id	sid	tid	token	lemma	pos
iajs-2271	1	1	1	1	NUM
iajs-2271	1	2	ibn	ibn	PROPN
iajs-2271	1	3	al	al	PROPN
iajs-2271	1	4	-	-	PUNCT
iajs-2271	1	5	haitham	haitham	PROPN
iajs-2271	1	6	jour	jour	X
iajs-2271	1	7	.	.	PROPN
iajs-2271	1	8	for	for	ADP
iajs-2271	1	9	pure	pure	ADJ
iajs-2271	1	10	&	&	CCONJ
iajs-2271	1	11	appl	appl	PROPN
iajs-2271	1	12	.	.	PUNCT
iajs-2271	2	1	sci	sci	PROPN
iajs-2271	2	2	.	.	PROPN
iajs-2271	2	3	32	32	NUM
iajs-2271	2	4	(	(	PUNCT
iajs-2271	2	5	3	3	NUM
iajs-2271	2	6	)	)	PUNCT
iajs-2271	2	7	2019	2019	NUM
iajs-2271	2	8	khayatt	khayatt	PROPN
iajs-2271	2	9	b.	b.	PROPN
iajs-2271	2	10	i.	i.	PROPN
iajs-2271	2	11	abstract	abstract	PROPN
iajs-2271	2	12	the	the	DET
iajs-2271	2	13	efficient	efficient	ADJ
iajs-2271	2	14	sequencing	sequencing	NOUN
iajs-2271	2	15	techniques	technique	NOUN
iajs-2271	2	16	have	have	AUX
iajs-2271	2	17	significantly	significantly	ADV
iajs-2271	2	18	increased	increase	VERB
iajs-2271	2	19	the	the	DET
iajs-2271	2	20	number	number	NOUN
iajs-2271	2	21	of	of	ADP
iajs-2271	2	22	genomes	genome	NOUN
iajs-2271	2	23	that	that	PRON
iajs-2271	2	24	are	be	AUX
iajs-2271	2	25	now	now	ADV
iajs-2271	2	26	available	available	ADJ
iajs-2271	2	27	,	,	PUNCT
iajs-2271	2	28	including	include	VERB
iajs-2271	2	29	the	the	DET
iajs-2271	2	30	crenarchaeon	crenarchaeon	PROPN
iajs-2271	2	31	sulfolobus	sulfolobus	NOUN
iajs-2271	2	32	solfataricus	solfataricus	ADJ
iajs-2271	2	33	p2	p2	NOUN
iajs-2271	2	34	genome	genome	NOUN
iajs-2271	2	35	.	.	PUNCT
iajs-2271	3	1	the	the	DET
iajs-2271	3	2	genome	genome	NOUN
iajs-2271	3	3	-	-	PUNCT
iajs-2271	3	4	scale	scale	NOUN
iajs-2271	3	5	metabolic	metabolic	NOUN
iajs-2271	3	6	pathways	pathway	NOUN
iajs-2271	3	7	in	in	ADP
iajs-2271	3	8	sulfolobus	sulfolobus	ADJ
iajs-2271	3	9	solfataricus	solfataricus	ADJ
iajs-2271	3	10	p2	p2	NOUN
iajs-2271	3	11	were	be	AUX
iajs-2271	3	12	predicted	predict	VERB
iajs-2271	3	13	by	by	ADP
iajs-2271	3	14	implementing	implement	VERB
iajs-2271	3	15	the	the	DET
iajs-2271	3	16	“	"	PUNCT
iajs-2271	3	17	pathway	pathway	NOUN
iajs-2271	3	18	tools	tool	NOUN
iajs-2271	3	19	”	"	PUNCT
iajs-2271	3	20	software	software	NOUN
iajs-2271	3	21	using	use	VERB
iajs-2271	3	22	metacyc	metacyc	NOUN
iajs-2271	3	23	database	database	NOUN
iajs-2271	3	24	as	as	ADP
iajs-2271	3	25	reference	reference	NOUN
iajs-2271	3	26	knowledge	knowledge	NOUN
iajs-2271	3	27	base	base	NOUN
iajs-2271	3	28	.	.	PUNCT
iajs-2271	4	1	a	a	DET
iajs-2271	4	2	pathway	pathway	NOUN
iajs-2271	4	3	/	/	SYM
iajs-2271	4	4	genome	genome	NOUN
iajs-2271	4	5	data	data	NOUN
iajs-2271	4	6	base	base	NOUN
iajs-2271	4	7	(	(	PUNCT
iajs-2271	4	8	pgdb	pgdb	NOUN
iajs-2271	4	9	)	)	PUNCT
iajs-2271	4	10	specific	specific	ADJ
iajs-2271	4	11	for	for	ADP
iajs-2271	4	12	sulfolobus	sulfolobus	ADJ
iajs-2271	4	13	solfataricus	solfataricus	ADJ
iajs-2271	4	14	p2	p2	NOUN
iajs-2271	4	15	was	be	AUX
iajs-2271	4	16	created	create	VERB
iajs-2271	4	17	.	.	PUNCT
iajs-2271	5	1	a	a	DET
iajs-2271	5	2	curation	curation	NOUN
iajs-2271	5	3	approach	approach	NOUN
iajs-2271	5	4	was	be	AUX
iajs-2271	5	5	carried	carry	VERB
iajs-2271	5	6	out	out	ADP
iajs-2271	5	7	regarding	regard	VERB
iajs-2271	5	8	all	all	DET
iajs-2271	5	9	the	the	DET
iajs-2271	5	10	amino	amino	ADJ
iajs-2271	5	11	acids	acid	NOUN
iajs-2271	5	12	biosynthetic	biosynthetic	ADJ
iajs-2271	5	13	pathways	pathway	NOUN
iajs-2271	5	14	.	.	PUNCT
iajs-2271	6	1	experimental	experimental	ADJ
iajs-2271	6	2	literatures	literature	NOUN
iajs-2271	6	3	as	as	ADV
iajs-2271	6	4	well	well	ADV
iajs-2271	6	5	as	as	ADP
iajs-2271	6	6	homology-	homology-	NOUN
iajs-2271	6	7	,	,	PUNCT
iajs-2271	6	8	orthologyand	orthologyand	NOUN
iajs-2271	6	9	context	context	NOUN
iajs-2271	6	10	-	-	PUNCT
iajs-2271	6	11	based	base	VERB
iajs-2271	6	12	protein	protein	NOUN
iajs-2271	6	13	function	function	NOUN
iajs-2271	6	14	prediction	prediction	NOUN
iajs-2271	6	15	methods	method	NOUN
iajs-2271	6	16	were	be	AUX
iajs-2271	6	17	followed	follow	VERB
iajs-2271	6	18	for	for	ADP
iajs-2271	6	19	the	the	DET
iajs-2271	6	20	curation	curation	NOUN
iajs-2271	6	21	process	process	NOUN
iajs-2271	6	22	.	.	PUNCT
iajs-2271	7	1	the	the	DET
iajs-2271	7	2	“	"	PUNCT
iajs-2271	7	3	pathologic	pathologic	ADJ
iajs-2271	7	4	”	"	PUNCT
iajs-2271	7	5	component	component	NOUN
iajs-2271	7	6	of	of	ADP
iajs-2271	7	7	the	the	DET
iajs-2271	7	8	“	"	PUNCT
iajs-2271	7	9	pathway	pathway	NOUN
iajs-2271	7	10	tools	tool	NOUN
iajs-2271	7	11	”	"	PUNCT
iajs-2271	7	12	programme	programme	NOUN
iajs-2271	7	13	was	be	AUX
iajs-2271	7	14	able	able	ADJ
iajs-2271	7	15	to	to	PART
iajs-2271	7	16	predict	predict	VERB
iajs-2271	7	17	many	many	ADJ
iajs-2271	7	18	amino	amino	ADJ
iajs-2271	7	19	acid	acid	NOUN
iajs-2271	7	20	biosynthetic	biosynthetic	ADJ
iajs-2271	7	21	metabolic	metabolic	NOUN
iajs-2271	7	22	pathways	pathway	NOUN
iajs-2271	7	23	.	.	PUNCT
iajs-2271	8	1	the	the	DET
iajs-2271	8	2	total	total	ADJ
iajs-2271	8	3	number	number	NOUN
iajs-2271	8	4	of	of	ADP
iajs-2271	8	5	the	the	DET
iajs-2271	8	6	metabolic	metabolic	NOUN
iajs-2271	8	7	pathways	pathway	NOUN
iajs-2271	8	8	was	be	AUX
iajs-2271	8	9	modified	modify	VERB
iajs-2271	8	10	to	to	ADP
iajs-2271	8	11	168	168	NUM
iajs-2271	8	12	pathways	pathway	NOUN
iajs-2271	8	13	by	by	ADP
iajs-2271	8	14	adding	add	VERB
iajs-2271	8	15	extra	extra	ADJ
iajs-2271	8	16	pathways	pathway	NOUN
iajs-2271	8	17	that	that	PRON
iajs-2271	8	18	have	have	AUX
iajs-2271	8	19	not	not	PART
iajs-2271	8	20	been	be	AUX
iajs-2271	8	21	detected	detect	VERB
iajs-2271	8	22	by	by	ADP
iajs-2271	8	23	the	the	DET
iajs-2271	8	24	“	"	PUNCT
iajs-2271	8	25	pathologic	pathologic	NOUN
iajs-2271	8	26	”	"	PUNCT
iajs-2271	8	27	.	.	PUNCT
iajs-2271	9	1	amino	amino	NOUN
iajs-2271	9	2	acid	acid	PROPN
iajs-2271	9	3	biosynthetic	biosynthetic	ADJ
iajs-2271	9	4	pathways	pathway	NOUN
iajs-2271	9	5	such	such	ADJ
iajs-2271	9	6	as	as	ADP
iajs-2271	9	7	alpha	alpha	NOUN
iajs-2271	9	8	-	-	PUNCT
iajs-2271	9	9	aminoadipic	aminoadipic	ADJ
iajs-2271	9	10	acid	acid	NOUN
iajs-2271	9	11	(	(	PUNCT
iajs-2271	9	12	aaa	aaa	NOUN
iajs-2271	9	13	)	)	PUNCT
iajs-2271	9	14	pathway	pathway	NOUN
iajs-2271	9	15	of	of	ADP
iajs-2271	9	16	lysine	lysine	NOUN
iajs-2271	9	17	biosynthesis	biosynthesis	NOUN
iajs-2271	9	18	and	and	CCONJ
iajs-2271	9	19	alanine	alanine	NOUN
iajs-2271	9	20	biosynthesis	biosynthesis	VERB
iajs-2271	9	21	as	as	ADV
iajs-2271	9	22	well	well	ADV
iajs-2271	9	23	as	as	ADP
iajs-2271	9	24	the	the	DET
iajs-2271	9	25	super	super	NOUN
iajs-2271	9	26	-	-	NOUN
iajs-2271	9	27	pathway	pathway	NOUN
iajs-2271	9	28	of	of	ADP
iajs-2271	9	29	phenylalanine	phenylalanine	NOUN
iajs-2271	9	30	,	,	PUNCT
iajs-2271	9	31	tyrosine	tyrosine	NOUN
iajs-2271	9	32	and	and	CCONJ
iajs-2271	9	33	tryptophan	tryptophan	NOUN
iajs-2271	9	34	biosynthesis	biosynthesis	NOUN
iajs-2271	9	35	variation	variation	NOUN
iajs-2271	9	36	ii	ii	NOUN
iajs-2271	9	37	were	be	AUX
iajs-2271	9	38	added	add	VERB
iajs-2271	9	39	to	to	ADP
iajs-2271	9	40	the	the	DET
iajs-2271	9	41	pathway	pathway	NOUN
iajs-2271	9	42	/	/	SYM
iajs-2271	9	43	genome	genome	NOUN
iajs-2271	9	44	data	datum	NOUN
iajs-2271	9	45	base	base	NOUN
iajs-2271	9	46	of	of	ADP
iajs-2271	9	47	sulfolobus	sulfolobus	NOUN
iajs-2271	9	48	solfataricus	solfataricus	ADJ
iajs-2271	9	49	p2	p2	NOUN
iajs-2271	9	50	.	.	PUNCT
iajs-2271	10	1	discovery	discovery	NOUN
iajs-2271	10	2	of	of	ADP
iajs-2271	10	3	the	the	DET
iajs-2271	10	4	missing	miss	VERB
iajs-2271	10	5	enzymes	enzyme	NOUN
iajs-2271	10	6	that	that	PRON
iajs-2271	10	7	have	have	VERB
iajs-2271	10	8	to	to	PART
iajs-2271	10	9	fill	fill	VERB
iajs-2271	10	10	in	in	ADP
iajs-2271	10	11	the	the	DET
iajs-2271	10	12	metabolic	metabolic	NOUN
iajs-2271	10	13	holes	hole	NOUN
iajs-2271	10	14	in	in	ADP
iajs-2271	10	15	the	the	DET
iajs-2271	10	16	pathways	pathway	NOUN
iajs-2271	10	17	under	under	ADP
iajs-2271	10	18	study	study	NOUN
iajs-2271	10	19	was	be	AUX
iajs-2271	10	20	the	the	DET
iajs-2271	10	21	main	main	ADJ
iajs-2271	10	22	curation	curation	NOUN
iajs-2271	10	23	task	task	NOUN
iajs-2271	10	24	.	.	PUNCT
iajs-2271	11	1	this	this	DET
iajs-2271	11	2	approach	approach	NOUN
iajs-2271	11	3	and	and	CCONJ
iajs-2271	11	4	the	the	DET
iajs-2271	11	5	curated	curate	VERB
iajs-2271	11	6	amino	amino	NOUN
iajs-2271	11	7	acid	acid	NOUN
iajs-2271	11	8	biosynthetic	biosynthetic	ADJ
iajs-2271	11	9	pathways	pathway	NOUN
iajs-2271	11	10	in	in	ADP
iajs-2271	11	11	the	the	DET
iajs-2271	11	12	pgdb	pgdb	NOUN
iajs-2271	11	13	of	of	ADP
iajs-2271	11	14	sulfolobus	sulfolobus	NOUN
iajs-2271	11	15	solfataricus	solfataricus	ADJ
iajs-2271	11	16	p2	p2	NOUN
iajs-2271	11	17	can	can	AUX
iajs-2271	11	18	be	be	AUX
iajs-2271	11	19	used	use	VERB
iajs-2271	11	20	for	for	ADP
iajs-2271	11	21	genomic	genomic	ADJ
iajs-2271	11	22	annotations	annotation	NOUN
iajs-2271	11	23	and	and	CCONJ
iajs-2271	11	24	metabolic	metabolic	NOUN
iajs-2271	11	25	pathway	pathway	NOUN
iajs-2271	11	26	reconstructions	reconstruction	NOUN
iajs-2271	11	27	of	of	ADP
iajs-2271	11	28	closely	closely	ADV
iajs-2271	11	29	related	relate	VERB
iajs-2271	11	30	bacteria	bacteria	NOUN
iajs-2271	11	31	and	and	CCONJ
iajs-2271	11	32	archaea	archaea	NOUN
iajs-2271	11	33	.	.	PUNCT
iajs-2271	12	1	keywords	keyword	NOUN
iajs-2271	12	2	:	:	PUNCT
iajs-2271	12	3	crenarchaeon	crenarchaeon	NOUN
iajs-2271	12	4	,	,	PUNCT
iajs-2271	12	5	pathway	pathway	NOUN
iajs-2271	12	6	tools	tool	NOUN
iajs-2271	12	7	,	,	PUNCT
iajs-2271	12	8	amino	amino	ADJ
iajs-2271	12	9	acid	acid	NOUN
iajs-2271	12	10	biosynthesis	biosynthesis	NOUN
iajs-2271	12	11	,	,	PUNCT
iajs-2271	12	12	metabolic	metabolic	NOUN
iajs-2271	12	13	pathways	pathway	NOUN
iajs-2271	12	14	reconstruction	reconstruction	NOUN
iajs-2271	12	15	,	,	PUNCT
iajs-2271	12	16	protein	protein	NOUN
iajs-2271	12	17	function	function	NOUN
iajs-2271	12	18	prediction	prediction	NOUN
iajs-2271	12	19	.	.	PUNCT
iajs-2271	13	1	(	(	PUNCT
iajs-2271	13	2	supplementary	supplementary	ADJ
iajs-2271	13	3	figures	figure	NOUN
iajs-2271	13	4	can	can	AUX
iajs-2271	13	5	be	be	AUX
iajs-2271	13	6	found	find	VERB
iajs-2271	13	7	at	at	ADP
iajs-2271	13	8	:	:	PUNCT
iajs-2271	13	9	https://figshare.com/s/8bea91e91cb6ce193fee	https://figshare.com/s/8bea91e91cb6ce193fee	NOUN
iajs-2271	13	10	)	)	PUNCT
iajs-2271	13	11	1	1	NUM
iajs-2271	13	12	.	.	PUNCT
iajs-2271	13	13	introduction	introduction	NOUN
iajs-2271	13	14	ribosomal	ribosomal	NOUN
iajs-2271	13	15	rna	rna	PROPN
iajs-2271	13	16	phylogenetic	phylogenetic	ADJ
iajs-2271	13	17	analysis	analysis	NOUN
iajs-2271	13	18	,	,	PUNCT
iajs-2271	13	19	translation	translation	NOUN
iajs-2271	13	20	,	,	PUNCT
iajs-2271	13	21	transcription	transcription	NOUN
iajs-2271	13	22	,	,	PUNCT
iajs-2271	13	23	and	and	CCONJ
iajs-2271	13	24	replication	replication	NOUN
iajs-2271	13	25	-	-	PUNCT
iajs-2271	13	26	involving	involve	VERB
iajs-2271	13	27	protein	protein	NOUN
iajs-2271	13	28	studies	study	NOUN
iajs-2271	13	29	positioned	position	VERB
iajs-2271	13	30	archaea	archaea	NOUN
iajs-2271	13	31	as	as	ADP
iajs-2271	13	32	a	a	DET
iajs-2271	13	33	distinct	distinct	ADJ
iajs-2271	13	34	domain	domain	NOUN
iajs-2271	13	35	with	with	ADP
iajs-2271	13	36	bacteria	bacteria	NOUN
iajs-2271	13	37	and	and	CCONJ
iajs-2271	13	38	eukarya	eukarya	NOUN
iajs-2271	13	39	.	.	PUNCT
iajs-2271	14	1	being	be	AUX
iajs-2271	14	2	distanced	distance	VERB
iajs-2271	14	3	from	from	ADP
iajs-2271	14	4	either	either	DET
iajs-2271	14	5	bacteria	bacteria	NOUN
iajs-2271	14	6	or	or	CCONJ
iajs-2271	14	7	eukaryotes	eukaryote	NOUN
iajs-2271	14	8	does	do	AUX
iajs-2271	14	9	not	not	PART
iajs-2271	14	10	mean	mean	VERB
iajs-2271	14	11	the	the	DET
iajs-2271	14	12	absence	absence	NOUN
iajs-2271	14	13	of	of	ADP
iajs-2271	14	14	common	common	ADJ
iajs-2271	14	15	features	feature	NOUN
iajs-2271	14	16	among	among	ADP
iajs-2271	14	17	these	these	DET
iajs-2271	14	18	life	life	NOUN
iajs-2271	14	19	domains	domain	NOUN
iajs-2271	14	20	.	.	PUNCT
iajs-2271	15	1	it	it	PRON
iajs-2271	15	2	has	have	AUX
iajs-2271	15	3	been	be	AUX
iajs-2271	15	4	noted	note	VERB
iajs-2271	15	5	that	that	SCONJ
iajs-2271	15	6	archaea	archaea	PROPN
iajs-2271	15	7	have	have	VERB
iajs-2271	15	8	a	a	DET
iajs-2271	15	9	eubacterial	eubacterial	ADJ
iajs-2271	15	10	form	form	NOUN
iajs-2271	15	11	and	and	CCONJ
iajs-2271	15	12	a	a	DET
iajs-2271	15	13	ibn	ibn	PROPN
iajs-2271	15	14	al	al	PROPN
iajs-2271	15	15	haitham	haitham	PROPN
iajs-2271	15	16	journal	journal	PROPN
iajs-2271	15	17	for	for	ADP
iajs-2271	15	18	pure	pure	ADJ
iajs-2271	15	19	and	and	CCONJ
iajs-2271	15	20	applied	apply	VERB
iajs-2271	15	21	science	science	NOUN
iajs-2271	15	22	journal	journal	PROPN
iajs-2271	15	23	homepage	homepage	NOUN
iajs-2271	15	24	:	:	PUNCT
iajs-2271	15	25	http://jih.uobaghdad.edu.iq/index.php/j/index	http://jih.uobaghdad.edu.iq/index.php/j/index	PROPN
iajs-2271	15	26	.	.	PUNCT
iajs-2271	16	1	department	department	NOUN
iajs-2271	16	2	of	of	ADP
iajs-2271	16	3	natural	natural	ADJ
iajs-2271	16	4	resources	resource	NOUN
iajs-2271	16	5	,	,	PUNCT
iajs-2271	16	6	college	college	NOUN
iajs-2271	16	7	of	of	ADP
iajs-2271	16	8	agricultural	agricultural	ADJ
iajs-2271	16	9	sciences	sciences	PROPN
iajs-2271	16	10	engineering	engineering	NOUN
iajs-2271	16	11	,	,	PUNCT
iajs-2271	16	12	university	university	NOUN
iajs-2271	16	13	of	of	ADP
iajs-2271	16	14	sulaimani	sulaimani	PROPN
iajs-2271	16	15	,	,	PUNCT
iajs-2271	16	16	sulaimani	sulaimani	NOUN
iajs-2271	16	17	,	,	PUNCT
iajs-2271	16	18	kurdistan	kurdistan	PROPN
iajs-2271	16	19	-	-	PUNCT
iajs-2271	16	20	iraq	iraq	PROPN
iajs-2271	16	21	article	article	NOUN
iajs-2271	16	22	history	history	NOUN
iajs-2271	16	23	:	:	PUNCT
iajs-2271	16	24	received	receive	VERB
iajs-2271	16	25	10	10	NUM
iajs-2271	16	26	june	june	PROPN
iajs-2271	16	27	2019	2019	NUM
iajs-2271	16	28	,	,	PUNCT
iajs-2271	16	29	accepted	accept	VERB
iajs-2271	16	30	10	10	NUM
iajs-2271	16	31	july	july	PROPN
iajs-2271	16	32	2019	2019	NUM
iajs-2271	16	33	,	,	PUNCT
iajs-2271	16	34	publish	publish	VERB
iajs-2271	16	35	september	september	PROPN
iajs-2271	16	36	2019	2019	NUM
iajs-2271	16	37	.	.	PUNCT
iajs-2271	17	1	doi:10.30526/32.3.2271	doi:10.30526/32.3.2271	PROPN
iajs-2271	17	2	10.30526/32.3.2271https://mail.google.com	10.30526/32.3.2271https://mail.google.com	NUM
iajs-2271	17	3	/	/	SYM
iajs-2271	17	4	mail	mail	NOUN
iajs-2271	17	5	/	/	SYM
iajs-2271	17	6	u/0/#inbox	u/0/#inbox	NOUN
iajs-2271	17	7	/	/	SYM
iajs-2271	17	8	fmfcgxwdrhtwmlhmcvdh	fmfcgxwdrhtwmlhmcvdh	NOUN
iajs-2271	17	9	kgkbzbpbnvkq	kgkbzbpbnvkq	PROPN
iajs-2271	17	10	barzan.khayatt@univsul.edu.iq	barzan.khayatt@univsul.edu.iq	VERB
iajs-2271	17	11	automated	automate	VERB
iajs-2271	17	12	reconstruction	reconstruction	NOUN
iajs-2271	17	13	and	and	CCONJ
iajs-2271	17	14	manual	manual	ADJ
iajs-2271	17	15	curation	curation	NOUN
iajs-2271	17	16	of	of	ADP
iajs-2271	17	17	amino	amino	NOUN
iajs-2271	17	18	acid	acid	NOUN
iajs-2271	17	19	biosynthesis	biosynthesis	NOUN
iajs-2271	17	20	pathways	pathway	NOUN
iajs-2271	17	21	in	in	ADP
iajs-2271	17	22	sulfolobus	sulfolobus	ADJ
iajs-2271	17	23	solfataricus	solfataricus	ADJ
iajs-2271	17	24	p2	p2	PROPN
iajs-2271	17	25	https://figshare.com/s/8bea91e91cb6ce193fee	https://figshare.com/s/8bea91e91cb6ce193fee	NOUN
iajs-2271	17	26	mailto:barzan.khayatt@univsul.edu.iq	mailto:barzan.khayatt@univsul.edu.iq	PROPN
iajs-2271	17	27	mailto:barzan.khayatt@univsul.edu.iq	mailto:barzan.khayatt@univsul.edu.iq	PROPN
iajs-2271	17	28	2	2	NUM
iajs-2271	17	29	ibn	ibn	PROPN
iajs-2271	17	30	al	al	PROPN
iajs-2271	17	31	-	-	PUNCT
iajs-2271	17	32	haitham	haitham	PROPN
iajs-2271	17	33	jour	jour	X
iajs-2271	17	34	.	.	PROPN
iajs-2271	18	1	for	for	ADP
iajs-2271	18	2	pure	pure	ADJ
iajs-2271	18	3	&	&	CCONJ
iajs-2271	18	4	appl	appl	PROPN
iajs-2271	18	5	.	.	PUNCT
iajs-2271	19	1	sci	sci	PROPN
iajs-2271	19	2	.	.	PROPN
iajs-2271	19	3	32	32	NUM
iajs-2271	19	4	(	(	PUNCT
iajs-2271	19	5	3	3	NUM
iajs-2271	19	6	)	)	PUNCT
iajs-2271	19	7	2019	2019	NUM
iajs-2271	19	8	eukaryotic	eukaryotic	ADJ
iajs-2271	19	9	content	content	NOUN
iajs-2271	19	10	[	[	X
iajs-2271	19	11	1	1	NUM
iajs-2271	19	12	]	]	PUNCT
