id	sid	tid	token	lemma	pos
hjic-1161	1	1	hungarian	hungarian	ADJ
hjic-1161	1	2	journal	journal	NOUN
hjic-1161	1	3	of	of	ADP
hjic-1161	1	4	industry	industry	NOUN
hjic-1161	1	5	and	and	CCONJ
hjic-1161	1	6	chemistry	chemistry	NOUN
hjic-1161	1	7	vol	vol	NOUN
hjic-1161	1	8	.	.	PUNCT
hjic-1161	2	1	50	50	NUM
hjic-1161	2	2	pp	pp	NOUN
hjic-1161	2	3	.	.	PUNCT
hjic-1161	3	1	45–55	45–55	NUM
hjic-1161	3	2	(	(	PUNCT
hjic-1161	3	3	2022	2022	NUM
hjic-1161	3	4	)	)	PUNCT
hjic-1161	3	5	hjic.mk.uni-pannon.hu	hjic.mk.uni-pannon.hu	NOUN
hjic-1161	3	6	doi	doi	NOUN
hjic-1161	3	7	:	:	PUNCT
hjic-1161	3	8	10.33927	10.33927	NUM
hjic-1161	3	9	/	/	SYM
hjic-1161	3	10	hjic-2022	hjic-2022	NOUN
hjic-1161	3	11	-	-	PUNCT
hjic-1161	3	12	08	08	NUM
hjic-1161	3	13	enzyme	enzyme	NOUN
hjic-1161	3	14	reaction	reaction	NOUN
hjic-1161	3	15	engineering	engineering	NOUN
hjic-1161	3	16	as	as	ADP
hjic-1161	3	17	a	a	DET
hjic-1161	3	18	tool	tool	NOUN
hjic-1161	3	19	to	to	PART
hjic-1161	3	20	investigate	investigate	VERB
hjic-1161	3	21	the	the	DET
hjic-1161	3	22	potential	potential	ADJ
hjic-1161	3	23	application	application	NOUN
hjic-1161	3	24	of	of	ADP
hjic-1161	3	25	enzyme	enzyme	NOUN
hjic-1161	3	26	reaction	reaction	NOUN
hjic-1161	3	27	systems	system	NOUN
hjic-1161	3	28	nevena	nevena	VERB
hjic-1161	3	29	milčić	milčić	PROPN
hjic-1161	3	30	1	1	NUM
hjic-1161	3	31	,	,	PUNCT
hjic-1161	3	32	ivana	ivana	PROPN
hjic-1161	3	33	ćevid1	ćevid1	PROPN
hjic-1161	3	34	,	,	PUNCT
hjic-1161	3	35	mehmet	mehmet	PROPN
hjic-1161	3	36	mervan	mervan	PROPN
hjic-1161	3	37	çakar1	çakar1	PROPN
hjic-1161	3	38	,	,	PUNCT
hjic-1161	3	39	martina	martina	PROPN
hjic-1161	3	40	sudar1	sudar1	PROPN
hjic-1161	3	41	,	,	PUNCT
hjic-1161	3	42	and	and	CCONJ
hjic-1161	3	43	zvjezdana	zvjezdana	PROPN
hjic-1161	3	44	findrik	findrik	NOUN
hjic-1161	3	45	blažević	blažević	PUNCT
hjic-1161	4	1	*	*	PUNCT
hjic-1161	4	2	1	1	NUM
hjic-1161	4	3	1faculty	1faculty	NUM
hjic-1161	4	4	of	of	ADP
hjic-1161	4	5	chemical	chemical	ADJ
hjic-1161	4	6	engineering	engineering	NOUN
hjic-1161	4	7	and	and	CCONJ
hjic-1161	4	8	technology	technology	NOUN
hjic-1161	4	9	,	,	PUNCT
hjic-1161	4	10	university	university	PROPN
hjic-1161	4	11	of	of	ADP
hjic-1161	4	12	zagreb	zagreb	PROPN
hjic-1161	4	13	,	,	PUNCT
hjic-1161	4	14	marulićev	marulićev	PROPN
hjic-1161	4	15	trg	trg	PROPN
hjic-1161	4	16	19	19	NUM
hjic-1161	4	17	,	,	PUNCT
hjic-1161	4	18	zagreb	zagreb	PROPN
hjic-1161	4	19	,	,	PUNCT
hjic-1161	4	20	hr-10000	hr-10000	PROPN
hjic-1161	4	21	,	,	PUNCT
hjic-1161	4	22	croatia	croatia	PROPN
hjic-1161	4	23	it	it	PRON
hjic-1161	4	24	is	be	AUX
hjic-1161	4	25	widely	widely	ADV
hjic-1161	4	26	recognized	recognize	VERB
hjic-1161	4	27	and	and	CCONJ
hjic-1161	4	28	accepted	accept	VERB
hjic-1161	4	29	that	that	SCONJ
hjic-1161	4	30	although	although	SCONJ
hjic-1161	4	31	biocatalysis	biocatalysis	NOUN
hjic-1161	4	32	is	be	AUX
hjic-1161	4	33	an	an	DET
hjic-1161	4	34	exquisite	exquisite	ADJ
hjic-1161	4	35	tool	tool	NOUN
hjic-1161	4	36	to	to	PART
hjic-1161	4	37	synthesize	synthesize	VERB
hjic-1161	4	38	natural	natural	ADJ
hjic-1161	4	39	and	and	CCONJ
hjic-1161	4	40	unnatural	unnatural	ADJ
hjic-1161	4	41	compounds	compound	NOUN
hjic-1161	4	42	under	under	ADP
hjic-1161	4	43	mild	mild	ADJ
hjic-1161	4	44	process	process	NOUN
hjic-1161	4	45	conditions	condition	NOUN
hjic-1161	4	46	,	,	PUNCT
hjic-1161	4	47	much	much	ADJ
hjic-1161	4	48	can	can	AUX
hjic-1161	4	49	be	be	AUX
hjic-1161	4	50	done	do	VERB
hjic-1161	4	51	to	to	PART
hjic-1161	4	52	better	well	ADV
hjic-1161	4	53	understand	understand	VERB
hjic-1161	4	54	these	these	DET
hjic-1161	4	55	processes	process	NOUN
hjic-1161	4	56	as	as	ADV
hjic-1161	4	57	well	well	ADV
hjic-1161	4	58	as	as	ADP
hjic-1161	4	59	detect	detect	VERB
hjic-1161	4	60	resulting	result	VERB
hjic-1161	4	61	bottlenecks	bottleneck	NOUN
hjic-1161	4	62	and	and	CCONJ
hjic-1161	4	63	help	help	VERB
hjic-1161	4	64	to	to	PART
hjic-1161	4	65	resolve	resolve	VERB
hjic-1161	4	66	them	they	PRON
hjic-1161	4	67	.	.	PUNCT
hjic-1161	5	1	this	this	PRON
hjic-1161	5	2	is	be	AUX
hjic-1161	5	3	the	the	DET
hjic-1161	5	4	precise	precise	ADJ
hjic-1161	5	5	purpose	purpose	NOUN
hjic-1161	5	6	of	of	ADP
hjic-1161	5	7	enzyme	enzyme	NOUN
hjic-1161	5	8	reaction	reaction	NOUN
hjic-1161	5	9	engineering	engineering	NOUN
hjic-1161	5	10	,	,	PUNCT
hjic-1161	5	11	a	a	DET
hjic-1161	5	12	scientific	scientific	ADJ
hjic-1161	5	13	discipline	discipline	NOUN
hjic-1161	5	14	that	that	PRON
hjic-1161	5	15	focuses	focus	VERB
hjic-1161	5	16	on	on	ADP
hjic-1161	5	17	investigating	investigate	VERB
hjic-1161	5	18	enzyme	enzyme	NOUN
hjic-1161	5	19	reactions	reaction	NOUN
hjic-1161	5	20	with	with	ADP
hjic-1161	5	21	the	the	DET
hjic-1161	5	22	goal	goal	NOUN
hjic-1161	5	23	of	of	ADP
hjic-1161	5	24	facilitating	facilitate	VERB
hjic-1161	5	25	their	their	PRON
hjic-1161	5	26	implementation	implementation	NOUN
hjic-1161	5	27	on	on	ADP
hjic-1161	5	28	an	an	DET
hjic-1161	5	29	industrial	industrial	ADJ
hjic-1161	5	30	scale	scale	NOUN
hjic-1161	5	31	.	.	PUNCT
hjic-1161	6	1	even	even	ADV
hjic-1161	6	2	though	though	SCONJ
hjic-1161	6	3	reaction	reaction	NOUN
hjic-1161	6	4	schemes	scheme	NOUN
hjic-1161	6	5	of	of	ADP
hjic-1161	6	6	enzyme	enzyme	NOUN
hjic-1161	6	7	reactions	reaction	NOUN
hjic-1161	6	8	often	often	ADV
hjic-1161	6	9	seem	seem	VERB
hjic-1161	6	10	simple	simple	ADJ
hjic-1161	6	11	,	,	PUNCT
hjic-1161	6	12	in	in	ADP
hjic-1161	6	13	practice	practice	NOUN
hjic-1161	6	14	,	,	PUNCT
hjic-1161	6	15	the	the	DET
hjic-1161	6	16	interdependence	interdependence	NOUN
hjic-1161	6	17	of	of	ADP
hjic-1161	6	18	different	different	ADJ
hjic-1161	6	19	variables	variable	NOUN
hjic-1161	6	20	is	be	AUX
hjic-1161	6	21	unknown	unknown	ADJ
hjic-1161	6	22	,	,	PUNCT
hjic-1161	6	23	very	very	ADV
hjic-1161	6	24	complex	complex	ADJ
hjic-1161	6	25	and	and	CCONJ
hjic-1161	6	26	may	may	AUX
hjic-1161	6	27	prevent	prevent	VERB
hjic-1161	6	28	further	further	ADJ
hjic-1161	6	29	applications	application	NOUN
hjic-1161	6	30	.	.	PUNCT
hjic-1161	7	1	therefore	therefore	ADV
hjic-1161	7	2	,	,	PUNCT
hjic-1161	7	3	in	in	ADP
hjic-1161	7	4	this	this	DET
hjic-1161	7	5	work	work	NOUN
hjic-1161	7	6	,	,	PUNCT
hjic-1161	7	7	important	important	ADJ
hjic-1161	7	8	aspects	aspect	NOUN
hjic-1161	7	9	of	of	ADP
hjic-1161	7	10	the	the	DET
hjic-1161	7	11	implementation	implementation	NOUN
hjic-1161	7	12	of	of	ADP
hjic-1161	7	13	enzyme	enzyme	NOUN
hjic-1161	7	14	reactions	reaction	NOUN
hjic-1161	7	15	are	be	AUX
hjic-1161	7	16	discussed	discuss	VERB
hjic-1161	7	17	using	use	VERB
hjic-1161	7	18	simple	simple	ADJ
hjic-1161	7	19	and	and	CCONJ
hjic-1161	7	20	complex	complex	ADJ
hjic-1161	7	21	examples	example	NOUN
hjic-1161	7	22	,	,	PUNCT
hjic-1161	7	23	along	along	ADP
hjic-1161	7	24	with	with	ADP
hjic-1161	7	25	principles	principle	NOUN
hjic-1161	7	26	of	of	ADP
hjic-1161	7	27	mathematical	mathematical	ADJ
hjic-1161	7	28	modelling	modelling	NOUN
hjic-1161	7	29	that	that	PRON
hjic-1161	7	30	provide	provide	VERB
hjic-1161	7	31	explanations	explanation	NOUN
hjic-1161	7	32	for	for	ADP
hjic-1161	7	33	why	why	SCONJ
hjic-1161	7	34	some	some	DET
hjic-1161	7	35	reactions	reaction	NOUN
hjic-1161	7	36	do	do	AUX
hjic-1161	7	37	not	not	PART
hjic-1161	7	38	proceed	proceed	VERB
hjic-1161	7	39	as	as	SCONJ
hjic-1161	7	40	planned	plan	VERB
hjic-1161	7	41	.	.	PUNCT
hjic-1161	8	1	keywords	keyword	NOUN
hjic-1161	8	2	:	:	PUNCT
hjic-1161	8	3	enzyme	enzyme	NOUN
hjic-1161	8	4	kinetics	kinetic	NOUN
hjic-1161	8	5	,	,	PUNCT
hjic-1161	8	6	modelling	modelling	NOUN
hjic-1161	8	7	,	,	PUNCT
hjic-1161	8	8	reaction	reaction	NOUN
hjic-1161	8	9	optimisation	optimisation	NOUN
hjic-1161	8	10	1	1	NUM
hjic-1161	8	11	.	.	PUNCT
hjic-1161	8	12	setting	set	VERB
hjic-1161	8	13	up	up	ADP
hjic-1161	8	14	the	the	DET
hjic-1161	8	15	reaction	reaction	NOUN
hjic-1161	8	16	conditions	condition	NOUN
hjic-1161	8	17	for	for	ADP
hjic-1161	8	18	an	an	DET
hjic-1161	8	19	enzyme	enzyme	NOUN
hjic-1161	8	20	reaction	reaction	NOUN
hjic-1161	8	21	in	in	ADP
hjic-1161	8	22	each	each	DET
hjic-1161	8	23	reaction	reaction	NOUN
hjic-1161	8	24	system	system	NOUN
hjic-1161	8	25	,	,	PUNCT
hjic-1161	8	26	first	first	ADV
hjic-1161	8	27	a	a	DET
hjic-1161	8	28	proper	proper	ADJ
hjic-1161	8	29	buffer	buffer	NOUN
hjic-1161	8	30	must	must	AUX
hjic-1161	8	31	be	be	AUX
hjic-1161	8	32	selected	select	VERB
hjic-1161	8	33	and	and	CCONJ
hjic-1161	8	34	the	the	DET
hjic-1161	8	35	ph	ph	ADJ
hjic-1161	8	36	dependence	dependence	NOUN
hjic-1161	8	37	of	of	ADP
hjic-1161	8	38	the	the	DET
hjic-1161	8	39	enzyme	enzyme	NOUN
hjic-1161	8	40	activity	activity	NOUN
hjic-1161	8	41	determined	determine	VERB
hjic-1161	8	42	in	in	ADP
hjic-1161	8	43	order	order	NOUN
hjic-1161	8	44	to	to	PART
hjic-1161	8	45	identify	identify	VERB
hjic-1161	8	46	the	the	DET
hjic-1161	8	47	optimal	optimal	ADJ
hjic-1161	8	48	working	working	NOUN
hjic-1161	8	49	conditions	condition	NOUN
hjic-1161	8	50	[	[	X
hjic-1161	8	51	1	1	NUM
hjic-1161	8	52	]	]	PUNCT
hjic-1161	8	53	.	.	PUNCT
hjic-1161	9	1	although	although	SCONJ
hjic-1161	9	2	the	the	DET
hjic-1161	9	3	impact	impact	NOUN
hjic-1161	9	4	of	of	ADP
hjic-1161	9	5	temperature	temperature	NOUN
hjic-1161	9	6	on	on	ADP
hjic-1161	9	7	enzyme	enzyme	NOUN
hjic-1161	9	8	activity	activity	NOUN
hjic-1161	9	9	is	be	AUX
hjic-1161	9	10	also	also	ADV
hjic-1161	9	11	important	important	ADJ
hjic-1161	9	12	,	,	PUNCT
hjic-1161	9	13	it	it	PRON
hjic-1161	9	14	should	should	AUX
hjic-1161	9	15	be	be	AUX
hjic-1161	9	16	remembered	remember	VERB
hjic-1161	9	17	that	that	SCONJ
hjic-1161	9	18	the	the	DET
hjic-1161	9	19	temperature	temperature	NOUN
hjic-1161	9	20	at	at	ADP
hjic-1161	9	21	which	which	PRON
hjic-1161	9	22	the	the	DET
hjic-1161	9	23	enzyme	enzyme	NOUN
hjic-1161	9	24	exhibits	exhibit	VERB
hjic-1161	9	25	the	the	DET
hjic-1161	9	26	highest	high	ADJ
hjic-1161	9	27	level	level	NOUN
hjic-1161	9	28	of	of	ADP
hjic-1161	9	29	activity	activity	NOUN
hjic-1161	9	30	is	be	AUX
hjic-1161	9	31	not	not	PART
hjic-1161	9	32	necessarily	necessarily	ADV
hjic-1161	9	33	that	that	PRON
hjic-1161	9	34	at	at	ADP
hjic-1161	9	35	which	which	PRON
hjic-1161	9	36	the	the	DET
hjic-1161	9	37	enzyme	enzyme	NOUN
hjic-1161	9	38	stability	stability	NOUN
hjic-1161	9	39	is	be	AUX
hjic-1161	9	40	optimal	optimal	ADJ
hjic-1161	9	41	.	.	PUNCT
hjic-1161	10	1	at	at	ADP
hjic-1161	10	2	higher	high	ADJ
hjic-1161	10	3	temperatures	temperature	NOUN
hjic-1161	10	4	,	,	PUNCT
hjic-1161	10	5	the	the	DET
hjic-1161	10	6	enzyme	enzyme	NOUN
hjic-1161	10	7	activity	activity	NOUN
hjic-1161	10	8	is	be	AUX
hjic-1161	10	9	often	often	ADV
hjic-1161	10	10	increased	increase	VERB
hjic-1161	10	11	but	but	CCONJ
hjic-1161	10	12	at	at	ADP
hjic-1161	10	13	the	the	DET
hjic-1161	10	14	cost	cost	NOUN
hjic-1161	10	15	of	of	ADP
hjic-1161	10	16	progressive	progressive	ADJ
hjic-1161	10	17	and	and	CCONJ
hjic-1161	10	18	irreversible	irreversible	ADJ
hjic-1161	10	19	denaturation	denaturation	NOUN
hjic-1161	10	20	due	due	ADP
hjic-1161	10	21	to	to	ADP
hjic-1161	10	22	poor	poor	ADJ
hjic-1161	10	23	thermal	thermal	ADJ
hjic-1161	10	24	stability	stability	NOUN
hjic-1161	10	25	[	[	X
hjic-1161	10	26	2,3	2,3	NUM
hjic-1161	10	27	]	]	PUNCT
hjic-1161	10	28	.	.	PUNCT
hjic-1161	11	1	when	when	SCONJ
hjic-1161	11	2	multiple	multiple	ADJ
hjic-1161	11	3	enzymes	enzyme	NOUN
hjic-1161	11	4	are	be	AUX
hjic-1161	11	5	present	present	ADJ
hjic-1161	11	6	in	in	ADP
hjic-1161	11	7	the	the	DET
hjic-1161	11	8	reaction	reaction	NOUN
hjic-1161	11	9	system	system	NOUN
hjic-1161	11	10	and	and	CCONJ
hjic-1161	11	11	are	be	AUX
hjic-1161	11	12	supposed	suppose	VERB
hjic-1161	11	13	to	to	PART
hjic-1161	11	14	operate	operate	VERB
hjic-1161	11	15	in	in	ADP
hjic-1161	11	16	the	the	DET
hjic-1161	11	17	same	same	ADJ
hjic-1161	11	18	reactor	reactor	NOUN
hjic-1161	11	19	,	,	PUNCT
hjic-1161	11	20	as	as	SCONJ
hjic-1161	11	21	is	be	AUX
hjic-1161	11	22	the	the	DET
hjic-1161	11	23	case	case	NOUN
hjic-1161	11	24	in	in	ADP
hjic-1161	11	25	cascade	cascade	NOUN
hjic-1161	11	26	reactions	reaction	NOUN
hjic-1161	11	27	,	,	PUNCT
hjic-1161	11	28	the	the	DET
hjic-1161	11	29	optimal	optimal	ADJ
hjic-1161	11	30	conditions	condition	NOUN
hjic-1161	11	31	can	can	AUX
hjic-1161	11	32	seldom	seldom	ADV
hjic-1161	11	33	be	be	AUX
hjic-1161	11	34	chosen	choose	VERB
hjic-1161	11	35	for	for	ADP
hjic-1161	11	36	all	all	PRON
hjic-1161	11	37	of	of	ADP
hjic-1161	11	38	them	they	PRON
hjic-1161	11	39	.	.	PUNCT
hjic-1161	12	1	usually	usually	ADV
hjic-1161	12	2	,	,	PUNCT
hjic-1161	12	3	a	a	DET
hjic-1161	12	4	compromise	compromise	NOUN
hjic-1161	12	5	must	must	AUX
hjic-1161	12	6	be	be	AUX
hjic-1161	12	7	reached	reach	VERB
hjic-1161	12	8	whereby	whereby	SCONJ
hjic-1161	12	9	the	the	DET
hjic-1161	12	10	selection	selection	NOUN
hjic-1161	12	11	of	of	ADP
hjic-1161	12	12	the	the	DET
hjic-1161	12	13	reaction	reaction	NOUN
hjic-1161	12	14	conditions	condition	NOUN
hjic-1161	12	15	depends	depend	VERB
hjic-1161	12	16	on	on	ADP
hjic-1161	12	17	the	the	DET
hjic-1161	12	18	enzyme	enzyme	NOUN
hjic-1161	12	19	activity	activity	NOUN
hjic-1161	12	20	required	require	VERB
hjic-1161	12	21	to	to	PART
hjic-1161	12	22	catalyse	catalyse	VERB
hjic-1161	12	23	the	the	DET
hjic-1161	12	24	reaction	reaction	NOUN
hjic-1161	12	25	[	[	X
hjic-1161	12	26	4	4	NUM
hjic-1161	12	27	,	,	PUNCT
hjic-1161	12	28	5	5	NUM
hjic-1161	12	29	]	]	PUNCT
hjic-1161	12	30	.	.	PUNCT
hjic-1161	13	1	after	after	ADP
hjic-1161	13	2	selecting	select	VERB
hjic-1161	13	3	the	the	DET
hjic-1161	13	4	buffer	buffer	NOUN
hjic-1161	13	5	,	,	PUNCT
hjic-1161	13	6	temperature	temperature	NOUN
hjic-1161	13	7	and	and	CCONJ
hjic-1161	13	8	ph	ph	NOUN
hjic-1161	13	9	for	for	ADP
hjic-1161	13	10	the	the	DET
hjic-1161	13	11	studied	study	VERB
hjic-1161	13	12	reaction	reaction	NOUN
hjic-1161	13	13	system	system	NOUN
hjic-1161	13	14	,	,	PUNCT
hjic-1161	13	15	it	it	PRON
hjic-1161	13	16	must	must	AUX
hjic-1161	13	17	be	be	AUX
hjic-1161	13	18	analysed	analyse	VERB
hjic-1161	13	19	in	in	ADP
hjic-1161	13	20	detail	detail	NOUN
hjic-1161	13	21	,	,	PUNCT
hjic-1161	13	22	starting	start	VERB
hjic-1161	13	23	from	from	ADP
hjic-1161	13	24	the	the	DET
hjic-1161	13	25	reaction	reaction	NOUN
hjic-1161	13	26	scheme	scheme	NOUN
hjic-1161	13	27	.	.	PUNCT
hjic-1161	14	1	even	even	ADV
hjic-1161	14	2	though	though	SCONJ
hjic-1161	14	3	the	the	DET
hjic-1161	14	4	reaction	reaction	NOUN
hjic-1161	14	5	scheme	scheme	NOUN
hjic-1161	14	6	usually	usually	ADV
hjic-1161	14	7	clearly	clearly	ADV
hjic-1161	14	8	depicts	depict	VERB
hjic-1161	14	9	the	the	DET
hjic-1161	14	10	reaction	reaction	NOUN
hjic-1161	14	11	,	,	PUNCT
hjic-1161	14	12	it	it	PRON
hjic-1161	14	13	should	should	AUX
hjic-1161	14	14	be	be	AUX
hjic-1161	14	15	noted	note	VERB
hjic-1161	14	16	that	that	SCONJ
hjic-1161	14	17	recieved	recieve	VERB
hjic-1161	14	18	:	:	PUNCT
hjic-1161	14	19	4	4	NUM
hjic-1161	14	20	april	april	PROPN
hjic-1161	14	21	2022	2022	NUM
hjic-1161	14	22	;	;	PUNCT
hjic-1161	14	23	revised	revise	VERB
hjic-1161	14	24	:	:	PUNCT
hjic-1161	14	25	10	10	NUM
hjic-1161	14	26	april	april	PROPN
hjic-1161	14	27	2022	2022	NUM
hjic-1161	14	28	;	;	PUNCT
hjic-1161	14	29	accepted	accept	VERB
hjic-1161	14	30	:	:	PUNCT
hjic-1161	14	31	11	11	NUM
hjic-1161	14	32	april	april	PROPN
hjic-1161	14	33	2022	2022	NUM
hjic-1161	14	34	*	*	PUNCT
hjic-1161	14	35	correspondence	correspondence	NOUN
hjic-1161	14	36	:	:	PUNCT
hjic-1161	14	37	zfindrik@fkit.hr	zfindrik@fkit.hr	PROPN
hjic-1161	14	38	issues	issue	NOUN
hjic-1161	14	39	beyond	beyond	ADP
hjic-1161	14	40	the	the	DET
hjic-1161	14	41	reaction	reaction	NOUN
hjic-1161	14	42	scheme	scheme	NOUN
hjic-1161	14	43	of	of	ADP
hjic-1161	14	44	the	the	DET
hjic-1161	14	45	enzymatic	enzymatic	ADJ
hjic-1161	14	46	reaction	reaction	NOUN
hjic-1161	14	47	need	need	VERB
hjic-1161	14	48	to	to	PART
hjic-1161	14	49	be	be	AUX
hjic-1161	14	50	discussed	discuss	VERB
hjic-1161	14	51	and	and	CCONJ
hjic-1161	14	52	analysed	analyse	VERB
hjic-1161	14	53	.	.	PUNCT
hjic-1161	15	1	in	in	ADP
hjic-1161	15	2	many	many	ADJ
hjic-1161	15	3	cases	case	NOUN
hjic-1161	15	4	,	,	PUNCT
hjic-1161	15	5	unwanted	unwanted	ADJ
hjic-1161	15	6	but	but	CCONJ
hjic-1161	15	7	insignificant	insignificant	ADJ
hjic-1161	15	8	side	side	NOUN
hjic-1161	15	9	reactions	reaction	NOUN
hjic-1161	15	10	may	may	AUX
hjic-1161	15	11	take	take	VERB
hjic-1161	15	12	place	place	NOUN
hjic-1161	15	13	that	that	PRON
hjic-1161	15	14	sometimes	sometimes	ADV
hjic-1161	15	15	also	also	ADV
hjic-1161	15	16	have	have	VERB
hjic-1161	15	17	a	a	DET
hjic-1161	15	18	detrimental	detrimental	ADJ
hjic-1161	15	19	effect	effect	NOUN
hjic-1161	15	20	on	on	ADP
hjic-1161	15	21	the	the	DET
hjic-1161	15	22	outcome	outcome	NOUN
hjic-1161	15	23	of	of	ADP
hjic-1161	15	24	the	the	DET
hjic-1161	15	25	reaction	reaction	NOUN
hjic-1161	15	26	.	.	PUNCT
hjic-1161	16	1	although	although	SCONJ
hjic-1161	16	2	this	this	PRON
hjic-1161	16	3	may	may	AUX
hjic-1161	16	4	not	not	PART
hjic-1161	16	5	be	be	AUX
hjic-1161	16	6	so	so	ADV
hjic-1161	16	7	important	important	ADJ
hjic-1161	16	8	on	on	ADP
hjic-1161	16	9	the	the	DET
hjic-1161	16	10	laboratory	laboratory	NOUN
hjic-1161	16	11	scale	scale	NOUN
hjic-1161	16	12	as	as	ADV
hjic-1161	16	13	far	far	ADV
hjic-1161	16	14	as	as	SCONJ
hjic-1161	16	15	screening	screen	VERB
hjic-1161	16	16	for	for	ADP
hjic-1161	16	17	enzyme	enzyme	NOUN
hjic-1161	16	18	activities	activity	NOUN
hjic-1161	16	19	is	be	AUX
hjic-1161	16	20	concerned	concern	VERB
hjic-1161	16	21	,	,	PUNCT
hjic-1161	16	22	given	give	VERB
hjic-1161	16	23	that	that	SCONJ
hjic-1161	16	24	the	the	DET
hjic-1161	16	25	concentrations	concentration	NOUN
hjic-1161	16	26	applied	apply	VERB
hjic-1161	16	27	on	on	ADP
hjic-1161	16	28	that	that	DET
hjic-1161	16	29	scale	scale	NOUN
hjic-1161	16	30	fall	fall	NOUN
hjic-1161	16	31	within	within	ADP
hjic-1161	16	32	the	the	DET
hjic-1161	16	33	range	range	NOUN
hjic-1161	16	34	of	of	ADP
hjic-1161	16	35	a	a	DET
hjic-1161	16	36	few	few	ADJ
hjic-1161	16	37	mm	mm	NOUN
hjic-1161	16	38	,	,	PUNCT
hjic-1161	16	39	it	it	PRON
hjic-1161	16	40	must	must	AUX
hjic-1161	16	41	be	be	AUX
hjic-1161	16	42	noted	note	VERB
hjic-1161	16	43	that	that	SCONJ
hjic-1161	16	44	the	the	DET
hjic-1161	16	45	rate	rate	NOUN
hjic-1161	16	46	of	of	ADP
hjic-1161	16	47	chemical	chemical	ADJ
hjic-1161	16	48	reactions	reaction	NOUN
hjic-1161	16	49	increases	increase	VERB
hjic-1161	16	50	as	as	ADP
hjic-1161	16	51	the	the	DET
hjic-1161	16	52	concentration	concentration	NOUN
hjic-1161	16	53	of	of	ADP
hjic-1161	16	54	reactants	reactant	NOUN
hjic-1161	16	55	increases	increase	NOUN
hjic-1161	16	56	,	,	PUNCT
hjic-1161	16	57	e.g.	e.g.	ADV
hjic-1161	16	58	firstand	firstand	ADJ
hjic-1161	16	59	second	second	ADJ
hjic-1161	16	60	-	-	PUNCT
hjic-1161	16	61	order	order	NOUN
hjic-1161	16	62	reactions	reaction	NOUN
hjic-1161	16	63	.	.	PUNCT
hjic-1161	17	1	therefore	therefore	ADV
hjic-1161	17	2	,	,	PUNCT
hjic-1161	17	3	further	further	ADJ
hjic-1161	17	4	analyses	analysis	NOUN
hjic-1161	17	5	to	to	PART
hjic-1161	17	6	determine	determine	VERB
hjic-1161	17	7	the	the	DET
hjic-1161	17	8	effect	effect	NOUN
hjic-1161	17	9	of	of	ADP
hjic-1161	17	10	increasing	increase	VERB
hjic-1161	17	11	the	the	DET
hjic-1161	17	12	scale	scale	NOUN
hjic-1161	17	13	of	of	ADP
hjic-1161	17	14	the	the	DET
hjic-1161	17	15	reaction	reaction	NOUN
hjic-1161	17	16	by	by	ADP
hjic-1161	17	17	hundreds	hundred	NOUN
hjic-1161	17	18	of	of	ADP
hjic-1161	17	19	mm	mm	NUM
hjic-1161	17	20	are	be	AUX
hjic-1161	17	21	required	require	VERB
hjic-1161	17	22	.	.	PUNCT
hjic-1161	18	1	the	the	DET
hjic-1161	18	2	same	same	ADJ
hjic-1161	18	3	applies	apply	VERB
hjic-1161	18	4	to	to	ADP
hjic-1161	18	5	the	the	DET
hjic-1161	18	6	chemical	chemical	NOUN
hjic-1161	18	7	stability	stability	NOUN
hjic-1161	18	8	of	of	ADP
hjic-1161	18	9	compounds	compound	NOUN
hjic-1161	18	10	present	present	ADJ
hjic-1161	18	11	in	in	ADP
hjic-1161	18	12	the	the	DET
hjic-1161	18	13	reactor	reactor	NOUN
hjic-1161	18	14	.	.	PUNCT
hjic-1161	19	1	in	in	ADP
hjic-1161	19	2	this	this	DET
hjic-1161	19	3	case	case	NOUN
hjic-1161	19	4	,	,	PUNCT
hjic-1161	19	5	engineering	engineering	NOUN
hjic-1161	19	6	methodology	methodology	NOUN
hjic-1161	19	7	is	be	AUX
hjic-1161	19	8	priceless	priceless	ADJ
hjic-1161	19	9	for	for	ADP
hjic-1161	19	10	the	the	DET
hjic-1161	19	11	purpose	purpose	NOUN
hjic-1161	19	12	of	of	ADP
hjic-1161	19	13	exploring	explore	VERB
hjic-1161	19	14	the	the	DET
hjic-1161	19	15	possibility	possibility	NOUN
hjic-1161	19	16	of	of	ADP
hjic-1161	19	17	slowly	slowly	ADV
hjic-1161	19	18	feeding	feed	VERB
hjic-1161	19	19	the	the	DET
hjic-1161	19	20	reactive	reactive	NOUN
hjic-1161	19	21	compound	compound	NOUN
hjic-1161	19	22	into	into	ADP
hjic-1161	19	23	the	the	DET
hjic-1161	19	24	reactor	reactor	NOUN
hjic-1161	19	25	.	.	PUNCT
hjic-1161	20	1	alternatively	alternatively	ADV
hjic-1161	20	2	,	,	PUNCT
hjic-1161	20	3	if	if	SCONJ
hjic-1161	20	4	an	an	DET
hjic-1161	20	5	intermediate	intermediate	NOUN
hjic-1161	20	6	is	be	AUX
hjic-1161	20	7	reactive	reactive	ADJ
hjic-1161	20	8	,	,	PUNCT
hjic-1161	20	9	the	the	DET
hjic-1161	20	10	reaction	reaction	NOUN
hjic-1161	20	11	rate	rate	NOUN
hjic-1161	20	12	in	in	ADP
hjic-1161	20	13	the	the	DET
hjic-1161	20	14	reactor	reactor	NOUN
hjic-1161	20	15	may	may	AUX
hjic-1161	20	16	be	be	AUX
hjic-1161	20	17	tuned	tune	VERB
hjic-1161	20	18	to	to	PART
hjic-1161	20	19	ensure	ensure	VERB
hjic-1161	20	20	its	its	PRON
hjic-1161	20	21	concentration	concentration	NOUN
hjic-1161	20	22	is	be	AUX
hjic-1161	20	23	always	always	ADV
hjic-1161	20	24	minimal	minimal	ADJ
hjic-1161	20	25	.	.	PUNCT
hjic-1161	21	1	for	for	ADP
hjic-1161	21	2	example	example	NOUN
hjic-1161	21	3	,	,	PUNCT
hjic-1161	21	4	in	in	ADP
hjic-1161	21	5	the	the	DET
hjic-1161	21	6	case	case	NOUN
hjic-1161	21	7	of	of	ADP
hjic-1161	21	8	epoxides	epoxide	NOUN
hjic-1161	21	9	that	that	PRON
hjic-1161	21	10	are	be	AUX
hjic-1161	21	11	substrates	substrate	NOUN
hjic-1161	21	12	of	of	ADP
hjic-1161	21	13	halohydrin	halohydrin	NOUN
hjic-1161	21	14	dehalogenases	dehalogenase	NOUN
hjic-1161	21	15	[	[	X
hjic-1161	21	16	6	6	NUM
hjic-1161	21	17	]	]	PUNCT
hjic-1161	21	18	,	,	PUNCT
hjic-1161	21	19	it	it	PRON
hjic-1161	21	20	is	be	AUX
hjic-1161	21	21	known	know	VERB
hjic-1161	21	22	that	that	SCONJ
hjic-1161	21	23	their	their	PRON
hjic-1161	21	24	stability	stability	NOUN
hjic-1161	21	25	is	be	AUX
hjic-1161	21	26	poor	poor	ADJ
hjic-1161	21	27	[	[	X
hjic-1161	21	28	7,8	7,8	NUM
hjic-1161	21	29	]	]	PUNCT
hjic-1161	21	30	.	.	PUNCT
hjic-1161	22	1	as	as	ADP
hjic-1161	22	2	a	a	DET
hjic-1161	22	3	result	result	NOUN
hjic-1161	22	4	,	,	PUNCT
hjic-1161	22	5	in	in	ADP
hjic-1161	22	6	these	these	DET
hjic-1161	22	7	reactions	reaction	NOUN
hjic-1161	22	8	,	,	PUNCT
hjic-1161	22	9	a	a	DET
hjic-1161	22	10	prochiral	prochiral	ADJ
hjic-1161	22	11	substrate	substrate	NOUN
hjic-1161	22	12	is	be	AUX
hjic-1161	22	13	often	often	ADV
hjic-1161	22	14	used	use	VERB
hjic-1161	22	15	to	to	PART
hjic-1161	22	16	start	start	VERB
hjic-1161	22	17	the	the	DET
hjic-1161	22	18	reaction	reaction	NOUN
hjic-1161	22	19	[	[	X
hjic-1161	22	20	9,10	9,10	NUM
hjic-1161	22	21	]	]	X
hjic-1161	22	22	.	.	PUNCT
hjic-1161	23	1	the	the	DET
hjic-1161	23	2	same	same	ADJ
hjic-1161	23	3	is	be	AUX
hjic-1161	23	4	true	true	ADJ
hjic-1161	23	5	in	in	ADP
hjic-1161	23	6	this	this	DET
hjic-1161	23	7	case	case	NOUN
hjic-1161	23	8	whereby	whereby	SCONJ
hjic-1161	23	9	an	an	DET
hjic-1161	23	10	epoxide	epoxide	NOUN
hjic-1161	23	11	intermediate	intermediate	NOUN
hjic-1161	23	12	is	be	AUX
hjic-1161	23	13	formed	form	VERB
hjic-1161	23	14	in	in	ADP
hjic-1161	23	15	situ	situ	NOUN
hjic-1161	23	16	and	and	CCONJ
hjic-1161	23	17	immediately	immediately	ADV
hjic-1161	23	18	spent	spend	VERB
hjic-1161	23	19	in	in	ADP
hjic-1161	23	20	the	the	DET
hjic-1161	23	21	subsequent	subsequent	ADJ
hjic-1161	23	22	reaction	reaction	NOUN
hjic-1161	23	23	with	with	ADP
hjic-1161	23	24	the	the	DET
hjic-1161	23	25	same	same	ADJ
hjic-1161	23	26	or	or	CCONJ
hjic-1161	23	27	a	a	DET
hjic-1161	23	28	different	different	ADJ
hjic-1161	23	29	enzyme	enzyme	NOUN
hjic-1161	23	30	such	such	ADJ
hjic-1161	23	31	as	as	ADP
hjic-1161	23	32	the	the	DET
hjic-1161	23	33	one	one	NOUN
hjic-1161	23	34	presented	present	VERB
hjic-1161	23	35	in	in	ADP
hjic-1161	23	36	scheme	scheme	NOUN
hjic-1161	23	37	1	1	NUM
hjic-1161	23	38	.	.	PUNCT
hjic-1161	23	39	additionally	additionally	ADV
hjic-1161	23	40	,	,	PUNCT
hjic-1161	23	41	since	since	SCONJ
hjic-1161	23	42	both	both	DET
hjic-1161	23	43	epoxides	epoxide	NOUN
hjic-1161	23	44	and	and	CCONJ
hjic-1161	23	45	their	their	PRON
hjic-1161	23	46	correhttps://doi.org/10.33927/hjic-2022-08	correhttps://doi.org/10.33927/hjic-2022-08	NOUN
hjic-1161	23	47	mailto:zfindrik@fkit.hr	mailto:zfindrik@fkit.hr	PROPN
hjic-1161	23	48	46	46	NUM
hjic-1161	23	49	milčić	milčić	PROPN
hjic-1161	23	50	,	,	PUNCT
hjic-1161	23	51	ćevid	ćevid	PROPN
hjic-1161	23	52	,	,	PUNCT
hjic-1161	23	53	çakar	çakar	NOUN
hjic-1161	23	54	,	,	PUNCT
hjic-1161	23	55	sudar	sudar	ADJ
hjic-1161	23	56	and	and	CCONJ
hjic-1161	23	57	findrik	findrik	VERB
hjic-1161	23	58	blažević	blažević	PROPN
hjic-1161	23	59	scheme	scheme	NOUN
hjic-1161	23	60	1	1	NUM
hjic-1161	23	61	:	:	PUNCT
hjic-1161	23	62	synthesis	synthesis	NOUN
hjic-1161	23	63	of	of	ADP
hjic-1161	23	64	(	(	PUNCT
hjic-1161	23	65	r)-γ	r)-γ	NOUN
hjic-1161	23	66	-	-	PUNCT
hjic-1161	23	67	chloro	chloro	NOUN
hjic-1161	23	68	-	-	PUNCT
hjic-1161	23	69	β	β	NOUN
hjic-1161	23	70	-	-	NOUN
hjic-1161	23	71	hydroxybutyronitrile	hydroxybutyronitrile	NOUN
hjic-1161	23	72	from	from	ADP
hjic-1161	23	73	an	an	DET
hjic-1161	23	74	achiral	achiral	ADJ
hjic-1161	23	75	substrate	substrate	NOUN
hjic-1161	23	76	scheme	scheme	NOUN
hjic-1161	23	77	2	2	NUM
hjic-1161	23	78	:	:	PUNCT
hjic-1161	23	79	synthesis	synthesis	NOUN
hjic-1161	23	80	of	of	ADP
hjic-1161	23	81	l	l	NOUN
hjic-1161	23	82	-	-	NOUN
hjic-1161	23	83	homoserine	homoserine	NOUN
hjic-1161	23	84	in	in	ADP
hjic-1161	23	85	a	a	DET
hjic-1161	23	86	cascade	cascade	NOUN
hjic-1161	23	87	reaction	reaction	NOUN
hjic-1161	23	88	sponding	sponde	VERB
hjic-1161	23	89	nucleophiles	nucleophile	NOUN
hjic-1161	23	90	can	can	AUX
hjic-1161	23	91	inhibit	inhibit	VERB
hjic-1161	23	92	the	the	DET
hjic-1161	23	93	catalytic	catalytic	ADJ
hjic-1161	23	94	activity	activity	NOUN
hjic-1161	23	95	of	of	ADP
hjic-1161	23	96	an	an	DET
hjic-1161	23	97	enzyme	enzyme	NOUN
hjic-1161	23	98	[	[	NOUN
hjic-1161	23	99	11	11	NUM
hjic-1161	23	100	]	]	PUNCT
hjic-1161	23	101	,	,	PUNCT
hjic-1161	23	102	the	the	DET
hjic-1161	23	103	selection	selection	NOUN
hjic-1161	23	104	of	of	ADP
hjic-1161	23	105	their	their	PRON
hjic-1161	23	106	concentrations	concentration	NOUN
hjic-1161	23	107	in	in	ADP
hjic-1161	23	108	the	the	DET
hjic-1161	23	109	reactor	reactor	NOUN
hjic-1161	23	110	is	be	AUX
hjic-1161	23	111	crucial	crucial	ADJ
hjic-1161	23	112	in	in	ADP
hjic-1161	23	113	facilitating	facilitate	VERB
hjic-1161	23	114	a	a	DET
hjic-1161	23	115	successful	successful	ADJ
hjic-1161	23	116	reaction	reaction	NOUN
hjic-1161	23	117	[	[	X
hjic-1161	23	118	12	12	NUM
hjic-1161	23	119	]	]	PUNCT
hjic-1161	23	120	.	.	PUNCT
hjic-1161	24	1	clearly	clearly	ADV
hjic-1161	24	2	,	,	PUNCT
hjic-1161	24	3	these	these	PRON
hjic-1161	24	4	are	be	AUX
hjic-1161	24	5	very	very	ADV
hjic-1161	24	6	complex	complex	ADJ
hjic-1161	24	7	reaction	reaction	NOUN
hjic-1161	24	8	systems	system	NOUN
hjic-1161	24	9	and	and	CCONJ
hjic-1161	24	10	the	the	DET
hjic-1161	24	11	suitable	suitable	ADJ
hjic-1161	24	12	set	set	NOUN
hjic-1161	24	13	up	up	ADP
hjic-1161	24	14	of	of	ADP
hjic-1161	24	15	a	a	DET
hjic-1161	24	16	reactor	reactor	NOUN
hjic-1161	24	17	as	as	ADV
hjic-1161	24	18	well	well	ADV
hjic-1161	24	19	as	as	ADP
hjic-1161	24	20	reaction	reaction	NOUN
hjic-1161	24	21	conditions	condition	NOUN
hjic-1161	24	22	determined	determine	VERB
hjic-1161	24	23	by	by	ADP
hjic-1161	24	24	the	the	DET
hjic-1161	24	25	model	model	NOUN
hjic-1161	24	26	-	-	PUNCT
hjic-1161	24	27	aided	aid	VERB
hjic-1161	24	28	approach	approach	NOUN
hjic-1161	24	29	can	can	AUX
hjic-1161	24	30	be	be	AUX
hjic-1161	24	31	vital	vital	ADJ
hjic-1161	24	32	[	[	X
hjic-1161	24	33	13	13	NUM
hjic-1161	24	34	]	]	PUNCT
hjic-1161	24	35	.	.	PUNCT
hjic-1161	25	1	multi	multi	ADJ
hjic-1161	25	2	-	-	ADJ
hjic-1161	25	3	step	step	ADJ
hjic-1161	25	4	reactions	reaction	NOUN
hjic-1161	25	5	can	can	AUX
hjic-1161	25	6	not	not	PART
hjic-1161	25	7	always	always	ADV
hjic-1161	25	8	be	be	AUX
hjic-1161	25	9	performed	perform	VERB
hjic-1161	25	10	simultaneously	simultaneously	ADV
hjic-1161	25	11	in	in	ADP
hjic-1161	25	12	one	one	NUM
hjic-1161	25	13	pot	pot	NOUN
hjic-1161	25	14	due	due	ADP
hjic-1161	25	15	to	to	ADP
hjic-1161	25	16	complex	complex	ADJ
hjic-1161	25	17	relationships	relationship	NOUN
hjic-1161	25	18	between	between	ADP
hjic-1161	25	19	the	the	DET
hjic-1161	25	20	process	process	NOUN
hjic-1161	25	21	variables	variable	VERB
hjic-1161	25	22	[	[	X
hjic-1161	25	23	14	14	NUM
hjic-1161	25	24	,	,	PUNCT
hjic-1161	25	25	18	18	NUM
hjic-1161	25	26	]	]	PUNCT
hjic-1161	25	27	.	.	PUNCT
hjic-1161	26	1	in	in	ADP
hjic-1161	26	2	a	a	DET
hjic-1161	26	3	study	study	NOUN
hjic-1161	26	4	of	of	ADP
hjic-1161	26	5	an	an	DET
hjic-1161	26	6	innovative	innovative	ADJ
hjic-1161	26	7	reaction	reaction	NOUN
hjic-1161	26	8	scheme	scheme	NOUN
hjic-1161	26	9	for	for	ADP
hjic-1161	26	10	the	the	DET
hjic-1161	26	11	preparation	preparation	NOUN
hjic-1161	26	12	of	of	ADP
hjic-1161	26	13	the	the	DET
hjic-1161	26	14	atorvastatin	atorvastatin	PROPN
hjic-1161	26	15	side	side	NOUN
hjic-1161	26	16	-	-	PUNCT
hjic-1161	26	17	chain	chain	NOUN
hjic-1161	26	18	precursor	precursor	NOUN
hjic-1161	26	19	,	,	PUNCT
hjic-1161	26	20	it	it	PRON
hjic-1161	26	21	was	be	AUX
hjic-1161	26	22	found	find	VERB
hjic-1161	26	23	that	that	SCONJ
hjic-1161	26	24	the	the	DET
hjic-1161	26	25	two	two	NUM
hjic-1161	26	26	reaction	reaction	NOUN
hjic-1161	26	27	steps	step	NOUN
hjic-1161	26	28	consisting	consist	VERB
hjic-1161	26	29	of	of	ADP
hjic-1161	26	30	aldol	aldol	NOUN
hjic-1161	26	31	addition	addition	NOUN
hjic-1161	26	32	and	and	CCONJ
hjic-1161	26	33	the	the	DET
hjic-1161	26	34	oxidation	oxidation	NOUN
hjic-1161	26	35	of	of	ADP
hjic-1161	26	36	the	the	DET
hjic-1161	26	37	corresponding	correspond	VERB
hjic-1161	26	38	product	product	NOUN
hjic-1161	26	39	amino	amino	NOUN
hjic-1161	26	40	lactol	lactol	ADJ
hjic-1161	26	41	could	could	AUX
hjic-1161	26	42	not	not	PART
hjic-1161	26	43	be	be	AUX
hjic-1161	26	44	performed	perform	VERB
hjic-1161	26	45	simultaneously	simultaneously	ADV
hjic-1161	26	46	[	[	X
