110	140	14	was	be	AUX
hjic-110	140	15	not	not	PART
hjic-110	140	16	considered	consider	VERB
hjic-110	140	17	because	because	SCONJ
hjic-110	140	18	of	of	ADP
hjic-110	140	19	the	the	DET
hjic-110	140	20	water	water	NOUN
hjic-110	140	21	residues	residue	NOUN
hjic-110	140	22	[	[	X
hjic-110	140	23	40	40	NUM
hjic-110	140	24	]	]	PUNCT
hjic-110	140	25	.	.	PUNCT
hjic-110	141	1	the	the	DET
hjic-110	141	2	position	position	NOUN
hjic-110	141	3	of	of	ADP
hjic-110	141	4	νc	νc	NOUN
hjic-110	141	5	=	=	NOUN
hjic-110	141	6	o	o	NOUN
hjic-110	141	7	band	band	NOUN
hjic-110	141	8	was	be	AUX
hjic-110	141	9	below	below	ADP
hjic-110	141	10	1700	1700	NUM
hjic-110	141	11	cm-1	cm-1	NOUN
hjic-110	141	12	due	due	ADP
hjic-110	141	13	to	to	ADP
hjic-110	141	14	the	the	DET
hjic-110	141	15	conjugation	conjugation	NOUN
hjic-110	141	16	with	with	ADP
hjic-110	141	17	double	double	ADJ
hjic-110	141	18	bounds	bound	NOUN
hjic-110	141	19	and	and	CCONJ
hjic-110	141	20	aromatic	aromatic	ADJ
hjic-110	141	21	ring	ring	NOUN
hjic-110	141	22	[	[	X
hjic-110	141	23	41	41	NUM
hjic-110	141	24	]	]	PUNCT
hjic-110	141	25	.	.	PUNCT
hjic-110	142	1	likewise	likewise	ADV
hjic-110	142	2	,	,	PUNCT
hjic-110	142	3	a	a	DET
hjic-110	142	4	broad	broad	ADJ
hjic-110	142	5	well	well	ADV
hjic-110	142	6	defined	define	VERB
hjic-110	142	7	band	band	NOUN
hjic-110	142	8	was	be	AUX
hjic-110	142	9	observed	observe	VERB
hjic-110	142	10	in	in	ADP
hjic-110	142	11	the	the	DET
hjic-110	142	12	spectrum	spectrum	NOUN
hjic-110	142	13	of	of	ADP
hjic-110	142	14	pvp	pvp	PROPN
hjic-110	142	15	k17	k17	PROPN
hjic-110	142	16	at	at	ADP
hjic-110	142	17	1672	1672	NUM
hjic-110	142	18	cm-1	cm-1	NOUN
hjic-110	142	19	assigned	assign	VERB
hjic-110	142	20	to	to	ADP
hjic-110	142	21	the	the	DET
hjic-110	142	22	carbonyl	carbonyl	NOUN
hjic-110	142	23	stretching	stretch	VERB
hjic-110	142	24	vibration	vibration	NOUN
hjic-110	142	25	(	(	PUNCT
hjic-110	142	26	fig	fig	NOUN
hjic-110	142	27	.	.	PUNCT
hjic-110	143	1	6b	6b	NUM
hjic-110	143	2	)	)	PUNCT
hjic-110	143	3	.	.	PUNCT
hjic-110	144	1	each	each	DET
hjic-110	144	2	pyrrole	pyrrole	NOUN
hjic-110	144	3	ring	ring	NOUN
hjic-110	144	4	of	of	ADP
hjic-110	144	5	the	the	DET
hjic-110	144	6	pvp	pvp	NOUN
hjic-110	144	7	polymer	polymer	NOUN
hjic-110	144	8	contains	contain	VERB
hjic-110	144	9	two	two	NUM
hjic-110	144	10	hydrogen	hydrogen	NOUN
hjic-110	144	11	acceptor	acceptor	NOUN
hjic-110	144	12	groups	group	NOUN
hjic-110	144	13	:	:	PUNCT
hjic-110	144	14	a	a	DET
hjic-110	144	15	carbonyl	carbonyl	NOUN
hjic-110	144	16	group	group	NOUN
hjic-110	144	17	and	and	CCONJ
hjic-110	144	18	a	a	DET
hjic-110	144	19	tertiary	tertiary	ADJ
hjic-110	144	20	amine	amine	NOUN
hjic-110	144	21	.	.	PUNCT
hjic-110	145	1	however	however	ADV
hjic-110	145	2	,	,	PUNCT
hjic-110	145	3	this	this	DET
hjic-110	145	4	latter	latter	ADJ
hjic-110	145	5	is	be	AUX
hjic-110	145	6	not	not	PART
hjic-110	145	7	favored	favor	VERB
hjic-110	145	8	in	in	ADP
hjic-110	145	9	hydrogen	hydrogen	NOUN
hjic-110	145	10	bonding	bonding	NOUN
hjic-110	145	11	due	due	ADP
hjic-110	145	12	to	to	ADP
hjic-110	145	13	a	a	DET
hjic-110	145	14	steric	steric	ADJ
hjic-110	145	15	hindrance	hindrance	NOUN
hjic-110	145	16	[	[	X
hjic-110	145	17	11,42	11,42	NOUN
hjic-110	145	18	]	]	PUNCT
hjic-110	145	19	.	.	PUNCT
hjic-110	146	1	the	the	DET
hjic-110	146	2	ftir	ftir	PROPN
hjic-110	146	3	spectrum	spectrum	NOUN
hjic-110	146	4	of	of	ADP
hjic-110	146	5	the	the	DET
hjic-110	146	6	physical	physical	ADJ
hjic-110	146	7	mixture	mixture	NOUN
hjic-110	146	8	revealed	reveal	VERB
hjic-110	146	9	no	no	DET
hjic-110	146	10	considerable	considerable	ADJ
hjic-110	146	11	interaction	interaction	NOUN
hjic-110	146	12	between	between	ADP
hjic-110	146	13	the	the	DET
hjic-110	146	14	pharmaceutical	pharmaceutical	NOUN
hjic-110	146	15	ingredients	ingredient	NOUN
hjic-110	146	16	.	.	PUNCT
hjic-110	147	1	the	the	DET
hjic-110	147	2	spectrum	spectrum	NOUN
hjic-110	147	3	shown	show	VERB
hjic-110	147	4	in	in	ADP
hjic-110	147	5	fig	fig	NOUN
hjic-110	147	6	.	.	PUNCT
hjic-110	148	1	6c	6c	PROPN
hjic-110	148	2	was	be	AUX
hjic-110	148	3	a	a	DET
hjic-110	148	4	simple	simple	ADJ
hjic-110	148	5	summation	summation	NOUN
hjic-110	148	6	of	of	ADP
hjic-110	148	7	those	those	PRON
hjic-110	148	8	of	of	ADP
hjic-110	148	9	pure	pure	ADJ
hjic-110	148	10	compounds	compound	NOUN
hjic-110	148	11	.	.	PUNCT
hjic-110	149	1	in	in	ADP
hjic-110	149	2	contrast	contrast	NOUN
hjic-110	149	3	,	,	PUNCT
hjic-110	149	4	ftir	ftir	PROPN
hjic-110	149	5	spectra	spectra	PROPN
hjic-110	149	6	of	of	ADP
hjic-110	149	7	oxeglitazar	oxeglitazar	PROPN
hjic-110	149	8	/	/	SYM
hjic-110	149	9	pvp	pvp	PROPN
hjic-110	149	10	k17	k17	PROPN
hjic-110	149	11	coprecipitate	coprecipitate	PROPN
hjic-110	149	12	and	and	CCONJ
hjic-110	149	13	coevaporate	coevaporate	VERB
hjic-110	149	14	display	display	VERB
hjic-110	149	15	different	different	ADJ
hjic-110	149	16	absorption	absorption	NOUN
hjic-110	149	17	bands	band	NOUN
hjic-110	149	18	in	in	ADP
hjic-110	149	19	the	the	DET
hjic-110	149	20	carbonyl	carbonyl	NOUN
hjic-110	149	21	region	region	NOUN
hjic-110	149	22	(	(	PUNCT
hjic-110	149	23	fig	fig	NOUN
hjic-110	149	24	.	.	PUNCT
hjic-110	150	1	6d	6d	NUM
hjic-110	150	2	-	-	PUNCT
hjic-110	150	3	e	e	NOUN
hjic-110	150	4	)	)	PUNCT
hjic-110	150	5	.	.	PUNCT
hjic-110	151	1	a	a	DET
hjic-110	151	2	new	new	ADJ
hjic-110	151	3	band	band	NOUN
hjic-110	151	4	seems	seem	VERB
hjic-110	151	5	to	to	PART
hjic-110	151	6	appear	appear	VERB
hjic-110	151	7	at	at	ADP
hjic-110	151	8	about	about	ADV
hjic-110	151	9	1650	1650	NUM
hjic-110	151	10	cm-1	cm-1	NOUN
hjic-110	151	11	beneath	beneath	ADP
hjic-110	151	12	the	the	DET
hjic-110	151	13	superposed	superpose	VERB
hjic-110	151	14	νc	νc	NOUN
hjic-110	151	15	=	=	NOUN
hjic-110	151	16	o	o	NOUN
hjic-110	151	17	bands	band	NOUN
hjic-110	151	18	which	which	PRON
hjic-110	151	19	can	can	AUX
hjic-110	151	20	be	be	AUX
hjic-110	151	21	attributed	attribute	VERB
hjic-110	151	22	to	to	ADP
hjic-110	151	23	the	the	DET
hjic-110	151	24	carbonyl	carbonyl	NOUN
hjic-110	151	25	group	group	NOUN
hjic-110	151	26	of	of	ADP
hjic-110	151	27	pvp	pvp	PROPN
hjic-110	151	28	k17	k17	PROPN
hjic-110	151	29	engaged	engage	VERB
hjic-110	151	30	in	in	ADP
hjic-110	151	31	intermolecular	intermolecular	ADJ
hjic-110	151	32	hydrogen	hydrogen	NOUN
hjic-110	151	33	bonds	bond	NOUN
hjic-110	151	34	with	with	ADP
hjic-110	151	35	the	the	DET
hjic-110	151	36	carboxylic	carboxylic	ADJ
hjic-110	151	37	oh	oh	INTJ
hjic-110	151	38	of	of	ADP
hjic-110	151	39	oxeglitazar	oxeglitazar	NOUN
hjic-110	151	40	.	.	PUNCT
hjic-110	152	1	ftir	ftir	PROPN
hjic-110	152	2	spectra	spectra	PROPN
hjic-110	152	3	of	of	ADP
hjic-110	152	4	oxeglitazar	oxeglitazar	PROPN
hjic-110	152	5	/	/	SYM
hjic-110	152	6	poloxamer	poloxamer	NOUN
hjic-110	152	7	407	407	NUM
hjic-110	152	8	solid	solid	ADJ
hjic-110	152	9	dispersions	dispersion	NOUN
hjic-110	152	10	are	be	AUX
hjic-110	152	11	shown	show	VERB
hjic-110	152	12	in	in	ADP
hjic-110	152	13	fig	fig	NOUN
hjic-110	152	14	.	.	PUNCT
hjic-110	153	1	7	7	X
hjic-110	153	2	.	.	X
hjic-110	153	3	the	the	DET
hjic-110	153	4	position	position	NOUN
hjic-110	153	5	and	and	CCONJ
hjic-110	153	6	intensity	intensity	NOUN
hjic-110	153	7	of	of	ADP
hjic-110	153	8	the	the	DET
hjic-110	153	9	corresponding	correspond	VERB
hjic-110	153	10	bands	band	NOUN
hjic-110	153	11	were	be	AUX
hjic-110	153	12	similar	similar	ADJ
hjic-110	153	13	in	in	ADP
hjic-110	153	14	the	the	DET
hjic-110	153	15	spectra	spectra	NOUN
hjic-110	153	16	of	of	ADP
hjic-110	153	17	physical	physical	ADJ
hjic-110	153	18	mixture	mixture	NOUN
hjic-110	153	19	,	,	PUNCT
hjic-110	153	20	coprecipitate	coprecipitate	NOUN
hjic-110	153	21	and	and	CCONJ
hjic-110	153	22	coevaporate	coevaporate	VERB
hjic-110	153	23	,	,	PUNCT
hjic-110	153	24	suggesting	suggest	VERB
hjic-110	153	25	that	that	SCONJ
hjic-110	153	26	poloxamer	poloxamer	PROPN
hjic-110	153	27	407	407	NUM
hjic-110	153	28	did	do	AUX
hjic-110	153	29	not	not	PART
hjic-110	153	30	form	form	VERB
hjic-110	153	31	any	any	DET
hjic-110	153	32	hydrogen	hydrogen	NOUN
hjic-110	153	33	bonding	bonding	NOUN
hjic-110	153	34	with	with	ADP
hjic-110	153	35	oxeglitazar	oxeglitazar	NOUN
hjic-110	153	36	.	.	PUNCT
hjic-110	154	1	fig	fig	NOUN
hjic-110	154	2	.	.	PUNCT
hjic-110	155	1	6	6	NUM
hjic-110	155	2	.	.	X
hjic-110	155	3	ftir	ftir	PROPN
hjic-110	155	4	spectra	spectra	PROPN
hjic-110	155	5	of	of	ADP
hjic-110	155	6	solid	solid	ADJ
hjic-110	155	7	dispersions	dispersion	NOUN
hjic-110	155	8	of	of	ADP
hjic-110	155	9	oxeglitazar	oxeglitazar	NOUN
hjic-110	155	10	and	and	CCONJ
hjic-110	155	11	pvp	pvp	PROPN
hjic-110	155	12	k17	k17	PROPN
hjic-110	155	13	:	:	PUNCT
hjic-110	155	14	(	(	PUNCT
hjic-110	155	15	a	a	X
hjic-110	155	16	)	)	PUNCT
hjic-110	155	17	raw	raw	ADJ
hjic-110	155	18	drug	drug	NOUN
hjic-110	155	19	,	,	PUNCT
hjic-110	155	20	(	(	PUNCT
hjic-110	155	21	b	b	X
hjic-110	155	22	)	)	PUNCT
hjic-110	155	23	pvp	pvp	PROPN
hjic-110	155	24	k17	k17	PROPN
hjic-110	155	25	,	,	PUNCT
hjic-110	155	26	(	(	PUNCT
hjic-110	155	27	c	c	X
hjic-110	155	28	)	)	PUNCT
hjic-110	155	29	physical	physical	ADJ
hjic-110	155	30	mixture	mixture	NOUN
hjic-110	155	31	,	,	PUNCT
hjic-110	155	32	(	(	PUNCT
hjic-110	155	33	d	d	X
hjic-110	155	34	)	)	PUNCT
hjic-110	155	35	sas	sas	VERB
hjic-110	155	36	oxeglitazar	oxeglitazar	PROPN
hjic-110	155	37	/	/	SYM
hjic-110	155	38	pvp	pvp	PROPN
hjic-110	155	39	k17	k17	PROPN
hjic-110	155	40	,	,	PUNCT
hjic-110	155	41	(	(	PUNCT
hjic-110	155	42	e	e	NOUN
hjic-110	155	43	)	)	PUNCT
hjic-110	155	44	coe	coe	PROPN
hjic-110	155	45	oxeglitazar	oxeglitazar	PROPN
hjic-110	155	46	/	/	SYM
hjic-110	155	47	pvp	pvp	PROPN
hjic-110	155	48	k17	k17	PROPN
hjic-110	155	49	.	.	PROPN
hjic-110	155	50	46	46	NUM
hjic-110	155	51	fig	fig	NOUN
hjic-110	155	52	.	.	PUNCT
hjic-110	156	1	7	7	X
hjic-110	156	2	.	.	X
hjic-110	156	3	ftir	ftir	PROPN
hjic-110	156	4	spectra	spectra	PROPN
hjic-110	156	5	of	of	ADP
hjic-110	156	6	solid	solid	ADJ
hjic-110	156	7	dispersions	dispersion	NOUN
hjic-110	156	8	of	of	ADP
hjic-110	156	9	oxeglitazar	oxeglitazar	NOUN
hjic-110	156	10	and	and	CCONJ
hjic-110	156	11	poloxamer	poloxamer	NOUN
hjic-110	156	12	407	407	NUM
hjic-110	156	13	:	:	PUNCT
hjic-110	156	14	raw	raw	ADJ
hjic-110	156	15	drug	drug	NOUN
hjic-110	156	16	(	(	PUNCT
hjic-110	156	17	a	a	X
hjic-110	156	18	)	)	PUNCT
hjic-110	156	19	,	,	PUNCT
hjic-110	156	20	poloxamer	poloxamer	NOUN
hjic-110	156	21	407	407	NUM
hjic-110	156	22	(	(	PUNCT
hjic-110	156	23	b	b	NOUN
hjic-110	156	24	)	)	PUNCT
hjic-110	156	25	,	,	PUNCT
hjic-110	156	26	physical	physical	ADJ
hjic-110	156	27	mixture	mixture	NOUN
hjic-110	156	28	(	(	PUNCT
hjic-110	156	29	c	c	NOUN
hjic-110	156	30	)	)	PUNCT
hjic-110	156	31	,	,	PUNCT
hjic-110	156	32	sas	sa	VERB
hjic-110	156	33	oxeglitazar	oxeglitazar	PROPN
hjic-110	156	34	/	/	SYM
hjic-110	156	35	poloxamer	poloxamer	NOUN
hjic-110	156	36	407	407	NUM
hjic-110	156	37	(	(	PUNCT
hjic-110	156	38	d	d	NOUN
hjic-110	156	39	)	)	PUNCT
hjic-110	156	40	,	,	PUNCT
hjic-110	156	41	coe	coe	PROPN
hjic-110	156	42	oxeglitazar	oxeglitazar	PROPN
hjic-110	156	43	/	/	SYM
hjic-110	156	44	poloxamer	poloxamer	NOUN
hjic-110	156	45	407	407	NUM
hjic-110	156	46	(	(	PUNCT
hjic-110	156	47	e	e	NOUN
hjic-110	156	48	)	)	PUNCT
hjic-110	156	49	.	.	PUNCT
hjic-110	157	1	residual	residual	ADJ
hjic-110	157	2	solvent	solvent	NOUN
hjic-110	157	3	the	the	DET
hjic-110	157	4	residual	residual	ADJ
hjic-110	157	5	solvent	solvent	NOUN
hjic-110	157	6	content	content	NOUN
hjic-110	157	7	was	be	AUX
hjic-110	157	8	determined	determine	VERB
hjic-110	157	9	with	with	ADP
hjic-110	157	10	gc	gc	PROPN
hjic-110	157	11	analysis	analysis	NOUN
hjic-110	157	12	.	.	PUNCT
hjic-110	158	1	dcm	dcm	PROPN
hjic-110	158	2	is	be	AUX
hjic-110	158	3	a	a	DET
hjic-110	158	4	class	class	NOUN
hjic-110	158	5	2	2	NUM
hjic-110	158	6	solvent	solvent	NOUN
hjic-110	158	7	with	with	ADP
hjic-110	158	8	a	a	DET
hjic-110	158	9	permitted	permit	VERB
hjic-110	158	10	daily	daily	ADJ
hjic-110	158	11	exposure	exposure	NOUN
hjic-110	158	12	(	(	PUNCT
hjic-110	158	13	pde	pde	NOUN
hjic-110	158	14	)	)	PUNCT
hjic-110	158	15	of	of	ADP
hjic-110	158	16	6	6	NUM
hjic-110	158	17	mg	mg	NOUN
hjic-110	158	18	[	[	X
hjic-110	158	19	43	43	NUM
hjic-110	158	20	]	]	PUNCT
hjic-110	158	21	.	.	PUNCT
hjic-110	159	1	two	two	NUM
hjic-110	159	2	options	option	NOUN
hjic-110	159	3	are	be	AUX
hjic-110	159	4	available	available	ADJ
hjic-110	159	5	when	when	SCONJ
hjic-110	159	6	setting	set	VERB
hjic-110	159	7	limits	limit	NOUN
hjic-110	159	8	of	of	ADP
hjic-110	159	9	class	class	NOUN
hjic-110	159	10	2	2	NUM
hjic-110	159	11	solvents	solvent	NOUN
hjic-110	159	12	:	:	PUNCT
hjic-110	159	13	option	option	NOUN
hjic-110	159	14	1	1	NUM
hjic-110	159	15	may	may	AUX
hjic-110	159	16	be	be	AUX
hjic-110	159	17	applied	apply	VERB
hjic-110	159	18	if	if	SCONJ
hjic-110	159	19	the	the	DET
hjic-110	159	20	daily	daily	ADJ
hjic-110	159	21	dose	dose	NOUN
hjic-110	159	22	is	be	AUX
hjic-110	159	23	not	not	PART
hjic-110	159	24	known	know	VERB
hjic-110	159	25	or	or	CCONJ
hjic-110	159	26	fixed	fix	VERB
hjic-110	159	27	.	.	PUNCT
hjic-110	160	1	this	this	DET
hjic-110	160	2	option	option	NOUN
hjic-110	160	3	assumes	assume	VERB
hjic-110	160	4	a	a	DET
hjic-110	160	5	high	high	ADJ
hjic-110	160	6	dose	dose	NOUN
hjic-110	160	7	(	(	PUNCT
hjic-110	160	8	10	10	NUM
hjic-110	160	9	g	g	NOUN
hjic-110	160	10	/	/	SYM
hjic-110	160	11	day	day	NOUN
hjic-110	160	12	)	)	PUNCT
hjic-110	160	13	that	that	PRON
hjic-110	160	14	is	be	AUX
hjic-110	160	15	rarely	rarely	ADV
hjic-110	160	16	exceeded	exceed	VERB
hjic-110	160	17	.	.	PUNCT
hjic-110	161	1	option	option	NOUN
hjic-110	161	2	2	2	NUM
hjic-110	161	3	takes	take	VERB
hjic-110	161	4	into	into	ADP
hjic-110	161	5	account	account	NOUN
hjic-110	161	6	the	the	DET
hjic-110	161	7	daily	daily	ADJ
hjic-110	161	8	dose	dose	NOUN
hjic-110	161	9	or	or	CCONJ
hjic-110	161	10	the	the	DET
hjic-110	161	11	maximum	maximum	ADJ
hjic-110	161	12	daily	daily	NOUN
hjic-110	161	13	dose	dose	NOUN
hjic-110	161	14	if	if	SCONJ
hjic-110	161	15	the	the	DET
hjic-110	161	16	drug	drug	NOUN
hjic-110	161	17	is	be	AUX
hjic-110	161	18	not	not	PART
hjic-110	161	19	regularly	regularly	ADV
hjic-110	161	20	administered	administer	VERB
hjic-110	161	21	.	.	PUNCT
hjic-110	162	1	assuming	assume	VERB
hjic-110	162	2	a	a	DET
hjic-110	162	3	maximum	maximum	ADJ
hjic-110	162	4	daily	daily	ADJ
hjic-110	162	5	dose	dose	NOUN
hjic-110	162	6	of	of	ADP
hjic-110	162	7	400	400	NUM
hjic-110	162	8	mg	mg	PROPN
hjic-110	162	9	,	,	PUNCT
hjic-110	162	10	recommended	recommend	VERB
hjic-110	162	11	limits	limit	NOUN
hjic-110	162	12	of	of	ADP
hjic-110	162	13	dcm	dcm	PROPN
hjic-110	162	14	under	under	ADP
hjic-110	162	15	option	option	NOUN
hjic-110	162	16	1	1	NUM
hjic-110	162	17	and	and	CCONJ
hjic-110	162	18	option	option	NOUN
hjic-110	162	19	2	2	NUM
hjic-110	162	20	are	be	AUX
hjic-110	162	21	600	600	NUM
hjic-110	162	22	and	and	CCONJ
hjic-110	162	23	7500	7500	NUM
hjic-110	162	24	ppm	ppm	NOUN
hjic-110	162	25	,	,	PUNCT
hjic-110	162	26	respectively	respectively	ADV
hjic-110	162	27	.	.	PUNCT
hjic-110	163	1	results	result	NOUN
hjic-110	163	2	of	of	ADP
hjic-110	163	3	gc	gc	PROPN
hjic-110	163	4	analysis	analysis	NOUN
hjic-110	163	5	are	be	AUX
hjic-110	163	6	shown	show	VERB
hjic-110	163	7	in	in	ADP
hjic-110	163	8	table	table	NOUN
hjic-110	163	9	1	1	NUM
hjic-110	163	10	.	.	PUNCT
hjic-110	164	1	all	all	DET
hjic-110	164	2	oxeglitazar	oxeglitazar	NOUN
hjic-110	164	3	/	/	SYM
hjic-110	164	4	poloxamer	poloxamer	NOUN
hjic-110	164	5	407	407	NUM
hjic-110	164	6	formulations	formulation	NOUN
hjic-110	164	7	met	meet	VERB
hjic-110	164	8	ich	ich	NOUN
hjic-110	164	9	requirements	requirement	NOUN
