193 | Chemistry 2016) عام 1(العدد 29المجلد مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 " New Schiff – Bases Prepared From Pyromellitic Dianhydride Via Its Hydrazide Derivative" Jinan M. Abdulrasool Emad T. Ali Jumbad H. Tomma Dept. of Chemistry / College of Education for pure science (Ibn Al- Haitham) / University of Baghdad Received in:6/September/2015,Accepted in:12/October/2015 Abstract N, N′- bis[4-hydroxy phenyl] pyromillitdiimide [II] was prepared from the corresponding diamic acid , which was transfered to its new ester by the reaction with chloroethyl acetate [III ], [III] was used to prepare the novel hydrazide derivative [IV] , which was allowed to react with several aldehydes to yield the hydrazones [V – IX]. All the new compounds were synthesized , and characterized by their melting points .HNMR for some of them1FTIR,C,H,N analysis and , Key words: hydrazide , pyromellitic dianhydride , ester , Schiff – bases. 194 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 C O O O C C O O O C NH2HO Acetone2 COOH HOOC OHCONH HO (CH3CO)2O O C C O O C C O OHHO NN CLCH2C-OCH2CH3 HNCO O C C O O C C O N N NH2-NH2-H2O Ethanol O C C O O C C O NN OCH2CNHNH2 O H2NHN-CH2CO III II CH3COONa OCH2COCH2CH3 O H3CH2OCH2CO O O XCHX CH V-IXX = ( OCH3 , N(CH3) , -CH3 , OH , -H ) Scheme 1 GAA* O Aceton I X C-H O 2 2 (glacial acetic acid ) O C C O O C C O NN OCH2CNHN= O =NHN-CH2CO O 2 IV 195 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 Introduction Pyromellitic diamic acids , imides are known to include an essential category in a wide range of applications such as , polymers , and are best known as segments of highly insulating polyimide dielectrics , they are though quit surprising that no attempt have been made to fabricate transistor from pyromellitdiimide derivatives , which have the simple aromaticring(benzene) in the center and the tetra carboxylic diimides on both sides of the benzene ring . Thus , it is possible to screen a large number of imide side chains and investigate the impact of side chains on the mobility and environmental stability of pyromellitdiimide derivatives [1,2] , inetermediate compounds to a several reactions , biological activity … etc. On other hand , hydrazides , are known to have a great deal of their biological active organic compounds [3- 7] these hydrazide and their condensation products were state to possess a wide range of biological activities as well as antibacterial activity[3] , HIVinhibitors [5] Pesticidal [6] , antifangal [7] . These hydrazides can be prepared by different methods [8,9] ; the most popular method is through their correspounding esters , by simple reaction between these esters and hydrazine hydrate[8]. Hydrazide and their different products show a wide range of biological activities , as well as , antibacterial activity [3] , HIV inhibitors [5] , pesticidal [6] , and antifungal [7] . Some of them and their corresponding hydrazones are psychopharmacological agent such as monoamine oxidase inhibitor and serotonin antagonists [10]. Hydrazide – hydrazones compounds are not only intermediates but they are also very effective organic compounds in their own right . When they are used as intermediates , a very high number of derivatives can be synthesized and formed , that is because of the presence of the active hydrogen component of [ - CONHN=CH-] azomethine (imine) group [11 – 14] . Hydrozone compounds as it was mentioned above , due to their azo methane group activities have taken an important role of many researchers in synthesizing a great