hjic-1161	26	47	14	14	NUM
hjic-1161	26	48	]	]	PUNCT
hjic-1161	26	49	.	.	PUNCT
hjic-1161	27	1	this	this	PRON
hjic-1161	27	2	was	be	AUX
hjic-1161	27	3	mostly	mostly	ADV
hjic-1161	27	4	due	due	ADJ
hjic-1161	27	5	to	to	ADP
hjic-1161	27	6	the	the	DET
hjic-1161	27	7	fact	fact	NOUN
hjic-1161	27	8	that	that	SCONJ
hjic-1161	27	9	acetaldehyde	acetaldehyde	NOUN
hjic-1161	27	10	as	as	ADP
hjic-1161	27	11	the	the	DET
hjic-1161	27	12	substrate	substrate	NOUN
hjic-1161	27	13	in	in	ADP
hjic-1161	27	14	the	the	DET
hjic-1161	27	15	first	first	ADJ
hjic-1161	27	16	reaction	reaction	NOUN
hjic-1161	27	17	step	step	NOUN
hjic-1161	27	18	interferes	interfere	VERB
hjic-1161	27	19	with	with	ADP
hjic-1161	27	20	the	the	DET
hjic-1161	27	21	oxidoreduction	oxidoreduction	NOUN
hjic-1161	27	22	and	and	CCONJ
hjic-1161	27	23	coenzyme	coenzyme	NOUN
hjic-1161	27	24	regeneration	regeneration	NOUN
hjic-1161	27	25	by	by	ADP
hjic-1161	27	26	acting	act	VERB
hjic-1161	27	27	as	as	ADP
hjic-1161	27	28	a	a	DET
hjic-1161	27	29	substrate	substrate	NOUN
hjic-1161	27	30	for	for	ADP
hjic-1161	27	31	the	the	DET
hjic-1161	27	32	oxidoreductase	oxidoreductase	NOUN
hjic-1161	27	33	or	or	CCONJ
hjic-1161	27	34	as	as	ADP
hjic-1161	27	35	an	an	DET
hjic-1161	27	36	inhibitor	inhibitor	NOUN
hjic-1161	27	37	as	as	ADV
hjic-1161	27	38	well	well	ADV
hjic-1161	27	39	as	as	ADP
hjic-1161	27	40	deactivator	deactivator	NOUN
hjic-1161	27	41	of	of	ADP
hjic-1161	27	42	both	both	CCONJ
hjic-1161	27	43	oxidoreductase	oxidoreductase	ADJ
hjic-1161	27	44	and	and	CCONJ
hjic-1161	27	45	nadh	nadh	NOUN
hjic-1161	27	46	oxidase	oxidase	NOUN
hjic-1161	27	47	.	.	PUNCT
hjic-1161	28	1	it	it	PRON
hjic-1161	28	2	is	be	AUX
hjic-1161	28	3	important	important	ADJ
hjic-1161	28	4	to	to	PART
hjic-1161	28	5	determine	determine	VERB
hjic-1161	28	6	if	if	SCONJ
hjic-1161	28	7	all	all	DET
hjic-1161	28	8	the	the	DET
hjic-1161	28	9	reaction	reaction	NOUN
hjic-1161	28	10	steps	step	NOUN
hjic-1161	28	11	are	be	AUX
hjic-1161	28	12	compatible	compatible	ADJ
hjic-1161	28	13	with	with	ADP
hjic-1161	28	14	each	each	DET
hjic-1161	28	15	other	other	ADJ
hjic-1161	28	16	before	before	ADP
hjic-1161	28	17	deciding	decide	VERB
hjic-1161	28	18	how	how	SCONJ
hjic-1161	28	19	to	to	PART
hjic-1161	28	20	develop	develop	VERB
hjic-1161	28	21	the	the	DET
hjic-1161	28	22	reaction	reaction	NOUN
hjic-1161	28	23	.	.	PUNCT
hjic-1161	29	1	although	although	SCONJ
hjic-1161	29	2	this	this	PRON
hjic-1161	29	3	might	might	AUX
hjic-1161	29	4	suggest	suggest	VERB
hjic-1161	29	5	a	a	DET
hjic-1161	29	6	significant	significant	ADJ
hjic-1161	29	7	amount	amount	NOUN
hjic-1161	29	8	of	of	ADP
hjic-1161	29	9	experimental	experimental	ADJ
hjic-1161	29	10	work	work	NOUN
hjic-1161	29	11	,	,	PUNCT
hjic-1161	29	12	this	this	PRON
hjic-1161	29	13	can	can	AUX
hjic-1161	29	14	be	be	AUX
hjic-1161	29	15	considerably	considerably	ADV
hjic-1161	29	16	reduced	reduce	VERB
hjic-1161	29	17	by	by	ADP
hjic-1161	29	18	evaluating	evaluate	VERB
hjic-1161	29	19	the	the	DET
hjic-1161	29	20	enzyme	enzyme	NOUN
hjic-1161	29	21	kinetics	kinetic	NOUN
hjic-1161	29	22	[	[	X
hjic-1161	29	23	13	13	NUM
hjic-1161	29	24	,	,	PUNCT
hjic-1161	29	25	19	19	NUM
hjic-1161	29	26	,	,	PUNCT
hjic-1161	29	27	20	20	NUM
hjic-1161	29	28	]	]	PUNCT
hjic-1161	29	29	.	.	PUNCT
hjic-1161	30	1	forming	form	VERB
hjic-1161	30	2	the	the	DET
hjic-1161	30	3	reaction	reaction	NOUN
hjic-1161	30	4	model	model	NOUN
hjic-1161	30	5	enables	enable	VERB
hjic-1161	30	6	a	a	DET
hjic-1161	30	7	vast	vast	ADJ
hjic-1161	30	8	variable	variable	ADJ
hjic-1161	30	9	space	space	NOUN
hjic-1161	30	10	to	to	PART
hjic-1161	30	11	be	be	AUX
hjic-1161	30	12	explored	explore	VERB
hjic-1161	30	13	in	in	ADP
hjic-1161	30	14	silico	silico	NOUN
hjic-1161	30	15	.	.	PUNCT
hjic-1161	31	1	apart	apart	ADV
hjic-1161	31	2	from	from	ADP
hjic-1161	31	3	that	that	PRON
hjic-1161	31	4	,	,	PUNCT
hjic-1161	31	5	combining	combine	VERB
hjic-1161	31	6	the	the	DET
hjic-1161	31	7	kinetic	kinetic	ADJ
hjic-1161	31	8	model	model	NOUN
hjic-1161	31	9	with	with	ADP
hjic-1161	31	10	mass	mass	ADJ
hjic-1161	31	11	balances	balance	NOUN
hjic-1161	31	12	in	in	ADP
hjic-1161	31	13	different	different	ADJ
hjic-1161	31	14	reactors	reactor	NOUN
hjic-1161	31	15	enables	enable	VERB
hjic-1161	31	16	different	different	ADJ
hjic-1161	31	17	types	type	NOUN
hjic-1161	31	18	of	of	ADP
hjic-1161	31	19	reactors	reactor	NOUN
hjic-1161	31	20	to	to	PART
hjic-1161	31	21	be	be	AUX
hjic-1161	31	22	explored	explore	VERB
hjic-1161	31	23	in	in	ADP
hjic-1161	31	24	each	each	DET
hjic-1161	31	25	system	system	NOUN
hjic-1161	31	26	.	.	PUNCT
hjic-1161	32	1	this	this	PRON
hjic-1161	32	2	was	be	AUX
hjic-1161	32	3	found	find	VERB
hjic-1161	32	4	to	to	PART
hjic-1161	32	5	be	be	AUX
hjic-1161	32	6	crucial	crucial	ADJ
hjic-1161	32	7	with	with	ADP
hjic-1161	32	8	regard	regard	NOUN
hjic-1161	32	9	to	to	ADP
hjic-1161	32	10	improving	improve	VERB
hjic-1161	32	11	the	the	DET
hjic-1161	32	12	process	process	NOUN
hjic-1161	32	13	metrics	metric	NOUN
hjic-1161	32	14	in	in	ADP
hjic-1161	32	15	the	the	DET
hjic-1161	32	16	synthesis	synthesis	NOUN
hjic-1161	32	17	of	of	ADP
hjic-1161	32	18	lhomoserine	lhomoserine	NOUN
hjic-1161	32	19	[	[	X
hjic-1161	32	20	21	21	NUM
hjic-1161	32	21	]	]	X
hjic-1161	32	22	,	,	PUNCT
hjic-1161	32	23	a	a	DET
hjic-1161	32	24	system	system	NOUN
hjic-1161	32	25	governed	govern	VERB
hjic-1161	32	26	by	by	ADP
hjic-1161	32	27	the	the	DET
hjic-1161	32	28	unfavourable	unfavourable	ADJ
hjic-1161	32	29	equilibrium	equilibrium	NOUN
hjic-1161	32	30	of	of	ADP
hjic-1161	32	31	the	the	DET
hjic-1161	32	32	transaminase	transaminase	NOUN
hjic-1161	32	33	-	-	PUNCT
hjic-1161	32	34	catalysed	catalyse	VERB
hjic-1161	32	35	reaction	reaction	NOUN
hjic-1161	32	36	and	and	CCONJ
hjic-1161	32	37	aided	aid	VERB
hjic-1161	32	38	by	by	ADP
hjic-1161	32	39	the	the	DET
hjic-1161	32	40	pyruvate	pyruvate	NOUN
hjic-1161	32	41	recycling	recycling	NOUN
hjic-1161	32	42	system	system	NOUN
hjic-1161	32	43	catalysed	catalyse	VERB
hjic-1161	32	44	by	by	ADP
hjic-1161	32	45	aldolase	aldolase	NOUN
hjic-1161	32	46	(	(	PUNCT
hjic-1161	32	47	scheme	scheme	NOUN
hjic-1161	32	48	2	2	NUM
hjic-1161	32	49	)	)	PUNCT
hjic-1161	32	50	.	.	PUNCT
hjic-1161	33	1	the	the	DET
hjic-1161	33	2	application	application	NOUN
hjic-1161	33	3	of	of	ADP
hjic-1161	33	4	model	model	NOUN
hjic-1161	33	5	-	-	PUNCT
hjic-1161	33	6	based	base	VERB
hjic-1161	33	7	optimization	optimization	NOUN
hjic-1161	33	8	techniques	technique	NOUN
hjic-1161	33	9	led	lead	VERB
hjic-1161	33	10	to	to	ADP
hjic-1161	33	11	a	a	DET
hjic-1161	33	12	doubling	doubling	NOUN
hjic-1161	33	13	of	of	ADP
hjic-1161	33	14	the	the	DET
hjic-1161	33	15	product	product	NOUN
hjic-1161	33	16	concentration	concentration	NOUN
hjic-1161	33	17	(	(	PUNCT
hjic-1161	33	18	up	up	ADP
hjic-1161	33	19	to	to	PART
hjic-1161	33	20	80	80	NUM
hjic-1161	33	21	gl−1	gl−1	NOUN
hjic-1161	33	22	)	)	PUNCT
hjic-1161	33	23	and	and	CCONJ
hjic-1161	33	24	an	an	DET
hjic-1161	33	25	18	18	NUM
hjic-1161	33	26	%	%	NOUN
hjic-1161	33	27	increase	increase	NOUN
hjic-1161	33	28	in	in	ADP
hjic-1161	33	29	the	the	DET
hjic-1161	33	30	volumetric	volumetric	NOUN
hjic-1161	33	31	productivity	productivity	NOUN
hjic-1161	33	32	(	(	PUNCT
hjic-1161	33	33	up	up	ADP
hjic-1161	33	34	to	to	PART
hjic-1161	33	35	3.2	3.2	NUM
hjic-1161	33	36	gl−1h−1	gl−1h−1	NOUN
hjic-1161	33	37	)	)	PUNCT
hjic-1161	33	38	in	in	ADP
hjic-1161	33	39	comparison	comparison	NOUN
hjic-1161	33	40	with	with	ADP
hjic-1161	33	41	a	a	DET
hjic-1161	33	42	previously	previously	ADV
hjic-1161	33	43	published	publish	VERB
hjic-1161	33	44	work	work	NOUN
hjic-1161	33	45	[	[	X
hjic-1161	33	46	22	22	NUM
hjic-1161	33	47	]	]	PUNCT
hjic-1161	33	48	.	.	PUNCT
hjic-1161	34	1	in	in	ADP
hjic-1161	34	2	this	this	DET
hjic-1161	34	3	system	system	NOUN
hjic-1161	34	4	,	,	PUNCT
hjic-1161	34	5	it	it	PRON
hjic-1161	34	6	was	be	AUX
hjic-1161	34	7	crucial	crucial	ADJ
hjic-1161	34	8	that	that	SCONJ
hjic-1161	34	9	both	both	DET
hjic-1161	34	10	reactions	reaction	NOUN
hjic-1161	34	11	were	be	AUX
hjic-1161	34	12	carried	carry	VERB
hjic-1161	34	13	out	out	ADP
hjic-1161	34	14	simultaneously	simultaneously	ADV
hjic-1161	34	15	to	to	PART
hjic-1161	34	16	improve	improve	VERB
hjic-1161	34	17	the	the	DET
hjic-1161	34	18	position	position	NOUN
hjic-1161	34	19	of	of	ADP
hjic-1161	34	20	the	the	DET
hjic-1161	34	21	equilibrium	equilibrium	NOUN
hjic-1161	34	22	.	.	PUNCT
hjic-1161	35	1	formaldehyde	formaldehyde	NOUN
hjic-1161	35	2	was	be	AUX
hjic-1161	35	3	gradually	gradually	ADV
hjic-1161	35	4	added	add	VERB
hjic-1161	35	5	to	to	ADP
hjic-1161	35	6	the	the	DET
hjic-1161	35	7	system	system	NOUN
hjic-1161	35	8	by	by	ADP
hjic-1161	35	9	using	use	VERB
hjic-1161	35	10	a	a	DET
hjic-1161	35	11	pump	pump	NOUN
hjic-1161	35	12	due	due	ADP
hjic-1161	35	13	to	to	ADP
hjic-1161	35	14	its	its	PRON
hjic-1161	35	15	reactivity	reactivity	NOUN
hjic-1161	35	16	and	and	CCONJ
hjic-1161	35	17	inhibiting	inhibit	VERB
hjic-1161	35	18	effect	effect	NOUN
hjic-1161	35	19	on	on	ADP
hjic-1161	35	20	enzyme	enzyme	NOUN
hjic-1161	35	21	activity	activity	NOUN
hjic-1161	35	22	.	.	PUNCT
hjic-1161	36	1	additionally	additionally	ADV
hjic-1161	36	2	,	,	PUNCT
hjic-1161	36	3	pyruvate	pyruvate	NOUN
hjic-1161	36	4	and	and	CCONJ
hjic-1161	36	5	l	l	NOUN
hjic-1161	36	6	-	-	NOUN
hjic-1161	36	7	alanine	alanine	NOUN
hjic-1161	36	8	were	be	AUX
hjic-1161	36	9	added	add	VERB
hjic-1161	36	10	sequentially	sequentially	ADV
hjic-1161	36	11	once	once	SCONJ
hjic-1161	36	12	the	the	DET
hjic-1161	36	13	pyruvate	pyruvate	NOUN
hjic-1161	36	14	had	have	AUX
hjic-1161	36	15	been	be	AUX
hjic-1161	36	16	consumed	consume	VERB
hjic-1161	36	17	in	in	ADP
hjic-1161	36	18	several	several	ADJ
hjic-1161	36	19	doses	dose	NOUN
hjic-1161	36	20	,	,	PUNCT
hjic-1161	36	21	which	which	PRON
hjic-1161	36	22	,	,	PUNCT
hjic-1161	36	23	according	accord	VERB
hjic-1161	36	24	to	to	ADP
hjic-1161	36	25	calculations	calculation	NOUN
hjic-1161	36	26	,	,	PUNCT
hjic-1161	36	27	was	be	AUX
hjic-1161	36	28	found	find	VERB
hjic-1161	36	29	to	to	PART
hjic-1161	36	30	work	work	VERB
hjic-1161	36	31	in	in	ADP
hjic-1161	36	32	silico	silico	NOUN
hjic-1161	36	33	experiments	experiment	NOUN
hjic-1161	36	34	(	(	PUNCT
hjic-1161	36	35	fig	fig	NOUN
hjic-1161	36	36	.	.	PUNCT
hjic-1161	37	1	1	1	NUM
hjic-1161	37	2	a	a	DET
hjic-1161	37	3	-	-	PUNCT
hjic-1161	37	4	b	b	NOUN
hjic-1161	37	5	)	)	PUNCT
hjic-1161	37	6	and	and	CCONJ
hjic-1161	37	7	subsequently	subsequently	ADV
hjic-1161	37	8	proved	prove	VERB
hjic-1161	37	9	experimentally	experimentally	ADV
hjic-1161	37	10	(	(	PUNCT
hjic-1161	37	11	fig	fig	NOUN
hjic-1161	37	12	.	.	NOUN
hjic-1161	38	1	1	1	NUM
hjic-1161	38	2	c	c	X
hjic-1161	38	3	-	-	PUNCT
hjic-1161	38	4	d	d	NOUN
hjic-1161	38	5	)	)	PUNCT
hjic-1161	38	6	.	.	PUNCT
hjic-1161	39	1	2	2	X
hjic-1161	39	2	.	.	X
hjic-1161	39	3	side	side	NOUN
hjic-1161	39	4	reactions	reaction	NOUN
hjic-1161	39	5	and	and	CCONJ
hjic-1161	39	6	their	their	PRON
hjic-1161	39	7	effect	effect	NOUN
hjic-1161	39	8	on	on	ADP
hjic-1161	39	9	the	the	DET
hjic-1161	39	10	reaction	reaction	NOUN
hjic-1161	39	11	scheme	scheme	NOUN
hjic-1161	39	12	.	.	PUNCT
hjic-1161	40	1	when	when	SCONJ
hjic-1161	40	2	studying	study	VERB
hjic-1161	40	3	a	a	DET
hjic-1161	40	4	complex	complex	ADJ
hjic-1161	40	5	reaction	reaction	NOUN
hjic-1161	40	6	system	system	NOUN
hjic-1161	40	7	,	,	PUNCT
hjic-1161	40	8	possible	possible	ADJ
hjic-1161	40	9	side	side	NOUN
hjic-1161	40	10	reactions	reaction	NOUN
hjic-1161	40	11	must	must	AUX
hjic-1161	40	12	be	be	AUX
hjic-1161	40	13	taken	take	VERB
hjic-1161	40	14	into	into	ADP
hjic-1161	40	15	account	account	NOUN
hjic-1161	40	16	.	.	PUNCT
hjic-1161	41	1	these	these	PRON
hjic-1161	41	2	can	can	AUX
hjic-1161	41	3	be	be	AUX
hjic-1161	41	4	caused	cause	VERB
hjic-1161	41	5	by	by	ADP
hjic-1161	41	6	the	the	DET
hjic-1161	41	7	instability	instability	NOUN
hjic-1161	41	8	of	of	ADP
hjic-1161	41	9	reactants	reactant	NOUN
hjic-1161	41	10	,	,	PUNCT
hjic-1161	41	11	products	product	NOUN
hjic-1161	41	12	or	or	CCONJ
hjic-1161	41	13	intermediates	intermediate	NOUN
hjic-1161	41	14	;	;	PUNCT
hjic-1161	41	15	by	by	ADP
hjic-1161	41	16	chemical	chemical	ADJ
hjic-1161	41	17	reactions	reaction	NOUN
hjic-1161	41	18	between	between	ADP
hjic-1161	41	19	the	the	DET
hjic-1161	41	20	compounds	compound	NOUN
hjic-1161	41	21	present	present	ADJ
hjic-1161	41	22	in	in	ADP
hjic-1161	41	23	the	the	DET
hjic-1161	41	24	reaction	reaction	NOUN
hjic-1161	41	25	mixture	mixture	NOUN
hjic-1161	41	26	;	;	PUNCT
hjic-1161	41	27	as	as	ADV
hjic-1161	41	28	well	well	ADV
hjic-1161	41	29	as	as	ADP
hjic-1161	41	30	by	by	ADP
hjic-1161	41	31	the	the	DET
hjic-1161	41	32	side	side	NOUN
hjic-1161	41	33	reactions	reaction	NOUN
hjic-1161	41	34	hungarian	hungarian	ADJ
hjic-1161	41	35	journal	journal	NOUN
hjic-1161	41	36	of	of	ADP
hjic-1161	41	37	industry	industry	NOUN
hjic-1161	41	38	and	and	CCONJ
hjic-1161	41	39	chemistry	chemistry	NOUN
hjic-1161	41	40	enzyme	enzyme	NOUN
hjic-1161	41	41	reaction	reaction	NOUN
hjic-1161	41	42	engineering	engineering	NOUN
hjic-1161	41	43	as	as	ADP
hjic-1161	41	44	a	a	DET
hjic-1161	41	45	tool	tool	NOUN
hjic-1161	41	46	47	47	NUM
hjic-1161	41	47	(	(	PUNCT
hjic-1161	41	48	a	a	NOUN
hjic-1161	41	49	)	)	PUNCT
hjic-1161	41	50	(	(	PUNCT
hjic-1161	41	51	b	b	X
hjic-1161	41	52	)	)	PUNCT
hjic-1161	41	53	(	(	PUNCT
hjic-1161	41	54	c	c	X
hjic-1161	41	55	)	)	PUNCT
hjic-1161	41	56	(	(	PUNCT
hjic-1161	41	57	d	d	X
hjic-1161	41	58	)	)	PUNCT
hjic-1161	41	59	figure	figure	NOUN
hjic-1161	41	60	1	1	NUM
hjic-1161	41	61	:	:	PUNCT
hjic-1161	41	62	cascade	cascade	NOUN
hjic-1161	41	63	synthesis	synthesis	NOUN
hjic-1161	41	64	of	of	ADP
hjic-1161	41	65	l	l	NOUN
hjic-1161	41	66	-	-	NOUN
hjic-1161	41	67	homoserine	homoserine	NOUN
hjic-1161	42	1	[	[	X
hjic-1161	42	2	20	20	NUM
hjic-1161	42	3	]	]	PUNCT
hjic-1161	42	4	in	in	ADP
hjic-1161	42	5	a	a	DET
hjic-1161	42	6	fed	feed	VERB
hjic-1161	42	7	-	-	PUNCT
hjic-1161	42	8	batch	batch	NOUN
hjic-1161	42	9	bioreactor	bioreactor	NOUN
hjic-1161	42	10	by	by	ADP
hjic-1161	42	11	gradually	gradually	ADV
hjic-1161	42	12	adding	add	VERB
hjic-1161	42	13	formaldehyde	formaldehyde	NOUN
hjic-1161	42	14	via	via	ADP
hjic-1161	42	15	a	a	DET
hjic-1161	42	16	pump	pump	NOUN
hjic-1161	42	17	as	as	ADV
hjic-1161	42	18	well	well	ADV
hjic-1161	42	19	as	as	ADP
hjic-1161	42	20	sequentially	sequentially	ADV
hjic-1161	42	21	adding	add	VERB
hjic-1161	42	22	pyruvate	pyruvate	NOUN
hjic-1161	42	23	and	and	CCONJ
hjic-1161	42	24	l	l	NOUN
hjic-1161	42	25	-	-	NOUN
hjic-1161	42	26	alanine	alanine	NOUN
hjic-1161	42	27	incrementally	incrementally	ADV
hjic-1161	42	28	once	once	SCONJ
hjic-1161	42	29	the	the	DET
hjic-1161	42	30	pyruvate	pyruvate	NOUN
hjic-1161	42	31	had	have	AUX
hjic-1161	42	32	been	be	AUX
hjic-1161	42	33	consumed	consume	VERB
hjic-1161	42	34	.	.	PUNCT
hjic-1161	43	1	(	(	PUNCT
hjic-1161	43	2	a	a	X
hjic-1161	43	3	)	)	PUNCT
hjic-1161	43	4	(	(	PUNCT
hjic-1161	43	5	black	black	ADJ
hjic-1161	43	6	line	line	NOUN
hjic-1161	43	7	–	–	PUNCT
hjic-1161	43	8	l	l	NOUN
hjic-1161	43	9	-	-	NOUN
hjic-1161	43	10	alanine	alanine	NOUN
hjic-1161	43	11	,	,	PUNCT
hjic-1161	43	12	dashed	dash	VERB
hjic-1161	43	13	line	line	NOUN
hjic-1161	43	14	–	–	PUNCT
hjic-1161	43	15	pyruvate	pyruvate	NOUN
hjic-1161	43	16	,	,	PUNCT
hjic-1161	43	17	dotted	dotted	ADJ
hjic-1161	43	18	line	line	NOUN
hjic-1161	43	19	–	–	PUNCT
hjic-1161	43	20	formaldehyde	formaldehyde	NOUN
hjic-1161	43	21	)	)	PUNCT
hjic-1161	43	22	,	,	PUNCT
hjic-1161	43	23	(	(	PUNCT
hjic-1161	43	24	b	b	X
hjic-1161	43	25	)	)	PUNCT
hjic-1161	43	26	(	(	PUNCT
hjic-1161	43	27	grey	grey	NOUN
hjic-1161	43	28	line	line	NOUN
hjic-1161	43	29	–	–	PUNCT
hjic-1161	43	30	l	l	NOUN
hjic-1161	43	31	-	-	NOUN
hjic-1161	43	32	homoserine	homoserine	NOUN
hjic-1161	43	33	,	,	PUNCT
hjic-1161	43	34	grey	grey	PROPN
hjic-1161	43	35	dashed	dash	VERB
hjic-1161	43	36	line	line	NOUN
hjic-1161	43	37	–	–	PUNCT
hjic-1161	43	38	aldol	aldol	NOUN
hjic-1161	43	39	intermediate	intermediate	ADJ
hjic-1161	43	40	)	)	PUNCT
hjic-1161	43	41	.	.	PUNCT
hjic-1161	44	1	in	in	ADP
hjic-1161	44	2	silico	silico	NOUN
hjic-1161	44	3	experiments	experiment	NOUN
hjic-1161	44	4	,	,	PUNCT
hjic-1161	44	5	(	(	PUNCT
hjic-1161	44	6	c	c	X
hjic-1161	44	7	)	)	PUNCT
hjic-1161	44	8	experimental	experimental	ADJ
hjic-1161	44	9	validation	validation	NOUN
hjic-1161	44	10	(	(	PUNCT
hjic-1161	44	11	black	black	ADJ
hjic-1161	44	12	triangles	triangle	NOUN
hjic-1161	44	13	–	–	PUNCT
hjic-1161	44	14	l	l	NOUN
hjic-1161	44	15	-	-	NOUN
hjic-1161	44	16	alanine	alanine	NOUN
hjic-1161	44	17	,	,	PUNCT
hjic-1161	44	18	white	white	ADJ
hjic-1161	44	19	squares	square	NOUN
hjic-1161	44	20	–	–	PUNCT
hjic-1161	44	21	pyruvate	pyruvate	NOUN
hjic-1161	44	22	,	,	PUNCT
hjic-1161	44	23	blue	blue	ADJ
hjic-1161	44	24	diamonds	diamond	NOUN
hjic-1161	44	25	–	–	PUNCT
hjic-1161	44	26	formaldehyde	formaldehyde	NOUN
hjic-1161	44	27	)	)	PUNCT
hjic-1161	44	28	,	,	PUNCT
hjic-1161	44	29	and	and	CCONJ
hjic-1161	44	30	(	(	PUNCT
hjic-1161	44	31	d	d	X
hjic-1161	44	32	)	)	PUNCT
hjic-1161	44	33	experimental	experimental	ADJ
hjic-1161	44	34	validation	validation	NOUN
hjic-1161	44	35	(	(	PUNCT
hjic-1161	44	36	red	red	ADJ
hjic-1161	44	37	circles	circle	NOUN
hjic-1161	44	38	–	–	PUNCT
hjic-1161	44	39	l	l	NOUN
hjic-1161	44	40	-	-	NOUN
hjic-1161	44	41	homoserine	homoserine	NOUN
hjic-1161	44	42	,	,	PUNCT
hjic-1161	44	43	grey	grey	ADJ
hjic-1161	44	44	stars	star	NOUN
hjic-1161	44	45	–	–	PUNCT
hjic-1161	44	46	aldol	aldol	NOUN
hjic-1161	44	47	intermediate	intermediate	ADJ
hjic-1161	44	48	)	)	PUNCT
hjic-1161	44	49	.	.	PUNCT
hjic-1161	45	1	scheme	scheme	NOUN
hjic-1161	45	2	3	3	NUM
hjic-1161	45	3	:	:	PUNCT
hjic-1161	45	4	synthesis	synthesis	NOUN
hjic-1161	45	5	of	of	ADP
hjic-1161	45	6	the	the	DET
hjic-1161	45	7	aldol	aldol	NOUN
hjic-1161	45	8	product	product	NOUN
hjic-1161	45	9	(	(	PUNCT
hjic-1161	45	10	3s,4r)-6-[(benzyloxycarbonyl)amino]-5,6	3s,4r)-6-[(benzyloxycarbonyl)amino]-5,6	NUM
hjic-1161	45	11	-	-	PUNCT
hjic-1161	45	12	dideoxyhex-2	dideoxyhex-2	VERB
hjic-1161	45	13	-	-	ADJ
hjic-1161	45	14	ulose	ulose	ADJ
hjic-1161	45	15	in	in	ADP
hjic-1161	45	16	a	a	DET
hjic-1161	45	17	cascade	cascade	NOUN
hjic-1161	45	18	reaction	reaction	NOUN
hjic-1161	45	19	50	50	NUM
hjic-1161	45	20	pp	pp	NOUN
hjic-1161	45	21	.	.	PUNCT
hjic-1161	46	1	45–55	45–55	NUM
hjic-1161	46	2	(	(	PUNCT
hjic-1161	46	3	2022	2022	NUM
hjic-1161	46	4	)	)	PUNCT
hjic-1161	46	5	48	48	NUM
hjic-1161	46	6	milčić	milčić	PROPN
hjic-1161	46	7	,	,	PUNCT
hjic-1161	46	8	ćevid	ćevid	PROPN
hjic-1161	46	9	,	,	PUNCT
hjic-1161	46	10	çakar	çakar	NOUN
hjic-1161	46	11	,	,	PUNCT
hjic-1161	46	12	sudar	sudar	ADJ
hjic-1161	46	13	and	and	CCONJ
hjic-1161	46	14	findrik	findrik	PROPN
hjic-1161	46	15	blažević	blažević	PROPN
hjic-1161	46	16	caused	cause	VERB
hjic-1161	46	17	by	by	ADP
hjic-1161	46	18	the	the	DET
hjic-1161	46	19	catalytic	catalytic	ADJ
hjic-1161	46	20	enzymes	enzyme	NOUN
hjic-1161	46	21	due	due	ADP
hjic-1161	46	22	to	to	ADP
hjic-1161	46	23	their	their	PRON
hjic-1161	46	24	low	low	ADJ
hjic-1161	46	25	purity	purity	NOUN
hjic-1161	46	26	or	or	CCONJ
hjic-1161	46	27	ability	ability	NOUN
hjic-1161	46	28	to	to	PART
hjic-1161	46	29	catalyse	catalyse	VERB
hjic-1161	46	30	more	more	ADJ
hjic-1161	46	31	than	than	ADP
hjic-1161	46	32	one	one	NUM
hjic-1161	46	33	reaction	reaction	NOUN
hjic-1161	46	34	[	[	X
hjic-1161	46	35	8	8	NUM
hjic-1161	46	36	,	,	PUNCT
hjic-1161	46	37	23	23	NUM
hjic-1161	46	38	,	,	PUNCT
hjic-1161	46	39	24	24	NUM
hjic-1161	46	40	]	]	PUNCT
hjic-1161	46	41	.	.	PUNCT
hjic-1161	47	1	reactions	reaction	NOUN
hjic-1161	47	2	are	be	AUX
hjic-1161	47	3	often	often	ADV
hjic-1161	47	4	carried	carry	VERB
hjic-1161	47	5	out	out	ADP
hjic-1161	47	6	with	with	ADP
hjic-1161	47	7	a	a	DET
hjic-1161	47	8	crude	crude	ADJ
hjic-1161	47	9	enzyme	enzyme	NOUN
hjic-1161	47	10	extract	extract	NOUN
hjic-1161	47	11	or	or	CCONJ
hjic-1161	47	12	whole	whole	ADJ
hjic-1161	47	13	cells	cell	NOUN
hjic-1161	47	14	in	in	ADP
hjic-1161	47	15	order	order	NOUN
hjic-1161	47	16	to	to	PART
hjic-1161	47	17	reduce	reduce	VERB
hjic-1161	47	18	the	the	DET
hjic-1161	47	19	costs	cost	NOUN
hjic-1161	47	20	of	of	ADP
hjic-1161	47	21	synthesising	synthesise	VERB
hjic-1161	47	22	the	the	DET
hjic-1161	47	23	protein	protein	NOUN
hjic-1161	47	24	by	by	ADP
hjic-1161	47	25	avoiding	avoid	VERB
hjic-1161	47	26	the	the	DET
hjic-1161	47	27	necessity	necessity	NOUN
hjic-1161	47	28	for	for	ADP
hjic-1161	47	29	purification	purification	NOUN
hjic-1161	47	30	.	.	PUNCT
hjic-1161	48	1	although	although	SCONJ
hjic-1161	48	2	such	such	ADJ
hjic-1161	48	3	systems	system	NOUN
hjic-1161	48	4	often	often	ADV
hjic-1161	48	5	offer	offer	VERB
hjic-1161	48	6	an	an	DET
hjic-1161	48	7	additional	additional	ADJ
hjic-1161	48	8	advantage	advantage	NOUN
hjic-1161	48	9	in	in	ADP
hjic-1161	48	10	terms	term	NOUN
hjic-1161	48	11	of	of	ADP
hjic-1161	48	12	enhancing	enhance	VERB
hjic-1161	48	13	the	the	DET
hjic-1161	48	14	operational	operational	ADJ
hjic-1161	48	15	stability	stability	NOUN
hjic-1161	48	16	of	of	ADP
hjic-1161	48	17	the	the	DET
hjic-1161	48	18	desired	desire	VERB
hjic-1161	48	19	enzyme	enzyme	NOUN
hjic-1161	48	20	within	within	ADP
hjic-1161	48	21	the	the	DET
hjic-1161	48	22	protein	protein	NOUN
hjic-1161	48	23	mixture	mixture	NOUN
hjic-1161	48	24	or	or	CCONJ
hjic-1161	48	25	cell	cell	NOUN
hjic-1161	48	26	compartment	compartment	NOUN
hjic-1161	48	27	,	,	PUNCT
hjic-1161	48	28	other	other	ADJ
hjic-1161	48	29	enzymes	enzyme	NOUN
hjic-1161	48	30	in	in	ADP
hjic-1161	48	31	these	these	DET
hjic-1161	48	32	systems	system	NOUN
hjic-1161	48	33	can	can	AUX
hjic-1161	48	34	also	also	ADV
hjic-1161	48	35	catalyse	catalyse	VERB
hjic-1161	48	36	undesirable	undesirable	ADJ
hjic-1161	48	37	enzymatic	enzymatic	ADJ
hjic-1161	48	38	reactions	reaction	NOUN
hjic-1161	48	39	[	[	X
hjic-1161	48	40	23	23	NUM
hjic-1161	48	41	]	]	PUNCT
hjic-1161	48	42	.	.	PUNCT
hjic-1161	49	1	all	all	PRON
hjic-1161	49	2	of	of	ADP
hjic-1161	49	3	these	these	DET
hjic-1161	49	4	aforementioned	aforementioned	ADJ
hjic-1161	49	5	reactions	reaction	NOUN
hjic-1161	49	6	can	can	AUX
hjic-1161	49	7	lower	lower	VERB
hjic-1161	49	8	the	the	DET
hjic-1161	49	9	concentration	concentration	NOUN
hjic-1161	49	10	of	of	ADP
hjic-1161	49	11	the	the	DET
hjic-1161	49	12	target	target	NOUN
hjic-1161	49	13	product	product	NOUN
hjic-1161	49	14	as	as	ADV
hjic-1161	49	15	well	well	ADV
hjic-1161	49	16	as	as	ADP
hjic-1161	49	17	decrease	decrease	VERB
hjic-1161	49	18	the	the	DET
hjic-1161	49	19	reaction	reaction	NOUN
hjic-1161	49	20	yield	yield	NOUN
hjic-1161	49	21	,	,	PUNCT
hjic-1161	49	22	moreover	moreover	ADV
hjic-1161	49	23	,	,	PUNCT
hjic-1161	49	24	in	in	ADP
hjic-1161	49	25	some	some	DET
hjic-1161	49	26	cases	case	NOUN
hjic-1161	49	27	,	,	PUNCT
hjic-1161	49	28	even	even	ADV
hjic-1161	49	29	prevent	prevent	VERB
hjic-1161	49	30	the	the	DET
hjic-1161	49	31	formation	formation	NOUN
hjic-1161	49	32	of	of	ADP
hjic-1161	49	33	the	the	DET
hjic-1161	49	34	target	target	NOUN
hjic-1161	49	35	product	product	NOUN
hjic-1161	49	36	.	.	PUNCT
hjic-1161	50	1	one	one	NUM
hjic-1161	50	2	example	example	NOUN
hjic-1161	50	3	of	of	ADP
hjic-1161	50	4	such	such	DET
hjic-1161	50	5	an	an	DET
hjic-1161	50	6	event	event	NOUN
hjic-1161	50	7	is	be	AUX
hjic-1161	50	8	the	the	DET
hjic-1161	50	9	oxidation	oxidation	NOUN
hjic-1161	50	10	of	of	ADP
hjic-1161	50	11	an	an	DET
hjic-1161	50	12	alcohol	alcohol	NOUN
hjic-1161	50	13	to	to	PART
hjic-1161	50	14	form	form	VERB
hjic-1161	50	15	an	an	DET
hjic-1161	50	16	aldehyde	aldehyde	NOUN
hjic-1161	50	17	catalysed	catalyse	VERB
hjic-1161	50	18	by	by	ADP
hjic-1161	50	19	horse	horse	NOUN
hjic-1161	50	20	liver	liver	NOUN
hjic-1161	50	21	alcohol	alcohol	NOUN
hjic-1161	50	22	dehydrogenase	dehydrogenase	NOUN
hjic-1161	50	23	that	that	PRON
hjic-1161	50	24	reacts	react	VERB
hjic-1161	50	25	further	far	ADV
hjic-1161	50	26	by	by	ADP
hjic-1161	50	27	oxidizing	oxidize	VERB
hjic-1161	50	28	the	the	DET
hjic-1161	50	29	aldehyde	aldehyde	NOUN
hjic-1161	50	30	to	to	PART
hjic-1161	50	31	form	form	VERB
hjic-1161	50	32	the	the	DET
hjic-1161	50	33	corresponding	correspond	VERB
hjic-1161	50	34	acid	acid	NOUN
hjic-1161	50	35	as	as	ADP
hjic-1161	50	36	a	a	DET
hjic-1161	50	37	side	side	NOUN
hjic-1161	50	38	product	product	NOUN
hjic-1161	50	39	.	.	PUNCT
hjic-1161	51	1	in	in	ADP
hjic-1161	51	2	the	the	DET
hjic-1161	51	3	cascade	cascade	NOUN
hjic-1161	51	4	synthesis	synthesis	NOUN
hjic-1161	51	5	of	of	ADP
hjic-1161	51	6	(	(	PUNCT
hjic-1161	51	7	3s,4r)-6[(benzyloxycarbonyl)amino]-5,6	3s,4r)-6[(benzyloxycarbonyl)amino]-5,6	PROPN
hjic-1161	51	8	-	-	PUNCT
hjic-1161	51	9	dideoxyhex-2	dideoxyhex-2	VERB
hjic-1161	51	10	-	-	ADJ
hjic-1161	51	11	ulose	ulose	ADJ
hjic-1161	51	12	(	(	PUNCT
hjic-1161	51	13	scheme	scheme	NOUN
hjic-1161	51	14	3	3	NUM
hjic-1161	51	15	)	)	PUNCT
hjic-1161	51	16	,	,	PUNCT
hjic-1161	51	17	n	n	CCONJ
hjic-1161	51	18	-	-	PUNCT
hjic-1161	51	19	cbz-3	cbz-3	NOUN
hjic-1161	51	20	-	-	PUNCT
hjic-1161	51	21	aminopropanoic	aminopropanoic	ADJ
hjic-1161	51	22	acid	acid	NOUN
hjic-1161	51	23	was	be	AUX
hjic-1161	51	24	the	the	DET
hjic-1161	51	25	dominant	dominant	ADJ
hjic-1161	51	26	main	main	ADJ
hjic-1161	51	27	product	product	NOUN
hjic-1161	51	28	following	follow	VERB
hjic-1161	51	29	our	our	PRON
hjic-1161	51	30	first	first	ADJ
hjic-1161	51	31	attempt	attempt	NOUN
hjic-1161	51	32	,	,	PUNCT
hjic-1161	51	33	with	with	SCONJ
hjic-1161	51	34	only	only	ADV
hjic-1161	51	35	2	2	NUM
hjic-1161	51	36	%	%	NOUN
hjic-1161	51	37	of	of	ADP
hjic-1161	51	38	the	the	DET
hjic-1161	51	39	target	target	NOUN
hjic-1161	51	40	product	product	NOUN
hjic-1161	51	41	being	be	AUX
hjic-1161	51	42	formed	form	VERB
hjic-1161	51	43	[	[	X
hjic-1161	51	44	25	25	NUM
hjic-1161	51	45	,	,	PUNCT
hjic-1161	51	46	26	26	NUM
hjic-1161	51	47	]	]	PUNCT
hjic-1161	51	48	.	.	PUNCT
hjic-1161	52	1	considering	consider	VERB
hjic-1161	52	2	the	the	DET
hjic-1161	52	3	complexity	complexity	NOUN
hjic-1161	52	4	of	of	ADP
hjic-1161	52	5	the	the	DET
hjic-1161	52	6	system	system	NOUN
hjic-1161	52	7	,	,	PUNCT
hjic-1161	52	8	reaction	reaction	NOUN
hjic-1161	52	9	engineering	engineering	NOUN
hjic-1161	52	10	methodology	methodology	NOUN
hjic-1161	52	11	was	be	AUX
hjic-1161	52	12	applied	apply	VERB
hjic-1161	52	13	to	to	PART
hjic-1161	52	14	determine	determine	VERB
hjic-1161	52	15	the	the	DET
hjic-1161	52	16	reason	reason	NOUN
hjic-1161	52	17	behind	behind	ADP
hjic-1161	52	18	this	this	PRON
hjic-1161	52	19	.	.	PUNCT
hjic-1161	53	1	a	a	DET
hjic-1161	53	2	statistical	statistical	ADJ
hjic-1161	53	3	model	model	NOUN
hjic-1161	53	4	implied	imply	VERB
hjic-1161	53	5	the	the	DET
hjic-1161	53	6	occurrence	occurrence	NOUN
hjic-1161	53	7	of	of	ADP
hjic-1161	53	8	this	this	DET
hjic-1161	53	9	side	side	NOUN
hjic-1161	53	10	reaction	reaction	NOUN
hjic-1161	53	11	[	[	X
hjic-1161	53	12	25	25	NUM
hjic-1161	53	13	]	]	PUNCT
hjic-1161	53	14	which	which	PRON
hjic-1161	53	15	was	be	AUX
hjic-1161	53	16	later	later	ADV
hjic-1161	53	17	confirmed	confirm	VERB
hjic-1161	53	18	by	by	ADP
hjic-1161	53	19	kinetic	kinetic	ADJ
hjic-1161	53	20	studies	study	NOUN
hjic-1161	53	21	[	[	X
hjic-1161	53	22	26	26	NUM
hjic-1161	53	23	]	]	PUNCT
hjic-1161	53	24	.	.	PUNCT
hjic-1161	54	1	not	not	PART
hjic-1161	54	2	only	only	ADV
hjic-1161	54	3	did	do	AUX
hjic-1161	54	4	the	the	DET
hjic-1161	54	5	aforementioned	aforementioned	ADJ
hjic-1161	54	6	studies	study	NOUN
hjic-1161	54	7	reveal	reveal	VERB
hjic-1161	54	8	the	the	DET
hjic-1161	54	9	reasons	reason	NOUN
hjic-1161	54	10	for	for	ADP
hjic-1161	54	11	the	the	DET
hjic-1161	54	12	poor	poor	ADJ
hjic-1161	54	13	yield	yield	NOUN
hjic-1161	54	14	but	but	CCONJ
hjic-1161	54	15	also	also	ADV
hjic-1161	54	16	determined	determine	VERB
hjic-1161	54	17	how	how	SCONJ
hjic-1161	54	18	to	to	PART
hjic-1161	54	19	improve	improve	VERB
hjic-1161	54	20	it	it	PRON
hjic-1161	54	21	to	to	ADP
hjic-1161	54	22	between	between	ADP
hjic-1161	54	23	79	79	NUM
hjic-1161	54	24	and	and	CCONJ
hjic-1161	54	25	92	92	NUM
hjic-1161	54	26	%	%	NOUN
hjic-1161	54	27	,	,	PUNCT
hjic-1161	54	28	respectively	respectively	ADV
hjic-1161	54	29	.	.	PUNCT
hjic-1161	55	1	in	in	ADP
hjic-1161	55	2	many	many	ADJ
hjic-1161	55	3	cases	case	NOUN
hjic-1161	55	4	,	,	PUNCT
hjic-1161	55	5	although	although	SCONJ
hjic-1161	55	6	commercial	commercial	ADJ
hjic-1161	55	7	compounds	compound	NOUN
hjic-1161	55	8	that	that	PRON
hjic-1161	55	9	contain	contain	VERB
hjic-1161	55	10	small	small	ADJ
hjic-1161	55	11	quantities	quantity	NOUN
hjic-1161	55	12	of	of	ADP
hjic-1161	55	13	certain	certain	ADJ
hjic-1161	55	14	additives	additive	NOUN
hjic-1161	55	15	are	be	AUX
hjic-1161	55	16	purchased	purchase	VERB
hjic-1161	55	17	for	for	ADP
hjic-1161	55	18	research	research	NOUN
hjic-1161	55	19	purposes	purpose	NOUN
hjic-1161	55	20	,	,	PUNCT
hjic-1161	55	21	these	these	DET
hjic-1161	55	22	additives	additive	NOUN
hjic-1161	55	23	can	can	AUX
hjic-1161	55	24	also	also	ADV
hjic-1161	55	25	frequently	frequently	ADV
hjic-1161	55	26	act	act	VERB
hjic-1161	55	27	as	as	ADP
hjic-1161	55	28	enzyme	enzyme	NOUN
hjic-1161	55	29	inhibitors	inhibitor	NOUN
hjic-1161	55	30	,	,	PUNCT
hjic-1161	55	31	such	such	ADJ
hjic-1161	55	32	as	as	ADP
hjic-1161	55	33	in	in	ADP
hjic-1161	55	34	the	the	DET
hjic-1161	55	35	case	case	NOUN
hjic-1161	55	36	of	of	ADP
hjic-1161	55	37	4methoxyphenol	4methoxyphenol	NUM
hjic-1161	55	38	as	as	ADP
hjic-1161	55	39	a	a	DET
hjic-1161	55	40	stabilizer	stabilizer	NOUN
hjic-1161	55	41	of	of	ADP
hjic-1161	55	42	acrylonitrile	acrylonitrile	NOUN
hjic-1161	55	43	that	that	PRON
hjic-1161	55	44	was	be	AUX
hjic-1161	55	45	used	use	VERB
hjic-1161	55	46	as	as	ADP
hjic-1161	55	47	a	a	DET
hjic-1161	55	48	substrate	substrate	NOUN
hjic-1161	55	49	in	in	ADP
hjic-1161	55	50	one	one	NUM
hjic-1161	55	51	of	of	ADP
hjic-1161	55	52	the	the	DET
hjic-1161	55	53	reactions	reaction	NOUN
hjic-1161	55	54	studied	study	VERB
hjic-1161	55	55	by	by	ADP
hjic-1161	55	56	us	we	PRON
hjic-1161	55	57	[	[	X
hjic-1161	55	58	27	27	NUM
hjic-1161	55	59	]	]	PUNCT
hjic-1161	55	60	.	.	PUNCT
hjic-1161	56	1	in	in	ADP
hjic-1161	56	2	fact	fact	NOUN
hjic-1161	56	3	,	,	PUNCT
hjic-1161	56	4	this	this	PRON
hjic-1161	56	5	was	be	AUX
hjic-1161	56	6	one	one	NUM
hjic-1161	56	7	of	of	ADP
hjic-1161	56	8	the	the	DET
hjic-1161	56	9	crucial	crucial	ADJ
hjic-1161	56	10	reasons	reason	NOUN
hjic-1161	56	11	why	why	SCONJ
hjic-1161	56	12	it	it	PRON
hjic-1161	56	13	was	be	AUX
hjic-1161	56	14	not	not	PART
hjic-1161	56	15	possible	possible	ADJ
hjic-1161	56	16	to	to	PART
hjic-1161	56	17	obtain	obtain	VERB
