id	sid	tid	token	lemma	pos
hjic-87	1	1	microsoft	microsoft	PROPN
hjic-87	1	2	word	word	NOUN
hjic-87	1	3	szolcs_eloszo.doc	szolcs_eloszo.doc	PROPN
hjic-87	1	4	hungarian	hungarian	ADJ
hjic-87	1	5	journal	journal	NOUN
hjic-87	1	6	of	of	ADP
hjic-87	1	7	industrial	industrial	ADJ
hjic-87	1	8	chemistry	chemistry	NOUN
hjic-87	1	9	veszprém	veszprém	NOUN
hjic-87	1	10	vol	vol	NOUN
hjic-87	1	11	.	.	PUNCT
hjic-87	2	1	32	32	NUM
hjic-87	2	2	.	.	PUNCT
hjic-87	3	1	pp	pp	ADJ
hjic-87	3	2	.	.	PUNCT
hjic-87	4	1	41	41	NUM
hjic-87	4	2	-	-	SYM
hjic-87	4	3	56	56	NUM
hjic-87	4	4	(	(	PUNCT
hjic-87	4	5	2004	2004	NUM
hjic-87	4	6	)	)	PUNCT
hjic-87	4	7	novel	novel	ADJ
hjic-87	4	8	particle	particle	NOUN
hjic-87	4	9	engineering	engineering	NOUN
hjic-87	4	10	techniques	technique	NOUN
hjic-87	4	11	in	in	ADP
hjic-87	4	12	drug	drug	NOUN
hjic-87	4	13	delivery	delivery	NOUN
hjic-87	4	14	:	:	PUNCT
hjic-87	4	15	review	review	NOUN
hjic-87	4	16	of	of	ADP
hjic-87	4	17	coformulations	coformulation	NOUN
hjic-87	4	18	using	use	VERB
hjic-87	4	19	supercritical	supercritical	ADJ
hjic-87	4	20	fluids	fluid	NOUN
hjic-87	4	21	and	and	CCONJ
hjic-87	4	22	liquefied	liquefy	VERB
hjic-87	4	23	gases	gas	NOUN
hjic-87	4	24	v.	v.	ADP
hjic-87	4	25	majerik1	majerik1	PROPN
hjic-87	4	26	,	,	PUNCT
hjic-87	4	27	g.	g.	PROPN
hjic-87	4	28	horváth1	horváth1	PROPN
hjic-87	4	29	,	,	PUNCT
hjic-87	4	30	g.	g.	PROPN
hjic-87	4	31	charbit2	charbit2	PROPN
hjic-87	4	32	,	,	PUNCT
hjic-87	4	33	e.	e.	PROPN
hjic-87	4	34	badens2	badens2	PROPN
hjic-87	4	35	,	,	PUNCT
hjic-87	4	36	l.	l.	PROPN
hjic-87	4	37	szokonya1	szokonya1	PROPN
hjic-87	4	38	,	,	PUNCT
hjic-87	4	39	n.	n.	PROPN
hjic-87	4	40	bosc3	bosc3	PROPN
hjic-87	4	41	and	and	CCONJ
hjic-87	4	42	e.	e.	PROPN
hjic-87	4	43	teillaud3	teillaud3	PROPN
hjic-87	4	44	1department	1department	NUM
hjic-87	4	45	of	of	ADP
hjic-87	4	46	chemical	chemical	NOUN
hjic-87	4	47	engineering	engineering	NOUN
hjic-87	4	48	science	science	NOUN
hjic-87	4	49	,	,	PUNCT
hjic-87	4	50	university	university	NOUN
hjic-87	4	51	of	of	ADP
hjic-87	4	52	veszprém	veszprém	NOUN
hjic-87	4	53	,	,	PUNCT
hjic-87	4	54	p.o	p.o	PROPN
hjic-87	4	55	.	.	PROPN
hjic-87	4	56	box	box	PROPN
hjic-87	4	57	158	158	NUM
hjic-87	4	58	,	,	PUNCT
hjic-87	4	59	h-8201	h-8201	PROPN
hjic-87	4	60	,	,	PUNCT
hjic-87	4	61	hungary	hungary	PROPN
hjic-87	4	62	2laboratoire	2laboratoire	NUM
hjic-87	4	63	de	de	X
hjic-87	4	64	procédés	procédés	PROPN
hjic-87	4	65	propres	propre	NOUN
hjic-87	4	66	et	et	PROPN
hjic-87	4	67	environnement	environnement	PROPN
hjic-87	4	68	(	(	PUNCT
hjic-87	4	69	lppe	lppe	PROPN
hjic-87	4	70	)	)	PUNCT
hjic-87	4	71	,	,	PUNCT
hjic-87	4	72	europôle	europôle	VERB
hjic-87	4	73	de	de	X
hjic-87	4	74	l’arbois	l’arbois	PROPN
hjic-87	4	75	,	,	PUNCT
hjic-87	4	76	domaine	domaine	X
hjic-87	4	77	du	du	PROPN
hjic-87	4	78	petit	petit	PROPN
hjic-87	4	79	arbois	arbois	PROPN
hjic-87	4	80	,	,	PUNCT
hjic-87	4	81	rd	rd	PROPN
hjic-87	4	82	543	543	NUM
hjic-87	4	83	,	,	PUNCT
hjic-87	4	84	13545	13545	NUM
hjic-87	4	85	aix	aix	PROPN
hjic-87	4	86	-	-	PUNCT
hjic-87	4	87	en	en	NOUN
hjic-87	4	88	-	-	PUNCT
hjic-87	4	89	provence	provence	NOUN
hjic-87	4	90	cedex	cedex	NOUN
hjic-87	4	91	04	04	PROPN
hjic-87	4	92	,	,	PUNCT
hjic-87	4	93	france	france	PROPN
hjic-87	4	94	3merck	3merck	NUM
hjic-87	4	95	santé	santé	NOUN
hjic-87	4	96	,	,	PUNCT
hjic-87	4	97	37	37	NUM
hjic-87	4	98	rue	rue	PROPN
hjic-87	4	99	st	st	PROPN
hjic-87	4	100	romain	romain	PROPN
hjic-87	4	101	69379	69379	NUM
hjic-87	4	102	lyon	lyon	PROPN
hjic-87	4	103	cedex	cedex	PROPN
hjic-87	4	104	08	08	PROPN
hjic-87	4	105	,	,	PUNCT
hjic-87	4	106	france	france	PROPN
hjic-87	4	107	contact	contact	NOUN
hjic-87	4	108	information	information	NOUN
hjic-87	4	109	:	:	PUNCT
hjic-87	4	110	majerikv@almos.vein.hu	majerikv@almos.vein.hu	VERB
hjic-87	4	111	this	this	DET
hjic-87	4	112	paper	paper	NOUN
hjic-87	4	113	aimed	aim	VERB
hjic-87	4	114	to	to	PART
hjic-87	4	115	survey	survey	VERB
hjic-87	4	116	the	the	DET
hjic-87	4	117	numerous	numerous	ADJ
hjic-87	4	118	publications	publication	NOUN
hjic-87	4	119	and	and	CCONJ
hjic-87	4	120	patents	patent	NOUN
hjic-87	4	121	issued	issue	VERB
hjic-87	4	122	in	in	ADP
hjic-87	4	123	the	the	DET
hjic-87	4	124	fields	field	NOUN
hjic-87	4	125	of	of	ADP
hjic-87	4	126	supercritical	supercritical	ADJ
hjic-87	4	127	fluid	fluid	NOUN
hjic-87	4	128	assisted	assist	VERB
hjic-87	4	129	and	and	CCONJ
hjic-87	4	130	cryogenic	cryogenic	NOUN
hjic-87	4	131	formulation	formulation	NOUN
hjic-87	4	132	techniques	technique	NOUN
hjic-87	4	133	with	with	ADP
hjic-87	4	134	special	special	ADJ
hjic-87	4	135	regard	regard	NOUN
hjic-87	4	136	to	to	ADP
hjic-87	4	137	coformulations	coformulation	NOUN
hjic-87	4	138	of	of	ADP
hjic-87	4	139	active	active	ADJ
hjic-87	4	140	substrate	substrate	NOUN
hjic-87	4	141	–	–	PUNCT
hjic-87	4	142	excipient	excipient	ADJ
hjic-87	4	143	composites	composite	NOUN
hjic-87	4	144	.	.	PUNCT
hjic-87	5	1	these	these	DET
hjic-87	5	2	methods	method	NOUN
hjic-87	5	3	open	open	VERB
hjic-87	5	4	new	new	ADJ
hjic-87	5	5	possibilities	possibility	NOUN
hjic-87	5	6	in	in	ADP
hjic-87	5	7	formulation	formulation	NOUN
hjic-87	5	8	of	of	ADP
hjic-87	5	9	drug	drug	NOUN
hjic-87	5	10	carrier	carrier	NOUN
hjic-87	5	11	composites	composite	NOUN
hjic-87	5	12	with	with	ADP
hjic-87	5	13	targeted	target	VERB
hjic-87	5	14	physical	physical	ADJ
hjic-87	5	15	properties	property	NOUN
hjic-87	5	16	including	include	VERB
hjic-87	5	17	particle	particle	NOUN
hjic-87	5	18	size	size	NOUN
hjic-87	5	19	,	,	PUNCT
hjic-87	5	20	morphology	morphology	NOUN
hjic-87	5	21	,	,	PUNCT
hjic-87	5	22	crystallinity	crystallinity	NOUN
hjic-87	5	23	,	,	PUNCT
hjic-87	5	24	polymorphism	polymorphism	NOUN
hjic-87	5	25	and	and	CCONJ
hjic-87	5	26	residual	residual	ADJ
hjic-87	5	27	solvent	solvent	NOUN
hjic-87	5	28	content	content	NOUN
hjic-87	5	29	both	both	DET
hjic-87	5	30	methods	method	NOUN
hjic-87	5	31	were	be	AUX
hjic-87	5	32	proved	prove	VERB
hjic-87	5	33	to	to	PART
hjic-87	5	34	be	be	AUX
hjic-87	5	35	viable	viable	ADJ
hjic-87	5	36	alternatives	alternative	NOUN
hjic-87	5	37	to	to	ADP
hjic-87	5	38	conventional	conventional	ADJ
hjic-87	5	39	formulation	formulation	NOUN
hjic-87	5	40	techniques	technique	NOUN
hjic-87	5	41	.	.	PUNCT
hjic-87	6	1	introduction	introduction	NOUN
hjic-87	6	2	lately	lately	ADV
hjic-87	6	3	,	,	PUNCT
hjic-87	6	4	coformulations	coformulation	NOUN
hjic-87	6	5	of	of	ADP
hjic-87	6	6	active	active	ADJ
hjic-87	6	7	pharmaceutical	pharmaceutical	ADJ
hjic-87	6	8	ingredients	ingredient	NOUN
hjic-87	6	9	(	(	PUNCT
hjic-87	6	10	api	api	NOUN
hjic-87	6	11	)	)	PUNCT
hjic-87	6	12	with	with	ADP
hjic-87	6	13	biodegradable	biodegradable	ADJ
hjic-87	6	14	polymers	polymer	NOUN
hjic-87	6	15	draw	draw	VERB
hjic-87	6	16	more	more	ADJ
hjic-87	6	17	and	and	CCONJ
hjic-87	6	18	more	more	ADJ
hjic-87	6	19	attention	attention	NOUN
hjic-87	6	20	.	.	PUNCT
hjic-87	7	1	composites	composite	NOUN
hjic-87	7	2	of	of	ADP
hjic-87	7	3	drugexcipinet	drugexcipinet	NOUN
hjic-87	7	4	systems	system	NOUN
hjic-87	7	5	are	be	AUX
hjic-87	7	6	widely	widely	ADV
hjic-87	7	7	used	use	VERB
hjic-87	7	8	in	in	ADP
hjic-87	7	9	controlled	control	VERB
hjic-87	7	10	delivery	delivery	NOUN
hjic-87	7	11	systems	system	NOUN
hjic-87	7	12	and	and	CCONJ
hjic-87	7	13	formulation	formulation	NOUN
hjic-87	7	14	of	of	ADP
hjic-87	7	15	water	water	NOUN
hjic-87	7	16	insoluble	insoluble	ADJ
hjic-87	7	17	apis	apis	PROPN
hjic-87	7	18	.	.	PUNCT
hjic-87	8	1	in	in	ADP
hjic-87	8	2	controlled	control	VERB
hjic-87	8	3	drug	drug	NOUN
hjic-87	8	4	delivery	delivery	NOUN
hjic-87	8	5	the	the	DET
hjic-87	8	6	release	release	NOUN
hjic-87	8	7	of	of	ADP
hjic-87	8	8	the	the	DET
hjic-87	8	9	api	api	NOUN
hjic-87	8	10	may	may	AUX
hjic-87	8	11	be	be	AUX
hjic-87	8	12	constant	constant	ADJ
hjic-87	8	13	or	or	CCONJ
hjic-87	8	14	cyclic	cyclic	ADJ
hjic-87	8	15	over	over	ADP
hjic-87	8	16	a	a	DET
hjic-87	8	17	long	long	ADJ
hjic-87	8	18	period	period	NOUN
hjic-87	8	19	,	,	PUNCT
hjic-87	8	20	or	or	CCONJ
hjic-87	8	21	it	it	PRON
hjic-87	8	22	may	may	AUX
hjic-87	8	23	be	be	AUX
hjic-87	8	24	triggered	trigger	VERB
hjic-87	8	25	by	by	ADP
hjic-87	8	26	the	the	DET
hjic-87	8	27	environment	environment	NOUN
hjic-87	8	28	(	(	PUNCT
hjic-87	8	29	ph	ph	ADJ
hjic-87	8	30	,	,	PUNCT
hjic-87	8	31	enzymes	enzyme	NOUN
hjic-87	8	32	,	,	PUNCT
hjic-87	8	33	temperature	temperature	NOUN
hjic-87	8	34	,	,	PUNCT
hjic-87	8	35	ion	ion	NOUN
hjic-87	8	36	strength	strength	NOUN
hjic-87	8	37	,	,	PUNCT
hjic-87	8	38	chemical	chemical	NOUN
hjic-87	8	39	species	specie	NOUN
hjic-87	8	40	,	,	PUNCT
hjic-87	8	41	etc	etc	X
hjic-87	8	42	.	.	X
hjic-87	8	43	)	)	PUNCT
hjic-87	8	44	.	.	PUNCT
hjic-87	9	1	the	the	DET
hjic-87	9	2	main	main	ADJ
hjic-87	9	3	goal	goal	NOUN
hjic-87	9	4	of	of	ADP
hjic-87	9	5	controlled	control	VERB
hjic-87	9	6	drug	drug	NOUN
hjic-87	9	7	delivery	delivery	NOUN
hjic-87	9	8	is	be	AUX
hjic-87	9	9	to	to	PART
hjic-87	9	10	achieve	achieve	VERB
hjic-87	9	11	more	more	ADV
hjic-87	9	12	effective	effective	ADJ
hjic-87	9	13	therapies	therapy	NOUN
hjic-87	9	14	with	with	ADP
hjic-87	9	15	fewer	few	ADJ
hjic-87	9	16	administrations	administration	NOUN
hjic-87	9	17	and	and	CCONJ
hjic-87	9	18	avoid	avoid	VERB
hjic-87	9	19	both	both	DET
hjic-87	9	20	underand	underand	NOUN
hjic-87	9	21	overdosing	overdosing	NOUN
hjic-87	9	22	.	.	PUNCT
hjic-87	10	1	depending	depend	VERB
hjic-87	10	2	on	on	ADP
hjic-87	10	3	the	the	DET
hjic-87	10	4	route	route	NOUN
hjic-87	10	5	of	of	ADP
hjic-87	10	6	administration	administration	NOUN
hjic-87	10	7	(	(	PUNCT
hjic-87	10	8	oral	oral	ADJ
hjic-87	10	9	,	,	PUNCT
hjic-87	10	10	transdermal	transdermal	ADJ
hjic-87	10	11	,	,	PUNCT
hjic-87	10	12	parenteral	parenteral	ADJ
hjic-87	10	13	,	,	PUNCT
hjic-87	10	14	intranasal	intranasal	NOUN
hjic-87	10	15	,	,	PUNCT
hjic-87	10	16	intravenous	intravenous	ADJ
hjic-87	10	17	,	,	PUNCT
hjic-87	10	18	intramuscular	intramuscular	ADJ
hjic-87	10	19	,	,	PUNCT
hjic-87	10	20	subcutaneous	subcutaneous	ADJ
hjic-87	10	21	or	or	CCONJ
hjic-87	10	22	intraocular	intraocular	ADJ
hjic-87	10	23	)	)	PUNCT
hjic-87	10	24	drug	drug	NOUN
hjic-87	10	25	formulation	formulation	NOUN
hjic-87	10	26	techniques	technique	NOUN
hjic-87	10	27	must	must	AUX
hjic-87	10	28	meet	meet	VERB
hjic-87	10	29	additional	additional	ADJ
hjic-87	10	30	requirements	requirement	NOUN
hjic-87	10	31	concerning	concern	VERB
hjic-87	10	32	the	the	DET
hjic-87	10	33	physical	physical	ADJ
hjic-87	10	34	properties	property	NOUN
hjic-87	10	35	of	of	ADP
hjic-87	10	36	dry	dry	ADJ
hjic-87	10	37	powder	powder	NOUN
hjic-87	10	38	or	or	CCONJ
hjic-87	10	39	emulsion	emulsion	NOUN
hjic-87	10	40	.	.	PUNCT
hjic-87	11	1	one	one	NUM
hjic-87	11	2	of	of	ADP
hjic-87	11	3	these	these	DET
hjic-87	11	4	properties	property	NOUN
hjic-87	11	5	is	be	AUX
hjic-87	11	6	the	the	DET
hjic-87	11	7	particle	particle	NOUN
hjic-87	11	8	size	size	NOUN
hjic-87	11	9	.	.	PUNCT
hjic-87	12	1	for	for	ADP
hjic-87	12	2	instant	instant	NOUN
hjic-87	12	3	,	,	PUNCT
hjic-87	12	4	only	only	ADJ
hjic-87	12	5	nanoparticles	nanoparticle	NOUN
hjic-87	12	6	can	can	AUX
hjic-87	12	7	be	be	AUX
hjic-87	12	8	injected	inject	VERB
hjic-87	12	9	intravenously	intravenously	ADV
hjic-87	12	10	while	while	SCONJ
hjic-87	12	11	particles	particle	NOUN
hjic-87	12	12	in	in	ADP
hjic-87	12	13	the	the	DET
hjic-87	12	14	range	range	NOUN
hjic-87	12	15	of	of	ADP
hjic-87	12	16	1	1	NUM
hjic-87	12	17	-	-	SYM
hjic-87	12	18	5	5	NUM
hjic-87	12	19	µm	µm	NOUN
hjic-87	12	20	are	be	AUX
hjic-87	12	21	suitable	suitable	ADJ
hjic-87	12	22	for	for	ADP
hjic-87	12	23	pulmonary	pulmonary	ADJ
hjic-87	12	24	delivery	delivery	NOUN
hjic-87	12	25	,	,	PUNCT
hjic-87	12	26	particles	particle	NOUN
hjic-87	12	27	ranging	range	VERB
hjic-87	12	28	from	from	ADP
hjic-87	12	29	5	5	NUM
hjic-87	12	30	to	to	PART
hjic-87	12	31	100	100	NUM
hjic-87	12	32	µm	µm	NUM
hjic-87	12	33	are	be	AUX
hjic-87	12	34	subcutaneously	subcutaneously	ADV
hjic-87	12	35	injectable	injectable	ADJ
hjic-87	12	36	.	.	PUNCT
hjic-87	13	1	conventional	conventional	ADJ
hjic-87	13	2	techniques	technique	NOUN
hjic-87	13	3	for	for	ADP
hjic-87	13	4	the	the	DET
hjic-87	13	5	production	production	NOUN
hjic-87	13	6	of	of	ADP
hjic-87	13	7	drug	drug	NOUN
hjic-87	13	8	-	-	PUNCT
hjic-87	13	9	loaded	load	VERB
hjic-87	13	10	microparticles	microparticle	NOUN
hjic-87	13	11	including	include	VERB
hjic-87	13	12	emulsion	emulsion	NOUN
hjic-87	13	13	and	and	CCONJ
hjic-87	13	14	double	double	ADJ
hjic-87	13	15	-	-	PUNCT
hjic-87	13	16	emulsion	emulsion	NOUN
hjic-87	13	17	solvent	solvent	NOUN
hjic-87	13	18	extraction	extraction	NOUN
hjic-87	13	19	,	,	PUNCT
hjic-87	13	20	spray	spray	VERB
hjic-87	13	21	and	and	CCONJ
hjic-87	13	22	freeze	freeze	VERB
hjic-87	13	23	drying	dry	VERB
hjic-87	13	24	,	,	PUNCT
hjic-87	13	25	liquid	liquid	ADJ
hjic-87	13	26	antisolvent	antisolvent	NOUN
hjic-87	13	27	and	and	CCONJ
hjic-87	13	28	solvent	solvent	ADJ
hjic-87	13	29	evaporation	evaporation	NOUN
hjic-87	13	30	are	be	AUX
hjic-87	13	31	generally	generally	ADV
hjic-87	13	32	associated	associate	VERB
hjic-87	13	33	with	with	ADP
hjic-87	13	34	high	high	ADJ
hjic-87	13	35	residual	residual	ADJ
hjic-87	13	36	solvent	solvent	NOUN
hjic-87	13	37	contents	content	NOUN
hjic-87	13	38	,	,	PUNCT
hjic-87	13	39	low	low	ADJ
hjic-87	13	40	encapsulation	encapsulation	NOUN
hjic-87	13	41	efficiencies	efficiency	NOUN
hjic-87	13	42	and	and	CCONJ
hjic-87	13	43	thermal	thermal	ADJ
hjic-87	13	44	degradations	degradation	NOUN
hjic-87	13	45	.	.	PUNCT
hjic-87	14	1	apart	apart	ADV
hjic-87	14	2	from	from	ADP
hjic-87	14	3	spray	spray	NOUN
hjic-87	14	4	-	-	PUNCT
hjic-87	14	5	drying	dry	VERB
hjic-87	14	6	all	all	PRON
hjic-87	14	7	of	of	ADP
hjic-87	14	8	these	these	DET
hjic-87	14	9	techniques	technique	NOUN
hjic-87	14	10	are	be	AUX
hjic-87	14	11	multi	multi	ADJ
hjic-87	14	12	-	-	ADJ
hjic-87	14	13	stage	stage	NOUN
hjic-87	14	14	processes	process	NOUN
hjic-87	14	15	.	.	PUNCT
hjic-87	15	1	in	in	ADP
hjic-87	15	2	certain	certain	ADJ
hjic-87	15	3	cases	case	NOUN
hjic-87	15	4	dry	dry	ADJ
hjic-87	15	5	powder	powder	NOUN
hjic-87	15	6	must	must	AUX
hjic-87	15	7	undergo	undergo	VERB
hjic-87	15	8	a	a	DET
hjic-87	15	9	micronisation	micronisation	NOUN
hjic-87	15	10	step	step	NOUN
hjic-87	15	11	–	–	PUNCT
hjic-87	15	12	usually	usually	ADV
hjic-87	15	13	by	by	ADP
hjic-87	15	14	milling	mill	VERB
hjic-87	15	15	–	–	PUNCT
hjic-87	15	16	to	to	PART
hjic-87	15	17	generate	generate	VERB
hjic-87	15	18	the	the	DET
hjic-87	15	19	required	require	VERB
hjic-87	15	20	particle	particle	NOUN
hjic-87	15	21	size	size	NOUN
hjic-87	15	22	and	and	CCONJ
hjic-87	15	23	size	size	NOUN
hjic-87	15	24	distribution	distribution	NOUN
hjic-87	15	25	.	.	PUNCT
hjic-87	16	1	micronization	micronization	NOUN
hjic-87	16	2	techniques	technique	NOUN
hjic-87	16	3	like	like	ADP
hjic-87	16	4	air	air	NOUN
hjic-87	16	5	jet	jet	NOUN
hjic-87	16	6	milling	milling	NOUN
hjic-87	16	7	have	have	VERB
hjic-87	16	8	several	several	ADJ
hjic-87	16	9	disadvantages	disadvantage	NOUN
hjic-87	16	10	(	(	PUNCT
hjic-87	16	11	cohesive	cohesive	ADJ
hjic-87	16	12	,	,	PUNCT
hjic-87	16	13	electrostatically	electrostatically	ADV
hjic-87	16	14	charged	charge	VERB
hjic-87	16	15	product	product	NOUN
hjic-87	16	16	with	with	ADP
hjic-87	16	17	occasional	occasional	ADJ
hjic-87	16	18	crystallographic	crystallographic	ADJ
hjic-87	16	19	defects	defect	NOUN
hjic-87	16	20	)	)	PUNCT
hjic-87	16	21	.	.	PUNCT
hjic-87	17	1	researches	research	NOUN
hjic-87	17	2	of	of	ADP
hjic-87	17	3	recent	recent	ADJ
hjic-87	17	4	years	year	NOUN
hjic-87	17	5	pointed	point	VERB
hjic-87	17	6	out	out	ADP
hjic-87	17	7	that	that	SCONJ
hjic-87	17	8	supercritical	supercritical	ADJ
hjic-87	17	9	fluid	fluid	NOUN
hjic-87	17	10	processes	process	NOUN
hjic-87	17	11	offer	offer	VERB
hjic-87	17	12	alternative	alternative	ADJ
hjic-87	17	13	single	single	ADJ
hjic-87	17	14	-	-	PUNCT
hjic-87	17	15	step	step	NOUN
hjic-87	17	16	methods	method	NOUN
hjic-87	17	17	to	to	PART
hjic-87	17	18	prepare	prepare	VERB
hjic-87	17	19	micronized	micronized	ADJ
hjic-87	17	20	dry	dry	ADJ
hjic-87	17	21	powder	powder	NOUN
hjic-87	17	22	of	of	ADP
hjic-87	17	23	apis	apis	NOUN
hjic-87	17	24	with	with	ADP
hjic-87	17	25	controllable	controllable	ADJ
hjic-87	17	26	physical	physical	ADJ
hjic-87	17	27	properties	property	NOUN
hjic-87	17	28	including	include	VERB
hjic-87	17	29	particle	particle	NOUN
hjic-87	17	30	size	size	NOUN
hjic-87	17	31	,	,	PUNCT
hjic-87	17	32	morphology	morphology	NOUN
hjic-87	17	33	,	,	PUNCT
hjic-87	17	34	crystallinity	crystallinity	NOUN
hjic-87	17	35	,	,	PUNCT
hjic-87	17	36	residual	residual	ADJ
hjic-87	17	37	solvent	solvent	NOUN
hjic-87	17	38	content	content	NOUN
hjic-87	17	39	,	,	PUNCT
hjic-87	17	40	etc	etc	X
hjic-87	18	1	[	[	X
hjic-87	18	2	1	1	NUM
hjic-87	18	3	]	]	PUNCT
hjic-87	18	4	.	.	PUNCT
hjic-87	19	1	42	42	NUM
hjic-87	19	2	coprecipitations	coprecipitation	NOUN
hjic-87	19	3	of	of	ADP
hjic-87	19	4	drug	drug	NOUN
hjic-87	19	5	-	-	PUNCT
hjic-87	19	6	excipient	excipient	NOUN
hjic-87	19	7	systems	system	NOUN
hjic-87	19	8	are	be	AUX
hjic-87	19	9	also	also	ADV
hjic-87	19	10	widely	widely	ADV
hjic-87	19	11	used	use	VERB
hjic-87	19	12	in	in	ADP
hjic-87	19	13	formulation	formulation	NOUN
hjic-87	19	14	of	of	ADP
hjic-87	19	15	poorly	poorly	ADJ
hjic-87	19	16	water	water	NOUN
hjic-87	19	17	soluble	soluble	ADJ
hjic-87	19	18	apis	apis	NOUN
hjic-87	19	19	[	[	X
hjic-87	19	20	2	2	NUM
hjic-87	19	21	]	]	PUNCT
hjic-87	19	22	.	.	PUNCT
hjic-87	20	1	the	the	DET
hjic-87	20	2	most	most	ADV
hjic-87	20	3	important	important	ADJ
hjic-87	20	4	methods	method	NOUN
hjic-87	20	5	of	of	ADP
hjic-87	20	6	drug	drug	NOUN
hjic-87	20	7	solubilization	solubilization	NOUN
hjic-87	20	8	are	be	AUX
hjic-87	20	9	(	(	PUNCT
hjic-87	20	10	1	1	X
hjic-87	20	11	)	)	PUNCT
hjic-87	20	12	formulation	formulation	NOUN
hjic-87	20	13	of	of	ADP
hjic-87	20	14	solid	solid	ADJ
hjic-87	20	15	dispersion	dispersion	NOUN
hjic-87	20	16	(	(	PUNCT
hjic-87	20	17	or	or	CCONJ
hjic-87	20	18	solid	solid	ADJ
hjic-87	20	19	solution	solution	NOUN
hjic-87	20	20	)	)	PUNCT
hjic-87	20	21	,	,	PUNCT
hjic-87	20	22	(	(	PUNCT
hjic-87	20	23	2	2	X
hjic-87	20	24	)	)	PUNCT
hjic-87	20	25	preparation	preparation	NOUN
hjic-87	20	26	of	of	ADP
hjic-87	20	27	surface	surface	NOUN
hjic-87	20	28	modified	modify	VERB
hjic-87	20	29	nano	nano	NOUN
hjic-87	20	30	and	and	CCONJ
hjic-87	20	31	microparticles	microparticle	NOUN
hjic-87	20	32	and	and	CCONJ
hjic-87	20	33	(	(	PUNCT
hjic-87	20	34	3	3	X
hjic-87	20	35	)	)	PUNCT
hjic-87	20	36	complexation	complexation	NOUN
hjic-87	20	37	of	of	ADP
hjic-87	20	38	api	api	NOUN
hjic-87	20	39	in	in	ADP
hjic-87	20	40	water	water	NOUN
hjic-87	20	41	soluble	soluble	ADJ
hjic-87	20	42	cyclodextrin	cyclodextrin	NOUN
hjic-87	20	43	derivates	derivate	NOUN
hjic-87	20	44	.	.	PUNCT
hjic-87	21	1	solid	solid	ADJ
hjic-87	21	2	dispersions	dispersion	NOUN
hjic-87	21	3	of	of	ADP
hjic-87	21	4	drug	drug	NOUN
hjic-87	21	5	-	-	PUNCT
hjic-87	21	6	excipient	excipient	NOUN
hjic-87	21	7	systems	system	NOUN
hjic-87	21	8	are	be	AUX
hjic-87	21	9	composites	composite	NOUN
hjic-87	21	10	containing	contain	VERB
hjic-87	21	11	nanosized	nanosized	ADJ
hjic-87	21	12	particles	particle	NOUN
hjic-87	21	13	of	of	ADP
hjic-87	21	14	crystalline	crystalline	NOUN
hjic-87	21	15	or	or	CCONJ
hjic-87	21	16	amorphous	amorphous	ADJ
hjic-87	21	17	api	api	NOUN
hjic-87	21	18	homogenously	homogenously	ADV
hjic-87	21	19	dispersed	disperse	VERB
hjic-87	21	20	in	in	ADP
hjic-87	21	21	the	the	DET
hjic-87	21	22	carrier	carrier	NOUN
hjic-87	21	23	particles	particle	NOUN
hjic-87	21	24	.	.	PUNCT
hjic-87	22	1	the	the	DET
hjic-87	22	2	solid	solid	ADJ
hjic-87	22	3	dispersion	dispersion	NOUN
hjic-87	22	4	that	that	PRON
hjic-87	22	5	contains	contain	VERB
hjic-87	22	6	api	api	NOUN
hjic-87	22	7	dispersed	disperse	VERB
hjic-87	22	8	on	on	ADP
hjic-87	22	9	molecular	molecular	ADJ
hjic-87	22	10	level	level	NOUN
hjic-87	22	11	is	be	AUX
hjic-87	22	12	referred	refer	VERB
hjic-87	22	13	to	to	ADP
hjic-87	22	14	as	as	ADP
hjic-87	22	15	solid	solid	ADJ
hjic-87	22	16	solution	solution	NOUN
hjic-87	22	17	.	.	PUNCT
hjic-87	23	1	formulations	formulation	NOUN
hjic-87	23	2	containing	contain	VERB
hjic-87	23	3	amorphous	amorphous	ADJ
hjic-87	23	4	forms	form	NOUN
hjic-87	23	5	are	be	AUX
hjic-87	23	6	generally	generally	ADV
hjic-87	23	7	more	more	ADV
hjic-87	23	8	soluble	soluble	ADJ
hjic-87	23	9	than	than	ADP
hjic-87	23	10	their	their	PRON
hjic-87	23	11	crystalline	crystalline	NOUN
hjic-87	23	12	counterparts	counterpart	NOUN
hjic-87	23	13	but	but	CCONJ
hjic-87	23	14	for	for	ADP
hjic-87	23	15	the	the	DET
hjic-87	23	16	same	same	ADJ
hjic-87	23	17	reason	reason	NOUN
hjic-87	23	18	they	they	PRON
hjic-87	23	19	are	be	AUX
hjic-87	23	20	less	less	ADV
hjic-87	23	21	stable	stable	ADJ
hjic-87	23	22	and	and	CCONJ
hjic-87	23	23	may	may	AUX
hjic-87	23	24	tend	tend	VERB
hjic-87	23	25	to	to	PART
hjic-87	23	26	crystallize	crystallize	VERB
hjic-87	23	27	during	during	ADP
hjic-87	23	28	the	the	DET
hjic-87	23	29	product	product	NOUN
hjic-87	23	30	shelf	shelf	NOUN
hjic-87	23	31	life	life	NOUN
hjic-87	23	32	.	.	PUNCT
hjic-87	24	1	these	these	DET
hjic-87	24	2	materials	material	NOUN
hjic-87	24	3	are	be	AUX
hjic-87	24	4	often	often	ADV
hjic-87	24	5	sensitive	sensitive	ADJ
hjic-87	24	6	to	to	ADP
hjic-87	24	7	water	water	NOUN
hjic-87	24	8	sorption	sorption	NOUN
hjic-87	24	9	,	,	PUNCT
hjic-87	24	10	mechanical	mechanical	ADJ
hjic-87	24	11	and	and	CCONJ
hjic-87	24	12	thermal	thermal	ADJ
hjic-87	24	13	stresses	stress	NOUN
hjic-87	24	14	.	.	PUNCT
hjic-87	25	1	surface	surface	NOUN
hjic-87	25	2	modification	modification	NOUN
hjic-87	25	3	techniques	technique	NOUN
hjic-87	25	4	aim	aim	VERB
hjic-87	25	5	to	to	PART
hjic-87	25	6	hide	hide	VERB
hjic-87	25	7	the	the	DET
hjic-87	25	8	hydrophobic	hydrophobic	ADJ
hjic-87	25	9	nature	nature	NOUN
hjic-87	25	10	of	of	ADP
hjic-87	25	11	the	the	DET
hjic-87	25	12	surface	surface	NOUN
hjic-87	25	13	of	of	ADP
hjic-87	25	14	drugparticles	drugparticle	NOUN
hjic-87	25	15	either	either	CCONJ
hjic-87	25	16	by	by	ADP
hjic-87	25	17	forming	form	VERB
hjic-87	25	18	an	an	DET
hjic-87	25	19	adsorbed	adsorb	VERB
hjic-87	25	20	layer	layer	NOUN
hjic-87	25	21	of	of	ADP
hjic-87	25	22	surfactants	surfactant	NOUN
hjic-87	25	23	or	or	CCONJ
hjic-87	25	24	by	by	ADP
hjic-87	25	25	coating	coat	VERB
hjic-87	25	26	with	with	ADP
hjic-87	25	27	hydrophilic	hydrophilic	ADJ
hjic-87	25	28	polymers	polymer	NOUN
hjic-87	25	29	.	.	PUNCT
hjic-87	26	1	this	this	DET
hjic-87	26	2	approach	approach	NOUN
hjic-87	26	3	requires	require	VERB
hjic-87	26	4	smaller	small	ADJ
hjic-87	26	5	amount	amount	NOUN
hjic-87	26	6	of	of	ADP
hjic-87	26	7	excipient	excipient	NOUN
hjic-87	26	8	compared	compare	VERB
hjic-87	26	9	to	to	ADP
hjic-87	26	10	solid	solid	ADJ
hjic-87	26	11	dispersion	dispersion	NOUN
hjic-87	26	12	[	[	X
hjic-87	26	13	3	3	NUM
hjic-87	26	14	]	]	PUNCT
hjic-87	26	15	.	.	PUNCT
hjic-87	27	1	the	the	DET
hjic-87	27	2	third	third	ADJ
hjic-87	27	3	method	method	NOUN
hjic-87	27	4	is	be	AUX
hjic-87	27	5	forming	form	VERB
hjic-87	27	6	inclusion	inclusion	NOUN
hjic-87	27	7	complexes	complex	NOUN
hjic-87	27	8	of	of	ADP
hjic-87	27	9	apis	apis	PROPN
hjic-87	27	10	and	and	CCONJ
hjic-87	27	11	water	water	NOUN
hjic-87	27	12	soluble	soluble	ADJ
hjic-87	27	13	cyclodextrin	cyclodextrin	NOUN
hjic-87	27	14	(	(	PUNCT
hjic-87	27	15	cd	cd	NOUN
hjic-87	27	16	)	)	PUNCT
hjic-87	27	17	derivates	derivate	NOUN
hjic-87	27	18	.	.	PUNCT
hjic-87	28	1	in	in	ADP
hjic-87	28	2	addition	addition	NOUN
hjic-87	28	3	to	to	ADP
hjic-87	28	4	conventional	conventional	ADJ
hjic-87	28	5	techniques	technique	NOUN
hjic-87	28	6	–	–	PUNCT
hjic-87	28	7	hot	hot	ADJ
hjic-87	28	8	melt	melt	NOUN
hjic-87	28	9	extrusion	extrusion	NOUN
hjic-87	28	10	,	,	PUNCT
hjic-87	28	11	spraydrying	spraydrying	NOUN
hjic-87	28	12	and	and	CCONJ
hjic-87	28	13	solvent	solvent	ADJ
hjic-87	28	14	evaporation	evaporation	NOUN
hjic-87	28	15	–	–	PUNCT
hjic-87	28	16	amorphous	amorphous	ADJ
hjic-87	28	17	composites	composite	NOUN
hjic-87	28	18	can	can	AUX
hjic-87	28	19	be	be	AUX
hjic-87	28	20	obtained	obtain	VERB
hjic-87	28	21	by	by	ADP
hjic-87	28	22	cryogenic	cryogenic	ADJ
hjic-87	28	23	formulation	formulation	NOUN
hjic-87	28	24	techniques	technique	NOUN
hjic-87	28	25	discussed	discuss	VERB
hjic-87	28	26	in	in	ADP
hjic-87	28	27	the	the	DET
hjic-87	28	28	second	second	ADJ
hjic-87	28	29	chapter	chapter	NOUN
hjic-87	28	30	.	.	PUNCT
hjic-87	29	1	coformulations	coformulation	NOUN
hjic-87	29	2	using	use	VERB
hjic-87	29	3	supercritical	supercritical	ADJ
hjic-87	29	4	fluids	fluid	NOUN
hjic-87	29	5	since	since	SCONJ
hjic-87	29	6	the	the	DET
hjic-87	29	7	first	first	ADJ
hjic-87	29	8	experiences	experience	NOUN
hjic-87	29	9	of	of	ADP
hjic-87	29	10	hannay	hannay	PROPN
hjic-87	29	11	et	et	PROPN
hjic-87	29	12	al	al	PROPN
hjic-87	29	13	.	.	PROPN
hjic-87	30	1	in	in	ADP
hjic-87	30	2	1879	1879	NUM
hjic-87	30	3	[	[	X
hjic-87	30	4	4	4	NUM
hjic-87	30	5	]	]	PUNCT
hjic-87	30	6	,	,	PUNCT
hjic-87	30	7	application	application	NOUN
hjic-87	30	8	of	of	ADP
hjic-87	30	9	dense	dense	ADJ
hjic-87	30	10	gases	gas	NOUN
hjic-87	30	11	in	in	ADP
hjic-87	30	12	crystallization	crystallization	NOUN
hjic-87	30	13	processes	process	NOUN
hjic-87	30	14	has	have	AUX
hjic-87	30	15	made	make	VERB
hjic-87	30	16	a	a	DET
hjic-87	30	17	long	long	ADJ
hjic-87	30	18	way	way	NOUN
hjic-87	31	1	[	[	X
hjic-87	31	2	1,5	1,5	NUM
hjic-87	31	3	]	]	PUNCT
hjic-87	31	4	.	.	PUNCT
hjic-87	32	1	this	this	DET
hjic-87	32	2	chapter	chapter	NOUN
hjic-87	32	3	reviews	review	VERB
hjic-87	32	4	the	the	DET
hjic-87	32	5	different	different	ADJ
hjic-87	32	6	techniques	technique	NOUN
hjic-87	32	7	published	publish	VERB
hjic-87	32	8	and	and	CCONJ
hjic-87	32	9	patented	patent	VERB
hjic-87	32	10	so	so	ADV
hjic-87	32	11	far	far	ADV
hjic-87	32	12	in	in	ADP
hjic-87	32	13	the	the	DET
hjic-87	32	14	field	field	NOUN
hjic-87	32	15	of	of	ADP
hjic-87	32	16	particle	particle	NOUN
hjic-87	32	17	design	design	NOUN
hjic-87	32	18	with	with	ADP
hjic-87	32	19	supercritical	supercritical	ADJ
hjic-87	32	20	fluids	fluid	NOUN
hjic-87	32	21	with	with	ADP
hjic-87	32	22	special	special	ADJ
hjic-87	32	23	regard	regard	NOUN
hjic-87	32	24	to	to	ADP
hjic-87	32	25	coprecipitation	coprecipitation	NOUN
hjic-87	32	26	of	of	ADP
hjic-87	32	27	active	active	ADJ
hjic-87	32	28	substrate	substrate	NOUN
hjic-87	32	29	-	-	PUNCT
hjic-87	32	30	carrier	carrier	NOUN
hjic-87	32	31	matrix	matrix	NOUN
hjic-87	32	32	composites	composite	NOUN
hjic-87	32	33	.	.	PUNCT
hjic-87	33	1	beside	beside	ADP
hjic-87	33	2	the	the	DET
hjic-87	33	3	most	most	ADV
hjic-87	33	4	important	important	ADJ
hjic-87	33	5	techniques	technique	NOUN
hjic-87	33	6	such	such	ADJ
hjic-87	33	7	as	as	ADP
hjic-87	33	8	the	the	DET
hjic-87	33	9	rapid	rapid	ADJ
hjic-87	33	10	expansion	expansion	NOUN
hjic-87	33	11	from	from	ADP
hjic-87	33	12	supercritical	supercritical	ADJ
hjic-87	33	13	solution	solution	NOUN
hjic-87	33	14	(	(	PUNCT
hjic-87	33	15	ress	ress	NOUN
hjic-87	33	16	)	)	PUNCT
hjic-87	33	17	,	,	PUNCT
hjic-87	33	18	particles	particle	NOUN
hjic-87	33	19	from	from	ADP
hjic-87	33	20	gas	gas	NOUN
hjic-87	33	21	-	-	PUNCT
hjic-87	33	22	saturated	saturate	VERB
hjic-87	33	23	solution	solution	NOUN
hjic-87	33	24	(	(	PUNCT
hjic-87	33	25	pgss	pgss	ADV
hjic-87	33	26	)	)	PUNCT
hjic-87	33	27	,	,	PUNCT
hjic-87	33	28	gas	gas	NOUN
hjic-87	33	29	antisolvent	antisolvent	NOUN
hjic-87	33	30	(	(	PUNCT
hjic-87	33	31	gas	gas	NOUN
hjic-87	33	32	)	)	PUNCT
hjic-87	33	33	,	,	PUNCT
hjic-87	33	34	supercritical	supercritical	ADJ
hjic-87	33	35	antisolvent	antisolvent	NOUN
hjic-87	33	36	(	(	PUNCT
hjic-87	33	37	sas	sas	PROPN
hjic-87	33	38	)	)	PUNCT
hjic-87	33	39	,	,	PUNCT
hjic-87	33	40	solution	solution	NOUN
hjic-87	33	41	enhanced	enhance	VERB
hjic-87	33	42	dispersion	dispersion	NOUN
hjic-87	33	43	by	by	ADP
hjic-87	33	44	supercritical	supercritical	ADJ
hjic-87	33	45	fluids	fluid	NOUN
hjic-87	33	46	(	(	PUNCT
hjic-87	33	47	seds	sed	NOUN
hjic-87	33	48	)	)	PUNCT
hjic-87	33	49	,	,	PUNCT
hjic-87	33	50	precipitation	precipitation	NOUN
hjic-87	33	51	with	with	ADP
hjic-87	33	52	a	a	DET
hjic-87	33	53	compressed	compress	VERB
hjic-87	33	54	fluid	fluid	ADJ
hjic-87	33	55	antisolvent	antisolvent	NOUN
hjic-87	33	56	(	(	PUNCT
hjic-87	33	57	pca	pca	PROPN
hjic-87	33	58	)	)	PUNCT
hjic-87	33	59	and	and	CCONJ
hjic-87	33	60	the	the	DET
hjic-87	33	61	aerosol	aerosol	NOUN
hjic-87	33	62	solvent	solvent	NOUN
hjic-87	33	63	extraction	extraction	NOUN
hjic-87	33	64	system	system	NOUN
hjic-87	33	65	(	(	PUNCT
hjic-87	33	66	ases	ases	PROPN
hjic-87	33	67	)	)	PUNCT
hjic-87	33	68	,	,	PUNCT
hjic-87	33	69	some	some	DET
hjic-87	33	70	other	other	ADJ
hjic-87	33	71	less	less	ADV
hjic-87	33	72	known	know	VERB
hjic-87	33	73	methods	method	NOUN
hjic-87	33	74	were	be	AUX
hjic-87	33	75	as	as	ADV
hjic-87	33	76	well	well	ADV
hjic-87	33	77	discussed	discuss	VERB
hjic-87	33	78	like	like	ADP
hjic-87	33	79	rapid	rapid	ADJ
hjic-87	33	80	expansion	expansion	NOUN
hjic-87	33	81	from	from	ADP
hjic-87	33	82	supercritical	supercritical	ADJ
hjic-87	33	83	solution	solution	NOUN
hjic-87	33	84	with	with	ADP
hjic-87	33	85	a	a	DET
hjic-87	33	86	non	non	ADJ
hjic-87	33	87	-	-	ADJ
hjic-87	33	88	solvent	solvent	ADJ
hjic-87	33	89	(	(	PUNCT
hjic-87	33	90	ressn	ressn	NOUN
hjic-87	33	91	)	)	PUNCT
hjic-87	33	92	,	,	PUNCT
hjic-87	33	93	rapid	rapid	ADJ
hjic-87	33	94	expansion	expansion	NOUN
hjic-87	33	95	from	from	ADP
hjic-87	33	96	supercritical	supercritical	ADJ
hjic-87	33	97	to	to	ADP
hjic-87	33	98	aqueous	aqueous	ADJ
hjic-87	33	99	solution	solution	NOUN
hjic-87	33	100	(	(	PUNCT
hjic-87	33	101	resas	resas	NOUN
hjic-87	33	102	)	)	PUNCT
hjic-87	33	103	,	,	PUNCT
hjic-87	33	104	rapid	rapid	ADJ
hjic-87	33	105	expansion	expansion	NOUN
hjic-87	33	106	of	of	ADP
hjic-87	33	107	liquefied	liquefy	VERB
hjic-87	33	108	gas	gas	NOUN
hjic-87	33	109	solution	solution	NOUN
hjic-87	33	110	(	(	PUNCT
hjic-87	33	111	relgs	relgs	NOUN
hjic-87	33	112	)	)	PUNCT
hjic-87	33	113	,	,	PUNCT
hjic-87	33	114	rapid	rapid	ADJ
hjic-87	33	115	expansion	expansion	NOUN
hjic-87	33	116	of	of	ADP
hjic-87	33	117	liquefied	liquefy	VERB
hjic-87	33	118	-	-	PUNCT
hjic-87	33	119	gas	gas	NOUN
hjic-87	33	120	solution	solution	NOUN
hjic-87	33	121	and	and	CCONJ
hjic-87	33	122	homogenization	homogenization	NOUN
hjic-87	33	123	(	(	PUNCT
hjic-87	33	124	relgs	relgs	NOUN
hjic-87	33	125	-	-	PUNCT
hjic-87	33	126	h	h	NOUN
hjic-87	33	127	)	)	PUNCT
hjic-87	33	128	and	and	CCONJ
hjic-87	33	129	polymer	polymer	NOUN
hjic-87	33	130	liquefaction	liquefaction	NOUN
hjic-87	33	131	using	use	VERB
hjic-87	33	132	supercritical	supercritical	ADJ
hjic-87	33	133	solvating	solvating	NOUN
hjic-87	33	134	(	(	PUNCT
hjic-87	33	135	pluss	pluss	ADJ
hjic-87	33	136	)	)	PUNCT
hjic-87	33	137	(	(	PUNCT
hjic-87	33	138	see	see	VERB
hjic-87	33	139	fig	fig	NOUN
hjic-87	33	140	.	.	PUNCT
hjic-87	34	1	1	1	NUM
hjic-87	34	2	)	)	PUNCT
hjic-87	34	3	.	.	PUNCT
hjic-87	35	1	these	these	DET
hjic-87	35	2	methods	method	NOUN
hjic-87	35	3	use	use	VERB
hjic-87	35	4	supercritical	supercritical	ADJ
hjic-87	35	5	fluids	fluid	NOUN
hjic-87	35	6	(	(	PUNCT
hjic-87	35	7	scf	scf	PROPN
hjic-87	35	8	)	)	PUNCT
hjic-87	35	9	either	either	CCONJ
hjic-87	35	10	as	as	ADP
hjic-87	35	11	solvent	solvent	NOUN
hjic-87	35	12	(	(	PUNCT
hjic-87	35	13	ress	ress	NOUN
hjic-87	35	14	)	)	PUNCT
hjic-87	35	15	or	or	CCONJ
hjic-87	35	16	antisolvent	antisolvent	NOUN
hjic-87	35	17	(	(	PUNCT
hjic-87	35	18	gas	gas	NOUN
hjic-87	35	19	,	,	PUNCT
hjic-87	35	20	sas	sas	PROPN
hjic-87	35	21	,	,	PUNCT
hjic-87	35	22	ases	as	NOUN
hjic-87	35	23	,	,	PUNCT
hjic-87	35	24	seds	sed	NOUN
hjic-87	35	25	)	)	PUNCT
hjic-87	35	26	and/or	and/or	CCONJ
hjic-87	35	27	dispersing	disperse	VERB
hjic-87	35	28	fluid	fluid	NOUN
hjic-87	35	29	(	(	PUNCT
hjic-87	35	30	gas	gas	NOUN
hjic-87	35	31	,	,	PUNCT
hjic-87	35	32	seds	sed	NOUN
hjic-87	35	33	,	,	PUNCT
hjic-87	35	34	pgss	pgss	ADJ
hjic-87	35	35	)	)	PUNCT
hjic-87	35	36	.	.	PUNCT
hjic-87	36	1	as	as	SCONJ
hjic-87	36	2	applied	apply	VERB
hjic-87	36	3	scfs	scfs	NOUN
hjic-87	36	4	(	(	PUNCT
hjic-87	36	5	usually	usually	ADV
hjic-87	36	6	co2	co2	NOUN
hjic-87	36	7	)	)	PUNCT
hjic-87	36	8	are	be	AUX
hjic-87	36	9	gases	gas	NOUN
hjic-87	36	10	at	at	ADP
hjic-87	36	11	ambient	ambient	ADJ
hjic-87	36	12	temperature	temperature	NOUN
hjic-87	36	13	and	and	CCONJ
hjic-87	36	14	pressure	pressure	NOUN
hjic-87	36	15	,	,	PUNCT
hjic-87	36	16	they	they	PRON
hjic-87	36	17	are	be	AUX
hjic-87	36	18	easy	easy	ADJ
hjic-87	36	19	to	to	PART
hjic-87	36	20	separate	separate	VERB
hjic-87	36	21	from	from	ADP
hjic-87	36	22	both	both	PRON
hjic-87	36	23	organic	organic	ADJ
hjic-87	36	24	cosolvent	cosolvent	ADJ
hjic-87	36	25	and	and	CCONJ
hjic-87	36	26	solid	solid	ADJ
hjic-87	36	27	product	product	NOUN
hjic-87	36	28	,	,	PUNCT
hjic-87	36	29	therefor	therefor	ADP
hjic-87	36	30	supercritical	supercritical	ADJ
hjic-87	36	31	technology	technology	NOUN
hjic-87	36	32	is	be	AUX
hjic-87	36	33	considered	consider	VERB
hjic-87	36	34	as	as	ADP
hjic-87	36	35	clean	clean	ADJ
hjic-87	36	36	,	,	PUNCT
hjic-87	36	37	recyclable	recyclable	ADJ
hjic-87	36	38	and	and	CCONJ
hjic-87	36	39	“	"	PUNCT
hjic-87	36	40	green	green	ADJ
hjic-87	36	41	”	"	PUNCT
hjic-87	36	42	technology	technology	NOUN
hjic-87	36	43	.	.	PUNCT
hjic-87	37	1	in	in	ADP
hjic-87	37	2	addition	addition	NOUN
hjic-87	37	3	,	,	PUNCT
hjic-87	37	4	carbon	carbon	NOUN
hjic-87	37	5	dioxide	dioxide	NOUN
hjic-87	37	6	–	–	PUNCT
hjic-87	37	7	the	the	DET
hjic-87	37	8	most	most	ADV
hjic-87	37	9	commonly	commonly	ADV
hjic-87	37	10	used	use	VERB
hjic-87	37	11	fluid	fluid	NOUN
hjic-87	37	12	–	–	PUNCT
hjic-87	37	13	is	be	AUX
hjic-87	37	14	chemically	chemically	ADV
hjic-87	37	15	inert	inert	ADJ
hjic-87	37	16	,	,	PUNCT
hjic-87	37	17	nontoxic	nontoxic	ADJ
hjic-87	37	18	,	,	PUNCT
hjic-87	37	19	non	non	ADJ
hjic-87	37	20	-	-	ADJ
hjic-87	37	21	flammable	flammable	ADJ
hjic-87	37	22	and	and	CCONJ
hjic-87	37	23	inexpensive	inexpensive	ADJ
hjic-87	37	24	.	.	PUNCT
hjic-87	38	1	having	have	VERB
hjic-87	38	2	mild	mild	ADJ
hjic-87	38	3	critical	critical	ADJ
hjic-87	38	4	temperature	temperature	NOUN
hjic-87	38	5	(	(	PUNCT
hjic-87	38	6	31,1	31,1	NOUN
hjic-87	38	7	°	°	NOUN
hjic-87	38	8	c	c	NOUN
hjic-87	38	9	)	)	PUNCT
hjic-87	38	10	and	and	CCONJ
hjic-87	38	11	a	a	DET
hjic-87	38	12	critical	critical	ADJ
hjic-87	38	13	pressure	pressure	NOUN
hjic-87	38	14	of	of	ADP
hjic-87	38	15	73,8	73,8	NUM
hjic-87	38	16	bar	bar	NOUN
hjic-87	38	17	,	,	PUNCT
hjic-87	38	18	co2	co2	NOUN
hjic-87	38	19	is	be	AUX
hjic-87	38	20	suitable	suitable	ADJ
hjic-87	38	21	to	to	PART
hjic-87	38	22	treat	treat	VERB
hjic-87	38	23	heat	heat	NOUN
hjic-87	38	24	-	-	PUNCT
hjic-87	38	25	sensitive	sensitive	ADJ
hjic-87	38	26	materials	material	NOUN
hjic-87	38	27	–	–	PUNCT
hjic-87	38	28	even	even	ADV
hjic-87	38	29	explosives	explosive	NOUN
hjic-87	38	30	–	–	PUNCT
hjic-87	38	31	without	without	ADP
hjic-87	38	32	any	any	DET
hjic-87	38	33	thermal	thermal	ADJ
hjic-87	38	34	degradation	degradation	NOUN
hjic-87	38	35	with	with	ADP
hjic-87	38	36	relatively	relatively	ADV
hjic-87	38	37	low	low	ADJ
hjic-87	38	38	energy	energy	NOUN
hjic-87	38	39	costs	cost	NOUN
hjic-87	38	40	.	.	PUNCT
hjic-87	39	1	rapid	rapid	ADJ
hjic-87	39	2	expansion	expansion	NOUN
hjic-87	39	3	of	of	ADP
hjic-87	39	4	supercritical	supercritical	ADJ
hjic-87	39	5	solution	solution	NOUN
hjic-87	39	6	(	(	PUNCT
hjic-87	39	7	ress	ress	PROPN
hjic-87	39	8	)	)	PUNCT
hjic-87	39	9	ress	ress	NOUN
hjic-87	39	10	consists	consist	VERB
hjic-87	39	11	in	in	ADP
hjic-87	39	12	depressurising	depressurise	VERB
hjic-87	39	13	the	the	DET
hjic-87	39	14	solution	solution	NOUN
hjic-87	39	15	of	of	ADP
hjic-87	39	16	the	the	DET
hjic-87	39	17	solid	solid	ADJ
hjic-87	39	18	substrate	substrate	NOUN
hjic-87	39	19	solvated	solvate	VERB
hjic-87	39	20	in	in	ADP
hjic-87	39	21	supercritical	supercritical	ADJ
hjic-87	39	22	fluid	fluid	NOUN
hjic-87	39	23	through	through	ADP
hjic-87	39	24	a	a	DET
hjic-87	39	25	heated	heated	ADJ
hjic-87	39	26	nozzle	nozzle	NOUN
hjic-87	39	27	(	(	PUNCT
hjic-87	39	28	10	10	NUM
hjic-87	39	29	-	-	SYM
hjic-87	39	30	50	50	NUM
hjic-87	39	31	µm	µm	NOUN
hjic-87	39	32	,	,	PUNCT
hjic-87	39	33	i.d	i.d	PROPN
hjic-87	39	34	.	.	PROPN
hjic-87	39	35	)	)	PUNCT
hjic-87	39	36	,	,	PUNCT
hjic-87	39	37	causing	cause	VERB
hjic-87	39	38	an	an	DET
hjic-87	39	39	extremely	extremely	ADV
hjic-87	39	40	rapid	rapid	ADJ
hjic-87	39	41	nucleation	nucleation	NOUN
hjic-87	39	42	of	of	ADP
hjic-87	39	43	the	the	DET
hjic-87	39	44	substrat	substrat	NOUN
hjic-87	39	45	in	in	ADP
hjic-87	39	46	question	question	NOUN
hjic-87	39	47	[	[	X
hjic-87	39	48	4	4	NUM
hjic-87	39	49	]	]	PUNCT
hjic-87	39	50	.	.	PUNCT
hjic-87	40	1	this	this	DET
hjic-87	40	2	process	process	NOUN
hjic-87	40	3	is	be	AUX
hjic-87	40	4	attractive	attractive	ADJ
hjic-87	40	5	due	due	ADP
hjic-87	40	6	to	to	ADP
hjic-87	40	7	the	the	DET
hjic-87	40	8	absence	absence	NOUN
hjic-87	40	9	of	of	ADP
hjic-87	40	10	organic	organic	ADJ
hjic-87	40	11	solvent	solvent	NOUN
hjic-87	40	12	,	,	PUNCT
hjic-87	40	13	but	but	CCONJ
hjic-87	40	14	efficiency	efficiency	NOUN
hjic-87	40	15	and/or	and/or	CCONJ
hjic-87	40	16	feasibility	feasibility	NOUN
hjic-87	40	17	depends	depend	VERB
hjic-87	40	18	on	on	ADP
hjic-87	40	19	the	the	DET
hjic-87	40	20	solubility	solubility	NOUN
hjic-87	40	21	of	of	ADP
hjic-87	40	22	the	the	DET
hjic-87	40	23	treated	treat	VERB
hjic-87	40	24	substrate	substrate	NOUN
hjic-87	40	25	in	in	ADP
hjic-87	40	26	scf	scf	PROPN
hjic-87	40	27	at	at	ADP
hjic-87	40	28	the	the	DET
hjic-87	40	29	operating	operate	VERB
hjic-87	40	30	temperature	temperature	NOUN
hjic-87	40	31	and	and	CCONJ
hjic-87	40	32	pressure	pressure	NOUN
hjic-87	40	33	.	.	PUNCT
hjic-87	41	1	to	to	PART
hjic-87	41	2	overcome	overcome	VERB
hjic-87	41	3	the	the	DET
hjic-87	41	4	difficulties	difficulty	NOUN
hjic-87	41	5	associated	associate	VERB
hjic-87	41	6	with	with	ADP
hjic-87	41	7	scco2	scco2	ADJ
hjic-87	41	8	-	-	PUNCT
hjic-87	41	9	insoluble	insoluble	ADJ
hjic-87	41	10	polar	polar	ADJ
hjic-87	41	11	compounds	compound	NOUN
hjic-87	41	12	and	and	CCONJ
hjic-87	41	13	high	high	ADJ
hjic-87	41	14	molecular	molecular	ADJ
hjic-87	41	15	weight	weight	NOUN
hjic-87	41	16	polymers	polymer	NOUN
hjic-87	41	17	,	,	PUNCT
hjic-87	41	18	mishima	mishima	PROPN
hjic-87	41	19	et	et	PROPN
hjic-87	41	20	al	al	PROPN
hjic-87	41	21	.	.	PROPN
hjic-87	41	22	have	have	AUX
hjic-87	41	23	invented	invent	VERB
hjic-87	41	24	a	a	DET
hjic-87	41	25	new	new	ADJ
hjic-87	41	26	method	method	NOUN
hjic-87	41	27	called	call	VERB
hjic-87	41	28	rapid	rapid	ADJ
hjic-87	41	29	expansion	expansion	NOUN
hjic-87	41	30	from	from	ADP
hjic-87	41	31	supercritical	supercritical	ADJ
hjic-87	41	32	solution	solution	NOUN
hjic-87	41	33	with	with	ADP
hjic-87	41	34	a	a	DET
hjic-87	41	35	non	non	ADJ
hjic-87	41	36	-	-	NOUN
hjic-87	41	37	solvent	solvent	ADJ
hjic-87	41	38	(	(	PUNCT
hjic-87	41	39	ress	ress	NOUN
hjic-87	41	40	-	-	PUNCT
hjic-87	41	41	n	n	CCONJ
hjic-87	41	42	)	)	PUNCT
hjic-87	41	43	.	.	PUNCT
hjic-87	42	1	this	this	DET
hjic-87	42	2	process	process	NOUN