numerous compounds of hydrazones by well – known hydrazinolysis method [15,16]. These compounds as well as their corresponding hydrazides found to have a wide applications in both health and medicine [17,18]. The aim of the following work is to synthesize , and characterize new hydrazide and their corresponding Schiff – bases , their characterization was done via melting points , FTIR , Their biological activity was translated HNMR for some of them ,1elemental analysis and For further works . Experimental Material :- All the chemicals were supplied from fluka , Gcc, Merck and Aldrich Chemicals Co. , and were used as received. Techniques:- FTIR spectra were recorded on a FTIR – 600 FTIR spectrometer Elemental microanalysis (C.H.N) were carried out by a(C.H.N) . in the centeral lab at HNMR spectra were carried out by 1haitham . -college of Education for ure science Ibn / Al company : bruker , model : ultra shield 300MHZ , origin : Switzerland and are reported in ppm(s) , DMSO was used as a solvent with TMS as an internal standard uncorrected melting points were determined using Hot-stage ( stmart melting point [spm 10] ) melting point apparatus. 196 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 Synthetic methods Synthesis of N ,N′-Bis(4-hydroxyphenyl) pyromellitamic diacid [I] To a solution of pyromellitic dianhydride (0.218 gm , 0.001 mole) in (15 ml) acetone , a solution of 4-hydroxy aniline (0.218 gm , 0.002 mole) in (15 ml)acetone was added dropwise during one hour , the mixture was then left at room temperature with continuous stirring for 24 hrs , the yellowish product was then obtained and filtered off , washed and recrystalized from acetone to give the corresponding N ,N′-Bis(4-hydroxyphenyl) pyromellitamic diacid [I] [19] . ).1(C. all physical properties are shown in table oYeild 90% , m.p >300 Synthesis of N, ,N′-Bis(4-hydroxyphenyl) pyromellitdiimide (II) [19] A (0.436 gm 0.001 mole) of N, ,N′-Bis(4-hydroxyphenyl)pyromellitamic diacid was placed in (50 ml) round bottom flask fitted with a condenser , a mixture of sodium acetate (0.164 gm , 0.002 mole) and acetic anhydride (3 ml) was added . The mixture was maintained between bath and stirred for one hour.The mixture was allowed to stirr –C) by means of water o 90 -(80 for 24 hrs at room temperature. Then the mixture was poured on ice-water (400ml) and filtered off , recrystalized from acetone. The physical data of N, ,N′-Bis(4-hydroxy phenyl) pyromellitdiimide are listed in table(1). Synthesis of N,N′-Bis(4-methoxy acetate phenyl)pryromellitdiimide (III) [9] [Ester] In 100 ml round bottom flask , a (0.4 gm 0.001 mole) of compound (II) , (0.006mole) soduim acetate and (0.88 gm , 0.002 mole) chloro ethyl acetate were added , 10 ml of absolute ethanol was added , then the mixture was refluxed for 5 hrs , then the selvent was removed and the ester was washed with ethanol and recystalized from ethanol . the physical properties of the new ester are listed in table(1) (yeild70%). Synthessis of the hydrazide(IV) [9] A mixture of (0.572 gm , 0.001 mole) of compound( III) and (0.072 gm , 0.002 mole) hydrazine hydrate was placed in 100 ml round bottom flask , 10 ml of absolute ethanol was added , the mixture was refluxed for 5hrs , then the solution was filtered off and the filterate was concentrated , allowed to cool at room temperature , the precipitate was filter off , recrystallized from ethanol . (yield 68%) of the hydrazide . All physical propertie are listed in table(1). The C,H,N analysis for prepared hydrazide are listed below NHC  