hjic-1161	56	18	significant	significant	ADJ
hjic-1161	56	19	amounts	amount	NOUN
hjic-1161	56	20	of	of	ADP
hjic-1161	56	21	product	product	NOUN
hjic-1161	56	22	in	in	ADP
hjic-1161	56	23	any	any	DET
hjic-1161	56	24	reactor	reactor	NOUN
hjic-1161	56	25	.	.	PUNCT
hjic-1161	57	1	3	3	X
hjic-1161	57	2	.	.	X
hjic-1161	57	3	investigation	investigation	NOUN
hjic-1161	57	4	of	of	ADP
hjic-1161	57	5	the	the	DET
hjic-1161	57	6	kinetics	kinetic	NOUN
hjic-1161	57	7	of	of	ADP
hjic-1161	57	8	the	the	DET
hjic-1161	57	9	enzyme	enzyme	NOUN
hjic-1161	57	10	-	-	PUNCT
hjic-1161	57	11	catalysed	catalyse	VERB
hjic-1161	57	12	reaction	reaction	NOUN
hjic-1161	57	13	to	to	PART
hjic-1161	57	14	formally	formally	ADV
hjic-1161	57	15	identify	identify	VERB
hjic-1161	57	16	the	the	DET
hjic-1161	57	17	system	system	NOUN
hjic-1161	57	18	,	,	PUNCT
hjic-1161	57	19	the	the	DET
hjic-1161	57	20	effect	effect	NOUN
hjic-1161	57	21	of	of	ADP
hjic-1161	57	22	all	all	DET
hjic-1161	57	23	the	the	DET
hjic-1161	57	24	compounds	compound	NOUN
hjic-1161	57	25	present	present	ADJ
hjic-1161	57	26	in	in	ADP
hjic-1161	57	27	the	the	DET
hjic-1161	57	28	reaction	reaction	NOUN
hjic-1161	57	29	mixture	mixture	NOUN
hjic-1161	57	30	on	on	ADP
hjic-1161	57	31	the	the	DET
hjic-1161	57	32	enzyme	enzyme	NOUN
hjic-1161	57	33	activity	activity	NOUN
hjic-1161	57	34	/	/	SYM
hjic-1161	57	35	reaction	reaction	NOUN
hjic-1161	57	36	rate	rate	NOUN
hjic-1161	57	37	can	can	AUX
hjic-1161	57	38	be	be	AUX
hjic-1161	57	39	evaluated	evaluate	VERB
hjic-1161	57	40	.	.	PUNCT
hjic-1161	58	1	during	during	ADP
hjic-1161	58	2	these	these	DET
hjic-1161	58	3	measurements	measurement	NOUN
hjic-1161	58	4	,	,	PUNCT
hjic-1161	58	5	the	the	DET
hjic-1161	58	6	effects	effect	NOUN
hjic-1161	58	7	of	of	ADP
hjic-1161	58	8	all	all	DET
hjic-1161	58	9	the	the	DET
hjic-1161	58	10	compounds	compound	NOUN
hjic-1161	58	11	on	on	ADP
hjic-1161	58	12	the	the	DET
hjic-1161	58	13	enzyme	enzyme	NOUN
hjic-1161	58	14	activity	activity	NOUN
hjic-1161	58	15	can	can	AUX
hjic-1161	58	16	be	be	AUX
hjic-1161	58	17	measured	measure	VERB
hjic-1161	58	18	and	and	CCONJ
hjic-1161	58	19	,	,	PUNCT
hjic-1161	58	20	in	in	ADP
hjic-1161	58	21	many	many	ADJ
hjic-1161	58	22	cases	case	NOUN
hjic-1161	58	23	,	,	PUNCT
hjic-1161	58	24	substrate	substrate	NOUN
hjic-1161	58	25	,	,	PUNCT
hjic-1161	58	26	intermediate	intermediate	ADJ
hjic-1161	58	27	and	and	CCONJ
hjic-1161	58	28	product	product	NOUN
hjic-1161	58	29	inhibition	inhibition	NOUN
hjic-1161	58	30	can	can	AUX
hjic-1161	58	31	be	be	AUX
hjic-1161	58	32	detected	detect	VERB
hjic-1161	58	33	,	,	PUNCT
hjic-1161	58	34	which	which	PRON
hjic-1161	58	35	subsequently	subsequently	ADV
hjic-1161	58	36	help	help	VERB
hjic-1161	58	37	with	with	ADP
hjic-1161	58	38	regard	regard	NOUN
hjic-1161	58	39	to	to	ADP
hjic-1161	58	40	decisionmaking	decisionmaking	NOUN
hjic-1161	58	41	and	and	CCONJ
hjic-1161	58	42	selection	selection	NOUN
hjic-1161	58	43	of	of	ADP
hjic-1161	58	44	the	the	DET
hjic-1161	58	45	reactor	reactor	NOUN
hjic-1161	58	46	mode	mode	NOUN
hjic-1161	58	47	to	to	PART
hjic-1161	58	48	be	be	AUX
hjic-1161	58	49	used	use	VERB
hjic-1161	58	50	for	for	ADP
hjic-1161	58	51	the	the	DET
hjic-1161	58	52	reaction	reaction	NOUN
hjic-1161	58	53	.	.	PUNCT
hjic-1161	59	1	some	some	DET
hjic-1161	59	2	examples	example	NOUN
hjic-1161	59	3	of	of	ADP
hjic-1161	59	4	reactor	reactor	NOUN
hjic-1161	59	5	designs	design	NOUN
hjic-1161	59	6	that	that	PRON
hjic-1161	59	7	can	can	AUX
hjic-1161	59	8	be	be	AUX
hjic-1161	59	9	applied	apply	VERB
hjic-1161	59	10	,	,	PUNCT
hjic-1161	59	11	according	accord	VERB
hjic-1161	59	12	to	to	ADP
hjic-1161	59	13	the	the	DET
hjic-1161	59	14	properties	property	NOUN
hjic-1161	59	15	of	of	ADP
hjic-1161	59	16	the	the	DET
hjic-1161	59	17	studied	study	VERB
hjic-1161	59	18	reaction	reaction	NOUN
hjic-1161	59	19	and	and	CCONJ
hjic-1161	59	20	desired	desire	VERB
hjic-1161	59	21	outcome	outcome	NOUN
hjic-1161	59	22	,	,	PUNCT
hjic-1161	59	23	are	be	AUX
hjic-1161	59	24	given	give	VERB
hjic-1161	59	25	in	in	ADP
hjic-1161	59	26	fig	fig	NOUN
hjic-1161	59	27	.	.	PUNCT
hjic-1161	60	1	2	2	X
hjic-1161	60	2	.	.	X
hjic-1161	60	3	in	in	ADP
hjic-1161	60	4	theory	theory	NOUN
hjic-1161	60	5	,	,	PUNCT
hjic-1161	60	6	it	it	PRON
hjic-1161	60	7	is	be	AUX
hjic-1161	60	8	known	know	VERB
hjic-1161	60	9	that	that	SCONJ
hjic-1161	60	10	the	the	DET
hjic-1161	60	11	fed	fed	PROPN
hjic-1161	60	12	-	-	PUNCT
hjic-1161	60	13	batch	batch	NOUN
hjic-1161	60	14	bioreactor	bioreactor	NOUN
hjic-1161	60	15	is	be	AUX
hjic-1161	60	16	a	a	DET
hjic-1161	60	17	favourable	favourable	ADJ
hjic-1161	60	18	choice	choice	NOUN
hjic-1161	60	19	for	for	ADP
hjic-1161	60	20	reactions	reaction	NOUN
hjic-1161	60	21	subjected	subject	VERB
hjic-1161	60	22	to	to	ADP
hjic-1161	60	23	substrate	substrate	NOUN
hjic-1161	60	24	inhibition	inhibition	NOUN
hjic-1161	60	25	to	to	PART
hjic-1161	60	26	increase	increase	VERB
hjic-1161	60	27	the	the	DET
hjic-1161	60	28	concentration	concentration	NOUN
hjic-1161	60	29	of	of	ADP
hjic-1161	60	30	the	the	DET
hjic-1161	60	31	obtained	obtain	VERB
hjic-1161	60	32	product	product	NOUN
hjic-1161	60	33	[	[	X
hjic-1161	60	34	31	31	NUM
hjic-1161	60	35	]	]	PUNCT
hjic-1161	60	36	.	.	PUNCT
hjic-1161	61	1	(	(	PUNCT
hjic-1161	61	2	a	a	X
hjic-1161	61	3	)	)	PUNCT
hjic-1161	61	4	(	(	PUNCT
hjic-1161	61	5	b	b	X
hjic-1161	61	6	)	)	PUNCT
hjic-1161	61	7	(	(	PUNCT
hjic-1161	61	8	c	c	X
hjic-1161	61	9	)	)	PUNCT
hjic-1161	61	10	figure	figure	NOUN
hjic-1161	61	11	2	2	NUM
hjic-1161	61	12	:	:	PUNCT
hjic-1161	61	13	schemes	scheme	NOUN
hjic-1161	61	14	of	of	ADP
hjic-1161	61	15	different	different	ADJ
hjic-1161	61	16	reactors	reactor	NOUN
hjic-1161	61	17	applied	apply	VERB
hjic-1161	61	18	in	in	ADP
hjic-1161	61	19	biocatalysis	biocatalysis	NOUN
hjic-1161	61	20	:	:	PUNCT
hjic-1161	61	21	(	(	PUNCT
hjic-1161	61	22	a	a	X
hjic-1161	61	23	)	)	PUNCT
hjic-1161	61	24	batch	batch	NOUN
hjic-1161	61	25	reactor	reactor	NOUN
hjic-1161	61	26	,	,	PUNCT
hjic-1161	61	27	(	(	PUNCT
hjic-1161	61	28	b	b	X
hjic-1161	61	29	)	)	PUNCT
hjic-1161	61	30	fed	feed	VERB
hjic-1161	61	31	-	-	PUNCT
hjic-1161	61	32	batch	batch	NOUN
hjic-1161	61	33	bioreactor	bioreactor	NOUN
hjic-1161	61	34	,	,	PUNCT
hjic-1161	61	35	(	(	PUNCT
hjic-1161	61	36	c	c	X
hjic-1161	61	37	)	)	PUNCT
hjic-1161	61	38	continuous	continuous	ADJ
hjic-1161	61	39	stirred	stir	VERB
hjic-1161	61	40	tank	tank	NOUN
hjic-1161	61	41	reactor	reactor	NOUN
hjic-1161	61	42	for	for	ADP
hjic-1161	61	43	product	product	NOUN
hjic-1161	61	44	-	-	PUNCT
hjic-1161	61	45	inhibited	inhibit	VERB
hjic-1161	61	46	reactions	reaction	NOUN
hjic-1161	61	47	,	,	PUNCT
hjic-1161	61	48	a	a	DET
hjic-1161	61	49	continuous	continuous	ADJ
hjic-1161	61	50	stirred	stir	VERB
hjic-1161	61	51	tank	tank	NOUN
hjic-1161	61	52	reactor	reactor	NOUN
hjic-1161	61	53	operating	operate	VERB
hjic-1161	61	54	at	at	ADP
hjic-1161	61	55	the	the	DET
hjic-1161	61	56	maximum	maximum	ADJ
hjic-1161	61	57	concentration	concentration	NOUN
hjic-1161	61	58	of	of	ADP
hjic-1161	61	59	the	the	DET
hjic-1161	61	60	product	product	NOUN
hjic-1161	61	61	is	be	AUX
hjic-1161	61	62	not	not	PART
hjic-1161	61	63	recommended	recommend	VERB
hjic-1161	61	64	and	and	CCONJ
hjic-1161	61	65	,	,	PUNCT
hjic-1161	61	66	therefore	therefore	ADV
hjic-1161	61	67	,	,	PUNCT
hjic-1161	61	68	the	the	DET
hjic-1161	61	69	resultant	resultant	NOUN
hjic-1161	61	70	enzyme	enzyme	NOUN
hjic-1161	61	71	activity	activity	NOUN
hjic-1161	61	72	is	be	AUX
hjic-1161	61	73	unsatisfactory	unsatisfactory	ADJ
hjic-1161	61	74	[	[	PUNCT
hjic-1161	61	75	32	32	NUM
hjic-1161	61	76	,	,	PUNCT
hjic-1161	61	77	33	33	NUM
hjic-1161	61	78	]	]	PUNCT
hjic-1161	61	79	.	.	PUNCT
hjic-1161	62	1	in	in	ADP
hjic-1161	62	2	practice	practice	NOUN
hjic-1161	62	3	,	,	PUNCT
hjic-1161	62	4	reactions	reaction	NOUN
hjic-1161	62	5	are	be	AUX
hjic-1161	62	6	rarely	rarely	ADV
hjic-1161	62	7	inhibited	inhibit	VERB
hjic-1161	62	8	by	by	ADP
hjic-1161	62	9	a	a	DET
hjic-1161	62	10	single	single	ADJ
hjic-1161	62	11	compound	compound	NOUN
hjic-1161	62	12	,	,	PUNCT
hjic-1161	62	13	moreover	moreover	ADV
hjic-1161	62	14	,	,	PUNCT
hjic-1161	62	15	in	in	ADP
hjic-1161	62	16	many	many	ADJ
hjic-1161	62	17	cases	case	NOUN
hjic-1161	62	18	,	,	PUNCT
hjic-1161	62	19	several	several	ADJ
hjic-1161	62	20	important	important	ADJ
hjic-1161	62	21	inhibitions	inhibition	NOUN
hjic-1161	62	22	and/or	and/or	CCONJ
hjic-1161	62	23	side	side	NOUN
hjic-1161	62	24	reactions	reaction	NOUN
hjic-1161	62	25	take	take	VERB
hjic-1161	62	26	place	place	NOUN
hjic-1161	62	27	.	.	PUNCT
hjic-1161	63	1	therefore	therefore	ADV
hjic-1161	63	2	,	,	PUNCT
hjic-1161	63	3	the	the	DET
hjic-1161	63	4	reactor	reactor	NOUN
hjic-1161	63	5	mode	mode	NOUN
hjic-1161	63	6	can	can	AUX
hjic-1161	63	7	not	not	PART
hjic-1161	63	8	be	be	AUX
hjic-1161	63	9	easily	easily	ADV
hjic-1161	63	10	set	set	VERB
hjic-1161	63	11	by	by	ADP
hjic-1161	63	12	viewing	view	VERB
hjic-1161	63	13	the	the	DET
hjic-1161	63	14	results	result	NOUN
hjic-1161	63	15	of	of	ADP
hjic-1161	63	16	the	the	DET
hjic-1161	63	17	effect	effect	NOUN
hjic-1161	63	18	of	of	ADP
hjic-1161	63	19	substrates	substrate	NOUN
hjic-1161	63	20	on	on	ADP
hjic-1161	63	21	the	the	DET
hjic-1161	63	22	reaction	reaction	NOUN
hjic-1161	63	23	rate	rate	NOUN
hjic-1161	63	24	.	.	PUNCT
hjic-1161	64	1	in	in	ADP
hjic-1161	64	2	these	these	DET
hjic-1161	64	3	cases	case	NOUN
hjic-1161	64	4	,	,	PUNCT
hjic-1161	64	5	kinetic	kinetic	ADJ
hjic-1161	64	6	models	model	NOUN
hjic-1161	64	7	help	help	AUX
hjic-1161	64	8	simulate	simulate	VERB
hjic-1161	64	9	different	different	ADJ
hjic-1161	64	10	scenarios	scenario	NOUN
hjic-1161	64	11	and	and	CCONJ
hjic-1161	64	12	enable	enable	VERB
hjic-1161	64	13	the	the	DET
hjic-1161	64	14	best	good	ADJ
hjic-1161	64	15	choice	choice	NOUN
hjic-1161	64	16	for	for	ADP
hjic-1161	64	17	the	the	DET
hjic-1161	64	18	studied	study	VERB
hjic-1161	64	19	reaction	reaction	NOUN
hjic-1161	64	20	system	system	NOUN
hjic-1161	64	21	to	to	PART
hjic-1161	64	22	be	be	AUX
hjic-1161	64	23	made	make	VERB
hjic-1161	64	24	[	[	PUNCT
hjic-1161	64	25	13	13	NUM
hjic-1161	64	26	]	]	PUNCT
hjic-1161	64	27	.	.	PUNCT
hjic-1161	65	1	the	the	DET
hjic-1161	65	2	simulations	simulation	NOUN
hjic-1161	65	3	of	of	ADP
hjic-1161	65	4	a	a	DET
hjic-1161	65	5	relatively	relatively	ADV
hjic-1161	65	6	simple	simple	ADJ
hjic-1161	65	7	doublesubstrate	doublesubstrate	NOUN
hjic-1161	65	8	reaction	reaction	NOUN
hjic-1161	65	9	in	in	ADP
hjic-1161	65	10	which	which	PRON
hjic-1161	65	11	the	the	DET
hjic-1161	65	12	kinetics	kinetic	NOUN
hjic-1161	65	13	can	can	AUX
hjic-1161	65	14	be	be	AUX
hjic-1161	65	15	described	describe	VERB
hjic-1161	65	16	by	by	ADP
hjic-1161	65	17	double	double	ADJ
hjic-1161	65	18	michaelis	michaeli	NOUN
hjic-1161	65	19	-	-	PUNCT
hjic-1161	65	20	menten	menten	VERB
hjic-1161	65	21	kinetics	kinetic	NOUN
hjic-1161	65	22	with	with	ADP
hjic-1161	65	23	both	both	DET
hjic-1161	65	24	substrate	substrate	NOUN
hjic-1161	65	25	and	and	CCONJ
hjic-1161	65	26	product	product	NOUN
hjic-1161	65	27	inhibition	inhibition	NOUN
hjic-1161	65	28	are	be	AUX
hjic-1161	65	29	presented	present	VERB
hjic-1161	65	30	in	in	ADP
hjic-1161	65	31	fig	fig	NOUN
hjic-1161	65	32	.	.	PUNCT
hjic-1161	66	1	3	3	X
hjic-1161	66	2	.	.	X
hjic-1161	66	3	the	the	DET
hjic-1161	66	4	impact	impact	NOUN
hjic-1161	66	5	of	of	ADP
hjic-1161	66	6	reaction	reaction	NOUN
hjic-1161	66	7	conditions	condition	NOUN
hjic-1161	66	8	on	on	ADP
hjic-1161	66	9	substrate	substrate	NOUN
hjic-1161	66	10	conversion	conversion	NOUN
hjic-1161	66	11	and	and	CCONJ
hjic-1161	66	12	volumetric	volumetric	NOUN
hjic-1161	66	13	productivity	productivity	NOUN
hjic-1161	66	14	in	in	ADP
hjic-1161	66	15	the	the	DET
hjic-1161	66	16	batch	batch	NOUN
hjic-1161	66	17	reactor	reactor	NOUN
hjic-1161	66	18	is	be	AUX
hjic-1161	66	19	presented	present	VERB
hjic-1161	66	20	in	in	ADP
hjic-1161	66	21	figs	fig	NOUN
hjic-1161	66	22	.	.	PUNCT
hjic-1161	67	1	3a	3a	NUM
hjic-1161	67	2	and	and	CCONJ
hjic-1161	67	3	3b	3b	NUM
hjic-1161	67	4	,	,	PUNCT
hjic-1161	67	5	while	while	SCONJ
hjic-1161	67	6	3c	3c	NUM
hjic-1161	67	7	and	and	CCONJ
hjic-1161	67	8	3d	3d	PROPN
hjic-1161	67	9	show	show	VERB
hjic-1161	67	10	the	the	DET
hjic-1161	67	11	same	same	ADJ
hjic-1161	67	12	for	for	ADP
hjic-1161	67	13	the	the	DET
hjic-1161	67	14	continuous	continuous	ADJ
hjic-1161	67	15	stirred	stir	VERB
hjic-1161	67	16	tank	tank	NOUN
hjic-1161	67	17	reactor	reactor	NOUN
hjic-1161	67	18	(	(	PUNCT
hjic-1161	67	19	cstr	cstr	NOUN
hjic-1161	67	20	)	)	PUNCT
hjic-1161	67	21	.	.	PUNCT
hjic-1161	68	1	substrate	substrate	NOUN
hjic-1161	68	2	conversion	conversion	NOUN
hjic-1161	68	3	is	be	AUX
hjic-1161	68	4	governed	govern	VERB
hjic-1161	68	5	by	by	ADP
hjic-1161	68	6	the	the	DET
hjic-1161	68	7	enzyme	enzyme	NOUN
hjic-1161	68	8	concentration	concentration	NOUN
hjic-1161	68	9	as	as	ADV
hjic-1161	68	10	well	well	ADV
hjic-1161	68	11	as	as	ADP
hjic-1161	68	12	the	the	DET
hjic-1161	68	13	reaction	reaction	NOUN
hjic-1161	68	14	time	time	NOUN
hjic-1161	68	15	and	and	CCONJ
hjic-1161	68	16	residence	residence	NOUN
hjic-1161	68	17	time	time	NOUN
hjic-1161	68	18	in	in	ADP
hjic-1161	68	19	the	the	DET
hjic-1161	68	20	batch	batch	NOUN
hjic-1161	68	21	reactor	reactor	NOUN
hjic-1161	68	22	and	and	CCONJ
hjic-1161	68	23	cstr	cstr	NOUN
hjic-1161	68	24	,	,	PUNCT
hjic-1161	68	25	respectively	respectively	ADV
hjic-1161	68	26	.	.	PUNCT
hjic-1161	69	1	the	the	DET
hjic-1161	69	2	main	main	ADJ
hjic-1161	69	3	difference	difference	NOUN
hjic-1161	69	4	that	that	PRON
hjic-1161	69	5	can	can	AUX
hjic-1161	69	6	be	be	AUX
hjic-1161	69	7	hungarian	hungarian	ADJ
hjic-1161	69	8	journal	journal	NOUN
hjic-1161	69	9	of	of	ADP
hjic-1161	69	10	industry	industry	NOUN
hjic-1161	69	11	and	and	CCONJ
hjic-1161	69	12	chemistry	chemistry	NOUN
hjic-1161	69	13	enzyme	enzyme	NOUN
hjic-1161	69	14	reaction	reaction	NOUN
hjic-1161	69	15	engineering	engineering	NOUN
hjic-1161	69	16	as	as	ADP
hjic-1161	69	17	a	a	DET
hjic-1161	69	18	tool	tool	NOUN
hjic-1161	69	19	49	49	NUM
hjic-1161	69	20	(	(	PUNCT
hjic-1161	69	21	a	a	NOUN
hjic-1161	69	22	)	)	PUNCT
hjic-1161	69	23	(	(	PUNCT
hjic-1161	69	24	b	b	X
hjic-1161	69	25	)	)	PUNCT
hjic-1161	69	26	(	(	PUNCT
hjic-1161	69	27	c	c	X
hjic-1161	69	28	)	)	PUNCT
hjic-1161	69	29	(	(	PUNCT
hjic-1161	69	30	d	d	X
hjic-1161	69	31	)	)	PUNCT
hjic-1161	69	32	figure	figure	NOUN
hjic-1161	69	33	3	3	NUM
hjic-1161	69	34	:	:	PUNCT
hjic-1161	69	35	model	model	NOUN
hjic-1161	69	36	simulations	simulation	NOUN
hjic-1161	69	37	demonstrating	demonstrate	VERB
hjic-1161	69	38	the	the	DET
hjic-1161	69	39	impact	impact	NOUN
hjic-1161	69	40	of	of	ADP
hjic-1161	69	41	the	the	DET
hjic-1161	69	42	reaction	reaction	NOUN
hjic-1161	69	43	conditions	condition	NOUN
hjic-1161	69	44	on	on	ADP
hjic-1161	69	45	the	the	DET
hjic-1161	69	46	conversion	conversion	NOUN
hjic-1161	69	47	and	and	CCONJ
hjic-1161	69	48	volumetric	volumetric	NOUN
hjic-1161	69	49	productivity	productivity	NOUN
hjic-1161	69	50	in	in	ADP
hjic-1161	69	51	the	the	DET
hjic-1161	69	52	batch	batch	NOUN
hjic-1161	69	53	and	and	CCONJ
hjic-1161	69	54	continuous	continuous	ADJ
hjic-1161	69	55	stirred	stir	VERB
hjic-1161	69	56	tank	tank	NOUN
hjic-1161	69	57	reactors	reactor	NOUN
hjic-1161	69	58	observed	observe	VERB
hjic-1161	69	59	is	be	AUX
hjic-1161	69	60	in	in	ADP
hjic-1161	69	61	terms	term	NOUN
hjic-1161	69	62	of	of	ADP
hjic-1161	69	63	volumetric	volumetric	NOUN
hjic-1161	69	64	productivity	productivity	NOUN
hjic-1161	69	65	,	,	PUNCT
hjic-1161	69	66	which	which	PRON
hjic-1161	69	67	explains	explain	VERB
hjic-1161	69	68	why	why	SCONJ
hjic-1161	69	69	continuous	continuous	ADJ
hjic-1161	69	70	processes	process	NOUN
hjic-1161	69	71	are	be	AUX
hjic-1161	69	72	currently	currently	ADV
hjic-1161	69	73	in	in	ADP
hjic-1161	69	74	the	the	DET
hjic-1161	69	75	spotlight	spotlight	NOUN
hjic-1161	69	76	.	.	PUNCT
hjic-1161	70	1	in	in	ADP
hjic-1161	70	2	this	this	DET
hjic-1161	70	3	simulation	simulation	NOUN
hjic-1161	70	4	,	,	PUNCT
hjic-1161	70	5	the	the	DET
hjic-1161	70	6	maximum	maximum	ADJ
hjic-1161	70	7	volumetric	volumetric	NOUN
hjic-1161	70	8	productivity	productivity	NOUN
hjic-1161	70	9	of	of	ADP
hjic-1161	70	10	the	the	DET
hjic-1161	70	11	cstr	cstr	NOUN
hjic-1161	70	12	is	be	AUX
hjic-1161	70	13	fourfold	fourfold	VERB
hjic-1161	70	14	greater	great	ADJ
hjic-1161	70	15	than	than	ADP
hjic-1161	70	16	that	that	PRON
hjic-1161	70	17	of	of	ADP
hjic-1161	70	18	the	the	DET
hjic-1161	70	19	batch	batch	NOUN
hjic-1161	70	20	reactor	reactor	NOUN
hjic-1161	70	21	.	.	PUNCT
hjic-1161	71	1	nevertheless	nevertheless	ADV
hjic-1161	71	2	,	,	PUNCT
hjic-1161	71	3	it	it	PRON
hjic-1161	71	4	must	must	AUX
hjic-1161	71	5	be	be	AUX
hjic-1161	71	6	noted	note	VERB
hjic-1161	71	7	that	that	SCONJ
hjic-1161	71	8	the	the	DET
hjic-1161	71	9	operational	operational	ADJ
hjic-1161	71	10	stability	stability	NOUN
hjic-1161	71	11	of	of	ADP
hjic-1161	71	12	the	the	DET
hjic-1161	71	13	enzyme	enzyme	NOUN
hjic-1161	71	14	is	be	AUX
hjic-1161	71	15	important	important	ADJ
hjic-1161	71	16	and	and	CCONJ
hjic-1161	71	17	that	that	SCONJ
hjic-1161	71	18	the	the	DET
hjic-1161	71	19	enzyme	enzyme	NOUN
hjic-1161	71	20	activity	activity	NOUN
hjic-1161	71	21	was	be	AUX
hjic-1161	71	22	assumed	assume	VERB
hjic-1161	71	23	to	to	PART
hjic-1161	71	24	be	be	AUX
hjic-1161	71	25	constant	constant	ADJ
hjic-1161	71	26	.	.	PUNCT
hjic-1161	72	1	in	in	ADP
hjic-1161	72	2	practice	practice	NOUN
hjic-1161	72	3	,	,	PUNCT
hjic-1161	72	4	since	since	SCONJ
hjic-1161	72	5	the	the	DET
hjic-1161	72	6	enzyme	enzyme	NOUN
hjic-1161	72	7	activity	activity	NOUN
hjic-1161	72	8	inevitably	inevitably	ADV
hjic-1161	72	9	drops	drop	VERB
hjic-1161	72	10	over	over	ADP
hjic-1161	72	11	time	time	NOUN
hjic-1161	72	12	and	and	CCONJ
hjic-1161	72	13	,	,	PUNCT
hjic-1161	72	14	therefore	therefore	ADV
hjic-1161	72	15	,	,	PUNCT
hjic-1161	72	16	enzymes	enzyme	NOUN
hjic-1161	72	17	must	must	AUX
hjic-1161	72	18	be	be	AUX
hjic-1161	72	19	stabilized	stabilize	VERB
hjic-1161	72	20	by	by	ADP
hjic-1161	72	21	a	a	DET
hjic-1161	72	22	form	form	NOUN
hjic-1161	72	23	of	of	ADP
hjic-1161	72	24	immobilization	immobilization	NOUN
hjic-1161	72	25	,	,	PUNCT
hjic-1161	72	26	ensuring	ensure	VERB
hjic-1161	72	27	the	the	DET
hjic-1161	72	28	continuous	continuous	ADJ
hjic-1161	72	29	process	process	NOUN
hjic-1161	72	30	functions	function	NOUN
hjic-1161	72	31	is	be	AUX
hjic-1161	72	32	not	not	PART
hjic-1161	72	33	a	a	DET
hjic-1161	72	34	straightforward	straightforward	ADJ
hjic-1161	72	35	task	task	NOUN
hjic-1161	72	36	.	.	PUNCT
hjic-1161	73	1	the	the	DET
hjic-1161	73	2	first	first	ADJ
hjic-1161	73	3	step	step	NOUN
hjic-1161	73	4	to	to	PART
hjic-1161	73	5	investigate	investigate	VERB
hjic-1161	73	6	enzyme	enzyme	NOUN
hjic-1161	73	7	kinetics	kinetic	NOUN
hjic-1161	73	8	is	be	AUX
hjic-1161	73	9	to	to	PART
hjic-1161	73	10	find	find	VERB
hjic-1161	73	11	an	an	DET
hjic-1161	73	12	appropriate	appropriate	ADJ
hjic-1161	73	13	method	method	NOUN
hjic-1161	73	14	that	that	PRON
hjic-1161	73	15	will	will	AUX
hjic-1161	73	16	result	result	VERB
hjic-1161	73	17	in	in	ADP
hjic-1161	73	18	the	the	DET
hjic-1161	73	19	rapid	rapid	ADJ
hjic-1161	73	20	collection	collection	NOUN
hjic-1161	73	21	of	of	ADP
hjic-1161	73	22	enzyme	enzyme	NOUN
hjic-1161	73	23	kinetic	kinetic	ADJ
hjic-1161	73	24	data	datum	NOUN
hjic-1161	73	25	.	.	PUNCT
hjic-1161	74	1	this	this	PRON
hjic-1161	74	2	can	can	AUX
hjic-1161	74	3	be	be	AUX
hjic-1161	74	4	done	do	VERB
hjic-1161	74	5	by	by	ADP
hjic-1161	74	6	applying	apply	VERB
hjic-1161	74	7	a	a	DET
hjic-1161	74	8	spectrophotometric	spectrophotometric	ADJ
hjic-1161	74	9	enzyme	enzyme	NOUN
hjic-1161	74	10	assay	assay	NOUN
hjic-1161	74	11	and	and	CCONJ
hjic-1161	74	12	microtiter	microtiter	ADJ
hjic-1161	74	13	plate	plate	NOUN
hjic-1161	74	14	reader	reader	NOUN
hjic-1161	74	15	,	,	PUNCT
hjic-1161	74	16	however	however	ADV
hjic-1161	74	17	,	,	PUNCT
hjic-1161	74	18	should	should	AUX
hjic-1161	74	19	these	these	DET
hjic-1161	74	20	methods	method	NOUN
hjic-1161	74	21	be	be	AUX
hjic-1161	74	22	unavailable	unavailable	ADJ
hjic-1161	74	23	,	,	PUNCT
hjic-1161	74	24	this	this	PRON
hjic-1161	74	25	can	can	AUX
hjic-1161	74	26	also	also	ADV
hjic-1161	74	27	be	be	AUX
hjic-1161	74	28	achieved	achieve	VERB
hjic-1161	74	29	in	in	ADP
hjic-1161	74	30	a	a	DET
hjic-1161	74	31	traditional	traditional	ADJ
hjic-1161	74	32	manner	manner	NOUN
hjic-1161	74	33	by	by	ADP
hjic-1161	74	34	determining	determine	VERB
hjic-1161	74	35	the	the	DET
hjic-1161	74	36	initial	initial	ADJ
hjic-1161	74	37	reaction	reaction	NOUN
hjic-1161	74	38	rates	rate	NOUN
hjic-1161	74	39	from	from	ADP
hjic-1161	74	40	hplc	hplc	PROPN
hjic-1161	74	41	or	or	CCONJ
hjic-1161	74	42	gc	gc	PROPN
hjic-1161	74	43	data	datum	NOUN
hjic-1161	74	44	with	with	ADP
hjic-1161	74	45	regard	regard	NOUN
hjic-1161	74	46	to	to	ADP
hjic-1161	74	47	the	the	DET
hjic-1161	74	48	concentrations	concentration	NOUN
hjic-1161	74	49	of	of	ADP
hjic-1161	74	50	substrates	substrate	NOUN
hjic-1161	74	51	and	and	CCONJ
hjic-1161	74	52	products	product	NOUN
hjic-1161	74	53	[	[	X
hjic-1161	74	54	13	13	NUM
hjic-1161	74	55	]	]	PUNCT
hjic-1161	74	56	.	.	PUNCT
hjic-1161	75	1	given	give	VERB
hjic-1161	75	2	that	that	SCONJ
hjic-1161	75	3	data	data	NOUN
hjic-1161	75	4	collection	collection	NOUN
hjic-1161	75	5	must	must	AUX
hjic-1161	75	6	be	be	AUX
hjic-1161	75	7	accurate	accurate	ADJ
hjic-1161	75	8	and	and	CCONJ
hjic-1161	75	9	reliable	reliable	ADJ
hjic-1161	75	10	,	,	PUNCT
hjic-1161	75	11	analytics	analytic	NOUN
hjic-1161	75	12	is	be	AUX
hjic-1161	75	13	the	the	DET
hjic-1161	75	14	foundation	foundation	NOUN
hjic-1161	75	15	of	of	ADP
hjic-1161	75	16	the	the	DET
hjic-1161	75	17	research	research	NOUN
hjic-1161	75	18	.	.	PUNCT
hjic-1161	76	1	data	datum	NOUN
hjic-1161	76	2	must	must	AUX
hjic-1161	76	3	be	be	AUX
hjic-1161	76	4	reproducible	reproducible	ADJ
hjic-1161	76	5	and	and	CCONJ
hjic-1161	76	6	trustworthy	trustworthy	ADJ
hjic-1161	76	7	to	to	PART
hjic-1161	76	8	be	be	AUX
hjic-1161	76	9	used	use	VERB
hjic-1161	76	10	for	for	ADP
hjic-1161	76	11	modelling	modelling	NOUN
hjic-1161	76	12	.	.	PUNCT
hjic-1161	77	1	an	an	DET
hjic-1161	77	2	example	example	NOUN
hjic-1161	77	3	of	of	ADP
hjic-1161	77	4	kinetic	kinetic	ADJ
hjic-1161	77	5	data	datum	NOUN
hjic-1161	77	6	is	be	AUX
hjic-1161	77	7	presented	present	VERB
hjic-1161	77	8	in	in	ADP
hjic-1161	77	9	fig	fig	NOUN
hjic-1161	77	10	.	.	PUNCT
hjic-1161	78	1	4	4	NUM
hjic-1161	78	2	where	where	SCONJ
hjic-1161	78	3	the	the	DET
hjic-1161	78	4	grey	grey	ADJ
hjic-1161	78	5	line	line	NOUN
hjic-1161	78	6	denotes	denote	VERB
hjic-1161	78	7	the	the	DET
hjic-1161	78	8	experiment	experiment	NOUN
hjic-1161	78	9	where	where	SCONJ
hjic-1161	78	10	the	the	DET
hjic-1161	78	11	enzyme	enzyme	NOUN
hjic-1161	78	12	concentration	concentration	NOUN
hjic-1161	78	13	was	be	AUX
hjic-1161	78	14	too	too	ADV
hjic-1161	78	15	high	high	ADJ
hjic-1161	78	16	.	.	PUNCT
hjic-1161	79	1	furthermore	furthermore	ADV
hjic-1161	79	2	,	,	PUNCT
hjic-1161	79	3	even	even	ADV
hjic-1161	79	4	though	though	SCONJ
hjic-1161	79	5	the	the	DET
hjic-1161	79	6	linear	linear	ADJ
hjic-1161	79	7	dependence	dependence	NOUN
hjic-1161	79	8	of	of	ADP
hjic-1161	79	9	absorbance	absorbance	NOUN
hjic-1161	79	10	over	over	ADP
hjic-1161	79	11	time	time	NOUN
hjic-1161	79	12	is	be	AUX
hjic-1161	79	13	obvious	obvious	ADJ
hjic-1161	79	14	in	in	ADP
hjic-1161	79	15	the	the	DET
hjic-1161	79	16	initial	initial	ADJ
hjic-1161	79	17	part	part	NOUN
hjic-1161	79	18	of	of	ADP
hjic-1161	79	19	the	the	DET
hjic-1161	79	20	curve	curve	NOUN
hjic-1161	79	21	,	,	PUNCT
hjic-1161	79	22	the	the	DET
hjic-1161	79	23	error	error	NOUN
hjic-1161	79	24	of	of	ADP
hjic-1161	79	25	such	such	ADJ
hjic-1161	79	26	measurements	measurement	NOUN
hjic-1161	79	27	can	can	AUX
hjic-1161	79	28	be	be	AUX
hjic-1161	79	29	high	high	ADJ
hjic-1161	79	30	and	and	CCONJ
hjic-1161	79	31	depends	depend	VERB
hjic-1161	79	32	on	on	ADP
hjic-1161	79	33	the	the	DET
hjic-1161	79	34	individual	individual	ADJ
hjic-1161	79	35	measuring	measuring	NOUN
hjic-1161	79	36	.	.	PUNCT
hjic-1161	80	1	on	on	ADP
hjic-1161	80	2	the	the	DET
hjic-1161	80	3	other	other	ADJ
hjic-1161	80	4	hand	hand	NOUN
hjic-1161	80	5	,	,	PUNCT
hjic-1161	80	6	the	the	DET
hjic-1161	80	7	black	black	ADJ
hjic-1161	80	8	line	line	NOUN
hjic-1161	80	9	clearly	clearly	ADV
hjic-1161	80	10	figure	figure	VERB
hjic-1161	80	11	4	4	NUM
hjic-1161	80	12	:	:	PUNCT
hjic-1161	80	13	the	the	DET
hjic-1161	80	14	impact	impact	NOUN
hjic-1161	80	15	of	of	ADP
hjic-1161	80	16	enzyme	enzyme	NOUN
hjic-1161	80	17	concentration	concentration	NOUN
hjic-1161	80	18	on	on	ADP
hjic-1161	80	19	the	the	DET
hjic-1161	80	20	quality	quality	NOUN
hjic-1161	80	21	of	of	ADP
hjic-1161	80	22	the	the	DET
hjic-1161	80	23	experimental	experimental	ADJ
hjic-1161	80	24	data	datum	NOUN
hjic-1161	80	25	50	50	NUM
hjic-1161	80	26	pp	pp	NOUN
hjic-1161	80	27	.	.	PUNCT
hjic-1161	81	1	45–55	45–55	NUM
hjic-1161	81	2	(	(	PUNCT
hjic-1161	81	3	2022	2022	NUM
hjic-1161	81	4	)	)	PUNCT
hjic-1161	81	5	50	50	NUM
hjic-1161	81	6	milčić	milčić	ADJ
hjic-1161	81	7	,	,	PUNCT
hjic-1161	81	8	ćevid	ćevid	PROPN
hjic-1161	81	9	,	,	PUNCT
hjic-1161	81	10	çakar	çakar	NOUN
hjic-1161	81	11	,	,	PUNCT
hjic-1161	81	12	sudar	sudar	ADJ
hjic-1161	81	13	and	and	CCONJ
hjic-1161	81	14	findrik	findrik	VERB
hjic-1161	81	15	blažević	blažević	PROPN
hjic-1161	82	1	(	(	PUNCT
hjic-1161	82	2	a	a	X
hjic-1161	82	3	)	)	PUNCT
hjic-1161	82	4	(	(	PUNCT
hjic-1161	82	5	b	b	X
hjic-1161	82	6	)	)	PUNCT
hjic-1161	82	7	(	(	PUNCT
hjic-1161	82	8	c	c	X
hjic-1161	82	9	)	)	PUNCT
hjic-1161	82	10	(	(	PUNCT
hjic-1161	82	11	d	d	X
hjic-1161	82	12	)	)	PUNCT
hjic-1161	82	13	figure	figure	NOUN
hjic-1161	82	14	5	5	NUM
hjic-1161	82	15	:	:	PUNCT
hjic-1161	82	16	estimation	estimation	NOUN
hjic-1161	82	17	of	of	ADP
hjic-1161	82	18	kinetic	kinetic	ADJ
hjic-1161	82	19	parameters	parameter	NOUN
hjic-1161	82	20	for	for	ADP
hjic-1161	82	21	a	a	DET
hjic-1161	82	22	two	two	NUM
hjic-1161	82	23	-	-	PUNCT
hjic-1161	82	24	substrate	substrate	NOUN
hjic-1161	82	25	reaction	reaction	NOUN
hjic-1161	82	26	by	by	ADP
hjic-1161	82	27	applying	apply	VERB
hjic-1161	82	28	linear	linear	NOUN
hjic-1161	82	29	(	(	PUNCT
hjic-1161	82	30	a	a	PRON
hjic-1161	82	31	and	and	CCONJ
hjic-1161	82	32	b	b	NOUN
hjic-1161	82	33	)	)	PUNCT
hjic-1161	82	34	and	and	CCONJ
hjic-1161	82	35	nonlinear	nonlinear	ADJ
hjic-1161	82	36	regression	regression	NOUN
hjic-1161	82	37	(	(	PUNCT
hjic-1161	82	38	c	c	NOUN
hjic-1161	82	39	and	and	CCONJ
hjic-1161	82	40	d	d	X
hjic-1161	82	41	)	)	PUNCT
hjic-1161	82	42	analyses	analysis	NOUN
hjic-1161	82	43	represents	represent	VERB
hjic-1161	82	44	linear	linear	ADJ
hjic-1161	82	45	data	datum	NOUN
hjic-1161	82	46	with	with	ADP
hjic-1161	82	47	a	a	DET
hjic-1161	82	48	relatively	relatively	ADV
hjic-1161	82	49	small	small	ADJ
hjic-1161	82	50	gradient	gradient	NOUN
hjic-1161	82	51	,	,	PUNCT
hjic-1161	82	52	indicating	indicate	VERB
hjic-1161	82	53	that	that	SCONJ
hjic-1161	82	54	the	the	DET
hjic-1161	82	55	measurements	measurement	NOUN
hjic-1161	82	56	were	be	AUX
hjic-1161	82	57	made	make	VERB
hjic-1161	82	58	properly	properly	ADV
hjic-1161	82	59	and	and	CCONJ
hjic-1161	82	60	the	the	DET
hjic-1161	82	61	dependence	dependence	NOUN
hjic-1161	82	62	is	be	AUX
hjic-1161	82	63	undoubtedly	undoubtedly	ADV
hjic-1161	82	64	linear	linear	ADJ
hjic-1161	82	65	within	within	ADP
hjic-1161	82	66	that	that	DET
hjic-1161	82	67	range	range	NOUN
hjic-1161	82	68	.	.	PUNCT
hjic-1161	83	1	a	a	DET
hjic-1161	83	2	series	series	NOUN
hjic-1161	83	3	of	of	ADP
hjic-1161	83	4	such	such	ADJ
hjic-1161	83	5	experiments	experiment	NOUN
hjic-1161	83	6	performed	perform	VERB
hjic-1161	83	7	at	at	ADP
hjic-1161	83	8	different	different	ADJ
hjic-1161	83	9	concentrations	concentration	NOUN
hjic-1161	83	10	of	of	ADP
hjic-1161	83	11	substrates	substrate	NOUN
hjic-1161	83	12	,	,	PUNCT
hjic-1161	83	13	products	product	NOUN
hjic-1161	83	14	and	and	CCONJ
hjic-1161	83	15	intermediates	intermediate	NOUN
hjic-1161	83	16	is	be	AUX
hjic-1161	83	17	required	require	VERB
hjic-1161	83	18	to	to	PART
hjic-1161	83	19	obtain	obtain	VERB
hjic-1161	83	20	one	one	NUM
hjic-1161	83	21	set	set	NOUN
hjic-1161	83	22	of	of	ADP
hjic-1161	83	23	experimental	experimental	ADJ
hjic-1161	83	24	data	datum	NOUN
hjic-1161	83	25	to	to	PART
hjic-1161	83	26	be	be	AUX
hjic-1161	83	27	subsequently	subsequently	ADV
hjic-1161	83	28	used	use	VERB
hjic-1161	83	29	for	for	ADP
hjic-1161	83	30	the	the	DET
hjic-1161	83	31	estimation	estimation	NOUN
hjic-1161	83	32	of	of	ADP
hjic-1161	83	33	kinetic	kinetic	ADJ
hjic-1161	83	34	parameters	parameter	NOUN
hjic-1161	83	35	.	.	PUNCT
hjic-1161	84	1	based	base	VERB
hjic-1161	84	2	on	on	ADP
hjic-1161	84	3	the	the	DET
hjic-1161	84	4	kinetic	kinetic	ADJ
hjic-1161	84	5	data	datum	NOUN
hjic-1161	84	6	,	,	PUNCT
hjic-1161	84	7	the	the	DET
hjic-1161	84	8	kinetic	kinetic	ADJ
hjic-1161	84	9	parameters	parameter	NOUN
hjic-1161	84	10	can	can	AUX
hjic-1161	84	11	be	be	AUX
hjic-1161	84	12	estimated	estimate	VERB
hjic-1161	84	13	by	by	ADP
hjic-1161	84	14	using	use	VERB
hjic-1161	84	15	nonlinear	nonlinear	ADJ
hjic-1161	84	16	regression	regression	NOUN
hjic-1161	84	17	analysis	analysis	NOUN
hjic-1161	84	18	,	,	PUNCT
hjic-1161	84	19	which	which	PRON
hjic-1161	84	20	is	be	AUX
hjic-1161	84	21	far	far	ADV
hjic-1161	84	22	better	well	ADJ
hjic-1161	84	23	than	than	ADP
hjic-1161	84	24	the	the	DET
hjic-1161	84	25	still	still	ADV
hjic-1161	84	26	commonly	commonly	ADV
hjic-1161	84	27	used	use	VERB
hjic-1161	84	28	linear	linear	PROPN
hjic-1161	84	29	regression	regression	NOUN
hjic-1161	84	30	analysis	analysis	NOUN
hjic-1161	84	31	[	[	X
hjic-1161	84	32	34	34	NUM
hjic-1161	84	33	]	]	PUNCT
hjic-1161	84	34	.	.	PUNCT
hjic-1161	85	1	this	this	PRON
hjic-1161	85	2	can	can	AUX
hjic-1161	85	3	be	be	AUX
hjic-1161	85	4	illustrated	illustrate	VERB
hjic-1161	85	5	by	by	ADP
hjic-1161	85	6	the	the	DET
hjic-1161	85	7	example	example	NOUN
hjic-1161	85	8	presented	present	VERB
hjic-1161	85	9	in	in	ADP
hjic-1161	85	10	fig	fig	NOUN
hjic-1161	85	11	.	.	PUNCT
hjic-1161	86	1	5	5	NUM
hjic-1161	86	2	whereby	whereby	SCONJ
hjic-1161	86	3	a	a	DET
hjic-1161	86	4	double	double	ADJ
hjic-1161	86	5	-	-	PUNCT
hjic-1161	86	6	substrate	substrate	NOUN
hjic-1161	86	7	reaction	reaction	NOUN
hjic-1161	86	8	was	be	AUX
hjic-1161	86	9	considered	consider	VERB
hjic-1161	86	10	and	and	CCONJ
hjic-1161	86	11	the	the	DET
hjic-1161	86	12	kinetic	kinetic	ADJ
hjic-1161	86	13	data	datum	NOUN
hjic-1161	86	14	concerning	concern	VERB
