id	sid	tid	token	lemma	pos
hjic-1267	1	1	hungarian	hungarian	ADJ
hjic-1267	1	2	journal	journal	NOUN
hjic-1267	1	3	of	of	ADP
hjic-1267	1	4	industry	industry	NOUN
hjic-1267	1	5	and	and	CCONJ
hjic-1267	1	6	chemistry	chemistry	NOUN
hjic-1267	1	7	vol	vol	NOUN
hjic-1267	1	8	.	.	PUNCT
hjic-1267	2	1	53(2	53(2	NUM
hjic-1267	2	2	)	)	PUNCT
hjic-1267	2	3	pp	pp	ADV
hjic-1267	2	4	.	.	PUNCT
hjic-1267	3	1	49–53	49–53	NUM
hjic-1267	3	2	(	(	PUNCT
hjic-1267	3	3	2025	2025	NUM
hjic-1267	3	4	)	)	PUNCT
hjic-1267	3	5	hjic.mk.uni-pannon.hu	hjic.mk.uni-pannon.hu	NOUN
hjic-1267	3	6	doi	doi	NOUN
hjic-1267	3	7	:	:	PUNCT
hjic-1267	3	8	10.33927	10.33927	NUM
hjic-1267	3	9	/	/	SYM
hjic-1267	3	10	hjic-2025	hjic-2025	NOUN
hjic-1267	3	11	-	-	PUNCT
hjic-1267	3	12	17	17	NUM
hjic-1267	3	13	diastereoselective	diastereoselective	ADJ
hjic-1267	3	14	alkylation	alkylation	NOUN
hjic-1267	3	15	of	of	ADP
hjic-1267	3	16	4	4	NUM
hjic-1267	3	17	-	-	PUNCT
hjic-1267	3	18	methyl-5	methyl-5	NOUN
hjic-1267	3	19	-	-	PUNCT
hjic-1267	3	20	oxo-2	oxo-2	ADV
hjic-1267	3	21	-	-	PUNCT
hjic-1267	3	22	phenyl-1,3	phenyl-1,3	NOUN
hjic-1267	3	23	-	-	PUNCT
hjic-1267	3	24	oxazolidine-3	oxazolidine-3	NUM
hjic-1267	3	25	-	-	PUNCT
hjic-1267	3	26	carboxylate	carboxylate	NOUN
hjic-1267	3	27	and	and	CCONJ
hjic-1267	3	28	2	2	NUM
hjic-1267	3	29	-	-	PUNCT
hjic-1267	3	30	chloromethyl	chloromethyl	NOUN
hjic-1267	3	31	-	-	PUNCT
hjic-1267	3	32	isoindole-1,3	isoindole-1,3	NOUN
hjic-1267	3	33	-	-	PUNCT
hjic-1267	3	34	dione	dione	NOUN
hjic-1267	3	35	odey	odey	NOUN
hjic-1267	3	36	bsharat1	bsharat1	PUNCT
hjic-1267	3	37	*	*	PROPN
hjic-1267	3	38	1	1	NUM
hjic-1267	3	39	department	department	NOUN
hjic-1267	3	40	of	of	ADP
hjic-1267	3	41	chemistry	chemistry	NOUN
hjic-1267	3	42	,	,	PUNCT
hjic-1267	3	43	faculty	faculty	NOUN
hjic-1267	3	44	of	of	ADP
hjic-1267	3	45	sciences	science	NOUN
hjic-1267	3	46	,	,	PUNCT
hjic-1267	3	47	an	an	DET
hjic-1267	3	48	-	-	PUNCT
hjic-1267	3	49	najah	najah	ADJ
hjic-1267	3	50	national	national	ADJ
hjic-1267	3	51	university	university	NOUN
hjic-1267	3	52	,	,	PUNCT
hjic-1267	3	53	nablus	nablus	PROPN
hjic-1267	3	54	,	,	PUNCT
hjic-1267	3	55	p.o	p.o	PROPN
hjic-1267	3	56	.	.	PROPN
hjic-1267	3	57	box	box	PROPN
hjic-1267	3	58	7	7	NUM
hjic-1267	3	59	,	,	PUNCT
hjic-1267	3	60	palestine	palestine	PROPN
hjic-1267	3	61	asymmetric	asymmetric	ADJ
hjic-1267	3	62	synthesis	synthesis	NOUN
hjic-1267	3	63	,	,	PUNCT
hjic-1267	3	64	that	that	ADV
hjic-1267	3	65	is	is	ADV
hjic-1267	3	66	,	,	PUNCT
hjic-1267	3	67	diastereoselective	diastereoselective	ADJ
hjic-1267	3	68	alkylation	alkylation	NOUN
hjic-1267	3	69	of	of	ADP
hjic-1267	3	70	a	a	DET
hjic-1267	3	71	chiral	chiral	ADJ
hjic-1267	3	72	auxiliary	auxiliary	NOUN
hjic-1267	3	73	,	,	PUNCT
hjic-1267	3	74	is	be	AUX
hjic-1267	3	75	an	an	DET
hjic-1267	3	76	important	important	ADJ
hjic-1267	3	77	tool	tool	NOUN
hjic-1267	3	78	in	in	ADP
hjic-1267	3	79	organic	organic	ADJ
hjic-1267	3	80	synthesis	synthesis	NOUN
hjic-1267	3	81	.	.	PUNCT
hjic-1267	4	1	in	in	ADP
hjic-1267	4	2	this	this	DET
hjic-1267	4	3	work	work	NOUN
hjic-1267	4	4	,	,	PUNCT
hjic-1267	4	5	an	an	DET
hjic-1267	4	6	α	α	NOUN
hjic-1267	4	7	-	-	PUNCT
hjic-1267	4	8	methyl	methyl	ADJ
hjic-1267	4	9	,	,	PUNCT
hjic-1267	4	10	non	non	ADJ
hjic-1267	4	11	-	-	ADJ
hjic-1267	4	12	natural	natural	ADJ
hjic-1267	4	13	amino	amino	NOUN
hjic-1267	4	14	acid	acid	NOUN
hjic-1267	4	15	(	(	PUNCT
hjic-1267	4	16	nnaa	nnaa	NOUN
hjic-1267	4	17	)	)	PUNCT
hjic-1267	4	18	building	building	NOUN
hjic-1267	4	19	block	block	NOUN
hjic-1267	4	20	equipped	equip	VERB
hjic-1267	4	21	with	with	ADP
hjic-1267	4	22	a	a	DET
hjic-1267	4	23	phthalimide	phthalimide	NOUN
hjic-1267	4	24	group	group	NOUN
hjic-1267	4	25	tail	tail	NOUN
hjic-1267	4	26	was	be	AUX
hjic-1267	4	27	prepared	prepare	VERB
hjic-1267	4	28	.	.	PUNCT
hjic-1267	5	1	this	this	DET
hjic-1267	5	2	work	work	NOUN
hjic-1267	5	3	describes	describe	VERB
hjic-1267	5	4	the	the	DET
hjic-1267	5	5	generation	generation	NOUN
hjic-1267	5	6	of	of	ADP
hjic-1267	5	7	the	the	DET
hjic-1267	5	8	lithium	lithium	NOUN
hjic-1267	5	9	enolate	enolate	NOUN
hjic-1267	5	10	for	for	ADP
hjic-1267	5	11	an	an	DET
hjic-1267	5	12	oxazolidin-2	oxazolidin-2	NUM
hjic-1267	5	13	-	-	PUNCT
hjic-1267	5	14	one	one	NUM
hjic-1267	5	15	chiral	chiral	ADJ
hjic-1267	5	16	auxiliary	auxiliary	NOUN
hjic-1267	5	17	derived	derive	VERB
hjic-1267	5	18	from	from	ADP
hjic-1267	5	19	a	a	DET
hjic-1267	5	20	nnaa	nnaa	NOUN
hjic-1267	5	21	followed	follow	VERB
hjic-1267	5	22	by	by	ADP
hjic-1267	5	23	quenching	quench	VERB
hjic-1267	5	24	this	this	DET
hjic-1267	5	25	enolate	enolate	NOUN
hjic-1267	5	26	with	with	ADP
hjic-1267	5	27	2	2	NUM
hjic-1267	5	28	-	-	PUNCT
hjic-1267	5	29	chloromethyl	chloromethyl	NOUN
hjic-1267	5	30	-	-	PUNCT
hjic-1267	5	31	isoindole-1,3	isoindole-1,3	NOUN
hjic-1267	5	32	-	-	PUNCT
hjic-1267	5	33	dione	dione	NOUN
hjic-1267	5	34	to	to	PART
hjic-1267	5	35	provide	provide	VERB
hjic-1267	5	36	an	an	DET
hjic-1267	5	37	α	α	NUM
hjic-1267	5	38	-	-	PUNCT
hjic-1267	5	39	methyl	methyl	NOUN
hjic-1267	5	40	nnaa	nnaa	NOUN
hjic-1267	5	41	building	building	NOUN
hjic-1267	5	42	block	block	NOUN
hjic-1267	5	43	equipped	equip	VERB
hjic-1267	5	44	with	with	ADP
hjic-1267	5	45	a	a	DET
hjic-1267	5	46	phthalimide	phthalimide	NOUN
hjic-1267	5	47	group	group	NOUN
hjic-1267	5	48	in	in	ADP
hjic-1267	5	49	good	good	ADJ
hjic-1267	5	50	yield	yield	NOUN
hjic-1267	5	51	through	through	ADP
hjic-1267	5	52	a	a	DET
hjic-1267	5	53	multistep	multistep	ADJ
hjic-1267	5	54	synthesis	synthesis	NOUN
hjic-1267	5	55	with	with	ADP
hjic-1267	5	56	no	no	DET
hjic-1267	5	57	signs	sign	NOUN
hjic-1267	5	58	of	of	ADP
hjic-1267	5	59	any	any	DET
hjic-1267	5	60	minor	minor	ADJ
hjic-1267	5	61	diastereomers	diastereomer	NOUN
hjic-1267	5	62	.	.	PUNCT
hjic-1267	6	1	the	the	DET
hjic-1267	6	2	identity	identity	NOUN
hjic-1267	6	3	of	of	ADP
hjic-1267	6	4	this	this	DET
hjic-1267	6	5	compound	compound	NOUN
hjic-1267	6	6	was	be	AUX
hjic-1267	6	7	confirmed	confirm	VERB
hjic-1267	6	8	by	by	ADP
hjic-1267	6	9	1h	1h	NUM
hjic-1267	6	10	nmr	nmr	NOUN
hjic-1267	6	11	(	(	PUNCT
hjic-1267	6	12	proton	proton	NOUN
hjic-1267	6	13	nuclear	nuclear	ADJ
hjic-1267	6	14	magnetic	magnetic	ADJ
hjic-1267	6	15	resonance	resonance	NOUN
hjic-1267	6	16	)	)	PUNCT
hjic-1267	6	17	and	and	CCONJ
hjic-1267	6	18	13c	13c	NOUN
hjic-1267	6	19	nmr	nmr	NOUN
hjic-1267	6	20	(	(	PUNCT
hjic-1267	6	21	carbon-13	carbon-13	PROPN
hjic-1267	6	22	nuclear	nuclear	ADJ
hjic-1267	6	23	magnetic	magnetic	ADJ
hjic-1267	6	24	resonance	resonance	NOUN
hjic-1267	6	25	)	)	PUNCT
hjic-1267	6	26	spectroscopy	spectroscopy	NOUN
hjic-1267	6	27	.	.	PUNCT
hjic-1267	7	1	with	with	ADP
hjic-1267	7	2	the	the	DET
hjic-1267	7	3	availability	availability	NOUN
hjic-1267	7	4	of	of	ADP
hjic-1267	7	5	this	this	DET
hjic-1267	7	6	building	building	NOUN
hjic-1267	7	7	block	block	NOUN
hjic-1267	7	8	,	,	PUNCT
hjic-1267	7	9	peptides	peptide	NOUN
hjic-1267	7	10	can	can	AUX
hjic-1267	7	11	be	be	AUX
hjic-1267	7	12	produced	produce	VERB
hjic-1267	7	13	and	and	CCONJ
hjic-1267	7	14	evaluated	evaluate	VERB
hjic-1267	7	15	over	over	ADP
hjic-1267	7	16	a	a	DET
hjic-1267	7	17	variety	variety	NOUN
hjic-1267	7	18	of	of	ADP
hjic-1267	7	19	therapeutic	therapeutic	ADJ
hjic-1267	7	20	areas	area	NOUN
hjic-1267	7	21	in	in	ADP
hjic-1267	7	22	drug	drug	NOUN
hjic-1267	7	23	discovery	discovery	NOUN
hjic-1267	7	24	.	.	PUNCT
hjic-1267	8	1	keywords	keyword	NOUN
hjic-1267	8	2	:	:	PUNCT
hjic-1267	8	3	asymmetric	asymmetric	ADJ
hjic-1267	8	4	synthesis	synthesis	NOUN
hjic-1267	8	5	,	,	PUNCT
hjic-1267	8	6	diastereoselective	diastereoselective	ADJ
hjic-1267	8	7	alkylation	alkylation	NOUN
hjic-1267	8	8	,	,	PUNCT
hjic-1267	8	9	chiral	chiral	ADJ
hjic-1267	8	10	auxiliary	auxiliary	NOUN
hjic-1267	8	11	1	1	NUM
hjic-1267	8	12	.	.	PUNCT
hjic-1267	8	13	introduction	introduction	NOUN
hjic-1267	8	14	asymmetric	asymmetric	ADJ
hjic-1267	8	15	synthesis	synthesis	NOUN
hjic-1267	8	16	,	,	PUNCT
hjic-1267	8	17	namely	namely	ADV
hjic-1267	8	18	assembling	assemble	VERB
hjic-1267	8	19	complex	complex	ADJ
hjic-1267	8	20	molecules	molecule	NOUN
hjic-1267	8	21	as	as	ADP
hjic-1267	8	22	single	single	ADJ
hjic-1267	8	23	enantiomers	enantiomer	NOUN
hjic-1267	8	24	from	from	ADP
hjic-1267	8	25	relatively	relatively	ADV
hjic-1267	8	26	simple	simple	ADJ
hjic-1267	8	27	and	and	CCONJ
hjic-1267	8	28	readily	readily	ADV
hjic-1267	8	29	available	available	ADJ
hjic-1267	8	30	starting	start	VERB
hjic-1267	8	31	materials	material	NOUN
hjic-1267	8	32	,	,	PUNCT
hjic-1267	8	33	is	be	AUX
hjic-1267	8	34	an	an	DET
hjic-1267	8	35	important	important	ADJ
hjic-1267	8	36	tool	tool	NOUN
hjic-1267	8	37	in	in	ADP
hjic-1267	8	38	modern	modern	ADJ
hjic-1267	8	39	organic	organic	ADJ
hjic-1267	8	40	chemistry	chemistry	NOUN
hjic-1267	8	41	synthesis	synthesis	NOUN
hjic-1267	9	1	[	[	X
hjic-1267	9	2	1	1	NUM
hjic-1267	9	3	]	]	PUNCT
hjic-1267	9	4	.	.	PUNCT
hjic-1267	10	1	in	in	ADP
hjic-1267	10	2	the	the	DET
hjic-1267	10	3	pharmaceutical	pharmaceutical	NOUN
hjic-1267	10	4	industry	industry	NOUN
hjic-1267	10	5	,	,	PUNCT
hjic-1267	10	6	these	these	DET
hjic-1267	10	7	single	single	ADJ
hjic-1267	10	8	enantiomers	enantiomer	NOUN
hjic-1267	10	9	play	play	VERB
hjic-1267	10	10	an	an	DET
hjic-1267	10	11	important	important	ADJ
hjic-1267	10	12	rule	rule	NOUN
hjic-1267	10	13	in	in	ADP
hjic-1267	10	14	drug	drug	NOUN
hjic-1267	10	15	discovery	discovery	NOUN
hjic-1267	10	16	since	since	SCONJ
hjic-1267	10	17	almost	almost	ADV
hjic-1267	10	18	all	all	PRON
hjic-1267	10	19	newly	newly	ADV
hjic-1267	10	20	introduced	introduce	VERB
hjic-1267	10	21	chiral	chiral	ADJ
hjic-1267	10	22	drugs	drug	NOUN
hjic-1267	10	23	are	be	AUX
hjic-1267	10	24	marketed	market	VERB
hjic-1267	10	25	as	as	ADP
hjic-1267	10	26	single	single	ADJ
hjic-1267	10	27	enantiomers	enantiomer	NOUN
hjic-1267	10	28	[	[	X
hjic-1267	10	29	2	2	NUM
hjic-1267	10	30	]	]	PUNCT
hjic-1267	10	31	.	.	PUNCT
hjic-1267	11	1	one	one	NUM
hjic-1267	11	2	of	of	ADP
hjic-1267	11	3	the	the	DET
hjic-1267	11	4	most	most	ADV
hjic-1267	11	5	common	common	ADJ
hjic-1267	11	6	methods	method	NOUN
hjic-1267	11	7	for	for	ADP
hjic-1267	11	8	asymmetric	asymmetric	ADJ
hjic-1267	11	9	synthesis	synthesis	NOUN
hjic-1267	11	10	is	be	AUX
hjic-1267	11	11	the	the	DET
hjic-1267	11	12	use	use	NOUN
hjic-1267	11	13	of	of	ADP
hjic-1267	11	14	a	a	DET
hjic-1267	11	15	chiral	chiral	ADJ
hjic-1267	11	16	auxiliary	auxiliary	NOUN
hjic-1267	11	17	.	.	PUNCT
hjic-1267	12	1	in	in	ADP
hjic-1267	12	2	order	order	NOUN
hjic-1267	12	3	for	for	SCONJ
hjic-1267	12	4	the	the	DET
hjic-1267	12	5	application	application	NOUN
hjic-1267	12	6	of	of	ADP
hjic-1267	12	7	chiral	chiral	ADJ
hjic-1267	12	8	auxiliaries	auxiliary	NOUN
hjic-1267	12	9	to	to	PART
hjic-1267	12	10	be	be	AUX
hjic-1267	12	11	beneficial	beneficial	ADJ
hjic-1267	12	12	,	,	PUNCT
hjic-1267	12	13	three	three	NUM
hjic-1267	12	14	important	important	ADJ
hjic-1267	12	15	conditions	condition	NOUN
hjic-1267	12	16	must	must	AUX
hjic-1267	12	17	be	be	AUX
hjic-1267	12	18	met	meet	VERB
hjic-1267	12	19	:	:	PUNCT
hjic-1267	12	20	first	first	ADV
hjic-1267	12	21	,	,	PUNCT
hjic-1267	12	22	they	they	PRON
hjic-1267	12	23	should	should	AUX
hjic-1267	12	24	mediate	mediate	VERB
hjic-1267	12	25	a	a	DET
hjic-1267	12	26	highly	highly	ADV
hjic-1267	12	27	diastereoselective	diastereoselective	ADJ
hjic-1267	12	28	transformation	transformation	NOUN
hjic-1267	12	29	;	;	PUNCT
hjic-1267	12	30	second	second	X
hjic-1267	12	31	,	,	PUNCT
hjic-1267	12	32	they	they	PRON
hjic-1267	12	33	must	must	AUX
hjic-1267	12	34	be	be	AUX
hjic-1267	12	35	easily	easily	ADV
hjic-1267	12	36	removed	remove	VERB
hjic-1267	12	37	without	without	ADP
hjic-1267	12	38	racemization	racemization	NOUN
hjic-1267	12	39	of	of	ADP
hjic-1267	12	40	the	the	DET
hjic-1267	12	41	newly	newly	ADV
hjic-1267	12	42	created	create	VERB
hjic-1267	12	43	stereogenic	stereogenic	NOUN
hjic-1267	12	44	center(s	center(s	NOUN
hjic-1267	12	45	)	)	PUNCT
hjic-1267	12	46	;	;	PUNCT
hjic-1267	12	47	third	third	X
hjic-1267	12	48	,	,	PUNCT
hjic-1267	12	49	they	they	PRON
hjic-1267	12	50	need	need	VERB
hjic-1267	12	51	to	to	PART
hjic-1267	12	52	be	be	AUX
hjic-1267	12	53	readily	readily	ADV
hjic-1267	12	54	attached	attach	VERB
hjic-1267	12	55	in	in	ADP
hjic-1267	12	56	their	their	PRON
hjic-1267	12	57	enantiomerically	enantiomerically	ADV
hjic-1267	12	58	pure	pure	ADJ
hjic-1267	12	59	form	form	NOUN
hjic-1267	12	60	to	to	ADP
hjic-1267	12	61	the	the	DET
hjic-1267	12	62	substrate	substrate	NOUN
hjic-1267	12	63	.	.	PUNCT
hjic-1267	13	1	in	in	ADP
hjic-1267	13	2	the	the	DET
hjic-1267	13	3	literature	literature	NOUN
hjic-1267	13	4	,	,	PUNCT
hjic-1267	13	5	several	several	ADJ
hjic-1267	13	6	chiral	chiral	ADJ
hjic-1267	13	7	auxiliaries	auxiliary	NOUN
hjic-1267	13	8	that	that	PRON
hjic-1267	13	9	meet	meet	VERB
hjic-1267	13	10	these	these	DET
hjic-1267	13	11	requirements	requirement	NOUN
hjic-1267	13	12	have	have	AUX
hjic-1267	13	13	been	be	AUX
hjic-1267	13	14	developed	develop	VERB
hjic-1267	13	15	[	[	PUNCT
hjic-1267	13	16	3	3	NUM
hjic-1267	13	17	]	]	PUNCT
hjic-1267	13	18	,	,	PUNCT
hjic-1267	13	19	however	however	ADV
hjic-1267	13	20	,	,	PUNCT
hjic-1267	13	21	the	the	DET
hjic-1267	13	22	class	class	NOUN
hjic-1267	13	23	of	of	ADP
hjic-1267	13	24	chiral	chiral	ADJ
hjic-1267	13	25	oxazolidinones	oxazolidinone	NOUN
hjic-1267	13	26	developed	develop	VERB
hjic-1267	13	27	by	by	ADP
hjic-1267	13	28	david	david	PROPN
hjic-1267	13	29	evans	evans	PROPN
hjic-1267	13	30	have	have	AUX
hjic-1267	13	31	proven	prove	VERB
hjic-1267	13	32	to	to	PART
hjic-1267	13	33	be	be	AUX
hjic-1267	13	34	the	the	DET
hjic-1267	13	35	gold	gold	ADJ
hjic-1267	13	36	standard	standard	NOUN
hjic-1267	13	37	[	[	X
hjic-1267	13	38	4	4	NUM
hjic-1267	13	39	]	]	PUNCT
hjic-1267	13	40	.	.	PUNCT
hjic-1267	14	1	these	these	DET
hjic-1267	14	2	chiral	chiral	ADJ
hjic-1267	14	3	auxiliaries	auxiliary	NOUN
hjic-1267	14	4	have	have	AUX
hjic-1267	14	5	successfully	successfully	ADV
hjic-1267	14	6	directed	direct	VERB
hjic-1267	14	7	many	many	ADJ
hjic-1267	14	8	diastereoselective	diastereoselective	ADJ
hjic-1267	14	9	alkylations	alkylation	NOUN
hjic-1267	14	10	,	,	PUNCT
hjic-1267	14	11	α	α	NOUN
hjic-1267	14	12	-	-	PUNCT
hjic-1267	14	13	aminations	amination	NOUN
hjic-1267	14	14	,	,	PUNCT
hjic-1267	14	15	aldol	aldol	NOUN
hjic-1267	14	16	additions	addition	NOUN
hjic-1267	14	17	,	,	PUNCT
hjic-1267	14	18	diels	diel	NOUN
hjic-1267	14	19	–	–	PUNCT
hjic-1267	14	20	alder	alder	NOUN
hjic-1267	14	21	cycloadditions	cycloaddition	NOUN
hjic-1267	14	22	and	and	CCONJ
hjic-1267	14	23	michael	michael	PROPN
hjic-1267	14	24	additions	addition	NOUN
hjic-1267	14	25	.	.	PUNCT
hjic-1267	15	1	most	most	ADV
hjic-1267	15	2	importantly	importantly	ADV
hjic-1267	15	3	,	,	PUNCT
hjic-1267	15	4	the	the	DET
hjic-1267	15	5	products	product	NOUN
hjic-1267	15	6	of	of	ADP
hjic-1267	15	7	these	these	DET
hjic-1267	15	8	reactions	reaction	NOUN
hjic-1267	15	9	can	can	AUX
hjic-1267	15	10	be	be	AUX
hjic-1267	15	11	transformed	transform	VERB
hjic-1267	15	12	into	into	ADP
hjic-1267	15	13	useful	useful	ADJ
hjic-1267	15	14	enantiopure	enantiopure	NOUN
hjic-1267	15	15	intermediates	intermediate	NOUN
hjic-1267	15	16	that	that	PRON
hjic-1267	15	17	can	can	AUX
hjic-1267	15	18	be	be	AUX
hjic-1267	15	19	used	use	VERB
hjic-1267	15	20	in	in	ADP
hjic-1267	15	21	industry	industry	NOUN
hjic-1267	15	22	to	to	PART
hjic-1267	15	23	prepare	prepare	VERB
hjic-1267	15	24	received	receive	VERB
hjic-1267	15	25	:	:	PUNCT
hjic-1267	15	26	14	14	NUM
hjic-1267	15	27	june	june	PROPN
hjic-1267	15	28	2025	2025	NUM
hjic-1267	15	29	;	;	PUNCT
hjic-1267	15	30	revised	revise	VERB
hjic-1267	15	31	:	:	PUNCT
hjic-1267	15	32	2	2	NUM
hjic-1267	15	33	aug	aug	PROPN
hjic-1267	15	34	2025	2025	NUM
hjic-1267	15	35	;	;	PUNCT
hjic-1267	15	36	accepted	accept	VERB
hjic-1267	15	37	:	:	PUNCT
hjic-1267	15	38	8	8	NUM
hjic-1267	15	39	aug	aug	PROPN
hjic-1267	15	40	2025	2025	NUM
hjic-1267	15	41	*	*	NOUN
hjic-1267	15	42	correspondence	correspondence	NOUN
hjic-1267	15	43	:	:	PUNCT
hjic-1267	15	44	obsharat@najah.edu	obsharat@najah.edu	X
hjic-1267	15	45	drugs	drug	NOUN
hjic-1267	15	46	.	.	PUNCT
hjic-1267	16	1	compounds	compound	NOUN
hjic-1267	16	2	with	with	ADP
hjic-1267	16	3	an	an	DET
hjic-1267	16	4	oxazolidine	oxazolidine	NOUN