hjic-110	164	10	under	under	ADP
hjic-110	164	11	option	option	NOUN
hjic-110	164	12	2	2	NUM
hjic-110	164	13	.	.	PUNCT
hjic-110	164	14	residual	residual	ADJ
hjic-110	164	15	dcm	dcm	PROPN
hjic-110	164	16	content	content	NOUN
hjic-110	164	17	was	be	AUX
hjic-110	164	18	even	even	ADV
hjic-110	164	19	lower	low	ADJ
hjic-110	164	20	than	than	ADP
hjic-110	164	21	the	the	DET
hjic-110	164	22	stricter	strict	ADJ
hjic-110	164	23	option	option	NOUN
hjic-110	164	24	1	1	NUM
hjic-110	164	25	limit	limit	NOUN
hjic-110	164	26	after	after	ADP
hjic-110	164	27	vacuum	vacuum	NOUN
hjic-110	164	28	drying	dry	VERB
hjic-110	164	29	(	(	PUNCT
hjic-110	164	30	sas	sa	NOUN
hjic-110	164	31	-	-	PUNCT
hjic-110	164	32	vd	vd	NOUN
hjic-110	164	33	and	and	CCONJ
hjic-110	164	34	coe	coe	PROPN
hjic-110	164	35	-	-	PUNCT
hjic-110	164	36	vd	vd	NOUN
hjic-110	164	37	)	)	PUNCT
hjic-110	164	38	.	.	PUNCT
hjic-110	165	1	the	the	DET
hjic-110	165	2	oxeglitazar	oxeglitazar	NOUN
hjic-110	165	3	/	/	SYM
hjic-110	165	4	pvp	pvp	NOUN
hjic-110	165	5	formulations	formulation	NOUN
hjic-110	165	6	have	have	AUX
hjic-110	165	7	retained	retain	VERB
hjic-110	165	8	much	much	ADV
hjic-110	165	9	more	more	ADJ
hjic-110	165	10	solvent	solvent	ADJ
hjic-110	165	11	.	.	PUNCT
hjic-110	166	1	vacuum	vacuum	NOUN
hjic-110	166	2	dried	dry	VERB
hjic-110	166	3	coprecipitate	coprecipitate	NOUN
hjic-110	166	4	and	and	CCONJ
hjic-110	166	5	coevaporate	coevaporate	VERB
hjic-110	166	6	met	meet	VERB
hjic-110	166	7	option	option	NOUN
hjic-110	166	8	2	2	NUM
hjic-110	166	9	limit	limit	NOUN
hjic-110	166	10	but	but	CCONJ
hjic-110	166	11	exceeded	exceed	VERB
hjic-110	166	12	option	option	NOUN
hjic-110	166	13	1	1	NUM
hjic-110	166	14	limit	limit	NOUN
hjic-110	166	15	.	.	PUNCT
hjic-110	167	1	table	table	NOUN
hjic-110	167	2	1	1	NUM
hjic-110	167	3	residual	residual	ADJ
hjic-110	167	4	dcm	dcm	NOUN
hjic-110	167	5	content	content	NOUN
hjic-110	167	6	(	(	PUNCT
hjic-110	167	7	ppm	ppm	NOUN
hjic-110	167	8	)	)	PUNCT
hjic-110	167	9	.	.	PUNCT
hjic-110	168	1	method	method	PROPN
hjic-110	168	2	poloxamer	poloxamer	PROPN
hjic-110	168	3	407	407	NUM
hjic-110	168	4	pvp	pvp	PROPN
hjic-110	168	5	k17	k17	PROPN
hjic-110	168	6	sas	sas	PROPN
hjic-110	168	7	804	804	NUM
hjic-110	168	8	±	±	NUM
hjic-110	168	9	189	189	NUM
hjic-110	168	10	13500	13500	NUM
hjic-110	168	11	±	±	NUM
hjic-110	168	12	248	248	NUM
hjic-110	168	13	sas	sa	NOUN
hjic-110	168	14	-	-	PUNCT
hjic-110	168	15	vd	vd	NOUN
hjic-110	168	16	87	87	NUM
hjic-110	168	17	±	±	NUM
hjic-110	168	18	3	3	NUM
hjic-110	168	19	618	618	NUM
hjic-110	168	20	±	±	NUM
hjic-110	168	21	23	23	NUM
hjic-110	168	22	coe	coe	PROPN
hjic-110	168	23	1294	1294	NUM
hjic-110	168	24	±	±	NUM
hjic-110	168	25	97	97	NUM
hjic-110	168	26	18770	18770	NUM
hjic-110	168	27	±	±	NUM
hjic-110	168	28	817	817	NUM
hjic-110	168	29	coe	coe	PROPN
hjic-110	168	30	-	-	PUNCT
hjic-110	168	31	vd	vd	NOUN
hjic-110	168	32	111	111	NUM
hjic-110	168	33	±	±	NUM
hjic-110	168	34	4	4	NUM
hjic-110	168	35	668	668	NUM
hjic-110	168	36	±	±	NUM
hjic-110	168	37	29	29	NUM
hjic-110	168	38	drug	drug	NOUN
hjic-110	168	39	content	content	NOUN
hjic-110	168	40	drug	drug	NOUN
hjic-110	168	41	contents	content	NOUN
hjic-110	168	42	are	be	AUX
hjic-110	168	43	listed	list	VERB
hjic-110	168	44	in	in	ADP
hjic-110	168	45	table	table	NOUN
hjic-110	168	46	2	2	NUM
hjic-110	168	47	.	.	PUNCT
hjic-110	169	1	both	both	PRON
hjic-110	169	2	sas	sa	VERB
hjic-110	169	3	prepared	prepared	ADJ
hjic-110	169	4	powders	powder	NOUN
hjic-110	169	5	contained	contain	VERB
hjic-110	169	6	more	more	ADJ
hjic-110	169	7	oxeglitazar	oxeglitazar	NOUN
hjic-110	169	8	than	than	ADP
hjic-110	169	9	the	the	DET
hjic-110	169	10	nominal	nominal	ADJ
hjic-110	169	11	value	value	NOUN
hjic-110	169	12	(	(	PUNCT
hjic-110	169	13	50	50	NUM
hjic-110	169	14	wt	wt	NOUN
hjic-110	169	15	.	.	NOUN
hjic-110	169	16	%	%	NOUN
hjic-110	169	17	)	)	PUNCT
hjic-110	169	18	suggesting	suggest	VERB
hjic-110	169	19	that	that	SCONJ
hjic-110	169	20	the	the	DET
hjic-110	169	21	dcm	dcm	ADJ
hjic-110	169	22	-	-	PUNCT
hjic-110	169	23	co2	co2	NOUN
hjic-110	169	24	mixture	mixture	NOUN
hjic-110	169	25	dissolved	dissolve	VERB
hjic-110	169	26	and	and	CCONJ
hjic-110	169	27	washed	wash	VERB
hjic-110	169	28	out	out	ADP
hjic-110	169	29	more	more	ADV
hjic-110	169	30	excipient	excipient	ADJ
hjic-110	169	31	than	than	ADP
hjic-110	169	32	active	active	ADJ
hjic-110	169	33	substance	substance	NOUN
hjic-110	169	34	.	.	PUNCT
hjic-110	170	1	in	in	ADP
hjic-110	170	2	contrast	contrast	NOUN
hjic-110	170	3	,	,	PUNCT
hjic-110	170	4	drug	drug	NOUN
hjic-110	170	5	contents	content	NOUN
hjic-110	170	6	in	in	ADP
hjic-110	170	7	coevaporates	coevaporate	NOUN
hjic-110	170	8	were	be	AUX
hjic-110	170	9	marginally	marginally	ADV
hjic-110	170	10	below	below	ADP
hjic-110	170	11	the	the	DET
hjic-110	170	12	nominal	nominal	ADJ
hjic-110	170	13	value	value	NOUN
hjic-110	170	14	.	.	PUNCT
hjic-110	171	1	this	this	DET
hjic-110	171	2	deviation	deviation	NOUN
hjic-110	171	3	has	have	VERB
hjic-110	171	4	to	to	PART
hjic-110	171	5	be	be	AUX
hjic-110	171	6	taken	take	VERB
hjic-110	171	7	into	into	ADP
hjic-110	171	8	account	account	NOUN
hjic-110	171	9	in	in	ADP
hjic-110	171	10	the	the	DET
hjic-110	171	11	preparation	preparation	NOUN
hjic-110	171	12	of	of	ADP
hjic-110	171	13	solid	solid	ADJ
hjic-110	171	14	oral	oral	ADJ
hjic-110	171	15	dosage	dosage	NOUN
hjic-110	171	16	forms	form	NOUN
hjic-110	171	17	with	with	ADP
hjic-110	171	18	high	high	ADJ
hjic-110	171	19	content	content	NOUN
hjic-110	171	20	uniformity	uniformity	NOUN
hjic-110	171	21	.	.	PUNCT
hjic-110	172	1	table	table	NOUN
hjic-110	172	2	2	2	NUM
hjic-110	172	3	oxeglitazar	oxeglitazar	NOUN
hjic-110	172	4	content	content	NOUN
hjic-110	172	5	(	(	PUNCT
hjic-110	172	6	wt	wt	PROPN
hjic-110	172	7	.	.	NOUN
hjic-110	172	8	%	%	NOUN
hjic-110	172	9	)	)	PUNCT
hjic-110	172	10	.	.	PUNCT
hjic-110	173	1	method	method	PROPN
hjic-110	173	2	poloxamer	poloxamer	PROPN
hjic-110	173	3	407	407	NUM
hjic-110	173	4	pvp	pvp	PROPN
hjic-110	173	5	k17	k17	PROPN
hjic-110	173	6	sas	sas	PROPN
hjic-110	173	7	53.5	53.5	NUM
hjic-110	173	8	±	±	NUM
hjic-110	173	9	0.4	0.4	NUM
hjic-110	173	10	57.9	57.9	NUM
hjic-110	173	11	±	±	NUM
hjic-110	173	12	0.3	0.3	NUM
hjic-110	173	13	coe	coe	PROPN
hjic-110	173	14	47.0	47.0	NUM
hjic-110	173	15	±	±	NUM
hjic-110	173	16	0.9	0.9	NUM
hjic-110	173	17	47.8	47.8	NUM
hjic-110	173	18	±	±	NUM
hjic-110	173	19	0.7	0.7	NUM
hjic-110	173	20	solubility	solubility	NOUN
hjic-110	173	21	studies	study	NOUN
hjic-110	173	22	oxeglitazar	oxeglitazar	VERB
hjic-110	173	23	solubility	solubility	NOUN
hjic-110	173	24	as	as	ADP
hjic-110	173	25	a	a	DET
hjic-110	173	26	function	function	NOUN
hjic-110	173	27	of	of	ADP
hjic-110	173	28	excipient	excipient	ADJ
hjic-110	173	29	concentration	concentration	NOUN
hjic-110	173	30	is	be	AUX
hjic-110	173	31	shown	show	VERB
hjic-110	173	32	in	in	ADP
hjic-110	173	33	fig	fig	NOUN
hjic-110	173	34	.	.	PUNCT
hjic-110	174	1	8	8	X
hjic-110	174	2	.	.	X
hjic-110	174	3	solubility	solubility	NOUN
hjic-110	174	4	was	be	AUX
hjic-110	174	5	measured	measure	VERB
hjic-110	174	6	in	in	ADP
hjic-110	174	7	ph	ph	ADJ
hjic-110	174	8	7.4	7.4	NUM
hjic-110	174	9	phosphate	phosphate	NOUN
hjic-110	174	10	buffer	buffer	NOUN
hjic-110	174	11	medium	medium	NOUN
hjic-110	174	12	at	at	ADP
hjic-110	174	13	37	37	NUM
hjic-110	174	14	°	°	NOUN
hjic-110	174	15	c	c	NOUN
hjic-110	174	16	.	.	PUNCT
hjic-110	175	1	the	the	DET
hjic-110	175	2	increase	increase	NOUN
hjic-110	175	3	in	in	ADP
hjic-110	175	4	solubility	solubility	NOUN
hjic-110	175	5	was	be	AUX
hjic-110	175	6	linear	linear	ADJ
hjic-110	175	7	with	with	ADP
hjic-110	175	8	respect	respect	NOUN
hjic-110	175	9	to	to	ADP
hjic-110	175	10	the	the	DET
hjic-110	175	11	weight	weight	NOUN
hjic-110	175	12	fraction	fraction	NOUN
hjic-110	175	13	of	of	ADP
hjic-110	175	14	both	both	DET
hjic-110	175	15	polymers	polymer	NOUN
hjic-110	175	16	but	but	CCONJ
hjic-110	175	17	the	the	DET
hjic-110	175	18	curve	curve	NOUN
hjic-110	175	19	of	of	ADP
hjic-110	175	20	poloxamer	poloxamer	PROPN
hjic-110	175	21	407	407	NUM
hjic-110	175	22	was	be	AUX
hjic-110	175	23	much	much	ADV
hjic-110	175	24	more	more	ADV
hjic-110	175	25	steeper	steep	ADJ
hjic-110	175	26	.	.	PUNCT
hjic-110	176	1	the	the	DET
hjic-110	176	2	increase	increase	NOUN
hjic-110	176	3	in	in	ADP
hjic-110	176	4	oxeglitazar	oxeglitazar	NOUN
hjic-110	176	5	solubility	solubility	NOUN
hjic-110	176	6	was	be	AUX
hjic-110	176	7	8.7and	8.7and	NUM
hjic-110	176	8	3.9	3.9	NUM
hjic-110	176	9	-	-	NOUN
hjic-110	176	10	fold	fold	ADJ
hjic-110	176	11	in	in	ADP
hjic-110	176	12	dissolution	dissolution	ADJ
hjic-110	176	13	media	medium	NOUN
hjic-110	176	14	with	with	ADP
hjic-110	176	15	10	10	NUM
hjic-110	176	16	%	%	NOUN
hjic-110	176	17	w	w	NOUN
hjic-110	176	18	/	/	SYM
hjic-110	176	19	v	v	NOUN
hjic-110	176	20	poloxamer	poloxamer	NOUN
hjic-110	176	21	407	407	NUM
hjic-110	176	22	and	and	CCONJ
hjic-110	176	23	pvp	pvp	PROPN
hjic-110	176	24	k17	k17	PROPN
hjic-110	176	25	,	,	PUNCT
hjic-110	176	26	respectively	respectively	ADV
hjic-110	176	27	.	.	PUNCT
hjic-110	177	1	thus	thus	ADV
hjic-110	177	2	,	,	PUNCT
hjic-110	177	3	poloxamer	poloxamer	PROPN
hjic-110	177	4	407	407	NUM
hjic-110	177	5	solubilized	solubilize	VERB
hjic-110	177	6	more	more	ADJ
hjic-110	177	7	than	than	ADP
hjic-110	177	8	twice	twice	ADV
hjic-110	177	9	as	as	ADV
hjic-110	177	10	much	much	ADJ
hjic-110	177	11	drug	drug	NOUN
hjic-110	177	12	as	as	ADP
hjic-110	177	13	pvp	pvp	PROPN
hjic-110	177	14	k17	k17	PROPN
hjic-110	177	15	.	.	PUNCT
hjic-110	177	16	fig	fig	PROPN
hjic-110	177	17	.	.	PUNCT
hjic-110	178	1	8	8	NUM
hjic-110	178	2	.	.	NOUN
hjic-110	178	3	phase	phase	NOUN
hjic-110	178	4	solubility	solubility	NOUN
hjic-110	178	5	diagram	diagram	NOUN
hjic-110	178	6	of	of	ADP
hjic-110	178	7	oxeglitazar	oxeglitazar	NOUN
hjic-110	178	8	in	in	ADP
hjic-110	178	9	ph	ph	ADJ
hjic-110	178	10	7.4	7.4	NUM
hjic-110	178	11	phosphate	phosphate	NOUN
hjic-110	178	12	buffer	buffer	NOUN
hjic-110	178	13	media	medium	NOUN
hjic-110	178	14	with	with	ADP
hjic-110	178	15	various	various	ADJ
hjic-110	178	16	poloxamer	poloxamer	NOUN
hjic-110	178	17	407	407	NUM
hjic-110	178	18	and	and	CCONJ
hjic-110	178	19	pvp	pvp	PROPN
hjic-110	178	20	k17	k17	PROPN
hjic-110	178	21	concentrations	concentration	NOUN
hjic-110	178	22	.	.	PUNCT
hjic-110	179	1	dissolution	dissolution	PROPN
hjic-110	179	2	studies	study	NOUN
hjic-110	179	3	dissolution	dissolution	ADJ
hjic-110	179	4	profiles	profile	NOUN
hjic-110	179	5	in	in	ADP
hjic-110	179	6	fig	fig	NOUN
hjic-110	179	7	.	.	PUNCT
hjic-110	180	1	9	9	NUM
hjic-110	180	2	and	and	CCONJ
hjic-110	180	3	fig	fig	NOUN
hjic-110	180	4	.	.	PUNCT
hjic-110	181	1	10	10	NUM
hjic-110	181	2	illustrate	illustrate	VERB
hjic-110	181	3	the	the	DET
hjic-110	181	4	dissolution	dissolution	NOUN
hjic-110	181	5	kinetics	kinetic	NOUN
hjic-110	181	6	of	of	ADP
hjic-110	181	7	drug	drug	NOUN
hjic-110	181	8	-	-	PUNCT
hjic-110	181	9	carrier	carrier	NOUN
hjic-110	181	10	solid	solid	ADJ
hjic-110	181	11	dispersions	dispersion	NOUN
hjic-110	181	12	,	,	PUNCT
hjic-110	181	13	physical	physical	ADJ
hjic-110	181	14	mixtures	mixture	NOUN
hjic-110	181	15	and	and	CCONJ
hjic-110	181	16	raw	raw	ADJ
hjic-110	181	17	drug	drug	NOUN
hjic-110	181	18	in	in	ADP
hjic-110	181	19	ph	ph	ADJ
hjic-110	181	20	7.4	7.4	NUM
hjic-110	181	21	phosphate	phosphate	NOUN
hjic-110	181	22	buffer	buffer	NOUN
hjic-110	181	23	medium	medium	NOUN
hjic-110	181	24	.	.	PUNCT
hjic-110	182	1	coprecipitates	coprecipitate	NOUN
hjic-110	182	2	and	and	CCONJ
hjic-110	182	3	coevaporates	coevaporate	NOUN
hjic-110	182	4	exhibited	exhibit	VERB
hjic-110	182	5	significantly	significantly	ADV
hjic-110	182	6	higher	high	ADJ
hjic-110	182	7	dissolution	dissolution	NOUN
hjic-110	182	8	rates	rate	NOUN
hjic-110	182	9	compared	compare	VERB
hjic-110	182	10	to	to	ADP
hjic-110	182	11	conventionally	conventionally	ADV
hjic-110	182	12	crystallized	crystallize	VERB
hjic-110	182	13	oxeglitazar	oxeglitazar	NOUN
hjic-110	182	14	and	and	CCONJ
hjic-110	182	15	physical	physical	ADJ
hjic-110	182	16	mixtures	mixture	NOUN
hjic-110	182	17	.	.	PUNCT
hjic-110	183	1	at	at	ADP
hjic-110	183	2	5	5	NUM
hjic-110	183	3	min	min	NOUN
hjic-110	183	4	,	,	PUNCT
hjic-110	183	5	dissolved	dissolve	VERB
hjic-110	183	6	oxeglitazar	oxeglitazar	NOUN
hjic-110	183	7	from	from	ADP
hjic-110	183	8	pvp	pvp	PROPN
hjic-110	183	9	k17	k17	PROPN
hjic-110	183	10	coevaporate	coevaporate	NOUN
hjic-110	183	11	and	and	CCONJ
hjic-110	183	12	coprecipitate	coprecipitate	NOUN
hjic-110	183	13	attained	attain	VERB
hjic-110	183	14	85.6	85.6	NUM
hjic-110	183	15	and	and	CCONJ
hjic-110	183	16	64.3	64.3	NUM
hjic-110	183	17	%	%	NOUN
hjic-110	183	18	,	,	PUNCT
hjic-110	183	19	while	while	SCONJ
hjic-110	183	20	only	only	ADV
hjic-110	183	21	30.5	30.5	NUM
hjic-110	183	22	%	%	NOUN
hjic-110	183	23	of	of	ADP
hjic-110	183	24	the	the	DET
hjic-110	183	25	raw	raw	ADJ
hjic-110	183	26	drug	drug	NOUN
hjic-110	183	27	were	be	AUX
hjic-110	183	28	dissolved	dissolve	VERB
hjic-110	183	29	.	.	PUNCT
hjic-110	184	1	remarkable	remarkable	ADJ
hjic-110	184	2	improvements	improvement	NOUN
hjic-110	184	3	were	be	AUX
hjic-110	184	4	achieved	achieve	VERB
hjic-110	184	5	with	with	ADP
hjic-110	184	6	poloxamer	poloxamer	PROPN
hjic-110	184	7	407	407	NUM
hjic-110	184	8	as	as	ADV
hjic-110	184	9	well	well	ADV
hjic-110	184	10	.	.	PUNCT
hjic-110	185	1	61.9	61.9	NUM
hjic-110	185	2	and	and	CCONJ
hjic-110	185	3	57.9	57.9	NUM
hjic-110	185	4	%	%	NOUN
hjic-110	185	5	of	of	ADP
hjic-110	185	6	the	the	DET
hjic-110	185	7	incorporated	incorporated	ADJ
hjic-110	185	8	oxeglitazar	oxeglitazar	NOUN
hjic-110	185	9	were	be	AUX
hjic-110	185	10	dissolved	dissolve	VERB
hjic-110	185	11	from	from	ADP
hjic-110	185	12	the	the	DET
hjic-110	185	13	sas	sas	PROPN
hjic-110	185	14	prepared	prepare	VERB
hjic-110	185	15	solid	solid	ADJ
hjic-110	185	16	dispersion	dispersion	NOUN
hjic-110	185	17	and	and	CCONJ
hjic-110	185	18	the	the	DET
hjic-110	185	19	coevaporate	coevaporate	NOUN
hjic-110	185	20	,	,	PUNCT
hjic-110	185	21	respectively	respectively	ADV
hjic-110	185	22	.	.	PUNCT
hjic-110	186	1	47	47	NUM
hjic-110	186	2	fig	fig	NOUN
hjic-110	186	3	.	.	PUNCT
hjic-110	187	1	9	9	X
hjic-110	187	2	.	.	X
hjic-110	187	3	dissolution	dissolution	ADJ
hjic-110	187	4	profiles	profile	NOUN
hjic-110	187	5	of	of	ADP
hjic-110	187	6	oxeglitazar	oxeglitazar	NOUN
hjic-110	187	7	/	/	SYM
hjic-110	187	8	poloxamer	poloxamer	NOUN
hjic-110	187	9	407	407	NUM
hjic-110	187	10	solid	solid	ADJ
hjic-110	187	11	dispersions	dispersion	NOUN
hjic-110	187	12	,	,	PUNCT
hjic-110	187	13	physical	physical	ADJ
hjic-110	187	14	mixture	mixture	NOUN
hjic-110	187	15	and	and	CCONJ
hjic-110	187	16	raw	raw	ADJ
hjic-110	187	17	drug	drug	NOUN
hjic-110	187	18	.	.	PUNCT
hjic-110	188	1	fig	fig	NOUN
hjic-110	188	2	.	.	PUNCT
hjic-110	189	1	10	10	NUM
hjic-110	189	2	.	.	PUNCT
hjic-110	190	1	dissolution	dissolution	ADJ
hjic-110	190	2	profiles	profile	NOUN
hjic-110	190	3	of	of	ADP
hjic-110	190	4	oxeglitazar	oxeglitazar	NOUN
hjic-110	190	5	/	/	SYM
hjic-110	190	6	pvp	pvp	PROPN
hjic-110	190	7	k17	k17	PROPN
hjic-110	190	8	solid	solid	ADJ
hjic-110	190	9	dispersions	dispersion	NOUN
hjic-110	190	10	,	,	PUNCT
hjic-110	190	11	physical	physical	ADJ
hjic-110	190	12	mixture	mixture	NOUN
hjic-110	190	13	and	and	CCONJ
hjic-110	190	14	raw	raw	ADJ
hjic-110	190	15	drug	drug	NOUN
hjic-110	190	16	.	.	PUNCT
hjic-110	191	1	discussion	discussion	NOUN
hjic-110	191	2	formulations	formulation	NOUN
hjic-110	191	3	were	be	AUX
hjic-110	191	4	shown	show	VERB
hjic-110	191	5	to	to	PART
hjic-110	191	6	have	have	VERB
hjic-110	191	7	very	very	ADV
hjic-110	191	8	different	different	ADJ
hjic-110	191	9	morphology	morphology	NOUN