hjic-1161	86	15	the	the	DET
hjic-1161	86	16	dependence	dependence	NOUN
hjic-1161	86	17	of	of	ADP
hjic-1161	86	18	the	the	DET
hjic-1161	86	19	specific	specific	ADJ
hjic-1161	86	20	enzyme	enzyme	NOUN
hjic-1161	86	21	activity	activity	NOUN
hjic-1161	86	22	on	on	ADP
hjic-1161	86	23	the	the	DET
hjic-1161	86	24	concentration	concentration	NOUN
hjic-1161	86	25	of	of	ADP
hjic-1161	86	26	the	the	DET
hjic-1161	86	27	reactants	reactant	NOUN
hjic-1161	86	28	measured	measure	VERB
hjic-1161	86	29	.	.	PUNCT
hjic-1161	87	1	by	by	ADP
hjic-1161	87	2	measuring	measure	VERB
hjic-1161	87	3	the	the	DET
hjic-1161	87	4	initial	initial	ADJ
hjic-1161	87	5	reaction	reaction	NOUN
hjic-1161	87	6	rate	rate	NOUN
hjic-1161	87	7	(	(	PUNCT
hjic-1161	87	8	conversion	conversion	NOUN
hjic-1161	87	9	less	less	ADJ
hjic-1161	87	10	than	than	ADP
hjic-1161	87	11	10	10	NUM
hjic-1161	87	12	%	%	NOUN
hjic-1161	87	13	)	)	PUNCT
hjic-1161	87	14	,	,	PUNCT
hjic-1161	87	15	the	the	DET
hjic-1161	87	16	effect	effect	NOUN
hjic-1161	87	17	of	of	ADP
hjic-1161	87	18	product	product	NOUN
hjic-1161	87	19	inhibition	inhibition	NOUN
hjic-1161	87	20	or	or	CCONJ
hjic-1161	87	21	enzyme	enzyme	NOUN
hjic-1161	87	22	deactivation	deactivation	NOUN
hjic-1161	87	23	could	could	AUX
hjic-1161	87	24	be	be	AUX
hjic-1161	87	25	minimized	minimize	VERB
hjic-1161	87	26	[	[	X
hjic-1161	87	27	35	35	NUM
hjic-1161	87	28	]	]	PUNCT
hjic-1161	87	29	.	.	PUNCT
hjic-1161	88	1	this	this	DET
hjic-1161	88	2	example	example	NOUN
hjic-1161	88	3	will	will	AUX
hjic-1161	88	4	be	be	AUX
hjic-1161	88	5	used	use	VERB
hjic-1161	88	6	to	to	PART
hjic-1161	88	7	illustrate	illustrate	VERB
hjic-1161	88	8	the	the	DET
hjic-1161	88	9	differences	difference	NOUN
hjic-1161	88	10	between	between	ADP
hjic-1161	88	11	the	the	DET
hjic-1161	88	12	values	value	NOUN
hjic-1161	88	13	of	of	ADP
hjic-1161	88	14	the	the	DET
hjic-1161	88	15	estimated	estimate	VERB
hjic-1161	88	16	kinetic	kinetic	ADJ
hjic-1161	88	17	parameters	parameter	NOUN
hjic-1161	88	18	when	when	SCONJ
hjic-1161	88	19	various	various	ADJ
hjic-1161	88	20	methods	method	NOUN
hjic-1161	88	21	of	of	ADP
hjic-1161	88	22	estimation	estimation	NOUN
hjic-1161	88	23	are	be	AUX
hjic-1161	88	24	applied	apply	VERB
hjic-1161	88	25	.	.	PUNCT
hjic-1161	89	1	in	in	ADP
hjic-1161	89	2	the	the	DET
hjic-1161	89	3	first	first	ADJ
hjic-1161	89	4	case	case	NOUN
hjic-1161	89	5	,	,	PUNCT
hjic-1161	89	6	linear	linear	ADJ
hjic-1161	89	7	regression	regression	NOUN
hjic-1161	89	8	analysis	analysis	NOUN
hjic-1161	89	9	was	be	AUX
hjic-1161	89	10	applied	apply	VERB
hjic-1161	89	11	by	by	ADP
hjic-1161	89	12	using	use	VERB
hjic-1161	89	13	a	a	DET
hjic-1161	89	14	lineweaver	lineweaver	ADJ
hjic-1161	89	15	-	-	PUNCT
hjic-1161	89	16	burk	burk	NOUN
hjic-1161	89	17	plot	plot	NOUN
hjic-1161	89	18	(	(	PUNCT
hjic-1161	89	19	figs	fig	NOUN
hjic-1161	89	20	.	.	PUNCT
hjic-1161	89	21	5a-5b	5a-5b	NUM
hjic-1161	89	22	)	)	PUNCT
hjic-1161	89	23	.	.	PUNCT
hjic-1161	90	1	the	the	DET
hjic-1161	90	2	data	datum	NOUN
hjic-1161	90	3	show	show	VERB
hjic-1161	90	4	discrepancies	discrepancy	NOUN
hjic-1161	90	5	and	and	CCONJ
hjic-1161	90	6	,	,	PUNCT
hjic-1161	90	7	in	in	ADP
hjic-1161	90	8	the	the	DET
hjic-1161	90	9	case	case	NOUN
hjic-1161	90	10	of	of	ADP
hjic-1161	90	11	5b	5b	NUM
hjic-1161	90	12	,	,	PUNCT
hjic-1161	90	13	two	two	NUM
hjic-1161	90	14	points	point	NOUN
hjic-1161	90	15	needed	need	VERB
hjic-1161	90	16	to	to	PART
hjic-1161	90	17	be	be	AUX
hjic-1161	90	18	removed	remove	VERB
hjic-1161	90	19	from	from	ADP
hjic-1161	90	20	the	the	DET
hjic-1161	90	21	analysis	analysis	NOUN
hjic-1161	90	22	as	as	SCONJ
hjic-1161	90	23	they	they	PRON
hjic-1161	90	24	were	be	AUX
hjic-1161	90	25	outliers	outlier	NOUN
hjic-1161	90	26	.	.	PUNCT
hjic-1161	91	1	the	the	DET
hjic-1161	91	2	estimated	estimate	VERB
hjic-1161	91	3	kinetic	kinetic	ADJ
hjic-1161	91	4	parameters	parameter	NOUN
hjic-1161	91	5	are	be	AUX
hjic-1161	91	6	presented	present	VERB
hjic-1161	91	7	in	in	ADP
hjic-1161	91	8	table	table	NOUN
hjic-1161	91	9	1	1	NUM
hjic-1161	91	10	.	.	PUNCT
hjic-1161	92	1	in	in	ADP
hjic-1161	92	2	the	the	DET
hjic-1161	92	3	second	second	ADJ
hjic-1161	92	4	case	case	NOUN
hjic-1161	92	5	,	,	PUNCT
hjic-1161	92	6	the	the	DET
hjic-1161	92	7	kinetic	kinetic	ADJ
hjic-1161	92	8	parameters	parameter	NOUN
hjic-1161	92	9	were	be	AUX
hjic-1161	92	10	estimated	estimate	VERB
hjic-1161	92	11	by	by	ADP
hjic-1161	92	12	using	use	VERB
hjic-1161	92	13	singlesubstrate	singlesubstrate	NOUN
hjic-1161	92	14	michaelis	michaeli	NOUN
hjic-1161	92	15	-	-	PUNCT
hjic-1161	92	16	menten	menten	ADJ
hjic-1161	92	17	kinetics	kinetic	NOUN
hjic-1161	92	18	,	,	PUNCT
hjic-1161	92	19	which	which	PRON
hjic-1161	92	20	in	in	ADP
hjic-1161	92	21	all	all	DET
hjic-1161	92	22	likelihood	likelihood	NOUN
hjic-1161	92	23	is	be	AUX
hjic-1161	92	24	frequently	frequently	ADV
hjic-1161	92	25	used	use	VERB
hjic-1161	92	26	in	in	ADP
hjic-1161	92	27	practice	practice	NOUN
hjic-1161	92	28	.	.	PUNCT
hjic-1161	93	1	the	the	DET
hjic-1161	93	2	estimated	estimate	VERB
hjic-1161	93	3	kinetic	kinetic	ADJ
hjic-1161	93	4	parameters	parameter	NOUN
hjic-1161	93	5	presented	present	VERB
hjic-1161	93	6	in	in	ADP
hjic-1161	93	7	table	table	NOUN
hjic-1161	93	8	1	1	NUM
hjic-1161	93	9	are	be	AUX
hjic-1161	93	10	very	very	ADV
hjic-1161	93	11	different	different	ADJ
hjic-1161	93	12	from	from	ADP
hjic-1161	93	13	the	the	DET
hjic-1161	93	14	ones	one	NOUN
hjic-1161	93	15	obtained	obtain	VERB
hjic-1161	93	16	following	follow	VERB
hjic-1161	93	17	linear	linear	ADJ
hjic-1161	93	18	regression	regression	NOUN
hjic-1161	93	19	analysis	analysis	NOUN
hjic-1161	93	20	.	.	PUNCT
hjic-1161	94	1	furthermore	furthermore	ADV
hjic-1161	94	2	,	,	PUNCT
hjic-1161	94	3	since	since	SCONJ
hjic-1161	94	4	the	the	DET
hjic-1161	94	5	maximum	maximum	ADJ
hjic-1161	94	6	reaction	reaction	NOUN
hjic-1161	94	7	rates	rate	NOUN
hjic-1161	94	8	differ	differ	VERB
hjic-1161	94	9	for	for	ADP
hjic-1161	94	10	each	each	DET
hjic-1161	94	11	substrate	substrate	NOUN
hjic-1161	94	12	,	,	PUNCT
hjic-1161	94	13	the	the	DET
hjic-1161	94	14	measurements	measurement	NOUN
hjic-1161	94	15	in	in	ADP
hjic-1161	94	16	all	all	DET
hjic-1161	94	17	probability	probability	NOUN
hjic-1161	94	18	were	be	AUX
hjic-1161	94	19	not	not	PART
hjic-1161	94	20	made	make	VERB
hjic-1161	94	21	in	in	ADP
hjic-1161	94	22	the	the	DET
hjic-1161	94	23	area	area	NOUN
hjic-1161	94	24	of	of	ADP
hjic-1161	94	25	substrate	substrate	NOUN
hjic-1161	94	26	saturation	saturation	NOUN
hjic-1161	94	27	.	.	PUNCT
hjic-1161	95	1	michaelis	michaelis	PROPN
hjic-1161	95	2	constants	constant	NOUN
hjic-1161	95	3	estimated	estimate	VERB
hjic-1161	95	4	by	by	ADP
hjic-1161	95	5	using	use	VERB
hjic-1161	95	6	double	double	ADJ
hjic-1161	95	7	-	-	PUNCT
hjic-1161	95	8	substrate	substrate	NOUN
hjic-1161	95	9	michaelis	michaeli	NOUN
hjic-1161	95	10	-	-	PUNCT
hjic-1161	95	11	menten	menten	VERB
hjic-1161	95	12	kinetics	kinetic	NOUN
hjic-1161	95	13	strongly	strongly	ADV
hjic-1161	95	14	resemble	resemble	VERB
hjic-1161	95	15	the	the	DET
hjic-1161	95	16	values	value	NOUN
hjic-1161	95	17	estimated	estimate	VERB
hjic-1161	95	18	by	by	ADP
hjic-1161	95	19	using	use	VERB
hjic-1161	95	20	single	single	ADJ
hjic-1161	95	21	-	-	PUNCT
hjic-1161	95	22	substrate	substrate	NOUN
hjic-1161	95	23	michaelis	michaeli	NOUN
hjic-1161	95	24	-	-	PUNCT
hjic-1161	95	25	menten	menten	ADJ
hjic-1161	95	26	kinetics	kinetic	NOUN
hjic-1161	95	27	.	.	PUNCT
hjic-1161	96	1	however	however	ADV
hjic-1161	96	2	,	,	PUNCT
hjic-1161	96	3	when	when	SCONJ
hjic-1161	96	4	the	the	DET
hjic-1161	96	5	maximum	maximum	ADJ
hjic-1161	96	6	reaction	reaction	NOUN
hjic-1161	96	7	rates	rate	NOUN
hjic-1161	96	8	are	be	AUX
hjic-1161	96	9	compared	compare	VERB
hjic-1161	96	10	,	,	PUNCT
hjic-1161	96	11	a	a	DET
hjic-1161	96	12	significant	significant	ADJ
hjic-1161	96	13	discrepancy	discrepancy	NOUN
hjic-1161	96	14	between	between	ADP
hjic-1161	96	15	them	they	PRON
hjic-1161	96	16	can	can	AUX
hjic-1161	96	17	still	still	ADV
hjic-1161	96	18	be	be	AUX
hjic-1161	96	19	observed	observe	VERB
hjic-1161	96	20	.	.	PUNCT
hjic-1161	97	1	estimating	estimate	VERB
hjic-1161	97	2	the	the	DET
hjic-1161	97	3	maximum	maximum	ADJ
hjic-1161	97	4	reaction	reaction	NOUN
hjic-1161	97	5	rate	rate	NOUN
hjic-1161	97	6	by	by	ADP
hjic-1161	97	7	using	use	VERB
hjic-1161	97	8	double	double	ADJ
hjic-1161	97	9	-	-	PUNCT
hjic-1161	97	10	substrate	substrate	NOUN
hjic-1161	97	11	michaelis	michaeli	NOUN
hjic-1161	97	12	-	-	PUNCT
hjic-1161	97	13	menten	menten	ADJ
hjic-1161	97	14	kinetics	kinetic	NOUN
hjic-1161	97	15	is	be	AUX
hjic-1161	97	16	the	the	DET
hjic-1161	97	17	optimum	optimum	ADJ
hjic-1161	97	18	solution	solution	NOUN
hjic-1161	97	19	offering	offer	VERB
hjic-1161	97	20	a	a	DET
hjic-1161	97	21	unique	unique	ADJ
hjic-1161	97	22	value	value	NOUN
hjic-1161	97	23	of	of	ADP
hjic-1161	97	24	vm	vm	PROPN
hjic-1161	97	25	and	and	CCONJ
hjic-1161	97	26	taking	take	VERB
hjic-1161	97	27	into	into	ADP
hjic-1161	97	28	consideration	consideration	NOUN
hjic-1161	97	29	the	the	DET
hjic-1161	97	30	case	case	NOUN
hjic-1161	97	31	when	when	SCONJ
hjic-1161	97	32	the	the	DET
hjic-1161	97	33	non	non	ADJ
hjic-1161	97	34	-	-	ADJ
hjic-1161	97	35	varying	varying	ADJ
hjic-1161	97	36	substrate	substrate	NOUN
hjic-1161	97	37	was	be	AUX
hjic-1161	97	38	not	not	PART
hjic-1161	97	39	saturated	saturate	VERB
hjic-1161	97	40	.	.	PUNCT
hjic-1161	98	1	therefore	therefore	ADV
hjic-1161	98	2	,	,	PUNCT
hjic-1161	98	3	in	in	ADP
hjic-1161	98	4	the	the	DET
hjic-1161	98	5	case	case	NOUN
hjic-1161	98	6	when	when	SCONJ
hjic-1161	98	7	both	both	DET
hjic-1161	98	8	substrates	substrate	NOUN
hjic-1161	98	9	are	be	AUX
hjic-1161	98	10	saturated	saturate	VERB
hjic-1161	98	11	,	,	PUNCT
hjic-1161	98	12	single	single	ADJ
hjic-1161	98	13	-	-	PUNCT
hjic-1161	98	14	substrate	substrate	NOUN
hjic-1161	98	15	michaelismenten	michaelismenten	VERB
hjic-1161	98	16	kinetics	kinetic	NOUN
hjic-1161	98	17	and	and	CCONJ
hjic-1161	98	18	nonlinear	nonlinear	ADJ
hjic-1161	98	19	regression	regression	NOUN
hjic-1161	98	20	analysis	analysis	NOUN
hjic-1161	98	21	offer	offer	VERB
hjic-1161	98	22	a	a	DET
hjic-1161	98	23	suitable	suitable	ADJ
hjic-1161	98	24	solution	solution	NOUN
hjic-1161	98	25	to	to	PART
hjic-1161	98	26	estimate	estimate	VERB
hjic-1161	98	27	the	the	DET
hjic-1161	98	28	kinetic	kinetic	ADJ
hjic-1161	98	29	parameters	parameter	NOUN
hjic-1161	98	30	.	.	PUNCT
hjic-1161	99	1	4	4	X
hjic-1161	99	2	.	.	X
hjic-1161	99	3	investigation	investigation	NOUN
hjic-1161	99	4	of	of	ADP
hjic-1161	99	5	the	the	DET
hjic-1161	99	6	operational	operational	ADJ
hjic-1161	99	7	stability	stability	NOUN
hjic-1161	99	8	of	of	ADP
hjic-1161	99	9	the	the	DET
hjic-1161	99	10	enzyme	enzyme	NOUN
hjic-1161	99	11	enzyme	enzyme	NOUN
hjic-1161	99	12	activity	activity	NOUN
hjic-1161	99	13	inevitably	inevitably	ADV
hjic-1161	99	14	decreases	decrease	VERB
hjic-1161	99	15	in	in	ADP
hjic-1161	99	16	the	the	DET
hjic-1161	99	17	reactor	reactor	NOUN
hjic-1161	99	18	over	over	ADP
hjic-1161	99	19	time	time	NOUN
hjic-1161	99	20	,	,	PUNCT
hjic-1161	99	21	which	which	PRON
hjic-1161	99	22	means	mean	VERB
hjic-1161	99	23	that	that	SCONJ
hjic-1161	99	24	the	the	DET
hjic-1161	99	25	operational	operational	ADJ
hjic-1161	99	26	stability	stability	NOUN
hjic-1161	99	27	reduces	reduce	VERB
hjic-1161	99	28	as	as	ADV
hjic-1161	99	29	well	well	ADV
hjic-1161	99	30	[	[	X
hjic-1161	99	31	28–30	28–30	NOUN
hjic-1161	99	32	]	]	X
hjic-1161	99	33	.	.	PUNCT
hjic-1161	100	1	this	this	PRON
hjic-1161	100	2	also	also	ADV
hjic-1161	100	3	needs	need	VERB
hjic-1161	100	4	to	to	PART
hjic-1161	100	5	be	be	AUX
hjic-1161	100	6	quantified	quantify	VERB
hjic-1161	100	7	from	from	ADP
hjic-1161	100	8	the	the	DET
hjic-1161	100	9	hungarian	hungarian	ADJ
hjic-1161	100	10	journal	journal	NOUN
hjic-1161	100	11	of	of	ADP
hjic-1161	100	12	industry	industry	NOUN
hjic-1161	100	13	and	and	CCONJ
hjic-1161	100	14	chemistry	chemistry	NOUN
hjic-1161	100	15	enzyme	enzyme	NOUN
hjic-1161	100	16	reaction	reaction	NOUN
hjic-1161	100	17	engineering	engineering	NOUN
hjic-1161	100	18	as	as	ADP
hjic-1161	100	19	a	a	DET
hjic-1161	100	20	tool	tool	NOUN
hjic-1161	100	21	51	51	NUM
hjic-1161	100	22	parameter	parameter	NOUN
hjic-1161	100	23	linear	linear	PROPN
hjic-1161	100	24	regression	regression	NOUN
hjic-1161	100	25	analysis	analysis	NOUN
hjic-1161	100	26	1	1	NUM
hjic-1161	100	27	r	r	NOUN
hjic-1161	100	28	=	=	SYM
hjic-1161	100	29	1	1	NUM
hjic-1161	100	30	vm	vm	NOUN
hjic-1161	100	31	+	+	ADP
hjic-1161	100	32	km	km	PROPN
hjic-1161	100	33	vm	vm	PROPN
hjic-1161	100	34	1	1	NUM
hjic-1161	100	35	c	c	PROPN
hjic-1161	100	36	nonlinear	nonlinear	ADJ
hjic-1161	100	37	regression	regression	NOUN
hjic-1161	100	38	analysis	analysis	NOUN
hjic-1161	100	39	–	–	PUNCT
hjic-1161	100	40	single	single	ADJ
hjic-1161	100	41	-	-	PUNCT
hjic-1161	100	42	substrate	substrate	NOUN
hjic-1161	100	43	kinetics	kinetic	NOUN
hjic-1161	100	44	r	r	NOUN
hjic-1161	100	45	=	=	SYM
hjic-1161	100	46	vmc	vmc	PROPN
hjic-1161	100	47	km	km	NOUN
hjic-1161	100	48	+	+	CCONJ
hjic-1161	100	49	c	c	NOUN
hjic-1161	100	50	nonlinear	nonlinear	ADJ
hjic-1161	100	51	regression	regression	NOUN
hjic-1161	100	52	analysis	analysis	NOUN
hjic-1161	100	53	–	–	PUNCT
hjic-1161	100	54	double	double	ADJ
hjic-1161	100	55	-	-	PUNCT
hjic-1161	100	56	substrate	substrate	NOUN
hjic-1161	100	57	kinetics	kinetic	NOUN
hjic-1161	100	58	r	r	NOUN
hjic-1161	100	59	=	=	SYM
hjic-1161	100	60	vmc1c2	vmc1c2	PROPN
hjic-1161	100	61	(	(	PUNCT
hjic-1161	100	62	km1	km1	NOUN
hjic-1161	100	63	+	+	CCONJ
hjic-1161	100	64	c1	c1	PROPN
hjic-1161	100	65	)	)	PUNCT
hjic-1161	100	66	(	(	PUNCT
hjic-1161	100	67	km2	km2	PROPN
hjic-1161	100	68	+	+	CCONJ
hjic-1161	100	69	c2	c2	PROPN
hjic-1161	100	70	)	)	PUNCT
hjic-1161	100	71	vm	vm	NOUN
hjic-1161	101	1	[	[	X
hjic-1161	101	2	u	u	X
hjic-1161	101	3	/	/	SYM
hjic-1161	101	4	mg	mg	PROPN
hjic-1161	101	5	]	]	PUNCT
hjic-1161	101	6	0.743	0.743	NUM
hjic-1161	101	7	(	(	PUNCT
hjic-1161	101	8	3.539	3.539	NUM
hjic-1161	101	9	)	)	PUNCT
hjic-1161	101	10	1.448	1.448	NUM
hjic-1161	101	11	(	(	PUNCT
hjic-1161	101	12	2.119	2.119	NUM
hjic-1161	101	13	)	)	PUNCT
hjic-1161	101	14	4.177	4.177	NUM
hjic-1161	101	15	km1	km1	NOUN
hjic-1161	102	1	[	[	X
hjic-1161	102	2	mmol	mmol	NOUN
hjic-1161	102	3	/	/	SYM
hjic-1161	102	4	dm3	dm3	NOUN
hjic-1161	102	5	]	]	X
hjic-1161	102	6	2.56	2.56	NUM
hjic-1161	102	7	8.2	8.2	NUM
hjic-1161	102	8	9.09	9.09	NUM
hjic-1161	102	9	km2	km2	NOUN
hjic-1161	103	1	[	[	X
hjic-1161	103	2	mmol	mmol	NOUN
hjic-1161	103	3	/	/	SYM
hjic-1161	103	4	dm3	dm3	NOUN
hjic-1161	103	5	]	]	X
hjic-1161	103	6	46.366	46.366	NUM
hjic-1161	103	7	7.726	7.726	NUM
hjic-1161	103	8	9.191	9.191	NUM
hjic-1161	103	9	table	table	NOUN
hjic-1161	103	10	1	1	NUM
hjic-1161	103	11	:	:	PUNCT
hjic-1161	103	12	comparison	comparison	NOUN
hjic-1161	103	13	between	between	ADP
hjic-1161	103	14	different	different	ADJ
hjic-1161	103	15	methods	method	NOUN
hjic-1161	103	16	to	to	PART
hjic-1161	103	17	estimate	estimate	VERB
hjic-1161	103	18	the	the	DET
hjic-1161	103	19	values	value	NOUN
hjic-1161	103	20	of	of	ADP
hjic-1161	103	21	kinetic	kinetic	ADJ
hjic-1161	103	22	parameters	parameter	NOUN
hjic-1161	103	23	in	in	ADP
hjic-1161	103	24	an	an	DET
hjic-1161	103	25	enzymatic	enzymatic	ADJ
hjic-1161	103	26	reaction	reaction	NOUN
hjic-1161	103	27	experimental	experimental	ADJ
hjic-1161	103	28	data	datum	NOUN
hjic-1161	103	29	[	[	X
hjic-1161	103	30	29	29	NUM
hjic-1161	103	31	]	]	PUNCT
hjic-1161	103	32	and	and	CCONJ
hjic-1161	103	33	incorporated	incorporate	VERB
hjic-1161	103	34	into	into	ADP
hjic-1161	103	35	the	the	DET
hjic-1161	103	36	kinetic	kinetic	ADJ
hjic-1161	103	37	model	model	NOUN
hjic-1161	103	38	.	.	PUNCT
hjic-1161	104	1	in	in	ADP
hjic-1161	104	2	many	many	ADJ
hjic-1161	104	3	cases	case	NOUN
hjic-1161	104	4	,	,	PUNCT
hjic-1161	104	5	the	the	DET
hjic-1161	104	6	enzyme	enzyme	NOUN
hjic-1161	104	7	activity	activity	NOUN
hjic-1161	104	8	can	can	AUX
hjic-1161	104	9	be	be	AUX
hjic-1161	104	10	followed	follow	VERB
hjic-1161	104	11	by	by	ADP
hjic-1161	104	12	an	an	DET
hjic-1161	104	13	independent	independent	ADJ
hjic-1161	104	14	enzyme	enzyme	NOUN
hjic-1161	104	15	assay	assay	VERB
hjic-1161	104	16	.	.	PUNCT
hjic-1161	105	1	in	in	ADP
hjic-1161	105	2	other	other	ADJ
hjic-1161	105	3	cases	case	NOUN
hjic-1161	105	4	,	,	PUNCT
hjic-1161	105	5	it	it	PRON
hjic-1161	105	6	can	can	AUX
hjic-1161	105	7	be	be	AUX
hjic-1161	105	8	estimated	estimate	VERB
hjic-1161	105	9	by	by	ADP
hjic-1161	105	10	using	use	VERB
hjic-1161	105	11	the	the	DET
hjic-1161	105	12	kinetic	kinetic	ADJ
hjic-1161	105	13	model	model	NOUN
hjic-1161	105	14	and	and	CCONJ
hjic-1161	105	15	other	other	ADJ
hjic-1161	105	16	experiments	experiment	NOUN
hjic-1161	105	17	.	.	PUNCT
hjic-1161	106	1	the	the	DET
hjic-1161	106	2	operational	operational	ADJ
hjic-1161	106	3	stability	stability	NOUN
hjic-1161	106	4	of	of	ADP
hjic-1161	106	5	enzymes	enzyme	NOUN
hjic-1161	106	6	is	be	AUX
hjic-1161	106	7	an	an	DET
hjic-1161	106	8	important	important	ADJ
hjic-1161	106	9	topic	topic	NOUN
hjic-1161	106	10	not	not	PART
hjic-1161	106	11	only	only	ADV
hjic-1161	106	12	in	in	ADP
hjic-1161	106	13	terms	term	NOUN
hjic-1161	106	14	of	of	ADP
hjic-1161	106	15	research	research	NOUN
hjic-1161	106	16	but	but	CCONJ
hjic-1161	106	17	also	also	ADV
hjic-1161	106	18	with	with	ADP
hjic-1161	106	19	regard	regard	NOUN
hjic-1161	106	20	to	to	ADP
hjic-1161	106	21	their	their	PRON
hjic-1161	106	22	applications	application	NOUN
hjic-1161	106	23	.	.	PUNCT
hjic-1161	107	1	understanding	understanding	NOUN
hjic-1161	107	2	and	and	CCONJ
hjic-1161	107	3	describing	describe	VERB
hjic-1161	107	4	quantitatively	quantitatively	ADV
hjic-1161	107	5	as	as	ADV
hjic-1161	107	6	well	well	ADV
hjic-1161	107	7	as	as	ADP
hjic-1161	107	8	qualitatively	qualitatively	ADV
hjic-1161	107	9	how	how	SCONJ
hjic-1161	107	10	enzyme	enzyme	NOUN
hjic-1161	107	11	function	function	NOUN
hjic-1161	107	12	and	and	CCONJ
hjic-1161	107	13	structure	structure	NOUN
hjic-1161	107	14	change	change	NOUN
hjic-1161	107	15	during	during	ADP
hjic-1161	107	16	conversion	conversion	NOUN
hjic-1161	107	17	in	in	ADP
hjic-1161	107	18	a	a	DET
hjic-1161	107	19	bioreactor	bioreactor	NOUN
hjic-1161	107	20	is	be	AUX
hjic-1161	107	21	of	of	ADP
hjic-1161	107	22	crucial	crucial	ADJ
hjic-1161	107	23	importance	importance	NOUN
hjic-1161	107	24	[	[	X
hjic-1161	107	25	28	28	NUM
hjic-1161	107	26	,	,	PUNCT
hjic-1161	107	27	36	36	NUM
hjic-1161	107	28	]	]	PUNCT
hjic-1161	107	29	.	.	PUNCT
hjic-1161	108	1	in	in	ADP
hjic-1161	108	2	their	their	PRON
hjic-1161	108	3	work	work	NOUN
hjic-1161	108	4	,	,	PUNCT
hjic-1161	108	5	börner	börner	PROPN
hjic-1161	108	6	et	et	PROPN
hjic-1161	108	7	al	al	PROPN
hjic-1161	108	8	.	.	PROPN
hjic-1161	108	9	investigated	investigate	VERB
hjic-1161	108	10	the	the	DET
hjic-1161	108	11	mechanistic	mechanistic	ADJ
hjic-1161	108	12	reasons	reason	NOUN
hjic-1161	108	13	for	for	ADP
hjic-1161	108	14	the	the	DET
hjic-1161	108	15	poor	poor	ADJ
hjic-1161	108	16	operational	operational	ADJ
hjic-1161	108	17	stability	stability	NOUN
hjic-1161	108	18	of	of	ADP
hjic-1161	108	19	amine	amine	ADJ
hjic-1161	108	20	transaminases	transaminase	NOUN
hjic-1161	108	21	along	along	ADP
hjic-1161	108	22	with	with	ADP
hjic-1161	108	23	the	the	DET
hjic-1161	108	24	influence	influence	NOUN
hjic-1161	108	25	of	of	ADP
hjic-1161	108	26	quaternary	quaternary	ADJ
hjic-1161	108	27	structure	structure	NOUN
hjic-1161	108	28	,	,	PUNCT
hjic-1161	108	29	cofactors	cofactor	NOUN
hjic-1161	108	30	and	and	CCONJ
hjic-1161	108	31	substrates	substrate	NOUN
hjic-1161	108	32	.	.	PUNCT
hjic-1161	109	1	through	through	ADP
hjic-1161	109	2	their	their	PRON
hjic-1161	109	3	kinetic	kinetic	ADJ
hjic-1161	109	4	and	and	CCONJ
hjic-1161	109	5	thermodynamic	thermodynamic	ADJ
hjic-1161	109	6	experiments	experiment	NOUN
hjic-1161	109	7	,	,	PUNCT
hjic-1161	109	8	they	they	PRON
hjic-1161	109	9	were	be	AUX
hjic-1161	109	10	able	able	ADJ
hjic-1161	109	11	to	to	PART
hjic-1161	109	12	identify	identify	VERB
hjic-1161	109	13	the	the	DET
hjic-1161	109	14	structural	structural	ADJ
hjic-1161	109	15	domain	domain	NOUN
hjic-1161	109	16	that	that	PRON
hjic-1161	109	17	appears	appear	VERB
hjic-1161	109	18	to	to	PART
hjic-1161	109	19	confer	confer	VERB
hjic-1161	109	20	stability	stability	NOUN
hjic-1161	109	21	.	.	PUNCT
hjic-1161	110	1	the	the	DET
hjic-1161	110	2	study	study	NOUN
hjic-1161	110	3	revealed	reveal	VERB
hjic-1161	110	4	that	that	SCONJ
hjic-1161	110	5	the	the	DET
hjic-1161	110	6	enzyme	enzyme	NOUN
hjic-1161	110	7	is	be	AUX
hjic-1161	110	8	significantly	significantly	ADV
hjic-1161	110	9	more	more	ADV
hjic-1161	110	10	stable	stable	ADJ
hjic-1161	110	11	when	when	SCONJ
hjic-1161	110	12	at	at	ADP
hjic-1161	110	13	rest	rest	NOUN
hjic-1161	110	14	than	than	ADP
hjic-1161	110	15	in	in	ADP
hjic-1161	110	16	its	its	PRON
hjic-1161	110	17	operational	operational	ADJ
hjic-1161	110	18	state	state	NOUN
hjic-1161	110	19	,	,	PUNCT
hjic-1161	110	20	moreover	moreover	ADV
hjic-1161	110	21	,	,	PUNCT
hjic-1161	110	22	its	its	PRON
hjic-1161	110	23	operational	operational	ADJ
hjic-1161	110	24	stability	stability	NOUN
hjic-1161	110	25	was	be	AUX
hjic-1161	110	26	lower	low	ADJ
hjic-1161	110	27	and	and	CCONJ
hjic-1161	110	28	experiments	experiment	NOUN
hjic-1161	110	29	suggested	suggest	VERB
hjic-1161	110	30	a	a	DET
hjic-1161	110	31	mechanism	mechanism	NOUN
hjic-1161	110	32	that	that	PRON
hjic-1161	110	33	brought	bring	VERB
hjic-1161	110	34	about	about	ADP
hjic-1161	110	35	substrate	substrate	NOUN
hjic-1161	110	36	-	-	PUNCT
hjic-1161	110	37	induced	induce	VERB
hjic-1161	110	38	deactivation	deactivation	NOUN
hjic-1161	110	39	[	[	X
hjic-1161	110	40	28	28	NUM
hjic-1161	110	41	]	]	PUNCT
hjic-1161	110	42	.	.	PUNCT
hjic-1161	111	1	in	in	ADP
hjic-1161	111	2	many	many	ADJ
hjic-1161	111	3	reports	report	NOUN
hjic-1161	111	4	to	to	ADP
hjic-1161	111	5	date	date	NOUN
hjic-1161	111	6	,	,	PUNCT
hjic-1161	111	7	it	it	PRON
hjic-1161	111	8	has	have	AUX
hjic-1161	111	9	been	be	AUX
hjic-1161	111	10	stated	state	VERB
hjic-1161	111	11	that	that	SCONJ
hjic-1161	111	12	the	the	DET
hjic-1161	111	13	presence	presence	NOUN
hjic-1161	111	14	of	of	ADP
hjic-1161	111	15	substrates	substrate	NOUN
hjic-1161	111	16	and	and	CCONJ
hjic-1161	111	17	their	their	PRON
hjic-1161	111	18	concentrations	concentration	NOUN
hjic-1161	111	19	can	can	AUX
hjic-1161	111	20	have	have	VERB
hjic-1161	111	21	both	both	CCONJ
hjic-1161	111	22	positive	positive	ADJ
hjic-1161	111	23	[	[	X
hjic-1161	111	24	37	37	NUM
hjic-1161	111	25	]	]	PUNCT
hjic-1161	111	26	and	and	CCONJ
hjic-1161	111	27	negative	negative	ADJ
hjic-1161	111	28	[	[	X
hjic-1161	111	29	30	30	NUM
hjic-1161	111	30	]	]	PUNCT
hjic-1161	111	31	effects	effect	NOUN
hjic-1161	111	32	on	on	ADP
hjic-1161	111	33	enzyme	enzyme	NOUN
hjic-1161	111	34	stability	stability	NOUN
hjic-1161	111	35	.	.	PUNCT
hjic-1161	112	1	in	in	ADP
hjic-1161	112	2	a	a	DET
hjic-1161	112	3	study	study	NOUN
hjic-1161	112	4	by	by	ADP
hjic-1161	112	5	česnik	česnik	PROPN
hjic-1161	112	6	et	et	PROPN
hjic-1161	112	7	al	al	PROPN
hjic-1161	112	8	.	.	PUNCT
hjic-1161	113	1	[	[	X
hjic-1161	113	2	30	30	NUM
hjic-1161	113	3	]	]	PUNCT
hjic-1161	113	4	,	,	PUNCT
hjic-1161	113	5	formaldehyde	formaldehyde	NOUN
hjic-1161	113	6	as	as	ADP
hjic-1161	113	7	a	a	DET
hjic-1161	113	8	substrate	substrate	NOUN
hjic-1161	113	9	was	be	AUX
hjic-1161	113	10	found	find	VERB
hjic-1161	113	11	to	to	PART
hjic-1161	113	12	have	have	VERB
hjic-1161	113	13	a	a	DET
hjic-1161	113	14	negative	negative	ADJ
hjic-1161	113	15	effect	effect	NOUN
hjic-1161	113	16	on	on	ADP
hjic-1161	113	17	enzyme	enzyme	NOUN
hjic-1161	113	18	activity	activity	NOUN
hjic-1161	113	19	during	during	ADP
hjic-1161	113	20	experiments	experiment	NOUN
hjic-1161	113	21	(	(	PUNCT
hjic-1161	113	22	fig	fig	NOUN
hjic-1161	113	23	.	.	PUNCT
hjic-1161	113	24	6a	6a	NOUN
hjic-1161	113	25	)	)	PUNCT
hjic-1161	113	26	.	.	PUNCT
hjic-1161	114	1	subsequently	subsequently	ADV
hjic-1161	114	2	,	,	PUNCT
hjic-1161	114	3	it	it	PRON
hjic-1161	114	4	was	be	AUX
hjic-1161	114	5	found	find	VERB
hjic-1161	114	6	that	that	SCONJ
hjic-1161	114	7	this	this	PRON
hjic-1161	114	8	could	could	AUX
hjic-1161	114	9	be	be	AUX
hjic-1161	114	10	correlated	correlate	VERB
hjic-1161	114	11	with	with	ADP
hjic-1161	114	12	the	the	DET
hjic-1161	114	13	operational	operational	ADJ
hjic-1161	114	14	stability	stability	NOUN
hjic-1161	114	15	of	of	ADP
hjic-1161	114	16	the	the	DET
hjic-1161	114	17	enzyme	enzyme	NOUN
hjic-1161	114	18	(	(	PUNCT
hjic-1161	114	19	fig	fig	NOUN
hjic-1161	114	20	.	.	PUNCT
hjic-1161	114	21	6b	6b	NUM
hjic-1161	114	22	)	)	PUNCT
hjic-1161	114	23	.	.	PUNCT
hjic-1161	115	1	considering	consider	VERB
hjic-1161	115	2	the	the	DET
hjic-1161	115	3	reactivity	reactivity	NOUN
hjic-1161	115	4	of	of	ADP
hjic-1161	115	5	formaldehyde	formaldehyde	NOUN
hjic-1161	115	6	and	and	CCONJ
hjic-1161	115	7	the	the	DET
hjic-1161	115	8	size	size	NOUN
hjic-1161	115	9	of	of	ADP
hjic-1161	115	10	this	this	DET
hjic-1161	115	11	molecule	molecule	NOUN
hjic-1161	115	12	,	,	PUNCT
hjic-1161	115	13	chemical	chemical	ADJ
hjic-1161	115	14	damage	damage	NOUN
hjic-1161	115	15	to	to	ADP
hjic-1161	115	16	the	the	DET
hjic-1161	115	17	protein	protein	NOUN
hjic-1161	115	18	may	may	AUX
hjic-1161	115	19	occur	occur	VERB
hjic-1161	115	20	in	in	ADP
hjic-1161	115	21	its	its	PRON
hjic-1161	115	22	presence	presence	NOUN
hjic-1161	115	23	,	,	PUNCT
hjic-1161	115	24	as	as	SCONJ
hjic-1161	115	25	reported	report	VERB
hjic-1161	115	26	in	in	ADP
hjic-1161	115	27	other	other	ADJ
hjic-1161	115	28	studies	study	NOUN
hjic-1161	115	29	.	.	PUNCT
hjic-1161	116	1	in	in	ADP
hjic-1161	116	2	a	a	DET
hjic-1161	116	3	study	study	NOUN
hjic-1161	116	4	involving	involve	VERB
hjic-1161	116	5	the	the	DET
hjic-1161	116	6	dehalogenation	dehalogenation	NOUN
hjic-1161	116	7	of	of	ADP
hjic-1161	116	8	1,3	1,3	NUM
hjic-1161	116	9	-	-	PUNCT
hjic-1161	116	10	dichloro2	dichloro2	NOUN
hjic-1161	116	11	-	-	PUNCT
hjic-1161	116	12	propanol	propanol	NOUN
hjic-1161	116	13	(	(	PUNCT
hjic-1161	116	14	1,3	1,3	NUM
hjic-1161	116	15	-	-	PUNCT
hjic-1161	116	16	dcp	dcp	NOUN
hjic-1161	116	17	)	)	PUNCT
hjic-1161	116	18	catalysed	catalyse	VERB
hjic-1161	116	19	by	by	ADP
hjic-1161	116	20	halohydrin	halohydrin	NOUN
hjic-1161	116	21	dehalogenases	dehalogenase	NOUN
hjic-1161	116	22	(	(	PUNCT
hjic-1161	116	23	hhdhs	hhdhs	PROPN
hjic-1161	116	24	)	)	PUNCT
hjic-1161	116	25	,	,	PUNCT
hjic-1161	116	26	it	it	PRON
hjic-1161	116	27	was	be	AUX
hjic-1161	116	28	found	find	VERB
hjic-1161	116	29	that	that	SCONJ
hjic-1161	116	30	the	the	DET
hjic-1161	116	31	substrate	substrate	NOUN
hjic-1161	116	32	1,3	1,3	NUM
hjic-1161	116	33	-	-	PUNCT
hjic-1161	116	34	dcp	dcp	NOUN
hjic-1161	116	35	causes	cause	VERB
hjic-1161	116	36	enzyme	enzyme	NOUN
hjic-1161	116	37	deactivation	deactivation	NOUN
hjic-1161	116	38	during	during	ADP
hjic-1161	116	39	incubation	incubation	NOUN
hjic-1161	116	40	,	,	PUNCT
hjic-1161	116	41	moreover	moreover	ADV
hjic-1161	116	42	,	,	PUNCT
hjic-1161	116	43	as	as	SCONJ
hjic-1161	116	44	observed	observe	VERB
hjic-1161	116	45	in	in	ADP
hjic-1161	116	46	the	the	DET
hjic-1161	116	47	previously	previously	ADV
hjic-1161	116	48	described	describe	VERB
hjic-1161	116	49	case	case	NOUN
hjic-1161	116	50	,	,	PUNCT
hjic-1161	116	51	the	the	DET
hjic-1161	116	52	substrate	substrate	NOUN
hjic-1161	116	53	concentration	concentration	NOUN
hjic-1161	116	54	has	have	VERB
hjic-1161	116	55	a	a	DET
hjic-1161	116	56	significant	significant	ADJ
hjic-1161	116	57	effect	effect	NOUN
hjic-1161	116	58	on	on	ADP
hjic-1161	116	59	enzyme	enzyme	NOUN
hjic-1161	116	60	activity	activity	NOUN
hjic-1161	116	61	(	(	PUNCT
hjic-1161	116	62	unpublished	unpublished	ADJ
hjic-1161	116	63	data	datum	NOUN
hjic-1161	116	64	,	,	PUNCT
hjic-1161	116	65	fig	fig	NOUN
hjic-1161	116	66	.	.	PUNCT
hjic-1161	117	1	6c	6c	NUM
hjic-1161	117	2	)	)	PUNCT
hjic-1161	117	3	.	.	PUNCT
hjic-1161	118	1	experiments	experiment	NOUN
hjic-1161	118	2	conducted	conduct	VERB
hjic-1161	118	3	in	in	ADP
hjic-1161	118	4	batch	batch	NOUN
hjic-1161	118	5	reactors	reactor	NOUN
hjic-1161	118	6	corroborated	corroborate	VERB
hjic-1161	118	7	that	that	SCONJ
hjic-1161	118	8	the	the	DET
hjic-1161	118	9	operational	operational	ADJ
hjic-1161	118	10	stability	stability	NOUN
hjic-1161	118	11	decay	decay	NOUN
hjic-1161	118	12	rate	rate	NOUN
hjic-1161	118	13	constant	constant	ADJ
hjic-1161	118	14	can	can	AUX
hjic-1161	118	15	be	be	AUX
hjic-1161	118	16	directly	directly	ADV
hjic-1161	118	17	correlated	correlate	VERB
hjic-1161	118	18	to	to	ADP
hjic-1161	118	19	the	the	DET
hjic-1161	118	20	substrate	substrate	NOUN
hjic-1161	118	21	concentration	concentration	NOUN
hjic-1161	118	22	(	(	PUNCT
hjic-1161	118	23	unpublished	unpublished	ADJ
hjic-1161	118	24	data	datum	NOUN
hjic-1161	118	25	,	,	PUNCT
hjic-1161	118	26	fig	fig	NOUN
hjic-1161	118	27	.	.	PUNCT
hjic-1161	119	1	6d	6d	NUM
hjic-1161	119	2	)	)	PUNCT
hjic-1161	119	3	.	.	PUNCT
hjic-1161	120	1	these	these	PRON
hjic-1161	120	2	are	be	AUX
hjic-1161	120	3	not	not	PART
hjic-1161	120	4	the	the	DET
hjic-1161	120	5	only	only	ADJ
hjic-1161	120	6	examples	example	NOUN
hjic-1161	120	7	of	of	ADP
hjic-1161	120	8	this	this	DET
hjic-1161	120	9	behaviour	behaviour	NOUN
hjic-1161	120	10	.	.	PUNCT
hjic-1161	121	1	in	in	ADP
hjic-1161	121	2	a	a	DET
hjic-1161	121	3	study	study	NOUN
hjic-1161	121	4	by	by	ADP
hjic-1161	121	5	vasić-rački	vasić-rački	NOUN
hjic-1161	121	6	et	et	PROPN
hjic-1161	121	7	al	al	PROPN
hjic-1161	121	8	.	.	PROPN
hjic-1161	121	9	,	,	PUNCT
hjic-1161	121	10	it	it	PRON
hjic-1161	121	11	was	be	AUX
hjic-1161	121	12	also	also	ADV
hjic-1161	121	13	shown	show	VERB
hjic-1161	121	14	that	that	SCONJ
hjic-1161	121	15	glycolaldehyde	glycolaldehyde	PROPN
hjic-1161	121	16	caused	cause	VERB
hjic-1161	121	17	operational	operational	ADJ
hjic-1161	121	18	stability	stability	NOUN
hjic-1161	121	19	decay	decay	NOUN
hjic-1161	121	20	in	in	ADP
hjic-1161	121	21	the	the	DET
hjic-1161	121	22	reactor	reactor	NOUN
hjic-1161	121	23	,	,	PUNCT
hjic-1161	121	24	the	the	DET
hjic-1161	121	25	rate	rate	NOUN
hjic-1161	121	26	of	of	ADP
hjic-1161	121	27	which	which	PRON
hjic-1161	121	28	was	be	AUX
hjic-1161	121	29	dependent	dependent	ADJ
hjic-1161	121	30	on	on	ADP
hjic-1161	121	31	its	its	PRON
hjic-1161	121	32	concentration	concentration	NOUN
hjic-1161	122	1	[	[	X
hjic-1161	122	2	38	38	NUM
hjic-1161	122	3	]	]	PUNCT
hjic-1161	122	4	.	.	PUNCT
hjic-1161	123	1	in	in	ADP
hjic-1161	123	2	all	all	PRON