hjic-1267	16	5	ring	ring	NOUN
hjic-1267	16	6	are	be	AUX
hjic-1267	16	7	of	of	ADP
hjic-1267	16	8	great	great	ADJ
hjic-1267	16	9	importance	importance	NOUN
hjic-1267	16	10	due	due	ADP
hjic-1267	16	11	to	to	ADP
hjic-1267	16	12	their	their	PRON
hjic-1267	16	13	presence	presence	NOUN
hjic-1267	16	14	in	in	ADP
hjic-1267	16	15	several	several	ADJ
hjic-1267	16	16	biologically	biologically	ADV
hjic-1267	16	17	active	active	ADJ
hjic-1267	16	18	synthetic	synthetic	ADJ
hjic-1267	16	19	products	product	NOUN
hjic-1267	16	20	,	,	PUNCT
hjic-1267	16	21	for	for	ADP
hjic-1267	16	22	example	example	NOUN
hjic-1267	16	23	,	,	PUNCT
hjic-1267	16	24	linezolid	linezolid	PROPN
hjic-1267	16	25	,	,	PUNCT
hjic-1267	16	26	an	an	DET
hjic-1267	16	27	oxazolidin-2	oxazolidin-2	NUM
hjic-1267	16	28	-	-	SYM
hjic-1267	16	29	one	one	NUM
hjic-1267	16	30	,	,	PUNCT
hjic-1267	16	31	which	which	PRON
hjic-1267	16	32	is	be	AUX
hjic-1267	16	33	considered	consider	VERB
hjic-1267	16	34	to	to	PART
hjic-1267	16	35	set	set	VERB
hjic-1267	16	36	a	a	DET
hjic-1267	16	37	new	new	ADJ
hjic-1267	16	38	antimicrobial	antimicrobial	ADJ
hjic-1267	16	39	class	class	NOUN
hjic-1267	16	40	developed	develop	VERB
hjic-1267	16	41	over	over	ADP
hjic-1267	16	42	the	the	DET
hjic-1267	16	43	past	past	ADJ
hjic-1267	16	44	30	30	NUM
hjic-1267	16	45	years	year	NOUN
hjic-1267	16	46	(	(	PUNCT
hjic-1267	16	47	figure	figure	NOUN
hjic-1267	16	48	1	1	NUM
hjic-1267	16	49	)	)	PUNCT
hjic-1267	17	1	[	[	X
hjic-1267	17	2	5	5	NUM
hjic-1267	17	3	]	]	PUNCT
hjic-1267	17	4	.	.	PUNCT
hjic-1267	18	1	chiral	chiral	ADJ
hjic-1267	18	2	auxiliaries	auxiliary	NOUN
hjic-1267	18	3	were	be	AUX
hjic-1267	18	4	first	first	ADV
hjic-1267	18	5	discovered	discover	VERB
hjic-1267	18	6	and	and	CCONJ
hjic-1267	18	7	introduced	introduce	VERB
hjic-1267	18	8	by	by	ADP
hjic-1267	18	9	e.	e.	PROPN
hjic-1267	18	10	j.	j.	PROPN
hjic-1267	18	11	corey	corey	PROPN
hjic-1267	18	12	in	in	ADP
hjic-1267	18	13	1975	1975	NUM
hjic-1267	19	1	[	[	X
hjic-1267	19	2	6	6	NUM
hjic-1267	19	3	]	]	PUNCT
hjic-1267	19	4	using	use	VERB
hjic-1267	19	5	chiral	chiral	ADJ
hjic-1267	19	6	8	8	NUM
hjic-1267	19	7	-	-	PUNCT
hjic-1267	19	8	phenylmenthol	phenylmenthol	NOUN
hjic-1267	19	9	and	and	CCONJ
hjic-1267	19	10	followed	follow	VERB
hjic-1267	19	11	by	by	ADP
hjic-1267	19	12	the	the	DET
hjic-1267	19	13	discovery	discovery	NOUN
hjic-1267	19	14	of	of	ADP
hjic-1267	19	15	chiral	chiral	ADJ
hjic-1267	19	16	mandelic	mandelic	NOUN
hjic-1267	19	17	acid	acid	NOUN
hjic-1267	19	18	by	by	ADP
hjic-1267	19	19	b.	b.	PROPN
hjic-1267	19	20	m.	m.	PROPN
hjic-1267	19	21	trost	trost	PROPN
hjic-1267	20	1	[	[	X
hjic-1267	20	2	7	7	NUM
hjic-1267	20	3	]	]	PUNCT
hjic-1267	20	4	.	.	PUNCT
hjic-1267	21	1	as	as	SCONJ
hjic-1267	21	2	menthol	menthol	NOUN
hjic-1267	21	3	is	be	AUX
hjic-1267	21	4	difficult	difficult	ADJ
hjic-1267	21	5	to	to	PART
hjic-1267	21	6	synthesize	synthesize	VERB
hjic-1267	21	7	,	,	PUNCT
hjic-1267	21	8	trans-2	trans-2	NUM
hjic-1267	21	9	-	-	PUNCT
hjic-1267	21	10	phenyl-1	phenyl-1	NUM
hjic-1267	21	11	-	-	PUNCT
hjic-1267	21	12	cyclohexanol	cyclohexanol	NOUN
hjic-1267	21	13	was	be	AUX
hjic-1267	21	14	introduced	introduce	VERB
hjic-1267	21	15	by	by	ADP
hjic-1267	21	16	j.	j.	PROPN
hjic-1267	21	17	k.	k.	PROPN
hjic-1267	21	18	whitesell	whitesell	PROPN
hjic-1267	21	19	in	in	ADP
hjic-1267	21	20	1985	1985	NUM
hjic-1267	21	21	as	as	ADP
hjic-1267	21	22	an	an	DET
hjic-1267	21	23	alternative	alternative	NOUN
hjic-1267	21	24	[	[	X
hjic-1267	21	25	8	8	NUM
hjic-1267	21	26	]	]	PUNCT
hjic-1267	21	27	.	.	PUNCT
hjic-1267	22	1	undoubtedly	undoubtedly	ADV
hjic-1267	22	2	,	,	PUNCT
hjic-1267	22	3	the	the	DET
hjic-1267	22	4	most	most	ADV
hjic-1267	22	5	efficient	efficient	ADJ
hjic-1267	22	6	and	and	CCONJ
hjic-1267	22	7	frequently	frequently	ADV
hjic-1267	22	8	used	use	VERB
hjic-1267	22	9	chiral	chiral	ADJ
hjic-1267	22	10	auxiliaries	auxiliary	NOUN
hjic-1267	22	11	with	with	ADP
hjic-1267	22	12	prevalent	prevalent	ADJ
hjic-1267	22	13	applications	application	NOUN
hjic-1267	22	14	are	be	AUX
hjic-1267	22	15	the	the	DET
hjic-1267	22	16	chiral	chiral	ADJ
hjic-1267	22	17	oxazolidinones	oxazolidinone	NOUN
hjic-1267	22	18	developed	develop	VERB
hjic-1267	22	19	and	and	CCONJ
hjic-1267	22	20	reported	report	VERB
hjic-1267	22	21	by	by	ADP
hjic-1267	22	22	david	david	PROPN
hjic-1267	22	23	evans	evans	PROPN
hjic-1267	22	24	.	.	PUNCT
hjic-1267	23	1	oxazolidinones	oxazolidinone	NOUN
hjic-1267	23	2	are	be	AUX
hjic-1267	23	3	a	a	DET
hjic-1267	23	4	class	class	NOUN
hjic-1267	23	5	of	of	ADP
hjic-1267	23	6	compounds	compound	NOUN
hjic-1267	23	7	containing	contain	VERB
hjic-1267	23	8	2	2	NUM
hjic-1267	23	9	-	-	PUNCT
hjic-1267	23	10	oxazolidone	oxazolidone	NOUN
hjic-1267	23	11	,	,	PUNCT
hjic-1267	23	12	which	which	PRON
hjic-1267	23	13	is	be	AUX
hjic-1267	23	14	a	a	DET
hjic-1267	23	15	heterocyclic	heterocyclic	ADJ
hjic-1267	23	16	compound	compound	NOUN
hjic-1267	23	17	containing	contain	VERB
hjic-1267	23	18	both	both	CCONJ
hjic-1267	23	19	nitrogen	nitrogen	NOUN
hjic-1267	23	20	and	and	CCONJ
hjic-1267	23	21	oxygen	oxygen	NOUN
hjic-1267	23	22	in	in	ADP
hjic-1267	23	23	a	a	DET
hjic-1267	23	24	5	5	NUM
hjic-1267	23	25	-	-	PUNCT
hjic-1267	23	26	membered	membere	VERB
hjic-1267	23	27	ring	ring	NOUN
hjic-1267	23	28	usually	usually	ADV
hjic-1267	23	29	prepared	prepare	VERB
hjic-1267	23	30	from	from	ADP
hjic-1267	23	31	chiral	chiral	ADJ
hjic-1267	23	32	natural	natural	ADJ
hjic-1267	23	33	amino	amino	NOUN
hjic-1267	23	34	acids	acid	NOUN
hjic-1267	24	1	[	[	X
hjic-1267	24	2	9]-[15	9]-[15	X
hjic-1267	24	3	]	]	PUNCT
hjic-1267	24	4	.	.	PUNCT
hjic-1267	25	1	figure	figure	NOUN
hjic-1267	25	2	1	1	NUM
hjic-1267	25	3	:	:	PUNCT
hjic-1267	25	4	the	the	DET
hjic-1267	25	5	structure	structure	NOUN
hjic-1267	25	6	of	of	ADP
hjic-1267	25	7	linezoid	linezoid	NOUN
hjic-1267	25	8	https://doi.org/10.33927/hjic-2025-17	https://doi.org/10.33927/hjic-2025-17	PRON
hjic-1267	25	9	mailto:obsharat@najah.edu	mailto:obsharat@najah.edu	AUX
hjic-1267	25	10	bsharat	bsharat	PROPN
hjic-1267	25	11	hungarian	hungarian	ADJ
hjic-1267	25	12	journal	journal	PROPN
hjic-1267	25	13	of	of	ADP
hjic-1267	25	14	industry	industry	NOUN
hjic-1267	25	15	and	and	CCONJ
hjic-1267	25	16	chemistry	chemistry	NOUN
hjic-1267	26	1	50	50	NUM
hjic-1267	26	2	one	one	NUM
hjic-1267	26	3	of	of	ADP
hjic-1267	26	4	the	the	DET
hjic-1267	26	5	most	most	ADV
hjic-1267	26	6	effective	effective	ADJ
hjic-1267	26	7	and	and	CCONJ
hjic-1267	26	8	popular	popular	ADJ
hjic-1267	26	9	reactions	reaction	NOUN
hjic-1267	26	10	of	of	ADP
hjic-1267	26	11	acylated	acylated	ADJ
hjic-1267	26	12	evans	evan	NOUN
hjic-1267	26	13	’	'	PUNCT
hjic-1267	26	14	oxazolidinones	oxazolidinone	NOUN
hjic-1267	26	15	is	be	AUX
hjic-1267	26	16	diastereoselective	diastereoselective	ADJ
hjic-1267	26	17	alkylation	alkylation	NOUN
hjic-1267	26	18	.	.	PUNCT
hjic-1267	27	1	in	in	ADP
hjic-1267	27	2	spite	spite	NOUN
hjic-1267	27	3	of	of	ADP
hjic-1267	27	4	the	the	DET
hjic-1267	27	5	advantages	advantage	NOUN
hjic-1267	27	6	realized	realize	VERB
hjic-1267	27	7	for	for	ADP
hjic-1267	27	8	asymmetric	asymmetric	ADJ
hjic-1267	27	9	catalysis	catalysis	NOUN
hjic-1267	27	10	,	,	PUNCT
hjic-1267	27	11	organic	organic	ADJ
hjic-1267	27	12	synthetic	synthetic	ADJ
hjic-1267	27	13	chemists	chemist	NOUN
hjic-1267	27	14	frequently	frequently	ADV
hjic-1267	27	15	turn	turn	VERB
hjic-1267	27	16	to	to	ADP
hjic-1267	27	17	evans	evans	PROPN
hjic-1267	27	18	’	'	PUNCT
hjic-1267	27	19	methodology	methodology	NOUN
hjic-1267	27	20	,	,	PUNCT
hjic-1267	27	21	especially	especially	ADV
hjic-1267	27	22	when	when	SCONJ
hjic-1267	27	23	optically	optically	ADV
hjic-1267	27	24	pure	pure	ADJ
hjic-1267	27	25	carboxylic	carboxylic	ADJ
hjic-1267	27	26	acid	acid	NOUN
hjic-1267	27	27	derivatives	derivative	NOUN
hjic-1267	27	28	are	be	AUX
hjic-1267	27	29	required	require	VERB
hjic-1267	27	30	as	as	ADP
hjic-1267	27	31	final	final	ADJ
hjic-1267	27	32	products	product	NOUN
hjic-1267	27	33	or	or	CCONJ
hjic-1267	27	34	as	as	ADP
hjic-1267	27	35	intermediates	intermediate	NOUN
hjic-1267	27	36	.	.	PUNCT
hjic-1267	28	1	although	although	SCONJ
hjic-1267	28	2	it	it	PRON
hjic-1267	28	3	is	be	AUX
hjic-1267	28	4	not	not	PART
hjic-1267	28	5	as	as	ADV
hjic-1267	28	6	graceful	graceful	ADJ
hjic-1267	28	7	as	as	ADP
hjic-1267	28	8	asymmetric	asymmetric	ADJ
hjic-1267	28	9	catalysis	catalysis	NOUN
hjic-1267	28	10	,	,	PUNCT
hjic-1267	28	11	chiral	chiral	ADJ
hjic-1267	28	12	auxiliaries	auxiliary	NOUN
hjic-1267	28	13	continue	continue	VERB
hjic-1267	28	14	to	to	PART
hjic-1267	28	15	be	be	AUX
hjic-1267	28	16	very	very	ADV
hjic-1267	28	17	significant	significant	ADJ
hjic-1267	28	18	and	and	CCONJ
hjic-1267	28	19	frequently	frequently	ADV
hjic-1267	28	20	used	use	VERB
hjic-1267	28	21	for	for	ADP
hjic-1267	28	22	asymmetric	asymmetric	ADJ
hjic-1267	28	23	synthesis	synthesis	NOUN
hjic-1267	28	24	.	.	PUNCT
hjic-1267	29	1	in	in	ADP
hjic-1267	29	2	this	this	DET
hjic-1267	29	3	regard	regard	NOUN
hjic-1267	29	4	,	,	PUNCT
hjic-1267	29	5	the	the	DET
hjic-1267	29	6	total	total	ADJ
hjic-1267	29	7	synthesis	synthesis	NOUN
hjic-1267	29	8	of	of	ADP
hjic-1267	29	9	cytovaricin	cytovaricin	NOUN
hjic-1267	29	10	by	by	ADP
hjic-1267	29	11	evans	evans	PROPN
hjic-1267	29	12	et	et	PROPN
hjic-1267	29	13	al	al	PROPN
hjic-1267	29	14	.	.	PROPN
hjic-1267	29	15	is	be	AUX
hjic-1267	29	16	considered	consider	VERB
hjic-1267	29	17	as	as	ADP
hjic-1267	29	18	a	a	DET
hjic-1267	29	19	classic	classic	ADJ
hjic-1267	29	20	application	application	NOUN
hjic-1267	29	21	of	of	ADP
hjic-1267	29	22	oxazolidinones	oxazolidinone	NOUN
hjic-1267	29	23	as	as	ADP
hjic-1267	29	24	chiral	chiral	ADJ
hjic-1267	29	25	auxiliaries	auxiliary	NOUN
hjic-1267	29	26	for	for	ADP
hjic-1267	29	27	one	one	NUM
hjic-1267	29	28	asymmetric	asymmetric	ADJ
hjic-1267	29	29	alkylation	alkylation	NOUN
hjic-1267	29	30	and	and	CCONJ
hjic-1267	29	31	four	four	NUM
hjic-1267	29	32	asymmetric	asymmetric	ADJ
hjic-1267	29	33	aldol	aldol	NOUN
hjic-1267	29	34	reactions	reaction	NOUN
hjic-1267	29	35	required	require	VERB
hjic-1267	29	36	to	to	PART
hjic-1267	29	37	bring	bring	VERB
hjic-1267	29	38	about	about	ADP
hjic-1267	29	39	the	the	DET
hjic-1267	29	40	absolute	absolute	ADJ
hjic-1267	29	41	configuration	configuration	NOUN
hjic-1267	29	42	of	of	ADP
hjic-1267	29	43	nine	nine	NUM
hjic-1267	29	44	stereogenic	stereogenic	NOUN
hjic-1267	29	45	centers	center	NOUN
hjic-1267	29	46	present	present	ADJ
hjic-1267	29	47	in	in	ADP
hjic-1267	29	48	the	the	DET
hjic-1267	29	49	aforementioned	aforementioned	ADJ
hjic-1267	29	50	natural	natural	ADJ
hjic-1267	29	51	products	product	NOUN
hjic-1267	29	52	[	[	X
hjic-1267	29	53	16	16	NUM
hjic-1267	29	54	]	]	PUNCT
hjic-1267	29	55	.	.	PUNCT
hjic-1267	30	1	therapeutic	therapeutic	ADJ
hjic-1267	30	2	programs	program	NOUN
hjic-1267	30	3	based	base	VERB
hjic-1267	30	4	on	on	ADP
hjic-1267	30	5	peptides	peptide	NOUN
hjic-1267	30	6	have	have	AUX
hjic-1267	30	7	closed	close	VERB
hjic-1267	30	8	the	the	DET
hjic-1267	30	9	gap	gap	NOUN
hjic-1267	30	10	on	on	ADP
hjic-1267	30	11	those	those	PRON
hjic-1267	30	12	focused	focus	VERB
hjic-1267	30	13	on	on	ADP
hjic-1267	30	14	small	small	ADJ
hjic-1267	30	15	molecules	molecule	NOUN
hjic-1267	30	16	in	in	ADP
hjic-1267	30	17	pharma	pharma	NOUN
hjic-1267	30	18	.	.	PUNCT
hjic-1267	31	1	one	one	NUM
hjic-1267	31	2	modification	modification	NOUN
hjic-1267	31	3	that	that	PRON
hjic-1267	31	4	has	have	AUX
hjic-1267	31	5	extended	extend	VERB
hjic-1267	31	6	the	the	DET
hjic-1267	31	7	lifetime	lifetime	NOUN
hjic-1267	31	8	of	of	ADP
hjic-1267	31	9	peptides	peptide	NOUN
hjic-1267	31	10	is	be	AUX
hjic-1267	31	11	backbone	backbone	NOUN
hjic-1267	31	12	modification	modification	NOUN
hjic-1267	31	13	,	,	PUNCT
hjic-1267	31	14	including	include	VERB
hjic-1267	31	15	α	α	NOUN
hjic-1267	31	16	-	-	PUNCT
hjic-1267	31	17	methylation	methylation	NOUN
hjic-1267	31	18	using	use	VERB
hjic-1267	31	19	non	non	ADJ
hjic-1267	31	20	-	-	ADJ
hjic-1267	31	21	natural	natural	ADJ
hjic-1267	31	22	amino	amino	NOUN
hjic-1267	31	23	acids	acid	NOUN
hjic-1267	31	24	(	(	PUNCT
hjic-1267	31	25	nnaas	nnaas	NOUN
hjic-1267	31	26	)	)	PUNCT
hjic-1267	32	1	[	[	X
hjic-1267	32	2	17]-[19	17]-[19	NUM
hjic-1267	32	3	]	]	PUNCT
hjic-1267	32	4	.	.	PUNCT
hjic-1267	33	1	however	however	ADV
hjic-1267	33	2	,	,	PUNCT
hjic-1267	33	3	there	there	PRON
hjic-1267	33	4	are	be	VERB
hjic-1267	33	5	very	very	ADV
hjic-1267	33	6	few	few	ADJ
hjic-1267	33	7	commercially	commercially	ADV
hjic-1267	33	8	available	available	ADJ
hjic-1267	33	9	α	α	NOUN
hjic-1267	33	10	-	-	PUNCT
hjic-1267	33	11	methyl	methyl	ADJ
hjic-1267	33	12	amino	amino	NOUN
hjic-1267	33	13	acids	acid	NOUN
hjic-1267	33	14	,	,	PUNCT
hjic-1267	33	15	and	and	CCONJ
hjic-1267	33	16	they	they	PRON
hjic-1267	33	17	are	be	AUX
hjic-1267	33	18	extremely	extremely	ADV
hjic-1267	33	19	expensive	expensive	ADJ
hjic-1267	33	20	.	.	PUNCT
hjic-1267	34	1	the	the	DET
hjic-1267	34	2	development	development	NOUN
hjic-1267	34	3	of	of	ADP
hjic-1267	34	4	a	a	DET
hjic-1267	34	5	general	general	ADJ
hjic-1267	34	6	synthetic	synthetic	ADJ
hjic-1267	34	7	strategy	strategy	NOUN
hjic-1267	34	8	to	to	PART
hjic-1267	34	9	approach	approach	VERB
hjic-1267	34	10	a	a	DET
hjic-1267	34	11	wide	wide	ADJ
hjic-1267	34	12	variety	variety	NOUN
hjic-1267	34	13	of	of	ADP
hjic-1267	34	14	α	α	NOUN
hjic-1267	34	15	-	-	PUNCT
hjic-1267	34	16	methyl	methyl	NOUN
hjic-1267	34	17	nnaas	nnaas	NOUN
hjic-1267	34	18	would	would	AUX
hjic-1267	34	19	provide	provide	VERB
hjic-1267	34	20	a	a	DET
hjic-1267	34	21	significant	significant	ADJ
hjic-1267	34	22	step	step	NOUN
hjic-1267	34	23	forward	forward	ADV
hjic-1267	34	24	for	for	ADP
hjic-1267	34	25	drug	drug	NOUN
hjic-1267	34	26	discovery	discovery	NOUN
hjic-1267	34	27	by	by	ADP
hjic-1267	34	28	employing	employ	VERB
hjic-1267	34	29	peptide	peptide	NOUN
hjic-1267	34	30	-	-	PUNCT
hjic-1267	34	31	based	base	VERB
hjic-1267	34	32	candidates	candidate	NOUN
hjic-1267	34	33	.	.	PUNCT
hjic-1267	35	1	herein	herein	NOUN
hjic-1267	35	2	,	,	PUNCT
hjic-1267	35	3	a	a	DET
hjic-1267	35	4	new	new	ADJ
hjic-1267	35	5	protocol	protocol	NOUN
hjic-1267	35	6	for	for	ADP
hjic-1267	35	7	the	the	DET
hjic-1267	35	8	introduction	introduction	NOUN
hjic-1267	35	9	and	and	CCONJ
hjic-1267	35	10	diastereoselective	diastereoselective	ADJ
hjic-1267	35	11	alkylation	alkylation	NOUN
hjic-1267	35	12	of	of	ADP
hjic-1267	35	13	the	the	DET
hjic-1267	35	14	evans	evans	PROPN
hjic-1267	35	15	chiral	chiral	ADJ
hjic-1267	35	16	auxiliary	auxiliary	NOUN
hjic-1267	35	17	,	,	PUNCT
hjic-1267	35	18	namely	namely	ADV
hjic-1267	35	19	4	4	NUM
hjic-1267	35	20	-	-	PUNCT
hjic-1267	35	21	methyl-5	methyl-5	NOUN
hjic-1267	35	22	-	-	PUNCT
hjic-1267	35	23	oxo-2	oxo-2	NUM
hjic-1267	35	24	-	-	PUNCT
hjic-1267	35	25	phenyl-1,3oxazolidine-3	phenyl-1,3oxazolidine-3	NOUN
hjic-1267	35	26	-	-	NOUN
hjic-1267	35	27	carboxylate	carboxylate	NOUN
hjic-1267	35	28	with	with	ADP
hjic-1267	35	29	2	2	NUM
hjic-1267	35	30	-	-	PUNCT
hjic-1267	35	31	chloromethylisoindole-1,3	chloromethylisoindole-1,3	NOUN
hjic-1267	35	32	-	-	PUNCT
hjic-1267	35	33	dione	dione	NOUN
hjic-1267	35	34	,	,	PUNCT
hjic-1267	35	35	is	be	AUX
hjic-1267	35	36	presented	present	VERB
hjic-1267	35	37	.	.	PUNCT
hjic-1267	36	1	2	2	X
hjic-1267	36	2	.	.	X
hjic-1267	36	3	experimental	experimental	ADJ
hjic-1267	36	4	2.1	2.1	NUM
hjic-1267	36	5	.	.	PUNCT
hjic-1267	36	6	synthesis	synthesis	NOUN
hjic-1267	36	7	of	of	ADP
hjic-1267	36	8	2	2	NUM
hjic-1267	36	9	-	-	PUNCT
hjic-1267	36	10	chloromethyl	chloromethyl	NOUN
hjic-1267	36	11	-	-	PUNCT
hjic-1267	36	12	isoindole-1,3dione	isoindole-1,3dione	ADJ
hjic-1267	36	13	(	(	PUNCT
hjic-1267	36	14	compound	compound	NOUN
hjic-1267	36	15	(	(	PUNCT
hjic-1267	36	16	3	3	NUM
hjic-1267	36	17	)	)	PUNCT
hjic-1267	36	18	)	)	PUNCT
hjic-1267	36	19	compound	compound	NOUN
hjic-1267	36	20	(	(	PUNCT
hjic-1267	36	21	3	3	NUM
hjic-1267	36	22	)	)	PUNCT
hjic-1267	36	23	,	,	PUNCT
hjic-1267	36	24	that	that	ADV
hjic-1267	36	25	is	is	ADV
hjic-1267	36	26	,	,	PUNCT
hjic-1267	36	27	2	2	NUM
hjic-1267	36	28	-	-	PUNCT
hjic-1267	36	29	chloromethyl	chloromethyl	NOUN
hjic-1267	36	30	-	-	PUNCT
hjic-1267	36	31	isoindole-1,3dione	isoindole-1,3dione	ADJ
hjic-1267	36	32	,	,	PUNCT
hjic-1267	36	33	was	be	AUX