hjic-87	42	3	involves	involve	VERB
hjic-87	42	4	a	a	DET
hjic-87	42	5	second	second	ADJ
hjic-87	42	6	solvent	solvent	NOUN
hjic-87	42	7	which	which	PRON
hjic-87	42	8	solubilizes	solubilize	VERB
hjic-87	42	9	the	the	DET
hjic-87	42	10	solid	solid	ADJ
hjic-87	42	11	substrates	substrate	NOUN
hjic-87	42	12	in	in	ADP
hjic-87	42	13	supercritical	supercritical	ADJ
hjic-87	42	14	conditions	condition	NOUN
hjic-87	42	15	but	but	CCONJ
hjic-87	42	16	does	do	AUX
hjic-87	42	17	n’t	not	PART
hjic-87	42	18	dissolve	dissolve	VERB
hjic-87	42	19	them	they	PRON
hjic-87	42	20	at	at	ADP
hjic-87	42	21	atmospheric	atmospheric	ADJ
hjic-87	42	22	pressure	pressure	NOUN
hjic-87	42	23	.	.	PUNCT
hjic-87	43	1	this	this	DET
hjic-87	43	2	cosolvent	cosolvent	NOUN
hjic-87	43	3	is	be	AUX
hjic-87	43	4	homogenized	homogenize	VERB
hjic-87	43	5	in	in	ADP
hjic-87	43	6	the	the	DET
hjic-87	43	7	pure	pure	ADJ
hjic-87	43	8	scf	scf	PROPN
hjic-87	43	9	before	before	ADP
hjic-87	43	10	the	the	DET
hjic-87	43	11	extraxtion	extraxtion	NOUN
hjic-87	43	12	unit	unit	NOUN
hjic-87	43	13	,	,	PUNCT
hjic-87	43	14	the	the	DET
hjic-87	43	15	modified	modify	VERB
hjic-87	43	16	scf	scf	PROPN
hjic-87	43	17	is	be	AUX
hjic-87	43	18	saturated	saturate	VERB
hjic-87	43	19	in	in	ADP
hjic-87	43	20	the	the	DET
hjic-87	43	21	solid	solid	ADJ
hjic-87	43	22	substrates	substrate	NOUN
hjic-87	43	23	and	and	CCONJ
hjic-87	43	24	expanded	expand	VERB
hjic-87	43	25	through	through	ADP
hjic-87	43	26	a	a	DET
hjic-87	43	27	nozzle	nozzle	NOUN
hjic-87	43	28	to	to	ADP
hjic-87	43	29	atmospheric	atmospheric	ADJ
hjic-87	43	30	pressure	pressure	NOUN
hjic-87	43	31	[	[	X
hjic-87	43	32	6	6	NUM
hjic-87	43	33	]	]	PUNCT
hjic-87	43	34	.	.	PUNCT
hjic-87	44	1	this	this	DET
hjic-87	44	2	method	method	NOUN
hjic-87	44	3	was	be	AUX
hjic-87	44	4	afterwards	afterwards	ADV
hjic-87	44	5	used	use	VERB
hjic-87	44	6	for	for	ADP
hjic-87	44	7	encapsulation	encapsulation	NOUN
hjic-87	44	8	of	of	ADP
hjic-87	44	9	proteins	protein	NOUN
hjic-87	44	10	(	(	PUNCT
hjic-87	44	11	lysozyme	lysozyme	NOUN
hjic-87	44	12	,	,	PUNCT
hjic-87	44	13	lipase	lipase	NOUN
hjic-87	44	14	)	)	PUNCT
hjic-87	44	15	as	as	ADV
hjic-87	44	16	well	well	ADV
hjic-87	44	17	as	as	ADP
hjic-87	44	18	flavone	flavone	NOUN
hjic-87	44	19	and	and	CCONJ
hjic-87	44	20	3	3	NUM
hjic-87	44	21	-	-	NOUN
hjic-87	44	22	hdroxyflavone	hdroxyflavone	NOUN
hjic-87	44	23	in	in	ADP
hjic-87	44	24	biodegradable	biodegradable	ADJ
hjic-87	44	25	polymers	polymer	NOUN
hjic-87	44	26	like	like	ADP
hjic-87	44	27	:	:	PUNCT
hjic-87	44	28	polyethylene	polyethylene	NOUN
hjic-87	44	29	glycol	glycol	NOUN
hjic-87	44	30	(	(	PUNCT
hjic-87	44	31	peg	peg	NOUN
hjic-87	44	32	)	)	PUNCT
hjic-87	44	33	,	,	PUNCT
hjic-87	44	34	poly(methyl	poly(methyl	PROPN
hjic-87	44	35	methacrilate	methacrilate	VERB
hjic-87	44	36	)	)	PUNCT
hjic-87	44	37	(	(	PUNCT
hjic-87	44	38	pmma	pmma	PROPN
hjic-87	44	39	)	)	PUNCT
hjic-87	44	40	,	,	PUNCT
hjic-87	44	41	poly(lactic	poly(lactic	ADJ
hjic-87	44	42	acid	acid	NOUN
hjic-87	44	43	)	)	PUNCT
hjic-87	44	44	(	(	PUNCT
hjic-87	44	45	pla	pla	NOUN
hjic-87	44	46	)	)	PUNCT
hjic-87	44	47	,	,	PUNCT
hjic-87	44	48	poly(lactic	poly(lactic	PROPN
hjic-87	44	49	-	-	PUNCT
hjic-87	44	50	co	co	NOUN
hjic-87	44	51	-	-	ADJ
hjic-87	44	52	glycolic	glycolic	ADJ
hjic-87	44	53	acid	acid	NOUN
hjic-87	44	54	)	)	PUNCT
hjic-87	44	55	(	(	PUNCT
hjic-87	44	56	plga	plga	NOUN
hjic-87	44	57	)	)	PUNCT
hjic-87	44	58	;	;	PUNCT
hjic-87	44	59	poloxamer	poloxamer	NOUN
hjic-87	44	60	and	and	CCONJ
hjic-87	44	61	eudragit	eudragit	VERB
hjic-87	44	62	e100	e100	PROPN
hjic-87	45	1	[	[	X
hjic-87	45	2	7	7	NUM
hjic-87	45	3	-	-	SYM
hjic-87	45	4	9	9	NUM
hjic-87	45	5	]	]	PUNCT
hjic-87	45	6	.	.	PUNCT
hjic-87	46	1	the	the	DET
hjic-87	46	2	concentrations	concentration	NOUN
hjic-87	46	3	of	of	ADP
hjic-87	46	4	cosolvents	cosolvent	NOUN
hjic-87	46	5	must	must	AUX
hjic-87	46	6	be	be	AUX
hjic-87	46	7	at	at	ADV
hjic-87	46	8	least	least	ADV
hjic-87	46	9	27	27	NUM
hjic-87	46	10	%	%	NOUN
hjic-87	46	11	(	(	PUNCT
hjic-87	46	12	w	w	NOUN
hjic-87	46	13	/	/	SYM
hjic-87	46	14	w	w	NOUN
hjic-87	46	15	)	)	PUNCT
hjic-87	46	16	to	to	PART
hjic-87	46	17	achieve	achieve	VERB
hjic-87	46	18	enough	enough	ADJ
hjic-87	46	19	high	high	ADJ
hjic-87	46	20	solubility	solubility	NOUN
hjic-87	46	21	of	of	ADP
hjic-87	46	22	polymer	polymer	NOUN
hjic-87	46	23	in	in	ADP
hjic-87	46	24	scco2	scco2	ADJ
hjic-87	46	25	/	/	SYM
hjic-87	46	26	cosolvent	cosolvent	ADJ
hjic-87	46	27	system	system	NOUN
hjic-87	46	28	and	and	CCONJ
hjic-87	46	29	the	the	DET
hjic-87	46	30	active	active	ADJ
hjic-87	46	31	principle	principle	NOUN
hjic-87	46	32	must	must	AUX
hjic-87	46	33	be	be	AUX
hjic-87	46	34	insoluble	insoluble	ADJ
hjic-87	46	35	in	in	ADP
hjic-87	46	36	the	the	DET
hjic-87	46	37	chosen	choose	VERB
hjic-87	46	38	cosolvent	cosolvent	NOUN
hjic-87	46	39	.	.	PUNCT
hjic-87	47	1	43	43	NUM
hjic-87	47	2	in	in	ADP
hjic-87	47	3	1994	1994	NUM
hjic-87	47	4	,	,	PUNCT
hjic-87	47	5	frederiksen	frederiksen	PROPN
hjic-87	47	6	et	et	PROPN
hjic-87	47	7	al	al	PROPN
hjic-87	47	8	.	.	PROPN
hjic-87	47	9	patented	patent	VERB
hjic-87	47	10	a	a	DET
hjic-87	47	11	method	method	NOUN
hjic-87	47	12	suitable	suitable	ADJ
hjic-87	47	13	to	to	PART
hjic-87	47	14	prepare	prepare	VERB
hjic-87	47	15	liposomes	liposome	NOUN
hjic-87	47	16	containing	contain	VERB
hjic-87	47	17	at	at	ADV
hjic-87	47	18	least	least	ADV
hjic-87	47	19	one	one	NUM
hjic-87	47	20	phospholipid	phospholipid	NOUN
hjic-87	47	21	,	,	PUNCT
hjic-87	47	22	an	an	DET
hjic-87	47	23	excipient	excipient	NOUN
hjic-87	47	24	and	and	CCONJ
hjic-87	47	25	a	a	DET
hjic-87	47	26	water	water	NOUN
hjic-87	47	27	soluble	soluble	ADJ
hjic-87	47	28	api	api	NOUN
hjic-87	48	1	[	[	X
hjic-87	48	2	10,11	10,11	NOUN
hjic-87	48	3	]	]	PUNCT
hjic-87	48	4	.	.	PUNCT
hjic-87	49	1	phospholipids	phospholipid	NOUN
hjic-87	49	2	and	and	CCONJ
hjic-87	49	3	excipients	excipient	NOUN
hjic-87	49	4	were	be	AUX
hjic-87	49	5	dissolved	dissolve	VERB
hjic-87	49	6	in	in	ADP
hjic-87	49	7	an	an	DET
hjic-87	49	8	appropriate	appropriate	ADJ
hjic-87	49	9	polar	polar	ADJ
hjic-87	49	10	solvent	solvent	NOUN
hjic-87	49	11	and	and	CCONJ
hjic-87	49	12	homogenized	homogenize	VERB
hjic-87	49	13	in	in	ADP
hjic-87	49	14	scco2	scco2	NOUN
hjic-87	49	15	,	,	PUNCT
hjic-87	49	16	this	this	DET
hjic-87	49	17	solution	solution	NOUN
hjic-87	49	18	was	be	AUX
hjic-87	49	19	afterwards	afterwards	ADV
hjic-87	49	20	expanded	expand	VERB
hjic-87	49	21	to	to	ADP
hjic-87	49	22	atmospheric	atmospheric	ADJ
hjic-87	49	23	pressure	pressure	NOUN
hjic-87	49	24	and	and	CCONJ
hjic-87	49	25	simultaneously	simultaneously	ADV
hjic-87	49	26	dispersed	disperse	VERB
hjic-87	49	27	in	in	ADP
hjic-87	49	28	the	the	DET
hjic-87	49	29	aqueous	aqueous	ADJ
hjic-87	49	30	solution	solution	NOUN
hjic-87	49	31	of	of	ADP
hjic-87	49	32	api	api	NOUN
hjic-87	49	33	.	.	PUNCT
hjic-87	50	1	residual	residual	ADJ
hjic-87	50	2	organic	organic	ADJ
hjic-87	50	3	solvent	solvent	NOUN
hjic-87	50	4	can	can	AUX
hjic-87	50	5	be	be	AUX
hjic-87	50	6	removed	remove	VERB
hjic-87	50	7	by	by	ADP
hjic-87	50	8	evaporation	evaporation	NOUN
hjic-87	50	9	,	,	PUNCT
hjic-87	50	10	dialysis	dialysis	NOUN
hjic-87	50	11	or	or	CCONJ
hjic-87	50	12	gel	gel	NOUN
hjic-87	50	13	filtration	filtration	NOUN
hjic-87	50	14	.	.	PUNCT
hjic-87	51	1	five	five	NUM
hjic-87	51	2	years	year	NOUN
hjic-87	51	3	later	later	ADV
hjic-87	51	4	,	,	PUNCT
hjic-87	51	5	ma	ma	PROPN
hjic-87	51	6	shuxian	shuxian	PROPN
hjic-87	51	7	patented	patent	VERB
hjic-87	51	8	another	another	DET
hjic-87	51	9	process	process	NOUN
hjic-87	51	10	for	for	ADP
hjic-87	51	11	preparation	preparation	NOUN
hjic-87	51	12	of	of	ADP
hjic-87	51	13	liposomes	liposome	NOUN
hjic-87	51	14	by	by	ADP
hjic-87	51	15	(	(	PUNCT
hjic-87	51	16	1	1	X
hjic-87	51	17	)	)	PUNCT
hjic-87	51	18	dissolving	dissolve	VERB
hjic-87	51	19	a	a	DET
hjic-87	51	20	phospholipid	phospholipid	NOUN
hjic-87	51	21	,	,	PUNCT
hjic-87	51	22	an	an	DET
hjic-87	51	23	excipient	excipient	NOUN
hjic-87	51	24	and	and	CCONJ
hjic-87	51	25	a	a	DET
hjic-87	51	26	lipophilic	lipophilic	ADJ
hjic-87	51	27	api	api	NOUN
hjic-87	51	28	in	in	ADP
hjic-87	51	29	compressed	compressed	ADJ
hjic-87	51	30	or	or	CCONJ
hjic-87	51	31	supercritical	supercritical	ADJ
hjic-87	51	32	co2	co2	NOUN
hjic-87	51	33	(	(	PUNCT
hjic-87	51	34	2	2	X
hjic-87	51	35	)	)	PUNCT
hjic-87	51	36	releasing	release	VERB
hjic-87	51	37	the	the	DET
hjic-87	51	38	co2	co2	NOUN
hjic-87	51	39	until	until	SCONJ
hjic-87	51	40	the	the	DET
hjic-87	51	41	density	density	NOUN
hjic-87	51	42	of	of	ADP
hjic-87	51	43	co2	co2	NOUN
hjic-87	51	44	is	be	AUX
hjic-87	51	45	lower	low	ADJ
hjic-87	51	46	than	than	ADP
hjic-87	51	47	that	that	PRON
hjic-87	51	48	of	of	ADP
hjic-87	51	49	lipophilic	lipophilic	ADJ
hjic-87	51	50	api	api	NOUN
hjic-87	51	51	(	(	PUNCT
hjic-87	51	52	3	3	X
hjic-87	51	53	)	)	PUNCT
hjic-87	51	54	quickly	quickly	ADV
hjic-87	51	55	depressurizing	depressurize	VERB
hjic-87	51	56	the	the	DET
hjic-87	51	57	vessel	vessel	NOUN
hjic-87	51	58	(	(	PUNCT
hjic-87	51	59	4	4	X
hjic-87	51	60	)	)	PUNCT
hjic-87	51	61	loading	load	VERB
hjic-87	51	62	a	a	DET
hjic-87	51	63	dispersing	dispersing	NOUN
hjic-87	51	64	liquid	liquid	NOUN
hjic-87	51	65	and	and	CCONJ
hjic-87	51	66	stirring	stir	VERB
hjic-87	51	67	in	in	ADP
hjic-87	51	68	order	order	NOUN
hjic-87	51	69	to	to	PART
hjic-87	51	70	form	form	VERB
hjic-87	51	71	api	api	NOUN
hjic-87	51	72	-	-	PUNCT
hjic-87	51	73	coated	coat	VERB
hjic-87	51	74	liposomes	liposome	NOUN
hjic-87	51	75	[	[	X
hjic-87	51	76	12	12	NUM
hjic-87	51	77	]	]	PUNCT
hjic-87	51	78	.	.	PUNCT
hjic-87	52	1	to	to	PART
hjic-87	52	2	obtain	obtain	VERB
hjic-87	52	3	sub	sub	ADJ
hjic-87	52	4	-	-	ADJ
hjic-87	52	5	micron	micron	ADJ
hjic-87	52	6	particles	particle	NOUN
hjic-87	52	7	of	of	ADP
hjic-87	52	8	water	water	NOUN
hjic-87	52	9	-	-	PUNCT
hjic-87	52	10	insoluble	insoluble	ADJ
hjic-87	52	11	solids	solid	NOUN
hjic-87	52	12	henriksen	henriksen	PROPN
hjic-87	52	13	et	et	PROPN
hjic-87	52	14	al	al	PROPN
hjic-87	52	15	.	.	PROPN
hjic-87	52	16	submerged	submerge	VERB
hjic-87	52	17	the	the	DET
hjic-87	52	18	nozzle	nozzle	NOUN
hjic-87	52	19	of	of	ADP
hjic-87	52	20	ress	ress	NOUN
hjic-87	52	21	process	process	NOUN
hjic-87	52	22	in	in	ADP
hjic-87	52	23	an	an	DET
hjic-87	52	24	aqueous	aqueous	ADJ
hjic-87	52	25	solution	solution	NOUN
hjic-87	52	26	containing	contain	VERB
hjic-87	52	27	surfactants	surfactant	NOUN
hjic-87	52	28	,	,	PUNCT
hjic-87	52	29	typically	typically	ADV
hjic-87	52	30	phospholipids	phospholipid	VERB
hjic-87	52	31	[	[	X
hjic-87	52	32	13	13	NUM
hjic-87	52	33	]	]	PUNCT
hjic-87	52	34	.	.	PUNCT
hjic-87	53	1	in	in	ADP
hjic-87	53	2	another	another	DET
hjic-87	53	3	embodiment	embodiment	NOUN
hjic-87	53	4	of	of	ADP
hjic-87	53	5	the	the	DET
hjic-87	53	6	invention	invention	NOUN
hjic-87	53	7	api	api	NOUN
hjic-87	53	8	is	be	AUX
hjic-87	53	9	precipitated	precipitate	VERB
hjic-87	53	10	by	by	ADP
hjic-87	53	11	compressed	compressed	ADJ
hjic-87	53	12	gas	gas	NOUN
hjic-87	53	13	antisolvent	antisolvent	NOUN
hjic-87	53	14	method	method	NOUN
hjic-87	53	15	and	and	CCONJ
hjic-87	53	16	stabilized	stabilize	VERB
hjic-87	53	17	in	in	ADP
hjic-87	53	18	the	the	DET
hjic-87	53	19	aqueous	aqueous	ADJ
hjic-87	53	20	solution	solution	NOUN
hjic-87	53	21	.	.	PUNCT
hjic-87	54	1	stabilized	stabilize	VERB
hjic-87	54	2	suspensions	suspension	NOUN
hjic-87	54	3	of	of	ADP
hjic-87	54	4	cyclosporine	cyclosporine	NOUN
hjic-87	54	5	,	,	PUNCT
hjic-87	54	6	indomethacin	indomethacin	NOUN
hjic-87	54	7	and	and	CCONJ
hjic-87	54	8	tetracaine	tetracaine	NOUN
hjic-87	55	1	hi	hi	INTJ
hjic-87	55	2	nanoparticles	nanoparticle	NOUN
hjic-87	55	3	were	be	AUX
hjic-87	55	4	prepared	prepare	VERB
hjic-87	55	5	.	.	PUNCT
hjic-87	56	1	young	young	ADJ
hjic-87	56	2	et	et	PROPN
hjic-87	56	3	al	al	PROPN
hjic-87	56	4	.	.	PROPN
hjic-87	57	1	detailed	detail	VERB
hjic-87	57	2	the	the	DET
hjic-87	57	3	precipitation	precipitation	NOUN
hjic-87	57	4	of	of	ADP
hjic-87	57	5	cyclosporine	cyclosporine	PROPN
hjic-87	57	6	sprayed	spray	VERB
hjic-87	57	7	in	in	ADP
hjic-87	57	8	a	a	DET
hjic-87	57	9	solution	solution	NOUN
hjic-87	57	10	of	of	ADP
hjic-87	57	11	tween-80	tween-80	NUM
hjic-87	57	12	polymer	polymer	NOUN
hjic-87	57	13	.	.	PUNCT
hjic-87	58	1	the	the	DET
hjic-87	58	2	mean	mean	ADJ
hjic-87	58	3	particle	particle	NOUN
hjic-87	58	4	size	size	NOUN
hjic-87	58	5	was	be	AUX
hjic-87	58	6	between	between	ADP
hjic-87	58	7	400	400	NUM
hjic-87	58	8	and	and	CCONJ
hjic-87	58	9	700	700	NUM
hjic-87	58	10	nm	nm	NOUN
hjic-87	58	11	and	and	CCONJ
hjic-87	58	12	the	the	DET
hjic-87	58	13	solubility	solubility	NOUN
hjic-87	58	14	of	of	ADP
hjic-87	58	15	cyclosporine	cyclosporine	NOUN
hjic-87	58	16	increased	increase	VERB
hjic-87	58	17	significantly	significantly	ADV
hjic-87	58	18	[	[	X
hjic-87	58	19	14	14	NUM
hjic-87	58	20	]	]	PUNCT
hjic-87	58	21	.	.	PUNCT
hjic-87	59	1	resas	resa	NOUN
hjic-87	59	2	(	(	PUNCT
hjic-87	59	3	rapid	rapid	ADJ
hjic-87	59	4	expansion	expansion	NOUN
hjic-87	59	5	from	from	ADP
hjic-87	59	6	supercritical	supercritical	ADJ
hjic-87	59	7	to	to	ADP
hjic-87	59	8	aqueous	aqueous	ADJ
hjic-87	59	9	solution	solution	NOUN
hjic-87	59	10	)	)	PUNCT
hjic-87	59	11	is	be	AUX
hjic-87	59	12	a	a	DET
hjic-87	59	13	viable	viable	ADJ
hjic-87	59	14	method	method	NOUN
hjic-87	59	15	to	to	PART
hjic-87	59	16	enhance	enhance	VERB
hjic-87	59	17	the	the	DET
hjic-87	59	18	solubility	solubility	NOUN
hjic-87	59	19	of	of	ADP
hjic-87	59	20	actives	active	NOUN
hjic-87	59	21	principles	principle	NOUN
hjic-87	59	22	that	that	PRON
hjic-87	59	23	are	be	AUX
hjic-87	59	24	insoluble	insoluble	ADJ
hjic-87	59	25	in	in	ADP
hjic-87	59	26	water	water	NOUN
hjic-87	59	27	but	but	CCONJ
hjic-87	59	28	soluble	soluble	ADJ
hjic-87	59	29	in	in	ADP
hjic-87	59	30	scco2	scco2	PROPN
hjic-87	59	31	.	.	PUNCT
hjic-87	60	1	godinas	godinas	PROPN
hjic-87	60	2	et	et	PROPN
hjic-87	60	3	al	al	PROPN
hjic-87	60	4	.	.	PROPN
hjic-87	60	5	invented	invent	VERB
hjic-87	60	6	a	a	DET
hjic-87	60	7	process	process	NOUN
hjic-87	60	8	wherein	wherein	SCONJ
hjic-87	60	9	an	an	DET
hjic-87	60	10	active	active	ADJ
hjic-87	60	11	principle	principle	NOUN
hjic-87	60	12	together	together	ADV
hjic-87	60	13	with	with	ADP
hjic-87	60	14	a	a	DET
hjic-87	60	15	surface	surface	NOUN
hjic-87	60	16	modifier	modifier	NOUN
hjic-87	60	17	is	be	AUX
hjic-87	60	18	dissolved	dissolve	VERB
hjic-87	60	19	in	in	ADP
hjic-87	60	20	a	a	DET
hjic-87	60	21	dense	dense	ADJ
hjic-87	60	22	gas	gas	NOUN
hjic-87	60	23	which	which	PRON
hjic-87	60	24	is	be	AUX
hjic-87	60	25	afterwards	afterwards	ADV
hjic-87	60	26	expanded	expand	VERB
hjic-87	60	27	in	in	ADP
hjic-87	60	28	an	an	DET
hjic-87	60	29	aqueous	aqueous	ADJ
hjic-87	60	30	solution	solution	NOUN
hjic-87	60	31	containing	contain	VERB
hjic-87	60	32	a	a	DET
hjic-87	60	33	second	second	ADJ
hjic-87	60	34	–	–	PUNCT
hjic-87	60	35	optionally	optionally	ADV
hjic-87	60	36	,	,	PUNCT
hjic-87	60	37	identical	identical	ADJ
hjic-87	60	38	to	to	ADP
hjic-87	60	39	the	the	DET
hjic-87	60	40	first	first	ADJ
hjic-87	60	41	–	–	PUNCT
hjic-87	60	42	surface	surface	NOUN
hjic-87	60	43	modifier	modifier	NOUN
hjic-87	60	44	and	and	CCONJ
hjic-87	60	45	other	other	ADJ
hjic-87	60	46	additives	additive	NOUN
hjic-87	60	47	[	[	X
hjic-87	60	48	15	15	NUM
hjic-87	60	49	]	]	PUNCT
hjic-87	60	50	.	.	PUNCT
hjic-87	61	1	this	this	DET
hjic-87	61	2	technique	technique	NOUN
hjic-87	61	3	was	be	AUX
hjic-87	61	4	patented	patent	VERB
hjic-87	61	5	by	by	ADP
hjic-87	61	6	the	the	DET
hjic-87	61	7	name	name	NOUN
hjic-87	61	8	of	of	ADP
hjic-87	61	9	rapid	rapid	ADJ
hjic-87	61	10	expansion	expansion	NOUN
hjic-87	61	11	of	of	ADP
hjic-87	61	12	liquefied	liquefy	VERB
hjic-87	61	13	gas	gas	NOUN
hjic-87	61	14	solution	solution	NOUN
hjic-87	61	15	(	(	PUNCT
hjic-87	61	16	relgs	relgs	NOUN
hjic-87	61	17	)	)	PUNCT
hjic-87	61	18	or	or	CCONJ
hjic-87	61	19	rapid	rapid	ADJ
hjic-87	61	20	expansion	expansion	NOUN
hjic-87	61	21	of	of	ADP
hjic-87	61	22	liquefied	liquefy	VERB
hjic-87	61	23	gas	gas	NOUN
hjic-87	61	24	solution	solution	NOUN
hjic-87	61	25	and	and	CCONJ
hjic-87	61	26	homogenization	homogenization	NOUN
hjic-87	61	27	(	(	PUNCT
hjic-87	61	28	relgs	relgs	NOUN
hjic-87	61	29	-	-	PUNCT
hjic-87	61	30	h	h	NOUN
hjic-87	61	31	)	)	PUNCT
hjic-87	61	32	.	.	PUNCT
hjic-87	62	1	suspensions	suspension	NOUN
hjic-87	62	2	of	of	ADP
hjic-87	62	3	fenofibrate	fenofibrate	NOUN
hjic-87	62	4	and	and	CCONJ
hjic-87	62	5	cyclosporine	cyclosporine	PROPN
hjic-87	62	6	were	be	AUX
hjic-87	62	7	prepared	prepare	VERB
hjic-87	62	8	with	with	ADP
hjic-87	62	9	mean	mean	ADJ
hjic-87	62	10	particle	particle	NOUN
hjic-87	62	11	sizes	size	NOUN
hjic-87	62	12	of	of	ADP
hjic-87	62	13	200	200	NUM
hjic-87	62	14	and	and	CCONJ
hjic-87	62	15	23	23	NUM
hjic-87	62	16	nm	nm	NOUN
hjic-87	62	17	,	,	PUNCT
hjic-87	62	18	respectively	respectively	ADV
hjic-87	62	19	.	.	PUNCT
hjic-87	63	1	the	the	DET
hjic-87	63	2	surface	surface	NOUN
hjic-87	63	3	modifiers	modifier	NOUN
hjic-87	63	4	were	be	AUX
hjic-87	63	5	lipoid-80	lipoid-80	ADJ
hjic-87	63	6	and	and	CCONJ
hjic-87	63	7	tween-80	tween-80	NUM
hjic-87	63	8	dissolved	dissolve	VERB
hjic-87	63	9	in	in	ADP
hjic-87	63	10	scco2	scco2	NOUN
hjic-87	63	11	in	in	ADP
hjic-87	63	12	the	the	DET
hjic-87	63	13	case	case	NOUN
hjic-87	63	14	of	of	ADP
hjic-87	63	15	fenofibrate	fenofibrate	NOUN
hjic-87	63	16	and	and	CCONJ
hjic-87	63	17	tween-80	tween-80	NOUN
hjic-87	63	18	in	in	ADP
hjic-87	63	19	fluid	fluid	ADJ
hjic-87	63	20	phase	phase	NOUN
hjic-87	63	21	with	with	ADP
hjic-87	63	22	egg	egg	NOUN
hjic-87	63	23	phospholipid	phospholipid	NOUN
hjic-87	63	24	and	and	CCONJ
hjic-87	63	25	mannitol	mannitol	NOUN
hjic-87	63	26	in	in	ADP
hjic-87	63	27	aqueous	aqueous	ADJ
hjic-87	63	28	phase	phase	NOUN
hjic-87	63	29	for	for	ADP
hjic-87	63	30	cyclosporine	cyclosporine	NOUN
hjic-87	63	31	.	.	PUNCT
hjic-87	64	1	obviously	obviously	ADV
hjic-87	64	2	,	,	PUNCT
hjic-87	64	3	the	the	DET
hjic-87	64	4	latter	latter	ADJ
hjic-87	64	5	three	three	NUM
hjic-87	64	6	inventions	invention	NOUN
hjic-87	64	7	–	–	PUNCT
hjic-87	64	8	resas	resa	NOUN
hjic-87	64	9	,	,	PUNCT
hjic-87	64	10	relgs	relgs	NOUN
hjic-87	64	11	and	and	CCONJ
hjic-87	64	12	relgs	relgs	NOUN
hjic-87	64	13	-	-	PUNCT
hjic-87	64	14	h	h	NOUN
hjic-87	64	15	–	–	PUNCT
hjic-87	64	16	are	be	AUX
hjic-87	64	17	applicable	applicable	ADJ
hjic-87	64	18	only	only	ADV
hjic-87	64	19	in	in	ADP
hjic-87	64	20	the	the	DET
hjic-87	64	21	case	case	NOUN
hjic-87	64	22	of	of	ADP
hjic-87	64	23	water	water	NOUN
hjic-87	64	24	-	-	PUNCT
hjic-87	64	25	insoluble	insoluble	ADJ
hjic-87	64	26	compounds	compound	NOUN
hjic-87	64	27	.	.	PUNCT
hjic-87	65	1	also	also	ADV
hjic-87	65	2	,	,	PUNCT
hjic-87	65	3	in	in	ADP
hjic-87	65	4	1999	1999	NUM
hjic-87	65	5	,	,	PUNCT
hjic-87	65	6	bausch	bausch	PROPN
hjic-87	65	7	et	et	PROPN
hjic-87	65	8	al	al	PROPN
hjic-87	65	9	.	.	PROPN
hjic-87	65	10	patented	patent	VERB
hjic-87	65	11	a	a	DET
hjic-87	65	12	method	method	NOUN
hjic-87	65	13	wherein	wherein	SCONJ
hjic-87	65	14	a	a	DET
hjic-87	65	15	biologically	biologically	ADV
hjic-87	65	16	active	active	ADJ
hjic-87	65	17	substrate	substrate	NOUN
hjic-87	65	18	is	be	AUX
hjic-87	65	19	dissolved	dissolve	VERB
hjic-87	65	20	in	in	ADP
hjic-87	65	21	a	a	DET
hjic-87	65	22	compressed	compressed	ADJ
hjic-87	65	23	gas	gas	NOUN
hjic-87	65	24	,	,	PUNCT
hjic-87	65	25	liquid	liquid	NOUN
hjic-87	65	26	or	or	CCONJ
hjic-87	65	27	scf	scf	NOUN
hjic-87	65	28	containing	contain	VERB
hjic-87	65	29	a	a	DET
hjic-87	65	30	surface	surface	NOUN
hjic-87	65	31	modifier	modifier	NOUN
hjic-87	65	32	,	,	PUNCT
hjic-87	65	33	and	and	CCONJ
hjic-87	65	34	is	be	AUX
hjic-87	65	35	either	either	CCONJ
hjic-87	65	36	expanded	expand	VERB
hjic-87	65	37	to	to	ADP
hjic-87	65	38	lower	low	ADJ
hjic-87	65	39	pressure	pressure	NOUN
hjic-87	65	40	or	or	CCONJ
hjic-87	65	41	dispersed	disperse	VERB
hjic-87	65	42	in	in	ADP
hjic-87	65	43	an	an	DET
hjic-87	65	44	anti	anti	ADJ
hjic-87	65	45	-	-	ADJ
hjic-87	65	46	solvent	solvent	ADJ
hjic-87	65	47	phase	phase	NOUN
hjic-87	65	48	[	[	X
hjic-87	65	49	16	16	NUM
hjic-87	65	50	]	]	PUNCT
hjic-87	65	51	.	.	PUNCT
hjic-87	66	1	table	table	NOUN
hjic-87	66	2	1	1	NUM
hjic-87	66	3	.	.	PUNCT
hjic-87	67	1	summary	summary	NOUN
hjic-87	67	2	of	of	ADP
hjic-87	67	3	drug	drug	NOUN
hjic-87	67	4	-	-	PUNCT
hjic-87	67	5	carrier	carrier	NOUN
hjic-87	67	6	systems	system	NOUN
hjic-87	67	7	precipitated	precipitate	VERB
hjic-87	67	8	by	by	ADP
hjic-87	67	9	ress	ress	NOUN
hjic-87	67	10	and	and	CCONJ
hjic-87	67	11	related	related	ADJ
hjic-87	67	12	methods	method	NOUN
hjic-87	67	13	.	.	PUNCT
hjic-87	68	1	substrate	substrate	NOUN
hjic-87	68	2	excipient	excipient	ADJ
hjic-87	68	3	observation	observation	NOUN
hjic-87	68	4	references	reference	NOUN
hjic-87	68	5	lovastatin	lovastatin	PROPN
hjic-87	68	6	pla	pla	PROPN
hjic-87	68	7	needles	needle	NOUN
hjic-87	68	8	of	of	ADP
hjic-87	68	9	substrate	substrate	NOUN
hjic-87	68	10	in	in	ADP
hjic-87	68	11	polymer	polymer	NOUN
hjic-87	68	12	microspheres	microsphere	NOUN
hjic-87	68	13	[	[	X
hjic-87	68	14	17	17	NUM
hjic-87	68	15	]	]	X
hjic-87	68	16	pyrene	pyrene	NOUN
hjic-87	68	17	pla	pla	PROPN
hjic-87	68	18	solid	solid	ADJ
hjic-87	68	19	dispersion	dispersion	NOUN
hjic-87	68	20	[	[	X
hjic-87	68	21	18	18	NUM
hjic-87	68	22	]	]	X
hjic-87	68	23	znpc(so3h)4	znpc(so3h)4	PROPN
hjic-87	68	24	a	a	DET
hjic-87	68	25	fitc	fitc	NOUN
hjic-87	68	26	-	-	PUNCT
hjic-87	68	27	dextranb	dextranb	VERB
hjic-87	68	28	popc	popc	PROPN
hjic-87	68	29	c	c	PROPN
hjic-87	68	30	cholesetrol	cholesetrol	PROPN
hjic-87	68	31	liposomes	liposome	NOUN
hjic-87	68	32	,	,	PUNCT
hjic-87	68	33	200	200	NUM
hjic-87	68	34	nm	nm	NOUN
hjic-87	68	35	[	[	X
hjic-87	68	36	10,11	10,11	NOUN
hjic-87	68	37	]	]	X
hjic-87	68	38	naproxen	naproxen	NOUN
hjic-87	68	39	pla	pla	NOUN
hjic-87	68	40	microcapsules	microcapsule	NOUN
hjic-87	69	1	[	[	X
hjic-87	69	2	19	19	NUM
hjic-87	69	3	]	]	PUNCT
hjic-87	69	4	cyclosporine	cyclosporine	ADJ
hjic-87	69	5	tween	tween	NOUN
hjic-87	69	6	80	80	NUM
hjic-87	69	7	phospholipid	phospholipid	NOUN
hjic-87	69	8	suspension	suspension	NOUN
hjic-87	69	9	,	,	PUNCT
hjic-87	69	10	28	28	NUM
hjic-87	69	11	–	–	PUNCT
hjic-87	69	12	80,9	80,9	NUM
hjic-87	69	13	nm	nm	NOUN
hjic-87	69	14	[	[	X
hjic-87	69	15	10	10	NUM
hjic-87	69	16	]	]	SYM
hjic-87	69	17	flavone	flavone	NOUN
hjic-87	69	18	3	3	X
hjic-87	69	19	-	-	NUM
hjic-87	69	20	hydroxyflavone	hydroxyflavone	NOUN
hjic-87	69	21	peg	peg	NOUN
hjic-87	69	22	mean	mean	NOUN
hjic-87	69	23	particle	particle	NOUN
hjic-87	69	24	size	size	NOUN
hjic-87	69	25	:	:	PUNCT
hjic-87	69	26	10	10	NUM
hjic-87	69	27	µm	µm	PART
hjic-87	69	28	[	[	X
hjic-87	69	29	7	7	NUM
hjic-87	69	30	]	]	PUNCT
hjic-87	69	31	fenofibrate	fenofibrate	NOUN
hjic-87	69	32	lipoid	lipoid	PROPN
hjic-87	69	33	e80	e80	PROPN
hjic-87	69	34	tween	tween	NOUN
hjic-87	69	35	80	80	NUM
hjic-87	69	36	suspension	suspension	NOUN
hjic-87	69	37	,	,	PUNCT
hjic-87	69	38	0,2	0,2	NUM
hjic-87	69	39	µm	µm	ADP
hjic-87	69	40	cyclosporine	cyclosporine	ADJ
hjic-87	69	41	tween	tween	NOUN
hjic-87	69	42	80	80	NUM
hjic-87	69	43	mean	mean	NOUN
hjic-87	69	44	particle	particle	NOUN
hjic-87	69	45	size	size	NOUN
hjic-87	69	46	:	:	PUNCT
hjic-87	69	47	23	23	NUM
hjic-87	69	48	nm	nm	NOUN
hjic-87	70	1	[	[	X
hjic-87	70	2	15	15	NUM
hjic-87	70	3	]	]	X
hjic-87	70	4	tetrahydrolipstatin	tetrahydrolipstatin	NOUN
hjic-87	70	5	brij	brij	PROPN
hjic-87	70	6	96	96	NUM
hjic-87	70	7	mean	mean	ADJ
hjic-87	70	8	particle	particle	NOUN
hjic-87	70	9	size	size	NOUN
hjic-87	70	10	:	:	PUNCT
hjic-87	70	11	1,4	1,4	NUM
hjic-87	70	12	–	–	PUNCT
hjic-87	70	13	2,1	2,1	NUM
hjic-87	70	14	µm	µm	NUM
hjic-87	70	15	aerosol	aerosol	NOUN
hjic-87	70	16	ot	ot	NOUN
hjic-87	70	17	mean	mean	VERB
hjic-87	70	18	particle	particle	NOUN
hjic-87	70	19	size	size	NOUN
hjic-87	70	20	:	:	PUNCT
hjic-87	70	21	0,8	0,8	NUM
hjic-87	70	22	–	–	PUNCT
hjic-87	70	23	3,8	3,8	NUM
hjic-87	70	24	µm	µm	ADP
hjic-87	70	25	saquinavir	saquinavir	PROPN
hjic-87	70	26	brij	brij	PROPN
hjic-87	71	1	96	96	NUM
hjic-87	71	2	mean	mean	ADJ
hjic-87	71	3	particle	particle	NOUN
hjic-87	71	4	size	size	NOUN
hjic-87	71	5	:	:	PUNCT
hjic-87	71	6	1,4	1,4	NUM
hjic-87	71	7	µm	µm	ADP
hjic-87	71	8	[	[	X
hjic-87	71	9	16	16	NUM
hjic-87	71	10	]	]	PUNCT
hjic-87	71	11	cyclosporine	cyclosporine	NOUN
hjic-87	71	12	tween	tween	NOUN
hjic-87	71	13	80	80	NUM
hjic-87	71	14	suspension	suspension	NOUN
hjic-87	71	15	,	,	PUNCT
hjic-87	71	16	0,5	0,5	NUM
hjic-87	71	17	-	-	PUNCT
hjic-87	71	18	0,7	0,7	NUM
hjic-87	71	19	µm	µm	ADP
hjic-87	71	20	[	[	X
hjic-87	71	21	14	14	NUM
hjic-87	71	22	]	]	SYM
hjic-87	71	23	3	3	NUM
hjic-87	71	24	-	-	NUM
hjic-87	71	25	hydroxyflavone	hydroxyflavone	NUM
hjic-87	71	26	eudragit	eudragit	NOUN
hjic-87	71	27	e100	e100	PROPN
hjic-87	71	28	microcapsules	microcapsule	NOUN
hjic-87	71	29	[	[	X
hjic-87	71	30	8	8	NUM
hjic-87	71	31	]	]	ADJ
hjic-87	71	32	lipase	lipase	NOUN
hjic-87	71	33	lysosyme	lysosyme	NOUN
hjic-87	71	34	peg	peg	NOUN
hjic-87	71	35	pla	pla	PROPN
hjic-87	71	36	plga	plga	VERB
hjic-87	71	37	pmma	pmma	PROPN
hjic-87	71	38	poloxamer	poloxamer	PROPN
hjic-87	71	39	microcapsules	microcapsule	NOUN
hjic-87	71	40	,	,	PUNCT
hjic-87	71	41	6	6	NUM
hjic-87	71	42	62	62	NUM
hjic-87	71	43	µm	µm	ADP
hjic-87	71	44	[	[	NOUN
hjic-87	71	45	9	9	NUM
hjic-87	71	46	]	]	PUNCT
hjic-87	71	47	lidocaine	lidocaine	NOUN
hjic-87	71	48	peg	peg	NOUN
hjic-87	71	49	8000	8000	NUM
hjic-87	71	50	solid	solid	ADJ
hjic-87	71	51	dispersion	dispersion	NOUN
hjic-87	72	1	[	[	X
hjic-87	72	2	20	20	NUM
hjic-87	72	3	]	]	PUNCT
hjic-87	72	4	a	a	DET
hjic-87	72	5	zinc	zinc	NOUN
hjic-87	72	6	-	-	PUNCT
hjic-87	72	7	phthalocyanine	phthalocyanine	NOUN
hjic-87	72	8	tetrasulfonate	tetrasulfonate	NOUN
hjic-87	72	9	;	;	PUNCT
hjic-87	72	10	b	b	X
hjic-87	72	11	fluorescein	fluorescein	ADJ
hjic-87	72	12	isothiocyanate	isothiocyanate	NOUN
hjic-87	72	13	-	-	PUNCT
hjic-87	72	14	dextran	dextran	NOUN
hjic-87	72	15	;	;	PUNCT
hjic-87	72	16	c	c	NOUN
hjic-87	72	17	1	1	NUM
hjic-87	72	18	-	-	PUNCT
hjic-87	72	19	palmitoyl-2	palmitoyl-2	VERB
hjic-87	72	20	-	-	PUNCT
hjic-87	72	21	oleoylphosphatidylcholine	oleoylphosphatidylcholine	NOUN
hjic-87	72	22	;	;	PUNCT
hjic-87	72	23	44	44	NUM
hjic-87	72	24	particles	particle	NOUN
hjic-87	72	25	from	from	ADP
hjic-87	72	26	gas	gas	NOUN
hjic-87	72	27	-	-	PUNCT
hjic-87	72	28	saturated	saturate	VERB
hjic-87	72	29	solution	solution	NOUN
hjic-87	72	30	(	(	PUNCT
hjic-87	72	31	pgss	pgss	ADJ
hjic-87	72	32	)	)	PUNCT
hjic-87	72	33	pgss	pgss	NOUN
hjic-87	72	34	consists	consist	VERB
hjic-87	72	35	in	in	ADP
hjic-87	72	36	dissolving	dissolve	VERB
hjic-87	72	37	a	a	DET
hjic-87	72	38	compressed	compressed	ADJ
hjic-87	72	39	gas	gas	NOUN
hjic-87	72	40	–	–	PUNCT
hjic-87	72	41	supercritical	supercritical	ADJ
hjic-87	72	42	fluid	fluid	NOUN
hjic-87	72	43	–	–	PUNCT
hjic-87	72	44	in	in	ADP
hjic-87	72	45	a	a	DET
hjic-87	72	46	molten	molten	ADJ
hjic-87	72	47	solid	solid	ADJ
hjic-87	72	48	or	or	CCONJ
hjic-87	72	49	in	in	ADP
hjic-87	72	50	a	a	DET
hjic-87	72	51	solution	solution	NOUN
hjic-87	72	52	or	or	CCONJ
hjic-87	72	53	suspension	suspension	NOUN
hjic-87	72	54	of	of	ADP
hjic-87	72	55	solid	solid	ADJ
hjic-87	72	56	substance	substance	NOUN
hjic-87	72	57	followed	follow	VERB
hjic-87	72	58	by	by	ADP
hjic-87	72	59	a	a	DET
hjic-87	72	60	rapid	rapid	ADJ
hjic-87	72	61	expansion	expansion	NOUN
hjic-87	72	62	to	to	PART
hjic-87	72	63	lower	low	ADJ
hjic-87	72	64	–	–	PUNCT
hjic-87	72	65	atmospheric	atmospheric	ADJ
hjic-87	72	66	–	–	PUNCT
hjic-87	72	67	pressure	pressure	NOUN
hjic-87	72	68	[	[	X
hjic-87	72	69	21	21	NUM
hjic-87	72	70	]	]	PUNCT
hjic-87	72	71	.	.	PUNCT
hjic-87	73	1	the	the	DET
hjic-87	73	2	very	very	ADV
hjic-87	73	3	first	first	ADJ
hjic-87	73	4	application	application	NOUN
hjic-87	73	5	of	of	ADP
hjic-87	73	6	the	the	DET
hjic-87	73	7	pgss	pgss	ADJ
hjic-87	73	8	concept	concept	NOUN
hjic-87	73	9	related	relate	VERB
hjic-87	73	10	mostly	mostly	ADV
hjic-87	73	11	to	to	PART
hjic-87	73	12	paint	paint	VERB
hjic-87	73	13	and	and	CCONJ
hjic-87	73	14	polymer	polymer	NOUN
hjic-87	73	15	industry	industry	NOUN
hjic-87	73	16	particularly	particularly	ADV
hjic-87	73	17	to	to	ADP
hjic-87	73	18	powder	powder	NOUN
hjic-87	73	19	coating	coating	NOUN
hjic-87	73	20	[	[	X
hjic-87	73	21	22	22	NUM
hjic-87	73	22	]	]	PUNCT
hjic-87	73	23	.	.	PUNCT
hjic-87	74	1	since	since	SCONJ
hjic-87	74	2	the	the	DET
hjic-87	74	3	solubilities	solubility	NOUN
hjic-87	74	4	of	of	ADP
hjic-87	74	5	compressed	compress	VERB
hjic-87	74	6	gases	gas	NOUN
hjic-87	74	7	in	in	ADP
hjic-87	74	8	liquids	liquid	NOUN
hjic-87	74	9	and	and	CCONJ
hjic-87	74	10	solids	solid	NOUN
hjic-87	74	11	like	like	ADP
hjic-87	74	12	polymers	polymer	NOUN
hjic-87	74	13	are	be	AUX
hjic-87	74	14	usually	usually	ADV
hjic-87	74	15	much	much	ADV
hjic-87	74	16	higher	high	ADJ
hjic-87	74	17	then	then	ADV
hjic-87	74	18	those	those	PRON
hjic-87	74	19	of	of	ADP
hjic-87	74	20	such	such	ADJ
hjic-87	74	21	liquids	liquid	NOUN
hjic-87	74	22	and	and	CCONJ
hjic-87	74	23	solids	solid	NOUN
hjic-87	74	24	in	in	ADP
hjic-87	74	25	the	the	DET
hjic-87	74	26	compressed	compress	VERB
hjic-87	74	27	gas	gas	NOUN
hjic-87	74	28	this	this	DET
hjic-87	74	29	method	method	NOUN
hjic-87	74	30	is	be	AUX
hjic-87	74	31	proved	prove	VERB
hjic-87	74	32	to	to	PART
hjic-87	74	33	be	be	AUX
hjic-87	74	34	more	more	ADV
hjic-87	74	35	advantageous	advantageous	ADJ
hjic-87	74	36	over	over	ADP
hjic-87	74	37	ress	ress	NOUN
hjic-87	74	38	.	.	PUNCT
hjic-87	75	1	active	active	ADJ
hjic-87	75	2	ingredients	ingredient	NOUN
hjic-87	75	3	can	can	AUX
hjic-87	75	4	be	be	AUX
hjic-87	75	5	micronized	micronize	VERB
hjic-87	75	6	from	from	ADP
hjic-87	75	7	aqueous	aqueous	ADJ
hjic-87	75	8	solution	solution	NOUN
hjic-87	75	9	as	as	ADV
hjic-87	75	10	well	well	ADV
hjic-87	75	11	according	accord	VERB
hjic-87	75	12	to	to	ADP
hjic-87	75	13	the	the	DET
hjic-87	75	14	patent	patent	NOUN
hjic-87	75	15	of	of	ADP
hjic-87	75	16	sievers	sievers	PROPN
hjic-87	75	17	et	et	PROPN
hjic-87	75	18	al	al	PROPN
hjic-87	75	19	.	.	PUNCT
hjic-87	76	1	[	[	X
hjic-87	76	2	23	23	NUM
hjic-87	76	3	]	]	PUNCT
hjic-87	76	4	.	.	PUNCT
hjic-87	77	1	since	since	SCONJ
hjic-87	77	2	co2	co2	NOUN
hjic-87	77	3	is	be	AUX
hjic-87	77	4	one	one	NUM
hjic-87	77	5	of	of	ADP
hjic-87	77	6	the	the	DET
hjic-87	77	7	most	most	ADV
hjic-87	77	8	soluble	soluble	ADJ
hjic-87	77	9	gases	gas	NOUN
hjic-87	77	10	in	in	ADP
hjic-87	77	11	water	water	NOUN
hjic-87	77	12	,	,	PUNCT
hjic-87	77	13	depressurization	depressurization	NOUN
hjic-87	77	14	of	of	ADP
hjic-87	77	15	the	the	DET
hjic-87	77	16	ternary	ternary	ADJ
hjic-87	77	17	mixture	mixture	NOUN
hjic-87	77	18	–	–	PUNCT
hjic-87	77	19	solid	solid	ADJ
hjic-87	77	20	-	-	PUNCT
hjic-87	77	21	water	water	NOUN
hjic-87	77	22	-	-	PUNCT
hjic-87	77	23	co2	co2	NOUN
hjic-87	77	24	–	–	PUNCT
hjic-87	77	25	produce	produce	VERB
hjic-87	77	26	extremely	extremely	ADV
hjic-87	77	27	high	high	ADJ
hjic-87	77	28	expansion	expansion	NOUN
hjic-87	77	29	.	.	PUNCT
hjic-87	78	1	water	water	NOUN
hjic-87	78	2	can	can	AUX
hjic-87	78	3	be	be	AUX
hjic-87	78	4	evaporated	evaporate	VERB
hjic-87	78	5	from	from	ADP
hjic-87	78	6	the	the	DET
hjic-87	78	7	aerosol	aerosol	NOUN
hjic-87	78	8	in	in	ADP
hjic-87	78	9	high	high	ADJ
hjic-87	78	10	temperature	temperature	NOUN
hjic-87	78	11	furnace	furnace	NOUN
hjic-87	78	12	to	to	PART
hjic-87	78	13	obtain	obtain	VERB
hjic-87	78	14	dry	dry	ADJ
hjic-87	78	15	powder	powder	NOUN
hjic-87	78	16	.	.	PUNCT
hjic-87	79	1	in	in	ADP
hjic-87	79	2	1998	1998	NUM
hjic-87	79	3	shine	shine	NOUN
hjic-87	79	4	et	et	PROPN
hjic-87	79	5	al	al	PROPN
hjic-87	79	6	.	.	PROPN
hjic-87	79	7	patented	patent	VERB
hjic-87	79	8	a	a	DET
hjic-87	79	9	method	method	NOUN
hjic-87	79	10	called	call	VERB
hjic-87	79	11	polymer	polymer	NOUN
hjic-87	79	12	liquefaction	liquefaction	NOUN
hjic-87	79	13	using	use	VERB
hjic-87	79	14	supercritical	supercritical	ADJ
hjic-87	79	15	solvating	solvating	NOUN
hjic-87	79	16	(	(	PUNCT
hjic-87	79	17	pluss	pluss	NOUN
hjic-87	79	18	)	)	PUNCT
hjic-87	79	19	whereby	whereby	SCONJ
hjic-87	79	20	pgss	pgss	ADJ
hjic-87	79	21	method	method	NOUN
hjic-87	79	22	is	be	AUX
hjic-87	79	23	applicable	applicable	ADJ
hjic-87	79	24	below	below	ADP
hjic-87	79	25	the	the	DET
hjic-87	79	26	melting	melting	NOUN
hjic-87	79	27	point	point	NOUN
hjic-87	79	28	of	of	ADP
hjic-87	79	29	the	the	DET
hjic-87	79	30	processed	process	VERB
hjic-87	79	31	material	material	NOUN
hjic-87	79	32	[	[	X
hjic-87	79	33	24	24	NUM
hjic-87	79	34	]	]	PUNCT
hjic-87	79	35	.	.	PUNCT
hjic-87	80	1	as	as	SCONJ
hjic-87	80	2	polymers	polymer	NOUN
hjic-87	80	3	in	in	ADP
hjic-87	80	4	high	high	ADJ
hjic-87	80	5	pressure	pressure	NOUN
hjic-87	80	6	co2	co2	NOUN
hjic-87	80	7	atmosphere	atmosphere	NOUN
hjic-87	80	8	swell	swell	VERB
hjic-87	80	9	or	or	CCONJ
hjic-87	80	10	melt	melt	VERB
hjic-87	80	11	at	at	ADP
hjic-87	80	12	lower	low	ADJ
hjic-87	80	13	temperature	temperature	NOUN
hjic-87	80	14	,	,	PUNCT
hjic-87	80	15	active	active	ADJ
hjic-87	80	16	substrates	substrate	NOUN
hjic-87	80	17	can	can	AUX
hjic-87	80	18	be	be	AUX
hjic-87	80	19	dispersed	disperse	VERB
hjic-87	80	20	and	and	CCONJ
hjic-87	80	21	encapsulated	encapsulate	VERB
hjic-87	80	22	without	without	ADP
hjic-87	80	23	any	any	DET
hjic-87	80	24	thermal	thermal	ADJ
hjic-87	80	25	degradation	degradation	NOUN
hjic-87	80	26	.	.	PUNCT
hjic-87	81	1	shakeseff	shakeseff	NOUN
hjic-87	81	2	and	and	CCONJ
hjic-87	81	3	coworkers	coworker	NOUN
hjic-87	81	4	from	from	ADP
hjic-87	81	5	the	the	DET
hjic-87	81	6	university	university	PROPN
hjic-87	81	7	of	of	ADP
hjic-87	81	8	nottingham	nottingham	PROPN
hjic-87	81	9	have	have	AUX
hjic-87	81	10	successfully	successfully	ADV
hjic-87	81	11	applied	apply	VERB
hjic-87	81	12	scco2	scco2	NOUN
hjic-87	81	13	as	as	ADP
hjic-87	81	14	dispersing	disperse	VERB
hjic-87	81	15	and	and	CCONJ
hjic-87	81	16	plasticizing	plasticize	VERB
hjic-87	81	17	fluid	fluid	NOUN
hjic-87	81	18	to	to	PART
hjic-87	81	19	prepare	prepare	VERB
hjic-87	81	20	composites	composite	NOUN
hjic-87	81	21	of	of	ADP
hjic-87	81	22	biologically	biologically	ADV
hjic-87	81	23	active	active	ADJ
hjic-87	81	24	materials	material	NOUN
hjic-87	81	25	and	and	CCONJ
hjic-87	81	26	polymers	polymer	NOUN
hjic-87	81	27	[	[	X
hjic-87	81	28	25	25	NUM
hjic-87	81	29	-	-	SYM
hjic-87	81	30	28	28	NUM
hjic-87	81	31	]	]	PUNCT
hjic-87	81	32	.	.	PUNCT
hjic-87	82	1	kerc	kerc	INTJ
hjic-87	82	2	et	et	PROPN
hjic-87	82	3	al	al	PROPN
hjic-87	82	4	.	.	PROPN
hjic-87	82	5	described	describe	VERB
hjic-87	82	6	the	the	DET
hjic-87	82	7	micronization	micronization	NOUN
hjic-87	82	8	of	of	ADP
hjic-87	82	9	three	three	NUM
hjic-87	82	10	pure	pure	ADJ
hjic-87	82	11	drugs	drug	NOUN
hjic-87	82	12	(	(	PUNCT
hjic-87	82	13	nifedipine	nifedipine	NOUN
hjic-87	82	14	,	,	PUNCT
hjic-87	82	15	felodipine	felodipine	NOUN
hjic-87	82	16	and	and	CCONJ
hjic-87	82	17	fenofibrate	fenofibrate	NOUN
hjic-87	82	18	)	)	PUNCT
hjic-87	82	19	as	as	ADV
hjic-87	82	20	well	well	ADV
hjic-87	82	21	as	as	ADP
hjic-87	82	22	their	their	PRON
hjic-87	82	23	composites	composite	NOUN
hjic-87	82	24	with	with	ADP
hjic-87	82	25	peg	peg	NOUN
hjic-87	82	26	4000	4000	NUM
hjic-87	82	27	polymer	polymer	NOUN
hjic-87	82	28	by	by	ADP
hjic-87	82	29	pgss	pgss	ADJ
hjic-87	82	30	process	process	NOUN
hjic-87	82	31	[	[	X
hjic-87	82	32	29	29	NUM
hjic-87	82	33	]	]	PUNCT
hjic-87	82	34	.	.	PUNCT
hjic-87	83	1	the	the	DET
hjic-87	83	2	addition	addition	NOUN
hjic-87	83	3	of	of	ADP
hjic-87	83	4	polymer	polymer	NOUN
hjic-87	83	5	to	to	ADP
hjic-87	83	6	the	the	DET
hjic-87	83	7	solid	solid	ADJ
hjic-87	83	8	substance	substance	NOUN
hjic-87	83	9	avoids	avoid	VERB
hjic-87	83	10	agglomeration	agglomeration	NOUN
hjic-87	83	11	,	,	PUNCT
hjic-87	83	12	enhances	enhance	VERB
hjic-87	83	13	the	the	DET
hjic-87	83	14	solubility	solubility	NOUN
hjic-87	83	15	of	of	ADP
hjic-87	83	16	treated	treat	VERB
hjic-87	83	17	drug	drug	NOUN
hjic-87	83	18	in	in	ADP
hjic-87	83	19	water	water	NOUN
hjic-87	83	20	and	and	CCONJ
hjic-87	83	21	decreases	decrease	VERB
hjic-87	83	22	considerably	considerably	ADV
hjic-87	83	23	the	the	DET
hjic-87	83	24	process	process	NOUN
hjic-87	83	25	temperature	temperature	NOUN
hjic-87	83	26	[	[	X
hjic-87	83	27	30	30	NUM
hjic-87	83	28	]	]	PUNCT
hjic-87	83	29	.	.	PUNCT
hjic-87	84	1	table	table	NOUN
hjic-87	84	2	2	2	NUM
hjic-87	84	3	summary	summary	NOUN
hjic-87	84	4	of	of	ADP
hjic-87	84	5	drug	drug	NOUN
hjic-87	84	6	-	-	PUNCT
hjic-87	84	7	carrier	carrier	NOUN
hjic-87	84	8	systems	system	NOUN
hjic-87	84	9	precipitated	precipitate	VERB
hjic-87	84	10	by	by	ADP
hjic-87	84	11	pgss	pgss	ADJ
hjic-87	84	12	and	and	CCONJ
hjic-87	84	13	related	related	ADJ
hjic-87	84	14	methods	method	NOUN
hjic-87	84	15	.	.	PUNCT
hjic-87	85	1	substrate	substrate	NOUN
hjic-87	85	2	excipient	excipient	ADJ
hjic-87	85	3	observation	observation	NOUN
hjic-87	85	4	references	reference	NOUN
hjic-87	85	5	ibdv	ibdv	VERB
hjic-87	85	6	vaccinea	vaccinea	NOUN
hjic-87	85	7	polycaprolactone	polycaprolactone	NOUN
hjic-87	85	8	agglomeration	agglomeration	NOUN
hjic-87	85	9	of	of	ADP
hjic-87	85	10	fine	fine	ADJ
hjic-87	85	11	particles	particle	NOUN
hjic-87	85	12	[	[	X
hjic-87	85	13	24	24	NUM
hjic-87	85	14	]	]	PUNCT
hjic-87	85	15	nifedipine	nifedipine	NOUN
hjic-87	85	16	peg	peg	NOUN
hjic-87	85	17	4000	4000	NUM
hjic-87	85	18	non	non	ADJ
hjic-87	85	19	-	-	ADJ
hjic-87	85	20	regular	regular	ADJ
hjic-87	85	21	porous	porous	ADJ
hjic-87	85	22	particles	particle	NOUN
hjic-87	85	23	[	[	X
hjic-87	85	24	30	30	NUM
hjic-87	85	25	]	]	X
hjic-87	85	26	nifedipine	nifedipine	PROPN
hjic-87	85	27	felodipine	felodipine	PROPN
hjic-87	85	28	fenofibrate	fenofibrate	NOUN
hjic-87	85	29	peg	peg	NOUN
hjic-87	85	30	4000	4000	NUM
hjic-87	85	31	mean	mean	NOUN
hjic-87	85	32	particle	particle	NOUN
hjic-87	85	33	size	size	NOUN
hjic-87	85	34	:	:	PUNCT
hjic-87	85	35	16	16	NUM
hjic-87	85	36	30	30	NUM
hjic-87	85	37	µm	µm	ADP
hjic-87	85	38	[	[	X
hjic-87	85	39	29	29	NUM
hjic-87	85	40	]	]	PUNCT
hjic-87	85	41	avidin	avidin	NOUN
hjic-87	85	42	pla	pla	NOUN
hjic-87	85	43	solid	solid	ADJ
hjic-87	85	44	solution	solution	NOUN
hjic-87	85	45	[	[	X
hjic-87	85	46	28	28	NUM
hjic-87	85	47	]	]	X
hjic-87	85	48	avidin	avidin	NOUN
hjic-87	85	49	pla	pla	PROPN
hjic-87	85	50	-	-	PUNCT
hjic-87	85	51	peg	peg	NOUN
hjic-87	85	52	-	-	PUNCT
hjic-87	85	53	biotin	biotin	NOUN
hjic-87	85	54	protein	protein	NOUN
hjic-87	85	55	-	-	PUNCT
hjic-87	85	56	loaded	load	VERB
hjic-87	85	57	particles	particle	NOUN
hjic-87	85	58	[	[	X
hjic-87	85	59	26	26	NUM
hjic-87	85	60	]	]	PUNCT
hjic-87	85	61	rhbmp-2b	rhbmp-2b	NOUN
hjic-87	85	62	pla	pla	NOUN
hjic-87	85	63	porous	porous	ADJ
hjic-87	85	64	scaffolds	scaffold	NOUN
hjic-87	85	65	[	[	X
hjic-87	85	66	25	25	NUM
hjic-87	85	67	]	]	PUNCT
hjic-87	85	68	ribonuclease	ribonuclease	NOUN
hjic-87	85	69	a	a	DET
hjic-87	85	70	lysozyme	lysozyme	NOUN
hjic-87	85	71	pla	pla	NOUN
hjic-87	85	72	protein	protein	NOUN
hjic-87	85	73	-	-	PUNCT
hjic-87	85	74	loaded	load	VERB
hjic-87	85	75	particles	particle	NOUN
hjic-87	85	76	,	,	PUNCT
hjic-87	85	77	10	10	NUM
hjic-87	85	78	300	300	NUM
hjic-87	85	79	µm	µm	ADP
hjic-87	85	80	[	[	X
hjic-87	85	81	27	27	NUM
hjic-87	85	82	]	]	X