iajs-2271	19	13	.	.	PUNCT
iajs-2271	20	1	most	most	ADJ
iajs-2271	20	2	archaeal	archaeal	ADJ
iajs-2271	20	3	proteins	protein	NOUN
iajs-2271	20	4	participating	participate	VERB
iajs-2271	20	5	in	in	ADP
iajs-2271	20	6	dna	dna	PROPN
iajs-2271	20	7	replication	replication	NOUN
iajs-2271	20	8	are	be	AUX
iajs-2271	20	9	more	more	ADV
iajs-2271	20	10	similar	similar	ADJ
iajs-2271	20	11	in	in	ADP
iajs-2271	20	12	sequence	sequence	NOUN
iajs-2271	20	13	to	to	ADP
iajs-2271	20	14	those	those	PRON
iajs-2271	20	15	in	in	ADP
iajs-2271	20	16	eukarya	eukarya	NOUN
iajs-2271	20	17	than	than	ADP
iajs-2271	20	18	to	to	ADP
iajs-2271	20	19	analogous	analogous	ADJ
iajs-2271	20	20	replication	replication	NOUN
iajs-2271	20	21	proteins	protein	NOUN
iajs-2271	20	22	in	in	ADP
iajs-2271	20	23	bacteria	bacteria	NOUN
iajs-2271	20	24	[	[	X
iajs-2271	20	25	2	2	NUM
iajs-2271	20	26	]	]	PUNCT
iajs-2271	20	27	.	.	PUNCT
iajs-2271	21	1	the	the	DET
iajs-2271	21	2	absence	absence	NOUN
iajs-2271	21	3	of	of	ADP
iajs-2271	21	4	a	a	DET
iajs-2271	21	5	nucleus	nucleus	NOUN
iajs-2271	21	6	and	and	CCONJ
iajs-2271	21	7	the	the	DET
iajs-2271	21	8	genome	genome	NOUN
iajs-2271	21	9	organization	organization	NOUN
iajs-2271	21	10	especially	especially	ADV
iajs-2271	21	11	the	the	DET
iajs-2271	21	12	operonic	operonic	ADJ
iajs-2271	21	13	organization	organization	NOUN
iajs-2271	21	14	of	of	ADP
iajs-2271	21	15	many	many	ADJ
iajs-2271	21	16	genes	gene	NOUN
iajs-2271	21	17	in	in	ADP
iajs-2271	21	18	a	a	DET
iajs-2271	21	19	single	single	ADJ
iajs-2271	21	20	circular	circular	ADJ
iajs-2271	21	21	chromosome	chromosome	NOUN
iajs-2271	21	22	are	be	AUX
iajs-2271	21	23	the	the	DET
iajs-2271	21	24	important	important	ADJ
iajs-2271	21	25	common	common	ADJ
iajs-2271	21	26	features	feature	NOUN
iajs-2271	21	27	with	with	ADP
iajs-2271	21	28	bacteria	bacteria	NOUN
iajs-2271	21	29	.	.	PUNCT
iajs-2271	22	1	the	the	DET
iajs-2271	22	2	complete	complete	ADJ
iajs-2271	22	3	genome	genome	NOUN
iajs-2271	22	4	of	of	ADP
iajs-2271	22	5	sulfolobus	sulfolobus	ADJ
iajs-2271	22	6	solfataricus	solfataricus	ADJ
iajs-2271	22	7	p2	p2	NOUN
iajs-2271	22	8	was	be	AUX
iajs-2271	22	9	released	release	VERB
iajs-2271	22	10	in	in	ADP
iajs-2271	22	11	2001	2001	NUM
iajs-2271	22	12	with	with	ADP
iajs-2271	22	13	a	a	DET
iajs-2271	22	14	single	single	ADJ
iajs-2271	22	15	chromosome	chromosome	NOUN
iajs-2271	22	16	of	of	ADP
iajs-2271	22	17	2,992,245	2,992,245	NUM
iajs-2271	22	18	bp	bp	NOUN
iajs-2271	22	19	,	,	PUNCT
iajs-2271	22	20	holding	hold	VERB
iajs-2271	22	21	3032	3032	NUM
iajs-2271	22	22	identified	identify	VERB
iajs-2271	22	23	genes	gene	NOUN
iajs-2271	22	24	that	that	PRON
iajs-2271	22	25	code	code	VERB
iajs-2271	22	26	for	for	ADP
iajs-2271	22	27	2,997	2,997	NUM
iajs-2271	22	28	proteins	protein	NOUN
iajs-2271	22	29	[	[	X
iajs-2271	22	30	3	3	NUM
iajs-2271	22	31	]	]	PUNCT
iajs-2271	22	32	.	.	PUNCT
iajs-2271	23	1	(	(	PUNCT
iajs-2271	23	2	for	for	ADP
iajs-2271	23	3	updates	update	NOUN
iajs-2271	23	4	see	see	VERB
iajs-2271	23	5	ncbi	ncbi	PROPN
iajs-2271	23	6	refseq	refseq	PROPN
iajs-2271	23	7	:	:	PUNCT
iajs-2271	23	8	nc_002754.1	nc_002754.1	NUM
iajs-2271	23	9	)	)	PUNCT
iajs-2271	23	10	.	.	PUNCT
iajs-2271	24	1	approximately	approximately	ADV
iajs-2271	24	2	1/3	1/3	NUM
iajs-2271	24	3	of	of	ADP
iajs-2271	24	4	the	the	DET
iajs-2271	24	5	proteins	protein	NOUN
iajs-2271	24	6	has	have	VERB
iajs-2271	24	7	no	no	DET
iajs-2271	24	8	homologs	homolog	NOUN
iajs-2271	24	9	in	in	ADP
iajs-2271	24	10	other	other	ADJ
iajs-2271	24	11	sequenced	sequence	VERB
iajs-2271	24	12	genomes	genome	NOUN
iajs-2271	24	13	,	,	PUNCT
iajs-2271	24	14	40	40	NUM
iajs-2271	24	15	%	%	NOUN
iajs-2271	24	16	appear	appear	VERB
iajs-2271	24	17	to	to	PART
iajs-2271	24	18	be	be	AUX
iajs-2271	24	19	archaeal	archaeal	ADJ
iajs-2271	24	20	-	-	PUNCT
iajs-2271	24	21	specific	specific	ADJ
iajs-2271	24	22	and	and	CCONJ
iajs-2271	24	23	only	only	ADV
iajs-2271	24	24	12	12	NUM
iajs-2271	24	25	%	%	NOUN
iajs-2271	24	26	and	and	CCONJ
iajs-2271	24	27	2.3	2.3	NUM
iajs-2271	24	28	%	%	NOUN
iajs-2271	24	29	are	be	AUX
iajs-2271	24	30	shared	share	VERB
iajs-2271	24	31	exclusively	exclusively	ADV
iajs-2271	24	32	with	with	ADP
iajs-2271	24	33	bacteria	bacteria	NOUN
iajs-2271	24	34	and	and	CCONJ
iajs-2271	24	35	eukaryotes	eukaryote	NOUN
iajs-2271	24	36	,	,	PUNCT
iajs-2271	24	37	respectively	respectively	ADV
iajs-2271	24	38	(	(	PUNCT
iajs-2271	24	39	same	same	ADJ
iajs-2271	24	40	reference	reference	NOUN
iajs-2271	24	41	)	)	PUNCT
iajs-2271	24	42	.	.	PUNCT
iajs-2271	25	1	sulfolobus	sulfolobus	NOUN
iajs-2271	25	2	solfataricus	solfataricus	NOUN
iajs-2271	25	3	as	as	ADP
iajs-2271	25	4	an	an	DET
iajs-2271	25	5	important	important	ADJ
iajs-2271	25	6	model	model	NOUN
iajs-2271	25	7	organism	organism	NOUN
iajs-2271	25	8	belongs	belong	VERB
iajs-2271	25	9	to	to	ADP
iajs-2271	25	10	the	the	DET
iajs-2271	25	11	phylum	phylum	NOUN
iajs-2271	25	12	crenarchaeota	crenarchaeota	ADJ
iajs-2271	25	13	of	of	ADP
iajs-2271	25	14	the	the	DET
iajs-2271	25	15	life	life	NOUN
iajs-2271	25	16	domain	domain	NOUN
iajs-2271	25	17	archaea	archaea	NOUN
iajs-2271	25	18	.	.	PUNCT
iajs-2271	26	1	it	it	PRON
iajs-2271	26	2	inhabits	inhabit	VERB
iajs-2271	26	3	extreme	extreme	ADJ
iajs-2271	26	4	soil	soil	NOUN
iajs-2271	26	5	and	and	CCONJ
iajs-2271	26	6	water	water	NOUN
iajs-2271	26	7	environmental	environmental	ADJ
iajs-2271	26	8	niches	niche	NOUN
iajs-2271	26	9	with	with	ADP
iajs-2271	26	10	acidic	acidic	ADJ
iajs-2271	26	11	(	(	PUNCT
iajs-2271	26	12	ph	ph	NOUN
iajs-2271	26	13	2	2	NUM
iajs-2271	26	14	4	4	NUM
iajs-2271	26	15	)	)	PUNCT
iajs-2271	26	16	and	and	CCONJ
iajs-2271	26	17	high	high	ADJ
iajs-2271	26	18	temperature	temperature	NOUN
iajs-2271	26	19	conditions	condition	NOUN
iajs-2271	26	20	(	(	PUNCT
iajs-2271	26	21	around	around	ADV
iajs-2271	26	22	80	80	NUM
iajs-2271	26	23	o	o	NOUN
iajs-2271	26	24	c	c	NOUN
iajs-2271	26	25	)	)	PUNCT
iajs-2271	26	26	.	.	PUNCT
iajs-2271	27	1	sulfolobus	sulfolobus	NOUN
iajs-2271	27	2	solfataricus	solfataricus	NOUN
iajs-2271	27	3	as	as	ADP
iajs-2271	27	4	a	a	DET
iajs-2271	27	5	thermophilic	thermophilic	ADJ
iajs-2271	27	6	archaea	archaea	NOUN
iajs-2271	27	7	,	,	PUNCT
iajs-2271	27	8	its	its	PRON
iajs-2271	27	9	proteins	protein	NOUN
iajs-2271	27	10	remain	remain	VERB
iajs-2271	27	11	functional	functional	ADJ
iajs-2271	27	12	in	in	ADP
iajs-2271	27	13	high	high	ADJ
iajs-2271	27	14	temperatures	temperature	NOUN
iajs-2271	27	15	,	,	PUNCT
iajs-2271	27	16	which	which	PRON
iajs-2271	27	17	can	can	AUX
iajs-2271	27	18	be	be	AUX
iajs-2271	27	19	beneficial	beneficial	ADJ
iajs-2271	27	20	in	in	ADP
iajs-2271	27	21	food	food	NOUN
iajs-2271	27	22	,	,	PUNCT
iajs-2271	27	23	synthetic	synthetic	ADJ
iajs-2271	27	24	industry	industry	NOUN
iajs-2271	27	25	,	,	PUNCT
iajs-2271	27	26	biotechnology	biotechnology	NOUN
iajs-2271	27	27	,	,	PUNCT
iajs-2271	27	28	soil	soil	NOUN
iajs-2271	27	29	and	and	CCONJ
iajs-2271	27	30	water	water	NOUN
iajs-2271	27	31	environmental	environmental	ADJ
iajs-2271	27	32	researches.there	researches.there	PROPN
iajs-2271	27	33	is	be	AUX
iajs-2271	27	34	so	so	ADV
iajs-2271	27	35	far	far	ADV
iajs-2271	27	36	limited	limited	ADJ
iajs-2271	27	37	experimental	experimental	ADJ
iajs-2271	27	38	work	work	NOUN
iajs-2271	27	39	regarding	regard	VERB
iajs-2271	27	40	the	the	DET
iajs-2271	27	41	archaeal	archaeal	ADJ
iajs-2271	27	42	-	-	PUNCT
iajs-2271	27	43	specific	specific	ADJ
iajs-2271	27	44	metabolic	metabolic	NOUN
iajs-2271	27	45	pathways	pathway	NOUN
iajs-2271	27	46	and	and	CCONJ
iajs-2271	27	47	the	the	DET
iajs-2271	27	48	relating	relate	VERB
iajs-2271	27	49	genes	gene	NOUN
iajs-2271	27	50	characterization	characterization	NOUN
iajs-2271	27	51	.	.	PUNCT
iajs-2271	28	1	variant	variant	ADJ
iajs-2271	28	2	metabolic	metabolic	NOUN
iajs-2271	28	3	pathways	pathway	NOUN
iajs-2271	28	4	have	have	AUX
iajs-2271	28	5	evolved	evolve	VERB
iajs-2271	28	6	in	in	ADP
iajs-2271	28	7	archaea	archaea	NOUN
iajs-2271	28	8	,	,	PUNCT
iajs-2271	28	9	whereas	whereas	SCONJ
iajs-2271	28	10	the	the	DET
iajs-2271	28	11	central	central	ADJ
iajs-2271	28	12	metabolic	metabolic	NOUN
iajs-2271	28	13	fluxes	flux	NOUN
iajs-2271	28	14	of	of	ADP
iajs-2271	28	15	bacteria	bacteria	NOUN
iajs-2271	28	16	and	and	CCONJ
iajs-2271	28	17	eukaryotes	eukaryote	NOUN
iajs-2271	28	18	are	be	AUX
iajs-2271	28	19	generally	generally	ADV
iajs-2271	28	20	well	well	ADV
iajs-2271	28	21	conserved	conserved	ADJ
iajs-2271	29	1	[	[	X
iajs-2271	29	2	4	4	NUM
iajs-2271	29	3	]	]	PUNCT
iajs-2271	29	4	.	.	PUNCT
iajs-2271	30	1	automated	automate	VERB
iajs-2271	30	2	prediction	prediction	NOUN
iajs-2271	30	3	of	of	ADP
iajs-2271	30	4	metabolic	metabolic	NOUN
iajs-2271	30	5	pathways	pathway	NOUN
iajs-2271	30	6	via	via	ADP
iajs-2271	30	7	the	the	DET
iajs-2271	30	8	entire	entire	ADJ
iajs-2271	30	9	genome	genome	NOUN
iajs-2271	30	10	sequence	sequence	NOUN
iajs-2271	30	11	of	of	ADP
iajs-2271	30	12	an	an	DET
iajs-2271	30	13	organism	organism	NOUN
iajs-2271	30	14	is	be	AUX
iajs-2271	30	15	referred	refer	VERB
iajs-2271	30	16	to	to	ADP
iajs-2271	30	17	as	as	ADP
iajs-2271	30	18	metabolic	metabolic	NOUN
iajs-2271	30	19	reconstruction	reconstruction	NOUN
iajs-2271	30	20	[	[	X
iajs-2271	30	21	5	5	NUM
iajs-2271	30	22	]	]	PUNCT
iajs-2271	30	23	.	.	PUNCT
iajs-2271	31	1	reference	reference	NOUN
iajs-2271	31	2	knowledge	knowledge	NOUN
iajs-2271	31	3	bases	basis	NOUN
iajs-2271	31	4	(	(	PUNCT
iajs-2271	31	5	kbs	kbs	PROPN
iajs-2271	31	6	)	)	PUNCT
iajs-2271	31	7	,	,	PUNCT
iajs-2271	31	8	especially	especially	ADV
iajs-2271	31	9	metabolic	metabolic	ADJ
iajs-2271	31	10	pathway	pathway	NOUN
iajs-2271	31	11	-	-	PUNCT
iajs-2271	31	12	specific	specific	ADJ
iajs-2271	31	13	databases	database	NOUN
iajs-2271	31	14	such	such	ADJ
iajs-2271	31	15	as	as	ADP
iajs-2271	31	16	metacyc	metacyc	NOUN
iajs-2271	31	17	[	[	X
iajs-2271	31	18	6	6	NUM
iajs-2271	31	19	-	-	SYM
iajs-2271	31	20	9	9	NUM
iajs-2271	31	21	]	]	PUNCT
iajs-2271	31	22	.	.	PUNCT
iajs-2271	32	1	are	be	AUX
iajs-2271	32	2	efficiently	efficiently	ADV
iajs-2271	32	3	adopted	adopt	VERB
iajs-2271	32	4	in	in	ADP
iajs-2271	32	5	metabolic	metabolic	NOUN
iajs-2271	32	6	reconstructions	reconstruction	NOUN
iajs-2271	32	7	of	of	ADP
iajs-2271	32	8	target	target	NOUN
iajs-2271	32	9	organisms	organism	NOUN
iajs-2271	32	10	.	.	PUNCT
iajs-2271	33	1	pathway	pathway	NOUN
iajs-2271	33	2	/	/	SYM
iajs-2271	33	3	genome	genome	NOUN
iajs-2271	33	4	databases	database	NOUN
iajs-2271	33	5	(	(	PUNCT
iajs-2271	33	6	pgdbs	pgdbs	NOUN
iajs-2271	33	7	)	)	PUNCT
iajs-2271	33	8	specific	specific	NOUN
iajs-2271	33	9	for	for	ADP
iajs-2271	33	10	different	different	ADJ
iajs-2271	33	11	organisms	organism	NOUN
iajs-2271	33	12	are	be	AUX
iajs-2271	33	13	created	create	VERB
iajs-2271	33	14	through	through	ADP
iajs-2271	33	15	the	the	DET
iajs-2271	33	16	use	use	NOUN
iajs-2271	33	17	of	of	ADP
iajs-2271	33	18	“	"	PUNCT
iajs-2271	33	19	pathway	pathway	NOUN
iajs-2271	33	20	tools	tool	NOUN
iajs-2271	33	21	”	"	PUNCT
iajs-2271	33	22	software	software	NOUN
iajs-2271	33	23	[	[	X
iajs-2271	33	24	10,11	10,11	NOUN
iajs-2271	33	25	]	]	PUNCT
iajs-2271	33	26	.	.	PUNCT
iajs-2271	34	1	these	these	DET
iajs-2271	34	2	databases	database	NOUN
iajs-2271	34	3	are	be	AUX
iajs-2271	34	4	collections	collection	NOUN
iajs-2271	34	5	of	of	ADP
iajs-2271	34	6	the	the	DET
iajs-2271	34	7	annotated	annotate	VERB
iajs-2271	34	8	genome	genome	NOUN
iajs-2271	34	9	sequences	sequence	NOUN
iajs-2271	34	10	of	of	ADP
iajs-2271	34	11	the	the	DET
iajs-2271	34	12	target	target	NOUN
iajs-2271	34	13	organisms	organism	NOUN
iajs-2271	34	14	as	as	ADV
iajs-2271	34	15	well	well	ADV
iajs-2271	34	16	as	as	ADP
iajs-2271	34	17	their	their	PRON
iajs-2271	34	18	reconstructed	reconstructed	ADJ
iajs-2271	34	19	metabolic	metabolic	NOUN
iajs-2271	34	20	pathways	pathway	NOUN
iajs-2271	34	21	including	include	VERB
iajs-2271	34	22	information	information	NOUN
iajs-2271	34	23	on	on	ADP
iajs-2271	34	24	compounds	compound	NOUN
iajs-2271	34	25	,	,	PUNCT
iajs-2271	34	26	intermediates	intermediate	NOUN
iajs-2271	34	27	,	,	PUNCT
iajs-2271	34	28	cofactors	cofactor	NOUN
iajs-2271	34	29	,	,	PUNCT
iajs-2271	34	30	reactions	reaction	NOUN
iajs-2271	34	31	,	,	PUNCT
iajs-2271	34	32	genes	gene	NOUN
iajs-2271	34	33	and	and	CCONJ
iajs-2271	34	34	their	their	PRON
iajs-2271	34	35	products	product	NOUN
iajs-2271	34	36	.	.	PUNCT
iajs-2271	35	1	the	the	DET
iajs-2271	35	2	recent	recent	ADJ
iajs-2271	35	3	record	record	NOUN
iajs-2271	35	4	of	of	ADP
iajs-2271	35	5	the	the	DET
iajs-2271	35	6	pgdbs	pgdbs	NOUN
iajs-2271	35	7	that	that	PRON
iajs-2271	35	8	are	be	AUX
iajs-2271	35	9	now	now	ADV
iajs-2271	35	10	collected	collect	VERB
iajs-2271	35	11	in	in	ADP
iajs-2271	35	12	the	the	DET
iajs-2271	35	13	biocyc	biocyc	NOUN
iajs-2271	35	14	database	database	NOUN
iajs-2271	35	15	is	be	AUX
iajs-2271	35	16	14560	14560	NUM
iajs-2271	35	17	[	[	X
iajs-2271	35	18	12	12	NUM
iajs-2271	35	19	]	]	PUNCT
iajs-2271	35	20	.	.	PUNCT
iajs-2271	36	1	in	in	ADP
iajs-2271	36	2	general	general	ADJ
iajs-2271	36	3	,	,	PUNCT
iajs-2271	36	4	the	the	DET
iajs-2271	36	5	initial	initial	ADJ
iajs-2271	36	6	non	non	ADJ
iajs-2271	36	7	-	-	ADJ
iajs-2271	36	8	curated	curate	VERB
iajs-2271	36	9	pgdbs	pgdbs	NOUN
iajs-2271	36	10	lack	lack	VERB
iajs-2271	36	11	many	many	ADJ
iajs-2271	36	12	chemical	chemical	ADJ
iajs-2271	36	13	pathways	pathway	NOUN
iajs-2271	36	14	that	that	PRON
iajs-2271	36	15	are	be	AUX
iajs-2271	36	16	actually	actually	ADV
iajs-2271	36	17	present	present	ADJ
iajs-2271	36	18	in	in	ADP
iajs-2271	36	19	the	the	DET
iajs-2271	36	20	corresponding	corresponding	ADJ
iajs-2271	36	21	organism	organism	NOUN
iajs-2271	36	22	or	or	CCONJ
iajs-2271	36	23	conversely	conversely	ADV
iajs-2271	36	24	consist	consist	VERB
iajs-2271	36	25	of	of	ADP
iajs-2271	36	26	false	false	ADJ
iajs-2271	36	27	positives	positive	NOUN
iajs-2271	36	28	.	.	PUNCT
iajs-2271	37	1	the	the	DET
iajs-2271	37	2	addition	addition	NOUN
iajs-2271	37	3	of	of	ADP
iajs-2271	37	4	the	the	DET
iajs-2271	37	5	absent	absent	ADJ
iajs-2271	37	6	pathways	pathway	NOUN
iajs-2271	37	7	and	and	CCONJ
iajs-2271	37	8	removing	remove	VERB
iajs-2271	37	9	those	those	PRON
iajs-2271	37	10	that	that	PRON
iajs-2271	37	11	are	be	AUX
iajs-2271	37	12	really	really	ADV
iajs-2271	37	13	not	not	PART
iajs-2271	37	14	exist	exist	VERB
iajs-2271	37	15	in	in	ADP
iajs-2271	37	16	an	an	DET
iajs-2271	37	17	individual	individual	ADJ
iajs-2271	37	18	organism	organism	NOUN
iajs-2271	37	19	help	help	NOUN
iajs-2271	37	20	in	in	ADP
iajs-2271	37	21	the	the	DET
iajs-2271	37	22	quality	quality	NOUN
iajs-2271	37	23	improvement	improvement	NOUN
iajs-2271	37	24	of	of	ADP
iajs-2271	37	25	the	the	DET
iajs-2271	37	26	genome	genome	NOUN
iajs-2271	37	27	annotation	annotation	NOUN
iajs-2271	37	28	.	.	PUNCT
iajs-2271	38	1	if	if	SCONJ
iajs-2271	38	2	the	the	DET
iajs-2271	38	3	corresponding	corresponding	ADJ
iajs-2271	38	4	genes	gene	NOUN
iajs-2271	38	5	encoding	encode	VERB
iajs-2271	38	6	the	the	DET
iajs-2271	38	7	majority	majority	NOUN
iajs-2271	38	8	enzymes	enzyme	NOUN
iajs-2271	38	9	in	in	ADP
iajs-2271	38	10	a	a	DET
iajs-2271	38	11	metabolic	metabolic	NOUN
iajs-2271	38	12	pathway	pathway	NOUN
iajs-2271	38	13	have	have	AUX
iajs-2271	38	14	been	be	AUX
iajs-2271	38	15	identified	identify	VERB
iajs-2271	38	16	in	in	ADP
iajs-2271	38	17	the	the	DET
iajs-2271	38	18	annotated	annotate	VERB
iajs-2271	38	19	genome	genome	NOUN
iajs-2271	38	20	,	,	PUNCT
iajs-2271	38	21	the	the	DET
iajs-2271	38	22	missing	miss	VERB
iajs-2271	38	23	steps	step	NOUN
iajs-2271	38	24	are	be	AUX
iajs-2271	38	25	likely	likely	ADJ
iajs-2271	38	26	to	to	PART
iajs-2271	38	27	be	be	AUX
iajs-2271	38	28	present	present	ADJ
iajs-2271	38	29	amongst	amongst	ADP
iajs-2271	38	30	the	the	DET
iajs-2271	38	31	unidentified	unidentified	ADJ
iajs-2271	38	32	genes	gene	NOUN
iajs-2271	38	33	and	and	CCONJ
iajs-2271	38	34	are	be	AUX
iajs-2271	38	35	worth	worth	ADJ
iajs-2271	38	36	to	to	PART
iajs-2271	38	37	be	be	AUX
iajs-2271	38	38	identified	identify	VERB