hjic-110	191	10	depending	depend	VERB
hjic-110	191	11	on	on	ADP
hjic-110	191	12	the	the	DET
hjic-110	191	13	method	method	NOUN
hjic-110	191	14	of	of	ADP
hjic-110	191	15	preparation	preparation	NOUN
hjic-110	191	16	and	and	CCONJ
hjic-110	191	17	the	the	DET
hjic-110	191	18	excipient	excipient	NOUN
hjic-110	191	19	involved	involve	VERB
hjic-110	191	20	.	.	PUNCT
hjic-110	192	1	oxeglitazar	oxeglitazar	NOUN
hjic-110	192	2	/	/	SYM
hjic-110	192	3	poloxamer	poloxamer	NOUN
hjic-110	192	4	407	407	NUM
hjic-110	192	5	coprecipitate	coprecipitate	NOUN
hjic-110	192	6	consisted	consist	VERB
hjic-110	192	7	of	of	ADP
hjic-110	192	8	aggregated	aggregate	VERB
hjic-110	192	9	acicular	acicular	ADJ
hjic-110	192	10	particles	particle	NOUN
hjic-110	192	11	similar	similar	ADJ
hjic-110	192	12	to	to	ADP
hjic-110	192	13	those	those	PRON
hjic-110	192	14	observed	observe	VERB
hjic-110	192	15	for	for	ADP
hjic-110	192	16	the	the	DET
hjic-110	192	17	raw	raw	ADJ
hjic-110	192	18	drug	drug	NOUN
hjic-110	192	19	.	.	PUNCT
hjic-110	193	1	unusually	unusually	ADV
hjic-110	193	2	large	large	ADJ
hjic-110	193	3	particle	particle	NOUN
hjic-110	193	4	size	size	NOUN
hjic-110	193	5	was	be	AUX
hjic-110	193	6	observed	observe	VERB
hjic-110	193	7	in	in	ADP
hjic-110	193	8	comparison	comparison	NOUN
hjic-110	193	9	with	with	ADP
hjic-110	193	10	other	other	ADJ
hjic-110	193	11	scf	scf	PROPN
hjic-110	193	12	processed	process	VERB
hjic-110	193	13	products	product	NOUN
hjic-110	193	14	[	[	X
hjic-110	193	15	13,33,34	13,33,34	NUM
hjic-110	193	16	]	]	PUNCT
hjic-110	193	17	.	.	PUNCT
hjic-110	194	1	one	one	NUM
hjic-110	194	2	possible	possible	ADJ
hjic-110	194	3	explanation	explanation	NOUN
hjic-110	194	4	is	be	AUX
hjic-110	194	5	that	that	SCONJ
hjic-110	194	6	poloxamer	poloxamer	PROPN
hjic-110	194	7	407	407	NUM
hjic-110	194	8	could	could	AUX
hjic-110	194	9	not	not	PART
hjic-110	194	10	inhibit	inhibit	VERB
hjic-110	194	11	the	the	DET
hjic-110	194	12	growth	growth	NOUN
hjic-110	194	13	of	of	ADP
hjic-110	194	14	oxeglitazar	oxeglitazar	NOUN
hjic-110	194	15	crystals	crystal	NOUN
hjic-110	194	16	which	which	PRON
hjic-110	194	17	in	in	ADP
hjic-110	194	18	turn	turn	NOUN
hjic-110	194	19	have	have	AUX
hjic-110	194	20	kept	keep	VERB
hjic-110	194	21	on	on	ADP
hjic-110	194	22	growing	grow	VERB
hjic-110	194	23	throughout	throughout	ADP
hjic-110	194	24	the	the	DET
hjic-110	194	25	whole	whole	ADJ
hjic-110	194	26	precipitation	precipitation	NOUN
hjic-110	194	27	process	process	NOUN
hjic-110	194	28	.	.	PUNCT
hjic-110	195	1	this	this	DET
hjic-110	195	2	theory	theory	NOUN
hjic-110	195	3	seems	seem	VERB
hjic-110	195	4	to	to	PART
hjic-110	195	5	be	be	AUX
hjic-110	195	6	consistent	consistent	ADJ
hjic-110	195	7	with	with	ADP
hjic-110	195	8	the	the	DET
hjic-110	195	9	observations	observation	NOUN
hjic-110	195	10	of	of	ADP
hjic-110	195	11	bristow	bristow	PROPN
hjic-110	195	12	et	et	PROPN
hjic-110	195	13	al	al	PROPN
hjic-110	195	14	.	.	PROPN
hjic-110	195	15	who	who	PRON
hjic-110	195	16	found	find	VERB
hjic-110	195	17	that	that	PRON
hjic-110	195	18	mean	mean	VERB
hjic-110	195	19	particle	particle	NOUN
hjic-110	195	20	size	size	NOUN
hjic-110	195	21	of	of	ADP
hjic-110	195	22	seds	sed	NOUN
hjic-110	195	23	prepared	prepare	VERB
hjic-110	195	24	paracetamol	paracetamol	NOUN
hjic-110	195	25	increased	increase	VERB
hjic-110	195	26	linearly	linearly	ADV
hjic-110	195	27	with	with	ADP
hjic-110	195	28	the	the	DET
hjic-110	195	29	time	time	NOUN
hjic-110	195	30	of	of	ADP
hjic-110	195	31	precipitation	precipitation	NOUN
hjic-110	195	32	process	process	NOUN
hjic-110	195	33	[	[	X
hjic-110	195	34	44	44	NUM
hjic-110	195	35	]	]	PUNCT
hjic-110	195	36	.	.	PUNCT
hjic-110	196	1	large	large	ADJ
hjic-110	196	2	particle	particle	NOUN
hjic-110	196	3	size	size	NOUN
hjic-110	196	4	implies	imply	VERB
hjic-110	196	5	low	low	ADJ
hjic-110	196	6	saturation	saturation	NOUN
hjic-110	196	7	ratio	ratio	NOUN
hjic-110	196	8	but	but	CCONJ
hjic-110	196	9	this	this	DET
hjic-110	196	10	theory	theory	NOUN
hjic-110	196	11	can	can	AUX
hjic-110	196	12	not	not	PART
hjic-110	196	13	be	be	AUX
hjic-110	196	14	verified	verify	VERB
hjic-110	196	15	in	in	ADP
hjic-110	196	16	the	the	DET
hjic-110	196	17	lack	lack	NOUN
hjic-110	196	18	of	of	ADP
hjic-110	196	19	data	datum	NOUN
hjic-110	196	20	on	on	ADP
hjic-110	196	21	equilibrium	equilibrium	NOUN
hjic-110	196	22	solubility	solubility	NOUN
hjic-110	196	23	.	.	PUNCT
hjic-110	197	1	acicular	acicular	ADJ
hjic-110	197	2	particles	particle	NOUN
hjic-110	197	3	were	be	AUX
hjic-110	197	4	seen	see	VERB
hjic-110	197	5	in	in	ADP
hjic-110	197	6	oxeglitazar	oxeglitazar	NOUN
hjic-110	197	7	/	/	SYM
hjic-110	197	8	poloxamer	poloxamer	NOUN
hjic-110	197	9	407	407	NUM
hjic-110	197	10	coevaporate	coevaporate	VERB
hjic-110	197	11	as	as	ADV
hjic-110	197	12	well	well	ADV
hjic-110	197	13	suggesting	suggest	VERB
hjic-110	197	14	that	that	SCONJ
hjic-110	197	15	poloxamer	poloxamer	PROPN
hjic-110	197	16	407	407	NUM
hjic-110	197	17	did	do	AUX
hjic-110	197	18	not	not	PART
hjic-110	197	19	form	form	VERB
hjic-110	197	20	a	a	DET
hjic-110	197	21	single	single	ADJ
hjic-110	197	22	phase	phase	NOUN
hjic-110	197	23	solid	solid	ADJ
hjic-110	197	24	solution	solution	NOUN
hjic-110	197	25	in	in	ADP
hjic-110	197	26	either	either	DET
hjic-110	197	27	process	process	NOUN
hjic-110	197	28	.	.	PUNCT
hjic-110	198	1	primary	primary	ADJ
hjic-110	198	2	particle	particle	NOUN
hjic-110	198	3	size	size	NOUN
hjic-110	198	4	of	of	ADP
hjic-110	198	5	sas	sas	PROPN
hjic-110	198	6	prepared	prepare	VERB
hjic-110	198	7	oxeglitazar	oxeglitazar	NOUN
hjic-110	198	8	/	/	SYM
hjic-110	198	9	pvp	pvp	PROPN
hjic-110	198	10	k17	k17	PROPN
hjic-110	198	11	was	be	AUX
hjic-110	198	12	still	still	ADV
hjic-110	198	13	very	very	ADV
hjic-110	198	14	large	large	ADJ
hjic-110	198	15	but	but	CCONJ
hjic-110	198	16	needle	needle	NOUN
hjic-110	198	17	-	-	PUNCT
hjic-110	198	18	like	like	ADJ
hjic-110	198	19	shape	shape	NOUN
hjic-110	198	20	was	be	AUX
hjic-110	198	21	successfully	successfully	ADV
hjic-110	198	22	changed	change	VERB
hjic-110	198	23	into	into	ADP
hjic-110	198	24	tabular	tabular	PROPN
hjic-110	198	25	one	one	NUM
hjic-110	198	26	.	.	PUNCT
hjic-110	199	1	sem	sem	NOUN
hjic-110	199	2	micrographs	micrograph	NOUN
hjic-110	199	3	showed	show	VERB
hjic-110	199	4	aggregated	aggregate	VERB
hjic-110	199	5	platelets	platelet	NOUN
hjic-110	199	6	with	with	ADP
hjic-110	199	7	a	a	DET
hjic-110	199	8	thickness	thickness	NOUN
hjic-110	199	9	of	of	ADP
hjic-110	199	10	a	a	DET
hjic-110	199	11	few	few	ADJ
hjic-110	199	12	micrometers	micrometer	NOUN
hjic-110	199	13	.	.	PUNCT
hjic-110	200	1	in	in	ADP
hjic-110	200	2	contrast	contrast	NOUN
hjic-110	200	3	,	,	PUNCT
hjic-110	200	4	when	when	SCONJ
hjic-110	200	5	solvent	solvent	NOUN
hjic-110	200	6	was	be	AUX
hjic-110	200	7	removed	remove	VERB
hjic-110	200	8	by	by	ADP
hjic-110	200	9	evaporation	evaporation	NOUN
hjic-110	200	10	pvp	pvp	NOUN
hjic-110	200	11	gave	give	VERB
hjic-110	200	12	a	a	DET
hjic-110	200	13	film	film	NOUN
hjic-110	200	14	-	-	PUNCT
hjic-110	200	15	like	like	ADJ
hjic-110	200	16	precipitate	precipitate	NOUN
hjic-110	200	17	wherein	wherein	ADJ
hjic-110	200	18	dispersed	disperse	VERB
hjic-110	200	19	drug	drug	NOUN
hjic-110	200	20	was	be	AUX
hjic-110	200	21	not	not	PART
hjic-110	200	22	distinguishable	distinguishable	ADJ
hjic-110	200	23	from	from	ADP
hjic-110	200	24	the	the	DET
hjic-110	200	25	excipient	excipient	ADJ
hjic-110	200	26	matrix	matrix	NOUN
hjic-110	200	27	in	in	ADP
hjic-110	200	28	sem	sem	NOUN
hjic-110	200	29	micrographs	micrograph	NOUN
hjic-110	200	30	.	.	PUNCT
hjic-110	201	1	the	the	DET
hjic-110	201	2	physical	physical	ADJ
hjic-110	201	3	state	state	NOUN
hjic-110	201	4	of	of	ADP
hjic-110	201	5	each	each	DET
hjic-110	201	6	drug	drug	NOUN
hjic-110	201	7	-	-	PUNCT
hjic-110	201	8	carrier	carrier	NOUN
hjic-110	201	9	formulation	formulation	NOUN
hjic-110	201	10	was	be	AUX
hjic-110	201	11	investigated	investigate	VERB
hjic-110	201	12	by	by	ADP
hjic-110	201	13	xrd	xrd	NOUN
hjic-110	201	14	measurements	measurement	NOUN
hjic-110	201	15	.	.	PUNCT
hjic-110	202	1	the	the	DET
hjic-110	202	2	highintensity	highintensity	NOUN
hjic-110	202	3	diffraction	diffraction	NOUN
hjic-110	202	4	peaks	peak	NOUN
hjic-110	202	5	of	of	ADP
hjic-110	202	6	oxeglitazar	oxeglitazar	NOUN
hjic-110	202	7	(	(	PUNCT
hjic-110	202	8	form	form	NOUN
hjic-110	202	9	a	a	NOUN
hjic-110	202	10	)	)	PUNCT
hjic-110	202	11	at	at	ADP
hjic-110	202	12	d	d	NOUN
hjic-110	202	13	values	value	NOUN
hjic-110	202	14	of	of	ADP
hjic-110	202	15	15.26	15.26	NUM
hjic-110	202	16	,	,	PUNCT
hjic-110	202	17	8.45	8.45	NUM
hjic-110	202	18	,	,	PUNCT
hjic-110	202	19	5.39	5.39	NUM
hjic-110	202	20	and	and	CCONJ
hjic-110	202	21	4.23	4.23	NUM
hjic-110	202	22	å	å	NOUN
hjic-110	202	23	were	be	AUX
hjic-110	202	24	hardly	hardly	ADV
hjic-110	202	25	detectable	detectable	ADJ
hjic-110	202	26	in	in	ADP
hjic-110	202	27	solid	solid	ADJ
hjic-110	202	28	dispersions	dispersion	NOUN
hjic-110	202	29	.	.	PUNCT
hjic-110	203	1	consistently	consistently	ADV
hjic-110	203	2	with	with	ADP
hjic-110	203	3	previous	previous	ADJ
hjic-110	203	4	studies	study	NOUN
hjic-110	203	5	pvp	pvp	NOUN
hjic-110	203	6	has	have	AUX
hjic-110	203	7	successfully	successfully	ADV
hjic-110	203	8	inhibited	inhibit	VERB
hjic-110	203	9	the	the	DET
hjic-110	203	10	crystal	crystal	NOUN
hjic-110	203	11	growth	growth	NOUN
hjic-110	203	12	of	of	ADP
hjic-110	203	13	the	the	DET
hjic-110	203	14	active	active	ADJ
hjic-110	203	15	substance	substance	NOUN
hjic-110	203	16	[	[	X
hjic-110	203	17	10,11,45,46	10,11,45,46	NUM
hjic-110	203	18	]	]	PUNCT
hjic-110	203	19	while	while	SCONJ
hjic-110	203	20	,	,	PUNCT
hjic-110	203	21	poloxamer	poloxamer	PROPN
hjic-110	203	22	407	407	NUM
hjic-110	203	23	remained	remain	VERB
hjic-110	203	24	crystalline	crystalline	NOUN
hjic-110	203	25	after	after	ADP
hjic-110	203	26	the	the	DET
hjic-110	203	27	formulation	formulation	NOUN
hjic-110	203	28	process	process	NOUN
hjic-110	203	29	too	too	ADV
hjic-110	203	30	,	,	PUNCT
hjic-110	203	31	and	and	CCONJ
hjic-110	203	32	hence	hence	ADV
hjic-110	203	33	semi	semi	ADJ
hjic-110	203	34	-	-	ADJ
hjic-110	203	35	crystalline	crystalline	ADJ
hjic-110	203	36	solid	solid	ADJ
hjic-110	203	37	dispersions	dispersion	NOUN
hjic-110	203	38	were	be	AUX
hjic-110	203	39	obtained	obtain	VERB
hjic-110	203	40	instead	instead	ADV
hjic-110	203	41	of	of	ADP
hjic-110	203	42	solid	solid	ADJ
hjic-110	203	43	solutions	solution	NOUN
hjic-110	203	44	.	.	PUNCT
hjic-110	204	1	a	a	DET
hjic-110	204	2	comparison	comparison	NOUN
hjic-110	204	3	was	be	AUX
hjic-110	204	4	made	make	VERB
hjic-110	204	5	between	between	ADP
hjic-110	204	6	the	the	DET
hjic-110	204	7	drug	drug	NOUN
hjic-110	204	8	-	-	PUNCT
hjic-110	204	9	carrier	carrier	NOUN
hjic-110	204	10	formulations	formulation	NOUN
hjic-110	204	11	prepared	prepare	VERB
hjic-110	204	12	by	by	ADP
hjic-110	204	13	the	the	DET
hjic-110	204	14	two	two	NUM
hjic-110	204	15	methods	method	NOUN
hjic-110	204	16	.	.	PUNCT
hjic-110	205	1	characteristic	characteristic	ADJ
hjic-110	205	2	peaks	peak	NOUN
hjic-110	205	3	were	be	AUX
hjic-110	205	4	much	much	ADV
hjic-110	205	5	smaller	small	ADJ
hjic-110	205	6	for	for	ADP
hjic-110	205	7	coevaporates	coevaporate	NOUN
hjic-110	205	8	than	than	ADP
hjic-110	205	9	for	for	ADP
hjic-110	205	10	coprecipitates	coprecipitate	NOUN
hjic-110	205	11	using	use	VERB
hjic-110	205	12	the	the	DET
hjic-110	205	13	same	same	ADJ
hjic-110	205	14	polymer	polymer	NOUN
hjic-110	205	15	.	.	PUNCT
hjic-110	206	1	thus	thus	ADV
hjic-110	206	2	,	,	PUNCT
hjic-110	206	3	coevaporation	coevaporation	NOUN
hjic-110	206	4	seems	seem	VERB
hjic-110	206	5	to	to	PART
hjic-110	206	6	be	be	AUX
hjic-110	206	7	more	more	ADV
hjic-110	206	8	efficient	efficient	ADJ
hjic-110	206	9	in	in	ADP
hjic-110	206	10	the	the	DET
hjic-110	206	11	preparation	preparation	NOUN
hjic-110	206	12	of	of	ADP
hjic-110	206	13	oxeglitazar	oxeglitazar	NOUN
hjic-110	206	14	/	/	SYM
hjic-110	206	15	excipient	excipient	ADJ
hjic-110	206	16	solid	solid	ADJ
hjic-110	206	17	solutions	solution	NOUN
hjic-110	206	18	.	.	PUNCT
hjic-110	207	1	xrd	xrd	PROPN
hjic-110	207	2	was	be	AUX
hjic-110	207	3	also	also	ADV
hjic-110	207	4	used	use	VERB
hjic-110	207	5	to	to	PART
hjic-110	207	6	assess	assess	VERB
hjic-110	207	7	the	the	DET
hjic-110	207	8	polymorphic	polymorphic	ADJ
hjic-110	207	9	purity	purity	NOUN
hjic-110	207	10	of	of	ADP
hjic-110	207	11	formulations	formulation	NOUN
hjic-110	207	12	.	.	PUNCT
hjic-110	208	1	only	only	ADV
hjic-110	208	2	the	the	DET
hjic-110	208	3	form	form	NOUN
hjic-110	208	4	a	a	DET
hjic-110	208	5	(	(	PUNCT
hjic-110	208	6	thermodynamically	thermodynamically	ADV
hjic-110	208	7	stable	stable	ADJ
hjic-110	208	8	one	one	NOUN
hjic-110	208	9	)	)	PUNCT
hjic-110	208	10	was	be	AUX
hjic-110	208	11	present	present	ADJ
hjic-110	208	12	(	(	PUNCT
hjic-110	208	13	data	datum	NOUN
hjic-110	208	14	not	not	PART
hjic-110	208	15	shown	show	VERB
hjic-110	208	16	)	)	PUNCT
hjic-110	208	17	satisfying	satisfy	VERB
hjic-110	208	18	current	current	ADJ
hjic-110	208	19	requirements	requirement	NOUN
hjic-110	208	20	for	for	ADP
hjic-110	208	21	stable	stable	ADJ
hjic-110	208	22	polymorph	polymorph	NOUN
hjic-110	208	23	.	.	PUNCT
hjic-110	209	1	in	in	ADP
hjic-110	209	2	fact	fact	NOUN
hjic-110	209	3	,	,	PUNCT
hjic-110	209	4	the	the	DET
hjic-110	209	5	amorphous	amorphous	ADJ
hjic-110	209	6	form	form	NOUN
hjic-110	209	7	that	that	PRON
hjic-110	209	8	predominantly	predominantly	ADV
hjic-110	209	9	constitutes	constitute	VERB
hjic-110	209	10	the	the	DET
hjic-110	209	11	solid	solid	ADJ
hjic-110	209	12	dispersions	dispersion	NOUN
hjic-110	209	13	is	be	AUX
hjic-110	209	14	also	also	ADV
hjic-110	209	15	metastable	metastable	ADJ
hjic-110	209	16	above	above	ADP
hjic-110	209	17	or	or	CCONJ
hjic-110	209	18	near	near	ADP
hjic-110	209	19	the	the	DET
hjic-110	209	20	glass	glass	NOUN
hjic-110	209	21	transition	transition	NOUN
hjic-110	209	22	temperature	temperature	NOUN
hjic-110	209	23	.	.	PUNCT
hjic-110	210	1	the	the	DET
hjic-110	210	2	amorphous	amorphous	ADJ
hjic-110	210	3	to	to	ADP
hjic-110	210	4	crystalline	crystalline	NOUN
hjic-110	210	5	phase	phase	NOUN
hjic-110	210	6	transition	transition	NOUN
hjic-110	210	7	is	be	AUX
hjic-110	210	8	even	even	ADV
hjic-110	210	9	faster	fast	ADJ
hjic-110	210	10	if	if	SCONJ
hjic-110	210	11	micro	micro	ADJ
hjic-110	210	12	or	or	CCONJ
hjic-110	210	13	nano	nano	NOUN
hjic-110	210	14	-	-	NOUN
hjic-110	210	15	crystals	crystal	NOUN
hjic-110	210	16	are	be	AUX
hjic-110	210	17	present	present	ADJ
hjic-110	210	18	in	in	ADP
hjic-110	210	19	the	the	DET
hjic-110	210	20	formulation	formulation	NOUN
hjic-110	210	21	.	.	PUNCT
hjic-110	211	1	the	the	DET
hjic-110	211	2	use	use	NOUN
hjic-110	211	3	of	of	ADP
hjic-110	211	4	pharmaceutical	pharmaceutical	ADJ
hjic-110	211	5	excipients	excipient	NOUN
hjic-110	211	6	is	be	AUX
hjic-110	211	7	often	often	ADV
hjic-110	211	8	sufficient	sufficient	ADJ
hjic-110	211	9	to	to	PART
hjic-110	211	10	inhibit	inhibit	VERB
hjic-110	211	11	crystallization	crystallization	NOUN
hjic-110	211	12	and	and	CCONJ
hjic-110	211	13	improve	improve	VERB
hjic-110	211	14	long	long	ADJ
hjic-110	211	15	-	-	PUNCT
hjic-110	211	16	term	term	NOUN
hjic-110	211	17	stability	stability	NOUN
hjic-110	211	18	.	.	PUNCT
hjic-110	212	1	an	an	DET
hjic-110	212	2	amorphous	amorphous	ADJ
hjic-110	212	3	polymer	polymer	NOUN
hjic-110	212	4	matrix	matrix	NOUN
hjic-110	212	5	may	may	AUX
hjic-110	212	6	reduce	reduce	VERB
hjic-110	212	7	considerably	considerably	ADV
hjic-110	212	8	the	the	DET
hjic-110	212	9	molecular	molecular	ADJ
hjic-110	212	10	mobility	mobility	NOUN
hjic-110	212	11	of	of	ADP