hjic-87	85	83	theophylline	theophylline	ADJ
hjic-87	85	84	hpoc	hpoc	NOUN
hjic-87	85	85	microcapsules	microcapsule	NOUN
hjic-87	85	86	,	,	PUNCT
hjic-87	85	87	2,5	2,5	NUM
hjic-87	85	88	3	3	NUM
hjic-87	85	89	µm	µm	ADP
hjic-87	85	90	[	[	X
hjic-87	85	91	31	31	NUM
hjic-87	85	92	]	]	PUNCT
hjic-87	85	93	a	a	DET
hjic-87	85	94	infectious	infectious	ADJ
hjic-87	85	95	bursal	bursal	NOUN
hjic-87	85	96	disease	disease	NOUN
hjic-87	85	97	virus	virus	NOUN
hjic-87	85	98	;	;	PUNCT
hjic-87	85	99	b	b	X
hjic-87	85	100	growth	growth	NOUN
hjic-87	85	101	factor	factor	NOUN
hjic-87	85	102	recombinant	recombinant	ADJ
hjic-87	85	103	human	human	ADJ
hjic-87	85	104	bonemorphogenetic	bonemorphogenetic	PROPN
hjic-87	85	105	protein-2	protein-2	PROPN
hjic-87	85	106	;	;	PUNCT
hjic-87	85	107	c	c	NUM
hjic-87	85	108	hydrogenated	hydrogenate	VERB
hjic-87	85	109	palm	palm	NOUN
hjic-87	85	110	oil	oil	NOUN
hjic-87	85	111	;	;	PUNCT
hjic-87	85	112	gas	gas	NOUN
hjic-87	85	113	antisolvent	antisolvent	NOUN
hjic-87	85	114	(	(	PUNCT
hjic-87	85	115	gas	gas	NOUN
hjic-87	85	116	)	)	PUNCT
hjic-87	85	117	when	when	SCONJ
hjic-87	85	118	a	a	DET
hjic-87	85	119	gas	gas	NOUN
hjic-87	85	120	is	be	AUX
hjic-87	85	121	absorbed	absorb	VERB
hjic-87	85	122	in	in	ADP
hjic-87	85	123	a	a	DET
hjic-87	85	124	solution	solution	NOUN
hjic-87	85	125	this	this	DET
hjic-87	85	126	latter	latter	ADV
hjic-87	85	127	gradually	gradually	ADV
hjic-87	85	128	expands	expand	VERB
hjic-87	85	129	and	and	CCONJ
hjic-87	85	130	losses	losse	VERB
hjic-87	85	131	its	its	PRON
hjic-87	85	132	solvent	solvent	NOUN
hjic-87	85	133	strength	strength	NOUN
hjic-87	85	134	.	.	PUNCT
hjic-87	86	1	this	this	DET
hjic-87	86	2	sudden	sudden	ADJ
hjic-87	86	3	drop	drop	NOUN
hjic-87	86	4	in	in	ADP
hjic-87	86	5	solvent	solvent	ADJ
hjic-87	86	6	strength	strength	NOUN
hjic-87	86	7	leads	lead	VERB
hjic-87	86	8	to	to	ADP
hjic-87	86	9	the	the	DET
hjic-87	86	10	precipitation	precipitation	NOUN
hjic-87	86	11	of	of	ADP
hjic-87	86	12	dissolved	dissolve	VERB
hjic-87	86	13	substrates	substrate	NOUN
hjic-87	86	14	from	from	ADP
hjic-87	86	15	the	the	DET
hjic-87	86	16	supersaturated	supersaturated	ADJ
hjic-87	86	17	solution	solution	NOUN
hjic-87	86	18	.	.	PUNCT
hjic-87	87	1	gas	gas	NOUN
hjic-87	87	2	process	process	NOUN
hjic-87	87	3	claims	claim	VERB
hjic-87	87	4	a	a	DET
hjic-87	87	5	precipitator	precipitator	NOUN
hjic-87	87	6	,	,	PUNCT
hjic-87	87	7	which	which	PRON
hjic-87	87	8	is	be	AUX
hjic-87	87	9	partially	partially	ADV
hjic-87	87	10	filled	fill	VERB
hjic-87	87	11	with	with	ADP
hjic-87	87	12	the	the	DET
hjic-87	87	13	solution	solution	NOUN
hjic-87	87	14	of	of	ADP
hjic-87	87	15	api	api	NOUN
hjic-87	87	16	(	(	PUNCT
hjic-87	87	17	and	and	CCONJ
hjic-87	87	18	excipient	excipient	ADJ
hjic-87	87	19	)	)	PUNCT
hjic-87	87	20	.	.	PUNCT
hjic-87	88	1	the	the	DET
hjic-87	88	2	supercritical	supercritical	ADJ
hjic-87	88	3	fluid	fluid	NOUN
hjic-87	88	4	is	be	AUX
hjic-87	88	5	preferably	preferably	ADV
hjic-87	88	6	introduced	introduce	VERB
hjic-87	88	7	at	at	ADP
hjic-87	88	8	the	the	DET
hjic-87	88	9	bottom	bottom	NOUN
hjic-87	88	10	to	to	PART
hjic-87	88	11	achieve	achieve	VERB
hjic-87	88	12	a	a	DET
hjic-87	88	13	better	well	ADJ
hjic-87	88	14	mixing	mixing	NOUN
hjic-87	88	15	.	.	PUNCT
hjic-87	89	1	unlike	unlike	ADP
hjic-87	89	2	the	the	DET
hjic-87	89	3	other	other	ADJ
hjic-87	89	4	antisolvent	antisolvent	NOUN
hjic-87	89	5	processes	process	NOUN
hjic-87	89	6	described	describe	VERB
hjic-87	89	7	later	later	ADV
hjic-87	89	8	,	,	PUNCT
hjic-87	89	9	in	in	ADP
hjic-87	89	10	that	that	DET
hjic-87	89	11	case	case	NOUN
hjic-87	89	12	the	the	DET
hjic-87	89	13	liquid	liquid	ADJ
hjic-87	89	14	phase	phase	NOUN
hjic-87	89	15	is	be	AUX
hjic-87	89	16	the	the	DET
hjic-87	89	17	continuous	continuous	ADJ
hjic-87	89	18	one	one	NUM
hjic-87	89	19	and	and	CCONJ
hjic-87	89	20	the	the	DET
hjic-87	89	21	antisolvent	antisolvent	NOUN
hjic-87	89	22	constitutes	constitute	VERB
hjic-87	89	23	the	the	DET
hjic-87	89	24	dispersed	disperse	VERB
hjic-87	89	25	phase	phase	NOUN
hjic-87	89	26	.	.	PUNCT
hjic-87	90	1	when	when	SCONJ
hjic-87	90	2	precipitation	precipitation	NOUN
hjic-87	90	3	is	be	AUX
hjic-87	90	4	complete	complete	ADJ
hjic-87	90	5	particles	particle	NOUN
hjic-87	90	6	are	be	AUX
hjic-87	90	7	washed	wash	VERB
hjic-87	90	8	in	in	ADP
hjic-87	90	9	pure	pure	ADJ
hjic-87	90	10	scf	scf	PROPN
hjic-87	90	11	.	.	PUNCT
hjic-87	91	1	among	among	ADP
hjic-87	91	2	the	the	DET
hjic-87	91	3	related	related	ADJ
hjic-87	91	4	patents	patent	NOUN
hjic-87	91	5	the	the	DET
hjic-87	91	6	one	one	NUM
hjic-87	91	7	of	of	ADP
hjic-87	91	8	krukonis	krukonis	PROPN
hjic-87	91	9	et	et	PROPN
hjic-87	91	10	al	al	PROPN
hjic-87	91	11	.	.	PROPN
hjic-87	91	12	represents	represent	VERB
hjic-87	91	13	the	the	DET
hjic-87	91	14	most	most	ADV
hjic-87	91	15	what	what	PRON
hjic-87	91	16	we	we	PRON
hjic-87	91	17	call	call	VERB
hjic-87	91	18	gas	gas	NOUN
hjic-87	91	19	process	process	NOUN
hjic-87	91	20	[	[	X
hjic-87	91	21	32	32	NUM
hjic-87	91	22	]	]	PUNCT
hjic-87	91	23	.	.	PUNCT
hjic-87	92	1	authors	author	NOUN
hjic-87	92	2	described	describe	VERB
hjic-87	92	3	crystallization	crystallization	NOUN
hjic-87	92	4	of	of	ADP
hjic-87	92	5	two	two	NUM
hjic-87	92	6	difficult	difficult	ADJ
hjic-87	92	7	to	to	PART
hjic-87	92	8	handle	handle	VERB
hjic-87	92	9	explosives	explosive	NOUN
hjic-87	92	10	(	(	PUNCT
hjic-87	92	11	rdx	rdx	NOUN
hjic-87	92	12	and	and	CCONJ
hjic-87	92	13	nq	nq	PROPN
hjic-87	92	14	)	)	PUNCT
hjic-87	92	15	,	,	PUNCT
hjic-87	92	16	an	an	DET
hjic-87	92	17	inorganic	inorganic	ADJ
hjic-87	92	18	salt	salt	NOUN
hjic-87	92	19	(	(	PUNCT
hjic-87	92	20	cobalt	cobalt	NOUN
hjic-87	92	21	chloride	chloride	NOUN
hjic-87	92	22	)	)	PUNCT
hjic-87	92	23	and	and	CCONJ
hjic-87	92	24	a	a	DET
hjic-87	92	25	pharmaceutical	pharmaceutical	ADJ
hjic-87	92	26	precursor	precursor	NOUN
hjic-87	92	27	(	(	PUNCT
hjic-87	92	28	saligenin	saligenin	PROPN
hjic-87	92	29	)	)	PUNCT
hjic-87	92	30	.	.	PUNCT
hjic-87	93	1	two	two	NUM
hjic-87	93	2	years	year	NOUN
hjic-87	93	3	latter	latter	ADJ
hjic-87	93	4	pallado	pallado	NOUN
hjic-87	93	5	et	et	PROPN
hjic-87	93	6	al	al	PROPN
hjic-87	93	7	.	.	PROPN
hjic-87	93	8	patented	patent	VERB
hjic-87	93	9	a	a	DET
hjic-87	93	10	gas	gas	NOUN
hjic-87	93	11	application	application	NOUN
hjic-87	93	12	whereby	whereby	SCONJ
hjic-87	93	13	microcapsules	microcapsule	NOUN
hjic-87	93	14	of	of	ADP
hjic-87	93	15	apis	apis	PROPN
hjic-87	93	16	and	and	CCONJ
hjic-87	93	17	biocompatible	biocompatible	ADJ
hjic-87	93	18	polysaccharides	polysaccharide	NOUN
hjic-87	93	19	can	can	AUX
hjic-87	93	20	be	be	AUX
hjic-87	93	21	obtained	obtain	VERB
hjic-87	93	22	[	[	PUNCT
hjic-87	93	23	33	33	NUM
hjic-87	93	24	]	]	PUNCT
hjic-87	93	25	.	.	PUNCT
hjic-87	94	1	recently	recently	ADV
hjic-87	94	2	,	,	PUNCT
hjic-87	94	3	moneghini	moneghini	PROPN
hjic-87	94	4	and	and	CCONJ
hjic-87	94	5	kikic	kikic	PROPN
hjic-87	94	6	achieved	achieve	VERB
hjic-87	94	7	a	a	DET
hjic-87	94	8	remarkable	remarkable	ADJ
hjic-87	94	9	enhancement	enhancement	NOUN
hjic-87	94	10	of	of	ADP
hjic-87	94	11	carbamazepine	carbamazepine	NOUN
hjic-87	94	12	45	45	NUM
hjic-87	94	13	dissolution	dissolution	NOUN
hjic-87	94	14	rate	rate	NOUN
hjic-87	94	15	using	use	VERB
hjic-87	94	16	peg	peg	NOUN
hjic-87	94	17	4000	4000	NUM
hjic-87	94	18	polymer	polymer	NOUN
hjic-87	94	19	in	in	ADP
hjic-87	94	20	gas	gas	NOUN
hjic-87	94	21	technology	technology	NOUN
hjic-87	94	22	[	[	X
hjic-87	94	23	34	34	NUM
hjic-87	94	24	]	]	PUNCT
hjic-87	94	25	.	.	PUNCT
hjic-87	95	1	drug	drug	NOUN
hjic-87	95	2	and	and	CCONJ
hjic-87	95	3	peg	peg	NOUN
hjic-87	95	4	4000	4000	NUM
hjic-87	95	5	particles	particle	NOUN
hjic-87	95	6	were	be	AUX
hjic-87	95	7	still	still	ADV
hjic-87	95	8	distinguishable	distinguishable	ADJ
hjic-87	95	9	at	at	ADP
hjic-87	95	10	d	d	PROPN
hjic-87	95	11	/	/	SYM
hjic-87	95	12	p	p	NOUN
hjic-87	95	13	=	=	NOUN
hjic-87	95	14	1:1,5	1:1,5	NOUN
hjic-87	95	15	.	.	PUNCT
hjic-87	96	1	at	at	ADP
hjic-87	96	2	d	d	PROPN
hjic-87	96	3	/	/	SYM
hjic-87	96	4	p	p	X
hjic-87	96	5	=	=	SYM
hjic-87	96	6	1:11	1:11	NUM
hjic-87	96	7	they	they	PRON
hjic-87	96	8	precipitated	precipitate	VERB
hjic-87	96	9	together	together	ADV
hjic-87	96	10	,	,	PUNCT
hjic-87	96	11	but	but	CCONJ
hjic-87	96	12	crystalline	crystalline	ADJ
hjic-87	96	13	drug	drug	NOUN
hjic-87	96	14	remained	remain	VERB
hjic-87	96	15	detectable	detectable	ADJ
hjic-87	96	16	.	.	PUNCT
hjic-87	97	1	corrigan	corrigan	PROPN
hjic-87	97	2	et	et	PROPN
hjic-87	97	3	al	al	PROPN
hjic-87	97	4	.	.	PROPN
hjic-87	98	1	compared	compare	VERB
hjic-87	98	2	three	three	NUM
hjic-87	98	3	formulation	formulation	NOUN
hjic-87	98	4	methods	method	NOUN
hjic-87	98	5	including	include	VERB
hjic-87	98	6	solvent	solvent	ADJ
hjic-87	98	7	evaporation	evaporation	NOUN
hjic-87	98	8	,	,	PUNCT
hjic-87	98	9	spray	spray	VERB
hjic-87	98	10	drying	dry	VERB
hjic-87	98	11	and	and	CCONJ
hjic-87	98	12	gas	gas	NOUN
hjic-87	98	13	recrystallization	recrystallization	NOUN
hjic-87	98	14	[	[	X
hjic-87	98	15	3	3	NUM
hjic-87	98	16	]	]	PUNCT
hjic-87	98	17	.	.	PUNCT
hjic-87	99	1	hydrocortisone	hydrocortisone	PROPN
hjic-87	99	2	and	and	CCONJ
hjic-87	99	3	polyvinylpyrrolidone	polyvinylpyrrolidone	PROPN
hjic-87	99	4	(	(	PUNCT
hjic-87	99	5	pvp	pvp	PROPN
hjic-87	99	6	)	)	PUNCT
hjic-87	99	7	were	be	AUX
hjic-87	99	8	coprecipitated	coprecipitate	VERB
hjic-87	99	9	in	in	ADP
hjic-87	99	10	different	different	ADJ
hjic-87	99	11	d	d	PROPN
hjic-87	99	12	/	/	SYM
hjic-87	99	13	p	p	NOUN
hjic-87	99	14	ratios	ratio	NOUN
hjic-87	99	15	.	.	PUNCT
hjic-87	100	1	it	it	PRON
hjic-87	100	2	was	be	AUX
hjic-87	100	3	found	find	VERB
hjic-87	100	4	that	that	SCONJ
hjic-87	100	5	spray	spray	NOUN
hjic-87	100	6	drying	dry	VERB
hjic-87	100	7	was	be	AUX
hjic-87	100	8	the	the	DET
hjic-87	100	9	most	most	ADV
hjic-87	100	10	effective	effective	ADJ
hjic-87	100	11	process	process	NOUN
hjic-87	100	12	for	for	ADP
hjic-87	100	13	eliminating	eliminate	VERB
hjic-87	100	14	hydrocortisone	hydrocortisone	NOUN
hjic-87	100	15	crystallinity	crystallinity	NOUN
hjic-87	100	16	,	,	PUNCT
hjic-87	100	17	followed	follow	VERB
hjic-87	100	18	by	by	ADP
hjic-87	100	19	gas	gas	NOUN
hjic-87	100	20	and	and	CCONJ
hjic-87	100	21	solvent	solvent	ADJ
hjic-87	100	22	evaporation	evaporation	NOUN
hjic-87	100	23	.	.	PUNCT
hjic-87	101	1	however	however	ADV
hjic-87	101	2	,	,	PUNCT
hjic-87	101	3	the	the	DET
hjic-87	101	4	highest	high	ADJ
hjic-87	101	5	dissolution	dissolution	ADJ
hjic-87	101	6	rate	rate	NOUN
hjic-87	101	7	was	be	AUX
hjic-87	101	8	observed	observe	VERB
hjic-87	101	9	in	in	ADP
hjic-87	101	10	the	the	DET
hjic-87	101	11	case	case	NOUN
hjic-87	101	12	of	of	ADP
hjic-87	101	13	solvent	solvent	ADJ
hjic-87	101	14	evaporation	evaporation	NOUN
hjic-87	101	15	,	,	PUNCT
hjic-87	101	16	followed	follow	VERB
hjic-87	101	17	by	by	ADP
hjic-87	101	18	spray	spray	NOUN
hjic-87	101	19	drying	dry	VERB
hjic-87	101	20	.	.	PUNCT
hjic-87	102	1	the	the	DET
hjic-87	102	2	dissolution	dissolution	NOUN
hjic-87	102	3	rates	rate	NOUN
hjic-87	102	4	of	of	ADP
hjic-87	102	5	particles	particle	NOUN
hjic-87	102	6	from	from	ADP
hjic-87	102	7	gas	gas	NOUN
hjic-87	102	8	recrystallisation	recrystallisation	NOUN
hjic-87	102	9	were	be	AUX
hjic-87	102	10	almost	almost	ADV
hjic-87	102	11	the	the	DET
hjic-87	102	12	same	same	ADJ
hjic-87	102	13	as	as	ADP
hjic-87	102	14	those	those	PRON
hjic-87	102	15	of	of	ADP
hjic-87	102	16	physical	physical	ADJ
hjic-87	102	17	mixture	mixture	NOUN
hjic-87	102	18	of	of	ADP
hjic-87	102	19	drug	drug	NOUN
hjic-87	102	20	and	and	CCONJ
hjic-87	102	21	polymer	polymer	NOUN
hjic-87	102	22	.	.	PUNCT
hjic-87	103	1	bertucco	bertucco	PROPN
hjic-87	103	2	et	et	PROPN
hjic-87	103	3	al	al	PROPN
hjic-87	103	4	.	.	PROPN
hjic-87	103	5	described	describe	VERB
hjic-87	103	6	the	the	DET
hjic-87	103	7	encapsulation	encapsulation	NOUN
hjic-87	103	8	of	of	ADP
hjic-87	103	9	potassium	potassium	NOUN
hjic-87	103	10	chloride	chloride	NOUN
hjic-87	103	11	and	and	CCONJ
hjic-87	103	12	phenylpropanolamine	phenylpropanolamine	NOUN
hjic-87	103	13	in	in	ADP
hjic-87	103	14	various	various	ADJ
hjic-87	103	15	polymers	polymer	NOUN
hjic-87	103	16	,	,	PUNCT
hjic-87	103	17	including	include	VERB
hjic-87	103	18	hydroxypropyl	hydroxypropyl	NOUN
hjic-87	103	19	methylcellulose	methylcellulose	NOUN
hjic-87	103	20	phthalate	phthalate	NOUN
hjic-87	103	21	(	(	PUNCT
hjic-87	103	22	hp-55	hp-55	NUM
hjic-87	103	23	)	)	PUNCT
hjic-87	103	24	,	,	PUNCT
hjic-87	103	25	eudragit	eudragit	X
hjic-87	103	26	e	e	NOUN
hjic-87	103	27	and	and	CCONJ
hjic-87	103	28	ethylcellulose	ethylcellulose	PROPN
hjic-87	103	29	(	(	PUNCT
hjic-87	103	30	ec	ec	PROPN
hjic-87	103	31	)	)	PUNCT
hjic-87	104	1	[	[	X
hjic-87	104	2	35	35	NUM
hjic-87	104	3	]	]	PUNCT
hjic-87	104	4	.	.	PUNCT
hjic-87	105	1	authors	author	NOUN
hjic-87	105	2	used	use	VERB
hjic-87	105	3	a	a	DET
hjic-87	105	4	stirred	stirred	ADJ
hjic-87	105	5	precipitator	precipitator	NOUN
hjic-87	105	6	in	in	ADP
hjic-87	105	7	batch	batch	NOUN
hjic-87	105	8	mode	mode	NOUN
hjic-87	105	9	.	.	PUNCT
hjic-87	106	1	polymer	polymer	NOUN
hjic-87	106	2	concentration	concentration	NOUN
hjic-87	106	3	was	be	AUX
hjic-87	106	4	found	find	VERB
hjic-87	106	5	to	to	PART
hjic-87	106	6	have	have	VERB
hjic-87	106	7	strong	strong	ADJ
hjic-87	106	8	influence	influence	NOUN
hjic-87	106	9	on	on	ADP
hjic-87	106	10	particle	particle	NOUN
hjic-87	106	11	morphology	morphology	NOUN
hjic-87	106	12	:	:	PUNCT
hjic-87	106	13	at	at	ADP
hjic-87	106	14	low	low	ADJ
hjic-87	106	15	concentration	concentration	NOUN
hjic-87	106	16	only	only	ADV
hjic-87	106	17	partial	partial	ADJ
hjic-87	106	18	encapsulation	encapsulation	NOUN
hjic-87	106	19	was	be	AUX
hjic-87	106	20	observed	observe	VERB
hjic-87	106	21	,	,	PUNCT
hjic-87	106	22	at	at	ADP
hjic-87	106	23	high	high	ADJ
hjic-87	106	24	polymer	polymer	NOUN
hjic-87	106	25	concentration	concentration	NOUN
hjic-87	106	26	particles	particle	NOUN
hjic-87	106	27	were	be	AUX
hjic-87	106	28	aggregated	aggregate	VERB
hjic-87	106	29	.	.	PUNCT
hjic-87	107	1	in	in	ADP
hjic-87	107	2	a	a	DET
hjic-87	107	3	previous	previous	ADJ
hjic-87	107	4	study	study	NOUN
hjic-87	107	5	bertucco	bertucco	NOUN
hjic-87	107	6	et	et	PROPN
hjic-87	107	7	al	al	PROPN
hjic-87	107	8	.	.	PROPN
hjic-87	107	9	prepared	prepared	PROPN
hjic-87	107	10	controlled	control	VERB
hjic-87	107	11	release	release	NOUN
hjic-87	107	12	particles	particle	NOUN
hjic-87	107	13	of	of	ADP
hjic-87	107	14	two	two	NUM
hjic-87	107	15	steroids	steroid	NOUN
hjic-87	107	16	and	and	CCONJ
hjic-87	107	17	a	a	DET
hjic-87	107	18	protein	protein	NOUN
hjic-87	107	19	embedded	embed	VERB
hjic-87	107	20	in	in	ADP
hjic-87	107	21	hyaff-11	hyaff-11	PROPN
hjic-87	107	22	(	(	PUNCT
hjic-87	107	23	hyaluronic	hyaluronic	ADJ
hjic-87	107	24	acid	acid	NOUN
hjic-87	107	25	benzylic	benzylic	NOUN
hjic-87	107	26	ester	ester	NOUN
hjic-87	107	27	)	)	PUNCT
hjic-87	107	28	polymer	polymer	NOUN
hjic-87	107	29	[	[	X
hjic-87	107	30	36	36	NUM
hjic-87	107	31	]	]	PUNCT
hjic-87	107	32	.	.	PUNCT
hjic-87	108	1	although	although	SCONJ
hjic-87	108	2	,	,	PUNCT
hjic-87	108	3	the	the	DET
hjic-87	108	4	authors	author	NOUN
hjic-87	108	5	called	call	VERB
hjic-87	108	6	their	their	PRON
hjic-87	108	7	process	process	NOUN
hjic-87	108	8	supercritical	supercritical	ADJ
hjic-87	108	9	anti	anti	ADJ
hjic-87	108	10	-	-	ADJ
hjic-87	108	11	solvent	solvent	ADJ
hjic-87	108	12	,	,	PUNCT
hjic-87	108	13	it	it	PRON
hjic-87	108	14	corresponds	correspond	VERB
hjic-87	108	15	much	much	ADV
hjic-87	108	16	more	more	ADJ
hjic-87	108	17	to	to	ADP
hjic-87	108	18	gas	gas	NOUN
hjic-87	108	19	,	,	PUNCT
hjic-87	108	20	in	in	ADP
hjic-87	108	21	our	our	PRON
hjic-87	108	22	nomenclature	nomenclature	NOUN
hjic-87	108	23	.	.	PUNCT
hjic-87	109	1	they	they	PRON
hjic-87	109	2	obtained	obtain	VERB
hjic-87	109	3	particles	particle	NOUN
hjic-87	109	4	with	with	ADP
hjic-87	109	5	an	an	DET
hjic-87	109	6	average	average	ADJ
hjic-87	109	7	diameter	diameter	NOUN
hjic-87	109	8	of	of	ADP
hjic-87	109	9	around	around	ADV
hjic-87	109	10	4	4	NUM
hjic-87	109	11	µm	µm	NOUN
hjic-87	109	12	.	.	PUNCT
hjic-87	110	1	however	however	ADV
hjic-87	110	2	,	,	PUNCT
hjic-87	110	3	yields	yield	NOUN
hjic-87	110	4	were	be	AUX
hjic-87	110	5	rather	rather	ADV
hjic-87	110	6	poor	poor	ADJ
hjic-87	110	7	for	for	ADP
hjic-87	110	8	steroids	steroid	NOUN
hjic-87	110	9	due	due	ADP
hjic-87	110	10	to	to	ADP
hjic-87	110	11	their	their	PRON
hjic-87	110	12	nonnegligible	nonnegligible	ADJ
hjic-87	110	13	solubilities	solubility	NOUN
hjic-87	110	14	in	in	ADP
hjic-87	110	15	scco2	scco2	PROPN
hjic-87	110	16	.	.	PUNCT
hjic-87	111	1	table	table	NOUN
hjic-87	111	2	3	3	NUM
hjic-87	111	3	summary	summary	NOUN
hjic-87	111	4	of	of	ADP
hjic-87	111	5	drug	drug	NOUN
hjic-87	111	6	-	-	PUNCT
hjic-87	111	7	carrier	carrier	NOUN
hjic-87	111	8	systems	system	NOUN
hjic-87	111	9	precipitated	precipitate	VERB
hjic-87	111	10	by	by	ADP
hjic-87	111	11	gas	gas	NOUN
hjic-87	111	12	and	and	CCONJ
hjic-87	111	13	related	related	ADJ
hjic-87	111	14	methods	method	NOUN
hjic-87	111	15	.	.	PUNCT
hjic-87	112	1	substrate	substrate	NOUN
hjic-87	112	2	excipient	excipient	ADJ
hjic-87	112	3	observation	observation	NOUN
hjic-87	112	4	references	reference	NOUN
hjic-87	112	5	insulin	insulin	NOUN
hjic-87	112	6	calcitonin	calcitonin	ADJ
hjic-87	112	7	gmscfd	gmscfd	NOUN
hjic-87	112	8	hyaff-7a	hyaff-7a	PUNCT
hjic-87	112	9	hyaff-11b	hyaff-11b	VERB
hjic-87	112	10	hyaff-11	hyaff-11	NOUN
hjic-87	112	11	-	-	PUNCT
hjic-87	112	12	p75c	p75c	NOUN
hjic-87	112	13	mean	mean	NOUN
hjic-87	112	14	particle	particle	NOUN
hjic-87	112	15	size	size	NOUN
hjic-87	112	16	:	:	PUNCT
hjic-87	112	17	0,1	0,1	NUM
hjic-87	112	18	1	1	NUM
hjic-87	112	19	µm	µm	ADP
hjic-87	112	20	[	[	NOUN
hjic-87	112	21	33	33	NUM
hjic-87	112	22	]	]	X
hjic-87	112	23	steroids	steroid	VERB
hjic-87	112	24	hyaff-11	hyaff-11	PROPN
hjic-87	113	1	[	[	X
hjic-87	113	2	36	36	NUM
hjic-87	113	3	]	]	X
hjic-87	113	4	kcl	kcl	PROPN
hjic-87	113	5	phenylpropanol	phenylpropanol	NOUN
hjic-87	113	6	-	-	PUNCT
hjic-87	113	7	amine	amine	NOUN
hjic-87	113	8	hp-55	hp-55	X
hjic-87	113	9	eudragit	eudragit	X
hjic-87	113	10	e100	e100	PROPN
hjic-87	113	11	ec	ec	PROPN
hjic-87	113	12	mean	mean	VERB
hjic-87	113	13	particle	particle	NOUN
hjic-87	113	14	size	size	NOUN
hjic-87	113	15	:	:	PUNCT
hjic-87	113	16	500	500	NUM
hjic-87	113	17	nm	nm	NOUN
hjic-87	113	18	[	[	X
hjic-87	113	19	35	35	NUM
hjic-87	113	20	]	]	PUNCT
hjic-87	113	21	carbamazepine	carbamazepine	NOUN
hjic-87	113	22	peg	peg	NOUN
hjic-87	113	23	4000	4000	NUM
hjic-87	113	24	heterogeneous	heterogeneous	ADJ
hjic-87	113	25	precipitate	precipitate	NOUN
hjic-87	113	26	[	[	X
hjic-87	113	27	34	34	NUM
hjic-87	113	28	]	]	X
hjic-87	113	29	hydrocortisone	hydrocortisone	PROPN
hjic-87	113	30	pvp	pvp	PROPN
hjic-87	113	31	particles	particle	NOUN
hjic-87	113	32	with	with	ADP
hjic-87	113	33	crystalline	crystalline	ADJ
hjic-87	113	34	substrate	substrate	NOUN
hjic-87	113	35	[	[	X
hjic-87	113	36	3	3	NUM
hjic-87	113	37	]	]	PUNCT
hjic-87	113	38	carbamazepine	carbamazepine	NOUN
hjic-87	113	39	peg	peg	NOUN
hjic-87	113	40	4000	4000	NUM
hjic-87	113	41	theophylline	theophylline	ADJ
hjic-87	113	42	hpmc	hpmc	ADJ
hjic-87	113	43	solid	solid	ADJ
hjic-87	113	44	dispersion	dispersion	NOUN
hjic-87	113	45	[	[	X
hjic-87	113	46	37	37	NUM
hjic-87	113	47	]	]	PUNCT
hjic-87	113	48	carbamazepine	carbamazepine	NOUN
hjic-87	113	49	peg	peg	NOUN
hjic-87	113	50	8000	8000	NUM
hjic-87	113	51	gelucire	gelucire	NOUN
hjic-87	113	52	44/14	44/14	NUM
hjic-87	113	53	vitamin	vitamin	NOUN
hjic-87	113	54	e	e	NOUN
hjic-87	113	55	tpgs	tpgs	NOUN
hjic-87	113	56	e	e	X
hjic-87	113	57	solid	solid	ADJ
hjic-87	113	58	dispersion	dispersion	NOUN
hjic-87	113	59	[	[	X
hjic-87	113	60	38	38	NUM
hjic-87	113	61	]	]	PUNCT
hjic-87	113	62	carbamazepine	carbamazepine	NOUN
hjic-87	113	63	pvp	pvp	PROPN
hjic-87	113	64	k30	k30	PROPN
hjic-87	113	65	gelucire	gelucire	VERB
hjic-87	113	66	44/14	44/14	NUM
hjic-87	113	67	vitamin	vitamin	NOUN
hjic-87	113	68	e	e	X
hjic-87	113	69	tpgs	tpgs	NOUN
hjic-87	113	70	solid	solid	ADJ
hjic-87	113	71	dispersion	dispersion	NOUN
hjic-87	113	72	[	[	X
hjic-87	113	73	39	39	NUM
hjic-87	113	74	]	]	PUNCT
hjic-87	113	75	a	a	DET
hjic-87	113	76	ethyl	ethyl	PROPN
hjic-87	113	77	ester	ester	NOUN
hjic-87	113	78	of	of	ADP
hjic-87	113	79	hyaluronic	hyaluronic	ADJ
hjic-87	113	80	acid	acid	NOUN
hjic-87	113	81	;	;	PUNCT
hjic-87	113	82	b	b	X
hjic-87	113	83	benzyl	benzyl	NOUN
hjic-87	113	84	ester	ester	NOUN
hjic-87	113	85	of	of	ADP
hjic-87	113	86	hyaluronic	hyaluronic	ADJ
hjic-87	113	87	acid	acid	NOUN
hjic-87	113	88	;	;	PUNCT
hjic-87	113	89	c	c	X
hjic-87	113	90	partial	partial	ADJ
hjic-87	113	91	benzyl	benzyl	NOUN
hjic-87	113	92	ester	ester	NOUN
hjic-87	113	93	of	of	ADP
hjic-87	113	94	hyaluronic	hyaluronic	ADJ
hjic-87	113	95	acid	acid	NOUN
hjic-87	113	96	;	;	PUNCT
hjic-87	113	97	d	d	X
hjic-87	113	98	granulocyte	granulocyte	ADJ
hjic-87	113	99	macrophage	macrophage	ADJ
hjic-87	113	100	colony	colony	NOUN
hjic-87	113	101	stimulating	stimulate	VERB
hjic-87	113	102	factor	factor	NOUN
hjic-87	113	103	;	;	PUNCT
hjic-87	113	104	e	e	X
hjic-87	113	105	d	d	PROPN
hjic-87	113	106	-	-	PUNCT
hjic-87	113	107	α	α	DET
hjic-87	113	108	-	-	ADJ
hjic-87	113	109	tocopheryl	tocopheryl	ADJ
hjic-87	113	110	polyethylene	polyethylene	NOUN
hjic-87	113	111	glycol	glycol	NOUN
hjic-87	113	112	1000	1000	NUM
hjic-87	113	113	succinate	succinate	NOUN
hjic-87	113	114	supercritical	supercritical	ADJ
hjic-87	113	115	antisolvent	antisolvent	NOUN
hjic-87	113	116	(	(	PUNCT
hjic-87	113	117	sas	sas	PROPN
hjic-87	113	118	)	)	PUNCT
hjic-87	113	119	aerosol	aerosol	NOUN
hjic-87	113	120	solvent	solvent	ADJ
hjic-87	113	121	extraction	extraction	NOUN
hjic-87	113	122	system	system	NOUN
hjic-87	113	123	(	(	PUNCT
hjic-87	113	124	ases	ases	PROPN
hjic-87	113	125	)	)	PUNCT
hjic-87	113	126	precipitation	precipitation	NOUN
hjic-87	113	127	with	with	ADP
hjic-87	113	128	a	a	DET
hjic-87	113	129	compressed	compress	VERB
hjic-87	113	130	fluid	fluid	ADJ
hjic-87	113	131	antisolvent	antisolvent	NOUN
hjic-87	113	132	(	(	PUNCT
hjic-87	113	133	pca	pca	PROPN
hjic-87	113	134	)	)	PUNCT
hjic-87	113	135	sas	sas	PROPN
hjic-87	113	136	(	(	PUNCT
hjic-87	113	137	ases	ases	PROPN
hjic-87	113	138	,	,	PUNCT
hjic-87	113	139	pca	pca	PROPN
hjic-87	113	140	)	)	PUNCT
hjic-87	113	141	involves	involve	VERB
hjic-87	113	142	a	a	DET
hjic-87	113	143	capillary	capillary	NOUN
hjic-87	113	144	through	through	ADP
hjic-87	113	145	which	which	PRON
hjic-87	113	146	the	the	DET
hjic-87	113	147	solution	solution	NOUN
hjic-87	113	148	of	of	ADP
hjic-87	113	149	api	api	NOUN
hjic-87	113	150	is	be	AUX
hjic-87	113	151	dispersed	disperse	VERB
hjic-87	113	152	in	in	ADP
hjic-87	113	153	a	a	DET
hjic-87	113	154	continuous	continuous	ADJ
hjic-87	113	155	scf	scf	NOUN
hjic-87	113	156	flow	flow	NOUN
hjic-87	113	157	.	.	PUNCT
hjic-87	114	1	the	the	DET
hjic-87	114	2	nomenclature	nomenclature	NOUN
hjic-87	114	3	is	be	AUX
hjic-87	114	4	not	not	PART
hjic-87	114	5	consistent	consistent	ADJ
hjic-87	114	6	at	at	ADP
hjic-87	114	7	this	this	DET
hjic-87	114	8	point	point	NOUN
hjic-87	114	9	;	;	PUNCT
hjic-87	114	10	certain	certain	ADJ
hjic-87	114	11	authors	author	NOUN
hjic-87	114	12	use	use	VERB
hjic-87	114	13	the	the	DET
hjic-87	114	14	name	name	NOUN
hjic-87	114	15	of	of	ADP
hjic-87	114	16	sas	sas	PROPN
hjic-87	114	17	as	as	ADP
hjic-87	114	18	a	a	DET
hjic-87	114	19	synonym	synonym	NOUN
hjic-87	114	20	of	of	ADP
hjic-87	114	21	gas	gas	NOUN
hjic-87	114	22	.	.	PUNCT
hjic-87	115	1	in	in	ADP
hjic-87	115	2	this	this	DET
hjic-87	115	3	work	work	NOUN
hjic-87	115	4	sas	sas	PROPN
hjic-87	115	5	(	(	PUNCT
hjic-87	115	6	ases	ases	PROPN
hjic-87	115	7	,	,	PUNCT
hjic-87	115	8	pca	pca	PROPN
hjic-87	115	9	)	)	PUNCT
hjic-87	115	10	signifies	signify	VERB
hjic-87	115	11	the	the	DET
hjic-87	115	12	process	process	NOUN
hjic-87	115	13	wherein	wherein	SCONJ
hjic-87	115	14	the	the	DET
hjic-87	115	15	solution	solution	NOUN
hjic-87	115	16	is	be	AUX
hjic-87	115	17	dispersed	disperse	VERB
hjic-87	115	18	in	in	ADP
hjic-87	115	19	the	the	DET
hjic-87	115	20	supercritical	supercritical	ADJ
hjic-87	115	21	fluid	fluid	NOUN
hjic-87	115	22	or	or	CCONJ
hjic-87	115	23	compressed	compress	VERB
hjic-87	115	24	gas	gas	NOUN
hjic-87	115	25	by	by	ADP
hjic-87	115	26	spraying	spray	VERB
hjic-87	115	27	through	through	ADP
hjic-87	115	28	a	a	DET
hjic-87	115	29	capillary	capillary	ADJ
hjic-87	115	30	nozzle	nozzle	NOUN
hjic-87	115	31	in	in	ADP
hjic-87	115	32	a	a	DET
hjic-87	115	33	co	co	ADJ
hjic-87	115	34	-	-	ADJ
hjic-87	115	35	current	current	ADJ
hjic-87	115	36	gas	gas	NOUN
hjic-87	115	37	anti	anti	ADJ
hjic-87	115	38	-	-	ADJ
hjic-87	115	39	solvent	solvent	ADJ
hjic-87	115	40	flow	flow	NOUN
hjic-87	115	41	.	.	PUNCT
hjic-87	116	1	the	the	DET
hjic-87	116	2	main	main	ADJ
hjic-87	116	3	advantage	advantage	NOUN
hjic-87	116	4	of	of	ADP
hjic-87	116	5	sas	sas	PROPN
hjic-87	116	6	over	over	ADP
hjic-87	116	7	gas	gas	NOUN
hjic-87	116	8	is	be	AUX
hjic-87	116	9	the	the	DET
hjic-87	116	10	faster	fast	ADJ
hjic-87	116	11	expansion	expansion	NOUN
hjic-87	116	12	in	in	ADP
hjic-87	116	13	steady	steady	ADJ
hjic-87	116	14	state	state	NOUN
hjic-87	116	15	conditions	condition	NOUN
hjic-87	116	16	,	,	PUNCT
hjic-87	116	17	which	which	PRON
hjic-87	116	18	results	result	VERB
hjic-87	116	19	in	in	ADP
hjic-87	116	20	higher	high	ADJ
hjic-87	116	21	nucleation	nucleation	NOUN
hjic-87	116	22	rate	rate	NOUN
hjic-87	116	23	,	,	PUNCT
hjic-87	116	24	and	and	CCONJ
hjic-87	116	25	hence	hence	ADV
hjic-87	116	26	smaller	small	ADJ
hjic-87	116	27	mean	mean	ADJ
hjic-87	116	28	particle	particle	NOUN
hjic-87	116	29	size	size	NOUN
hjic-87	116	30	and	and	CCONJ
hjic-87	116	31	narrower	narrow	ADJ
hjic-87	116	32	size	size	NOUN
hjic-87	116	33	distribution	distribution	NOUN
hjic-87	116	34	.	.	PUNCT
hjic-87	117	1	in	in	ADP
hjic-87	117	2	addition	addition	NOUN
hjic-87	117	3	,	,	PUNCT
hjic-87	117	4	physical	physical	ADJ
hjic-87	117	5	properties	property	NOUN
hjic-87	117	6	of	of	ADP
hjic-87	117	7	processed	process	VERB
hjic-87	117	8	powder	powder	NOUN
hjic-87	117	9	46	46	NUM
hjic-87	117	10	can	can	AUX
hjic-87	117	11	be	be	AUX
hjic-87	117	12	easily	easily	ADV
hjic-87	117	13	optimized	optimize	VERB
hjic-87	117	14	by	by	ADP
hjic-87	117	15	controlling	control	VERB
hjic-87	117	16	the	the	DET
hjic-87	117	17	operating	operate	VERB
hjic-87	117	18	parameters	parameter	NOUN
hjic-87	117	19	like	like	ADP
hjic-87	117	20	scf	scf	PROPN
hjic-87	117	21	flow	flow	NOUN
hjic-87	117	22	rate	rate	NOUN
hjic-87	117	23	,	,	PUNCT
hjic-87	117	24	solution	solution	NOUN
hjic-87	117	25	flow	flow	NOUN
hjic-87	117	26	rate	rate	NOUN
hjic-87	117	27	,	,	PUNCT
hjic-87	117	28	nozzle	nozzle	NOUN
hjic-87	117	29	diameter	diameter	NOUN
hjic-87	117	30	,	,	PUNCT
hjic-87	117	31	pressure	pressure	NOUN
hjic-87	117	32	and	and	CCONJ
hjic-87	117	33	temperature	temperature	NOUN
hjic-87	117	34	.	.	PUNCT
hjic-87	118	1	fisher	fisher	PROPN
hjic-87	118	2	and	and	CCONJ
hjic-87	118	3	müller	müller	PROPN
hjic-87	118	4	patented	patent	VERB
hjic-87	118	5	a	a	DET
hjic-87	118	6	coprecipitation	coprecipitation	NOUN
hjic-87	118	7	process	process	NOUN
hjic-87	118	8	wherein	wherein	SCONJ
hjic-87	118	9	a	a	DET
hjic-87	118	10	solution	solution	NOUN
hjic-87	118	11	containing	contain	VERB
hjic-87	118	12	an	an	DET
hjic-87	118	13	active	active	ADJ
hjic-87	118	14	substrate	substrate	NOUN
hjic-87	118	15	,	,	PUNCT
hjic-87	118	16	an	an	DET
hjic-87	118	17	excipient	excipient	NOUN
hjic-87	118	18	or	or	CCONJ
hjic-87	118	19	both	both	PRON
hjic-87	118	20	is	be	AUX
hjic-87	118	21	dispersed	disperse	VERB
hjic-87	118	22	in	in	ADP
hjic-87	118	23	a	a	DET
hjic-87	118	24	scf	scf	NOUN
hjic-87	118	25	flow	flow	NOUN
hjic-87	118	26	optionally	optionally	ADV
hjic-87	118	27	containing	contain	VERB
hjic-87	118	28	the	the	DET
hjic-87	118	29	excipient	excipient	ADJ
hjic-87	118	30	,	,	PUNCT
hjic-87	118	31	active	active	ADJ
hjic-87	118	32	substrate	substrate	NOUN
hjic-87	118	33	or	or	CCONJ
hjic-87	118	34	both	both	PRON
hjic-87	118	35	[	[	X
hjic-87	118	36	40	40	NUM
hjic-87	118	37	]	]	PUNCT
hjic-87	118	38	.	.	PUNCT
hjic-87	119	1	authors	author	NOUN
hjic-87	119	2	used	use	VERB
hjic-87	119	3	both	both	DET
hjic-87	119	4	single	single	ADJ
hjic-87	119	5	and	and	CCONJ
hjic-87	119	6	multi	multi	ADJ
hjic-87	119	7	-	-	ADJ
hjic-87	119	8	nozzle	nozzle	NOUN
hjic-87	119	9	injection	injection	NOUN
hjic-87	119	10	device	device	NOUN
hjic-87	119	11	and	and	CCONJ
hjic-87	119	12	disclosed	disclose	VERB
hjic-87	119	13	a	a	DET
hjic-87	119	14	number	number	NOUN
hjic-87	119	15	of	of	ADP
hjic-87	119	16	ways	way	NOUN
hjic-87	119	17	in	in	ADP
hjic-87	119	18	which	which	PRON
hjic-87	119	19	the	the	DET
hjic-87	119	20	fluids	fluid	NOUN
hjic-87	119	21	can	can	AUX
hjic-87	119	22	be	be	AUX
hjic-87	119	23	contacted	contact	VERB
hjic-87	119	24	with	with	ADP
hjic-87	119	25	one	one	NUM
hjic-87	119	26	another	another	DET
hjic-87	119	27	.	.	PUNCT
hjic-87	120	1	sterilizing	sterilize	VERB
hjic-87	120	2	capacity	capacity	NOUN
hjic-87	120	3	of	of	ADP
hjic-87	120	4	the	the	DET
hjic-87	120	5	invented	invent	VERB
hjic-87	120	6	method	method	NOUN
hjic-87	120	7	was	be	AUX
hjic-87	120	8	proved	prove	VERB
hjic-87	120	9	by	by	ADP
hjic-87	120	10	treating	treat	VERB
hjic-87	120	11	eight	eight	NUM
hjic-87	120	12	microorganisms	microorganism	NOUN
hjic-87	120	13	–	–	PUNCT
hjic-87	120	14	including	include	VERB
hjic-87	120	15	bacterias	bacteria	NOUN
hjic-87	120	16	,	,	PUNCT
hjic-87	120	17	fungis	fungis	NOUN
hjic-87	120	18	and	and	CCONJ
hjic-87	120	19	yeasts	yeast	NOUN
hjic-87	120	20	–	–	PUNCT
hjic-87	120	21	mixed	mix	VERB
hjic-87	120	22	with	with	ADP
hjic-87	120	23	pla	pla	NOUN
hjic-87	120	24	.	.	PUNCT
hjic-87	121	1	samples	sample	NOUN
hjic-87	121	2	were	be	AUX
hjic-87	121	3	totally	totally	ADV
hjic-87	121	4	sterile	sterile	ADJ
hjic-87	121	5	due	due	ADP
hjic-87	121	6	to	to	ADP
hjic-87	121	7	the	the	DET
hjic-87	121	8	treatment	treatment	NOUN
hjic-87	121	9	at	at	ADP
hjic-87	121	10	140	140	NUM
hjic-87	121	11	bar	bar	NOUN
hjic-87	121	12	50	50	NUM
hjic-87	121	13	°	°	NOUN
hjic-87	121	14	c	c	NOUN
hjic-87	121	15	.	.	PUNCT
hjic-87	122	1	in	in	ADP
hjic-87	122	2	another	another	DET
hjic-87	122	3	example	example	NOUN
hjic-87	122	4	,	,	PUNCT
hjic-87	122	5	clonidin	clonidin	PROPN
hjic-87	122	6	-	-	ADJ
hjic-87	122	7	hcl	hcl	PROPN
hjic-87	122	8	was	be	AUX
hjic-87	122	9	coprecipitated	coprecipitate	VERB
hjic-87	122	10	with	with	ADP
hjic-87	122	11	pla	pla	NOUN
hjic-87	122	12	from	from	ADP
hjic-87	122	13	dichloromethane	dichloromethane	NOUN
hjic-87	122	14	(	(	PUNCT
hjic-87	122	15	dcm	dcm	PROPN
hjic-87	122	16	)	)	PUNCT
hjic-87	122	17	.	.	PUNCT
hjic-87	123	1	in	in	ADP
hjic-87	123	2	1998	1998	NUM
hjic-87	123	3	william	william	PROPN
hjic-87	123	4	j.	j.	PROPN
hjic-87	123	5	schmitt	schmitt	PROPN
hjic-87	123	6	patented	patent	VERB
hjic-87	123	7	a	a	DET
hjic-87	123	8	similar	similar	ADJ
hjic-87	123	9	process	process	NOUN
hjic-87	123	10	.	.	PUNCT
hjic-87	124	1	his	his	PRON
hjic-87	124	2	method	method	NOUN
hjic-87	124	3	consists	consist	VERB
hjic-87	124	4	in	in	ADP
hjic-87	124	5	dissolving	dissolve	VERB
hjic-87	124	6	a	a	DET
hjic-87	124	7	solid	solid	ADJ
hjic-87	124	8	in	in	ADP
hjic-87	124	9	an	an	DET
hjic-87	124	10	appropriate	appropriate	ADJ
hjic-87	124	11	organic	organic	ADJ
hjic-87	124	12	solvent	solvent	NOUN
hjic-87	124	13	and	and	CCONJ
hjic-87	124	14	injecting	inject	VERB
hjic-87	124	15	the	the	DET
hjic-87	124	16	solution	solution	NOUN
hjic-87	124	17	in	in	ADP
hjic-87	124	18	supercritical	supercritical	ADJ
hjic-87	124	19	fluid	fluid	ADJ
hjic-87	124	20	anti	anti	ADJ
hjic-87	124	21	-	-	ADJ
hjic-87	124	22	solvent	solvent	ADJ
hjic-87	124	23	[	[	X
hjic-87	124	24	41	41	NUM
hjic-87	124	25	]	]	PUNCT
hjic-87	124	26	.	.	PUNCT
hjic-87	125	1	triamcinolone	triamcinolone	PROPN
hjic-87	125	2	acetonide	acetonide	ADJ
hjic-87	125	3	particles	particle	NOUN
hjic-87	125	4	were	be	AUX
hjic-87	125	5	precipitated	precipitate	VERB
hjic-87	125	6	from	from	ADP
hjic-87	125	7	terahydrofuran	terahydrofuran	NOUN
hjic-87	125	8	(	(	PUNCT
hjic-87	125	9	thf	thf	NOUN
hjic-87	125	10	)	)	PUNCT
hjic-87	125	11	both	both	PRON
hjic-87	125	12	in	in	ADP
hjic-87	125	13	static	static	ADJ
hjic-87	125	14	scco2	scco2	NOUN
hjic-87	125	15	and	and	CCONJ
hjic-87	125	16	continuous	continuous	ADJ
hjic-87	125	17	flow	flow	NOUN
hjic-87	125	18	with	with	ADP
hjic-87	125	19	particle	particle	NOUN
hjic-87	125	20	diameters	diameter	NOUN
hjic-87	125	21	ranging	range	VERB
hjic-87	125	22	from	from	ADP
hjic-87	125	23	10	10	NUM
hjic-87	125	24	to	to	PART
hjic-87	125	25	30	30	NUM
hjic-87	125	26	mµ	mµ	NOUN
hjic-87	125	27	and	and	CCONJ
hjic-87	125	28	from	from	ADP
hjic-87	125	29	5	5	NUM
hjic-87	125	30	to	to	PART
hjic-87	125	31	10	10	NUM
hjic-87	125	32	mµ	mµ	NOUN
hjic-87	125	33	,	,	PUNCT
hjic-87	125	34	respectively	respectively	ADV
hjic-87	125	35	.	.	PUNCT
hjic-87	126	1	also	also	ADV
hjic-87	126	2	,	,	PUNCT
hjic-87	126	3	in	in	ADP
hjic-87	126	4	1998	1998	NUM
hjic-87	126	5	,	,	PUNCT
hjic-87	126	6	manning	man	VERB
hjic-87	126	7	et	et	PROPN
hjic-87	126	8	al	al	PROPN
hjic-87	126	9	.	.	PROPN
hjic-87	126	10	patented	patent	VERB
hjic-87	126	11	a	a	DET
hjic-87	126	12	method	method	NOUN
hjic-87	126	13	,	,	PUNCT
hjic-87	126	14	which	which	PRON
hjic-87	126	15	extends	extend	VERB
hjic-87	126	16	sas	sa	VERB
hjic-87	126	17	over	over	ADP
hjic-87	126	18	hydrophilic	hydrophilic	ADJ
hjic-87	126	19	pharmaceutical	pharmaceutical	NOUN
hjic-87	126	20	substrates	substrate	NOUN
hjic-87	126	21	by	by	ADP
hjic-87	126	22	using	use	VERB
hjic-87	126	23	an	an	DET
hjic-87	126	24	amphifilic	amphifilic	ADJ
hjic-87	126	25	additive	additive	NOUN
hjic-87	126	26	[	[	X
hjic-87	126	27	42	42	NUM
hjic-87	126	28	]	]	PUNCT
hjic-87	126	29	.	.	PUNCT
hjic-87	127	1	this	this	DET
hjic-87	127	2	additive	additive	NOUN
hjic-87	127	3	–	–	PUNCT
hjic-87	127	4	preferably	preferably	ADV
hjic-87	127	5	a	a	DET
hjic-87	127	6	surfactant	surfactant	NOUN
hjic-87	127	7	–	–	PUNCT
hjic-87	127	8	forms	form	VERB
hjic-87	127	9	a	a	DET
hjic-87	127	10	hydrophobic	hydrophobic	NOUN
hjic-87	127	11	ion	ion	NOUN
hjic-87	127	12	pair	pair	NOUN
hjic-87	127	13	(	(	PUNCT
hjic-87	127	14	hip	hip	NOUN
hjic-87	127	15	)	)	PUNCT
hjic-87	127	16	complex	complex	NOUN
hjic-87	127	17	and	and	CCONJ
hjic-87	127	18	solubilizes	solubilize	VERB
hjic-87	127	19	the	the	DET
hjic-87	127	20	active	active	ADJ
hjic-87	127	21	substrate	substrate	NOUN
hjic-87	127	22	.	.	PUNCT
hjic-87	128	1	the	the	DET
hjic-87	128	2	resulting	result	VERB
hjic-87	128	3	solution	solution	NOUN
hjic-87	128	4	can	can	AUX
hjic-87	128	5	already	already	ADV
hjic-87	128	6	be	be	AUX
hjic-87	128	7	subjected	subject	VERB
hjic-87	128	8	to	to	ADP
hjic-87	128	9	any	any	DET
hjic-87	128	10	supercritical	supercritical	ADJ
hjic-87	128	11	anti	anti	ADJ
hjic-87	128	12	-	-	ADJ
hjic-87	128	13	solvent	solvent	ADJ
hjic-87	128	14	method	method	NOUN
hjic-87	128	15	.	.	PUNCT
hjic-87	129	1	falk	falk	NOUN
hjic-87	129	2	et	et	PROPN
hjic-87	130	1	al	al	PROPN
hjic-87	130	2	.	.	PROPN
hjic-87	131	1	prepared	prepared	PROPN
hjic-87	131	2	pla	pla	PROPN
hjic-87	131	3	micro	micro	PROPN
hjic-87	131	4	-	-	NOUN
hjic-87	131	5	spheres	sphere	NOUN
hjic-87	131	6	with	with	ADP
hjic-87	131	7	embedded	embed	VERB
hjic-87	131	8	apis	apis	PROPN
hjic-87	131	9	:	:	PUNCT
hjic-87	131	10	gentamycin	gentamycin	VERB
hjic-87	131	11	,	,	PUNCT
hjic-87	131	12	naltrexone	naltrexone	NOUN
hjic-87	131	13	and	and	CCONJ
hjic-87	131	14	rifampin	rifampin	VERB
hjic-87	131	15	by	by	ADP
hjic-87	131	16	pca	pca	NOUN
hjic-87	131	17	process	process	NOUN
hjic-87	131	18	[	[	X
hjic-87	131	19	43	43	NUM
hjic-87	131	20	]	]	PUNCT
hjic-87	131	21	.	.	PUNCT
hjic-87	132	1	the	the	DET
hjic-87	132	2	solution	solution	NOUN
hjic-87	132	3	containing	contain	VERB
hjic-87	132	4	both	both	CCONJ
hjic-87	132	5	the	the	DET
hjic-87	132	6	api	api	NOUN
hjic-87	132	7	and	and	CCONJ
hjic-87	132	8	the	the	DET
hjic-87	132	9	polymer	polymer	NOUN
hjic-87	132	10	was	be	AUX
hjic-87	132	11	dispersed	disperse	VERB
hjic-87	132	12	through	through	ADP
hjic-87	132	13	an	an	DET
hjic-87	132	14	ultrasonic	ultrasonic	ADJ
hjic-87	132	15	spray	spray	NOUN
hjic-87	132	16	nozzle	nozzle	NOUN
hjic-87	132	17	instead	instead	ADV
hjic-87	132	18	of	of	ADP
hjic-87	132	19	a	a	DET
hjic-87	132	20	capillary	capillary	ADJ
hjic-87	132	21	tube	tube	NOUN
hjic-87	132	22	.	.	PUNCT
hjic-87	133	1	gentamycin	gentamycin	VERB
hjic-87	133	2	and	and	CCONJ
hjic-87	133	3	naltrexone	naltrexone	NOUN
hjic-87	133	4	were	be	AUX
hjic-87	133	5	solubilised	solubilise	VERB
hjic-87	133	6	in	in	ADP
hjic-87	133	7	dcm	dcm	PROPN
hjic-87	133	8	by	by	ADP
hjic-87	133	9	hydrophobic	hydrophobic	NOUN
hjic-87	133	10	ion	ion	NOUN
hjic-87	133	11	-	-	PUNCT
hjic-87	133	12	pairing	pair	VERB
hjic-87	133	13	method	method	NOUN
hjic-87	133	14	;	;	PUNCT
hjic-87	133	15	the	the	DET
hjic-87	133	16	chosen	choose	VERB
hjic-87	133	17	surfactant	surfactant	NOUN
hjic-87	133	18	was	be	AUX
hjic-87	133	19	sodium	sodium	NOUN
hjic-87	133	20	bis-2	bis-2	NOUN
hjic-87	133	21	-	-	PUNCT
hjic-87	133	22	ethylexyl	ethylexyl	NOUN
hjic-87	133	23	sulfosuccinate	sulfosuccinate	NOUN
hjic-87	133	24	.	.	PUNCT
hjic-87	134	1	particles	particle	NOUN
hjic-87	134	2	ranged	range	VERB
hjic-87	134	3	from	from	ADP
hjic-87	134	4	0,2	0,2	NUM
hjic-87	134	5	to	to	ADP
hjic-87	134	6	1,0	1,0	NUM
hjic-87	134	7	µm	µm	NOUN
hjic-87	134	8	in	in	ADP
hjic-87	134	9	size	size	NOUN
hjic-87	134	10	,	,	PUNCT
hjic-87	134	11	drug	drug	NOUN
hjic-87	134	12	loading	loading	NOUN
hjic-87	134	13	was	be	AUX
hjic-87	134	14	higher	high	ADJ
hjic-87	134	15	for	for	ADP
hjic-87	134	16	ion	ion	NOUN
hjic-87	134	17	-	-	PUNCT
hjic-87	134	18	paired	pair	VERB
hjic-87	134	19	pharmaceuticals	pharmaceutical	NOUN
hjic-87	134	20	due	due	ADP
hjic-87	134	21	to	to	ADP
hjic-87	134	22	their	their	PRON
hjic-87	134	23	lower	low	ADJ
hjic-87	134	24	solubilities	solubility	NOUN
hjic-87	134	25	in	in	ADP
hjic-87	134	26	scco2	scco2	PROPN
hjic-87	134	27	/	/	SYM
hjic-87	134	28	dcm	dcm	PROPN
hjic-87	134	29	.	.	PUNCT
hjic-87	135	1	in	in	ADP
hjic-87	135	2	a	a	DET
hjic-87	135	3	subsequent	subsequent	ADJ
hjic-87	135	4	study	study	NOUN
hjic-87	135	5	the	the	DET
hjic-87	135	6	authors	author	NOUN
hjic-87	135	7	focused	focus	VERB
hjic-87	135	8	on	on	ADP
hjic-87	135	9	influence	influence	NOUN
hjic-87	135	10	of	of	ADP
hjic-87	135	11	process	process	NOUN
hjic-87	135	12	parameters	parameter	NOUN
hjic-87	135	13	on	on	ADP
hjic-87	135	14	residual	residual	ADJ
hjic-87	135	15	solvent	solvent	ADJ
hjic-87	135	16	level	level	NOUN
hjic-87	135	17	in	in	ADP
hjic-87	135	18	pla	pla	NOUN
hjic-87	135	19	coated	coat	VERB
hjic-87	135	20	gentamycin	gentamycin	NOUN
hjic-87	135	21	particles	particle	NOUN
hjic-87	135	22	[	[	X
hjic-87	135	23	44	44	NUM
hjic-87	135	24	]	]	PUNCT
hjic-87	135	25	.	.	PUNCT
hjic-87	136	1	residual	residual	ADJ
hjic-87	136	2	dcm	dcm	PROPN
hjic-87	136	3	content	content	NOUN
hjic-87	136	4	was	be	AUX
hjic-87	136	5	found	find	VERB
hjic-87	136	6	to	to	PART
hjic-87	136	7	decrease	decrease	VERB
hjic-87	136	8	,	,	PUNCT
hjic-87	136	9	when	when	SCONJ