hjic-1267	36	34	prepared	prepare	VERB
hjic-1267	36	35	according	accord	VERB
hjic-1267	36	36	to	to	ADP
hjic-1267	36	37	a	a	DET
hjic-1267	36	38	method	method	NOUN
hjic-1267	36	39	found	find	VERB
hjic-1267	36	40	in	in	ADP
hjic-1267	36	41	the	the	DET
hjic-1267	36	42	literature	literature	NOUN
hjic-1267	36	43	[	[	X
hjic-1267	36	44	20	20	NUM
hjic-1267	36	45	]	]	PUNCT
hjic-1267	36	46	.	.	PUNCT
hjic-1267	37	1	a	a	DET
hjic-1267	37	2	solution	solution	NOUN
hjic-1267	37	3	of	of	ADP
hjic-1267	37	4	phthalimide	phthalimide	NOUN
hjic-1267	37	5	(	(	PUNCT
hjic-1267	37	6	1	1	NUM
hjic-1267	37	7	)	)	PUNCT
hjic-1267	37	8	and	and	CCONJ
hjic-1267	37	9	formaldehyde	formaldehyde	NOUN
hjic-1267	37	10	(	(	PUNCT
hjic-1267	37	11	40	40	NUM
hjic-1267	37	12	%	%	NOUN
hjic-1267	37	13	m	m	NOUN
hjic-1267	37	14	/	/	SYM
hjic-1267	37	15	v	v	ADJ
hjic-1267	37	16	aqueous	aqueous	ADJ
hjic-1267	37	17	solution	solution	NOUN
hjic-1267	37	18	)	)	PUNCT
hjic-1267	37	19	in	in	ADP
hjic-1267	37	20	water	water	NOUN
hjic-1267	37	21	(	(	PUNCT
hjic-1267	37	22	40	40	NUM
hjic-1267	37	23	ml	ml	NOUN
hjic-1267	37	24	)	)	PUNCT
hjic-1267	37	25	was	be	AUX
hjic-1267	37	26	stirred	stir	VERB
hjic-1267	37	27	at	at	ADP
hjic-1267	37	28	100	100	NUM
hjic-1267	37	29	°	°	ADP
hjic-1267	37	30	c	c	NOUN
hjic-1267	37	31	for	for	ADP
hjic-1267	37	32	4	4	NUM
hjic-1267	37	33	h.	h.	NOUN
hjic-1267	37	34	the	the	DET
hjic-1267	37	35	mixture	mixture	NOUN
hjic-1267	37	36	was	be	AUX
hjic-1267	37	37	cooled	cool	VERB
hjic-1267	37	38	to	to	ADP
hjic-1267	37	39	room	room	NOUN
hjic-1267	37	40	temperature	temperature	NOUN
hjic-1267	37	41	and	and	CCONJ
hjic-1267	37	42	filtered	filter	VERB
hjic-1267	37	43	.	.	PUNCT
hjic-1267	38	1	the	the	DET
hjic-1267	38	2	precipitate	precipitate	NOUN
hjic-1267	38	3	was	be	AUX
hjic-1267	38	4	washed	wash	VERB
hjic-1267	38	5	several	several	ADJ
hjic-1267	38	6	times	time	NOUN
hjic-1267	38	7	with	with	ADP
hjic-1267	38	8	water	water	NOUN
hjic-1267	38	9	and	and	CCONJ
hjic-1267	38	10	pentane	pentane	NOUN
hjic-1267	38	11	before	before	ADP
hjic-1267	38	12	being	be	AUX
hjic-1267	38	13	dried	dry	VERB
hjic-1267	38	14	to	to	PART
hjic-1267	38	15	provide	provide	VERB
hjic-1267	38	16	a	a	DET
hjic-1267	38	17	quantitative	quantitative	ADJ
hjic-1267	38	18	yield	yield	NOUN
hjic-1267	38	19	of	of	ADP
hjic-1267	38	20	2	2	NUM
hjic-1267	38	21	-	-	PUNCT
hjic-1267	38	22	hydroxymethyl	hydroxymethyl	NOUN
hjic-1267	38	23	-	-	PUNCT
hjic-1267	38	24	isoindole-1,3	isoindole-1,3	NOUN
hjic-1267	38	25	-	-	PUNCT
hjic-1267	38	26	dione	dione	NOUN
hjic-1267	38	27	(	(	PUNCT
hjic-1267	38	28	2	2	NUM
hjic-1267	38	29	)	)	PUNCT
hjic-1267	38	30	.	.	PUNCT
hjic-1267	39	1	in	in	ADP
hjic-1267	39	2	the	the	DET
hjic-1267	39	3	next	next	ADJ
hjic-1267	39	4	step	step	NOUN
hjic-1267	39	5	,	,	PUNCT
hjic-1267	39	6	compound	compound	NOUN
hjic-1267	39	7	(	(	PUNCT
hjic-1267	39	8	2	2	NUM
hjic-1267	39	9	)	)	PUNCT
hjic-1267	39	10	and	and	CCONJ
hjic-1267	39	11	thionyl	thionyl	VERB
hjic-1267	39	12	chloride	chloride	NOUN
hjic-1267	39	13	(	(	PUNCT
hjic-1267	39	14	socl2	socl2	NOUN
hjic-1267	39	15	)	)	PUNCT
hjic-1267	39	16	were	be	AUX
hjic-1267	39	17	stirred	stir	VERB
hjic-1267	39	18	under	under	ADP
hjic-1267	39	19	argon	argon	NOUN
hjic-1267	39	20	at	at	ADP
hjic-1267	39	21	75	75	NUM
hjic-1267	39	22	°	°	NOUN
hjic-1267	39	23	c	c	NOUN
hjic-1267	39	24	for	for	ADP
hjic-1267	39	25	4	4	NUM
hjic-1267	39	26	h	h	NOUN
hjic-1267	39	27	before	before	SCONJ
hjic-1267	39	28	the	the	DET
hjic-1267	39	29	mixture	mixture	NOUN
hjic-1267	39	30	was	be	AUX
hjic-1267	39	31	cooled	cool	VERB
hjic-1267	39	32	to	to	ADP
hjic-1267	39	33	room	room	NOUN
hjic-1267	39	34	temperature	temperature	NOUN
hjic-1267	39	35	.	.	PUNCT
hjic-1267	40	1	thionyl	thionyl	ADJ
hjic-1267	40	2	chloride	chloride	NOUN
hjic-1267	40	3	was	be	AUX
hjic-1267	40	4	removed	remove	VERB
hjic-1267	40	5	under	under	ADP
hjic-1267	40	6	reduced	reduced	ADJ
hjic-1267	40	7	pressure	pressure	NOUN
hjic-1267	40	8	.	.	PUNCT
hjic-1267	41	1	the	the	DET
hjic-1267	41	2	residue	residue	NOUN
hjic-1267	41	3	was	be	AUX
hjic-1267	41	4	diluted	dilute	VERB
hjic-1267	41	5	with	with	ADP
hjic-1267	41	6	dichloromethane	dichloromethane	NOUN
hjic-1267	41	7	(	(	PUNCT
hjic-1267	41	8	dcm	dcm	PROPN
hjic-1267	41	9	)	)	PUNCT
hjic-1267	41	10	and	and	CCONJ
hjic-1267	41	11	the	the	DET
hjic-1267	41	12	solvent	solvent	NOUN
hjic-1267	41	13	evaporated	evaporate	VERB
hjic-1267	41	14	off	off	ADP
hjic-1267	41	15	under	under	ADP
hjic-1267	41	16	reduced	reduced	ADJ
hjic-1267	41	17	pressure	pressure	NOUN
hjic-1267	41	18	.	.	PUNCT
hjic-1267	42	1	this	this	DET
hjic-1267	42	2	procedure	procedure	NOUN
hjic-1267	42	3	was	be	AUX
hjic-1267	42	4	repeated	repeat	VERB
hjic-1267	42	5	5	5	NUM
hjic-1267	42	6	times	time	NOUN
hjic-1267	42	7	to	to	PART
hjic-1267	42	8	afford	afford	VERB
hjic-1267	42	9	a	a	DET
hjic-1267	42	10	quantitative	quantitative	ADJ
hjic-1267	42	11	yield	yield	NOUN
hjic-1267	42	12	of	of	ADP
hjic-1267	42	13	2	2	NUM
hjic-1267	42	14	-	-	PUNCT
hjic-1267	42	15	chloromethylisoindole-1,3	chloromethylisoindole-1,3	NOUN
hjic-1267	42	16	-	-	PUNCT
hjic-1267	42	17	dione	dione	NOUN
hjic-1267	42	18	(	(	PUNCT
hjic-1267	42	19	3	3	NUM
hjic-1267	42	20	)	)	PUNCT
hjic-1267	42	21	.	.	PUNCT
hjic-1267	43	1	2.2	2.2	NUM
hjic-1267	43	2	.	.	PUNCT
hjic-1267	43	3	synthesis	synthesis	NOUN
hjic-1267	43	4	of	of	ADP
hjic-1267	43	5	(	(	PUNCT
hjic-1267	43	6	2r,4r)-4	2r,4r)-4	ADJ
hjic-1267	43	7	-	-	PUNCT
hjic-1267	43	8	methyl-5	methyl-5	NOUN
hjic-1267	43	9	-	-	PUNCT
hjic-1267	43	10	oxo-2phenyl-1,3	oxo-2phenyl-1,3	NOUN
hjic-1267	43	11	-	-	PUNCT
hjic-1267	43	12	oxazolidine-3	oxazolidine-3	NUM
hjic-1267	43	13	-	-	PUNCT
hjic-1267	43	14	carboxylate	carboxylate	NOUN
hjic-1267	43	15	(	(	PUNCT
hjic-1267	43	16	compound	compound	NOUN
hjic-1267	43	17	(	(	PUNCT
hjic-1267	43	18	6	6	NUM
hjic-1267	43	19	)	)	PUNCT
hjic-1267	43	20	)	)	PUNCT
hjic-1267	43	21	legend	legend	NOUN
hjic-1267	43	22	:	:	PUNCT
hjic-1267	43	23	compound	compound	NOUN
hjic-1267	43	24	(	(	PUNCT
hjic-1267	43	25	6	6	NUM
hjic-1267	43	26	)	)	PUNCT
hjic-1267	43	27	,	,	PUNCT
hjic-1267	43	28	namely	namely	ADV
hjic-1267	43	29	(	(	PUNCT
hjic-1267	43	30	2r,4r)-4	2r,4r)-4	ADJ
hjic-1267	43	31	-	-	PUNCT
hjic-1267	43	32	methyl-5oxo-2	methyl-5oxo-2	NOUN
hjic-1267	43	33	-	-	PUNCT
hjic-1267	43	34	phenyl-1,3	phenyl-1,3	NOUN
hjic-1267	43	35	-	-	PUNCT
hjic-1267	43	36	oxazolidine-3	oxazolidine-3	NUM
hjic-1267	43	37	-	-	PUNCT
hjic-1267	43	38	carboxylate	carboxylate	NOUN
hjic-1267	43	39	,	,	PUNCT
hjic-1267	43	40	was	be	AUX
hjic-1267	43	41	synthesized	synthesize	VERB
hjic-1267	43	42	according	accord	VERB
hjic-1267	43	43	to	to	ADP
hjic-1267	43	44	a	a	DET
hjic-1267	43	45	method	method	NOUN
hjic-1267	43	46	found	find	VERB
hjic-1267	43	47	in	in	ADP
hjic-1267	43	48	the	the	DET
hjic-1267	43	49	literature	literature	NOUN
hjic-1267	43	50	[	[	X
hjic-1267	43	51	21	21	NUM
hjic-1267	43	52	]	]	PUNCT
hjic-1267	43	53	.	.	PUNCT
hjic-1267	44	1	cyclization	cyclization	NOUN
hjic-1267	44	2	of	of	ADP
hjic-1267	44	3	benzyloxycarbonyl	benzyloxycarbonyl	NOUN
hjic-1267	44	4	(	(	PUNCT
hjic-1267	44	5	cbz)-protected	cbz)-protecte	VERB
hjic-1267	44	6	(	(	PUNCT
hjic-1267	44	7	d	d	NOUN
hjic-1267	44	8	)	)	PUNCT
hjic-1267	44	9	alanine	alanine	NOUN
hjic-1267	44	10	(	(	PUNCT
hjic-1267	44	11	4	4	NUM
hjic-1267	44	12	)	)	PUNCT
hjic-1267	44	13	with	with	ADP
hjic-1267	44	14	benzaldehyde	benzaldehyde	NOUN
hjic-1267	44	15	dimethyl	dimethyl	NOUN
hjic-1267	44	16	acetal	acetal	NOUN
hjic-1267	44	17	(	(	PUNCT
hjic-1267	44	18	5	5	NUM
hjic-1267	44	19	)	)	PUNCT
hjic-1267	44	20	provided	provide	VERB
hjic-1267	44	21	compound	compound	NOUN
hjic-1267	44	22	(	(	PUNCT
hjic-1267	44	23	6	6	NUM
hjic-1267	44	24	)	)	PUNCT
hjic-1267	44	25	as	as	ADP
hjic-1267	44	26	a	a	DET
hjic-1267	44	27	single	single	ADJ
hjic-1267	44	28	isomer	isomer	NOUN
hjic-1267	44	29	by	by	ADP
hjic-1267	44	30	slowly	slowly	ADV
hjic-1267	44	31	adding	add	VERB
hjic-1267	44	32	hexane	hexane	NOUN
hjic-1267	44	33	over	over	ADP
hjic-1267	44	34	6	6	NUM
hjic-1267	44	35	hours	hour	NOUN
hjic-1267	44	36	to	to	PART
hjic-1267	44	37	crash	crash	VERB
hjic-1267	44	38	out	out	ADP
hjic-1267	44	39	the	the	DET
hjic-1267	44	40	product	product	NOUN
hjic-1267	44	41	.	.	PUNCT
hjic-1267	45	1	more	more	ADV
hjic-1267	45	2	specifically	specifically	ADV
hjic-1267	45	3	,	,	PUNCT
hjic-1267	45	4	in	in	ADP
hjic-1267	45	5	a	a	DET
hjic-1267	45	6	dry	dry	ADJ
hjic-1267	45	7	flask	flask	NOUN
hjic-1267	45	8	under	under	ADP
hjic-1267	45	9	n2	n2	ADJ
hjic-1267	45	10	,	,	PUNCT
hjic-1267	45	11	cbz	cbz	PROPN
hjic-1267	45	12	-	-	PUNCT
hjic-1267	45	13	d	d	NOUN
hjic-1267	45	14	-	-	NOUN
hjic-1267	45	15	alanine	alanine	NOUN
hjic-1267	45	16	(	(	PUNCT
hjic-1267	45	17	4	4	NUM
hjic-1267	45	18	)	)	PUNCT
hjic-1267	45	19	(	(	PUNCT
hjic-1267	45	20	1.000	1.000	NUM
hjic-1267	45	21	equiv	equiv	NOUN
hjic-1267	45	22	.	.	PUNCT
hjic-1267	45	23	)	)	PUNCT
hjic-1267	46	1	and	and	CCONJ
hjic-1267	46	2	compound	compound	NOUN
hjic-1267	46	3	(	(	PUNCT
hjic-1267	46	4	5	5	NUM
hjic-1267	46	5	)	)	PUNCT
hjic-1267	46	6	(	(	PUNCT
hjic-1267	46	7	1.025	1.025	NUM
hjic-1267	46	8	equiv	equiv	NOUN
hjic-1267	46	9	.	.	PUNCT
hjic-1267	46	10	)	)	PUNCT
hjic-1267	46	11	were	be	AUX
hjic-1267	46	12	dissolved	dissolve	VERB
hjic-1267	46	13	in	in	ADP
hjic-1267	46	14	dry	dry	ADJ
hjic-1267	46	15	tetrahydrofuran	tetrahydrofuran	NOUN
hjic-1267	46	16	(	(	PUNCT
hjic-1267	46	17	thf	thf	NOUN
hjic-1267	46	18	)	)	PUNCT
hjic-1267	46	19	before	before	ADP
hjic-1267	46	20	being	be	AUX
hjic-1267	46	21	cooled	cool	VERB
hjic-1267	46	22	to	to	ADP
hjic-1267	46	23	0	0	NUM
hjic-1267	46	24	°	°	NUM
hjic-1267	46	25	c	c	NOUN
hjic-1267	46	26	.	.	PUNCT
hjic-1267	47	1	socl2	socl2	NOUN
hjic-1267	47	2	(	(	PUNCT
hjic-1267	47	3	1.100	1.100	NUM
hjic-1267	47	4	equiv	equiv	NOUN
hjic-1267	47	5	.	.	PUNCT
hjic-1267	47	6	)	)	PUNCT
hjic-1267	47	7	was	be	AUX
hjic-1267	47	8	added	add	VERB
hjic-1267	47	9	dropwise	dropwise	NOUN
hjic-1267	47	10	and	and	CCONJ
hjic-1267	47	11	after	after	ADP
hjic-1267	47	12	having	having	AUX
hjic-1267	47	13	been	be	AUX
hjic-1267	47	14	stirred	stir	VERB
hjic-1267	47	15	for	for	ADP
hjic-1267	47	16	10	10	NUM
hjic-1267	47	17	mins	min	NOUN
hjic-1267	47	18	.	.	PUNCT
hjic-1267	48	1	zncl2	zncl2	NOUN
hjic-1267	48	2	(	(	PUNCT
hjic-1267	48	3	1.100	1.100	NUM
hjic-1267	48	4	equiv	equiv	NOUN
hjic-1267	48	5	.	.	PUNCT
hjic-1267	48	6	)	)	PUNCT
hjic-1267	48	7	was	be	AUX
hjic-1267	48	8	added	add	VERB
hjic-1267	48	9	then	then	ADV
hjic-1267	48	10	the	the	DET
hjic-1267	48	11	solution	solution	NOUN
hjic-1267	48	12	further	far	ADV
hjic-1267	48	13	stirred	stir	VERB
hjic-1267	48	14	for	for	ADP
hjic-1267	48	15	4	4	NUM
hjic-1267	48	16	h	h	NOUN
hjic-1267	48	17	at	at	ADP
hjic-1267	48	18	0	0	NUM
hjic-1267	48	19	°	°	NOUN
hjic-1267	48	20	c	c	NOUN
hjic-1267	48	21	.	.	PUNCT
hjic-1267	49	1	the	the	DET
hjic-1267	49	2	reaction	reaction	NOUN
hjic-1267	49	3	was	be	AUX
hjic-1267	49	4	quenched	quench	VERB
hjic-1267	49	5	with	with	ADP
hjic-1267	49	6	the	the	DET
hjic-1267	49	7	dropwise	dropwise	NOUN
hjic-1267	49	8	addition	addition	NOUN
hjic-1267	49	9	of	of	ADP
hjic-1267	49	10	ice	ice	NOUN
hjic-1267	49	11	water	water	NOUN
hjic-1267	49	12	,	,	PUNCT
hjic-1267	49	13	followed	follow	VERB
hjic-1267	49	14	by	by	ADP
hjic-1267	49	15	the	the	DET
hjic-1267	49	16	addition	addition	NOUN
hjic-1267	49	17	of	of	ADP
hjic-1267	49	18	sodium	sodium	NOUN
hjic-1267	49	19	bicarbonate	bicarbonate	NOUN
hjic-1267	49	20	(	(	PUNCT
hjic-1267	49	21	nahco3	nahco3	ADJ
hjic-1267	49	22	)	)	PUNCT
hjic-1267	49	23	solution	solution	NOUN
hjic-1267	49	24	until	until	SCONJ
hjic-1267	49	25	the	the	DET
hjic-1267	49	26	ph	ph	NOUN
hjic-1267	49	27	became	become	VERB
hjic-1267	49	28	equal	equal	ADJ
hjic-1267	49	29	to	to	ADP
hjic-1267	49	30	4	4	NUM
hjic-1267	49	31	.	.	PUNCT
hjic-1267	50	1	the	the	DET
hjic-1267	50	2	mixture	mixture	NOUN
hjic-1267	50	3	was	be	AUX
hjic-1267	50	4	diluted	dilute	VERB
hjic-1267	50	5	in	in	ADP
hjic-1267	50	6	water	water	NOUN
hjic-1267	50	7	and	and	CCONJ
hjic-1267	50	8	extracted	extract	VERB
hjic-1267	50	9	with	with	ADP
hjic-1267	50	10	ether	ether	NOUN
hjic-1267	50	11	three	three	NUM
hjic-1267	50	12	times	time	NOUN
hjic-1267	50	13	before	before	SCONJ
hjic-1267	50	14	the	the	DET
hjic-1267	50	15	organic	organic	ADJ
hjic-1267	50	16	layers	layer	NOUN
hjic-1267	50	17	were	be	AUX
hjic-1267	50	18	washed	wash	VERB
hjic-1267	50	19	with	with	ADP
hjic-1267	50	20	brine	brine	NOUN
hjic-1267	50	21	,	,	PUNCT
hjic-1267	50	22	dried	dry	VERB
hjic-1267	50	23	over	over	ADP
hjic-1267	50	24	anhydrous	anhydrous	ADJ
hjic-1267	50	25	sodium	sodium	NOUN
hjic-1267	50	26	sulphate	sulphate	NOUN
hjic-1267	50	27	(	(	PUNCT
hjic-1267	50	28	na2so4	na2so4	NOUN
hjic-1267	50	29	)	)	PUNCT
hjic-1267	50	30	and	and	CCONJ
hjic-1267	50	31	evaporated	evaporate	VERB
hjic-1267	50	32	to	to	PART
hjic-1267	50	33	dryness	dryness	VERB
hjic-1267	50	34	in	in	ADP
hjic-1267	50	35	vacuo	vacuo	PROPN
hjic-1267	50	36	.	.	PUNCT
hjic-1267	51	1	the	the	DET
hjic-1267	51	2	crude	crude	ADJ
hjic-1267	51	3	product	product	NOUN
hjic-1267	51	4	was	be	AUX
hjic-1267	51	5	dissolved	dissolve	VERB
hjic-1267	51	6	in	in	ADP
hjic-1267	51	7	the	the	DET
hjic-1267	51	8	minimum	minimum	ADJ
hjic-1267	51	9	volume	volume	NOUN
hjic-1267	51	10	of	of	ADP
hjic-1267	51	11	ether	ether	NOUN
hjic-1267	51	12	,	,	PUNCT
hjic-1267	51	13	cooled	cool	VERB
hjic-1267	51	14	to	to	ADP
hjic-1267	51	15	room	room	NOUN
hjic-1267	51	16	temperature	temperature	NOUN
hjic-1267	51	17	and	and	CCONJ
hjic-1267	51	18	the	the	DET
hjic-1267	51	19	product	product	NOUN
hjic-1267	51	20	precipitated	precipitate	VERB
hjic-1267	51	21	by	by	ADP
hjic-1267	51	22	the	the	DET
hjic-1267	51	23	dropwise	dropwise	NOUN
hjic-1267	51	24	addition	addition	NOUN
hjic-1267	51	25	of	of	ADP
hjic-1267	51	26	hexane	hexane	NOUN
hjic-1267	51	27	over	over	ADP
hjic-1267	51	28	6	6	NUM
hjic-1267	51	29	hours	hour	NOUN
hjic-1267	51	30	resulting	result	VERB
hjic-1267	51	31	in	in	ADP
hjic-1267	51	32	a	a	DET
hjic-1267	51	33	yield	yield	NOUN
hjic-1267	51	34	of	of	ADP
hjic-1267	51	35	56	56	NUM
hjic-1267	51	36	%	%	NOUN
hjic-1267	51	37	.	.	PUNCT
hjic-1267	52	1	2.3	2.3	NUM
hjic-1267	52	2	.	.	PUNCT
hjic-1267	53	1	asymmetric	asymmetric	ADJ
hjic-1267	53	2	alkylation	alkylation	NOUN
hjic-1267	53	3	between	between	ADP
hjic-1267	53	4	compound	compound	NOUN
hjic-1267	53	5	(	(	PUNCT
hjic-1267	53	6	6	6	NUM
hjic-1267	53	7	)	)	PUNCT
hjic-1267	53	8	and	and	CCONJ
hjic-1267	53	9	compound	compound	NOUN
hjic-1267	53	10	(	(	PUNCT
hjic-1267	53	11	3	3	NUM
hjic-1267	53	12	)	)	PUNCT
hjic-1267	53	13	to	to	PART
hjic-1267	53	14	offer	offer	VERB
hjic-1267	53	15	produce	produce	VERB
hjic-1267	53	16	compound	compound	NOUN
hjic-1267	53	17	(	(	PUNCT
hjic-1267	53	18	7	7	NUM
hjic-1267	53	19	)	)	PUNCT
hjic-1267	53	20	below	below	ADP
hjic-1267	53	21	the	the	DET
hjic-1267	53	22	synthesis	synthesis	NOUN
hjic-1267	53	23	of	of	ADP
hjic-1267	53	24	compound	compound	NOUN
hjic-1267	53	25	(	(	PUNCT
hjic-1267	53	26	7	7	NUM
hjic-1267	53	27	)	)	PUNCT
hjic-1267	53	28	is	be	AUX
hjic-1267	53	29	described	describe	VERB
hjic-1267	53	30	.	.	PUNCT
hjic-1267	54	1	in	in	ADP
hjic-1267	54	2	a	a	DET
hjic-1267	54	3	dry	dry	ADJ
hjic-1267	54	4	flask	flask	NOUN
hjic-1267	54	5	under	under	ADP
hjic-1267	54	6	n2	n2	ADJ
hjic-1267	54	7	,	,	PUNCT
hjic-1267	54	8	compound	compound	NOUN
hjic-1267	54	9	(	(	PUNCT
hjic-1267	54	10	6	6	NUM
hjic-1267	54	11	)	)	PUNCT
hjic-1267	54	12	(	(	PUNCT
hjic-1267	54	13	9.2	9.2	NUM
hjic-1267	54	14	g	g	NOUN
hjic-1267	54	15	,	,	PUNCT
hjic-1267	54	16	29.6	29.6	NUM
hjic-1267	54	17	mmol	mmol	NOUN
hjic-1267	54	18	,	,	PUNCT
hjic-1267	54	19	1.000	1.000	NUM
hjic-1267	54	20	equiv	equiv	NOUN
hjic-1267	54	21	.	.	PUNCT
hjic-1267	54	22	)	)	PUNCT
hjic-1267	54	23	was	be	AUX
hjic-1267	54	24	dissolved	dissolve	VERB
hjic-1267	54	25	in	in	ADP
hjic-1267	54	26	dry	dry	ADJ
hjic-1267	54	27	thf	thf	NOUN
hjic-1267	54	28	(	(	PUNCT
hjic-1267	54	29	144	144	NUM
hjic-1267	54	30	ml	ml	NOUN
hjic-1267	54	31	)	)	PUNCT
hjic-1267	54	32	and	and	CCONJ
hjic-1267	54	33	n	n	CCONJ
hjic-1267	54	34	-	-	PUNCT
hjic-1267	54	35	methyl-2	methyl-2	NOUN
hjic-1267	54	36	-	-	NOUN
hjic-1267	54	37	pyrrolidone	pyrrolidone	NOUN
hjic-1267	54	38	(	(	PUNCT
hjic-1267	54	39	nmp	nmp	PROPN
hjic-1267	54	40	)	)	PUNCT
hjic-1267	54	41	(	(	PUNCT
hjic-1267	54	42	24	24	NUM