iajs-2271	38	39	and	and	CCONJ
iajs-2271	38	40	assigned	assign	VERB
iajs-2271	38	41	.	.	PUNCT
iajs-2271	39	1	if	if	SCONJ
iajs-2271	39	2	a	a	DET
iajs-2271	39	3	protein	protein	NOUN
iajs-2271	39	4	has	have	AUX
iajs-2271	39	5	not	not	PART
iajs-2271	39	6	been	be	AUX
iajs-2271	39	7	assigned	assign	VERB
iajs-2271	39	8	a	a	DET
iajs-2271	39	9	specific	specific	ADJ
iajs-2271	39	10	function	function	NOUN
iajs-2271	39	11	during	during	ADP
iajs-2271	39	12	the	the	DET
iajs-2271	39	13	annotation	annotation	NOUN
iajs-2271	39	14	process	process	NOUN
iajs-2271	39	15	(	(	PUNCT
iajs-2271	39	16	annotations	annotation	NOUN
iajs-2271	39	17	fail	fail	VERB
iajs-2271	39	18	to	to	PART
iajs-2271	39	19	assign	assign	VERB
iajs-2271	39	20	function	function	NOUN
iajs-2271	39	21	to	to	ADP
iajs-2271	39	22	40	40	NUM
iajs-2271	39	23	–	–	PUNCT
iajs-2271	39	24	60	60	NUM
iajs-2271	39	25	%	%	NOUN
iajs-2271	39	26	of	of	ADP
iajs-2271	39	27	the	the	DET
iajs-2271	39	28	newly	newly	ADV
iajs-2271	39	29	sequenced	sequence	VERB
iajs-2271	39	30	proteins	protein	NOUN
iajs-2271	39	31	)	)	PUNCT
iajs-2271	39	32	,	,	PUNCT
iajs-2271	39	33	any	any	DET
iajs-2271	39	34	reaction	reaction	NOUN
iajs-2271	39	35	catalyzed	catalyze	VERB
iajs-2271	39	36	by	by	ADP
iajs-2271	39	37	that	that	DET
iajs-2271	39	38	protein	protein	NOUN
iajs-2271	39	39	would	would	AUX
iajs-2271	39	40	appear	appear	VERB
iajs-2271	39	41	as	as	ADP
iajs-2271	39	42	a	a	DET
iajs-2271	39	43	missing	miss	VERB
iajs-2271	39	44	enzyme	enzyme	NOUN
iajs-2271	39	45	(	(	PUNCT
iajs-2271	39	46	pathway	pathway	NOUN
iajs-2271	39	47	hole	hole	NOUN
iajs-2271	39	48	)	)	PUNCT
iajs-2271	39	49	in	in	ADP
iajs-2271	39	50	a	a	DET
iajs-2271	39	51	pgdb	pgdb	NOUN
iajs-2271	39	52	[	[	X
iajs-2271	39	53	13	13	NUM
iajs-2271	39	54	]	]	PUNCT
iajs-2271	39	55	.	.	PUNCT
iajs-2271	40	1	few	few	ADJ
iajs-2271	40	2	available	available	ADJ
iajs-2271	40	3	research	research	NOUN
iajs-2271	40	4	works	work	NOUN
iajs-2271	40	5	regarding	regard	VERB
iajs-2271	40	6	metabolic	metabolic	NOUN
iajs-2271	40	7	reconstructions	reconstruction	NOUN
iajs-2271	40	8	for	for	ADP
iajs-2271	40	9	the	the	DET
iajs-2271	40	10	model	model	NOUN
iajs-2271	40	11	thermoacidophilic	thermoacidophilic	NOUN
iajs-2271	40	12	archaeon	archaeon	PROPN
iajs-2271	40	13	sulfolobus	sulfolobus	NOUN
iajs-2271	40	14	solfataricus	solfataricus	NOUN
iajs-2271	40	15	,	,	PUNCT
iajs-2271	40	16	focus	focus	VERB
iajs-2271	40	17	on	on	ADP
iajs-2271	40	18	the	the	DET
iajs-2271	40	19	metabolic	metabolic	NOUN
iajs-2271	40	20	networks	network	NOUN
iajs-2271	40	21	response	response	NOUN
iajs-2271	40	22	to	to	ADP
iajs-2271	40	23	different	different	ADJ
iajs-2271	40	24	carbon	carbon	NOUN
iajs-2271	40	25	sources	source	NOUN
iajs-2271	40	26	and	and	CCONJ
iajs-2271	40	27	central	central	ADJ
iajs-2271	40	28	carbohydrate	carbohydrate	ADJ
iajs-2271	40	29	metabolism	metabolism	NOUN
iajs-2271	40	30	[	[	X
iajs-2271	40	31	14	14	NUM
iajs-2271	40	32	-	-	SYM
iajs-2271	40	33	16	16	NUM
iajs-2271	40	34	]	]	PUNCT
iajs-2271	40	35	.	.	PUNCT
iajs-2271	41	1	the	the	DET
iajs-2271	41	2	majority	majority	NOUN
iajs-2271	41	3	of	of	ADP
iajs-2271	41	4	the	the	DET
iajs-2271	41	5	genes	gene	NOUN
iajs-2271	41	6	that	that	PRON
iajs-2271	41	7	are	be	AUX
iajs-2271	41	8	known	know	VERB
iajs-2271	41	9	to	to	PART
iajs-2271	41	10	be	be	AUX
iajs-2271	41	11	involved	involve	VERB
iajs-2271	41	12	in	in	ADP
iajs-2271	41	13	different	different	ADJ
iajs-2271	41	14	amino	amino	NOUN
iajs-2271	41	15	acid	acid	NOUN
iajs-2271	41	16	biosynthetic	biosynthetic	ADJ
iajs-2271	41	17	pathways	pathway	NOUN
iajs-2271	41	18	were	be	AUX
iajs-2271	41	19	detected	detect	VERB
iajs-2271	41	20	in	in	ADP
iajs-2271	41	21	sulfolobus	sulfolobus	NOUN
iajs-2271	41	22	solfataricus	solfataricus	ADJ
iajs-2271	41	23	p2	p2	NOUN
iajs-2271	41	24	genome	genome	NOUN
iajs-2271	41	25	(	(	PUNCT
iajs-2271	41	26	http://www-archbac.upsud.fr/projects/sulfolobus/amino_acids_biosynth.html	http://www-archbac.upsud.fr/projects/sulfolobus/amino_acids_biosynth.html	NOUN
iajs-2271	41	27	)	)	PUNCT
iajs-2271	41	28	.	.	PUNCT
iajs-2271	42	1	depending	depend	VERB
iajs-2271	42	2	on	on	ADP
iajs-2271	42	3	these	these	DET
iajs-2271	42	4	detected	detect	VERB
iajs-2271	42	5	genes	gene	NOUN
iajs-2271	42	6	,	,	PUNCT
iajs-2271	42	7	one	one	PRON
iajs-2271	42	8	can	can	AUX
iajs-2271	42	9	not	not	PART
iajs-2271	42	10	assume	assume	VERB
iajs-2271	42	11	that	that	SCONJ
iajs-2271	42	12	sulfolobus	sulfolobus	NOUN
iajs-2271	42	13	solfataricus	solfataricus	NOUN
iajs-2271	42	14	is	be	AUX
iajs-2271	42	15	able	able	ADJ
iajs-2271	42	16	to	to	PART
iajs-2271	42	17	synthesize	synthesize	VERB
iajs-2271	42	18	all	all	DET
iajs-2271	42	19	amino	amino	ADJ
iajs-2271	42	20	acids	acid	NOUN
iajs-2271	42	21	,	,	PUNCT
iajs-2271	42	22	despite	despite	SCONJ
iajs-2271	42	23	the	the	DET
iajs-2271	42	24	signals	signal	NOUN
iajs-2271	42	25	of	of	ADP
iajs-2271	42	26	that	that	DET
iajs-2271	42	27	ability	ability	NOUN
iajs-2271	42	28	(	(	PUNCT
iajs-2271	42	29	see	see	VERB
iajs-2271	42	30	[	[	X
iajs-2271	42	31	17	17	NUM
iajs-2271	42	32	]	]	NUM
iajs-2271	42	33	)	)	PUNCT
iajs-2271	42	34	.	.	PUNCT
iajs-2271	43	1	there	there	PRON
iajs-2271	43	2	are	be	VERB
iajs-2271	43	3	very	very	ADV
iajs-2271	43	4	limited	limited	ADJ
iajs-2271	43	5	lab	lab	NOUN
iajs-2271	43	6	results	result	NOUN
iajs-2271	43	7	so	so	ADV
iajs-2271	43	8	far	far	ADV
iajs-2271	43	9	to	to	PART
iajs-2271	43	10	get	get	VERB
iajs-2271	43	11	complete	complete	ADJ
iajs-2271	43	12	http://www-archbac.u-psud.fr/projects/sulfolobus/amino_acids_biosynth.html	http://www-archbac.u-psud.fr/projects/sulfolobus/amino_acids_biosynth.html	PROPN
iajs-2271	43	13	http://www-archbac.u-psud.fr/projects/sulfolobus/amino_acids_biosynth.html	http://www-archbac.u-psud.fr/projects/sulfolobus/amino_acids_biosynth.html	PROPN
iajs-2271	43	14	3	3	NUM
iajs-2271	43	15	ibn	ibn	PROPN
iajs-2271	43	16	al	al	PROPN
iajs-2271	43	17	-	-	PUNCT
iajs-2271	43	18	haitham	haitham	PROPN
iajs-2271	43	19	jour	jour	X
iajs-2271	43	20	.	.	PROPN
iajs-2271	44	1	for	for	ADP
iajs-2271	44	2	pure	pure	ADJ
iajs-2271	44	3	&	&	CCONJ
iajs-2271	44	4	appl	appl	PROPN
iajs-2271	44	5	.	.	PUNCT
iajs-2271	45	1	sci	sci	PROPN
iajs-2271	45	2	.	.	PROPN
iajs-2271	45	3	32	32	NUM
iajs-2271	45	4	(	(	PUNCT
iajs-2271	45	5	3	3	NUM
iajs-2271	45	6	)	)	PUNCT
iajs-2271	45	7	2019	2019	NUM
iajs-2271	45	8	insight	insight	NOUN
iajs-2271	45	9	into	into	ADP
iajs-2271	45	10	the	the	DET
iajs-2271	45	11	amino	amino	NOUN
iajs-2271	45	12	acids	acid	NOUN
iajs-2271	45	13	biosynthesis	biosynthesis	NOUN
iajs-2271	45	14	in	in	ADP
iajs-2271	45	15	sulfolobus	sulfolobus	ADJ
iajs-2271	45	16	solfataricus	solfataricus	NOUN
iajs-2271	45	17	.	.	PUNCT
iajs-2271	46	1	they	they	PRON
iajs-2271	46	2	do	do	AUX
iajs-2271	46	3	not	not	PART
iajs-2271	46	4	exceed	exceed	VERB
iajs-2271	46	5	identification	identification	NOUN
iajs-2271	46	6	and	and	CCONJ
iajs-2271	46	7	characterization	characterization	NOUN
iajs-2271	46	8	of	of	ADP
iajs-2271	46	9	some	some	DET
iajs-2271	46	10	individual	individual	ADJ
iajs-2271	46	11	enzymes	enzyme	NOUN
iajs-2271	46	12	catalyzing	catalyzing	NOUN
iajs-2271	46	13	reactions	reaction	NOUN
iajs-2271	46	14	in	in	ADP
iajs-2271	46	15	some	some	DET
iajs-2271	46	16	amino	amino	NOUN
iajs-2271	46	17	acid	acid	NOUN
iajs-2271	46	18	biosynthetic	biosynthetic	ADJ
iajs-2271	46	19	pathways	pathway	NOUN
iajs-2271	46	20	.	.	PUNCT
iajs-2271	47	1	there	there	PRON
iajs-2271	47	2	is	be	VERB
iajs-2271	47	3	diversity	diversity	NOUN
iajs-2271	47	4	in	in	ADP
iajs-2271	47	5	amino	amino	NOUN
iajs-2271	47	6	acid	acid	NOUN
iajs-2271	47	7	biosynthetic	biosynthetic	ADJ
iajs-2271	47	8	pathways	pathway	NOUN
iajs-2271	47	9	even	even	ADV
iajs-2271	47	10	among	among	ADP
iajs-2271	47	11	the	the	DET
iajs-2271	47	12	archaeal	archaeal	ADJ
iajs-2271	47	13	species	specie	NOUN
iajs-2271	47	14	.	.	PUNCT
iajs-2271	48	1	for	for	ADP
iajs-2271	48	2	example	example	NOUN
iajs-2271	48	3	the	the	DET
iajs-2271	48	4	cysteine	cysteine	NOUN
iajs-2271	48	5	biosynthesis	biosynthesis	NOUN
iajs-2271	48	6	pathway	pathway	NOUN
iajs-2271	48	7	in	in	ADP
iajs-2271	48	8	methanosarcina	methanosarcina	PROPN
iajs-2271	48	9	barkeri	barkeri	PROPN
iajs-2271	48	10	is	be	AUX
iajs-2271	48	11	achieved	achieve	VERB
iajs-2271	48	12	by	by	ADP
iajs-2271	48	13	a	a	DET
iajs-2271	48	14	bacteria	bacteria	NOUN
iajs-2271	48	15	-	-	PUNCT
iajs-2271	48	16	like	like	ADJ
iajs-2271	48	17	cysk	cysk	ADJ
iajs-2271	48	18	gene	gene	NOUN
iajs-2271	48	19	encoding	encode	VERB
iajs-2271	48	20	oacetylserine(thiol)-lyase	oacetylserine(thiol)-lyase	NOUN
iajs-2271	48	21	-	-	PUNCT
iajs-2271	48	22	a	a	NOUN
iajs-2271	48	23	and	and	CCONJ
iajs-2271	48	24	an	an	DET
iajs-2271	48	25	adjacent	adjacent	ADJ
iajs-2271	48	26	to	to	PART
iajs-2271	48	27	cysk	cysk	VERB
iajs-2271	48	28	gene	gene	NOUN
iajs-2271	48	29	known	know	VERB
iajs-2271	48	30	as	as	ADP
iajs-2271	48	31	cyse	cyse	NOUN
iajs-2271	48	32	gene	gene	NOUN
iajs-2271	48	33	(	(	PUNCT
iajs-2271	48	34	serine	serine	NOUN
iajs-2271	48	35	transacetylase	transacetylase	NOUN
iajs-2271	48	36	)	)	PUNCT
iajs-2271	49	1	[	[	X
iajs-2271	49	2	18	18	NUM
iajs-2271	49	3	]	]	PUNCT
iajs-2271	49	4	.	.	PUNCT
iajs-2271	50	1	another	another	DET
iajs-2271	50	2	bacteria	bacteria	NOUN
iajs-2271	50	3	-	-	PUNCT
iajs-2271	50	4	like	like	ADJ
iajs-2271	50	5	cysm	cysm	NOUN
iajs-2271	50	6	gene	gene	NOUN
iajs-2271	50	7	encoding	encode	VERB
iajs-2271	50	8	o	o	PROPN
iajs-2271	50	9	-	-	ADJ
iajs-2271	50	10	acetylserine(thiol)-lyase	acetylserine(thiol)-lyase	ADJ
iajs-2271	50	11	-	-	PUNCT
iajs-2271	50	12	b	b	NOUN
iajs-2271	50	13	is	be	AUX
iajs-2271	50	14	detected	detect	VERB
iajs-2271	50	15	in	in	ADP
iajs-2271	50	16	sulfolobus	sulfolobus	NOUN
iajs-2271	50	17	solfataricus	solfataricus	NOUN
iajs-2271	50	18	[	[	X
iajs-2271	50	19	3	3	NUM
iajs-2271	50	20	]	]	PUNCT
iajs-2271	50	21	.	.	PUNCT
iajs-2271	51	1	whereas	whereas	SCONJ
iajs-2271	51	2	no	no	DET
iajs-2271	51	3	orthologs	ortholog	NOUN
iajs-2271	51	4	for	for	ADP
iajs-2271	51	5	this	this	DET
iajs-2271	51	6	gene	gene	NOUN
iajs-2271	51	7	can	can	AUX
iajs-2271	51	8	be	be	AUX
iajs-2271	51	9	detected	detect	VERB
iajs-2271	51	10	in	in	ADP
iajs-2271	51	11	methanocaldococcus	methanocaldococcus	NOUN
iajs-2271	51	12	jannaschii	jannaschii	PROPN
iajs-2271	51	13	,	,	PUNCT
iajs-2271	51	14	methanobacterium	methanobacterium	NOUN
iajs-2271	51	15	thermoautotrophicum	thermoautotrophicum	NOUN
iajs-2271	51	16	and	and	CCONJ
iajs-2271	51	17	archaeoglobus	archaeoglobus	PROPN
iajs-2271	51	18	fulgidus	fulgidus	PROPN
iajs-2271	51	19	.	.	PUNCT
iajs-2271	52	1	this	this	PRON
iajs-2271	52	2	can	can	AUX
iajs-2271	52	3	be	be	AUX
iajs-2271	52	4	interpreted	interpret	VERB
iajs-2271	52	5	by	by	ADP
iajs-2271	52	6	the	the	DET
iajs-2271	52	7	existence	existence	NOUN
iajs-2271	52	8	of	of	ADP
iajs-2271	52	9	unrecognizable	unrecognizable	ADJ
iajs-2271	52	10	genes	gene	NOUN
iajs-2271	52	11	catalyzing	catalyze	VERB
iajs-2271	52	12	the	the	DET
iajs-2271	52	13	same	same	ADJ
iajs-2271	52	14	function	function	NOUN
iajs-2271	52	15	(	(	PUNCT
iajs-2271	52	16	non	non	ADJ
iajs-2271	52	17	-	-	ADJ
iajs-2271	52	18	orthologous	orthologous	ADJ
iajs-2271	52	19	gene	gene	NOUN
iajs-2271	52	20	displacement	displacement	NOUN
iajs-2271	52	21	)	)	PUNCT
iajs-2271	52	22	or	or	CCONJ
iajs-2271	52	23	a	a	DET
iajs-2271	52	24	different	different	ADJ
iajs-2271	52	25	cysteine	cysteine	NOUN
iajs-2271	52	26	biosynthesis	biosynthesis	NOUN
iajs-2271	52	27	pathway	pathway	NOUN
iajs-2271	52	28	.	.	PUNCT
iajs-2271	53	1	the	the	DET
iajs-2271	53	2	genes	gene	NOUN
iajs-2271	53	3	encoding	encode	VERB
iajs-2271	53	4	histidine	histidine	NOUN
iajs-2271	53	5	biosynthesis	biosynthesis	NOUN
iajs-2271	53	6	pathway	pathway	NOUN
iajs-2271	53	7	,	,	PUNCT
iajs-2271	53	8	were	be	AUX
iajs-2271	53	9	detected	detect	VERB
iajs-2271	53	10	in	in	ADP
iajs-2271	53	11	sulfolobus	sulfolobus	NOUN
iajs-2271	53	12	solfataricus	solfataricus	ADJ
iajs-2271	53	13	genome	genome	NOUN
iajs-2271	53	14	(	(	PUNCT
iajs-2271	53	15	sso0592	sso0592	NOUN
iajs-2271	53	16	–	–	PUNCT
iajs-2271	53	17	0600	0600	NUM
iajs-2271	53	18	and	and	CCONJ
iajs-2271	53	19	sso6227	sso6227	ADJ
iajs-2271	53	20	)	)	PUNCT
iajs-2271	53	21	,	,	PUNCT
iajs-2271	53	22	they	they	PRON
iajs-2271	53	23	show	show	VERB
iajs-2271	53	24	a	a	DET
iajs-2271	53	25	novel	novel	ADJ
iajs-2271	53	26	organization	organization	NOUN
iajs-2271	53	27	in	in	ADP
iajs-2271	53	28	histidine	histidine	ADJ
iajs-2271	53	29	operon	operon	NOUN
iajs-2271	53	30	,	,	PUNCT
iajs-2271	53	31	hiscgabdfdehi	hiscgabdfdehi	NOUN
iajs-2271	54	1	[	[	X
iajs-2271	54	2	3	3	NUM
iajs-2271	54	3	]	]	PUNCT
iajs-2271	54	4	.	.	PUNCT
iajs-2271	55	1	in	in	ADP
iajs-2271	55	2	the	the	DET
iajs-2271	55	3	enterobacteria	enterobacteria	NOUN
iajs-2271	55	4	,	,	PUNCT
iajs-2271	55	5	the	the	DET
iajs-2271	55	6	two	two	NUM
iajs-2271	55	7	reactions	reaction	NOUN
iajs-2271	55	8	are	be	AUX
iajs-2271	55	9	associated	associate	VERB
iajs-2271	55	10	with	with	ADP
iajs-2271	55	11	a	a	DET
iajs-2271	55	12	single	single	ADJ
iajs-2271	55	13	bifunctional	bifunctional	ADJ
iajs-2271	55	14	polypeptide	polypeptide	NOUN
iajs-2271	55	15	encoded	encode	VERB
iajs-2271	55	16	by	by	ADP
iajs-2271	55	17	hisb	hisb	NOUN
iajs-2271	55	18	,	,	PUNCT
iajs-2271	55	19	whereas	whereas	SCONJ
iajs-2271	55	20	the	the	DET
iajs-2271	55	21	two	two	NUM
iajs-2271	55	22	reactions	reaction	NOUN
iajs-2271	55	23	in	in	ADP
iajs-2271	55	24	archaea	archaea	NOUN
iajs-2271	55	25	are	be	AUX
iajs-2271	55	26	encoded	encode	VERB
iajs-2271	55	27	by	by	ADP
iajs-2271	55	28	two	two	NUM
iajs-2271	55	29	separate	separate	ADJ
iajs-2271	55	30	genes	gene	NOUN
iajs-2271	55	31	[	[	X
iajs-2271	55	32	19	19	NUM
iajs-2271	55	33	]	]	PUNCT
iajs-2271	55	34	.	.	PUNCT
iajs-2271	56	1	the	the	DET
iajs-2271	56	2	automated	automate	VERB
iajs-2271	56	3	reconstruction	reconstruction	NOUN
iajs-2271	56	4	of	of	ADP
iajs-2271	56	5	the	the	DET
iajs-2271	56	6	metabolic	metabolic	NOUN
iajs-2271	56	7	pathways	pathway	NOUN
iajs-2271	56	8	regarding	regard	VERB
iajs-2271	56	9	amino	amino	ADJ
iajs-2271	56	10	acids	acid	NOUN
iajs-2271	56	11	biosynthesis	biosynthesis	NOUN
iajs-2271	56	12	in	in	ADP
iajs-2271	56	13	sulfolobus	sulfolobus	ADJ
iajs-2271	56	14	solfataricus	solfataricus	ADJ
iajs-2271	56	15	p2	p2	PROPN
iajs-2271	56	16	showed	show	VERB
iajs-2271	56	17	many	many	ADJ
iajs-2271	56	18	enzymatic	enzymatic	ADJ
iajs-2271	56	19	gaps	gap	NOUN
iajs-2271	56	20	(	(	PUNCT
iajs-2271	56	21	pathway	pathway	NOUN
iajs-2271	56	22	holes	hole	NOUN
iajs-2271	56	23	)	)	PUNCT
iajs-2271	56	24	.	.	PUNCT
iajs-2271	57	1	the	the	DET
iajs-2271	57	2	current	current	ADJ
iajs-2271	57	3	research	research	NOUN
iajs-2271	57	4	intends	intend	VERB
iajs-2271	57	5	filling	fill	VERB
iajs-2271	57	6	in	in	ADP
iajs-2271	57	7	these	these	DET
iajs-2271	57	8	gaps	gap	NOUN
iajs-2271	57	9	by	by	ADP
iajs-2271	57	10	the	the	DET
iajs-2271	57	11	discovery	discovery	NOUN
iajs-2271	57	12	of	of	ADP
iajs-2271	57	13	the	the	DET
iajs-2271	57	14	genes	gene	NOUN
iajs-2271	57	15	and	and	CCONJ
iajs-2271	57	16	the	the	DET
iajs-2271	57	17	enzymes	enzyme	NOUN
iajs-2271	57	18	they	they	PRON
iajs-2271	57	19	code	code	VERB
iajs-2271	57	20	for	for	ADP
iajs-2271	57	21	the	the	DET
iajs-2271	57	22	enzymatic	enzymatic	ADJ
iajs-2271	57	23	reactions	reaction	NOUN
iajs-2271	57	24	in	in	ADP
iajs-2271	57	25	the	the	DET
iajs-2271	57	26	amino	amino	NOUN
iajs-2271	57	27	acid	acid	NOUN
iajs-2271	57	28	synthetic	synthetic	NOUN
iajs-2271	57	29	pathways	pathway	NOUN
iajs-2271	57	30	in	in	ADP
iajs-2271	57	31	sulfolobus	sulfolobus	NOUN
iajs-2271	57	32	solfataricus	solfataricus	ADJ
iajs-2271	57	33	p2	p2	NOUN
iajs-2271	57	34	strain	strain	NOUN
iajs-2271	57	35	.	.	PUNCT
iajs-2271	58	1	2	2	X
iajs-2271	58	2	.	.	X
iajs-2271	58	3	materials	material	NOUN
iajs-2271	58	4	and	and	CCONJ
iajs-2271	58	5	methods	method	NOUN
iajs-2271	58	6	2.1	2.1	NUM
iajs-2271	58	7	.	.	PUNCT
iajs-2271	58	8	sulfolobus	sulfolobus	NOUN
iajs-2271	58	9	solfataricus	solfataricus	ADJ
iajs-2271	58	10	pgdb	pgdb	PROPN