15.443.6757.35 Calculated%  15.393.8457.73 Found    197 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 Synthesis of Schiff – bases: [V – IX] A solution of (0.002 mole) of certain aldehydes with three drops of glacial acetic acid in 10ml absolute ethanol was placed in 100 ml round bottom flask , (0.4 gm 0.001 mole) of hydrazid in 10 ml absolute ethanol was added . the mixture was allowed to reflux for 3-5 hrs , then the mixture was cooled to room temperature , filtered off and recrystallized from ethanol to get Schiff – bases [V – IX] . All physical properties are listed in table (1). C C C C OO O O NN -O CH 2 C O -N -N =C H H X CH3-O-C- O C H N N H X X= -H -CH3 -OCH3 -OH -N(CH3)2 V VI VII VIII IX Results and discussion: N, N′ - Bis(4-hydroxy phenyl) pyromellitamic diacid (I) was synthesized by the reaction of one mole of PMDA. With two moles of 4 – hydroxyl aniline in acetone as a solvent [20]. The reaction mechanism involves nucloophilic addition , as follows scheme (2) . HO- C C c C O O O OO HO- C C C C O OO O N H H -OH N H H O O Proton Exchance C C C C OO O O OH HO HO- -N H N H -OH HO- I Scheme 2 NH3 o NH3 198 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 The characterization of N,N′ - Bis(4- hydroxyphenyl) pyromellitamic diacid was by its melting point . and FTIR , FTIR spectra show the disappearance of absorption -group and other characterizing peaks due to anhydride ring of 4 2bands due to NH hydroxyl aniline and PMDA respecivly , with appearance of new absorption stretching , C=O 1-3248 ) cm-bands due to OH of carboxylic and phenolic groups at (3217 . 1 -, C=O (amid) stretching at ( 1643 ) cm 1-at(1705 ) cm (carboxylic acid) stretching the FTIR data obtained support the proposed structure. N,N′ - Bis(4-hydroxy phenyl) pyromellitdiimide (II) was synthesized by the intra molecular cyclization reaction of the prepared diamic acid (I) using acetic anhydride – C) . The mechanism of o90-sodium acetate system [20] as a dehydrating agent at (80 the cyclization involves neucleophilic substitution reaction This compound (II) was characterized by its melting point , FTIR spectroscopy [21]. The FTIR spectrum shows the disappearance of stretching absorption bands of NH , OH and C=O (amide and carboxylic acid moiety) groups of compound (I) , and the , which due to the 1 -1770 ) cm -appearance of two peaks in the region ( 1718 stretching vibration of the C=O (cyclic imide) and , also two absorption bands at about 21] , also C (cyclic) [-N -)symmetrical and asymmetrical C 1-)and (713 cm1 -(1132 cm ) , these FTIR data fit with the 1-the phenolic (OH) group appeared at (3323 cm .proposed compound (II) N,N′-Bis –(4- ethyl acetoxy phenyl) pyromillidiimide (III) [9]. The phenolic group attached to the prepared diimide was converted to new ester by the reaction of compound (II) with ethylchloroacetate in a basic medium , by nucleophilic subsititution reactions ,the etheylcholoroacetate and the diimidic phenol form the new ester (III) , in which the phenoxide ion replaced the halogen of the ethyl chloro acetate to form the etheric ester , according to the following scheme . 