hjic-1161	123	3	of	of	ADP
hjic-1161	123	4	these	these	DET
hjic-1161	123	5	cases	case	NOUN
hjic-1161	123	6	,	,	PUNCT
hjic-1161	123	7	the	the	DET
hjic-1161	123	8	quantification	quantification	NOUN
hjic-1161	123	9	of	of	ADP
hjic-1161	123	10	the	the	DET
hjic-1161	123	11	operational	operational	ADJ
hjic-1161	123	12	stability	stability	NOUN
hjic-1161	123	13	decay	decay	NOUN
hjic-1161	123	14	rate	rate	NOUN
hjic-1161	123	15	constant	constant	ADJ
hjic-1161	123	16	and	and	CCONJ
hjic-1161	123	17	the	the	DET
hjic-1161	123	18	modelling	modelling	NOUN
hjic-1161	123	19	approach	approach	NOUN
hjic-1161	123	20	improved	improve	VERB
hjic-1161	123	21	the	the	DET
hjic-1161	123	22	outcome	outcome	NOUN
hjic-1161	123	23	of	of	ADP
hjic-1161	123	24	the	the	DET
hjic-1161	123	25	reaction	reaction	NOUN
hjic-1161	123	26	and	and	CCONJ
hjic-1161	123	27	increased	increase	VERB
hjic-1161	123	28	process	process	NOUN
hjic-1161	123	29	metrics	metric	NOUN
hjic-1161	123	30	values	value	NOUN
hjic-1161	123	31	.	.	PUNCT
hjic-1161	124	1	another	another	DET
hjic-1161	124	2	example	example	NOUN
hjic-1161	124	3	of	of	ADP
hjic-1161	124	4	the	the	DET
hjic-1161	124	5	effect	effect	NOUN
hjic-1161	124	6	of	of	ADP
hjic-1161	124	7	a	a	DET
hjic-1161	124	8	substrate	substrate	NOUN
hjic-1161	124	9	on	on	ADP
hjic-1161	124	10	enzyme	enzyme	NOUN
hjic-1161	124	11	activity	activity	NOUN
hjic-1161	124	12	can	can	AUX
hjic-1161	124	13	be	be	AUX
hjic-1161	124	14	demonstrated	demonstrate	VERB
hjic-1161	124	15	by	by	ADP
hjic-1161	124	16	different	different	ADJ
hjic-1161	124	17	oxidases	oxidase	NOUN
hjic-1161	124	18	.	.	PUNCT
hjic-1161	125	1	in	in	ADP
hjic-1161	125	2	one	one	NUM
hjic-1161	125	3	study	study	NOUN
hjic-1161	125	4	,	,	PUNCT
hjic-1161	125	5	the	the	DET
hjic-1161	125	6	operational	operational	ADJ
hjic-1161	125	7	stability	stability	NOUN
hjic-1161	125	8	of	of	ADP
hjic-1161	125	9	d	d	ADJ
hjic-1161	125	10	-	-	ADJ
hjic-1161	125	11	amino	amino	ADJ
hjic-1161	125	12	acid	acid	NOUN
hjic-1161	125	13	oxidase	oxidase	NOUN
hjic-1161	125	14	was	be	AUX
hjic-1161	125	15	investigated	investigate	VERB
hjic-1161	125	16	in	in	ADP
hjic-1161	125	17	the	the	DET
hjic-1161	125	18	presence	presence	NOUN
hjic-1161	125	19	and	and	CCONJ
hjic-1161	125	20	absence	absence	NOUN
hjic-1161	125	21	of	of	ADP
hjic-1161	125	22	aeration	aeration	NOUN
hjic-1161	125	23	[	[	X
hjic-1161	125	24	40	40	NUM
hjic-1161	125	25	]	]	PUNCT
hjic-1161	125	26	.	.	PUNCT
hjic-1161	126	1	the	the	DET
hjic-1161	126	2	enzyme	enzyme	NOUN
hjic-1161	126	3	operational	operational	ADJ
hjic-1161	126	4	stability	stability	NOUN
hjic-1161	126	5	decay	decay	NOUN
hjic-1161	126	6	rate	rate	NOUN
hjic-1161	126	7	of	of	ADP
hjic-1161	126	8	d	d	ADJ
hjic-1161	126	9	-	-	ADJ
hjic-1161	126	10	amino	amino	ADJ
hjic-1161	126	11	acid	acid	NOUN
hjic-1161	126	12	oxidase	oxidase	NOUN
hjic-1161	126	13	from	from	ADP
hjic-1161	126	14	porcine	porcine	NOUN
hjic-1161	126	15	kidneys	kidney	NOUN
hjic-1161	126	16	was	be	AUX
hjic-1161	126	17	reduced	reduce	VERB
hjic-1161	126	18	by	by	ADP
hjic-1161	126	19	increasing	increase	VERB
hjic-1161	126	20	the	the	DET
hjic-1161	126	21	oxygen	oxygen	NOUN
hjic-1161	126	22	concentration	concentration	NOUN
hjic-1161	126	23	in	in	ADP
hjic-1161	126	24	the	the	DET
hjic-1161	126	25	reaction	reaction	NOUN
hjic-1161	126	26	solution	solution	NOUN
hjic-1161	126	27	and	and	CCONJ
hjic-1161	126	28	the	the	DET
hjic-1161	126	29	enzyme	enzyme	NOUN
hjic-1161	126	30	activity	activity	NOUN
hjic-1161	126	31	decreased	decrease	VERB
hjic-1161	126	32	more	more	ADV
hjic-1161	126	33	rapidly	rapidly	ADV
hjic-1161	126	34	.	.	PUNCT
hjic-1161	127	1	similar	similar	ADJ
hjic-1161	127	2	conclusions	conclusion	NOUN
hjic-1161	127	3	were	be	AUX
hjic-1161	127	4	drawn	draw	VERB
hjic-1161	127	5	in	in	ADP
hjic-1161	127	6	a	a	DET
hjic-1161	127	7	later	later	ADJ
hjic-1161	127	8	study	study	NOUN
hjic-1161	127	9	on	on	ADP
hjic-1161	127	10	glucose	glucose	NOUN
hjic-1161	127	11	oxidase	oxidase	NOUN
hjic-1161	127	12	[	[	X
hjic-1161	127	13	40	40	NUM
hjic-1161	127	14	]	]	PUNCT
hjic-1161	127	15	.	.	PUNCT
hjic-1161	128	1	this	this	PRON
hjic-1161	128	2	can	can	AUX
hjic-1161	128	3	be	be	AUX
hjic-1161	128	4	related	relate	VERB
hjic-1161	128	5	to	to	ADP
hjic-1161	128	6	the	the	DET
hjic-1161	128	7	oxidation	oxidation	NOUN
hjic-1161	128	8	of	of	ADP
hjic-1161	128	9	protein	protein	NOUN
hjic-1161	128	10	residues	residue	NOUN
hjic-1161	128	11	in	in	ADP
hjic-1161	128	12	the	the	DET
hjic-1161	128	13	presence	presence	NOUN
hjic-1161	128	14	of	of	ADP
hjic-1161	128	15	oxygen	oxygen	NOUN
hjic-1161	128	16	and	and	CCONJ
hjic-1161	128	17	requires	require	VERB
hjic-1161	128	18	some	some	DET
hjic-1161	128	19	sort	sort	NOUN
hjic-1161	128	20	of	of	ADP
hjic-1161	128	21	quantification	quantification	NOUN
hjic-1161	128	22	to	to	PART
hjic-1161	128	23	enable	enable	VERB
hjic-1161	128	24	development	development	NOUN
hjic-1161	128	25	of	of	ADP
hjic-1161	128	26	the	the	DET
hjic-1161	128	27	reaction	reaction	NOUN
hjic-1161	128	28	by	by	ADP
hjic-1161	128	29	focusing	focus	VERB
hjic-1161	128	30	on	on	ADP
hjic-1161	128	31	resolving	resolve	VERB
hjic-1161	128	32	bottlenecks	bottleneck	NOUN
hjic-1161	128	33	.	.	PUNCT
hjic-1161	129	1	if	if	SCONJ
hjic-1161	129	2	operational	operational	ADJ
hjic-1161	129	3	stability	stability	NOUN
hjic-1161	129	4	is	be	AUX
hjic-1161	129	5	considered	consider	VERB
hjic-1161	129	6	in	in	ADP
hjic-1161	129	7	a	a	DET
hjic-1161	129	8	very	very	ADV
hjic-1161	129	9	simple	simple	ADJ
hjic-1161	129	10	reaction	reaction	NOUN
hjic-1161	129	11	with	with	ADP
hjic-1161	129	12	only	only	ADV
hjic-1161	129	13	a	a	DET
hjic-1161	129	14	basic	basic	ADJ
hjic-1161	129	15	michaelis	michaeli	NOUN
hjic-1161	129	16	-	-	PUNCT
hjic-1161	129	17	menten	menten	ADJ
hjic-1161	129	18	model	model	NOUN
hjic-1161	129	19	,	,	PUNCT
hjic-1161	129	20	its	its	PRON
hjic-1161	129	21	effect	effect	NOUN
hjic-1161	129	22	during	during	ADP
hjic-1161	129	23	dynamic	dynamic	ADJ
hjic-1161	129	24	simulations	simulation	NOUN
hjic-1161	129	25	can	can	AUX
hjic-1161	129	26	be	be	AUX
hjic-1161	129	27	observed	observe	VERB
hjic-1161	129	28	(	(	PUNCT
hjic-1161	129	29	fig	fig	NOUN
hjic-1161	129	30	.	.	PUNCT
hjic-1161	130	1	7a	7a	NUM
hjic-1161	130	2	)	)	PUNCT
hjic-1161	130	3	.	.	PUNCT
hjic-1161	131	1	when	when	SCONJ
hjic-1161	131	2	the	the	DET
hjic-1161	131	3	enzyme	enzyme	NOUN
hjic-1161	131	4	activity	activity	NOUN
hjic-1161	131	5	reduces	reduce	VERB
hjic-1161	131	6	in	in	ADP
hjic-1161	131	7	the	the	DET
hjic-1161	131	8	batch	batch	NOUN
hjic-1161	131	9	reactor	reactor	NOUN
hjic-1161	131	10	,	,	PUNCT
hjic-1161	131	11	the	the	DET
hjic-1161	131	12	shape	shape	NOUN
hjic-1161	131	13	of	of	ADP
hjic-1161	131	14	the	the	DET
hjic-1161	131	15	curve	curve	NOUN
hjic-1161	131	16	changes	change	NOUN
hjic-1161	131	17	slightly	slightly	ADV
hjic-1161	131	18	.	.	PUNCT
hjic-1161	132	1	to	to	ADP
hjic-1161	132	2	the	the	DET
hjic-1161	132	3	untrained	untrained	ADJ
hjic-1161	132	4	eye	eye	NOUN
hjic-1161	132	5	,	,	PUNCT
hjic-1161	132	6	this	this	PRON
hjic-1161	132	7	can	can	AUX
hjic-1161	132	8	also	also	ADV
hjic-1161	132	9	resemble	resemble	VERB
hjic-1161	132	10	the	the	DET
hjic-1161	132	11	result	result	NOUN
hjic-1161	132	12	of	of	ADP
hjic-1161	132	13	reaching	reach	VERB
hjic-1161	132	14	equilibrium	equilibrium	NOUN
hjic-1161	132	15	or	or	CCONJ
hjic-1161	132	16	product	product	NOUN
hjic-1161	132	17	inhibition	inhibition	NOUN
hjic-1161	132	18	.	.	PUNCT
hjic-1161	133	1	therefore	therefore	ADV
hjic-1161	133	2	,	,	PUNCT
hjic-1161	133	3	if	if	SCONJ
hjic-1161	133	4	the	the	DET
hjic-1161	133	5	kinetics	kinetic	NOUN
hjic-1161	133	6	of	of	ADP
hjic-1161	133	7	the	the	DET
hjic-1161	133	8	reaction	reaction	NOUN
hjic-1161	133	9	are	be	AUX
hjic-1161	133	10	completely	completely	ADV
hjic-1161	133	11	unknown	unknown	ADJ
hjic-1161	133	12	,	,	PUNCT
hjic-1161	133	13	it	it	PRON
hjic-1161	133	14	is	be	AUX
hjic-1161	133	15	very	very	ADV
hjic-1161	133	16	difficult	difficult	ADJ
hjic-1161	133	17	to	to	PART
hjic-1161	133	18	draw	draw	VERB
hjic-1161	133	19	the	the	DET
hjic-1161	133	20	right	right	ADJ
hjic-1161	133	21	conclusion	conclusion	NOUN
hjic-1161	133	22	.	.	PUNCT
hjic-1161	134	1	the	the	DET
hjic-1161	134	2	situation	situation	NOUN
hjic-1161	134	3	is	be	AUX
hjic-1161	134	4	quite	quite	ADV
hjic-1161	134	5	different	different	ADJ
hjic-1161	134	6	if	if	SCONJ
hjic-1161	134	7	the	the	DET
hjic-1161	134	8	continuous	continuous	ADJ
hjic-1161	134	9	stirred	stirred	ADJ
hjic-1161	134	10	tank	tank	NOUN
hjic-1161	134	11	reactor	reactor	NOUN
hjic-1161	134	12	is	be	AUX
hjic-1161	134	13	used	use	VERB
hjic-1161	134	14	,	,	PUNCT
hjic-1161	134	15	since	since	SCONJ
hjic-1161	134	16	this	this	DET
hjic-1161	134	17	reactor	reactor	NOUN
hjic-1161	134	18	ideally	ideally	ADV
hjic-1161	134	19	works	work	VERB
hjic-1161	134	20	at	at	ADP
hjic-1161	134	21	a	a	DET
hjic-1161	134	22	stationary	stationary	ADJ
hjic-1161	134	23	state	state	NOUN
hjic-1161	134	24	and	and	CCONJ
hjic-1161	134	25	,	,	PUNCT
hjic-1161	134	26	therefore	therefore	ADV
hjic-1161	134	27	,	,	PUNCT
hjic-1161	134	28	no	no	DET
hjic-1161	134	29	changes	change	NOUN
hjic-1161	134	30	in	in	ADP
hjic-1161	134	31	enzyme	enzyme	NOUN
hjic-1161	134	32	activity	activity	NOUN
hjic-1161	134	33	nor	nor	CCONJ
hjic-1161	134	34	in	in	ADP
hjic-1161	134	35	stationary	stationary	ADJ
hjic-1161	134	36	concentrations	concentration	NOUN
hjic-1161	134	37	of	of	ADP
hjic-1161	134	38	reactants	reactant	NOUN
hjic-1161	134	39	and	and	CCONJ
hjic-1161	134	40	products	product	NOUN
hjic-1161	134	41	occur	occur	VERB
hjic-1161	134	42	.	.	PUNCT
hjic-1161	135	1	hence	hence	ADV
hjic-1161	135	2	,	,	PUNCT
hjic-1161	135	3	enzyme	enzyme	NOUN
hjic-1161	135	4	operational	operational	ADJ
hjic-1161	135	5	stability	stability	NOUN
hjic-1161	135	6	decay	decay	VERB
hjic-1161	135	7	in	in	ADP
hjic-1161	135	8	cstrs	cstrs	ADJ
hjic-1161	135	9	results	result	NOUN
hjic-1161	135	10	in	in	ADP
hjic-1161	135	11	the	the	DET
hjic-1161	135	12	stationary	stationary	ADJ
hjic-1161	135	13	state	state	NOUN
hjic-1161	135	14	being	be	AUX
hjic-1161	135	15	lost	lose	VERB
hjic-1161	135	16	and	and	CCONJ
hjic-1161	135	17	the	the	DET
hjic-1161	135	18	clearly	clearly	ADV
hjic-1161	135	19	visible	visible	ADJ
hjic-1161	135	20	shape	shape	NOUN
hjic-1161	135	21	of	of	ADP
hjic-1161	135	22	the	the	DET
hjic-1161	135	23	curve	curve	NOUN
hjic-1161	135	24	caused	cause	VERB
hjic-1161	135	25	by	by	ADP
hjic-1161	135	26	the	the	DET
hjic-1161	135	27	reduction	reduction	NOUN
hjic-1161	135	28	in	in	ADP
hjic-1161	135	29	enzyme	enzyme	NOUN
hjic-1161	135	30	activity	activity	NOUN
hjic-1161	135	31	(	(	PUNCT
hjic-1161	135	32	fig	fig	NOUN
hjic-1161	135	33	.	.	PUNCT
hjic-1161	136	1	7b	7b	NOUN
hjic-1161	136	2	)	)	PUNCT
hjic-1161	136	3	.	.	PUNCT
hjic-1161	137	1	a	a	DET
hjic-1161	137	2	third	third	ADJ
hjic-1161	137	3	type	type	NOUN
hjic-1161	137	4	of	of	ADP
hjic-1161	137	5	reactor	reactor	NOUN
hjic-1161	137	6	often	often	ADV
hjic-1161	137	7	applied	apply	VERB
hjic-1161	137	8	in	in	ADP
hjic-1161	137	9	biocatalysis	biocatalysis	NOUN
hjic-1161	137	10	due	due	ADP
hjic-1161	137	11	to	to	ADP
hjic-1161	137	12	substrate	substrate	NOUN
hjic-1161	137	13	inhibition	inhibition	NOUN
hjic-1161	137	14	are	be	AUX
hjic-1161	137	15	fed	feed	VERB
hjic-1161	137	16	-	-	PUNCT
hjic-1161	137	17	batch	batch	NOUN
hjic-1161	137	18	bioreactors	bioreactor	NOUN
hjic-1161	137	19	.	.	PUNCT
hjic-1161	138	1	although	although	SCONJ
hjic-1161	138	2	enzyme	enzyme	NOUN
hjic-1161	138	3	operational	operational	ADJ
hjic-1161	138	4	stability	stability	NOUN
hjic-1161	138	5	decay	decay	NOUN
hjic-1161	138	6	can	can	AUX
hjic-1161	138	7	be	be	AUX
hjic-1161	138	8	observed	observe	VERB
hjic-1161	138	9	from	from	ADP
hjic-1161	138	10	the	the	DET
hjic-1161	138	11	shape	shape	NOUN
hjic-1161	138	12	of	of	ADP
hjic-1161	138	13	the	the	DET
hjic-1161	138	14	curve	curve	NOUN
hjic-1161	138	15	(	(	PUNCT
hjic-1161	138	16	fig	fig	NOUN
hjic-1161	138	17	.	.	PUNCT
hjic-1161	139	1	7c	7c	NUM
hjic-1161	139	2	)	)	PUNCT
hjic-1161	139	3	,	,	PUNCT
hjic-1161	139	4	here	here	ADV
hjic-1161	139	5	,	,	PUNCT
hjic-1161	139	6	like	like	ADP
hjic-1161	139	7	in	in	ADP
hjic-1161	139	8	the	the	DET
hjic-1161	139	9	case	case	NOUN
hjic-1161	139	10	of	of	ADP
hjic-1161	139	11	the	the	DET
hjic-1161	139	12	batch	batch	NOUN
hjic-1161	139	13	reactor	reactor	NOUN
hjic-1161	139	14	,	,	PUNCT
hjic-1161	139	15	it	it	PRON
hjic-1161	139	16	is	be	AUX
hjic-1161	139	17	more	more	ADV
hjic-1161	139	18	difficult	difficult	ADJ
hjic-1161	139	19	to	to	PART
hjic-1161	139	20	clearly	clearly	ADV
hjic-1161	139	21	define	define	VERB
hjic-1161	139	22	the	the	DET
hjic-1161	139	23	reason	reason	NOUN
hjic-1161	139	24	for	for	ADP
hjic-1161	139	25	this	this	DET
hjic-1161	139	26	trend	trend	NOUN
hjic-1161	139	27	.	.	PUNCT
hjic-1161	140	1	the	the	DET
hjic-1161	140	2	answer	answer	NOUN
hjic-1161	140	3	that	that	PRON
hjic-1161	140	4	is	be	AUX
hjic-1161	140	5	suggested	suggest	VERB
hjic-1161	140	6	here	here	ADV
hjic-1161	140	7	concerns	concern	VERB
hjic-1161	140	8	quantification	quantification	NOUN
hjic-1161	140	9	of	of	ADP
hjic-1161	140	10	enzyme	enzyme	NOUN
hjic-1161	140	11	activity	activity	NOUN
hjic-1161	140	12	during	during	ADP
hjic-1161	140	13	the	the	DET
hjic-1161	140	14	reaction	reaction	NOUN
hjic-1161	140	15	.	.	PUNCT
hjic-1161	141	1	5	5	X
hjic-1161	141	2	.	.	X
hjic-1161	141	3	choosing	choose	VERB
hjic-1161	141	4	the	the	DET
hjic-1161	141	5	best	good	ADJ
hjic-1161	141	6	enzyme	enzyme	NOUN
hjic-1161	141	7	variant	variant	NOUN
hjic-1161	141	8	for	for	ADP
hjic-1161	141	9	the	the	DET
hjic-1161	141	10	reaction	reaction	NOUN
hjic-1161	141	11	techniques	technique	NOUN
hjic-1161	141	12	for	for	ADP
hjic-1161	141	13	genetically	genetically	ADV
hjic-1161	141	14	modifying	modify	VERB
hjic-1161	141	15	enzymes	enzyme	NOUN
hjic-1161	141	16	have	have	AUX
hjic-1161	141	17	advanced	advance	VERB
hjic-1161	141	18	greatly	greatly	ADV
hjic-1161	141	19	over	over	ADP
hjic-1161	141	20	recent	recent	ADJ
hjic-1161	141	21	years	year	NOUN
hjic-1161	141	22	and	and	CCONJ
hjic-1161	141	23	can	can	AUX
hjic-1161	141	24	be	be	AUX
hjic-1161	141	25	applied	apply	VERB
hjic-1161	141	26	to	to	PART
hjic-1161	141	27	produce	produce	VERB
hjic-1161	141	28	industrially	industrially	ADV
hjic-1161	141	29	suitable	suitable	ADJ
hjic-1161	141	30	catalysts	catalyst	NOUN
hjic-1161	141	31	more	more	ADV
hjic-1161	141	32	quickly	quickly	ADV
hjic-1161	141	33	and	and	CCONJ
hjic-1161	141	34	50	50	NUM
hjic-1161	141	35	pp	pp	NOUN
hjic-1161	141	36	.	.	PUNCT
hjic-1161	142	1	45–55	45–55	NUM
hjic-1161	142	2	(	(	PUNCT
hjic-1161	142	3	2022	2022	NUM
hjic-1161	142	4	)	)	PUNCT
hjic-1161	142	5	52	52	NUM
hjic-1161	142	6	milčić	milčić	ADJ
hjic-1161	142	7	,	,	PUNCT
hjic-1161	142	8	ćevid	ćevid	PROPN
hjic-1161	142	9	,	,	PUNCT
hjic-1161	142	10	çakar	çakar	NOUN
hjic-1161	142	11	,	,	PUNCT
hjic-1161	142	12	sudar	sudar	ADJ
hjic-1161	142	13	and	and	CCONJ
hjic-1161	142	14	findrik	findrik	VERB
hjic-1161	142	15	blažević	blažević	PROPN
hjic-1161	143	1	(	(	PUNCT
hjic-1161	143	2	a	a	X
hjic-1161	143	3	)	)	PUNCT
hjic-1161	143	4	(	(	PUNCT
hjic-1161	143	5	b	b	X
hjic-1161	143	6	)	)	PUNCT
hjic-1161	143	7	(	(	PUNCT
hjic-1161	143	8	c	c	X
hjic-1161	143	9	)	)	PUNCT
hjic-1161	143	10	(	(	PUNCT
hjic-1161	143	11	d	d	X
hjic-1161	143	12	)	)	PUNCT
hjic-1161	143	13	figure	figure	NOUN
hjic-1161	143	14	6	6	NUM
hjic-1161	143	15	:	:	PUNCT
hjic-1161	143	16	(	(	PUNCT
hjic-1161	143	17	a)the	a)the	DET
hjic-1161	143	18	influence	influence	NOUN
hjic-1161	143	19	of	of	ADP
hjic-1161	143	20	the	the	DET
hjic-1161	143	21	initial	initial	ADJ
hjic-1161	143	22	concentration	concentration	NOUN
hjic-1161	143	23	of	of	ADP
hjic-1161	143	24	formaldehyde	formaldehyde	NOUN
hjic-1161	143	25	on	on	ADP
hjic-1161	143	26	the	the	DET
hjic-1161	143	27	enzyme	enzyme	NOUN
hjic-1161	143	28	activity	activity	NOUN
hjic-1161	143	29	of	of	ADP
hjic-1161	143	30	fsad6q	fsad6q	PROPN
hjic-1161	143	31	during	during	ADP
hjic-1161	143	32	incubation	incubation	NOUN
hjic-1161	143	33	;	;	PUNCT
hjic-1161	143	34	(	(	PUNCT
hjic-1161	143	35	b	b	X
hjic-1161	143	36	)	)	PUNCT
hjic-1161	143	37	dependence	dependence	NOUN
hjic-1161	143	38	of	of	ADP
hjic-1161	143	39	the	the	DET
hjic-1161	143	40	operational	operational	ADJ
hjic-1161	143	41	stability	stability	NOUN
hjic-1161	143	42	decay	decay	NOUN
hjic-1161	143	43	rate	rate	NOUN
hjic-1161	143	44	constants	constant	NOUN
hjic-1161	143	45	of	of	ADP
hjic-1161	143	46	fsad6q	fsad6q	NOUN
hjic-1161	143	47	on	on	ADP
hjic-1161	143	48	the	the	DET
hjic-1161	143	49	initial	initial	ADJ
hjic-1161	143	50	concentration	concentration	NOUN
hjic-1161	143	51	of	of	ADP
hjic-1161	143	52	formaldehyde	formaldehyde	NOUN
hjic-1161	143	53	;	;	PUNCT
hjic-1161	143	54	(	(	PUNCT
hjic-1161	143	55	c	c	X
hjic-1161	143	56	)	)	PUNCT
hjic-1161	143	57	the	the	DET
hjic-1161	143	58	influence	influence	NOUN
hjic-1161	143	59	of	of	ADP
hjic-1161	143	60	the	the	DET
hjic-1161	143	61	initial	initial	ADJ
hjic-1161	143	62	concentration	concentration	NOUN
hjic-1161	143	63	of	of	ADP
hjic-1161	143	64	1,3	1,3	NUM
hjic-1161	143	65	-	-	PUNCT
hjic-1161	143	66	dcp	dcp	NOUN
hjic-1161	143	67	on	on	ADP
hjic-1161	143	68	the	the	DET
hjic-1161	143	69	enzyme	enzyme	NOUN
hjic-1161	143	70	activity	activity	NOUN
hjic-1161	143	71	of	of	ADP
hjic-1161	143	72	hhdh	hhdh	NOUN
hjic-1161	143	73	during	during	ADP
hjic-1161	143	74	incubation	incubation	NOUN
hjic-1161	143	75	;	;	PUNCT
hjic-1161	143	76	(	(	PUNCT
hjic-1161	143	77	d	d	X
hjic-1161	143	78	)	)	PUNCT
hjic-1161	143	79	dependence	dependence	NOUN
hjic-1161	143	80	of	of	ADP
hjic-1161	143	81	the	the	DET
hjic-1161	143	82	operational	operational	ADJ
hjic-1161	143	83	stability	stability	NOUN
hjic-1161	143	84	decay	decay	NOUN
hjic-1161	143	85	rate	rate	NOUN
hjic-1161	143	86	constants	constant	NOUN
hjic-1161	143	87	of	of	ADP
hjic-1161	143	88	hhdh	hhdh	NOUN
hjic-1161	143	89	on	on	ADP
hjic-1161	143	90	the	the	DET
hjic-1161	143	91	initial	initial	ADJ
hjic-1161	143	92	concentration	concentration	NOUN
hjic-1161	143	93	of	of	ADP
hjic-1161	143	94	1,3	1,3	NUM
hjic-1161	143	95	-	-	PUNCT
hjic-1161	143	96	dcp	dcp	NOUN
hjic-1161	143	97	(	(	PUNCT
hjic-1161	143	98	a	a	NOUN
hjic-1161	143	99	)	)	PUNCT
hjic-1161	143	100	(	(	PUNCT
hjic-1161	143	101	b	b	X
hjic-1161	143	102	)	)	PUNCT
hjic-1161	143	103	(	(	PUNCT
hjic-1161	143	104	c	c	X
hjic-1161	143	105	)	)	PUNCT
hjic-1161	143	106	figure	figure	NOUN
hjic-1161	143	107	7	7	NUM
hjic-1161	143	108	:	:	PUNCT
hjic-1161	143	109	the	the	DET
hjic-1161	143	110	effect	effect	NOUN
hjic-1161	143	111	of	of	ADP
hjic-1161	143	112	operational	operational	ADJ
hjic-1161	143	113	stability	stability	NOUN
hjic-1161	143	114	decay	decay	VERB
hjic-1161	143	115	on	on	ADP
hjic-1161	143	116	model	model	NOUN
hjic-1161	143	117	curves	curve	NOUN
hjic-1161	143	118	in	in	ADP
hjic-1161	143	119	different	different	ADJ
hjic-1161	143	120	types	type	NOUN
hjic-1161	143	121	of	of	ADP
hjic-1161	143	122	reactors	reactor	NOUN
hjic-1161	143	123	:	:	PUNCT
hjic-1161	143	124	(	(	PUNCT
hjic-1161	143	125	a	a	X
hjic-1161	143	126	)	)	PUNCT
hjic-1161	143	127	batch	batch	NOUN
hjic-1161	143	128	reactor	reactor	NOUN
hjic-1161	143	129	,	,	PUNCT
hjic-1161	143	130	(	(	PUNCT
hjic-1161	143	131	b	b	X
hjic-1161	143	132	)	)	PUNCT
hjic-1161	143	133	continuous	continuous	ADJ
hjic-1161	143	134	stirred	stir	VERB
hjic-1161	143	135	tank	tank	NOUN
hjic-1161	143	136	reactor	reactor	NOUN
hjic-1161	143	137	,	,	PUNCT
hjic-1161	143	138	(	(	PUNCT
hjic-1161	143	139	c	c	X
hjic-1161	143	140	)	)	PUNCT
hjic-1161	143	141	fed	feed	VERB
hjic-1161	143	142	-	-	PUNCT
hjic-1161	143	143	batch	batch	NOUN
hjic-1161	143	144	bioreactor	bioreactor	NOUN
hjic-1161	143	145	parameter	parameter	NOUN
hjic-1161	143	146	unit	unit	NOUN
hjic-1161	143	147	enzyme	enzyme	NOUN
hjic-1161	143	148	1	1	NUM
hjic-1161	143	149	enzyme	enzyme	NOUN
hjic-1161	143	150	2	2	NUM
hjic-1161	143	151	enzyme	enzyme	NOUN
hjic-1161	143	152	3	3	NUM
hjic-1161	143	153	vm	vm	NOUN
hjic-1161	143	154	u	u	NOUN
hjic-1161	143	155	/	/	SYM
hjic-1161	143	156	mg	mg	PROPN
hjic-1161	143	157	3.42±	3.42±	NUM
hjic-1161	143	158	0.05	0.05	NUM
hjic-1161	143	159	1.74±	1.74±	NUM
hjic-1161	143	160	0.11	0.11	NUM
hjic-1161	143	161	0.74±	0.74±	NUM
hjic-1161	143	162	0.03	0.03	NUM
hjic-1161	143	163	km	km	NOUN
hjic-1161	143	164	mm	mm	PROPN
hjic-1161	143	165	102.24	102.24	NUM
hjic-1161	143	166	±	±	NUM
hjic-1161	143	167	4.01	4.01	NUM
hjic-1161	143	168	67.52	67.52	NUM
hjic-1161	143	169	±	±	NUM
hjic-1161	143	170	7.22	7.22	NUM
hjic-1161	143	171	36.33	36.33	NUM
hjic-1161	143	172	±	±	NUM
hjic-1161	143	173	8.82	8.82	NUM
hjic-1161	144	1	ki	ki	PROPN
hjic-1161	144	2	mm	mm	PROPN
hjic-1161	144	3	679.94	679.94	NUM
hjic-1161	144	4	±	±	NUM
hjic-1161	144	5	38.81	38.81	NUM
hjic-1161	144	6	183.19	183.19	NUM
hjic-1161	144	7	±	±	NUM
hjic-1161	144	8	29.25	29.25	NUM
hjic-1161	144	9	377.28	377.28	NUM
hjic-1161	144	10	±	±	NOUN
hjic-1161	144	11	68.70	68.70	NUM
hjic-1161	144	12	table	table	NOUN
hjic-1161	144	13	2	2	NUM
hjic-1161	144	14	:	:	PUNCT
hjic-1161	144	15	estimated	estimate	VERB
hjic-1161	144	16	kinetic	kinetic	ADJ
hjic-1161	144	17	parameters	parameter	NOUN
hjic-1161	144	18	for	for	ADP
hjic-1161	144	19	the	the	DET
hjic-1161	144	20	three	three	NUM
hjic-1161	144	21	enzyme	enzyme	NOUN
hjic-1161	144	22	variants	variant	NOUN
hjic-1161	144	23	cost	cost	NOUN
hjic-1161	144	24	-	-	PUNCT
hjic-1161	144	25	effectively	effectively	ADV
hjic-1161	144	26	.	.	PUNCT
hjic-1161	145	1	however	however	ADV
hjic-1161	145	2	,	,	PUNCT
hjic-1161	145	3	in	in	ADP
hjic-1161	145	4	order	order	NOUN
hjic-1161	145	5	for	for	SCONJ
hjic-1161	145	6	new	new	ADJ
hjic-1161	145	7	biocatalysts	biocatalyst	NOUN
hjic-1161	145	8	to	to	PART
hjic-1161	145	9	be	be	AUX
hjic-1161	145	10	worthy	worthy	ADJ
hjic-1161	145	11	of	of	ADP
hjic-1161	145	12	industrial	industrial	ADJ
hjic-1161	145	13	large	large	ADJ
hjic-1161	145	14	-	-	PUNCT
hjic-1161	145	15	scale	scale	NOUN
hjic-1161	145	16	production	production	NOUN
hjic-1161	145	17	,	,	PUNCT
hjic-1161	145	18	reliable	reliable	ADJ
hjic-1161	145	19	and	and	CCONJ
hjic-1161	145	20	comprehensive	comprehensive	ADJ
hjic-1161	145	21	methods	method	NOUN
hjic-1161	145	22	for	for	ADP
hjic-1161	145	23	the	the	DET
hjic-1161	145	24	initial	initial	ADJ
hjic-1161	145	25	kinetic	kinetic	ADJ
hjic-1161	145	26	characterization	characterization	NOUN
hjic-1161	145	27	of	of	ADP
hjic-1161	145	28	possible	possible	ADJ
hjic-1161	145	29	enzyme	enzyme	NOUN
hjic-1161	145	30	variants	variant	NOUN
hjic-1161	145	31	are	be	AUX
hjic-1161	145	32	necessary	necessary	ADJ
hjic-1161	145	33	.	.	PUNCT
hjic-1161	146	1	in	in	ADP
hjic-1161	146	2	search	search	NOUN
hjic-1161	146	3	of	of	ADP
hjic-1161	146	4	an	an	DET
hjic-1161	146	5	optimal	optimal	ADJ
hjic-1161	146	6	enzyme	enzyme	NOUN
hjic-1161	146	7	variant	variant	NOUN
hjic-1161	146	8	,	,	PUNCT
hjic-1161	146	9	the	the	DET
hjic-1161	146	10	enzyme	enzyme	NOUN
hjic-1161	146	11	with	with	ADP
hjic-1161	146	12	the	the	DET
hjic-1161	146	13	highest	high	ADJ
hjic-1161	146	14	activity	activity	NOUN
hjic-1161	146	15	(	(	PUNCT
hjic-1161	146	16	highest	high	ADJ
hjic-1161	146	17	vm	vm	NOUN
hjic-1161	146	18	value	value	NOUN
hjic-1161	146	19	)	)	PUNCT
hjic-1161	146	20	or	or	CCONJ
hjic-1161	146	21	highest	high	ADJ
hjic-1161	146	22	affinity	affinity	NOUN
hjic-1161	146	23	for	for	ADP
hjic-1161	146	24	the	the	DET
hjic-1161	146	25	substrate	substrate	NOUN
hjic-1161	146	26	(	(	PUNCT
hjic-1161	146	27	lowest	low	ADJ
hjic-1161	146	28	km	km	NOUN
hjic-1161	146	29	value	value	NOUN
hjic-1161	146	30	)	)	PUNCT
hjic-1161	146	31	is	be	AUX
hjic-1161	146	32	often	often	ADV
hjic-1161	146	33	sought	seek	VERB
hjic-1161	146	34	[	[	X
hjic-1161	146	35	41	41	NUM
hjic-1161	146	36	]	]	PUNCT
hjic-1161	146	37	.	.	PUNCT
hjic-1161	147	1	this	this	PRON
hjic-1161	147	2	is	be	AUX
hjic-1161	147	3	only	only	ADV
hjic-1161	147	4	valid	valid	ADJ
hjic-1161	147	5	when	when	SCONJ
hjic-1161	147	6	michaelis	michaeli	NOUN
hjic-1161	147	7	-	-	PUNCT
hjic-1161	147	8	menten	menten	ADJ
hjic-1161	147	9	kinetics	kinetic	NOUN
hjic-1161	147	10	are	be	AUX
hjic-1161	147	11	applied	apply	VERB
hjic-1161	147	12	,	,	PUNCT
hjic-1161	147	13	however	however	ADV
hjic-1161	147	14	,	,	PUNCT
hjic-1161	147	15	in	in	ADP
hjic-1161	147	16	practice	practice	NOUN
hjic-1161	147	17	,	,	PUNCT
hjic-1161	147	18	the	the	DET
hjic-1161	147	19	situation	situation	NOUN
hjic-1161	147	20	is	be	AUX
hjic-1161	147	21	rarely	rarely	ADV
hjic-1161	147	22	that	that	SCONJ
hjic-1161	147	23	simple	simple	ADJ
hjic-1161	147	24	.	.	PUNCT
hjic-1161	148	1	for	for	ADP
hjic-1161	148	2	example	example	NOUN
hjic-1161	148	3	,	,	PUNCT
hjic-1161	148	4	this	this	PRON
hjic-1161	148	5	is	be	AUX
hjic-1161	148	6	not	not	PART
hjic-1161	148	7	so	so	ADV
hjic-1161	148	8	in	in	ADP
hjic-1161	148	9	the	the	DET
hjic-1161	148	10	case	case	NOUN
hjic-1161	148	11	hungarian	hungarian	ADJ
hjic-1161	148	12	journal	journal	NOUN
hjic-1161	148	13	of	of	ADP
hjic-1161	148	14	industry	industry	NOUN
hjic-1161	148	15	and	and	CCONJ
hjic-1161	148	16	chemistry	chemistry	NOUN
hjic-1161	148	17	enzyme	enzyme	NOUN
hjic-1161	148	18	reaction	reaction	NOUN
hjic-1161	148	19	engineering	engineering	NOUN
hjic-1161	148	20	as	as	ADP
hjic-1161	148	21	a	a	DET
hjic-1161	148	22	tool	tool	NOUN
hjic-1161	148	23	53	53	NUM
hjic-1161	148	24	(	(	PUNCT
hjic-1161	148	25	a	a	NOUN
hjic-1161	148	26	)	)	PUNCT
hjic-1161	148	27	(	(	PUNCT
hjic-1161	148	28	b	b	NOUN
hjic-1161	148	29	)	)	PUNCT
hjic-1161	148	30	5(c	5(c	NUM
hjic-1161	148	31	)	)	PUNCT
hjic-1161	148	32	figure	figure	NOUN
hjic-1161	148	33	8	8	NUM
hjic-1161	148	34	:	:	PUNCT
hjic-1161	148	35	comparison	comparison	NOUN
hjic-1161	148	36	between	between	ADP
hjic-1161	148	37	the	the	DET
hjic-1161	148	38	three	three	NUM
hjic-1161	148	39	enzyme	enzyme	NOUN
hjic-1161	148	40	variants	variant	NOUN
hjic-1161	148	41	which	which	PRON
hjic-1161	148	42	exhibit	exhibit	VERB
hjic-1161	148	43	substrate	substrate	NOUN
hjic-1161	148	44	inhibition	inhibition	NOUN
hjic-1161	148	45	at	at	ADP
hjic-1161	148	46	different	different	ADJ
hjic-1161	148	47	levels	level	NOUN
hjic-1161	148	48	of	of	ADP
hjic-1161	148	49	michaelis	michaeli	NOUN
hjic-1161	148	50	-	-	ADJ
hjic-1161	148	51	menten	menten	VERB
hjic-1161	148	52	kinetics	kinetic	NOUN
hjic-1161	148	53	with	with	ADP
hjic-1161	148	54	substrate	substrate	NOUN
hjic-1161	148	55	inhibition	inhibition	NOUN
hjic-1161	148	56	,	,	PUNCT
hjic-1161	148	57	when	when	SCONJ
hjic-1161	148	58	the	the	DET
hjic-1161	148	59	substrate	substrate	NOUN
hjic-1161	148	60	concentration	concentration	NOUN
hjic-1161	148	61	used	use	VERB
hjic-1161	148	62	during	during	ADP
hjic-1161	148	63	screening	screen	VERB
hjic-1161	148	64	is	be	AUX
hjic-1161	148	65	critical	critical	ADJ
hjic-1161	148	66	.	.	PUNCT
hjic-1161	149	1	given	give	VERB
hjic-1161	149	2	that	that	DET
hjic-1161	149	3	screening	screening	NOUN
hjic-1161	149	4	seems	seem	VERB
hjic-1161	149	5	to	to	PART
hjic-1161	149	6	only	only	ADV
hjic-1161	149	7	be	be	AUX
hjic-1161	149	8	conducted	conduct	VERB
hjic-1161	149	9	at	at	ADP
hjic-1161	149	10	one	one	NUM
hjic-1161	149	11	concentration	concentration	NOUN
hjic-1161	149	12	,	,	PUNCT
hjic-1161	149	13	accurate	accurate	ADJ
hjic-1161	149	14	data	datum	NOUN
hjic-1161	149	15	of	of	ADP
hjic-1161	149	16	enzyme	enzyme	NOUN
hjic-1161	149	17	activity	activity	NOUN
hjic-1161	149	18	is	be	AUX
hjic-1161	149	19	not	not	PART
hjic-1161	149	20	provided	provide	VERB
hjic-1161	149	21	,	,	PUNCT
hjic-1161	149	22	considering	consider	VERB
hjic-1161	149	23	that	that	SCONJ
hjic-1161	149	24	the	the	DET
hjic-1161	149	25	shape	shape	NOUN
hjic-1161	149	26	of	of	ADP
hjic-1161	149	27	the	the	DET
hjic-1161	149	28	michaelismenten	michaelismenten	VERB
hjic-1161	149	29	curve	curve	NOUN
hjic-1161	149	30	is	be	AUX
hjic-1161	149	31	unknown	unknown	ADJ
hjic-1161	149	32	.	.	PUNCT
hjic-1161	150	1	since	since	SCONJ
hjic-1161	150	2	variants	variant	NOUN
hjic-1161	150	3	of	of	ADP
hjic-1161	150	4	the	the	DET
hjic-1161	150	5	same	same	ADJ
hjic-1161	150	6	enzyme	enzyme	NOUN
hjic-1161	150	7	differ	differ	VERB
hjic-1161	150	8	with	with	ADP
hjic-1161	150	9	regard	regard	NOUN
hjic-1161	150	10	to	to	ADP
hjic-1161	150	11	the	the	DET
hjic-1161	150	12	estimated	estimate	VERB
hjic-1161	150	13	values	value	NOUN
hjic-1161	150	14	of	of	ADP
hjic-1161	150	15	their	their	PRON
hjic-1161	150	16	kinetic	kinetic	ADJ
hjic-1161	150	17	constants	constant	NOUN
hjic-1161	150	18	,	,	PUNCT
hjic-1161	150	19	combinations	combination	NOUN
hjic-1161	150	20	of	of	ADP
hjic-1161	150	21	the	the	DET
hjic-1161	150	22	relevant	relevant	ADJ
hjic-1161	150	23	kinetic	kinetic	ADJ
hjic-1161	150	24	parameters	parameter	NOUN
hjic-1161	150	25	(	(	PUNCT
hjic-1161	150	26	vm	vm	PROPN
hjic-1161	150	27	,	,	PUNCT
hjic-1161	150	28	km	km	PROPN
hjic-1161	150	29	,	,	PUNCT
hjic-1161	150	30	ki	ki	PROPN
hjic-1161	150	31	)	)	PUNCT
hjic-1161	150	32	were	be	AUX
hjic-1161	150	33	obtained	obtain	VERB
hjic-1161	150	34	for	for	ADP
hjic-1161	150	35	each	each	DET
hjic-1161	150	36	variant	variant	NOUN
hjic-1161	150	37	(	(	PUNCT
hjic-1161	150	38	table	table	NOUN
hjic-1161	150	39	2	2	NUM
hjic-1161	150	40	)	)	PUNCT
hjic-1161	150	41	.	.	PUNCT
hjic-1161	151	1	although	although	SCONJ
hjic-1161	151	2	it	it	PRON
hjic-1161	151	3	may	may	AUX
hjic-1161	151	4	be	be	AUX
hjic-1161	151	5	assumed	assume	VERB
hjic-1161	151	6	that	that	SCONJ
hjic-1161	151	7	the	the	DET
hjic-1161	151	8	enzyme	enzyme	NOUN
hjic-1161	151	9	with	with	ADP
hjic-1161	151	10	the	the	DET
hjic-1161	151	11	minimum	minimum	NOUN
hjic-1161	151	12	michaelis	michaeli	NOUN
hjic-1161	151	13	constant	constant	ADJ
hjic-1161	151	14	and	and	CCONJ
hjic-1161	151	15	highest	high	ADJ
hjic-1161	151	16	activity	activity	NOUN
hjic-1161	151	17	is	be	AUX
hjic-1161	151	18	most	most	ADV
hjic-1161	151	19	suitable	suitable	ADJ
hjic-1161	151	20	,	,	PUNCT
hjic-1161	151	21	in	in	ADP
hjic-1161	151	22	practice	practice	NOUN
hjic-1161	151	23	,	,	PUNCT
hjic-1161	151	24	this	this	DET
hjic-1161	151	25	enzyme	enzyme	NOUN
hjic-1161	151	26	may	may	AUX
hjic-1161	151	27	exhibit	exhibit	VERB
hjic-1161	151	28	a	a	DET
hjic-1161	151	29	higher	high	ADJ
hjic-1161	151	30	level	level	NOUN
hjic-1161	151	31	of	of	ADP
hjic-1161	151	32	substrate	substrate	NOUN
hjic-1161	151	33	inhibition	inhibition	NOUN
hjic-1161	151	34	as	as	ADP
hjic-1161	151	35	a	a	DET
hjic-1161	151	36	result	result	NOUN
hjic-1161	151	37	.	.	PUNCT
hjic-1161	152	1	three	three	NUM
hjic-1161	152	2	enzyme	enzyme	NOUN
hjic-1161	152	3	variants	variant	NOUN
hjic-1161	152	4	were	be	AUX
hjic-1161	152	5	kinetically	kinetically	ADV
hjic-1161	152	6	characterized	characterize	VERB