iajs-2271	58	11	creation	creation	NOUN
iajs-2271	58	12	the	the	DET
iajs-2271	58	13	“	"	PUNCT
iajs-2271	58	14	pathway	pathway	NOUN
iajs-2271	58	15	tools	tool	NOUN
iajs-2271	58	16	”	"	PUNCT
iajs-2271	58	17	software	software	NOUN
iajs-2271	58	18	[	[	X
iajs-2271	58	19	10	10	NUM
iajs-2271	58	20	]	]	PUNCT
iajs-2271	58	21	.	.	PUNCT
iajs-2271	59	1	was	be	AUX
iajs-2271	59	2	used	use	VERB
iajs-2271	59	3	to	to	PART
iajs-2271	59	4	create	create	VERB
iajs-2271	59	5	a	a	DET
iajs-2271	59	6	pathway	pathway	NOUN
iajs-2271	59	7	/	/	SYM
iajs-2271	59	8	genome	genome	NOUN
iajs-2271	59	9	database	database	NOUN
iajs-2271	59	10	specific	specific	ADJ
iajs-2271	59	11	for	for	ADP
iajs-2271	59	12	sulfolobus	sulfolobus	NOUN
iajs-2271	59	13	solfataricus	solfataricus	ADJ
iajs-2271	59	14	p2	p2	NOUN
iajs-2271	59	15	,	,	PUNCT
iajs-2271	59	16	and	and	CCONJ
iajs-2271	59	17	was	be	AUX
iajs-2271	59	18	saved	save	VERB
iajs-2271	59	19	in	in	ADP
iajs-2271	59	20	a	a	DET
iajs-2271	59	21	local	local	ADJ
iajs-2271	59	22	server	server	NOUN
iajs-2271	59	23	(	(	PUNCT
iajs-2271	59	24	a	a	DET
iajs-2271	59	25	non	non	ADJ
iajs-2271	59	26	-	-	ADJ
iajs-2271	59	27	curated	curate	VERB
iajs-2271	59	28	version	version	NOUN
iajs-2271	59	29	is	be	AUX
iajs-2271	59	30	available	available	ADJ
iajs-2271	59	31	at	at	ADP
iajs-2271	59	32	biocyc	biocyc	NOUN
iajs-2271	59	33	(	(	PUNCT
iajs-2271	59	34	https://biocyc.org/organism-summary?object=ssol273057	https://biocyc.org/organism-summary?object=ssol273057	NOUN
iajs-2271	59	35	)	)	PUNCT
iajs-2271	59	36	.	.	PUNCT
iajs-2271	60	1	the	the	DET
iajs-2271	60	2	initial	initial	ADJ
iajs-2271	60	3	metabolic	metabolic	NOUN
iajs-2271	60	4	pathways	pathway	NOUN
iajs-2271	60	5	were	be	AUX
iajs-2271	60	6	predicted	predict	VERB
iajs-2271	60	7	for	for	ADP
iajs-2271	60	8	the	the	DET
iajs-2271	60	9	target	target	NOUN
iajs-2271	60	10	organism	organism	NOUN
iajs-2271	60	11	via	via	ADP
iajs-2271	60	12	the	the	DET
iajs-2271	60	13	use	use	NOUN
iajs-2271	60	14	of	of	ADP
iajs-2271	60	15	its	its	PRON
iajs-2271	60	16	genome	genome	NOUN
iajs-2271	60	17	annotation	annotation	NOUN
iajs-2271	60	18	file	file	NOUN
iajs-2271	60	19	and	and	CCONJ
iajs-2271	60	20	the	the	DET
iajs-2271	60	21	entire	entire	ADJ
iajs-2271	60	22	genome	genome	NOUN
iajs-2271	60	23	sequence	sequence	NOUN
iajs-2271	60	24	file	file	NOUN
iajs-2271	60	25	(	(	PUNCT
iajs-2271	60	26	ncbi	ncbi	PROPN
iajs-2271	60	27	reference	reference	NOUN
iajs-2271	60	28	sequence	sequence	NOUN
iajs-2271	60	29	:	:	PUNCT
iajs-2271	60	30	nc_002754.1	nc_002754.1	NUM
iajs-2271	60	31	)	)	PUNCT
iajs-2271	60	32	as	as	ADP
iajs-2271	60	33	input	input	NOUN
iajs-2271	60	34	files	file	NOUN
iajs-2271	60	35	for	for	ADP
iajs-2271	60	36	the	the	DET
iajs-2271	60	37	“	"	PUNCT
iajs-2271	60	38	pathologic	pathologic	ADJ
iajs-2271	60	39	”	"	PUNCT
iajs-2271	60	40	component	component	NOUN
iajs-2271	60	41	of	of	ADP
iajs-2271	60	42	the	the	DET
iajs-2271	60	43	“	"	PUNCT
iajs-2271	60	44	pathways	pathway	NOUN
iajs-2271	60	45	tools	tool	NOUN
iajs-2271	60	46	”	"	PUNCT
iajs-2271	60	47	software	software	NOUN
iajs-2271	60	48	.	.	PUNCT
iajs-2271	61	1	the	the	DET
iajs-2271	61	2	pathway	pathway	NOUN
iajs-2271	61	3	/	/	SYM
iajs-2271	61	4	genome	genome	NOUN
iajs-2271	61	5	navigator	navigator	NOUN
iajs-2271	61	6	component	component	NOUN
iajs-2271	61	7	provides	provide	VERB
iajs-2271	61	8	query	query	NOUN
iajs-2271	61	9	,	,	PUNCT
iajs-2271	61	10	visualization	visualization	NOUN
iajs-2271	61	11	,	,	PUNCT
iajs-2271	61	12	and	and	CCONJ
iajs-2271	61	13	web	web	NOUN
iajs-2271	61	14	-	-	ADJ
iajs-2271	61	15	publishing	publishing	ADJ
iajs-2271	61	16	services	service	NOUN
iajs-2271	61	17	for	for	ADP
iajs-2271	61	18	pgdbs	pgdbs	NOUN
iajs-2271	61	19	.	.	PUNCT
iajs-2271	62	1	the	the	DET
iajs-2271	62	2	pathway	pathway	NOUN
iajs-2271	62	3	/	/	SYM
iajs-2271	62	4	genome	genome	NOUN
iajs-2271	62	5	“	"	PUNCT
iajs-2271	62	6	editors	editor	NOUN
iajs-2271	62	7	”	"	PUNCT
iajs-2271	62	8	were	be	AUX
iajs-2271	62	9	used	use	VERB
iajs-2271	62	10	for	for	ADP
iajs-2271	62	11	curation	curation	NOUN
iajs-2271	62	12	and	and	CCONJ
iajs-2271	62	13	interactive	interactive	ADJ
iajs-2271	62	14	updating	updating	NOUN
iajs-2271	62	15	of	of	ADP
iajs-2271	62	16	the	the	DET
iajs-2271	62	17	created	create	VERB
iajs-2271	62	18	pgdb	pgdb	NOUN
iajs-2271	62	19	.	.	PUNCT
iajs-2271	63	1	the	the	DET
iajs-2271	63	2	editors	editor	NOUN
iajs-2271	63	3	are	be	AUX
iajs-2271	63	4	pathway	pathway	NOUN
iajs-2271	63	5	editor	editor	NOUN
iajs-2271	63	6	,	,	PUNCT
iajs-2271	63	7	reaction	reaction	NOUN
iajs-2271	63	8	editor	editor	NOUN
iajs-2271	63	9	,	,	PUNCT
iajs-2271	63	10	protein	protein	NOUN
iajs-2271	63	11	editor	editor	NOUN
iajs-2271	63	12	...	...	PUNCT
iajs-2271	63	13	etc	etc	X
iajs-2271	63	14	.	.	X
iajs-2271	64	1	the	the	DET
iajs-2271	64	2	“	"	PUNCT
iajs-2271	64	3	pathway	pathway	NOUN
iajs-2271	64	4	tools	tool	NOUN
iajs-2271	64	5	”	"	PUNCT
iajs-2271	64	6	used	use	VERB
iajs-2271	64	7	metacyc	metacyc	NOUN
iajs-2271	64	8	[	[	X
iajs-2271	64	9	7	7	NUM
iajs-2271	64	10	]	]	PUNCT
iajs-2271	64	11	.	.	PUNCT
iajs-2271	65	1	as	as	ADP
iajs-2271	65	2	a	a	DET
iajs-2271	65	3	reference	reference	NOUN
iajs-2271	65	4	database	database	NOUN
iajs-2271	65	5	in	in	ADP
iajs-2271	65	6	the	the	DET
iajs-2271	65	7	metabolic	metabolic	NOUN
iajs-2271	65	8	reconstruction	reconstruction	NOUN
iajs-2271	65	9	process	process	NOUN
iajs-2271	65	10	.	.	PUNCT
iajs-2271	66	1	metacyc	metacyc	NOUN
iajs-2271	66	2	is	be	AUX
iajs-2271	66	3	a	a	DET
iajs-2271	66	4	multi	multi	ADJ
iajs-2271	66	5	-	-	ADJ
iajs-2271	66	6	organism	organism	ADJ
iajs-2271	66	7	database	database	NOUN
iajs-2271	66	8	of	of	ADP
iajs-2271	66	9	experimentally	experimentally	ADV
iajs-2271	66	10	elucidated	elucidated	ADJ
iajs-2271	66	11	metabolic	metabolic	NOUN
iajs-2271	66	12	pathways	pathway	NOUN
iajs-2271	66	13	and	and	CCONJ
iajs-2271	66	14	the	the	DET
iajs-2271	66	15	associated	associated	ADJ
iajs-2271	66	16	enzymes	enzyme	NOUN
iajs-2271	66	17	as	as	ADV
iajs-2271	66	18	well	well	ADV
iajs-2271	66	19	as	as	ADP
iajs-2271	66	20	their	their	PRON
iajs-2271	66	21	commission	commission	NOUN
iajs-2271	66	22	(	(	PUNCT
iajs-2271	66	23	ec	ec	PROPN
iajs-2271	66	24	)	)	PUNCT
iajs-2271	66	25	numbers	number	NOUN
iajs-2271	66	26	.	.	PUNCT
iajs-2271	67	1	experimental	experimental	ADJ
iajs-2271	67	2	literature	literature	NOUN
iajs-2271	67	3	in	in	ADP
iajs-2271	67	4	metabolic	metabolic	NOUN
iajs-2271	67	5	pathways	pathway	NOUN
iajs-2271	67	6	of	of	ADP
iajs-2271	67	7	sulfolobus	sulfolobus	NOUN
iajs-2271	67	8	solfataricus	solfataricus	NOUN
iajs-2271	67	9	and	and	CCONJ
iajs-2271	67	10	other	other	ADJ
iajs-2271	67	11	closely	closely	ADV
iajs-2271	67	12	related	relate	VERB
iajs-2271	67	13	archaea	archaea	NOUN
iajs-2271	67	14	was	be	AUX
iajs-2271	67	15	used	use	VERB
iajs-2271	67	16	in	in	ADP
iajs-2271	67	17	the	the	DET
iajs-2271	67	18	pgdb	pgdb	NOUN
iajs-2271	67	19	curation	curation	NOUN
iajs-2271	67	20	process	process	NOUN
iajs-2271	67	21	.	.	PUNCT
iajs-2271	68	1	metabolic	metabolic	NOUN
iajs-2271	68	2	pathway	pathway	NOUN
iajs-2271	68	3	-	-	PUNCT
iajs-2271	68	4	specific	specific	ADJ
iajs-2271	68	5	databases	database	NOUN
iajs-2271	68	6	such	such	ADJ
iajs-2271	68	7	as	as	ADP
iajs-2271	68	8	kegg	kegg	NOUN
iajs-2271	68	9	[	[	X
iajs-2271	68	10	20,21	20,21	NUM
iajs-2271	68	11	]	]	PUNCT
iajs-2271	68	12	.	.	PUNCT
iajs-2271	69	1	were	be	AUX
iajs-2271	69	2	also	also	ADV
iajs-2271	69	3	used	use	VERB
iajs-2271	69	4	.	.	PUNCT
iajs-2271	70	1	pubmed	pubmed	PROPN
iajs-2271	70	2	,	,	PUNCT
iajs-2271	70	3	blast	blast	NOUN
iajs-2271	70	4	and	and	CCONJ
iajs-2271	70	5	clusters	cluster	NOUN
iajs-2271	70	6	of	of	ADP
iajs-2271	70	7	orthologous	orthologous	ADJ
iajs-2271	70	8	groups	group	NOUN
iajs-2271	70	9	(	(	PUNCT
iajs-2271	70	10	cogs	cog	NOUN
iajs-2271	70	11	)	)	PUNCT
iajs-2271	70	12	from	from	ADP
iajs-2271	70	13	(	(	PUNCT
iajs-2271	70	14	ncbi	ncbi	NOUN
iajs-2271	70	15	,	,	PUNCT
iajs-2271	70	16	(	(	PUNCT
iajs-2271	70	17	http://www.ncbi.nlm.nih.gov	http://www.ncbi.nlm.nih.gov	PROPN
iajs-2271	70	18	)	)	PUNCT
iajs-2271	70	19	were	be	AUX
iajs-2271	70	20	also	also	ADV
iajs-2271	70	21	used	use	VERB
iajs-2271	70	22	in	in	ADP
iajs-2271	70	23	the	the	DET
iajs-2271	70	24	curation	curation	NOUN
iajs-2271	70	25	.	.	PUNCT
iajs-2271	71	1	other	other	ADJ
iajs-2271	71	2	databases	database	NOUN
iajs-2271	71	3	such	such	ADJ
iajs-2271	71	4	as	as	ADP
iajs-2271	71	5	the	the	DET
iajs-2271	71	6	enzyme	enzyme	NOUN
iajs-2271	71	7	database	database	NOUN
iajs-2271	71	8	brenda	brenda	NOUN
iajs-2271	71	9	(	(	PUNCT
iajs-2271	71	10	https://www.brenda-enzymes.org	https://www.brenda-enzymes.org	PROPN
iajs-2271	71	11	)	)	PUNCT
iajs-2271	71	12	,	,	PUNCT
iajs-2271	71	13	uniprot	uniprot	ADJ
iajs-2271	71	14	(	(	PUNCT
iajs-2271	71	15	https://www.uniprot.org	https://www.uniprot.org	NUM
iajs-2271	71	16	)	)	PUNCT
iajs-2271	71	17	and	and	CCONJ
iajs-2271	71	18	the	the	DET
iajs-2271	71	19	protein	protein	NOUN
iajs-2271	71	20	information	information	NOUN
iajs-2271	71	21	resource	resource	NOUN
iajs-2271	71	22	(	(	PUNCT
iajs-2271	71	23	pir	pir	PROPN
iajs-2271	71	24	)	)	PUNCT
iajs-2271	71	25	(	(	PUNCT
iajs-2271	71	26	http://pir.georgetown.edu	http://pir.georgetown.edu	X
iajs-2271	71	27	)	)	PUNCT
iajs-2271	71	28	were	be	AUX
iajs-2271	71	29	used	use	VERB
iajs-2271	71	30	as	as	ADV
iajs-2271	71	31	well	well	ADV
iajs-2271	71	32	.	.	PUNCT
iajs-2271	72	1	https://biocyc.org/organism-summary?object=ssol273057	https://biocyc.org/organism-summary?object=ssol273057	NOUN
iajs-2271	72	2	http://www.ncbi.nlm.nih.gov/	http://www.ncbi.nlm.nih.gov/	PRON
iajs-2271	72	3	https://www.brenda-enzymes.org/	https://www.brenda-enzymes.org/	X
iajs-2271	72	4	https://www.uniprot.org/	https://www.uniprot.org/	X
iajs-2271	72	5	http://pir.georgetown.edu/	http://pir.georgetown.edu/	VERB
iajs-2271	72	6	4	4	NUM
iajs-2271	72	7	ibn	ibn	PROPN
iajs-2271	72	8	al	al	PROPN
iajs-2271	72	9	-	-	PUNCT
iajs-2271	72	10	haitham	haitham	PROPN
iajs-2271	72	11	jour	jour	X
iajs-2271	72	12	.	.	PROPN
iajs-2271	73	1	for	for	ADP
iajs-2271	73	2	pure	pure	ADJ
iajs-2271	73	3	&	&	CCONJ
iajs-2271	73	4	appl	appl	PROPN
iajs-2271	73	5	.	.	PUNCT
iajs-2271	74	1	sci	sci	PROPN
iajs-2271	74	2	.	.	PROPN
iajs-2271	74	3	32	32	NUM
iajs-2271	74	4	(	(	PUNCT
iajs-2271	74	5	3	3	NUM
iajs-2271	74	6	)	)	PUNCT
iajs-2271	74	7	2019	2019	NUM
iajs-2271	74	8	2.2	2.2	NUM
iajs-2271	74	9	.	.	PUNCT
iajs-2271	75	1	missing	miss	VERB
iajs-2271	75	2	enzymes	enzyme	NOUN
iajs-2271	75	3	detection	detection	NOUN
iajs-2271	75	4	the	the	DET
iajs-2271	75	5	manual	manual	ADJ
iajs-2271	75	6	curation	curation	NOUN
iajs-2271	75	7	of	of	ADP
iajs-2271	75	8	the	the	DET
iajs-2271	75	9	initial	initial	ADJ
iajs-2271	75	10	sulfolobus	sulfolobus	NOUN
iajs-2271	75	11	solfataricus	solfataricus	ADJ
iajs-2271	75	12	p2	p2	PROPN
iajs-2271	75	13	pgdb	pgdb	NOUN
iajs-2271	75	14	was	be	AUX
iajs-2271	75	15	initiated	initiate	VERB
iajs-2271	75	16	with	with	ADP
iajs-2271	75	17	the	the	DET
iajs-2271	75	18	literature	literature	NOUN
iajs-2271	75	19	search	search	NOUN
iajs-2271	75	20	for	for	ADP
iajs-2271	75	21	amino	amino	NOUN
iajs-2271	75	22	acid	acid	NOUN
iajs-2271	75	23	biosynthetic	biosynthetic	ADJ
iajs-2271	75	24	pathways	pathway	NOUN
iajs-2271	75	25	,	,	PUNCT
iajs-2271	75	26	their	their	PRON
iajs-2271	75	27	reactions	reaction	NOUN
iajs-2271	75	28	,	,	PUNCT
iajs-2271	75	29	reactants	reactant	NOUN
iajs-2271	75	30	and	and	CCONJ
iajs-2271	75	31	the	the	DET
iajs-2271	75	32	involving	involve	VERB
iajs-2271	75	33	enzymes	enzyme	NOUN
iajs-2271	75	34	.	.	PUNCT
iajs-2271	76	1	by	by	ADP
iajs-2271	76	2	comparing	compare	VERB
iajs-2271	76	3	the	the	DET
iajs-2271	76	4	reaction	reaction	NOUN
iajs-2271	76	5	sets	set	NOUN
iajs-2271	76	6	,	,	PUNCT
iajs-2271	76	7	reactants	reactant	NOUN
iajs-2271	76	8	and	and	CCONJ
iajs-2271	76	9	the	the	DET
iajs-2271	76	10	enzymes	enzyme	NOUN
iajs-2271	76	11	,	,	PUNCT
iajs-2271	76	12	identified	identify	VERB
iajs-2271	76	13	by	by	ADP
iajs-2271	76	14	wet	wet	ADJ
iajs-2271	76	15	-	-	PUNCT
iajs-2271	76	16	lab	lab	NOUN
iajs-2271	76	17	experimental	experimental	ADJ
iajs-2271	76	18	literature	literature	NOUN
iajs-2271	76	19	to	to	ADP
iajs-2271	76	20	those	those	PRON
iajs-2271	76	21	in	in	ADP
iajs-2271	76	22	metacyc	metacyc	NOUN
iajs-2271	76	23	and	and	CCONJ
iajs-2271	76	24	the	the	DET
iajs-2271	76	25	created	create	VERB
iajs-2271	76	26	sulfolobus	sulfolobus	NOUN
iajs-2271	76	27	solfataricus	solfataricus	ADJ
iajs-2271	76	28	p2	p2	PROPN
iajs-2271	76	29	pgdb	pgdb	PROPN
iajs-2271	76	30	,	,	PUNCT
iajs-2271	76	31	enabled	enable	VERB
iajs-2271	76	32	identifying	identify	VERB
iajs-2271	76	33	the	the	DET
iajs-2271	76	34	missing	miss	VERB
iajs-2271	76	35	steps	step	NOUN
iajs-2271	76	36	and	and	CCONJ
iajs-2271	76	37	enzymes	enzyme	NOUN
iajs-2271	76	38	in	in	ADP
iajs-2271	76	39	the	the	DET
iajs-2271	76	40	pathways	pathway	NOUN
iajs-2271	76	41	(	(	PUNCT
iajs-2271	76	42	pathway	pathway	NOUN
iajs-2271	76	43	holes	hole	NOUN
iajs-2271	76	44	)	)	PUNCT
iajs-2271	76	45	.	.	PUNCT
iajs-2271	77	1	known	know	VERB
iajs-2271	77	2	ec	ec	PROPN
iajs-2271	77	3	numbers	number	NOUN
iajs-2271	77	4	of	of	ADP
iajs-2271	77	5	the	the	DET
iajs-2271	77	6	missing	miss	VERB
iajs-2271	77	7	reactions	reaction	NOUN
iajs-2271	77	8	helped	help	VERB
iajs-2271	77	9	in	in	ADP
iajs-2271	77	10	filling	fill	VERB
iajs-2271	77	11	the	the	DET
iajs-2271	77	12	missing	miss	VERB
iajs-2271	77	13	steps	step	NOUN
iajs-2271	77	14	depending	depend	VERB
iajs-2271	77	15	on	on	ADP
iajs-2271	77	16	the	the	DET
iajs-2271	77	17	available	available	ADJ
iajs-2271	77	18	experimental	experimental	ADJ
iajs-2271	77	19	literature	literature	NOUN
iajs-2271	77	20	in	in	ADP
iajs-2271	77	21	metabolic	metabolic	NOUN
iajs-2271	77	22	pathways	pathway	NOUN
iajs-2271	77	23	of	of	ADP
iajs-2271	77	24	sulfolobus	sulfolobus	NOUN
iajs-2271	77	25	solfataricus	solfataricus	NOUN
iajs-2271	77	26	,	,	PUNCT
iajs-2271	77	27	and	and	CCONJ
iajs-2271	77	28	then	then	ADV
iajs-2271	77	29	the	the	DET
iajs-2271	77	30	corresponding	correspond	VERB
iajs-2271	77	31	proteins	protein	NOUN
iajs-2271	77	32	and	and	CCONJ
iajs-2271	77	33	their	their	PRON
iajs-2271	77	34	encoding	encoding	NOUN
iajs-2271	77	35	genes	gene	NOUN
iajs-2271	77	36	were	be	AUX
iajs-2271	77	37	assigned	assign	VERB
iajs-2271	77	38	to	to	ADP
iajs-2271	77	39	these	these	DET
iajs-2271	77	40	reactions	reaction	NOUN
iajs-2271	77	41	.	.	PUNCT
iajs-2271	78	1	adopting	adopt	VERB
iajs-2271	78	2	one	one	NUM
iajs-2271	78	3	or	or	CCONJ
iajs-2271	78	4	more	more	ADJ
iajs-2271	78	5	of	of	ADP
iajs-2271	78	6	the	the	DET
iajs-2271	78	7	protein	protein	NOUN
iajs-2271	78	8	function	function	NOUN
iajs-2271	78	9	prediction	prediction	NOUN
iajs-2271	78	10	methods	method	NOUN
iajs-2271	78	11	(	(	PUNCT
iajs-2271	78	12	see	see	VERB
iajs-2271	78	13	below	below	ADV
iajs-2271	78	14	)	)	PUNCT
iajs-2271	78	15	,	,	PUNCT
iajs-2271	78	16	was	be	AUX
iajs-2271	78	17	the	the	DET
iajs-2271	78	18	alternative	alternative	NOUN
iajs-2271	78	19	for	for	ADP
iajs-2271	78	20	the	the	DET
iajs-2271	78	21	lack	lack	NOUN
iajs-2271	78	22	of	of	ADP
iajs-2271	78	23	experimental	experimental	ADJ
iajs-2271	78	24	literature	literature	NOUN
iajs-2271	78	25	.	.	PUNCT
iajs-2271	79	1	homology	homology	NOUN
iajs-2271	79	2	search	search	NOUN
iajs-2271	79	3	using	use	VERB
iajs-2271	79	4	blastp	blastp	NOUN
iajs-2271	79	5	programme	programme	NOUN
iajs-2271	79	6	and	and	CCONJ
iajs-2271	79	7	psi	psi	NOUN
iajs-2271	79	8	-	-	PUNCT
iajs-2271	79	9	blast	blast	NOUN
iajs-2271	79	10	[	[	X
iajs-2271	79	11	22	22	NUM
iajs-2271	79	12	]	]	PUNCT
iajs-2271	79	13	.	.	PUNCT
iajs-2271	80	1	for	for	ADP
iajs-2271	80	2	a	a	DET
iajs-2271	80	3	specific	specific	ADJ
iajs-2271	80	4	enzyme	enzyme	NOUN
iajs-2271	80	5	with	with	ADP
iajs-2271	80	6	an	an	DET
iajs-2271	80	7	assigned	assign	VERB
iajs-2271	80	8	ec	ec	NOUN
iajs-2271	80	9	-	-	PUNCT
iajs-2271	80	10	number	number	NOUN
iajs-2271	80	11	(	(	PUNCT
iajs-2271	80	12	its	its	PRON
iajs-2271	80	13	sequence	sequence	NOUN
iajs-2271	80	14	has	have	AUX