199 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 200 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 The prepared ester was identified by its melting point,FTIR spectrum , which shows the disappearance of phenolic hydrogen (-OH) and the appearance of [-COO- H) aliph. -) due to (C 1 -) , and the peak at (2927 cm 1 -ester group at (1442 cm] moiety. The following structure was proposed to the prepared ester . Preparation of the hydrazide (IV) . [9] The prerpared ester was converted to the correspounding hydrazide by the reaction with hydrazine hydrate (80%) in ethanol as a solvent . The reaction between the hydrazine and the ester is a simple nucleophilic subsititution reaction mehanism at the carbon of the carbonyl group , by which an unstable intermediate will be formed , which lose a good leaving group (ethoxide group) to form the hydrazide as a final product . as shown in the following mechanism. (schem 4) . The final product was identified by its crystal shape and its melting point , FTIR , C,H,N analysis and HNMR spectrum. H setrtching -) due the N 1-cm The FTIR results show a sharp peak at ( 3172 group,and a band at 2due to NH )1 -) and (3340 cm1 -freqancy , and at (3282 cm ) due to the C=O group , this band was observed to be in lower frequency 1-(1697cm compared to that found in C=O group of the ester due to the resonance phenomena in the hydrazide moiety which lead to reduce the double bond order of (C=O) group and then to reduce the force constant of the bond , so that its frequency will be , then , reduced too [21]. 201 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 The HNMR data Figure (1) for the hydrazide (IV) shows the following signals:- groups at δ 8.425 2Four protons of CH Ten protons of (aromatic ring protons ) at δ 6.39 – 6.48 Two protons of NH (group) at δ 2.5 (groups) at δ 2.2 2Four protons of NH These results (m.p , FTIR , C,H,N and HNMR ) are fit with the proposed structure (IV). Finally the formation of Schiff bases (V-IX) which were prepared by the reaction of one mole of the prepared hydrazide with two moles of certai aromatic aldehydes to form the new Schiff – bases in the acidic medium and follows the following mechanism . Schem (5) . Schiff – bases were idenfied by their melting points FTIR ,C,H,N – analysis and HNMR for some of them. The FTIR spectra , show the diappearnace of C=O group of the aldehydes used , and the formation of C=N at frequencies ranges -( 735 C bond of the hydrazone moiety at-N-, also the C 1 -cm) 1658- 1606( 1618 ) -, and finally the C=C aromatic bonds which appeared at (1435 1 -cm) 1130 .which may interfere with C=C groups 1 -cm The C,H,N- analysis shows the following results in the (table2). The HNMR shows the following data [21] Figure (2). Two protons of CH= N (imin protons) at δ 9.4 (groups) at δ 3.8 3Six proton of OCH Two protons of NH (groups) at δ 2.5 (groups) at δ 8.515 2Four protons of CH Eighteen protons of aromaticring protons at δ 6.2 – 7.85 202 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 From the above data we can conclude that all the structure of the prepared Schiff – bases fit with the proposed one . The formation of the new Schiff – bases derivatives which was affected by the presence of attracting or repulling groups attached to the phenyl moiety of the aldehdes was translated for further research works[22]. References 1-Sharma , P. ; Kukreja , P. ; Choudhary , V. and Narula , A . (2005) Curing and Thermal Behavior of Epoxy Resin in the Presence of Aromatic Imides – Amines , ind.J . of engine . and Mat. Sci; , 12 : 259 – 264. 2-lee , S. ; Shin , G. ; Chi, J. ; Zin , W. ; Jung, J. ; Hahm , S. ; Ree , M. and Chang , T. (2006) Synthesis , Characterization and liquid – crystal Aligining properties of Novel aromatic polypyromellitimides bearing (n – alkyloxy) biphenyloxy side chains , polymer , 47(19 ) : 6606 – 6621. 