hjic-87	136	10	scco2	scco2	ADJ
hjic-87	136	11	flow	flow	NOUN
hjic-87	136	12	rate	rate	NOUN
hjic-87	136	13	was	be	AUX
hjic-87	136	14	higher	high	ADJ
hjic-87	136	15	during	during	ADP
hjic-87	136	16	the	the	DET
hjic-87	136	17	precipitation	precipitation	NOUN
hjic-87	136	18	.	.	PUNCT
hjic-87	137	1	taki	taki	PROPN
hjic-87	137	2	et	et	PROPN
hjic-87	137	3	al	al	PROPN
hjic-87	137	4	.	.	PROPN
hjic-87	137	5	used	use	VERB
hjic-87	137	6	sas	sas	PROPN
hjic-87	137	7	method	method	NOUN
hjic-87	137	8	to	to	PART
hjic-87	137	9	prepare	prepare	VERB
hjic-87	137	10	controlled	control	VERB
hjic-87	137	11	release	release	NOUN
hjic-87	137	12	system	system	NOUN
hjic-87	137	13	for	for	ADP
hjic-87	137	14	the	the	DET
hjic-87	137	15	herbicide	herbicide	NOUN
hjic-87	137	16	,	,	PUNCT
hjic-87	137	17	diuron	diuron	NOUN
hjic-87	138	1	[	[	X
hjic-87	138	2	45	45	NUM
hjic-87	138	3	]	]	PUNCT
hjic-87	138	4	.	.	PUNCT
hjic-87	139	1	authors	author	NOUN
hjic-87	139	2	studied	study	VERB
hjic-87	139	3	the	the	DET
hjic-87	139	4	effect	effect	NOUN
hjic-87	139	5	of	of	ADP
hjic-87	139	6	pressure	pressure	NOUN
hjic-87	139	7	,	,	PUNCT
hjic-87	139	8	flow	flow	NOUN
hjic-87	139	9	rate	rate	NOUN
hjic-87	139	10	and	and	CCONJ
hjic-87	139	11	composition	composition	NOUN
hjic-87	139	12	on	on	ADP
hjic-87	139	13	the	the	DET
hjic-87	139	14	solid	solid	ADJ
hjic-87	139	15	dispersion	dispersion	NOUN
hjic-87	139	16	of	of	ADP
hjic-87	139	17	diuron	diuron	NOUN
hjic-87	139	18	in	in	ADP
hjic-87	139	19	pla	pla	PROPN
hjic-87	139	20	.	.	PUNCT
hjic-87	140	1	it	it	PRON
hjic-87	140	2	was	be	AUX
hjic-87	140	3	confirmed	confirm	VERB
hjic-87	140	4	that	that	SCONJ
hjic-87	140	5	the	the	DET
hjic-87	140	6	morphology	morphology	NOUN
hjic-87	140	7	of	of	ADP
hjic-87	140	8	coprecipitated	coprecipitate	VERB
hjic-87	140	9	particles	particle	NOUN
hjic-87	140	10	depends	depend	VERB
hjic-87	140	11	heavily	heavily	ADV
hjic-87	140	12	on	on	ADP
hjic-87	140	13	the	the	DET
hjic-87	140	14	concentrations	concentration	NOUN
hjic-87	140	15	of	of	ADP
hjic-87	140	16	drug	drug	NOUN
hjic-87	140	17	and	and	CCONJ
hjic-87	140	18	polymer	polymer	NOUN
hjic-87	140	19	.	.	PUNCT
hjic-87	141	1	spherical	spherical	ADJ
hjic-87	141	2	particles	particle	NOUN
hjic-87	141	3	of	of	ADP
hjic-87	141	4	pla	pla	NOUN
hjic-87	141	5	entrapping	entrap	VERB
hjic-87	141	6	diuron	diuron	NOUN
hjic-87	141	7	with	with	ADP
hjic-87	141	8	mean	mean	ADJ
hjic-87	141	9	particle	particle	NOUN
hjic-87	141	10	size	size	NOUN
hjic-87	141	11	between	between	ADP
hjic-87	141	12	1	1	NUM
hjic-87	141	13	and	and	CCONJ
hjic-87	141	14	5	5	NUM
hjic-87	141	15	µm	µm	NOUN
hjic-87	141	16	were	be	AUX
hjic-87	141	17	successfully	successfully	ADV
hjic-87	141	18	precipitated	precipitate	VERB
hjic-87	141	19	when	when	SCONJ
hjic-87	141	20	the	the	DET
hjic-87	141	21	concentrations	concentration	NOUN
hjic-87	141	22	of	of	ADP
hjic-87	141	23	diuron	diuron	NOUN
hjic-87	141	24	and	and	CCONJ
hjic-87	141	25	pla	pla	NOUN
hjic-87	141	26	were	be	AUX
hjic-87	141	27	below	below	ADP
hjic-87	141	28	0,1	0,1	NUM
hjic-87	141	29	and	and	CCONJ
hjic-87	141	30	3	3	NUM
hjic-87	141	31	%	%	NOUN
hjic-87	141	32	(	(	PUNCT
hjic-87	141	33	wt	wt	NOUN
hjic-87	141	34	.	.	PROPN
hjic-87	141	35	)	)	PUNCT
hjic-87	141	36	,	,	PUNCT
hjic-87	141	37	respectively	respectively	ADV
hjic-87	141	38	.	.	PUNCT
hjic-87	142	1	sze	sze	PROPN
hjic-87	142	2	tu	tu	PROPN
hjic-87	142	3	et	et	PROPN
hjic-87	142	4	al	al	PROPN
hjic-87	142	5	.	.	PROPN
hjic-87	142	6	studied	study	VERB
hjic-87	142	7	the	the	DET
hjic-87	142	8	effect	effect	NOUN
hjic-87	142	9	of	of	ADP
hjic-87	142	10	the	the	DET
hjic-87	142	11	main	main	ADJ
hjic-87	142	12	process	process	NOUN
hjic-87	142	13	parameters	parameter	NOUN
hjic-87	142	14	,	,	PUNCT
hjic-87	142	15	like	like	ADP
hjic-87	142	16	:	:	PUNCT
hjic-87	142	17	pressure	pressure	NOUN
hjic-87	142	18	,	,	PUNCT
hjic-87	142	19	temperature	temperature	NOUN
hjic-87	142	20	,	,	PUNCT
hjic-87	142	21	spraying	spray	VERB
hjic-87	142	22	velocity	velocity	NOUN
hjic-87	142	23	,	,	PUNCT
hjic-87	142	24	solution	solution	NOUN
hjic-87	142	25	concentration	concentration	NOUN
hjic-87	142	26	and	and	CCONJ
hjic-87	142	27	solvent	solvent	NOUN
hjic-87	142	28	strength	strength	NOUN
hjic-87	142	29	on	on	ADP
hjic-87	142	30	ases	ases	PROPN
hjic-87	142	31	-	-	PUNCT
hjic-87	142	32	precipitated	precipitate	VERB
hjic-87	142	33	pla	pla	NOUN
hjic-87	142	34	particles	particle	NOUN
hjic-87	142	35	loaded	load	VERB
hjic-87	142	36	with	with	ADP
hjic-87	142	37	para	para	ADJ
hjic-87	142	38	-	-	PUNCT
hjic-87	142	39	hydroxybenzoic	hydroxybenzoic	NOUN
hjic-87	142	40	acid	acid	NOUN
hjic-87	142	41	(	(	PUNCT
hjic-87	142	42	phba	phba	NOUN
hjic-87	142	43	)	)	PUNCT
hjic-87	142	44	and	and	CCONJ
hjic-87	142	45	lysosyme	lysosyme	NOUN
hjic-87	142	46	[	[	X
hjic-87	142	47	46,47	46,47	X
hjic-87	142	48	]	]	PUNCT
hjic-87	142	49	.	.	PUNCT
hjic-87	143	1	authors	author	NOUN
hjic-87	143	2	used	use	VERB
hjic-87	143	3	a	a	DET
hjic-87	143	4	multiple	multiple	ADJ
hjic-87	143	5	nozzle	nozzle	NOUN
hjic-87	143	6	(	(	PUNCT
hjic-87	143	7	three	three	NUM
hjic-87	143	8	-	-	PUNCT
hjic-87	143	9	passages	passage	NOUN
hjic-87	143	10	)	)	PUNCT
hjic-87	143	11	with	with	ADP
hjic-87	143	12	a	a	DET
hjic-87	143	13	capillary	capillary	ADJ
hjic-87	143	14	tube	tube	NOUN
hjic-87	143	15	of	of	ADP
hjic-87	143	16	180	180	NUM
hjic-87	143	17	µm	µm	ADP
hjic-87	143	18	i.d	i.d	PROPN
hjic-87	143	19	.	.	PROPN
hjic-87	143	20	in	in	ADP
hjic-87	143	21	the	the	DET
hjic-87	143	22	middle	middle	NOUN
hjic-87	143	23	.	.	PUNCT
hjic-87	144	1	initially	initially	ADV
hjic-87	144	2	,	,	PUNCT
hjic-87	144	3	api	api	NOUN
hjic-87	144	4	and	and	CCONJ
hjic-87	144	5	polymer	polymer	NOUN
hjic-87	144	6	were	be	AUX
hjic-87	144	7	delivered	deliver	VERB
hjic-87	144	8	in	in	ADP
hjic-87	144	9	the	the	DET
hjic-87	144	10	same	same	ADJ
hjic-87	144	11	solution	solution	NOUN
hjic-87	144	12	through	through	ADP
hjic-87	144	13	the	the	DET
hjic-87	144	14	inner	inner	ADJ
hjic-87	144	15	capillary	capillary	ADJ
hjic-87	144	16	tube	tube	NOUN
hjic-87	144	17	.	.	PUNCT
hjic-87	145	1	in	in	ADP
hjic-87	145	2	a	a	DET
hjic-87	145	3	second	second	ADJ
hjic-87	145	4	stage	stage	NOUN
hjic-87	145	5	,	,	PUNCT
hjic-87	145	6	solution	solution	NOUN
hjic-87	145	7	of	of	ADP
hjic-87	145	8	active	active	ADJ
hjic-87	145	9	substrate	substrate	NOUN
hjic-87	145	10	was	be	AUX
hjic-87	145	11	delivered	deliver	VERB
hjic-87	145	12	in	in	ADP
hjic-87	145	13	the	the	DET
hjic-87	145	14	inner	inner	ADJ
hjic-87	145	15	nozzle	nozzle	NOUN
hjic-87	145	16	and	and	CCONJ
hjic-87	145	17	the	the	DET
hjic-87	145	18	polymer	polymer	NOUN
hjic-87	145	19	in	in	ADP
hjic-87	145	20	the	the	DET
hjic-87	145	21	intermediate	intermediate	ADJ
hjic-87	145	22	passage	passage	NOUN
hjic-87	145	23	.	.	PUNCT
hjic-87	146	1	the	the	DET
hjic-87	146	2	encapsulation	encapsulation	NOUN
hjic-87	146	3	efficiency	efficiency	NOUN
hjic-87	146	4	–	–	PUNCT
hjic-87	146	5	using	use	VERB
hjic-87	146	6	the	the	DET
hjic-87	146	7	multiple	multiple	ADJ
hjic-87	146	8	nozzle	nozzle	NOUN
hjic-87	146	9	–	–	PUNCT
hjic-87	146	10	of	of	ADP
hjic-87	146	11	p	p	NOUN
hjic-87	146	12	-	-	PUNCT
hjic-87	146	13	hba	hba	NOUN
hjic-87	146	14	and	and	CCONJ
hjic-87	146	15	lysosyme	lysosyme	NOUN
hjic-87	146	16	was	be	AUX
hjic-87	146	17	8,2	8,2	NUM
hjic-87	146	18	%	%	NOUN
hjic-87	146	19	and	and	CCONJ
hjic-87	146	20	12,4	12,4	NUM
hjic-87	146	21	%	%	NOUN
hjic-87	146	22	,	,	PUNCT
hjic-87	146	23	respectively	respectively	ADV
hjic-87	146	24	.	.	PUNCT
hjic-87	147	1	average	average	ADJ
hjic-87	147	2	drug	drug	NOUN
hjic-87	147	3	loading	loading	NOUN
hjic-87	147	4	was	be	AUX
hjic-87	147	5	between	between	ADP
hjic-87	147	6	3	3	NUM
hjic-87	147	7	and	and	CCONJ
hjic-87	147	8	8	8	NUM
hjic-87	147	9	%	%	NOUN
hjic-87	147	10	(	(	PUNCT
hjic-87	147	11	wt	wt	NOUN
hjic-87	147	12	.	.	PUNCT
hjic-87	147	13	)	)	PUNCT
hjic-87	148	1	while	while	SCONJ
hjic-87	148	2	theoretical	theoretical	ADJ
hjic-87	148	3	drug	drug	NOUN
hjic-87	148	4	loading	loading	NOUN
hjic-87	148	5	was	be	AUX
hjic-87	148	6	typically	typically	ADV
hjic-87	148	7	between	between	ADP
hjic-87	148	8	60	60	NUM
hjic-87	148	9	and	and	CCONJ
hjic-87	148	10	84	84	NUM
hjic-87	148	11	%	%	NOUN
hjic-87	148	12	(	(	PUNCT
hjic-87	148	13	wt	wt	NOUN
hjic-87	148	14	.	.	PUNCT
hjic-87	148	15	)	)	PUNCT
hjic-87	148	16	.	.	PUNCT
hjic-87	149	1	solution	solution	NOUN
hjic-87	149	2	enhanced	enhance	VERB
hjic-87	149	3	dispersion	dispersion	NOUN
hjic-87	149	4	by	by	ADP
hjic-87	149	5	supercritical	supercritical	ADJ
hjic-87	149	6	fluids	fluid	NOUN
hjic-87	149	7	(	(	PUNCT
hjic-87	149	8	seds	sed	NOUN
hjic-87	149	9	)	)	PUNCT
hjic-87	149	10	seds	sed	NOUN
hjic-87	149	11	was	be	AUX
hjic-87	149	12	described	describe	VERB
hjic-87	149	13	in	in	ADP
hjic-87	149	14	sequential	sequential	ADJ
hjic-87	149	15	patents	patent	NOUN
hjic-87	149	16	associated	associate	VERB
hjic-87	149	17	with	with	ADP
hjic-87	149	18	the	the	DET
hjic-87	149	19	name	name	NOUN
hjic-87	149	20	of	of	ADP
hjic-87	149	21	the	the	DET
hjic-87	149	22	university	university	NOUN
hjic-87	149	23	of	of	ADP
hjic-87	149	24	bradford	bradford	NOUN
hjic-87	149	25	and	and	CCONJ
hjic-87	149	26	recently	recently	ADV
hjic-87	149	27	bradford	bradford	PROPN
hjic-87	149	28	particle	particle	PROPN
hjic-87	149	29	design	design	PROPN
hjic-87	149	30	plc	plc	PROPN
hjic-87	150	1	[	[	X
hjic-87	150	2	63	63	NUM
hjic-87	150	3	-	-	SYM
hjic-87	150	4	68	68	NUM
hjic-87	150	5	]	]	PUNCT
hjic-87	150	6	.	.	PUNCT
hjic-87	151	1	this	this	DET
hjic-87	151	2	method	method	NOUN
hjic-87	151	3	claims	claim	VERB
hjic-87	151	4	a	a	DET
hjic-87	151	5	coaxial	coaxial	ADJ
hjic-87	151	6	nozzle	nozzle	NOUN
hjic-87	151	7	to	to	PART
hjic-87	151	8	co	co	VERB
hjic-87	151	9	-	-	VERB
hjic-87	151	10	introduce	introduce	VERB
hjic-87	151	11	the	the	DET
hjic-87	151	12	scf	scf	NOUN
hjic-87	151	13	and	and	CCONJ
hjic-87	151	14	the	the	DET
hjic-87	151	15	solution	solution	NOUN
hjic-87	151	16	of	of	ADP
hjic-87	151	17	api	api	NOUN
hjic-87	151	18	in	in	ADP
hjic-87	151	19	the	the	DET
hjic-87	151	20	precipitation	precipitation	NOUN
hjic-87	151	21	vessel	vessel	NOUN
hjic-87	151	22	.	.	PUNCT
hjic-87	152	1	due	due	ADP
hjic-87	152	2	to	to	ADP
hjic-87	152	3	the	the	DET
hjic-87	152	4	high	high	ADJ
hjic-87	152	5	velocity	velocity	NOUN
hjic-87	152	6	of	of	ADP
hjic-87	152	7	scf	scf	PROPN
hjic-87	152	8	–	–	PUNCT
hjic-87	152	9	driven	drive	VERB
hjic-87	152	10	preferably	preferably	ADV
hjic-87	152	11	in	in	ADP
hjic-87	152	12	the	the	DET
hjic-87	152	13	inner	inner	ADJ
hjic-87	152	14	passage	passage	NOUN
hjic-87	152	15	–	–	PUNCT
hjic-87	152	16	a	a	DET
hjic-87	152	17	jet	jet	NOUN
hjic-87	152	18	is	be	AUX
hjic-87	152	19	forming	form	VERB
hjic-87	152	20	at	at	ADP
hjic-87	152	21	the	the	DET
hjic-87	152	22	outlet	outlet	NOUN
hjic-87	152	23	of	of	ADP
hjic-87	152	24	the	the	DET
hjic-87	152	25	nozzle	nozzle	NOUN
hjic-87	152	26	wherein	wherein	SCONJ
hjic-87	152	27	the	the	DET
hjic-87	152	28	scf	scf	PROPN
hjic-87	152	29	brakes	brake	NOUN
hjic-87	152	30	up	up	ADP
hjic-87	152	31	the	the	DET
hjic-87	152	32	solution	solution	NOUN
hjic-87	152	33	into	into	ADP
hjic-87	152	34	small	small	ADJ
hjic-87	152	35	droplets	droplet	NOUN
hjic-87	152	36	and	and	CCONJ
hjic-87	152	37	extracts	extract	NOUN
hjic-87	152	38	the	the	DET
hjic-87	152	39	solvent	solvent	NOUN
hjic-87	152	40	.	.	PUNCT
hjic-87	153	1	the	the	DET
hjic-87	153	2	high	high	ADJ
hjic-87	153	3	dispersion	dispersion	NOUN
hjic-87	153	4	that	that	PRON
hjic-87	153	5	characterises	characterise	VERB
hjic-87	153	6	the	the	DET
hjic-87	153	7	jet	jet	NOUN
hjic-87	153	8	leads	lead	VERB
hjic-87	153	9	to	to	ADP
hjic-87	153	10	almost	almost	ADV
hjic-87	153	11	instantaneous	instantaneous	ADJ
hjic-87	153	12	precipitation	precipitation	NOUN
hjic-87	153	13	of	of	ADP
hjic-87	153	14	micron	micron	NOUN
hjic-87	153	15	and	and	CCONJ
hjic-87	153	16	sub	sub	ADJ
hjic-87	153	17	-	-	ADJ
hjic-87	153	18	micron	micron	ADJ
hjic-87	153	19	sized	sized	ADJ
hjic-87	153	20	uniform	uniform	ADJ
hjic-87	153	21	particles	particle	NOUN
hjic-87	153	22	.	.	PUNCT
hjic-87	154	1	the	the	DET
hjic-87	154	2	main	main	ADJ
hjic-87	154	3	advantage	advantage	NOUN
hjic-87	154	4	of	of	ADP
hjic-87	154	5	seds	sed	NOUN
hjic-87	154	6	over	over	ADP
hjic-87	154	7	other	other	ADJ
hjic-87	154	8	supercritical	supercritical	ADJ
hjic-87	154	9	fluid	fluid	NOUN
hjic-87	154	10	based	base	VERB
hjic-87	154	11	techniques	technique	NOUN
hjic-87	154	12	is	be	AUX
hjic-87	154	13	the	the	DET
hjic-87	154	14	fact	fact	NOUN
hjic-87	154	15	that	that	SCONJ
hjic-87	154	16	scf	scf	PROPN
hjic-87	154	17	plays	play	VERB
hjic-87	154	18	both	both	CCONJ
hjic-87	154	19	the	the	DET
hjic-87	154	20	role	role	NOUN
hjic-87	154	21	of	of	ADP
hjic-87	154	22	dispersing	disperse	VERB
hjic-87	154	23	fluid	fluid	NOUN
hjic-87	154	24	and	and	CCONJ
hjic-87	154	25	antisolvent	antisolvent	NOUN
hjic-87	154	26	which	which	PRON
hjic-87	154	27	allows	allow	VERB
hjic-87	154	28	better	well	ADJ
hjic-87	154	29	control	control	NOUN
hjic-87	154	30	over	over	ADP
hjic-87	154	31	mean	mean	ADJ
hjic-87	154	32	size	size	NOUN
hjic-87	154	33	and	and	CCONJ
hjic-87	154	34	size	size	NOUN
hjic-87	154	35	-	-	PUNCT
hjic-87	154	36	distribution	distribution	NOUN
hjic-87	154	37	of	of	ADP
hjic-87	154	38	the	the	DET
hjic-87	154	39	product	product	NOUN
hjic-87	154	40	.	.	PUNCT
hjic-87	155	1	47	47	NUM
hjic-87	155	2	table	table	NOUN
hjic-87	155	3	4	4	NUM
hjic-87	155	4	summary	summary	NOUN
hjic-87	155	5	of	of	ADP
hjic-87	155	6	drug	drug	NOUN
hjic-87	155	7	-	-	PUNCT
hjic-87	155	8	carrier	carrier	NOUN
hjic-87	155	9	systems	system	NOUN
hjic-87	155	10	precipitated	precipitate	VERB
hjic-87	155	11	by	by	ADP
hjic-87	155	12	sas	sas	PROPN
hjic-87	155	13	,	,	PUNCT
hjic-87	155	14	ases	as	NOUN
hjic-87	155	15	,	,	PUNCT
hjic-87	155	16	pca	pca	NOUN
hjic-87	155	17	and	and	CCONJ
hjic-87	155	18	related	related	ADJ
hjic-87	155	19	methods	method	NOUN
hjic-87	155	20	.	.	PUNCT
hjic-87	156	1	substrate	substrate	NOUN
hjic-87	156	2	excipient	excipient	ADJ
hjic-87	156	3	observation	observation	NOUN
hjic-87	156	4	references	reference	NOUN
hjic-87	156	5	clonidin	clonidin	VERB
hjic-87	156	6	-	-	ADJ
hjic-87	156	7	hcl	hcl	ADJ
hjic-87	156	8	pla	pla	NOUN
hjic-87	156	9	agglomerated	agglomerate	VERB
hjic-87	156	10	spheres	sphere	NOUN
hjic-87	156	11	,	,	PUNCT
hjic-87	156	12	10	10	NUM
hjic-87	156	13	–	–	SYM
hjic-87	156	14	100	100	NUM
hjic-87	156	15	µm	µm	ADP
hjic-87	156	16	[	[	X
hjic-87	156	17	40	40	NUM
hjic-87	156	18	]	]	PUNCT
hjic-87	156	19	hyoscine	hyoscine	ADJ
hjic-87	156	20	butyl	butyl	NOUN
hjic-87	156	21	-	-	PUNCT
hjic-87	156	22	bromide	bromide	NOUN
hjic-87	156	23	pla	pla	NOUN
hjic-87	156	24	agglomerated	agglomerate	VERB
hjic-87	156	25	particles	particle	NOUN
hjic-87	156	26	,	,	PUNCT
hjic-87	156	27	<	<	X
hjic-87	156	28	20	20	NUM
hjic-87	156	29	µm	µm	NOUN
hjic-87	156	30	[	[	X
hjic-87	156	31	48	48	NUM
hjic-87	156	32	]	]	PUNCT
hjic-87	156	33	hyoscine	hyoscine	ADJ
hjic-87	156	34	butylbromide	butylbromide	ADJ
hjic-87	156	35	,	,	PUNCT
hjic-87	156	36	indomethacin	indomethacin	NOUN
hjic-87	156	37	,	,	PUNCT
hjic-87	156	38	piroxicam	piroxicam	ADJ
hjic-87	156	39	,	,	PUNCT
hjic-87	156	40	thymopentin	thymopentin	NOUN
hjic-87	156	41	pla	pla	NOUN
hjic-87	156	42	microcapsules	microcapsule	NOUN
hjic-87	156	43	[	[	X
hjic-87	156	44	49	49	NUM
hjic-87	156	45	]	]	PUNCT
hjic-87	156	46	thymopentine	thymopentine	NOUN
hjic-87	156	47	plga	plga	VERB
hjic-87	156	48	lecithin	lecithin	NOUN
hjic-87	156	49	microcapsules	microcapsule	NOUN
hjic-87	157	1	[	[	X
hjic-87	157	2	50	50	NUM
hjic-87	157	3	]	]	PUNCT
hjic-87	157	4	naproxen	naproxen	NOUN
hjic-87	157	5	pla	pla	PROPN
hjic-87	157	6	mean	mean	VERB
hjic-87	157	7	particle	particle	NOUN
hjic-87	157	8	size	size	NOUN
hjic-87	157	9	:	:	PUNCT
hjic-87	157	10	5	5	NUM
hjic-87	157	11	µm	µm	ADP
hjic-87	157	12	[	[	X
hjic-87	157	13	51	51	NUM
hjic-87	157	14	]	]	X
hjic-87	157	15	steroidsa	steroidsa	NOUN
hjic-87	157	16	pcb	pcb	PROPN
hjic-87	157	17	mean	mean	VERB
hjic-87	157	18	particle	particle	NOUN
hjic-87	157	19	size	size	NOUN
hjic-87	157	20	:	:	PUNCT
hjic-87	157	21	2	2	NUM
hjic-87	157	22	9	9	NUM
hjic-87	157	23	µm	µm	ADP
hjic-87	157	24	[	[	NOUN
hjic-87	157	25	52	52	NUM
hjic-87	157	26	]	]	PUNCT
hjic-87	157	27	gentamycin	gentamycin	PROPN
hjic-87	157	28	,	,	PUNCT
hjic-87	157	29	naltrexone	naltrexone	NOUN
hjic-87	157	30	,	,	PUNCT
hjic-87	157	31	rifampin	rifampin	VERB
hjic-87	157	32	aotc	aotc	PROPN
hjic-87	157	33	pla	pla	PROPN
hjic-87	157	34	spherical	spherical	ADJ
hjic-87	157	35	particles	particle	NOUN
hjic-87	157	36	,	,	PUNCT
hjic-87	157	37	0,2	0,2	NUM
hjic-87	157	38	1	1	NUM
hjic-87	157	39	µm	µm	ADP
hjic-87	157	40	[	[	X
hjic-87	157	41	42,43	42,43	NOUN
hjic-87	157	42	]	]	PUNCT
hjic-87	157	43	tetracosactide	tetracosactide	NOUN
hjic-87	157	44	pla	pla	NOUN
hjic-87	157	45	microcapsules	microcapsule	NOUN
hjic-87	157	46	,	,	PUNCT
hjic-87	157	47	5,9	5,9	NUM
hjic-87	157	48	µm	µm	ADP
hjic-87	157	49	[	[	X
hjic-87	157	50	53,54	53,54	X
hjic-87	157	51	]	]	X
hjic-87	157	52	pla	pla	NOUN
hjic-87	157	53	fibrous	fibrous	ADJ
hjic-87	157	54	network	network	NOUN
hjic-87	157	55	p	p	NOUN
hjic-87	157	56	-	-	PUNCT
hjic-87	157	57	hba	hba	NOUN
hjic-87	157	58	plga	plga	NOUN
hjic-87	157	59	microcapsules	microcapsule	NOUN
hjic-87	158	1	[	[	X
hjic-87	158	2	46	46	NUM
hjic-87	158	3	]	]	X
hjic-87	158	4	α	α	X
hjic-87	158	5	-	-	NOUN
hjic-87	158	6	chymotrypsin	chymotrypsin	ADJ
hjic-87	158	7	aot	aot	PROPN
hjic-87	158	8	pla	pla	PROPN
hjic-87	158	9	spherical	spherical	ADJ
hjic-87	158	10	particles	particle	NOUN
hjic-87	158	11	,	,	PUNCT
hjic-87	158	12	2	2	NUM
hjic-87	158	13	3	3	NUM
hjic-87	158	14	µm	µm	ADP
hjic-87	158	15	insulin	insulin	NOUN
hjic-87	158	16	sds	sds	NOUN
hjic-87	158	17	spherical	spherical	ADJ
hjic-87	158	18	and	and	CCONJ
hjic-87	158	19	irregular	irregular	ADJ
hjic-87	158	20	particles	particle	NOUN
hjic-87	158	21	1	1	NUM
hjic-87	158	22	5	5	NUM
hjic-87	158	23	µm	µm	NOUN
hjic-87	158	24	ribonuclease	ribonuclease	NOUN
hjic-87	158	25	peg	peg	NOUN
hjic-87	158	26	sds	sds	PROPN
hjic-87	158	27	fiber	fiber	NOUN
hjic-87	158	28	-	-	PUNCT
hjic-87	158	29	like	like	ADJ
hjic-87	158	30	and	and	CCONJ
hjic-87	158	31	spherical	spherical	ADJ
hjic-87	158	32	particles	particle	NOUN
hjic-87	158	33	0,5	0,5	NUM
hjic-87	158	34	1	1	NUM
hjic-87	158	35	µm	µm	ADP
hjic-87	158	36	cytochrome	cytochrome	PROPN
hjic-87	158	37	c	c	PROPN
hjic-87	158	38	sds	sds	PROPN
hjic-87	158	39	collapsed	collapse	VERB
hjic-87	158	40	spherical	spherical	ADJ
hjic-87	158	41	particles	particle	NOUN
hjic-87	158	42	,	,	PUNCT
hjic-87	158	43	5	5	NUM
hjic-87	158	44	µm	µm	NUM
hjic-87	158	45	pentamidine	pentamidine	VERB
hjic-87	158	46	sds	sds	PROPN
hjic-87	158	47	spherical	spherical	ADJ
hjic-87	158	48	particles	particle	NOUN
hjic-87	158	49	,	,	PUNCT
hjic-87	158	50	0,1	0,1	NUM
hjic-87	158	51	–	–	PUNCT
hjic-87	158	52	1	1	NUM
hjic-87	158	53	µm	µm	ADP
hjic-87	158	54	streptomicin	streptomicin	VERB
hjic-87	158	55	aot	aot	VERB
hjic-87	158	56	spherical	spherical	ADJ
hjic-87	158	57	particles	particle	NOUN
hjic-87	158	58	,	,	PUNCT
hjic-87	158	59	0,4	0,4	NUM
hjic-87	158	60	–	–	PUNCT
hjic-87	158	61	1	1	NUM
hjic-87	158	62	µm	µm	ADP
hjic-87	158	63	[	[	NOUN
hjic-87	158	64	42	42	NUM
hjic-87	158	65	]	]	X
hjic-87	158	66	albumin	albumin	PROPN
hjic-87	158	67	estriol	estriol	PROPN
hjic-87	158	68	plga	plga	PROPN
hjic-87	158	69	agglomerated	agglomerate	VERB
hjic-87	158	70	spherical	spherical	ADJ
hjic-87	158	71	particles	particle	NOUN
hjic-87	158	72	,	,	PUNCT
hjic-87	158	73	10	10	NUM
hjic-87	158	74	–	–	PUNCT
hjic-87	158	75	130	130	NUM
hjic-87	158	76	µm	µm	ADP
hjic-87	158	77	[	[	NOUN
hjic-87	158	78	55	55	NUM
hjic-87	158	79	]	]	PUNCT
hjic-87	158	80	chimotrypsin	chimotrypsin	PROPN
hjic-87	158	81	-	-	PUNCT
hjic-87	158	82	aot	aot	NOUN
hjic-87	158	83	insulin	insulin	NOUN
hjic-87	158	84	-	-	PUNCT
hjic-87	158	85	lauric	lauric	ADJ
hjic-87	158	86	acid	acid	NOUN
hjic-87	158	87	conjugate	conjugate	ADJ
hjic-87	158	88	insulin	insulin	NOUN
hjic-87	158	89	lysozyme	lysozyme	NOUN
hjic-87	158	90	pla	pla	NOUN
hjic-87	158	91	mean	mean	VERB
hjic-87	158	92	particle	particle	NOUN
hjic-87	158	93	size	size	NOUN
hjic-87	158	94	:	:	PUNCT
hjic-87	158	95	1	1	NUM
hjic-87	158	96	–	–	SYM
hjic-87	158	97	5	5	NUM
hjic-87	158	98	µm	µm	ADP
hjic-87	158	99	[	[	NOUN
hjic-87	158	100	56	56	NUM
hjic-87	158	101	]	]	X
hjic-87	158	102	diuron	diuron	NOUN
hjic-87	158	103	d	d	PROPN
hjic-87	158	104	pla	pla	NOUN
hjic-87	158	105	microcapsules	microcapsule	NOUN
hjic-87	158	106	,	,	PUNCT
hjic-87	158	107	1	1	NUM
hjic-87	158	108	5	5	NUM
hjic-87	158	109	µm	µm	ADP
hjic-87	158	110	[	[	NOUN
hjic-87	158	111	45	45	NUM
hjic-87	158	112	]	]	PUNCT
hjic-87	158	113	insulin	insulin	NOUN
hjic-87	158	114	peg	peg	NOUN
hjic-87	158	115	pla	pla	PROPN
hjic-87	158	116	drug	drug	NOUN
hjic-87	158	117	-	-	PUNCT
hjic-87	158	118	loaded	load	VERB
hjic-87	158	119	spheres	sphere	NOUN
hjic-87	158	120	,	,	PUNCT
hjic-87	158	121	0,4	0,4	NUM
hjic-87	158	122	–	–	PUNCT
hjic-87	158	123	0,6	0,6	NUM
hjic-87	158	124	µm	µm	ADP
hjic-87	158	125	[	[	NOUN
hjic-87	158	126	57	57	NUM
hjic-87	158	127	]	]	PUNCT
hjic-87	158	128	insulin	insulin	NOUN
hjic-87	158	129	pla	pla	NOUN
hjic-87	158	130	drug	drug	NOUN
hjic-87	158	131	-	-	PUNCT
hjic-87	158	132	loaded	load	VERB
hjic-87	158	133	spheres	sphere	NOUN
hjic-87	158	134	,	,	PUNCT
hjic-87	158	135	0,5	0,5	NUM
hjic-87	158	136	–	–	PUNCT
hjic-87	158	137	2	2	NUM
hjic-87	158	138	µm	µm	ADP
hjic-87	158	139	[	[	NOUN
hjic-87	158	140	58	58	NUM
hjic-87	158	141	]	]	X
hjic-87	158	142	p	p	X
hjic-87	158	143	-	-	PUNCT
hjic-87	158	144	hba	hba	NOUN
hjic-87	158	145	lysosyme	lysosyme	NOUN
hjic-87	158	146	pla	pla	PROPN
hjic-87	158	147	agglomerated	agglomerate	VERB
hjic-87	158	148	irregular	irregular	ADJ
hjic-87	158	149	particles	particle	NOUN
hjic-87	158	150	[	[	X
hjic-87	158	151	47	47	NUM
hjic-87	158	152	]	]	PUNCT
hjic-87	158	153	budesonide	budesonide	PROPN
hjic-87	158	154	pla	pla	PROPN
hjic-87	158	155	spherical	spherical	ADJ
hjic-87	158	156	particles	particle	NOUN
hjic-87	158	157	,	,	PUNCT
hjic-87	158	158	1	1	NUM
hjic-87	158	159	–	–	SYM
hjic-87	158	160	2	2	NUM
hjic-87	158	161	µm	µm	ADP
hjic-87	158	162	[	[	NOUN
hjic-87	158	163	59	59	NUM
hjic-87	158	164	]	]	X
hjic-87	158	165	rhdnase	rhdnase	NOUN
hjic-87	158	166	e	e	NOUN
hjic-87	158	167	lysosyme	lysosyme	NOUN
hjic-87	158	168	lactose	lactose	ADJ
hjic-87	158	169	amorphous	amorphous	ADJ
hjic-87	158	170	agglomerated	agglomerate	VERB
hjic-87	158	171	spheres	sphere	NOUN
hjic-87	158	172	[	[	X
hjic-87	158	173	60	60	NUM
hjic-87	158	174	]	]	X
hjic-87	158	175	copper	copper	NOUN
hjic-87	158	176	indomethacin	indomethacin	VERB
hjic-87	158	177	pvp	pvp	VERB
hjic-87	158	178	solid	solid	ADJ
hjic-87	158	179	dispersion	dispersion	NOUN
hjic-87	158	180	,	,	PUNCT
hjic-87	158	181	0,05	0,05	PROPN
hjic-87	158	182	–	–	PUNCT
hjic-87	158	183	4	4	NUM
hjic-87	158	184	µm	µm	NOUN
hjic-87	158	185	[	[	NOUN
hjic-87	158	186	61	61	NUM
hjic-87	158	187	]	]	PUNCT
hjic-87	158	188	insulin	insulin	NOUN
hjic-87	158	189	peg	peg	NOUN
hjic-87	158	190	pla	pla	NOUN
hjic-87	158	191	agglomerated	agglomerate	VERB
hjic-87	158	192	spherical	spherical	ADJ
hjic-87	158	193	particles	particle	NOUN
hjic-87	158	194	,	,	PUNCT
hjic-87	158	195	360	360	NUM
hjic-87	158	196	–	–	SYM
hjic-87	158	197	720	720	NUM
hjic-87	158	198	nm	nm	NOUN
hjic-87	158	199	[	[	X
hjic-87	158	200	62	62	NUM
hjic-87	158	201	]	]	PUNCT
hjic-87	158	202	a	a	DET
hjic-87	158	203	beclomethasone-17,21	beclomethasone-17,21	NOUN
hjic-87	158	204	-	-	PUNCT
hjic-87	158	205	dipropionate	dipropionate	NOUN
hjic-87	158	206	,	,	PUNCT
hjic-87	158	207	betamethasone-17	betamethasone-17	NOUN
hjic-87	158	208	-	-	PUNCT
hjic-87	158	209	valerate	valerate	NOUN
hjic-87	158	210	,	,	PUNCT
hjic-87	158	211	budesonide	budesonide	NOUN
hjic-87	158	212	,	,	PUNCT
hjic-87	158	213	dexamethasone-21	dexamethasone-21	PROPN
hjic-87	158	214	-	-	PUNCT
hjic-87	158	215	acetate	acetate	NOUN
hjic-87	158	216	,	,	PUNCT
hjic-87	158	217	flunisolide	flunisolide	NOUN
hjic-87	158	218	,	,	PUNCT
hjic-87	158	219	fluticasone-17	fluticasone-17	NOUN
hjic-87	158	220	-	-	NOUN
hjic-87	158	221	propionate	propionate	NOUN
hjic-87	158	222	,	,	PUNCT
hjic-87	158	223	prednisolone	prednisolone	PROPN
hjic-87	158	224	and	and	CCONJ
hjic-87	158	225	triamcinolone	triamcinolone	NOUN
hjic-87	158	226	acetonide	acetonide	VERB
hjic-87	158	227	;	;	PUNCT
hjic-87	158	228	b	b	X
hjic-87	158	229	phosphatidylcholine	phosphatidylcholine	NOUN
hjic-87	158	230	;	;	PUNCT
hjic-87	158	231	c	c	PROPN
hjic-87	158	232	bis-(2	bis-(2	PROPN
hjic-87	158	233	-	-	PUNCT
hjic-87	158	234	ethylhexyl	ethylhexyl	PROPN
hjic-87	158	235	)	)	PUNCT
hjic-87	158	236	sodium	sodium	NOUN
hjic-87	158	237	sulfosuccinate	sulfosuccinate	NOUN
hjic-87	158	238	;	;	PUNCT
hjic-87	158	239	d	d	X
hjic-87	158	240	herbicide	herbicide	NOUN
hjic-87	158	241	;	;	PUNCT
hjic-87	158	242	e	e	X
hjic-87	158	243	recombinant	recombinant	ADJ
hjic-87	158	244	human	human	ADJ
hjic-87	158	245	deoxyribonuclease	deoxyribonuclease	NOUN
hjic-87	158	246	;	;	PUNCT
hjic-87	158	247	in	in	ADP
hjic-87	158	248	their	their	PRON
hjic-87	158	249	first	first	ADJ
hjic-87	158	250	seds	sed	NOUN
hjic-87	158	251	patent	patent	PROPN
hjic-87	158	252	york	york	PROPN
hjic-87	158	253	et	et	PROPN
hjic-87	158	254	al	al	PROPN
hjic-87	158	255	.	.	PROPN
hjic-87	158	256	reported	report	VERB
hjic-87	158	257	the	the	DET
hjic-87	158	258	coprecipitation	coprecipitation	NOUN
hjic-87	158	259	of	of	ADP
hjic-87	158	260	salmeterol	salmeterol	NOUN
hjic-87	158	261	xinafoate	xinafoate	VERB
hjic-87	158	262	with	with	ADP
hjic-87	158	263	hydroxypropylcellulose	hydroxypropylcellulose	NOUN
hjic-87	158	264	from	from	ADP
hjic-87	158	265	acetone	acetone	NOUN
hjic-87	158	266	using	use	VERB
hjic-87	158	267	both	both	CCONJ
hjic-87	158	268	twoand	twoand	CCONJ
hjic-87	158	269	three	three	NUM
hjic-87	158	270	-	-	PUNCT
hjic-87	158	271	passage	passage	NOUN
hjic-87	158	272	nozzles	nozzle	NOUN
hjic-87	158	273	[	[	X
hjic-87	158	274	63	63	NUM
hjic-87	158	275	]	]	PUNCT
hjic-87	158	276	.	.	PUNCT
hjic-87	159	1	in	in	ADP
hjic-87	159	2	both	both	DET
hjic-87	159	3	cases	case	NOUN
hjic-87	159	4	peaks	peak	NOUN
hjic-87	159	5	of	of	ADP
hjic-87	159	6	salmeterol	salmeterol	NOUN
hjic-87	159	7	xinafoate	xinafoate	ADJ
hjic-87	159	8	were	be	AUX
hjic-87	159	9	weaker	weak	ADJ
hjic-87	159	10	in	in	ADP
hjic-87	159	11	xray	xray	ADJ
hjic-87	159	12	diffraction	diffraction	NOUN
hjic-87	159	13	patterns	pattern	NOUN
hjic-87	159	14	due	due	ADP
hjic-87	159	15	to	to	ADP
hjic-87	159	16	the	the	DET
hjic-87	159	17	amorphous	amorphous	ADJ
hjic-87	159	18	fraction	fraction	NOUN
hjic-87	159	19	of	of	ADP
hjic-87	159	20	the	the	DET
hjic-87	159	21	incorporated	incorporate	VERB
hjic-87	159	22	drug	drug	NOUN
hjic-87	159	23	.	.	PUNCT
hjic-87	160	1	since	since	SCONJ
hjic-87	160	2	water	water	NOUN
hjic-87	160	3	is	be	AUX
hjic-87	160	4	hardly	hardly	ADV
hjic-87	160	5	miscible	miscible	ADJ
hjic-87	160	6	with	with	ADP
hjic-87	160	7	scco2	scco2	NOUN
hjic-87	160	8	,	,	PUNCT
hjic-87	160	9	hydrophilic	hydrophilic	ADJ
hjic-87	160	10	compounds	compound	NOUN
hjic-87	160	11	like	like	ADP
hjic-87	160	12	sugars	sugar	NOUN
hjic-87	160	13	can	can	AUX
hjic-87	160	14	not	not	PART
hjic-87	160	15	be	be	AUX
hjic-87	160	16	processed	process	VERB
hjic-87	160	17	directly	directly	ADV
hjic-87	160	18	.	.	PUNCT
hjic-87	161	1	for	for	ADP
hjic-87	161	2	this	this	DET
hjic-87	161	3	reason	reason	NOUN
hjic-87	161	4	york	york	PROPN
hjic-87	161	5	et	et	PROPN
hjic-87	161	6	al	al	PROPN
hjic-87	161	7	.	.	PROPN
hjic-87	161	8	have	have	AUX
hjic-87	161	9	completed	complete	VERB
hjic-87	161	10	their	their	PRON
hjic-87	161	11	previous	previous	ADJ
hjic-87	161	12	patent	patent	NOUN
hjic-87	161	13	by	by	ADP
hjic-87	161	14	describing	describe	VERB
hjic-87	161	15	a	a	DET
hjic-87	161	16	48	48	NUM
hjic-87	161	17	process	process	NOUN
hjic-87	161	18	in	in	ADP
hjic-87	161	19	which	which	PRON
hjic-87	161	20	sugars	sugar	NOUN
hjic-87	161	21	are	be	AUX
hjic-87	161	22	precipitated	precipitate	VERB
hjic-87	161	23	from	from	ADP
hjic-87	161	24	aqueous	aqueous	ADJ
hjic-87	161	25	solution	solution	NOUN
hjic-87	161	26	by	by	ADP
hjic-87	161	27	mixing	mix	VERB
hjic-87	161	28	it	it	PRON
hjic-87	161	29	with	with	ADP
hjic-87	161	30	a	a	DET
hjic-87	161	31	cosolvent	cosolvent	ADJ
hjic-87	161	32	(	(	PUNCT
hjic-87	161	33	ethanol	ethanol	NOUN
hjic-87	161	34	or	or	CCONJ
hjic-87	161	35	methanol	methanol	NOUN
hjic-87	161	36	)	)	PUNCT
hjic-87	161	37	which	which	PRON
hjic-87	161	38	make	make	VERB
hjic-87	161	39	water	water	NOUN
hjic-87	161	40	miscible	miscible	ADJ
hjic-87	161	41	with	with	ADP
hjic-87	161	42	scco2	scco2	NOUN
hjic-87	161	43	in	in	ADP
hjic-87	161	44	a	a	DET
hjic-87	161	45	restricted	restricted	ADJ
hjic-87	161	46	concentration	concentration	NOUN
hjic-87	161	47	range	range	NOUN
hjic-87	161	48	[	[	X
hjic-87	161	49	64	64	NUM
hjic-87	161	50	]	]	PUNCT
hjic-87	161	51	.	.	PUNCT
hjic-87	162	1	as	as	SCONJ
hjic-87	162	2	amorphous	amorphous	ADJ
hjic-87	162	3	phase	phase	NOUN
hjic-87	162	4	drugs	drug	NOUN
hjic-87	162	5	are	be	AUX
hjic-87	162	6	generally	generally	ADV
hjic-87	162	7	considered	consider	VERB
hjic-87	162	8	to	to	PART
hjic-87	162	9	be	be	AUX
hjic-87	162	10	meta	meta	ADJ
hjic-87	162	11	-	-	ADJ
hjic-87	162	12	stable	stable	ADJ
hjic-87	162	13	,	,	PUNCT
hjic-87	162	14	their	their	PRON
hjic-87	162	15	stability	stability	NOUN
hjic-87	162	16	over	over	ADP
hjic-87	162	17	the	the	DET
hjic-87	162	18	storage	storage	NOUN
hjic-87	162	19	period	period	NOUN
hjic-87	162	20	at	at	ADP
hjic-87	162	21	ambient	ambient	ADJ
hjic-87	162	22	temperature	temperature	NOUN
hjic-87	162	23	is	be	AUX
hjic-87	162	24	a	a	DET
hjic-87	162	25	crucial	crucial	ADJ
hjic-87	162	26	point	point	NOUN
hjic-87	162	27	.	.	PUNCT
hjic-87	163	1	to	to	PART
hjic-87	163	2	demonstrate	demonstrate	VERB
hjic-87	163	3	the	the	DET
hjic-87	163	4	viability	viability	NOUN
hjic-87	163	5	of	of	ADP
hjic-87	163	6	seds	sed	NOUN
hjic-87	163	7	york	york	PROPN
hjic-87	163	8	et	et	PROPN
hjic-87	163	9	al	al	PROPN
hjic-87	163	10	.	.	PROPN
hjic-87	163	11	has	have	AUX
hjic-87	163	12	devoted	devote	VERB
hjic-87	163	13	a	a	DET
hjic-87	163	14	whole	whole	ADJ
hjic-87	163	15	patent	patent	NOUN
hjic-87	163	16	to	to	ADP
hjic-87	163	17	coprecipitating	coprecipitate	VERB
hjic-87	163	18	drug	drug	NOUN
hjic-87	163	19	-	-	PUNCT
hjic-87	163	20	carrier	carrier	NOUN
hjic-87	163	21	systems	system	NOUN
hjic-87	163	22	[	[	X
hjic-87	163	23	67	67	NUM
hjic-87	163	24	]	]	PUNCT
hjic-87	163	25	.	.	PUNCT
hjic-87	164	1	the	the	DET
hjic-87	164	2	drugs	drug	NOUN
hjic-87	164	3	were	be	AUX
hjic-87	164	4	chosen	choose	VERB
hjic-87	164	5	to	to	PART
hjic-87	164	6	cover	cover	VERB
hjic-87	164	7	a	a	DET
hjic-87	164	8	broad	broad	ADJ
hjic-87	164	9	range	range	NOUN
hjic-87	164	10	of	of	ADP
hjic-87	164	11	polarities	polarity	NOUN
hjic-87	164	12	including	include	VERB
hjic-87	164	13	the	the	DET
hjic-87	164	14	highly	highly	ADV
hjic-87	164	15	apolar	apolar	ADJ
hjic-87	164	16	ketoprofen	ketoprofen	NOUN
hjic-87	164	17	and	and	CCONJ
hjic-87	164	18	in	in	ADP
hjic-87	164	19	ascending	ascend	VERB
hjic-87	164	20	order	order	NOUN
hjic-87	164	21	of	of	ADP
hjic-87	164	22	polarity	polarity	NOUN
hjic-87	164	23	,	,	PUNCT
hjic-87	164	24	indomethacin	indomethacin	NOUN
hjic-87	164	25	,	,	PUNCT
hjic-87	164	26	carbamazepine	carbamazepine	NOUN
hjic-87	164	27	,	,	PUNCT
hjic-87	164	28	paracetamol	paracetamol	NOUN
hjic-87	164	29	,	,	PUNCT
hjic-87	164	30	theophylline	theophylline	NOUN
hjic-87	164	31	and	and	CCONJ
hjic-87	164	32	ascorbic	ascorbic	NOUN
hjic-87	164	33	acid	acid	NOUN
hjic-87	164	34	.	.	PUNCT
hjic-87	165	1	the	the	DET
hjic-87	165	2	coformulation	coformulation	NOUN
hjic-87	165	3	of	of	ADP
hjic-87	165	4	these	these	DET
hjic-87	165	5	drugs	drug	NOUN
hjic-87	165	6	with	with	ADP
hjic-87	165	7	hydrophilic	hydrophilic	ADJ
hjic-87	165	8	hydroxypropylmethylcellulose	hydroxypropylmethylcellulose	VERB
hjic-87	165	9	(	(	PUNCT
hjic-87	165	10	hpmc	hpmc	ADJ
hjic-87	165	11	)	)	PUNCT
hjic-87	165	12	,	,	PUNCT
hjic-87	165	13	pvp	pvp	NOUN
hjic-87	165	14	and	and	CCONJ
hjic-87	165	15	hydrophobic	hydrophobic	NOUN
hjic-87	165	16	ec	ec	PROPN
hjic-87	165	17	polymers	polymer	NOUN
hjic-87	165	18	revealed	reveal	VERB
hjic-87	165	19	that	that	SCONJ
hjic-87	165	20	the	the	PRON
hjic-87	165	21	more	more	ADV
hjic-87	165	22	they	they	PRON
hjic-87	165	23	are	be	AUX
hjic-87	165	24	alike	alike	ADV
hjic-87	165	25	in	in	ADP
hjic-87	165	26	polar	polar	ADJ
hjic-87	165	27	and	and	CCONJ
hjic-87	165	28	hydrogen	hydrogen	NOUN
hjic-87	165	29	bonding	bonding	NOUN
hjic-87	165	30	characteristics	characteristic	NOUN
hjic-87	165	31	the	the	DET
hjic-87	165	32	higher	high	ADJ
hjic-87	165	33	concentration	concentration	NOUN
hjic-87	165	34	of	of	ADP
hjic-87	165	35	amorphous	amorphous	ADJ
hjic-87	165	36	phase	phase	NOUN
hjic-87	165	37	can	can	AUX
hjic-87	165	38	be	be	AUX
hjic-87	165	39	achieved	achieve	VERB
hjic-87	165	40	.	.	PUNCT
hjic-87	166	1	the	the	DET
hjic-87	166	2	amorphous	amorphous	ADJ
hjic-87	166	3	phase	phase	NOUN
hjic-87	166	4	of	of	ADP
hjic-87	166	5	indomethacin	indomethacin	NOUN
hjic-87	166	6	coformulated	coformulate	VERB
hjic-87	166	7	with	with	ADP
hjic-87	166	8	all	all	DET
hjic-87	166	9	three	three	NUM
hjic-87	166	10	excipient	excipient	NOUN
hjic-87	166	11	was	be	AUX
hjic-87	166	12	the	the	DET
hjic-87	166	13	most	most	ADV
hjic-87	166	14	dominant	dominant	ADJ
hjic-87	166	15	in	in	ADP
hjic-87	166	16	pvp	pvp	NOUN
hjic-87	166	17	(	(	PUNCT
hjic-87	166	18	60	60	NUM
hjic-87	166	19	%	%	NOUN
hjic-87	166	20	)	)	PUNCT
hjic-87	166	21	followed	follow	VERB
hjic-87	166	22	by	by	ADP
hjic-87	166	23	hpmc	hpmc	PROPN
hjic-87	166	24	(	(	PUNCT
hjic-87	166	25	35	35	NUM
hjic-87	166	26	%	%	NOUN
hjic-87	166	27	)	)	PUNCT
hjic-87	166	28	and	and	CCONJ
hjic-87	166	29	ec	ec	PROPN
hjic-87	166	30	(	(	PUNCT
hjic-87	166	31	25	25	NUM
hjic-87	166	32	%	%	NOUN
hjic-87	166	33	)	)	PUNCT
hjic-87	166	34	.	.	PUNCT
hjic-87	167	1	furthermore	furthermore	ADV
hjic-87	167	2	,	,	PUNCT
hjic-87	167	3	york	york	PROPN
hjic-87	167	4	et	et	PROPN
hjic-87	167	5	al	al	PROPN
hjic-87	167	6	.	.	PROPN
hjic-87	167	7	have	have	AUX
hjic-87	167	8	coprecipitated	coprecipitate	VERB
hjic-87	167	9	two	two	NUM
hjic-87	167	10	cyclo	cyclo	NOUN
hjic-87	167	11	-	-	PUNCT
hjic-87	167	12	oxygenase-2	oxygenase-2	NUM
hjic-87	167	13	(	(	PUNCT
hjic-87	167	14	cox-2	cox-2	NOUN
hjic-87	167	15	)	)	PUNCT
hjic-87	167	16	inhibitors	inhibitor	NOUN
hjic-87	167	17	with	with	ADP
hjic-87	167	18	hydroxypropylcellulose	hydroxypropylcellulose	NOUN
hjic-87	167	19	(	(	PUNCT
hjic-87	167	20	hpc	hpc	NOUN
hjic-87	167	21	)	)	PUNCT
hjic-87	167	22	and	and	CCONJ
hjic-87	167	23	poloxamer	poloxamer	NOUN
hjic-87	167	24	237	237	NUM
hjic-87	167	25	as	as	ADV
hjic-87	167	26	well	well	ADV
hjic-87	167	27	as	as	ADP
hjic-87	167	28	an	an	DET
hjic-87	167	29	anti	anti	ADJ
hjic-87	167	30	-	-	ADJ
hjic-87	167	31	diabetic	diabetic	ADJ
hjic-87	167	32	drug	drug	NOUN
hjic-87	167	33	with	with	ADP
hjic-87	167	34	75/25	75/25	NUM
hjic-87	167	35	dl	dl	NOUN
hjic-87	167	36	-	-	PUNCT
hjic-87	167	37	lactide	lactide	NOUN
hjic-87	167	38	-	-	PUNCT
hjic-87	167	39	co	co	NOUN
hjic-87	167	40	-	-	NOUN
hjic-87	167	41	caprolactone	caprolactone	NOUN
hjic-87	167	42	.	.	PUNCT
hjic-87	168	1	the	the	DET
hjic-87	168	2	reduction	reduction	NOUN
hjic-87	168	3	of	of	ADP
hjic-87	168	4	crystallinity	crystallinity	NOUN
hjic-87	168	5	level	level	NOUN
hjic-87	168	6	was	be	AUX
hjic-87	168	7	linear	linear	ADJ
hjic-87	168	8	in	in	ADP
hjic-87	168	9	the	the	DET
hjic-87	168	10	whole	whole	ADJ
hjic-87	168	11	concentration	concentration	NOUN
hjic-87	168	12	range	range	NOUN
hjic-87	168	13	for	for	ADP
hjic-87	168	14	poloxamer	poloxamer	PROPN
hjic-87	168	15	237	237	NUM
hjic-87	168	16	and	and	CCONJ
hjic-87	168	17	above	above	ADP
hjic-87	168	18	20	20	NUM
hjic-87	168	19	%	%	NOUN
hjic-87	168	20	for	for	ADP
hjic-87	168	21	hpc	hpc	PROPN
hjic-87	168	22	.	.	PUNCT
hjic-87	169	1	all	all	DET
hjic-87	169	2	these	these	DET
hjic-87	169	3	drug	drug	NOUN
hjic-87	169	4	-	-	PUNCT
hjic-87	169	5	carrier	carrier	NOUN
hjic-87	169	6	systems	system	NOUN
hjic-87	169	7	proved	prove	VERB
hjic-87	169	8	to	to	PART
hjic-87	169	9	be	be	AUX
hjic-87	169	10	stable	stable	ADJ
hjic-87	169	11	for	for	ADP
hjic-87	169	12	at	at	ADV
hjic-87	169	13	least	least	ADV
hjic-87	169	14	three	three	NUM
hjic-87	169	15	months	month	NOUN
hjic-87	169	16	stored	store	VERB
hjic-87	169	17	between	between	ADP
hjic-87	169	18	0	0	NUM
hjic-87	169	19	and	and	CCONJ
hjic-87	169	20	25	25	NUM
hjic-87	169	21	°	°	NOUN
hjic-87	169	22	c	c	NOUN
hjic-87	169	23	.	.	PUNCT
hjic-87	170	1	juppo	juppo	PROPN
hjic-87	170	2	et	et	PROPN
hjic-87	170	3	al	al	PROPN
hjic-87	170	4	.	.	PROPN
hjic-87	170	5	studied	study	VERB
hjic-87	170	6	the	the	DET
hjic-87	170	7	formation	formation	NOUN
hjic-87	170	8	of	of	ADP
hjic-87	170	9	solid	solid	ADJ
hjic-87	170	10	dispersion	dispersion	NOUN
hjic-87	170	11	of	of	ADP
hjic-87	170	12	the	the	DET
hjic-87	170	13	model	model	NOUN
hjic-87	170	14	drug	drug	NOUN
hjic-87	170	15	2,6	2,6	NUM
hjic-87	170	16	-	-	ADJ
hjic-87	170	17	dimethyl-8-(2	dimethyl-8-(2	ADJ
hjic-87	170	18	-	-	PUNCT
hjic-87	170	19	ethyl6	ethyl6	NOUN
hjic-87	170	20	-	-	PUNCT
hjic-87	170	21	methylbenzylamino)-3	methylbenzylamino)-3	PROPN
hjic-87	170	22	-	-	PUNCT
hjic-87	170	23	hydroxymethylimidazo[1,2	hydroxymethylimidazo[1,2	PROPN
hjic-87	170	24	-	-	PUNCT
hjic-87	170	25	a]pyridine	a]pyridine	NOUN
hjic-87	170	26	mesylate	mesylate	NOUN
hjic-87	170	27	and	and	CCONJ
hjic-87	170	28	two	two	NUM
hjic-87	170	29	excipients	excipient	NOUN
hjic-87	170	30	:	:	PUNCT
hjic-87	170	31	eudragit	eudragit	NOUN
hjic-87	170	32	e	e	NOUN
hjic-87	170	33	and	and	CCONJ
hjic-87	170	34	mannitol	mannitol	NOUN
hjic-87	170	35	[	[	X
hjic-87	170	36	69	69	NUM
hjic-87	170	37	]	]	PUNCT
hjic-87	170	38	.	.	PUNCT
hjic-87	171	1	although	although	SCONJ
hjic-87	171	2	mannitol	mannitol	NOUN
hjic-87	171	3	gave	give	VERB
hjic-87	171	4	no	no	DET
hjic-87	171	5	true	true	ADJ
hjic-87	171	6	one	one	NUM
hjic-87	171	7	-	-	PUNCT
hjic-87	171	8	phase	phase	NOUN
hjic-87	171	9	dispersion	dispersion	NOUN
hjic-87	171	10	(	(	PUNCT
hjic-87	171	11	solid	solid	ADJ
hjic-87	171	12	solution	solution	NOUN
hjic-87	171	13	)	)	PUNCT
hjic-87	171	14	it	it	PRON
hjic-87	171	15	improves	improve	VERB
hjic-87	171	16	the	the	DET
hjic-87	171	17	solubility	solubility	NOUN
hjic-87	171	18	of	of	ADP
hjic-87	171	19	the	the	DET
hjic-87	171	20	model	model	NOUN
hjic-87	171	21	drug	drug	NOUN
hjic-87	171	22	.	.	PUNCT
hjic-87	172	1	eudragit	eudragit	PROPN
hjic-87	172	2	e	e	PROPN
hjic-87	172	3	is	be	AUX
hjic-87	172	4	known	know	VERB
hjic-87	172	5	to	to	PART
hjic-87	172	6	inhibit	inhibit	VERB
hjic-87	172	7	crystallisation	crystallisation	NOUN
hjic-87	172	8	but	but	CCONJ
hjic-87	172	9	due	due	ADP
hjic-87	172	10	to	to	ADP
hjic-87	172	11	its	its	PRON
hjic-87	172	12	low	low	ADJ
hjic-87	172	13	glass	glass	NOUN
hjic-87	172	14	transition	transition	NOUN
hjic-87	172	15	temperature	temperature	NOUN
hjic-87	172	16	it	it	PRON
hjic-87	172	17	gives	give	VERB
hjic-87	172	18	no	no	DET
hjic-87	172	19	well	well	ADV
hjic-87	172	20	-	-	PUNCT
hjic-87	172	21	defined	define	VERB