hjic-1267	54	43	ml	ml	NOUN
hjic-1267	54	44	)	)	PUNCT
hjic-1267	54	45	before	before	SCONJ
hjic-1267	54	46	the	the	DET
hjic-1267	54	47	solution	solution	NOUN
hjic-1267	54	48	was	be	AUX
hjic-1267	54	49	cooled	cool	VERB
hjic-1267	54	50	to	to	ADP
hjic-1267	54	51	-78	-78	NOUN
hjic-1267	54	52	°	°	PROPN
hjic-1267	54	53	c	c	X
hjic-1267	54	54	.	.	PUNCT
hjic-1267	55	1	lithium	lithium	NOUN
hjic-1267	55	2	bis(trimethylsilyl)amide	bis(trimethylsilyl)amide	NUM
hjic-1267	55	3	(	(	PUNCT
hjic-1267	55	4	lihmds	lihmds	NOUN
hjic-1267	55	5	)	)	PUNCT
hjic-1267	55	6	(	(	PUNCT
hjic-1267	55	7	1.0	1.0	NUM
hjic-1267	55	8	m	m	NOUN
hjic-1267	55	9	)	)	PUNCT
hjic-1267	55	10	in	in	ADP
hjic-1267	55	11	thf	thf	NOUN
hjic-1267	55	12	(	(	PUNCT
hjic-1267	55	13	30.8	30.8	NUM
hjic-1267	55	14	ml	ml	NOUN
hjic-1267	55	15	,	,	PUNCT
hjic-1267	55	16	30.8	30.8	NUM
hjic-1267	55	17	mmol	mmol	NOUN
hjic-1267	55	18	,	,	PUNCT
hjic-1267	55	19	1.300	1.300	NUM
hjic-1267	55	20	equiv	equiv	NOUN
hjic-1267	55	21	.	.	PUNCT
hjic-1267	55	22	)	)	PUNCT
hjic-1267	56	1	was	be	AUX
hjic-1267	56	2	added	add	VERB
hjic-1267	56	3	dropwise	dropwise	NOUN
hjic-1267	56	4	to	to	ADP
hjic-1267	56	5	the	the	DET
hjic-1267	56	6	solution	solution	NOUN
hjic-1267	56	7	and	and	CCONJ
hjic-1267	56	8	having	having	AUX
hjic-1267	56	9	been	be	AUX
hjic-1267	56	10	stirred	stir	VERB
hjic-1267	56	11	for	for	ADP
hjic-1267	56	12	10	10	NUM
hjic-1267	56	13	mins	min	NOUN
hjic-1267	56	14	.	.	PUNCT
hjic-1267	56	15	,	,	PUNCT
hjic-1267	56	16	compound	compound	NOUN
hjic-1267	56	17	(	(	PUNCT
hjic-1267	56	18	3	3	NUM
hjic-1267	56	19	)	)	PUNCT
hjic-1267	56	20	(	(	PUNCT
hjic-1267	56	21	13.9	13.9	NUM
hjic-1267	56	22	g	g	NOUN
hjic-1267	56	23	,	,	PUNCT
hjic-1267	56	24	71.1	71.1	NUM
hjic-1267	56	25	mmol	mmol	NOUN
hjic-1267	56	26	,	,	PUNCT
hjic-1267	56	27	3.000	3.000	NUM
hjic-1267	56	28	equiv	equiv	NOUN
hjic-1267	56	29	.	.	PUNCT
hjic-1267	56	30	)	)	PUNCT
hjic-1267	56	31	was	be	AUX
hjic-1267	56	32	added	add	VERB
hjic-1267	56	33	dropwise	dropwise	NOUN
hjic-1267	56	34	.	.	PUNCT
hjic-1267	57	1	the	the	DET
hjic-1267	57	2	reaction	reaction	NOUN
hjic-1267	57	3	was	be	AUX
hjic-1267	57	4	allowed	allow	VERB
hjic-1267	57	5	to	to	PART
hjic-1267	57	6	warm	warm	VERB
hjic-1267	57	7	up	up	ADP
hjic-1267	57	8	gradually	gradually	ADV
hjic-1267	57	9	to	to	PART
hjic-1267	57	10	room	room	VERB
hjic-1267	57	11	temperature	temperature	NOUN
hjic-1267	57	12	over	over	ADP
hjic-1267	57	13	18	18	NUM
hjic-1267	57	14	h	h	NOUN
hjic-1267	57	15	and	and	CCONJ
hjic-1267	57	16	quenched	quench	VERB
hjic-1267	57	17	with	with	ADP
hjic-1267	57	18	an	an	DET
hjic-1267	57	19	ammonium	ammonium	NOUN
hjic-1267	57	20	chloride	chloride	NOUN
hjic-1267	57	21	(	(	PUNCT
hjic-1267	57	22	nh4cl	nh4cl	NOUN
hjic-1267	57	23	)	)	PUNCT
hjic-1267	57	24	solution	solution	NOUN
hjic-1267	57	25	before	before	ADP
hjic-1267	57	26	being	be	AUX
hjic-1267	57	27	diluted	dilute	VERB
hjic-1267	57	28	with	with	ADP
hjic-1267	57	29	h2o	h2o	NOUN
hjic-1267	57	30	and	and	CCONJ
hjic-1267	57	31	extracted	extract	VERB
hjic-1267	57	32	with	with	ADP
hjic-1267	57	33	dcm	dcm	PROPN
hjic-1267	57	34	(	(	PUNCT
hjic-1267	57	35	3x	3x	NUM
hjic-1267	57	36	)	)	PUNCT
hjic-1267	57	37	.	.	PUNCT
hjic-1267	58	1	the	the	DET
hjic-1267	58	2	organic	organic	ADJ
hjic-1267	58	3	layers	layer	NOUN
hjic-1267	58	4	were	be	AUX
hjic-1267	58	5	combined	combine	VERB
hjic-1267	58	6	,	,	PUNCT
hjic-1267	58	7	washed	wash	VERB
hjic-1267	58	8	with	with	ADP
hjic-1267	58	9	brine	brine	NOUN
hjic-1267	58	10	,	,	PUNCT
hjic-1267	58	11	dried	dry	VERB
hjic-1267	58	12	over	over	ADP
hjic-1267	58	13	anhydrous	anhydrous	ADJ
hjic-1267	58	14	na2so4	na2so4	NOUN
hjic-1267	58	15	and	and	CCONJ
hjic-1267	58	16	evaporated	evaporate	VERB
hjic-1267	58	17	to	to	PART
hjic-1267	58	18	dryness	dryness	VERB
hjic-1267	58	19	in	in	ADP
hjic-1267	58	20	vacuo	vacuo	PROPN
hjic-1267	58	21	.	.	PUNCT
hjic-1267	59	1	the	the	DET
hjic-1267	59	2	residue	residue	NOUN
hjic-1267	59	3	was	be	AUX
hjic-1267	59	4	purified	purify	VERB
hjic-1267	59	5	by	by	ADP
hjic-1267	59	6	column	column	NOUN
hjic-1267	59	7	chromatography	chromatography	NOUN
hjic-1267	59	8	with	with	ADP
hjic-1267	59	9	a	a	DET
hjic-1267	59	10	gradient	gradient	NOUN
hjic-1267	59	11	of	of	ADP
hjic-1267	59	12	0	0	NUM
hjic-1267	59	13	-	-	SYM
hjic-1267	59	14	30	30	NUM
hjic-1267	59	15	%	%	NOUN
hjic-1267	59	16	ethyl	ethyl	PROPN
hjic-1267	59	17	acetate	acetate	NOUN
hjic-1267	59	18	in	in	ADP
hjic-1267	59	19	hexanes	hexane	NOUN
hjic-1267	59	20	(	(	PUNCT
hjic-1267	59	21	v	v	NOUN
hjic-1267	59	22	/	/	SYM
hjic-1267	59	23	v	v	NOUN
hjic-1267	59	24	)	)	PUNCT
hjic-1267	59	25	to	to	PART
hjic-1267	59	26	produce	produce	VERB
hjic-1267	59	27	9.5	9.5	NUM
hjic-1267	59	28	g	g	NOUN
hjic-1267	59	29	(	(	PUNCT
hjic-1267	59	30	20.1	20.1	NUM
hjic-1267	59	31	mmol	mmol	NOUN
hjic-1267	59	32	)	)	PUNCT
hjic-1267	59	33	with	with	ADP
hjic-1267	59	34	a	a	DET
hjic-1267	59	35	68	68	NUM
hjic-1267	59	36	%	%	NOUN
hjic-1267	59	37	yield	yield	NOUN
hjic-1267	59	38	of	of	ADP
hjic-1267	59	39	compound	compound	NOUN
hjic-1267	59	40	(	(	PUNCT
hjic-1267	59	41	7	7	NUM
hjic-1267	59	42	)	)	PUNCT
hjic-1267	59	43	as	as	ADP
hjic-1267	59	44	a	a	DET
hjic-1267	59	45	white	white	ADJ
hjic-1267	59	46	solid	solid	NOUN
hjic-1267	59	47	.	.	PUNCT
hjic-1267	60	1	https://www.google.com/search?sca_esv=813765718ccf2407&rlz=1c1rxqr_enca1001ca1001&cs=0&q=benzyloxycarbonyl&sa=x&ved=2ahukewinqpfx3oanaxu7tkqehthmiqeqxccnegqibbab&mstk=autexfcfe_lr7lxateue6lqwmounmoxgp4pgdi8y34ia97hrzds1pbob_hm6hhsgduhndbi_xuxehsds8tpkwbv5othu1hjqq5ba_krgitmo3sawmdlsjtzi2gh0himnqemgvtq&csui=3	https://www.google.com/search?sca_esv=813765718ccf2407&rlz=1c1rxqr_enca1001ca1001&cs=0&q=benzyloxycarbonyl&sa=x&ved=2ahukewinqpfx3oanaxu7tkqehthmiqeqxccnegqibbab&mstk=autexfcfe_lr7lxateue6lqwmounmoxgp4pgdi8y34ia97hrzds1pbob_hm6hhsgduhndbi_xuxehsds8tpkwbv5othu1hjqq5ba_krgitmo3sawmdlsjtzi2gh0himnqemgvtq&csui=3	PROPN
hjic-1267	60	2	diastereoselective	diastereoselective	ADJ
hjic-1267	60	3	alkylation	alkylation	NOUN
hjic-1267	60	4	53(2	53(2	NUM
hjic-1267	60	5	)	)	PUNCT
hjic-1267	60	6	pp	pp	ADV
hjic-1267	60	7	.	.	PUNCT
hjic-1267	61	1	49–53	49–53	NUM
hjic-1267	61	2	(	(	PUNCT
hjic-1267	61	3	2025	2025	NUM
hjic-1267	61	4	)	)	PUNCT
hjic-1267	61	5	51	51	NUM
hjic-1267	61	6	3	3	NUM
hjic-1267	61	7	.	.	PUNCT
hjic-1267	61	8	results	result	NOUN
hjic-1267	61	9	and	and	CCONJ
hjic-1267	61	10	discussion	discussion	VERB
hjic-1267	61	11	the	the	DET
hjic-1267	61	12	purpose	purpose	NOUN
hjic-1267	61	13	of	of	ADP
hjic-1267	61	14	this	this	DET
hjic-1267	61	15	article	article	NOUN
hjic-1267	61	16	is	be	AUX
hjic-1267	61	17	to	to	PART
hjic-1267	61	18	report	report	VERB
hjic-1267	61	19	a	a	DET
hjic-1267	61	20	new	new	ADJ
hjic-1267	61	21	procedure	procedure	NOUN
hjic-1267	61	22	regarding	regard	VERB
hjic-1267	61	23	evans	evans	PROPN
hjic-1267	61	24	’	'	PUNCT
hjic-1267	61	25	diastereoselective	diastereoselective	ADJ
hjic-1267	61	26	alkylation	alkylation	NOUN
hjic-1267	61	27	of	of	ADP
hjic-1267	61	28	(	(	PUNCT
hjic-1267	61	29	2r,4r)-4	2r,4r)-4	ADJ
hjic-1267	61	30	-	-	PUNCT
hjic-1267	61	31	methyl-5	methyl-5	NOUN
hjic-1267	61	32	-	-	PUNCT
hjic-1267	61	33	oxo-2	oxo-2	ADV
hjic-1267	61	34	-	-	PUNCT
hjic-1267	61	35	phenyl-1,3	phenyl-1,3	NOUN
hjic-1267	61	36	-	-	PUNCT
hjic-1267	61	37	oxazolidine-3carboxylate	oxazolidine-3carboxylate	NOUN
hjic-1267	61	38	(	(	PUNCT
hjic-1267	61	39	6	6	NUM
hjic-1267	61	40	)	)	PUNCT
hjic-1267	61	41	with	with	ADP
hjic-1267	61	42	2	2	NUM
hjic-1267	61	43	-	-	PUNCT
hjic-1267	61	44	chloromethyl	chloromethyl	NOUN
hjic-1267	61	45	-	-	PUNCT
hjic-1267	61	46	isoindole-1,3	isoindole-1,3	NOUN
hjic-1267	61	47	-	-	PUNCT
hjic-1267	61	48	dione	dione	NOUN
hjic-1267	61	49	(	(	PUNCT
hjic-1267	61	50	3	3	NUM
hjic-1267	61	51	)	)	PUNCT
hjic-1267	61	52	.	.	PUNCT
hjic-1267	62	1	this	this	DET
hjic-1267	62	2	alkylation	alkylation	NOUN
hjic-1267	62	3	is	be	AUX
hjic-1267	62	4	the	the	DET
hjic-1267	62	5	last	last	ADJ
hjic-1267	62	6	stage	stage	NOUN
hjic-1267	62	7	of	of	ADP
hjic-1267	62	8	the	the	DET
hjic-1267	62	9	multistep	multistep	ADJ
hjic-1267	62	10	synthesis	synthesis	NOUN
hjic-1267	62	11	to	to	PART
hjic-1267	62	12	produce	produce	VERB
hjic-1267	62	13	a	a	DET
hjic-1267	62	14	68	68	NUM
hjic-1267	62	15	%	%	NOUN
hjic-1267	62	16	yield	yield	NOUN
hjic-1267	62	17	of	of	ADP
hjic-1267	62	18	compound	compound	NOUN
hjic-1267	62	19	(	(	PUNCT
hjic-1267	62	20	7	7	NUM
hjic-1267	62	21	)	)	PUNCT
hjic-1267	62	22	as	as	ADP
hjic-1267	62	23	a	a	DET
hjic-1267	62	24	white	white	ADJ
hjic-1267	62	25	solid	solid	ADJ
hjic-1267	62	26	as	as	SCONJ
hjic-1267	62	27	shown	show	VERB
hjic-1267	62	28	in	in	ADP
hjic-1267	62	29	figure	figure	NOUN
hjic-1267	62	30	2	2	NUM
hjic-1267	62	31	.	.	PUNCT
hjic-1267	63	1	in	in	ADP
hjic-1267	63	2	summary	summary	NOUN
hjic-1267	63	3	,	,	PUNCT
hjic-1267	63	4	in	in	ADP
hjic-1267	63	5	the	the	DET
hjic-1267	63	6	first	first	ADJ
hjic-1267	63	7	case	case	NOUN
hjic-1267	63	8	,	,	PUNCT
hjic-1267	63	9	a	a	DET
hjic-1267	63	10	starting	start	VERB
hjic-1267	63	11	substance	substance	NOUN
hjic-1267	63	12	that	that	PRON
hjic-1267	63	13	was	be	AUX
hjic-1267	63	14	available	available	ADJ
hjic-1267	63	15	in	in	ADP
hjic-1267	63	16	both	both	CCONJ
hjic-1267	63	17	its	its	PRON
hjic-1267	63	18	enantiomeric	enantiomeric	ADJ
hjic-1267	63	19	form	form	NOUN
hjic-1267	63	20	and	and	CCONJ
hjic-1267	63	21	chiral	chiral	ADJ
hjic-1267	63	22	as	as	ADV
hjic-1267	63	23	well	well	ADV
hjic-1267	63	24	as	as	ADP
hjic-1267	63	25	optically	optically	ADV
hjic-1267	63	26	pure	pure	ADJ
hjic-1267	63	27	was	be	AUX
hjic-1267	63	28	envisioned	envision	VERB
hjic-1267	63	29	.	.	PUNCT
hjic-1267	64	1	the	the	DET
hjic-1267	64	2	cyclization	cyclization	NOUN
hjic-1267	64	3	of	of	ADP
hjic-1267	64	4	cbz	cbz	NOUN
hjic-1267	64	5	-	-	PUNCT
hjic-1267	64	6	protected	protect	VERB
hjic-1267	64	7	(	(	PUNCT
hjic-1267	64	8	d	d	NOUN
hjic-1267	64	9	)	)	PUNCT
hjic-1267	64	10	alanine	alanine	NOUN
hjic-1267	64	11	with	with	ADP
hjic-1267	64	12	benzaldehyde	benzaldehyde	NOUN
hjic-1267	64	13	dimethyl	dimethyl	NOUN
hjic-1267	64	14	acetal	acetal	NOUN
hjic-1267	64	15	yielded	yield	VERB
hjic-1267	64	16	compound	compound	NOUN
hjic-1267	64	17	(	(	PUNCT
hjic-1267	64	18	6	6	NUM
hjic-1267	64	19	)	)	PUNCT
hjic-1267	64	20	after	after	ADP
hjic-1267	64	21	recrystallization	recrystallization	NOUN
hjic-1267	64	22	as	as	ADP
hjic-1267	64	23	a	a	DET
hjic-1267	64	24	single	single	ADJ
hjic-1267	64	25	isomer	isomer	NOUN
hjic-1267	64	26	.	.	PUNCT
hjic-1267	65	1	after	after	ADP
hjic-1267	65	2	the	the	DET
hjic-1267	65	3	lithium	lithium	NOUN
hjic-1267	65	4	enolate	enolate	NOUN
hjic-1267	65	5	of	of	ADP
hjic-1267	65	6	compound	compound	NOUN
hjic-1267	65	7	(	(	PUNCT
hjic-1267	65	8	6	6	NUM
hjic-1267	65	9	)	)	PUNCT
hjic-1267	65	10	was	be	AUX
hjic-1267	65	11	generated	generate	VERB
hjic-1267	65	12	and	and	CCONJ
hjic-1267	65	13	quenched	quench	VERB
hjic-1267	65	14	with	with	ADP
hjic-1267	65	15	compound	compound	NOUN
hjic-1267	65	16	(	(	PUNCT
hjic-1267	65	17	3	3	NUM
hjic-1267	65	18	)	)	PUNCT
hjic-1267	65	19	,	,	PUNCT
hjic-1267	65	20	chirality	chirality	NOUN
hjic-1267	65	21	transfer	transfer	NOUN
hjic-1267	65	22	was	be	AUX
hjic-1267	65	23	accomplished	accomplish	VERB
hjic-1267	65	24	,	,	PUNCT
hjic-1267	65	25	yielding	yield	VERB
hjic-1267	65	26	compound	compound	NOUN
hjic-1267	65	27	(	(	PUNCT
hjic-1267	65	28	7	7	NUM
hjic-1267	65	29	)	)	PUNCT
hjic-1267	65	30	with	with	ADP
hjic-1267	65	31	no	no	DET
hjic-1267	65	32	indication	indication	NOUN
hjic-1267	65	33	of	of	ADP
hjic-1267	65	34	any	any	DET
hjic-1267	65	35	minor	minor	ADJ
hjic-1267	65	36	diastereomers	diastereomer	NOUN
hjic-1267	66	1	[	[	X
hjic-1267	66	2	22	22	NUM
hjic-1267	66	3	]	]	PUNCT
hjic-1267	66	4	.	.	PUNCT
hjic-1267	67	1	the	the	DET
hjic-1267	67	2	identity	identity	NOUN
hjic-1267	67	3	of	of	ADP
hjic-1267	67	4	the	the	DET
hjic-1267	67	5	α	α	NOUN
hjic-1267	67	6	-	-	PUNCT
hjic-1267	67	7	methyl	methyl	ADJ
hjic-1267	67	8	,	,	PUNCT
hjic-1267	67	9	non	non	ADJ
hjic-1267	67	10	-	-	ADJ
hjic-1267	67	11	natural	natural	ADJ
hjic-1267	67	12	amino	amino	NOUN
hjic-1267	67	13	acid	acid	NOUN
hjic-1267	67	14	(	(	PUNCT
hjic-1267	67	15	nnaa	nnaa	NOUN
hjic-1267	67	16	)	)	PUNCT
hjic-1267	67	17	building	building	NOUN
hjic-1267	67	18	block	block	NOUN
hjic-1267	67	19	equipped	equip	VERB
hjic-1267	67	20	with	with	ADP
hjic-1267	67	21	a	a	DET
hjic-1267	67	22	phthalimide	phthalimide	NOUN
hjic-1267	67	23	moiety	moiety	NOUN
hjic-1267	67	24	,	,	PUNCT
hjic-1267	67	25	that	that	ADV
hjic-1267	67	26	is	is	ADV
hjic-1267	67	27	,	,	PUNCT
hjic-1267	67	28	compound	compound	NOUN
hjic-1267	67	29	(	(	PUNCT
hjic-1267	67	30	7	7	NUM
hjic-1267	67	31	)	)	PUNCT
hjic-1267	67	32	,	,	PUNCT
hjic-1267	67	33	was	be	AUX
hjic-1267	67	34	confirmed	confirm	VERB
hjic-1267	67	35	by	by	ADP
hjic-1267	67	36	500mhz	500mhz	NUM
hjic-1267	67	37	nmr	nmr	NOUN
hjic-1267	67	38	and	and	CCONJ
hjic-1267	67	39	hrms	hrm	NOUN
hjic-1267	67	40	spectroscopy	spectroscopy	NOUN
hjic-1267	67	41	.	.	PUNCT
hjic-1267	68	1	the	the	DET
hjic-1267	68	2	experiments	experiment	NOUN
hjic-1267	68	3	were	be	AUX
hjic-1267	68	4	carried	carry	VERB
hjic-1267	68	5	out	out	ADP
hjic-1267	68	6	in	in	ADP
hjic-1267	68	7	dimethyl	dimethyl	PROPN
hjic-1267	68	8	sulfoxided6	sulfoxided6	PROPN
hjic-1267	68	9	(	(	PUNCT
hjic-1267	68	10	dmso	dmso	VERB
hjic-1267	68	11	-	-	NOUN
hjic-1267	68	12	d6	d6	NOUN
hjic-1267	68	13	)	)	PUNCT
hjic-1267	68	14	at	at	ADP
hjic-1267	68	15	100	100	NUM
hjic-1267	68	16	°	°	NOUN
hjic-1267	68	17	c	c	NOUN
hjic-1267	68	18	.	.	PUNCT
hjic-1267	69	1	1h	1h	NUM
hjic-1267	69	2	nmr	nmr	NOUN
hjic-1267	69	3	(	(	PUNCT
hjic-1267	69	4	500	500	NUM
hjic-1267	69	5	mhz	mhz	NOUN
hjic-1267	69	6	,	,	PUNCT
hjic-1267	69	7	dmso	dmso	NOUN
hjic-1267	69	8	-	-	NOUN
hjic-1267	69	9	d6	d6	NOUN
hjic-1267	69	10	,	,	PUNCT
hjic-1267	69	11	100	100	NUM
hjic-1267	69	12	°	°	NOUN
hjic-1267	69	13	c	c	NOUN
hjic-1267	69	14	):	):	PUNCT
hjic-1267	69	15	δ	δ	PROPN
hjic-1267	69	16	8.02	8.02	NUM
hjic-1267	69	17	–	–	PUNCT
hjic-1267	69	18	7.78	7.78	NUM
hjic-1267	69	19	(	(	PUNCT
hjic-1267	69	20	m	m	PROPN
hjic-1267	69	21	,	,	PUNCT
hjic-1267	69	22	4h	4h	NOUN
hjic-1267	69	23	)	)	PUNCT
hjic-1267	69	24	,	,	PUNCT
hjic-1267	69	25	7.52	7.52	NUM
hjic-1267	69	26	–	–	PUNCT
hjic-1267	69	27	7.34	7.34	NUM
hjic-1267	69	28	(	(	PUNCT
hjic-1267	69	29	m	m	PROPN
hjic-1267	69	30	,	,	PUNCT
hjic-1267	69	31	5h	5h	NUM
hjic-1267	69	32	)	)	PUNCT
hjic-1267	69	33	,	,	PUNCT
hjic-1267	69	34	7.34	7.34	NUM
hjic-1267	69	35	–	–	PUNCT
hjic-1267	69	36	6.93	6.93	NUM
hjic-1267	69	37	(	(	PUNCT
hjic-1267	69	38	m	m	PROPN
hjic-1267	69	39	,	,	PUNCT
hjic-1267	69	40	5h	5h	NUM
hjic-1267	69	41	)	)	PUNCT
hjic-1267	69	42	,	,	PUNCT
hjic-1267	69	43	6.40	6.40	NUM
hjic-1267	69	44	(	(	PUNCT
hjic-1267	69	45	s	s	PROPN
hjic-1267	69	46	,	,	PUNCT
hjic-1267	69	47	1h	1h	NUM
hjic-1267	69	48	)	)	PUNCT
hjic-1267	69	49	,	,	PUNCT
hjic-1267	69	50	5.05	5.05	NUM
hjic-1267	69	51	(	(	PUNCT
hjic-1267	69	52	s	s	NOUN
hjic-1267	69	53	,	,	PUNCT
hjic-1267	69	54	2h	2h	NUM
hjic-1267	69	55	)	)	PUNCT
hjic-1267	69	56	,	,	PUNCT
hjic-1267	69	57	4.38	4.38	NUM
hjic-1267	69	58	(	(	PUNCT
hjic-1267	69	59	d	d	PROPN
hjic-1267	69	60	,	,	PUNCT
hjic-1267	69	61	j	j	PROPN
hjic-1267	69	62	=	=	PROPN
hjic-1267	69	63	14.4	14.4	NUM
hjic-1267	69	64	hz	hz	NOUN
hjic-1267	69	65	,	,	PUNCT
hjic-1267	69	66	1h	1h	NUM
hjic-1267	69	67	)	)	PUNCT
hjic-1267	69	68	,	,	PUNCT
hjic-1267	69	69	4.16	4.16	NUM
hjic-1267	69	70	(	(	PUNCT
hjic-1267	69	71	d	d	PROPN
hjic-1267	69	72	,	,	PUNCT
hjic-1267	69	73	j	j	PROPN
hjic-1267	69	74	=	=	PROPN
hjic-1267	69	75	14.4	14.4	NUM
hjic-1267	69	76	hz	hz	NOUN
hjic-1267	69	77	,	,	PUNCT
hjic-1267	69	78	1h	1h	NUM
hjic-1267	69	79	)	)	PUNCT
hjic-1267	69	80	,	,	PUNCT
hjic-1267	69	81	1.87	1.87	NUM
hjic-1267	69	82	(	(	PUNCT
hjic-1267	69	83	s	s	PROPN
hjic-1267	69	84	,	,	PUNCT
hjic-1267	69	85	3h	3h	NUM
hjic-1267	69	86	)	)	PUNCT
hjic-1267	69	87	13c	13c	NOUN
hjic-1267	69	88	nmr	nmr	NOUN
hjic-1267	69	89	(	(	PUNCT
hjic-1267	69	90	126	126	NUM
hjic-1267	69	91	mhz	mhz	NOUN
hjic-1267	69	92	,	,	PUNCT
hjic-1267	69	93	dmso	dmso	NOUN
hjic-1267	69	94	-	-	NOUN
hjic-1267	69	95	d6	d6	NOUN
hjic-1267	69	96	,	,	PUNCT
hjic-1267	69	97	100	100	NUM
hjic-1267	69	98	°	°	NOUN
hjic-1267	69	99	c	c	NOUN
hjic-1267	69	100	)	)	PUNCT
hjic-1267	69	101	δ	δ	PROPN
hjic-1267	69	102	172.05	172.05	NUM