iajs-2271	80	15	been	be	AUX
iajs-2271	80	16	retrieved	retrieve	VERB
iajs-2271	80	17	from	from	ADP
iajs-2271	80	18	closely	closely	ADV
iajs-2271	80	19	related	relate	VERB
iajs-2271	80	20	archaea	archaea	NOUN
iajs-2271	80	21	)	)	PUNCT
iajs-2271	80	22	in	in	ADP
iajs-2271	80	23	sulfolobus	sulfolobus	NOUN
iajs-2271	80	24	solfataricus	solfataricus	ADJ
iajs-2271	80	25	p2	p2	NOUN
iajs-2271	80	26	genome	genome	NOUN
iajs-2271	80	27	was	be	AUX
iajs-2271	80	28	the	the	DET
iajs-2271	80	29	main	main	ADJ
iajs-2271	80	30	strategy	strategy	NOUN
iajs-2271	80	31	in	in	ADP
iajs-2271	80	32	this	this	DET
iajs-2271	80	33	step	step	NOUN
iajs-2271	80	34	.	.	PUNCT
iajs-2271	81	1	clusters	cluster	NOUN
iajs-2271	81	2	of	of	ADP
iajs-2271	81	3	orthologous	orthologous	ADJ
iajs-2271	81	4	groups	group	NOUN
iajs-2271	81	5	of	of	ADP
iajs-2271	81	6	proteins	protein	NOUN
iajs-2271	81	7	(	(	PUNCT
iajs-2271	81	8	cogs	cog	NOUN
iajs-2271	81	9	)	)	PUNCT
iajs-2271	81	10	(	(	PUNCT
iajs-2271	81	11	http://www.ncbi.nlm.nih.gov/cog/	http://www.ncbi.nlm.nih.gov/cog/	NOUN
iajs-2271	81	12	)	)	PUNCT
iajs-2271	81	13	were	be	AUX
iajs-2271	81	14	used	use	VERB
iajs-2271	81	15	to	to	PART
iajs-2271	81	16	identify	identify	VERB
iajs-2271	81	17	the	the	DET
iajs-2271	81	18	potential	potential	ADJ
iajs-2271	81	19	candidates	candidate	NOUN
iajs-2271	81	20	for	for	ADP
iajs-2271	81	21	the	the	DET
iajs-2271	81	22	pathway	pathway	NOUN
iajs-2271	81	23	holes	hole	NOUN
iajs-2271	81	24	(	(	PUNCT
iajs-2271	81	25	see	see	VERB
iajs-2271	81	26	[	[	X
iajs-2271	81	27	23	23	NUM
iajs-2271	81	28	]	]	NUM
iajs-2271	81	29	)	)	PUNCT
iajs-2271	81	30	.	.	PUNCT
iajs-2271	82	1	the	the	DET
iajs-2271	82	2	study	study	NOUN
iajs-2271	82	3	of	of	ADP
iajs-2271	82	4	corresponding	correspond	VERB
iajs-2271	82	5	pathways	pathway	NOUN
iajs-2271	82	6	in	in	ADP
iajs-2271	82	7	phylogenetically	phylogenetically	ADV
iajs-2271	82	8	close	close	ADV
iajs-2271	82	9	-	-	PUNCT
iajs-2271	82	10	related	relate	VERB
iajs-2271	82	11	species	specie	NOUN
iajs-2271	82	12	to	to	PART
iajs-2271	82	13	sulfolobus	sulfolobus	VERB
iajs-2271	82	14	solfataricus	solfataricus	NOUN
iajs-2271	82	15	helped	help	VERB
iajs-2271	82	16	in	in	ADP
iajs-2271	82	17	filling	fill	VERB
iajs-2271	82	18	the	the	DET
iajs-2271	82	19	gaps	gap	NOUN
iajs-2271	82	20	and	and	CCONJ
iajs-2271	82	21	also	also	ADV
iajs-2271	82	22	creating	create	VERB
iajs-2271	82	23	some	some	DET
iajs-2271	82	24	other	other	ADJ
iajs-2271	82	25	pathway	pathway	NOUN
iajs-2271	82	26	variants	variant	NOUN
iajs-2271	82	27	in	in	ADP
iajs-2271	82	28	the	the	DET
iajs-2271	82	29	sulfolobus	sulfolobus	ADJ
iajs-2271	82	30	solfataricus	solfataricus	ADJ
iajs-2271	82	31	p2	p2	PROPN
iajs-2271	82	32	pgdb	pgdb	NOUN
iajs-2271	82	33	.	.	PUNCT
iajs-2271	83	1	identification	identification	NOUN
iajs-2271	83	2	of	of	ADP
iajs-2271	83	3	the	the	DET
iajs-2271	83	4	subunits	subunit	NOUN
iajs-2271	83	5	of	of	ADP
iajs-2271	83	6	the	the	DET
iajs-2271	83	7	enzyme	enzyme	NOUN
iajs-2271	83	8	complexes	complex	NOUN
iajs-2271	83	9	was	be	AUX
iajs-2271	83	10	also	also	ADV
iajs-2271	83	11	included	include	VERB
iajs-2271	83	12	in	in	ADP
iajs-2271	83	13	the	the	DET
iajs-2271	83	14	curation	curation	NOUN
iajs-2271	83	15	to	to	PART
iajs-2271	83	16	give	give	VERB
iajs-2271	83	17	a	a	DET
iajs-2271	83	18	complete	complete	ADJ
iajs-2271	83	19	view	view	NOUN
iajs-2271	83	20	of	of	ADP
iajs-2271	83	21	some	some	DET
iajs-2271	83	22	reactions	reaction	NOUN
iajs-2271	83	23	that	that	PRON
iajs-2271	83	24	are	be	AUX
iajs-2271	83	25	catalyzed	catalyze	VERB
iajs-2271	83	26	by	by	ADP
iajs-2271	83	27	complexes	complex	NOUN
iajs-2271	83	28	.	.	PUNCT
iajs-2271	84	1	the	the	DET
iajs-2271	84	2	predicted	predict	VERB
iajs-2271	84	3	missing	miss	VERB
iajs-2271	84	4	enzymes	enzyme	NOUN
iajs-2271	84	5	and	and	CCONJ
iajs-2271	84	6	the	the	DET
iajs-2271	84	7	encoding	encoding	NOUN
iajs-2271	84	8	genes	gene	NOUN
iajs-2271	84	9	were	be	AUX
iajs-2271	84	10	assigned	assign	VERB
iajs-2271	84	11	to	to	ADP
iajs-2271	84	12	the	the	DET
iajs-2271	84	13	corresponding	corresponding	ADJ
iajs-2271	84	14	reactions	reaction	NOUN
iajs-2271	84	15	via	via	ADP
iajs-2271	84	16	the	the	DET
iajs-2271	84	17	“	"	PUNCT
iajs-2271	84	18	editors	editor	NOUN
iajs-2271	84	19	”	"	PUNCT
iajs-2271	84	20	component	component	NOUN
iajs-2271	84	21	of	of	ADP
iajs-2271	84	22	“	"	PUNCT
iajs-2271	84	23	pathway	pathway	NOUN
iajs-2271	84	24	tools	tool	NOUN
iajs-2271	84	25	”	"	PUNCT
iajs-2271	84	26	software	software	NOUN
iajs-2271	84	27	.	.	PUNCT
iajs-2271	85	1	2.3	2.3	NUM
iajs-2271	85	2	.	.	X
iajs-2271	85	3	protein	protein	NOUN
iajs-2271	85	4	function	function	NOUN
iajs-2271	85	5	prediction	prediction	NOUN
iajs-2271	85	6	in	in	ADP
iajs-2271	85	7	order	order	NOUN
iajs-2271	85	8	to	to	PART
iajs-2271	85	9	assign	assign	VERB
iajs-2271	85	10	function	function	NOUN
iajs-2271	85	11	to	to	ADP
iajs-2271	85	12	an	an	DET
iajs-2271	85	13	enzyme	enzyme	NOUN
iajs-2271	85	14	,	,	PUNCT
iajs-2271	85	15	one	one	NUM
iajs-2271	85	16	or	or	CCONJ
iajs-2271	85	17	a	a	DET
iajs-2271	85	18	combination	combination	NOUN
iajs-2271	85	19	of	of	ADP
iajs-2271	85	20	the	the	DET
iajs-2271	85	21	following	follow	VERB
iajs-2271	85	22	approaches	approach	NOUN
iajs-2271	85	23	were	be	AUX
iajs-2271	85	24	applied	apply	VERB
iajs-2271	85	25	during	during	ADP
iajs-2271	85	26	the	the	DET
iajs-2271	85	27	reconstruction	reconstruction	NOUN
iajs-2271	85	28	and	and	CCONJ
iajs-2271	85	29	curation	curation	NOUN
iajs-2271	85	30	of	of	ADP
iajs-2271	85	31	the	the	DET
iajs-2271	85	32	amino	amino	NOUN
iajs-2271	85	33	acid	acid	NOUN
iajs-2271	85	34	biosynthetic	biosynthetic	ADJ
iajs-2271	85	35	pathways	pathway	NOUN
iajs-2271	85	36	(	(	PUNCT
iajs-2271	85	37	see	see	VERB
iajs-2271	85	38	[	[	X
iajs-2271	85	39	24	24	NUM
iajs-2271	85	40	]	]	PUNCT
iajs-2271	85	41	)	)	PUNCT
iajs-2271	85	42	.	.	PUNCT
iajs-2271	86	1	a	a	DET
iajs-2271	86	2	)	)	PUNCT
iajs-2271	86	3	homology-	homology-	NOUN
iajs-2271	86	4	,	,	PUNCT
iajs-2271	86	5	orthology	orthology	NOUN
iajs-2271	86	6	-	-	PUNCT
iajs-2271	86	7	based	base	VERB
iajs-2271	86	8	function	function	NOUN
iajs-2271	86	9	prediction	prediction	NOUN
iajs-2271	86	10	;	;	PUNCT
iajs-2271	86	11	homology	homology	NOUN
iajs-2271	86	12	search	search	NOUN
iajs-2271	86	13	using	use	VERB
iajs-2271	86	14	a	a	DET
iajs-2271	86	15	protein	protein	NOUN
iajs-2271	86	16	sequence	sequence	NOUN
iajs-2271	86	17	of	of	ADP
iajs-2271	86	18	an	an	DET
iajs-2271	86	19	experimentally	experimentally	ADV
iajs-2271	86	20	validated	validate	VERB
iajs-2271	86	21	function	function	NOUN
iajs-2271	86	22	as	as	ADP
iajs-2271	86	23	a	a	DET
iajs-2271	86	24	query	query	NOUN
iajs-2271	86	25	to	to	PART
iajs-2271	86	26	find	find	VERB
iajs-2271	86	27	the	the	DET
iajs-2271	86	28	homologs	homolog	NOUN
iajs-2271	86	29	in	in	ADP
iajs-2271	86	30	the	the	DET
iajs-2271	86	31	target	target	NOUN
iajs-2271	86	32	organism	organism	NOUN
iajs-2271	86	33	genome	genome	NOUN
iajs-2271	86	34	helped	help	VERB
iajs-2271	86	35	in	in	ADP
iajs-2271	86	36	finding	find	VERB
iajs-2271	86	37	the	the	DET
iajs-2271	86	38	missing	miss	VERB
iajs-2271	86	39	enzymes	enzyme	NOUN
iajs-2271	86	40	for	for	ADP
iajs-2271	86	41	a	a	DET
iajs-2271	86	42	specific	specific	ADJ
iajs-2271	86	43	pathway	pathway	NOUN
iajs-2271	86	44	.	.	PUNCT
iajs-2271	87	1	the	the	DET
iajs-2271	87	2	detected	detect	VERB
iajs-2271	87	3	homologs	homolog	NOUN
iajs-2271	87	4	likely	likely	ADJ
iajs-2271	87	5	and	and	CCONJ
iajs-2271	87	6	not	not	PART
iajs-2271	87	7	necessarily	necessarily	ADV
iajs-2271	87	8	have	have	VERB
iajs-2271	87	9	the	the	DET
iajs-2271	87	10	same	same	ADJ
iajs-2271	87	11	function	function	NOUN
iajs-2271	87	12	as	as	ADP
iajs-2271	87	13	the	the	DET
iajs-2271	87	14	query	query	NOUN
iajs-2271	87	15	,	,	PUNCT
iajs-2271	87	16	that	that	PRON
iajs-2271	87	17	is	be	AUX
iajs-2271	87	18	why	why	SCONJ
iajs-2271	87	19	the	the	DET
iajs-2271	87	20	orthology	orthology	NOUN
iajs-2271	87	21	is	be	AUX
iajs-2271	87	22	adopted	adopt	VERB
iajs-2271	87	23	to	to	PART
iajs-2271	87	24	be	be	AUX
iajs-2271	87	25	the	the	DET
iajs-2271	87	26	primary	primary	ADJ
iajs-2271	87	27	step	step	NOUN
iajs-2271	87	28	for	for	ADP
iajs-2271	87	29	function	function	NOUN
iajs-2271	87	30	prediction	prediction	NOUN
iajs-2271	87	31	.	.	PUNCT
iajs-2271	88	1	the	the	DET
iajs-2271	88	2	orthologs	ortholog	NOUN
iajs-2271	88	3	being	be	AUX
iajs-2271	88	4	originally	originally	ADV
iajs-2271	88	5	one	one	NUM
iajs-2271	88	6	gene	gene	NOUN
iajs-2271	88	7	before	before	ADP
iajs-2271	88	8	speciation	speciation	NOUN
iajs-2271	88	9	,	,	PUNCT
iajs-2271	88	10	they	they	PRON
iajs-2271	88	11	likely	likely	ADV
iajs-2271	88	12	possess	possess	VERB
iajs-2271	88	13	the	the	DET
iajs-2271	88	14	similar	similar	ADJ
iajs-2271	88	15	function	function	NOUN
iajs-2271	88	16	.	.	PUNCT
iajs-2271	89	1	b	b	X
iajs-2271	89	2	)	)	PUNCT
iajs-2271	89	3	gene	gene	NOUN
iajs-2271	89	4	neighbourhood	neighbourhood	NOUN
iajs-2271	89	5	(	(	PUNCT
iajs-2271	89	6	context	context	NOUN
iajs-2271	89	7	-	-	PUNCT
iajs-2271	89	8	based	base	VERB
iajs-2271	89	9	function	function	NOUN
iajs-2271	89	10	prediction	prediction	NOUN
iajs-2271	89	11	)	)	PUNCT
iajs-2271	89	12	;	;	PUNCT
iajs-2271	89	13	in	in	ADP
iajs-2271	89	14	case	case	NOUN
iajs-2271	89	15	to	to	PART
iajs-2271	89	16	select	select	VERB
iajs-2271	89	17	which	which	DET
iajs-2271	89	18	paralog	paralog	NOUN
iajs-2271	89	19	to	to	PART
iajs-2271	89	20	be	be	AUX
iajs-2271	89	21	assigned	assign	VERB
iajs-2271	89	22	the	the	DET
iajs-2271	89	23	specific	specific	ADJ
iajs-2271	89	24	function	function	NOUN
iajs-2271	89	25	,	,	PUNCT
iajs-2271	89	26	the	the	DET
iajs-2271	89	27	physical	physical	ADJ
iajs-2271	89	28	position	position	NOUN
iajs-2271	89	29	of	of	ADP
iajs-2271	89	30	the	the	DET
iajs-2271	89	31	gene	gene	NOUN
iajs-2271	89	32	in	in	ADP
iajs-2271	89	33	the	the	DET
iajs-2271	89	34	genome	genome	NOUN
iajs-2271	89	35	was	be	AUX
iajs-2271	89	36	taken	take	VERB
iajs-2271	89	37	in	in	ADP
iajs-2271	89	38	consideration	consideration	NOUN
iajs-2271	89	39	.	.	PUNCT
iajs-2271	90	1	the	the	DET
iajs-2271	90	2	association	association	NOUN
iajs-2271	90	3	of	of	ADP
iajs-2271	90	4	a	a	DET
iajs-2271	90	5	specific	specific	ADJ
iajs-2271	90	6	paralog	paralog	NOUN
iajs-2271	90	7	or	or	CCONJ
iajs-2271	90	8	a	a	DET
iajs-2271	90	9	gene	gene	NOUN
iajs-2271	90	10	to	to	ADP
iajs-2271	90	11	a	a	DET
iajs-2271	90	12	set	set	NOUN
iajs-2271	90	13	of	of	ADP
iajs-2271	90	14	genes	gene	NOUN
iajs-2271	90	15	in	in	ADP
iajs-2271	90	16	a	a	DET
iajs-2271	90	17	specific	specific	ADJ
iajs-2271	90	18	operon	operon	NOUN
iajs-2271	90	19	performing	perform	VERB
iajs-2271	90	20	same	same	ADJ
iajs-2271	90	21	biological	biological	ADJ
iajs-2271	90	22	process	process	NOUN
iajs-2271	90	23	is	be	AUX
iajs-2271	90	24	likely	likely	ADJ
iajs-2271	90	25	to	to	PART
iajs-2271	90	26	be	be	AUX
iajs-2271	90	27	an	an	DET
iajs-2271	90	28	indicator	indicator	NOUN
iajs-2271	90	29	for	for	ADP
iajs-2271	90	30	the	the	DET
iajs-2271	90	31	performance	performance	NOUN
iajs-2271	90	32	of	of	ADP
iajs-2271	90	33	a	a	DET
iajs-2271	90	34	specific	specific	ADJ
iajs-2271	90	35	function	function	NOUN
iajs-2271	90	36	.	.	PUNCT
iajs-2271	91	1	the	the	DET
iajs-2271	91	2	evolutionary	evolutionary	ADJ
iajs-2271	91	3	conservation	conservation	NOUN
iajs-2271	91	4	of	of	ADP
iajs-2271	91	5	that	that	DET
iajs-2271	91	6	association	association	NOUN
iajs-2271	91	7	in	in	ADP
iajs-2271	91	8	different	different	ADJ
iajs-2271	91	9	species	specie	NOUN
iajs-2271	91	10	confirms	confirm	VERB
iajs-2271	91	11	the	the	DET
iajs-2271	91	12	approach	approach	NOUN
iajs-2271	91	13	.	.	PUNCT
iajs-2271	92	1	c	c	X
iajs-2271	92	2	)	)	PUNCT
iajs-2271	92	3	gene	gene	NOUN
iajs-2271	92	4	fusion	fusion	NOUN
iajs-2271	92	5	;	;	PUNCT
iajs-2271	92	6	detecting	detect	VERB
iajs-2271	92	7	subunits	subunit	NOUN
iajs-2271	92	8	of	of	ADP
iajs-2271	92	9	experimentally	experimentally	ADV
iajs-2271	92	10	known	know	VERB
iajs-2271	92	11	enzyme	enzyme	NOUN
iajs-2271	92	12	complexes	complex	NOUN
iajs-2271	92	13	via	via	ADP
iajs-2271	92	14	homology	homology	NOUN
iajs-2271	92	15	search	search	NOUN
iajs-2271	92	16	in	in	ADP
iajs-2271	92	17	the	the	DET
iajs-2271	92	18	target	target	NOUN
iajs-2271	92	19	genome	genome	NOUN
iajs-2271	92	20	gives	give	VERB
iajs-2271	92	21	strong	strong	ADJ
iajs-2271	92	22	evidence	evidence	NOUN
iajs-2271	92	23	that	that	SCONJ
iajs-2271	92	24	these	these	DET
iajs-2271	92	25	sequences	sequence	NOUN
iajs-2271	92	26	in	in	ADP
iajs-2271	92	27	the	the	DET
iajs-2271	92	28	target	target	NOUN
iajs-2271	92	29	organism	organism	NOUN
iajs-2271	92	30	perform	perform	VERB
iajs-2271	92	31	gene	gene	NOUN
iajs-2271	92	32	fusion	fusion	NOUN
iajs-2271	92	33	in	in	ADP
iajs-2271	92	34	order	order	NOUN
iajs-2271	92	35	to	to	PART
iajs-2271	92	36	create	create	VERB
iajs-2271	92	37	a	a	DET
iajs-2271	92	38	specific	specific	ADJ
iajs-2271	92	39	enzyme	enzyme	NOUN
iajs-2271	92	40	complex	complex	NOUN
iajs-2271	92	41	likely	likely	ADJ
iajs-2271	92	42	to	to	PART
iajs-2271	92	43	catalyze	catalyze	VERB
iajs-2271	92	44	the	the	DET
iajs-2271	92	45	same	same	ADJ
iajs-2271	92	46	reaction	reaction	NOUN
iajs-2271	92	47	.	.	PUNCT
iajs-2271	93	1	in	in	ADP
iajs-2271	93	2	some	some	DET
iajs-2271	93	3	cases	case	NOUN
iajs-2271	93	4	a	a	DET
iajs-2271	93	5	bifunctional	bifunctional	ADJ
iajs-2271	93	6	enzyme	enzyme	NOUN
iajs-2271	93	7	catalyzes	catalyze	VERB
iajs-2271	93	8	two	two	NUM
iajs-2271	93	9	different	different	ADJ
iajs-2271	93	10	steps	step	NOUN
iajs-2271	93	11	in	in	ADP
iajs-2271	93	12	a	a	DET
iajs-2271	93	13	specific	specific	ADJ
iajs-2271	93	14	pathway	pathway	NOUN
iajs-2271	93	15	in	in	ADP
iajs-2271	93	16	an	an	DET
iajs-2271	93	17	organism	organism	NOUN
iajs-2271	93	18	,	,	PUNCT
iajs-2271	93	19	while	while	SCONJ
iajs-2271	93	20	two	two	NUM
iajs-2271	93	21	different	different	ADJ
iajs-2271	93	22	genes	gene	NOUN
iajs-2271	93	23	catalyze	catalyze	VERB
iajs-2271	93	24	the	the	DET
iajs-2271	93	25	two	two	NUM
iajs-2271	93	26	different	different	ADJ
iajs-2271	93	27	steps	step	NOUN
iajs-2271	93	28	in	in	ADP
iajs-2271	93	29	another	another	DET
iajs-2271	93	30	organism	organism	NOUN
iajs-2271	93	31	.	.	PUNCT
iajs-2271	94	1	it	it	PRON
iajs-2271	94	2	is	be	AUX
iajs-2271	94	3	assumed	assume	VERB
iajs-2271	94	4	that	that	SCONJ
iajs-2271	94	5	the	the	DET
iajs-2271	94	6	bifunctional	bifunctional	ADJ
iajs-2271	94	7	enzyme	enzyme	NOUN
iajs-2271	94	8	is	be	AUX
iajs-2271	94	9	a	a	DET
iajs-2271	94	10	result	result	NOUN
iajs-2271	94	11	of	of	ADP
iajs-2271	94	12	gene	gene	NOUN
iajs-2271	94	13	fusion	fusion	NOUN
iajs-2271	94	14	between	between	ADP
iajs-2271	94	15	the	the	DET
iajs-2271	94	16	two	two	NUM
iajs-2271	94	17	homologs	homolog	NOUN
iajs-2271	94	18	of	of	ADP
iajs-2271	94	19	the	the	DET
iajs-2271	94	20	other	other	ADJ
iajs-2271	94	21	organism	organism	NOUN
iajs-2271	94	22	.	.	PUNCT
iajs-2271	95	1	d	d	X
iajs-2271	95	2	)	)	PUNCT
iajs-2271	95	3	phylogenetic	phylogenetic	ADJ
iajs-2271	95	4	distribution	distribution	NOUN
iajs-2271	95	5	(	(	PUNCT
iajs-2271	95	6	gene	gene	NOUN
iajs-2271	95	7	co	co	NOUN
iajs-2271	95	8	-	-	NOUN
iajs-2271	95	9	occurrence	occurrence	NOUN
iajs-2271	95	10	)	)	PUNCT
iajs-2271	95	11	;	;	PUNCT
iajs-2271	95	12	the	the	DET
iajs-2271	95	13	occurrence	occurrence	NOUN
iajs-2271	95	14	of	of	ADP
iajs-2271	95	15	genes	gene	NOUN
iajs-2271	95	16	of	of	ADP
iajs-2271	95	17	unknown	unknown	ADJ
iajs-2271	95	18	function	function	NOUN
iajs-2271	95	19	with	with	ADP
iajs-2271	95	20	other	other	ADJ
iajs-2271	95	21	functionally	functionally	ADV
iajs-2271	95	22	known	know	VERB
iajs-2271	95	23	genes	gene	NOUN
iajs-2271	95	24	in	in	ADP
iajs-2271	95	25	the	the	DET
iajs-2271	95	26	same	same	ADJ
iajs-2271	95	27	phylogenetic	phylogenetic	ADJ
iajs-2271	95	28	pattern	pattern	NOUN
iajs-2271	95	29	in	in	ADP
iajs-2271	95	30	different	different	ADJ
iajs-2271	95	31	species	specie	NOUN
iajs-2271	95	32	gives	give	VERB
iajs-2271	95	33	5	5	NUM
iajs-2271	95	34	ibn	ibn	PROPN