hjic-110	212	12	the	the	DET
hjic-110	212	13	incorporated	incorporated	ADJ
hjic-110	212	14	api	api	NOUN
hjic-110	212	15	which	which	PRON
hjic-110	212	16	is	be	AUX
hjic-110	212	17	in	in	ADP
hjic-110	212	18	most	most	ADJ
hjic-110	212	19	cases	case	NOUN
hjic-110	212	20	linked	link	VERB
hjic-110	212	21	by	by	ADP
hjic-110	212	22	weak	weak	ADJ
hjic-110	212	23	interactions	interaction	NOUN
hjic-110	212	24	such	such	ADJ
hjic-110	212	25	as	as	ADP
hjic-110	212	26	hydrogen	hydrogen	NOUN
hjic-110	212	27	bonding	bonding	NOUN
hjic-110	212	28	to	to	ADP
hjic-110	212	29	the	the	DET
hjic-110	212	30	polymer	polymer	NOUN
hjic-110	212	31	[	[	X
hjic-110	212	32	47,48	47,48	NOUN
hjic-110	212	33	]	]	SYM
hjic-110	212	34	.	.	PUNCT
hjic-110	213	1	ftir	ftir	PROPN
hjic-110	213	2	studies	study	NOUN
hjic-110	213	3	were	be	AUX
hjic-110	213	4	performed	perform	VERB
hjic-110	213	5	in	in	ADP
hjic-110	213	6	order	order	NOUN
hjic-110	213	7	to	to	PART
hjic-110	213	8	detect	detect	VERB
hjic-110	213	9	possible	possible	ADJ
hjic-110	213	10	hydrogen	hydrogen	NOUN
hjic-110	213	11	bonding	bonding	NOUN
hjic-110	213	12	interactions	interaction	NOUN
hjic-110	213	13	.	.	PUNCT
hjic-110	214	1	such	such	ADJ
hjic-110	214	2	interaction	interaction	NOUN
hjic-110	214	3	was	be	AUX
hjic-110	214	4	not	not	PART
hjic-110	214	5	found	find	VERB
hjic-110	214	6	in	in	ADP
hjic-110	214	7	either	either	CCONJ
hjic-110	214	8	physical	physical	ADJ
hjic-110	214	9	mixture	mixture	NOUN
hjic-110	214	10	according	accord	VERB
hjic-110	214	11	to	to	ADP
hjic-110	214	12	our	our	PRON
hjic-110	214	13	expectations	expectation	NOUN
hjic-110	214	14	.	.	PUNCT
hjic-110	215	1	absorption	absorption	NOUN
hjic-110	215	2	bands	band	NOUN
hjic-110	215	3	have	have	AUX
hjic-110	215	4	simply	simply	ADV
hjic-110	215	5	superposed	superpose	VERB
hjic-110	215	6	when	when	SCONJ
hjic-110	215	7	pharmaceutical	pharmaceutical	ADJ
hjic-110	215	8	ingredients	ingredient	NOUN
hjic-110	215	9	were	be	AUX
hjic-110	215	10	mixed	mix	VERB
hjic-110	215	11	dry	dry	ADJ
hjic-110	215	12	.	.	PUNCT
hjic-110	216	1	in	in	ADP
hjic-110	216	2	the	the	DET
hjic-110	216	3	ftir	ftir	PROPN
hjic-110	216	4	spectra	spectra	NOUN
hjic-110	216	5	of	of	ADP
hjic-110	216	6	oxeglitazar	oxeglitazar	PROPN
hjic-110	216	7	/	/	SYM
hjic-110	216	8	pvp	pvp	PROPN
hjic-110	216	9	k17	k17	PROPN
hjic-110	216	10	solid	solid	ADJ
hjic-110	216	11	dispersions	dispersion	NOUN
hjic-110	216	12	the	the	DET
hjic-110	216	13	νc	νc	NOUN
hjic-110	216	14	=	=	NOUN
hjic-110	216	15	o	o	NOUN
hjic-110	216	16	band	band	NOUN
hjic-110	216	17	is	be	AUX
hjic-110	216	18	split	split	VERB
hjic-110	216	19	into	into	ADP
hjic-110	216	20	two	two	NUM
hjic-110	216	21	frequencies	frequency	NOUN
hjic-110	216	22	.	.	PUNCT
hjic-110	217	1	a	a	DET
hjic-110	217	2	new	new	ADJ
hjic-110	217	3	band	band	NOUN
hjic-110	217	4	seems	seem	VERB
hjic-110	217	5	to	to	PART
hjic-110	217	6	appear	appear	VERB
hjic-110	217	7	at	at	ADP
hjic-110	217	8	about	about	ADV
hjic-110	217	9	1650	1650	NUM
hjic-110	217	10	cm-1	cm-1	NOUN
hjic-110	217	11	beneath	beneath	ADP
hjic-110	217	12	the	the	DET
hjic-110	217	13	broad	broad	ADJ
hjic-110	217	14	absorption	absorption	NOUN
hjic-110	217	15	band	band	NOUN
hjic-110	217	16	of	of	ADP
hjic-110	217	17	physical	physical	ADJ
hjic-110	217	18	mixture	mixture	NOUN
hjic-110	217	19	at	at	ADP
hjic-110	217	20	1680	1680	NUM
hjic-110	217	21	cm-1	cm-1	NOUN
hjic-110	217	22	.	.	PUNCT
hjic-110	218	1	the	the	DET
hjic-110	218	2	shift	shift	NOUN
hjic-110	218	3	of	of	ADP
hjic-110	218	4	carbonyl	carbonyl	NOUN
hjic-110	218	5	stretching	stretch	VERB
hjic-110	218	6	band	band	NOUN
hjic-110	218	7	to	to	ADP
hjic-110	218	8	higher	high	ADJ
hjic-110	218	9	frequency	frequency	NOUN
hjic-110	218	10	implies	imply	VERB
hjic-110	218	11	its	its	PRON
hjic-110	218	12	engagement	engagement	NOUN
hjic-110	218	13	in	in	ADP
hjic-110	218	14	hydrogen	hydrogen	NOUN
hjic-110	218	15	bonding	bonding	NOUN
hjic-110	218	16	with	with	ADP
hjic-110	218	17	the	the	DET
hjic-110	218	18	only	only	ADJ
hjic-110	218	19	hydrogen	hydrogen	NOUN
hjic-110	218	20	donor	donor	NOUN
hjic-110	218	21	group	group	NOUN
hjic-110	218	22	,	,	PUNCT
hjic-110	218	23	the	the	DET
hjic-110	218	24	carboxylic	carboxylic	ADJ
hjic-110	218	25	oh	oh	INTJ
hjic-110	218	26	of	of	ADP
hjic-110	218	27	oxeglitazar	oxeglitazar	NOUN
hjic-110	218	28	.	.	PUNCT
hjic-110	219	1	such	such	ADJ
hjic-110	219	2	interactions	interaction	NOUN
hjic-110	219	3	between	between	ADP
hjic-110	219	4	the	the	DET
hjic-110	219	5	carbonyl	carbonyl	NOUN
hjic-110	219	6	group	group	NOUN
hjic-110	219	7	of	of	ADP
hjic-110	219	8	pvp	pvp	PROPN
hjic-110	219	9	and	and	CCONJ
hjic-110	219	10	the	the	DET
hjic-110	219	11	carboxylic	carboxylic	ADJ
hjic-110	219	12	oh	oh	INTJ
hjic-110	219	13	of	of	ADP
hjic-110	219	14	another	another	DET
hjic-110	219	15	molecule	molecule	NOUN
hjic-110	219	16	was	be	AUX
hjic-110	219	17	previously	previously	ADV
hjic-110	219	18	reported	report	VERB
hjic-110	219	19	[	[	X
hjic-110	219	20	11,40,46	11,40,46	X
hjic-110	219	21	]	]	X
hjic-110	219	22	.	.	PUNCT
hjic-110	220	1	in	in	ADP
hjic-110	220	2	the	the	DET
hjic-110	220	3	case	case	NOUN
hjic-110	220	4	of	of	ADP
hjic-110	220	5	poloxamer	poloxamer	PROPN
hjic-110	220	6	407	407	NUM
hjic-110	220	7	,	,	PUNCT
hjic-110	220	8	possible	possible	ADJ
hjic-110	220	9	hydrogen	hydrogen	NOUN
hjic-110	220	10	bonding	bonding	NOUN
hjic-110	220	11	could	could	AUX
hjic-110	220	12	be	be	AUX
hjic-110	220	13	expected	expect	VERB
hjic-110	220	14	between	between	ADP
hjic-110	220	15	the	the	DET
hjic-110	220	16	carboxylic	carboxylic	ADJ
hjic-110	220	17	oh	oh	INTJ
hjic-110	220	18	of	of	ADP
hjic-110	220	19	the	the	DET
hjic-110	220	20	drug	drug	NOUN
hjic-110	220	21	and	and	CCONJ
hjic-110	220	22	the	the	DET
hjic-110	220	23	ether	ether	ADJ
hjic-110	220	24	oxygen	oxygen	NOUN
hjic-110	220	25	of	of	ADP
hjic-110	220	26	the	the	DET
hjic-110	220	27	polymer	polymer	NOUN
hjic-110	220	28	,	,	PUNCT
hjic-110	220	29	or	or	CCONJ
hjic-110	220	30	between	between	ADP
hjic-110	220	31	the	the	DET
hjic-110	220	32	terminal	terminal	ADJ
hjic-110	220	33	oh	oh	INTJ
hjic-110	220	34	of	of	ADP
hjic-110	220	35	poloxamer	poloxamer	PROPN
hjic-110	220	36	and	and	CCONJ
hjic-110	220	37	one	one	NUM
hjic-110	220	38	hydrogen	hydrogen	NOUN
hjic-110	220	39	acceptor	acceptor	NOUN
hjic-110	220	40	group	group	NOUN
hjic-110	220	41	of	of	ADP
hjic-110	220	42	oxeglitazar	oxeglitazar	NOUN
hjic-110	220	43	.	.	PUNCT
hjic-110	221	1	however	however	ADV
hjic-110	221	2	,	,	PUNCT
hjic-110	221	3	ftir	ftir	PROPN
hjic-110	221	4	studies	study	NOUN
hjic-110	221	5	showed	show	VERB
hjic-110	221	6	no	no	DET
hjic-110	221	7	evidence	evidence	NOUN
hjic-110	221	8	of	of	ADP
hjic-110	221	9	such	such	ADJ
hjic-110	221	10	interactions	interaction	NOUN
hjic-110	221	11	.	.	PUNCT
hjic-110	222	1	the	the	DET
hjic-110	222	2	spectra	spectra	NOUN
hjic-110	222	3	of	of	ADP
hjic-110	222	4	oxeglitazar	oxeglitazar	PROPN
hjic-110	222	5	/	/	SYM
hjic-110	222	6	poloxamer	poloxamer	NOUN
hjic-110	222	7	407	407	NUM
hjic-110	222	8	solid	solid	ADJ
hjic-110	222	9	dispersions	dispersion	NOUN
hjic-110	222	10	were	be	AUX
hjic-110	222	11	virtually	virtually	ADV
hjic-110	222	12	identical	identical	ADJ
hjic-110	222	13	to	to	ADP
hjic-110	222	14	that	that	PRON
hjic-110	222	15	of	of	ADP
hjic-110	222	16	physical	physical	ADJ
hjic-110	222	17	mixture	mixture	NOUN
hjic-110	222	18	.	.	PUNCT
hjic-110	223	1	gc	gc	PROPN
hjic-110	223	2	analysis	analysis	NOUN
hjic-110	223	3	revealed	reveal	VERB
hjic-110	223	4	that	that	SCONJ
hjic-110	223	5	residual	residual	ADJ
hjic-110	223	6	dcm	dcm	PROPN
hjic-110	223	7	content	content	NOUN
hjic-110	223	8	in	in	ADP
hjic-110	223	9	oxeglitazar	oxeglitazar	NOUN
hjic-110	223	10	/	/	SYM
hjic-110	223	11	poloxamer	poloxamer	NOUN
hjic-110	223	12	407	407	NUM
hjic-110	223	13	formulations	formulation	NOUN
hjic-110	223	14	met	meet	VERB
hjic-110	223	15	recommended	recommend	VERB
hjic-110	223	16	limits	limit	NOUN
hjic-110	223	17	under	under	ADP
hjic-110	223	18	option	option	NOUN
hjic-110	223	19	2	2	NUM
hjic-110	223	20	and	and	CCONJ
hjic-110	223	21	it	it	PRON
hjic-110	223	22	can	can	AUX
hjic-110	223	23	be	be	AUX
hjic-110	223	24	easily	easily	ADV
hjic-110	223	25	reduced	reduce	VERB
hjic-110	223	26	below	below	ADP
hjic-110	223	27	option	option	NOUN
hjic-110	223	28	1	1	NUM
hjic-110	223	29	limit	limit	NOUN
hjic-110	223	30	by	by	ADP
hjic-110	223	31	vacuum	vacuum	NOUN
hjic-110	223	32	drying	dry	VERB
hjic-110	223	33	[	[	X
hjic-110	223	34	43	43	NUM
hjic-110	223	35	]	]	PUNCT
hjic-110	223	36	.	.	PUNCT
hjic-110	224	1	unlike	unlike	ADP
hjic-110	224	2	the	the	DET
hjic-110	224	3	crystalline	crystalline	ADJ
hjic-110	224	4	poloxamer	poloxamer	NOUN
hjic-110	224	5	407	407	NUM
hjic-110	224	6	,	,	PUNCT
hjic-110	224	7	the	the	DET
hjic-110	224	8	oxeglitazar	oxeglitazar	NOUN
hjic-110	224	9	/	/	SYM
hjic-110	224	10	pvp	pvp	PROPN
hjic-110	224	11	k17	k17	PROPN
hjic-110	224	12	coprecipitate	coprecipitate	PROPN
hjic-110	224	13	and	and	CCONJ
hjic-110	224	14	coevaporate	coevaporate	NOUN
hjic-110	224	15	exceeded	exceed	VERB
hjic-110	224	16	the	the	DET
hjic-110	224	17	higher	high	ADJ
hjic-110	224	18	option	option	NOUN
hjic-110	224	19	2	2	NUM
hjic-110	224	20	limit	limit	NOUN
hjic-110	224	21	and	and	CCONJ
hjic-110	224	22	formulations	formulation	NOUN
hjic-110	224	23	did	do	AUX
hjic-110	224	24	not	not	PART
hjic-110	224	25	meet	meet	VERB
hjic-110	224	26	option	option	NOUN
hjic-110	224	27	1	1	NUM
hjic-110	224	28	limit	limit	NOUN
hjic-110	224	29	even	even	ADV
hjic-110	224	30	after	after	ADP
hjic-110	224	31	drying	dry	VERB
hjic-110	224	32	for	for	ADP
hjic-110	224	33	24	24	NUM
hjic-110	224	34	h.	h.	NOUN
hjic-110	224	35	the	the	DET
hjic-110	224	36	main	main	ADJ
hjic-110	224	37	drawback	drawback	NOUN
hjic-110	224	38	of	of	ADP
hjic-110	224	39	48	48	NUM
hjic-110	224	40	coevaporation	coevaporation	NOUN
hjic-110	224	41	is	be	AUX
hjic-110	224	42	that	that	SCONJ
hjic-110	224	43	solvent	solvent	ADJ
hjic-110	224	44	traces	trace	NOUN
hjic-110	224	45	get	get	AUX
hjic-110	224	46	trapped	trap	VERB
hjic-110	224	47	in	in	ADP
hjic-110	224	48	the	the	DET
hjic-110	224	49	amorphous	amorphous	ADJ
hjic-110	224	50	solid	solid	ADJ
hjic-110	224	51	dispersion	dispersion	NOUN
hjic-110	224	52	and	and	CCONJ
hjic-110	224	53	further	far	ADV
hjic-110	224	54	drying	dry	VERB
hjic-110	224	55	process	process	NOUN
hjic-110	224	56	is	be	AUX
hjic-110	224	57	needed	need	VERB
hjic-110	224	58	.	.	PUNCT
hjic-110	225	1	coevaporates	coevaporate	NOUN
hjic-110	225	2	were	be	AUX
hjic-110	225	3	left	leave	VERB
hjic-110	225	4	in	in	ADP
hjic-110	225	5	the	the	DET
hjic-110	225	6	rota	rota	NOUN
hjic-110	225	7	-	-	PUNCT
hjic-110	225	8	dest	dest	ADJ
hjic-110	225	9	apparatus	apparatus	NOUN
hjic-110	225	10	for	for	ADP
hjic-110	225	11	2	2	NUM
hjic-110	225	12	h	h	NOUN
hjic-110	225	13	,	,	PUNCT
hjic-110	225	14	the	the	DET
hjic-110	225	15	time	time	NOUN
hjic-110	225	16	that	that	PRON
hjic-110	225	17	a	a	DET
hjic-110	225	18	typical	typical	ADJ
hjic-110	225	19	sas	sas	PROPN
hjic-110	225	20	process	process	NOUN
hjic-110	225	21	has	have	AUX
hjic-110	225	22	taken	take	VERB
hjic-110	225	23	,	,	PUNCT
hjic-110	225	24	even	even	ADV
hjic-110	225	25	though	though	SCONJ
hjic-110	225	26	dcm	dcm	PROPN
hjic-110	225	27	had	have	AUX
hjic-110	225	28	evaporated	evaporate	VERB
hjic-110	225	29	within	within	ADP
hjic-110	225	30	a	a	DET
hjic-110	225	31	few	few	ADJ
hjic-110	225	32	minutes	minute	NOUN
hjic-110	225	33	.	.	PUNCT
hjic-110	226	1	thus	thus	ADV
hjic-110	226	2	residual	residual	ADJ
hjic-110	226	3	solvent	solvent	ADJ
hjic-110	226	4	contents	content	NOUN
hjic-110	226	5	in	in	ADP
hjic-110	226	6	coprecipitate	coprecipitate	NOUN
hjic-110	226	7	and	and	CCONJ
hjic-110	226	8	coevaporate	coevaporate	VERB
hjic-110	226	9	are	be	AUX
hjic-110	226	10	comparable	comparable	ADJ
hjic-110	226	11	.	.	PUNCT
hjic-110	227	1	residual	residual	ADJ
hjic-110	227	2	dcm	dcm	PROPN
hjic-110	227	3	contents	content	NOUN
hjic-110	227	4	were	be	AUX
hjic-110	227	5	consistent	consistent	ADJ
hjic-110	227	6	with	with	ADP
hjic-110	227	7	published	publish	VERB
hjic-110	227	8	works	work	NOUN
hjic-110	227	9	on	on	ADP
hjic-110	227	10	scf	scf	PROPN
hjic-110	227	11	processed	process	VERB
hjic-110	227	12	pharmaceutical	pharmaceutical	NOUN
hjic-110	227	13	products	product	NOUN
hjic-110	227	14	.	.	PUNCT
hjic-110	228	1	bitz	bitz	PROPN
hjic-110	228	2	and	and	CCONJ
hjic-110	228	3	doelker	doelker	NOUN
hjic-110	228	4	compared	compare	VERB
hjic-110	228	5	spray	spray	NOUN
hjic-110	228	6	-	-	PUNCT
hjic-110	228	7	drying	dry	VERB
hjic-110	228	8	,	,	PUNCT
hjic-110	228	9	solvent	solvent	ADJ
hjic-110	228	10	evaporation	evaporation	NOUN
hjic-110	228	11	and	and	CCONJ
hjic-110	228	12	ases	as	NOUN
hjic-110	228	13	processes	process	VERB
hjic-110	228	14	[	[	X
hjic-110	228	15	13	13	NUM
hjic-110	228	16	]	]	PUNCT
hjic-110	228	17	.	.	PUNCT
hjic-110	229	1	residual	residual	ADJ
hjic-110	229	2	dcm	dcm	PROPN
hjic-110	229	3	concentrations	concentration	NOUN
hjic-110	229	4	in	in	ADP
hjic-110	229	5	l	l	ADJ
hjic-110	229	6	-	-	ADJ
hjic-110	229	7	poly(lactic	poly(lactic	ADJ
hjic-110	229	8	acid	acid	NOUN
hjic-110	229	9	)	)	PUNCT
hjic-110	229	10	(	(	PUNCT
hjic-110	229	11	l	l	NOUN
hjic-110	229	12	-	-	NOUN
hjic-110	229	13	pla	pla	NOUN
hjic-110	229	14	)	)	PUNCT
hjic-110	229	15	and	and	CCONJ
hjic-110	229	16	l	l	NOUN
hjic-110	229	17	-	-	NOUN
hjic-110	229	18	pla	pla	ADJ
hjic-110	229	19	/	/	SYM
hjic-110	229	20	tetracosactide	tetracosactide	NOUN
hjic-110	229	21	powders	powder	NOUN
hjic-110	229	22	after	after	ADP
hjic-110	229	23	4	4	NUM
hjic-110	229	24	hours	hour	NOUN
hjic-110	229	25	of	of	ADP
hjic-110	229	26	solvent	solvent	NOUN
hjic-110	229	27	stripping	stripping	NOUN
hjic-110	229	28	were	be	AUX
hjic-110	229	29	5283	5283	NUM
hjic-110	229	30	and	and	CCONJ
hjic-110	229	31	758.3	758.3	NUM
hjic-110	229	32	ppm	ppm	NOUN
hjic-110	229	33	,	,	PUNCT
hjic-110	229	34	respectively	respectively	ADV
hjic-110	229	35	.	.	PUNCT
hjic-110	230	1	powders	powder	NOUN
hjic-110	230	2	were	be	AUX
hjic-110	230	3	further	far	ADV
hjic-110	230	4	dried	dry	VERB
hjic-110	230	5	under	under	ADP
hjic-110	230	6	reduced	reduce	VERB
hjic-110	230	7	pressure	pressure	NOUN
hjic-110	230	8	for	for	ADP
hjic-110	230	9	3	3	NUM
hjic-110	230	10	day	day	NOUN
hjic-110	230	11	after	after	ADP
hjic-110	230	12	which	which	PRON
hjic-110	230	13	residual	residual	ADJ
hjic-110	230	14	dcm	dcm	NOUN
hjic-110	230	15	contents	content	NOUN
hjic-110	230	16	decreased	decrease	VERB
hjic-110	230	17	below	below	ADP
hjic-110	230	18	6	6	NUM
hjic-110	230	19	ppm	ppm	NOUN
hjic-110	230	20	.	.	PUNCT
hjic-110	231	1	ruchatz	ruchatz	AUX
hjic-110	231	2	et	et	PROPN
hjic-110	231	3	al	al	PROPN
hjic-110	231	4	.	.	PROPN
hjic-110	231	5	studied	study	VERB
hjic-110	231	6	the	the	DET
hjic-110	231	7	effect	effect	NOUN
hjic-110	231	8	of	of	ADP
hjic-110	231	9	spraying	spray	VERB
hjic-110	231	10	rate	rate	NOUN
hjic-110	231	11	and	and	CCONJ
hjic-110	231	12	co2	co2	NOUN
hjic-110	231	13	flow	flow	NOUN
hjic-110	231	14	rate	rate	NOUN
hjic-110	231	15	on	on	ADP
hjic-110	231	16	the	the	DET
hjic-110	231	17	residual	residual	ADJ
hjic-110	231	18	solvent	solvent	NOUN
hjic-110	231	19	content	content	NOUN
hjic-110	231	20	,	,	PUNCT
hjic-110	231	21	particle	particle	NOUN
hjic-110	231	22	size	size	NOUN
hjic-110	231	23	,	,	PUNCT
hjic-110	231	24	yield	yield	NOUN
hjic-110	231	25	and	and	CCONJ
hjic-110	231	26	morphology	morphology	NOUN
hjic-110	231	27	of	of	ADP
hjic-110	231	28	ases	ases	PROPN
hjic-110	231	29	prepared	prepare	VERB
hjic-110	231	30	l	l	NOUN
hjic-110	231	31	-	-	NOUN
hjic-110	231	32	pla	pla	ADJ
hjic-110	231	33	particles	particle	NOUN
hjic-110	232	1	[	[	X
hjic-110	232	2	22	22	NUM