hjic-1267	69	103	,	,	PUNCT
hjic-1267	69	104	168.02	168.02	NUM
hjic-1267	69	105	,	,	PUNCT
hjic-1267	69	106	151.96	151.96	NUM
hjic-1267	69	107	,	,	PUNCT
hjic-1267	69	108	137.40	137.40	NUM
hjic-1267	69	109	,	,	PUNCT
hjic-1267	69	110	136.04	136.04	NUM
hjic-1267	69	111	,	,	PUNCT
hjic-1267	69	112	135.13	135.13	NUM
hjic-1267	69	113	,	,	PUNCT
hjic-1267	69	114	131.90	131.90	NUM
hjic-1267	69	115	,	,	PUNCT
hjic-1267	69	116	130.15	130.15	NUM
hjic-1267	69	117	,	,	PUNCT
hjic-1267	69	118	129.06	129.06	NUM
hjic-1267	69	119	,	,	PUNCT
hjic-1267	69	120	128.64	128.64	NUM
hjic-1267	69	121	,	,	PUNCT
hjic-1267	69	122	128.28	128.28	NUM
hjic-1267	69	123	,	,	PUNCT
hjic-1267	69	124	127.90	127.90	NUM
hjic-1267	69	125	,	,	PUNCT
hjic-1267	69	126	127.22	127.22	NUM
hjic-1267	69	127	,	,	PUNCT
hjic-1267	69	128	123.81	123.81	NUM
hjic-1267	69	129	,	,	PUNCT
hjic-1267	69	130	89.15	89.15	NUM
hjic-1267	69	131	,	,	PUNCT
hjic-1267	69	132	67.44	67.44	NUM
hjic-1267	69	133	,	,	PUNCT
hjic-1267	69	134	61.88	61.88	NUM
hjic-1267	69	135	,	,	PUNCT
hjic-1267	69	136	22.66	22.66	NUM
hjic-1267	69	137	hrms	hrm	NOUN
hjic-1267	69	138	(	(	PUNCT
hjic-1267	69	139	esi	esi	NOUN
hjic-1267	69	140	):	):	PUNCT
hjic-1267	69	141	calcd	calcd	NOUN
hjic-1267	69	142	.	.	PUNCT
hjic-1267	70	1	for	for	ADP
hjic-1267	70	2	c26h20n2o6	c26h20n2o6	PROPN
hjic-1267	71	1	[	[	X
hjic-1267	71	2	m+na]+	m+na]+	NOUN
hjic-1267	71	3	:	:	PUNCT
hjic-1267	71	4	479.1219	479.1219	X
hjic-1267	71	5	.	.	PUNCT
hjic-1267	72	1	the	the	DET
hjic-1267	72	2	peak	peak	NOUN
hjic-1267	72	3	at	at	ADP
hjic-1267	72	4	479.1219	479.1219	PROPN
hjic-1267	72	5	was	be	AUX
hjic-1267	72	6	identified	identify	VERB
hjic-1267	72	7	as	as	ADP
hjic-1267	72	8	shown	show	VERB
hjic-1267	72	9	in	in	ADP
hjic-1267	72	10	figure	figure	NOUN
hjic-1267	72	11	3	3	NUM
hjic-1267	72	12	.	.	PUNCT
hjic-1267	73	1	in	in	ADP
hjic-1267	73	2	summary	summary	NOUN
hjic-1267	73	3	,	,	PUNCT
hjic-1267	73	4	an	an	DET
hjic-1267	73	5	α	α	NOUN
hjic-1267	73	6	-	-	PUNCT
hjic-1267	73	7	methyl	methyl	NOUN
hjic-1267	73	8	nnaa	nnaa	NOUN
hjic-1267	73	9	building	building	NOUN
hjic-1267	73	10	block	block	NOUN
hjic-1267	73	11	equipped	equip	VERB
hjic-1267	73	12	with	with	ADP
hjic-1267	73	13	a	a	DET
hjic-1267	73	14	phthalimide	phthalimide	NOUN
hjic-1267	73	15	group	group	NOUN
hjic-1267	73	16	tail	tail	NOUN
hjic-1267	73	17	,	,	PUNCT
hjic-1267	73	18	namely	namely	ADV
hjic-1267	73	19	compound	compound	NOUN
hjic-1267	73	20	(	(	PUNCT
hjic-1267	73	21	7	7	NUM
hjic-1267	73	22	)	)	PUNCT
hjic-1267	73	23	,	,	PUNCT
hjic-1267	73	24	was	be	AUX
hjic-1267	73	25	prepared	prepare	VERB
hjic-1267	73	26	in	in	ADP
hjic-1267	73	27	good	good	ADJ
hjic-1267	73	28	yield	yield	NOUN
hjic-1267	73	29	in	in	ADP
hjic-1267	73	30	a	a	DET
hjic-1267	73	31	multistep	multistep	ADJ
hjic-1267	73	32	synthesis	synthesis	NOUN
hjic-1267	73	33	by	by	ADP
hjic-1267	73	34	the	the	DET
hjic-1267	73	35	generation	generation	NOUN
hjic-1267	73	36	of	of	ADP
hjic-1267	73	37	the	the	DET
hjic-1267	73	38	lithium	lithium	NOUN
hjic-1267	73	39	enolate	enolate	NOUN
hjic-1267	73	40	for	for	ADP
hjic-1267	73	41	(	(	PUNCT
hjic-1267	73	42	2r,4r)-4	2r,4r)-4	ADJ
hjic-1267	73	43	-	-	PUNCT
hjic-1267	73	44	methyl-5	methyl-5	NOUN
hjic-1267	73	45	-	-	PUNCT
hjic-1267	73	46	oxo-2	oxo-2	ADV
hjic-1267	73	47	-	-	PUNCT
hjic-1267	73	48	phenyl-1,3	phenyl-1,3	NOUN
hjic-1267	73	49	-	-	PUNCT
hjic-1267	73	50	oxazolidine3	oxazolidine3	NOUN
hjic-1267	73	51	-	-	PUNCT
hjic-1267	73	52	carboxylate	carboxylate	NOUN
hjic-1267	73	53	and	and	CCONJ
hjic-1267	73	54	quenching	quenching	NOUN
hjic-1267	73	55	with	with	ADP
hjic-1267	73	56	2	2	NUM
hjic-1267	73	57	-	-	PUNCT
hjic-1267	73	58	chloromethylisoindole-1,3	chloromethylisoindole-1,3	NOUN
hjic-1267	73	59	-	-	PUNCT
hjic-1267	73	60	dione	dione	NOUN
hjic-1267	73	61	,	,	PUNCT
hjic-1267	73	62	to	to	PART
hjic-1267	73	63	achieve	achieve	VERB
hjic-1267	73	64	chirality	chirality	NOUN
hjic-1267	73	65	transfer	transfer	NOUN
hjic-1267	73	66	,	,	PUNCT
hjic-1267	73	67	thereby	thereby	ADV
hjic-1267	73	68	providing	provide	VERB
hjic-1267	73	69	compound	compound	NOUN
hjic-1267	73	70	(	(	PUNCT
hjic-1267	73	71	7	7	NUM
hjic-1267	73	72	)	)	PUNCT
hjic-1267	73	73	with	with	ADP
hjic-1267	73	74	no	no	DET
hjic-1267	73	75	sign	sign	NOUN
hjic-1267	73	76	of	of	ADP
hjic-1267	73	77	any	any	DET
hjic-1267	73	78	minor	minor	ADJ
hjic-1267	73	79	diastereomers	diastereomer	NOUN
hjic-1267	73	80	.	.	PUNCT
hjic-1267	74	1	the	the	DET
hjic-1267	74	2	α	α	NOUN
hjic-1267	74	3	-	-	PUNCT
hjic-1267	74	4	methyl	methyl	NOUN
hjic-1267	74	5	nnaa	nnaa	NOUN
hjic-1267	74	6	building	building	NOUN
hjic-1267	74	7	block	block	NOUN
hjic-1267	74	8	can	can	AUX
hjic-1267	74	9	figure	figure	VERB
hjic-1267	74	10	2	2	NUM
hjic-1267	74	11	:	:	PUNCT
hjic-1267	74	12	asymmetric	asymmetric	ADJ
hjic-1267	74	13	alkylation	alkylation	NOUN
hjic-1267	74	14	between	between	ADP
hjic-1267	74	15	(	(	PUNCT
hjic-1267	74	16	2r,4r)-4	2r,4r)-4	ADJ
hjic-1267	74	17	-	-	PUNCT
hjic-1267	74	18	methyl-5	methyl-5	NOUN
hjic-1267	74	19	-	-	PUNCT
hjic-1267	74	20	oxo-2	oxo-2	ADV
hjic-1267	74	21	-	-	PUNCT
hjic-1267	74	22	phenyl-1,3	phenyl-1,3	NOUN
hjic-1267	74	23	-	-	PUNCT
hjic-1267	74	24	oxazolidine-3	oxazolidine-3	NUM
hjic-1267	74	25	-	-	PUNCT
hjic-1267	74	26	carboxylate	carboxylate	NOUN
hjic-1267	74	27	(	(	PUNCT
hjic-1267	74	28	6	6	NUM
hjic-1267	74	29	)	)	PUNCT
hjic-1267	74	30	and	and	CCONJ
hjic-1267	74	31	2	2	NUM
hjic-1267	74	32	-	-	PUNCT
hjic-1267	74	33	chloromethyl	chloromethyl	NOUN
hjic-1267	74	34	-	-	PUNCT
hjic-1267	74	35	isoindole-1,3	isoindole-1,3	NOUN
hjic-1267	74	36	-	-	PUNCT
hjic-1267	74	37	dione	dione	NOUN
hjic-1267	74	38	(	(	PUNCT
hjic-1267	74	39	3	3	NUM
hjic-1267	74	40	)	)	PUNCT
hjic-1267	74	41	to	to	PART
hjic-1267	74	42	produce	produce	VERB
hjic-1267	74	43	compound	compound	NOUN
hjic-1267	74	44	(	(	PUNCT
hjic-1267	74	45	7	7	NUM
hjic-1267	74	46	)	)	PUNCT
hjic-1267	74	47	(	(	PUNCT
hjic-1267	74	48	a	a	X
hjic-1267	74	49	)	)	PUNCT
hjic-1267	74	50	1h	1h	NUM
hjic-1267	74	51	-	-	PUNCT
hjic-1267	74	52	nmr	nmr	NOUN
hjic-1267	74	53	spectra	spectra	NOUN
hjic-1267	74	54	of	of	ADP
hjic-1267	74	55	compound	compound	NOUN
hjic-1267	74	56	(	(	PUNCT
hjic-1267	74	57	7	7	NUM
hjic-1267	74	58	)	)	PUNCT
hjic-1267	74	59	in	in	ADP
hjic-1267	74	60	dmso	dmso	NOUN
hjic-1267	74	61	-	-	NOUN
hjic-1267	74	62	d6	d6	NOUN
hjic-1267	74	63	at	at	ADP
hjic-1267	74	64	100	100	NUM
hjic-1267	74	65	°	°	NOUN
hjic-1267	74	66	c	c	NOUN
hjic-1267	74	67	(	(	PUNCT
hjic-1267	74	68	b	b	NOUN
hjic-1267	74	69	)	)	PUNCT
hjic-1267	74	70	13c	13c	NOUN
hjic-1267	74	71	-	-	ADJ
hjic-1267	74	72	nmr	nmr	ADJ
hjic-1267	74	73	spectra	spectra	NOUN
hjic-1267	74	74	of	of	ADP
hjic-1267	74	75	compound	compound	NOUN
hjic-1267	74	76	(	(	PUNCT
hjic-1267	74	77	7	7	NUM
hjic-1267	74	78	)	)	PUNCT
hjic-1267	74	79	in	in	ADP
hjic-1267	74	80	dmso	dmso	NOUN
hjic-1267	74	81	-	-	NOUN
hjic-1267	74	82	d6	d6	NOUN
hjic-1267	74	83	at	at	ADP
hjic-1267	74	84	100	100	NUM
hjic-1267	74	85	°	°	NOUN
hjic-1267	74	86	c	c	NOUN
hjic-1267	74	87	(	(	PUNCT
hjic-1267	74	88	c	c	NOUN
hjic-1267	74	89	)	)	PUNCT
hjic-1267	74	90	hrms	hrm	VERB
hjic-1267	74	91	spectra	spectra	NOUN
hjic-1267	74	92	of	of	ADP
hjic-1267	74	93	compound	compound	NOUN
hjic-1267	74	94	(	(	PUNCT
hjic-1267	74	95	7	7	NUM
hjic-1267	74	96	)	)	PUNCT
hjic-1267	74	97	figure	figure	NOUN
hjic-1267	74	98	3	3	NUM
hjic-1267	74	99	:	:	PUNCT
hjic-1267	74	100	characterization	characterization	NOUN
hjic-1267	74	101	of	of	ADP
hjic-1267	74	102	compound	compound	NOUN
hjic-1267	74	103	(	(	PUNCT
hjic-1267	74	104	7	7	NUM
hjic-1267	74	105	)	)	PUNCT
hjic-1267	74	106	bsharat	bsharat	PROPN
hjic-1267	74	107	hungarian	hungarian	PROPN
hjic-1267	74	108	journal	journal	PROPN
hjic-1267	74	109	of	of	ADP
hjic-1267	74	110	industry	industry	NOUN
hjic-1267	74	111	and	and	CCONJ
hjic-1267	74	112	chemistry	chemistry	NOUN
hjic-1267	74	113	52	52	NUM
hjic-1267	74	114	be	be	AUX
hjic-1267	74	115	used	use	VERB
hjic-1267	74	116	in	in	ADP
hjic-1267	74	117	the	the	DET
hjic-1267	74	118	preparation	preparation	NOUN
hjic-1267	74	119	of	of	ADP
hjic-1267	74	120	peptide	peptide	NOUN
hjic-1267	74	121	and	and	CCONJ
hjic-1267	74	122	drug	drug	NOUN
hjic-1267	74	123	discovery	discovery	NOUN
hjic-1267	74	124	processes	process	NOUN
hjic-1267	74	125	[	[	X
hjic-1267	74	126	23]-[30	23]-[30	NUM
hjic-1267	74	127	]	]	X
hjic-1267	74	128	.	.	PUNCT
hjic-1267	75	1	4	4	X
hjic-1267	75	2	.	.	X
hjic-1267	75	3	conclusions	conclusion	NOUN
hjic-1267	75	4	a	a	DET
hjic-1267	75	5	multistep	multistep	ADJ
hjic-1267	75	6	synthesis	synthesis	NOUN
hjic-1267	75	7	pathway	pathway	NOUN
hjic-1267	75	8	was	be	AUX
hjic-1267	75	9	developed	develop	VERB
hjic-1267	75	10	to	to	PART
hjic-1267	75	11	prepare	prepare	VERB
hjic-1267	75	12	an	an	DET
hjic-1267	75	13	α	α	NOUN
hjic-1267	75	14	-	-	PUNCT
hjic-1267	75	15	methyl	methyl	ADJ
hjic-1267	75	16	,	,	PUNCT
hjic-1267	75	17	non	non	ADJ
hjic-1267	75	18	-	-	ADJ
hjic-1267	75	19	natural	natural	ADJ
hjic-1267	75	20	amino	amino	NOUN
hjic-1267	75	21	acid	acid	NOUN
hjic-1267	75	22	building	building	NOUN
hjic-1267	75	23	block	block	NOUN
hjic-1267	75	24	equipped	equip	VERB
hjic-1267	75	25	with	with	ADP
hjic-1267	75	26	a	a	DET
hjic-1267	75	27	phthalimide	phthalimide	NOUN
hjic-1267	75	28	group	group	NOUN
hjic-1267	75	29	tail	tail	NOUN
hjic-1267	75	30	,	,	PUNCT
hjic-1267	75	31	namely	namely	ADV
hjic-1267	75	32	compound	compound	NOUN
hjic-1267	75	33	(	(	PUNCT
hjic-1267	75	34	7	7	NUM
hjic-1267	75	35	)	)	PUNCT
hjic-1267	75	36	,	,	PUNCT
hjic-1267	75	37	in	in	ADP
hjic-1267	75	38	good	good	ADJ
hjic-1267	75	39	yield	yield	NOUN
hjic-1267	75	40	with	with	ADP
hjic-1267	75	41	no	no	DET
hjic-1267	75	42	sign	sign	NOUN
hjic-1267	75	43	of	of	ADP
hjic-1267	75	44	any	any	DET
hjic-1267	75	45	minor	minor	ADJ
hjic-1267	75	46	diastereomers	diastereomer	NOUN
hjic-1267	75	47	.	.	PUNCT
hjic-1267	76	1	the	the	DET
hjic-1267	76	2	power	power	NOUN
hjic-1267	76	3	of	of	ADP
hjic-1267	76	4	chiral	chiral	ADJ
hjic-1267	76	5	auxiliaries	auxiliary	NOUN
hjic-1267	76	6	in	in	ADP
hjic-1267	76	7	asymmetric	asymmetric	ADJ
hjic-1267	76	8	synthesis	synthesis	NOUN
hjic-1267	76	9	was	be	AUX
hjic-1267	76	10	demonstrated	demonstrate	VERB
hjic-1267	76	11	using	use	VERB
hjic-1267	76	12	the	the	DET
hjic-1267	76	13	highly	highly	ADV
hjic-1267	76	14	utilized	utilize	VERB
hjic-1267	76	15	and	and	CCONJ
hjic-1267	76	16	well	well	ADV
hjic-1267	76	17	-	-	PUNCT
hjic-1267	76	18	understood	understand	VERB
hjic-1267	76	19	evans	evans	PROPN
hjic-1267	76	20	oxazolidinone	oxazolidinone	NOUN
hjic-1267	76	21	system	system	NOUN
hjic-1267	76	22	.	.	PUNCT
hjic-1267	77	1	this	this	DET
hjic-1267	77	2	α	α	NOUN
hjic-1267	77	3	-	-	PUNCT
hjic-1267	77	4	methyl	methyl	ADJ
hjic-1267	77	5	,	,	PUNCT
hjic-1267	77	6	non	non	ADJ
hjic-1267	77	7	-	-	ADJ
hjic-1267	77	8	natural	natural	ADJ
hjic-1267	77	9	amino	amino	NOUN
hjic-1267	77	10	acid	acid	NOUN
hjic-1267	77	11	building	building	NOUN
hjic-1267	77	12	block	block	NOUN
hjic-1267	77	13	could	could	AUX
hjic-1267	77	14	be	be	AUX
hjic-1267	77	15	used	use	VERB
hjic-1267	77	16	in	in	ADP
hjic-1267	77	17	the	the	DET
hjic-1267	77	18	preparation	preparation	NOUN
hjic-1267	77	19	of	of	ADP
hjic-1267	77	20	peptide	peptide	NOUN
hjic-1267	77	21	and	and	CCONJ
hjic-1267	77	22	drug	drug	NOUN
hjic-1267	77	23	discovery	discovery	NOUN
hjic-1267	77	24	processes	process	NOUN
hjic-1267	77	25	in	in	ADP
hjic-1267	77	26	the	the	DET
hjic-1267	77	27	future	future	NOUN
hjic-1267	77	28	.	.	PUNCT
hjic-1267	78	1	symbols	symbol	NOUN
hjic-1267	78	2	nnaa	nnaa	PROPN
hjic-1267	78	3	:	:	PUNCT
hjic-1267	78	4	non	non	ADJ
hjic-1267	78	5	-	-	ADJ
hjic-1267	78	6	natural	natural	ADJ
hjic-1267	78	7	amino	amino	NOUN
hjic-1267	78	8	acid	acid	NOUN
hjic-1267	78	9	1h	1h	NUM
hjic-1267	78	10	nmr	nmr	NOUN
hjic-1267	78	11	:	:	PUNCT
hjic-1267	78	12	proton	proton	NOUN
hjic-1267	78	13	nuclear	nuclear	ADJ
hjic-1267	78	14	magnetic	magnetic	ADJ
hjic-1267	78	15	resonance	resonance	NOUN
hjic-1267	78	16	13c	13c	NOUN
hjic-1267	78	17	nmr	nmr	NOUN
hjic-1267	78	18	:	:	PUNCT
hjic-1267	78	19	carbon-13	carbon-13	PROPN
hjic-1267	78	20	nuclear	nuclear	ADJ
hjic-1267	78	21	magnetic	magnetic	ADJ
hjic-1267	78	22	resonance	resonance	NOUN
hjic-1267	78	23	nmr	nmr	NOUN
hjic-1267	78	24	:	:	PUNCT
hjic-1267	78	25	nuclear	nuclear	ADJ
hjic-1267	78	26	magnetic	magnetic	ADJ
hjic-1267	78	27	resonance	resonance	NOUN
hjic-1267	78	28	dcm	dcm	PROPN
hjic-1267	78	29	:	:	PUNCT
hjic-1267	78	30	dichloromethane	dichloromethane	NOUN
hjic-1267	78	31	cbz	cbz	NOUN
hjic-1267	78	32	:	:	PUNCT
hjic-1267	78	33	benzyloxycarbonyl	benzyloxycarbonyl	NOUN
hjic-1267	78	34	socl2	socl2	NOUN
hjic-1267	78	35	:	:	PUNCT
hjic-1267	78	36	thionyl	thionyl	ADJ
hjic-1267	78	37	chloride	chloride	NOUN
hjic-1267	78	38	thf	thf	NOUN
hjic-1267	78	39	:	:	PUNCT
hjic-1267	78	40	tetrahydrofuran	tetrahydrofuran	NOUN
hjic-1267	78	41	nahco3	nahco3	NOUN
hjic-1267	78	42	:	:	PUNCT
hjic-1267	78	43	sodium	sodium	NOUN
hjic-1267	78	44	bicarbonate	bicarbonate	NOUN
hjic-1267	78	45	na2so4	na2so4	NOUN
hjic-1267	78	46	:	:	PUNCT
hjic-1267	78	47	sodium	sodium	NOUN
hjic-1267	78	48	sulphate	sulphate	NOUN
hjic-1267	78	49	nmp	nmp	NOUN
hjic-1267	78	50	:	:	PUNCT
hjic-1267	78	51	n	n	CCONJ
hjic-1267	78	52	-	-	PUNCT
hjic-1267	78	53	methyl-2	methyl-2	NOUN
hjic-1267	78	54	-	-	PUNCT
hjic-1267	78	55	pyrrolidone	pyrrolidone	ADJ
hjic-1267	78	56	lihmds	lihmds	NOUN
hjic-1267	78	57	:	:	PUNCT
hjic-1267	78	58	lithium	lithium	NOUN
hjic-1267	78	59	bis(trimethylsilyl)amide	bis(trimethylsilyl)amide	NUM
hjic-1267	78	60	nh4cl	nh4cl	NUM
hjic-1267	78	61	:	:	PUNCT
hjic-1267	78	62	ammonium	ammonium	NOUN
hjic-1267	78	63	chloride	chloride	NOUN
hjic-1267	78	64	dmso	dmso	NOUN
hjic-1267	78	65	-	-	NOUN
hjic-1267	78	66	d6	d6	NOUN
hjic-1267	78	67	:	:	PUNCT
hjic-1267	78	68	dimethyl	dimethyl	NOUN
hjic-1267	78	69	sulfoxide	sulfoxide	NOUN
hjic-1267	78	70	-	-	PUNCT
hjic-1267	78	71	d6	d6	NOUN
hjic-1267	78	72	acknowledgement	acknowledgement	NOUN
hjic-1267	78	73	the	the	DET
hjic-1267	78	74	research	research	NOUN
hjic-1267	78	75	was	be	AUX
hjic-1267	78	76	supported	support	VERB
hjic-1267	78	77	by	by	ADP
hjic-1267	78	78	an	an	DET
hjic-1267	78	79	-	-	PUNCT
hjic-1267	78	80	najah	najah	ADJ
hjic-1267	78	81	national	national	ADJ
hjic-1267	78	82	university	university	NOUN
hjic-1267	78	83	.	.	PUNCT
hjic-1267	79	1	references	reference	NOUN
hjic-1267	79	2	[	[	X
hjic-1267	79	3	1	1	NUM
hjic-1267	79	4	]	]	PUNCT
hjic-1267	79	5	nicolaou	nicolaou	NOUN
hjic-1267	79	6	,	,	PUNCT
hjic-1267	79	7	k.c	k.c	PROPN
hjic-1267	79	8	.	.	PROPN
hjic-1267	79	9	;	;	PUNCT
hjic-1267	79	10	sorensen	sorensen	PROPN
hjic-1267	79	11	,	,	PUNCT
hjic-1267	79	12	e.j	e.j	PROPN
hjic-1267	79	13	.	.	PROPN
hjic-1267	79	14	;	;	PUNCT
hjic-1267	79	15	winssinger	winssinger	ADJ
hjic-1267	79	16	,	,	PUNCT
hjic-1267	79	17	n.	n.	NOUN
hjic-1267	79	18	:	:	PUNCT
hjic-1267	79	19	the	the	DET
hjic-1267	79	20	art	art	NOUN
hjic-1267	79	21	and	and	CCONJ
hjic-1267	79	22	science	science	NOUN
hjic-1267	79	23	of	of	ADP
hjic-1267	79	24	organic	organic	ADJ
hjic-1267	79	25	and	and	CCONJ
hjic-1267	79	26	natural	natural	ADJ
hjic-1267	79	27	products	product	NOUN
hjic-1267	79	28	synthesis	synthesis	NOUN
hjic-1267	79	29	,	,	PUNCT
hjic-1267	79	30	j.	j.	PROPN
hjic-1267	79	31	chem	chem	PROPN
hjic-1267	79	32	.	.	PUNCT
hjic-1267	80	1	educ	educ	PROPN
hjic-1267	80	2	.	.	PUNCT
hjic-1267	80	3	,	,	PUNCT
hjic-1267	80	4	1998	1998	NUM
hjic-1267	80	5	,	,	PUNCT
hjic-1267	80	6	75(10	75(10	NUM
hjic-1267	80	7	)	)	PUNCT
hjic-1267	80	8	,	,	PUNCT
hjic-1267	80	9	1226	1226	NUM
hjic-1267	80	10	–	–	PUNCT
hjic-1267	80	11	1258	1258	NUM
hjic-1267	80	12	,	,	PUNCT
hjic-1267	80	13	doi	doi	NOUN
hjic-1267	80	14	:	:	PUNCT
hjic-1267	80	15	10.1021	10.1021	NUM
hjic-1267	80	16	/	/	SYM
hjic-1267	80	17	ed075p1225	ed075p1225	X
hjic-1267	81	1	[	[	X
hjic-1267	81	2	2	2	NUM
hjic-1267	81	3	]	]	PUNCT
hjic-1267	81	4	rouh	rouh	NOUN
hjic-1267	81	5	,	,	PUNCT
hjic-1267	81	6	a.m.	a.m.	ADV
hjic-1267	81	7	:	:	PUNCT
hjic-1267	81	8	chiral	chiral	ADJ
hjic-1267	81	9	chemistry	chemistry	NOUN
hjic-1267	81	10	,	,	PUNCT
hjic-1267	81	11	chem	chem	NOUN
hjic-1267	81	12	.	.	PUNCT
hjic-1267	82	1	eng	eng	PROPN
hjic-1267	82	2	.	.	PUNCT
hjic-1267	82	3	news	news	PROPN
hjic-1267	82	4	,	,	PUNCT
hjic-1267	82	5	2004	2004	NUM
hjic-1267	82	6	,	,	PUNCT
hjic-1267	82	7	82(24	82(24	NUM