3-Rollas , S. ; Gulerman , N. and Erdeniz , H. (2000) Synthesis and Antimicrobial activity of some new hydrazones of 4-Fluorobenzioe acid hydrazide and 3-acetyl – 2 ,5 – disubstituted – 1,2,3 – oxadiazolines. Farma Co , 57 ; (2) : 171 – 174 4-Pavan , F. ; Maia , R. ; and Leite , S.(2010) , Thiosemi Carbazones , Semicarbazones , dithiocarbazate , and hydrazide / hydrazones : Anti – Mycobacterium tuberculosis activity and cytotoxicity . Eur.J. Med Chem. , 45 ; (5) : 1898 – 1905. 5-Marastoni , M. ; Baldisserotto , A. ; Trapelle , C. ; McDonald , J. ; Bortolotti , F. and Tomatis R. (2005) HIV protease inhibitor : synthesis and activity of N-aryl - N′ - hydroxyalky hydrazide Pseudopeptides . Eur – J.Med. Chem. ,40 (5) ; 445 – 451. 6-Tabanca , N. ; Ali , A. and Bernier , UR.(2013) Biting deterrence and insecticidal activity of hydrazide – hydrazones and their corresponding 3- acetyl – b3 , 5-disubstituted – 2, 3 – dihydro – 1,3,4 – oxxa-diozoles against Aedes aegypti. Pest Manag Sci. , 69 ;(6) 703 – 708. 7-Turan – Zitounti , G. ; Altintop , MD. ; Ozdemir , A. ; Demirci , F. ; Mohsen , UA. And Kaplancikli , ZA. (2012) Synthesis and Antifangal activity of new hydrazide derivatives. J. Enzym Inhib.Med. chem.. ; 55 ; (3). 8-Aymen Nabeel Yaseen.(2005) ; M.Sc. Thesis submitted to College of Education for Pure Science , University of Mosul. 9-Karam , N. ; Tomma , J. and Al-dujalli , A. (2013) " Synthesis and Characterization of Heterocyclic compounds Derived from 4-hydrox and 4-amino Acetophenone . Ibn Al- Haithum J. for pure and applied Sci – (36) 3 , 28 - 34. 10-Ashish , K. ; and JKM. (2012) A Highly Efficient Solvent free synthesis of hydrazides Using Grinding Technique , An Int. Q.J. Heterocycles. , 2 ; (4) :401 -404. 11-Rollas , S. ; and Kuckgzel , SG . (2007) Biological activities of hydrazone derivates. Molecules. , 12;(8) :1910 – 1939. 12-Kobayashi , M. ; Goda , M. ; and shimizu , S. (1999) Hydrazide synthesis : novel substrate specificity of amidase. Biochem Biophys Res comman. , 256 ; (2):415 – 418. 203 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 13-Hanumanagoud , H. ; and Basavaraja K.M. (2013) Synthesis and evaluation of some new oxadiazole and pyrazole derivatives incorporating benzofuran moiety . Der pharma Chem. , 5 ;(4) :87 – 98. 14-Mohammad , S. ; and Aymen , N. (2015) Synthesis and characterization of some new Hydrazides and their Derivatives . Ibn Al-Haitham Journal for Pure and Applied Sceince , (in press). 15-Zabivky , J. (1970) "the chemistry of Amides" John wiley and sons ltd. 16-Govindasami T. (2011) Synthesis , characterization and Antibacterial Activity of Biologically Important Vanillin related to hydrazone derivatives. Int. J. Org . chem. , 1 ; (9): 71-77. 17-Bernardino AMR. ; Gomes , AO. ; and charred Ks. (2006) Synthesis and Leishmanicidal Activities of 1-(4-X-phenyl)-N′-[(4-Y-phenyl)methelen]-1H-Parazole-4- Carbohyrazides. Chem. Inform. , 37 ; (27) 18-Turan-Zitouni G. ; Altintop , MD. ; Ozdemir A. ; Demirci F. ; Mohsen UA. ; and Kaplancikli ZA. (2013) Synthesis and Antifungal activity of new hydrazide derivatives. J. Enzym Inhib.Med. chem. , 28 ; (6) , 1211-1216 . 19-Ali , E. ; Aliawy , K. and Tomma , J. (2011) " Synthesis and Characterization of New Symmetrical pyromellitdiimide Derivatives and their Amic Acids " Ibn Al-Haithum J. for Pure and Applied Science , 24(3) :1-11. 20-Awad , W. ; and Ali , E. (1976) Synthesis of Some Pyromellillitic Acids , Pyromellitdiimides and Iso – imides" . Iraqi J. of Chem. (2), 88-94. 