hjic-110	232	3	]	]	PUNCT
hjic-110	232	4	.	.	PUNCT
hjic-110	233	1	the	the	DET
hjic-110	233	2	authors	author	NOUN
hjic-110	233	3	achieved	achieve	VERB
hjic-110	233	4	low	low	ADJ
hjic-110	233	5	residual	residual	ADJ
hjic-110	233	6	concentrations	concentration	NOUN
hjic-110	233	7	of	of	ADP
hjic-110	233	8	dcm	dcm	PROPN
hjic-110	233	9	(	(	PUNCT
hjic-110	233	10	71.5	71.5	NUM
hjic-110	233	11	–	–	PUNCT
hjic-110	233	12	449.9	449.9	NUM
hjic-110	233	13	ppm	ppm	NOUN
hjic-110	233	14	)	)	PUNCT
hjic-110	233	15	after	after	ADP
hjic-110	233	16	5	5	NUM
hjic-110	233	17	hours	hour	NOUN
hjic-110	233	18	of	of	ADP
hjic-110	233	19	solvent	solvent	NOUN
hjic-110	233	20	stripping	strip	VERB
hjic-110	233	21	by	by	ADP
hjic-110	233	22	varying	vary	VERB
hjic-110	233	23	the	the	DET
hjic-110	233	24	co2	co2	NOUN
hjic-110	233	25	flow	flow	NOUN
hjic-110	233	26	rate	rate	NOUN
hjic-110	233	27	in	in	ADP
hjic-110	233	28	the	the	DET
hjic-110	233	29	range	range	NOUN
hjic-110	233	30	of	of	ADP
hjic-110	233	31	2	2	NUM
hjic-110	233	32	–	–	SYM
hjic-110	233	33	11	11	NUM
hjic-110	233	34	kg	kg	NOUN
hjic-110	233	35	/	/	SYM
hjic-110	233	36	h.	h.	NOUN
hjic-110	233	37	experiments	experiment	NOUN
hjic-110	233	38	,	,	PUNCT
hjic-110	233	39	carried	carry	VERB
hjic-110	233	40	out	out	ADP
hjic-110	233	41	at	at	ADP
hjic-110	233	42	constant	constant	ADJ
hjic-110	233	43	spraying	spraying	NOUN
hjic-110	233	44	rate	rate	NOUN
hjic-110	233	45	and	and	CCONJ
hjic-110	233	46	drying	dry	VERB
hjic-110	233	47	time	time	NOUN
hjic-110	233	48	revealed	reveal	VERB
hjic-110	233	49	that	that	SCONJ
hjic-110	233	50	residual	residual	ADJ
hjic-110	233	51	solvent	solvent	NOUN
hjic-110	233	52	level	level	NOUN
hjic-110	233	53	and	and	CCONJ
hjic-110	233	54	co2	co2	NOUN
hjic-110	233	55	flow	flow	NOUN
hjic-110	233	56	rate	rate	NOUN
hjic-110	233	57	were	be	AUX
hjic-110	233	58	inversely	inversely	ADV
hjic-110	233	59	proportional	proportional	ADJ
hjic-110	233	60	.	.	PUNCT
hjic-110	234	1	thus	thus	ADV
hjic-110	234	2	,	,	PUNCT
hjic-110	234	3	residual	residual	ADJ
hjic-110	234	4	solvent	solvent	NOUN
hjic-110	234	5	level	level	NOUN
hjic-110	234	6	can	can	AUX
hjic-110	234	7	be	be	AUX
hjic-110	234	8	reduced	reduce	VERB
hjic-110	234	9	by	by	ADP
hjic-110	234	10	increasing	increase	VERB
hjic-110	234	11	the	the	DET
hjic-110	234	12	co2	co2	NOUN
hjic-110	234	13	flow	flow	NOUN
hjic-110	234	14	rate	rate	NOUN
hjic-110	234	15	or	or	CCONJ
hjic-110	234	16	extending	extend	VERB
hjic-110	234	17	the	the	DET
hjic-110	234	18	solvent	solvent	NOUN
hjic-110	234	19	stripping	stripping	NOUN
hjic-110	234	20	.	.	PUNCT
hjic-110	235	1	among	among	ADP
hjic-110	235	2	the	the	DET
hjic-110	235	3	two	two	NUM
hjic-110	235	4	techniques	technique	NOUN
hjic-110	235	5	,	,	PUNCT
hjic-110	235	6	assessed	assess	VERB
hjic-110	235	7	in	in	ADP
hjic-110	235	8	this	this	DET
hjic-110	235	9	work	work	NOUN
hjic-110	235	10	,	,	PUNCT
hjic-110	235	11	sas	sas	PROPN
hjic-110	235	12	was	be	AUX
hjic-110	235	13	more	more	ADV
hjic-110	235	14	favorable	favorable	ADJ
hjic-110	235	15	in	in	ADP
hjic-110	235	16	terms	term	NOUN
hjic-110	235	17	of	of	ADP
hjic-110	235	18	residual	residual	ADJ
hjic-110	235	19	solvent	solvent	NOUN
hjic-110	235	20	content	content	NOUN
hjic-110	235	21	,	,	PUNCT
hjic-110	235	22	while	while	SCONJ
hjic-110	235	23	among	among	ADP
hjic-110	235	24	the	the	DET
hjic-110	235	25	excipients	excipient	NOUN
hjic-110	235	26	,	,	PUNCT
hjic-110	235	27	poloxamer	poloxamer	PROPN
hjic-110	235	28	407	407	NUM
hjic-110	235	29	was	be	AUX
hjic-110	235	30	proved	prove	VERB
hjic-110	235	31	to	to	PART
hjic-110	235	32	be	be	AUX
hjic-110	235	33	easier	easy	ADJ
hjic-110	235	34	to	to	PART
hjic-110	235	35	dry	dry	VERB
hjic-110	235	36	.	.	PUNCT
hjic-110	236	1	owing	owe	VERB
hjic-110	236	2	to	to	ADP
hjic-110	236	3	its	its	PRON
hjic-110	236	4	amorphous	amorphous	ADJ
hjic-110	236	5	state	state	NOUN
hjic-110	236	6	pvp	pvp	NOUN
hjic-110	236	7	has	have	VERB
hjic-110	236	8	a	a	DET
hjic-110	236	9	high	high	ADJ
hjic-110	236	10	tendency	tendency	NOUN
hjic-110	236	11	to	to	PART
hjic-110	236	12	retain	retain	VERB
hjic-110	236	13	solvent	solvent	NOUN
hjic-110	236	14	residues	residue	NOUN
hjic-110	236	15	during	during	ADP
hjic-110	236	16	the	the	DET
hjic-110	236	17	drying	drying	NOUN
hjic-110	236	18	or	or	CCONJ
hjic-110	236	19	solvent	solvent	ADJ
hjic-110	236	20	stripping	stripping	NOUN
hjic-110	236	21	process	process	NOUN
hjic-110	236	22	.	.	PUNCT
hjic-110	237	1	all	all	DET
hjic-110	237	2	drug	drug	NOUN
hjic-110	237	3	-	-	PUNCT
hjic-110	237	4	carrier	carrier	NOUN
hjic-110	237	5	formulations	formulation	NOUN
hjic-110	237	6	exhibited	exhibit	VERB
hjic-110	237	7	improved	improve	VERB
hjic-110	237	8	dissolution	dissolution	NOUN
hjic-110	237	9	properties	property	NOUN
hjic-110	237	10	that	that	PRON
hjic-110	237	11	allow	allow	VERB
hjic-110	237	12	more	more	ADJ
hjic-110	237	13	of	of	ADP
hjic-110	237	14	the	the	DET
hjic-110	237	15	drug	drug	NOUN
hjic-110	237	16	to	to	PART
hjic-110	237	17	be	be	AUX
hjic-110	237	18	absorbed	absorb	VERB
hjic-110	237	19	.	.	PUNCT
hjic-110	238	1	dissolved	dissolve	VERB
hjic-110	238	2	oxeglitazar	oxeglitazar	NOUN
hjic-110	238	3	from	from	ADP
hjic-110	238	4	poloxamer	poloxamer	NOUN
hjic-110	238	5	407	407	NUM
hjic-110	238	6	coprecipitate	coprecipitate	NOUN
hjic-110	238	7	and	and	CCONJ
hjic-110	238	8	coevaporate	coevaporate	VERB
hjic-110	238	9	at	at	ADP
hjic-110	238	10	5	5	NUM
hjic-110	238	11	min	min	NOUN
hjic-110	238	12	was	be	AUX
hjic-110	238	13	61.9	61.9	NUM
hjic-110	238	14	and	and	CCONJ
hjic-110	238	15	57.9	57.9	NUM
hjic-110	238	16	%	%	NOUN
hjic-110	238	17	,	,	PUNCT
hjic-110	238	18	respectively	respectively	ADV
hjic-110	238	19	.	.	PUNCT
hjic-110	239	1	the	the	DET
hjic-110	239	2	increase	increase	NOUN
hjic-110	239	3	in	in	ADP
hjic-110	239	4	dissolution	dissolution	ADJ
hjic-110	239	5	rate	rate	NOUN
hjic-110	239	6	was	be	AUX
hjic-110	239	7	roughly	roughly	ADV
hjic-110	239	8	two	two	NUM
hjic-110	239	9	-	-	ADJ
hjic-110	239	10	fold	fold	VERB
hjic-110	239	11	in	in	ADP
hjic-110	239	12	both	both	DET
hjic-110	239	13	formulations	formulation	NOUN
hjic-110	239	14	.	.	PUNCT
hjic-110	240	1	surprisingly	surprisingly	ADV
hjic-110	240	2	,	,	PUNCT
hjic-110	240	3	oxeglitazar	oxeglitazar	NOUN
hjic-110	240	4	/	/	SYM
hjic-110	240	5	pvp	pvp	PROPN
hjic-110	240	6	k17	k17	PROPN
hjic-110	240	7	solid	solid	ADJ
hjic-110	240	8	dispersions	dispersion	NOUN
hjic-110	240	9	showed	show	VERB
hjic-110	240	10	even	even	ADV
hjic-110	240	11	higher	high	ADJ
hjic-110	240	12	dissolution	dissolution	NOUN
hjic-110	240	13	rates	rate	NOUN
hjic-110	240	14	:	:	PUNCT
hjic-110	240	15	64.3	64.3	NUM
hjic-110	240	16	and	and	CCONJ
hjic-110	240	17	85.6	85.6	NUM
hjic-110	240	18	%	%	NOUN
hjic-110	240	19	of	of	ADP
hjic-110	240	20	the	the	DET
hjic-110	240	21	active	active	ADJ
hjic-110	240	22	substance	substance	NOUN
hjic-110	240	23	prepared	prepare	VERB
hjic-110	240	24	by	by	ADP
hjic-110	240	25	sas	sa	NOUN
hjic-110	240	26	and	and	CCONJ
hjic-110	240	27	coevaporation	coevaporation	NOUN
hjic-110	240	28	process	process	NOUN
hjic-110	240	29	were	be	AUX
hjic-110	240	30	dissolved	dissolve	VERB
hjic-110	240	31	within	within	ADP
hjic-110	240	32	5	5	NUM
hjic-110	240	33	min	min	NOUN
hjic-110	240	34	.	.	PUNCT
hjic-110	241	1	this	this	PRON
hjic-110	241	2	seems	seem	VERB
hjic-110	241	3	to	to	PART
hjic-110	241	4	be	be	AUX
hjic-110	241	5	contradictory	contradictory	ADJ
hjic-110	241	6	to	to	ADP
hjic-110	241	7	the	the	DET
hjic-110	241	8	results	result	NOUN
hjic-110	241	9	of	of	ADP
hjic-110	241	10	solubility	solubility	NOUN
hjic-110	241	11	studies	study	NOUN
hjic-110	241	12	.	.	PUNCT
hjic-110	242	1	the	the	DET
hjic-110	242	2	increase	increase	NOUN
hjic-110	242	3	in	in	ADP
hjic-110	242	4	oxeglitazar	oxeglitazar	NOUN
hjic-110	242	5	solubility	solubility	NOUN
hjic-110	242	6	was	be	AUX
hjic-110	242	7	more	more	ADJ
hjic-110	242	8	than	than	ADP
hjic-110	242	9	two	two	NUM
hjic-110	242	10	times	time	NOUN
hjic-110	242	11	higher	high	ADJ
hjic-110	242	12	for	for	ADP
hjic-110	242	13	poloxamer	poloxamer	NOUN
hjic-110	242	14	407	407	NUM
hjic-110	242	15	compared	compare	VERB
hjic-110	242	16	to	to	PART
hjic-110	242	17	pvp	pvp	VERB
hjic-110	242	18	k17	k17	PROPN
hjic-110	242	19	.	.	PUNCT
hjic-110	243	1	poloxamers	poloxamer	NOUN
hjic-110	243	2	are	be	AUX
hjic-110	243	3	highly	highly	ADV
hjic-110	243	4	water	water	ADJ
hjic-110	243	5	soluble	soluble	ADJ
hjic-110	243	6	amphiphilic	amphiphilic	ADJ
hjic-110	243	7	polymers	polymer	NOUN
hjic-110	243	8	that	that	PRON
hjic-110	243	9	form	form	VERB
hjic-110	243	10	micelles	micelle	NOUN
hjic-110	243	11	in	in	ADP
hjic-110	243	12	aqueous	aqueous	ADJ
hjic-110	243	13	media	medium	NOUN
hjic-110	243	14	and	and	CCONJ
hjic-110	243	15	stabilize	stabilize	VERB
hjic-110	243	16	dissolved	dissolved	ADJ
hjic-110	243	17	molecules	molecule	NOUN
hjic-110	243	18	or	or	CCONJ
hjic-110	243	19	nanoparticles	nanoparticle	NOUN
hjic-110	243	20	of	of	ADP
hjic-110	243	21	hydrophobic	hydrophobic	NOUN
hjic-110	243	22	apis	apis	ADJ
hjic-110	243	23	.	.	PUNCT
hjic-110	244	1	however	however	ADV
hjic-110	244	2	,	,	PUNCT
hjic-110	244	3	xrd	xrd	PROPN
hjic-110	244	4	measurements	measurement	NOUN
hjic-110	244	5	and	and	CCONJ
hjic-110	244	6	sem	sem	NOUN
hjic-110	244	7	micrographs	micrograph	NOUN
hjic-110	244	8	confirmed	confirm	VERB
hjic-110	244	9	that	that	SCONJ
hjic-110	244	10	poloxamer	poloxamer	PROPN
hjic-110	244	11	407	407	NUM
hjic-110	244	12	did	do	AUX
hjic-110	244	13	not	not	PART
hjic-110	244	14	form	form	VERB
hjic-110	244	15	a	a	DET
hjic-110	244	16	single	single	ADJ
hjic-110	244	17	phase	phase	NOUN
hjic-110	244	18	solution	solution	NOUN
hjic-110	244	19	with	with	ADP
hjic-110	244	20	oxeglitazar	oxeglitazar	NOUN
hjic-110	244	21	in	in	ADP
hjic-110	244	22	either	either	DET
hjic-110	244	23	process	process	NOUN
hjic-110	244	24	.	.	PUNCT
hjic-110	245	1	in	in	ADP
hjic-110	245	2	contrast	contrast	NOUN
hjic-110	245	3	,	,	PUNCT
hjic-110	245	4	pvp	pvp	PROPN
hjic-110	245	5	was	be	AUX
hjic-110	245	6	proved	prove	VERB
hjic-110	245	7	to	to	PART
hjic-110	245	8	be	be	AUX
hjic-110	245	9	suitable	suitable	ADJ
hjic-110	245	10	to	to	PART
hjic-110	245	11	prepare	prepare	VERB
hjic-110	245	12	molecularly	molecularly	ADV
hjic-110	245	13	dispersed	disperse	VERB
hjic-110	245	14	drug	drug	NOUN
hjic-110	245	15	-	-	PUNCT
hjic-110	245	16	carrier	carrier	NOUN
hjic-110	245	17	systems	system	NOUN
hjic-110	245	18	.	.	PUNCT
hjic-110	246	1	the	the	DET
hjic-110	246	2	dissolution	dissolution	NOUN
hjic-110	246	3	of	of	ADP
hjic-110	246	4	oxeglitazar	oxeglitazar	NOUN
hjic-110	246	5	/	/	SYM
hjic-110	246	6	pvp	pvp	NOUN
hjic-110	246	7	solid	solid	ADJ
hjic-110	246	8	dispersion	dispersion	NOUN
hjic-110	246	9	is	be	AUX
hjic-110	246	10	governed	govern	VERB
hjic-110	246	11	by	by	ADP
hjic-110	246	12	the	the	DET
hjic-110	246	13	disintegration	disintegration	NOUN
hjic-110	246	14	of	of	ADP
hjic-110	246	15	the	the	DET
hjic-110	246	16	polymer	polymer	NOUN
hjic-110	246	17	matrix	matrix	NOUN
hjic-110	246	18	which	which	PRON
hjic-110	246	19	was	be	AUX
hjic-110	246	20	found	find	VERB
hjic-110	246	21	to	to	PART
hjic-110	246	22	be	be	AUX
hjic-110	246	23	very	very	ADV
hjic-110	246	24	fast	fast	ADJ
hjic-110	246	25	.	.	PUNCT
hjic-110	247	1	although	although	SCONJ
hjic-110	247	2	,	,	PUNCT
hjic-110	247	3	poloxamer	poloxamer	PROPN
hjic-110	247	4	407	407	NUM
hjic-110	247	5	exhibited	exhibit	VERB
hjic-110	247	6	better	well	ADJ
hjic-110	247	7	drug	drug	NOUN
hjic-110	247	8	solubilizing	solubilize	VERB
hjic-110	247	9	properties	property	NOUN
hjic-110	247	10	,	,	PUNCT
hjic-110	247	11	the	the	DET
hjic-110	247	12	absorption	absorption	NOUN
hjic-110	247	13	of	of	ADP
hjic-110	247	14	an	an	DET
hjic-110	247	15	orally	orally	ADV
hjic-110	247	16	administered	administer	VERB
hjic-110	247	17	drug	drug	NOUN
hjic-110	247	18	is	be	AUX
hjic-110	247	19	governed	govern	VERB
hjic-110	247	20	by	by	ADP
hjic-110	247	21	kinetic	kinetic	NOUN
hjic-110	247	22	rather	rather	ADV
hjic-110	247	23	than	than	ADP
hjic-110	247	24	thermodynamic	thermodynamic	ADJ
hjic-110	247	25	factors	factor	NOUN
hjic-110	247	26	.	.	PUNCT
hjic-110	248	1	in	in	ADP
hjic-110	248	2	addition	addition	NOUN
hjic-110	248	3	to	to	ADP
hjic-110	248	4	better	well	ADJ
hjic-110	248	5	dissolution	dissolution	NOUN
hjic-110	248	6	kinetics	kinetic	NOUN
hjic-110	248	7	,	,	PUNCT
hjic-110	248	8	oxeglitazar	oxeglitazar	NOUN
hjic-110	248	9	/	/	SYM
hjic-110	248	10	pvp	pvp	PROPN
hjic-110	248	11	k17	k17	PROPN
hjic-110	248	12	solid	solid	ADJ
hjic-110	248	13	dispersions	dispersion	NOUN
hjic-110	248	14	are	be	AUX
hjic-110	248	15	expected	expect	VERB
hjic-110	248	16	to	to	PART
hjic-110	248	17	be	be	AUX
hjic-110	248	18	more	more	ADV
hjic-110	248	19	stable	stable	ADJ
hjic-110	248	20	due	due	ADP
hjic-110	248	21	to	to	ADP
hjic-110	248	22	the	the	DET
hjic-110	248	23	hydrogen	hydrogen	NOUN
hjic-110	248	24	bonding	bonding	NOUN
hjic-110	248	25	revealed	reveal	VERB
hjic-110	248	26	by	by	ADP
hjic-110	248	27	ftir	ftir	PROPN
hjic-110	248	28	studies	study	NOUN
hjic-110	248	29	.	.	PUNCT
hjic-110	249	1	on	on	ADP
hjic-110	249	2	the	the	DET
hjic-110	249	3	other	other	ADJ
hjic-110	249	4	hand	hand	NOUN
hjic-110	249	5	,	,	PUNCT
hjic-110	249	6	residual	residual	ADJ
hjic-110	249	7	solvent	solvent	NOUN
hjic-110	249	8	contents	content	NOUN
hjic-110	249	9	were	be	AUX
hjic-110	249	10	much	much	ADV
hjic-110	249	11	lower	low	ADJ
hjic-110	249	12	in	in	ADP
hjic-110	249	13	oxeglitazar	oxeglitazar	NOUN
hjic-110	249	14	/	/	SYM
hjic-110	249	15	poloxamer	poloxamer	NOUN
hjic-110	249	16	407	407	NUM
hjic-110	249	17	formulations	formulation	NOUN
hjic-110	249	18	.	.	PUNCT
hjic-110	250	1	the	the	DET
hjic-110	250	2	concentration	concentration	NOUN
hjic-110	250	3	of	of	ADP
hjic-110	250	4	dcm	dcm	PROPN
hjic-110	250	5	was	be	AUX
hjic-110	250	6	below	below	ADP
hjic-110	250	7	the	the	DET
hjic-110	250	8	option	option	NOUN
hjic-110	250	9	1	1	NUM
hjic-110	250	10	limit	limit	NOUN
hjic-110	250	11	after	after	ADP
hjic-110	250	12	24	24	NUM
hjic-110	250	13	h	h	NOUN
hjic-110	250	14	drying	dry	VERB
hjic-110	250	15	.	.	PUNCT
hjic-110	251	1	among	among	ADP
hjic-110	251	2	the	the	DET
hjic-110	251	3	two	two	NUM
hjic-110	251	4	techniques	technique	NOUN
hjic-110	251	5	sas	sa	NOUN
hjic-110	251	6	was	be	AUX
hjic-110	251	7	found	find	VERB
hjic-110	251	8	to	to	PART
hjic-110	251	9	be	be	AUX
hjic-110	251	10	more	more	ADV
hjic-110	251	11	efficient	efficient	ADJ
hjic-110	251	12	in	in	ADP
hjic-110	251	13	residual	residual	ADJ
hjic-110	251	14	solvent	solvent	NOUN
hjic-110	251	15	removal	removal	NOUN
hjic-110	251	16	.	.	PUNCT
hjic-110	252	1	dcm	dcm	PROPN
hjic-110	252	2	concentrations	concentration	NOUN
hjic-110	252	3	were	be	AUX
hjic-110	252	4	38	38	NUM
hjic-110	252	5	%	%	NOUN
hjic-110	252	6	lower	low	ADJ
hjic-110	252	7	for	for	ADP
hjic-110	252	8	oxeglitazar	oxeglitazar	NOUN
hjic-110	252	9	/	/	SYM
hjic-110	252	10	poloxamer	poloxamer	NOUN
hjic-110	252	11	407	407	NUM
hjic-110	252	12	coprecipitate	coprecipitate	NOUN
hjic-110	252	13	and	and	CCONJ
hjic-110	252	14	28	28	NUM
hjic-110	252	15	%	%	NOUN
hjic-110	252	16	lower	low	ADJ
hjic-110	252	17	for	for	ADP
hjic-110	252	18	oxeglitazar	oxeglitazar	NOUN
hjic-110	252	19	/	/	SYM
hjic-110	252	20	pvp	pvp	PROPN
hjic-110	252	21	k17	k17	PROPN
hjic-110	252	22	coprecipitate	coprecipitate	PROPN
hjic-110	252	23	than	than	ADP
hjic-110	252	24	for	for	ADP
hjic-110	252	25	corresponding	correspond	VERB
hjic-110	252	26	coevaporates	coevaporate	NOUN
hjic-110	252	27	.	.	PUNCT
hjic-110	253	1	conclusions	conclusion	NOUN
hjic-110	253	2	supercritical	supercritical	ADJ
hjic-110	253	3	antisolvent	antisolvent	NOUN
hjic-110	253	4	and	and	CCONJ