hjic-87	172	22	particles	particle	NOUN
hjic-87	172	23	in	in	ADP
hjic-87	172	24	seds	sed	NOUN
hjic-87	172	25	and	and	CCONJ
hjic-87	172	26	can	can	AUX
hjic-87	172	27	dissolve	dissolve	VERB
hjic-87	172	28	in	in	ADP
hjic-87	172	29	scco2	scco2	ADJ
hjic-87	172	30	/	/	SYM
hjic-87	172	31	solvent	solvent	NOUN
hjic-87	172	32	mixture	mixture	NOUN
hjic-87	172	33	reducing	reduce	VERB
hjic-87	172	34	significantly	significantly	ADV
hjic-87	172	35	the	the	DET
hjic-87	172	36	yield	yield	NOUN
hjic-87	172	37	of	of	ADP
hjic-87	172	38	this	this	DET
hjic-87	172	39	method	method	NOUN
hjic-87	172	40	.	.	PUNCT
hjic-87	173	1	indeed	indeed	ADV
hjic-87	173	2	,	,	PUNCT
hjic-87	173	3	eudragit	eudragit	PROPN
hjic-87	173	4	e	e	PROPN
hjic-87	173	5	was	be	AUX
hjic-87	173	6	found	find	VERB
hjic-87	173	7	to	to	PART
hjic-87	173	8	form	form	VERB
hjic-87	173	9	amorphous	amorphous	ADJ
hjic-87	173	10	dispersion	dispersion	NOUN
hjic-87	173	11	,	,	PUNCT
hjic-87	173	12	but	but	CCONJ
hjic-87	173	13	with	with	ADP
hjic-87	173	14	extremely	extremely	ADV
hjic-87	173	15	low	low	ADJ
hjic-87	173	16	yield	yield	NOUN
hjic-87	173	17	(	(	PUNCT
hjic-87	173	18	<	<	X
hjic-87	173	19	20	20	NUM
hjic-87	173	20	%	%	NOUN
hjic-87	173	21	)	)	PUNCT
hjic-87	173	22	.	.	PUNCT
hjic-87	174	1	ghaderi	ghaderi	NOUN
hjic-87	174	2	et	et	PROPN
hjic-87	174	3	al	al	PROPN
hjic-87	174	4	.	.	PROPN
hjic-87	174	5	used	use	VERB
hjic-87	174	6	a	a	DET
hjic-87	174	7	combination	combination	NOUN
hjic-87	174	8	of	of	ADP
hjic-87	174	9	supercritical	supercritical	ADJ
hjic-87	174	10	n2	n2	NOUN
hjic-87	174	11	and	and	CCONJ
hjic-87	174	12	co2	co2	NOUN
hjic-87	174	13	to	to	PART
hjic-87	174	14	incorporate	incorporate	VERB
hjic-87	174	15	hydrocortisone	hydrocortisone	NOUN
hjic-87	174	16	in	in	ADP
hjic-87	174	17	plga	plga	NOUN
hjic-87	174	18	matrix	matrix	NOUN
hjic-87	174	19	.	.	PUNCT
hjic-87	175	1	microparticles	microparticle	NOUN
hjic-87	175	2	with	with	ADP
hjic-87	175	3	hydrocortisone	hydrocortisone	NOUN
hjic-87	175	4	were	be	AUX
hjic-87	175	5	more	more	ADV
hjic-87	175	6	irregular	irregular	ADJ
hjic-87	175	7	in	in	ADP
hjic-87	175	8	shape	shape	NOUN
hjic-87	175	9	,	,	PUNCT
hjic-87	175	10	but	but	CCONJ
hjic-87	175	11	differed	differ	VERB
hjic-87	175	12	slightly	slightly	ADV
hjic-87	175	13	in	in	ADP
hjic-87	175	14	size	size	NOUN
hjic-87	175	15	from	from	ADP
hjic-87	175	16	pure	pure	ADJ
hjic-87	175	17	plga	plga	NOUN
hjic-87	175	18	particles	particle	NOUN
hjic-87	175	19	[	[	X
hjic-87	175	20	70	70	NUM
hjic-87	175	21	]	]	PUNCT
hjic-87	175	22	.	.	PUNCT
hjic-87	176	1	table	table	NOUN
hjic-87	176	2	5	5	NUM
hjic-87	176	3	summary	summary	NOUN
hjic-87	176	4	of	of	ADP
hjic-87	176	5	drug	drug	NOUN
hjic-87	176	6	-	-	PUNCT
hjic-87	176	7	carrier	carrier	NOUN
hjic-87	176	8	systems	system	NOUN
hjic-87	176	9	precipitated	precipitate	VERB
hjic-87	176	10	by	by	ADP
hjic-87	176	11	seds	sed	NOUN
hjic-87	176	12	and	and	CCONJ
hjic-87	176	13	related	related	ADJ
hjic-87	176	14	methods	method	NOUN
hjic-87	176	15	.	.	PUNCT
hjic-87	177	1	substrate	substrate	NOUN
hjic-87	177	2	excipient	excipient	ADJ
hjic-87	177	3	observation	observation	NOUN
hjic-87	177	4	references	reference	NOUN
hjic-87	177	5	salmeterol	salmeterol	PROPN
hjic-87	177	6	xinafoate	xinafoate	PROPN
hjic-87	177	7	hpc	hpc	PROPN
hjic-87	177	8	cristalline	cristalline	PROPN
hjic-87	177	9	drug	drug	NOUN
hjic-87	177	10	enbedded	enbedde	VERB
hjic-87	177	11	in	in	ADP
hjic-87	177	12	polymer	polymer	NOUN
hjic-87	177	13	matrix	matrix	NOUN
hjic-87	177	14	[	[	X
hjic-87	177	15	63	63	NUM
hjic-87	177	16	]	]	SYM
hjic-87	177	17	hydrocortisone	hydrocortisone	PROPN
hjic-87	177	18	plga	plga	NOUN
hjic-87	177	19	microcapsules	microcapsule	NOUN
hjic-87	177	20	,	,	PUNCT
hjic-87	177	21	9	9	NUM
hjic-87	177	22	13	13	NUM
hjic-87	177	23	µm	µm	ADP
hjic-87	177	24	[	[	X
hjic-87	177	25	70	70	NUM
hjic-87	177	26	]	]	X
hjic-87	178	1	ec	ec	PROPN
hjic-87	178	2	ascorbi	ascorbi	NOUN
hjic-87	178	3	acid	acid	PROPN
hjic-87	178	4	hpmc	hpmc	PROPN
hjic-87	178	5	aggragated	aggragate	VERB
hjic-87	178	6	particles	particle	NOUN
hjic-87	178	7	,	,	PUNCT
hjic-87	178	8	0,5	0,5	NUM
hjic-87	178	9	µm	µm	ADP
hjic-87	178	10	ec	ec	PROPN
hjic-87	178	11	carbamazepine	carbamazepine	PROPN
hjic-87	178	12	hpmc	hpmc	PROPN
hjic-87	178	13	aggragated	aggragate	VERB
hjic-87	178	14	acicular	acicular	ADJ
hjic-87	178	15	particles	particle	NOUN
hjic-87	178	16	,	,	PUNCT
hjic-87	178	17	0,5	0,5	NUM
hjic-87	178	18	µm	µm	ADP
hjic-87	178	19	hpmc	hpmc	ADJ
hjic-87	178	20	amorphous	amorphous	ADJ
hjic-87	178	21	aggragates	aggragate	NOUN
hjic-87	178	22	and	and	CCONJ
hjic-87	178	23	fibers	fiber	NOUN
hjic-87	178	24	,	,	PUNCT
hjic-87	178	25	0,05	0,05	PROPN
hjic-87	178	26	1	1	NUM
hjic-87	178	27	µm	µm	ADP
hjic-87	178	28	ec	ec	PROPN
hjic-87	178	29	amorphous	amorphous	ADJ
hjic-87	178	30	particles	particle	NOUN
hjic-87	178	31	,	,	PUNCT
hjic-87	178	32	100	100	NUM
hjic-87	178	33	µm	µm	ADP
hjic-87	178	34	indomethacin	indomethacin	NOUN
hjic-87	178	35	pvp	pvp	VERB
hjic-87	178	36	amorphous	amorphous	ADJ
hjic-87	178	37	particles	particle	NOUN
hjic-87	178	38	,	,	PUNCT
hjic-87	178	39	10	10	NUM
hjic-87	178	40	250	250	NUM
hjic-87	178	41	µm	µm	ADP
hjic-87	178	42	hpmc	hpmc	ADJ
hjic-87	178	43	amorphous	amorphous	ADJ
hjic-87	178	44	aggragates	aggragate	NOUN
hjic-87	178	45	,	,	PUNCT
hjic-87	178	46	0,1	0,1	NUM
hjic-87	178	47	–	–	PUNCT
hjic-87	178	48	0,3	0,3	NUM
hjic-87	178	49	µm	µm	PART
hjic-87	178	50	ketoprofen	ketoprofen	VERB
hjic-87	178	51	ec	ec	PROPN
hjic-87	178	52	aggregates	aggregate	VERB
hjic-87	178	53	hpmc	hpmc	PROPN
hjic-87	178	54	amorphous	amorphous	ADJ
hjic-87	178	55	spheres	sphere	NOUN
hjic-87	178	56	,	,	PUNCT
hjic-87	178	57	3	3	NUM
hjic-87	178	58	–	–	PUNCT
hjic-87	178	59	200	200	NUM
hjic-87	178	60	µm	µm	ADP
hjic-87	178	61	paracetamol	paracetamol	NOUN
hjic-87	178	62	ec	ec	PROPN
hjic-87	178	63	fine	fine	ADJ
hjic-87	178	64	powder	powder	NOUN
hjic-87	178	65	hpmc	hpmc	PROPN
hjic-87	178	66	amorphous	amorphous	ADJ
hjic-87	178	67	aggragates	aggragate	NOUN
hjic-87	178	68	,	,	PUNCT
hjic-87	178	69	0,1	0,1	NUM
hjic-87	178	70	–	–	PUNCT
hjic-87	178	71	50	50	NUM
hjic-87	178	72	µm	µm	ADP
hjic-87	178	73	theophyline	theophyline	PROPN
hjic-87	178	74	ec	ec	PROPN
hjic-87	178	75	amorphous	amorphous	PROPN
hjic-87	178	76	aggragates	aggragates	PROPN
hjic-87	178	77	,	,	PUNCT
hjic-87	178	78	1	1	NUM
hjic-87	178	79	–	–	SYM
hjic-87	178	80	70	70	NUM
hjic-87	178	81	µm	µm	ADP
hjic-87	178	82	hpc	hpc	PROPN
hjic-87	178	83	model	model	NOUN
hjic-87	178	84	druga	druga	PROPN
hjic-87	178	85	poloxamer	poloxamer	PROPN
hjic-87	178	86	237	237	NUM
hjic-87	178	87	clusters	cluster	NOUN
hjic-87	178	88	and	and	CCONJ
hjic-87	178	89	agglomerates	agglomerate	NOUN
hjic-87	178	90	of	of	ADP
hjic-87	178	91	spheres	sphere	NOUN
hjic-87	178	92	,	,	PUNCT
hjic-87	178	93	2	2	NUM
hjic-87	178	94	–	–	SYM
hjic-87	178	95	32	32	NUM
hjic-87	178	96	µm	µm	ADP
hjic-87	178	97	model	model	NOUN
hjic-87	178	98	drugb	drugb	PROPN
hjic-87	178	99	hpc	hpc	PROPN
hjic-87	178	100	clusters	cluster	NOUN
hjic-87	178	101	and	and	CCONJ
hjic-87	178	102	irregular	irregular	ADJ
hjic-87	178	103	agglomerates	agglomerate	NOUN
hjic-87	178	104	,	,	PUNCT
hjic-87	178	105	4	4	NUM
hjic-87	178	106	–	–	PUNCT
hjic-87	178	107	47	47	NUM
hjic-87	178	108	µm	µm	PART
hjic-87	178	109	[	[	X
hjic-87	178	110	67	67	NUM
hjic-87	178	111	]	]	PUNCT
hjic-87	178	112	plasmid	plasmid	NOUN
hjic-87	178	113	-	-	PUNCT
hjic-87	178	114	dna	dna	NOUN
hjic-87	178	115	mannitol	mannitol	NOUN
hjic-87	178	116	dna	dna	NOUN
hjic-87	178	117	-	-	PUNCT
hjic-87	178	118	loaded	load	VERB
hjic-87	178	119	particles	particle	NOUN
hjic-87	178	120	[	[	X
hjic-87	178	121	71	71	NUM
hjic-87	178	122	]	]	PUNCT
hjic-87	178	123	chlorpheniramine	chlorpheniramine	NOUN
hjic-87	178	124	maleate	maleate	NOUN
hjic-87	178	125	eudragit	eudragit	X
hjic-87	178	126	rl	rl	ADP
hjic-87	178	127	drug	drug	NOUN
hjic-87	178	128	crystals	crystal	NOUN
hjic-87	178	129	incorporated	incorporate	VERB
hjic-87	178	130	in	in	ADP
hjic-87	178	131	swelled	swell	VERB
hjic-87	178	132	polymer	polymer	NOUN
hjic-87	178	133	[	[	X
hjic-87	178	134	72	72	NUM
hjic-87	178	135	]	]	PUNCT
hjic-87	178	136	mannitol	mannitol	NOUN
hjic-87	178	137	mixture	mixture	NOUN
hjic-87	178	138	of	of	ADP
hjic-87	178	139	drug	drug	NOUN
hjic-87	178	140	particles	particle	NOUN
hjic-87	178	141	and	and	CCONJ
hjic-87	178	142	polymer	polymer	NOUN
hjic-87	178	143	fibers	fiber	NOUN
hjic-87	178	144	,	,	PUNCT
hjic-87	178	145	1	1	NUM
hjic-87	178	146	20	20	NUM
hjic-87	178	147	µm	µm	NUM
hjic-87	178	148	model	model	NOUN
hjic-87	178	149	drugc	drugc	PROPN
hjic-87	178	150	eudragit	eudragit	PROPN
hjic-87	178	151	e	e	X
hjic-87	178	152	solid	solid	ADJ
hjic-87	178	153	solution	solution	NOUN
hjic-87	178	154	[	[	X
hjic-87	178	155	69	69	NUM
hjic-87	178	156	]	]	X
hjic-87	178	157	a	a	DET
hjic-87	178	158	(	(	PUNCT
hjic-87	178	159	(	(	PUNCT
hjic-87	178	160	z)-3-[1-(4	z)-3-[1-(4	ADV
hjic-87	178	161	-	-	PUNCT
hjic-87	178	162	chlorophenyl)-1-(4	chlorophenyl)-1-(4	ADJ
hjic-87	178	163	-	-	PUNCT
hjic-87	178	164	methansulfonyl)methylene]-dihydrofuran-2	methansulfonyl)methylene]-dihydrofuran-2	NOUN
hjic-87	178	165	-	-	PUNCT
hjic-87	178	166	one	one	NUM
hjic-87	178	167	)	)	PUNCT
hjic-87	178	168	;	;	PUNCT
hjic-87	178	169	b	b	X
hjic-87	178	170	(	(	PUNCT
hjic-87	178	171	(	(	PUNCT
hjic-87	178	172	z)-3-[1-(4	z)-3-[1-(4	X
hjic-87	178	173	-	-	PUNCT
hjic-87	178	174	bromophenyl)-1-(4	bromophenyl)-1-(4	NOUN
hjic-87	178	175	-	-	PUNCT
hjic-87	178	176	methansulfonyl)methylene]-dihydrofuran-2	methansulfonyl)methylene]-dihydrofuran-2	NOUN
hjic-87	178	177	-	-	PUNCT
hjic-87	178	178	one	one	NUM
hjic-87	178	179	)	)	PUNCT
hjic-87	178	180	;	;	PUNCT
hjic-87	178	181	c	c	PROPN
hjic-87	178	182	2,6	2,6	NUM
hjic-87	178	183	-	-	ADJ
hjic-87	178	184	dimethyl-8-(2	dimethyl-8-(2	ADJ
hjic-87	178	185	-	-	PUNCT
hjic-87	178	186	ethyl-6	ethyl-6	NOUN
hjic-87	178	187	-	-	PUNCT
hjic-87	178	188	methylbenzylamino)-3	methylbenzylamino)-3	PROPN
hjic-87	178	189	-	-	PUNCT
hjic-87	178	190	hydroxymethylimidazo-[1,2	hydroxymethylimidazo-[1,2	PROPN
hjic-87	178	191	-	-	PUNCT
hjic-87	178	192	a]pyridine	a]pyridine	NOUN
hjic-87	178	193	mesylate	mesylate	NOUN
hjic-87	178	194	;	;	PUNCT
hjic-87	178	195	49	49	NUM
hjic-87	178	196	fig	fig	NOUN
hjic-87	178	197	.	.	PUNCT
hjic-87	179	1	1	1	NUM
hjic-87	179	2	schematic	schematic	ADJ
hjic-87	179	3	diagram	diagram	NOUN
hjic-87	179	4	of	of	ADP
hjic-87	179	5	supercritical	supercritical	ADJ
hjic-87	179	6	particle	particle	NOUN
hjic-87	179	7	engineering	engineering	NOUN
hjic-87	179	8	technologies	technology	NOUN
hjic-87	179	9	.	.	PUNCT
hjic-87	180	1	particle	particle	NOUN
hjic-87	180	2	design	design	NOUN
hjic-87	180	3	using	use	VERB
hjic-87	180	4	liquefied	liquefy	VERB
hjic-87	180	5	gases	gas	NOUN
hjic-87	180	6	cryogenic	cryogenic	NOUN
hjic-87	180	7	particle	particle	NOUN
hjic-87	180	8	design	design	NOUN
hjic-87	180	9	is	be	AUX
hjic-87	180	10	present	present	ADJ
hjic-87	180	11	in	in	ADP
hjic-87	180	12	particle	particle	NOUN
hjic-87	180	13	engineering	engineering	NOUN
hjic-87	180	14	for	for	ADP
hjic-87	180	15	some	some	DET
hjic-87	180	16	30	30	NUM
hjic-87	180	17	years	year	NOUN
hjic-87	181	1	[	[	X
hjic-87	181	2	73	73	NUM
hjic-87	181	3	]	]	PUNCT
hjic-87	181	4	.	.	PUNCT
hjic-87	182	1	during	during	ADP
hjic-87	182	2	this	this	DET
hjic-87	182	3	period	period	NOUN
hjic-87	182	4	several	several	ADJ
hjic-87	182	5	invention	invention	NOUN
hjic-87	182	6	were	be	AUX
hjic-87	182	7	published	publish	VERB
hjic-87	182	8	and	and	CCONJ
hjic-87	182	9	patented	patent	VERB
hjic-87	182	10	.	.	PUNCT
hjic-87	183	1	all	all	PRON
hjic-87	183	2	of	of	ADP
hjic-87	183	3	these	these	DET
hjic-87	183	4	methods	method	NOUN
hjic-87	183	5	take	take	VERB
hjic-87	183	6	advantage	advantage	NOUN
hjic-87	183	7	of	of	ADP
hjic-87	183	8	instantaneous	instantaneous	ADJ
hjic-87	183	9	freezing	freezing	NOUN
hjic-87	183	10	of	of	ADP
hjic-87	183	11	a	a	DET
hjic-87	183	12	solution	solution	NOUN
hjic-87	183	13	or	or	CCONJ
hjic-87	183	14	suspension	suspension	NOUN
hjic-87	183	15	dispersed	disperse	VERB
hjic-87	183	16	in	in	ADP
hjic-87	183	17	cryogenic	cryogenic	ADJ
hjic-87	183	18	fluid	fluid	NOUN
hjic-87	183	19	.	.	PUNCT
hjic-87	184	1	inventions	invention	NOUN
hjic-87	184	2	can	can	AUX
hjic-87	184	3	be	be	AUX
hjic-87	184	4	classified	classify	VERB
hjic-87	184	5	by	by	ADP
hjic-87	184	6	the	the	DET
hjic-87	184	7	type	type	NOUN
hjic-87	184	8	of	of	ADP
hjic-87	184	9	injection	injection	NOUN
hjic-87	184	10	device	device	NOUN
hjic-87	184	11	:	:	PUNCT
hjic-87	184	12	type	type	NOUN
hjic-87	184	13	of	of	ADP
hjic-87	184	14	nozzle	nozzle	NOUN
hjic-87	184	15	(	(	PUNCT
hjic-87	184	16	capillary	capillary	ADJ
hjic-87	184	17	,	,	PUNCT
hjic-87	184	18	rotary	rotary	NOUN
hjic-87	184	19	,	,	PUNCT
hjic-87	184	20	pneumatic	pneumatic	ADJ
hjic-87	184	21	,	,	PUNCT
hjic-87	184	22	ultrasonic	ultrasonic	ADJ
hjic-87	184	23	)	)	PUNCT
hjic-87	184	24	,	,	PUNCT
hjic-87	184	25	location	location	NOUN
hjic-87	184	26	of	of	ADP
hjic-87	184	27	nozzle	nozzle	NOUN
hjic-87	184	28	(	(	PUNCT
hjic-87	184	29	above	above	ADP
hjic-87	184	30	or	or	CCONJ
hjic-87	184	31	under	under	ADP
hjic-87	184	32	the	the	DET
hjic-87	184	33	liquid	liquid	ADJ
hjic-87	184	34	level	level	NOUN
hjic-87	184	35	)	)	PUNCT
hjic-87	184	36	;	;	PUNCT
hjic-87	184	37	and	and	CCONJ
hjic-87	184	38	the	the	DET
hjic-87	184	39	composition	composition	NOUN
hjic-87	184	40	of	of	ADP
hjic-87	184	41	cryogenic	cryogenic	ADJ
hjic-87	184	42	liquid	liquid	NOUN
hjic-87	184	43	(	(	PUNCT
hjic-87	184	44	hydrofluoroalkanes	hydrofluoroalkane	NOUN
hjic-87	184	45	,	,	PUNCT
hjic-87	184	46	n2(l	n2(l	NOUN
hjic-87	184	47	)	)	PUNCT
hjic-87	184	48	,	,	PUNCT
hjic-87	184	49	ar(l	ar(l	NUM
hjic-87	184	50	)	)	PUNCT
hjic-87	184	51	,	,	PUNCT
hjic-87	184	52	o2(l	o2(l	NOUN
hjic-87	184	53	)	)	PUNCT
hjic-87	184	54	,	,	PUNCT
hjic-87	184	55	organic	organic	ADJ
hjic-87	184	56	solvents	solvent	NOUN
hjic-87	184	57	)	)	PUNCT
hjic-87	184	58	.	.	PUNCT
hjic-87	185	1	first	first	ADV
hjic-87	185	2	we	we	PRON
hjic-87	185	3	considered	consider	VERB
hjic-87	185	4	the	the	DET
hjic-87	185	5	techniques	technique	NOUN
hjic-87	185	6	where	where	SCONJ
hjic-87	185	7	the	the	DET
hjic-87	185	8	orifice	orifice	NOUN
hjic-87	185	9	is	be	AUX
hjic-87	185	10	located	locate	VERB
hjic-87	185	11	above	above	ADP
hjic-87	185	12	the	the	DET
hjic-87	185	13	liquid	liquid	ADJ
hjic-87	185	14	surface	surface	NOUN
hjic-87	185	15	,	,	PUNCT
hjic-87	185	16	afterwards	afterwards	ADV
hjic-87	185	17	those	those	PRON
hjic-87	185	18	of	of	ADP
hjic-87	185	19	immersed	immersed	ADJ
hjic-87	185	20	nozzle	nozzle	NOUN
hjic-87	185	21	.	.	PUNCT
hjic-87	186	1	briggs	briggs	PROPN
hjic-87	186	2	and	and	CCONJ
hjic-87	186	3	maxwell	maxwell	PROPN
hjic-87	186	4	invented	invent	VERB
hjic-87	186	5	the	the	DET
hjic-87	186	6	first	first	ADJ
hjic-87	186	7	process	process	NOUN
hjic-87	186	8	of	of	ADP
hjic-87	186	9	spray	spray	NOUN
hjic-87	186	10	freezing	freeze	VERB
hjic-87	186	11	onto	onto	ADP
hjic-87	186	12	cryogenic	cryogenic	NOUN
hjic-87	186	13	fluid	fluid	NOUN
hjic-87	186	14	.	.	PUNCT
hjic-87	187	1	their	their	PRON
hjic-87	187	2	first	first	ADJ
hjic-87	187	3	patent	patent	NOUN
hjic-87	187	4	dates	date	VERB
hjic-87	187	5	back	back	ADV
hjic-87	187	6	to	to	ADP
hjic-87	187	7	1973	1973	NUM
hjic-87	187	8	wherein	wherein	SCONJ
hjic-87	187	9	the	the	DET
hjic-87	187	10	authors	author	NOUN
hjic-87	187	11	described	describe	VERB
hjic-87	187	12	a	a	DET
hjic-87	187	13	process	process	NOUN
hjic-87	187	14	of	of	ADP
hjic-87	187	15	blending	blend	VERB
hjic-87	187	16	a	a	DET
hjic-87	187	17	solid	solid	ADJ
hjic-87	187	18	biological	biological	ADJ
hjic-87	187	19	product	product	NOUN
hjic-87	187	20	with	with	ADP
hjic-87	187	21	solid	solid	ADJ
hjic-87	187	22	sugar	sugar	NOUN
hjic-87	188	1	[	[	X
hjic-87	188	2	74	74	NUM
hjic-87	188	3	]	]	PUNCT
hjic-87	188	4	.	.	PUNCT
hjic-87	189	1	the	the	DET
hjic-87	189	2	chosen	choose	VERB
hjic-87	189	3	api	api	NOUN
hjic-87	189	4	together	together	ADV
hjic-87	189	5	with	with	ADP
hjic-87	189	6	the	the	DET
hjic-87	189	7	carrier	carrier	NOUN
hjic-87	189	8	sugar	sugar	NOUN
hjic-87	189	9	(	(	PUNCT
hjic-87	189	10	mannitol	mannitol	NOUN
hjic-87	189	11	,	,	PUNCT
hjic-87	189	12	maltose	maltose	NOUN
hjic-87	189	13	,	,	PUNCT
hjic-87	189	14	lactose	lactose	NOUN
hjic-87	189	15	,	,	PUNCT
hjic-87	189	16	inositol	inositol	NOUN
hjic-87	189	17	or	or	CCONJ
hjic-87	189	18	dextran	dextran	NOUN
hjic-87	189	19	)	)	PUNCT
hjic-87	189	20	were	be	AUX
hjic-87	189	21	dissolved	dissolve	VERB
hjic-87	189	22	in	in	ADP
hjic-87	189	23	water	water	NOUN
hjic-87	189	24	and	and	CCONJ
hjic-87	189	25	atomized	atomize	VERB
hjic-87	189	26	above	above	ADP
hjic-87	189	27	the	the	DET
hjic-87	189	28	surface	surface	NOUN
hjic-87	189	29	of	of	ADP
hjic-87	189	30	a	a	DET
hjic-87	189	31	boiling	boil	VERB
hjic-87	189	32	agitated	agitated	ADJ
hjic-87	189	33	fluorocarbon	fluorocarbon	NOUN
hjic-87	189	34	refrigerant	refrigerant	NOUN
hjic-87	189	35	.	.	PUNCT
hjic-87	190	1	to	to	PART
hjic-87	190	2	enhance	enhance	VERB
hjic-87	190	3	the	the	DET
hjic-87	190	4	dispersion	dispersion	NOUN
hjic-87	190	5	of	of	ADP
hjic-87	190	6	the	the	DET
hjic-87	190	7	aqueous	aqueous	ADJ
hjic-87	190	8	solution	solution	NOUN
hjic-87	190	9	authors	author	NOUN
hjic-87	190	10	placed	place	VERB
hjic-87	190	11	a	a	DET
hjic-87	190	12	sonication	sonication	NOUN
hjic-87	190	13	probe	probe	NOUN
hjic-87	190	14	in	in	ADP
hjic-87	190	15	the	the	DET
hjic-87	190	16	stirred	stir	VERB
hjic-87	190	17	refrigerant	refrigerant	NOUN
hjic-87	190	18	.	.	PUNCT
hjic-87	191	1	solid	solid	ADJ
hjic-87	191	2	particles	particle	NOUN
hjic-87	191	3	were	be	AUX
hjic-87	191	4	collected	collect	VERB
hjic-87	191	5	with	with	ADP
hjic-87	191	6	a	a	DET
hjic-87	191	7	sieve	sieve	NOUN
hjic-87	191	8	and	and	CCONJ
hjic-87	191	9	lyphilized	lyphilize	VERB
hjic-87	191	10	.	.	PUNCT
hjic-87	192	1	freon	freon	NOUN
hjic-87	192	2	12	12	NUM
hjic-87	192	3	(	(	PUNCT
hjic-87	192	4	dichlorodifluoromethane	dichlorodifluoromethane	PROPN
hjic-87	192	5	)	)	PUNCT
hjic-87	192	6	was	be	AUX
hjic-87	192	7	found	find	VERB
hjic-87	192	8	suitable	suitable	ADJ
hjic-87	192	9	for	for	ADP
hjic-87	192	10	this	this	DET
hjic-87	192	11	purpose	purpose	NOUN
hjic-87	192	12	because	because	SCONJ
hjic-87	192	13	its	its	PRON
hjic-87	192	14	boiling	boiling	NOUN
hjic-87	192	15	point	point	NOUN
hjic-87	192	16	(	(	PUNCT
hjic-87	192	17	tb=	tb=	NOUN
hjic-87	192	18	-30	-30	PUNCT
hjic-87	192	19	°	°	PROPN
hjic-87	192	20	c	c	NOUN
hjic-87	192	21	)	)	PUNCT
hjic-87	192	22	is	be	AUX
hjic-87	192	23	sufficiently	sufficiently	ADV
hjic-87	192	24	low	low	ADJ
hjic-87	192	25	to	to	PART
hjic-87	192	26	cause	cause	VERB
hjic-87	192	27	instantaneous	instantaneous	ADJ
hjic-87	192	28	freezing	freezing	NOUN
hjic-87	192	29	,	,	PUNCT
hjic-87	192	30	but	but	CCONJ
hjic-87	192	31	not	not	PART
hjic-87	192	32	enough	enough	ADV
hjic-87	192	33	low	low	ADJ
hjic-87	192	34	to	to	PART
hjic-87	192	35	form	form	VERB
hjic-87	192	36	an	an	DET
hjic-87	192	37	extensive	extensive	ADJ
hjic-87	192	38	"	"	PUNCT
hjic-87	192	39	vapor	vapor	NOUN
hjic-87	192	40	barrier	barrier	NOUN
hjic-87	192	41	"	"	PUNCT
hjic-87	192	42	around	around	ADP
hjic-87	192	43	the	the	DET
hjic-87	192	44	droplets	droplet	NOUN
hjic-87	192	45	which	which	PRON
hjic-87	192	46	would	would	AUX
hjic-87	192	47	hinder	hinder	VERB
hjic-87	192	48	fast	fast	ADJ
hjic-87	192	49	freezing	freezing	NOUN
hjic-87	192	50	.	.	PUNCT
hjic-87	193	1	several	several	ADJ
hjic-87	193	2	apis	api	NOUN
hjic-87	193	3	were	be	AUX
hjic-87	193	4	blended	blend	VERB
hjic-87	193	5	by	by	ADP
hjic-87	193	6	this	this	DET
hjic-87	193	7	method	method	NOUN
hjic-87	193	8	including	include	VERB
hjic-87	193	9	proteins	protein	NOUN
hjic-87	193	10	,	,	PUNCT
hjic-87	193	11	pharmaceuticals	pharmaceutical	NOUN
hjic-87	193	12	and	and	CCONJ
hjic-87	193	13	enzymes	enzyme	NOUN
hjic-87	193	14	(	(	PUNCT
hjic-87	193	15	luciferase	luciferase	ADJ
hjic-87	193	16	,	,	PUNCT
hjic-87	193	17	hexokinase	hexokinase	NOUN
hjic-87	193	18	,	,	PUNCT
hjic-87	193	19	glucose-6	glucose-6	NOUN
hjic-87	193	20	-	-	PUNCT
hjic-87	193	21	phosphate	phosphate	NOUN
hjic-87	193	22	dehydrogenase	dehydrogenase	NOUN
hjic-87	193	23	(	(	PUNCT
hjic-87	193	24	g-6	g-6	NOUN
hjic-87	193	25	-	-	PUNCT
hjic-87	193	26	pdh	pdh	NOUN
hjic-87	193	27	)	)	PUNCT
hjic-87	193	28	,	,	PUNCT
hjic-87	193	29	lactate	lactate	NOUN
hjic-87	193	30	dehydrogenase	dehydrogenase	NOUN
hjic-87	193	31	(	(	PUNCT
hjic-87	193	32	ldh	ldh	NOUN
hjic-87	193	33	)	)	PUNCT
hjic-87	193	34	,	,	PUNCT
hjic-87	193	35	pyruvate	pyruvate	NOUN
hjic-87	193	36	kinase	kinase	NOUN
hjic-87	193	37	;	;	PUNCT
hjic-87	193	38	luciferin	luciferin	NOUN
hjic-87	193	39	,	,	PUNCT
hjic-87	193	40	bovine	bovine	NOUN
hjic-87	193	41	albumin	albumin	NOUN
hjic-87	193	42	,	,	PUNCT
hjic-87	193	43	morpholinopropane	morpholinopropane	NOUN
hjic-87	193	44	sulfonic	sulfonic	ADJ
hjic-87	193	45	acid	acid	NOUN
hjic-87	193	46	(	(	PUNCT
hjic-87	193	47	mops	mop	NOUN
hjic-87	193	48	)	)	PUNCT
hjic-87	193	49	,	,	PUNCT
hjic-87	193	50	2,6dichlorophenol	2,6dichlorophenol	NUM
hjic-87	193	51	indophenol	indophenol	NOUN
hjic-87	193	52	(	(	PUNCT
hjic-87	193	53	dip	dip	NOUN
hjic-87	193	54	)	)	PUNCT
hjic-87	193	55	,	,	PUNCT
hjic-87	193	56	nicotinamideadeninine	nicotinamideadeninine	NOUN
hjic-87	193	57	-	-	PUNCT
hjic-87	193	58	dinucleotide	dinucleotide	NOUN
hjic-87	193	59	(	(	PUNCT
hjic-87	193	60	nad	nad	NOUN
hjic-87	193	61	)	)	PUNCT
hjic-87	193	62	and	and	CCONJ
hjic-87	193	63	its	its	PRON
hjic-87	193	64	reduced	reduced	ADJ
hjic-87	193	65	derivative	derivative	ADJ
hjic-87	193	66	(	(	PUNCT
hjic-87	193	67	nadh	nadh	NOUN
hjic-87	193	68	)	)	PUNCT
hjic-87	193	69	.	.	PUNCT
hjic-87	194	1	in	in	ADP
hjic-87	194	2	the	the	DET
hjic-87	194	3	following	follow	VERB
hjic-87	194	4	two	two	NUM
hjic-87	194	5	patents	patent	NOUN
hjic-87	194	6	,	,	PUNCT
hjic-87	194	7	the	the	DET
hjic-87	194	8	authors	author	NOUN
hjic-87	194	9	completed	complete	VERB
hjic-87	194	10	the	the	DET
hjic-87	194	11	above	above	ADJ
hjic-87	194	12	list	list	NOUN
hjic-87	194	13	of	of	ADP
hjic-87	194	14	apis	apis	PROPN
hjic-87	194	15	with	with	ADP
hjic-87	194	16	blood	blood	NOUN
hjic-87	194	17	serum	serum	NOUN
hjic-87	194	18	,	,	PUNCT
hjic-87	194	19	red	red	ADJ
hjic-87	194	20	blood	blood	NOUN
hjic-87	194	21	cells	cell	NOUN
hjic-87	194	22	,	,	PUNCT
hjic-87	194	23	bacitracin	bacitracin	NOUN
hjic-87	194	24	,	,	PUNCT
hjic-87	194	25	polymyxin	polymyxin	NOUN
hjic-87	194	26	b	b	PROPN
hjic-87	194	27	,	,	PUNCT
hjic-87	194	28	tetracycline	tetracycline	NOUN
hjic-87	194	29	,	,	PUNCT
hjic-87	194	30	chlorpromazine	chlorpromazine	NOUN
hjic-87	194	31	,	,	PUNCT
hjic-87	194	32	maltase	maltase	NOUN
hjic-87	194	33	enzyme	enzyme	NOUN
hjic-87	194	34	,	,	PUNCT
hjic-87	194	35	testosterone	testosterone	NOUN
hjic-87	194	36	,	,	PUNCT
hjic-87	194	37	vitamin	vitamin	NOUN
hjic-87	194	38	c	c	NOUN
hjic-87	194	39	,	,	PUNCT
hjic-87	194	40	cholesterol	cholesterol	NOUN
hjic-87	194	41	and	and	CCONJ
hjic-87	194	42	gelatin	gelatin	NOUN
hjic-87	194	43	[	[	X
hjic-87	194	44	75,76	75,76	NOUN
hjic-87	194	45	]	]	PUNCT
hjic-87	194	46	.	.	PUNCT
hjic-87	195	1	processed	process	VERB
hjic-87	195	2	materials	material	NOUN
hjic-87	195	3	were	be	AUX
hjic-87	195	4	characterized	characterize	VERB
hjic-87	195	5	by	by	ADP
hjic-87	195	6	high	high	ADJ
hjic-87	195	7	biological	biological	ADJ
hjic-87	195	8	activity	activity	NOUN
hjic-87	195	9	,	,	PUNCT
hjic-87	195	10	homogeneity	homogeneity	NOUN
hjic-87	195	11	and	and	CCONJ
hjic-87	195	12	stability	stability	NOUN
hjic-87	195	13	.	.	PUNCT
hjic-87	196	1	in	in	ADP
hjic-87	196	2	1980	1980	NUM
hjic-87	196	3	adams	adam	NOUN
hjic-87	196	4	et	et	PROPN
hjic-87	196	5	al	al	PROPN
hjic-87	196	6	.	.	PROPN
hjic-87	196	7	patented	patent	VERB
hjic-87	196	8	a	a	DET
hjic-87	196	9	method	method	NOUN
hjic-87	196	10	similar	similar	ADJ
hjic-87	196	11	to	to	ADP
hjic-87	196	12	the	the	DET
hjic-87	196	13	one	one	NUM
hjic-87	196	14	of	of	ADP
hjic-87	196	15	briggs	briggs	PROPN
hjic-87	196	16	and	and	CCONJ
hjic-87	196	17	maxwell	maxwell	PROPN
hjic-87	196	18	with	with	ADP
hjic-87	196	19	the	the	DET
hjic-87	196	20	slight	slight	ADJ
hjic-87	196	21	difference	difference	NOUN
hjic-87	196	22	that	that	PRON
hjic-87	196	23	they	they	PRON
hjic-87	196	24	used	use	VERB
hjic-87	196	25	needle	needle	NOUN
hjic-87	196	26	(	(	PUNCT
hjic-87	196	27	capillary	capillary	ADJ
hjic-87	196	28	)	)	PUNCT
hjic-87	196	29	nozzles	nozzle	NOUN
hjic-87	196	30	to	to	PART
hjic-87	196	31	disperse	disperse	VERB
hjic-87	196	32	the	the	DET
hjic-87	196	33	solution	solution	NOUN
hjic-87	196	34	or	or	CCONJ
hjic-87	196	35	suspension	suspension	NOUN
hjic-87	196	36	onto	onto	ADP
hjic-87	196	37	the	the	DET
hjic-87	196	38	surface	surface	NOUN
hjic-87	196	39	of	of	ADP
hjic-87	196	40	stirred	stir	VERB
hjic-87	196	41	halocarbon	halocarbon	PROPN
hjic-87	196	42	refrigerant	refrigerant	NOUN
hjic-87	197	1	[	[	X
hjic-87	197	2	77,78	77,78	NOUN
hjic-87	197	3	]	]	X
hjic-87	197	4	(	(	PUNCT
hjic-87	197	5	see	see	VERB
hjic-87	197	6	fig	fig	NOUN
hjic-87	197	7	.	.	PUNCT
hjic-87	198	1	2	2	NUM
hjic-87	198	2	)	)	PUNCT
hjic-87	198	3	.	.	PUNCT
hjic-87	199	1	blood	blood	NOUN
hjic-87	199	2	plasma	plasma	NOUN
hjic-87	199	3	particles	particle	NOUN
hjic-87	199	4	processed	process	VERB
hjic-87	199	5	in	in	ADP
hjic-87	199	6	freon	freon	NOUN
hjic-87	199	7	12	12	NUM
hjic-87	199	8	ranged	range	VERB
hjic-87	199	9	from	from	ADP
hjic-87	199	10	0.84	0.84	NUM
hjic-87	199	11	to	to	ADP
hjic-87	199	12	1.68	1.68	NUM
hjic-87	199	13	mm	mm	NOUN
hjic-87	199	14	in	in	ADP
hjic-87	199	15	diameter	diameter	NOUN
hjic-87	199	16	.	.	PUNCT
hjic-87	200	1	fig	fig	NOUN
hjic-87	200	2	.	.	PUNCT
hjic-87	201	1	2	2	NUM
hjic-87	201	2	schematic	schematic	ADJ
hjic-87	201	3	diagram	diagram	NOUN
hjic-87	201	4	of	of	ADP
hjic-87	201	5	the	the	DET
hjic-87	201	6	apparatus	apparatus	NOUN
hjic-87	201	7	invented	invent	VERB
hjic-87	201	8	by	by	ADP
hjic-87	201	9	adams	adams	PROPN
hjic-87	201	10	et	et	PROPN
hjic-87	201	11	al	al	PROPN
hjic-87	201	12	.	.	PROPN
hjic-87	201	13	1	1	NUM
hjic-87	201	14	.	.	X
hjic-87	201	15	refrigerant	refrigerant	ADJ
hjic-87	201	16	;	;	PUNCT
hjic-87	201	17	2	2	X
hjic-87	201	18	.	.	NUM
hjic-87	201	19	rotated	rotate	VERB
hjic-87	201	20	vessel	vessel	NOUN
hjic-87	201	21	;	;	PUNCT
hjic-87	201	22	3	3	X
hjic-87	201	23	.	.	X
hjic-87	201	24	nozzles	nozzle	NOUN
hjic-87	201	25	;	;	PUNCT
hjic-87	201	26	4	4	NUM
hjic-87	201	27	.	.	NOUN
hjic-87	201	28	wire	wire	NOUN
hjic-87	201	29	screen	screen	NOUN
hjic-87	201	30	;	;	PUNCT
hjic-87	201	31	5	5	X
hjic-87	201	32	.	.	X
hjic-87	201	33	condenser	condenser	PROPN
hjic-87	201	34	hebert	hebert	PROPN
hjic-87	201	35	et	et	PROPN
hjic-87	201	36	al	al	PROPN
hjic-87	201	37	.	.	PROPN
hjic-87	202	1	prepared	prepared	ADJ
hjic-87	202	2	microparticles	microparticle	NOUN
hjic-87	202	3	of	of	ADP
hjic-87	202	4	controlled	control	VERB
hjic-87	202	5	release	release	NOUN
hjic-87	202	6	device	device	NOUN
hjic-87	202	7	by	by	ADP
hjic-87	202	8	spraying	spray	VERB
hjic-87	202	9	the	the	DET
hjic-87	202	10	solution	solution	NOUN
hjic-87	202	11	containing	contain	VERB
hjic-87	202	12	an	an	DET
hjic-87	202	13	api	api	NOUN
hjic-87	202	14	and	and	CCONJ
hjic-87	202	15	a	a	DET
hjic-87	202	16	biodegradable	biodegradable	ADJ
hjic-87	202	17	polymer	polymer	NOUN
hjic-87	202	18	into	into	ADP
hjic-87	202	19	cold	cold	ADJ
hjic-87	202	20	nitrogen	nitrogen	NOUN
hjic-87	202	21	gas	gas	NOUN
hjic-87	203	1	[	[	X
hjic-87	203	2	79	79	NUM
hjic-87	203	3	]	]	PUNCT
hjic-87	203	4	(	(	PUNCT
hjic-87	203	5	see	see	VERB
hjic-87	203	6	fig	fig	NOUN
hjic-87	203	7	.	.	PUNCT
hjic-87	204	1	3	3	NUM
hjic-87	204	2	)	)	PUNCT
hjic-87	204	3	.	.	PUNCT
hjic-87	205	1	particles	particle	NOUN
hjic-87	205	2	50	50	NUM
hjic-87	205	3	were	be	AUX
hjic-87	205	4	frozen	freeze	VERB
hjic-87	205	5	partially	partially	ADV
hjic-87	205	6	in	in	ADP
hjic-87	205	7	the	the	DET
hjic-87	205	8	gaseous	gaseous	ADJ
hjic-87	205	9	phase	phase	NOUN
hjic-87	205	10	and	and	CCONJ
hjic-87	205	11	collected	collect	VERB
hjic-87	205	12	in	in	ADP
hjic-87	205	13	the	the	DET
hjic-87	205	14	liquid	liquid	ADJ
hjic-87	205	15	phase	phase	NOUN
hjic-87	205	16	at	at	ADP
hjic-87	205	17	the	the	DET
hjic-87	205	18	bottom	bottom	NOUN
hjic-87	205	19	of	of	ADP
hjic-87	205	20	the	the	DET
hjic-87	205	21	vessel	vessel	NOUN
hjic-87	205	22	where	where	SCONJ
hjic-87	205	23	they	they	PRON
hjic-87	205	24	solidified	solidify	VERB
hjic-87	205	25	completely	completely	ADV
hjic-87	205	26	.	.	PUNCT
hjic-87	206	1	in	in	ADP
hjic-87	206	2	a	a	DET
hjic-87	206	3	second	second	ADJ
hjic-87	206	4	vessel	vessel	NOUN
hjic-87	206	5	liquid	liquid	ADJ
hjic-87	206	6	nitrogen	nitrogen	NOUN
hjic-87	206	7	was	be	AUX
hjic-87	206	8	evaporated	evaporate	VERB
hjic-87	206	9	and	and	CCONJ
hjic-87	206	10	residual	residual	ADJ
hjic-87	206	11	organic	organic	ADJ
hjic-87	206	12	solvent	solvent	NOUN
hjic-87	206	13	is	be	AUX
hjic-87	206	14	removed	remove	VERB
hjic-87	206	15	by	by	ADP
hjic-87	206	16	extraction	extraction	NOUN
hjic-87	206	17	.	.	PUNCT
hjic-87	207	1	fig	fig	NOUN
hjic-87	207	2	.	.	PUNCT
hjic-87	208	1	3	3	NUM
hjic-87	208	2	schematic	schematic	ADJ
hjic-87	208	3	diagram	diagram	NOUN
hjic-87	208	4	of	of	ADP
hjic-87	208	5	the	the	DET
hjic-87	208	6	apparatus	apparatus	NOUN
hjic-87	208	7	invented	invent	VERB
hjic-87	208	8	by	by	ADP
hjic-87	208	9	hebert	hebert	PROPN
hjic-87	208	10	et	et	PROPN
hjic-87	208	11	al	al	PROPN
hjic-87	208	12	.	.	PROPN
hjic-87	208	13	1	1	X
hjic-87	208	14	.	.	X
hjic-87	208	15	freezing	freeze	VERB
hjic-87	208	16	vessel	vessel	NOUN
hjic-87	208	17	;	;	PUNCT
hjic-87	208	18	2	2	X
hjic-87	208	19	.	.	X
hjic-87	208	20	extraction	extraction	NOUN
hjic-87	208	21	vessel	vessel	NOUN
hjic-87	208	22	;	;	PUNCT
hjic-87	208	23	3	3	X
hjic-87	208	24	.	.	X
hjic-87	208	25	nozzle	nozzle	NOUN
hjic-87	208	26	;	;	PUNCT
hjic-87	208	27	4.liquified	4.liquified	NUM
hjic-87	208	28	gas	gas	NOUN
hjic-87	208	29	inlet	inlet	NOUN
hjic-87	208	30	;	;	PUNCT
hjic-87	208	31	5	5	X
hjic-87	208	32	.	.	X
hjic-87	208	33	mixing	mixing	NOUN
hjic-87	208	34	means	mean	NOUN
hjic-87	208	35	gombotz	gombotz	PROPN
hjic-87	208	36	et	et	PROPN
hjic-87	208	37	al	al	PROPN
hjic-87	208	38	.	.	PROPN
hjic-87	208	39	patented	patent	VERB
hjic-87	208	40	a	a	DET
hjic-87	208	41	similar	similar	ADJ
hjic-87	208	42	process	process	NOUN
hjic-87	208	43	to	to	PART
hjic-87	208	44	prepare	prepare	VERB
hjic-87	208	45	microparticles	microparticle	NOUN
hjic-87	208	46	of	of	ADP
hjic-87	208	47	biodegradable	biodegradable	ADJ
hjic-87	208	48	polymers	polymer	NOUN
hjic-87	208	49	wherein	wherein	SCONJ
hjic-87	208	50	the	the	DET
hjic-87	208	51	solution	solution	NOUN
hjic-87	208	52	of	of	ADP
hjic-87	208	53	api	api	NOUN
hjic-87	208	54	is	be	AUX
hjic-87	208	55	atomized	atomize	VERB
hjic-87	208	56	directly	directly	ADV
hjic-87	208	57	into	into	ADP
hjic-87	208	58	liquid	liquid	ADJ
hjic-87	208	59	non	non	ADJ
hjic-87	208	60	-	-	ADJ
hjic-87	208	61	solvent	solvent	ADJ
hjic-87	208	62	or	or	CCONJ
hjic-87	208	63	in	in	ADP
hjic-87	208	64	liquified	liquified	ADJ
hjic-87	208	65	gas	gas	NOUN
hjic-87	208	66	containing	contain	VERB
hjic-87	208	67	frozen	frozen	ADJ
hjic-87	208	68	non	non	ADJ
hjic-87	208	69	-	-	NOUN
hjic-87	208	70	solvent	solvent	ADJ
hjic-87	208	71	at	at	ADP
hjic-87	208	72	a	a	DET
hjic-87	208	73	temperature	temperature	NOUN
hjic-87	208	74	below	below	ADP
hjic-87	208	75	the	the	DET
hjic-87	208	76	melting	melting	NOUN
hjic-87	208	77	point	point	NOUN
hjic-87	208	78	of	of	ADP
hjic-87	208	79	the	the	DET
hjic-87	208	80	solution	solution	NOUN
hjic-87	208	81	[	[	X
hjic-87	208	82	80	80	NUM
hjic-87	208	83	]	]	PUNCT
hjic-87	208	84	.	.	PUNCT
hjic-87	209	1	the	the	DET
hjic-87	209	2	solvent	solvent	NOUN
hjic-87	209	3	in	in	ADP
hjic-87	209	4	the	the	DET
hjic-87	209	5	microspheres	microsphere	NOUN
hjic-87	209	6	then	then	ADV
hjic-87	209	7	thaws	thaw	VERB
hjic-87	209	8	and	and	CCONJ
hjic-87	209	9	is	be	AUX
hjic-87	209	10	slowly	slowly	ADV
hjic-87	209	11	extracted	extract	VERB
hjic-87	209	12	by	by	ADP
hjic-87	209	13	the	the	DET
hjic-87	209	14	non	non	ADJ
hjic-87	209	15	-	-	NOUN
hjic-87	209	16	solvent	solvent	ADJ
hjic-87	209	17	.	.	PUNCT
hjic-87	210	1	however	however	ADV
hjic-87	210	2	,	,	PUNCT
hjic-87	210	3	it	it	PRON
hjic-87	210	4	can	can	AUX
hjic-87	210	5	be	be	AUX
hjic-87	210	6	difficult	difficult	ADJ
hjic-87	210	7	to	to	PART
hjic-87	210	8	find	find	VERB
hjic-87	210	9	a	a	DET
hjic-87	210	10	good	good	ADJ
hjic-87	210	11	solvent	solvent	NOUN
hjic-87	210	12	,	,	PUNCT
hjic-87	210	13	which	which	PRON
hjic-87	210	14	extracts	extract	VERB
hjic-87	210	15	exclusively	exclusively	ADV
hjic-87	210	16	the	the	DET
hjic-87	210	17	organic	organic	ADJ
hjic-87	210	18	solvent	solvent	NOUN
hjic-87	210	19	,	,	PUNCT
hjic-87	210	20	and	and	CCONJ
hjic-87	210	21	residual	residual	ADJ
hjic-87	210	22	organic	organic	ADJ
hjic-87	210	23	traces	trace	NOUN
hjic-87	210	24	are	be	AUX
hjic-87	210	25	generally	generally	ADV
hjic-87	210	26	hard	hard	ADJ
hjic-87	210	27	to	to	PART
hjic-87	210	28	remove	remove	VERB
hjic-87	210	29	by	by	ADP
hjic-87	210	30	extraction	extraction	NOUN
hjic-87	210	31	.	.	PUNCT
hjic-87	211	1	previously	previously	ADV
hjic-87	211	2	,	,	PUNCT
hjic-87	211	3	gombotz	gombotz	PROPN
hjic-87	211	4	et	et	PROPN
hjic-87	211	5	al	al	PROPN
hjic-87	211	6	.	.	PROPN
hjic-87	211	7	published	publish	VERB
hjic-87	211	8	another	another	DET
hjic-87	211	9	process	process	NOUN
hjic-87	211	10	,	,	PUNCT
hjic-87	211	11	which	which	PRON
hjic-87	211	12	consists	consist	VERB
hjic-87	211	13	in	in	ADP
hjic-87	211	14	atomizing	atomize	VERB
hjic-87	211	15	the	the	DET
hjic-87	211	16	solution	solution	NOUN
hjic-87	211	17	or	or	CCONJ
hjic-87	211	18	suspension	suspension	NOUN
hjic-87	211	19	of	of	ADP
hjic-87	211	20	api	api	NOUN
hjic-87	211	21	into	into	ADP
hjic-87	211	22	a	a	DET
hjic-87	211	23	liquefied	liquefy	VERB
hjic-87	211	24	gas	gas	NOUN
hjic-87	211	25	and	and	CCONJ
hjic-87	211	26	lyophilizing	lyophilize	VERB
hjic-87	211	27	the	the	DET
hjic-87	211	28	frozen	frozen	ADJ
hjic-87	211	29	particles	particle	NOUN
hjic-87	211	30	[	[	X
hjic-87	211	31	81	81	NUM
hjic-87	211	32	]	]	PUNCT
hjic-87	211	33	.	.	PUNCT
hjic-87	212	1	their	their	PRON
hjic-87	212	2	method	method	NOUN
hjic-87	212	3	aimed	aim	VERB
hjic-87	212	4	to	to	PART
hjic-87	212	5	prepare	prepare	VERB
hjic-87	212	6	microspheres	microsphere	NOUN
hjic-87	212	7	of	of	ADP
hjic-87	212	8	apis	apis	NOUN
hjic-87	212	9	including	include	VERB
hjic-87	212	10	zinc	zinc	NOUN
hjic-87	212	11	insulin	insulin	NOUN
hjic-87	212	12	,	,	PUNCT
hjic-87	212	13	catalase	catalase	NOUN
hjic-87	212	14	,	,	PUNCT
hjic-87	212	15	heparin	heparin	NOUN
hjic-87	212	16	,	,	PUNCT
hjic-87	212	17	hemoglobin	hemoglobin	NOUN
hjic-87	212	18	,	,	PUNCT
hjic-87	212	19	dextran	dextran	NOUN
hjic-87	212	20	,	,	PUNCT
hjic-87	212	21	superoxide	superoxide	NOUN
hjic-87	212	22	dismutase	dismutase	NOUN
hjic-87	212	23	(	(	PUNCT
hjic-87	212	24	sod	sod	NOUN
hjic-87	212	25	)	)	PUNCT
hjic-87	212	26	,	,	PUNCT
hjic-87	212	27	horse	horse	NOUN
hjic-87	212	28	radish	radish	ADJ
hjic-87	212	29	peroxidase	peroxidase	NOUN
hjic-87	212	30	(	(	PUNCT
hjic-87	212	31	hrp	hrp	PROPN
hjic-87	212	32	)	)	PUNCT
hjic-87	212	33	,	,	PUNCT
hjic-87	212	34	bovin	bovin	NOUN
hjic-87	212	35	serum	serum	NOUN
hjic-87	212	36	albumin	albumin	PROPN
hjic-87	212	37	(	(	PUNCT
hjic-87	212	38	bsa	bsa	PROPN
hjic-87	212	39	)	)	PUNCT
hjic-87	212	40	,	,	PUNCT
hjic-87	212	41	glycine	glycine	NOUN
hjic-87	212	42	and	and	CCONJ
hjic-87	212	43	testosterone	testosterone	NOUN
hjic-87	212	44	.	.	PUNCT
hjic-87	213	1	particles	particle	NOUN
hjic-87	213	2	ranged	range	VERB
hjic-87	213	3	from	from	ADP
hjic-87	213	4	10	10	NUM
hjic-87	213	5	to	to	PART
hjic-87	213	6	90	90	NUM
hjic-87	213	7	µm	µm	NOUN
hjic-87	213	8	in	in	ADP
hjic-87	213	9	diameter	diameter	NOUN
hjic-87	213	10	and	and	CCONJ
hjic-87	213	11	kept	keep	VERB
hjic-87	213	12	70	70	NUM
hjic-87	213	13	–	–	SYM
hjic-87	213	14	95	95	NUM
hjic-87	213	15	%	%	NOUN
hjic-87	213	16	of	of	ADP
hjic-87	213	17	their	their	PRON
hjic-87	213	18	initial	initial	ADJ
hjic-87	213	19	biological	biological	ADJ
hjic-87	213	20	activity	activity	NOUN
hjic-87	213	21	.	.	PUNCT
hjic-87	214	1	to	to	PART
hjic-87	214	2	achieve	achieve	VERB
hjic-87	214	3	a	a	DET
hjic-87	214	4	mean	mean	ADJ
hjic-87	214	5	diameter	diameter	NOUN
hjic-87	214	6	smaller	small	ADJ
hjic-87	214	7	than	than	ADP
hjic-87	214	8	10	10	NUM
hjic-87	214	9	µm	µm	NOUN
hjic-87	214	10	–	–	PUNCT
hjic-87	214	11	which	which	PRON
hjic-87	214	12	is	be	AUX
hjic-87	214	13	desirable	desirable	ADJ
hjic-87	214	14	in	in	ADP
hjic-87	214	15	the	the	DET
hjic-87	214	16	case	case	NOUN
hjic-87	214	17	of	of	ADP
hjic-87	214	18	injectable	injectable	ADJ
hjic-87	214	19	polymeric	polymeric	ADJ
hjic-87	214	20	microspheres	microsphere	NOUN
hjic-87	214	21	of	of	ADP
hjic-87	214	22	controlled	control	VERB
hjic-87	214	23	drug	drug	NOUN
hjic-87	214	24	delivery	delivery	NOUN
hjic-87	214	25	system	system	NOUN
hjic-87	214	26	–	–	PUNCT
hjic-87	214	27	the	the	DET
hjic-87	214	28	lyophilized	lyophilized	ADJ
hjic-87	214	29	product	product	NOUN
hjic-87	214	30	was	be	AUX
hjic-87	214	31	suspended	suspend	VERB
hjic-87	214	32	in	in	ADP
hjic-87	214	33	a	a	DET
hjic-87	214	34	nonsolvent	nonsolvent	NOUN
hjic-87	214	35	and	and	CCONJ
hjic-87	214	36	exposed	expose	VERB
hjic-87	214	37	to	to	ADP
hjic-87	214	38	ultrasonic	ultrasonic	ADJ
hjic-87	214	39	energy	energy	NOUN
hjic-87	214	40	.	.	PUNCT
hjic-87	215	1	owing	owe	VERB
hjic-87	215	2	to	to	ADP
hjic-87	215	3	the	the	DET
hjic-87	215	4	porous	porous	ADJ
hjic-87	215	5	structure	structure	NOUN
hjic-87	215	6	and	and	CCONJ
hjic-87	215	7	the	the	DET
hjic-87	215	8	great	great	ADJ
hjic-87	215	9	specific	specific	ADJ
hjic-87	215	10	surface	surface	NOUN
hjic-87	215	11	area	area	NOUN
hjic-87	215	12	that	that	PRON
hjic-87	215	13	characterize	characterize	VERB
hjic-87	215	14	the	the	DET
hjic-87	215	15	lyophilized	lyophilized	ADJ
hjic-87	215	16	product	product	NOUN
hjic-87	215	17	,	,	PUNCT
hjic-87	215	18	particles	particle	NOUN
hjic-87	215	19	were	be	AUX
hjic-87	215	20	easy	easy	ADJ
hjic-87	215	21	to	to	PART
hjic-87	215	22	disintegrate	disintegrate	VERB
hjic-87	215	23	,	,	PUNCT
hjic-87	215	24	leading	lead	VERB
hjic-87	215	25	to	to	ADP
hjic-87	215	26	a	a	DET
hjic-87	215	27	mean	mean	ADJ
hjic-87	215	28	diameter	diameter	NOUN
hjic-87	215	29	between	between	ADP
hjic-87	215	30	0,1	0,1	NUM
hjic-87	215	31	and	and	CCONJ
hjic-87	215	32	10	10	NUM
hjic-87	215	33	µm	µm	NOUN
hjic-87	215	34	.	.	PUNCT
hjic-87	216	1	lyophilization	lyophilization	NOUN
hjic-87	216	2	is	be	AUX
hjic-87	216	3	a	a	DET
hjic-87	216	4	widespread	widespread	ADJ
hjic-87	216	5	process	process	NOUN
hjic-87	216	6	in	in	ADP
hjic-87	216	7	pharmaceutical	pharmaceutical	NOUN
hjic-87	216	8	and	and	CCONJ
hjic-87	216	9	food	food	NOUN
hjic-87	216	10	industry	industry	NOUN
hjic-87	216	11	but	but	CCONJ
hjic-87	216	12	rather	rather	ADV
hjic-87	216	13	expensive	expensive	ADJ
hjic-87	216	14	and	and	CCONJ
hjic-87	216	15	time	time	NOUN
hjic-87	216	16	-	-	PUNCT
hjic-87	216	17	consuming	consume	VERB
hjic-87	216	18	.	.	PUNCT
hjic-87	217	1	mumenthaler	mumenthaler	NOUN