hjic-1161	152	7	and	and	CCONJ
hjic-1161	152	8	the	the	DET
hjic-1161	152	9	dependence	dependence	NOUN
hjic-1161	152	10	of	of	ADP
hjic-1161	152	11	their	their	PRON
hjic-1161	152	12	specific	specific	ADJ
hjic-1161	152	13	enzyme	enzyme	NOUN
hjic-1161	152	14	activities	activity	NOUN
hjic-1161	152	15	on	on	ADP
hjic-1161	152	16	the	the	DET
hjic-1161	152	17	substrate	substrate	NOUN
hjic-1161	152	18	concentration	concentration	NOUN
hjic-1161	152	19	is	be	AUX
hjic-1161	152	20	presented	present	VERB
hjic-1161	152	21	in	in	ADP
hjic-1161	152	22	fig	fig	NOUN
hjic-1161	152	23	.	.	PUNCT
hjic-1161	153	1	8	8	NUM
hjic-1161	153	2	,	,	PUNCT
hjic-1161	153	3	while	while	SCONJ
hjic-1161	153	4	the	the	DET
hjic-1161	153	5	kinetic	kinetic	ADJ
hjic-1161	153	6	parameters	parameter	NOUN
hjic-1161	153	7	are	be	AUX
hjic-1161	153	8	shown	show	VERB
hjic-1161	153	9	in	in	ADP
hjic-1161	153	10	table	table	NOUN
hjic-1161	153	11	2	2	NUM
hjic-1161	153	12	.	.	PUNCT
hjic-1161	154	1	the	the	DET
hjic-1161	154	2	best	well	ADV
hjic-1161	154	3	applied	apply	VERB
hjic-1161	154	4	variant	variant	NOUN
hjic-1161	154	5	was	be	AUX
hjic-1161	154	6	found	find	VERB
hjic-1161	154	7	to	to	PART
hjic-1161	154	8	be	be	AUX
hjic-1161	154	9	enzyme	enzyme	NOUN
hjic-1161	154	10	1	1	NUM
hjic-1161	154	11	,	,	PUNCT
hjic-1161	154	12	written	write	VERB
hjic-1161	154	13	in	in	ADP
hjic-1161	154	14	bold	bold	ADJ
hjic-1161	154	15	,	,	PUNCT
hjic-1161	154	16	in	in	ADP
hjic-1161	154	17	table	table	NOUN
hjic-1161	154	18	2	2	NUM
hjic-1161	154	19	because	because	SCONJ
hjic-1161	154	20	the	the	DET
hjic-1161	154	21	level	level	NOUN
hjic-1161	154	22	of	of	ADP
hjic-1161	154	23	substrate	substrate	NOUN
hjic-1161	154	24	inhibition	inhibition	NOUN
hjic-1161	154	25	it	it	PRON
hjic-1161	154	26	is	be	AUX
hjic-1161	154	27	subjected	subject	VERB
hjic-1161	154	28	to	to	PART
hjic-1161	154	29	is	be	AUX
hjic-1161	154	30	by	by	ADP
hjic-1161	154	31	far	far	ADV
hjic-1161	154	32	the	the	DET
hjic-1161	154	33	least	least	ADJ
hjic-1161	154	34	pronounced	pronounce	VERB
hjic-1161	154	35	.	.	PUNCT
hjic-1161	155	1	in	in	ADP
hjic-1161	155	2	practice	practice	NOUN
hjic-1161	155	3	,	,	PUNCT
hjic-1161	155	4	this	this	PRON
hjic-1161	155	5	means	mean	VERB
hjic-1161	155	6	a	a	DET
hjic-1161	155	7	broader	broad	ADJ
hjic-1161	155	8	substrate	substrate	NOUN
hjic-1161	155	9	concentration	concentration	NOUN
hjic-1161	155	10	area	area	NOUN
hjic-1161	155	11	in	in	ADP
hjic-1161	155	12	which	which	PRON
hjic-1161	155	13	the	the	DET
hjic-1161	155	14	highest	high	ADJ
hjic-1161	155	15	enzyme	enzyme	NOUN
hjic-1161	155	16	activities	activity	NOUN
hjic-1161	155	17	can	can	AUX
hjic-1161	155	18	be	be	AUX
hjic-1161	155	19	obtained	obtain	VERB
hjic-1161	155	20	in	in	ADP
hjic-1161	155	21	the	the	DET
hjic-1161	155	22	reactor	reactor	NOUN
hjic-1161	155	23	(	(	PUNCT
hjic-1161	155	24	fig	fig	NOUN
hjic-1161	155	25	.	.	PUNCT
hjic-1161	156	1	8a	8a	NUM
hjic-1161	156	2	)	)	PUNCT
hjic-1161	157	1	and	and	CCONJ
hjic-1161	157	2	enhanced	enhance	VERB
hjic-1161	157	3	stability	stability	NOUN
hjic-1161	157	4	of	of	ADP
hjic-1161	157	5	the	the	DET
hjic-1161	157	6	reactor	reactor	NOUN
hjic-1161	157	7	’s	’s	PART
hjic-1161	157	8	operating	operating	NOUN
hjic-1161	157	9	conditions	condition	NOUN
hjic-1161	157	10	.	.	PUNCT
hjic-1161	158	1	simulations	simulation	NOUN
hjic-1161	158	2	presented	present	VERB
hjic-1161	158	3	in	in	ADP
hjic-1161	158	4	fig	fig	NOUN
hjic-1161	158	5	.	.	PUNCT
hjic-1161	159	1	8	8	NUM
hjic-1161	159	2	also	also	ADV
hjic-1161	159	3	show	show	VERB
hjic-1161	159	4	that	that	SCONJ
hjic-1161	159	5	when	when	SCONJ
hjic-1161	159	6	screening	screen	VERB
hjic-1161	159	7	the	the	DET
hjic-1161	159	8	enzyme	enzyme	NOUN
hjic-1161	159	9	variants	variant	NOUN
hjic-1161	159	10	,	,	PUNCT
hjic-1161	159	11	it	it	PRON
hjic-1161	159	12	is	be	AUX
hjic-1161	159	13	important	important	ADJ
hjic-1161	159	14	to	to	PART
hjic-1161	159	15	not	not	PART
hjic-1161	159	16	only	only	ADV
hjic-1161	159	17	evaluate	evaluate	VERB
hjic-1161	159	18	their	their	PRON
hjic-1161	159	19	activities	activity	NOUN
hjic-1161	159	20	but	but	CCONJ
hjic-1161	159	21	also	also	ADV
hjic-1161	159	22	estimate	estimate	VERB
hjic-1161	159	23	all	all	DET
hjic-1161	159	24	their	their	PRON
hjic-1161	159	25	kinetic	kinetic	ADJ
hjic-1161	159	26	parameters	parameter	NOUN
hjic-1161	159	27	.	.	PUNCT
hjic-1161	160	1	in	in	ADP
hjic-1161	160	2	further	further	ADJ
hjic-1161	160	3	stages	stage	NOUN
hjic-1161	160	4	of	of	ADP
hjic-1161	160	5	process	process	NOUN
hjic-1161	160	6	development	development	NOUN
hjic-1161	160	7	,	,	PUNCT
hjic-1161	160	8	the	the	DET
hjic-1161	160	9	application	application	NOUN
hjic-1161	160	10	of	of	ADP
hjic-1161	160	11	reaction	reaction	NOUN
hjic-1161	160	12	engineering	engineering	NOUN
hjic-1161	160	13	to	to	PART
hjic-1161	160	14	identify	identify	VERB
hjic-1161	160	15	process	process	NOUN
hjic-1161	160	16	bottlenecks	bottleneck	NOUN
hjic-1161	160	17	is	be	AUX
hjic-1161	160	18	required	require	VERB
hjic-1161	160	19	to	to	PART
hjic-1161	160	20	exploit	exploit	VERB
hjic-1161	160	21	the	the	DET
hjic-1161	160	22	full	full	ADJ
hjic-1161	160	23	potential	potential	NOUN
hjic-1161	160	24	of	of	ADP
hjic-1161	160	25	novel	novel	ADJ
hjic-1161	160	26	enzymes	enzyme	NOUN
hjic-1161	160	27	.	.	PUNCT
hjic-1161	161	1	to	to	PART
hjic-1161	161	2	develop	develop	VERB
hjic-1161	161	3	novel	novel	ADJ
hjic-1161	161	4	green	green	ADJ
hjic-1161	161	5	routes	route	NOUN
hjic-1161	161	6	in	in	ADP
hjic-1161	161	7	biocatalysis	biocatalysis	NOUN
hjic-1161	161	8	and	and	CCONJ
hjic-1161	161	9	scale	scale	VERB
hjic-1161	161	10	them	they	PRON
hjic-1161	161	11	up	up	ADP
hjic-1161	161	12	,	,	PUNCT
hjic-1161	161	13	it	it	PRON
hjic-1161	161	14	is	be	AUX
hjic-1161	161	15	crucial	crucial	ADJ
hjic-1161	161	16	to	to	PART
hjic-1161	161	17	adopt	adopt	VERB
hjic-1161	161	18	a	a	DET
hjic-1161	161	19	multidisciplinary	multidisciplinary	ADJ
hjic-1161	161	20	approach	approach	NOUN
hjic-1161	161	21	by	by	ADP
hjic-1161	161	22	combining	combine	VERB
hjic-1161	161	23	the	the	DET
hjic-1161	161	24	fields	field	NOUN
hjic-1161	161	25	of	of	ADP
hjic-1161	161	26	chemistry	chemistry	NOUN
hjic-1161	161	27	,	,	PUNCT
hjic-1161	161	28	biology	biology	NOUN
hjic-1161	161	29	and	and	CCONJ
hjic-1161	161	30	chemical	chemical	NOUN
hjic-1161	161	31	engineering	engineering	NOUN
hjic-1161	161	32	.	.	PUNCT
hjic-1161	162	1	6	6	X
hjic-1161	162	2	.	.	X
hjic-1161	162	3	conclusions	conclusion	NOUN
hjic-1161	162	4	enzyme	enzyme	NOUN
hjic-1161	162	5	reaction	reaction	NOUN
hjic-1161	162	6	engineering	engineering	NOUN
hjic-1161	162	7	can	can	AUX
hjic-1161	162	8	provide	provide	VERB
hjic-1161	162	9	explanations	explanation	NOUN
hjic-1161	162	10	for	for	ADP
hjic-1161	162	11	and	and	CCONJ
hjic-1161	162	12	give	give	VERB
hjic-1161	162	13	answers	answer	NOUN
hjic-1161	162	14	to	to	ADP
hjic-1161	162	15	different	different	ADJ
hjic-1161	162	16	phenomena	phenomenon	NOUN
hjic-1161	162	17	that	that	PRON
hjic-1161	162	18	occur	occur	VERB
hjic-1161	162	19	in	in	ADP
hjic-1161	162	20	bioreactors	bioreactor	NOUN
hjic-1161	162	21	.	.	PUNCT
hjic-1161	163	1	this	this	PRON
hjic-1161	163	2	is	be	AUX
hjic-1161	163	3	of	of	ADP
hjic-1161	163	4	particular	particular	ADJ
hjic-1161	163	5	importance	importance	NOUN
hjic-1161	163	6	when	when	SCONJ
hjic-1161	163	7	it	it	PRON
hjic-1161	163	8	comes	come	VERB
hjic-1161	163	9	to	to	ADP
hjic-1161	163	10	multienzyme	multienzyme	NOUN
hjic-1161	163	11	systems	system	NOUN
hjic-1161	163	12	which	which	PRON
hjic-1161	163	13	are	be	AUX
hjic-1161	163	14	very	very	ADV
hjic-1161	163	15	important	important	ADJ
hjic-1161	163	16	in	in	ADP
hjic-1161	163	17	terms	term	NOUN
hjic-1161	163	18	of	of	ADP
hjic-1161	163	19	sustainable	sustainable	ADJ
hjic-1161	163	20	development	development	NOUN
hjic-1161	163	21	and	and	CCONJ
hjic-1161	163	22	green	green	ADJ
hjic-1161	163	23	synthesis	synthesis	NOUN
hjic-1161	163	24	.	.	PUNCT
hjic-1161	164	1	many	many	ADJ
hjic-1161	164	2	obstacles	obstacle	NOUN
hjic-1161	164	3	to	to	ADP
hjic-1161	164	4	their	their	PRON
hjic-1161	164	5	development	development	NOUN
hjic-1161	164	6	must	must	AUX
hjic-1161	164	7	be	be	AUX
hjic-1161	164	8	overcome	overcome	VERB
hjic-1161	164	9	,	,	PUNCT
hjic-1161	164	10	for	for	ADP
hjic-1161	164	11	example	example	NOUN
hjic-1161	164	12	,	,	PUNCT
hjic-1161	164	13	adjusting	adjust	VERB
hjic-1161	164	14	enzyme	enzyme	NOUN
hjic-1161	164	15	activities	activity	NOUN
hjic-1161	164	16	,	,	PUNCT
hjic-1161	164	17	choosing	choose	VERB
hjic-1161	164	18	suitable	suitable	ADJ
hjic-1161	164	19	enzyme	enzyme	NOUN
hjic-1161	164	20	variants	variant	NOUN
hjic-1161	164	21	,	,	PUNCT
hjic-1161	164	22	selecting	select	VERB
hjic-1161	164	23	the	the	DET
hjic-1161	164	24	best	good	ADJ
hjic-1161	164	25	reactor	reactor	NOUN
hjic-1161	164	26	and	and	CCONJ
hjic-1161	164	27	determining	determine	VERB
hjic-1161	164	28	the	the	DET
hjic-1161	164	29	optimal	optimal	ADJ
hjic-1161	164	30	reaction	reaction	NOUN
hjic-1161	164	31	conditions	condition	NOUN
hjic-1161	164	32	while	while	SCONJ
hjic-1161	164	33	considering	consider	VERB
hjic-1161	164	34	the	the	DET
hjic-1161	164	35	side	side	NOUN
hjic-1161	164	36	reactions	reaction	NOUN
hjic-1161	164	37	that	that	PRON
hjic-1161	164	38	may	may	AUX
hjic-1161	164	39	occur	occur	VERB
hjic-1161	164	40	.	.	PUNCT
hjic-1161	165	1	therefore	therefore	ADV
hjic-1161	165	2	,	,	PUNCT
hjic-1161	165	3	a	a	DET
hjic-1161	165	4	combined	combine	VERB
hjic-1161	165	5	effort	effort	NOUN
hjic-1161	165	6	and	and	CCONJ
hjic-1161	165	7	multidisciplinary	multidisciplinary	ADJ
hjic-1161	165	8	approach	approach	NOUN
hjic-1161	165	9	are	be	AUX
hjic-1161	165	10	required	require	VERB
hjic-1161	165	11	to	to	PART
hjic-1161	165	12	prepare	prepare	VERB
hjic-1161	165	13	complex	complex	ADJ
hjic-1161	165	14	enzyme	enzyme	NOUN
hjic-1161	165	15	reaction	reaction	NOUN
hjic-1161	165	16	systems	system	NOUN
hjic-1161	165	17	for	for	ADP
hjic-1161	165	18	industrial	industrial	ADJ
hjic-1161	165	19	applications	application	NOUN
hjic-1161	165	20	.	.	PUNCT
hjic-1161	166	1	acknowledgement	acknowledgement	NOUN
hjic-1161	166	2	authors	author	NOUN
hjic-1161	166	3	would	would	AUX
hjic-1161	166	4	like	like	VERB
hjic-1161	166	5	to	to	PART
hjic-1161	166	6	thank	thank	VERB
hjic-1161	166	7	the	the	DET
hjic-1161	166	8	croatian	croatian	PROPN
hjic-1161	166	9	science	science	PROPN
hjic-1161	166	10	foundation	foundation	PROPN
hjic-1161	166	11	for	for	ADP
hjic-1161	166	12	the	the	DET
hjic-1161	166	13	phd	phd	NOUN
hjic-1161	166	14	scholarship	scholarship	NOUN
hjic-1161	166	15	of	of	ADP
hjic-1161	166	16	n.	n.	PROPN
hjic-1161	166	17	milčić.	milčić.	PROPN
hjic-1161	166	18	this	this	DET
hjic-1161	166	19	work	work	NOUN
hjic-1161	166	20	was	be	AUX
hjic-1161	166	21	partly	partly	ADV
hjic-1161	166	22	supported	support	VERB
hjic-1161	166	23	by	by	ADP
hjic-1161	166	24	the	the	DET
hjic-1161	166	25	project	project	NOUN
hjic-1161	166	26	cat	cat	NOUN
hjic-1161	166	27	pharma	pharma	PROPN
hjic-1161	166	28	(	(	PUNCT
hjic-1161	166	29	kk.01.1.1.04.0013	kk.01.1.1.04.0013	PROPN
hjic-1161	166	30	)	)	PUNCT
hjic-1161	166	31	co	co	VERB
hjic-1161	166	32	-	-	VERB
hjic-1161	166	33	financed	finance	VERB
hjic-1161	166	34	by	by	ADP
hjic-1161	166	35	the	the	DET
hjic-1161	166	36	croatian	croatian	ADJ
hjic-1161	166	37	government	government	NOUN
hjic-1161	166	38	and	and	CCONJ
hjic-1161	166	39	the	the	DET
hjic-1161	166	40	european	european	PROPN
hjic-1161	166	41	union	union	PROPN
hjic-1161	166	42	through	through	ADP
hjic-1161	166	43	the	the	DET
hjic-1161	166	44	european	european	PROPN
hjic-1161	166	45	regional	regional	PROPN
hjic-1161	166	46	development	development	PROPN
hjic-1161	166	47	fund	fund	NOUN
hjic-1161	166	48	the	the	DET
hjic-1161	166	49	competitiveness	competitiveness	NOUN
hjic-1161	166	50	and	and	CCONJ
hjic-1161	166	51	cohesion	cohesion	NOUN
hjic-1161	166	52	operational	operational	ADJ
hjic-1161	166	53	programme	programme	NOUN
hjic-1161	166	54	(	(	PUNCT
hjic-1161	166	55	i.	i.	NOUN
hjic-1161	166	56	ćevid	ćevid	PROPN
hjic-1161	166	57	)	)	PUNCT
hjic-1161	166	58	.	.	PUNCT
hjic-1161	167	1	we	we	PRON
hjic-1161	167	2	acknowledge	acknowledge	VERB
hjic-1161	167	3	the	the	DET
hjic-1161	167	4	funding	funding	NOUN
hjic-1161	167	5	from	from	ADP
hjic-1161	167	6	eu	eu	PROPN
hjic-1161	167	7	h2020	h2020	PROPN
hjic-1161	167	8	-	-	PUNCT
hjic-1161	167	9	msca	msca	NOUN
hjic-1161	167	10	-	-	PUNCT
hjic-1161	167	11	itn2020	itn2020	NOUN
hjic-1161	167	12	project	project	NOUN
hjic-1161	167	13	c	c	NOUN
hjic-1161	167	14	-	-	PUNCT
hjic-1161	167	15	c	c	NOUN
hjic-1161	167	16	top	top	NOUN
hjic-1161	167	17	under	under	ADP
hjic-1161	167	18	the	the	DET
hjic-1161	167	19	grant	grant	NOUN
hjic-1161	167	20	agreement	agreement	NOUN
hjic-1161	167	21	no	no	INTJ
hjic-1161	167	22	.	.	PUNCT
hjic-1161	168	1	956631	956631	NUM
hjic-1161	168	2	(	(	PUNCT
hjic-1161	168	3	m.	m.	NOUN
hjic-1161	168	4	m.	m.	PROPN
hjic-1161	168	5	çakar	çakar	PROPN
hjic-1161	168	6	)	)	PUNCT
hjic-1161	168	7	.	.	PUNCT
hjic-1161	169	1	references	reference	NOUN
hjic-1161	169	2	[	[	X
hjic-1161	169	3	1	1	NUM
hjic-1161	169	4	]	]	X
hjic-1161	169	5	burgess	burgess	NOUN
hjic-1161	169	6	,	,	PUNCT
hjic-1161	169	7	r.r	r.r	PROPN
hjic-1161	169	8	.	.	PROPN
hjic-1161	169	9	;	;	PUNCT
hjic-1161	170	1	deutscher	deutscher	PROPN
hjic-1161	170	2	,	,	PUNCT
hjic-1161	170	3	m.p	m.p	PROPN
hjic-1161	170	4	.	.	PUNCT
hjic-1161	170	5	:	:	PUNCT
hjic-1161	170	6	guide	guide	VERB
hjic-1161	170	7	to	to	ADP
hjic-1161	170	8	protein	protein	NOUN
hjic-1161	170	9	purification	purification	NOUN
hjic-1161	170	10	(	(	PUNCT
hjic-1161	170	11	academic	academic	ADJ
hjic-1161	170	12	press	press	NOUN
hjic-1161	170	13	,	,	PUNCT
hjic-1161	170	14	cambridge	cambridge	PROPN
hjic-1161	170	15	,	,	PUNCT
hjic-1161	170	16	uk	uk	PROPN
hjic-1161	170	17	)	)	PUNCT
hjic-1161	170	18	,	,	PUNCT
hjic-1161	170	19	2nd	2nd	PROPN
hjic-1161	170	20	edition	edition	NOUN
hjic-1161	170	21	,	,	PUNCT
hjic-1161	170	22	2009	2009	NUM
hjic-1161	170	23	,	,	PUNCT
hjic-1161	170	24	isbn	isbn	ADJ
hjic-1161	170	25	:	:	PUNCT
hjic-1161	170	26	978	978	NUM
hjic-1161	170	27	-	-	SYM
hjic-1161	170	28	008	008	NUM
hjic-1161	170	29	-	-	PUNCT
hjic-1161	170	30	092	092	NUM
hjic-1161	170	31	-	-	PUNCT
hjic-1161	170	32	317	317	NUM
hjic-1161	170	33	-	-	SYM
hjic-1161	170	34	8	8	NUM
hjic-1161	170	35	[	[	SYM
hjic-1161	170	36	2	2	NUM
hjic-1161	170	37	]	]	X
hjic-1161	170	38	robinson	robinson	PROPN
hjic-1161	170	39	,	,	PUNCT
hjic-1161	170	40	p.k	p.k	PROPN
hjic-1161	170	41	.	.	PUNCT
hjic-1161	170	42	:	:	PUNCT
hjic-1161	171	1	enzymes	enzyme	NOUN
hjic-1161	171	2	:	:	PUNCT
hjic-1161	171	3	principles	principle	NOUN
hjic-1161	171	4	and	and	CCONJ
hjic-1161	171	5	biotechnological	biotechnological	ADJ
hjic-1161	171	6	applications	application	NOUN
hjic-1161	171	7	,	,	PUNCT
hjic-1161	171	8	essays	essay	NOUN
hjic-1161	171	9	biochem	biochem	PROPN
hjic-1161	171	10	,	,	PUNCT
hjic-1161	171	11	2015	2015	NUM
hjic-1161	171	12	,	,	PUNCT
hjic-1161	171	13	59	59	NUM
hjic-1161	171	14	,	,	PUNCT
hjic-1161	171	15	1–41	1–41	NOUN
hjic-1161	171	16	.	.	PUNCT
hjic-1161	172	1	doi	doi	NOUN
hjic-1161	172	2	:	:	PUNCT
hjic-1161	172	3	10.1042	10.1042	NUM
hjic-1161	172	4	/	/	SYM
hjic-1161	172	5	bse0590001	bse0590001	NOUN
hjic-1161	172	6	[	[	X
hjic-1161	172	7	3	3	NUM
hjic-1161	172	8	]	]	PUNCT
hjic-1161	172	9	bisswanger	bisswanger	NOUN
hjic-1161	172	10	,	,	PUNCT
hjic-1161	172	11	h.	h.	NOUN
hjic-1161	172	12	:	:	PUNCT
hjic-1161	172	13	enzyme	enzyme	NOUN
hjic-1161	172	14	kinetics	kinetic	NOUN
hjic-1161	172	15	:	:	PUNCT
hjic-1161	172	16	principles	principle	NOUN
hjic-1161	172	17	and	and	CCONJ
hjic-1161	172	18	methods	method	NOUN
hjic-1161	172	19	(	(	PUNCT
hjic-1161	172	20	wiley	wiley	PROPN
hjic-1161	172	21	,	,	PUNCT
hjic-1161	172	22	new	new	PROPN
hjic-1161	172	23	york	york	PROPN
hjic-1161	172	24	,	,	PUNCT
hjic-1161	172	25	usa	usa	PROPN
hjic-1161	172	26	)	)	PUNCT
hjic-1161	172	27	,	,	PUNCT
hjic-1161	172	28	3rd	3rd	NOUN
hjic-1161	172	29	edition	edition	NOUN
hjic-1161	172	30	,	,	PUNCT
hjic-1161	172	31	2017	2017	NUM
hjic-1161	172	32	isbn	isbn	NOUN
hjic-1161	172	33	:	:	PUNCT
hjic-1161	172	34	978	978	NUM
hjic-1161	172	35	-	-	SYM
hjic-1161	172	36	352	352	NUM
hjic-1161	172	37	-	-	PUNCT
hjic-1161	172	38	780	780	NUM
hjic-1161	172	39	-	-	PUNCT
hjic-1161	172	40	646	646	NUM
hjic-1161	172	41	-	-	SYM
hjic-1161	172	42	1	1	NUM
hjic-1161	172	43	[	[	X
hjic-1161	172	44	4	4	NUM
hjic-1161	172	45	]	]	PUNCT
hjic-1161	172	46	siedentop	siedentop	NOUN
hjic-1161	172	47	,	,	PUNCT
hjic-1161	172	48	r.	r.	PROPN
hjic-1161	172	49	;	;	PUNCT
hjic-1161	172	50	claaßen	claaßen	PROPN
hjic-1161	172	51	,	,	PUNCT
hjic-1161	172	52	c.	c.	NOUN
hjic-1161	172	53	;	;	PUNCT
hjic-1161	172	54	rother	rother	PROPN
hjic-1161	172	55	,	,	PUNCT
hjic-1161	172	56	d.	d.	PROPN
hjic-1161	172	57	;	;	PUNCT
hjic-1161	172	58	lütz	lütz	PROPN
hjic-1161	172	59	,	,	PUNCT
hjic-1161	172	60	s.	s.	PROPN
hjic-1161	172	61	;	;	PUNCT
hjic-1161	172	62	rosenthal	rosenthal	PROPN
hjic-1161	172	63	,	,	PUNCT
hjic-1161	172	64	k.	k.	PROPN
hjic-1161	172	65	:	:	PUNCT
hjic-1161	172	66	getting	get	VERB
hjic-1161	172	67	the	the	DET
hjic-1161	172	68	most	most	ADJ
hjic-1161	172	69	out	out	ADP
hjic-1161	172	70	of	of	ADP
hjic-1161	172	71	enzyme	enzyme	NOUN
hjic-1161	172	72	cascades	cascade	NOUN
hjic-1161	172	73	:	:	PUNCT
hjic-1161	172	74	strategies	strategy	NOUN
hjic-1161	172	75	to	to	PART
hjic-1161	172	76	optimize	optimize	VERB
hjic-1161	172	77	in	in	ADP
hjic-1161	172	78	vitro	vitro	X
hjic-1161	172	79	multienzymatic	multienzymatic	ADJ
hjic-1161	172	80	reactions	reaction	NOUN
hjic-1161	172	81	,	,	PUNCT
hjic-1161	172	82	catalysts	catalyst	NOUN
hjic-1161	172	83	,	,	PUNCT
hjic-1161	172	84	2021	2021	NUM
hjic-1161	172	85	,	,	PUNCT
hjic-1161	172	86	11(10	11(10	NUM
hjic-1161	172	87	)	)	PUNCT
hjic-1161	172	88	,	,	PUNCT
hjic-1161	172	89	1183	1183	NUM
hjic-1161	172	90	doi	doi	NOUN
hjic-1161	172	91	:	:	PUNCT
hjic-1161	172	92	10.3390	10.3390	NUM
hjic-1161	172	93	/	/	SYM
hjic-1161	172	94	catal11101183	catal11101183	PROPN
hjic-1161	173	1	[	[	X
hjic-1161	173	2	5	5	NUM
hjic-1161	173	3	]	]	PUNCT
hjic-1161	173	4	komáromy	komáromy	NOUN
hjic-1161	173	5	,	,	PUNCT
hjic-1161	173	6	p.	p.	NOUN
hjic-1161	173	7	;	;	PUNCT
hjic-1161	173	8	bélafi	bélafi	PROPN
hjic-1161	173	9	-	-	PUNCT
hjic-1161	173	10	bakó	bakó	PROPN
hjic-1161	173	11	,	,	PUNCT
hjic-1161	173	12	k.	k.	PROPN
hjic-1161	173	13	;	;	PUNCT
hjic-1161	173	14	hülber	hülber	PROPN
hjic-1161	173	15	-	-	PUNCT
hjic-1161	173	16	beyer	beyer	PROPN
hjic-1161	173	17	,	,	PUNCT
hjic-1161	173	18	é	é	PROPN
hjic-1161	173	19	.	.	PUNCT
hjic-1161	173	20	;	;	PUNCT
hjic-1161	173	21	nemestóthy	nemestóthy	ADJ
hjic-1161	173	22	,	,	PUNCT
hjic-1161	173	23	n.	n.	NOUN
hjic-1161	173	24	:	:	PUNCT
hjic-1161	173	25	enhancement	enhancement	NOUN
hjic-1161	173	26	of	of	ADP
hjic-1161	173	27	oxygen	oxygen	NOUN
hjic-1161	173	28	transfer	transfer	NOUN
hjic-1161	173	29	through	through	ADP
hjic-1161	173	30	membranes	membrane	NOUN
hjic-1161	173	31	in	in	ADP
hjic-1161	173	32	bioprocesses	bioprocesse	NOUN
hjic-1161	173	33	,	,	PUNCT
hjic-1161	173	34	hung	hung	PROPN
hjic-1161	173	35	.	.	PUNCT
hjic-1161	174	1	j.	j.	PROPN
hjic-1161	174	2	ind	ind	PROPN
hjic-1161	174	3	.	.	PUNCT
hjic-1161	175	1	chem	chem	PROPN
hjic-1161	175	2	.	.	PUNCT
hjic-1161	175	3	,	,	PUNCT
hjic-1161	175	4	2020	2020	NUM
hjic-1161	175	5	,	,	PUNCT
hjic-1161	175	6	48(2	48(2	NUM
hjic-1161	175	7	)	)	PUNCT
hjic-1161	175	8	,	,	PUNCT
hjic-1161	175	9	5–8	5–8	PROPN
hjic-1161	175	10	doi	doi	NOUN
hjic-1161	175	11	:	:	PUNCT
hjic-1161	175	12	10.33927	10.33927	NUM
hjic-1161	175	13	/	/	SYM
hjic-1161	175	14	hjic-2020	hjic-2020	NOUN
hjic-1161	175	15	-	-	PUNCT
hjic-1161	175	16	21	21	NUM
hjic-1161	175	17	50	50	NUM
hjic-1161	175	18	pp	pp	NOUN
hjic-1161	175	19	.	.	PUNCT
hjic-1161	176	1	45–55	45–55	NUM
hjic-1161	176	2	(	(	PUNCT
hjic-1161	176	3	2022	2022	NUM
hjic-1161	176	4	)	)	PUNCT
hjic-1161	176	5	https://doi.org/10.1042/bse0590001	https://doi.org/10.1042/bse0590001	NOUN
hjic-1161	176	6	https://doi.org/10.3390/catal11101183	https://doi.org/10.3390/catal11101183	NOUN
hjic-1161	176	7	https://doi.org/10.33927/hjic-2020-21	https://doi.org/10.33927/hjic-2020-21	X
hjic-1161	176	8	54	54	NUM
hjic-1161	176	9	milčić	milčić	PROPN
hjic-1161	176	10	,	,	PUNCT
hjic-1161	176	11	ćevid	ćevid	PROPN
hjic-1161	176	12	,	,	PUNCT
hjic-1161	176	13	çakar	çakar	NOUN
hjic-1161	176	14	,	,	PUNCT
hjic-1161	176	15	sudar	sudar	ADJ
hjic-1161	176	16	and	and	CCONJ
hjic-1161	176	17	findrik	findrik	VERB
hjic-1161	176	18	blažević	blažević	PUNCT
hjic-1161	177	1	[	[	X
hjic-1161	177	2	6	6	NUM
hjic-1161	177	3	]	]	PUNCT
hjic-1161	177	4	schallmey	schallmey	NOUN
hjic-1161	177	5	,	,	PUNCT
hjic-1161	177	6	a.	a.	NOUN
hjic-1161	177	7	;	;	PUNCT
hjic-1161	177	8	schallmey	schallmey	ADJ
hjic-1161	177	9	,	,	PUNCT
hjic-1161	177	10	m.	m.	NOUN
hjic-1161	177	11	:	:	PUNCT
hjic-1161	177	12	recent	recent	ADJ
hjic-1161	177	13	advances	advance	NOUN
hjic-1161	177	14	on	on	ADP
hjic-1161	177	15	halohydrin	halohydrin	NOUN
hjic-1161	177	16	dehalogenases	dehalogenase	NOUN
hjic-1161	177	17	–	–	PUNCT
hjic-1161	177	18	from	from	ADP
hjic-1161	177	19	enzyme	enzyme	NOUN
hjic-1161	177	20	identification	identification	NOUN
hjic-1161	177	21	to	to	ADP
hjic-1161	177	22	novel	novel	ADJ
hjic-1161	177	23	biocatalytic	biocatalytic	ADJ
hjic-1161	177	24	applications	application	NOUN
hjic-1161	177	25	,	,	PUNCT
hjic-1161	177	26	appl	appl	PROPN
hjic-1161	177	27	.	.	PUNCT
hjic-1161	177	28	microbiol	microbiol	PROPN
hjic-1161	177	29	.	.	PUNCT
hjic-1161	178	1	biotechnol	biotechnol	PROPN
hjic-1161	178	2	.	.	PUNCT
hjic-1161	178	3	,	,	PUNCT
hjic-1161	178	4	2016	2016	NUM
hjic-1161	178	5	,	,	PUNCT
hjic-1161	178	6	100(18	100(18	NUM
hjic-1161	178	7	)	)	PUNCT
hjic-1161	178	8	,	,	PUNCT
hjic-1161	178	9	7827–7839	7827–7839	NUM
hjic-1161	178	10	doi	doi	NOUN
hjic-1161	178	11	:	:	PUNCT
hjic-1161	178	12	10.1007	10.1007	NUM
hjic-1161	178	13	/	/	SYM
hjic-1161	178	14	s00253	s00253	NOUN
hjic-1161	178	15	-	-	PUNCT
hjic-1161	178	16	016	016	NUM
hjic-1161	178	17	-	-	PUNCT
hjic-1161	178	18	7750	7750	NUM
hjic-1161	178	19	-	-	SYM
hjic-1161	178	20	y	y	NOUN
hjic-1161	179	1	[	[	X
hjic-1161	179	2	7	7	NUM
hjic-1161	179	3	]	]	X
hjic-1161	179	4	gonzález	gonzález	PROPN
hjic-1161	179	5	-	-	PUNCT
hjic-1161	179	6	pérez	pérez	NOUN
hjic-1161	179	7	,	,	PUNCT
hjic-1161	179	8	m.	m.	NOUN
hjic-1161	179	9	;	;	PUNCT
hjic-1161	179	10	gómez	gómez	NOUN
hjic-1161	179	11	-	-	PUNCT
hjic-1161	179	12	bombarelli	bombarelli	PROPN
hjic-1161	179	13	,	,	PUNCT
hjic-1161	179	14	r.	r.	PROPN
hjic-1161	179	15	;	;	PUNCT
hjic-1161	179	16	arenas	arenas	PROPN
hjic-1161	179	17	-	-	PUNCT
hjic-1161	179	18	valgańón	valgańón	PROPN
hjic-1161	179	19	,	,	PUNCT
hjic-1161	179	20	j.	j.	PROPN
hjic-1161	179	21	;	;	PUNCT
hjic-1161	179	22	pérez	pérez	NOUN
hjic-1161	179	23	-	-	PUNCT
hjic-1161	179	24	prior	prior	ADJ
hjic-1161	179	25	,	,	PUNCT
hjic-1161	179	26	m.t	m.t	PROPN
hjic-1161	179	27	.	.	PROPN
hjic-1161	179	28	;	;	PUNCT
hjic-1161	179	29	garcíasantos	garcíasantos	ADV
hjic-1161	179	30	,	,	PUNCT
hjic-1161	179	31	m.p	m.p	PROPN
hjic-1161	179	32	.	.	PROPN
hjic-1161	179	33	;	;	PUNCT
hjic-1161	179	34	calle	calle	PROPN
hjic-1161	179	35	,	,	PUNCT
hjic-1161	179	36	e.	e.	PROPN
hjic-1161	179	37	;	;	PUNCT
hjic-1161	179	38	casado	casado	PROPN
hjic-1161	179	39	,	,	PUNCT
hjic-1161	179	40	j.	j.	PROPN
hjic-1161	179	41	:	:	PUNCT
hjic-1161	179	42	connecting	connect	VERB
hjic-1161	179	43	the	the	DET
hjic-1161	179	44	chemical	chemical	ADJ
hjic-1161	179	45	and	and	CCONJ
hjic-1161	179	46	biological	biological	ADJ
hjic-1161	179	47	reactivity	reactivity	NOUN
hjic-1161	179	48	of	of	ADP
hjic-1161	179	49	epoxides	epoxide	NOUN
hjic-1161	179	50	,	,	PUNCT
hjic-1161	179	51	chem	chem	NOUN
hjic-1161	179	52	.	.	PUNCT
hjic-1161	180	1	res	re	NOUN
hjic-1161	180	2	.	.	PUNCT
hjic-1161	181	1	toxicol	toxicol	PROPN
hjic-1161	181	2	.	.	PUNCT
hjic-1161	181	3	,	,	PUNCT
hjic-1161	181	4	2012	2012	NUM
hjic-1161	181	5	,	,	PUNCT
hjic-1161	181	6	25(12	25(12	NUM
hjic-1161	181	7	)	)	PUNCT
hjic-1161	181	8	,	,	PUNCT
hjic-1161	181	9	2755–2762	2755–2762	NUM
hjic-1161	181	10	doi	doi	NOUN
hjic-1161	181	11	:	:	PUNCT
hjic-1161	181	12	10.1021	10.1021	NUM
hjic-1161	181	13	/	/	SYM
hjic-1161	181	14	tx300389z	tx300389z	PUNCT
hjic-1161	182	1	[	[	X
hjic-1161	182	2	8	8	NUM
hjic-1161	182	3	]	]	X
hjic-1161	182	4	lee	lee	PROPN
hjic-1161	182	5	,	,	PUNCT
hjic-1161	182	6	e.y	e.y	PROPN
hjic-1161	182	7	.	.	PROPN
hjic-1161	182	8	:	:	PUNCT
hjic-1161	182	9	enantioselective	enantioselective	ADJ
hjic-1161	182	10	hydrolysis	hydrolysis	NOUN
hjic-1161	182	11	of	of	ADP
hjic-1161	182	12	epichlorohydrin	epichlorohydrin	NOUN
hjic-1161	182	13	in	in	ADP
hjic-1161	182	14	organic	organic	ADJ
hjic-1161	182	15	solvents	solvent	NOUN
hjic-1161	182	16	using	use	VERB
hjic-1161	182	17	recombinant	recombinant	ADJ
hjic-1161	182	18	epoxide	epoxide	NOUN
hjic-1161	182	19	hydrolase	hydrolase	NOUN
hjic-1161	182	20	,	,	PUNCT
hjic-1161	182	21	j.	j.	PROPN
hjic-1161	182	22	ind	ind	PROPN
hjic-1161	182	23	.	.	PUNCT
hjic-1161	183	1	eng	eng	PROPN
hjic-1161	183	2	.	.	PROPN
hjic-1161	183	3	chem	chem	PROPN
hjic-1161	183	4	.	.	PUNCT
hjic-1161	183	5	,	,	PUNCT
hjic-1161	183	6	2007	2007	NUM
hjic-1161	183	7	,	,	PUNCT
hjic-1161	183	8	13(1	13(1	NUM
hjic-1161	183	9	)	)	PUNCT
hjic-1161	183	10	,	,	PUNCT
hjic-1161	183	11	159	159	NUM
hjic-1161	183	12	–	–	PUNCT
hjic-1161	183	13	162	162	NUM
hjic-1161	183	14	https://www.cheric.org	https://www.cheric.org	X
hjic-1161	184	1	[	[	X
hjic-1161	184	2	9	9	NUM
hjic-1161	184	3	]	]	X
hjic-1161	184	4	jin	jin	NOUN
hjic-1161	184	5	,	,	PUNCT
hjic-1161	184	6	h.x	h.x	PROPN
hjic-1161	184	7	.	.	PROPN
hjic-1161	184	8	;	;	PUNCT
hjic-1161	185	1	liu	liu	PROPN
hjic-1161	185	2	,	,	PUNCT
hjic-1161	185	3	z.q	z.q	PROPN
hjic-1161	185	4	.	.	PROPN
hjic-1161	185	5	;	;	PUNCT
hjic-1161	185	6	hu	hu	PROPN
hjic-1161	185	7	,	,	PUNCT
hjic-1161	185	8	z.c	z.c	PROPN
hjic-1161	185	9	.	.	PROPN
hjic-1161	185	10	;	;	PUNCT
hjic-1161	185	11	zheng	zheng	PROPN
hjic-1161	185	12	,	,	PUNCT
hjic-1161	185	13	y.g	y.g	PROPN
hjic-1161	185	14	.	.	PUNCT
hjic-1161	185	15	:	:	PUNCT
hjic-1161	185	16	production	production	NOUN
hjic-1161	185	17	of	of	ADP
hjic-1161	185	18	(	(	PUNCT
hjic-1161	185	19	r)-epichlorohydrin	r)-epichlorohydrin	PROPN
hjic-1161	185	20	from	from	ADP
hjic-1161	185	21	1,3	1,3	NUM
hjic-1161	185	22	-	-	PUNCT
hjic-1161	185	23	dichloro2	dichloro2	NOUN
hjic-1161	185	24	-	-	PUNCT
hjic-1161	185	25	propanol	propanol	NOUN
hjic-1161	185	26	by	by	ADP
hjic-1161	185	27	two	two	NUM
hjic-1161	185	28	-	-	PUNCT
hjic-1161	185	29	step	step	NOUN
hjic-1161	185	30	biocatalysis	biocatalysis	NOUN
hjic-1161	185	31	using	use	VERB
hjic-1161	185	32	haloalcohol	haloalcohol	NOUN
hjic-1161	185	33	dehalogenase	dehalogenase	NOUN
hjic-1161	185	34	and	and	CCONJ
hjic-1161	185	35	epoxide	epoxide	NOUN
hjic-1161	185	36	hydrolase	hydrolase	NOUN
hjic-1161	185	37	in	in	ADP
hjic-1161	185	38	twophase	twophase	NOUN
hjic-1161	185	39	system	system	NOUN
hjic-1161	185	40	,	,	PUNCT
hjic-1161	185	41	biochem	biochem	PROPN
hjic-1161	185	42	.	.	PUNCT
hjic-1161	186	1	eng	eng	PROPN
hjic-1161	186	2	.	.	PUNCT
hjic-1161	187	1	j.	j.	PROPN
hjic-1161	187	2	,	,	PUNCT
hjic-1161	187	3	2013	2013	NUM
hjic-1161	187	4	,	,	PUNCT
hjic-1161	187	5	74	74	NUM
hjic-1161	187	6	,	,	PUNCT
hjic-1161	187	7	1–7	1–7	NUM
hjic-1161	187	8	doi	doi	NOUN
hjic-1161	187	9	:	:	PUNCT
hjic-1161	187	10	10.1016	10.1016	NUM
hjic-1161	187	11	/	/	SYM
hjic-1161	187	12	j.bej.2013.02.005	j.bej.2013.02.005	VERB
hjic-1161	188	1	[	[	X
hjic-1161	188	2	10	10	NUM
hjic-1161	188	3	]	]	X
hjic-1161	188	4	watanabe	watanabe	PROPN
hjic-1161	188	5	,	,	PUNCT
hjic-1161	188	6	f.	f.	PROPN
hjic-1161	188	7	;	;	PUNCT
hjic-1161	188	8	yu	yu	PROPN
hjic-1161	188	9	,	,	PUNCT
hjic-1161	188	10	f.	f.	PROPN
hjic-1161	188	11	;	;	PUNCT
hjic-1161	188	12	ohtaki	ohtaki	PROPN
hjic-1161	188	13	,	,	PUNCT
hjic-1161	188	14	a.	a.	NOUN
hjic-1161	188	15	;	;	PUNCT
hjic-1161	188	16	yamanaka	yamanaka	PROPN
hjic-1161	188	17	,	,	PUNCT
hjic-1161	188	18	y.	y.	PROPN
hjic-1161	188	19	;	;	PUNCT
hjic-1161	188	20	noguchi	noguchi	PROPN
hjic-1161	188	21	,	,	PUNCT
hjic-1161	188	22	k.	k.	PROPN
hjic-1161	188	23	;	;	PUNCT
hjic-1161	188	24	odaka	odaka	PROPN
hjic-1161	188	25	,	,	PUNCT
hjic-1161	188	26	m.	m.	NOUN
hjic-1161	188	27	;	;	PUNCT
hjic-1161	188	28	yohda	yohda	ADJ
hjic-1161	188	29	,	,	PUNCT
hjic-1161	188	30	m.	m.	NOUN
hjic-1161	188	31	:	:	PUNCT
hjic-1161	188	32	improvement	improvement	NOUN
hjic-1161	188	33	of	of	ADP
hjic-1161	188	34	enantioselectivity	enantioselectivity	NOUN
hjic-1161	188	35	of	of	ADP
hjic-1161	188	36	the	the	DET
hjic-1161	188	37	b	b	NOUN
hjic-1161	188	38	-	-	PUNCT
hjic-1161	188	39	type	type	NOUN
hjic-1161	188	40	halohydrin	halohydrin	NOUN
hjic-1161	188	41	hydrogen	hydrogen	NOUN
hjic-1161	188	42	-	-	PUNCT
hjic-1161	188	43	halide	halide	NOUN
hjic-1161	188	44	-	-	PUNCT
hjic-1161	188	45	lyase	lyase	NOUN
hjic-1161	188	46	from	from	ADP
hjic-1161	188	47	corynebacterium	corynebacterium	NOUN
hjic-1161	188	48	sp	sp	PROPN
hjic-1161	188	49	.	.	PUNCT
hjic-1161	189	1	n-1074	n-1074	PROPN
hjic-1161	189	2	,	,	PUNCT
hjic-1161	189	3	j.	j.	PROPN
hjic-1161	189	4	biosci	biosci	PROPN
hjic-1161	189	5	.	.	PUNCT
hjic-1161	190	1	bioeng	bioeng	PROPN
hjic-1161	190	2	.	.	PROPN
hjic-1161	190	3	,	,	PUNCT
hjic-1161	190	4	2016	2016	NUM
hjic-1161	190	5	,	,	PUNCT
hjic-1161	190	6	122(3	122(3	NUM
hjic-1161	190	7	)	)	PUNCT
hjic-1161	190	8	,	,	PUNCT
hjic-1161	190	9	270	270	NUM
hjic-1161	190	10	–	–	PUNCT
hjic-1161	190	11	275	275	NUM
hjic-1161	190	12	doi	doi	NOUN
hjic-1161	190	13	:	:	PUNCT
hjic-1161	190	14	10.1016	10.1016	NUM
hjic-1161	190	15	/	/	SYM
hjic-1161	190	16	j.jbiosc.2016.02.003	j.jbiosc.2016.02.003	PROPN
hjic-1161	191	1	[	[	X
hjic-1161	191	2	11	11	NUM
hjic-1161	191	3	]	]	SYM
hjic-1161	191	4	yao	yao	NOUN
hjic-1161	191	5	,	,	PUNCT
hjic-1161	191	6	p.	p.	PROPN
hjic-1161	191	7	;	;	PUNCT
hjic-1161	191	8	wang	wang	PROPN
hjic-1161	191	9	,	,	PUNCT
hjic-1161	191	10	l.	l.	PROPN
hjic-1161	191	11	;	;	PUNCT
hjic-1161	191	12	yuan	yuan	PROPN
hjic-1161	191	13	,	,	PUNCT
hjic-1161	191	14	j.	j.	PROPN
hjic-1161	191	15	;	;	PUNCT
hjic-1161	191	16	cheng	cheng	PROPN
hjic-1161	191	17	,	,	PUNCT
hjic-1161	191	18	l.	l.	PROPN
hjic-1161	191	19	;	;	PUNCT
hjic-1161	191	20	jia	jia	PROPN
hjic-1161	191	21	,	,	PUNCT
hjic-1161	191	22	r.	r.	PROPN
hjic-1161	191	23	;	;	PUNCT
hjic-1161	191	24	xie	xie	PROPN
hjic-1161	191	25	,	,	PUNCT
hjic-1161	191	26	m.	m.	NOUN
hjic-1161	191	27	;	;	PUNCT
hjic-1161	191	28	feng	feng	PROPN
hjic-1161	191	29	,	,	PUNCT
hjic-1161	191	30	j.	j.	PROPN
hjic-1161	191	31	;	;	PUNCT
hjic-1161	191	32	wang	wang	PROPN