iajs-2271	95	35	al	al	PROPN
iajs-2271	95	36	-	-	PUNCT
iajs-2271	95	37	haitham	haitham	PROPN
iajs-2271	95	38	jour	jour	X
iajs-2271	95	39	.	.	PROPN
iajs-2271	95	40	for	for	ADP
iajs-2271	95	41	pure	pure	ADJ
iajs-2271	95	42	&	&	CCONJ
iajs-2271	95	43	appl	appl	PROPN
iajs-2271	95	44	.	.	PUNCT
iajs-2271	96	1	sci	sci	PROPN
iajs-2271	96	2	.	.	PROPN
iajs-2271	96	3	32	32	NUM
iajs-2271	96	4	(	(	PUNCT
iajs-2271	96	5	3	3	NUM
iajs-2271	96	6	)	)	SYM
iajs-2271	96	7	2019	2019	NUM
iajs-2271	96	8	indication	indication	NOUN
iajs-2271	96	9	to	to	ADP
iajs-2271	96	10	the	the	DET
iajs-2271	96	11	role	role	NOUN
iajs-2271	96	12	that	that	PRON
iajs-2271	96	13	gene	gene	NOUN
iajs-2271	96	14	may	may	AUX
iajs-2271	96	15	act	act	VERB
iajs-2271	96	16	.	.	PUNCT
iajs-2271	97	1	e	e	X
iajs-2271	97	2	)	)	PUNCT
iajs-2271	97	3	conservation	conservation	NOUN
iajs-2271	97	4	of	of	ADP
iajs-2271	97	5	co	co	NOUN
iajs-2271	97	6	-	-	NOUN
iajs-2271	97	7	expression	expression	NOUN
iajs-2271	97	8	;	;	PUNCT
iajs-2271	97	9	hierarchical	hierarchical	ADJ
iajs-2271	97	10	clustering	clustering	NOUN
iajs-2271	97	11	in	in	ADP
iajs-2271	97	12	the	the	DET
iajs-2271	97	13	gene	gene	NOUN
iajs-2271	97	14	expression	expression	NOUN
iajs-2271	97	15	profile	profile	NOUN
iajs-2271	97	16	studies	study	NOUN
iajs-2271	97	17	organized	organize	VERB
iajs-2271	97	18	genes	gene	NOUN
iajs-2271	97	19	in	in	ADP
iajs-2271	97	20	specific	specific	ADJ
iajs-2271	97	21	clusters	cluster	NOUN
iajs-2271	97	22	.	.	PUNCT
iajs-2271	98	1	the	the	DET
iajs-2271	98	2	occurrence	occurrence	NOUN
iajs-2271	98	3	of	of	ADP
iajs-2271	98	4	genes	gene	NOUN
iajs-2271	98	5	of	of	ADP
iajs-2271	98	6	unknown	unknown	ADJ
iajs-2271	98	7	functions	function	NOUN
iajs-2271	98	8	with	with	ADP
iajs-2271	98	9	genes	gene	NOUN
iajs-2271	98	10	of	of	ADP
iajs-2271	98	11	known	know	VERB
iajs-2271	98	12	functions	function	NOUN
iajs-2271	98	13	in	in	ADP
iajs-2271	98	14	same	same	ADJ
iajs-2271	98	15	cluster	cluster	NOUN
iajs-2271	98	16	may	may	AUX
iajs-2271	98	17	help	help	VERB
iajs-2271	98	18	in	in	ADP
iajs-2271	98	19	assigning	assign	VERB
iajs-2271	98	20	functions	function	NOUN
iajs-2271	98	21	to	to	ADP
iajs-2271	98	22	the	the	DET
iajs-2271	98	23	genes	gene	NOUN
iajs-2271	98	24	of	of	ADP
iajs-2271	98	25	unknown	unknown	ADJ
iajs-2271	98	26	function	function	NOUN
iajs-2271	98	27	.	.	PUNCT
iajs-2271	99	1	the	the	DET
iajs-2271	99	2	conservation	conservation	NOUN
iajs-2271	99	3	of	of	ADP
iajs-2271	99	4	this	this	DET
iajs-2271	99	5	co	co	ADJ
iajs-2271	99	6	-	-	NOUN
iajs-2271	99	7	expression	expression	ADJ
iajs-2271	99	8	pattern	pattern	NOUN
iajs-2271	99	9	in	in	ADP
iajs-2271	99	10	different	different	ADJ
iajs-2271	99	11	species	specie	NOUN
iajs-2271	99	12	validates	validate	VERB
iajs-2271	99	13	this	this	DET
iajs-2271	99	14	approach	approach	NOUN
iajs-2271	99	15	.	.	PUNCT
iajs-2271	100	1	3	3	X
iajs-2271	100	2	.	.	X
iajs-2271	100	3	results	result	NOUN
iajs-2271	100	4	and	and	CCONJ
iajs-2271	100	5	discussion	discussion	NOUN
iajs-2271	100	6	3.1	3.1	NUM
iajs-2271	100	7	.	.	PUNCT
iajs-2271	101	1	initial	initial	ADJ
iajs-2271	101	2	non	non	ADJ
iajs-2271	101	3	-	-	ADJ
iajs-2271	101	4	curated	curate	VERB
iajs-2271	101	5	pgdb	pgdb	NOUN
iajs-2271	101	6	of	of	ADP
iajs-2271	101	7	sulfolobus	sulfolobus	NOUN
iajs-2271	101	8	solfataricus	solfataricus	NOUN
iajs-2271	101	9	p2	p2	VERB
iajs-2271	101	10	the	the	DET
iajs-2271	101	11	pathway	pathway	NOUN
iajs-2271	101	12	/	/	SYM
iajs-2271	101	13	genome	genome	NOUN
iajs-2271	101	14	database	database	NOUN
iajs-2271	101	15	(	(	PUNCT
iajs-2271	101	16	pgdb	pgdb	PROPN
iajs-2271	101	17	)	)	PUNCT
iajs-2271	101	18	of	of	ADP
iajs-2271	101	19	sulfolobus	sulfolobus	ADJ
iajs-2271	101	20	solfataricus	solfataricus	ADJ
iajs-2271	101	21	p2	p2	NOUN
iajs-2271	101	22	that	that	PRON
iajs-2271	101	23	was	be	AUX
iajs-2271	101	24	created	create	VERB
iajs-2271	101	25	by	by	ADP
iajs-2271	101	26	the	the	DET
iajs-2271	101	27	pathologic	pathologic	ADJ
iajs-2271	101	28	component	component	NOUN
iajs-2271	101	29	of	of	ADP
iajs-2271	101	30	the	the	DET
iajs-2271	101	31	pathway	pathway	NOUN
iajs-2271	101	32	tools	tool	NOUN
iajs-2271	101	33	software	software	NOUN
iajs-2271	101	34	is	be	AUX
iajs-2271	101	35	a	a	DET
iajs-2271	101	36	collection	collection	NOUN
iajs-2271	101	37	of	of	ADP
iajs-2271	101	38	the	the	DET
iajs-2271	101	39	genomic	genomic	ADJ
iajs-2271	101	40	information	information	NOUN
iajs-2271	101	41	and	and	CCONJ
iajs-2271	101	42	the	the	DET
iajs-2271	101	43	reconstructed	reconstructed	ADJ
iajs-2271	101	44	metabolic	metabolic	NOUN
iajs-2271	101	45	pathways	pathway	NOUN
iajs-2271	101	46	of	of	ADP
iajs-2271	101	47	s.	s.	PROPN
iajs-2271	101	48	solfataricus	solfataricus	PROPN
iajs-2271	101	49	p2	p2	PROPN
iajs-2271	101	50	strain	strain	NOUN
iajs-2271	101	51	.	.	PUNCT
iajs-2271	102	1	the	the	DET
iajs-2271	102	2	pgdb	pgdb	NOUN
iajs-2271	102	3	is	be	AUX
iajs-2271	102	4	visualized	visualize	VERB
iajs-2271	102	5	,	,	PUNCT
iajs-2271	102	6	queried	query	VERB
iajs-2271	102	7	and	and	CCONJ
iajs-2271	102	8	can	can	AUX
iajs-2271	102	9	be	be	AUX
iajs-2271	102	10	edited	edit	VERB
iajs-2271	102	11	via	via	ADP
iajs-2271	102	12	the	the	DET
iajs-2271	102	13	pathway	pathway	NOUN
iajs-2271	102	14	tools	tool	NOUN
iajs-2271	102	15	.	.	PUNCT
iajs-2271	103	1	the	the	DET
iajs-2271	103	2	created	create	VERB
iajs-2271	103	3	pgdb	pgdb	NOUN
iajs-2271	103	4	is	be	AUX
iajs-2271	103	5	an	an	DET
iajs-2271	103	6	object	object	NOUN
iajs-2271	103	7	-	-	PUNCT
iajs-2271	103	8	oriented	orient	VERB
iajs-2271	103	9	database	database	NOUN
iajs-2271	103	10	since	since	SCONJ
iajs-2271	103	11	the	the	DET
iajs-2271	103	12	software	software	NOUN
iajs-2271	103	13	creates	create	VERB
iajs-2271	103	14	such	such	ADJ
iajs-2271	103	15	types	type	NOUN
iajs-2271	103	16	of	of	ADP
iajs-2271	103	17	databases	database	NOUN
iajs-2271	103	18	and	and	CCONJ
iajs-2271	103	19	not	not	PART
iajs-2271	103	20	simple	simple	ADJ
iajs-2271	103	21	rational	rational	ADJ
iajs-2271	103	22	databases	database	NOUN
iajs-2271	103	23	.	.	PUNCT
iajs-2271	104	1	all	all	DET
iajs-2271	104	2	components	component	NOUN
iajs-2271	104	3	of	of	ADP
iajs-2271	104	4	the	the	DET
iajs-2271	104	5	database	database	NOUN
iajs-2271	104	6	are	be	AUX
iajs-2271	104	7	represented	represent	VERB
iajs-2271	104	8	as	as	ADP
iajs-2271	104	9	frames	frame	NOUN
iajs-2271	104	10	in	in	ADP
iajs-2271	104	11	the	the	DET
iajs-2271	104	12	graphical	graphical	ADJ
iajs-2271	104	13	display	display	NOUN
iajs-2271	104	14	of	of	ADP
iajs-2271	104	15	the	the	DET
iajs-2271	104	16	programme	programme	NOUN
iajs-2271	104	17	.	.	PUNCT
iajs-2271	105	1	the	the	DET
iajs-2271	105	2	programme	programme	NOUN
iajs-2271	105	3	compared	compare	VERB
iajs-2271	105	4	all	all	DET
iajs-2271	105	5	the	the	DET
iajs-2271	105	6	genomic	genomic	ADJ
iajs-2271	105	7	information	information	NOUN
iajs-2271	105	8	of	of	ADP
iajs-2271	105	9	s.	s.	PROPN
iajs-2271	105	10	solfataricus	solfataricus	VERB
iajs-2271	105	11	especially	especially	ADV
iajs-2271	105	12	the	the	DET
iajs-2271	105	13	annotated	annotate	VERB
iajs-2271	105	14	ec	ec	PROPN
iajs-2271	105	15	numbers	number	NOUN
iajs-2271	105	16	and	and	CCONJ
iajs-2271	105	17	the	the	DET
iajs-2271	105	18	enzyme	enzyme	NOUN
iajs-2271	105	19	names	name	NOUN
iajs-2271	105	20	with	with	ADP
iajs-2271	105	21	those	those	PRON
iajs-2271	105	22	stored	store	VERB
iajs-2271	105	23	in	in	ADP
iajs-2271	105	24	the	the	DET
iajs-2271	105	25	reference	reference	NOUN
iajs-2271	105	26	database	database	NOUN
iajs-2271	105	27	metacyc	metacyc	PROPN
iajs-2271	105	28	.	.	PUNCT
iajs-2271	106	1	via	via	ADP
iajs-2271	106	2	pathologic	pathologic	ADJ
iajs-2271	106	3	algorithm	algorithm	NOUN
iajs-2271	106	4	,	,	PUNCT
iajs-2271	106	5	the	the	DET
iajs-2271	106	6	programme	programme	NOUN
iajs-2271	106	7	has	have	AUX
iajs-2271	106	8	predicted	predict	VERB
iajs-2271	106	9	all	all	DET
iajs-2271	106	10	reactions	reaction	NOUN
iajs-2271	106	11	that	that	PRON
iajs-2271	106	12	are	be	AUX
iajs-2271	106	13	probably	probably	ADV
iajs-2271	106	14	been	be	AUX
iajs-2271	106	15	catalyzed	catalyze	VERB
iajs-2271	106	16	by	by	ADP
iajs-2271	106	17	these	these	DET
iajs-2271	106	18	enzymes	enzyme	NOUN
iajs-2271	106	19	and	and	CCONJ
iajs-2271	106	20	then	then	ADV
iajs-2271	106	21	the	the	DET
iajs-2271	106	22	inferring	inferring	NOUN
iajs-2271	106	23	of	of	ADP
iajs-2271	106	24	the	the	DET
iajs-2271	106	25	corresponding	corresponding	ADJ
iajs-2271	106	26	candidate	candidate	NOUN
iajs-2271	106	27	metabolic	metabolic	NOUN
iajs-2271	106	28	pathways	pathway	NOUN
iajs-2271	106	29	for	for	ADP
iajs-2271	106	30	s.	s.	PROPN
iajs-2271	106	31	solfataricus	solfataricus	PROPN
iajs-2271	106	32	.	.	PUNCT
iajs-2271	107	1	according	accord	VERB
iajs-2271	107	2	to	to	ADP
iajs-2271	107	3	the	the	DET
iajs-2271	107	4	programme	programme	NOUN
iajs-2271	107	5	algorithm	algorithm	NOUN
iajs-2271	107	6	,	,	PUNCT
iajs-2271	107	7	a	a	DET
iajs-2271	107	8	pathway	pathway	NOUN
iajs-2271	107	9	is	be	AUX
iajs-2271	107	10	added	add	VERB
iajs-2271	107	11	to	to	ADP
iajs-2271	107	12	the	the	DET
iajs-2271	107	13	database	database	NOUN
iajs-2271	107	14	when	when	SCONJ
iajs-2271	107	15	half	half	DET
iajs-2271	107	16	or	or	CCONJ
iajs-2271	107	17	more	more	ADJ
iajs-2271	107	18	reactions	reaction	NOUN
iajs-2271	107	19	of	of	ADP
iajs-2271	107	20	that	that	DET
iajs-2271	107	21	pathway	pathway	NOUN
iajs-2271	107	22	could	could	AUX
iajs-2271	107	23	be	be	AUX
iajs-2271	107	24	detected	detect	VERB
iajs-2271	107	25	by	by	ADP
iajs-2271	107	26	the	the	DET
iajs-2271	107	27	pathologic	pathologic	NOUN
iajs-2271	107	28	.	.	PUNCT
iajs-2271	108	1	the	the	DET
iajs-2271	108	2	home	home	NOUN
iajs-2271	108	3	screen	screen	NOUN
iajs-2271	108	4	of	of	ADP
iajs-2271	108	5	the	the	DET
iajs-2271	108	6	pathway	pathway	NOUN
iajs-2271	108	7	tools	tool	NOUN
iajs-2271	108	8	shows	show	VERB
iajs-2271	108	9	the	the	DET
iajs-2271	108	10	list	list	NOUN
iajs-2271	108	11	of	of	ADP
iajs-2271	108	12	the	the	DET
iajs-2271	108	13	pgdbs	pgdbs	NOUN
iajs-2271	108	14	,	,	PUNCT
iajs-2271	108	15	including	include	VERB
iajs-2271	108	16	the	the	DET
iajs-2271	108	17	extra	extra	ADJ
iajs-2271	108	18	copies	copy	NOUN
iajs-2271	108	19	for	for	ADP
iajs-2271	108	20	manually	manually	ADJ
iajs-2271	108	21	curation	curation	NOUN
iajs-2271	108	22	in	in	ADP
iajs-2271	108	23	order	order	NOUN
iajs-2271	108	24	to	to	PART
iajs-2271	108	25	compare	compare	VERB
iajs-2271	108	26	the	the	DET
iajs-2271	108	27	initial	initial	ADJ
iajs-2271	108	28	pgdb	pgdb	NOUN
iajs-2271	108	29	with	with	ADP
iajs-2271	108	30	the	the	DET
iajs-2271	108	31	so	so	ADV
iajs-2271	108	32	far	far	ADV
iajs-2271	108	33	curated	curate	VERB
iajs-2271	108	34	one	one	NUM
iajs-2271	108	35	.	.	PUNCT
iajs-2271	109	1	initially	initially	ADV
iajs-2271	109	2	a	a	DET
iajs-2271	109	3	total	total	NOUN
iajs-2271	109	4	of	of	ADP
iajs-2271	109	5	159	159	NUM
iajs-2271	109	6	pathways	pathway	NOUN
iajs-2271	109	7	and	and	CCONJ
iajs-2271	109	8	787	787	NUM
iajs-2271	109	9	enzymatic	enzymatic	ADJ
iajs-2271	109	10	reactions	reaction	NOUN
iajs-2271	109	11	were	be	AUX
iajs-2271	109	12	predicted	predict	VERB
iajs-2271	109	13	.	.	PUNCT
iajs-2271	110	1	from	from	ADP
iajs-2271	110	2	3009	3009	NUM
iajs-2271	110	3	polypeptides	polypeptide	NOUN
iajs-2271	110	4	,	,	PUNCT
iajs-2271	110	5	582	582	NUM
iajs-2271	110	6	enzymes	enzyme	NOUN
iajs-2271	110	7	were	be	AUX
iajs-2271	110	8	detected	detect	VERB
iajs-2271	110	9	in	in	ADP
iajs-2271	110	10	the	the	DET
iajs-2271	110	11	genome	genome	NOUN
iajs-2271	110	12	.	.	PUNCT
iajs-2271	111	1	in	in	ADP
iajs-2271	111	2	this	this	DET
iajs-2271	111	3	approach	approach	NOUN
iajs-2271	111	4	the	the	DET
iajs-2271	111	5	pgdb	pgdb	NOUN
iajs-2271	111	6	was	be	AUX
iajs-2271	111	7	manually	manually	ADV
iajs-2271	111	8	curated	curate	VERB
iajs-2271	111	9	for	for	ADP
iajs-2271	111	10	the	the	DET
iajs-2271	111	11	amino	amino	NOUN
iajs-2271	111	12	acid	acid	NOUN
iajs-2271	111	13	biosynthetic	biosynthetic	ADJ
iajs-2271	111	14	pathways	pathway	NOUN
iajs-2271	111	15	.	.	PUNCT
iajs-2271	112	1	the	the	DET
iajs-2271	112	2	curation	curation	NOUN
iajs-2271	112	3	is	be	AUX
iajs-2271	112	4	not	not	PART
iajs-2271	112	5	only	only	ADV
iajs-2271	112	6	addition	addition	NOUN
iajs-2271	112	7	of	of	ADP
iajs-2271	112	8	extra	extra	ADJ
iajs-2271	112	9	pathways	pathway	NOUN
iajs-2271	112	10	,	,	PUNCT
iajs-2271	112	11	which	which	PRON
iajs-2271	112	12	are	be	AUX
iajs-2271	112	13	not	not	PART
iajs-2271	112	14	detected	detect	VERB
iajs-2271	112	15	by	by	ADP
iajs-2271	112	16	the	the	DET
iajs-2271	112	17	pathway	pathway	NOUN
iajs-2271	112	18	tools	tool	NOUN
iajs-2271	112	19	but	but	CCONJ
iajs-2271	112	20	the	the	DET
iajs-2271	112	21	user	user	NOUN
iajs-2271	112	22	may	may	AUX
iajs-2271	112	23	also	also	ADV
iajs-2271	112	24	eliminate	eliminate	VERB
iajs-2271	112	25	pathways	pathway	NOUN
iajs-2271	112	26	for	for	ADP
iajs-2271	112	27	which	which	PRON
iajs-2271	112	28	there	there	PRON
iajs-2271	112	29	is	be	VERB
iajs-2271	112	30	little	little	ADJ
iajs-2271	112	31	evidence	evidence	NOUN
iajs-2271	112	32	[	[	X
iajs-2271	112	33	25	25	NUM
iajs-2271	112	34	]	]	PUNCT
iajs-2271	112	35	.	.	PUNCT
iajs-2271	113	1	3.2	3.2	NUM
iajs-2271	113	2	.	.	PUNCT
iajs-2271	114	1	curation	curation	NOUN
iajs-2271	114	2	of	of	ADP
iajs-2271	114	3	amino	amino	NOUN
iajs-2271	114	4	acid	acid	NOUN
iajs-2271	114	5	biosynthetic	biosynthetic	ADJ
iajs-2271	114	6	pathways	pathway	NOUN
iajs-2271	114	7	pathologic	pathologic	NOUN
iajs-2271	114	8	could	could	AUX
iajs-2271	114	9	detect	detect	VERB
iajs-2271	114	10	many	many	ADJ
iajs-2271	114	11	amino	amino	NOUN
iajs-2271	114	12	acid	acid	NOUN
iajs-2271	114	13	biosynthetic	biosynthetic	ADJ
iajs-2271	114	14	pathways	pathway	NOUN
iajs-2271	114	15	including	include	VERB
iajs-2271	114	16	some	some	DET
iajs-2271	114	17	super	super	ADJ
iajs-2271	114	18	pathways	pathway	NOUN
iajs-2271	114	19	.	.	PUNCT
iajs-2271	115	1	the	the	DET
iajs-2271	115	2	super	super	ADJ
iajs-2271	115	3	pathways	pathway	NOUN
iajs-2271	115	4	list	list	NOUN
iajs-2271	115	5	consists	consist	VERB
iajs-2271	115	6	of	of	ADP
iajs-2271	115	7	many	many	ADJ
iajs-2271	115	8	amino	amino	ADJ
iajs-2271	115	9	acids	acid	NOUN
iajs-2271	115	10	groups	group	NOUN
iajs-2271	115	11	such	such	ADJ
iajs-2271	115	12	as	as	ADP
iajs-2271	115	13	the	the	DET
iajs-2271	115	14	aromatic	aromatic	ADJ
iajs-2271	115	15	and	and	CCONJ
iajs-2271	115	16	branched	branched	ADJ
iajs-2271	115	17	chain	chain	NOUN
iajs-2271	115	18	amino	amino	NOUN
iajs-2271	115	19	acids	acid	NOUN
iajs-2271	115	20	.	.	PUNCT
iajs-2271	116	1	on	on	ADP
iajs-2271	116	2	the	the	DET
iajs-2271	116	3	other	other	ADJ
iajs-2271	116	4	hand	hand	NOUN
iajs-2271	116	5	the	the	DET
iajs-2271	116	6	individual	individual	ADJ
iajs-2271	116	7	amino	amino	ADJ
iajs-2271	116	8	acids	acid	NOUN
iajs-2271	116	9	list	list	NOUN
iajs-2271	116	10	consists	consist	VERB
iajs-2271	116	11	of	of	ADP
iajs-2271	116	12	the	the	DET
iajs-2271	116	13	majority	majority	NOUN
iajs-2271	116	14	but	but	CCONJ
iajs-2271	116	15	not	not	PART
iajs-2271	116	16	all	all	DET
iajs-2271	116	17	amino	amino	NOUN
iajs-2271	116	18	acid	acid	NOUN
iajs-2271	116	19	biosynthetic	biosynthetic	ADJ
iajs-2271	116	20	pathways	pathway	NOUN
iajs-2271	116	21	.	.	PUNCT
iajs-2271	117	1	both	both	CCONJ
iajs-2271	117	2	the	the	DET
iajs-2271	117	3	super	super	ADJ
iajs-2271	117	4	and	and	CCONJ
iajs-2271	117	5	individual	individual	ADJ
iajs-2271	117	6	amino	amino	ADJ
iajs-2271	117	7	acids	acid	NOUN
iajs-2271	117	8	pathways	pathway	NOUN
iajs-2271	117	9	contain	contain	VERB
iajs-2271	117	10	many	many	ADJ
iajs-2271	117	11	metabolic	metabolic	NOUN
iajs-2271	117	12	holes	hole	NOUN
iajs-2271	117	13	(	(	PUNCT
iajs-2271	117	14	missing	miss	VERB
iajs-2271	117	15	enzymes	enzyme	NOUN
iajs-2271	117	16	)	)	PUNCT
iajs-2271	117	17	to	to	PART
iajs-2271	117	18	be	be	AUX
iajs-2271	117	19	filled	fill	VERB
iajs-2271	117	20	in	in	ADP
iajs-2271	117	21	during	during	ADP
iajs-2271	117	22	the	the	DET
iajs-2271	117	23	curation	curation	NOUN