hjic-110	253	5	coevaporation	coevaporation	NOUN
hjic-110	253	6	techniques	technique	NOUN
hjic-110	253	7	were	be	AUX
hjic-110	253	8	evaluated	evaluate	VERB
hjic-110	253	9	for	for	ADP
hjic-110	253	10	their	their	PRON
hjic-110	253	11	potential	potential	ADJ
hjic-110	253	12	use	use	NOUN
hjic-110	253	13	in	in	ADP
hjic-110	253	14	the	the	DET
hjic-110	253	15	preparation	preparation	NOUN
hjic-110	253	16	of	of	ADP
hjic-110	253	17	immediate	immediate	ADJ
hjic-110	253	18	release	release	NOUN
hjic-110	253	19	solid	solid	ADJ
hjic-110	253	20	oral	oral	ADJ
hjic-110	253	21	dosage	dosage	NOUN
hjic-110	253	22	forms	form	NOUN
hjic-110	253	23	.	.	PUNCT
hjic-110	254	1	solid	solid	ADJ
hjic-110	254	2	dispersions	dispersion	NOUN
hjic-110	254	3	of	of	ADP
hjic-110	254	4	oxeglitazar	oxeglitazar	NOUN
hjic-110	254	5	in	in	ADP
hjic-110	254	6	poloxamer	poloxamer	PROPN
hjic-110	254	7	407	407	NUM
hjic-110	254	8	and	and	CCONJ
hjic-110	254	9	pvp	pvp	PROPN
hjic-110	254	10	k17	k17	PROPN
hjic-110	254	11	were	be	AUX
hjic-110	254	12	prepared	prepare	VERB
hjic-110	254	13	and	and	CCONJ
hjic-110	254	14	characterized	characterize	VERB
hjic-110	254	15	by	by	ADP
hjic-110	254	16	powder	powder	NOUN
hjic-110	254	17	x	x	NOUN
hjic-110	254	18	-	-	NOUN
hjic-110	254	19	ray	ray	NOUN
hjic-110	254	20	diffraction	diffraction	NOUN
hjic-110	254	21	,	,	PUNCT
hjic-110	254	22	fourier	fourier	NOUN
hjic-110	254	23	transform	transform	VERB
hjic-110	254	24	infrared	infrared	ADJ
hjic-110	254	25	spectroscopy	spectroscopy	NOUN
hjic-110	254	26	,	,	PUNCT
hjic-110	254	27	scanning	scan	VERB
hjic-110	254	28	electron	electron	NOUN
hjic-110	254	29	microscopy	microscopy	NOUN
hjic-110	254	30	,	,	PUNCT
hjic-110	254	31	gas	gas	NOUN
hjic-110	254	32	chromatography	chromatography	NOUN
hjic-110	254	33	,	,	PUNCT
hjic-110	254	34	uv	uv	NOUN
hjic-110	254	35	/	/	SYM
hjic-110	254	36	vis	vis	X
hjic-110	254	37	spectroscopy	spectroscopy	NOUN
hjic-110	254	38	and	and	CCONJ
hjic-110	254	39	in	in	ADP
hjic-110	254	40	vitro	vitro	X
hjic-110	254	41	dissolution	dissolution	NOUN
hjic-110	254	42	tests	test	NOUN
hjic-110	254	43	.	.	PUNCT
hjic-110	255	1	solid	solid	ADJ
hjic-110	255	2	dispersions	dispersion	NOUN
hjic-110	255	3	obtained	obtain	VERB
hjic-110	255	4	in	in	ADP
hjic-110	255	5	both	both	DET
hjic-110	255	6	techniques	technique	NOUN
hjic-110	255	7	were	be	AUX
hjic-110	255	8	poorly	poorly	ADV
hjic-110	255	9	crystalline	crystalline	ADJ
hjic-110	255	10	and	and	CCONJ
hjic-110	255	11	dissolved	dissolve	VERB
hjic-110	255	12	quickly	quickly	ADV
hjic-110	255	13	in	in	ADP
hjic-110	255	14	ph	ph	ADJ
hjic-110	255	15	7.4	7.4	NUM
hjic-110	255	16	phosphate	phosphate	NOUN
hjic-110	255	17	buffer	buffer	NOUN
hjic-110	255	18	solution	solution	NOUN
hjic-110	255	19	.	.	PUNCT
hjic-110	256	1	the	the	DET
hjic-110	256	2	amorphous	amorphous	ADJ
hjic-110	256	3	oxeglitazar	oxeglitazar	NOUN
hjic-110	256	4	dispersed	disperse	VERB
hjic-110	256	5	in	in	ADP
hjic-110	256	6	pvp	pvp	PROPN
hjic-110	256	7	k17	k17	PROPN
hjic-110	256	8	was	be	AUX
hjic-110	256	9	stabilized	stabilize	VERB
hjic-110	256	10	by	by	ADP
hjic-110	256	11	hydrogen	hydrogen	NOUN
hjic-110	256	12	bonding	bonding	NOUN
hjic-110	256	13	and	and	CCONJ
hjic-110	256	14	dissolved	dissolve	VERB
hjic-110	256	15	faster	fast	ADV
hjic-110	256	16	but	but	CCONJ
hjic-110	256	17	contained	contain	VERB
hjic-110	256	18	higher	high	ADJ
hjic-110	256	19	amount	amount	NOUN
hjic-110	256	20	of	of	ADP
hjic-110	256	21	residual	residual	ADJ
hjic-110	256	22	dcm	dcm	NOUN
hjic-110	256	23	than	than	ADP
hjic-110	256	24	poloxamer	poloxamer	NOUN
hjic-110	256	25	407	407	NUM
hjic-110	256	26	formulations	formulation	NOUN
hjic-110	256	27	.	.	PUNCT
hjic-110	257	1	sas	sas	PROPN
hjic-110	257	2	prepared	prepare	VERB
hjic-110	257	3	oxeglitazar	oxeglitazar	NOUN
hjic-110	257	4	/	/	SYM
hjic-110	257	5	poloxamer	poloxamer	NOUN
hjic-110	257	6	407	407	NUM
hjic-110	257	7	solid	solid	ADJ
hjic-110	257	8	dispersion	dispersion	NOUN
hjic-110	257	9	satisfied	satisfy	VERB
hjic-110	257	10	all	all	DET
hjic-110	257	11	requirements	requirement	NOUN
hjic-110	257	12	concerning	concern	VERB
hjic-110	257	13	the	the	DET
hjic-110	257	14	residual	residual	ADJ
hjic-110	257	15	solvent	solvent	NOUN
hjic-110	257	16	content	content	NOUN
hjic-110	257	17	,	,	PUNCT
hjic-110	257	18	polymorphic	polymorphic	ADJ
hjic-110	257	19	purity	purity	NOUN
hjic-110	257	20	and	and	CCONJ
hjic-110	257	21	in	in	ADP
hjic-110	257	22	vitro	vitro	X
hjic-110	257	23	dissolution	dissolution	NOUN
hjic-110	257	24	rate	rate	NOUN
hjic-110	257	25	.	.	PUNCT
hjic-110	258	1	however	however	ADV
hjic-110	258	2	,	,	PUNCT
hjic-110	258	3	one	one	PRON
hjic-110	258	4	must	must	AUX
hjic-110	258	5	keep	keep	VERB
hjic-110	258	6	in	in	ADP
hjic-110	258	7	mind	mind	NOUN
hjic-110	258	8	that	that	SCONJ
hjic-110	258	9	the	the	DET
hjic-110	258	10	results	result	NOUN
hjic-110	258	11	obtained	obtain	VERB
hjic-110	258	12	with	with	ADP
hjic-110	258	13	these	these	DET
hjic-110	258	14	techniques	technique	NOUN
hjic-110	258	15	are	be	AUX
hjic-110	258	16	highly	highly	ADV
hjic-110	258	17	specific	specific	ADJ
hjic-110	258	18	to	to	ADP
hjic-110	258	19	a	a	DET
hjic-110	258	20	particular	particular	ADJ
hjic-110	258	21	formulation	formulation	NOUN
hjic-110	258	22	.	.	PUNCT
hjic-110	259	1	other	other	ADJ
hjic-110	259	2	drug	drug	NOUN
hjic-110	259	3	-	-	PUNCT
hjic-110	259	4	carrier	carrier	NOUN
hjic-110	259	5	systems	system	NOUN
hjic-110	259	6	have	have	VERB
hjic-110	259	7	different	different	ADJ
hjic-110	259	8	characteristic	characteristic	ADJ
hjic-110	259	9	properties	property	NOUN
hjic-110	259	10	;	;	PUNCT
hjic-110	259	11	thus	thus	ADV
hjic-110	259	12	,	,	PUNCT
hjic-110	259	13	it	it	PRON
hjic-110	259	14	’s	’s	AUX
hjic-110	259	15	recommended	recommend	VERB
hjic-110	259	16	to	to	PART
hjic-110	259	17	perform	perform	VERB
hjic-110	259	18	new	new	ADJ
hjic-110	259	19	experiments	experiment	NOUN
hjic-110	259	20	in	in	ADP
hjic-110	259	21	all	all	DET
hjic-110	259	22	cases	case	NOUN
hjic-110	259	23	.	.	PUNCT
hjic-110	260	1	sas	sas	PROPN
hjic-110	260	2	process	process	NOUN
hjic-110	260	3	is	be	AUX
hjic-110	260	4	influenced	influence	VERB
hjic-110	260	5	by	by	ADP
hjic-110	260	6	several	several	ADJ
hjic-110	260	7	operating	operating	NOUN
hjic-110	260	8	parameters	parameter	NOUN
hjic-110	260	9	that	that	PRON
hjic-110	260	10	might	might	AUX
hjic-110	260	11	allow	allow	VERB
hjic-110	260	12	better	well	ADJ
hjic-110	260	13	control	control	NOUN
hjic-110	260	14	over	over	ADP
hjic-110	260	15	the	the	DET
hjic-110	260	16	physical	physical	ADJ
hjic-110	260	17	properties	property	NOUN
hjic-110	260	18	of	of	ADP
hjic-110	260	19	the	the	DET
hjic-110	260	20	prepared	prepared	ADJ
hjic-110	260	21	formulations	formulation	NOUN
hjic-110	260	22	.	.	PUNCT
hjic-110	261	1	acknowledgements	acknowledgement	NOUN
hjic-110	261	2	the	the	DET
hjic-110	261	3	authors	author	NOUN
hjic-110	261	4	kindly	kindly	ADV
hjic-110	261	5	acknowledge	acknowledge	VERB
hjic-110	261	6	the	the	DET
hjic-110	261	7	financial	financial	ADJ
hjic-110	261	8	support	support	NOUN
hjic-110	261	9	from	from	ADP
hjic-110	261	10	merck	merck	PROPN
hjic-110	261	11	santé	santé	PROPN
hjic-110	261	12	,	,	PUNCT
hjic-110	261	13	france	france	PROPN
hjic-110	261	14	;	;	PUNCT
hjic-110	261	15	and	and	CCONJ
hjic-110	261	16	the	the	DET
hjic-110	261	17	fellowship	fellowship	NOUN
hjic-110	261	18	from	from	ADP
hjic-110	261	19	the	the	DET
hjic-110	261	20	french	french	ADJ
hjic-110	261	21	government	government	NOUN
hjic-110	261	22	awarded	award	VERB
hjic-110	261	23	by	by	ADP
hjic-110	261	24	the	the	DET
hjic-110	261	25	cultural	cultural	ADJ
hjic-110	261	26	and	and	CCONJ
hjic-110	261	27	cooperation	cooperation	NOUN
hjic-110	261	28	service	service	NOUN
hjic-110	261	29	of	of	ADP
hjic-110	261	30	the	the	DET
hjic-110	261	31	french	french	ADJ
hjic-110	261	32	embassy	embassy	NOUN
hjic-110	261	33	in	in	ADP
hjic-110	261	34	hungary	hungary	PROPN
hjic-110	261	35	.	.	PUNCT
hjic-110	262	1	viktor	viktor	PROPN
hjic-110	262	2	majerik	majerik	PROPN
hjic-110	262	3	also	also	ADV
hjic-110	262	4	acknowledge	acknowledge	VERB
hjic-110	262	5	the	the	DET
hjic-110	262	6	financial	financial	ADJ
hjic-110	262	7	support	support	NOUN
hjic-110	262	8	from	from	ADP
hjic-110	262	9	the	the	DET
hjic-110	262	10	foundations	foundation	NOUN
hjic-110	262	11	„	„	PUNCT
hjic-110	262	12	industry	industry	NOUN
hjic-110	262	13	for	for	ADP
hjic-110	262	14	engineering	engineer	VERB
hjic-110	262	15	education	education	NOUN
hjic-110	262	16	in	in	ADP
hjic-110	262	17	veszprém	veszprém	NOUN
hjic-110	262	18	”	"	PUNCT
hjic-110	262	19	and	and	CCONJ
hjic-110	262	20	„	„	PUNCT
hjic-110	262	21	peregrinatio	peregrinatio	X
hjic-110	262	22	i	i	PRON
hjic-110	262	23	”	"	PUNCT
hjic-110	262	24	.	.	PUNCT
hjic-110	263	1	references	reference	NOUN
hjic-110	263	2	1	1	NUM
hjic-110	263	3	.	.	PUNCT
hjic-110	263	4	majerik	majerik	PROPN
hjic-110	263	5	v.	v.	PROPN
hjic-110	263	6	,	,	PUNCT
hjic-110	263	7	charbit	charbit	NOUN
hjic-110	263	8	g	g	NOUN
hjic-110	263	9	,	,	PUNCT
hjic-110	263	10	badens	badens	PROPN
hjic-110	263	11	e.	e.	PROPN
hjic-110	263	12	,	,	PUNCT
hjic-110	263	13	horváth	horváth	PROPN
hjic-110	263	14	g.	g.	PROPN
hjic-110	263	15	,	,	PUNCT
hjic-110	263	16	szokonya	szokonya	PROPN
hjic-110	263	17	l.	l.	PROPN
hjic-110	263	18	,	,	PUNCT
hjic-110	263	19	bosc	bosc	PROPN
hjic-110	263	20	n.	n.	PROPN
hjic-110	263	21	,	,	PUNCT
hjic-110	263	22	teillaud	teillaud	PROPN
hjic-110	263	23	e.	e.	PROPN
hjic-110	263	24	:	:	PUNCT
hjic-110	263	25	j.	j.	PROPN
hjic-110	263	26	supercrit	supercrit	PROPN
hjic-110	263	27	.	.	PUNCT
hjic-110	264	1	fluids	fluid	NOUN
hjic-110	264	2	,	,	PUNCT
hjic-110	264	3	in	in	ADP
hjic-110	264	4	press	press	NOUN
hjic-110	264	5	2	2	NUM
hjic-110	264	6	.	.	PUNCT
hjic-110	264	7	fda	fda	PROPN
hjic-110	264	8	,	,	PUNCT
hjic-110	264	9	2002	2002	NUM
hjic-110	264	10	.	.	PUNCT
hjic-110	265	1	draft	draft	NOUN
hjic-110	265	2	–	–	PUNCT
hjic-110	265	3	guidance	guidance	NOUN
hjic-110	265	4	for	for	ADP
hjic-110	265	5	industry	industry	NOUN
hjic-110	265	6	:	:	PUNCT
hjic-110	265	7	bioavailability	bioavailability	NOUN
hjic-110	265	8	and	and	CCONJ
hjic-110	265	9	bioequivalence	bioequivalence	NOUN
hjic-110	265	10	studies	study	NOUN
hjic-110	265	11	for	for	ADP
hjic-110	265	12	orally	orally	ADV
hjic-110	265	13	administered	administer	VERB
hjic-110	265	14	drug	drug	NOUN
hjic-110	265	15	products	product	NOUN
hjic-110	265	16	.	.	PUNCT
hjic-110	266	1	u.s	u.s	PROPN
hjic-110	266	2	.	.	PROPN
hjic-110	266	3	department	department	PROPN
hjic-110	266	4	of	of	ADP
hjic-110	266	5	health	health	PROPN
hjic-110	266	6	and	and	CCONJ
hjic-110	266	7	human	human	ADJ
hjic-110	266	8	services	service	NOUN
hjic-110	266	9	,	,	PUNCT
hjic-110	266	10	food	food	NOUN
hjic-110	266	11	and	and	CCONJ
hjic-110	266	12	drug	drug	NOUN
hjic-110	266	13	49	49	NUM
hjic-110	266	14	administration	administration	NOUN
hjic-110	266	15	,	,	PUNCT
hjic-110	266	16	center	center	NOUN
hjic-110	266	17	for	for	ADP
hjic-110	266	18	drug	drug	NOUN
hjic-110	266	19	evaluation	evaluation	NOUN
hjic-110	266	20	and	and	CCONJ
hjic-110	266	21	research	research	NOUN
hjic-110	266	22	3	3	NUM
hjic-110	266	23	.	.	PUNCT
hjic-110	267	1	lindenberg	lindenberg	PROPN
hjic-110	267	2	m.	m.	PROPN
hjic-110	267	3	,	,	PUNCT
hjic-110	267	4	kopp	kopp	PROPN
hjic-110	267	5	s.	s.	PROPN
hjic-110	267	6	,	,	PUNCT
hjic-110	267	7	dressman	dressman	PROPN
hjic-110	267	8	j.	j.	PROPN
hjic-110	267	9	b.	b.	PROPN
hjic-110	267	10	:	:	PUNCT
hjic-110	267	11	eur	eur	PROPN
hjic-110	267	12	.	.	PUNCT
hjic-110	268	1	j.	j.	PROPN
hjic-110	268	2	pharm	pharm	PROPN
hjic-110	268	3	.	.	PUNCT
hjic-110	269	1	biopharm	biopharm	PROPN
hjic-110	269	2	.	.	PUNCT
hjic-110	269	3	,	,	PUNCT
hjic-110	269	4	2004	2004	NUM
hjic-110	269	5	,	,	PUNCT
hjic-110	269	6	58	58	NUM
hjic-110	269	7	,	,	PUNCT
hjic-110	269	8	265	265	NUM
hjic-110	269	9	-	-	SYM
hjic-110	269	10	278	278	NUM
hjic-110	269	11	4	4	NUM
hjic-110	269	12	.	.	PUNCT
hjic-110	270	1	szente	szente	PROPN
hjic-110	270	2	l.	l.	PROPN
hjic-110	270	3	,	,	PUNCT
hjic-110	270	4	szejtli	szejtli	PROPN
hjic-110	270	5	j.	j.	PROPN
hjic-110	270	6	:	:	PUNCT
hjic-110	270	7	adv	adv	PROPN
hjic-110	270	8	.	.	PUNCT
hjic-110	270	9	drug	drug	PROPN
hjic-110	270	10	delivery	delivery	NOUN
hjic-110	270	11	rev	rev	VERB
hjic-110	270	12	.	.	PROPN
hjic-110	270	13	,	,	PUNCT
hjic-110	270	14	1999	1999	NUM
hjic-110	270	15	,	,	PUNCT
hjic-110	270	16	36	36	NUM
hjic-110	270	17	,	,	PUNCT
hjic-110	270	18	17	17	NUM
hjic-110	270	19	-	-	SYM
hjic-110	270	20	28	28	NUM
hjic-110	270	21	5	5	NUM
hjic-110	270	22	.	.	PUNCT
hjic-110	271	1	world	world	PROPN
hjic-110	271	2	pat	pat	PROPN
hjic-110	271	3	.	.	PROPN
hjic-110	271	4	0232462	0232462	NUM
hjic-110	271	5	6	6	NUM
hjic-110	271	6	.	.	PUNCT
hjic-110	272	1	world	world	PROPN
hjic-110	272	2	pat	pat	PROPN
hjic-110	272	3	.	.	PROPN
hjic-110	272	4	04096284	04096284	NUM
hjic-110	272	5	7	7	X
hjic-110	272	6	.	.	PUNCT
hjic-110	272	7	cassidy	cassidy	PROPN
hjic-110	272	8	o.	o.	PROPN
hjic-110	272	9	e.	e.	PROPN
hjic-110	272	10	,	,	PUNCT
hjic-110	272	11	haskayne	haskayne	PROPN
hjic-110	272	12	l.	l.	PROPN
hjic-110	272	13	,	,	PUNCT
hjic-110	272	14	rowley	rowley	PROPN
hjic-110	272	15	g.	g.	PROPN
hjic-110	272	16	:	:	PUNCT
hjic-110	272	17	eur	eur	PROPN
hjic-110	272	18	.	.	PUNCT
hjic-110	273	1	j.	j.	PROPN
hjic-110	273	2	pharma	pharma	PROPN
hjic-110	273	3	.	.	PUNCT
hjic-110	274	1	sci	sci	PROPN
hjic-110	274	2	.	.	PROPN
hjic-110	274	3	,	,	PUNCT
hjic-110	274	4	1998	1998	NUM
hjic-110	274	5	,	,	PUNCT
hjic-110	274	6	6	6	NUM
hjic-110	274	7	,	,	PUNCT
hjic-110	274	8	s23	s23	NOUN
hjic-110	274	9	8	8	NUM
hjic-110	274	10	.	.	PUNCT
hjic-110	274	11	rasenack	rasenack	NOUN
hjic-110	274	12	n.	n.	PROPN
hjic-110	274	13	,	,	PUNCT
hjic-110	274	14	steckel	steckel	PROPN
hjic-110	274	15	h.	h.	PROPN
hjic-110	274	16	,	,	PUNCT
hjic-110	274	17	müller	müller	PROPN
hjic-110	274	18	b.	b.	PROPN
hjic-110	274	19	w.	w.	PROPN
hjic-110	274	20	:	:	PUNCT
hjic-110	274	21	powder	powder	NOUN
hjic-110	274	22	tech	tech	NOUN
hjic-110	274	23	.	.	PUNCT
hjic-110	274	24	,	,	PUNCT
hjic-110	274	25	2004	2004	NUM
hjic-110	274	26	,	,	PUNCT
hjic-110	274	27	143	143	NUM
hjic-110	274	28	-	-	SYM
hjic-110	274	29	144	144	NUM
hjic-110	274	30	,	,	PUNCT
hjic-110	274	31	291	291	NUM
hjic-110	274	32	-	-	SYM
hjic-110	274	33	296	296	NUM
hjic-110	274	34	9	9	NUM
hjic-110	274	35	.	.	PUNCT
hjic-110	274	36	leuner	leuner	PROPN
hjic-110	274	37	c.	c.	PROPN
hjic-110	274	38	,	,	PUNCT
hjic-110	274	39	dressman	dressman	PROPN
hjic-110	274	40	j.	j.	PROPN
hjic-110	274	41	:	:	PROPN
hjic-110	274	42	eur	eur	PROPN
hjic-110	274	43	.	.	PUNCT
hjic-110	275	1	j.	j.	PROPN
hjic-110	275	2	pharm	pharm	PROPN
hjic-110	275	3	.	.	PUNCT
hjic-110	275	4	,	,	PUNCT
hjic-110	275	5	2000	2000	NUM
hjic-110	275	6	,	,	PUNCT
hjic-110	275	7	50	50	NUM
hjic-110	275	8	,	,	PUNCT
hjic-110	275	9	47	47	NUM
hjic-110	275	10	-	-	SYM
hjic-110	275	11	60	60	NUM
hjic-110	275	12	10	10	NUM
hjic-110	275	13	.	.	PUNCT
hjic-110	276	1	van	van	PROPN
hjic-110	276	2	nijlen	nijlen	ADJ
hjic-110	276	3	t.	t.	PROPN
hjic-110	276	4	,	,	PUNCT
hjic-110	276	5	brennan	brennan	PROPN
hjic-110	276	6	k.	k.	PROPN
hjic-110	276	7	,	,	PUNCT
hjic-110	276	8	van	van	PROPN
hjic-110	276	9	den	den	PROPN
hjic-110	276	10	mooter	mooter	PROPN
hjic-110	276	11	g.	g.	PROPN
hjic-110	276	12	,	,	PUNCT
hjic-110	276	13	blaton	blaton	PROPN
hjic-110	276	14	n.	n.	PROPN
hjic-110	276	15	,	,	PUNCT
hjic-110	276	16	kinget	kinget	PROPN
hjic-110	276	17	r.	r.	PROPN
hjic-110	276	18	,	,	PUNCT
hjic-110	276	19	augustijns	augustijns	NOUN
hjic-110	276	20	p.	p.	NOUN
hjic-110	276	21	:	:	PUNCT
hjic-110	276	22	int	int	NOUN
hjic-110	276	23	.	.	PUNCT
hjic-110	277	1	j.	j.	PROPN
hjic-110	277	2	pharma	pharma	PROPN