21-Silverstein , R.M. ; Webster , F. X. ; and Kiemle, D.J. (2005) ("Identification of ., Eddition thOrganic compounds") John Wiley and Sons , Inc. 7 22-Zahmathesh , S. and Vakili , M. R. (2010) " Synthesis and Characterization of New Optically Active Poly(ethyl –L-lysinamides and poly(ethyl – L-(ysinimide)s , J of Amino acids , 1-6.   Table ( 1 ):The physical properties of the prepared compounds Recrystalization solvent yield CoPoint Melting Color The name of the compound Compound No. acetone 90% 300> yellow [2,5-bis(4-hydroxy phenyl carbomoyl)terphthalic acid] I acetone 80% 300> deep yellow [2,6-bis(4-hydroxy phenyl)pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetraone II ethanol 70% 300> Pale light [Ethyl 2-(4-(6-4-((ethoxy carbonyloxy))methyl)phenyl)-1,3,5,7,tetraoxo-6,7- dihydro pyrrolo[3,4-f]isoindole(-2(1H,3H,5H)-yl)phenoxy acetate] III ethanol 75% (187-189) orange [4-(6-(4-(2-hydrazinyl-2-oxoethoxy phenyl)-1,3,5,7-tetraoxo-6,7-dihydro pyrrolo[3,4-f]isoindole 2(H,3H,5H)-yl)benzo hydrazide] IV ethanol 76% (190-192) grey [2,2'-(4,4'-(1,3,5,7-tetreoxo pyrrolo[3,4-f]isoindole-2,6(1H,3H,5H,7H)- diyl)bis(4,1-phenylene)bis(oxy)bis(N'-benzylideneaceto hydrazide] V benzene 76% (207-209) yellowish-grey [2,2'-(4,4'-(1,3,5,7-tetreoxo pyrrolo[3,4-f]isoindole-2,6(1H,3H,5H,7H)- diyl)bis(4,1-phenylene)bis(oxy)bis(N'-(4-methyl)benzylideneaceto hydrazide] VI benzene 76% (238-240) deep yellow [2,2'-(4,4'-(1,3,5,7-tetreoxo pyrrolo[3,4-f]isoindole-2,6(1H,3H,5H,7H)- diyl)bis(4,1-phenylene)bis(oxy)bis(N'-(4-methoxy)benzylideneaceto hydrazide] VII ethanol 70% >>300 yellowish-red [2,2'-(4,4'-(1,3,5,7-tetreoxo pyrrolo[3,4-f]isoindole-2,6(1H,3H,5H,7H)- diyl)bis(4,1-phenylene)bis(oxy)bis(N'-(4-hydroxy)benzylideneaceto hydrazide] VIII ethanol 70% 250 deep orange [2,2'-(4,4'-(1,3,5,7-tetreoxo pyrrolo[3,4-f]isoindole-2,6(1H,3H,5H,7H)- diyl)bis(4,1-phenylene)bis(oxy)bis(N'-(4-amino di methy)benzylideneaceto hydrazide] IX 205 | Chemistry 2016) عام 1(العدد 29المجلد مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 Table (2): The C, H, N analysis of the prepared Schiff - bases N % H % C % Molecular formula Compound No. 11.66 11.56 3.88 3.90 66.66 66.18 Cal. found 8O6N28H40C (V) R =H 11.22 11.10 4.27 4.22 67.37 67.03 Cal. found 8O6N32H42C (VI) R = CH3 10.76 10.61 4.10 4.59 64.61 64.33 Cal. found 10O6N32H42C VII) R= OCH3( 11.17 10.98 3.72 3.77 63.82 63.69 Cal. found 10O6N28H40C VIII) R= OH( 13.89 13.78 4.71 4.67 65.50 66.08 Cal. found 8O8N38H44C IX) R = 2N(CH3)(   206 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 HNMR for the hydrazide compound[IV] 207 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 HNMR for the compound [VII] 208 | Chemistry 2016) عام 1(العدد 29لمجلد ا مجلة إبن الهيثم للعلوم الصرفة و التطبيقية Ibn Al-Haitham Jour. for Pure & Appl. Sci. Vol. 29 (1) 2016 تحضير قواعد شف جديدة مشتقة من انهدريد البايروملتيك ومن خالل مشتقات الهيدرازايد جنان محسن عبدالرسول تقي علي عماد هرمز توما جمبد ابن الهيثم) / جامعة بغدادالصرفة (كلية التربية للعلوم /قسم الكيمياء 2015تشرين األول//12،قبل في: 2015أيلول//6استلم في: الخالصة (ثنائي اميك) , اذ ) من الحوامض المقابله له IIبايرومليتا داي ايميد ( ]هيدروكسي فينيل -4[ثنائي - N′,Nتم تحضير ) استعمل تحضير III) . وهذا االستر االخير(IIIتم تحويله الى االستر الجديد من خالل تفاعله مع اثيل كلورواسيتيت ( ) بمفاعلته مع الهايدرازين المائي بوجود الكحول كمذيب , تم مفاعله مجموعة من الديهايدات IVالهيدرازيد الجديد ( ).V-IXالمحضر لتحضير قواعد شف الجديدة ( اوروماتية مع الهيدرازيد شخصت جميع المركبات المحضرة الجديدة من خالل درجات االنصهار , واالشعة تحت الحمراء وتحليل العناصر الدقيق والرنين النووي المغناطيسي للبعض منها اذ وجد من نتائج التحليل تطابق التراكيب المقترحة. .الهيدرازايد , انهدريد البايرومليتاميك , االسترات , وقواعد شف: الكلمات المفتاحية