hjic-1267	82	8	)	)	PUNCT
hjic-1267	82	9	,	,	PUNCT
hjic-1267	82	10	47–62	47–62	NUM
hjic-1267	82	11	,	,	PUNCT
hjic-1267	82	12	doi	doi	NOUN
hjic-1267	82	13	:	:	PUNCT
hjic-1267	82	14	10.1021	10.1021	NUM
hjic-1267	82	15	/	/	SYM
hjic-1267	82	16	cen	cen	NOUN
hjic-1267	82	17	-	-	PUNCT
hjic-1267	82	18	v082n024.p047	v082n024.p047	PROPN
hjic-1267	83	1	[	[	X
hjic-1267	83	2	3	3	NUM
hjic-1267	83	3	]	]	PUNCT
hjic-1267	83	4	roos	roo	NOUN
hjic-1267	83	5	,	,	PUNCT
hjic-1267	83	6	g.	g.	NOUN
hjic-1267	83	7	:	:	PUNCT
hjic-1267	83	8	compendium	compendium	NOUN
hjic-1267	83	9	of	of	ADP
hjic-1267	83	10	chiral	chiral	ADJ
hjic-1267	83	11	auxiliary	auxiliary	ADJ
hjic-1267	83	12	applications	application	NOUN
hjic-1267	83	13	(	(	PUNCT
hjic-1267	83	14	academic	academic	ADJ
hjic-1267	83	15	press	press	NOUN
hjic-1267	83	16	:	:	PUNCT
hjic-1267	83	17	new	new	PROPN
hjic-1267	83	18	york	york	PROPN
hjic-1267	83	19	,	,	PUNCT
hjic-1267	83	20	usa	usa	PROPN
hjic-1267	83	21	)	)	PUNCT
hjic-1267	83	22	,	,	PUNCT
hjic-1267	83	23	2002	2002	NUM
hjic-1267	83	24	,	,	PUNCT
hjic-1267	83	25	isbn	isbn	ADJ
hjic-1267	83	26	:	:	PUNCT
hjic-1267	83	27	9780125953429	9780125953429	NUM
hjic-1267	84	1	[	[	X
hjic-1267	84	2	4	4	NUM
hjic-1267	84	3	]	]	X
hjic-1267	84	4	ager	ager	NOUN
hjic-1267	84	5	,	,	PUNCT
hjic-1267	84	6	d.j	d.j	PROPN
hjic-1267	84	7	.	.	PROPN
hjic-1267	84	8	;	;	PUNCT
hjic-1267	84	9	prakash	prakash	PROPN
hjic-1267	84	10	,	,	PUNCT
hjic-1267	84	11	i.	i.	PROPN
hjic-1267	84	12	;	;	PUNCT
hjic-1267	84	13	schaad	schaad	PROPN
hjic-1267	84	14	,	,	PUNCT
hjic-1267	84	15	d.r	d.r	PROPN
hjic-1267	84	16	.	.	PROPN
hjic-1267	84	17	:	:	PUNCT
hjic-1267	84	18	chiral	chiral	ADJ
hjic-1267	84	19	oxazolidinones	oxazolidinone	NOUN
hjic-1267	84	20	in	in	ADP
hjic-1267	84	21	asymmetric	asymmetric	ADJ
hjic-1267	84	22	synthesis	synthesis	NOUN
hjic-1267	84	23	,	,	PUNCT
hjic-1267	84	24	aldrichim	aldrichim	ADJ
hjic-1267	84	25	.	.	PUNCT
hjic-1267	85	1	acta	acta	PROPN
hjic-1267	85	2	,	,	PUNCT
hjic-1267	85	3	1997	1997	NUM
hjic-1267	85	4	,	,	PUNCT
hjic-1267	85	5	30(1	30(1	NUM
hjic-1267	85	6	)	)	PUNCT
hjic-1267	85	7	,	,	PUNCT
hjic-1267	85	8	3–11	3–11	PROPN
hjic-1267	85	9	[	[	X
hjic-1267	85	10	5	5	NUM
hjic-1267	85	11	]	]	PUNCT
hjic-1267	85	12	zappia	zappia	PROPN
hjic-1267	85	13	,	,	PUNCT
hjic-1267	85	14	g.	g.	PROPN
hjic-1267	85	15	;	;	PUNCT
hjic-1267	85	16	gacs	gac	NOUN
hjic-1267	85	17	-	-	PUNCT
hjic-1267	85	18	baitz	baitz	PROPN
hjic-1267	85	19	,	,	PUNCT
hjic-1267	85	20	e.	e.	PROPN
hjic-1267	85	21	;	;	PUNCT
hjic-1267	85	22	delle	delle	PROPN
hjic-1267	85	23	monache	monache	PROPN
hjic-1267	85	24	,	,	PUNCT
hjic-1267	85	25	g.	g.	PROPN
hjic-1267	85	26	;	;	PUNCT
hjic-1267	85	27	misiti	misiti	PROPN
hjic-1267	85	28	,	,	PUNCT
hjic-1267	85	29	d.	d.	PROPN
hjic-1267	85	30	;	;	PUNCT
hjic-1267	85	31	nevola	nevola	PROPN
hjic-1267	85	32	,	,	PUNCT
hjic-1267	85	33	l.	l.	PROPN
hjic-1267	85	34	;	;	PUNCT
hjic-1267	85	35	botta	botta	PROPN
hjic-1267	85	36	,	,	PUNCT
hjic-1267	85	37	b.	b.	PROPN
hjic-1267	85	38	:	:	PUNCT
hjic-1267	85	39	oxazolidin-2	oxazolidin-2	NUM
hjic-1267	85	40	-	-	SYM
hjic-1267	85	41	one	one	NUM
hjic-1267	85	42	ring	ring	NOUN
hjic-1267	85	43	,	,	PUNCT
hjic-1267	85	44	a	a	DET
hjic-1267	85	45	popular	popular	ADJ
hjic-1267	85	46	framework	framework	NOUN
hjic-1267	85	47	in	in	ADP
hjic-1267	85	48	synthetic	synthetic	ADJ
hjic-1267	85	49	organic	organic	ADJ
hjic-1267	85	50	chemistry	chemistry	NOUN
hjic-1267	85	51	:	:	PUNCT
hjic-1267	85	52	part	part	NOUN
hjic-1267	85	53	1	1	NUM
hjic-1267	85	54	.	.	PUNCT
hjic-1267	86	1	the	the	DET
hjic-1267	86	2	construction	construction	NOUN
hjic-1267	86	3	of	of	ADP
hjic-1267	86	4	the	the	DET
hjic-1267	86	5	oxazolidin-2	oxazolidin-2	NUM
hjic-1267	86	6	-	-	PUNCT
hjic-1267	86	7	one	one	NUM
hjic-1267	86	8	ring	ring	NOUN
hjic-1267	86	9	,	,	PUNCT
hjic-1267	86	10	curr	curr	PROPN
hjic-1267	86	11	.	.	PUNCT
hjic-1267	86	12	org	org	PROPN
hjic-1267	86	13	.	.	PUNCT
hjic-1267	86	14	synth	synth	PROPN
hjic-1267	86	15	.	.	PROPN
hjic-1267	86	16	,	,	PUNCT
hjic-1267	86	17	2007	2007	NUM
hjic-1267	86	18	,	,	PUNCT
hjic-1267	86	19	4(1	4(1	NUM
hjic-1267	86	20	)	)	PUNCT
hjic-1267	86	21	,	,	PUNCT
hjic-1267	86	22	81–135	81–135	NUM
hjic-1267	86	23	,	,	PUNCT
hjic-1267	86	24	doi	doi	NOUN
hjic-1267	86	25	:	:	PUNCT
hjic-1267	86	26	10.2174/157017907779981552	10.2174/157017907779981552	NUM
hjic-1267	86	27	[	[	X
hjic-1267	86	28	6	6	NUM
hjic-1267	86	29	]	]	PUNCT
hjic-1267	86	30	corey	corey	PROPN
hjic-1267	86	31	,	,	PUNCT
hjic-1267	86	32	e.j	e.j	PROPN
hjic-1267	86	33	.	.	PROPN
hjic-1267	86	34	;	;	PUNCT
hjic-1267	86	35	ensley	ensley	PROPN
hjic-1267	86	36	,	,	PUNCT
hjic-1267	86	37	h.e	h.e	PROPN
hjic-1267	86	38	.	.	PROPN
hjic-1267	86	39	:	:	PUNCT
hjic-1267	86	40	preparation	preparation	NOUN
hjic-1267	86	41	of	of	ADP
hjic-1267	86	42	an	an	DET
hjic-1267	86	43	optically	optically	ADV
hjic-1267	86	44	active	active	ADJ
hjic-1267	86	45	prostaglandin	prostaglandin	NOUN
hjic-1267	86	46	intermediate	intermediate	ADJ
hjic-1267	86	47	via	via	ADP
hjic-1267	86	48	asymmetric	asymmetric	ADJ
hjic-1267	86	49	induction	induction	NOUN
hjic-1267	86	50	,	,	PUNCT
hjic-1267	86	51	j.	j.	PROPN
hjic-1267	86	52	am	am	PROPN
hjic-1267	86	53	.	.	PUNCT
hjic-1267	87	1	chem	chem	NOUN
hjic-1267	87	2	.	.	PUNCT
hjic-1267	88	1	soc	soc	PROPN
hjic-1267	88	2	.	.	PUNCT
hjic-1267	88	3	,	,	PUNCT
hjic-1267	88	4	1975	1975	NUM
hjic-1267	88	5	,	,	PUNCT
hjic-1267	88	6	97(23	97(23	NOUN
hjic-1267	88	7	)	)	PUNCT
hjic-1267	88	8	,	,	PUNCT
hjic-1267	88	9	6908–6909	6908–6909	NUM
hjic-1267	88	10	,	,	PUNCT
hjic-1267	88	11	doi	doi	NOUN
hjic-1267	88	12	:	:	PUNCT
hjic-1267	88	13	10.1021	10.1021	NUM
hjic-1267	88	14	/	/	SYM
hjic-1267	88	15	ja00856a074	ja00856a074	PROPN
hjic-1267	89	1	[	[	X
hjic-1267	89	2	7	7	NUM
hjic-1267	89	3	]	]	X
hjic-1267	89	4	trost	trost	PROPN
hjic-1267	89	5	,	,	PUNCT
hjic-1267	89	6	b.m	b.m	PROPN
hjic-1267	89	7	.	.	PROPN
hjic-1267	89	8	;	;	PUNCT
hjic-1267	89	9	o’krongly	o’krongly	ADV
hjic-1267	89	10	,	,	PUNCT
hjic-1267	89	11	d.	d.	PROPN
hjic-1267	89	12	;	;	PUNCT
hjic-1267	89	13	belletire	belletire	PROPN
hjic-1267	89	14	,	,	PUNCT
hjic-1267	89	15	j.l	j.l	PROPN
hjic-1267	89	16	.	.	PROPN
hjic-1267	89	17	:	:	PUNCT
hjic-1267	89	18	a	a	DET
hjic-1267	89	19	model	model	NOUN
hjic-1267	89	20	for	for	ADP
hjic-1267	89	21	asymmetric	asymmetric	ADJ
hjic-1267	89	22	induction	induction	NOUN
hjic-1267	89	23	in	in	ADP
hjic-1267	89	24	the	the	DET
hjic-1267	89	25	diels	diel	NOUN
hjic-1267	89	26	-	-	PUNCT
hjic-1267	89	27	alder	alder	NOUN
hjic-1267	89	28	reaction	reaction	NOUN
hjic-1267	89	29	,	,	PUNCT
hjic-1267	89	30	j.	j.	PROPN
hjic-1267	89	31	am	am	PROPN
hjic-1267	89	32	.	.	PUNCT
hjic-1267	90	1	chem	chem	NOUN
hjic-1267	90	2	.	.	PUNCT
hjic-1267	91	1	soc	soc	PROPN
hjic-1267	91	2	.	.	PUNCT
hjic-1267	91	3	,	,	PUNCT
hjic-1267	91	4	1980	1980	NUM
hjic-1267	91	5	,	,	PUNCT
hjic-1267	91	6	102(25	102(25	PROPN
hjic-1267	91	7	)	)	PUNCT
hjic-1267	91	8	,	,	PUNCT
hjic-1267	91	9	7595	7595	NUM
hjic-1267	91	10	–	–	PUNCT
hjic-1267	91	11	7596	7596	NUM
hjic-1267	91	12	,	,	PUNCT
hjic-1267	91	13	doi	doi	NOUN
hjic-1267	91	14	:	:	PUNCT
hjic-1267	91	15	10.1021	10.1021	NUM
hjic-1267	91	16	/	/	SYM
hjic-1267	91	17	ja00545a049	ja00545a049	NOUN
hjic-1267	92	1	[	[	X
hjic-1267	92	2	8	8	NUM
hjic-1267	92	3	]	]	X
hjic-1267	92	4	whitesell	whitesell	PROPN
hjic-1267	92	5	,	,	PUNCT
hjic-1267	92	6	j.k	j.k	PROPN
hjic-1267	92	7	.	.	PROPN
hjic-1267	92	8	;	;	PUNCT
hjic-1267	92	9	chen	chen	PROPN
hjic-1267	92	10	,	,	PUNCT
hjic-1267	92	11	h.h	h.h	PROPN
hjic-1267	92	12	.	.	PROPN
hjic-1267	92	13	;	;	PUNCT
hjic-1267	92	14	lawrence	lawrence	PROPN
hjic-1267	92	15	,	,	PUNCT
hjic-1267	92	16	r.m	r.m	PROPN
hjic-1267	92	17	.	.	PROPN
hjic-1267	92	18	:	:	PUNCT
hjic-1267	92	19	trans-2	trans-2	NUM
hjic-1267	92	20	-	-	PUNCT
hjic-1267	92	21	phenylcyclohexanol	phenylcyclohexanol	NOUN
hjic-1267	92	22	.	.	PUNCT
hjic-1267	93	1	a	a	DET
hjic-1267	93	2	powerful	powerful	ADJ
hjic-1267	93	3	and	and	CCONJ
hjic-1267	93	4	readily	readily	ADV
hjic-1267	93	5	available	available	ADJ
hjic-1267	93	6	chiral	chiral	ADJ
hjic-1267	93	7	auxiliary	auxiliary	NOUN
hjic-1267	93	8	,	,	PUNCT
hjic-1267	93	9	j.	j.	PROPN
hjic-1267	93	10	org	org	PROPN
hjic-1267	93	11	.	.	PUNCT
hjic-1267	93	12	chem	chem	PROPN
hjic-1267	93	13	.	.	PUNCT
hjic-1267	93	14	,	,	PUNCT
hjic-1267	93	15	1985	1985	NUM
hjic-1267	93	16	,	,	PUNCT
hjic-1267	93	17	50(23	50(23	PROPN
hjic-1267	93	18	)	)	PUNCT
hjic-1267	93	19	,	,	PUNCT
hjic-1267	93	20	4663–4664	4663–4664	NUM
hjic-1267	93	21	,	,	PUNCT
hjic-1267	93	22	doi	doi	NOUN
hjic-1267	93	23	:	:	PUNCT
hjic-1267	93	24	10.1021	10.1021	NUM
hjic-1267	93	25	/	/	SYM
hjic-1267	93	26	jo00223a055	jo00223a055	NOUN
hjic-1267	94	1	[	[	X
hjic-1267	94	2	9	9	NUM
hjic-1267	94	3	]	]	X
hjic-1267	94	4	newman	newman	PROPN
hjic-1267	94	5	,	,	PUNCT
hjic-1267	94	6	m.s	m.s	PROPN
hjic-1267	94	7	.	.	PROPN
hjic-1267	94	8	;	;	PUNCT
hjic-1267	94	9	kutner	kutner	PROPN
hjic-1267	94	10	,	,	PUNCT
hjic-1267	94	11	a.	a.	NOUN
hjic-1267	94	12	:	:	PUNCT
hjic-1267	94	13	new	new	ADJ
hjic-1267	94	14	reactions	reaction	NOUN
hjic-1267	94	15	involving	involve	VERB
hjic-1267	94	16	alkaline	alkaline	ADJ
hjic-1267	94	17	treatment	treatment	NOUN
hjic-1267	94	18	of	of	ADP
hjic-1267	94	19	3	3	NUM
hjic-1267	94	20	-	-	PUNCT
hjic-1267	94	21	nitroso-2oxazolidones	nitroso-2oxazolidone	NOUN
hjic-1267	94	22	,	,	PUNCT
hjic-1267	94	23	j.	j.	PROPN
hjic-1267	94	24	am	am	PROPN
hjic-1267	94	25	.	.	PUNCT
hjic-1267	95	1	chem	chem	NOUN
hjic-1267	95	2	.	.	PUNCT
hjic-1267	96	1	soc	soc	PROPN
hjic-1267	96	2	.	.	PUNCT
hjic-1267	96	3	,	,	PUNCT
hjic-1267	96	4	1951	1951	NUM
hjic-1267	96	5	,	,	PUNCT
hjic-1267	96	6	73(9	73(9	NUM
hjic-1267	96	7	)	)	PUNCT
hjic-1267	96	8	,	,	PUNCT
hjic-1267	96	9	4199–4204	4199–4204	NUM
hjic-1267	96	10	,	,	PUNCT
hjic-1267	96	11	doi	doi	NOUN
hjic-1267	96	12	:	:	PUNCT
hjic-1267	96	13	10.1021	10.1021	NUM
hjic-1267	96	14	/	/	SYM
hjic-1267	96	15	ja01153a047	ja01153a047	PROPN
hjic-1267	97	1	[	[	X
hjic-1267	97	2	10	10	NUM
hjic-1267	97	3	]	]	X
hjic-1267	97	4	crowther	crowther	PROPN
hjic-1267	97	5	,	,	PUNCT
hjic-1267	97	6	h.l	h.l	PROPN
hjic-1267	97	7	.	.	PROPN
hjic-1267	97	8	;	;	PUNCT
hjic-1267	97	9	mccombie	mccombie	PROPN
hjic-1267	97	10	,	,	PUNCT
hjic-1267	97	11	h.	h.	PROPN
hjic-1267	97	12	:	:	PUNCT
hjic-1267	97	13	v.-the	v.-the	DET
hjic-1267	97	14	formation	formation	NOUN
hjic-1267	97	15	of	of	ADP
hjic-1267	97	16	tetrahydro	tetrahydro	NOUN
hjic-1267	97	17	-	-	PUNCT
hjic-1267	97	18	oxazoles	oxazole	NOUN
hjic-1267	97	19	from	from	ADP
hjic-1267	97	20	α	α	ADV
hjic-1267	97	21	-	-	PUNCT
hjic-1267	97	22	hydroxy	hydroxy	VERB
hjic-1267	97	23	-	-	PUNCT
hjic-1267	97	24	β	β	NOUN
hjic-1267	97	25	-	-	PUNCT
hjic-1267	97	26	anilinoαβ	anilinoαβ	NOUN
hjic-1267	97	27	-	-	PUNCT
hjic-1267	97	28	diphenylethane	diphenylethane	NOUN
hjic-1267	97	29	and	and	CCONJ
hjic-1267	97	30	its	its	PRON
hjic-1267	97	31	homologues	homologue	NOUN
hjic-1267	97	32	,	,	PUNCT
hjic-1267	97	33	j.	j.	PROPN
hjic-1267	97	34	chem	chem	PROPN
hjic-1267	97	35	.	.	PUNCT
hjic-1267	97	36	soc	soc	PROPN
hjic-1267	97	37	.	.	PROPN
hjic-1267	97	38	,	,	PUNCT
hjic-1267	97	39	trans	trans	PROPN
hjic-1267	97	40	.	.	PROPN
hjic-1267	97	41	,	,	PUNCT
hjic-1267	97	42	1913	1913	NUM
hjic-1267	97	43	,	,	PUNCT
hjic-1267	97	44	103	103	NUM
hjic-1267	97	45	,	,	PUNCT
hjic-1267	97	46	27–31	27–31	NUM
hjic-1267	97	47	,	,	PUNCT
hjic-1267	97	48	doi	doi	NOUN
hjic-1267	97	49	:	:	PUNCT
hjic-1267	97	50	10.1039	10.1039	NUM
hjic-1267	97	51	/	/	SYM
hjic-1267	97	52	ct9130300027	ct9130300027	NOUN
hjic-1267	97	53	[	[	X
hjic-1267	97	54	11	11	NUM
hjic-1267	97	55	]	]	PUNCT
hjic-1267	97	56	sibi	sibi	X
hjic-1267	97	57	,	,	PUNCT
hjic-1267	97	58	m.p	m.p	PROPN
hjic-1267	97	59	.	.	PROPN
hjic-1267	97	60	;	;	PUNCT
hjic-1267	97	61	rutherford	rutherford	PROPN
hjic-1267	97	62	,	,	PUNCT
hjic-1267	97	63	d.	d.	PROPN
hjic-1267	97	64	;	;	PUNCT
hjic-1267	97	65	sharma	sharma	PROPN
hjic-1267	97	66	,	,	PUNCT
hjic-1267	97	67	r.	r.	PROPN
hjic-1267	97	68	:	:	PUNCT
hjic-1267	97	69	a	a	DET
hjic-1267	97	70	new	new	ADJ
hjic-1267	97	71	electrophilic	electrophilic	ADJ
hjic-1267	97	72	alaninol	alaninol	NOUN
hjic-1267	97	73	synthon	synthon	ADJ
hjic-1267	97	74	.	.	PUNCT
hjic-1267	98	1	a	a	DET
hjic-1267	98	2	general	general	ADJ
hjic-1267	98	3	route	route	NOUN
hjic-1267	98	4	to	to	ADP
hjic-1267	98	5	oxazolidinones	oxazolidinone	NOUN
hjic-1267	98	6	of	of	ADP
hjic-1267	98	7	d	d	NOUN
hjic-1267	98	8	or	or	CCONJ
hjic-1267	98	9	(	(	PUNCT
hjic-1267	98	10	r)-2	r)-2	NOUN
hjic-1267	98	11	-	-	PUNCT
hjic-1267	98	12	amino	amino	NOUN
hjic-1267	98	13	alcohols	alcohol	NOUN
hjic-1267	98	14	from	from	ADP
hjic-1267	98	15	l	l	NOUN
hjic-1267	98	16	-	-	NOUN
hjic-1267	98	17	serine	serine	NOUN
hjic-1267	98	18	,	,	PUNCT
hjic-1267	98	19	j.	j.	PROPN
hjic-1267	98	20	chem	chem	PROPN
hjic-1267	98	21	.	.	PUNCT
hjic-1267	99	1	soc	soc	PROPN
hjic-1267	99	2	.	.	PUNCT
hjic-1267	99	3	,	,	PUNCT
hjic-1267	99	4	perkin	perkin	PROPN
hjic-1267	99	5	trans	trans	PROPN
hjic-1267	99	6	.	.	PROPN
hjic-1267	99	7	1	1	NUM
hjic-1267	99	8	,	,	PUNCT
hjic-1267	99	9	1994	1994	NUM
hjic-1267	99	10	,	,	PUNCT
hjic-1267	99	11	(	(	PUNCT
hjic-1267	99	12	13	13	NUM
hjic-1267	99	13	)	)	PUNCT
hjic-1267	99	14	,	,	PUNCT
hjic-1267	99	15	1675–1678	1675–1678	NUM
hjic-1267	99	16	,	,	PUNCT
hjic-1267	99	17	doi	doi	NOUN
hjic-1267	99	18	:	:	PUNCT
hjic-1267	99	19	10.1039	10.1039	NUM
hjic-1267	99	20	/	/	SYM
hjic-1267	99	21	p19940001675	p19940001675	NOUN
hjic-1267	100	1	[	[	X
hjic-1267	100	2	12	12	NUM
hjic-1267	100	3	]	]	PUNCT
hjic-1267	100	4	sibi	sibi	X
hjic-1267	100	5	,	,	PUNCT
hjic-1267	100	6	m.p	m.p	PROPN
hjic-1267	100	7	.	.	PROPN
hjic-1267	100	8	;	;	PUNCT
hjic-1267	100	9	deshpande	deshpande	PROPN
hjic-1267	100	10	,	,	PUNCT
hjic-1267	100	11	p.k	p.k	PROPN
hjic-1267	100	12	.	.	PUNCT
hjic-1267	100	13	;	;	PUNCT
hjic-1267	100	14	la	la	PROPN
hjic-1267	100	15	loggia	loggia	PROPN
hjic-1267	100	16	,	,	PUNCT
hjic-1267	100	17	a.j	a.j	PROPN
hjic-1267	100	18	.	.	PROPN
hjic-1267	100	19	;	;	PUNCT
hjic-1267	100	20	christensen	christensen	PROPN
hjic-1267	100	21	,	,	PUNCT
hjic-1267	100	22	j.w	j.w	PROPN
hjic-1267	100	23	.	.	PUNCT
hjic-1267	100	24	:	:	PUNCT
hjic-1267	100	25	synthesis	synthesis	NOUN
hjic-1267	100	26	of	of	ADP
hjic-1267	100	27	n	n	CCONJ
hjic-1267	100	28	-	-	PUNCT
hjic-1267	100	29	boc	boc	NOUN
hjic-1267	100	30	-	-	NOUN
hjic-1267	100	31	ddiphenylalanine	ddiphenylalanine	NOUN
hjic-1267	100	32	from	from	ADP
hjic-1267	100	33	l	l	ADJ
hjic-1267	100	34	-	-	ADJ
hjic-1267	100	35	serine	serine	ADJ
hjic-1267	100	36	methyl	methyl	NOUN
hjic-1267	100	37	ester	ester	NOUN
hjic-1267	100	38	hydrochloride	hydrochloride	NOUN
hjic-1267	100	39	,	,	PUNCT
hjic-1267	100	40	tetrahedron	tetrahedron	NOUN
hjic-1267	100	41	lett	lett	PROPN
hjic-1267	100	42	.	.	PROPN
hjic-1267	100	43	,	,	PUNCT
hjic-1267	100	44	1995	1995	NUM
hjic-1267	100	45	,	,	PUNCT
hjic-1267	100	46	36(49	36(49	NOUN
hjic-1267	100	47	)	)	PUNCT
hjic-1267	100	48	,	,	PUNCT
hjic-1267	100	49	8961–8964	8961–8964	NUM
hjic-1267	100	50	,	,	PUNCT
hjic-1267	100	51	doi	doi	NOUN
hjic-1267	100	52	:	:	PUNCT
hjic-1267	100	53	10.1016/0040	10.1016/0040	NUM
hjic-1267	100	54	-	-	SYM
hjic-1267	100	55	4039(95)01983	4039(95)01983	NUM
hjic-1267	100	56	-	-	NOUN
hjic-1267	100	57	o	o	X
hjic-1267	101	1	[	[	X
hjic-1267	101	2	13	13	NUM
hjic-1267	101	3	]	]	X
hjic-1267	101	4	liao	liao	PROPN
hjic-1267	101	5	,	,	PUNCT
hjic-1267	101	6	l.-a	l.-a	PROPN
hjic-1267	101	7	.	.	PUNCT
hjic-1267	101	8	;	;	PUNCT
hjic-1267	101	9	zhang	zhang	PROPN
hjic-1267	101	10	,	,	PUNCT
hjic-1267	101	11	f.	f.	PROPN
hjic-1267	101	12	;	;	PUNCT
hjic-1267	101	13	dmitrenko	dmitrenko	NOUN
hjic-1267	101	14	,	,	PUNCT
hjic-1267	101	15	o.	o.	PROPN
hjic-1267	101	16	;	;	PUNCT
hjic-1267	101	17	bach	bach	PROPN
hjic-1267	101	18	,	,	PUNCT
hjic-1267	101	19	r.d	r.d	PROPN
hjic-1267	101	20	.	.	PROPN
hjic-1267	101	21	;	;	PUNCT
hjic-1267	101	22	fox	fox	PROPN
hjic-1267	101	23	,	,	PUNCT
hjic-1267	101	24	j.m	j.m	PROPN
hjic-1267	101	25	.	.	PROPN
hjic-1267	101	26	:	:	PUNCT
hjic-1267	101	27	a	a	DET
hjic-1267	101	28	reactivity	reactivity	NOUN
hjic-1267	101	29	/	/	SYM
hjic-1267	101	30	affinity	affinity	NOUN
hjic-1267	101	31	switch	switch	NOUN
hjic-1267	101	32	for	for	ADP
hjic-1267	101	33	parallel	parallel	ADJ
hjic-1267	101	34	kinetic	kinetic	ADJ