hjic-110	277	3	.	.	PROPN
hjic-110	277	4	,	,	PUNCT
hjic-110	277	5	2003	2003	NUM
hjic-110	277	6	,	,	PUNCT
hjic-110	277	7	254	254	NUM
hjic-110	277	8	,	,	PUNCT
hjic-110	277	9	173	173	NUM
hjic-110	277	10	-	-	SYM
hjic-110	277	11	181	181	NUM
hjic-110	277	12	11	11	NUM
hjic-110	277	13	.	.	PUNCT
hjic-110	278	1	sethia	sethia	PROPN
hjic-110	278	2	s.	s.	PROPN
hjic-110	278	3	,	,	PUNCT
hjic-110	278	4	squillante	squillante	PROPN
hjic-110	278	5	e.	e.	PROPN
hjic-110	278	6	:	:	PUNCT
hjic-110	278	7	int	int	PROPN
hjic-110	278	8	.	.	PUNCT
hjic-110	279	1	j.	j.	PROPN
hjic-110	279	2	pharm	pharm	PROPN
hjic-110	279	3	.	.	PROPN
hjic-110	279	4	,	,	PUNCT
hjic-110	279	5	2004	2004	NUM
hjic-110	279	6	,	,	PUNCT
hjic-110	279	7	272	272	NUM
hjic-110	279	8	,	,	PUNCT
hjic-110	279	9	1	1	NUM
hjic-110	279	10	-	-	SYM
hjic-110	279	11	10	10	NUM
hjic-110	279	12	12	12	NUM
hjic-110	279	13	.	.	PUNCT
hjic-110	280	1	sethia	sethia	PROPN
hjic-110	280	2	s.	s.	PROPN
hjic-110	280	3	,	,	PUNCT
hjic-110	280	4	squillante	squillante	PROPN
hjic-110	280	5	e.	e.	PROPN
hjic-110	280	6	:	:	PUNCT
hjic-110	280	7	.	.	PUNCT
hjic-110	281	1	crit	crit	PROPN
hjic-110	281	2	.	.	PUNCT
hjic-110	282	1	rev	rev	PROPN
hjic-110	282	2	.	.	PROPN
hjic-110	283	1	ther	ther	PROPN
hjic-110	283	2	.	.	PUNCT
hjic-110	284	1	drug	drug	NOUN
hjic-110	284	2	carrier	carrier	NOUN
hjic-110	284	3	syst	syst	PROPN
hjic-110	284	4	.	.	PROPN
hjic-110	284	5	,	,	PUNCT
hjic-110	284	6	2003	2003	NUM
hjic-110	284	7	,	,	PUNCT
hjic-110	284	8	20	20	NUM
hjic-110	284	9	,	,	PUNCT
hjic-110	284	10	215	215	NUM
hjic-110	284	11	-	-	SYM
hjic-110	284	12	247	247	NUM
hjic-110	284	13	13	13	NUM
hjic-110	284	14	.	.	PUNCT
hjic-110	285	1	bitz	bitz	PROPN
hjic-110	285	2	c.	c.	PROPN
hjic-110	285	3	,	,	PUNCT
hjic-110	285	4	doelker	doelker	PROPN
hjic-110	285	5	e.	e.	PROPN
hjic-110	285	6	:	:	PUNCT
hjic-110	285	7	int	int	PROPN
hjic-110	285	8	.	.	PUNCT
hjic-110	286	1	j.	j.	PROPN
hjic-110	286	2	pharm	pharm	PROPN
hjic-110	286	3	.	.	PUNCT
hjic-110	286	4	,	,	PUNCT
hjic-110	286	5	1996	1996	NUM
hjic-110	286	6	,	,	PUNCT
hjic-110	286	7	131	131	NUM
hjic-110	286	8	,	,	PUNCT
hjic-110	286	9	171181	171181	NUM
hjic-110	286	10	14	14	NUM
hjic-110	286	11	.	.	PUNCT
hjic-110	287	1	singhal	singhal	PROPN
hjic-110	287	2	d.	d.	PROPN
hjic-110	287	3	,	,	PUNCT
hjic-110	287	4	curatolo	curatolo	PROPN
hjic-110	287	5	w.	w.	PROPN
hjic-110	287	6	:	:	PUNCT
hjic-110	287	7	adv	adv	PROPN
hjic-110	287	8	.	.	PROPN
hjic-110	287	9	drug	drug	PROPN
hjic-110	287	10	del	del	PROPN
hjic-110	287	11	.	.	PROPN
hjic-110	287	12	rev	rev	PROPN
hjic-110	287	13	.	.	PROPN
hjic-110	287	14	,	,	PUNCT
hjic-110	287	15	2004	2004	NUM
hjic-110	287	16	,	,	PUNCT
hjic-110	287	17	56	56	NUM
hjic-110	287	18	,	,	PUNCT
hjic-110	287	19	335	335	NUM
hjic-110	287	20	-	-	SYM
hjic-110	287	21	347	347	NUM
hjic-110	287	22	15	15	NUM
hjic-110	287	23	.	.	PUNCT
hjic-110	288	1	bauer	bauer	PROPN
hjic-110	288	2	j.	j.	PROPN
hjic-110	288	3	,	,	PUNCT
hjic-110	288	4	spanton	spanton	PROPN
hjic-110	288	5	s.	s.	PROPN
hjic-110	288	6	,	,	PUNCT
hjic-110	288	7	henry	henry	PROPN
hjic-110	288	8	r.	r.	PROPN
hjic-110	288	9	,	,	PUNCT
hjic-110	288	10	quick	quick	ADJ
hjic-110	288	11	j.	j.	PROPN
hjic-110	288	12	,	,	PUNCT
hjic-110	288	13	dziki	dziki	PROPN
hjic-110	288	14	w.	w.	PROPN
hjic-110	288	15	,	,	PUNCT
hjic-110	288	16	porter	porter	PROPN
hjic-110	288	17	w.	w.	PROPN
hjic-110	288	18	,	,	PUNCT
hjic-110	288	19	morris	morris	PROPN
hjic-110	288	20	,	,	PUNCT
hjic-110	288	21	j.	j.	PROPN
hjic-110	288	22	:	:	PUNCT
hjic-110	288	23	pharm	pharm	PROPN
hjic-110	288	24	.	.	PUNCT
hjic-110	289	1	res	re	NOUN
hjic-110	289	2	.	.	PROPN
hjic-110	289	3	,	,	PUNCT
hjic-110	289	4	2001	2001	NUM
hjic-110	289	5	,	,	PUNCT
hjic-110	289	6	18	18	NUM
hjic-110	289	7	,	,	PUNCT
hjic-110	289	8	859	859	NUM
hjic-110	289	9	-	-	SYM
hjic-110	289	10	866	866	NUM
hjic-110	289	11	16	16	NUM
hjic-110	289	12	.	.	PUNCT
hjic-110	290	1	world	world	PROPN
hjic-110	290	2	pat	pat	PROPN
hjic-110	290	3	.	.	PROPN
hjic-110	290	4	0115664	0115664	NUM
hjic-110	290	5	17	17	NUM
hjic-110	290	6	.	.	PUNCT
hjic-110	291	1	york	york	PROPN
hjic-110	291	2	p.	p.	PROPN
hjic-110	291	3	:	:	PUNCT
hjic-110	292	1	pharma	pharma	PROPN
hjic-110	292	2	.	.	PUNCT
hjic-110	293	1	sci	sci	PROPN
hjic-110	293	2	.	.	PUNCT
hjic-110	293	3	tech	tech	PROPN
hjic-110	293	4	.	.	PUNCT
hjic-110	294	1	today	today	NOUN
hjic-110	294	2	,	,	PUNCT
hjic-110	294	3	1999	1999	NUM
hjic-110	294	4	,	,	PUNCT
hjic-110	294	5	11	11	NUM
hjic-110	294	6	,	,	PUNCT
hjic-110	294	7	430	430	NUM
hjic-110	294	8	-	-	SYM
hjic-110	294	9	440	440	NUM
hjic-110	294	10	18	18	NUM
hjic-110	294	11	.	.	PUNCT
hjic-110	295	1	jung	jung	PROPN
hjic-110	295	2	j.	j.	PROPN
hjic-110	295	3	,	,	PUNCT
hjic-110	295	4	perrut	perrut	NOUN
hjic-110	295	5	m.	m.	NOUN
hjic-110	295	6	:	:	PUNCT
hjic-110	295	7	j.	j.	PROPN
hjic-110	295	8	supercrit	supercrit	PROPN
hjic-110	295	9	.	.	PUNCT
hjic-110	295	10	fluids	fluid	NOUN
hjic-110	295	11	,	,	PUNCT
hjic-110	295	12	2001	2001	NUM
hjic-110	295	13	,	,	PUNCT
hjic-110	295	14	20	20	NUM
hjic-110	295	15	,	,	PUNCT
hjic-110	295	16	179	179	NUM
hjic-110	295	17	-	-	SYM
hjic-110	295	18	219	219	NUM
hjic-110	295	19	19	19	NUM
hjic-110	295	20	.	.	PUNCT
hjic-110	295	21	charbit	charbit	PROPN
hjic-110	295	22	g.	g.	PROPN
hjic-110	295	23	,	,	PUNCT
hjic-110	295	24	badens	badens	PROPN
hjic-110	295	25	e.	e.	PROPN
hjic-110	295	26	,	,	PUNCT
hjic-110	295	27	boutin	boutin	PROPN
hjic-110	295	28	o.	o.	PROPN
hjic-110	295	29	:	:	PUNCT
hjic-110	295	30	methods	method	NOUN
hjic-110	295	31	of	of	ADP
hjic-110	295	32	particle	particle	NOUN
hjic-110	295	33	production	production	NOUN
hjic-110	295	34	.	.	PUNCT
hjic-110	296	1	in	in	ADP
hjic-110	296	2	:	:	PUNCT
hjic-110	296	3	york	york	PROPN
hjic-110	296	4	p.	p.	PROPN
hjic-110	296	5	,	,	PUNCT
hjic-110	296	6	kompella	kompella	PROPN
hjic-110	296	7	u.	u.	PROPN
hjic-110	296	8	b.	b.	PROPN
hjic-110	296	9	,	,	PUNCT
hjic-110	296	10	shekunov	shekunov	PROPN
hjic-110	296	11	b.	b.	PROPN
hjic-110	296	12	y.	y.	PROPN
hjic-110	296	13	:	:	PUNCT
hjic-110	296	14	supercritical	supercritical	ADJ
hjic-110	296	15	fluid	fluid	ADJ
hjic-110	296	16	technology	technology	NOUN
hjic-110	296	17	for	for	ADP
hjic-110	296	18	drug	drug	NOUN
hjic-110	296	19	product	product	NOUN
hjic-110	296	20	development	development	NOUN
hjic-110	296	21	,	,	PUNCT
hjic-110	296	22	drugs	drug	NOUN
hjic-110	296	23	and	and	CCONJ
hjic-110	296	24	pharmaceutical	pharmaceutical	NOUN
hjic-110	296	25	sciences	sciences	PROPN
hjic-110	296	26	vol	vol	NOUN
hjic-110	296	27	.	.	PROPN
hjic-110	296	28	138	138	NUM
hjic-110	296	29	,	,	PUNCT
hjic-110	296	30	marcel	marcel	PROPN
hjic-110	296	31	dekker	dekker	PROPN
hjic-110	296	32	inc	inc	PROPN
hjic-110	296	33	.	.	PROPN
hjic-110	296	34	,	,	PUNCT
hjic-110	296	35	new	new	PROPN
hjic-110	296	36	york	york	PROPN
hjic-110	296	37	,	,	PUNCT
hjic-110	296	38	pp	pp	PROPN
hjic-110	296	39	.	.	PUNCT
hjic-110	296	40	159	159	NUM
hjic-110	296	41	-	-	SYM
hjic-110	296	42	212	212	NUM
hjic-110	296	43	,	,	PUNCT
hjic-110	296	44	2004	2004	NUM
hjic-110	296	45	20	20	NUM
hjic-110	296	46	.	.	PUNCT
hjic-110	296	47	majerik	majerik	PROPN
hjic-110	296	48	v.	v.	PROPN
hjic-110	296	49	,	,	PUNCT
hjic-110	296	50	horváth	horváth	PROPN
hjic-110	296	51	g.	g.	PROPN
hjic-110	296	52	,	,	PUNCT
hjic-110	296	53	charbit	charbit	NOUN
hjic-110	296	54	g.	g.	PROPN
hjic-110	296	55	,	,	PUNCT
hjic-110	296	56	badens	badens	PROPN
hjic-110	296	57	e.	e.	PROPN
hjic-110	296	58	,	,	PUNCT
hjic-110	296	59	szokonya	szokonya	PROPN
hjic-110	296	60	l.	l.	PROPN
hjic-110	296	61	,	,	PUNCT
hjic-110	296	62	bosc	bosc	PROPN
hjic-110	296	63	n.	n.	PROPN
hjic-110	296	64	,	,	PUNCT
hjic-110	296	65	teillaud	teillaud	PROPN
hjic-110	296	66	e.	e.	PROPN
hjic-110	296	67	:	:	PUNCT
hjic-110	296	68	hun	hun	PROPN
hjic-110	296	69	.	.	PUNCT
hjic-110	297	1	j.	j.	PROPN
hjic-110	297	2	ind	ind	PROPN
hjic-110	297	3	.	.	PUNCT
hjic-110	298	1	chem	chem	PROPN
hjic-110	298	2	.	.	PUNCT
hjic-110	298	3	,	,	PUNCT
hjic-110	298	4	2004	2004	NUM
hjic-110	298	5	,	,	PUNCT
hjic-110	298	6	32	32	NUM
hjic-110	298	7	,	,	PUNCT
hjic-110	298	8	41	41	NUM
hjic-110	298	9	-	-	SYM
hjic-110	298	10	56	56	NUM
hjic-110	298	11	21	21	NUM
hjic-110	298	12	.	.	PUNCT
hjic-110	299	1	pasquali	pasquali	PROPN
hjic-110	299	2	i.	i.	PROPN
hjic-110	299	3	,	,	PUNCT
hjic-110	299	4	bettini	bettini	PROPN
hjic-110	299	5	r.	r.	PROPN
hjic-110	299	6	,	,	PUNCT
hjic-110	299	7	giordano	giordano	PROPN
hjic-110	299	8	f.	f.	PROPN
hjic-110	299	9	:	:	PUNCT
hjic-110	299	10	eur	eur	PROPN
hjic-110	299	11	.	.	PUNCT
hjic-110	300	1	j.	j.	PROPN
hjic-110	300	2	pharm	pharm	PROPN
hjic-110	300	3	.	.	PUNCT
hjic-110	301	1	sci	sci	PROPN
hjic-110	301	2	.	.	PROPN
hjic-110	301	3	,	,	PUNCT
hjic-110	301	4	2006	2006	NUM
hjic-110	301	5	,	,	PUNCT
hjic-110	301	6	27	27	NUM
hjic-110	301	7	,	,	PUNCT
hjic-110	301	8	299	299	NUM
hjic-110	301	9	-	-	SYM
hjic-110	301	10	310	310	NUM
hjic-110	301	11	22	22	NUM
hjic-110	301	12	.	.	PUNCT
hjic-110	302	1	ruchatz	ruchatz	PROPN
hjic-110	302	2	f.	f.	PROPN
hjic-110	302	3	,	,	PUNCT
hjic-110	302	4	kleinebudde	kleinebudde	PROPN
hjic-110	302	5	p.	p.	PROPN
hjic-110	302	6	,	,	PUNCT
hjic-110	303	1	müller	müller	PROPN
hjic-110	303	2	b.	b.	PROPN
hjic-110	303	3	w.	w.	PROPN
hjic-110	303	4	:	:	PUNCT
hjic-110	303	5	int	int	PROPN
hjic-110	303	6	.	.	PUNCT
hjic-110	304	1	j.	j.	PROPN
hjic-110	304	2	pharm	pharm	PROPN
hjic-110	304	3	.	.	PUNCT
hjic-110	305	1	sci	sci	PROPN
hjic-110	305	2	.	.	PROPN
hjic-110	305	3	,	,	PUNCT
hjic-110	305	4	1997	1997	NUM
hjic-110	305	5	,	,	PUNCT
hjic-110	305	6	86	86	NUM
hjic-110	305	7	,	,	PUNCT
hjic-110	305	8	101	101	NUM
hjic-110	305	9	-	-	SYM
hjic-110	305	10	105	105	NUM
hjic-110	305	11	23	23	NUM
hjic-110	305	12	.	.	PUNCT
hjic-110	306	1	beach	beach	PROPN
hjic-110	306	2	s.	s.	PROPN
hjic-110	306	3	,	,	PUNCT
hjic-110	306	4	lathan	lathan	PROPN
hjic-110	306	5	d.	d.	PROPN
hjic-110	306	6	,	,	PUNCT
hjic-110	306	7	sidgwick	sidgwick	PROPN
hjic-110	306	8	c.	c.	PROPN
hjic-110	306	9	,	,	PUNCT
hjic-110	306	10	hanna	hanna	PROPN
hjic-110	306	11	m.	m.	PROPN
hjic-110	306	12	,	,	PUNCT
hjic-110	306	13	york	york	PROPN
hjic-110	306	14	p.	p.	PROPN
hjic-110	306	15	:	:	PUNCT
hjic-110	306	16	org	org	PROPN
hjic-110	306	17	.	.	PUNCT
hjic-110	306	18	proc	proc	PROPN
hjic-110	306	19	.	.	PUNCT
hjic-110	307	1	res	re	NOUN
hjic-110	307	2	.	.	PUNCT
hjic-110	308	1	dev	dev	PROPN
hjic-110	308	2	.	.	PROPN
hjic-110	308	3	,	,	PUNCT
hjic-110	308	4	1999	1999	NUM
hjic-110	308	5	,	,	PUNCT
hjic-110	308	6	3	3	NUM
hjic-110	308	7	,	,	PUNCT
hjic-110	308	8	370	370	NUM
hjic-110	308	9	-	-	SYM
hjic-110	308	10	376	376	NUM
hjic-110	308	11	24	24	NUM
hjic-110	308	12	.	.	PUNCT
hjic-110	309	1	fargeot	fargeot	PROPN
hjic-110	309	2	c.	c.	PROPN
hjic-110	309	3	,	,	PUNCT
hjic-110	309	4	badens	badens	PROPN
hjic-110	309	5	e.	e.	PROPN
hjic-110	309	6	,	,	PUNCT
hjic-110	309	7	charbit	charbit	PROPN
hjic-110	309	8	g.	g.	PROPN
hjic-110	309	9	,	,	PUNCT
hjic-110	309	10	bosc	bosc	PROPN
hjic-110	309	11	n.	n.	PROPN
hjic-110	309	12	,	,	PUNCT
hjic-110	309	13	teillaud	teillaud	PROPN
hjic-110	309	14	e.	e.	PROPN
hjic-110	309	15	,	,	PUNCT
hjic-110	309	16	veesler	veesler	PROPN
hjic-110	309	17	s.	s.	PROPN
hjic-110	309	18	:	:	PUNCT
hjic-110	309	19	2003	2003	NUM
hjic-110	309	20	.	.	PUNCT
hjic-110	310	1	cristallisation	cristallisation	NOUN
hjic-110	310	2	d'un	d'un	PROPN
hjic-110	310	3	prinicipe	prinicipe	PROPN
hjic-110	310	4	actif	actif	PROPN
hjic-110	310	5	:	:	PUNCT
hjic-110	310	6	comparaison	comparaison	PROPN
hjic-110	310	7	des	des	PROPN
hjic-110	310	8	méthodes	méthodes	PROPN
hjic-110	310	9	par	par	PROPN
hjic-110	310	10	voie	voie	PROPN
hjic-110	310	11	liquide	liquide	X
hjic-110	310	12	et	et	PROPN
hjic-110	310	13	supercritique	supercritique	NOUN
hjic-110	310	14	.	.	PUNCT
hjic-110	311	1	the	the	DET
hjic-110	311	2	cristal2	cristal2	NOUN
hjic-110	311	3	,	,	PUNCT
hjic-110	311	4	toulouse	toulouse	NOUN
hjic-110	311	5	,	,	PUNCT
hjic-110	311	6	2003	2003	NUM
hjic-110	311	7	25	25	NUM
hjic-110	311	8	.	.	PUNCT
hjic-110	312	1	badens	badens	PROPN
hjic-110	312	2	e.	e.	PROPN
hjic-110	312	3	,	,	PUNCT
hjic-110	312	4	fargeot	fargeot	PROPN
hjic-110	312	5	c.	c.	PROPN
hjic-110	312	6	,	,	PUNCT
hjic-110	312	7	bosc	bosc	PROPN
hjic-110	312	8	n.	n.	PROPN
hjic-110	312	9	,	,	PUNCT
hjic-110	312	10	veesler	veesler	NOUN
hjic-110	312	11	s.	s.	PROPN
hjic-110	312	12	,	,	PUNCT
hjic-110	312	13	teillaud	teillaud	PROPN
hjic-110	312	14	e.	e.	PROPN
hjic-110	312	15	,	,	PUNCT
hjic-110	312	16	charbit	charbit	NOUN
hjic-110	312	17	g.	g.	NOUN
hjic-110	312	18	:	:	PUNCT
hjic-110	312	19	polymorph	polymorph	NOUN
hjic-110	312	20	control	control	NOUN
hjic-110	312	21	of	of	ADP
hjic-110	312	22	drug	drug	NOUN
hjic-110	312	23	in	in	ADP
hjic-110	312	24	supercritical	supercritical	ADJ
hjic-110	312	25	co2	co2	NOUN
hjic-110	312	26	.	.	PUNCT
hjic-110	313	1	european	european	ADJ
hjic-110	313	2	conference	conference	PROPN
hjic-110	313	3	on	on	ADP
hjic-110	313	4	drug	drug	NOUN
hjic-110	313	5	delivery	delivery	NOUN
hjic-110	313	6	and	and	CCONJ
hjic-110	313	7	pharmaceutical	pharmaceutical	NOUN
hjic-110	313	8	technology	technology	NOUN
hjic-110	313	9	,	,	PUNCT
hjic-110	313	10	sevilla	sevilla	NOUN
hjic-110	313	11	,	,	PUNCT
hjic-110	313	12	2004	2004	NUM
hjic-110	313	13	26	26	NUM
hjic-110	313	14	.	.	PUNCT
hjic-110	314	1	badens	badens	PROPN
hjic-110	314	2	e.	e.	PROPN
hjic-110	314	3	,	,	PUNCT
hjic-110	314	4	teillaud	teillaud	PROPN
hjic-110	314	5	e.	e.	PROPN
hjic-110	314	6	,	,	PUNCT
hjic-110	314	7	charbit	charbit	NOUN
hjic-110	314	8	g.	g.	PROPN
hjic-110	314	9	,	,	PUNCT
hjic-110	314	10	horváth	horváth	PROPN
hjic-110	314	11	g.	g.	PROPN
hjic-110	314	12	,	,	PUNCT
hjic-110	314	13	szokonya	szokonya	PROPN
hjic-110	314	14	l.	l.	PROPN
hjic-110	314	15	,	,	PUNCT
hjic-110	314	16	bosc	bosc	PROPN
hjic-110	314	17	n.	n.	PROPN
hjic-110	314	18	,	,	PUNCT
hjic-110	314	19	majerik	majerik	PROPN
hjic-110	314	20	v.	v.	NOUN
hjic-110	314	21	:	:	PUNCT
hjic-110	314	22	solubility	solubility	NOUN
hjic-110	314	23	enhancement	enhancement	NOUN
hjic-110	314	24	of	of	ADP
hjic-110	314	25	a	a	DET
hjic-110	314	26	pharmaceutical	pharmaceutical	ADJ
hjic-110	314	27	ingredient	ingredient	NOUN
hjic-110	314	28	using	use	VERB
hjic-110	314	29	supercritical	supercritical	ADJ
hjic-110	314	30	antisolvent	antisolvent	NOUN
hjic-110	314	31	and	and	CCONJ
hjic-110	314	32	spray	spray	NOUN
hjic-110	314	33	-	-	PUNCT
hjic-110	314	34	freezing	freeze	VERB
hjic-110	314	35	techniques	technique	NOUN
hjic-110	314	36	.	.	PUNCT
hjic-110	315	1	7th	7th	ADJ
hjic-110	315	2	international	international	ADJ
hjic-110	315	3	symposium	symposium	NOUN
hjic-110	315	4	on	on	ADP
hjic-110	315	5	supercritical	supercritical	ADJ
hjic-110	315	6	fluids	fluid	NOUN
hjic-110	315	7	,	,	PUNCT
hjic-110	315	8	orlando	orlando	PROPN
hjic-110	315	9	,	,	PUNCT
hjic-110	315	10	2005	2005	NUM
hjic-110	315	11	27	27	NUM
hjic-110	315	12	.	.	PUNCT
hjic-110	316	1	jung	jung	PROPN
hjic-110	316	2	j.	j.	PROPN
hjic-110	316	3	,	,	PUNCT
hjic-110	316	4	clavier	clavier	PROPN
hjic-110	316	5	j.	j.	PROPN
hjic-110	316	6	y.	y.	PROPN
hjic-110	316	7	,	,	PUNCT
hjic-110	316	8	perrut	perrut	NOUN
hjic-110	316	9	m.	m.	NOUN
hjic-110	316	10	:	:	PUNCT
hjic-110	316	11	gram	gram	NOUN
hjic-110	316	12	to	to	ADP
hjic-110	316	13	kilogram	kilogram	PROPN
hjic-110	316	14	scale	scale	PROPN
hjic-110	316	15	-	-	PUNCT
hjic-110	316	16	up	up	NOUN
hjic-110	316	17	of	of	ADP
hjic-110	316	18	supercritical	supercritical	ADJ
hjic-110	316	19	anti	anti	ADJ
hjic-110	316	20	-	-	ADJ
hjic-110	316	21	solvent	solvent	ADJ
hjic-110	316	22	process	process	NOUN
hjic-110	316	23	.	.	PUNCT
hjic-110	317	1	6th	6th	ADJ
hjic-110	317	2	international	international	ADJ
hjic-110	317	3	symposium	symposium	NOUN
hjic-110	317	4	on	on	ADP
hjic-110	317	5	supercritical	supercritical	ADJ