hjic-1161	191	33	,	,	PUNCT
hjic-1161	191	34	m.	m.	NOUN
hjic-1161	191	35	;	;	PUNCT
hjic-1161	191	36	wu	wu	PROPN
hjic-1161	191	37	,	,	PUNCT
hjic-1161	191	38	q.	q.	PROPN
hjic-1161	191	39	;	;	PUNCT
hjic-1161	191	40	zhu	zhu	PROPN
hjic-1161	191	41	,	,	PUNCT
hjic-1161	191	42	d.	d.	PROPN
hjic-1161	191	43	:	:	PUNCT
hjic-1161	191	44	efficient	efficient	ADJ
hjic-1161	191	45	biosynthesis	biosynthesis	NOUN
hjic-1161	191	46	of	of	ADP
hjic-1161	191	47	ethyl	ethyl	PROPN
hjic-1161	191	48	(	(	PUNCT
hjic-1161	191	49	r)-3	r)-3	PROPN
hjic-1161	191	50	-	-	NOUN
hjic-1161	191	51	hydroxyglutarate	hydroxyglutarate	NOUN
hjic-1161	191	52	through	through	ADP
hjic-1161	191	53	a	a	DET
hjic-1161	191	54	one	one	NUM
hjic-1161	191	55	-	-	PUNCT
hjic-1161	191	56	pot	pot	NOUN
hjic-1161	191	57	bienzymatic	bienzymatic	ADJ
hjic-1161	191	58	cascade	cascade	NOUN
hjic-1161	191	59	of	of	ADP
hjic-1161	191	60	halohydrin	halohydrin	NOUN
hjic-1161	191	61	dehalogenase	dehalogenase	NOUN
hjic-1161	191	62	and	and	CCONJ
hjic-1161	191	63	nitrilase	nitrilase	NOUN
hjic-1161	191	64	,	,	PUNCT
hjic-1161	191	65	chemcatchem	chemcatchem	NOUN
hjic-1161	191	66	,	,	PUNCT
hjic-1161	191	67	2015	2015	NUM
hjic-1161	191	68	,	,	PUNCT
hjic-1161	191	69	7(9	7(9	NUM
hjic-1161	191	70	)	)	PUNCT
hjic-1161	191	71	,	,	PUNCT
hjic-1161	191	72	1438–1444	1438–1444	NUM
hjic-1161	191	73	doi	doi	NOUN
hjic-1161	191	74	:	:	PUNCT
hjic-1161	191	75	10.1002	10.1002	NUM
hjic-1161	191	76	/	/	SYM
hjic-1161	191	77	cctc.201500061	cctc.201500061	PROPN
hjic-1161	192	1	[	[	X
hjic-1161	192	2	12	12	NUM
hjic-1161	192	3	]	]	PUNCT
hjic-1161	192	4	findrik	findrik	NOUN
hjic-1161	192	5	blažević	blažević	PROPN
hjic-1161	192	6	,	,	PUNCT
hjic-1161	192	7	z.	z.	PROPN
hjic-1161	192	8	;	;	PUNCT
hjic-1161	192	9	milčić	milčić	ADJ
hjic-1161	192	10	,	,	PUNCT
hjic-1161	192	11	n.	n.	NOUN
hjic-1161	192	12	;	;	PUNCT
hjic-1161	192	13	sudar	sudar	ADJ
hjic-1161	192	14	,	,	PUNCT
hjic-1161	192	15	m.	m.	NOUN
hjic-1161	192	16	;	;	PUNCT
hjic-1161	192	17	majerić	majerić	X
hjic-1161	193	1	elenkov	elenkov	NOUN
hjic-1161	193	2	,	,	PUNCT
hjic-1161	193	3	m.	m.	NOUN
hjic-1161	193	4	:	:	PUNCT
hjic-1161	193	5	halohydrin	halohydrin	NOUN
hjic-1161	193	6	dehalogenases	dehalogenase	NOUN
hjic-1161	193	7	and	and	CCONJ
hjic-1161	193	8	their	their	PRON
hjic-1161	193	9	potential	potential	NOUN
hjic-1161	193	10	in	in	ADP
hjic-1161	193	11	industrial	industrial	ADJ
hjic-1161	193	12	application	application	NOUN
hjic-1161	193	13	–	–	PUNCT
hjic-1161	193	14	a	a	DET
hjic-1161	193	15	viewpoint	viewpoint	NOUN
hjic-1161	193	16	of	of	ADP
hjic-1161	193	17	enzyme	enzyme	NOUN
hjic-1161	193	18	reaction	reaction	NOUN
hjic-1161	193	19	engineering	engineering	NOUN
hjic-1161	193	20	,	,	PUNCT
hjic-1161	193	21	adv	adv	PROPN
hjic-1161	193	22	.	.	PUNCT
hjic-1161	193	23	synth	synth	PROPN
hjic-1161	193	24	.	.	PUNCT
hjic-1161	194	1	catal	catal	PROPN
hjic-1161	194	2	.	.	PROPN
hjic-1161	194	3	,	,	PUNCT
hjic-1161	194	4	2021	2021	NUM
hjic-1161	194	5	,	,	PUNCT
hjic-1161	194	6	363(2	363(2	NUM
hjic-1161	194	7	)	)	PUNCT
hjic-1161	194	8	,	,	PUNCT
hjic-1161	194	9	388–410	388–410	NUM
hjic-1161	194	10	doi	doi	NOUN
hjic-1161	194	11	:	:	PUNCT
hjic-1161	194	12	10.1002	10.1002	NUM
hjic-1161	194	13	/	/	SYM
hjic-1161	194	14	adsc.202000984	adsc.202000984	PROPN
hjic-1161	195	1	[	[	X
hjic-1161	195	2	13	13	NUM
hjic-1161	195	3	]	]	X
hjic-1161	195	4	ringborg	ringborg	NOUN
hjic-1161	195	5	,	,	PUNCT
hjic-1161	195	6	r.h	r.h	PROPN
hjic-1161	195	7	.	.	PROPN
hjic-1161	195	8	;	;	PUNCT
hjic-1161	195	9	woodley	woodley	NOUN
hjic-1161	195	10	,	,	PUNCT
hjic-1161	195	11	j.m	j.m	PROPN
hjic-1161	195	12	.	.	PROPN
hjic-1161	195	13	:	:	PUNCT
hjic-1161	196	1	the	the	DET
hjic-1161	196	2	application	application	NOUN
hjic-1161	196	3	of	of	ADP
hjic-1161	196	4	reaction	reaction	NOUN
hjic-1161	196	5	engineering	engineering	NOUN
hjic-1161	196	6	to	to	ADP
hjic-1161	196	7	biocatalysis	biocatalysis	NOUN
hjic-1161	196	8	,	,	PUNCT
hjic-1161	196	9	react	react	VERB
hjic-1161	196	10	.	.	PUNCT
hjic-1161	197	1	chem	chem	NOUN
hjic-1161	197	2	.	.	PUNCT
hjic-1161	198	1	eng	eng	PROPN
hjic-1161	198	2	.	.	PROPN
hjic-1161	198	3	,	,	PUNCT
hjic-1161	198	4	2016	2016	NUM
hjic-1161	198	5	,	,	PUNCT
hjic-1161	198	6	1(1	1(1	NUM
hjic-1161	198	7	)	)	PUNCT
hjic-1161	198	8	,	,	PUNCT
hjic-1161	198	9	10–22	10–22	NUM
hjic-1161	198	10	doi	doi	NOUN
hjic-1161	198	11	:	:	PUNCT
hjic-1161	198	12	10.1039	10.1039	NUM
hjic-1161	198	13	/	/	SYM
hjic-1161	198	14	c5re00045a	c5re00045a	PROPN
hjic-1161	198	15	[	[	X
hjic-1161	198	16	14	14	NUM
hjic-1161	198	17	]	]	X
hjic-1161	198	18	švarc	švarc	NOUN
hjic-1161	198	19	,	,	PUNCT
hjic-1161	198	20	a.	a.	NOUN
hjic-1161	198	21	;	;	PUNCT
hjic-1161	198	22	fekete	fekete	PROPN
hjic-1161	198	23	,	,	PUNCT
hjic-1161	198	24	m.	m.	NOUN
hjic-1161	198	25	;	;	PUNCT
hjic-1161	198	26	hernandez	hernandez	PROPN
hjic-1161	198	27	,	,	PUNCT
hjic-1161	198	28	k.	k.	PROPN
hjic-1161	198	29	;	;	PUNCT
hjic-1161	198	30	clapés	clapé	NOUN
hjic-1161	198	31	,	,	PUNCT
hjic-1161	198	32	p.	p.	NOUN
hjic-1161	198	33	;	;	PUNCT
hjic-1161	198	34	findrik	findrik	PROPN
hjic-1161	198	35	blažević	blažević	PROPN
hjic-1161	198	36	,	,	PUNCT
hjic-1161	198	37	z.	z.	PROPN
hjic-1161	198	38	;	;	PUNCT
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hjic-1161	198	40	,	,	PUNCT
hjic-1161	198	41	a.	a.	NOUN
hjic-1161	198	42	;	;	PUNCT
hjic-1161	198	43	skendrović	skendrović	PROPN
hjic-1161	198	44	,	,	PUNCT
hjic-1161	198	45	d.	d.	PROPN
hjic-1161	198	46	;	;	PUNCT
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hjic-1161	198	48	,	,	PUNCT
hjic-1161	198	49	ð	ð	PROPN
hjic-1161	198	50	.	.	PUNCT
hjic-1161	198	51	;	;	PUNCT
hjic-1161	198	52	charnock	charnock	PROPN
hjic-1161	198	53	,	,	PUNCT
hjic-1161	198	54	s.j	s.j	PROPN
hjic-1161	198	55	.	.	PROPN
hjic-1161	198	56	;	;	PUNCT
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hjic-1161	198	58	presečki	presečki	PROPN
hjic-1161	198	59	,	,	PUNCT
hjic-1161	198	60	a.	a.	NOUN
hjic-1161	198	61	:	:	PUNCT
hjic-1161	198	62	an	an	DET
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hjic-1161	198	64	route	route	NOUN
hjic-1161	198	65	for	for	ADP
hjic-1161	198	66	the	the	DET
hjic-1161	198	67	production	production	NOUN
hjic-1161	198	68	of	of	ADP
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hjic-1161	198	70	side	side	NOUN
hjic-1161	198	71	-	-	PUNCT
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hjic-1161	198	73	precursor	precursor	NOUN
hjic-1161	198	74	by	by	ADP
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hjic-1161	198	76	double	double	ADJ
hjic-1161	198	77	aldol	aldol	NOUN
hjic-1161	198	78	addition	addition	NOUN
hjic-1161	198	79	,	,	PUNCT
hjic-1161	198	80	chem	chem	NOUN
hjic-1161	198	81	.	.	PUNCT
hjic-1161	199	1	eng	eng	PROPN
hjic-1161	199	2	.	.	PUNCT
hjic-1161	200	1	sci	sci	PROPN
hjic-1161	200	2	.	.	PROPN
hjic-1161	200	3	,	,	PUNCT
hjic-1161	200	4	2021	2021	NUM
hjic-1161	200	5	,	,	PUNCT
hjic-1161	200	6	231	231	NUM
hjic-1161	200	7	,	,	PUNCT
hjic-1161	200	8	116312	116312	NUM
hjic-1161	200	9	doi	doi	NOUN
hjic-1161	200	10	:	:	PUNCT
hjic-1161	200	11	10.1016	10.1016	NUM
hjic-1161	200	12	/	/	SYM
hjic-1161	200	13	j.ces.2020.116312	j.ces.2020.116312	PROPN
hjic-1161	201	1	[	[	X
hjic-1161	201	2	15	15	NUM
hjic-1161	201	3	]	]	X
hjic-1161	201	4	mattey	mattey	PROPN
hjic-1161	201	5	,	,	PUNCT
hjic-1161	201	6	a.p	a.p	PROPN
hjic-1161	201	7	.	.	PROPN
hjic-1161	201	8	;	;	PUNCT
hjic-1161	201	9	ford	ford	PROPN
hjic-1161	201	10	,	,	PUNCT
hjic-1161	201	11	g.j	g.j	PROPN
hjic-1161	201	12	.	.	PROPN
hjic-1161	201	13	;	;	PUNCT
hjic-1161	201	14	citoler	citoler	PROPN
hjic-1161	201	15	,	,	PUNCT
hjic-1161	201	16	j.	j.	PROPN
hjic-1161	201	17	;	;	PUNCT
hjic-1161	201	18	baldwin	baldwin	PROPN
hjic-1161	201	19	,	,	PUNCT
hjic-1161	201	20	c.	c.	PROPN
hjic-1161	201	21	;	;	PUNCT
hjic-1161	201	22	marshall	marshall	PROPN
hjic-1161	201	23	,	,	PUNCT
hjic-1161	201	24	j.r	j.r	PROPN
hjic-1161	201	25	.	.	PROPN
hjic-1161	201	26	;	;	PUNCT
hjic-1161	201	27	palmer	palmer	PROPN
hjic-1161	201	28	,	,	PUNCT
hjic-1161	201	29	r.b	r.b	PROPN
hjic-1161	201	30	.	.	PROPN
hjic-1161	201	31	;	;	PUNCT
hjic-1161	201	32	thompson	thompson	PROPN
hjic-1161	201	33	,	,	PUNCT
hjic-1161	201	34	m.	m.	NOUN
hjic-1161	201	35	;	;	PUNCT
hjic-1161	201	36	turner	turner	PROPN
hjic-1161	201	37	,	,	PUNCT
hjic-1161	201	38	n.j	n.j	PROPN
hjic-1161	201	39	.	.	PROPN
hjic-1161	201	40	;	;	PUNCT
hjic-1161	201	41	cosgrove	cosgrove	PROPN
hjic-1161	201	42	,	,	PUNCT
hjic-1161	201	43	s.	s.	PROPN
hjic-1161	201	44	;	;	PUNCT
hjic-1161	201	45	flitsch	flitsch	PROPN
hjic-1161	201	46	,	,	PUNCT
hjic-1161	201	47	s.l	s.l	PROPN
hjic-1161	201	48	.	.	PROPN
hjic-1161	201	49	:	:	PUNCT
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hjic-1161	201	51	of	of	ADP
hjic-1161	201	52	continuous	continuous	ADJ
hjic-1161	201	53	flow	flow	NOUN
hjic-1161	201	54	systems	system	NOUN
hjic-1161	201	55	to	to	PART
hjic-1161	201	56	access	access	VERB
hjic-1161	201	57	secondary	secondary	ADJ
hjic-1161	201	58	amines	amine	NOUN
hjic-1161	201	59	through	through	ADP
hjic-1161	201	60	previously	previously	ADV
hjic-1161	201	61	incompatible	incompatible	ADJ
hjic-1161	201	62	biocatalytic	biocatalytic	ADJ
hjic-1161	201	63	cascades	cascade	NOUN
hjic-1161	201	64	,	,	PUNCT
hjic-1161	201	65	angew	angew	NOUN
hjic-1161	201	66	.	.	PUNCT
hjic-1161	202	1	chem	chem	PROPN
hjic-1161	202	2	.	.	PUNCT
hjic-1161	203	1	int	int	NOUN
hjic-1161	203	2	.	.	PUNCT
hjic-1161	204	1	ed	ed	NOUN
hjic-1161	204	2	.	.	PROPN
hjic-1161	204	3	,	,	PUNCT
hjic-1161	204	4	2021	2021	NUM
hjic-1161	204	5	,	,	PUNCT
hjic-1161	204	6	60(34	60(34	NOUN
hjic-1161	204	7	)	)	PUNCT
hjic-1161	204	8	,	,	PUNCT
hjic-1161	204	9	18660–18665	18660–18665	NUM
hjic-1161	204	10	doi	doi	NOUN
hjic-1161	204	11	:	:	PUNCT
hjic-1161	204	12	10.1002	10.1002	NUM
hjic-1161	204	13	/	/	SYM
hjic-1161	204	14	anie.202103805	anie.202103805	PROPN
hjic-1161	205	1	[	[	X
hjic-1161	205	2	16	16	NUM
hjic-1161	205	3	]	]	X
hjic-1161	205	4	britton	britton	PROPN
hjic-1161	205	5	,	,	PUNCT
hjic-1161	205	6	j.	j.	PROPN
hjic-1161	205	7	;	;	PUNCT
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hjic-1161	205	9	,	,	PUNCT
hjic-1161	205	10	s.	s.	PROPN
hjic-1161	205	11	;	;	PUNCT
hjic-1161	205	12	weiss	weiss	PROPN
hjic-1161	205	13	,	,	PUNCT
hjic-1161	205	14	g.a	g.a	PROPN
hjic-1161	205	15	.	.	PUNCT
hjic-1161	205	16	:	:	PUNCT
hjic-1161	206	1	continuous	continuous	ADJ
hjic-1161	206	2	flow	flow	NOUN
hjic-1161	206	3	biocatalysis	biocatalysis	NOUN
hjic-1161	206	4	,	,	PUNCT
hjic-1161	206	5	chem	chem	NOUN
hjic-1161	206	6	.	.	PUNCT
hjic-1161	207	1	soc	soc	PROPN
hjic-1161	207	2	.	.	PUNCT
hjic-1161	208	1	rev	rev	PROPN
hjic-1161	208	2	.	.	PROPN
hjic-1161	208	3	,	,	PUNCT
hjic-1161	208	4	2018	2018	NUM
hjic-1161	208	5	,	,	PUNCT
hjic-1161	208	6	47(15	47(15	NOUN
hjic-1161	208	7	)	)	PUNCT
hjic-1161	208	8	,	,	PUNCT
hjic-1161	208	9	5891–5918	5891–5918	NUM
hjic-1161	208	10	doi	doi	NOUN
hjic-1161	208	11	:	:	PUNCT
hjic-1161	208	12	10.1039	10.1039	NUM
hjic-1161	208	13	/	/	SYM
hjic-1161	208	14	c7cs00906b	c7cs00906b	PROPN
hjic-1161	209	1	[	[	X
hjic-1161	209	2	17	17	NUM
hjic-1161	209	3	]	]	X
hjic-1161	209	4	klermund	klermund	PROPN
hjic-1161	209	5	,	,	PUNCT
hjic-1161	209	6	l.	l.	PROPN
hjic-1161	209	7	;	;	PUNCT
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hjic-1161	209	9	,	,	PUNCT
hjic-1161	209	10	s.t	s.t	PROPN
hjic-1161	209	11	.	.	PROPN
hjic-1161	209	12	;	;	PUNCT
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hjic-1161	209	14	,	,	PUNCT
hjic-1161	209	15	k.	k.	NOUN
hjic-1161	209	16	:	:	PUNCT
hjic-1161	209	17	biocatalysis	biocatalysis	NOUN
hjic-1161	209	18	in	in	ADP
hjic-1161	209	19	polymersomes	polymersome	NOUN
hjic-1161	209	20	:	:	PUNCT
hjic-1161	209	21	improving	improve	VERB
hjic-1161	209	22	multienzyme	multienzyme	NOUN
hjic-1161	209	23	cascades	cascade	VERB
hjic-1161	209	24	with	with	ADP
hjic-1161	209	25	incompatible	incompatible	ADJ
hjic-1161	209	26	reaction	reaction	NOUN
hjic-1161	209	27	steps	step	NOUN
hjic-1161	209	28	by	by	ADP
hjic-1161	209	29	compartmentalization	compartmentalization	NOUN
hjic-1161	209	30	,	,	PUNCT
hjic-1161	209	31	acs	acs	PROPN
hjic-1161	209	32	catal	catal	NOUN
hjic-1161	209	33	.	.	PROPN
hjic-1161	209	34	,	,	PUNCT
hjic-1161	209	35	2017	2017	NUM
hjic-1161	209	36	,	,	PUNCT
hjic-1161	209	37	7(6	7(6	NUM
hjic-1161	209	38	)	)	PUNCT
hjic-1161	209	39	,	,	PUNCT
hjic-1161	209	40	3900–3904	3900–3904	NUM
hjic-1161	209	41	doi	doi	NOUN
hjic-1161	209	42	:	:	PUNCT
hjic-1161	209	43	10.1021	10.1021	NUM
hjic-1161	209	44	/	/	SYM
hjic-1161	209	45	acscatal.7b00776	acscatal.7b00776	NOUN
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hjic-1161	210	2	18	18	NUM
hjic-1161	210	3	]	]	PUNCT
hjic-1161	210	4	schmidt	schmidt	PROPN
hjic-1161	210	5	,	,	PUNCT
hjic-1161	210	6	s.	s.	PROPN
hjic-1161	210	7	;	;	PUNCT
hjic-1161	210	8	castiglione	castiglione	PROPN
hjic-1161	210	9	,	,	PUNCT
hjic-1161	210	10	k.	k.	PROPN
hjic-1161	210	11	;	;	PUNCT
hjic-1161	210	12	kourist	kourist	PROPN
hjic-1161	210	13	,	,	PUNCT
hjic-1161	210	14	r.	r.	PROPN
hjic-1161	210	15	:	:	PUNCT
hjic-1161	210	16	overcoming	overcome	VERB
hjic-1161	210	17	the	the	DET
hjic-1161	210	18	incompatibility	incompatibility	NOUN
hjic-1161	210	19	challenge	challenge	NOUN
hjic-1161	210	20	in	in	ADP
hjic-1161	210	21	chemoenzymatic	chemoenzymatic	ADJ
hjic-1161	210	22	and	and	CCONJ
hjic-1161	210	23	multi	multi	ADJ
hjic-1161	210	24	-	-	ADJ
hjic-1161	210	25	catalytic	catalytic	ADJ
hjic-1161	210	26	cascade	cascade	NOUN
hjic-1161	210	27	reactions	reaction	NOUN
hjic-1161	210	28	,	,	PUNCT
hjic-1161	210	29	chem	chem	NOUN
hjic-1161	210	30	.	.	PUNCT
hjic-1161	211	1	eur	eur	PROPN
hjic-1161	211	2	.	.	PUNCT
hjic-1161	212	1	j.	j.	PROPN
hjic-1161	212	2	,	,	PUNCT
hjic-1161	212	3	2018	2018	NUM
hjic-1161	212	4	,	,	PUNCT
hjic-1161	212	5	24(8	24(8	NUM
hjic-1161	212	6	)	)	PUNCT
hjic-1161	212	7	,	,	PUNCT
hjic-1161	212	8	1755–1768	1755–1768	NUM
hjic-1161	212	9	doi	doi	NOUN
hjic-1161	212	10	:	:	PUNCT
hjic-1161	212	11	10.1002	10.1002	NUM
hjic-1161	212	12	/	/	SYM
hjic-1161	212	13	chem.201703353	chem.201703353	PROPN
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hjic-1161	213	2	19	19	NUM
hjic-1161	213	3	]	]	X
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hjic-1161	213	5	,	,	PUNCT
hjic-1161	213	6	j.	j.	PROPN
hjic-1161	213	7	;	;	PUNCT
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hjic-1161	213	9	,	,	PUNCT
hjic-1161	213	10	u.t	u.t	PROPN
hjic-1161	213	11	.	.	PROPN
hjic-1161	213	12	;	;	PUNCT
hjic-1161	213	13	kara	kara	PROPN
hjic-1161	213	14	,	,	PUNCT
hjic-1161	213	15	s.	s.	PROPN
hjic-1161	213	16	:	:	PUNCT
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hjic-1161	213	18	modeling	modeling	NOUN
hjic-1161	213	19	of	of	ADP
hjic-1161	213	20	a	a	DET
hjic-1161	213	21	convergent	convergent	NOUN
hjic-1161	213	22	cascade	cascade	NOUN
hjic-1161	213	23	catalyzed	catalyze	VERB
hjic-1161	213	24	by	by	ADP
hjic-1161	213	25	monooxygenase	monooxygenase	NOUN
hjic-1161	213	26	–	–	PUNCT
hjic-1161	213	27	alcohol	alcohol	NOUN
hjic-1161	213	28	dehydrogenase	dehydrogenase	NOUN
hjic-1161	213	29	coupled	couple	VERB
hjic-1161	213	30	enzymes	enzyme	NOUN
hjic-1161	213	31	,	,	PUNCT
hjic-1161	213	32	org	org	NOUN
hjic-1161	213	33	.	.	PUNCT
hjic-1161	213	34	process	process	NOUN
hjic-1161	213	35	res	re	NOUN
hjic-1161	213	36	.	.	PUNCT
hjic-1161	214	1	dev	dev	PROPN
hjic-1161	214	2	.	.	PROPN
hjic-1161	214	3	,	,	PUNCT
hjic-1161	214	4	2021	2021	NUM
hjic-1161	214	5	,	,	PUNCT
hjic-1161	214	6	25(3	25(3	NUM
hjic-1161	214	7	)	)	PUNCT
hjic-1161	214	8	,	,	PUNCT
hjic-1161	214	9	411–420	411–420	NUM
hjic-1161	214	10	doi	doi	NOUN
hjic-1161	214	11	:	:	PUNCT
hjic-1161	214	12	10.1021	10.1021	NUM
hjic-1161	214	13	/	/	SYM
hjic-1161	214	14	acs.oprd.0c00372	acs.oprd.0c00372	ADJ
hjic-1161	214	15	[	[	X
hjic-1161	214	16	20	20	NUM
hjic-1161	214	17	]	]	SYM
hjic-1161	214	18	vasić-rački	vasić-rački	NOUN
hjic-1161	214	19	,	,	PUNCT
hjic-1161	214	20	ð	ð	PROPN
hjic-1161	214	21	.	.	PUNCT
hjic-1161	214	22	;	;	PUNCT
hjic-1161	214	23	kragl	kragl	PROPN
hjic-1161	214	24	,	,	PUNCT
hjic-1161	214	25	u.	u.	PROPN
hjic-1161	214	26	;	;	PUNCT
hjic-1161	214	27	liese	liese	PROPN
hjic-1161	214	28	,	,	PUNCT
hjic-1161	214	29	a.	a.	NOUN
hjic-1161	214	30	:	:	PUNCT
hjic-1161	214	31	benefits	benefit	NOUN
hjic-1161	214	32	of	of	ADP
hjic-1161	214	33	enzyme	enzyme	NOUN
hjic-1161	214	34	kinetics	kinetic	NOUN
hjic-1161	214	35	modelling	modelling	NOUN
hjic-1161	214	36	,	,	PUNCT
hjic-1161	214	37	chem	chem	NOUN
hjic-1161	214	38	.	.	PUNCT
hjic-1161	215	1	biochem	biochem	PROPN
hjic-1161	215	2	.	.	PUNCT
hjic-1161	216	1	eng	eng	PROPN
hjic-1161	216	2	.	.	PROPN
hjic-1161	216	3	q.	q.	PROPN
hjic-1161	216	4	,	,	PUNCT
hjic-1161	216	5	2003	2003	NUM
hjic-1161	216	6	,	,	PUNCT
hjic-1161	216	7	17(1	17(1	NUM
hjic-1161	216	8	)	)	PUNCT
hjic-1161	216	9	,	,	PUNCT
hjic-1161	216	10	7–18	7–18	NUM
hjic-1161	216	11	http://silverstripe.fkit.hr	http://silverstripe.fkit.hr	PROPN
hjic-1161	216	12	[	[	X
hjic-1161	216	13	21	21	NUM
hjic-1161	216	14	]	]	SYM
hjic-1161	216	15	česnik	česnik	X
hjic-1161	216	16	,	,	PUNCT
hjic-1161	216	17	m.	m.	NOUN
hjic-1161	216	18	;	;	PUNCT
hjic-1161	216	19	sudar	sudar	NOUN
hjic-1161	216	20	,	,	PUNCT
hjic-1161	216	21	m.	m.	NOUN
hjic-1161	216	22	;	;	PUNCT
hjic-1161	216	23	hernández	hernández	PROPN
hjic-1161	216	24	,	,	PUNCT
hjic-1161	216	25	k.	k.	PROPN
hjic-1161	216	26	;	;	PUNCT
hjic-1161	216	27	charnock	charnock	PROPN
hjic-1161	216	28	,	,	PUNCT
hjic-1161	216	29	s.	s.	PROPN
hjic-1161	216	30	;	;	PUNCT
hjic-1161	216	31	vasić-rački	vasić-rački	NOUN
hjic-1161	216	32	,	,	PUNCT
hjic-1161	216	33	ð	ð	PROPN
hjic-1161	216	34	.	.	PUNCT
hjic-1161	216	35	;	;	PUNCT
hjic-1161	216	36	clapés	clapé	NOUN
hjic-1161	216	37	,	,	PUNCT
hjic-1161	216	38	p.	p.	NOUN
hjic-1161	216	39	;	;	PUNCT
hjic-1161	216	40	findrik	findrik	PROPN
hjic-1161	216	41	blažević	blažević	PROPN
hjic-1161	216	42	,	,	PUNCT
hjic-1161	216	43	z.	z.	PROPN
hjic-1161	216	44	:	:	PUNCT
hjic-1161	216	45	cascade	cascade	NOUN
hjic-1161	216	46	enzymatic	enzymatic	ADJ
hjic-1161	216	47	synthesis	synthesis	NOUN
hjic-1161	216	48	of	of	ADP
hjic-1161	216	49	l	l	NOUN
hjic-1161	216	50	-	-	NOUN
hjic-1161	216	51	homoserine	homoserine	NOUN
hjic-1161	216	52	–	–	PUNCT
hjic-1161	216	53	mathematical	mathematical	ADJ
hjic-1161	216	54	modelling	modelling	NOUN
hjic-1161	216	55	as	as	ADP
hjic-1161	216	56	a	a	DET
hjic-1161	216	57	tool	tool	NOUN
hjic-1161	216	58	for	for	ADP
hjic-1161	216	59	process	process	NOUN
hjic-1161	216	60	optimisation	optimisation	NOUN
hjic-1161	216	61	and	and	CCONJ
hjic-1161	216	62	design	design	NOUN
hjic-1161	216	63	,	,	PUNCT
hjic-1161	216	64	react	react	ADJ
hjic-1161	216	65	.	.	PUNCT
hjic-1161	217	1	chem	chem	NOUN
hjic-1161	217	2	.	.	PUNCT
hjic-1161	218	1	eng	eng	PROPN
hjic-1161	218	2	.	.	PROPN
hjic-1161	218	3	,	,	PUNCT
hjic-1161	218	4	2020	2020	NUM
hjic-1161	218	5	,	,	PUNCT
hjic-1161	218	6	5(4	5(4	NUM
hjic-1161	218	7	)	)	PUNCT
hjic-1161	218	8	,	,	PUNCT
hjic-1161	218	9	747–759	747–759	PROPN
hjic-1161	218	10	doi	doi	NOUN
hjic-1161	218	11	:	:	PUNCT
hjic-1161	218	12	10.1039	10.1039	NUM
hjic-1161	218	13	/	/	SYM
hjic-1161	219	1	c9re00453j	c9re00453j	PROPN
hjic-1161	219	2	[	[	X
hjic-1161	219	3	22	22	NUM
hjic-1161	219	4	]	]	PUNCT
hjic-1161	219	5	hernández	hernández	PROPN
hjic-1161	219	6	,	,	PUNCT
hjic-1161	219	7	k.	k.	PROPN
hjic-1161	219	8	;	;	PUNCT
hjic-1161	219	9	gómez	gómez	NOUN
hjic-1161	219	10	,	,	PUNCT
hjic-1161	219	11	a.	a.	NOUN
hjic-1161	219	12	;	;	PUNCT
hjic-1161	219	13	joglar	joglar	PROPN
hjic-1161	219	14	,	,	PUNCT
hjic-1161	219	15	j.	j.	PROPN
hjic-1161	219	16	;	;	PUNCT
hjic-1161	219	17	bujons	bujon	NOUN
hjic-1161	219	18	,	,	PUNCT
hjic-1161	219	19	j.	j.	PROPN
hjic-1161	219	20	;	;	PUNCT
hjic-1161	219	21	parella	parella	NOUN
hjic-1161	219	22	,	,	PUNCT
hjic-1161	219	23	t.	t.	PROPN
hjic-1161	219	24	;	;	PUNCT
hjic-1161	219	25	clapés	clapé	NOUN
hjic-1161	219	26	,	,	PUNCT
hjic-1161	219	27	p.	p.	NOUN
hjic-1161	219	28	:	:	PUNCT
hjic-1161	219	29	2	2	NUM
hjic-1161	219	30	-	-	PUNCT
hjic-1161	219	31	keto-3	keto-3	NOUN
hjic-1161	219	32	-	-	PUNCT
hjic-1161	219	33	deoxy	deoxy	VERB
hjic-1161	219	34	-	-	PUNCT
hjic-1161	219	35	lrhamnonate	lrhamnonate	NOUN
hjic-1161	219	36	aldolase	aldolase	NOUN
hjic-1161	219	37	(	(	PUNCT
hjic-1161	219	38	yfau	yfau	PROPN
hjic-1161	219	39	)	)	PUNCT
hjic-1161	219	40	as	as	ADP
hjic-1161	219	41	catalyst	catalyst	NOUN
hjic-1161	219	42	in	in	ADP
hjic-1161	219	43	aldol	aldol	NOUN
hjic-1161	219	44	additions	addition	NOUN
hjic-1161	219	45	of	of	ADP
hjic-1161	219	46	pyruvate	pyruvate	NOUN
hjic-1161	219	47	to	to	ADP
hjic-1161	219	48	amino	amino	ADJ
hjic-1161	219	49	aldehyde	aldehyde	NOUN
hjic-1161	219	50	derivatives	derivative	NOUN
hjic-1161	219	51	,	,	PUNCT
hjic-1161	219	52	adv	adv	PROPN
hjic-1161	219	53	.	.	PUNCT
hjic-1161	219	54	synth	synth	PROPN
hjic-1161	219	55	.	.	PUNCT
hjic-1161	220	1	catal	catal	PROPN
hjic-1161	220	2	.	.	PROPN
hjic-1161	220	3	,	,	PUNCT
hjic-1161	220	4	2017	2017	NUM
hjic-1161	220	5	,	,	PUNCT
hjic-1161	220	6	359(12	359(12	NUM
hjic-1161	220	7	)	)	PUNCT
hjic-1161	220	8	,	,	PUNCT
hjic-1161	220	9	2090–2100	2090–2100	NUM
hjic-1161	220	10	doi	doi	NOUN
hjic-1161	220	11	:	:	PUNCT
hjic-1161	220	12	10.1002	10.1002	NUM
hjic-1161	220	13	/	/	SYM
hjic-1161	220	14	adsc.201700360	adsc.201700360	PROPN
hjic-1161	221	1	[	[	X
hjic-1161	221	2	23	23	NUM
hjic-1161	221	3	]	]	X
hjic-1161	221	4	dong	dong	PROPN
hjic-1161	221	5	,	,	PUNCT
hjic-1161	221	6	j.	j.	PROPN
hjic-1161	221	7	;	;	PUNCT
hjic-1161	221	8	fernández	fernández	PROPN
hjic-1161	221	9	-	-	PUNCT
hjic-1161	221	10	fueyo	fueyo	NOUN
hjic-1161	221	11	,	,	PUNCT
hjic-1161	221	12	e.	e.	PROPN
hjic-1161	221	13	;	;	PUNCT
hjic-1161	221	14	hollmann	hollmann	PROPN
hjic-1161	221	15	,	,	PUNCT
hjic-1161	221	16	f.	f.	PROPN
hjic-1161	221	17	;	;	PUNCT
hjic-1161	221	18	paul	paul	PROPN
hjic-1161	221	19	,	,	PUNCT
hjic-1161	221	20	c.e	c.e	PROPN
hjic-1161	221	21	.	.	PROPN
hjic-1161	221	22	;	;	PUNCT
hjic-1161	221	23	pesic	pesic	ADJ
hjic-1161	221	24	,	,	PUNCT
hjic-1161	221	25	m.	m.	NOUN
hjic-1161	221	26	;	;	PUNCT
hjic-1161	221	27	schmidt	schmidt	PROPN
hjic-1161	221	28	,	,	PUNCT
hjic-1161	221	29	s.	s.	PROPN
hjic-1161	221	30	;	;	PUNCT
hjic-1161	221	31	wang	wang	PROPN
hjic-1161	221	32	,	,	PUNCT
hjic-1161	221	33	y.	y.	PROPN
hjic-1161	221	34	;	;	PUNCT
hjic-1161	221	35	younes	younes	PROPN
hjic-1161	221	36	,	,	PUNCT
hjic-1161	221	37	s.	s.	PROPN
hjic-1161	221	38	;	;	PUNCT
hjic-1161	221	39	zhang	zhang	PROPN
hjic-1161	221	40	,	,	PUNCT
hjic-1161	221	41	w.	w.	PROPN
hjic-1161	221	42	:	:	PUNCT
hjic-1161	221	43	biocatalytic	biocatalytic	ADJ
hjic-1161	221	44	oxidation	oxidation	NOUN
hjic-1161	221	45	reactions	reaction	NOUN
hjic-1161	221	46	:	:	PUNCT
hjic-1161	221	47	a	a	DET
hjic-1161	221	48	chemist	chemist	NOUN
hjic-1161	221	49	’s	’s	PART
hjic-1161	221	50	perspective	perspective	NOUN
hjic-1161	221	51	,	,	PUNCT
hjic-1161	221	52	angew	angew	NOUN
hjic-1161	221	53	.	.	PUNCT
hjic-1161	222	1	chem	chem	PROPN
hjic-1161	222	2	.	.	PUNCT
hjic-1161	223	1	int	int	NOUN
hjic-1161	223	2	.	.	PUNCT
hjic-1161	224	1	ed	ed	NOUN
hjic-1161	224	2	.	.	PROPN
hjic-1161	224	3	,	,	PUNCT
hjic-1161	224	4	2018	2018	NUM
hjic-1161	224	5	,	,	PUNCT
hjic-1161	224	6	57(30	57(30	NUM
hjic-1161	224	7	)	)	PUNCT
hjic-1161	224	8	,	,	PUNCT
hjic-1161	224	9	9238–9261	9238–9261	NUM
hjic-1161	224	10	doi	doi	NOUN
hjic-1161	224	11	:	:	PUNCT
hjic-1161	224	12	10.1002	10.1002	NUM
hjic-1161	224	13	/	/	SYM
hjic-1161	224	14	anie.201800343	anie.201800343	PROPN
hjic-1161	224	15	[	[	X
hjic-1161	224	16	24	24	NUM
hjic-1161	224	17	]	]	SYM
hjic-1161	224	18	toney	toney	PROPN
hjic-1161	224	19	,	,	PUNCT
hjic-1161	224	20	m.d	m.d	PROPN
hjic-1161	224	21	.	.	PUNCT
hjic-1161	224	22	:	:	PUNCT
hjic-1161	225	1	reaction	reaction	NOUN
hjic-1161	225	2	specificity	specificity	NOUN
hjic-1161	225	3	in	in	ADP
hjic-1161	225	4	pyridoxal	pyridoxal	ADJ
hjic-1161	225	5	phosphate	phosphate	ADJ
hjic-1161	225	6	enzymes	enzyme	NOUN
hjic-1161	225	7	,	,	PUNCT
hjic-1161	225	8	arch	arch	NOUN
hjic-1161	225	9	.	.	PUNCT
hjic-1161	226	1	biochem	biochem	PROPN
hjic-1161	226	2	.	.	PUNCT
hjic-1161	227	1	biophys	biophy	NOUN
hjic-1161	227	2	.	.	PUNCT
hjic-1161	227	3	,	,	PUNCT
hjic-1161	227	4	2005	2005	NUM
hjic-1161	227	5	,	,	PUNCT
hjic-1161	227	6	433(1	433(1	NUM
hjic-1161	227	7	)	)	PUNCT
hjic-1161	227	8	,	,	PUNCT
hjic-1161	227	9	279–287	279–287	NUM
hjic-1161	227	10	doi	doi	NOUN
hjic-1161	227	11	:	:	PUNCT
hjic-1161	227	12	10.1016	10.1016	NUM
hjic-1161	227	13	/	/	SYM
hjic-1161	227	14	j.abb.2004.09.037	j.abb.2004.09.037	PROPN
hjic-1161	228	1	[	[	X
hjic-1161	228	2	25	25	NUM
hjic-1161	228	3	]	]	X
hjic-1161	228	4	sudar	sudar	NOUN
hjic-1161	228	5	,	,	PUNCT
hjic-1161	228	6	m.	m.	NOUN
hjic-1161	228	7	;	;	PUNCT
hjic-1161	228	8	findrik	findrik	NOUN
hjic-1161	228	9	,	,	PUNCT
hjic-1161	228	10	z.	z.	PROPN
hjic-1161	228	11	;	;	PUNCT
hjic-1161	228	12	vasić-rački	vasić-rački	NOUN
hjic-1161	228	13	,	,	PUNCT
hjic-1161	228	14	ð	ð	PROPN
hjic-1161	228	15	.	.	PUNCT
hjic-1161	228	16	;	;	PUNCT
hjic-1161	229	1	soler	soler	PROPN
hjic-1161	229	2	,	,	PUNCT
hjic-1161	229	3	a.	a.	NOUN
hjic-1161	229	4	;	;	PUNCT
hjic-1161	229	5	clapés	clapé	NOUN
hjic-1161	229	6	,	,	PUNCT
hjic-1161	229	7	p.	p.	NOUN
hjic-1161	229	8	:	:	PUNCT
hjic-1161	229	9	a	a	DET
hjic-1161	229	10	new	new	ADJ
hjic-1161	229	11	concept	concept	NOUN
hjic-1161	229	12	for	for	ADP
hjic-1161	229	13	production	production	NOUN
hjic-1161	229	14	of	of	ADP
hjic-1161	229	15	(	(	PUNCT
hjic-1161	229	16	3s,4r)-6-[(benzyloxycarbonyl)amino]-5,6dideoxyhex-2	3s,4r)-6-[(benzyloxycarbonyl)amino]-5,6dideoxyhex-2	NUM
hjic-1161	229	17	-	-	PUNCT
hjic-1161	229	18	ulose	ulose	ADJ
hjic-1161	229	19	,	,	PUNCT
hjic-1161	229	20	a	a	DET
hjic-1161	229	21	precursor	precursor	NOUN
hjic-1161	229	22	of	of	ADP
hjic-1161	229	23	d	d	NOUN
hjic-1161	229	24	-	-	NOUN
hjic-1161	229	25	fagomine	fagomine	ADJ
hjic-1161	229	26	,	,	PUNCT
hjic-1161	229	27	rsc	rsc	PROPN
hjic-1161	229	28	adv	adv	PROPN
hjic-1161	229	29	.	.	PROPN
hjic-1161	229	30	,	,	PUNCT
hjic-1161	229	31	2015	2015	NUM
hjic-1161	229	32	,	,	PUNCT
hjic-1161	229	33	5(85	5(85	NUM
hjic-1161	229	34	)	)	PUNCT
hjic-1161	229	35	,	,	PUNCT
hjic-1161	229	36	69819–69828	69819–69828	NUM
hjic-1161	229	37	doi	doi	NOUN
hjic-1161	229	38	:	:	PUNCT
hjic-1161	229	39	10.1039	10.1039	NUM
hjic-1161	229	40	/	/	SYM
hjic-1161	229	41	c5ra14414k	c5ra14414k	PROPN
hjic-1161	229	42	[	[	X
hjic-1161	229	43	26	26	NUM
hjic-1161	229	44	]	]	X
hjic-1161	229	45	sudar	sudar	NOUN
hjic-1161	229	46	,	,	PUNCT
hjic-1161	229	47	m.	m.	NOUN
hjic-1161	229	48	;	;	PUNCT
hjic-1161	229	49	česnik	česnik	X
hjic-1161	229	50	,	,	PUNCT
hjic-1161	229	51	m.	m.	NOUN
hjic-1161	229	52	;	;	PUNCT
hjic-1161	229	53	clapés	clapé	NOUN
hjic-1161	229	54	,	,	PUNCT
hjic-1161	229	55	p.	p.	NOUN
hjic-1161	229	56	;	;	PUNCT
hjic-1161	229	57	pohl	pohl	PROPN
hjic-1161	229	58	,	,	PUNCT
hjic-1161	229	59	m.	m.	NOUN
hjic-1161	229	60	;	;	PUNCT
hjic-1161	229	61	vasićrački	vasićrački	PROPN
hjic-1161	229	62	,	,	PUNCT
hjic-1161	229	63	ð	ð	PROPN
hjic-1161	229	64	.	.	PUNCT
hjic-1161	229	65	;	;	PUNCT
hjic-1161	229	66	findrik	findrik	VERB
hjic-1161	229	67	blažević	blažević	PROPN
hjic-1161	229	68	,	,	PUNCT
hjic-1161	229	69	z.	z.	PROPN
hjic-1161	229	70	:	:	PUNCT
hjic-1161	230	1	a	a	DET
hjic-1161	230	2	cascade	cascade	NOUN
hjic-1161	230	3	reaction	reaction	NOUN
hjic-1161	230	4	for	for	ADP
hjic-1161	230	5	the	the	DET
hjic-1161	230	6	synthesis	synthesis	NOUN
hjic-1161	230	7	of	of	ADP
hjic-1161	230	8	d	d	ADJ
hjic-1161	230	9	-	-	ADJ
hjic-1161	230	10	fagomine	fagomine	ADJ
hjic-1161	230	11	precursor	precursor	NOUN
hjic-1161	230	12	revisited	revisit	VERB
hjic-1161	230	13	:	:	PUNCT
hjic-1161	230	14	kinetic	kinetic	ADJ
hjic-1161	230	15	insight	insight	NOUN
hjic-1161	230	16	and	and	CCONJ
hjic-1161	230	17	understanding	understanding	NOUN
hjic-1161	230	18	of	of	ADP
hjic-1161	230	19	the	the	DET
hjic-1161	230	20	system	system	NOUN
hjic-1161	230	21	,	,	PUNCT
hjic-1161	230	22	n.	n.	PROPN
hjic-1161	230	23	biotechnol	biotechnol	NOUN
hjic-1161	230	24	.	.	PUNCT
hjic-1161	230	25	,	,	PUNCT
hjic-1161	230	26	2021	2021	NUM
hjic-1161	230	27	,	,	PUNCT
hjic-1161	230	28	63	63	NUM
hjic-1161	230	29	,	,	PUNCT
hjic-1161	230	30	19–28	19–28	NUM
hjic-1161	230	31	doi	doi	NOUN
hjic-1161	230	32	:	:	PUNCT
hjic-1161	230	33	10.1016	10.1016	NUM
hjic-1161	230	34	/	/	SYM
hjic-1161	230	35	j.nbt.2021.02.004	j.nbt.2021.02.004	NOUN
hjic-1161	230	36	[	[	X
hjic-1161	230	37	27	27	NUM
hjic-1161	230	38	]	]	X
hjic-1161	230	39	sudar	sudar	NOUN
hjic-1161	230	40	,	,	PUNCT
hjic-1161	230	41	m.	m.	NOUN
hjic-1161	230	42	;	;	PUNCT
hjic-1161	230	43	vasić-rački	vasić-rački	NOUN
hjic-1161	230	44	,	,	PUNCT
hjic-1161	230	45	ð	ð	PROPN
hjic-1161	230	46	.	.	PUNCT
hjic-1161	230	47	;	;	PUNCT
hjic-1161	230	48	müller	müller	PROPN
hjic-1161	230	49	,	,	PUNCT
hjic-1161	230	50	m.	m.	NOUN
hjic-1161	230	51	;	;	PUNCT
hjic-1161	230	52	walter	walter	PROPN
hjic-1161	230	53	,	,	PUNCT
hjic-1161	230	54	a.	a.	PROPN
hjic-1161	230	55	;	;	PUNCT
hjic-1161	230	56	findrik	findrik	NOUN
hjic-1161	230	57	blažević	blažević	PROPN
hjic-1161	230	58	,	,	PUNCT
hjic-1161	230	59	z.	z.	PROPN
hjic-1161	230	60	:	:	PUNCT
hjic-1161	230	61	mathematical	mathematical	ADJ
hjic-1161	230	62	model	model	NOUN
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hjic-1161	230	65	mend	mend	ADV
hjic-1161	230	66	-	-	PUNCT
hjic-1161	230	67	catalyzed	catalyze	VERB
hjic-1161	230	68	1,4	1,4	NUM
hjic-1161	230	69	-	-	PUNCT
hjic-1161	230	70	addition	addition	NOUN
hjic-1161	230	71	(	(	PUNCT
hjic-1161	230	72	stetter	stetter	NOUN
hjic-1161	230	73	reaction	reaction	NOUN
hjic-1161	230	74	)	)	PUNCT
hjic-1161	230	75	of	of	ADP
hjic-1161	230	76	α	α	PROPN
hjic-1161	230	77	-	-	PUNCT
hjic-1161	230	78	ketoglutaric	ketoglutaric	NOUN
hjic-1161	230	79	acid	acid	NOUN
hjic-1161	230	80	to	to	ADP
hjic-1161	230	81	acrylonitrile	acrylonitrile	NOUN
hjic-1161	230	82	,	,	PUNCT
hjic-1161	230	83	j.	j.	PROPN
hjic-1161	230	84	biotechnol	biotechnol	PROPN
hjic-1161	230	85	.	.	PROPN
hjic-1161	230	86	,	,	PUNCT
hjic-1161	230	87	2018	2018	NUM
hjic-1161	230	88	,	,	PUNCT
hjic-1161	230	89	268	268	NUM
hjic-1161	230	90	,	,	PUNCT
hjic-1161	230	91	71–80	71–80	NUM
hjic-1161	230	92	doi	doi	NOUN
hjic-1161	230	93	:	:	PUNCT
hjic-1161	230	94	10.1016	10.1016	NUM
hjic-1161	230	95	/	/	SYM
hjic-1161	230	96	j.jbiotec.2018.01.013	j.jbiotec.2018.01.013	PROPN
hjic-1161	231	1	[	[	X
hjic-1161	231	2	28	28	NUM
hjic-1161	231	3	]	]	X
hjic-1161	231	4	börner	börner	NOUN
hjic-1161	231	5	,	,	PUNCT
hjic-1161	231	6	t.	t.	PROPN
hjic-1161	231	7	;	;	PUNCT
hjic-1161	231	8	rämisch	rämisch	PROPN
hjic-1161	231	9	,	,	PUNCT
hjic-1161	231	10	s.	s.	PROPN