hjic-1267	101	35	resolution	resolution	NOUN
hjic-1267	101	36	:	:	PUNCT
hjic-1267	101	37	α	α	X
hjic-1267	101	38	-	-	PUNCT
hjic-1267	101	39	amino	amino	ADJ
hjic-1267	101	40	acid	acid	NOUN
hjic-1267	101	41	quasienantiomers	quasienantiomer	NOUN
hjic-1267	101	42	and	and	CCONJ
hjic-1267	101	43	the	the	DET
hjic-1267	101	44	resolution	resolution	NOUN
hjic-1267	101	45	of	of	ADP
hjic-1267	101	46	cyclopropene	cyclopropene	ADJ
hjic-1267	101	47	carboxylic	carboxylic	ADJ
hjic-1267	101	48	acids	acid	NOUN
hjic-1267	101	49	,	,	PUNCT
hjic-1267	101	50	j.	j.	PROPN
hjic-1267	101	51	am	am	PROPN
hjic-1267	101	52	.	.	PUNCT
hjic-1267	101	53	chem	chem	NOUN
hjic-1267	101	54	.	.	PUNCT
hjic-1267	102	1	soc	soc	PROPN
hjic-1267	102	2	.	.	PROPN
hjic-1267	102	3	,	,	PUNCT
hjic-1267	102	4	2004	2004	NUM
hjic-1267	102	5	,	,	PUNCT
hjic-1267	102	6	126(14	126(14	NUM
hjic-1267	102	7	)	)	PUNCT
hjic-1267	102	8	,	,	PUNCT
hjic-1267	102	9	4490–4491	4490–4491	NUM
hjic-1267	102	10	,	,	PUNCT
hjic-1267	102	11	doi	doi	NOUN
hjic-1267	102	12	:	:	PUNCT
hjic-1267	102	13	10.1021	10.1021	NUM
hjic-1267	102	14	/	/	SYM
hjic-1267	102	15	ja049779	ja049779	PROPN
hjic-1267	102	16	t	t	PROPN
hjic-1267	103	1	[	[	X
hjic-1267	103	2	14	14	NUM
hjic-1267	103	3	]	]	X
hjic-1267	103	4	lewis	lewis	PROPN
hjic-1267	103	5	,	,	PUNCT
hjic-1267	103	6	n.	n.	PROPN
hjic-1267	103	7	;	;	PUNCT
hjic-1267	103	8	mckillop	mckillop	PROPN
hjic-1267	103	9	,	,	PUNCT
hjic-1267	103	10	a.	a.	PROPN
hjic-1267	103	11	;	;	PUNCT
hjic-1267	103	12	taylor	taylor	PROPN
hjic-1267	103	13	,	,	PUNCT
hjic-1267	103	14	r.j.k	r.j.k	NOUN
hjic-1267	103	15	.	.	PUNCT
hjic-1267	103	16	;	;	PUNCT
hjic-1267	103	17	watson	watson	PROPN
hjic-1267	103	18	,	,	PUNCT
hjic-1267	103	19	r.j	r.j	PROPN
hjic-1267	103	20	.	.	PROPN
hjic-1267	103	21	:	:	PUNCT
hjic-1267	103	22	a	a	DET
hjic-1267	103	23	simple	simple	ADJ
hjic-1267	103	24	and	and	CCONJ
hjic-1267	103	25	efficient	efficient	ADJ
hjic-1267	103	26	procedure	procedure	NOUN
hjic-1267	103	27	for	for	ADP
hjic-1267	103	28	the	the	DET
hjic-1267	103	29	preparation	preparation	NOUN
hjic-1267	103	30	of	of	ADP
hjic-1267	103	31	chiral	chiral	ADJ
hjic-1267	103	32	2	2	NUM
hjic-1267	103	33	-	-	PUNCT
hjic-1267	103	34	oxazolidinones	oxazolidinone	NOUN
hjic-1267	103	35	from	from	ADP
hjic-1267	103	36	αamino	αamino	NOUN
hjic-1267	103	37	acids	acid	NOUN
hjic-1267	103	38	,	,	PUNCT
hjic-1267	103	39	synth	synth	NOUN
hjic-1267	103	40	.	.	PUNCT
hjic-1267	104	1	commun	commun	PROPN
hjic-1267	104	2	.	.	PROPN
hjic-1267	104	3	,	,	PUNCT
hjic-1267	104	4	1995	1995	NUM
hjic-1267	104	5	,	,	PUNCT
hjic-1267	104	6	25(4	25(4	NOUN
hjic-1267	104	7	)	)	PUNCT
hjic-1267	104	8	,	,	PUNCT
hjic-1267	104	9	561	561	NUM
hjic-1267	104	10	–	–	PUNCT
hjic-1267	104	11	568	568	NUM
hjic-1267	104	12	,	,	PUNCT
hjic-1267	104	13	doi	doi	NOUN
hjic-1267	104	14	:	:	PUNCT
hjic-1267	104	15	10.1080/00397919508011390	10.1080/00397919508011390	NUM
hjic-1267	105	1	[	[	X
hjic-1267	105	2	15	15	NUM
hjic-1267	105	3	]	]	X
hjic-1267	105	4	wuts	wut	NOUN
hjic-1267	105	5	,	,	PUNCT
hjic-1267	105	6	p.g.m	p.g.m	NOUN
hjic-1267	105	7	.	.	PROPN
hjic-1267	105	8	;	;	PUNCT
hjic-1267	105	9	pruitt	pruitt	PROPN
hjic-1267	105	10	,	,	PUNCT
hjic-1267	105	11	l.e	l.e	PROPN
hjic-1267	105	12	.	.	PROPN
hjic-1267	105	13	:	:	PUNCT
hjic-1267	106	1	an	an	DET
hjic-1267	106	2	efficient	efficient	ADJ
hjic-1267	106	3	synthesis	synthesis	NOUN
hjic-1267	106	4	of	of	ADP
hjic-1267	106	5	(	(	PUNCT
hjic-1267	106	6	4s)-(-)-4	4s)-(-)-4	VERB
hjic-1267	106	7	-	-	PUNCT
hjic-1267	106	8	isopropyl-2	isopropyl-2	NUM
hjic-1267	106	9	-	-	PUNCT
hjic-1267	106	10	oxazolidinone	oxazolidinone	NOUN
hjic-1267	106	11	,	,	PUNCT
hjic-1267	106	12	synthesis	synthesis	NOUN
hjic-1267	106	13	,	,	PUNCT
hjic-1267	106	14	1989	1989	NUM
hjic-1267	106	15	,	,	PUNCT
hjic-1267	106	16	1989(8	1989(8	NUM
hjic-1267	106	17	)	)	PUNCT
hjic-1267	106	18	,	,	PUNCT
hjic-1267	106	19	622–623	622–623	NUM
hjic-1267	106	20	,	,	PUNCT
hjic-1267	106	21	doi	doi	NOUN
hjic-1267	106	22	:	:	PUNCT
hjic-1267	106	23	10.1055	10.1055	NUM
hjic-1267	106	24	/	/	SYM
hjic-1267	106	25	s-1989	s-1989	PROPN
hjic-1267	106	26	-	-	PUNCT
hjic-1267	106	27	27337	27337	NUM
hjic-1267	106	28	[	[	X
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hjic-1267	106	30	]	]	PUNCT
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hjic-1267	106	32	,	,	PUNCT
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hjic-1267	106	35	,	,	PUNCT
hjic-1267	106	36	classics	classic	NOUN
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hjic-1267	106	38	total	total	ADJ
hjic-1267	106	39	synthesis	synthesis	NOUN
hjic-1267	106	40	(	(	PUNCT
hjic-1267	106	41	5th	5th	ADJ
hjic-1267	106	42	edition	edition	NOUN
hjic-1267	106	43	)	)	PUNCT
hjic-1267	106	44	(	(	PUNCT
hjic-1267	106	45	wiley	wiley	PROPN
hjic-1267	106	46	-	-	PUNCT
hjic-1267	106	47	vch	vch	PROPN
hjic-1267	106	48	,	,	PUNCT
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hjic-1267	106	50	york	york	PROPN
hjic-1267	106	51	,	,	PUNCT
hjic-1267	106	52	usa	usa	PROPN
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hjic-1267	106	54	,	,	PUNCT
hjic-1267	106	55	2008	2008	NUM
hjic-1267	106	56	,	,	PUNCT
hjic-1267	106	57	pp	pp	ADJ
hjic-1267	106	58	.	.	PUNCT
hjic-1267	107	1	485–508	485–508	NUM
hjic-1267	108	1	[	[	SYM
hjic-1267	108	2	17	17	NUM
hjic-1267	108	3	]	]	PUNCT
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hjic-1267	108	5	,	,	PUNCT
hjic-1267	108	6	m.	m.	NOUN
hjic-1267	108	7	;	;	PUNCT
hjic-1267	108	8	king	king	PROPN
hjic-1267	108	9	,	,	PUNCT
hjic-1267	108	10	g.f	g.f	PROPN
hjic-1267	108	11	.	.	PROPN
hjic-1267	108	12	;	;	PUNCT
hjic-1267	108	13	adams	adams	PROPN
hjic-1267	108	14	,	,	PUNCT
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hjic-1267	108	17	;	;	PUNCT
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hjic-1267	108	19	,	,	PUNCT
hjic-1267	108	20	p.f	p.f	PROPN
hjic-1267	108	21	.	.	PROPN
hjic-1267	108	22	:	:	PUNCT
hjic-1267	108	23	trends	trend	NOUN
hjic-1267	108	24	in	in	ADP
hjic-1267	108	25	peptide	peptide	ADJ
hjic-1267	108	26	drug	drug	NOUN
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hjic-1267	109	2	.	.	PROPN
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hjic-1267	109	4	discov	discov	NOUN
hjic-1267	109	5	.	.	PUNCT
hjic-1267	109	6	,	,	PUNCT
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hjic-1267	109	8	,	,	PUNCT
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hjic-1267	109	10	)	)	PUNCT
hjic-1267	109	11	,	,	PUNCT
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hjic-1267	109	13	,	,	PUNCT
hjic-1267	109	14	doi	doi	NOUN
hjic-1267	109	15	:	:	PUNCT
hjic-1267	109	16	10.1038	10.1038	NUM
hjic-1267	109	17	/	/	SYM
hjic-1267	109	18	s41573	s41573	PROPN
hjic-1267	109	19	-	-	PUNCT
hjic-1267	109	20	020	020	NUM
hjic-1267	109	21	-	-	PUNCT
hjic-1267	109	22	00135	00135	NUM
hjic-1267	109	23	-	-	SYM
hjic-1267	109	24	8	8	NUM
hjic-1267	109	25	https://www.google.com/search?sca_esv=813765718ccf2407&rlz=1c1rxqr_enca1001ca1001&cs=0&q=benzyloxycarbonyl&sa=x&ved=2ahukewinqpfx3oanaxu7tkqehthmiqeqxccnegqibbab&mstk=autexfcfe_lr7lxateue6lqwmounmoxgp4pgdi8y34ia97hrzds1pbob_hm6hhsgduhndbi_xuxehsds8tpkwbv5othu1hjqq5ba_krgitmo3sawmdlsjtzi2gh0himnqemgvtq&csui=3	https://www.google.com/search?sca_esv=813765718ccf2407&rlz=1c1rxqr_enca1001ca1001&cs=0&q=benzyloxycarbonyl&sa=x&ved=2ahukewinqpfx3oanaxu7tkqehthmiqeqxccnegqibbab&mstk=autexfcfe_lr7lxateue6lqwmounmoxgp4pgdi8y34ia97hrzds1pbob_hm6hhsgduhndbi_xuxehsds8tpkwbv5othu1hjqq5ba_krgitmo3sawmdlsjtzi2gh0himnqemgvtq&csui=3	NOUN
hjic-1267	109	26	https://doi.org/10.1021/ed075p1225	https://doi.org/10.1021/ed075p1225	PROPN
hjic-1267	109	27	https://doi.org/10.1021/cen-v082n024.p047	https://doi.org/10.1021/cen-v082n024.p047	PROPN
hjic-1267	109	28	https://doi.org/10.2174/157017907779981552	https://doi.org/10.2174/157017907779981552	PUNCT
hjic-1267	110	1	https://doi.org/10.1021/ja00856a074	https://doi.org/10.1021/ja00856a074	PROPN
hjic-1267	110	2	https://doi.org/10.1021/ja00545a049	https://doi.org/10.1021/ja00545a049	PROPN
hjic-1267	110	3	https://doi.org/10.1021/jo00223a055	https://doi.org/10.1021/jo00223a055	PROPN
hjic-1267	110	4	https://doi.org/10.1021/ja01153a047	https://doi.org/10.1021/ja01153a047	PROPN
hjic-1267	110	5	https://doi.org/10.1039/ct9130300027	https://doi.org/10.1039/ct9130300027	PROPN
hjic-1267	110	6	https://doi.org/10.1039/p19940001675	https://doi.org/10.1039/p19940001675	NUM
hjic-1267	110	7	https://doi.org/10.1016/0040-4039(95)01983-o	https://doi.org/10.1016/0040-4039(95)01983-o	PROPN
hjic-1267	110	8	https://doi.org/10.1021/ja049779	https://doi.org/10.1021/ja049779	PROPN
hjic-1267	110	9	t	t	NOUN
hjic-1267	110	10	https://doi.org/10.1080/00397919508011390	https://doi.org/10.1080/00397919508011390	NOUN
hjic-1267	110	11	https://doi.org/10.1055/s-1989-27337	https://doi.org/10.1055/s-1989-27337	PROPN
hjic-1267	110	12	https://doi.org/10.1038/s41573-020-00135-8	https://doi.org/10.1038/s41573-020-00135-8	PROPN
hjic-1267	110	13	https://doi.org/10.1038/s41573-020-00135-8	https://doi.org/10.1038/s41573-020-00135-8	NUM
hjic-1267	110	14	diastereoselective	diastereoselective	ADJ
hjic-1267	110	15	alkylation	alkylation	NOUN
hjic-1267	110	16	53(2	53(2	NUM
hjic-1267	110	17	)	)	PUNCT
hjic-1267	110	18	pp	pp	ADV
hjic-1267	110	19	.	.	PUNCT
hjic-1267	111	1	49–53	49–53	NUM
hjic-1267	111	2	(	(	PUNCT
hjic-1267	111	3	2025	2025	NUM
hjic-1267	111	4	)	)	PUNCT
hjic-1267	111	5	53	53	NUM
hjic-1267	112	1	[	[	SYM
hjic-1267	112	2	18	18	NUM
hjic-1267	112	3	]	]	PUNCT
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hjic-1267	112	5	,	,	PUNCT
hjic-1267	112	6	h.	h.	PROPN
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hjic-1267	112	8	;	;	PUNCT
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hjic-1267	112	10	,	,	PUNCT
hjic-1267	112	11	c.c	c.c	PROPN
hjic-1267	112	12	.	.	PROPN
hjic-1267	112	13	;	;	PUNCT
hjic-1267	112	14	horne	horne	PROPN
hjic-1267	112	15	,	,	PUNCT
hjic-1267	112	16	w.s	w.s	PROPN
hjic-1267	112	17	.	.	PUNCT
hjic-1267	112	18	:	:	PUNCT
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hjic-1267	112	24	susceptibility	susceptibility	NOUN
hjic-1267	112	25	:	:	PUNCT
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hjic-1267	112	28	modification	modification	NOUN
hjic-1267	112	29	type	type	NOUN
hjic-1267	112	30	,	,	PUNCT
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hjic-1267	112	32	,	,	PUNCT
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hjic-1267	112	36	,	,	PUNCT
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hjic-1267	112	39	2016	2016	NUM
hjic-1267	112	40	,	,	PUNCT
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hjic-1267	112	42	)	)	PUNCT
hjic-1267	112	43	,	,	PUNCT
hjic-1267	112	44	712–718	712–718	NUM
hjic-1267	112	45	,	,	PUNCT
hjic-1267	112	46	doi	doi	NOUN
hjic-1267	112	47	:	:	PUNCT
hjic-1267	112	48	10.1002	10.1002	NUM
hjic-1267	112	49	/	/	SYM
hjic-1267	112	50	cbic.201500312	cbic.201500312	PROPN
hjic-1267	112	51	[	[	X
hjic-1267	112	52	19	19	NUM
hjic-1267	112	53	]	]	ADJ
hjic-1267	112	54	crisma	crisma	NOUN
hjic-1267	112	55	,	,	PUNCT
hjic-1267	112	56	m.	m.	NOUN
hjic-1267	112	57	;	;	PUNCT
hjic-1267	112	58	toniolo	toniolo	NOUN
hjic-1267	112	59	,	,	PUNCT
hjic-1267	112	60	c.	c.	NOUN
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hjic-1267	112	69	chiral	chiral	ADJ
hjic-1267	112	70	,	,	PUNCT
hjic-1267	112	71	cα‐	cα‐	NOUN
hjic-1267	112	72	tetrasubstituted	tetrasubstitute	VERB
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hjic-1267	112	74	acids	acid	NOUN
hjic-1267	112	75	,	,	PUNCT
hjic-1267	112	76	pept	pept	NOUN
hjic-1267	112	77	.	.	PUNCT
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hjic-1267	113	3	,	,	PUNCT
hjic-1267	113	4	2015	2015	NUM
hjic-1267	113	5	,	,	PUNCT
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hjic-1267	113	7	)	)	PUNCT
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hjic-1267	113	12	:	:	PUNCT
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hjic-1267	113	20	,	,	PUNCT
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hjic-1267	113	24	,	,	PUNCT
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hjic-1267	113	30	;	;	PUNCT
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hjic-1267	113	35	;	;	PUNCT
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hjic-1267	114	9	:	:	PUNCT
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hjic-1267	114	23	,	,	PUNCT
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hjic-1267	114	25	.	.	PUNCT
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hjic-1267	115	2	.	.	PUNCT
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hjic-1267	116	6	)	)	PUNCT
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hjic-1267	116	9	,	,	PUNCT
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hjic-1267	116	11	:	:	PUNCT
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hjic-1267	117	9	-	-	PUNCT
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hjic-1267	117	13	;	;	PUNCT
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hjic-1267	117	22	;	;	PUNCT
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hjic-1267	117	38	-	-	PUNCT
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hjic-1267	117	42	:	:	PUNCT
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hjic-1267	117	50	reaction	reaction	NOUN
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hjic-1267	117	55	,	,	PUNCT
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hjic-1267	117	57	)	)	PUNCT
hjic-1267	117	58	,	,	PUNCT
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hjic-1267	117	60	,	,	PUNCT
hjic-1267	117	61	doi	doi	NOUN
hjic-1267	117	62	:	:	PUNCT
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hjic-1267	117	64	/	/	SYM
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hjic-1267	118	2	22	22	NUM
hjic-1267	118	3	]	]	X
hjic-1267	118	4	altmann	altmann	PROPN
hjic-1267	118	5	,	,	PUNCT
hjic-1267	118	6	e.	e.	PROPN
hjic-1267	118	7	;	;	PUNCT
hjic-1267	118	8	nebel	nebel	PROPN
hjic-1267	118	9	,	,	PUNCT
hjic-1267	118	10	k.	k.	PROPN
hjic-1267	118	11	;	;	PUNCT
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hjic-1267	118	13	,	,	PUNCT
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hjic-1267	118	15	:	:	PUNCT
hjic-1267	118	16	versatile	versatile	ADJ
hjic-1267	118	17	stereoselective	stereoselective	ADJ
hjic-1267	118	18	synthesis	synthesis	NOUN
hjic-1267	118	19	of	of	ADP
hjic-1267	118	20	completely	completely	ADV
hjic-1267	118	21	protected	protect	VERB
hjic-1267	118	22	trifunctional	trifunctional	ADJ
hjic-1267	118	23	α‐methylated	α‐methylate	VERB
hjic-1267	118	24	α‐amino	α‐amino	NUM
hjic-1267	118	25	acids	acid	NOUN
hjic-1267	118	26	starting	start	VERB
hjic-1267	118	27	from	from	ADP
hjic-1267	118	28	alanine	alanine	NOUN
hjic-1267	118	29	,	,	PUNCT
hjic-1267	118	30	hel	hel	PROPN
hjic-1267	118	31	.	.	PUNCT
hjic-1267	119	1	chim	chim	PROPN
hjic-1267	119	2	.	.	PUNCT
hjic-1267	120	1	acta	acta	PROPN
hjic-1267	120	2	,	,	PUNCT
hjic-1267	120	3	1991	1991	NUM
hjic-1267	120	4	,	,	PUNCT
hjic-1267	120	5	74(4	74(4	NUM
hjic-1267	120	6	)	)	PUNCT
hjic-1267	120	7	,	,	PUNCT
hjic-1267	120	8	800	800	NUM
hjic-1267	120	9	–	–	PUNCT
hjic-1267	120	10	806	806	NUM
hjic-1267	120	11	,	,	PUNCT
hjic-1267	120	12	doi	doi	NOUN
hjic-1267	120	13	:	:	PUNCT
hjic-1267	120	14	10.1002	10.1002	NUM
hjic-1267	120	15	/	/	SYM
hjic-1267	120	16	hlca.19910740414	hlca.19910740414	X
hjic-1267	121	1	[	[	X
hjic-1267	121	2	23	23	NUM
hjic-1267	121	3	]	]	X
hjic-1267	121	4	doyle	doyle	NOUN
hjic-1267	121	5	,	,	PUNCT
hjic-1267	121	6	m.g.j	m.g.j	NOUN
hjic-1267	121	7	.	.	PUNCT
hjic-1267	121	8	;	;	PUNCT
hjic-1267	121	9	bsharat	bsharat	PROPN
hjic-1267	121	10	,	,	PUNCT
hjic-1267	121	11	o.	o.	PROPN
hjic-1267	121	12	;	;	PUNCT
hjic-1267	121	13	sib	sib	PROPN
hjic-1267	121	14	,	,	PUNCT
hjic-1267	121	15	a.	a.	NOUN
hjic-1267	121	16	;	;	PUNCT
hjic-1267	121	17	derdau	derdau	NOUN
hjic-1267	121	18	,	,	PUNCT
hjic-1267	121	19	v.	v.	PROPN
hjic-1267	121	20	;	;	PUNCT
hjic-1267	121	21	lundgren	lundgren	PROPN
hjic-1267	121	22	,	,	PUNCT
hjic-1267	121	23	r.j	r.j	PROPN
hjic-1267	121	24	.	.	PROPN
hjic-1267	121	25	:	:	PUNCT
hjic-1267	121	26	enantioselective	enantioselective	ADJ
hjic-1267	121	27	carbon	carbon	NOUN
hjic-1267	121	28	isotope	isotope	NOUN
hjic-1267	121	29	exchange	exchange	NOUN
hjic-1267	121	30	,	,	PUNCT
hjic-1267	121	31	j.	j.	PROPN