hjic-87	217	2	and	and	CCONJ
hjic-87	217	3	oyler	oyler	NOUN
hjic-87	217	4	used	use	VERB
hjic-87	217	5	recirculated	recirculate	VERB
hjic-87	217	6	dry	dry	ADJ
hjic-87	217	7	gas	gas	NOUN
hjic-87	217	8	instead	instead	ADV
hjic-87	217	9	of	of	ADP
hjic-87	217	10	vacuum	vacuum	NOUN
hjic-87	217	11	to	to	PART
hjic-87	217	12	remove	remove	VERB
hjic-87	217	13	residual	residual	ADJ
hjic-87	217	14	solvent	solvent	NOUN
hjic-87	217	15	from	from	ADP
hjic-87	217	16	particles	particle	NOUN
hjic-87	217	17	previously	previously	ADV
hjic-87	217	18	sprayed	spray	VERB
hjic-87	217	19	into	into	ADP
hjic-87	217	20	cryogenic	cryogenic	ADJ
hjic-87	217	21	air	air	NOUN
hjic-87	217	22	[	[	X
hjic-87	217	23	82,83	82,83	NUM
hjic-87	217	24	]	]	PUNCT
hjic-87	217	25	(	(	PUNCT
hjic-87	217	26	see	see	VERB
hjic-87	217	27	fig	fig	NOUN
hjic-87	217	28	.	.	PUNCT
hjic-87	218	1	4	4	NUM
hjic-87	218	2	)	)	PUNCT
hjic-87	218	3	.	.	PUNCT
hjic-87	219	1	during	during	ADP
hjic-87	219	2	spray	spray	NOUN
hjic-87	219	3	-	-	PUNCT
hjic-87	219	4	freezing	freeze	VERB
hjic-87	219	5	cold	cold	ADJ
hjic-87	219	6	gas	gas	NOUN
hjic-87	219	7	is	be	AUX
hjic-87	219	8	supplied	supply	VERB
hjic-87	219	9	on	on	ADP
hjic-87	219	10	the	the	DET
hjic-87	219	11	top	top	NOUN
hjic-87	219	12	of	of	ADP
hjic-87	219	13	the	the	DET
hjic-87	219	14	vessel	vessel	NOUN
hjic-87	219	15	around	around	ADP
hjic-87	219	16	the	the	DET
hjic-87	219	17	spray	spray	NOUN
hjic-87	219	18	nozzle	nozzle	NOUN
hjic-87	219	19	.	.	PUNCT
hjic-87	220	1	when	when	SCONJ
hjic-87	220	2	spray	spray	NOUN
hjic-87	220	3	freezing	freezing	NOUN
hjic-87	220	4	is	be	AUX
hjic-87	220	5	over	over	ADV
hjic-87	220	6	,	,	PUNCT
hjic-87	220	7	frozen	frozen	ADJ
hjic-87	220	8	particles	particle	NOUN
hjic-87	220	9	are	be	AUX
hjic-87	220	10	fluidized	fluidize	VERB
hjic-87	220	11	by	by	ADP
hjic-87	220	12	passing	pass	VERB
hjic-87	220	13	the	the	DET
hjic-87	220	14	gas	gas	NOUN
hjic-87	220	15	through	through	ADP
hjic-87	220	16	the	the	DET
hjic-87	220	17	bed	bed	NOUN
hjic-87	220	18	.	.	PUNCT
hjic-87	221	1	solvent	solvent	ADJ
hjic-87	221	2	vapors	vapor	NOUN
hjic-87	221	3	are	be	AUX
hjic-87	221	4	continuously	continuously	ADV
hjic-87	221	5	condensed	condense	VERB
hjic-87	221	6	in	in	ADP
hjic-87	221	7	a	a	DET
hjic-87	221	8	heat	heat	NOUN
hjic-87	221	9	exchanger	exchanger	NOUN
hjic-87	221	10	.	.	PUNCT
hjic-87	222	1	the	the	DET
hjic-87	222	2	temperature	temperature	NOUN
hjic-87	222	3	of	of	ADP
hjic-87	222	4	dry	dry	ADJ
hjic-87	222	5	gas	gas	NOUN
hjic-87	222	6	must	must	AUX
hjic-87	222	7	be	be	AUX
hjic-87	222	8	carefully	carefully	ADV
hjic-87	222	9	controlled	control	VERB
hjic-87	222	10	to	to	PART
hjic-87	222	11	supply	supply	VERB
hjic-87	222	12	the	the	DET
hjic-87	222	13	heat	heat	NOUN
hjic-87	222	14	of	of	ADP
hjic-87	222	15	sublimation	sublimation	NOUN
hjic-87	222	16	without	without	ADP
hjic-87	222	17	melting	melt	VERB
hjic-87	222	18	the	the	DET
hjic-87	222	19	frozen	frozen	ADJ
hjic-87	222	20	droplets	droplet	NOUN
hjic-87	222	21	.	.	PUNCT
hjic-87	223	1	fig	fig	NOUN
hjic-87	223	2	.	.	PUNCT
hjic-87	224	1	4	4	NUM
hjic-87	224	2	schematic	schematic	ADJ
hjic-87	224	3	diagram	diagram	NOUN
hjic-87	224	4	of	of	ADP
hjic-87	224	5	the	the	DET
hjic-87	224	6	apparatus	apparatus	NOUN
hjic-87	224	7	invented	invent	VERB
hjic-87	224	8	by	by	ADP
hjic-87	224	9	oyler	oyler	NOUN
hjic-87	224	10	.	.	PUNCT
hjic-87	225	1	1	1	X
hjic-87	225	2	.	.	X
hjic-87	225	3	freezing	freeze	VERB
hjic-87	225	4	and	and	CCONJ
hjic-87	225	5	drying	dry	VERB
hjic-87	225	6	vessel	vessel	NOUN
hjic-87	225	7	;	;	PUNCT
hjic-87	225	8	2.cyclone	2.cyclone	NUM
hjic-87	225	9	;	;	PUNCT
hjic-87	225	10	3	3	X
hjic-87	225	11	.	.	X
hjic-87	225	12	turbine	turbine	NOUN
hjic-87	225	13	;	;	PUNCT
hjic-87	225	14	4.heat	4.heat	NUM
hjic-87	225	15	exchanger	exchanger	NOUN
hjic-87	225	16	;	;	PUNCT
hjic-87	225	17	5.three	5.three	NUM
hjic-87	225	18	-	-	PUNCT
hjic-87	225	19	way	way	NOUN
hjic-87	225	20	valve	valve	NOUN
hjic-87	225	21	;	;	PUNCT
hjic-87	225	22	6	6	NUM
hjic-87	225	23	.	.	X
hjic-87	225	24	nozzle	nozzle	NOUN
hjic-87	225	25	more	more	ADV
hjic-87	225	26	intense	intense	ADJ
hjic-87	225	27	atomization	atomization	NOUN
hjic-87	225	28	can	can	AUX
hjic-87	225	29	be	be	AUX
hjic-87	225	30	achieved	achieve	VERB
hjic-87	225	31	by	by	ADP
hjic-87	225	32	submerging	submerge	VERB
hjic-87	225	33	the	the	DET
hjic-87	225	34	nozzle	nozzle	NOUN
hjic-87	225	35	into	into	ADP
hjic-87	225	36	the	the	DET
hjic-87	225	37	cryogenic	cryogenic	ADJ
hjic-87	225	38	substance	substance	NOUN
hjic-87	225	39	.	.	PUNCT
hjic-87	226	1	due	due	ADP
hjic-87	226	2	to	to	ADP
hjic-87	226	3	the	the	DET
hjic-87	226	4	liquid	liquid	NOUN
hjic-87	226	5	-	-	PUNCT
hjic-87	226	6	liquid	liquid	ADJ
hjic-87	226	7	collision	collision	NOUN
hjic-87	226	8	,	,	PUNCT
hjic-87	226	9	atomization	atomization	NOUN
hjic-87	226	10	beneath	beneath	ADP
hjic-87	226	11	the	the	DET
hjic-87	226	12	surface	surface	NOUN
hjic-87	226	13	of	of	ADP
hjic-87	226	14	cryogen	cryogen	NOUN
hjic-87	226	15	results	result	NOUN
hjic-87	226	16	in	in	ADP
hjic-87	226	17	smaller	small	ADJ
hjic-87	226	18	droplets	droplet	NOUN
hjic-87	226	19	which	which	PRON
hjic-87	226	20	freeze	freeze	VERB
hjic-87	226	21	much	much	ADV
hjic-87	226	22	faster	fast	ADV
hjic-87	226	23	.	.	PUNCT
hjic-87	227	1	in	in	ADP
hjic-87	227	2	1969	1969	NUM
hjic-87	227	3	,	,	PUNCT
hjic-87	227	4	harold	harold	PROPN
hjic-87	227	5	a	a	PROPN
hjic-87	227	6	sauer	sauer	PROPN
hjic-87	227	7	patented	patent	VERB
hjic-87	227	8	the	the	DET
hjic-87	227	9	first	first	ADJ
hjic-87	227	10	method	method	NOUN
hjic-87	227	11	using	use	VERB
hjic-87	227	12	submerged	submerge	VERB
hjic-87	227	13	atomization	atomization	NOUN
hjic-87	227	14	device	device	NOUN
hjic-87	227	15	[	[	X
hjic-87	227	16	84	84	NUM
hjic-87	227	17	]	]	PUNCT
hjic-87	227	18	(	(	PUNCT
hjic-87	227	19	see	see	VERB
hjic-87	227	20	fig	fig	NOUN
hjic-87	227	21	.	.	PUNCT
hjic-87	228	1	5	5	NUM
hjic-87	228	2	)	)	PUNCT
hjic-87	228	3	.	.	PUNCT
hjic-87	229	1	solution	solution	NOUN
hjic-87	229	2	was	be	AUX
hjic-87	229	3	injected	inject	VERB
hjic-87	229	4	in	in	ADP
hjic-87	229	5	liquid	liquid	ADJ
hjic-87	229	6	refrigerant	refrigerant	NOUN
hjic-87	229	7	through	through	ADP
hjic-87	229	8	a	a	DET
hjic-87	229	9	heated	heated	ADJ
hjic-87	229	10	nozzle	nozzle	NOUN
hjic-87	229	11	at	at	ADP
hjic-87	229	12	the	the	DET
hjic-87	229	13	bottom	bottom	NOUN
hjic-87	229	14	of	of	ADP
hjic-87	229	15	the	the	DET
hjic-87	229	16	vessel	vessel	NOUN
hjic-87	229	17	.	.	PUNCT
hjic-87	230	1	at	at	ADP
hjic-87	230	2	the	the	DET
hjic-87	230	3	end	end	NOUN
hjic-87	230	4	of	of	ADP
hjic-87	230	5	the	the	DET
hjic-87	230	6	atomization	atomization	NOUN
hjic-87	230	7	process	process	NOUN
hjic-87	230	8	,	,	PUNCT
hjic-87	230	9	frozen	frozen	ADJ
hjic-87	230	10	droplets	droplet	NOUN
hjic-87	230	11	floating	float	VERB
hjic-87	230	12	on	on	ADP
hjic-87	230	13	the	the	DET
hjic-87	230	14	surface	surface	NOUN
hjic-87	230	15	were	be	AUX
hjic-87	230	16	collected	collect	VERB
hjic-87	230	17	in	in	ADP
hjic-87	230	18	a	a	DET
hjic-87	230	19	spherical	spherical	ADJ
hjic-87	230	20	screen	screen	NOUN
hjic-87	230	21	and	and	CCONJ
hjic-87	230	22	dried	dry	VERB
hjic-87	230	23	in	in	ADP
hjic-87	230	24	cold	cold	ADJ
hjic-87	230	25	air	air	NOUN
hjic-87	230	26	or	or	CCONJ
hjic-87	230	27	nitrogen	nitrogen	NOUN
hjic-87	230	28	gas	gas	NOUN
hjic-87	230	29	.	.	PUNCT
hjic-87	231	1	residual	residual	ADJ
hjic-87	231	2	moisture	moisture	NOUN
hjic-87	231	3	was	be	AUX
hjic-87	231	4	removed	remove	VERB
hjic-87	231	5	by	by	ADP
hjic-87	231	6	successively	successively	ADV
hjic-87	231	7	reducing	reduce	VERB
hjic-87	231	8	the	the	DET
hjic-87	231	9	pressure	pressure	NOUN
hjic-87	231	10	in	in	ADP
hjic-87	231	11	the	the	DET
hjic-87	231	12	chamber	chamber	NOUN
hjic-87	231	13	.	.	PUNCT
hjic-87	232	1	the	the	DET
hjic-87	232	2	method	method	NOUN
hjic-87	232	3	developed	develop	VERB
hjic-87	232	4	by	by	ADP
hjic-87	232	5	dunn	dunn	PROPN
hjic-87	232	6	involves	involve	VERB
hjic-87	232	7	two	two	NUM
hjic-87	232	8	immiscible	immiscible	ADJ
hjic-87	232	9	halocarbon	halocarbon	NOUN
hjic-87	232	10	refrigerants	refrigerant	NOUN
hjic-87	232	11	.	.	PUNCT
hjic-87	233	1	the	the	DET
hjic-87	233	2	boiling	boiling	NOUN
hjic-87	233	3	point	point	NOUN
hjic-87	233	4	of	of	ADP
hjic-87	233	5	the	the	DET
hjic-87	233	6	denser	dense	ADJ
hjic-87	233	7	refrigerant	refrigerant	NOUN
hjic-87	233	8	must	must	AUX
hjic-87	233	9	be	be	AUX
hjic-87	233	10	slightly	slightly	ADV
hjic-87	233	11	above	above	ADP
hjic-87	233	12	the	the	DET
hjic-87	233	13	melting	melting	NOUN
hjic-87	233	14	point	point	NOUN
hjic-87	233	15	of	of	ADP
hjic-87	233	16	the	the	DET
hjic-87	233	17	solvent	solvent	NOUN
hjic-87	233	18	while	while	SCONJ
hjic-87	233	19	that	that	PRON
hjic-87	233	20	of	of	ADP
hjic-87	233	21	the	the	DET
hjic-87	233	22	lighter	light	ADJ
hjic-87	233	23	one	one	NOUN
hjic-87	233	24	is	be	AUX
hjic-87	233	25	lower	low	ADJ
hjic-87	233	26	.	.	PUNCT
hjic-87	234	1	solution	solution	NOUN
hjic-87	234	2	is	be	AUX
hjic-87	234	3	dispersed	disperse	VERB
hjic-87	234	4	through	through	ADP
hjic-87	234	5	a	a	DET
hjic-87	234	6	heated	heated	ADJ
hjic-87	234	7	nozzle	nozzle	NOUN
hjic-87	234	8	in	in	ADP
hjic-87	234	9	the	the	DET
hjic-87	234	10	denser	dense	ADJ
hjic-87	234	11	phase	phase	NOUN
hjic-87	234	12	from	from	ADP
hjic-87	234	13	51	51	NUM
hjic-87	234	14	fig	fig	NOUN
hjic-87	234	15	.	.	PUNCT
hjic-87	235	1	5	5	NUM
hjic-87	235	2	schematic	schematic	ADJ
hjic-87	235	3	diagram	diagram	NOUN
hjic-87	235	4	of	of	ADP
hjic-87	235	5	the	the	DET
hjic-87	235	6	apparatus	apparatus	NOUN
hjic-87	235	7	invented	invent	VERB
hjic-87	235	8	by	by	ADP
hjic-87	235	9	harold	harold	PROPN
hjic-87	235	10	a	a	DET
hjic-87	235	11	sauer	sauer	NOUN
hjic-87	235	12	.	.	PUNCT
hjic-87	236	1	1	1	X
hjic-87	236	2	.	.	X
hjic-87	236	3	freezing	freeze	VERB
hjic-87	236	4	and	and	CCONJ
hjic-87	236	5	drying	dry	VERB
hjic-87	236	6	vessel	vessel	NOUN
hjic-87	236	7	;	;	PUNCT
hjic-87	236	8	2	2	X
hjic-87	236	9	.	.	X
hjic-87	236	10	nozzle	nozzle	NOUN
hjic-87	236	11	;	;	PUNCT
hjic-87	236	12	3	3	X
hjic-87	236	13	.	.	X
hjic-87	236	14	screen	screen	NOUN
hjic-87	236	15	hemisphere	hemisphere	ADV
hjic-87	236	16	;	;	PUNCT
hjic-87	236	17	4	4	NUM
hjic-87	236	18	.mixer	.mixer	NOUN
hjic-87	236	19	paddle	paddle	NOUN
hjic-87	236	20	;	;	PUNCT
hjic-87	236	21	which	which	DET
hjic-87	236	22	rising	rise	VERB
hjic-87	236	23	solution	solution	NOUN
hjic-87	236	24	droplets	droplet	NOUN
hjic-87	236	25	step	step	VERB
hjic-87	236	26	in	in	ADP
hjic-87	236	27	the	the	DET
hjic-87	236	28	lighter	light	ADJ
hjic-87	236	29	refrigerant	refrigerant	NOUN
hjic-87	236	30	and	and	CCONJ
hjic-87	236	31	solidify	solidify	VERB
hjic-87	236	32	[	[	X
hjic-87	236	33	85	85	NUM
hjic-87	236	34	]	]	PUNCT
hjic-87	236	35	(	(	PUNCT
hjic-87	236	36	see	see	VERB
hjic-87	236	37	fig	fig	NOUN
hjic-87	236	38	.	.	PUNCT
hjic-87	237	1	6	6	NUM
hjic-87	237	2	)	)	PUNCT
hjic-87	237	3	.	.	PUNCT
hjic-87	238	1	the	the	DET
hjic-87	238	2	frozen	frozen	ADJ
hjic-87	238	3	particles	particle	NOUN
hjic-87	238	4	floating	float	VERB
hjic-87	238	5	on	on	ADP
hjic-87	238	6	the	the	DET
hjic-87	238	7	surface	surface	NOUN
hjic-87	238	8	of	of	ADP
hjic-87	238	9	the	the	DET
hjic-87	238	10	upper	upper	ADJ
hjic-87	238	11	refrigerant	refrigerant	NOUN
hjic-87	238	12	are	be	AUX
hjic-87	238	13	collected	collect	VERB
hjic-87	238	14	and	and	CCONJ
hjic-87	238	15	lyophilized	lyophilize	VERB
hjic-87	238	16	.	.	PUNCT
hjic-87	239	1	authors	author	NOUN
hjic-87	239	2	described	describe	VERB
hjic-87	239	3	the	the	DET
hjic-87	239	4	precipitation	precipitation	NOUN
hjic-87	239	5	of	of	ADP
hjic-87	239	6	aluminum	aluminum	NOUN
hjic-87	239	7	sulfate	sulfate	NOUN
hjic-87	239	8	in	in	ADP
hjic-87	239	9	various	various	ADJ
hjic-87	239	10	freon	freon	NOUN
hjic-87	239	11	–	–	PUNCT
hjic-87	239	12	based	base	VERB
hjic-87	239	13	cryogenic	cryogenic	NOUN
hjic-87	239	14	systems	system	NOUN
hjic-87	239	15	.	.	PUNCT
hjic-87	240	1	fig	fig	NOUN
hjic-87	240	2	.	.	PUNCT
hjic-87	241	1	6	6	NUM
hjic-87	241	2	schematic	schematic	ADJ
hjic-87	241	3	diagram	diagram	NOUN
hjic-87	241	4	of	of	ADP
hjic-87	241	5	the	the	DET
hjic-87	241	6	apparatus	apparatus	NOUN
hjic-87	241	7	invented	invent	VERB
hjic-87	241	8	by	by	ADP
hjic-87	241	9	dunn	dunn	PROPN
hjic-87	241	10	et	et	PROPN
hjic-87	241	11	al	al	PROPN
hjic-87	241	12	.	.	PROPN
hjic-87	241	13	1	1	NUM
hjic-87	241	14	.	.	X
hjic-87	242	1	denser	dense	ADJ
hjic-87	242	2	refrigerant	refrigerant	NOUN
hjic-87	242	3	(	(	PUNCT
hjic-87	242	4	injection	injection	NOUN
hjic-87	242	5	zone	zone	NOUN
hjic-87	242	6	)	)	PUNCT
hjic-87	242	7	;	;	PUNCT
hjic-87	242	8	2	2	X
hjic-87	242	9	.	.	X
hjic-87	242	10	lighter	light	ADJ
hjic-87	242	11	refrigerant	refrigerant	NOUN
hjic-87	242	12	(	(	PUNCT
hjic-87	242	13	freezing	freezing	NOUN
hjic-87	242	14	zone	zone	NOUN
hjic-87	242	15	)	)	PUNCT
hjic-87	242	16	;	;	PUNCT
hjic-87	242	17	3	3	X
hjic-87	242	18	.	.	X
hjic-87	242	19	atomization	atomization	NOUN
hjic-87	242	20	device	device	NOUN
hjic-87	242	21	;	;	PUNCT
hjic-87	242	22	4	4	NUM
hjic-87	242	23	heating	heating	NOUN
hjic-87	242	24	coil	coil	NOUN
hjic-87	242	25	;	;	PUNCT
hjic-87	242	26	5	5	X
hjic-87	242	27	.	.	X
hjic-87	242	28	cooling	cool	VERB
hjic-87	242	29	coil	coil	NOUN
hjic-87	242	30	recently	recently	ADV
hjic-87	242	31	,	,	PUNCT
hjic-87	242	32	williams	williams	PROPN
hjic-87	242	33	et	et	PROPN
hjic-87	242	34	al	al	PROPN
hjic-87	242	35	.	.	PROPN
hjic-87	242	36	invented	invent	VERB
hjic-87	242	37	a	a	DET
hjic-87	242	38	method	method	NOUN
hjic-87	242	39	called	call	VERB
hjic-87	242	40	spray	spray	NOUN
hjic-87	242	41	-	-	PUNCT
hjic-87	242	42	freezing	freezing	NOUN
hjic-87	242	43	into	into	ADP
hjic-87	242	44	liquid	liquid	NOUN
hjic-87	242	45	(	(	PUNCT
hjic-87	242	46	sfl	sfl	PROPN
hjic-87	242	47	)	)	PUNCT
hjic-87	242	48	which	which	PRON
hjic-87	242	49	,	,	PUNCT
hjic-87	242	50	due	due	ADP
hjic-87	242	51	to	to	ADP
hjic-87	242	52	an	an	DET
hjic-87	242	53	insulating	insulate	VERB
hjic-87	242	54	nozzle	nozzle	NOUN
hjic-87	242	55	,	,	PUNCT
hjic-87	242	56	allows	allow	VERB
hjic-87	242	57	injection	injection	NOUN
hjic-87	242	58	into	into	ADP
hjic-87	242	59	extremely	extremely	ADV
hjic-87	242	60	cold	cold	ADJ
hjic-87	242	61	liquids	liquid	NOUN
hjic-87	242	62	–	–	PUNCT
hjic-87	242	63	i.e.	i.e.	X
hjic-87	242	64	liquefied	liquefy	VERB
hjic-87	242	65	gases	gas	NOUN
hjic-87	242	66	–	–	PUNCT
hjic-87	242	67	without	without	ADP
hjic-87	242	68	any	any	DET
hjic-87	242	69	nozzle	nozzle	NOUN
hjic-87	242	70	blockage	blockage	NOUN
hjic-87	242	71	[	[	X
hjic-87	242	72	86	86	NUM
hjic-87	242	73	]	]	PUNCT
hjic-87	242	74	(	(	PUNCT
hjic-87	242	75	see	see	VERB
hjic-87	242	76	fig	fig	NOUN
hjic-87	242	77	.	.	PUNCT
hjic-87	243	1	7	7	NUM
hjic-87	243	2	)	)	PUNCT
hjic-87	243	3	.	.	PUNCT
hjic-87	244	1	the	the	DET
hjic-87	244	2	authors	author	NOUN
hjic-87	244	3	recommended	recommend	VERB
hjic-87	244	4	nozzles	nozzle	NOUN
hjic-87	244	5	made	make	VERB
hjic-87	244	6	of	of	ADP
hjic-87	244	7	molded	mold	VERB
hjic-87	244	8	tip	tip	NOUN
hjic-87	244	9	(	(	PUNCT
hjic-87	244	10	polyetheretherketone	polyetheretherketone	NOUN
hjic-87	244	11	,	,	PUNCT
hjic-87	244	12	polyether	polyether	X
hjic-87	244	13	block	block	NOUN
hjic-87	244	14	amide	amide	NOUN
hjic-87	244	15	or	or	CCONJ
hjic-87	244	16	polyurethane	polyurethane	NOUN
hjic-87	244	17	elastomers	elastomer	NOUN
hjic-87	244	18	)	)	PUNCT
hjic-87	244	19	.	.	PUNCT
hjic-87	245	1	fig	fig	NOUN
hjic-87	245	2	.	.	PUNCT
hjic-87	246	1	7	7	NUM
hjic-87	246	2	schematic	schematic	ADJ
hjic-87	246	3	diagram	diagram	NOUN
hjic-87	246	4	of	of	ADP
hjic-87	246	5	the	the	DET
hjic-87	246	6	apparatus	apparatus	NOUN
hjic-87	246	7	invented	invent	VERB
hjic-87	246	8	by	by	ADP
hjic-87	246	9	williams	williams	PROPN
hjic-87	246	10	et	et	PROPN
hjic-87	246	11	al	al	PROPN
hjic-87	246	12	.	.	PROPN
hjic-87	246	13	1	1	NUM
hjic-87	246	14	.	.	PUNCT
hjic-87	246	15	liquified	liquified	ADJ
hjic-87	246	16	gas	gas	NOUN
hjic-87	246	17	;	;	PUNCT
hjic-87	246	18	2	2	X
hjic-87	246	19	.	.	X
hjic-87	246	20	insulating	insulate	VERB
hjic-87	246	21	nozzle	nozzle	NOUN
hjic-87	246	22	;	;	PUNCT
hjic-87	246	23	3	3	X
hjic-87	246	24	.	.	X
hjic-87	246	25	propeller	propeller	NOUN
hjic-87	246	26	stirrer	stirrer	ADJ
hjic-87	246	27	physical	physical	ADJ
hjic-87	246	28	properties	property	NOUN
hjic-87	246	29	of	of	ADP
hjic-87	246	30	the	the	DET
hjic-87	246	31	lyophilized	lyophilized	ADJ
hjic-87	246	32	solid	solid	ADJ
hjic-87	246	33	particles	particle	NOUN
hjic-87	246	34	were	be	AUX
hjic-87	246	35	found	find	VERB
hjic-87	246	36	advantageous	advantageous	ADJ
hjic-87	246	37	in	in	ADP
hjic-87	246	38	many	many	ADJ
hjic-87	246	39	respects	respect	NOUN
hjic-87	246	40	foremost	foremost	ADV
hjic-87	246	41	in	in	ADP
hjic-87	246	42	the	the	DET
hjic-87	246	43	case	case	NOUN
hjic-87	246	44	of	of	ADP
hjic-87	246	45	poorly	poorly	ADV
hjic-87	246	46	water	water	NOUN
hjic-87	246	47	soluble	soluble	ADJ
hjic-87	246	48	apis	apis	NOUN
hjic-87	246	49	:	:	PUNCT
hjic-87	246	50	•	•	NUM
hjic-87	246	51	mean	mean	NOUN
hjic-87	246	52	particle	particle	NOUN
hjic-87	246	53	size	size	NOUN
hjic-87	246	54	:	:	PUNCT
hjic-87	246	55	0,68	0,68	X
hjic-87	246	56	–	–	PUNCT
hjic-87	246	57	16	16	NUM
hjic-87	246	58	µm	µm	SYM
hjic-87	246	59	•	•	NOUN
hjic-87	246	60	amorphous	amorphous	ADJ
hjic-87	246	61	solid	solid	ADJ
hjic-87	246	62	dispersion	dispersion	NOUN
hjic-87	246	63	•	•	ADP
hjic-87	246	64	great	great	ADJ
hjic-87	246	65	specific	specific	ADJ
hjic-87	246	66	surface	surface	NOUN
hjic-87	246	67	area	area	NOUN
hjic-87	246	68	:	:	PUNCT
hjic-87	246	69	3	3	NUM
hjic-87	246	70	-	-	SYM
hjic-87	246	71	117	117	NUM
hjic-87	246	72	m2	m2	PROPN
hjic-87	246	73	/	/	SYM
hjic-87	246	74	g	g	PROPN
hjic-87	246	75	•	•	ADV
hjic-87	246	76	porous	porous	ADJ
hjic-87	246	77	structure	structure	NOUN
hjic-87	246	78	•	•	ADP
hjic-87	246	79	enhanced	enhance	VERB
hjic-87	246	80	rate	rate	NOUN
hjic-87	246	81	of	of	ADP
hjic-87	246	82	dissolution	dissolution	NOUN
hjic-87	246	83	•	•	NUM
hjic-87	246	84	improved	improve	VERB
hjic-87	246	85	wettability	wettability	NOUN
hjic-87	246	86	•	•	ADP
hjic-87	246	87	low	low	ADJ
hjic-87	246	88	residual	residual	ADJ
hjic-87	246	89	solvent	solvent	NOUN
hjic-87	246	90	content	content	NOUN
hjic-87	246	91	.	.	PUNCT
hjic-87	247	1	52	52	NUM
hjic-87	247	2	table	table	NOUN
hjic-87	247	3	6	6	NUM
hjic-87	247	4	summary	summary	NOUN
hjic-87	247	5	of	of	ADP
hjic-87	247	6	drug	drug	NOUN
hjic-87	247	7	-	-	PUNCT
hjic-87	247	8	carrier	carrier	NOUN
hjic-87	247	9	systems	system	NOUN
hjic-87	247	10	precipitated	precipitate	VERB
hjic-87	247	11	by	by	ADP
hjic-87	247	12	cryogenic	cryogenic	NOUN
hjic-87	247	13	formulation	formulation	NOUN
hjic-87	247	14	techniques	technique	NOUN
hjic-87	247	15	.	.	PUNCT
hjic-87	248	1	drug	drug	NOUN
hjic-87	248	2	excipient	excipient	PROPN
hjic-87	248	3	solvent	solvent	NOUN
hjic-87	248	4	observation	observation	NOUN
hjic-87	248	5	references	reference	NOUN
hjic-87	248	6	nad	nad	PROPN
hjic-87	248	7	,	,	PUNCT
hjic-87	248	8	nadh	nadh	NOUN
hjic-87	248	9	,	,	PUNCT
hjic-87	248	10	luciferase	luciferase	ADJ
hjic-87	248	11	,	,	PUNCT
hjic-87	248	12	luciferin	luciferin	NOUN
hjic-87	248	13	,	,	PUNCT
hjic-87	248	14	hexokinase	hexokinase	NOUN
hjic-87	248	15	,	,	PUNCT
hjic-87	248	16	g-6	g-6	NOUN
hjic-87	248	17	-	-	PUNCT
hjic-87	248	18	pdh	pdh	PROPN
hjic-87	248	19	,	,	PUNCT
hjic-87	248	20	ldh	ldh	PROPN
hjic-87	248	21	,	,	PUNCT
hjic-87	248	22	pyruvate	pyruvate	NOUN
hjic-87	248	23	kinase	kinase	NOUN
hjic-87	248	24	,	,	PUNCT
hjic-87	248	25	bovine	bovine	NOUN
hjic-87	248	26	albumin	albumin	NOUN
hjic-87	248	27	,	,	PUNCT
hjic-87	248	28	mops	mop	NOUN
hjic-87	248	29	,	,	PUNCT
hjic-87	248	30	dip	dip	NOUN
hjic-87	248	31	mannitol	mannitol	NOUN
hjic-87	248	32	,	,	PUNCT
hjic-87	248	33	maltose	maltose	NOUN
hjic-87	248	34	,	,	PUNCT
hjic-87	248	35	lactose	lactose	NOUN
hjic-87	248	36	,	,	PUNCT
hjic-87	248	37	inositol	inositol	NOUN
hjic-87	248	38	,	,	PUNCT
hjic-87	248	39	peg	peg	NOUN
hjic-87	248	40	water	water	NOUN
hjic-87	248	41	(	(	PUNCT
hjic-87	248	42	kcl	kcl	NOUN
hjic-87	248	43	,	,	PUNCT
hjic-87	248	44	nahco3	nahco3	NOUN
hjic-87	248	45	)	)	PUNCT
hjic-87	248	46	embedded	embed	VERB
hjic-87	248	47	substrates	substrate	NOUN
hjic-87	248	48	with	with	ADP
hjic-87	248	49	high	high	ADJ
hjic-87	248	50	biological	biological	ADJ
hjic-87	248	51	activities	activity	NOUN
hjic-87	248	52	[	[	X
hjic-87	248	53	74	74	NUM
hjic-87	248	54	]	]	PUNCT
hjic-87	248	55	blood	blood	NOUN
hjic-87	248	56	serum	serum	NOUN
hjic-87	248	57	citric	citric	ADJ
hjic-87	248	58	acid	acid	NOUN
hjic-87	248	59	maltase	maltase	NOUN
hjic-87	248	60	enzyme	enzyme	NOUN
hjic-87	248	61	inositol	inositol	NOUN
hjic-87	248	62	,	,	PUNCT
hjic-87	248	63	mannitol	mannitol	NOUN
hjic-87	248	64	testosteron	testosteron	PROPN
hjic-87	248	65	sodium	sodium	PROPN
hjic-87	248	66	monoglutamate	monoglutamate	ADJ
hjic-87	248	67	vitamin	vitamin	NOUN
hjic-87	248	68	c	c	NOUN
hjic-87	248	69	inositol	inositol	NOUN
hjic-87	248	70	water	water	NOUN
hjic-87	248	71	cholesterol	cholesterol	NOUN
hjic-87	248	72	sds	sds	PROPN
hjic-87	248	73	water	water	NOUN
hjic-87	248	74	/	/	SYM
hjic-87	248	75	ethanol	ethanol	NOUN
hjic-87	248	76	embedded	embed	VERB
hjic-87	248	77	substrates	substrate	NOUN
hjic-87	248	78	with	with	ADP
hjic-87	248	79	high	high	ADJ
hjic-87	248	80	biological	biological	ADJ
hjic-87	248	81	activities	activity	NOUN
hjic-87	248	82	[	[	X
hjic-87	248	83	75,76	75,76	X
hjic-87	248	84	]	]	X
hjic-87	248	85	sod	sod	NOUN
hjic-87	248	86	,	,	PUNCT
hjic-87	248	87	hrp	hrp	PROPN
hjic-87	248	88	,	,	PUNCT
hjic-87	248	89	mitomycin	mitomycin	NOUN
hjic-87	248	90	c	c	NOUN
hjic-87	248	91	,	,	PUNCT
hjic-87	248	92	etoposide	etoposide	NOUN
hjic-87	248	93	,	,	PUNCT
hjic-87	248	94	hemoglobin	hemoglobin	NOUN
hjic-87	248	95	pla	pla	PROPN
hjic-87	248	96	plga	plga	VERB
hjic-87	248	97	dcm	dcm	PROPN
hjic-87	248	98	microspheres	microsphere	VERB
hjic-87	248	99	mps	mps	PROPN
hjic-87	248	100	b	b	NOUN
hjic-87	248	101	=	=	SYM
hjic-87	248	102	30	30	NUM
hjic-87	248	103	50	50	NUM
hjic-87	248	104	[	[	X
hjic-87	248	105	80	80	NUM
hjic-87	249	1	]	]	PUNCT
hjic-87	249	2	carbamazepine	carbamazepine	NOUN
hjic-87	249	3	sds	sds	PROPN
hjic-87	249	4	danazol	danazol	ADJ
hjic-87	249	5	pva	pva	NOUN
hjic-87	249	6	(	(	PUNCT
hjic-87	249	7	22000	22000	NUM
hjic-87	249	8	)	)	PUNCT
hjic-87	249	9	poloxamer	poloxamer	NOUN
hjic-87	249	10	407	407	NUM
hjic-87	249	11	pvp	pvp	PROPN
hjic-87	249	12	k15	k15	PROPN
hjic-87	249	13	water	water	NOUN
hjic-87	249	14	/	/	SYM
hjic-87	249	15	thf	thf	NOUN
hjic-87	249	16	insulin	insulin	NOUN
hjic-87	249	17	tyloxapol	tyloxapol	NOUN
hjic-87	249	18	lactose	lactose	VERB
hjic-87	249	19	trehalose	trehalose	DET
hjic-87	249	20	water	water	NOUN
hjic-87	249	21	solid	solid	ADJ
hjic-87	249	22	solution	solution	NOUN
hjic-87	249	23	mps	mp	NOUN
hjic-87	250	1	=	=	SYM
hjic-87	250	2	5,06	5,06	NUM
hjic-87	250	3	7,11	7,11	NOUN
hjic-87	250	4	ssa	ssa	NOUN
hjic-87	250	5	c	c	NOUN
hjic-87	250	6	=	=	SYM
hjic-87	250	7	12,81	12,81	NUM
hjic-87	250	8	44,44	44,44	X
hjic-87	251	1	[	[	X
hjic-87	251	2	86,87,90	86,87,90	NUM
hjic-87	251	3	]	]	PUNCT
hjic-87	251	4	danazol	danazol	ADJ
hjic-87	251	5	hp	hp	PROPN
hjic-87	251	6	-	-	PUNCT
hjic-87	251	7	β	β	NOUN
hjic-87	251	8	-	-	ADJ
hjic-87	251	9	cd	cd	ADJ
hjic-87	251	10	water	water	NOUN
hjic-87	251	11	/	/	SYM
hjic-87	251	12	thf	thf	NOUN
hjic-87	251	13	solid	solid	ADJ
hjic-87	251	14	solution	solution	NOUN
hjic-87	251	15	mps	mp	NOUN
hjic-87	251	16	=	=	SYM
hjic-87	251	17	7	7	NUM
hjic-87	251	18	;	;	PUNCT
hjic-87	251	19	ssa	ssa	NOUN
hjic-87	251	20	=	=	NOUN
hjic-87	251	21	113,5	113,5	NUM
hjic-87	252	1	[	[	X
hjic-87	252	2	86,88	86,88	X
hjic-87	252	3	]	]	PUNCT
hjic-87	252	4	danazol	danazol	ADJ
hjic-87	252	5	pva	pva	NOUN
hjic-87	252	6	(	(	PUNCT
hjic-87	252	7	22000	22000	NUM
hjic-87	252	8	)	)	PUNCT
hjic-87	252	9	poloxamer	poloxamer	NOUN
hjic-87	252	10	407	407	NUM
hjic-87	252	11	pvp	pvp	PROPN
hjic-87	252	12	k15	k15	PROPN
hjic-87	252	13	water	water	NOUN
hjic-87	252	14	/	/	SYM
hjic-87	252	15	thf	thf	NOUN
hjic-87	252	16	water	water	NOUN
hjic-87	252	17	/	/	SYM
hjic-87	252	18	ethyl	ethyl	PROPN
hjic-87	252	19	acetatea	acetatea	NOUN
hjic-87	252	20	water	water	PROPN
hjic-87	252	21	/	/	SYM
hjic-87	252	22	dcma	dcma	X
hjic-87	252	23	solid	solid	ADJ
hjic-87	252	24	solution	solution	NOUN
hjic-87	252	25	mps	mp	NOUN
hjic-87	252	26	=	=	SYM
hjic-87	253	1	6,52	6,52	NUM
hjic-87	253	2	16,75	16,75	NOUN
hjic-87	253	3	ssa	ssa	NOUN
hjic-87	253	4	=	=	NOUN
hjic-87	253	5	8,9	8,9	NUM
hjic-87	253	6	83,06	83,06	NUM
hjic-87	254	1	[	[	X
hjic-87	254	2	86,89	86,89	X
hjic-87	254	3	]	]	PUNCT
hjic-87	254	4	carbamazepine	carbamazepine	NOUN
hjic-87	254	5	poloxamer	poloxamer	NOUN
hjic-87	254	6	407	407	NUM
hjic-87	254	7	pvp	pvp	PROPN
hjic-87	254	8	k15	k15	PROPN
hjic-87	254	9	water	water	NOUN
hjic-87	254	10	/	/	SYM
hjic-87	254	11	thf	thf	NOUN
hjic-87	254	12	acetonitrile	acetonitrile	NOUN
hjic-87	254	13	solid	solid	ADJ
hjic-87	254	14	solution	solution	NOUN
hjic-87	254	15	mps	mp	NOUN
hjic-87	255	1	=	=	SYM
hjic-87	255	2	0,68	0,68	PROPN
hjic-87	255	3	7,06	7,06	NUM
hjic-87	255	4	ssa	ssa	NOUN
hjic-87	255	5	=	=	PROPN
hjic-87	255	6	3,88	3,88	NUM
hjic-87	255	7	13,3	13,3	NUM
hjic-87	256	1	[	[	X
hjic-87	256	2	86,91	86,91	X
hjic-87	256	3	]	]	X
hjic-87	256	4	salmon	salmon	NOUN
hjic-87	256	5	calcitonin	calcitonin	NOUN
hjic-87	256	6	,	,	PUNCT
hjic-87	256	7	tyloxapol	tyloxapol	NOUN
hjic-87	256	8	lactose	lactose	NOUN
hjic-87	256	9	water	water	NOUN
hjic-87	256	10	danazol	danazol	VERB
hjic-87	256	11	poloxamer	poloxamer	NOUN
hjic-87	256	12	407	407	NUM
hjic-87	256	13	triamcinolone	triamcinolone	PROPN
hjic-87	256	14	acetonide	acetonide	PROPN
hjic-87	256	15	poloxamer	poloxamer	NOUN
hjic-87	256	16	407	407	NUM
hjic-87	256	17	pvp	pvp	PROPN
hjic-87	256	18	k15	k15	PROPN
hjic-87	256	19	thf	thf	X
hjic-87	256	20	solid	solid	ADJ
hjic-87	256	21	solution	solution	NOUN
hjic-87	256	22	mps	mp	NOUN
hjic-87	257	1	=	=	SYM
hjic-87	257	2	5,06	5,06	NUM
hjic-87	257	3	10,49	10,49	NUM
hjic-87	257	4	ssa	ssa	NOUN
hjic-87	257	5	=	=	PROPN
hjic-87	257	6	11,04	11,04	NUM
hjic-87	258	1	19,16	19,16	NUM
hjic-87	259	1	[	[	X
hjic-87	259	2	86	86	NUM
hjic-87	259	3	]	]	PUNCT
hjic-87	259	4	danazol	danazol	ADJ
hjic-87	259	5	pvp	pvp	PROPN
hjic-87	259	6	k15	k15	PROPN
hjic-87	259	7	acetonitrile	acetonitrile	PROPN
hjic-87	259	8	dcm	dcm	PROPN
hjic-87	259	9	solid	solid	ADJ
hjic-87	259	10	solution	solution	NOUN
hjic-87	259	11	ssa	ssa	NOUN
hjic-87	259	12	=	=	SYM
hjic-87	259	13	28,50	28,50	NUM
hjic-87	259	14	-117,50	-117,50	PUNCT
hjic-87	260	1	[	[	X
hjic-87	260	2	92	92	NUM
hjic-87	260	3	]	]	PUNCT
hjic-87	260	4	a	a	DET
hjic-87	260	5	emulsion	emulsion	NOUN
hjic-87	260	6	.	.	PUNCT
hjic-87	260	7	;	;	PUNCT
hjic-87	261	1	b	b	X
hjic-87	261	2	mean	mean	VERB
hjic-87	261	3	particle	particle	NOUN
hjic-87	261	4	size	size	NOUN
hjic-87	261	5	(	(	PUNCT
hjic-87	261	6	µm	µm	NOUN
hjic-87	261	7	)	)	PUNCT
hjic-87	261	8	;	;	PUNCT
hjic-87	261	9	c	c	PROPN
hjic-87	261	10	specific	specific	ADJ
hjic-87	261	11	surface	surface	NOUN
hjic-87	261	12	area	area	NOUN
hjic-87	261	13	(	(	PUNCT
hjic-87	261	14	m2	m2	PROPN
hjic-87	261	15	/	/	SYM
hjic-87	261	16	g	g	NOUN
hjic-87	261	17	)	)	PUNCT
hjic-87	261	18	conclusion	conclusion	NOUN
hjic-87	261	19	this	this	DET
hjic-87	261	20	paper	paper	NOUN
hjic-87	261	21	aimed	aim	VERB
hjic-87	261	22	to	to	PART
hjic-87	261	23	survey	survey	VERB
hjic-87	261	24	the	the	DET
hjic-87	261	25	numerous	numerous	ADJ
hjic-87	261	26	publications	publication	NOUN
hjic-87	261	27	and	and	CCONJ
hjic-87	261	28	patents	patent	NOUN
hjic-87	261	29	issued	issue	VERB
hjic-87	261	30	to	to	ADP
hjic-87	261	31	date	date	NOUN
hjic-87	261	32	in	in	ADP
hjic-87	261	33	the	the	DET
hjic-87	261	34	fields	field	NOUN
hjic-87	261	35	of	of	ADP
hjic-87	261	36	supercritical	supercritical	ADJ
hjic-87	261	37	fluid	fluid	NOUN
hjic-87	261	38	assisted	assist	VERB
hjic-87	261	39	and	and	CCONJ
hjic-87	261	40	cryogenic	cryogenic	NOUN
hjic-87	261	41	particle	particle	NOUN
hjic-87	261	42	design	design	NOUN
hjic-87	261	43	with	with	ADP
hjic-87	261	44	special	special	ADJ
hjic-87	261	45	regard	regard	NOUN
hjic-87	261	46	to	to	ADP
hjic-87	261	47	coprecipitation	coprecipitation	NOUN
hjic-87	261	48	of	of	ADP
hjic-87	261	49	active	active	ADJ
hjic-87	261	50	substrate	substrate	NOUN
hjic-87	261	51	-	-	PUNCT
hjic-87	261	52	excipient	excipient	NOUN
hjic-87	261	53	composites	composite	NOUN
hjic-87	261	54	.	.	PUNCT
hjic-87	262	1	all	all	PRON
hjic-87	262	2	of	of	ADP
hjic-87	262	3	these	these	DET
hjic-87	262	4	techniques	technique	NOUN
hjic-87	262	5	have	have	VERB
hjic-87	262	6	their	their	PRON
hjic-87	262	7	own	own	ADJ
hjic-87	262	8	advantages	advantage	NOUN
hjic-87	262	9	and	and	CCONJ
hjic-87	262	10	drawbacks	drawback	NOUN
hjic-87	262	11	.	.	PUNCT
hjic-87	263	1	to	to	PART
hjic-87	263	2	choose	choose	VERB
hjic-87	263	3	the	the	DET
hjic-87	263	4	right	right	ADJ
hjic-87	263	5	method	method	NOUN
hjic-87	263	6	and	and	CCONJ
hjic-87	263	7	the	the	DET
hjic-87	263	8	optimal	optimal	ADJ
hjic-87	263	9	working	working	NOUN
hjic-87	263	10	conditions	condition	NOUN
hjic-87	263	11	preliminary	preliminary	ADJ
hjic-87	263	12	experiments	experiment	NOUN
hjic-87	263	13	have	have	VERB
hjic-87	263	14	to	to	PART
hjic-87	263	15	be	be	AUX
hjic-87	263	16	carried	carry	VERB
hjic-87	263	17	out	out	ADP
hjic-87	263	18	for	for	ADP
hjic-87	263	19	each	each	DET
hjic-87	263	20	api	api	NOUN
hjic-87	263	21	and/or	and/or	CCONJ
hjic-87	263	22	excipient	excipient	ADJ
hjic-87	263	23	.	.	PUNCT
hjic-87	264	1	lipophilic	lipophilic	ADJ
hjic-87	264	2	molecules	molecule	NOUN
hjic-87	264	3	are	be	AUX
hjic-87	264	4	usually	usually	ADV
hjic-87	264	5	soluble	soluble	ADJ
hjic-87	264	6	in	in	ADP
hjic-87	264	7	scfs	scfs	NOUN
hjic-87	264	8	thus	thus	ADV
hjic-87	264	9	they	they	PRON
hjic-87	264	10	can	can	AUX
hjic-87	264	11	be	be	AUX
hjic-87	264	12	processed	process	VERB
hjic-87	264	13	by	by	ADP
hjic-87	264	14	ress	ress	NOUN
hjic-87	264	15	technique	technique	NOUN
hjic-87	264	16	.	.	PUNCT
hjic-87	265	1	however	however	ADV
hjic-87	265	2	,	,	PUNCT
hjic-87	265	3	applicability	applicability	NOUN
hjic-87	265	4	of	of	ADP
hjic-87	265	5	ress	ress	PROPN
hjic-87	265	6	is	be	AUX
hjic-87	265	7	not	not	PART
hjic-87	265	8	restricted	restrict	VERB
hjic-87	265	9	to	to	ADP
hjic-87	265	10	lipophilic	lipophilic	ADJ
hjic-87	265	11	apis	apis	ADJ
hjic-87	265	12	,	,	PUNCT
hjic-87	265	13	low	low	ADJ
hjic-87	265	14	yield	yield	NOUN
hjic-87	265	15	associated	associate	VERB
hjic-87	265	16	with	with	ADP
hjic-87	265	17	polar	polar	ADJ
hjic-87	265	18	apis	apis	NOUN
hjic-87	265	19	and	and	CCONJ
hjic-87	265	20	polymers	polymer	NOUN
hjic-87	265	21	can	can	AUX
hjic-87	265	22	be	be	AUX
hjic-87	265	23	increased	increase	VERB
hjic-87	265	24	by	by	ADP
hjic-87	265	25	adding	add	VERB
hjic-87	265	26	cosolvents	cosolvent	NOUN
hjic-87	265	27	to	to	ADP
hjic-87	265	28	the	the	DET
hjic-87	265	29	scf	scf	PROPN
hjic-87	265	30	(	(	PUNCT
hjic-87	265	31	ress	ress	NOUN
hjic-87	265	32	-	-	PUNCT
hjic-87	265	33	n	n	CCONJ
hjic-87	265	34	)	)	PUNCT
hjic-87	265	35	.	.	PUNCT
hjic-87	266	1	owing	owe	VERB
hjic-87	266	2	to	to	ADP
hjic-87	266	3	the	the	DET
hjic-87	266	4	rapid	rapid	ADJ
hjic-87	266	5	expansion	expansion	NOUN
hjic-87	266	6	nucleation	nucleation	NOUN
hjic-87	266	7	is	be	AUX
hjic-87	266	8	more	more	ADV
hjic-87	266	9	important	important	ADJ
hjic-87	266	10	than	than	ADP
hjic-87	266	11	crystal	crystal	NOUN
hjic-87	266	12	growth	growth	NOUN
hjic-87	266	13	53	53	NUM
hjic-87	266	14	hence	hence	ADV
hjic-87	266	15	the	the	DET
hjic-87	266	16	sub	sub	ADJ
hjic-87	266	17	-	-	ADJ
hjic-87	266	18	micron	micron	ADJ
hjic-87	266	19	particles	particle	NOUN
hjic-87	266	20	.	.	PUNCT
hjic-87	267	1	to	to	PART
hjic-87	267	2	prevent	prevent	VERB
hjic-87	267	3	particle	particle	NOUN
hjic-87	267	4	agglomeration	agglomeration	NOUN
hjic-87	267	5	–	–	PUNCT
hjic-87	267	6	one	one	NUM
hjic-87	267	7	of	of	ADP
hjic-87	267	8	the	the	DET
hjic-87	267	9	main	main	ADJ
hjic-87	267	10	drawbacks	drawback	NOUN
hjic-87	267	11	of	of	ADP
hjic-87	267	12	ress	ress	NOUN
hjic-87	267	13	–	–	PUNCT
hjic-87	267	14	supercritical	supercritical	ADJ
hjic-87	267	15	solution	solution	NOUN
hjic-87	267	16	can	can	AUX
hjic-87	267	17	be	be	AUX
hjic-87	267	18	expanded	expand	VERB
hjic-87	267	19	into	into	ADP
hjic-87	267	20	an	an	DET
hjic-87	267	21	aqueous	aqueous	ADJ
hjic-87	267	22	solution	solution	NOUN
hjic-87	267	23	containing	contain	VERB
hjic-87	267	24	a	a	DET
hjic-87	267	25	stabilizer	stabilizer	NOUN
hjic-87	267	26	(	(	PUNCT
hjic-87	267	27	resas	resas	NOUN
hjic-87	267	28	,	,	PUNCT
hjic-87	267	29	relgs	relgs	NOUN
hjic-87	267	30	-	-	PUNCT
hjic-87	267	31	h	h	NOUN
hjic-87	267	32	)	)	PUNCT
hjic-87	267	33	.	.	PUNCT
hjic-87	268	1	additional	additional	ADJ
hjic-87	268	2	stabilizers	stabilizer	NOUN
hjic-87	268	3	can	can	AUX
hjic-87	268	4	minimize	minimize	VERB
hjic-87	268	5	particle	particle	NOUN
hjic-87	268	6	aggregation	aggregation	NOUN
hjic-87	268	7	and	and	CCONJ
hjic-87	268	8	reduce	reduce	VERB
hjic-87	268	9	the	the	DET
hjic-87	268	10	mean	mean	ADJ
hjic-87	268	11	particle	particle	NOUN
hjic-87	268	12	size	size	NOUN
hjic-87	268	13	by	by	ADP
hjic-87	268	14	orders	order	NOUN
hjic-87	268	15	of	of	ADP
hjic-87	268	16	magnitude	magnitude	NOUN
hjic-87	268	17	[	[	X
hjic-87	268	18	14	14	NUM
hjic-87	268	19	]	]	PUNCT
hjic-87	268	20	.	.	PUNCT
hjic-87	269	1	unlike	unlike	ADP
hjic-87	269	2	the	the	DET
hjic-87	269	3	ress	ress	NOUN
hjic-87	269	4	,	,	PUNCT
hjic-87	269	5	pgss	pgss	NOUN
hjic-87	269	6	is	be	AUX
hjic-87	269	7	applicable	applicable	ADJ
hjic-87	269	8	whether	whether	SCONJ
hjic-87	269	9	the	the	DET
hjic-87	269	10	apiexcipient	apiexcipient	NOUN
hjic-87	269	11	is	be	AUX
hjic-87	269	12	soluble	soluble	ADJ
hjic-87	269	13	in	in	ADP
hjic-87	269	14	scf	scf	PROPN
hjic-87	269	15	or	or	CCONJ
hjic-87	269	16	not	not	PART
hjic-87	269	17	.	.	PUNCT
hjic-87	270	1	this	this	DET
hjic-87	270	2	tecnique	tecnique	NOUN
hjic-87	270	3	was	be	AUX
hjic-87	270	4	developed	develop	VERB
hjic-87	270	5	in	in	ADP
hjic-87	270	6	paint	paint	NOUN
hjic-87	270	7	and	and	CCONJ
hjic-87	270	8	polymer	polymer	NOUN
hjic-87	270	9	industry	industry	NOUN
hjic-87	270	10	to	to	PART
hjic-87	270	11	prepare	prepare	VERB
hjic-87	270	12	coated	coated	ADJ
hjic-87	270	13	micro	micro	NOUN
hjic-87	270	14	-	-	NOUN
hjic-87	270	15	particles	particle	NOUN
hjic-87	270	16	.	.	PUNCT
hjic-87	271	1	as	as	SCONJ
hjic-87	271	2	most	most	ADJ
hjic-87	271	3	polymers	polymer	NOUN
hjic-87	271	4	swell	swell	VERB
hjic-87	271	5	and	and	CCONJ
hjic-87	271	6	melt	melt	VERB
hjic-87	271	7	at	at	ADP
hjic-87	271	8	lower	low	ADJ
hjic-87	271	9	temperature	temperature	NOUN
hjic-87	271	10	when	when	SCONJ
hjic-87	271	11	placed	place	VERB
hjic-87	271	12	in	in	ADP
hjic-87	271	13	high	high	ADJ
hjic-87	271	14	pressure	pressure	NOUN
hjic-87	271	15	co2	co2	NOUN
hjic-87	271	16	,	,	PUNCT
hjic-87	271	17	thermolabil	thermolabil	ADJ
hjic-87	271	18	apis	apis	PROPN
hjic-87	271	19	(	(	PUNCT
hjic-87	271	20	peptides	peptide	NOUN
hjic-87	271	21	,	,	PUNCT
hjic-87	271	22	enzymes	enzyme	NOUN
hjic-87	271	23	,	,	PUNCT
hjic-87	271	24	viruses	virus	NOUN
hjic-87	271	25	)	)	PUNCT
hjic-87	271	26	can	can	AUX
hjic-87	271	27	be	be	AUX
hjic-87	271	28	as	as	ADV
hjic-87	271	29	well	well	ADV
hjic-87	271	30	encapsulated	encapsulate	VERB
hjic-87	271	31	without	without	ADP
hjic-87	271	32	considerable	considerable	ADJ
hjic-87	271	33	decrease	decrease	NOUN
hjic-87	271	34	of	of	ADP
hjic-87	271	35	their	their	PRON
hjic-87	271	36	biological	biological	ADJ
hjic-87	271	37	activity	activity	NOUN
hjic-87	271	38	(	(	PUNCT
hjic-87	271	39	pluss	pluss	NOUN
hjic-87	271	40	)	)	PUNCT
hjic-87	271	41	.	.	PUNCT
hjic-87	272	1	in	in	ADP
hjic-87	272	2	contrast	contrast	NOUN
hjic-87	272	3	to	to	ADP
hjic-87	272	4	pgss	pgss	ADJ
hjic-87	272	5	,	,	PUNCT
hjic-87	272	6	supercritical	supercritical	ADJ
hjic-87	272	7	antisolvent	antisolvent	NOUN
hjic-87	272	8	techniques	technique	NOUN
hjic-87	272	9	(	(	PUNCT
hjic-87	272	10	gas	gas	NOUN
hjic-87	272	11	,	,	PUNCT
hjic-87	272	12	sas	sas	PROPN
hjic-87	272	13	,	,	PUNCT
hjic-87	272	14	seds	sed	NOUN
hjic-87	272	15	,	,	PUNCT
hjic-87	272	16	ases	as	NOUN
hjic-87	272	17	,	,	PUNCT
hjic-87	272	18	and	and	CCONJ
hjic-87	272	19	pca	pca	PROPN
hjic-87	272	20	)	)	PUNCT
hjic-87	272	21	require	require	VERB
hjic-87	272	22	a	a	DET
hjic-87	272	23	solvent	solvent	NOUN
hjic-87	272	24	wherein	wherein	SCONJ
hjic-87	272	25	the	the	DET
hjic-87	272	26	api	api	NOUN
hjic-87	272	27	and	and	CCONJ
hjic-87	272	28	excipient	excipient	NOUN
hjic-87	272	29	are	be	AUX
hjic-87	272	30	dissolved	dissolve	VERB
hjic-87	272	31	and	and	CCONJ
hjic-87	272	32	which	which	PRON
hjic-87	272	33	is	be	AUX
hjic-87	272	34	miscible	miscible	ADJ
hjic-87	272	35	with	with	ADP
hjic-87	272	36	the	the	DET
hjic-87	272	37	scf	scf	PROPN
hjic-87	272	38	at	at	ADP
hjic-87	272	39	working	work	VERB
hjic-87	272	40	conditions	condition	NOUN
hjic-87	272	41	.	.	PUNCT
hjic-87	273	1	the	the	DET
hjic-87	273	2	fact	fact	NOUN
hjic-87	273	3	that	that	SCONJ
hjic-87	273	4	these	these	DET
hjic-87	273	5	techniques	technique	NOUN
hjic-87	273	6	use	use	VERB
hjic-87	273	7	scfs	scfs	NOUN
hjic-87	273	8	as	as	SCONJ
hjic-87	273	9	antisolvents	antisolvent	NOUN
hjic-87	273	10	make	make	VERB
hjic-87	273	11	them	they	PRON
hjic-87	273	12	available	available	ADJ
hjic-87	273	13	for	for	ADP
hjic-87	273	14	a	a	DET
hjic-87	273	15	wide	wide	ADJ
hjic-87	273	16	range	range	NOUN
hjic-87	273	17	of	of	ADP
hjic-87	273	18	apis	apis	NOUN
hjic-87	273	19	and	and	CCONJ
hjic-87	273	20	excipients	excipient	NOUN
hjic-87	273	21	and	and	CCONJ
hjic-87	273	22	allow	allow	VERB
hjic-87	273	23	milder	mild	ADJ
hjic-87	273	24	working	working	NOUN
hjic-87	273	25	conditions	condition	NOUN
hjic-87	273	26	compared	compare	VERB
hjic-87	273	27	to	to	ADP
hjic-87	273	28	ress	ress	NOUN
hjic-87	273	29	.	.	PUNCT
hjic-87	274	1	furthermore	furthermore	ADV
hjic-87	274	2	they	they	PRON
hjic-87	274	3	provide	provide	VERB
hjic-87	274	4	additional	additional	ADJ
hjic-87	274	5	operating	operating	NOUN
hjic-87	274	6	variables	variable	NOUN
hjic-87	274	7	i.e.	i.e.	X
hjic-87	274	8	flow	flow	NOUN
hjic-87	274	9	rates	rate	NOUN
hjic-87	274	10	,	,	PUNCT
hjic-87	274	11	concentrations	concentration	NOUN
hjic-87	274	12	,	,	PUNCT
hjic-87	274	13	nozzle	nozzle	NOUN
hjic-87	274	14	diameter	diameter	NOUN
hjic-87	274	15	and	and	CCONJ
hjic-87	274	16	solvent	solvent	NOUN
hjic-87	274	17	,	,	PUNCT
hjic-87	274	18	some	some	PRON
hjic-87	274	19	of	of	ADP
hjic-87	274	20	which	which	PRON
hjic-87	274	21	proved	prove	VERB
hjic-87	274	22	to	to	PART
hjic-87	274	23	be	be	AUX
hjic-87	274	24	critical	critical	ADJ
hjic-87	274	25	in	in	ADP
hjic-87	274	26	terms	term	NOUN
hjic-87	274	27	of	of	ADP
hjic-87	274	28	particle	particle	NOUN
hjic-87	274	29	size	size	NOUN
hjic-87	274	30	,	,	PUNCT
hjic-87	274	31	morphology	morphology	NOUN
hjic-87	274	32	,	,	PUNCT
hjic-87	274	33	polymorphism	polymorphism	NOUN
hjic-87	274	34	and	and	CCONJ
hjic-87	274	35	crystallinity	crystallinity	NOUN
hjic-87	274	36	[	[	X
hjic-87	274	37	93	93	NUM
hjic-87	274	38	]	]	PUNCT