hjic-1161	231	11	;	;	PUNCT
hjic-1161	231	12	reddem	reddem	PROPN
hjic-1161	231	13	,	,	PUNCT
hjic-1161	231	14	e.r	e.r	PROPN
hjic-1161	231	15	.	.	PROPN
hjic-1161	231	16	;	;	PUNCT
hjic-1161	231	17	bartsch	bartsch	PROPN
hjic-1161	231	18	,	,	PUNCT
hjic-1161	231	19	s.	s.	PROPN
hjic-1161	231	20	;	;	PUNCT
hjic-1161	231	21	vogel	vogel	PROPN
hjic-1161	231	22	,	,	PUNCT
hjic-1161	231	23	a.	a.	NOUN
hjic-1161	231	24	;	;	PUNCT
hjic-1161	231	25	thunnissen	thunnissen	PROPN
hjic-1161	231	26	,	,	PUNCT
hjic-1161	231	27	a.m.w.h	a.m.w.h	PROPN
hjic-1161	231	28	.	.	PROPN
hjic-1161	231	29	;	;	PUNCT
hjic-1161	231	30	adlercreutz	adlercreutz	ADJ
hjic-1161	231	31	,	,	PUNCT
hjic-1161	231	32	p.	p.	NOUN
hjic-1161	231	33	;	;	PUNCT
hjic-1161	231	34	grey	grey	PROPN
hjic-1161	231	35	,	,	PUNCT
hjic-1161	231	36	c.	c.	NOUN
hjic-1161	231	37	:	:	PUNCT
hjic-1161	231	38	explaining	explain	VERB
hjic-1161	231	39	operational	operational	ADJ
hjic-1161	231	40	instability	instability	NOUN
hjic-1161	231	41	hungarian	hungarian	ADJ
hjic-1161	231	42	journal	journal	NOUN
hjic-1161	231	43	of	of	ADP
hjic-1161	231	44	industry	industry	NOUN
hjic-1161	231	45	and	and	CCONJ
hjic-1161	231	46	chemistry	chemistry	NOUN
hjic-1161	231	47	https://doi.org/10.1007/s00253-016-7750-y	https://doi.org/10.1007/s00253-016-7750-y	PROPN
hjic-1161	231	48	https://doi.org/10.1007/s00253-016-7750-y	https://doi.org/10.1007/s00253-016-7750-y	PROPN
hjic-1161	231	49	https://doi.org/10.1021/tx300389z	https://doi.org/10.1021/tx300389z	PROPN
hjic-1161	231	50	https://doi.org/10.1021/tx300389z	https://doi.org/10.1021/tx300389z	PROPN
hjic-1161	231	51	https://www.cheric.org/pdf/jiec/ie13/ie13-1-0159.pdf	https://www.cheric.org/pdf/jiec/ie13/ie13-1-0159.pdf	PROPN
hjic-1161	231	52	https://doi.org/10.1016/j.bej.2013.02.005	https://doi.org/10.1016/j.bej.2013.02.005	VERB
hjic-1161	231	53	https://doi.org/10.1016/j.bej.2013.02.005	https://doi.org/10.1016/j.bej.2013.02.005	PROPN
hjic-1161	231	54	https://doi.org/10.1016/j.jbiosc.2016.02.003	https://doi.org/10.1016/j.jbiosc.2016.02.003	PROPN
hjic-1161	231	55	https://doi.org/10.1002/cctc.201500061	https://doi.org/10.1002/cctc.201500061	NOUN
hjic-1161	231	56	https://doi.org/10.1002/adsc.202000984	https://doi.org/10.1002/adsc.202000984	PROPN
hjic-1161	232	1	https://doi.org/10.1039/c5re00045a	https://doi.org/10.1039/c5re00045a	PROPN
hjic-1161	232	2	https://doi.org/10.1016/j.ces.2020.116312	https://doi.org/10.1016/j.ces.2020.116312	PROPN
hjic-1161	232	3	https://doi.org/10.1002/anie.202103805	https://doi.org/10.1002/anie.202103805	PROPN
hjic-1161	233	1	https://doi.org/10.1039/c7cs00906b	https://doi.org/10.1039/c7cs00906b	PROPN
hjic-1161	233	2	https://doi.org/10.1021/acscatal.7b00776	https://doi.org/10.1021/acscatal.7b00776	PROPN
hjic-1161	233	3	https://doi.org/10.1002/chem.201703353	https://doi.org/10.1002/chem.201703353	NOUN
hjic-1161	233	4	https://doi.org/10.1002/chem.201703353	https://doi.org/10.1002/chem.201703353	NOUN
hjic-1161	233	5	https://doi.org/10.1021/acs.oprd.0c00372	https://doi.org/10.1021/acs.oprd.0c00372	ADP
hjic-1161	233	6	http://silverstripe.fkit.hr/cabeq/past-issues/article/622	http://silverstripe.fkit.hr/cabeq/past-issues/article/622	PROPN
hjic-1161	233	7	https://doi.org/10.1039/c9re00453j	https://doi.org/10.1039/c9re00453j	PROPN
hjic-1161	233	8	https://doi.org/10.1002/adsc.201700360	https://doi.org/10.1002/adsc.201700360	DET
hjic-1161	233	9	https://doi.org/10.1002/adsc.201700360	https://doi.org/10.1002/adsc.201700360	PRON
hjic-1161	233	10	https://doi.org/10.1002/anie.201800343	https://doi.org/10.1002/anie.201800343	NOUN
hjic-1161	233	11	https://doi.org/10.1016/j.abb.2004.09.037	https://doi.org/10.1016/j.abb.2004.09.037	NOUN
hjic-1161	233	12	https://doi.org/10.1039/c5ra14414k	https://doi.org/10.1039/c5ra14414k	VERB
hjic-1161	233	13	https://doi.org/10.1039/c5ra14414k	https://doi.org/10.1039/c5ra14414k	PROPN
hjic-1161	233	14	https://doi.org/10.1016/j.nbt.2021.02.004	https://doi.org/10.1016/j.nbt.2021.02.004	PRON
hjic-1161	233	15	https://doi.org/10.1016/j.nbt.2021.02.004	https://doi.org/10.1016/j.nbt.2021.02.004	ADJ
hjic-1161	233	16	https://doi.org/10.1016/j.jbiotec.2018.01.013	https://doi.org/10.1016/j.jbiotec.2018.01.013	NOUN
hjic-1161	233	17	enzyme	enzyme	NOUN
hjic-1161	233	18	reaction	reaction	NOUN
hjic-1161	233	19	engineering	engineering	NOUN
hjic-1161	233	20	as	as	ADP
hjic-1161	233	21	a	a	DET
hjic-1161	233	22	tool	tool	NOUN
hjic-1161	233	23	55	55	NUM
hjic-1161	233	24	of	of	ADP
hjic-1161	233	25	amine	amine	ADJ
hjic-1161	233	26	transaminases	transaminase	NOUN
hjic-1161	233	27	:	:	PUNCT
hjic-1161	233	28	substrate	substrate	NOUN
hjic-1161	233	29	-	-	PUNCT
hjic-1161	233	30	induced	induce	VERB
hjic-1161	233	31	inactivation	inactivation	NOUN
hjic-1161	233	32	mechanism	mechanism	NOUN
hjic-1161	233	33	and	and	CCONJ
hjic-1161	233	34	influence	influence	NOUN
hjic-1161	233	35	of	of	ADP
hjic-1161	233	36	quaternary	quaternary	ADJ
hjic-1161	233	37	structure	structure	NOUN
hjic-1161	233	38	on	on	ADP
hjic-1161	233	39	enzyme	enzyme	NOUN
hjic-1161	233	40	–	–	PUNCT
hjic-1161	233	41	cofactor	cofactor	NOUN
hjic-1161	233	42	intermediate	intermediate	ADJ
hjic-1161	233	43	stability	stability	NOUN
hjic-1161	233	44	,	,	PUNCT
hjic-1161	233	45	acs	acs	PROPN
hjic-1161	233	46	catal	catal	PROPN
hjic-1161	233	47	.	.	PROPN
hjic-1161	233	48	,	,	PUNCT
hjic-1161	233	49	2017	2017	NUM
hjic-1161	233	50	,	,	PUNCT
hjic-1161	233	51	7(2	7(2	NUM
hjic-1161	233	52	)	)	PUNCT
hjic-1161	233	53	,	,	PUNCT
hjic-1161	233	54	1259–1269	1259–1269	NUM
hjic-1161	233	55	doi	doi	NOUN
hjic-1161	233	56	:	:	PUNCT
hjic-1161	233	57	10.1021	10.1021	NUM
hjic-1161	233	58	/	/	SYM
hjic-1161	233	59	acscatal.6b02100	acscatal.6b02100	PROPN
hjic-1161	234	1	[	[	X
hjic-1161	234	2	29	29	NUM
hjic-1161	234	3	]	]	X
hjic-1161	234	4	dias	dias	PROPN
hjic-1161	234	5	gomes	gome	NOUN
hjic-1161	234	6	,	,	PUNCT
hjic-1161	234	7	m.	m.	NOUN
hjic-1161	234	8	;	;	PUNCT
hjic-1161	234	9	woodley	woodley	NOUN
hjic-1161	234	10	,	,	PUNCT
hjic-1161	234	11	j.m	j.m	PROPN
hjic-1161	234	12	.	.	PROPN
hjic-1161	234	13	:	:	PUNCT
hjic-1161	234	14	considerations	consideration	NOUN
hjic-1161	234	15	when	when	SCONJ
hjic-1161	234	16	measuring	measure	VERB
hjic-1161	234	17	biocatalyst	biocatalyst	ADJ
hjic-1161	234	18	performance	performance	NOUN
hjic-1161	234	19	,	,	PUNCT
hjic-1161	234	20	molecules	molecule	NOUN
hjic-1161	234	21	,	,	PUNCT
hjic-1161	234	22	2019	2019	NUM
hjic-1161	234	23	,	,	PUNCT
hjic-1161	234	24	24(19	24(19	NUM
hjic-1161	234	25	)	)	PUNCT
hjic-1161	234	26	,	,	PUNCT
hjic-1161	234	27	3573	3573	NUM
hjic-1161	234	28	doi	doi	NOUN
hjic-1161	234	29	:	:	PUNCT
hjic-1161	234	30	10.3390	10.3390	NUM
hjic-1161	234	31	/	/	SYM
hjic-1161	234	32	molecules24193573	molecules24193573	PROPN
hjic-1161	234	33	[	[	X
hjic-1161	234	34	30	30	NUM
hjic-1161	234	35	]	]	SYM
hjic-1161	234	36	česnik	česnik	X
hjic-1161	234	37	,	,	PUNCT
hjic-1161	234	38	m.	m.	NOUN
hjic-1161	234	39	;	;	PUNCT
hjic-1161	234	40	sudar	sudar	NOUN
hjic-1161	234	41	,	,	PUNCT
hjic-1161	234	42	m.	m.	NOUN
hjic-1161	234	43	;	;	PUNCT
hjic-1161	234	44	roldan	roldan	PROPN
hjic-1161	234	45	,	,	PUNCT
hjic-1161	234	46	r.	r.	PROPN
hjic-1161	234	47	;	;	PUNCT
hjic-1161	234	48	hernandez	hernandez	PROPN
hjic-1161	234	49	,	,	PUNCT
hjic-1161	234	50	k.	k.	PROPN
hjic-1161	234	51	;	;	PUNCT
hjic-1161	234	52	parella	parella	NOUN
hjic-1161	234	53	,	,	PUNCT
hjic-1161	234	54	t.	t.	PROPN
hjic-1161	234	55	;	;	PUNCT
hjic-1161	234	56	clapés	clapé	NOUN
hjic-1161	234	57	,	,	PUNCT
hjic-1161	234	58	p.	p.	NOUN
hjic-1161	234	59	;	;	PUNCT
hjic-1161	234	60	charnock	charnock	PROPN
hjic-1161	234	61	,	,	PUNCT
hjic-1161	234	62	s.	s.	PROPN
hjic-1161	234	63	;	;	PUNCT
hjic-1161	234	64	vasić-rački	vasić-rački	NOUN
hjic-1161	234	65	,	,	PUNCT
hjic-1161	234	66	ð	ð	PROPN
hjic-1161	234	67	.	.	PUNCT
hjic-1161	234	68	;	;	PUNCT
hjic-1161	234	69	findrik	findrik	VERB
hjic-1161	234	70	blažević	blažević	PROPN
hjic-1161	234	71	,	,	PUNCT
hjic-1161	234	72	z.	z.	PROPN
hjic-1161	234	73	:	:	PUNCT
hjic-1161	234	74	modelbased	modelbase	VERB
hjic-1161	234	75	optimization	optimization	NOUN
hjic-1161	234	76	of	of	ADP
hjic-1161	234	77	the	the	DET
hjic-1161	234	78	enzymatic	enzymatic	ADJ
hjic-1161	234	79	aldol	aldol	NOUN
hjic-1161	234	80	addition	addition	NOUN
hjic-1161	234	81	of	of	ADP
hjic-1161	234	82	propanal	propanal	NOUN
hjic-1161	234	83	to	to	PART
hjic-1161	234	84	formaldehyde	formaldehyde	VERB
hjic-1161	234	85	:	:	PUNCT
hjic-1161	234	86	a	a	DET
hjic-1161	234	87	first	first	ADJ
hjic-1161	234	88	step	step	NOUN
hjic-1161	234	89	towards	towards	ADP
hjic-1161	234	90	enzymatic	enzymatic	ADJ
hjic-1161	234	91	synthesis	synthesis	NOUN
hjic-1161	234	92	of	of	ADP
hjic-1161	234	93	3	3	NUM
hjic-1161	234	94	-	-	PUNCT
hjic-1161	234	95	hydroxybutyric	hydroxybutyric	ADJ
hjic-1161	234	96	acid	acid	NOUN
hjic-1161	234	97	,	,	PUNCT
hjic-1161	234	98	chem	chem	NOUN
hjic-1161	234	99	.	.	PUNCT
hjic-1161	235	1	eng	eng	PROPN
hjic-1161	235	2	.	.	PUNCT
hjic-1161	236	1	res	res	PROPN
hjic-1161	236	2	.	.	PUNCT
hjic-1161	237	1	des	des	PROPN
hjic-1161	237	2	.	.	PROPN
hjic-1161	237	3	,	,	PUNCT
hjic-1161	237	4	2019	2019	NUM
hjic-1161	237	5	,	,	PUNCT
hjic-1161	237	6	150	150	NUM
hjic-1161	237	7	,	,	PUNCT
hjic-1161	237	8	140–152	140–152	NUM
hjic-1161	237	9	doi	doi	NOUN
hjic-1161	237	10	:	:	PUNCT
hjic-1161	237	11	10.1016	10.1016	NUM
hjic-1161	237	12	/	/	SYM
hjic-1161	237	13	j.cherd.2019.06.025	j.cherd.2019.06.025	PROPN
hjic-1161	238	1	[	[	X
hjic-1161	238	2	31	31	NUM
hjic-1161	238	3	]	]	PUNCT
hjic-1161	238	4	scherkus	scherkus	NOUN
hjic-1161	238	5	,	,	PUNCT
hjic-1161	238	6	c.	c.	PROPN
hjic-1161	238	7	;	;	PUNCT
hjic-1161	238	8	schmidt	schmidt	PROPN
hjic-1161	238	9	,	,	PUNCT
hjic-1161	238	10	s.	s.	PROPN
hjic-1161	238	11	;	;	PUNCT
hjic-1161	238	12	bornscheuer	bornscheuer	PROPN
hjic-1161	238	13	,	,	PUNCT
hjic-1161	238	14	u.t	u.t	PROPN
hjic-1161	238	15	.	.	PROPN
hjic-1161	238	16	;	;	PUNCT
hjic-1161	238	17	gröger	gröger	PROPN
hjic-1161	238	18	,	,	PUNCT
hjic-1161	238	19	h.	h.	PROPN
hjic-1161	238	20	;	;	PUNCT
hjic-1161	238	21	kara	kara	PROPN
hjic-1161	238	22	,	,	PUNCT
hjic-1161	238	23	s.	s.	PROPN
hjic-1161	238	24	;	;	PUNCT
hjic-1161	238	25	liese	liese	PROPN
hjic-1161	238	26	,	,	PUNCT
hjic-1161	238	27	a.	a.	NOUN
hjic-1161	238	28	:	:	PUNCT
hjic-1161	238	29	a	a	DET
hjic-1161	238	30	fed	feed	VERB
hjic-1161	238	31	-	-	PUNCT
hjic-1161	238	32	batch	batch	NOUN
hjic-1161	238	33	synthetic	synthetic	ADJ
hjic-1161	238	34	strategy	strategy	NOUN
hjic-1161	238	35	for	for	ADP
hjic-1161	238	36	a	a	DET
hjic-1161	238	37	three	three	NUM
hjic-1161	238	38	-	-	PUNCT
hjic-1161	238	39	step	step	NOUN
hjic-1161	238	40	enzymatic	enzymatic	ADJ
hjic-1161	238	41	synthesis	synthesis	NOUN
hjic-1161	238	42	of	of	ADP
hjic-1161	238	43	poly	poly	ADJ
hjic-1161	238	44	-	-	PUNCT
hjic-1161	238	45	ε	ε	NOUN
hjic-1161	238	46	-	-	PUNCT
hjic-1161	238	47	caprolactone	caprolactone	NOUN
hjic-1161	238	48	,	,	PUNCT
hjic-1161	238	49	chemcatchem	chemcatchem	NOUN
hjic-1161	238	50	,	,	PUNCT
hjic-1161	238	51	2016	2016	NUM
hjic-1161	238	52	,	,	PUNCT
hjic-1161	238	53	8(22	8(22	NUM
hjic-1161	238	54	)	)	PUNCT
hjic-1161	238	55	,	,	PUNCT
hjic-1161	238	56	3446–3452	3446–3452	NUM
hjic-1161	238	57	doi	doi	NOUN
hjic-1161	238	58	:	:	PUNCT
hjic-1161	238	59	10.1002	10.1002	NUM
hjic-1161	238	60	/	/	SYM
hjic-1161	238	61	cctc.201600806	cctc.201600806	NOUN
hjic-1161	239	1	[	[	X
hjic-1161	239	2	32	32	NUM
hjic-1161	239	3	]	]	PUNCT
hjic-1161	239	4	andrić	andrić	ADV
hjic-1161	239	5	,	,	PUNCT
hjic-1161	239	6	p.	p.	PROPN
hjic-1161	239	7	;	;	PUNCT
hjic-1161	239	8	meyer	meyer	PROPN
hjic-1161	239	9	,	,	PUNCT
hjic-1161	239	10	a.s	a.s	PROPN
hjic-1161	239	11	.	.	PROPN
hjic-1161	239	12	;	;	PUNCT
hjic-1161	239	13	jensen	jensen	PROPN
hjic-1161	239	14	,	,	PUNCT
hjic-1161	239	15	p.a	p.a	PROPN
hjic-1161	239	16	.	.	PROPN
hjic-1161	239	17	;	;	PUNCT
hjic-1161	239	18	damjohansen	damjohansen	PROPN
hjic-1161	239	19	,	,	PUNCT
hjic-1161	239	20	k.	k.	NOUN
hjic-1161	239	21	:	:	PUNCT
hjic-1161	239	22	reactor	reactor	NOUN
hjic-1161	239	23	design	design	NOUN
hjic-1161	239	24	for	for	ADP
hjic-1161	239	25	minimizing	minimize	VERB
hjic-1161	239	26	product	product	NOUN
hjic-1161	239	27	inhibition	inhibition	NOUN
hjic-1161	239	28	during	during	ADP
hjic-1161	239	29	enzymatic	enzymatic	ADJ
hjic-1161	239	30	lignocellulose	lignocellulose	ADJ
hjic-1161	239	31	hydrolysis	hydrolysis	NOUN
hjic-1161	239	32	:	:	PUNCT
hjic-1161	239	33	ii	ii	X
hjic-1161	239	34	.	.	PUNCT
hjic-1161	240	1	quantification	quantification	NOUN
hjic-1161	240	2	of	of	ADP
hjic-1161	240	3	inhibition	inhibition	NOUN
hjic-1161	240	4	and	and	CCONJ
hjic-1161	240	5	suitability	suitability	NOUN
hjic-1161	240	6	of	of	ADP
hjic-1161	240	7	membrane	membrane	NOUN
hjic-1161	240	8	reactors	reactor	NOUN
hjic-1161	240	9	,	,	PUNCT
hjic-1161	240	10	biotechnol	biotechnol	NOUN
hjic-1161	240	11	.	.	PUNCT
hjic-1161	241	1	adv	adv	PROPN
hjic-1161	241	2	.	.	PROPN
hjic-1161	241	3	,	,	PUNCT
hjic-1161	241	4	2010	2010	NUM
hjic-1161	241	5	,	,	PUNCT
hjic-1161	241	6	28(3	28(3	NUM
hjic-1161	241	7	)	)	PUNCT
hjic-1161	241	8	,	,	PUNCT
hjic-1161	241	9	407–425	407–425	NUM
hjic-1161	241	10	doi	doi	NOUN
hjic-1161	241	11	:	:	PUNCT
hjic-1161	241	12	10.1016	10.1016	NUM
hjic-1161	241	13	/	/	SYM
hjic-1161	241	14	j.biotechadv.2010.02.005	j.biotechadv.2010.02.005	PROPN
hjic-1161	242	1	[	[	X
hjic-1161	242	2	33	33	NUM
hjic-1161	242	3	]	]	X
hjic-1161	242	4	lindeque	lindeque	NOUN
hjic-1161	242	5	,	,	PUNCT
hjic-1161	242	6	r.m	r.m	PROPN
hjic-1161	242	7	.	.	PROPN
hjic-1161	242	8	;	;	PUNCT
hjic-1161	242	9	woodley	woodley	NOUN
hjic-1161	242	10	,	,	PUNCT
hjic-1161	242	11	j.m	j.m	PROPN
hjic-1161	242	12	.	.	PROPN
hjic-1161	242	13	:	:	PUNCT
hjic-1161	242	14	reactor	reactor	NOUN
hjic-1161	242	15	selection	selection	NOUN
hjic-1161	242	16	for	for	ADP
hjic-1161	242	17	effective	effective	ADJ
hjic-1161	242	18	continuous	continuous	ADJ
hjic-1161	242	19	biocatalytic	biocatalytic	ADJ
hjic-1161	242	20	production	production	NOUN
hjic-1161	242	21	of	of	ADP
hjic-1161	242	22	pharmaceuticals	pharmaceutical	NOUN
hjic-1161	242	23	,	,	PUNCT
hjic-1161	242	24	catalysts	catalyst	NOUN
hjic-1161	242	25	,	,	PUNCT
hjic-1161	242	26	2019	2019	NUM
hjic-1161	242	27	,	,	PUNCT
hjic-1161	242	28	9(3	9(3	NUM
hjic-1161	242	29	)	)	PUNCT
hjic-1161	242	30	,	,	PUNCT
hjic-1161	242	31	262	262	NUM
hjic-1161	242	32	doi	doi	NOUN
hjic-1161	242	33	:	:	PUNCT
hjic-1161	242	34	10.3390	10.3390	NUM
hjic-1161	242	35	/	/	SYM
hjic-1161	242	36	catal9030262	catal9030262	NOUN
hjic-1161	242	37	[	[	X
hjic-1161	242	38	34	34	NUM
hjic-1161	242	39	]	]	X
hjic-1161	242	40	cho	cho	PROPN
hjic-1161	242	41	,	,	PUNCT
hjic-1161	242	42	y.s	y.s	PROPN
hjic-1161	242	43	.	.	PROPN
hjic-1161	242	44	;	;	PUNCT
hjic-1161	242	45	lim	lim	PROPN
hjic-1161	242	46	,	,	PUNCT
hjic-1161	242	47	h.s	h.s	PROPN
hjic-1161	242	48	.	.	PROPN
hjic-1161	242	49	:	:	PUNCT
hjic-1161	243	1	comparison	comparison	NOUN
hjic-1161	243	2	of	of	ADP
hjic-1161	243	3	various	various	ADJ
hjic-1161	243	4	estimation	estimation	NOUN
hjic-1161	243	5	methods	method	NOUN
hjic-1161	243	6	for	for	ADP
hjic-1161	243	7	the	the	DET
hjic-1161	243	8	parameters	parameter	NOUN
hjic-1161	243	9	of	of	ADP
hjic-1161	243	10	michaelismenten	michaelismenten	VERB
hjic-1161	243	11	equation	equation	NOUN
hjic-1161	243	12	based	base	VERB
hjic-1161	243	13	on	on	ADP
hjic-1161	243	14	in	in	ADP
hjic-1161	243	15	vitro	vitro	X
hjic-1161	243	16	elimination	elimination	NOUN
hjic-1161	243	17	kinetic	kinetic	NOUN
hjic-1161	243	18	simulation	simulation	NOUN
hjic-1161	243	19	data	data	PROPN
hjic-1161	243	20	,	,	PUNCT
hjic-1161	243	21	transl	transl	PROPN
hjic-1161	243	22	.	.	PUNCT
hjic-1161	244	1	clin	clin	PROPN
hjic-1161	244	2	.	.	PUNCT
hjic-1161	245	1	pharmacol	pharmacol	PROPN
hjic-1161	245	2	.	.	PROPN
hjic-1161	245	3	,	,	PUNCT
hjic-1161	245	4	2018	2018	NUM
hjic-1161	245	5	,	,	PUNCT
hjic-1161	245	6	26(1	26(1	NUM
hjic-1161	245	7	)	)	PUNCT
hjic-1161	245	8	,	,	PUNCT
hjic-1161	245	9	39–47	39–47	NUM
hjic-1161	245	10	doi	doi	NOUN
hjic-1161	245	11	:	:	PUNCT
hjic-1161	245	12	10.12793	10.12793	NUM
hjic-1161	245	13	/	/	SYM
hjic-1161	245	14	tcp.2018.26.1.39	tcp.2018.26.1.39	NOUN
hjic-1161	245	15	[	[	X
hjic-1161	245	16	35	35	NUM
hjic-1161	245	17	]	]	X
hjic-1161	245	18	srinivasan	srinivasan	NOUN
hjic-1161	245	19	,	,	PUNCT
hjic-1161	245	20	b.	b.	PROPN
hjic-1161	245	21	:	:	PUNCT
hjic-1161	245	22	a	a	DET
hjic-1161	245	23	guide	guide	NOUN
hjic-1161	245	24	to	to	ADP
hjic-1161	245	25	the	the	DET
hjic-1161	245	26	michaelis	michaelis	PROPN
hjic-1161	245	27	–	–	PUNCT
hjic-1161	245	28	menten	menten	ADJ
hjic-1161	245	29	equation	equation	NOUN
hjic-1161	245	30	:	:	PUNCT
hjic-1161	245	31	steady	steady	ADJ
hjic-1161	245	32	state	state	NOUN
hjic-1161	245	33	and	and	CCONJ
hjic-1161	245	34	beyond	beyond	ADV
hjic-1161	245	35	,	,	PUNCT
hjic-1161	245	36	febs	febs	NOUN
hjic-1161	245	37	j.	j.	PROPN
hjic-1161	245	38	,	,	PUNCT
hjic-1161	245	39	2021	2021	NUM
hjic-1161	245	40	doi	doi	NOUN
hjic-1161	245	41	:	:	PUNCT
hjic-1161	245	42	10.1111	10.1111	NUM
hjic-1161	245	43	/	/	SYM
hjic-1161	246	1	febs.16124	febs.16124	PROPN
hjic-1161	247	1	[	[	X
hjic-1161	247	2	36	36	NUM
hjic-1161	247	3	]	]	X
hjic-1161	247	4	bommarius	bommarius	PROPN
hjic-1161	247	5	,	,	PUNCT
hjic-1161	247	6	a.s	a.s	PROPN
hjic-1161	247	7	.	.	PROPN
hjic-1161	247	8	;	;	PUNCT
hjic-1161	247	9	riebel	riebel	PROPN
hjic-1161	247	10	,	,	PUNCT
hjic-1161	247	11	b.r	b.r	PROPN
hjic-1161	247	12	.	.	PROPN
hjic-1161	247	13	:	:	PUNCT
hjic-1161	247	14	biocatalysis	biocatalysis	NOUN
hjic-1161	247	15	:	:	PUNCT
hjic-1161	247	16	fundamentals	fundamental	NOUN
hjic-1161	247	17	and	and	CCONJ
hjic-1161	247	18	applications	application	NOUN
hjic-1161	247	19	(	(	PUNCT
hjic-1161	247	20	wiley	wiley	PROPN
hjic-1161	247	21	,	,	PUNCT
hjic-1161	247	22	new	new	PROPN
hjic-1161	247	23	york	york	PROPN
hjic-1161	247	24	,	,	PUNCT
hjic-1161	247	25	usa	usa	PROPN
hjic-1161	247	26	)	)	PUNCT
hjic-1161	247	27	,	,	PUNCT
hjic-1161	247	28	1st	1st	PROPN
hjic-1161	247	29	edition	edition	NOUN
hjic-1161	247	30	,	,	PUNCT
hjic-1161	247	31	2004	2004	NUM
hjic-1161	247	32	isbn	isbn	NOUN
hjic-1161	247	33	:	:	PUNCT
hjic-1161	247	34	978	978	NUM
hjic-1161	247	35	-	-	SYM
hjic-1161	247	36	3	3	NUM
hjic-1161	247	37	-	-	PUNCT
hjic-1161	247	38	527	527	NUM
hjic-1161	247	39	-	-	PUNCT
hjic-1161	247	40	30344	30344	NUM
hjic-1161	247	41	-	-	SYM
hjic-1161	247	42	1	1	NUM
hjic-1161	248	1	[	[	SYM
hjic-1161	248	2	37	37	NUM
hjic-1161	248	3	]	]	PUNCT
hjic-1161	248	4	lejeune	lejeune	PROPN
hjic-1161	248	5	,	,	PUNCT
hjic-1161	248	6	a.	a.	NOUN
hjic-1161	248	7	;	;	PUNCT
hjic-1161	248	8	vanhove	vanhove	NOUN
hjic-1161	248	9	,	,	PUNCT
hjic-1161	248	10	m.	m.	NOUN
hjic-1161	248	11	;	;	PUNCT
hjic-1161	248	12	lamotte	lamotte	NOUN
hjic-1161	248	13	-	-	PUNCT
hjic-1161	248	14	brasseur	brasseur	PROPN
hjic-1161	248	15	,	,	PUNCT
hjic-1161	248	16	j.	j.	PROPN
hjic-1161	248	17	;	;	PUNCT
hjic-1161	248	18	pain	pain	NOUN
hjic-1161	248	19	,	,	PUNCT
hjic-1161	248	20	r.h	r.h	PROPN
hjic-1161	248	21	.	.	PROPN
hjic-1161	248	22	;	;	PUNCT
hjic-1161	248	23	frčre	frčre	ADJ
hjic-1161	248	24	,	,	PUNCT
hjic-1161	248	25	j.m	j.m	PROPN
hjic-1161	248	26	.	.	PROPN
hjic-1161	248	27	;	;	PUNCT
hjic-1161	248	28	matagne	matagne	NOUN
hjic-1161	248	29	,	,	PUNCT
hjic-1161	248	30	a.	a.	NOUN
hjic-1161	248	31	:	:	PUNCT
hjic-1161	248	32	quantitative	quantitative	ADJ
hjic-1161	248	33	analysis	analysis	NOUN
hjic-1161	248	34	of	of	ADP
hjic-1161	248	35	the	the	DET
hjic-1161	248	36	stabilization	stabilization	NOUN
hjic-1161	248	37	by	by	ADP
hjic-1161	248	38	substrate	substrate	NOUN
hjic-1161	248	39	of	of	ADP
hjic-1161	248	40	staphylococcus	staphylococcus	NOUN
hjic-1161	248	41	aureus	aureus	PROPN
hjic-1161	248	42	pc1	pc1	PROPN
hjic-1161	248	43	β	β	X
hjic-1161	248	44	-	-	PUNCT
hjic-1161	248	45	lactamase	lactamase	ADJ
hjic-1161	248	46	,	,	PUNCT
hjic-1161	248	47	chem	chem	NOUN
hjic-1161	248	48	.	.	PUNCT
hjic-1161	249	1	biol	biol	PROPN
hjic-1161	249	2	.	.	PUNCT
hjic-1161	249	3	,	,	PUNCT
hjic-1161	249	4	2001	2001	NUM
hjic-1161	249	5	,	,	PUNCT
hjic-1161	249	6	8(8	8(8	NUM
hjic-1161	249	7	)	)	PUNCT
hjic-1161	249	8	,	,	PUNCT
hjic-1161	249	9	831–842	831–842	NUM
hjic-1161	249	10	doi	doi	NOUN
hjic-1161	249	11	:	:	PUNCT
hjic-1161	249	12	10.1016	10.1016	NUM
hjic-1161	249	13	/	/	SYM
hjic-1161	249	14	s1074	s1074	PROPN
hjic-1161	249	15	-	-	PUNCT
hjic-1161	249	16	5521(01)000539	5521(01)000539	PROPN
hjic-1161	250	1	[	[	X
hjic-1161	250	2	38	38	NUM
hjic-1161	250	3	]	]	SYM
hjic-1161	250	4	vasič-rački	vasič-rački	NOUN
hjic-1161	250	5	,	,	PUNCT
hjic-1161	250	6	ð	ð	PROPN
hjic-1161	250	7	.	.	PUNCT
hjic-1161	250	8	;	;	PUNCT
hjic-1161	250	9	bongs	bong	NOUN
hjic-1161	250	10	,	,	PUNCT
hjic-1161	250	11	j.	j.	PROPN
hjic-1161	250	12	;	;	PUNCT
hjic-1161	250	13	schörken	schörken	PROPN
hjic-1161	250	14	,	,	PUNCT
hjic-1161	250	15	u.	u.	PROPN
hjic-1161	250	16	;	;	PUNCT
hjic-1161	250	17	sprenger	sprenger	NOUN
hjic-1161	250	18	,	,	PUNCT
hjic-1161	250	19	g.	g.	PROPN
hjic-1161	250	20	;	;	PUNCT
hjic-1161	250	21	liese	liese	PROPN
hjic-1161	250	22	,	,	PUNCT
hjic-1161	250	23	a.	a.	NOUN
hjic-1161	250	24	:	:	PUNCT
hjic-1161	250	25	modeling	modeling	NOUN
hjic-1161	250	26	of	of	ADP
hjic-1161	250	27	reaction	reaction	NOUN
hjic-1161	250	28	kinetics	kinetic	NOUN
hjic-1161	250	29	for	for	ADP
hjic-1161	250	30	reactor	reactor	NOUN
hjic-1161	250	31	selection	selection	NOUN
hjic-1161	250	32	in	in	ADP
hjic-1161	250	33	the	the	DET
hjic-1161	250	34	case	case	NOUN
hjic-1161	250	35	of	of	ADP
hjic-1161	250	36	l	l	ADJ
hjic-1161	250	37	-	-	PUNCT
hjic-1161	250	38	erythrulose	erythrulose	ADJ
hjic-1161	250	39	synthesis	synthesis	NOUN
hjic-1161	250	40	,	,	PUNCT
hjic-1161	250	41	bioprocess	bioprocess	NOUN
hjic-1161	250	42	biosyst	biosyst	NOUN
hjic-1161	250	43	.	.	PUNCT
hjic-1161	251	1	eng	eng	PROPN
hjic-1161	251	2	.	.	PROPN
hjic-1161	251	3	,	,	PUNCT
hjic-1161	251	4	2003	2003	NUM
hjic-1161	251	5	,	,	PUNCT
hjic-1161	251	6	25	25	NUM
hjic-1161	251	7	,	,	PUNCT
hjic-1161	251	8	285–290	285–290	NUM
hjic-1161	251	9	doi	doi	NOUN
hjic-1161	251	10	:	:	PUNCT
hjic-1161	251	11	10.1007	10.1007	NUM
hjic-1161	251	12	/	/	SYM
hjic-1161	251	13	s00449	s00449	NOUN
hjic-1161	251	14	-	-	PUNCT
hjic-1161	251	15	002	002	NUM
hjic-1161	251	16	-	-	PUNCT
hjic-1161	251	17	0312	0312	NUM
hjic-1161	251	18	-	-	PUNCT
hjic-1161	251	19	y	y	NOUN
hjic-1161	251	20	[	[	X
hjic-1161	251	21	39	39	NUM
hjic-1161	251	22	]	]	PUNCT
hjic-1161	251	23	findrik	findrik	NOUN
hjic-1161	251	24	,	,	PUNCT
hjic-1161	251	25	z.	z.	PROPN
hjic-1161	251	26	;	;	PUNCT
hjic-1161	251	27	valentović	valentović	ADJ
hjic-1161	251	28	,	,	PUNCT
hjic-1161	251	29	i.	i.	NOUN
hjic-1161	251	30	;	;	PUNCT
hjic-1161	251	31	vasić-rački	vasić-rački	NOUN
hjic-1161	251	32	,	,	PUNCT
hjic-1161	251	33	ð	ð	PROPN
hjic-1161	251	34	.	.	PUNCT
hjic-1161	251	35	:	:	PUNCT
hjic-1161	252	1	a	a	DET
hjic-1161	252	2	mathematical	mathematical	ADJ
hjic-1161	252	3	model	model	NOUN
hjic-1161	252	4	of	of	ADP
hjic-1161	252	5	oxidative	oxidative	ADJ
hjic-1161	252	6	deamination	deamination	NOUN
hjic-1161	252	7	of	of	ADP
hjic-1161	252	8	amino	amino	NOUN
hjic-1161	252	9	acid	acid	NOUN
hjic-1161	252	10	catalyzed	catalyze	VERB
hjic-1161	252	11	by	by	ADP
hjic-1161	252	12	two	two	NUM
hjic-1161	252	13	d	d	ADJ
hjic-1161	252	14	-	-	ADJ
hjic-1161	252	15	amino	amino	ADJ
hjic-1161	252	16	acid	acid	NOUN
hjic-1161	252	17	oxidases	oxidase	NOUN
hjic-1161	252	18	and	and	CCONJ
hjic-1161	252	19	influence	influence	NOUN
hjic-1161	252	20	of	of	ADP
hjic-1161	252	21	aeration	aeration	NOUN
hjic-1161	252	22	on	on	ADP
hjic-1161	252	23	enzyme	enzyme	NOUN
hjic-1161	252	24	stability	stability	NOUN
hjic-1161	252	25	,	,	PUNCT
hjic-1161	252	26	appl	appl	PROPN
hjic-1161	252	27	.	.	PROPN
hjic-1161	252	28	biochem	biochem	PROPN
hjic-1161	252	29	.	.	PUNCT
hjic-1161	253	1	biotechnol	biotechnol	PROPN
hjic-1161	253	2	.	.	PUNCT
hjic-1161	253	3	,	,	PUNCT
hjic-1161	253	4	2014	2014	NUM
hjic-1161	253	5	,	,	PUNCT
hjic-1161	253	6	172(6	172(6	NUM
hjic-1161	253	7	)	)	PUNCT
hjic-1161	253	8	,	,	PUNCT
hjic-1161	253	9	3092–3105	3092–3105	NUM
hjic-1161	253	10	doi	doi	NOUN
hjic-1161	253	11	:	:	PUNCT
hjic-1161	253	12	10.1007	10.1007	NUM
hjic-1161	253	13	/	/	SYM
hjic-1161	253	14	s12010	s12010	NOUN
hjic-1161	253	15	-	-	PUNCT
hjic-1161	253	16	014	014	NUM
hjic-1161	253	17	-	-	PUNCT
hjic-1161	253	18	0735	0735	NUM
hjic-1161	253	19	-	-	SYM
hjic-1161	253	20	3	3	NUM
hjic-1161	253	21	[	[	X
hjic-1161	253	22	40	40	NUM
hjic-1161	253	23	]	]	X
hjic-1161	253	24	lindeque	lindeque	NOUN
hjic-1161	253	25	,	,	PUNCT
hjic-1161	253	26	r.m	r.m	PROPN
hjic-1161	253	27	.	.	PROPN
hjic-1161	253	28	;	;	PUNCT
hjic-1161	253	29	woodley	woodley	NOUN
hjic-1161	253	30	,	,	PUNCT
hjic-1161	253	31	j.m	j.m	PROPN
hjic-1161	253	32	.	.	PROPN
hjic-1161	253	33	:	:	PUNCT
hjic-1161	254	1	the	the	DET
hjic-1161	254	2	effect	effect	NOUN
hjic-1161	254	3	of	of	ADP
hjic-1161	254	4	dissolved	dissolved	ADJ
hjic-1161	254	5	oxygen	oxygen	NOUN
hjic-1161	254	6	on	on	ADP
hjic-1161	254	7	kinetics	kinetic	NOUN
hjic-1161	254	8	during	during	ADP
hjic-1161	254	9	continuous	continuous	ADJ
hjic-1161	254	10	biocatalytic	biocatalytic	ADJ
hjic-1161	254	11	oxidations	oxidation	NOUN
hjic-1161	254	12	,	,	PUNCT
hjic-1161	254	13	org	org	NOUN
hjic-1161	254	14	.	.	PUNCT
hjic-1161	254	15	process	process	NOUN
hjic-1161	254	16	res	re	NOUN
hjic-1161	254	17	.	.	PUNCT
hjic-1161	255	1	dev	dev	PROPN
hjic-1161	255	2	.	.	PROPN
hjic-1161	255	3	,	,	PUNCT
hjic-1161	255	4	2020	2020	NUM
hjic-1161	255	5	,	,	PUNCT
hjic-1161	255	6	24(10	24(10	NUM
hjic-1161	255	7	)	)	PUNCT
hjic-1161	255	8	,	,	PUNCT
hjic-1161	255	9	2055–2063	2055–2063	NUM
hjic-1161	255	10	doi	doi	NOUN
hjic-1161	255	11	:	:	PUNCT
hjic-1161	255	12	10.1021	10.1021	NUM
hjic-1161	255	13	/	/	SYM
hjic-1161	255	14	acs.oprd.0c00140	acs.oprd.0c00140	ADJ
hjic-1161	255	15	[	[	X
hjic-1161	255	16	41	41	NUM
hjic-1161	255	17	]	]	X
hjic-1161	255	18	mcdonald	mcdonald	PROPN
hjic-1161	255	19	,	,	PUNCT
hjic-1161	255	20	a.g	a.g	PROPN
hjic-1161	255	21	.	.	PROPN
hjic-1161	255	22	;	;	PUNCT
hjic-1161	255	23	tipton	tipton	PROPN
hjic-1161	255	24	,	,	PUNCT
hjic-1161	255	25	k.f	k.f	PROPN
hjic-1161	255	26	.	.	PROPN
hjic-1161	255	27	:	:	PUNCT
hjic-1161	255	28	parameter	parameter	NOUN
hjic-1161	255	29	reliability	reliability	NOUN
hjic-1161	255	30	and	and	CCONJ
hjic-1161	255	31	understanding	understand	VERB
hjic-1161	255	32	enzyme	enzyme	NOUN
hjic-1161	255	33	function	function	NOUN
hjic-1161	255	34	,	,	PUNCT
hjic-1161	255	35	molecules	molecule	NOUN
hjic-1161	255	36	,	,	PUNCT
hjic-1161	255	37	2022	2022	NUM
hjic-1161	255	38	,	,	PUNCT
hjic-1161	255	39	27(1	27(1	NUM
hjic-1161	255	40	)	)	PUNCT
hjic-1161	255	41	,	,	PUNCT
hjic-1161	255	42	263	263	NUM
hjic-1161	255	43	doi	doi	NOUN
hjic-1161	255	44	:	:	PUNCT
hjic-1161	255	45	10.3390	10.3390	NUM
hjic-1161	255	46	/	/	SYM
hjic-1161	255	47	molecules27010263	molecules27010263	PROPN
hjic-1161	255	48	50	50	NUM
hjic-1161	255	49	pp	pp	NOUN
hjic-1161	255	50	.	.	PUNCT
hjic-1161	256	1	45–55	45–55	NUM
hjic-1161	256	2	(	(	PUNCT
hjic-1161	256	3	2022	2022	NUM
hjic-1161	256	4	)	)	PUNCT
hjic-1161	256	5	https://doi.org/10.1021/acscatal.6b02100	https://doi.org/10.1021/acscatal.6b02100	PROPN
hjic-1161	256	6	https://doi.org/10.1021/acscatal.6b02100	https://doi.org/10.1021/acscatal.6b02100	PROPN
hjic-1161	256	7	https://doi.org/10.3390/molecules24193573	https://doi.org/10.3390/molecules24193573	NOUN
hjic-1161	256	8	https://doi.org/10.3390/molecules24193573	https://doi.org/10.3390/molecules24193573	NOUN
hjic-1161	256	9	https://doi.org/10.1016/j.cherd.2019.06.025	https://doi.org/10.1016/j.cherd.2019.06.025	NOUN
hjic-1161	256	10	https://doi.org/10.1002/cctc.201600806	https://doi.org/10.1002/cctc.201600806	VERB
hjic-1161	256	11	https://doi.org/10.1016/j.biotechadv.2010.02.005	https://doi.org/10.1016/j.biotechadv.2010.02.005	PROPN
hjic-1161	256	12	https://doi.org/10.1016/j.biotechadv.2010.02.005	https://doi.org/10.1016/j.biotechadv.2010.02.005	NUM
hjic-1161	256	13	https://doi.org/10.3390/catal9030262	https://doi.org/10.3390/catal9030262	PROPN
hjic-1161	256	14	https://doi.org/10.3390/catal9030262	https://doi.org/10.3390/catal9030262	PROPN
hjic-1161	256	15	https://doi.org/10.12793/tcp.2018.26.1.39	https://doi.org/10.12793/tcp.2018.26.1.39	X
hjic-1161	256	16	https://doi.org/10.1111/febs.16124	https://doi.org/10.1111/febs.16124	NOUN
hjic-1161	256	17	https://doi.org/10.1016/s1074-5521(01)00053-9	https://doi.org/10.1016/s1074-5521(01)00053-9	PROPN
hjic-1161	256	18	https://doi.org/10.1016/s1074-5521(01)00053-9	https://doi.org/10.1016/s1074-5521(01)00053-9	ADJ
hjic-1161	256	19	https://doi.org/10.1007/s00449-002-0312-y	https://doi.org/10.1007/s00449-002-0312-y	NOUN
hjic-1161	256	20	https://doi.org/10.1007/s12010-014-0735-3	https://doi.org/10.1007/s12010-014-0735-3	PROPN
hjic-1161	256	21	https://doi.org/10.1021/acs.oprd.0c00140	https://doi.org/10.1021/acs.oprd.0c00140	ADV
hjic-1161	256	22	https://doi.org/10.3390/molecules27010263	https://doi.org/10.3390/molecules27010263	NOUN
hjic-1161	256	23	setting	set	VERB
hjic-1161	256	24	up	up	ADP
hjic-1161	256	25	the	the	DET
hjic-1161	256	26	reaction	reaction	NOUN
hjic-1161	256	27	conditions	condition	NOUN
hjic-1161	256	28	for	for	ADP
hjic-1161	256	29	an	an	DET
hjic-1161	256	30	enzyme	enzyme	NOUN
hjic-1161	256	31	reaction	reaction	NOUN
hjic-1161	256	32	side	side	NOUN
hjic-1161	256	33	reactions	reaction	NOUN
hjic-1161	256	34	and	and	CCONJ
hjic-1161	256	35	their	their	PRON
hjic-1161	256	36	effect	effect	NOUN
hjic-1161	256	37	on	on	ADP
hjic-1161	256	38	the	the	DET
hjic-1161	256	39	reaction	reaction	NOUN
hjic-1161	256	40	scheme	scheme	NOUN
hjic-1161	256	41	.	.	PUNCT
hjic-1161	257	1	investigation	investigation	NOUN
hjic-1161	257	2	of	of	ADP
hjic-1161	257	3	the	the	DET
hjic-1161	257	4	kinetics	kinetic	NOUN
hjic-1161	257	5	of	of	ADP
hjic-1161	257	6	the	the	DET
hjic-1161	257	7	enzyme	enzyme	NOUN
hjic-1161	257	8	-	-	PUNCT
hjic-1161	257	9	catalysed	catalyse	VERB
hjic-1161	257	10	reaction	reaction	NOUN
hjic-1161	257	11	investigation	investigation	NOUN
hjic-1161	257	12	of	of	ADP
hjic-1161	257	13	the	the	DET
hjic-1161	257	14	operational	operational	ADJ
hjic-1161	257	15	stability	stability	NOUN
hjic-1161	257	16	of	of	ADP
hjic-1161	257	17	the	the	DET
hjic-1161	257	18	enzyme	enzyme	NOUN
hjic-1161	257	19	choosing	choose	VERB
hjic-1161	257	20	the	the	DET
hjic-1161	257	21	best	good	ADJ
hjic-1161	257	22	enzyme	enzyme	NOUN
hjic-1161	257	23	variant	variant	NOUN
hjic-1161	257	24	for	for	ADP
hjic-1161	257	25	the	the	DET
hjic-1161	257	26	reaction	reaction	NOUN
hjic-1161	257	27	conclusions	conclusion	NOUN