iajs-2271	117	24	.	.	PUNCT
iajs-2271	118	1	3.2.1	3.2.1	X
iajs-2271	118	2	.	.	PUNCT
iajs-2271	118	3	aromatic	aromatic	ADJ
iajs-2271	118	4	amino	amino	NOUN
iajs-2271	118	5	acid	acid	NOUN
iajs-2271	118	6	biosynthetic	biosynthetic	ADJ
iajs-2271	118	7	pathways	pathway	NOUN
iajs-2271	118	8	(	(	PUNCT
iajs-2271	118	9	phenylalanine	phenylalanine	NOUN
iajs-2271	118	10	,	,	PUNCT
iajs-2271	118	11	tyrosine	tyrosine	NOUN
iajs-2271	118	12	and	and	CCONJ
iajs-2271	118	13	tryptophan	tryptophan	NOUN
iajs-2271	118	14	)	)	PUNCT
iajs-2271	118	15	in	in	ADP
iajs-2271	118	16	order	order	NOUN
iajs-2271	118	17	to	to	PART
iajs-2271	118	18	give	give	VERB
iajs-2271	118	19	more	more	ADV
iajs-2271	118	20	complete	complete	ADJ
iajs-2271	118	21	display	display	NOUN
iajs-2271	118	22	to	to	ADP
iajs-2271	118	23	the	the	DET
iajs-2271	118	24	super	super	ADJ
iajs-2271	118	25	pathway	pathway	NOUN
iajs-2271	118	26	of	of	ADP
iajs-2271	118	27	aromatic	aromatic	ADJ
iajs-2271	118	28	amino	amino	NOUN
iajs-2271	118	29	acids	acid	NOUN
iajs-2271	118	30	biosynthesis	biosynthesis	NOUN
iajs-2271	118	31	,	,	PUNCT
iajs-2271	118	32	a	a	DET
iajs-2271	118	33	new	new	ADJ
iajs-2271	118	34	version	version	NOUN
iajs-2271	118	35	of	of	ADP
iajs-2271	118	36	the	the	DET
iajs-2271	118	37	super	super	ADJ
iajs-2271	118	38	pathway	pathway	NOUN
iajs-2271	118	39	of	of	ADP
iajs-2271	118	40	phenylalanine	phenylalanine	NOUN
iajs-2271	118	41	,	,	PUNCT
iajs-2271	118	42	tyrosine	tyrosine	NOUN
iajs-2271	118	43	and	and	CCONJ
iajs-2271	118	44	tryptophan	tryptophan	NOUN
iajs-2271	118	45	biosynthesis	biosynthesis	NOUN
iajs-2271	118	46	was	be	AUX
iajs-2271	118	47	created	create	VERB
iajs-2271	118	48	.	.	PUNCT
iajs-2271	119	1	figure	figure	NOUN
iajs-2271	119	2	1	1	NUM
iajs-2271	119	3	.	.	PUNCT
iajs-2271	119	4	shows	show	VERB
iajs-2271	119	5	the	the	DET
iajs-2271	119	6	involvement	involvement	NOUN
iajs-2271	119	7	of	of	ADP
iajs-2271	119	8	the	the	DET
iajs-2271	119	9	three	three	NUM
iajs-2271	119	10	amino	amino	ADJ
iajs-2271	119	11	acids	acid	NOUN
iajs-2271	119	12	in	in	ADP
iajs-2271	119	13	the	the	DET
iajs-2271	119	14	super	super	ADJ
iajs-2271	119	15	pathway	pathway	NOUN
iajs-2271	119	16	,	,	PUNCT
iajs-2271	119	17	whereas	whereas	SCONJ
iajs-2271	119	18	the	the	DET
iajs-2271	119	19	super	super	ADJ
iajs-2271	119	20	pathway	pathway	NOUN
iajs-2271	119	21	of	of	ADP
iajs-2271	119	22	the	the	DET
iajs-2271	119	23	initial	initial	ADJ
iajs-2271	119	24	non	non	ADJ
iajs-2271	119	25	-	-	ADJ
iajs-2271	119	26	curated	curate	VERB
iajs-2271	119	27	pgdb	pgdb	NOUN
iajs-2271	119	28	contains	contain	VERB
iajs-2271	119	29	tryptophan	tryptophan	NOUN
iajs-2271	119	30	only	only	ADV
iajs-2271	119	31	.	.	PUNCT
iajs-2271	120	1	from	from	ADP
iajs-2271	120	2	chorismate	chorismate	NOUN
iajs-2271	120	3	,	,	PUNCT
iajs-2271	120	4	the	the	DET
iajs-2271	120	5	new	new	ADJ
iajs-2271	120	6	super	super	ADJ
iajs-2271	120	7	pathway	pathway	NOUN
iajs-2271	120	8	version	version	NOUN
iajs-2271	120	9	shows	show	VERB
iajs-2271	120	10	the	the	DET
iajs-2271	120	11	production	production	NOUN
iajs-2271	120	12	of	of	ADP
iajs-2271	120	13	the	the	DET
iajs-2271	120	14	three	three	NUM
iajs-2271	120	15	amino	amino	ADJ
iajs-2271	120	16	acids	acid	NOUN
iajs-2271	120	17	.	.	PUNCT
iajs-2271	121	1	in	in	ADP
iajs-2271	121	2	the	the	DET
iajs-2271	121	3	aromatic	aromatic	ADJ
iajs-2271	121	4	amino	amino	NOUN
iajs-2271	121	5	acids	acid	NOUN
iajs-2271	121	6	biosynthetic	biosynthetic	ADJ
iajs-2271	121	7	pathways	pathway	NOUN
iajs-2271	121	8	the	the	DET
iajs-2271	121	9	metabolic	metabolic	NOUN
iajs-2271	121	10	holes	hole	NOUN
iajs-2271	121	11	were	be	AUX
iajs-2271	121	12	identified	identify	VERB
iajs-2271	121	13	to	to	PART
iajs-2271	121	14	be	be	AUX
iajs-2271	121	15	:	:	PUNCT
iajs-2271	121	16	ec	ec	PROPN
iajs-2271	121	17	2.7.1.71	2.7.1.71	NUM
iajs-2271	121	18	(	(	PUNCT
iajs-2271	121	19	in	in	ADP
iajs-2271	121	20	chorismate	chorismate	NOUN
iajs-2271	121	21	synthesis	synthesis	NOUN
iajs-2271	121	22	)	)	PUNCT
iajs-2271	121	23	,	,	PUNCT
iajs-2271	121	24	ec	ec	PROPN
iajs-2271	121	25	2.6.1.5	2.6.1.5	NUM
iajs-2271	121	26	(	(	PUNCT
iajs-2271	121	27	in	in	ADP
iajs-2271	121	28	phenylalanine	phenylalanine	ADJ
iajs-2271	121	29	pathway	pathway	NOUN
iajs-2271	121	30	)	)	PUNCT
iajs-2271	121	31	and	and	CCONJ
iajs-2271	121	32	ec	ec	PROPN
iajs-2271	121	33	1.3.1.12	1.3.1.12	PROPN
iajs-2271	121	34	(	(	PUNCT
iajs-2271	121	35	in	in	ADP
iajs-2271	121	36	tyrosine	tyrosine	NOUN
iajs-2271	121	37	pathway	pathway	NOUN
iajs-2271	121	38	)	)	PUNCT
iajs-2271	121	39	table	table	NOUN
iajs-2271	121	40	1	1	NUM
iajs-2271	121	41	.	.	NUM
iajs-2271	121	42	6	6	NUM
iajs-2271	121	43	ibn	ibn	PROPN
iajs-2271	121	44	al	al	PROPN
iajs-2271	121	45	-	-	PUNCT
iajs-2271	121	46	haitham	haitham	PROPN
iajs-2271	121	47	jour	jour	X
iajs-2271	121	48	.	.	PROPN
iajs-2271	122	1	for	for	ADP
iajs-2271	122	2	pure	pure	ADJ
iajs-2271	122	3	&	&	CCONJ
iajs-2271	122	4	appl	appl	PROPN
iajs-2271	122	5	.	.	PUNCT
iajs-2271	123	1	sci	sci	PROPN
iajs-2271	123	2	.	.	PROPN
iajs-2271	123	3	32	32	NUM
iajs-2271	123	4	(	(	PUNCT
iajs-2271	123	5	3	3	NUM
iajs-2271	123	6	)	)	PUNCT
iajs-2271	123	7	2019	2019	NUM
iajs-2271	123	8	the	the	DET
iajs-2271	123	9	enzyme	enzyme	NOUN
iajs-2271	123	10	(	(	PUNCT
iajs-2271	123	11	ec	ec	PROPN
iajs-2271	123	12	2.7.1.71	2.7.1.71	PROPN
iajs-2271	123	13	)	)	PUNCT
iajs-2271	123	14	catalyzing	catalyze	VERB
iajs-2271	123	15	the	the	DET
iajs-2271	123	16	fifth	fifth	ADJ
iajs-2271	123	17	reaction	reaction	NOUN
iajs-2271	123	18	of	of	ADP
iajs-2271	123	19	the	the	DET
iajs-2271	123	20	seven	seven	NUM
iajs-2271	123	21	-	-	PUNCT
iajs-2271	123	22	step	step	NOUN
iajs-2271	123	23	chorismate	chorismate	NOUN
iajs-2271	123	24	synthesis	synthesis	NOUN
iajs-2271	123	25	pathway	pathway	NOUN
iajs-2271	123	26	is	be	AUX
iajs-2271	123	27	an	an	DET
iajs-2271	123	28	archaeal	archaeal	ADJ
iajs-2271	123	29	shikimate	shikimate	NOUN
iajs-2271	123	30	kinase	kinase	NOUN
iajs-2271	123	31	(	(	PUNCT
iajs-2271	123	32	member	member	NOUN
iajs-2271	123	33	of	of	ADP
iajs-2271	123	34	the	the	DET
iajs-2271	123	35	ghmp	ghmp	PROPN
iajs-2271	123	36	-	-	PUNCT
iajs-2271	123	37	kinase	kinase	PROPN
iajs-2271	123	38	family	family	NOUN
iajs-2271	123	39	)	)	PUNCT
iajs-2271	123	40	.	.	PUNCT
iajs-2271	124	1	chorismate	chorismate	PROPN
iajs-2271	124	2	is	be	AUX
iajs-2271	124	3	the	the	DET
iajs-2271	124	4	precursor	precursor	NOUN
iajs-2271	124	5	for	for	ADP
iajs-2271	124	6	the	the	DET
iajs-2271	124	7	three	three	NUM
iajs-2271	124	8	aromatic	aromatic	ADJ
iajs-2271	124	9	amino	amino	NOUN
iajs-2271	124	10	acids	acid	NOUN
iajs-2271	124	11	.	.	PUNCT
iajs-2271	125	1	chromosomal	chromosomal	ADJ
iajs-2271	125	2	clustering	clustering	NOUN
iajs-2271	125	3	of	of	ADP
iajs-2271	125	4	the	the	DET
iajs-2271	125	5	chorismate	chorismate	ADJ
iajs-2271	125	6	biosynthetic	biosynthetic	ADJ
iajs-2271	125	7	genes	gene	NOUN
iajs-2271	125	8	helped	help	VERB
iajs-2271	125	9	in	in	ADP
iajs-2271	125	10	identifying	identify	VERB
iajs-2271	125	11	the	the	DET
iajs-2271	125	12	candidate	candidate	NOUN
iajs-2271	125	13	gene	gene	NOUN
iajs-2271	125	14	encoding	encode	VERB
iajs-2271	125	15	this	this	DET
iajs-2271	125	16	enzyme	enzyme	NOUN
iajs-2271	125	17	in	in	ADP
iajs-2271	125	18	methanocaldococcus	methanocaldococcus	NOUN
iajs-2271	125	19	jannaschii	jannaschii	NOUN
iajs-2271	125	20	and	and	CCONJ
iajs-2271	125	21	then	then	ADV
iajs-2271	125	22	later	later	ADV
iajs-2271	125	23	the	the	DET
iajs-2271	125	24	enzyme	enzyme	NOUN
iajs-2271	125	25	was	be	AUX
iajs-2271	125	26	experimentally	experimentally	ADV
iajs-2271	125	27	verified	verify	VERB
iajs-2271	125	28	[	[	PUNCT
iajs-2271	125	29	26	26	NUM
iajs-2271	125	30	]	]	PUNCT
iajs-2271	125	31	.	.	PUNCT
iajs-2271	126	1	the	the	DET
iajs-2271	126	2	archaeal	archaeal	ADJ
iajs-2271	126	3	shikimate	shikimate	NOUN
iajs-2271	126	4	kinases	kinase	NOUN
iajs-2271	126	5	were	be	AUX
iajs-2271	126	6	found	find	VERB
iajs-2271	126	7	to	to	PART
iajs-2271	126	8	have	have	VERB
iajs-2271	126	9	no	no	DET
iajs-2271	126	10	sequence	sequence	NOUN
iajs-2271	126	11	homology	homology	NOUN
iajs-2271	126	12	to	to	ADP
iajs-2271	126	13	their	their	PRON
iajs-2271	126	14	bacterial	bacterial	ADJ
iajs-2271	126	15	counterparts	counterpart	NOUN
iajs-2271	126	16	.	.	PUNCT
iajs-2271	127	1	in	in	ADP
iajs-2271	127	2	s.	s.	PROPN
iajs-2271	127	3	solfataricus	solfataricus	PROPN
iajs-2271	127	4	,	,	PUNCT
iajs-2271	127	5	the	the	DET
iajs-2271	127	6	enzyme	enzyme	NOUN
iajs-2271	127	7	is	be	AUX
iajs-2271	127	8	not	not	PART
iajs-2271	127	9	experimentally	experimentally	ADV
iajs-2271	127	10	characterized	characterize	VERB
iajs-2271	127	11	so	so	ADV
iajs-2271	127	12	far	far	ADV
iajs-2271	127	13	.	.	PUNCT
iajs-2271	128	1	the	the	DET
iajs-2271	128	2	homology	homology	NOUN
iajs-2271	128	3	search	search	NOUN
iajs-2271	128	4	with	with	ADP
iajs-2271	128	5	the	the	DET
iajs-2271	128	6	characterized	characterize	VERB
iajs-2271	128	7	shikimate	shikimate	NOUN
iajs-2271	128	8	kinase	kinase	NOUN
iajs-2271	128	9	from	from	ADP
iajs-2271	128	10	methanocaldococcus	methanocaldococcus	NOUN
iajs-2271	128	11	jannaschii	jannaschii	PROPN
iajs-2271	128	12	against	against	ADP
iajs-2271	128	13	s.	s.	PROPN
iajs-2271	128	14	solfataricus	solfataricus	PROPN
iajs-2271	128	15	genome	genome	NOUN
iajs-2271	128	16	helped	help	VERB
iajs-2271	128	17	in	in	ADP
iajs-2271	128	18	finding	find	VERB
iajs-2271	128	19	the	the	DET
iajs-2271	128	20	candidate	candidate	NOUN
iajs-2271	128	21	gene	gene	NOUN
iajs-2271	128	22	for	for	ADP
iajs-2271	128	23	this	this	DET
iajs-2271	128	24	enzyme	enzyme	NOUN
iajs-2271	128	25	to	to	PART
iajs-2271	128	26	be	be	AUX
iajs-2271	128	27	sso0308	sso0308	ADJ
iajs-2271	128	28	(	(	PUNCT
iajs-2271	128	29	cog	cog	PROPN
iajs-2271	128	30	1685	1685	NUM
iajs-2271	128	31	)	)	PUNCT
iajs-2271	128	32	.	.	PUNCT
iajs-2271	129	1	figure	figure	NOUN
iajs-2271	129	2	1	1	NUM
iajs-2271	129	3	.	.	PUNCT
iajs-2271	130	1	a	a	DET
iajs-2271	130	2	new	new	ADJ
iajs-2271	130	3	version	version	NOUN
iajs-2271	130	4	(	(	PUNCT
iajs-2271	130	5	less	less	ADV
iajs-2271	130	6	-	-	PUNCT
iajs-2271	130	7	detailed	detail	VERB
iajs-2271	130	8	display	display	NOUN
iajs-2271	130	9	)	)	PUNCT
iajs-2271	130	10	complete	complete	ADJ
iajs-2271	130	11	super	super	ADJ
iajs-2271	130	12	pathway	pathway	NOUN
iajs-2271	130	13	of	of	ADP
iajs-2271	130	14	phenylalanine	phenylalanine	NOUN
iajs-2271	130	15	,	,	PUNCT
iajs-2271	130	16	tyrosine	tyrosine	NOUN
iajs-2271	130	17	and	and	CCONJ
iajs-2271	130	18	tryptophan	tryptophan	NOUN
iajs-2271	130	19	biosynthesis	biosynthesis	NOUN
iajs-2271	130	20	.	.	PUNCT
iajs-2271	131	1	table	table	NOUN
iajs-2271	131	2	1	1	NUM
iajs-2271	131	3	.	.	PUNCT
iajs-2271	131	4	metabolic	metabolic	NOUN
iajs-2271	131	5	holes	hole	NOUN
iajs-2271	131	6	(	(	PUNCT
iajs-2271	131	7	missing	miss	VERB
iajs-2271	131	8	enzymes	enzyme	NOUN
iajs-2271	131	9	)	)	PUNCT
iajs-2271	131	10	in	in	ADP
iajs-2271	131	11	the	the	DET
iajs-2271	131	12	predicted	predict	VERB
iajs-2271	131	13	super	super	ADJ
iajs-2271	131	14	biosynthetic	biosynthetic	ADJ
iajs-2271	131	15	pathways	pathway	NOUN
iajs-2271	131	16	of	of	ADP
iajs-2271	131	17	the	the	DET
iajs-2271	131	18	amino	amino	ADJ
iajs-2271	131	19	acids	acid	NOUN
iajs-2271	131	20	groups	group	NOUN
iajs-2271	131	21	and	and	CCONJ
iajs-2271	131	22	the	the	DET
iajs-2271	131	23	pathways	pathway	NOUN
iajs-2271	131	24	of	of	ADP
iajs-2271	131	25	the	the	DET
iajs-2271	131	26	individual	individual	ADJ
iajs-2271	131	27	amino	amino	NOUN
iajs-2271	131	28	acids	acid	NOUN
iajs-2271	131	29	in	in	ADP
iajs-2271	131	30	the	the	DET
iajs-2271	131	31	non	non	ADJ
iajs-2271	131	32	-	-	ADJ
iajs-2271	131	33	curated	curate	VERB
iajs-2271	131	34	pgdb	pgdb	NOUN
iajs-2271	131	35	of	of	ADP
iajs-2271	131	36	sulfolobus	sulfolobus	NOUN
iajs-2271	131	37	solfataricus	solfataricus	ADJ
iajs-2271	131	38	p2	p2	NOUN
iajs-2271	131	39	.	.	PUNCT
iajs-2271	132	1	aromatic	aromatic	ADJ
iajs-2271	132	2	amino	amino	NOUN
iajs-2271	132	3	acids	acid	NOUN
iajs-2271	132	4	biosynthesis	biosynthesis	NOUN
iajs-2271	132	5	(	(	PUNCT
iajs-2271	132	6	phenylalanine	phenylalanine	NOUN
iajs-2271	132	7	,	,	PUNCT
iajs-2271	132	8	tyrosine	tyrosine	NOUN
iajs-2271	132	9	and	and	CCONJ
iajs-2271	132	10	tryptophan	tryptophan	NOUN
iajs-2271	132	11	):	):	PUNCT
iajs-2271	132	12	ec	ec	PROPN
iajs-2271	132	13	2.7.1.71	2.7.1.71	NUM
iajs-2271	132	14	archaeal	archaeal	ADJ
iajs-2271	132	15	shikimate	shikimate	NOUN
iajs-2271	132	16	kinase	kinase	PROPN
iajs-2271	132	17	sso0308	sso0308	PROPN
iajs-2271	132	18	cog1685	cog1685	PROPN
iajs-2271	132	19	ec	ec	PROPN
iajs-2271	132	20	2.6.1.5	2.6.1.5	NUM
iajs-2271	132	21	(	(	PUNCT
iajs-2271	132	22	homologous	homologous	ADJ
iajs-2271	132	23	to	to	ADP
iajs-2271	132	24	ec	ec	PROPN
iajs-2271	132	25	2.6.1.1	2.6.1.1	NUM
iajs-2271	132	26	)	)	PUNCT
iajs-2271	132	27	aspartate	aspartate	NOUN
iajs-2271	132	28	aminotransferase	aminotransferase	NOUN
iajs-2271	132	29	tryptophan	tryptophan	NOUN
iajs-2271	132	30	synthase	synthase	NOUN
iajs-2271	132	31	beta	beta	NOUN
iajs-2271	132	32	chain	chain	NOUN
iajs-2271	132	33	2	2	NUM
iajs-2271	132	34	aspb-1	aspb-1	NUM
iajs-2271	132	35	aspb-2	aspb-2	ADV
iajs-2271	132	36	aspb-3	aspb-3	PRON
iajs-2271	132	37	aspb-4	aspb-4	NUM
iajs-2271	132	38	trpb	trpb	PROPN
iajs-2271	132	39	sso0104	sso0104	PROPN
iajs-2271	132	40	sso0897	sso0897	PROPN
iajs-2271	132	41	sso1177	sso1177	PROPN
iajs-2271	132	42	sso3245	sso3245	PROPN
iajs-2271	132	43	sso1145	sso1145	PROPN
iajs-2271	132	44	cog1167	cog1167	PROPN
iajs-2271	132	45	cog0436	cog0436	PROPN
iajs-2271	132	46	cog0436	cog0436	PROPN
iajs-2271	132	47	cog1167	cog1167	PROPN
iajs-2271	132	48	cog0133	cog0133	PROPN
iajs-2271	132	49	ec	ec	PROPN
iajs-2271	132	50	1.3.1.12	1.3.1.12	NUM
iajs-2271	132	51	archaeal	archaeal	ADJ
iajs-2271	132	52	prephenate	prephenate	ADJ
iajs-2271	132	53	dehydrogenase	dehydrogenase	NOUN
iajs-2271	132	54	tyra	tyra	PROPN
iajs-2271	132	55	sso0302	sso0302	PROPN
iajs-2271	132	56	cog0287	cog0287	PROPN
iajs-2271	132	57	branched	branch	VERB
iajs-2271	132	58	-	-	PUNCT
iajs-2271	132	59	chain	chain	NOUN
iajs-2271	132	60	amino	amino	NOUN
iajs-2271	132	61	acids	acid	NOUN
iajs-2271	132	62	biosynthesis	biosynthesis	NOUN
iajs-2271	132	63	(	(	PUNCT
iajs-2271	132	64	leucine	leucine	NOUN
iajs-2271	132	65	,	,	PUNCT
iajs-2271	132	66	isoleucine	isoleucine	NOUN
iajs-2271	132	67	and	and	CCONJ
iajs-2271	132	68	valine	valine	NOUN
iajs-2271	132	69	):	):	PUNCT
iajs-2271	132	70	ec	ec	PROPN
iajs-2271	132	71	2.6.1.42	2.6.1.42	NUM
iajs-2271	132	72	aspartate	aspartate	NOUN
iajs-2271	132	73	aminotransferase	aminotransferase	NOUN
iajs-2271	132	74	as	as	ADP
iajs-2271	132	75	ec	ec	PROPN
iajs-2271	132	76	2.6.1.5	2.6.1.5	NUM
iajs-2271	132	77	individual	individual	ADJ
iajs-2271	132	78	amino	amino	NOUN
iajs-2271	132	79	acids	acid	NOUN
iajs-2271	132	80	biosynthesis	biosynthesis	NOUN
iajs-2271	132	81	:	:	PUNCT
iajs-2271	132	82	methionine	methionine	NOUN
iajs-2271	132	83	:	:	PUNCT
iajs-2271	132	84	ec	ec	PROPN
iajs-2271	132	85	2.3.1.46	2.3.1.46	PROPN
iajs-2271	132	86	homoserine	homoserine	VERB
iajs-2271	132	87	o	o	NOUN
iajs-2271	132	88	-	-	NOUN
iajs-2271	132	89	succinyltransferase	succinyltransferase	NOUN
iajs-2271	132	90	?	?	PUNCT
iajs-2271	132	91	?	?	PUNCT
iajs-2271	133	1	cog1897	cog1897	PROPN
iajs-2271	133	2	7	7	NUM
iajs-2271	133	3	ibn	ibn	PROPN
iajs-2271	133	4	al	al	PROPN
iajs-2271	133	5	-	-	PUNCT
iajs-2271	133	6	haitham	haitham	PROPN
iajs-2271	133	7	jour	jour	X
iajs-2271	133	8	.	.	PROPN
iajs-2271	134	1	for	for	ADP
iajs-2271	134	2	pure	pure	ADJ
iajs-2271	134	3	&	&	CCONJ
iajs-2271	134	4	appl	appl	PROPN
iajs-2271	134	5	.	.	PUNCT
iajs-2271	135	1	sci	sci	PROPN
iajs-2271	135	2	.	.	PROPN
iajs-2271	135	3	32	32	NUM
iajs-2271	135	4	(	(	PUNCT
iajs-2271	135	5	3	3	NUM
iajs-2271	135	6	)	)	PUNCT
iajs-2271	135	7	2019	2019	NUM
iajs-2271	135	8	ec	ec	PROPN
iajs-2271	135	9	2.5.1.48	2.5.1.48	PROPN
iajs-2271	135	10	(	(	PUNCT
iajs-2271	135	11	formerly	formerly	ADV
iajs-2271	135	12	4.2.99.9	4.2.99.9	X
iajs-2271	135	13	)	)	PUNCT
iajs-2271	135	14	cystathionine	cystathionine	NOUN