hjic-87	274	39	.	.	PUNCT
hjic-87	275	1	aqueous	aqueous	ADJ
hjic-87	275	2	solutions	solution	NOUN
hjic-87	275	3	can	can	AUX
hjic-87	275	4	be	be	AUX
hjic-87	275	5	processed	process	VERB
hjic-87	275	6	as	as	ADV
hjic-87	275	7	well	well	ADV
hjic-87	275	8	with	with	ADP
hjic-87	275	9	cosolvents	cosolvent	NOUN
hjic-87	275	10	(	(	PUNCT
hjic-87	275	11	ethanol	ethanol	NOUN
hjic-87	275	12	or	or	CCONJ
hjic-87	275	13	methanol	methanol	NOUN
hjic-87	275	14	)	)	PUNCT
hjic-87	275	15	mixed	mix	VERB
hjic-87	275	16	in	in	ADP
hjic-87	275	17	a	a	DET
hjic-87	275	18	three	three	NUM
hjic-87	275	19	-	-	PUNCT
hjic-87	275	20	passage	passage	NOUN
hjic-87	275	21	nozzle	nozzle	NOUN
hjic-87	275	22	[	[	X
hjic-87	275	23	64	64	NUM
hjic-87	275	24	]	]	PUNCT
hjic-87	275	25	.	.	PUNCT
hjic-87	276	1	scf	scf	PROPN
hjic-87	276	2	assisted	assist	VERB
hjic-87	276	3	precipitation	precipitation	NOUN
hjic-87	276	4	techniques	technique	NOUN
hjic-87	276	5	are	be	AUX
hjic-87	276	6	successful	successful	ADJ
hjic-87	276	7	candidates	candidate	NOUN
hjic-87	276	8	for	for	ADP
hjic-87	276	9	drug	drug	NOUN
hjic-87	276	10	-	-	PUNCT
hjic-87	276	11	excipient	excipient	NOUN
hjic-87	276	12	coformulation	coformulation	NOUN
hjic-87	276	13	for	for	ADP
hjic-87	276	14	controlled	control	VERB
hjic-87	276	15	release	release	NOUN
hjic-87	276	16	dosage	dosage	NOUN
hjic-87	276	17	forms	form	NOUN
hjic-87	276	18	.	.	PUNCT
hjic-87	277	1	however	however	ADV
hjic-87	277	2	amorphous	amorphous	ADJ
hjic-87	277	3	solid	solid	ADJ
hjic-87	277	4	solutions	solution	NOUN
hjic-87	277	5	are	be	AUX
hjic-87	277	6	great	great	ADJ
hjic-87	277	7	challenge	challenge	NOUN
hjic-87	277	8	for	for	ADP
hjic-87	277	9	scf	scf	PROPN
hjic-87	277	10	assisted	assist	VERB
hjic-87	277	11	particle	particle	NOUN
hjic-87	277	12	design	design	NOUN
hjic-87	277	13	,	,	PUNCT
hjic-87	277	14	as	as	SCONJ
hjic-87	277	15	it	it	PRON
hjic-87	277	16	’s	’	VERB
hjic-87	277	17	not	not	PART
hjic-87	277	18	always	always	ADV
hjic-87	277	19	possible	possible	ADJ
hjic-87	277	20	to	to	PART
hjic-87	277	21	reduce	reduce	VERB
hjic-87	277	22	product	product	NOUN
hjic-87	277	23	crystallinity	crystallinity	NOUN
hjic-87	277	24	to	to	ADP
hjic-87	277	25	zero	zero	NUM
hjic-87	277	26	[	[	X
hjic-87	277	27	67,69	67,69	NOUN
hjic-87	277	28	]	]	PUNCT
hjic-87	277	29	.	.	PUNCT
hjic-87	278	1	pharmaceutical	pharmaceutical	NOUN
hjic-87	278	2	formulations	formulation	NOUN
hjic-87	278	3	using	use	VERB
hjic-87	278	4	cryogenic	cryogenic	NOUN
hjic-87	278	5	fluids	fluid	NOUN
hjic-87	278	6	were	be	AUX
hjic-87	278	7	originally	originally	ADV
hjic-87	278	8	developed	develop	VERB
hjic-87	278	9	to	to	PART
hjic-87	278	10	blend	blend	VERB
hjic-87	278	11	thermolabil	thermolabil	ADJ
hjic-87	278	12	biological	biological	ADJ
hjic-87	278	13	substances	substance	NOUN
hjic-87	278	14	(	(	PUNCT
hjic-87	278	15	peptides	peptide	NOUN
hjic-87	278	16	,	,	PUNCT
hjic-87	278	17	enzymes	enzyme	NOUN
hjic-87	278	18	,	,	PUNCT
hjic-87	278	19	cells	cell	NOUN
hjic-87	278	20	)	)	PUNCT
hjic-87	278	21	preserving	preserve	VERB
hjic-87	278	22	their	their	PRON
hjic-87	278	23	biological	biological	ADJ
hjic-87	278	24	activities	activity	NOUN
hjic-87	278	25	[	[	X
hjic-87	278	26	74	74	NUM
hjic-87	278	27	-	-	SYM
hjic-87	278	28	76	76	NUM
hjic-87	278	29	]	]	PUNCT
hjic-87	278	30	.	.	PUNCT
hjic-87	279	1	in	in	ADP
hjic-87	279	2	recent	recent	ADJ
hjic-87	279	3	years	year	NOUN
hjic-87	279	4	,	,	PUNCT
hjic-87	279	5	williams	williams	PROPN
hjic-87	279	6	and	and	CCONJ
hjic-87	279	7	co	co	NOUN
hjic-87	279	8	workers	worker	NOUN
hjic-87	279	9	pointed	point	VERB
hjic-87	279	10	out	out	ADP
hjic-87	279	11	that	that	SCONJ
hjic-87	279	12	formulation	formulation	NOUN
hjic-87	279	13	processes	process	NOUN
hjic-87	279	14	using	use	VERB
hjic-87	279	15	liquefied	liquefy	VERB
hjic-87	279	16	gases	gas	NOUN
hjic-87	279	17	can	can	AUX
hjic-87	279	18	be	be	AUX
hjic-87	279	19	successfully	successfully	ADV
hjic-87	279	20	applied	apply	VERB
hjic-87	279	21	to	to	PART
hjic-87	279	22	enhance	enhance	VERB
hjic-87	279	23	the	the	DET
hjic-87	279	24	solubility	solubility	NOUN
hjic-87	279	25	of	of	ADP
hjic-87	279	26	poorly	poorly	ADV
hjic-87	279	27	water	water	NOUN
hjic-87	279	28	soluble	soluble	ADJ
hjic-87	279	29	or	or	CCONJ
hjic-87	279	30	insoluble	insoluble	ADJ
hjic-87	279	31	apis	apis	NOUN
hjic-87	279	32	.	.	PUNCT
hjic-87	280	1	apart	apart	ADV
hjic-87	280	2	from	from	ADP
hjic-87	280	3	applied	applied	ADJ
hjic-87	280	4	solvent	solvent	NOUN
hjic-87	280	5	(	(	PUNCT
hjic-87	280	6	organic	organic	ADJ
hjic-87	280	7	solvent	solvent	NOUN
hjic-87	280	8	,	,	PUNCT
hjic-87	280	9	aqueous	aqueous	ADJ
hjic-87	280	10	solutions	solution	NOUN
hjic-87	280	11	or	or	CCONJ
hjic-87	280	12	emulsion	emulsion	NOUN
hjic-87	280	13	)	)	PUNCT
hjic-87	280	14	coformulations	coformulation	NOUN
hjic-87	280	15	contained	contain	VERB
hjic-87	280	16	fine	fine	ADJ
hjic-87	280	17	microparticles	microparticle	NOUN
hjic-87	280	18	of	of	ADP
hjic-87	280	19	amorphous	amorphous	ADJ
hjic-87	280	20	solid	solid	ADJ
hjic-87	280	21	solution	solution	NOUN
hjic-87	280	22	with	with	ADP
hjic-87	280	23	great	great	ADJ
hjic-87	280	24	specific	specific	ADJ
hjic-87	280	25	surface	surface	NOUN
hjic-87	280	26	area	area	NOUN
hjic-87	280	27	,	,	PUNCT
hjic-87	280	28	enhanced	enhance	VERB
hjic-87	280	29	solubility	solubility	NOUN
hjic-87	280	30	and	and	CCONJ
hjic-87	280	31	low	low	ADJ
hjic-87	280	32	residual	residual	ADJ
hjic-87	280	33	solvent	solvent	NOUN
hjic-87	280	34	content	content	NOUN
hjic-87	280	35	.	.	PUNCT
hjic-87	281	1	in	in	ADP
hjic-87	281	2	future	future	NOUN
hjic-87	281	3	,	,	PUNCT
hjic-87	281	4	scf	scf	PROPN
hjic-87	281	5	assisted	assisted	ADJ
hjic-87	281	6	and	and	CCONJ
hjic-87	281	7	cryogenic	cryogenic	NOUN
hjic-87	281	8	particle	particle	NOUN
hjic-87	281	9	design	design	NOUN
hjic-87	281	10	technologies	technology	NOUN
hjic-87	281	11	can	can	AUX
hjic-87	281	12	be	be	AUX
hjic-87	281	13	alternatives	alternative	NOUN
hjic-87	281	14	to	to	ADP
hjic-87	281	15	conventional	conventional	ADJ
hjic-87	281	16	formulation	formulation	NOUN
hjic-87	281	17	techniques	technique	NOUN
hjic-87	281	18	due	due	ADP
hjic-87	281	19	to	to	ADP
hjic-87	281	20	their	their	PRON
hjic-87	281	21	ability	ability	NOUN
hjic-87	281	22	to	to	PART
hjic-87	281	23	produce	produce	VERB
hjic-87	281	24	micro	micro	NOUN
hjic-87	281	25	-	-	NOUN
hjic-87	281	26	particles	particle	NOUN
hjic-87	281	27	with	with	ADP
hjic-87	281	28	targeted	target	VERB
hjic-87	281	29	physical	physical	ADJ
hjic-87	281	30	properties	property	NOUN
hjic-87	281	31	including	include	VERB
hjic-87	281	32	particle	particle	NOUN
hjic-87	281	33	size	size	NOUN
hjic-87	281	34	,	,	PUNCT
hjic-87	281	35	morphology	morphology	NOUN
hjic-87	281	36	,	,	PUNCT
hjic-87	281	37	crystallinity	crystallinity	NOUN
hjic-87	281	38	,	,	PUNCT
hjic-87	281	39	polymorphism	polymorphism	NOUN
hjic-87	281	40	and	and	CCONJ
hjic-87	281	41	residual	residual	ADJ
hjic-87	281	42	solvent	solvent	NOUN
hjic-87	281	43	content	content	NOUN
hjic-87	281	44	.	.	PUNCT
hjic-87	282	1	references	reference	NOUN
hjic-87	282	2	1	1	NUM
hjic-87	282	3	.	.	PUNCT
hjic-87	282	4	jung	jung	PROPN
hjic-87	282	5	j.	j.	PROPN
hjic-87	282	6	and	and	CCONJ
hjic-87	282	7	perrut	perrut	PROPN
hjic-87	282	8	m.	m.	NOUN
hjic-87	282	9	:	:	PUNCT
hjic-87	282	10	j.	j.	PROPN
hjic-87	282	11	supercrit	supercrit	PROPN
hjic-87	282	12	.	.	PUNCT
hjic-87	282	13	fluids	fluid	NOUN
hjic-87	282	14	,	,	PUNCT
hjic-87	282	15	2001	2001	NUM
hjic-87	282	16	,	,	PUNCT
hjic-87	282	17	20	20	NUM
hjic-87	282	18	,	,	PUNCT
hjic-87	282	19	179	179	NUM
hjic-87	282	20	-	-	SYM
hjic-87	282	21	219	219	NUM
hjic-87	282	22	2	2	NUM
hjic-87	282	23	.	.	PUNCT
hjic-87	282	24	leuner	leuner	PROPN
hjic-87	282	25	c.	c.	PROPN
hjic-87	282	26	and	and	CCONJ
hjic-87	282	27	dressman	dressman	PROPN
hjic-87	282	28	j.	j.	PROPN
hjic-87	282	29	:	:	PROPN
hjic-87	282	30	eur	eur	PROPN
hjic-87	282	31	.	.	PUNCT
hjic-87	283	1	j.	j.	PROPN
hjic-87	283	2	pharma	pharma	PROPN
hjic-87	283	3	.	.	PUNCT
hjic-87	284	1	biopharma	biopharma	PROPN
hjic-87	284	2	.	.	PUNCT
hjic-87	284	3	,	,	PUNCT
hjic-87	284	4	2000	2000	NUM
hjic-87	284	5	,	,	PUNCT
hjic-87	284	6	50(1	50(1	NUM
hjic-87	284	7	)	)	PUNCT
hjic-87	284	8	,	,	PUNCT
hjic-87	284	9	47	47	NUM
hjic-87	284	10	-	-	SYM
hjic-87	284	11	60	60	NUM
hjic-87	284	12	3	3	NUM
hjic-87	284	13	.	.	PUNCT
hjic-87	284	14	corrigan	corrigan	PROPN
hjic-87	284	15	o.	o.	PROPN
hjic-87	284	16	i.	i.	PROPN
hjic-87	284	17	and	and	CCONJ
hjic-87	284	18	crean	crean	PROPN
hjic-87	284	19	a.	a.	PROPN
hjic-87	284	20	m.	m.	NOUN
hjic-87	284	21	:	:	PUNCT
hjic-87	284	22	int	int	NOUN
hjic-87	284	23	.	.	PUNCT
hjic-87	285	1	j.	j.	PROPN
hjic-87	285	2	pharm	pharm	PROPN
hjic-87	285	3	.	.	PROPN
hjic-87	285	4	,	,	PUNCT
hjic-87	285	5	2002	2002	NUM
hjic-87	285	6	,	,	PUNCT
hjic-87	285	7	245	245	NUM
hjic-87	285	8	,	,	PUNCT
hjic-87	285	9	75	75	NUM
hjic-87	285	10	-	-	SYM
hjic-87	285	11	82	82	NUM
hjic-87	285	12	4	4	NUM
hjic-87	285	13	.	.	PUNCT
hjic-87	286	1	hannay	hannay	PROPN
hjic-87	286	2	j.	j.	PROPN
hjic-87	286	3	b.	b.	PROPN
hjic-87	286	4	and	and	CCONJ
hjic-87	286	5	hoghart	hoghart	PROPN
hjic-87	286	6	j.	j.	PROPN
hjic-87	286	7	:	:	PUNCT
hjic-87	286	8	proc	proc	PROPN
hjic-87	286	9	.	.	PUNCT
hjic-87	287	1	roy	roy	PROPN
hjic-87	287	2	.	.	PROPN
hjic-87	287	3	sec	sec	PROPN
hjic-87	287	4	.	.	PROPN
hjic-87	287	5	,	,	PUNCT
hjic-87	287	6	1879	1879	NUM
hjic-87	287	7	,	,	PUNCT
hjic-87	287	8	29	29	NUM
hjic-87	287	9	,	,	PUNCT
hjic-87	287	10	324	324	NUM
hjic-87	287	11	5	5	NUM
hjic-87	287	12	.	.	PUNCT
hjic-87	287	13	kompella	kompella	PROPN
hjic-87	287	14	u.	u.	PROPN
hjic-87	287	15	b.	b.	PROPN
hjic-87	287	16	,	,	PUNCT
hjic-87	287	17	koushik	koushik	PROPN
hjic-87	287	18	k.	k.	PROPN
hjic-87	287	19	:	:	PUNCT
hjic-87	287	20	crit	crit	PROPN
hjic-87	287	21	.	.	PUNCT
hjic-87	288	1	rev	rev	PROPN
hjic-87	288	2	.	.	PROPN
hjic-87	289	1	ther	ther	PROPN
hjic-87	289	2	.	.	PUNCT
hjic-87	290	1	drug	drug	NOUN
hjic-87	290	2	.	.	PUNCT
hjic-87	290	3	carrier	carrier	NOUN
hjic-87	290	4	.	.	PUNCT
hjic-87	291	1	syst	syst	PROPN
hjic-87	291	2	.	.	PROPN
hjic-87	291	3	,	,	PUNCT
hjic-87	291	4	2001	2001	NUM
hjic-87	291	5	,	,	PUNCT
hjic-87	291	6	18(2	18(2	NUM
hjic-87	291	7	)	)	PUNCT
hjic-87	291	8	,	,	PUNCT
hjic-87	291	9	173	173	NUM
hjic-87	291	10	-	-	SYM
hjic-87	291	11	99	99	NUM
hjic-87	291	12	6	6	NUM
hjic-87	291	13	.	.	PUNCT
hjic-87	292	1	mishima	mishima	PROPN
hjic-87	292	2	k.	k.	PROPN
hjic-87	292	3	,	,	PUNCT
hjic-87	292	4	yamaguchi	yamaguchi	PROPN
hjic-87	292	5	s.	s.	PROPN
hjic-87	292	6	and	and	CCONJ
hjic-87	292	7	umemot	umemot	PROPN
hjic-87	292	8	h.	h.	PROPN
hjic-87	292	9	,	,	PUNCT
hjic-87	292	10	jp	jp	PROPN
hjic-87	293	1	pat	pat	PROPN
hjic-87	293	2	.	.	PROPN
hjic-87	293	3	8,104,830	8,104,830	NUM
hjic-87	293	4	(	(	PUNCT
hjic-87	293	5	1996	1996	NUM
hjic-87	293	6	)	)	PUNCT
hjic-87	293	7	7	7	NUM
hjic-87	293	8	.	.	PUNCT
hjic-87	293	9	mishima	mishima	PROPN
hjic-87	293	10	k.	k.	PROPN
hjic-87	293	11	,	,	PUNCT
hjic-87	293	12	matsuyama	matsuyama	PROPN
hjic-87	293	13	k.	k.	PROPN
hjic-87	293	14	,	,	PUNCT
hjic-87	293	15	uchiyama	uchiyama	NOUN
hjic-87	293	16	h.and	h.and	PROPN
hjic-87	293	17	ide	ide	ADJ
hjic-87	293	18	m.	m.	NOUN
hjic-87	293	19	:	:	PUNCT
hjic-87	293	20	microcoating	microcoating	NOUN
hjic-87	293	21	of	of	ADP
hjic-87	293	22	flavone	flavone	NOUN
hjic-87	293	23	and	and	CCONJ
hjic-87	293	24	3hydroxyflavone	3hydroxyflavone	NUM
hjic-87	293	25	with	with	ADP
hjic-87	293	26	polymer	polymer	NOUN
hjic-87	293	27	using	use	VERB
hjic-87	293	28	supercritical	supercritical	ADJ
hjic-87	293	29	carbon	carbon	NOUN
hjic-87	293	30	dioxide	dioxide	NOUN
hjic-87	293	31	.	.	PUNCT
hjic-87	294	1	the	the	DET
hjic-87	294	2	4th	4th	ADJ
hjic-87	294	3	international	international	ADJ
hjic-87	294	4	symposium	symposium	NOUN
hjic-87	294	5	on	on	ADP
hjic-87	294	6	supercritical	supercritical	ADJ
hjic-87	294	7	fluids	fluid	NOUN
hjic-87	294	8	,	,	PUNCT
hjic-87	294	9	sendai	sendai	PROPN
hjic-87	294	10	(	(	PUNCT
hjic-87	294	11	japan	japan	PROPN
hjic-87	294	12	)	)	PUNCT
hjic-87	294	13	,	,	PUNCT
hjic-87	294	14	1114	1114	NUM
hjic-87	294	15	may	may	AUX
hjic-87	294	16	,	,	PUNCT
hjic-87	294	17	1997	1997	NUM
hjic-87	294	18	,	,	PUNCT
hjic-87	294	19	267270	267270	NUM
hjic-87	294	20	8	8	NUM
hjic-87	294	21	.	.	PUNCT
hjic-87	295	1	mishima	mishima	PROPN
hjic-87	295	2	k.	k.	PROPN
hjic-87	295	3	,	,	PUNCT
hjic-87	295	4	matsuyama	matsuyama	PROPN
hjic-87	295	5	k.	k.	PROPN
hjic-87	295	6	,	,	PUNCT
hjic-87	295	7	yamaguchi	yamaguchi	PROPN
hjic-87	295	8	s.	s.	PROPN
hjic-87	295	9	,	,	PUNCT
hjic-87	295	10	izumi	izumi	PROPN
hjic-87	295	11	h.	h.	PROPN
hjic-87	295	12	,	,	PUNCT
hjic-87	295	13	furudono	furudono	PROPN
hjic-87	295	14	d.	d.	PROPN
hjic-87	295	15	:	:	PUNCT
hjic-87	295	16	(	(	PUNCT
hjic-87	295	17	2000a	2000a	NOUN
hjic-87	295	18	)	)	PUNCT
hjic-87	295	19	novel	novel	ADJ
hjic-87	295	20	control	control	NOUN
hjic-87	295	21	of	of	ADP
hjic-87	295	22	crystallinity	crystallinity	NOUN
hjic-87	295	23	and	and	CCONJ
hjic-87	295	24	coating	coat	VERB
hjic-87	295	25	thickness	thickness	NOUN
hjic-87	295	26	of	of	ADP
hjic-87	295	27	polymeric	polymeric	ADJ
hjic-87	295	28	microcapsules	microcapsule	NOUN
hjic-87	295	29	of	of	ADP
hjic-87	295	30	medicine	medicine	NOUN
hjic-87	295	31	by	by	ADP
hjic-87	295	32	cosolvency	cosolvency	NOUN
hjic-87	295	33	of	of	ADP
hjic-87	295	34	supercritical	supercritical	ADJ
hjic-87	295	35	solution	solution	NOUN
hjic-87	295	36	.	.	PUNCT
hjic-87	296	1	proceedings	proceeding	NOUN
hjic-87	296	2	of	of	ADP
hjic-87	296	3	the	the	DET
hjic-87	296	4	5th	5th	ADJ
hjic-87	296	5	international	international	ADJ
hjic-87	296	6	symposium	symposium	NOUN
hjic-87	296	7	on	on	ADP
hjic-87	296	8	supercritical	supercritical	ADJ
hjic-87	296	9	fluids	fluid	NOUN
hjic-87	296	10	,	,	PUNCT
hjic-87	296	11	812	812	NUM
hjic-87	296	12	april	april	PROPN
hjic-87	296	13	,	,	PUNCT
hjic-87	296	14	atlanta	atlanta	PROPN
hjic-87	296	15	(	(	PUNCT
hjic-87	296	16	usa	usa	PROPN
hjic-87	296	17	)	)	PUNCT
hjic-87	296	18	,	,	PUNCT
hjic-87	296	19	2000	2000	NUM
hjic-87	296	20	.	.	PUNCT
hjic-87	297	1	9	9	X
hjic-87	297	2	.	.	X
hjic-87	297	3	mishima	mishima	PROPN
hjic-87	297	4	k.	k.	PROPN
hjic-87	297	5	,	,	PUNCT
hjic-87	297	6	matsuyama	matsuyama	PROPN
hjic-87	297	7	k.	k.	PROPN
hjic-87	297	8	,	,	PUNCT
hjic-87	297	9	tanabe	tanabe	PROPN
hjic-87	297	10	d.	d.	PROPN
hjic-87	297	11	,	,	PUNCT
hjic-87	297	12	yamaguchi	yamaguchi	PROPN
hjic-87	297	13	s.	s.	PROPN
hjic-87	297	14	,	,	PUNCT
hjic-87	297	15	young	young	ADJ
hjic-87	297	16	t.	t.	PROPN
hjic-87	297	17	j.	j.	PROPN
hjic-87	297	18	and	and	CCONJ
hjic-87	297	19	johnston	johnston	PROPN
hjic-87	297	20	k.	k.	PROPN
hjic-87	297	21	p.	p.	PROPN
hjic-87	297	22	:	:	PUNCT
hjic-87	297	23	aiche	aiche	PROPN
hjic-87	297	24	journal	journal	PROPN
hjic-87	297	25	,	,	PUNCT
hjic-87	297	26	2000b	2000b	NUM
hjic-87	297	27	,	,	PUNCT
hjic-87	297	28	46(4	46(4	NOUN
hjic-87	297	29	)	)	PUNCT
hjic-87	297	30	,	,	PUNCT
hjic-87	297	31	857	857	NUM
hjic-87	297	32	-	-	SYM
hjic-87	297	33	865	865	NUM
hjic-87	297	34	10	10	NUM
hjic-87	297	35	.	.	PUNCT
hjic-87	298	1	frederiksen	frederiksen	PROPN
hjic-87	298	2	l.	l.	PROPN
hjic-87	298	3	,	,	PUNCT
hjic-87	298	4	anton	anton	PROPN
hjic-87	298	5	k.	k.	PROPN
hjic-87	298	6	and	and	CCONJ
hjic-87	298	7	van	van	PROPN
hjic-87	298	8	hoogevest	hoogevest	PROPN
hjic-87	298	9	p.	p.	NOUN
hjic-87	298	10	:	:	PUNCT
hjic-87	298	11	(	(	PUNCT
hjic-87	298	12	1994	1994	NUM
hjic-87	298	13	)	)	PUNCT
hjic-87	298	14	e.p	e.p	PROPN
hjic-87	298	15	.	.	PROPN
hjic-87	298	16	pat	pat	PROPN
hjic-87	298	17	.	.	PROPN
hjic-87	298	18	0,616,801	0,616,801	NUM
hjic-87	298	19	11	11	NUM
hjic-87	298	20	.	.	PUNCT
hjic-87	299	1	frederiksen	frederiksen	PROPN
hjic-87	299	2	l.	l.	PROPN
hjic-87	299	3	,	,	PUNCT
hjic-87	299	4	anton	anton	PROPN
hjic-87	299	5	k.	k.	PROPN
hjic-87	299	6	,	,	PUNCT
hjic-87	299	7	van	van	PROPN
hjic-87	299	8	hoogevest	hoogevest	PROPN
hjic-87	299	9	p.	p.	PROPN
hjic-87	299	10	,	,	PUNCT
hjic-87	299	11	keller	keller	PROPN
hjic-87	299	12	h.	h.	PROPN
hjic-87	299	13	r.	r.	PROPN
hjic-87	299	14	and	and	CCONJ
hjic-87	299	15	leuenberger	leuenberg	ADJ
hjic-87	299	16	h.	h.	PROPN
hjic-87	299	17	:	:	PUNCT
hjic-87	299	18	j.	j.	PROPN
hjic-87	299	19	of	of	ADP
hjic-87	299	20	pharm	pharm	PROPN
hjic-87	299	21	.	.	PUNCT
hjic-87	300	1	sci	sci	PROPN
hjic-87	300	2	.	.	PROPN
hjic-87	300	3	,	,	PUNCT
hjic-87	300	4	1997	1997	NUM
hjic-87	300	5	,	,	PUNCT
hjic-87	300	6	86	86	NUM
hjic-87	300	7	(	(	PUNCT
hjic-87	300	8	8)	8)	NUM
hjic-87	300	9	921	921	NUM
hjic-87	300	10	-	-	SYM
hjic-87	300	11	928	928	NUM
hjic-87	300	12	12	12	NUM
hjic-87	300	13	.	.	PUNCT
hjic-87	301	1	ma	ma	PROPN
hjic-87	301	2	s.	s.	PROPN
hjic-87	301	3	:	:	PUNCT
hjic-87	302	1	cn	cn	PROPN
hjic-87	302	2	pat	pat	PROPN
hjic-87	302	3	.	.	PROPN
hjic-87	302	4	1,221,607	1,221,607	NUM
hjic-87	302	5	(	(	PUNCT
hjic-87	302	6	1999	1999	NUM
hjic-87	302	7	)	)	PUNCT
hjic-87	302	8	13	13	NUM
hjic-87	302	9	.	.	PUNCT
hjic-87	303	1	henriksen	henriksen	PROPN
hjic-87	303	2	i.	i.	PROPN
hjic-87	303	3	b.	b.	PROPN
hjic-87	303	4	,	,	PUNCT
hjic-87	303	5	mishra	mishra	PROPN
hjic-87	303	6	a.	a.	PROPN
hjic-87	303	7	k.	k.	PROPN
hjic-87	303	8	,	,	PUNCT
hjic-87	303	9	pace	pace	NOUN
hjic-87	303	10	g.	g.	PROPN
hjic-87	303	11	w.	w.	PROPN
hjic-87	303	12	,	,	PUNCT
hjic-87	303	13	johnston	johnston	PROPN
hjic-87	303	14	k.	k.	PROPN
hjic-87	303	15	p.	p.	PROPN
hjic-87	303	16	and	and	CCONJ
hjic-87	303	17	mawson	mawson	PROPN
hjic-87	303	18	s.	s.	PROPN
hjic-87	303	19	:	:	PUNCT
hjic-87	303	20	wo	will	AUX
hjic-87	303	21	pat	pat	PROPN
hjic-87	303	22	.	.	PROPN
hjic-87	304	1	97/14407	97/14407	NUM
hjic-87	304	2	(	(	PUNCT
hjic-87	304	3	1997	1997	NUM
hjic-87	304	4	)	)	PUNCT
hjic-87	304	5	54	54	NUM
hjic-87	304	6	14	14	NUM
hjic-87	304	7	.	.	PUNCT
hjic-87	305	1	young	young	ADJ
hjic-87	305	2	t.	t.	PROPN
hjic-87	305	3	j.	j.	PROPN
hjic-87	305	4	,	,	PUNCT
hjic-87	305	5	mawson	mawson	PROPN
hjic-87	305	6	s.	s.	PROPN
hjic-87	305	7	,	,	PUNCT
hjic-87	305	8	johnston	johnston	PROPN
hjic-87	305	9	p.	p.	PROPN
hjic-87	305	10	,	,	PUNCT
hjic-87	305	11	henriksen	henriksen	PROPN
hjic-87	305	12	i.	i.	PROPN
hjic-87	305	13	b.	b.	PROPN
hjic-87	305	14	,	,	PUNCT
hjic-87	305	15	pace	pace	NOUN
hjic-87	305	16	g.	g.	PROPN
hjic-87	305	17	w.	w.	PROPN
hjic-87	305	18	and	and	CCONJ
hjic-87	305	19	mishra	mishra	PROPN
hjic-87	305	20	a.	a.	PROPN
hjic-87	305	21	k.	k.	PROPN
hjic-87	305	22	:	:	PUNCT
hjic-87	305	23	biotechnol	biotechnol	PROPN
hjic-87	305	24	.	.	PUNCT
hjic-87	306	1	prog	prog	PROPN
hjic-87	306	2	.	.	PROPN
hjic-87	306	3	,	,	PUNCT
hjic-87	307	1	2000	2000	NUM
hjic-87	307	2	,	,	PUNCT
hjic-87	307	3	16	16	NUM
hjic-87	307	4	,	,	PUNCT
hjic-87	307	5	402	402	NUM
hjic-87	307	6	-	-	SYM
hjic-87	307	7	407	407	NUM
hjic-87	307	8	15	15	NUM
hjic-87	307	9	.	.	PUNCT
hjic-87	308	1	godinas	godinas	PROPN
hjic-87	308	2	a.	a.	PROPN
hjic-87	308	3	,	,	PUNCT
hjic-87	308	4	henriksen	henriksen	PROPN
hjic-87	308	5	i.	i.	PROPN
hjic-87	308	6	b.	b.	PROPN
hjic-87	308	7	,	,	PUNCT
hjic-87	308	8	krukonis	krukonis	PROPN
hjic-87	308	9	v.	v.	PROPN
hjic-87	308	10	,	,	PUNCT
hjic-87	308	11	mishra	mishra	PROPN
hjic-87	308	12	k.	k.	PROPN
hjic-87	308	13	a.	a.	PROPN
hjic-87	308	14	,	,	PUNCT
hjic-87	308	15	pace	pace	NOUN
hjic-87	308	16	g.	g.	PROPN
hjic-87	308	17	w.	w.	PROPN
hjic-87	308	18	and	and	CCONJ
hjic-87	308	19	vachon	vachon	PROPN
hjic-87	308	20	g.	g.	PROPN
hjic-87	308	21	m.	m.	PROPN
hjic-87	308	22	:	:	PUNCT
hjic-87	308	23	wo	will	AUX
hjic-87	308	24	pat	pat	PROPN
hjic-87	308	25	.	.	PROPN
hjic-87	308	26	99/65469	99/65469	NUM
hjic-87	308	27	(	(	PUNCT
hjic-87	308	28	1996	1996	NUM
hjic-87	308	29	)	)	PUNCT
hjic-87	308	30	16	16	NUM
hjic-87	308	31	.	.	PUNCT
hjic-87	309	1	bausch	bausch	PROPN
hjic-87	309	2	a.	a.	PROPN
hjic-87	309	3	and	and	CCONJ
hjic-87	309	4	hidber	hidber	PROPN
hjic-87	309	5	p.	p.	NOUN
hjic-87	309	6	:	:	PUNCT
hjic-87	309	7	wo	will	AUX
hjic-87	309	8	pat	pat	PROPN
hjic-87	309	9	.	.	PROPN
hjic-87	310	1	99/52504	99/52504	NUM
hjic-87	310	2	(	(	PUNCT
hjic-87	310	3	1999	1999	NUM
hjic-87	310	4	)	)	PUNCT
hjic-87	310	5	17	17	NUM
hjic-87	310	6	.	.	PUNCT
hjic-87	311	1	debenedetti	debenedetti	PROPN
hjic-87	311	2	p.	p.	PROPN
hjic-87	311	3	g.	g.	PROPN
hjic-87	311	4	,	,	PUNCT
hjic-87	311	5	tom	tom	PROPN
hjic-87	311	6	j.	j.	PROPN
hjic-87	311	7	w.	w.	PROPN
hjic-87	311	8	,	,	PUNCT
hjic-87	311	9	yeo	yeo	PROPN
hjic-87	311	10	s.d	s.d	PROPN
hjic-87	311	11	.	.	PROPN
hjic-87	312	1	and	and	CCONJ
hjic-87	312	2	lim	lim	PROPN
hjic-87	312	3	g.b	g.b	PROPN
hjic-87	312	4	.	.	PROPN
hjic-87	312	5	:	:	PUNCT
hjic-87	313	1	journal	journal	PROPN
hjic-87	313	2	of	of	ADP
hjic-87	313	3	controlled	control	VERB
hjic-87	313	4	release	release	NOUN
hjic-87	313	5	,	,	PUNCT
hjic-87	313	6	1993	1993	NUM
hjic-87	313	7	,	,	PUNCT
hjic-87	313	8	24	24	NUM
hjic-87	313	9	,	,	PUNCT
hjic-87	313	10	2744	2744	NUM
hjic-87	313	11	18	18	NUM
hjic-87	313	12	.	.	PUNCT
hjic-87	314	1	debenedetti	debenedetti	PROPN
hjic-87	314	2	p.	p.	PROPN
hjic-87	314	3	g.	g.	PROPN
hjic-87	314	4	,	,	PUNCT
hjic-87	314	5	tom	tom	PROPN
hjic-87	314	6	j.	j.	PROPN
hjic-87	314	7	w.	w.	PROPN
hjic-87	314	8	,	,	PUNCT
hjic-87	314	9	and	and	CCONJ
hjic-87	314	10	jerome	jerome	PROPN
hjic-87	314	11	r.	r.	PROPN
hjic-87	314	12	:	:	PUNCT
hjic-87	314	13	journal	journal	NOUN
hjic-87	314	14	of	of	ADP
hjic-87	314	15	supercritical	supercritical	ADJ
hjic-87	314	16	fluids	fluid	NOUN
hjic-87	314	17	,	,	PUNCT
hjic-87	314	18	1994	1994	NUM
hjic-87	314	19	,	,	PUNCT
hjic-87	314	20	7	7	NUM
hjic-87	314	21	,	,	PUNCT
hjic-87	314	22	1	1	NUM
hjic-87	314	23	,	,	PUNCT
hjic-87	314	24	9	9	NUM
hjic-87	314	25	-	-	SYM
hjic-87	314	26	29	29	NUM
hjic-87	314	27	19	19	NUM
hjic-87	314	28	.	.	PUNCT
hjic-87	315	1	kim	kim	PROPN
hjic-87	315	2	j.	j.	PROPN
hjic-87	315	3	,	,	PUNCT
hjic-87	315	4	paxton	paxton	PROPN
hjic-87	315	5	t.	t.	PROPN
hjic-87	315	6	and	and	CCONJ
hjic-87	315	7	tomasko	tomasko	PROPN
hjic-87	315	8	d.	d.	PROPN
hjic-87	315	9	:	:	PUNCT
hjic-87	315	10	biotech	biotech	PROPN
hjic-87	315	11	.	.	PUNCT
hjic-87	315	12	prog	prog	PROPN
hjic-87	315	13	.	.	PROPN
hjic-87	315	14	,	,	PUNCT
hjic-87	315	15	1996	1996	NUM
hjic-87	315	16	,	,	PUNCT
hjic-87	315	17	12	12	NUM
hjic-87	315	18	,	,	PUNCT
hjic-87	315	19	650661	650661	NUM
hjic-87	315	20	20	20	NUM
hjic-87	315	21	.	.	PUNCT
hjic-87	316	1	ye	ye	PRON
hjic-87	316	2	c.	c.	PROPN
hjic-87	316	3	:	:	PUNCT
hjic-87	316	4	enhanced	enhance	VERB
hjic-87	316	5	dissolution	dissolution	NOUN
hjic-87	316	6	of	of	ADP
hjic-87	316	7	relatively	relatively	ADV
hjic-87	316	8	insoluble	insoluble	ADJ
hjic-87	316	9	drugs	drug	NOUN
hjic-87	316	10	from	from	ADP
hjic-87	316	11	small	small	ADJ
hjic-87	316	12	particles	particle	NOUN
hjic-87	316	13	and	and	CCONJ
hjic-87	316	14	solid	solid	ADJ
hjic-87	316	15	dispersions	dispersion	NOUN
hjic-87	316	16	formed	form	VERB
hjic-87	316	17	from	from	ADP
hjic-87	316	18	supercritical	supercritical	ADJ
hjic-87	316	19	solutions	solution	NOUN
hjic-87	316	20	.	.	PUNCT
hjic-87	317	1	ph.d	ph.d	PROPN
hjic-87	317	2	.	.	PUNCT
hjic-87	318	1	thesis	thesis	PROPN
hjic-87	318	2	,	,	PUNCT
hjic-87	318	3	ohio	ohio	PROPN
hjic-87	318	4	state	state	PROPN
hjic-87	318	5	university	university	PROPN
hjic-87	318	6	,	,	PUNCT
hjic-87	318	7	usa	usa	PROPN
hjic-87	318	8	,	,	PUNCT
hjic-87	318	9	2000	2000	NUM
hjic-87	318	10	21	21	NUM
hjic-87	318	11	.	.	PUNCT
hjic-87	319	1	weidner	weidner	PROPN
hjic-87	319	2	e.	e.	PROPN
hjic-87	319	3	,	,	PUNCT
hjic-87	319	4	knez	knez	PROPN
hjic-87	319	5	z.	z.	PROPN
hjic-87	319	6	and	and	CCONJ
hjic-87	319	7	novak	novak	PROPN
hjic-87	319	8	z.	z.	PROPN
hjic-87	319	9	:	:	PUNCT
hjic-87	319	10	wo	will	AUX
hjic-87	319	11	pat	pat	PROPN
hjic-87	319	12	.	.	PROPN
hjic-87	320	1	95/21688	95/21688	NUM
hjic-87	320	2	(	(	PUNCT
hjic-87	320	3	1995	1995	NUM
hjic-87	320	4	)	)	PUNCT
hjic-87	320	5	22	22	NUM
hjic-87	320	6	.	.	PUNCT
hjic-87	321	1	nielsen	nielsen	PROPN
hjic-87	321	2	k.	k.	PROPN
hjic-87	321	3	a.	a.	PROPN
hjic-87	321	4	,	,	PUNCT
hjic-87	321	5	bok	bok	PROPN
hjic-87	321	6	h.	h.	PROPN
hjic-87	321	7	f.	f.	PROPN
hjic-87	321	8	and	and	CCONJ
hjic-87	321	9	hoy	hoy	PROPN
hjic-87	321	10	k.	k.	PROPN
hjic-87	321	11	l.	l.	PROPN
hjic-87	321	12	:	:	PUNCT
hjic-87	322	1	u.s	u.s	PROPN
hjic-87	322	2	.	.	PROPN
hjic-87	322	3	pat	pat	PROPN
hjic-87	322	4	.	.	PROPN
hjic-87	322	5	5,057,342	5,057,342	NUM
hjic-87	322	6	(	(	PUNCT
hjic-87	322	7	1989	1989	NUM
hjic-87	322	8	)	)	PUNCT
hjic-87	322	9	23	23	NUM
hjic-87	322	10	.	.	PUNCT
hjic-87	323	1	sievers	sievers	PROPN
hjic-87	323	2	r.	r.	PROPN
hjic-87	323	3	e.	e.	PROPN
hjic-87	323	4	and	and	CCONJ
hjic-87	323	5	karst	karst	PROPN
hjic-87	323	6	u.	u.	PROPN
hjic-87	323	7	:	:	PUNCT
hjic-87	323	8	ep	ep	PROPN
hjic-87	323	9	pat	pat	PROPN
hjic-87	323	10	.	.	PROPN
hjic-87	323	11	0,677,332	0,677,332	NUM
hjic-87	323	12	(	(	PUNCT
hjic-87	323	13	1995	1995	NUM
hjic-87	323	14	)	)	PUNCT
hjic-87	323	15	24	24	NUM
hjic-87	323	16	.	.	PUNCT
hjic-87	324	1	shine	shine	NOUN
hjic-87	324	2	a.	a.	PROPN
hjic-87	324	3	and	and	CCONJ
hjic-87	324	4	gelb	gelb	PROPN
hjic-87	324	5	j.	j.	PROPN
hjic-87	324	6	:	:	PUNCT
hjic-87	324	7	wo	will	AUX
hjic-87	324	8	pat	pat	PROPN
hjic-87	324	9	.	.	PROPN
hjic-87	325	1	98/15348	98/15348	NUM
hjic-87	325	2	(	(	PUNCT
hjic-87	325	3	1998	1998	NUM
hjic-87	325	4	)	)	PUNCT
hjic-87	325	5	25	25	NUM
hjic-87	325	6	.	.	PUNCT
hjic-87	326	1	shakesheff	shakesheff	PROPN
hjic-87	326	2	k.	k.	PROPN
hjic-87	326	3	m.	m.	PROPN
hjic-87	326	4	,	,	PUNCT
hjic-87	326	5	watson	watson	PROPN
hjic-87	326	6	m.	m.	PROPN
hjic-87	326	7	s.	s.	PROPN
hjic-87	326	8	,	,	PUNCT
hjic-87	326	9	whitaker	whitaker	PROPN
hjic-87	326	10	m.	m.	PROPN
hjic-87	326	11	j.	j.	PROPN
hjic-87	326	12	and	and	CCONJ
hjic-87	326	13	howdle	howdle	PROPN
hjic-87	326	14	s.	s.	PROPN
hjic-87	326	15	m.	m.	PROPN
hjic-87	326	16	:	:	PUNCT
hjic-87	326	17	wo	will	AUX
hjic-87	326	18	pat	pat	PROPN
hjic-87	326	19	.	.	PROPN
hjic-87	327	1	03/078508	03/078508	PROPN
hjic-87	327	2	(	(	PUNCT
hjic-87	327	3	2003	2003	NUM
hjic-87	327	4	)	)	PUNCT
hjic-87	327	5	26	26	NUM
hjic-87	327	6	.	.	PUNCT
hjic-87	328	1	salem	salem	PROPN
hjic-87	328	2	a.	a.	PROPN
hjic-87	328	3	k.	k.	PROPN
hjic-87	328	4	,	,	PUNCT
hjic-87	328	5	rose	rise	VERB
hjic-87	328	6	f.	f.	PROPN
hjic-87	328	7	r.	r.	PROPN
hjic-87	328	8	a.	a.	PROPN
hjic-87	328	9	j.	j.	PROPN
hjic-87	328	10	,	,	PUNCT
hjic-87	328	11	oreffo	oreffo	PROPN
hjic-87	328	12	r.	r.	PROPN
hjic-87	328	13	o.	o.	PROPN
hjic-87	328	14	c.	c.	PROPN
hjic-87	328	15	,	,	PUNCT
hjic-87	328	16	yang	yang	PROPN
hjic-87	328	17	x.	x.	PROPN
hjic-87	328	18	b.	b.	PROPN
hjic-87	328	19	,	,	PUNCT
hjic-87	328	20	davies	davies	PROPN
hjic-87	328	21	m.	m.	PROPN
hjic-87	328	22	c.	c.	PROPN
hjic-87	328	23	,	,	PUNCT
hjic-87	328	24	mitchell	mitchell	PROPN
hjic-87	328	25	j.	j.	PROPN
hjic-87	328	26	r.	r.	PROPN
hjic-87	328	27	,	,	PUNCT
hjic-87	328	28	roberts	roberts	PROPN
hjic-87	328	29	c.	c.	PROPN
hjic-87	328	30	j.	j.	PROPN
hjic-87	328	31	,	,	PUNCT
hjic-87	328	32	stolnik	stolnik	PROPN
hjic-87	328	33	-	-	PUNCT
hjic-87	328	34	trenkic	trenkic	PROPN
hjic-87	328	35	s.	s.	PROPN
hjic-87	328	36	,	,	PUNCT
hjic-87	328	37	tendler	tendler	PROPN
hjic-87	328	38	s.	s.	PROPN
hjic-87	328	39	j.	j.	PROPN
hjic-87	328	40	b.	b.	PROPN
hjic-87	328	41	,	,	PUNCT
hjic-87	328	42	williams	williams	PROPN
hjic-87	328	43	p.	p.	PROPN
hjic-87	328	44	m.	m.	NOUN
hjic-87	328	45	and	and	CCONJ
hjic-87	328	46	shakesheff	shakesheff	PROPN
hjic-87	328	47	k.	k.	PROPN
hjic-87	328	48	m.	m.	PROPN
hjic-87	328	49	:	:	PUNCT
hjic-87	328	50	adv	adv	PROPN
hjic-87	328	51	.	.	PUNCT
hjic-87	328	52	mater	mater	PROPN
hjic-87	328	53	.	.	PUNCT
hjic-87	328	54	2003	2003	NUM
hjic-87	328	55	,	,	PUNCT
hjic-87	328	56	15	15	NUM
hjic-87	328	57	,	,	PUNCT
hjic-87	328	58	210	210	NUM
hjic-87	328	59	221	221	NUM
hjic-87	328	60	27	27	NUM
hjic-87	328	61	.	.	PUNCT
hjic-87	329	1	whitaker	whitaker	PROPN
hjic-87	329	2	m.	m.	PROPN
hjic-87	329	3	j.	j.	PROPN
hjic-87	329	4	,	,	PUNCT
hjic-87	329	5	hao	hao	PROPN
hjic-87	329	6	j.	j.	PROPN
hjic-87	329	7	,	,	PUNCT
hjic-87	329	8	davies	davies	PROPN
hjic-87	329	9	o.	o.	PROPN
hjic-87	329	10	r.	r.	PROPN
hjic-87	329	11	,	,	PUNCT
hjic-87	329	12	serhatkulu	serhatkulu	ADJ
hjic-87	329	13	g.	g.	NOUN
hjic-87	329	14	,	,	PUNCT
hjic-87	329	15	stolnik	stolnik	PROPN
hjic-87	329	16	-	-	PUNCT
hjic-87	329	17	trenkic	trenkic	PROPN
hjic-87	329	18	s.	s.	PROPN
hjic-87	329	19	,	,	PUNCT
hjic-87	329	20	howdle	howdle	PROPN
hjic-87	329	21	s.	s.	PROPN
hjic-87	329	22	m.	m.	PROPN
hjic-87	329	23	and	and	CCONJ
hjic-87	329	24	shakesheff	shakesheff	VERB
hjic-87	329	25	k.m	k.m	PROPN
hjic-87	329	26	.	.	PROPN
hjic-87	329	27	:	:	PUNCT
hjic-87	330	1	j.	j.	PROPN
hjic-87	330	2	controlled	control	VERB
hjic-87	330	3	release	release	NOUN
hjic-87	330	4	,	,	PUNCT
hjic-87	330	5	2004	2004	NUM
hjic-87	330	6	,	,	PUNCT
hjic-87	330	7	in	in	ADP
hjic-87	330	8	press	press	NOUN
hjic-87	330	9	28	28	NUM
hjic-87	330	10	.	.	PUNCT
hjic-87	331	1	watson	watson	PROPN
hjic-87	331	2	m.	m.	PROPN
hjic-87	331	3	s.	s.	PROPN
hjic-87	331	4	,	,	PUNCT
hjic-87	331	5	whitaker	whitaker	PROPN
hjic-87	331	6	m.	m.	PROPN
hjic-87	331	7	j.	j.	PROPN
hjic-87	331	8	and	and	CCONJ
hjic-87	331	9	howdle	howdle	PROPN
hjic-87	331	10	s.	s.	PROPN
hjic-87	331	11	m.	m.	PROPN
hjic-87	331	12	:	:	PUNCT
hjic-87	331	13	adv	adv	PROPN
hjic-87	331	14	.	.	PUNCT
hjic-87	331	15	mater	mater	PROPN
hjic-87	331	16	.	.	PUNCT
hjic-87	331	17	2002	2002	NUM
hjic-87	331	18	,	,	PUNCT
hjic-87	331	19	14(24	14(24	NUM
hjic-87	331	20	)	)	PUNCT
hjic-87	331	21	,	,	PUNCT
hjic-87	331	22	1802	1802	NUM
hjic-87	331	23	-	-	SYM
hjic-87	331	24	1804	1804	NUM
hjic-87	331	25	29	29	NUM
hjic-87	331	26	.	.	PUNCT
hjic-87	332	1	kerc	kerc	PROPN
hjic-87	332	2	j.	j.	PROPN
hjic-87	332	3	,	,	PUNCT
hjic-87	332	4	srcic	srcic	PROPN
hjic-87	332	5	s.	s.	PROPN
hjic-87	332	6	,	,	PUNCT
hjic-87	332	7	knez	knez	PROPN
hjic-87	332	8	z.	z.	PROPN
hjic-87	332	9	and	and	CCONJ
hjic-87	332	10	sencar	sencar	ADJ
hjic-87	332	11	-	-	PUNCT
hjic-87	332	12	bozic	bozic	NOUN
hjic-87	332	13	p.	p.	NOUN
hjic-87	332	14	:	:	PUNCT
hjic-87	333	1	int	int	NOUN
hjic-87	333	2	.	.	PUNCT
hjic-87	334	1	j.	j.	PROPN
hjic-87	334	2	pharm	pharm	PROPN
hjic-87	334	3	.	.	PUNCT
hjic-87	334	4	,	,	PUNCT
hjic-87	334	5	1999	1999	NUM
hjic-87	334	6	,	,	PUNCT
hjic-87	334	7	182	182	NUM
hjic-87	334	8	,	,	PUNCT
hjic-87	334	9	33	33	NUM
hjic-87	334	10	-	-	SYM
hjic-87	334	11	39	39	NUM
hjic-87	334	12	30	30	NUM
hjic-87	334	13	.	.	PUNCT
hjic-87	335	1	sencar	sencar	NOUN
hjic-87	335	2	-	-	PUNCT
hjic-87	335	3	bozic	bozic	NOUN
hjic-87	335	4	p.	p.	NOUN
hjic-87	335	5	,	,	PUNCT
hjic-87	335	6	srcic	srcic	PROPN
hjic-87	335	7	s.	s.	PROPN
hjic-87	335	8	,	,	PUNCT
hjic-87	335	9	knez	knez	PROPN
hjic-87	335	10	z.	z.	PROPN
hjic-87	335	11	and	and	CCONJ
hjic-87	335	12	kerc	kerc	PROPN
hjic-87	335	13	j.	j.	PROPN
hjic-87	335	14	:	:	PUNCT
hjic-87	335	15	int	int	PROPN
hjic-87	335	16	.	.	PUNCT
hjic-87	336	1	j.	j.	PROPN
hjic-87	336	2	pharm	pharm	PROPN
hjic-87	336	3	.	.	PUNCT
hjic-87	336	4	,	,	PUNCT
hjic-87	336	5	1997	1997	NUM
hjic-87	336	6	,	,	PUNCT
hjic-87	336	7	148	148	NUM
hjic-87	336	8	,	,	PUNCT
hjic-87	336	9	123	123	NUM
hjic-87	336	10	-	-	SYM
hjic-87	336	11	130	130	NUM
hjic-87	336	12	31	31	NUM
hjic-87	336	13	.	.	PUNCT
hjic-87	337	1	rodrigues	rodrigues	PROPN
hjic-87	337	2	m.	m.	PROPN
hjic-87	337	3	,	,	PUNCT
hjic-87	337	4	peirico	peirico	PROPN
hjic-87	337	5	n.	n.	PROPN
hjic-87	337	6	,	,	PUNCT
hjic-87	337	7	matos	matos	PROPN
hjic-87	337	8	h.	h.	PROPN
hjic-87	337	9	,	,	PUNCT
hjic-87	337	10	gomes	gomes	PROPN
hjic-87	337	11	de	de	PROPN
hjic-87	337	12	azevedo	azevedo	PROPN
hjic-87	337	13	e.	e.	PROPN
hjic-87	337	14	,	,	PUNCT
hjic-87	337	15	lobarto	lobarto	PROPN
hjic-87	337	16	m.	m.	PROPN
hjic-87	337	17	r.	r.	PROPN
hjic-87	337	18	v	v	PROPN
hjic-87	337	19	almeida	almeida	PROPN
hjic-87	337	20	a.	a.	PROPN
hjic-87	337	21	j.	j.	PROPN
hjic-87	337	22	:	:	PUNCT
hjic-87	337	23	j.	j.	PROPN
hjic-87	337	24	supercrit	supercrit	PROPN
hjic-87	337	25	.	.	PUNCT
hjic-87	337	26	fluids	fluid	NOUN
hjic-87	337	27	,	,	PUNCT
hjic-87	337	28	2004	2004	NUM
hjic-87	337	29	,	,	PUNCT
hjic-87	337	30	29	29	NUM
hjic-87	337	31	,	,	PUNCT
hjic-87	337	32	175	175	NUM
hjic-87	337	33	-	-	SYM
hjic-87	337	34	184	184	NUM
hjic-87	337	35	32	32	NUM
hjic-87	337	36	.	.	PUNCT
hjic-87	338	1	krukonis	krukonis	PROPN
hjic-87	338	2	v.j	v.j	PROPN
hjic-87	338	3	.	.	PROPN
hjic-87	338	4	,	,	PUNCT
hjic-87	338	5	gallagher	gallagher	PROPN
hjic-87	338	6	p.	p.	PROPN
hjic-87	338	7	m.	m.	NOUN
hjic-87	338	8	and	and	CCONJ
hjic-87	339	1	coffey	coffey	PROPN
hjic-87	339	2	m.	m.	NOUN
hjic-87	339	3	p.	p.	PROPN
hjic-87	339	4	:	:	PUNCT
hjic-87	340	1	u.s	u.s	PROPN
hjic-87	340	2	.	.	PROPN
hjic-87	340	3	pat	pat	PROPN
hjic-87	340	4	.	.	PROPN
hjic-87	341	1	5,360,478	5,360,478	NUM
hjic-87	341	2	(	(	PUNCT
hjic-87	341	3	1994	1994	NUM
hjic-87	341	4	)	)	PUNCT
hjic-87	341	5	33	33	NUM
hjic-87	341	6	.	.	PUNCT
hjic-87	342	1	pallado	pallado	PROPN
hjic-87	342	2	p.	p.	PROPN
hjic-87	342	3	,	,	PUNCT
hjic-87	342	4	benedetti	benedetti	PROPN
hjic-87	342	5	l.	l.	PROPN
hjic-87	342	6	and	and	CCONJ
hjic-87	342	7	callegaro	callegaro	PROPN
hjic-87	342	8	l.	l.	PROPN
hjic-87	342	9	:	:	PUNCT
hjic-87	342	10	wo	will	AUX
hjic-87	342	11	pat	pat	PROPN
hjic-87	342	12	.	.	PUNCT
hjic-87	343	1	96/29998	96/29998	NUM
hjic-87	343	2	(	(	PUNCT
hjic-87	343	3	1996	1996	NUM
hjic-87	343	4	)	)	PUNCT
hjic-87	344	1	34	34	NUM
hjic-87	344	2	.	.	PUNCT
hjic-87	344	3	moneghini	moneghini	PROPN
hjic-87	344	4	m.	m.	PROPN
hjic-87	344	5	,	,	PUNCT
hjic-87	344	6	kikic	kikic	PROPN
hjic-87	344	7	i.	i.	PROPN
hjic-87	344	8	,	,	PUNCT
hjic-87	344	9	voinovich	voinovich	PROPN
hjic-87	344	10	d.	d.	PROPN
hjic-87	344	11	,	,	PUNCT
hjic-87	344	12	perissutti	perissutti	PROPN
hjic-87	344	13	b.	b.	PROPN
hjic-87	344	14	and	and	CCONJ
hjic-87	344	15	filipovic	filipovic	PROPN
hjic-87	344	16	-	-	PUNCT
hjic-87	344	17	grcic	grcic	PROPN
hjic-87	344	18	j.	j.	PROPN
hjic-87	344	19	:	:	PUNCT
hjic-87	344	20	int	int	PROPN
hjic-87	344	21	.	.	PUNCT
hjic-87	345	1	j.	j.	PROPN
hjic-87	345	2	pharm	pharm	PROPN
hjic-87	345	3	.	.	PROPN
hjic-87	345	4	,	,	PUNCT
hjic-87	345	5	2001	2001	NUM
hjic-87	345	6	,	,	PUNCT
hjic-87	345	7	222	222	NUM
hjic-87	345	8	,	,	PUNCT
hjic-87	345	9	129	129	NUM
hjic-87	345	10	-	-	SYM
hjic-87	345	11	138	138	NUM
hjic-87	345	12	35	35	NUM
hjic-87	345	13	.	.	PUNCT
hjic-87	346	1	bertucco	bertucco	PROPN
hjic-87	346	2	a.	a.	PROPN
hjic-87	346	3	,	,	PUNCT
hjic-87	346	4	vaccaro	vaccaro	PROPN
hjic-87	346	5	f.	f.	PROPN
hjic-87	346	6	and	and	CCONJ
hjic-87	346	7	pallado	pallado	PROPN
hjic-87	346	8	p.	p.	NOUN
hjic-87	346	9	:	:	PUNCT
hjic-87	347	1	drugs	drug	NOUN
hjic-87	347	2	encapsulation	encapsulation	NOUN
hjic-87	347	3	using	use	VERB
hjic-87	347	4	a	a	DET
hjic-87	347	5	compressed	compress	VERB
hjic-87	347	6	gas	gas	NOUN
hjic-87	347	7	antislvent	antislvent	NOUN
hjic-87	347	8	precipitation	precipitation	NOUN
hjic-87	347	9	,	,	PUNCT
hjic-87	347	10	4th	4th	ADJ
hjic-87	347	11	italian	italian	ADJ
hjic-87	347	12	conference	conference	NOUN
hjic-87	347	13	on	on	ADP
hjic-87	347	14	supercritical	supercritical	ADJ
hjic-87	347	15	fluids	fluid	NOUN
hjic-87	347	16	and	and	CCONJ
hjic-87	347	17	their	their	PRON
hjic-87	347	18	applications	application	NOUN
hjic-87	347	19	,	,	PUNCT
hjic-87	347	20	cves	cf	NOUN
hjic-87	347	21	,	,	PUNCT
hjic-87	347	22	salermo	salermo	NOUN
hjic-87	347	23	1997	1997	NUM
hjic-87	347	24	i	i	NOUN
hjic-87	347	25	,	,	PUNCT
hjic-87	347	26	327	327	NUM
hjic-87	347	27	36	36	NUM
hjic-87	347	28	.	.	PUNCT
hjic-87	348	1	bertucco	bertucco	PROPN
hjic-87	348	2	a.	a.	PROPN
hjic-87	348	3	,	,	PUNCT
hjic-87	348	4	pallado	pallado	PROPN
hjic-87	348	5	p.	p.	NOUN
hjic-87	348	6	and	and	CCONJ
hjic-87	348	7	benedetti	benedetti	PROPN
hjic-87	348	8	l.	l.	PROPN
hjic-87	348	9	:	:	PUNCT
hjic-87	348	10	proceedings	proceeding	NOUN
hjic-87	348	11	of	of	ADP
hjic-87	348	12	high	high	ADJ
hjic-87	348	13	pres	pres	PROPN
hjic-87	348	14	.	.	PUNCT
hjic-87	349	1	chem	chem	PROPN
hjic-87	349	2	.	.	PUNCT
hjic-87	350	1	eng	eng	PROPN
hjic-87	350	2	.	.	PROPN
hjic-87	350	3	,	,	PUNCT
hjic-87	350	4	elsevier	elsevier	NOUN
hjic-87	350	5	,	,	PUNCT
hjic-87	350	6	1996	1996	NUM
hjic-87	350	7	,	,	PUNCT
hjic-87	350	8	217	217	NUM
hjic-87	350	9	-	-	SYM
hjic-87	350	10	222	222	NUM
hjic-87	350	11	37	37	NUM
hjic-87	350	12	.	.	PUNCT
hjic-87	351	1	kikic	kikic	PROPN
hjic-87	351	2	i.	i.	PROPN
hjic-87	351	3	,	,	PUNCT
hjic-87	351	4	alessi	alessi	PROPN
hjic-87	351	5	p.	p.	PROPN
hjic-87	351	6	,	,	PUNCT
hjic-87	351	7	cortesi	cortesi	PROPN
hjic-87	351	8	a.	a.	PROPN
hjic-87	351	9	,	,	PUNCT
hjic-87	351	10	eva	eva	PROPN
hjic-87	351	11	f.	f.	PROPN
hjic-87	351	12	,	,	PUNCT
hjic-87	351	13	moneghini	moneghini	NOUN
hjic-87	351	14	m.	m.	NOUN
hjic-87	351	15	,	,	PUNCT
hjic-87	351	16	perissutti	perissutti	PROPN
hjic-87	351	17	b.	b.	PROPN
hjic-87	351	18	and	and	CCONJ
hjic-87	351	19	voinovich	voinovich	PROPN
hjic-87	351	20	d.	d.	PROPN
hjic-87	351	21	:	:	PUNCT
hjic-87	351	22	supercritical	supercritical	ADJ
hjic-87	351	23	antisolvent	antisolvent	ADJ
hjic-87	351	24	precipitation	precipitation	NOUN
hjic-87	351	25	processes	process	NOUN
hjic-87	351	26	:	:	PUNCT
hjic-87	351	27	different	different	ADJ
hjic-87	351	28	ways	way	NOUN
hjic-87	351	29	for	for	ADP
hjic-87	351	30	impoving	impove	VERB
hjic-87	351	31	the	the	DET
hjic-87	351	32	performance	performance	NOUN
hjic-87	351	33	of	of	ADP
hjic-87	351	34	drugs	drug	NOUN
hjic-87	351	35	,	,	PUNCT
hjic-87	351	36	4th	4th	ADJ
hjic-87	351	37	international	international	ADJ
hjic-87	351	38	symposium	symposium	NOUN
hjic-87	351	39	on	on	ADP
hjic-87	351	40	high	high	ADJ
hjic-87	351	41	pressure	pressure	NOUN
hjic-87	351	42	process	process	NOUN
hjic-87	351	43	technology	technology	NOUN
hjic-87	351	44	and	and	CCONJ
hjic-87	351	45	chemical	chemical	NOUN
hjic-87	351	46	engineering	engineering	NOUN
hjic-87	351	47	,	,	PUNCT
hjic-87	351	48	venice	venice	PROPN
hjic-87	351	49	(	(	PUNCT
hjic-87	351	50	italy	italy	PROPN
hjic-87	351	51	)	)	PUNCT
hjic-87	351	52	22	22	NUM
hjic-87	351	53	-	-	SYM
hjic-87	351	54	25	25	NUM
hjic-87	351	55	september	september	PROPN
hjic-87	351	56	,	,	PUNCT
hjic-87	351	57	2002	2002	NUM
hjic-87	351	58	38	38	NUM
hjic-87	351	59	.	.	PUNCT
hjic-87	352	1	sethia	sethia	PROPN
hjic-87	352	2	s.	s.	PROPN
hjic-87	352	3	and	and	CCONJ
hjic-87	352	4	squillante	squillante	PROPN
hjic-87	352	5	e.	e.	PROPN
hjic-87	352	6	:	:	PUNCT
hjic-87	352	7	j.	j.	PROPN
hjic-87	352	8	of	of	ADP
hjic-87	352	9	pharm	pharm	PROPN
hjic-87	352	10	.	.	PUNCT
hjic-87	353	1	sci	sci	PROPN
hjic-87	353	2	.	.	PROPN
hjic-87	353	3	,	,	PUNCT
hjic-87	353	4	2002	2002	NUM
hjic-87	353	5	,	,	PUNCT
hjic-87	353	6	91	91	NUM
hjic-87	353	7	,	,	PUNCT
hjic-87	353	8	1948	1948	NUM
hjic-87	353	9	-	-	SYM
hjic-87	353	10	1957	1957	NUM
hjic-87	353	11	39	39	NUM
hjic-87	353	12	.	.	PUNCT
hjic-87	354	1	sethia	sethia	PROPN
hjic-87	354	2	s.	s.	PROPN
hjic-87	354	3	and	and	CCONJ
hjic-87	354	4	squillante	squillante	PROPN
hjic-87	354	5	e.	e.	PROPN
hjic-87	354	6	:	:	PUNCT
hjic-87	354	7	int	int	PROPN
hjic-87	354	8	.	.	PUNCT
hjic-87	355	1	j.	j.	PROPN
hjic-87	355	2	of	of	ADP
hjic-87	355	3	pharm	pharm	PROPN
hjic-87	355	4	.	.	PUNCT
hjic-87	355	5	,	,	PUNCT
hjic-87	355	6	2004	2004	NUM
hjic-87	355	7	,	,	PUNCT
hjic-87	355	8	272	272	NUM
hjic-87	355	9	,	,	PUNCT