hjic-1267	121	32	am	am	PROPN
hjic-1267	121	33	.	.	PUNCT
hjic-1267	122	1	chem	chem	NOUN
hjic-1267	122	2	.	.	PUNCT
hjic-1267	123	1	soc	soc	PROPN
hjic-1267	123	2	.	.	PROPN
hjic-1267	123	3	,	,	PUNCT
hjic-1267	123	4	2024	2024	NUM
hjic-1267	123	5	,	,	PUNCT
hjic-1267	123	6	146(28	146(28	NUM
hjic-1267	123	7	)	)	PUNCT
hjic-1267	123	8	,	,	PUNCT
hjic-1267	123	9	18804–18810	18804–18810	NUM
hjic-1267	123	10	,	,	PUNCT
hjic-1267	123	11	doi	doi	NOUN
hjic-1267	123	12	:	:	PUNCT
hjic-1267	123	13	10.1021	10.1021	NUM
hjic-1267	123	14	/	/	SYM
hjic-1267	123	15	jacs.4c03685	jacs.4c03685	PROPN
hjic-1267	124	1	[	[	X
hjic-1267	124	2	24	24	NUM
hjic-1267	124	3	]	]	X
hjic-1267	124	4	doyle	doyle	NOUN
hjic-1267	124	5	,	,	PUNCT
hjic-1267	124	6	m.g.j	m.g.j	NOUN
hjic-1267	124	7	.	.	PUNCT
hjic-1267	124	8	;	;	PUNCT
hjic-1267	124	9	mair	mair	PROPN
hjic-1267	124	10	,	,	PUNCT
hjic-1267	124	11	b.a	b.a	PROPN
hjic-1267	124	12	.	.	PROPN
hjic-1267	124	13	;	;	PUNCT
hjic-1267	124	14	sib	sib	PROPN
hjic-1267	124	15	,	,	PUNCT
hjic-1267	124	16	a.	a.	NOUN
hjic-1267	124	17	;	;	PUNCT
hjic-1267	124	18	bsharat	bsharat	PROPN
hjic-1267	124	19	,	,	PUNCT
hjic-1267	124	20	o.	o.	PROPN
hjic-1267	124	21	;	;	PUNCT
hjic-1267	124	22	munch	munch	PROPN
hjic-1267	124	23	,	,	PUNCT
hjic-1267	124	24	m.	m.	NOUN
hjic-1267	124	25	;	;	PUNCT
hjic-1267	124	26	derdau	derdau	NOUN
hjic-1267	124	27	,	,	PUNCT
hjic-1267	124	28	v.	v.	PROPN
hjic-1267	124	29	;	;	PUNCT
hjic-1267	124	30	rotstein	rotstein	PROPN
hjic-1267	124	31	,	,	PUNCT
hjic-1267	124	32	b.h	b.h	PROPN
hjic-1267	124	33	.	.	PROPN
hjic-1267	124	34	;	;	PUNCT
hjic-1267	124	35	lundgren	lundgren	PROPN
hjic-1267	124	36	,	,	PUNCT
hjic-1267	124	37	r.j	r.j	PROPN
hjic-1267	124	38	.	.	PROPN
hjic-1267	124	39	:	:	PUNCT
hjic-1267	125	1	a	a	DET
hjic-1267	125	2	practical	practical	ADJ
hjic-1267	125	3	guide	guide	NOUN
hjic-1267	125	4	for	for	ADP
hjic-1267	125	5	the	the	DET
hjic-1267	125	6	preparation	preparation	NOUN
hjic-1267	125	7	of	of	ADP
hjic-1267	125	8	c1labeled	c1labele	VERB
hjic-1267	125	9	α	α	NOUN
hjic-1267	125	10	-	-	ADJ
hjic-1267	125	11	amino	amino	ADJ
hjic-1267	125	12	acids	acid	NOUN
hjic-1267	125	13	using	use	VERB
hjic-1267	125	14	aldehyde	aldehyde	NOUN
hjic-1267	125	15	catalysis	catalysis	NOUN
hjic-1267	125	16	with	with	ADP
hjic-1267	125	17	isotopically	isotopically	ADV
hjic-1267	125	18	labeled	label	VERB
hjic-1267	125	19	co2	co2	NOUN
hjic-1267	125	20	,	,	PUNCT
hjic-1267	125	21	nat	nat	PROPN
hjic-1267	125	22	.	.	PUNCT
hjic-1267	126	1	protoc	protoc	PROPN
hjic-1267	126	2	.	.	PUNCT
hjic-1267	127	1	,	,	PUNCT
hjic-1267	127	2	2024	2024	NUM
hjic-1267	127	3	,	,	PUNCT
hjic-1267	127	4	19(7	19(7	NOUN
hjic-1267	127	5	)	)	PUNCT
hjic-1267	127	6	,	,	PUNCT
hjic-1267	127	7	2147–2179	2147–2179	NUM
hjic-1267	127	8	,	,	PUNCT
hjic-1267	127	9	doi	doi	NOUN
hjic-1267	127	10	:	:	PUNCT
hjic-1267	127	11	10.1038	10.1038	NUM
hjic-1267	127	12	/	/	SYM
hjic-1267	127	13	s41596	s41596	NOUN
hjic-1267	127	14	-	-	PUNCT
hjic-1267	127	15	024	024	NUM
hjic-1267	127	16	-	-	PUNCT
hjic-1267	127	17	00974	00974	NUM
hjic-1267	127	18	-	-	SYM
hjic-1267	127	19	4	4	NUM
hjic-1267	127	20	[	[	X
hjic-1267	127	21	25	25	NUM
hjic-1267	127	22	]	]	PUNCT
hjic-1267	127	23	bsharat	bsharat	NOUN
hjic-1267	127	24	,	,	PUNCT
hjic-1267	127	25	o.	o.	NOUN
hjic-1267	127	26	:	:	PUNCT
hjic-1267	127	27	classical	classical	ADJ
hjic-1267	127	28	and	and	CCONJ
hjic-1267	127	29	modern	modern	ADJ
hjic-1267	127	30	methods	method	NOUN
hjic-1267	127	31	for	for	ADP
hjic-1267	127	32	carbon	carbon	NOUN
hjic-1267	127	33	isotope	isotope	NOUN
hjic-1267	127	34	labeling	labeling	NOUN
hjic-1267	127	35	,	,	PUNCT
hjic-1267	127	36	moroc	moroc	NOUN
hjic-1267	127	37	.	.	PUNCT
hjic-1267	128	1	j.	j.	PROPN
hjic-1267	128	2	chem	chem	PROPN
hjic-1267	128	3	.	.	PUNCT
hjic-1267	128	4	,	,	PUNCT
hjic-1267	128	5	2024	2024	NUM
hjic-1267	128	6	,	,	PUNCT
hjic-1267	128	7	12(3	12(3	NUM
hjic-1267	128	8	)	)	PUNCT
hjic-1267	128	9	,	,	PUNCT
hjic-1267	128	10	1110–1121	1110–1121	NUM
hjic-1267	128	11	,	,	PUNCT
hjic-1267	128	12	doi	doi	NOUN
hjic-1267	128	13	:	:	PUNCT
hjic-1267	128	14	10.48317	10.48317	NUM
hjic-1267	128	15	/	/	SYM
hjic-1267	128	16	imist.prsm	imist.prsm	NOUN
hjic-1267	128	17	/	/	SYM
hjic-1267	128	18	morjchem	morjchem	NOUN
hjic-1267	128	19	-	-	PUNCT
hjic-1267	128	20	v12i3.45730	v12i3.45730	ADV
hjic-1267	128	21	[	[	X
hjic-1267	128	22	26	26	NUM
hjic-1267	128	23	]	]	X
hjic-1267	128	24	bsharat	bsharat	NOUN
hjic-1267	128	25	,	,	PUNCT
hjic-1267	128	26	o.	o.	PROPN
hjic-1267	128	27	:	:	PUNCT
hjic-1267	128	28	12c/13c	12c/13c	NUM
hjic-1267	128	29	isotope	isotope	NOUN
hjic-1267	128	30	exchange	exchange	NOUN
hjic-1267	128	31	for	for	ADP
hjic-1267	128	32	the	the	DET
hjic-1267	128	33	synthesis	synthesis	NOUN
hjic-1267	128	34	of	of	ADP
hjic-1267	128	35	d-[13c	d-[13c	NOUN
hjic-1267	128	36	]	]	X
hjic-1267	128	37	phenylalanine	phenylalanine	NOUN
hjic-1267	128	38	by	by	ADP
hjic-1267	128	39	using	use	VERB
hjic-1267	128	40	[	[	X
hjic-1267	128	41	13c	13c	NOUN
hjic-1267	128	42	]	]	X
hjic-1267	128	43	co2	co2	NOUN
hjic-1267	128	44	and	and	CCONJ
hjic-1267	128	45	binol	binol	ADJ
hjic-1267	128	46	chiral	chiral	ADJ
hjic-1267	128	47	aldehyde	aldehyde	NOUN
hjic-1267	128	48	receptor	receptor	NOUN
hjic-1267	128	49	,	,	PUNCT
hjic-1267	128	50	j.	j.	PROPN
hjic-1267	128	51	radioanal	radioanal	PROPN
hjic-1267	128	52	.	.	PUNCT
hjic-1267	129	1	nucl	nucl	PROPN
hjic-1267	129	2	.	.	PUNCT
hjic-1267	130	1	chem	chem	PROPN
hjic-1267	130	2	.	.	PUNCT
hjic-1267	130	3	,	,	PUNCT
hjic-1267	130	4	2025	2025	NUM
hjic-1267	130	5	,	,	PUNCT
hjic-1267	130	6	334(5	334(5	NUM
hjic-1267	130	7	)	)	PUNCT
hjic-1267	130	8	,	,	PUNCT
hjic-1267	130	9	3669	3669	NUM
hjic-1267	130	10	–	–	PUNCT
hjic-1267	130	11	3682	3682	NUM
hjic-1267	130	12	,	,	PUNCT
hjic-1267	130	13	doi	doi	NOUN
hjic-1267	130	14	:	:	PUNCT
hjic-1267	130	15	10.1007	10.1007	NUM
hjic-1267	130	16	/	/	SYM
hjic-1267	130	17	s10967	s10967	NOUN
hjic-1267	130	18	-	-	PUNCT
hjic-1267	130	19	025	025	NUM
hjic-1267	130	20	-	-	PUNCT
hjic-1267	130	21	10073	10073	NUM
hjic-1267	130	22	-	-	SYM
hjic-1267	130	23	7	7	NUM
hjic-1267	131	1	[	[	SYM
hjic-1267	131	2	27	27	NUM
hjic-1267	131	3	]	]	X
hjic-1267	131	4	talybov	talybov	NOUN
hjic-1267	131	5	,	,	PUNCT
hjic-1267	131	6	g.m	g.m	PROPN
hjic-1267	131	7	.	.	PUNCT
hjic-1267	131	8	:	:	PUNCT
hjic-1267	132	1	enantioselective	enantioselective	ADJ
hjic-1267	132	2	catalytic	catalytic	ADJ
hjic-1267	132	3	threecomponent	threecomponent	NOUN
hjic-1267	132	4	synthesis	synthesis	NOUN
hjic-1267	132	5	of	of	ADP
hjic-1267	132	6	optically	optically	ADV
hjic-1267	132	7	active	active	ADJ
hjic-1267	132	8	propargyl	propargyl	NOUN
hjic-1267	132	9	amino	amino	NOUN
hjic-1267	132	10	ethers	ether	NOUN
hjic-1267	132	11	,	,	PUNCT
hjic-1267	132	12	hung	hung	PROPN
hjic-1267	132	13	.	.	PUNCT
hjic-1267	133	1	j.	j.	PROPN
hjic-1267	133	2	ind	ind	PROPN
hjic-1267	133	3	.	.	PUNCT
hjic-1267	134	1	chem	chem	PROPN
hjic-1267	134	2	.	.	PUNCT
hjic-1267	134	3	,	,	PUNCT
hjic-1267	134	4	2025	2025	NUM
hjic-1267	134	5	,	,	PUNCT
hjic-1267	134	6	53(1	53(1	NUM
hjic-1267	134	7	)	)	PUNCT
hjic-1267	134	8	,	,	PUNCT
hjic-1267	134	9	39–42	39–42	NUM
hjic-1267	134	10	,	,	PUNCT
hjic-1267	134	11	doi	doi	NOUN
hjic-1267	134	12	:	:	PUNCT
hjic-1267	134	13	10.33927	10.33927	NUM
hjic-1267	134	14	/	/	SYM
hjic-1267	134	15	hjic-2025	hjic-2025	NOUN
hjic-1267	134	16	-	-	PUNCT
hjic-1267	134	17	05	05	NUM
hjic-1267	135	1	[	[	X
hjic-1267	135	2	28	28	NUM
hjic-1267	135	3	]	]	X
hjic-1267	135	4	bsharat	bsharat	NOUN
hjic-1267	135	5	,	,	PUNCT
hjic-1267	135	6	o.	o.	PROPN
hjic-1267	135	7	;	;	PUNCT
hjic-1267	135	8	salama	salama	PROPN
hjic-1267	135	9	,	,	PUNCT
hjic-1267	135	10	y.	y.	PROPN
hjic-1267	135	11	;	;	PUNCT
hjic-1267	135	12	al	al	PROPN
hjic-1267	135	13	-	-	PUNCT
hjic-1267	135	14	hajj	hajj	PROPN
hjic-1267	135	15	,	,	PUNCT
hjic-1267	135	16	n.	n.	PROPN
hjic-1267	135	17	;	;	PUNCT
hjic-1267	135	18	al	al	PROPN
hjic-1267	135	19	-	-	PUNCT
hjic-1267	135	20	maharik	maharik	PROPN
hjic-1267	135	21	,	,	PUNCT
hjic-1267	135	22	n.	n.	NOUN
hjic-1267	135	23	:	:	PUNCT
hjic-1267	135	24	chiliadenus	chiliadenus	VERB
hjic-1267	135	25	iphionoides	iphionoide	NOUN
hjic-1267	135	26	:	:	PUNCT
hjic-1267	135	27	from	from	ADP
hjic-1267	135	28	chemical	chemical	NOUN
hjic-1267	135	29	profiling	profiling	NOUN
hjic-1267	135	30	to	to	ADP
hjic-1267	135	31	anticancer	anticancer	NOUN
hjic-1267	135	32	,	,	PUNCT
hjic-1267	135	33	antioxidant	antioxidant	NOUN
hjic-1267	135	34	,	,	PUNCT
hjic-1267	135	35	α	α	NOUN
hjic-1267	135	36	-	-	NOUN
hjic-1267	135	37	amylase	amylase	NOUN
hjic-1267	135	38	,	,	PUNCT
hjic-1267	135	39	and	and	CCONJ
hjic-1267	135	40	α	α	X
hjic-1267	135	41	-	-	PUNCT
hjic-1267	135	42	glycosidase	glycosidase	NOUN
hjic-1267	135	43	activities	activity	NOUN
hjic-1267	135	44	,	,	PUNCT
hjic-1267	135	45	plos	plos	PROPN
hjic-1267	135	46	one	one	NUM
hjic-1267	135	47	,	,	PUNCT
hjic-1267	135	48	2025	2025	NUM
hjic-1267	135	49	,	,	PUNCT
hjic-1267	135	50	20(7	20(7	NUM
hjic-1267	135	51	)	)	PUNCT
hjic-1267	135	52	,	,	PUNCT
hjic-1267	135	53	e0327632	e0327632	PROPN
hjic-1267	135	54	,	,	PUNCT
hjic-1267	135	55	doi	doi	NOUN
hjic-1267	135	56	:	:	PUNCT
hjic-1267	136	1	10.1371	10.1371	NUM
hjic-1267	136	2	/	/	SYM
hjic-1267	136	3	journal.pone.0327632	journal.pone.0327632	NOUN
hjic-1267	136	4	[	[	PUNCT
hjic-1267	136	5	29	29	NUM
hjic-1267	136	6	]	]	X
hjic-1267	136	7	al	al	PROPN
hjic-1267	136	8	-	-	PUNCT
hjic-1267	136	9	hajj	hajj	PROPN
hjic-1267	136	10	,	,	PUNCT
hjic-1267	136	11	n.	n.	NOUN
hjic-1267	136	12	;	;	PUNCT
hjic-1267	136	13	bsharat	bsharat	PROPN
hjic-1267	136	14	,	,	PUNCT
hjic-1267	136	15	o.	o.	PROPN
hjic-1267	136	16	;	;	PUNCT
hjic-1267	136	17	jaradat	jaradat	NOUN
hjic-1267	136	18	,	,	PUNCT
hjic-1267	136	19	n.	n.	PROPN
hjic-1267	136	20	;	;	PUNCT
hjic-1267	136	21	abdallah	abdallah	PROPN
hjic-1267	136	22	,	,	PUNCT
hjic-1267	136	23	l.	l.	PROPN
hjic-1267	136	24	;	;	PUNCT
hjic-1267	136	25	mousa	mousa	PROPN
hjic-1267	136	26	,	,	PUNCT
hjic-1267	136	27	m.	m.	NOUN
hjic-1267	136	28	;	;	PUNCT
hjic-1267	136	29	al	al	PROPN
hjic-1267	136	30	-	-	PUNCT
hjic-1267	136	31	maharik	maharik	PROPN
hjic-1267	136	32	,	,	PUNCT
hjic-1267	136	33	n.	n.	NOUN
hjic-1267	136	34	:	:	PUNCT
hjic-1267	136	35	assessing	assess	VERB
hjic-1267	136	36	salvia	salvia	PROPN
hjic-1267	136	37	dominica	dominica	PROPN
hjic-1267	136	38	l.	l.	PROPN
hjic-1267	136	39	:	:	PUNCT
hjic-1267	136	40	from	from	ADP
hjic-1267	136	41	chemical	chemical	NOUN
hjic-1267	136	42	profiling	profiling	NOUN
hjic-1267	136	43	to	to	ADP
hjic-1267	136	44	antioxidant	antioxidant	ADJ
hjic-1267	136	45	,	,	PUNCT
hjic-1267	136	46	antimicrobial	antimicrobial	ADJ
hjic-1267	136	47	,	,	PUNCT
hjic-1267	136	48	anticancer	anticancer	NOUN
hjic-1267	136	49	,	,	PUNCT
hjic-1267	136	50	α	α	NOUN
hjic-1267	136	51	-	-	NOUN
hjic-1267	136	52	amylase	amylase	NOUN
hjic-1267	136	53	,	,	PUNCT
hjic-1267	136	54	and	and	CCONJ
hjic-1267	136	55	αglycosidase	αglycosidase	NOUN
hjic-1267	136	56	activities	activity	NOUN
hjic-1267	136	57	of	of	ADP
hjic-1267	136	58	the	the	DET
hjic-1267	136	59	plant	plant	NOUN
hjic-1267	136	60	essential	essential	ADJ
hjic-1267	136	61	oil	oil	NOUN
hjic-1267	136	62	,	,	PUNCT
hjic-1267	136	63	chem	chem	NOUN
hjic-1267	136	64	.	.	PUNCT
hjic-1267	137	1	biol	biol	PROPN
hjic-1267	137	2	.	.	PUNCT
hjic-1267	138	1	technol	technol	PROPN
hjic-1267	138	2	.	.	PUNCT
hjic-1267	138	3	agric	agric	PROPN
hjic-1267	138	4	.	.	PROPN
hjic-1267	138	5	,	,	PUNCT
hjic-1267	138	6	2025	2025	NUM
hjic-1267	138	7	,	,	PUNCT
hjic-1267	138	8	12(1	12(1	NUM
hjic-1267	138	9	)	)	PUNCT
hjic-1267	138	10	,	,	PUNCT
hjic-1267	138	11	94	94	NUM
hjic-1267	138	12	,	,	PUNCT
hjic-1267	138	13	doi	doi	NOUN
hjic-1267	138	14	:	:	PUNCT
hjic-1267	138	15	10.1186	10.1186	NUM
hjic-1267	138	16	/	/	SYM
hjic-1267	138	17	s40538	s40538	NOUN
hjic-1267	138	18	-	-	PUNCT
hjic-1267	138	19	025	025	NUM
hjic-1267	138	20	-	-	PUNCT
hjic-1267	138	21	00772	00772	NUM
hjic-1267	138	22	-	-	SYM
hjic-1267	138	23	4	4	NUM
hjic-1267	138	24	[	[	SYM
hjic-1267	138	25	30	30	NUM
hjic-1267	138	26	]	]	X
hjic-1267	138	27	warad	warad	NOUN
hjic-1267	138	28	,	,	PUNCT
hjic-1267	138	29	i.	i.	PROPN
hjic-1267	138	30	,	,	PUNCT
hjic-1267	138	31	bsharat	bsharat	PROPN
hjic-1267	138	32	,	,	PUNCT
hjic-1267	138	33	o.	o.	PROPN
hjic-1267	138	34	,	,	PUNCT
hjic-1267	138	35	tabti	tabti	NOUN
hjic-1267	138	36	,	,	PUNCT
hjic-1267	138	37	s.	s.	PROPN
hjic-1267	138	38	,	,	PUNCT
hjic-1267	138	39	djedouani	djedouani	PROPN
hjic-1267	138	40	,	,	PUNCT
hjic-1267	138	41	a.	a.	NOUN
hjic-1267	138	42	,	,	PUNCT
hjic-1267	138	43	alnuri	alnuri	PROPN
hjic-1267	138	44	,	,	PUNCT
hjic-1267	138	45	m.	m.	NOUN
hjic-1267	138	46	,	,	PUNCT
hjic-1267	138	47	al	al	PROPN
hjic-1267	138	48	-	-	PUNCT
hjic-1267	138	49	zaqri	zaqri	PROPN
hjic-1267	138	50	,	,	PUNCT
hjic-1267	138	51	n.	n.	NOUN
hjic-1267	138	52	,	,	PUNCT
hjic-1267	138	53	kumara	kumara	PROPN
hjic-1267	138	54	,	,	PUNCT
hjic-1267	138	55	k.	k.	PROPN
hjic-1267	138	56	,	,	PUNCT
hjic-1267	138	57	lokanath	lokanath	PROPN
hjic-1267	138	58	,	,	PUNCT
hjic-1267	138	59	n.k	n.k	PROPN
hjic-1267	138	60	.	.	PROPN
hjic-1267	138	61	,	,	PUNCT
hjic-1267	138	62	amereih	amereih	PROPN
hjic-1267	138	63	,	,	PUNCT
hjic-1267	138	64	s.	s.	PROPN
hjic-1267	138	65	;	;	PUNCT
hjic-1267	138	66	abu	abu	PROPN
hjic-1267	138	67	-	-	PUNCT
hjic-1267	138	68	reidah	reidah	PROPN
hjic-1267	138	69	,	,	PUNCT
hjic-1267	138	70	i.m	i.m	PROPN
hjic-1267	138	71	.	.	PUNCT
hjic-1267	138	72	:	:	PUNCT
hjic-1267	139	1	crystal	crystal	NOUN
hjic-1267	139	2	interactions	interaction	NOUN
hjic-1267	139	3	,	,	PUNCT
hjic-1267	139	4	computational	computational	ADJ
hjic-1267	139	5	,	,	PUNCT
hjic-1267	139	6	spectral	spectral	ADJ
hjic-1267	139	7	and	and	CCONJ
hjic-1267	139	8	thermal	thermal	ADJ
hjic-1267	139	9	analysis	analysis	NOUN
hjic-1267	139	10	of	of	ADP
hjic-1267	139	11	(	(	PUNCT
hjic-1267	139	12	e)-n'-(thiophen-2	e)-n'-(thiophen-2	X
hjic-1267	139	13	-	-	PUNCT
hjic-1267	139	14	ylmethylene)isonicotinohydrazide	ylmethylene)isonicotinohydrazide	NOUN
hjic-1267	139	15	as	as	ADP
hjic-1267	139	16	o	o	NOUN
hjic-1267	139	17	-	-	PUNCT
hjic-1267	139	18	n	n	CCONJ
hjic-1267	139	19	-	-	PUNCT
hjic-1267	139	20	s	s	NOUN
hjic-1267	139	21	-	-	PUNCT
hjic-1267	139	22	tridentate	tridentate	ADJ
hjic-1267	139	23	schiff	schiff	NOUN
hjic-1267	139	24	base	base	PROPN
hjic-1267	139	25	ligand	ligand	PROPN
hjic-1267	139	26	,	,	PUNCT
hjic-1267	139	27	j.	j.	PROPN
hjic-1267	139	28	mol	mol	PROPN
hjic-1267	139	29	.	.	PROPN
hjic-1267	139	30	struct	struct	NOUN
hjic-1267	139	31	.	.	PUNCT
hjic-1267	139	32	,	,	PUNCT
hjic-1267	139	33	2019	2019	NUM
hjic-1267	139	34	,	,	PUNCT
hjic-1267	139	35	1185	1185	NUM
hjic-1267	139	36	,	,	PUNCT
hjic-1267	139	37	290–299	290–299	NUM
hjic-1267	139	38	,	,	PUNCT
hjic-1267	139	39	doi	doi	NOUN
hjic-1267	139	40	:	:	PUNCT
hjic-1267	139	41	10.1016	10.1016	NUM
hjic-1267	139	42	/	/	SYM
hjic-1267	139	43	j.molstruc.2019.02.109	j.molstruc.2019.02.109	VERB
hjic-1267	139	44	https://doi.org/10.1002/cbic.201500312	https://doi.org/10.1002/cbic.201500312	PROPN
hjic-1267	139	45	https://doi.org/10.1002/bip.22581	https://doi.org/10.1002/bip.22581	PROPN
hjic-1267	139	46	https://doi.org/10.1002/chem.201102366	https://doi.org/10.1002/chem.201102366	PROPN
hjic-1267	139	47	https://doi.org/10.1016/j.tet.2011.09.083	https://doi.org/10.1016/j.tet.2011.09.083	PROPN
hjic-1267	140	1	https://doi.org/10.1002/hlca.19910740414	https://doi.org/10.1002/hlca.19910740414	NOUN
hjic-1267	140	2	https://doi.org/10.1021/jacs.4c03685	https://doi.org/10.1021/jacs.4c03685	PROPN
hjic-1267	140	3	https://doi.org/10.1038/s41596-024-00974-4	https://doi.org/10.1038/s41596-024-00974-4	NUM
hjic-1267	140	4	https://doi.org/10.48317/imist.prsm/morjchem-v12i3.45730	https://doi.org/10.48317/imist.prsm/morjchem-v12i3.45730	NOUN
hjic-1267	141	1	https://doi.org/10.1007/s10967-025-10073-7	https://doi.org/10.1007/s10967-025-10073-7	X
hjic-1267	141	2	https://doi.org/10.33927/hjic-2025-05	https://doi.org/10.33927/hjic-2025-05	PROPN
hjic-1267	142	1	https://doi.org/10.1371/journal.pone.0327632	https://doi.org/10.1371/journal.pone.0327632	VERB
hjic-1267	142	2	https://doi.org/10.1186/s40538-025-00772-4	https://doi.org/10.1186/s40538-025-00772-4	NUM
hjic-1267	142	3	https://doi.org/10.1016/j.molstruc.2019.02.109	https://doi.org/10.1016/j.molstruc.2019.02.109	VERB