hjic-110	317	6	fluids	fluid	NOUN
hjic-110	317	7	,	,	PUNCT
hjic-110	317	8	versailles	versaille	NOUN
hjic-110	317	9	,	,	PUNCT
hjic-110	317	10	2003	2003	NUM
hjic-110	317	11	28	28	NUM
hjic-110	317	12	.	.	PUNCT
hjic-110	318	1	perrut	perrut	PROPN
hjic-110	318	2	m.	m.	NOUN
hjic-110	318	3	,	,	PUNCT
hjic-110	318	4	jung	jung	PROPN
hjic-110	318	5	j.	j.	PROPN
hjic-110	318	6	,	,	PUNCT
hjic-110	318	7	leboeuf	leboeuf	PROPN
hjic-110	318	8	f.	f.	PROPN
hjic-110	318	9	:	:	PUNCT
hjic-110	318	10	int	int	PROPN
hjic-110	318	11	.	.	PUNCT
hjic-110	319	1	j.	j.	PROPN
hjic-110	319	2	pharm	pharm	PROPN
hjic-110	319	3	.	.	PUNCT
hjic-110	319	4	,	,	PUNCT
hjic-110	319	5	2005	2005	NUM
hjic-110	319	6	,	,	PUNCT
hjic-110	319	7	288	288	NUM
hjic-110	319	8	,	,	PUNCT
hjic-110	319	9	11	11	NUM
hjic-110	319	10	-	-	SYM
hjic-110	319	11	16	16	NUM
hjic-110	319	12	29	29	NUM
hjic-110	319	13	.	.	PUNCT
hjic-110	320	1	u.s	u.s	PROPN
hjic-110	320	2	.	.	PROPN
hjic-110	320	3	pat	pat	PROPN
hjic-110	320	4	.	.	PROPN
hjic-110	321	1	5,360,478	5,360,478	NUM
hjic-110	321	2	30	30	NUM
hjic-110	321	3	.	.	PUNCT
hjic-110	321	4	moneghini	moneghini	NOUN
hjic-110	321	5	m.	m.	NOUN
hjic-110	321	6	,	,	PUNCT
hjic-110	321	7	kikic	kikic	PROPN
hjic-110	321	8	i.	i.	PROPN
hjic-110	321	9	,	,	PUNCT
hjic-110	321	10	voinovich	voinovich	PROPN
hjic-110	321	11	d.	d.	PROPN
hjic-110	321	12	,	,	PUNCT
hjic-110	321	13	perissutti	perissutti	PROPN
hjic-110	321	14	b.	b.	PROPN
hjic-110	321	15	,	,	PUNCT
hjic-110	321	16	filipovic	filipovic	PROPN
hjic-110	321	17	-	-	PUNCT
hjic-110	321	18	grcic	grcic	PROPN
hjic-110	321	19	j.	j.	PROPN
hjic-110	321	20	:	:	PUNCT
hjic-110	321	21	int	int	PROPN
hjic-110	321	22	.	.	PUNCT
hjic-110	322	1	j.	j.	PROPN
hjic-110	322	2	pharm	pharm	PROPN
hjic-110	322	3	.	.	PROPN
hjic-110	322	4	,	,	PUNCT
hjic-110	322	5	2001	2001	NUM
hjic-110	322	6	,	,	PUNCT
hjic-110	322	7	222	222	NUM
hjic-110	322	8	,	,	PUNCT
hjic-110	322	9	129	129	NUM
hjic-110	322	10	-	-	SYM
hjic-110	322	11	138	138	NUM
hjic-110	322	12	31	31	NUM
hjic-110	322	13	.	.	PUNCT
hjic-110	323	1	corrigan	corrigan	PROPN
hjic-110	323	2	o.	o.	PROPN
hjic-110	323	3	i.	i.	PROPN
hjic-110	323	4	,	,	PUNCT
hjic-110	323	5	crean	crean	PROPN
hjic-110	323	6	a.	a.	PROPN
hjic-110	323	7	m.	m.	NOUN
hjic-110	323	8	:	:	PUNCT
hjic-110	323	9	int	int	NOUN
hjic-110	323	10	.	.	PUNCT
hjic-110	324	1	j.	j.	PROPN
hjic-110	324	2	pharm	pharm	PROPN
hjic-110	324	3	.	.	PROPN
hjic-110	324	4	,	,	PUNCT
hjic-110	324	5	2002	2002	NUM
hjic-110	324	6	,	,	PUNCT
hjic-110	324	7	245	245	NUM
hjic-110	324	8	,	,	PUNCT
hjic-110	324	9	75	75	NUM
hjic-110	324	10	-	-	SYM
hjic-110	324	11	82	82	NUM
hjic-110	324	12	32	32	NUM
hjic-110	324	13	.	.	PUNCT
hjic-110	325	1	falk	falk	PROPN
hjic-110	325	2	r.	r.	PROPN
hjic-110	325	3	f.	f.	PROPN
hjic-110	325	4	,	,	PUNCT
hjic-110	325	5	randolph	randolph	PROPN
hjic-110	325	6	t.	t.	PROPN
hjic-110	325	7	w.	w.	PROPN
hjic-110	325	8	,	,	PUNCT
hjic-110	325	9	meyer	meyer	PROPN
hjic-110	325	10	j.	j.	PROPN
hjic-110	325	11	d.	d.	PROPN
hjic-110	325	12	,	,	PUNCT
hjic-110	325	13	kelly	kelly	PROPN
hjic-110	325	14	r.	r.	PROPN
hjic-110	325	15	m.	m.	PROPN
hjic-110	325	16	,	,	PUNCT
hjic-110	325	17	manning	man	VERB
hjic-110	325	18	m.	m.	NOUN
hjic-110	325	19	c.	c.	PROPN
hjic-110	325	20	:	:	PUNCT
hjic-110	325	21	j.	j.	PROPN
hjic-110	325	22	cont	cont	PROPN
hjic-110	325	23	.	.	PUNCT
hjic-110	326	1	rel	rel	PROPN
hjic-110	326	2	.	.	PROPN
hjic-110	326	3	,	,	PUNCT
hjic-110	326	4	1997	1997	NUM
hjic-110	326	5	,	,	PUNCT
hjic-110	326	6	44	44	NUM
hjic-110	326	7	,	,	PUNCT
hjic-110	326	8	77	77	NUM
hjic-110	326	9	-	-	SYM
hjic-110	326	10	85	85	NUM
hjic-110	326	11	33	33	NUM
hjic-110	326	12	.	.	PUNCT
hjic-110	327	1	reverchon	reverchon	PROPN
hjic-110	327	2	e.	e.	PROPN
hjic-110	327	3	,	,	PUNCT
hjic-110	327	4	1999	1999	NUM
hjic-110	327	5	.	.	PUNCT
hjic-110	328	1	supercritical	supercritical	ADJ
hjic-110	328	2	antisolvent	antisolvent	PROPN
hjic-110	328	3	precipitation	precipitation	NOUN
hjic-110	328	4	of	of	ADP
hjic-110	328	5	microand	microand	NOUN
hjic-110	328	6	nano	nano	NOUN
hjic-110	328	7	-	-	PUNCT
hjic-110	328	8	particles	particle	NOUN
hjic-110	328	9	.	.	PUNCT
hjic-110	329	1	j.	j.	PROPN
hjic-110	329	2	supercrit	supercrit	PROPN
hjic-110	329	3	.	.	PUNCT
hjic-110	330	1	fluids	fluid	NOUN
hjic-110	330	2	,	,	PUNCT
hjic-110	330	3	15	15	NUM
hjic-110	330	4	,	,	PUNCT
hjic-110	330	5	1	1	NUM
hjic-110	330	6	-	-	SYM
hjic-110	330	7	21	21	NUM
hjic-110	330	8	.	.	PUNCT
hjic-110	331	1	34	34	NUM
hjic-110	331	2	.	.	PUNCT
hjic-110	332	1	reverchon	reverchon	PROPN
hjic-110	332	2	e.	e.	PROPN
hjic-110	332	3	,	,	PUNCT
hjic-110	332	4	della	della	PROPN
hjic-110	332	5	porta	porta	PROPN
hjic-110	332	6	g.	g.	PROPN
hjic-110	332	7	,	,	PUNCT
hjic-110	332	8	de	de	PROPN
hjic-110	332	9	rosa	rosa	PROPN
hjic-110	332	10	i.	i.	PROPN
hjic-110	332	11	,	,	PUNCT
hjic-110	332	12	subra	subra	PROPN
hjic-110	332	13	p.	p.	PROPN
hjic-110	332	14	,	,	PUNCT
hjic-110	332	15	letourneur	letourneur	PROPN
hjic-110	332	16	d.	d.	PROPN
hjic-110	332	17	:	:	PUNCT
hjic-110	332	18	j.	j.	PROPN
hjic-110	332	19	supercrit	supercrit	PROPN
hjic-110	332	20	.	.	PUNCT
hjic-110	332	21	fluids	fluid	NOUN
hjic-110	332	22	,	,	PUNCT
hjic-110	332	23	2000	2000	NUM
hjic-110	332	24	,	,	PUNCT
hjic-110	332	25	18	18	NUM
hjic-110	332	26	,	,	PUNCT
hjic-110	332	27	239	239	NUM
hjic-110	332	28	-	-	SYM
hjic-110	332	29	245	245	NUM
hjic-110	332	30	35	35	NUM
hjic-110	332	31	.	.	PUNCT
hjic-110	333	1	taki	taki	PROPN
hjic-110	333	2	s.	s.	PROPN
hjic-110	333	3	,	,	PUNCT
hjic-110	333	4	badens	badens	PROPN
hjic-110	333	5	e.	e.	PROPN
hjic-110	333	6	,	,	PUNCT
hjic-110	333	7	charbit	charbit	PROPN
hjic-110	333	8	g.	g.	PROPN
hjic-110	333	9	:	:	PUNCT
hjic-110	333	10	j.	j.	PROPN
hjic-110	333	11	supercrit	supercrit	PROPN
hjic-110	333	12	.	.	PUNCT
hjic-110	333	13	fluids	fluid	NOUN
hjic-110	333	14	,	,	PUNCT
hjic-110	333	15	2001	2001	NUM
hjic-110	333	16	,	,	PUNCT
hjic-110	333	17	21	21	NUM
hjic-110	333	18	,	,	PUNCT
hjic-110	333	19	61	61	NUM
hjic-110	333	20	-	-	SYM
hjic-110	333	21	70	70	NUM
hjic-110	333	22	36	36	NUM
hjic-110	333	23	.	.	PUNCT
hjic-110	333	24	won	win	VERB
hjic-110	333	25	d.-h	d.-h	PROPN
hjic-110	333	26	.	.	PUNCT
hjic-110	333	27	,	,	PUNCT
hjic-110	333	28	kim	kim	PROPN
hjic-110	333	29	m.-s	m.-s	PROPN
hjic-110	333	30	.	.	PUNCT
hjic-110	333	31	,	,	PUNCT
hjic-110	333	32	lee	lee	PROPN
hjic-110	333	33	s.	s.	PROPN
hjic-110	333	34	,	,	PUNCT
hjic-110	333	35	park	park	NOUN
hjic-110	333	36	j.-s	j.-	NOUN
hjic-110	333	37	.	.	PUNCT
hjic-110	333	38	,	,	PUNCT
hjic-110	333	39	hwang	hwang	PROPN
hjic-110	333	40	s.-j	s.-j	PROPN
hjic-110	333	41	.	.	PUNCT
hjic-110	333	42	:	:	PUNCT
hjic-110	334	1	int	int	NOUN
hjic-110	334	2	.	.	PUNCT
hjic-110	335	1	j.	j.	PROPN
hjic-110	335	2	pharm	pharm	PROPN
hjic-110	335	3	.	.	PUNCT
hjic-110	335	4	,	,	PUNCT
hjic-110	335	5	2005	2005	NUM
hjic-110	335	6	,	,	PUNCT
hjic-110	335	7	301	301	NUM
hjic-110	335	8	,	,	PUNCT
hjic-110	335	9	199	199	NUM
hjic-110	335	10	-	-	SYM
hjic-110	335	11	208	208	NUM
hjic-110	335	12	37	37	NUM
hjic-110	335	13	.	.	PUNCT
hjic-110	336	1	world	world	PROPN
hjic-110	336	2	pat	pat	PROPN
hjic-110	336	3	.	.	PROPN
hjic-110	337	1	9,501,221	9,501,221	NUM
hjic-110	337	2	38	38	NUM
hjic-110	337	3	.	.	PUNCT
hjic-110	338	1	juppo	juppo	PROPN
hjic-110	338	2	a.	a.	PROPN
hjic-110	338	3	m.	m.	PROPN
hjic-110	338	4	,	,	PUNCT
hjic-110	338	5	boissier	boissier	PROPN
hjic-110	338	6	c.	c.	PROPN
hjic-110	338	7	,	,	PUNCT
hjic-110	338	8	khoo	khoo	PROPN
hjic-110	338	9	c.	c.	PROPN
hjic-110	338	10	:	:	PUNCT
hjic-110	338	11	int	int	PROPN
hjic-110	338	12	.	.	PUNCT
hjic-110	339	1	j.	j.	PROPN
hjic-110	339	2	pharm	pharm	PROPN
hjic-110	339	3	.	.	PROPN
hjic-110	339	4	,	,	PUNCT
hjic-110	339	5	2003	2003	NUM
hjic-110	339	6	,	,	PUNCT
hjic-110	339	7	250	250	NUM
hjic-110	339	8	,	,	PUNCT
hjic-110	339	9	385	385	NUM
hjic-110	339	10	-	-	SYM
hjic-110	339	11	401	401	NUM
hjic-110	339	12	39	39	NUM
hjic-110	339	13	.	.	PUNCT
hjic-110	340	1	kerc	kerc	PROPN
hjic-110	340	2	j.	j.	PROPN
hjic-110	340	3	,	,	PUNCT
hjic-110	340	4	srcic	srcic	PROPN
hjic-110	340	5	s.	s.	PROPN
hjic-110	340	6	,	,	PUNCT
hjic-110	340	7	knez	knez	PROPN
hjic-110	340	8	z.	z.	PROPN
hjic-110	340	9	,	,	PUNCT
hjic-110	340	10	sencar	sencar	NOUN
hjic-110	340	11	-	-	PUNCT
hjic-110	340	12	bozic	bozic	NOUN
hjic-110	340	13	p.	p.	NOUN
hjic-110	340	14	:	:	PUNCT
hjic-110	341	1	int	int	NOUN
hjic-110	341	2	.	.	PUNCT
hjic-110	342	1	j.	j.	PROPN
hjic-110	342	2	pharm	pharm	PROPN
hjic-110	342	3	.	.	PUNCT
hjic-110	342	4	,	,	PUNCT
hjic-110	342	5	1999	1999	NUM
hjic-110	342	6	,	,	PUNCT
hjic-110	342	7	182	182	NUM
hjic-110	342	8	,	,	PUNCT
hjic-110	342	9	33	33	NUM
hjic-110	342	10	-	-	SYM
hjic-110	342	11	39	39	NUM
hjic-110	342	12	40	40	NUM
hjic-110	342	13	.	.	PUNCT
hjic-110	343	1	kaczmarek	kaczmarek	PROPN
hjic-110	343	2	h.	h.	PROPN
hjic-110	343	3	,	,	PUNCT
hjic-110	343	4	szalla	szalla	NOUN
hjic-110	343	5	a.	a.	PROPN
hjic-110	343	6	,	,	PUNCT
hjic-110	343	7	kaminska	kaminska	PROPN
hjic-110	343	8	a.	a.	NOUN
hjic-110	343	9	:	:	PUNCT
hjic-110	343	10	polymer	polymer	NOUN
hjic-110	343	11	,	,	PUNCT
hjic-110	343	12	2001	2001	NUM
hjic-110	343	13	,	,	PUNCT
hjic-110	343	14	42	42	NUM
hjic-110	343	15	,	,	PUNCT
hjic-110	343	16	6057	6057	NUM
hjic-110	343	17	-	-	SYM
hjic-110	343	18	6069	6069	NUM
hjic-110	343	19	41	41	NUM
hjic-110	343	20	.	.	PUNCT
hjic-110	344	1	coates	coates	PROPN
hjic-110	344	2	j.	j.	PROPN
hjic-110	344	3	:	:	PUNCT
hjic-110	344	4	interpretation	interpretation	NOUN
hjic-110	344	5	of	of	ADP
hjic-110	344	6	infrared	infrared	PROPN
hjic-110	344	7	spectra	spectra	PROPN
hjic-110	344	8	,	,	PUNCT
hjic-110	344	9	a	a	DET
hjic-110	344	10	practical	practical	ADJ
hjic-110	344	11	approach	approach	NOUN
hjic-110	344	12	.	.	PUNCT
hjic-110	345	1	in	in	ADP
hjic-110	345	2	:	:	PUNCT
hjic-110	345	3	meyers	meyers	PROPN
hjic-110	345	4	r.a	r.a	PROPN
hjic-110	345	5	.	.	PROPN
hjic-110	345	6	:	:	PUNCT
hjic-110	346	1	encyclopedia	encyclopedia	NOUN
hjic-110	346	2	of	of	ADP
hjic-110	346	3	analytical	analytical	ADJ
hjic-110	346	4	chemistry	chemistry	NOUN
hjic-110	346	5	,	,	PUNCT
hjic-110	346	6	john	john	PROPN
hjic-110	346	7	wiley	wiley	PROPN
hjic-110	346	8	&	&	CCONJ
hjic-110	346	9	sons	sons	PROPN
hjic-110	346	10	ltd	ltd	PROPN
hjic-110	346	11	.	.	PROPN
hjic-110	346	12	,	,	PUNCT
hjic-110	346	13	chichester	chichester	PROPN
hjic-110	346	14	,	,	PUNCT
hjic-110	346	15	pp	pp	X
hjic-110	346	16	.	.	PUNCT
hjic-110	347	1	10815	10815	NUM
hjic-110	347	2	-	-	SYM
hjic-110	347	3	10837	10837	NUM
hjic-110	347	4	,	,	PUNCT
hjic-110	347	5	2000	2000	NUM
hjic-110	347	6	42	42	NUM
hjic-110	347	7	.	.	PUNCT
hjic-110	348	1	forster	forster	PROPN
hjic-110	348	2	a.	a.	PROPN
hjic-110	348	3	,	,	PUNCT
hjic-110	348	4	hempenstall	hempenstall	PROPN
hjic-110	348	5	j.	j.	PROPN
hjic-110	348	6	,	,	PUNCT
hjic-110	348	7	rades	rade	NOUN
hjic-110	348	8	t.	t.	PROPN
hjic-110	348	9	:	:	PUNCT
hjic-110	348	10	int	int	PROPN
hjic-110	348	11	.	.	PUNCT
hjic-110	349	1	j.	j.	PROPN
hjic-110	349	2	vib	vib	PROPN
hjic-110	349	3	.	.	PUNCT
hjic-110	349	4	spec	spec	PROPN
hjic-110	349	5	.	.	PUNCT
hjic-110	349	6	,	,	PUNCT
hjic-110	350	1	[	[	X
hjic-110	350	2	www.ijvs.com	www.ijvs.com	X
hjic-110	350	3	]	]	X
hjic-110	350	4	2001	2001	NUM
hjic-110	350	5	,	,	PUNCT
hjic-110	350	6	5	5	NUM
hjic-110	350	7	,	,	PUNCT
hjic-110	350	8	6	6	NUM
hjic-110	350	9	43	43	NUM
hjic-110	350	10	.	.	PUNCT
hjic-110	351	1	fda	fda	PROPN
hjic-110	351	2	,	,	PUNCT
hjic-110	351	3	1997	1997	NUM
hjic-110	351	4	.	.	PUNCT
hjic-110	352	1	international	international	ADJ
hjic-110	352	2	conference	conference	NOUN
hjic-110	352	3	on	on	ADP
hjic-110	352	4	harmonisation	harmonisation	NOUN
hjic-110	352	5	,	,	PUNCT
hjic-110	352	6	ich	ich	NOUN
hjic-110	352	7	guidance	guidance	NOUN
hjic-110	352	8	on	on	ADP
hjic-110	352	9	impurities	impurity	NOUN
hjic-110	352	10	:	:	PUNCT
hjic-110	352	11	residual	residual	ADJ
hjic-110	352	12	solvents	solvent	NOUN
hjic-110	352	13	,	,	PUNCT
hjic-110	352	14	federal	federal	ADJ
hjic-110	352	15	register	register	NOUN
hjic-110	352	16	.	.	PUNCT
hjic-110	353	1	62(247	62(247	PROPN
hjic-110	353	2	)	)	PUNCT
hjic-110	353	3	,	,	PUNCT
hjic-110	353	4	67377	67377	NUM
hjic-110	353	5	-	-	SYM
hjic-110	353	6	67388	67388	NUM
hjic-110	353	7	44	44	NUM
hjic-110	353	8	.	.	PUNCT
hjic-110	354	1	bristow	bristow	PROPN
hjic-110	354	2	s.	s.	PROPN
hjic-110	354	3	,	,	PUNCT
hjic-110	354	4	shekunov	shekunov	PROPN
hjic-110	354	5	t.	t.	PROPN
hjic-110	354	6	,	,	PUNCT
hjic-110	354	7	shekunov	shekunov	PROPN
hjic-110	354	8	b.	b.	PROPN
hjic-110	354	9	y.	y.	PROPN
hjic-110	354	10	,	,	PUNCT
hjic-110	354	11	york	york	PROPN
hjic-110	354	12	p.	p.	PROPN
hjic-110	354	13	:	:	PUNCT
hjic-110	354	14	j.	j.	PROPN
hjic-110	354	15	supercrit	supercrit	PROPN
hjic-110	354	16	.	.	PUNCT
hjic-110	354	17	fluids	fluid	NOUN
hjic-110	354	18	,	,	PUNCT
hjic-110	354	19	2001	2001	NUM
hjic-110	354	20	,	,	PUNCT
hjic-110	354	21	21	21	NUM
hjic-110	354	22	,	,	PUNCT
hjic-110	354	23	257	257	NUM
hjic-110	354	24	-	-	SYM
hjic-110	354	25	271	271	NUM
hjic-110	354	26	45	45	NUM
hjic-110	354	27	.	.	PUNCT
hjic-110	355	1	delneuville	delneuville	PROPN
hjic-110	355	2	i.	i.	PROPN
hjic-110	355	3	,	,	PUNCT
hjic-110	355	4	dechesne	dechesne	PROPN
hjic-110	355	5	j.	j.	PROPN
hjic-110	355	6	p.	p.	PROPN
hjic-110	355	7	,	,	PUNCT
hjic-110	355	8	delattre	delattre	PROPN
hjic-110	355	9	l.	l.	PROPN
hjic-110	355	10	:	:	PUNCT
hjic-110	355	11	int	int	PROPN
hjic-110	355	12	.	.	PUNCT
hjic-110	356	1	j.	j.	PROPN
hjic-110	356	2	pharm	pharm	PROPN
hjic-110	356	3	.	.	PUNCT
hjic-110	356	4	,	,	PUNCT
hjic-110	356	5	1998	1998	NUM
hjic-110	356	6	,	,	PUNCT
hjic-110	356	7	168	168	NUM
hjic-110	356	8	,	,	PUNCT
hjic-110	356	9	109	109	NUM
hjic-110	356	10	-	-	SYM
hjic-110	356	11	118	118	NUM
hjic-110	356	12	46	46	NUM
hjic-110	356	13	.	.	PUNCT
hjic-110	357	1	van	van	PROPN
hjic-110	357	2	den	den	PROPN
hjic-110	357	3	mooter	mooter	PROPN
hjic-110	357	4	g.	g.	NOUN
hjic-110	357	5	,	,	PUNCT
hjic-110	357	6	augustijns	augustijns	NOUN
hjic-110	357	7	p.	p.	PROPN
hjic-110	357	8	,	,	PUNCT
hjic-110	357	9	blaton	blaton	PROPN
hjic-110	357	10	n.	n.	PROPN
hjic-110	357	11	,	,	PUNCT
hjic-110	357	12	kinget	kinget	PROPN
hjic-110	357	13	r.	r.	PROPN
hjic-110	357	14	:	:	PUNCT
hjic-110	357	15	int	int	PROPN
hjic-110	357	16	.	.	PUNCT
hjic-110	358	1	j.	j.	PROPN
hjic-110	358	2	pharma	pharma	PROPN
hjic-110	358	3	.	.	PROPN
hjic-110	358	4	,	,	PUNCT
hjic-110	358	5	1998	1998	NUM
hjic-110	358	6	,	,	PUNCT
hjic-110	358	7	164	164	NUM
hjic-110	358	8	,	,	PUNCT
hjic-110	358	9	67	67	NUM
hjic-110	358	10	-	-	SYM
hjic-110	358	11	80	80	NUM
hjic-110	358	12	47	47	NUM
hjic-110	358	13	.	.	PUNCT
hjic-110	359	1	khougaz	khougaz	PROPN
hjic-110	359	2	k.	k.	PROPN
hjic-110	359	3	,	,	PUNCT
hjic-110	359	4	clas	clas	PROPN
hjic-110	359	5	s.-d	s.-d	PROPN
hjic-110	359	6	.	.	PUNCT
hjic-110	359	7	:	:	PUNCT
hjic-110	360	1	j.	j.	PROPN
hjic-110	360	2	pharm	pharm	PROPN
hjic-110	360	3	.	.	PUNCT
hjic-110	361	1	sci	sci	PROPN
hjic-110	361	2	.	.	PROPN
hjic-110	361	3	,	,	PUNCT
hjic-110	361	4	2000	2000	NUM
hjic-110	361	5	,	,	PUNCT
hjic-110	361	6	89	89	NUM
hjic-110	361	7	,	,	PUNCT
hjic-110	361	8	1325	1325	NUM
hjic-110	361	9	-	-	SYM
hjic-110	361	10	1334	1334	NUM
hjic-110	361	11	48	48	NUM
hjic-110	361	12	.	.	PUNCT
hjic-110	362	1	matsumoto	matsumoto	PROPN
hjic-110	362	2	t.	t.	PROPN
hjic-110	362	3	,	,	PUNCT
hjic-110	362	4	zografi	zografi	PROPN
hjic-110	362	5	g.	g.	PROPN
hjic-110	362	6	:	:	PUNCT
hjic-110	362	7	pharm	pharm	PROPN
hjic-110	362	8	.	.	PUNCT
hjic-110	363	1	res	re	NOUN
hjic-110	363	2	.	.	PROPN
hjic-110	363	3	,	,	PUNCT
hjic-110	363	4	1999	1999	NUM
hjic-110	363	5	,	,	PUNCT
hjic-110	363	6	16	16	NUM
hjic-110	363	7	,	,	PUNCT
hjic-110	363	8	1722	1722	NUM
hjic-110	363	9	-	-	SYM
hjic-110	363	10	1728	1728	NUM