hjic-87	355	10	1	1	NUM
hjic-87	355	11	-	-	SYM
hjic-87	355	12	10	10	NUM
hjic-87	355	13	40	40	NUM
hjic-87	355	14	.	.	PUNCT
hjic-87	356	1	fischer	fischer	PROPN
hjic-87	356	2	w.	w.	PROPN
hjic-87	356	3	and	and	CCONJ
hjic-87	356	4	müller	müller	PROPN
hjic-87	356	5	b.	b.	PROPN
hjic-87	356	6	w.	w.	PROPN
hjic-87	356	7	:	:	PUNCT
hjic-87	356	8	u.s	u.s	PROPN
hjic-87	356	9	.	.	PROPN
hjic-87	356	10	pat	pat	PROPN
hjic-87	356	11	.	.	PROPN
hjic-87	356	12	5,043,280	5,043,280	NUM
hjic-87	356	13	(	(	PUNCT
hjic-87	356	14	1991	1991	NUM
hjic-87	356	15	)	)	PUNCT
hjic-87	356	16	41	41	NUM
hjic-87	356	17	.	.	PUNCT
hjic-87	356	18	schmitt	schmitt	PROPN
hjic-87	356	19	w.	w.	PROPN
hjic-87	356	20	j.	j.	PROPN
hjic-87	356	21	:	:	PUNCT
hjic-87	356	22	u.s	u.s	PROPN
hjic-87	356	23	.	.	PROPN
hjic-87	356	24	pat	pat	PROPN
hjic-87	356	25	.	.	PROPN
hjic-87	357	1	5,707,634	5,707,634	NUM
hjic-87	357	2	(	(	PUNCT
hjic-87	357	3	1998	1998	NUM
hjic-87	357	4	)	)	PUNCT
hjic-87	357	5	42	42	NUM
hjic-87	357	6	.	.	PUNCT
hjic-87	358	1	manning	man	VERB
hjic-87	358	2	m.	m.	NOUN
hjic-87	358	3	c.	c.	PROPN
hjic-87	358	4	,	,	PUNCT
hjic-87	358	5	randolph	randolph	PROPN
hjic-87	358	6	t.	t.	PROPN
hjic-87	358	7	w.	w.	PROPN
hjic-87	358	8	,	,	PUNCT
hjic-87	358	9	shefter	shefter	PROPN
hjic-87	358	10	e.	e.	PROPN
hjic-87	358	11	and	and	CCONJ
hjic-87	358	12	falk	falk	PROPN
hjic-87	358	13	r.	r.	PROPN
hjic-87	358	14	f.	f.	PROPN
hjic-87	358	15	:	:	PUNCT
hjic-87	358	16	u.s	u.s	PROPN
hjic-87	358	17	.	.	PROPN
hjic-87	358	18	pat	pat	PROPN
hjic-87	358	19	.	.	PROPN
hjic-87	359	1	5,770,559	5,770,559	NUM
hjic-87	359	2	(	(	PUNCT
hjic-87	359	3	1998	1998	NUM
hjic-87	359	4	)	)	PUNCT
hjic-87	359	5	43	43	NUM
hjic-87	359	6	.	.	PUNCT
hjic-87	360	1	falk	falk	PROPN
hjic-87	360	2	r.	r.	PROPN
hjic-87	360	3	f.	f.	PROPN
hjic-87	360	4	,	,	PUNCT
hjic-87	360	5	randolph	randolph	PROPN
hjic-87	360	6	t.	t.	PROPN
hjic-87	360	7	w.	w.	PROPN
hjic-87	360	8	,	,	PUNCT
hjic-87	360	9	meyer	meyer	PROPN
hjic-87	360	10	j.	j.	PROPN
hjic-87	360	11	d.	d.	PROPN
hjic-87	360	12	,	,	PUNCT
hjic-87	360	13	kelly	kelly	PROPN
hjic-87	360	14	r.	r.	PROPN
hjic-87	360	15	m.	m.	PROPN
hjic-87	360	16	and	and	CCONJ
hjic-87	360	17	manning	man	VERB
hjic-87	360	18	m.	m.	NOUN
hjic-87	360	19	c.	c.	PROPN
hjic-87	360	20	:	:	PUNCT
hjic-87	360	21	j.	j.	PROPN
hjic-87	360	22	cont	cont	PROPN
hjic-87	360	23	.	.	PUNCT
hjic-87	361	1	rel	rel	PROPN
hjic-87	361	2	.	.	PROPN
hjic-87	361	3	,	,	PUNCT
hjic-87	361	4	1997	1997	NUM
hjic-87	361	5	,	,	PUNCT
hjic-87	361	6	44	44	NUM
hjic-87	361	7	,	,	PUNCT
hjic-87	361	8	77	77	NUM
hjic-87	361	9	-	-	SYM
hjic-87	361	10	85	85	NUM
hjic-87	361	11	44	44	NUM
hjic-87	361	12	.	.	PUNCT
hjic-87	362	1	falk	falk	PROPN
hjic-87	362	2	r.	r.	PROPN
hjic-87	362	3	f.	f.	PROPN
hjic-87	362	4	,	,	PUNCT
hjic-87	362	5	randolph	randolph	PROPN
hjic-87	362	6	t.	t.	PROPN
hjic-87	362	7	w.	w.	PROPN
hjic-87	362	8	:	:	PUNCT
hjic-87	362	9	pharm	pharm	PROPN
hjic-87	362	10	.	.	PUNCT
hjic-87	363	1	res	re	NOUN
hjic-87	363	2	.	.	PROPN
hjic-87	363	3	,	,	PUNCT
hjic-87	363	4	1998	1998	NUM
hjic-87	363	5	,	,	PUNCT
hjic-87	363	6	15	15	NUM
hjic-87	363	7	,	,	PUNCT
hjic-87	363	8	8	8	NUM
hjic-87	363	9	,	,	PUNCT
hjic-87	363	10	1233	1233	NUM
hjic-87	363	11	-	-	SYM
hjic-87	363	12	1237	1237	NUM
hjic-87	363	13	45	45	NUM
hjic-87	363	14	.	.	PUNCT
hjic-87	364	1	taki	taki	PROPN
hjic-87	364	2	s.	s.	PROPN
hjic-87	364	3	,	,	PUNCT
hjic-87	364	4	badens	baden	VERB
hjic-87	364	5	e.	e.	PROPN
hjic-87	364	6	and	and	CCONJ
hjic-87	364	7	charbit	charbit	PROPN
hjic-87	364	8	g.	g.	PROPN
hjic-87	364	9	:	:	PUNCT
hjic-87	364	10	j.	j.	PROPN
hjic-87	364	11	supercrit	supercrit	PROPN
hjic-87	364	12	.	.	PUNCT
hjic-87	365	1	fluids	fluid	NOUN
hjic-87	365	2	,	,	PUNCT
hjic-87	365	3	2001	2001	NUM
hjic-87	365	4	,	,	PUNCT
hjic-87	365	5	21	21	NUM
hjic-87	365	6	,	,	PUNCT
hjic-87	365	7	61	61	NUM
hjic-87	365	8	-	-	SYM
hjic-87	365	9	70	70	NUM
hjic-87	365	10	46	46	NUM
hjic-87	365	11	.	.	PUNCT
hjic-87	366	1	sze	sze	PROPN
hjic-87	366	2	tu	tu	PROPN
hjic-87	366	3	l.	l.	PROPN
hjic-87	366	4	,	,	PUNCT
hjic-87	366	5	dehghani	dehghani	PROPN
hjic-87	366	6	f.	f.	PROPN
hjic-87	366	7	,	,	PUNCT
hjic-87	366	8	dillow	dillow	PROPN
hjic-87	366	9	a.	a.	PROPN
hjic-87	366	10	k.	k.	PROPN
hjic-87	366	11	and	and	CCONJ
hjic-87	366	12	foster	foster	PROPN
hjic-87	366	13	n.	n.	PROPN
hjic-87	366	14	r.	r.	PROPN
hjic-87	366	15	:	:	PUNCT
hjic-87	366	16	application	application	NOUN
hjic-87	366	17	of	of	ADP
hjic-87	366	18	dense	dense	ADJ
hjic-87	366	19	gases	gas	NOUN
hjic-87	366	20	in	in	ADP
hjic-87	366	21	pharmaceutical	pharmaceutical	NOUN
hjic-87	366	22	processing	processing	NOUN
hjic-87	366	23	;	;	PUNCT
hjic-87	366	24	5th	5th	ADJ
hjic-87	366	25	meeting	meeting	NOUN
hjic-87	366	26	on	on	ADP
hjic-87	366	27	supercritical	supercritical	ADJ
hjic-87	366	28	fluids	fluid	NOUN
hjic-87	366	29	,	,	PUNCT
hjic-87	366	30	inpl	inpl	NOUN
hjic-87	366	31	,	,	PUNCT
hjic-87	366	32	vandeuvre	vandeuvre	NOUN
hjic-87	366	33	,	,	PUNCT
hjic-87	366	34	(	(	PUNCT
hjic-87	366	35	france	france	PROPN
hjic-87	366	36	)	)	PUNCT
hjic-87	366	37	1998	1998	NUM
hjic-87	366	38	,	,	PUNCT
hjic-87	366	39	1	1	NUM
hjic-87	366	40	,	,	PUNCT
hjic-87	366	41	263	263	NUM
hjic-87	366	42	55	55	NUM
hjic-87	366	43	47	47	NUM
hjic-87	366	44	.	.	PUNCT
hjic-87	367	1	sze	sze	PROPN
hjic-87	367	2	tu	tu	PROPN
hjic-87	367	3	l.	l.	PROPN
hjic-87	367	4	,	,	PUNCT
hjic-87	367	5	dehghani	dehghani	PROPN
hjic-87	367	6	f.	f.	PROPN
hjic-87	367	7	and	and	CCONJ
hjic-87	367	8	foster	foster	PROPN
hjic-87	367	9	n.	n.	PROPN
hjic-87	367	10	r.	r.	PROPN
hjic-87	367	11	:	:	PUNCT
hjic-87	367	12	powder	powder	NOUN
hjic-87	367	13	tech	tech	NOUN
hjic-87	367	14	.	.	PUNCT
hjic-87	367	15	,	,	PUNCT
hjic-87	367	16	2002	2002	NUM
hjic-87	367	17	,	,	PUNCT
hjic-87	367	18	126	126	NUM
hjic-87	367	19	,	,	PUNCT
hjic-87	367	20	134	134	NUM
hjic-87	367	21	-	-	SYM
hjic-87	367	22	149	149	NUM
hjic-87	367	23	48	48	NUM
hjic-87	367	24	.	.	PUNCT
hjic-87	368	1	bleich	bleich	PROPN
hjic-87	368	2	j.	j.	PROPN
hjic-87	368	3	,	,	PUNCT
hjic-87	368	4	kleinebudde	kleinebudde	PROPN
hjic-87	368	5	p.	p.	PROPN
hjic-87	368	6	and	and	CCONJ
hjic-87	368	7	müller	müller	PROPN
hjic-87	368	8	b.	b.	PROPN
hjic-87	368	9	w.	w.	PROPN
hjic-87	368	10	:	:	PUNCT
hjic-87	368	11	int	int	PROPN
hjic-87	368	12	.	.	PUNCT
hjic-87	369	1	j.	j.	PROPN
hjic-87	369	2	pharm	pharm	PROPN
hjic-87	369	3	.	.	PROPN
hjic-87	369	4	,	,	PUNCT
hjic-87	369	5	1994	1994	NUM
hjic-87	369	6	,	,	PUNCT
hjic-87	369	7	106	106	NUM
hjic-87	369	8	,	,	PUNCT
hjic-87	369	9	77	77	NUM
hjic-87	369	10	49	49	NUM
hjic-87	369	11	.	.	PUNCT
hjic-87	370	1	bleich	bleich	PROPN
hjic-87	370	2	j.	j.	PROPN
hjic-87	370	3	and	and	CCONJ
hjic-87	370	4	müller	müller	PROPN
hjic-87	370	5	b.	b.	PROPN
hjic-87	370	6	w.	w.	PROPN
hjic-87	370	7	:	:	PUNCT
hjic-87	370	8	j.	j.	PROPN
hjic-87	370	9	of	of	ADP
hjic-87	370	10	microencapsulation	microencapsulation	NOUN
hjic-87	370	11	,	,	PUNCT
hjic-87	370	12	1996	1996	NUM
hjic-87	370	13	,	,	PUNCT
hjic-87	370	14	13	13	NUM
hjic-87	370	15	(	(	PUNCT
hjic-87	370	16	2	2	NUM
hjic-87	370	17	)	)	PUNCT
hjic-87	370	18	131	131	NUM
hjic-87	370	19	-	-	SYM
hjic-87	370	20	139	139	NUM
hjic-87	370	21	50	50	NUM
hjic-87	370	22	.	.	PUNCT
hjic-87	371	1	ruchatz	ruchatz	PROPN
hjic-87	371	2	f.	f.	PROPN
hjic-87	371	3	and	and	CCONJ
hjic-87	371	4	müller	müller	PROPN
hjic-87	371	5	b.	b.	PROPN
hjic-87	371	6	w.	w.	PROPN
hjic-87	371	7	:	:	PUNCT
hjic-87	371	8	eur	eur	PROPN
hjic-87	371	9	.	.	PUNCT
hjic-87	372	1	j.	j.	PROPN
hjic-87	372	2	pharm	pharm	PROPN
hjic-87	372	3	.	.	PUNCT
hjic-87	373	1	sci	sci	PROPN
hjic-87	373	2	.	.	PROPN
hjic-87	373	3	,	,	PUNCT
hjic-87	373	4	1996	1996	NUM
hjic-87	373	5	,	,	PUNCT
hjic-87	373	6	4(1	4(1	NOUN
hjic-87	373	7	)	)	PUNCT
hjic-87	373	8	,	,	PUNCT
hjic-87	373	9	s134	s134	PROPN
hjic-87	373	10	51	51	NUM
hjic-87	373	11	.	.	PUNCT
hjic-87	374	1	chou	chou	PROPN
hjic-87	374	2	y.	y.	PROPN
hjic-87	374	3	h.	h.	PROPN
hjic-87	374	4	and	and	CCONJ
hjic-87	374	5	tomasko	tomasko	PROPN
hjic-87	374	6	d.	d.	PROPN
hjic-87	374	7	l.	l.	PROPN
hjic-87	374	8	:	:	PUNCT
hjic-87	374	9	gas	gas	NOUN
hjic-87	374	10	recrystallization	recrystallization	NOUN
hjic-87	374	11	of	of	ADP
hjic-87	374	12	polymer	polymer	NOUN
hjic-87	374	13	-	-	PUNCT
hjic-87	374	14	pharmaceutical	pharmaceutical	NOUN
hjic-87	374	15	composite	composite	ADJ
hjic-87	374	16	particles	particle	NOUN
hjic-87	374	17	.	.	PUNCT
hjic-87	375	1	4th	4th	ADJ
hjic-87	375	2	international	international	ADJ
hjic-87	375	3	symposium	symposium	NOUN
hjic-87	375	4	on	on	ADP
hjic-87	375	5	supercritical	supercritical	ADJ
hjic-87	375	6	fluids	fluid	NOUN
hjic-87	375	7	,	,	PUNCT
hjic-87	375	8	sendai	sendai	PROPN
hjic-87	375	9	(	(	PUNCT
hjic-87	375	10	japan	japan	PROPN
hjic-87	375	11	)	)	PUNCT
hjic-87	375	12	,	,	PUNCT
hjic-87	375	13	1114	1114	NUM
hjic-87	375	14	may	may	PROPN
hjic-87	375	15	1997	1997	NUM
hjic-87	375	16	,	,	PUNCT
hjic-87	375	17	55	55	NUM
hjic-87	375	18	-	-	SYM
hjic-87	375	19	57	57	NUM
hjic-87	375	20	52	52	NUM
hjic-87	375	21	.	.	PUNCT
hjic-87	376	1	steckel	steckel	PROPN
hjic-87	376	2	h.	h.	PROPN
hjic-87	376	3	,	,	PUNCT
hjic-87	376	4	thies	thies	PROPN
hjic-87	376	5	j.	j.	PROPN
hjic-87	376	6	and	and	CCONJ
hjic-87	376	7	müller	müller	PROPN
hjic-87	376	8	b.	b.	PROPN
hjic-87	376	9	w.	w.	PROPN
hjic-87	376	10	:	:	PUNCT
hjic-87	376	11	int	int	PROPN
hjic-87	376	12	.	.	PUNCT
hjic-87	377	1	j.	j.	PROPN
hjic-87	377	2	pharma	pharma	PROPN
hjic-87	377	3	.	.	PROPN
hjic-87	377	4	,	,	PUNCT
hjic-87	377	5	1997	1997	NUM
hjic-87	377	6	,	,	PUNCT
hjic-87	377	7	152	152	NUM
hjic-87	377	8	,	,	PUNCT
hjic-87	377	9	99	99	NUM
hjic-87	377	10	-	-	SYM
hjic-87	377	11	110	110	NUM
hjic-87	377	12	53	53	NUM
hjic-87	377	13	.	.	PUNCT
hjic-87	378	1	witschi	witschi	PROPN
hjic-87	378	2	c.	c.	PROPN
hjic-87	378	3	and	and	CCONJ
hjic-87	378	4	doelker	doelker	PROPN
hjic-87	378	5	e.	e.	PROPN
hjic-87	378	6	:	:	PUNCT
hjic-87	378	7	j.	j.	PROPN
hjic-87	378	8	controlled	control	VERB
hjic-87	378	9	release	release	NOUN
hjic-87	378	10	,	,	PUNCT
hjic-87	378	11	1998a	1998a	NUM
hjic-87	378	12	,	,	PUNCT
hjic-87	378	13	51	51	NUM
hjic-87	378	14	,	,	PUNCT
hjic-87	378	15	327	327	NUM
hjic-87	378	16	-	-	SYM
hjic-87	378	17	341	341	NUM
hjic-87	378	18	54	54	NUM
hjic-87	378	19	.	.	PUNCT
hjic-87	379	1	witschi	witschi	PROPN
hjic-87	379	2	c.	c.	PROPN
hjic-87	379	3	and	and	CCONJ
hjic-87	379	4	doelker	doelker	PROPN
hjic-87	379	5	e.	e.	PROPN
hjic-87	379	6	:	:	PUNCT
hjic-87	379	7	int	int	PROPN
hjic-87	379	8	.	.	PUNCT
hjic-87	380	1	j.	j.	PROPN
hjic-87	380	2	pharm	pharm	PROPN
hjic-87	380	3	.	.	PUNCT
hjic-87	380	4	,	,	PUNCT
hjic-87	380	5	1998b	1998b	NUM
hjic-87	380	6	,	,	PUNCT
hjic-87	380	7	171	171	NUM
hjic-87	380	8	,	,	PUNCT
hjic-87	380	9	1	1	NUM
hjic-87	380	10	-	-	SYM
hjic-87	380	11	18	18	NUM
hjic-87	380	12	55	55	NUM
hjic-87	380	13	.	.	PUNCT
hjic-87	381	1	engwicht	engwicht	PROPN
hjic-87	381	2	a.	a.	PROPN
hjic-87	381	3	,	,	PUNCT
hjic-87	381	4	girreser	girreser	PROPN
hjic-87	381	5	u.	u.	PROPN
hjic-87	381	6	and	and	CCONJ
hjic-87	381	7	müller	müller	PROPN
hjic-87	381	8	b.	b.	PROPN
hjic-87	381	9	w	w	PROPN
hjic-87	381	10	,	,	PUNCT
hjic-87	381	11	int	int	PROPN
hjic-87	381	12	.	.	PUNCT
hjic-87	382	1	j.	j.	PROPN
hjic-87	382	2	pharm	pharm	PROPN
hjic-87	382	3	.	.	PUNCT
hjic-87	383	1	1999	1999	NUM
hjic-87	383	2	,	,	PUNCT
hjic-87	383	3	185	185	NUM
hjic-87	383	4	,	,	PUNCT
hjic-87	383	5	61	61	NUM
hjic-87	383	6	72	72	NUM
hjic-87	383	7	56	56	NUM
hjic-87	383	8	.	.	PUNCT
hjic-87	384	1	elvassore	elvassore	PROPN
hjic-87	384	2	n.	n.	NOUN
hjic-87	384	3	,	,	PUNCT
hjic-87	384	4	bertucco	bertucco	NOUN
hjic-87	384	5	a.	a.	NOUN
hjic-87	384	6	and	and	CCONJ
hjic-87	384	7	caliceti	caliceti	PROPN
hjic-87	384	8	p.	p.	NOUN
hjic-87	384	9	:	:	PUNCT
hjic-87	385	1	production	production	NOUN
hjic-87	385	2	of	of	ADP
hjic-87	385	3	protein	protein	NOUN
hjic-87	385	4	-	-	PUNCT
hjic-87	385	5	polymer	polymer	NOUN
hjic-87	385	6	microcapsules	microcapsule	NOUN
hjic-87	385	7	by	by	ADP
hjic-87	385	8	supercritical	supercritical	ADJ
hjic-87	385	9	anti	anti	ADJ
hjic-87	385	10	-	-	ADJ
hjic-87	385	11	solvent	solvent	ADJ
hjic-87	385	12	techniques	technique	NOUN
hjic-87	385	13	,	,	PUNCT
hjic-87	385	14	5th	5th	ADJ
hjic-87	385	15	international	international	ADJ
hjic-87	385	16	symposium	symposium	NOUN
hjic-87	385	17	on	on	ADP
hjic-87	385	18	supercritical	supercritical	ADJ
hjic-87	385	19	fluids	fluid	NOUN
hjic-87	385	20	,	,	PUNCT
hjic-87	385	21	atlanta	atlanta	PROPN
hjic-87	385	22	(	(	PUNCT
hjic-87	385	23	usa	usa	PROPN
hjic-87	385	24	)	)	PUNCT
hjic-87	385	25	,	,	PUNCT
hjic-87	385	26	812	812	NUM
hjic-87	385	27	april	april	PROPN
hjic-87	385	28	,	,	PUNCT
hjic-87	385	29	2000	2000	NUM
hjic-87	385	30	57	57	NUM
hjic-87	385	31	.	.	PUNCT
hjic-87	386	1	elvassore	elvassore	PROPN
hjic-87	386	2	n.	n.	NOUN
hjic-87	386	3	,	,	PUNCT
hjic-87	386	4	bertucco	bertucco	NOUN
hjic-87	386	5	a.	a.	NOUN
hjic-87	386	6	and	and	CCONJ
hjic-87	386	7	caliceti	caliceti	PROPN
hjic-87	386	8	p.	p.	NOUN
hjic-87	386	9	:	:	PUNCT
hjic-87	387	1	j.	j.	PROPN
hjic-87	387	2	pharm	pharm	PROPN
hjic-87	387	3	.	.	PUNCT
hjic-87	388	1	sci	sci	PROPN
hjic-87	388	2	.	.	PROPN
hjic-87	388	3	2001a	2001a	NUM
hjic-87	388	4	,	,	PUNCT
hjic-87	388	5	90	90	NUM
hjic-87	388	6	,	,	PUNCT
hjic-87	388	7	1628	1628	NUM
hjic-87	388	8	1636	1636	NUM
hjic-87	388	9	58	58	NUM
hjic-87	388	10	.	.	PUNCT
hjic-87	389	1	elvassore	elvassore	PROPN
hjic-87	389	2	n.	n.	PROPN
hjic-87	389	3	,	,	PUNCT
hjic-87	389	4	bertucco	bertucco	NOUN
hjic-87	389	5	a.	a.	NOUN
hjic-87	389	6	and	and	CCONJ
hjic-87	389	7	caliceti	caliceti	PROPN
hjic-87	389	8	p.	p.	NOUN
hjic-87	389	9	:	:	PUNCT
hjic-87	390	1	ind	ind	PROPN
hjic-87	390	2	.	.	PUNCT
hjic-87	391	1	eng	eng	PROPN
hjic-87	391	2	.	.	PROPN
hjic-87	391	3	chem	chem	PROPN
hjic-87	391	4	.	.	PUNCT
hjic-87	392	1	res	re	NOUN
hjic-87	392	2	.	.	PROPN
hjic-87	392	3	,	,	PUNCT
hjic-87	392	4	2001b	2001b	NUM
hjic-87	392	5	,	,	PUNCT
hjic-87	392	6	40	40	NUM
hjic-87	392	7	,	,	PUNCT
hjic-87	392	8	795	795	NUM
hjic-87	392	9	-	-	SYM
hjic-87	392	10	800	800	NUM
hjic-87	392	11	59	59	NUM
hjic-87	392	12	.	.	PUNCT
hjic-87	393	1	martin	martin	PROPN
hjic-87	393	2	t.	t.	PROPN
hjic-87	393	3	m.	m.	PROPN
hjic-87	393	4	,	,	PUNCT
hjic-87	393	5	bandi	bandi	PROPN
hjic-87	393	6	n.	n.	PROPN
hjic-87	393	7	,	,	PUNCT
hjic-87	393	8	shultz	shultz	NOUN
hjic-87	393	9	r	r	PROPN
hjic-87	393	10	,	,	PUNCT
hjic-87	393	11	roberts	roberts	PROPN
hjic-87	393	12	c.	c.	PROPN
hjic-87	393	13	b.	b.	PROPN
hjic-87	393	14	and	and	CCONJ
hjic-87	393	15	kompella	kompella	PROPN
hjic-87	393	16	u.	u.	PROPN
hjic-87	393	17	b.	b.	PROPN
hjic-87	393	18	:	:	PUNCT
hjic-87	393	19	aaps	aaps	PROPN
hjic-87	393	20	pharm	pharm	PROPN
hjic-87	393	21	.	.	PUNCT
hjic-87	394	1	sci	sci	PROPN
hjic-87	394	2	.	.	PUNCT
hjic-87	394	3	tech	tech	PROPN
hjic-87	394	4	.	.	PROPN
hjic-87	394	5	,	,	PUNCT
hjic-87	394	6	2002	2002	NUM
hjic-87	394	7	,	,	PUNCT
hjic-87	394	8	3(3	3(3	NUM
hjic-87	394	9	)	)	PUNCT
hjic-87	394	10	,	,	PUNCT
hjic-87	394	11	e18	e18	VERB
hjic-87	394	12	60	60	NUM
hjic-87	394	13	.	.	PUNCT
hjic-87	395	1	bustami	bustami	PROPN
hjic-87	395	2	r.	r.	PROPN
hjic-87	395	3	t.	t.	PROPN
hjic-87	395	4	,	,	PUNCT
hjic-87	395	5	chan	chan	PROPN
hjic-87	395	6	h.	h.	PROPN
hjic-87	395	7	k.	k.	PROPN
hjic-87	395	8	,	,	PUNCT
hjic-87	395	9	sweeney	sweeney	PROPN
hjic-87	395	10	t.	t.	PROPN
hjic-87	395	11	,	,	PUNCT
hjic-87	395	12	dehghani	dehghani	PROPN
hjic-87	395	13	f.	f.	PROPN
hjic-87	395	14	and	and	CCONJ
hjic-87	395	15	foster	foster	PROPN
hjic-87	395	16	n.	n.	PROPN
hjic-87	395	17	r.	r.	PROPN
hjic-87	395	18	:	:	PUNCT
hjic-87	395	19	pharm	pharm	PROPN
hjic-87	395	20	.	.	PUNCT
hjic-87	396	1	res	re	NOUN
hjic-87	396	2	.	.	PROPN
hjic-87	396	3	,	,	PUNCT
hjic-87	396	4	2003	2003	NUM
hjic-87	396	5	,	,	PUNCT
hjic-87	396	6	20	20	NUM
hjic-87	396	7	,	,	PUNCT
hjic-87	396	8	(	(	PUNCT
hjic-87	396	9	12	12	NUM
hjic-87	396	10	)	)	PUNCT
hjic-87	396	11	,	,	PUNCT
hjic-87	396	12	2028	2028	NUM
hjic-87	396	13	-	-	SYM
hjic-87	396	14	2035	2035	NUM
hjic-87	396	15	61	61	NUM
hjic-87	396	16	.	.	PUNCT
hjic-87	397	1	meure	meure	PROPN
hjic-87	397	2	la	la	PROPN
hjic-87	397	3	,	,	PUNCT
hjic-87	397	4	warwick	warwick	PROPN
hjic-87	397	5	b	b	PROPN
hjic-87	397	6	,	,	PUNCT
hjic-87	397	7	and	and	CCONJ
hjic-87	397	8	dehghani	dehghani	PROPN
hjic-87	397	9	f.	f.	PROPN
hjic-87	397	10	:	:	PUNCT
hjic-87	398	1	ind	ind	PROPN
hjic-87	398	2	.	.	PUNCT
hjic-87	399	1	eng	eng	PROPN
hjic-87	399	2	.	.	PROPN
hjic-87	399	3	chem	chem	PROPN
hjic-87	399	4	.	.	PUNCT
hjic-87	400	1	res	re	NOUN
hjic-87	400	2	.	.	PUNCT
hjic-87	401	1	2004	2004	NUM
hjic-87	401	2	,	,	PUNCT
hjic-87	401	3	43(4	43(4	NOUN
hjic-87	401	4	)	)	PUNCT
hjic-87	401	5	,	,	PUNCT
hjic-87	401	6	1103	1103	NUM
hjic-87	401	7	-	-	SYM
hjic-87	401	8	1112	1112	NUM
hjic-87	401	9	62	62	NUM
hjic-87	401	10	.	.	PUNCT
hjic-87	402	1	caliceti	caliceti	PROPN
hjic-87	402	2	p.	p.	PROPN
hjic-87	402	3	,	,	PUNCT
hjic-87	402	4	salmaso	salmaso	PROPN
hjic-87	402	5	s.	s.	PROPN
hjic-87	402	6	,	,	PUNCT
hjic-87	402	7	elvassore	elvassore	NOUN
hjic-87	402	8	n.	n.	NOUN
hjic-87	402	9	and	and	CCONJ
hjic-87	402	10	bertucco	bertucco	PROPN
hjic-87	402	11	a.	a.	PROPN
hjic-87	402	12	:	:	PUNCT
hjic-87	402	13	j.	j.	PROPN
hjic-87	402	14	controlled	control	VERB
hjic-87	402	15	release	release	NOUN
hjic-87	402	16	,	,	PUNCT
hjic-87	402	17	2004	2004	NUM
hjic-87	402	18	,	,	PUNCT
hjic-87	402	19	94	94	NUM
hjic-87	402	20	,	,	PUNCT
hjic-87	402	21	195	195	NUM
hjic-87	402	22	-	-	SYM
hjic-87	402	23	205	205	NUM
hjic-87	402	24	63	63	NUM
hjic-87	402	25	.	.	PUNCT
hjic-87	403	1	york	york	PROPN
hjic-87	403	2	p.	p.	PROPN
hjic-87	403	3	and	and	CCONJ
hjic-87	403	4	hanna	hanna	PROPN
hjic-87	403	5	m.	m.	NOUN
hjic-87	403	6	:	:	PUNCT
hjic-87	403	7	wo	will	AUX
hjic-87	403	8	pat	pat	PROPN
hjic-87	403	9	.	.	PROPN
hjic-87	404	1	95/01221	95/01221	NUM
hjic-87	404	2	(	(	PUNCT
hjic-87	404	3	1995	1995	NUM
hjic-87	404	4	)	)	PUNCT
hjic-87	404	5	.	.	PUNCT
hjic-87	405	1	64	64	NUM
hjic-87	405	2	.	.	PUNCT
hjic-87	406	1	york	york	PROPN
hjic-87	406	2	p.	p.	PROPN
hjic-87	406	3	and	and	CCONJ
hjic-87	406	4	hanna	hanna	PROPN
hjic-87	406	5	m.	m.	NOUN
hjic-87	406	6	:	:	PUNCT
hjic-87	406	7	wo	will	AUX
hjic-87	406	8	pat	pat	PROPN
hjic-87	406	9	.	.	PROPN
hjic-87	407	1	96/00610	96/00610	NUM
hjic-87	407	2	(	(	PUNCT
hjic-87	407	3	1996	1996	NUM
hjic-87	407	4	)	)	PUNCT
hjic-87	407	5	65	65	NUM
hjic-87	407	6	.	.	PUNCT
hjic-87	408	1	york	york	PROPN
hjic-87	408	2	p.	p.	PROPN
hjic-87	408	3	and	and	CCONJ
hjic-87	408	4	hanna	hanna	PROPN
hjic-87	408	5	m.	m.	NOUN
hjic-87	408	6	:	:	PUNCT
hjic-87	408	7	wo	will	AUX
hjic-87	408	8	pat	pat	PROPN
hjic-87	408	9	.	.	PROPN
hjic-87	409	1	98/36825	98/36825	PROPN
hjic-87	409	2	(	(	PUNCT
hjic-87	409	3	1998	1998	NUM
hjic-87	409	4	)	)	PUNCT
hjic-87	409	5	66	66	NUM
hjic-87	409	6	.	.	PUNCT
hjic-87	410	1	york	york	PROPN
hjic-87	410	2	p.	p.	PROPN
hjic-87	410	3	and	and	CCONJ
hjic-87	410	4	hanna	hanna	PROPN
hjic-87	410	5	m.	m.	NOUN
hjic-87	410	6	:	:	PUNCT
hjic-87	410	7	wo	will	AUX
hjic-87	410	8	pat	pat	PROPN
hjic-87	410	9	.	.	PUNCT
hjic-87	411	1	99/59710	99/59710	PROPN
hjic-87	411	2	(	(	PUNCT
hjic-87	411	3	1999	1999	NUM
hjic-87	411	4	)	)	PUNCT
hjic-87	411	5	67	67	NUM
hjic-87	411	6	.	.	PUNCT
hjic-87	412	1	york	york	PROPN
hjic-87	412	2	p.	p.	PROPN
hjic-87	412	3	,	,	PUNCT
hjic-87	412	4	walker	walker	PROPN
hjic-87	412	5	s.	s.	PROPN
hjic-87	412	6	e.	e.	PROPN
hjic-87	412	7	,	,	PUNCT
hjic-87	412	8	wilkins	wilkins	PROPN
hjic-87	412	9	s.	s.	PROPN
hjic-87	412	10	a.	a.	PROPN
hjic-87	412	11	,	,	PUNCT
hjic-87	412	12	storey	storey	PROPN
hjic-87	412	13	r.	r.	PROPN
hjic-87	412	14	a.	a.	PROPN
hjic-87	412	15	and	and	CCONJ
hjic-87	412	16	harland	harland	PROPN
hjic-87	412	17	r.	r.	PROPN
hjic-87	412	18	s.	s.	PROPN
hjic-87	412	19	:	:	PUNCT
hjic-87	412	20	wo	will	AUX
hjic-87	412	21	pat	pat	PROPN
hjic-87	412	22	.	.	PROPN
hjic-87	412	23	01/15664	01/15664	X
hjic-87	412	24	(	(	PUNCT
hjic-87	412	25	2001	2001	NUM
hjic-87	412	26	)	)	PUNCT
hjic-87	412	27	68	68	NUM
hjic-87	412	28	.	.	PUNCT
hjic-87	413	1	hanna	hanna	PROPN
hjic-87	413	2	m.	m.	PROPN
hjic-87	413	3	,	,	PUNCT
hjic-87	413	4	shekunov	shekunov	PROPN
hjic-87	413	5	b.	b.	PROPN
hjic-87	413	6	:	:	PUNCT
hjic-87	413	7	wo	will	AUX
hjic-87	413	8	pat	pat	PROPN
hjic-87	413	9	.	.	PROPN
hjic-87	414	1	99/44733	99/44733	NUM
hjic-87	414	2	(	(	PUNCT
hjic-87	414	3	1999	1999	NUM
hjic-87	414	4	)	)	PUNCT
hjic-87	414	5	69	69	NUM
hjic-87	414	6	.	.	PUNCT
hjic-87	415	1	juppo	juppo	PROPN
hjic-87	415	2	a.	a.	PROPN
hjic-87	415	3	m.	m.	PROPN
hjic-87	415	4	,	,	PUNCT
hjic-87	415	5	boissier	boissier	PROPN
hjic-87	415	6	c.	c.	PROPN
hjic-87	415	7	,	,	PUNCT
hjic-87	415	8	khoo	khoo	PROPN
hjic-87	415	9	c.	c.	PROPN
hjic-87	415	10	:	:	PUNCT
hjic-87	415	11	int	int	PROPN
hjic-87	415	12	.	.	PUNCT
hjic-87	416	1	j.	j.	PROPN
hjic-87	416	2	pharm	pharm	PROPN
hjic-87	416	3	.	.	PROPN
hjic-87	416	4	,	,	PUNCT
hjic-87	416	5	2003	2003	NUM
hjic-87	416	6	,	,	PUNCT
hjic-87	416	7	250	250	NUM
hjic-87	416	8	,	,	PUNCT
hjic-87	416	9	385	385	NUM
hjic-87	416	10	-	-	SYM
hjic-87	416	11	401	401	NUM
hjic-87	416	12	70	70	NUM
hjic-87	416	13	.	.	PUNCT
hjic-87	417	1	ghaderi	ghaderi	PROPN
hjic-87	417	2	r.	r.	PROPN
hjic-87	417	3	,	,	PUNCT
hjic-87	417	4	artursson	artursson	PROPN
hjic-87	417	5	p.	p.	PROPN
hjic-87	417	6	and	and	CCONJ
hjic-87	417	7	carlfors	carlfor	NOUN
hjic-87	418	1	j.	j.	PROPN
hjic-87	418	2	:	:	PUNCT
hjic-87	418	3	eur	eur	PROPN
hjic-87	418	4	.	.	PUNCT
hjic-87	419	1	j.	j.	PROPN
hjic-87	419	2	pharm	pharm	PROPN
hjic-87	419	3	.	.	PUNCT
hjic-87	420	1	sci	sci	PROPN
hjic-87	420	2	.	.	PROPN
hjic-87	420	3	,	,	PUNCT
hjic-87	420	4	2000	2000	NUM
hjic-87	420	5	,	,	PUNCT
hjic-87	420	6	10	10	NUM
hjic-87	420	7	,	,	PUNCT
hjic-87	420	8	1	1	NUM
hjic-87	420	9	-	-	SYM
hjic-87	420	10	9	9	NUM
hjic-87	420	11	71	71	NUM
hjic-87	420	12	.	.	PUNCT
hjic-87	420	13	tservistas	tservistas	PROPN
hjic-87	420	14	m.	m.	NOUN
hjic-87	420	15	,	,	PUNCT
hjic-87	420	16	levy	levy	NOUN
hjic-87	420	17	m.	m.	NOUN
hjic-87	420	18	s.	s.	PROPN
hjic-87	420	19	,	,	PUNCT
hjic-87	420	20	lo	lo	PROPN
hjic-87	420	21	-	-	PUNCT
hjic-87	420	22	yim	yim	PROPN
hjic-87	420	23	m.y	m.y	PROPN
hjic-87	420	24	.	.	PROPN
hjic-87	420	25	a.	a.	PROPN
hjic-87	420	26	,	,	PUNCT
hjic-87	420	27	o'kennedy	o'kennedy	PROPN
hjic-87	420	28	r.	r.	PROPN
hjic-87	420	29	d.	d.	PROPN
hjic-87	420	30	,	,	PUNCT
hjic-87	420	31	york	york	PROPN
hjic-87	420	32	p.	p.	PROPN
hjic-87	420	33	,	,	PUNCT
hjic-87	420	34	humphrey	humphrey	PROPN
hjic-87	420	35	g.	g.	PROPN
hjic-87	421	1	o.	o.	PROPN
hjic-87	421	2	and	and	CCONJ
hjic-87	421	3	hoare	hoare	PROPN
hjic-87	421	4	m.	m.	PROPN
hjic-87	421	5	:	:	PUNCT
hjic-87	421	6	biotech	biotech	NOUN
hjic-87	421	7	.	.	PUNCT
hjic-87	422	1	bioeng	bioeng	PROPN
hjic-87	422	2	.	.	PROPN
hjic-87	423	1	2001	2001	NUM
hjic-87	423	2	,	,	PUNCT
hjic-87	423	3	72	72	NUM
hjic-87	423	4	,	,	PUNCT
hjic-87	423	5	1218	1218	NUM
hjic-87	423	6	72	72	NUM
hjic-87	423	7	.	.	PUNCT
hjic-87	424	1	squillante	squillante	PROPN
hjic-87	424	2	iii	iii	PROPN
hjic-87	424	3	e.	e.	PROPN
hjic-87	424	4	,	,	PUNCT
hjic-87	424	5	and	and	CCONJ
hjic-87	424	6	mehta	mehta	PROPN
hjic-87	424	7	k.	k.	PROPN
hjic-87	424	8	a.	a.	PROPN
hjic-87	424	9	:	:	PUNCT
hjic-87	424	10	drug	drug	NOUN
hjic-87	424	11	delivery	delivery	NOUN
hjic-87	424	12	tech	tech	NOUN
hjic-87	424	13	.	.	PUNCT
hjic-87	424	14	,	,	PUNCT
hjic-87	424	15	2002	2002	NUM
hjic-87	424	16	,	,	PUNCT
hjic-87	424	17	2	2	NUM
hjic-87	424	18	,	,	PUNCT
hjic-87	424	19	5	5	NUM
hjic-87	424	20	73	73	NUM
hjic-87	424	21	.	.	PUNCT
hjic-87	425	1	rogers	rogers	PROPN
hjic-87	425	2	t.	t.	PROPN
hjic-87	425	3	l.	l.	PROPN
hjic-87	425	4	,	,	PUNCT
hjic-87	425	5	johnston	johnston	PROPN
hjic-87	425	6	k.	k.	PROPN
hjic-87	425	7	p.	p.	PROPN
hjic-87	425	8	and	and	CCONJ
hjic-87	425	9	williams	williams	PROPN
hjic-87	425	10	iii	iii	PROPN
hjic-87	425	11	r.	r.	PROPN
hjic-87	425	12	o.	o.	PROPN
hjic-87	425	13	:	:	PUNCT
hjic-87	425	14	drug	drug	PROPN
hjic-87	425	15	dev	dev	PROPN
hjic-87	425	16	.	.	PUNCT
hjic-87	426	1	ind	ind	PROPN
hjic-87	426	2	.	.	PUNCT
hjic-87	427	1	pharm	pharm	PROPN
hjic-87	427	2	.	.	PUNCT
hjic-87	427	3	,	,	PUNCT
hjic-87	427	4	2001	2001	NUM
hjic-87	427	5	,	,	PUNCT
hjic-87	427	6	27(10	27(10	PROPN
hjic-87	427	7	)	)	PUNCT
hjic-87	427	8	,	,	PUNCT
hjic-87	427	9	1003	1003	NUM
hjic-87	427	10	-	-	SYM
hjic-87	427	11	1015	1015	NUM
hjic-87	427	12	74	74	NUM
hjic-87	427	13	.	.	PUNCT
hjic-87	428	1	briggs	briggs	PROPN
hjic-87	428	2	a.	a.	PROPN
hjic-87	428	3	r.	r.	PROPN
hjic-87	428	4	and	and	CCONJ
hjic-87	428	5	maxvell	maxvell	ADJ
hjic-87	428	6	t.	t.	PROPN
hjic-87	428	7	j.	j.	PROPN
hjic-87	428	8	:	:	PUNCT
hjic-87	428	9	u.s	u.s	PROPN
hjic-87	428	10	.	.	PROPN
hjic-87	428	11	pat	pat	PROPN
hjic-87	428	12	.	.	PROPN
hjic-87	428	13	3,721,725	3,721,725	NUM
hjic-87	428	14	(	(	PUNCT
hjic-87	428	15	1973	1973	NUM
hjic-87	428	16	)	)	PUNCT
hjic-87	428	17	75	75	NUM
hjic-87	428	18	.	.	PUNCT
hjic-87	429	1	briggs	briggs	PROPN
hjic-87	429	2	a.	a.	PROPN
hjic-87	429	3	r.	r.	PROPN
hjic-87	429	4	and	and	CCONJ
hjic-87	429	5	maxvell	maxvell	ADJ
hjic-87	429	6	t.	t.	PROPN
hjic-87	429	7	j.	j.	PROPN
hjic-87	429	8	:	:	PUNCT
hjic-87	429	9	u.s	u.s	PROPN
hjic-87	429	10	.	.	PROPN
hjic-87	429	11	pat	pat	PROPN
hjic-87	429	12	.	.	PROPN
hjic-87	430	1	3,928,566	3,928,566	NUM
hjic-87	430	2	(	(	PUNCT
hjic-87	430	3	1975	1975	NUM
hjic-87	430	4	)	)	PUNCT
hjic-87	430	5	76	76	NUM
hjic-87	430	6	.	.	PUNCT
hjic-87	431	1	briggs	briggs	PROPN
hjic-87	431	2	a.	a.	PROPN
hjic-87	431	3	r.	r.	PROPN
hjic-87	431	4	and	and	CCONJ
hjic-87	431	5	maxvell	maxvell	ADJ
hjic-87	431	6	t.	t.	PROPN
hjic-87	431	7	j.	j.	PROPN
hjic-87	431	8	:	:	PUNCT
hjic-87	431	9	u.s	u.s	PROPN
hjic-87	431	10	.	.	PROPN
hjic-87	431	11	pat	pat	PROPN
hjic-87	431	12	.	.	PROPN
hjic-87	431	13	3,932,943	3,932,943	NUM
hjic-87	431	14	(	(	PUNCT
hjic-87	431	15	1976	1976	NUM
hjic-87	431	16	)	)	PUNCT
hjic-87	431	17	77	77	NUM
hjic-87	431	18	.	.	PUNCT
hjic-87	432	1	adams	adams	PROPN
hjic-87	432	2	t.	t.	PROPN
hjic-87	432	3	h.	h.	PROPN
hjic-87	432	4	,	,	PUNCT
hjic-87	432	5	beck	beck	PROPN
hjic-87	432	6	j.	j.	PROPN
hjic-87	432	7	p.	p.	PROPN
hjic-87	432	8	and	and	CCONJ
hjic-87	432	9	menson	menson	VERB
hjic-87	432	10	r.	r.	PROPN
hjic-87	432	11	c.	c.	PROPN
hjic-87	432	12	:	:	PUNCT
hjic-87	432	13	u.s	u.s	PROPN
hjic-87	432	14	.	.	PROPN
hjic-87	432	15	pat	pat	PROPN
hjic-87	432	16	.	.	PROPN
hjic-87	433	1	4,211,015	4,211,015	NUM
hjic-87	433	2	(	(	PUNCT
hjic-87	433	3	1980	1980	NUM
hjic-87	433	4	)	)	PUNCT
hjic-87	433	5	78	78	NUM
hjic-87	433	6	.	.	PUNCT
hjic-87	434	1	adams	adams	PROPN
hjic-87	434	2	t.	t.	PROPN
hjic-87	434	3	h.	h.	PROPN
hjic-87	434	4	,	,	PUNCT
hjic-87	434	5	beck	beck	PROPN
hjic-87	434	6	j.	j.	PROPN
hjic-87	434	7	p.	p.	PROPN
hjic-87	434	8	and	and	CCONJ
hjic-87	434	9	menson	menson	VERB
hjic-87	434	10	r.	r.	PROPN
hjic-87	434	11	c.	c.	PROPN
hjic-87	434	12	:	:	PUNCT
hjic-87	434	13	u.s	u.s	PROPN
hjic-87	434	14	.	.	PROPN
hjic-87	434	15	pat	pat	PROPN
hjic-87	434	16	.	.	PROPN
hjic-87	434	17	4,323,478	4,323,478	NUM
hjic-87	434	18	(	(	PUNCT
hjic-87	434	19	1982	1982	NUM
hjic-87	434	20	)	)	PUNCT
hjic-87	434	21	79	79	NUM
hjic-87	434	22	.	.	PUNCT
hjic-87	435	1	hebert	hebert	PROPN
hjic-87	435	2	p.	p.	PROPN
hjic-87	435	3	f.	f.	PROPN
hjic-87	435	4	and	and	CCONJ
hjic-87	435	5	healy	healy	PROPN
hjic-87	435	6	m.	m.	PROPN
hjic-87	435	7	s.	s.	PROPN
hjic-87	435	8	:	:	PUNCT
hjic-87	436	1	u.s	u.s	PROPN
hjic-87	436	2	.	.	PROPN
hjic-87	436	3	pat	pat	PROPN
hjic-87	436	4	.	.	PROPN
hjic-87	437	1	5,922,253	5,922,253	NUM
hjic-87	437	2	(	(	PUNCT
hjic-87	437	3	1999	1999	NUM
hjic-87	437	4	)	)	PUNCT
hjic-87	437	5	80	80	NUM
hjic-87	437	6	.	.	PUNCT
hjic-87	438	1	gombotz	gombotz	PROPN
hjic-87	438	2	w.	w.	PROPN
hjic-87	438	3	r.	r.	PROPN
hjic-87	438	4	,	,	PUNCT
hjic-87	438	5	healy	healy	PROPN
hjic-87	438	6	h.	h.	PROPN
hjic-87	438	7	s.	s.	PROPN
hjic-87	438	8	and	and	CCONJ
hjic-87	438	9	brown	brown	PROPN
hjic-87	438	10	r.	r.	PROPN
hjic-87	438	11	l.	l.	PROPN
hjic-87	438	12	:	:	PUNCT
hjic-87	438	13	u.s	u.s	PROPN
hjic-87	438	14	.	.	PROPN
hjic-87	438	15	pat	pat	PROPN
hjic-87	438	16	.	.	PROPN
hjic-87	439	1	5,019,400	5,019,400	NUM
hjic-87	439	2	(	(	PUNCT
hjic-87	439	3	1991	1991	NUM
hjic-87	439	4	)	)	PUNCT
hjic-87	439	5	81	81	NUM
hjic-87	439	6	.	.	PUNCT
hjic-87	440	1	gombotz	gombotz	PROPN
hjic-87	440	2	w.	w.	PROPN
hjic-87	440	3	r.	r.	PROPN
hjic-87	440	4	,	,	PUNCT
hjic-87	440	5	healy	healy	PROPN
hjic-87	440	6	h.	h.	PROPN
hjic-87	440	7	s.	s.	PROPN
hjic-87	440	8	and	and	CCONJ
hjic-87	440	9	brown	brown	PROPN
hjic-87	440	10	r.	r.	PROPN
hjic-87	440	11	l.	l.	PROPN
hjic-87	440	12	:	:	PUNCT
hjic-87	440	13	wo	will	AUX
hjic-87	440	14	pat	pat	PROPN
hjic-87	440	15	.	.	PROPN
hjic-87	441	1	90/13285	90/13285	NUM
hjic-87	441	2	(	(	PUNCT
hjic-87	441	3	1990	1990	NUM
hjic-87	441	4	)	)	PUNCT
hjic-87	441	5	82	82	NUM
hjic-87	441	6	.	.	PUNCT
hjic-87	441	7	mumenthaler	mumenthaler	NOUN
hjic-87	441	8	m.	m.	NOUN
hjic-87	441	9	and	and	CCONJ
hjic-87	441	10	leuenberger	leuenberg	ADJ
hjic-87	441	11	h.	h.	PROPN
hjic-87	441	12	,	,	PUNCT
hjic-87	441	13	int	int	PROPN
hjic-87	441	14	.	.	PUNCT
hjic-87	442	1	j.	j.	PROPN
hjic-87	442	2	pharma	pharma	PROPN
hjic-87	442	3	.	.	PROPN
hjic-87	442	4	,	,	PUNCT
hjic-87	442	5	1991	1991	NUM
hjic-87	442	6	,	,	PUNCT
hjic-87	442	7	72	72	NUM
hjic-87	442	8	,	,	PUNCT
hjic-87	442	9	97	97	NUM
hjic-87	442	10	-	-	SYM
hjic-87	442	11	110	110	NUM
hjic-87	442	12	83	83	NUM
hjic-87	442	13	.	.	PUNCT
hjic-87	443	1	oyler	oyler	PROPN
hjic-87	443	2	j.	j.	PROPN
hjic-87	443	3	r.	r.	PROPN
hjic-87	443	4	:	:	PUNCT
hjic-87	444	1	u.s	u.s	PROPN
hjic-87	444	2	.	.	PROPN
hjic-87	444	3	pat	pat	PROPN
hjic-87	444	4	.	.	PROPN
hjic-87	444	5	5,208,998	5,208,998	NUM
hjic-87	444	6	(	(	PUNCT
hjic-87	444	7	1993	1993	NUM
hjic-87	444	8	)	)	PUNCT
hjic-87	444	9	84	84	NUM
hjic-87	444	10	.	.	PUNCT
hjic-87	445	1	sauer	sauer	PROPN
hjic-87	445	2	h.	h.	PROPN
hjic-87	445	3	a.	a.	PROPN
hjic-87	445	4	:	:	PUNCT
hjic-87	446	1	u.s	u.s	PROPN
hjic-87	446	2	.	.	PROPN
hjic-87	446	3	pat	pat	PROPN
hjic-87	446	4	.	.	PROPN
hjic-87	446	5	3,484,946	3,484,946	NUM
hjic-87	446	6	(	(	PUNCT
hjic-87	446	7	1969	1969	NUM
hjic-87	446	8	)	)	PUNCT
hjic-87	446	9	85	85	NUM
hjic-87	446	10	.	.	PUNCT
hjic-87	447	1	dunn	dunn	PROPN
hjic-87	447	2	e.	e.	PROPN
hjic-87	447	3	b.	b.	PROPN
hjic-87	447	4	,	,	PUNCT
hjic-87	447	5	masavage	masavage	PROPN
hjic-87	447	6	g.	g.	PROPN
hjic-87	447	7	j.	j.	PROPN
hjic-87	447	8	and	and	CCONJ
hjic-87	447	9	sauer	sauer	PROPN
hjic-87	447	10	h.	h.	PROPN
hjic-87	447	11	a.	a.	PROPN
hjic-87	447	12	:	:	PUNCT
hjic-87	447	13	u.s	u.s	PROPN
hjic-87	447	14	.	.	PROPN
hjic-87	447	15	pat	pat	PROPN
hjic-87	447	16	.	.	PROPN
hjic-87	447	17	3,653,222	3,653,222	NUM
hjic-87	447	18	(	(	PUNCT
hjic-87	447	19	1972	1972	NUM
hjic-87	447	20	)	)	PUNCT
hjic-87	447	21	56	56	NUM
hjic-87	447	22	86	86	NUM
hjic-87	447	23	.	.	PUNCT
hjic-87	448	1	williams	williams	PROPN
hjic-87	448	2	iii	iii	PROPN
hjic-87	448	3	r.	r.	PROPN
hjic-87	448	4	o.	o.	PROPN
hjic-87	448	5	,	,	PUNCT
hjic-87	448	6	johnston	johnston	PROPN
hjic-87	448	7	k.	k.	PROPN
hjic-87	448	8	p.	p.	PROPN
hjic-87	448	9	,	,	PUNCT
hjic-87	448	10	young	young	ADJ
hjic-87	448	11	t.	t.	PROPN
hjic-87	448	12	j.	j.	PROPN
hjic-87	448	13	,	,	PUNCT
hjic-87	448	14	rogers	rogers	PROPN
hjic-87	448	15	t.	t.	PROPN
hjic-87	448	16	l.	l.	PROPN
hjic-87	448	17	,	,	PUNCT
hjic-87	448	18	barron	barron	PROPN
hjic-87	448	19	m.	m.	PROPN
hjic-87	448	20	k.	k.	PROPN
hjic-87	448	21	and	and	CCONJ
hjic-87	448	22	yu	yu	PROPN
hjic-87	448	23	z.	z.	PROPN
hjic-87	448	24	:	:	PUNCT
hjic-87	449	1	wo	will	AUX
hjic-87	449	2	pat	pat	PROPN
hjic-87	449	3	.	.	PROPN
hjic-87	450	1	02/060411	02/060411	PROPN
hjic-87	450	2	(	(	PUNCT
hjic-87	450	3	2002	2002	NUM
hjic-87	450	4	)	)	PUNCT
hjic-87	450	5	87	87	NUM
hjic-87	450	6	.	.	PUNCT
hjic-87	451	1	rogers	rogers	PROPN
hjic-87	451	2	t.	t.	PROPN
hjic-87	451	3	l.	l.	PROPN
hjic-87	451	4	,	,	PUNCT
hjic-87	451	5	nelsen	nelsen	PROPN
hjic-87	451	6	a.	a.	PROPN
hjic-87	451	7	c.	c.	PROPN
hjic-87	451	8	,	,	PUNCT
hjic-87	451	9	hu	hu	PROPN
hjic-87	451	10	j.	j.	PROPN
hjic-87	451	11	,	,	PUNCT
hjic-87	451	12	brown	brown	PROPN
hjic-87	451	13	j.	j.	PROPN
hjic-87	451	14	n.	n.	PROPN
hjic-87	451	15	,	,	PUNCT
hjic-87	451	16	sarkati	sarkati	NOUN
hjic-87	451	17	m.	m.	NOUN
hjic-87	451	18	,	,	PUNCT
hjic-87	451	19	young	young	ADJ
hjic-87	451	20	t.	t.	PROPN
hjic-87	451	21	j.	j.	PROPN
hjic-87	451	22	,	,	PUNCT
hjic-87	451	23	johnston	johnston	PROPN
hjic-87	451	24	k.	k.	PROPN
hjic-87	451	25	p.	p.	PROPN
hjic-87	451	26	and	and	CCONJ
hjic-87	451	27	williams	williams	PROPN
hjic-87	451	28	iii	iii	PROPN
hjic-87	451	29	r.	r.	PROPN
hjic-87	451	30	o.	o.	PROPN
hjic-87	451	31	:	:	PUNCT
hjic-87	451	32	eur	eur	PROPN
hjic-87	451	33	.	.	PUNCT
hjic-87	452	1	j.	j.	PROPN
hjic-87	452	2	pharma	pharma	PROPN
hjic-87	452	3	.	.	PUNCT
hjic-87	453	1	biopharma	biopharma	PROPN
hjic-87	453	2	.	.	PUNCT
hjic-87	453	3	,	,	PUNCT
hjic-87	453	4	2002a	2002a	NUM
hjic-87	453	5	,	,	PUNCT
hjic-87	453	6	54	54	NUM
hjic-87	453	7	,	,	PUNCT
hjic-87	453	8	271	271	NUM
hjic-87	453	9	-	-	SYM
hjic-87	453	10	280	280	NUM
hjic-87	453	11	88	88	NUM
hjic-87	453	12	.	.	PUNCT
hjic-87	454	1	rogers	rogers	PROPN
hjic-87	454	2	t.	t.	PROPN
hjic-87	454	3	l.	l.	PROPN
hjic-87	454	4	,	,	PUNCT
hjic-87	454	5	hu	hu	PROPN
hjic-87	454	6	j.	j.	PROPN
hjic-87	454	7	,	,	PUNCT
hjic-87	454	8	yu	yu	PROPN
hjic-87	454	9	z.	z.	PROPN
hjic-87	454	10	,	,	PUNCT
hjic-87	454	11	johnston	johnston	PROPN
hjic-87	454	12	k.	k.	PROPN
hjic-87	454	13	p.	p.	PROPN
hjic-87	454	14	and	and	CCONJ
hjic-87	454	15	williams	williams	PROPN
hjic-87	454	16	iii	iii	PROPN
hjic-87	454	17	r.	r.	PROPN
hjic-87	454	18	o.	o.	PROPN
hjic-87	454	19	,	,	PUNCT
hjic-87	454	20	int	int	PROPN
hjic-87	454	21	.	.	PUNCT
hjic-87	455	1	j.	j.	PROPN
hjic-87	455	2	pharma	pharma	PROPN
hjic-87	455	3	.	.	PROPN
hjic-87	455	4	,	,	PUNCT
hjic-87	455	5	2002b	2002b	NUM
hjic-87	455	6	,	,	PUNCT
hjic-87	455	7	242	242	NUM
hjic-87	455	8	,	,	PUNCT
hjic-87	455	9	93	93	NUM
hjic-87	455	10	-	-	SYM
hjic-87	455	11	100	100	NUM
hjic-87	455	12	89	89	NUM
hjic-87	455	13	.	.	PUNCT
hjic-87	456	1	rogers	rogers	PROPN
hjic-87	456	2	t.	t.	PROPN
hjic-87	456	3	l.	l.	PROPN
hjic-87	456	4	,	,	PUNCT
hjic-87	456	5	overhoff	overhoff	PROPN
hjic-87	456	6	k.	k.	PROPN
hjic-87	456	7	a.	a.	PROPN
hjic-87	456	8	,	,	PUNCT
hjic-87	456	9	shah	shah	PROPN
hjic-87	456	10	p.	p.	PROPN
hjic-87	456	11	,	,	PUNCT
hjic-87	456	12	santiago	santiago	PROPN
hjic-87	456	13	p.	p.	PROPN
hjic-87	456	14	,	,	PUNCT
hjic-87	456	15	yacaman	yacaman	NOUN
hjic-87	456	16	m.	m.	PROPN
hjic-87	456	17	j.	j.	PROPN
hjic-87	456	18	,	,	PUNCT
hjic-87	456	19	johnston	johnston	PROPN
hjic-87	456	20	k.	k.	PROPN
hjic-87	456	21	p.	p.	PROPN
hjic-87	456	22	and	and	CCONJ
hjic-87	456	23	williams	williams	PROPN
hjic-87	456	24	iii	iii	PROPN
hjic-87	456	25	r.	r.	PROPN
hjic-87	456	26	o.	o.	PROPN
hjic-87	456	27	:	:	PUNCT
hjic-87	456	28	eur	eur	PROPN
hjic-87	456	29	.	.	PUNCT
hjic-87	457	1	j.	j.	PROPN
hjic-87	457	2	pharma	pharma	PROPN
hjic-87	457	3	.	.	PUNCT
hjic-87	458	1	biopharm	biopharm	PROPN
hjic-87	458	2	.	.	PUNCT
hjic-87	458	3	,	,	PUNCT
hjic-87	458	4	2003	2003	NUM
hjic-87	458	5	,	,	PUNCT
hjic-87	458	6	55	55	NUM
hjic-87	458	7	,	,	PUNCT
hjic-87	458	8	161	161	NUM
hjic-87	458	9	-	-	SYM
hjic-87	458	10	172	172	NUM
hjic-87	458	11	90	90	NUM
hjic-87	458	12	.	.	PUNCT
hjic-87	459	1	yu	yu	PROPN
hjic-87	459	2	z.	z.	PROPN
hjic-87	459	3	,	,	PUNCT
hjic-87	459	4	rogers	rogers	PROPN
hjic-87	459	5	t.	t.	PROPN
hjic-87	459	6	l.	l.	PROPN
hjic-87	459	7	,	,	PUNCT
hjic-87	459	8	hu	hu	PROPN
hjic-87	459	9	j.	j.	PROPN
hjic-87	459	10	,	,	PUNCT
hjic-87	459	11	johnston	johnston	PROPN
hjic-87	459	12	k.	k.	PROPN
hjic-87	459	13	p.	p.	PROPN
hjic-87	459	14	and	and	CCONJ
hjic-87	459	15	williams	williams	PROPN
hjic-87	459	16	iii	iii	PROPN
hjic-87	459	17	r.	r.	PROPN
hjic-87	459	18	o.	o.	PROPN
hjic-87	459	19	:	:	PUNCT
hjic-87	459	20	eur	eur	PROPN
hjic-87	459	21	.	.	PUNCT
hjic-87	460	1	j.	j.	PROPN
hjic-87	460	2	pharma	pharma	PROPN
hjic-87	460	3	.	.	PUNCT
hjic-87	461	1	biopharma	biopharma	PROPN
hjic-87	461	2	.	.	PROPN
hjic-87	461	3	,	,	PUNCT
hjic-87	461	4	2002	2002	NUM
hjic-87	461	5	,	,	PUNCT
hjic-87	461	6	54	54	NUM
hjic-87	461	7	,	,	PUNCT
hjic-87	461	8	221	221	NUM
hjic-87	461	9	-	-	SYM
hjic-87	461	10	228	228	NUM
hjic-87	461	11	91	91	NUM
hjic-87	461	12	.	.	PUNCT
hjic-87	462	1	hu	hu	PROPN
hjic-87	462	2	j.	j.	PROPN
hjic-87	462	3	,	,	PUNCT
hjic-87	462	4	johnston	johnston	PROPN
hjic-87	462	5	k.	k.	PROPN
hjic-87	462	6	p.	p.	PROPN
hjic-87	462	7	and	and	CCONJ
hjic-87	462	8	williams	williams	PROPN
hjic-87	462	9	iii	iii	PROPN
hjic-87	462	10	o.	o.	PROPN
hjic-87	462	11	r.	r.	PROPN
hjic-87	462	12	:	:	PUNCT
hjic-87	462	13	eur	eur	PROPN
hjic-87	462	14	.	.	PUNCT
hjic-87	463	1	j.	j.	PROPN
hjic-87	463	2	pharma	pharma	PROPN
hjic-87	463	3	.	.	PUNCT
hjic-87	464	1	sci	sci	PROPN
hjic-87	464	2	.	.	PROPN
hjic-87	464	3	,	,	PUNCT
hjic-87	464	4	2003	2003	NUM
hjic-87	464	5	,	,	PUNCT
hjic-87	464	6	20	20	NUM
hjic-87	464	7	,	,	PUNCT
hjic-87	464	8	295	295	NUM
hjic-87	464	9	-	-	SYM
hjic-87	464	10	303	303	NUM
hjic-87	464	11	92	92	NUM
hjic-87	464	12	.	.	PUNCT
hjic-87	465	1	hu	hu	PROPN
hjic-87	465	2	j.	j.	PROPN
hjic-87	465	3	,	,	PUNCT
hjic-87	465	4	johnston	johnston	PROPN
hjic-87	465	5	k.	k.	PROPN
hjic-87	465	6	p.	p.	PROPN
hjic-87	465	7	and	and	CCONJ
hjic-87	465	8	williams	williams	PROPN
hjic-87	465	9	iii	iii	PROPN
hjic-87	465	10	o.	o.	PROPN
hjic-87	465	11	r.	r.	PROPN
hjic-87	465	12	:	:	PUNCT
hjic-87	465	13	int	int	PROPN
hjic-87	465	14	.	.	PUNCT
hjic-87	466	1	j.	j.	PROPN
hjic-87	466	2	pharma	pharma	PROPN
hjic-87	466	3	.	.	PROPN
hjic-87	466	4	,	,	PUNCT
hjic-87	466	5	2004	2004	NUM
hjic-87	466	6	,	,	PUNCT
hjic-87	466	7	271	271	NUM
hjic-87	466	8	,	,	PUNCT
hjic-87	466	9	145	145	NUM
hjic-87	466	10	-	-	SYM
hjic-87	466	11	154	154	NUM
hjic-87	466	12	93	93	NUM
hjic-87	466	13	.	.	PUNCT
hjic-87	467	1	badens	badens	PROPN
hjic-87	467	2	e.	e.	PROPN
hjic-87	467	3	,	,	PUNCT
hjic-87	467	4	fargeot	fargeot	PROPN
hjic-87	467	5	c.	c.	PROPN
hjic-87	467	6	,	,	PUNCT
hjic-87	467	7	bosc	bosc	PROPN
hjic-87	467	8	n.	n.	PROPN
hjic-87	467	9	,	,	PUNCT
hjic-87	467	10	veesler	veesler	NOUN
hjic-87	467	11	s.	s.	PROPN
hjic-87	467	12	,	,	PUNCT
hjic-87	467	13	teillaud	teillaud	PROPN
hjic-87	467	14	e.	e.	PROPN
hjic-87	467	15	and	and	CCONJ
hjic-87	467	16	charbit	charbit	PROPN
hjic-87	467	17	g.	g.	PROPN
hjic-87	467	18	:	:	PUNCT
hjic-87	467	19	polymorph	polymorph	NOUN
hjic-87	467	20	control	control	NOUN
hjic-87	467	21	of	of	ADP
hjic-87	467	22	drug	drug	NOUN
hjic-87	467	23	in	in	ADP
hjic-87	467	24	supercritical	supercritical	ADJ
hjic-87	467	25	co2	co2	NOUN
hjic-87	467	26	,	,	PUNCT
hjic-87	467	27	european	european	ADJ
hjic-87	467	28	conference	conference	NOUN
hjic-87	467	29	on	on	ADP
hjic-87	467	30	drug	drug	NOUN
hjic-87	467	31	delivery	delivery	NOUN
hjic-87	467	32	and	and	CCONJ
hjic-87	467	33	pharmaceutical	pharmaceutical	NOUN
hjic-87	467	34	technology	technology	NOUN
hjic-87	467	35	,	,	PUNCT
hjic-87	467	36	sevilla	sevilla	PROPN
hjic-87	467	37	,	,	PUNCT
hjic-87	467	38	spain	spain	PROPN
hjic-87	467	39	may	may	AUX
hjic-87	467	40	10	10	NUM
hjic-87	467	41	-	-	SYM
hjic-87	467	42	12	12	NUM
hjic-87	467	43	,	,	PUNCT
hjic-87	467	44	2004	2004	NUM