iajs-2271	135	15	beta	beta	NOUN
iajs-2271	135	16	-	-	PUNCT
iajs-2271	135	17	lyase	lyase	NOUN
iajs-2271	135	18	or	or	CCONJ
iajs-2271	135	19	o	o	NOUN
iajs-2271	135	20	-	-	NOUN
iajs-2271	135	21	succinylhomoserine	succinylhomoserine	ADJ
iajs-2271	135	22	(	(	PUNCT
iajs-2271	135	23	thiol)-lyase	thiol)-lyase	PROPN
iajs-2271	135	24	(	(	PUNCT
iajs-2271	135	25	cystathionine	cystathionine	NOUN
iajs-2271	135	26	gamma	gamma	NOUN
iajs-2271	135	27	-	-	PUNCT
iajs-2271	135	28	synthase	synthase	NOUN
iajs-2271	135	29	)	)	PUNCT
iajs-2271	135	30	metb	metb	ADJ
iajs-2271	135	31	sso2368	sso2368	NOUN
iajs-2271	135	32	cog0626	cog0626	PROPN
iajs-2271	135	33	ec	ec	PROPN
iajs-2271	135	34	4.4.1.8	4.4.1.8	NUM
iajs-2271	135	35	cystathionine	cystathionine	PROPN
iajs-2271	135	36	beta	beta	NOUN
iajs-2271	135	37	-	-	PUNCT
iajs-2271	135	38	lyase	lyase	NOUN
iajs-2271	135	39	or	or	CCONJ
iajs-2271	135	40	o	o	NOUN
iajs-2271	135	41	-	-	NOUN
iajs-2271	135	42	succinylhomoserine	succinylhomoserine	ADJ
iajs-2271	135	43	(	(	PUNCT
iajs-2271	135	44	thiol)-lyase	thiol)-lyase	PROPN
iajs-2271	135	45	(	(	PUNCT
iajs-2271	135	46	cystathionine	cystathionine	NOUN
iajs-2271	135	47	gamma	gamma	NOUN
iajs-2271	135	48	-	-	PUNCT
iajs-2271	135	49	synthase	synthase	NOUN
iajs-2271	135	50	)	)	PUNCT
iajs-2271	135	51	metb	metb	ADJ
iajs-2271	135	52	sso2368	sso2368	NOUN
iajs-2271	135	53	cog0626	cog0626	PROPN
iajs-2271	135	54	ec	ec	PROPN
iajs-2271	135	55	2.1.1.13	2.1.1.13	NUM
iajs-2271	135	56	methionine	methionine	NOUN
iajs-2271	135	57	synthase	synthase	NOUN
iajs-2271	135	58	?	?	PUNCT
iajs-2271	135	59	?	?	PUNCT
iajs-2271	136	1	arginine	arginine	NOUN
iajs-2271	136	2	:	:	PUNCT
iajs-2271	136	3	ec	ec	PROPN
iajs-2271	136	4	2.3.1.1	2.3.1.1	NUM
iajs-2271	136	5	lysx	lysx	NOUN
iajs-2271	136	6	/	/	SYM
iajs-2271	136	7	glutamate	glutamate	NOUN
iajs-2271	136	8	n	n	CCONJ
iajs-2271	136	9	-	-	PUNCT
iajs-2271	136	10	acetyltransferase	acetyltransferase	ADJ
iajs-2271	136	11	lysx	lysx	NOUN
iajs-2271	136	12	/rimk-1	/rimk-1	PROPN
iajs-2271	136	13	sso0159	sso0159	NOUN
iajs-2271	137	1	cog0189	cog0189	NOUN
iajs-2271	137	2	ec	ec	PROPN
iajs-2271	137	3	2.6.1.13	2.6.1.13	PROPN
iajs-2271	137	4	acetylornithine	acetylornithine	NOUN
iajs-2271	137	5	/	/	SYM
iajs-2271	137	6	acetyl	acetyl	NOUN
iajs-2271	137	7	lysine	lysine	NOUN
iajs-2271	137	8	aminotransferase(argd	aminotransferase(argd	PROPN
iajs-2271	137	9	/	/	SYM
iajs-2271	137	10	lysj	lysj	NOUN
iajs-2271	137	11	)	)	PUNCT
iajs-2271	137	12	argd	argd	PROPN
iajs-2271	137	13	/	/	SYM
iajs-2271	137	14	lysj	lysj	PROPN
iajs-2271	137	15	sso0160	sso0160	PROPN
iajs-2271	137	16	cog4992	cog4992	PROPN
iajs-2271	137	17	alanine	alanine	NOUN
iajs-2271	137	18	:	:	PUNCT
iajs-2271	137	19	three	three	NUM
iajs-2271	137	20	pathway	pathway	NOUN
iajs-2271	137	21	variations	variation	NOUN
iajs-2271	137	22	were	be	AUX
iajs-2271	137	23	created	create	VERB
iajs-2271	137	24	(	(	PUNCT
iajs-2271	137	25	i	i	PROPN
iajs-2271	137	26	,	,	PUNCT
iajs-2271	137	27	ii	ii	PROPN
iajs-2271	137	28	and	and	CCONJ
iajs-2271	137	29	iii	iii	X
iajs-2271	137	30	)	)	PUNCT
iajs-2271	137	31	ec	ec	PROPN
iajs-2271	137	32	2.6.1.66	2.6.1.66	NUM
iajs-2271	137	33	valine	valine	NOUN
iajs-2271	137	34	-	-	PUNCT
iajs-2271	137	35	pyruvate	pyruvate	NOUN
iajs-2271	137	36	transaminase	transaminase	NOUN
iajs-2271	137	37	aspb-1	aspb-1	PROPN
iajs-2271	137	38	sso0104	sso0104	NOUN
iajs-2271	137	39	cog1167	cog1167	ADJ
iajs-2271	137	40	ec	ec	PROPN
iajs-2271	137	41	2.6.1.2	2.6.1.2	NUM
iajs-2271	137	42	alanine	alanine	NOUN
iajs-2271	137	43	aminotransferase	aminotransferase	NOUN
iajs-2271	137	44	(	(	PUNCT
iajs-2271	137	45	alanine	alanine	NOUN
iajs-2271	137	46	aminotransaminase	aminotransaminase	NOUN
iajs-2271	137	47	)	)	PUNCT
iajs-2271	138	1	aspb-2	aspb-2	PROPN
iajs-2271	138	2	sso0897	sso0897	PROPN
iajs-2271	138	3	cog0436	cog0436	PROPN
iajs-2271	138	4	cysteine	cysteine	PROPN
iajs-2271	138	5	:	:	PUNCT
iajs-2271	138	6	ec	ec	PROPN
iajs-2271	138	7	2.3.1.30	2.3.1.30	PROPN
iajs-2271	138	8	serine	serine	NOUN
iajs-2271	138	9	o	o	NOUN
iajs-2271	138	10	-	-	NOUN
iajs-2271	138	11	acetyltransferase	acetyltransferase	ADJ
iajs-2271	138	12	(	(	PUNCT
iajs-2271	138	13	cyse	cyse	NOUN
iajs-2271	138	14	)	)	PUNCT
iajs-2271	138	15	cyse	cyse	NOUN
iajs-2271	138	16	sso0372	sso0372	VERB
iajs-2271	138	17	cog1045	cog1045	NOUN
iajs-2271	138	18	serine	serine	NOUN
iajs-2271	138	19	:	:	PUNCT
iajs-2271	138	20	ec	ec	PROPN
iajs-2271	138	21	2.6.1.52	2.6.1.52	NUM
iajs-2271	138	22	phosphoserine	phosphoserine	NOUN
iajs-2271	138	23	transaminase	transaminase	NOUN
iajs-2271	138	24	/	/	SYM
iajs-2271	138	25	serine	serine	NOUN
iajs-2271	138	26	-	-	PUNCT
iajs-2271	138	27	pyruvate	pyruvate	NOUN
iajs-2271	138	28	aminotransferase	aminotransferase	NOUN
iajs-2271	138	29	(	(	PUNCT
iajs-2271	138	30	agxt	agxt	ADV
iajs-2271	138	31	)	)	PUNCT
iajs-2271	138	32	agxt	agxt	ADP
iajs-2271	138	33	sso2597	sso2597	NOUN
iajs-2271	138	34	cog0075	cog0075	PROPN
iajs-2271	138	35	ec	ec	PROPN
iajs-2271	138	36	3.1.3.3	3.1.3.3	NUM
iajs-2271	138	37	phosphoserine	phosphoserine	NOUN
iajs-2271	138	38	phosphatase	phosphatase	NOUN
iajs-2271	138	39	(	(	PUNCT
iajs-2271	138	40	psp	psp	NOUN
iajs-2271	138	41	)	)	PUNCT
iajs-2271	138	42	sso0094	sso0094	NOUN
iajs-2271	138	43	cog0560	cog0560	ADJ
iajs-2271	138	44	glycine	glycine	NOUN
iajs-2271	138	45	:	:	PUNCT
iajs-2271	138	46	ec	ec	PROPN
iajs-2271	138	47	3.1.3.18	3.1.3.18	NUM
iajs-2271	138	48	phosphoglycolate	phosphoglycolate	NOUN
iajs-2271	138	49	phosphatase	phosphatase	NOUN
iajs-2271	138	50	1	1	NUM
iajs-2271	138	51	(	(	PUNCT
iajs-2271	138	52	pgp	pgp	NOUN
iajs-2271	138	53	1	1	NUM
iajs-2271	138	54	)	)	PUNCT
iajs-2271	138	55	phosphoglycolate	phosphoglycolate	NOUN
iajs-2271	138	56	phosphatase	phosphatase	NOUN
iajs-2271	138	57	2	2	NUM
iajs-2271	138	58	(	(	PUNCT
iajs-2271	138	59	pgp	pgp	NOUN
iajs-2271	138	60	2	2	NUM
iajs-2271	138	61	)	)	PUNCT
iajs-2271	138	62	sso0094	sso0094	NOUN
iajs-2271	138	63	sso2157	sso2157	PROPN
iajs-2271	138	64	cog0561	cog0561	PROPN
iajs-2271	138	65	cog0561	cog0561	PROPN
iajs-2271	138	66	ec	ec	PROPN
iajs-2271	138	67	1.1.99.14	1.1.99.14	NUM
iajs-2271	138	68	replaced	replace	VERB
iajs-2271	138	69	by	by	ADP
iajs-2271	138	70	ec	ec	PROPN
iajs-2271	138	71	1.1.1.26	1.1.1.26	PROPN
iajs-2271	138	72	glycolate	glycolate	NOUN
iajs-2271	138	73	reductase	reductase	NOUN
iajs-2271	138	74	/	/	SYM
iajs-2271	138	75	d-3	d-3	ADJ
iajs-2271	138	76	-	-	PUNCT
iajs-2271	138	77	phosphoglycerate	phosphoglycerate	NOUN
iajs-2271	138	78	dehydrogenase	dehydrogenase	NOUN
iajs-2271	138	79	(	(	PUNCT
iajs-2271	138	80	sera-1	sera-1	NUM
iajs-2271	138	81	)	)	PUNCT
iajs-2271	138	82	sera-1	sera-1	NUM
iajs-2271	138	83	sso0905	sso0905	VERB
iajs-2271	138	84	cog0111	cog0111	NOUN
iajs-2271	138	85	ec	ec	PROPN
iajs-2271	138	86	2.6.1.4	2.6.1.4	NUM
iajs-2271	138	87	glycine	glycine	NOUN
iajs-2271	138	88	transaminase	transaminase	NOUN
iajs-2271	138	89	/aspartate	/aspartate	NOUN
iajs-2271	138	90	aminotransferase	aminotransferase	PROPN
iajs-2271	138	91	(	(	PUNCT
iajs-2271	138	92	ec	ec	PROPN
iajs-2271	138	93	2.6.1.1	2.6.1.1	NUM
iajs-2271	138	94	)	)	PUNCT
iajs-2271	138	95	aspb-2	aspb-2	PRON
iajs-2271	138	96	sso0897	sso0897	VERB
iajs-2271	138	97	cog0436	cog0436	PROPN
iajs-2271	138	98	glutamate	glutamate	NOUN
iajs-2271	138	99	:	:	PUNCT
iajs-2271	139	1	ec	ec	PROPN
iajs-2271	139	2	1.4.1.4	1.4.1.4	NUM
iajs-2271	139	3	nad	nad	ADJ
iajs-2271	139	4	specific	specific	ADJ
iajs-2271	139	5	glutamate	glutamate	NOUN
iajs-2271	139	6	dehydrogenase	dehydrogenase	NOUN
iajs-2271	139	7	(	(	PUNCT
iajs-2271	139	8	gdha-1	gdha-1	NOUN
iajs-2271	139	9	)	)	PUNCT
iajs-2271	139	10	(	(	PUNCT
iajs-2271	139	11	gdha-2	gdha-2	PROPN
iajs-2271	139	12	)	)	PUNCT
iajs-2271	139	13	(	(	PUNCT
iajs-2271	139	14	gdha-3	gdha-3	PROPN
iajs-2271	139	15	)	)	PUNCT
iajs-2271	139	16	(	(	PUNCT
iajs-2271	139	17	gdha-4	gdha-4	NOUN
iajs-2271	139	18	)	)	PUNCT
iajs-2271	139	19	gdha-1	gdha-1	NUM
iajs-2271	139	20	gdha-2	gdha-2	PROPN
iajs-2271	139	21	gdha-3	gdha-3	PROPN
iajs-2271	139	22	gdha-4	gdha-4	NUM
iajs-2271	139	23	sso1457	sso1457	NOUN
iajs-2271	139	24	sso1907	sso1907	NOUN
iajs-2271	139	25	sso1930	sso1930	PROPN
iajs-2271	139	26	sso2044	sso2044	PROPN
iajs-2271	139	27	cog0334	cog0334	PROPN
iajs-2271	139	28	cog0334	cog0334	PROPN
iajs-2271	139	29	cog0334	cog0334	PROPN
iajs-2271	139	30	cog0334	cog0334	NOUN
iajs-2271	139	31	proline	proline	NOUN
iajs-2271	139	32	:	:	PUNCT
iajs-2271	139	33	unknown	unknown	ADJ
iajs-2271	139	34	ec	ec	PROPN
iajs-2271	139	35	:	:	PUNCT
iajs-2271	139	36	found	find	VERB
iajs-2271	139	37	to	to	PART
iajs-2271	139	38	be	be	AUX
iajs-2271	139	39	ec	ec	PROPN
iajs-2271	139	40	1.2.1.41	1.2.1.41	NUM
iajs-2271	139	41	aldehyde	aldehyde	NOUN
iajs-2271	139	42	dehydrogenase	dehydrogenase	NOUN
iajs-2271	139	43	(	(	PUNCT
iajs-2271	139	44	aldht	aldht	NOUN
iajs-2271	139	45	)	)	PUNCT
iajs-2271	139	46	glutamate-5	glutamate-5	PROPN
iajs-2271	139	47	-	-	PUNCT
iajs-2271	139	48	semialdehyde	semialdehyde	NOUN
iajs-2271	139	49	dehydrogenase	dehydrogenase	NOUN
iajs-2271	139	50	aldht	aldht	NOUN
iajs-2271	139	51	?	?	PUNCT
iajs-2271	139	52	sso3117	sso3117	VERB
iajs-2271	139	53	?	?	PUNCT
iajs-2271	140	1	cog0014	cog0014	NOUN
iajs-2271	140	2	?	?	PUNCT
iajs-2271	141	1	histidine	histidine	NOUN
iajs-2271	141	2	:	:	PUNCT
iajs-2271	141	3	ec	ec	PROPN
iajs-2271	141	4	3.6.1.31	3.6.1.31	NUM
iajs-2271	141	5	phosphoribosyl	phosphoribosyl	PROPN
iajs-2271	141	6	-	-	PUNCT
iajs-2271	141	7	atp	atp	PROPN
iajs-2271	141	8	pyrophosphatase	pyrophosphatase	NOUN
iajs-2271	141	9	hise	hise	PROPN
iajs-2271	141	10	sso6223	sso6223	PROPN
iajs-2271	141	11	cog0140	cog0140	PROPN
iajs-2271	141	12	ec	ec	PROPN
iajs-2271	141	13	3.1.3.15	3.1.3.15	NUM
iajs-2271	141	14	histidinol	histidinol	ADJ
iajs-2271	141	15	-	-	PUNCT
iajs-2271	141	16	phosphatase	phosphatase	NOUN
iajs-2271	141	17	?	?	PUNCT
iajs-2271	142	1	c0849	c0849	ADJ
iajs-2271	142	2	?	?	NOUN
iajs-2271	142	3	cog1387	cog1387	ADJ
iajs-2271	142	4	lysine	lysine	NOUN
iajs-2271	142	5	:	:	PUNCT
iajs-2271	142	6	alpha	alpha	NOUN
iajs-2271	142	7	-	-	PUNCT
iajs-2271	142	8	aminoadipic	aminoadipic	ADJ
iajs-2271	142	9	acid	acid	NOUN
iajs-2271	142	10	(	(	PUNCT
iajs-2271	142	11	aaa	aaa	NOUN
iajs-2271	142	12	)	)	PUNCT
iajs-2271	142	13	pathway	pathway	NOUN
iajs-2271	142	14	was	be	AUX
iajs-2271	142	15	completely	completely	ADV
iajs-2271	142	16	created	create	VERB
iajs-2271	142	17	in	in	ADP
iajs-2271	142	18	sulfolobus	sulfolobus	ADJ
iajs-2271	142	19	solfataricus	solfataricus	ADJ
iajs-2271	142	20	pgdb	pgdb	NOUN
iajs-2271	142	21	the	the	DET
iajs-2271	142	22	chorismate	chorismate	NOUN
iajs-2271	142	23	pathway	pathway	NOUN
iajs-2271	142	24	was	be	AUX
iajs-2271	142	25	curated	curate	VERB
iajs-2271	142	26	by	by	ADP
iajs-2271	142	27	adding	add	VERB
iajs-2271	142	28	the	the	DET
iajs-2271	142	29	gene	gene	NOUN
iajs-2271	142	30	and	and	CCONJ
iajs-2271	142	31	its	its	PRON
iajs-2271	142	32	product	product	NOUN
iajs-2271	142	33	to	to	ADP
iajs-2271	142	34	the	the	DET
iajs-2271	142	35	corresponding	correspond	VERB
iajs-2271	142	36	ec	ec	PROPN
iajs-2271	142	37	number	number	NOUN
iajs-2271	142	38	figure	figure	NOUN
iajs-2271	142	39	2	2	NUM
iajs-2271	142	40	.	.	NOUN
iajs-2271	142	41	8	8	NUM
iajs-2271	142	42	ibn	ibn	PROPN
iajs-2271	142	43	al	al	PROPN
iajs-2271	142	44	-	-	PUNCT
iajs-2271	142	45	haitham	haitham	PROPN
iajs-2271	142	46	jour	jour	X
iajs-2271	142	47	.	.	PROPN
iajs-2271	143	1	for	for	ADP
iajs-2271	143	2	pure	pure	ADJ
iajs-2271	143	3	&	&	CCONJ
iajs-2271	143	4	appl	appl	PROPN
iajs-2271	143	5	.	.	PUNCT
iajs-2271	144	1	sci	sci	PROPN
iajs-2271	144	2	.	.	PROPN
iajs-2271	144	3	32	32	NUM
iajs-2271	144	4	(	(	PUNCT
iajs-2271	144	5	3	3	NUM
iajs-2271	144	6	)	)	PUNCT
iajs-2271	144	7	2019	2019	NUM
iajs-2271	144	8	figure	figure	NOUN
iajs-2271	144	9	2	2	NUM
iajs-2271	144	10	.	.	NUM
iajs-2271	144	11	curated	curate	VERB
iajs-2271	144	12	chorismate	chorismate	NOUN
iajs-2271	144	13	biosynthesis	biosynthesis	NOUN
iajs-2271	144	14	.	.	PUNCT
iajs-2271	145	1	the	the	DET
iajs-2271	145	2	last	last	ADJ
iajs-2271	145	3	step	step	NOUN
iajs-2271	145	4	in	in	ADP
iajs-2271	145	5	the	the	DET
iajs-2271	145	6	phenylalanine	phenylalanine	NOUN
iajs-2271	145	7	and	and	CCONJ
iajs-2271	145	8	tyrosine	tyrosine	NOUN
iajs-2271	145	9	synthetic	synthetic	ADJ
iajs-2271	145	10	pathways	pathway	NOUN
iajs-2271	145	11	in	in	ADP
iajs-2271	145	12	eukarya	eukarya	NOUN
iajs-2271	145	13	and	and	CCONJ
iajs-2271	145	14	bacrteria	bacrteria	PROPN
iajs-2271	145	15	is	be	AUX
iajs-2271	145	16	catalyzed	catalyze	VERB
iajs-2271	145	17	by	by	ADP
iajs-2271	145	18	tyrosine	tyrosine	NOUN
iajs-2271	145	19	aminotransferase	aminotransferase	PROPN
iajs-2271	145	20	(	(	PUNCT
iajs-2271	145	21	known	know	VERB
iajs-2271	145	22	also	also	ADV
iajs-2271	145	23	as	as	ADP
iajs-2271	145	24	phenylalanine	phenylalanine	NOUN
iajs-2271	145	25	aminotransferase	aminotransferase	NOUN
iajs-2271	145	26	and	and	CCONJ
iajs-2271	145	27	also	also	ADV
iajs-2271	145	28	as	as	ADP
iajs-2271	145	29	l	l	NOUN
iajs-2271	145	30	-	-	ADJ
iajs-2271	145	31	tyrosine	tyrosine	ADJ
iajs-2271	145	32	aminotransferase	aminotransferase	NOUN
iajs-2271	145	33	(	(	PUNCT
iajs-2271	145	34	ec	ec	PROPN
iajs-2271	145	35	2.6.1.5	2.6.1.5	NUM
iajs-2271	145	36	)	)	PUNCT
iajs-2271	145	37	)	)	PUNCT
iajs-2271	145	38	.	.	PUNCT
iajs-2271	146	1	the	the	DET
iajs-2271	146	2	enzyme	enzyme	NOUN
iajs-2271	146	3	is	be	AUX
iajs-2271	146	4	not	not	PART
iajs-2271	146	5	identified	identify	VERB
iajs-2271	146	6	in	in	ADP
iajs-2271	146	7	s.	s.	PROPN
iajs-2271	146	8	solfataricus	solfataricus	PROPN
iajs-2271	146	9	,	,	PUNCT
iajs-2271	146	10	but	but	CCONJ
iajs-2271	146	11	the	the	DET
iajs-2271	146	12	pathologic	pathologic	NOUN
iajs-2271	146	13	suggested	suggest	VERB
iajs-2271	146	14	the	the	DET
iajs-2271	146	15	reaction	reaction	NOUN
iajs-2271	146	16	for	for	ADP
iajs-2271	146	17	both	both	DET
iajs-2271	146	18	final	final	ADJ
iajs-2271	146	19	steps	step	NOUN
iajs-2271	146	20	in	in	ADP
iajs-2271	146	21	tyrosine	tyrosine	NOUN
iajs-2271	146	22	and	and	CCONJ
iajs-2271	146	23	phenylalanine	phenylalanine	ADJ
iajs-2271	146	24	pathways	pathway	NOUN
iajs-2271	146	25	.	.	PUNCT
iajs-2271	147	1	in	in	ADP
iajs-2271	147	2	order	order	NOUN
iajs-2271	147	3	to	to	PART
iajs-2271	147	4	detect	detect	VERB
iajs-2271	147	5	the	the	DET
iajs-2271	147	6	candidate	candidate	NOUN
iajs-2271	147	7	gene	gene	NOUN
iajs-2271	147	8	that	that	PRON
iajs-2271	147	9	encodes	encode	VERB
iajs-2271	147	10	this	this	DET
iajs-2271	147	11	enzyme	enzyme	NOUN
iajs-2271	147	12	in	in	ADP
iajs-2271	147	13	s.	s.	PROPN
iajs-2271	147	14	solfataricus	solfataricus	PROPN
iajs-2271	147	15	,	,	PUNCT
iajs-2271	147	16	the	the	DET
iajs-2271	147	17	results	result	NOUN
iajs-2271	147	18	of	of	ADP
iajs-2271	147	19	[	[	X
iajs-2271	147	20	27	27	NUM
iajs-2271	147	21	]	]	PUNCT
iajs-2271	147	22	.	.	PUNCT
iajs-2271	148	1	were	be	AUX
iajs-2271	148	2	taken	take	VERB
iajs-2271	148	3	in	in	ADP
iajs-2271	148	4	consideration	consideration	NOUN
iajs-2271	148	5	.	.	PUNCT
iajs-2271	149	1	they	they	PRON
iajs-2271	149	2	showed	show	VERB
iajs-2271	149	3	besides	besides	SCONJ
iajs-2271	149	4	the	the	DET
iajs-2271	149	5	broad	broad	ADJ
iajs-2271	149	6	specificity	specificity	NOUN
iajs-2271	149	7	of	of	ADP
iajs-2271	149	8	aspartate	aspartate	NOUN
iajs-2271	149	9	aminotransferase	aminotransferase	NOUN
iajs-2271	149	10	in	in	ADP
iajs-2271	149	11	an	an	DET
iajs-2271	149	12	related	related	ADJ
iajs-2271	149	13	archaea	archaea	NOUN
iajs-2271	149	14	(	(	PUNCT
iajs-2271	149	15	pyrococcus	pyrococcus	ADJ
iajs-2271	149	16	furiosus	furiosus	PROPN
iajs-2271	149	17	)	)	PUNCT
iajs-2271	149	18	,	,	PUNCT
iajs-2271	149	19	that	that	SCONJ
iajs-2271	149	20	the	the	DET
iajs-2271	149	21	gene	gene	NOUN
iajs-2271	149	22	encoding	encode	VERB
iajs-2271	149	23	the	the	DET
iajs-2271	149	24	enzyme	enzyme	NOUN
iajs-2271	149	25	was	be	AUX
iajs-2271	149	26	expressed	express	VERB
iajs-2271	149	27	as	as	ADP
iajs-2271	149	28	a	a	DET
iajs-2271	149	29	polycistronic	polycistronic	ADJ
iajs-2271	149	30	message	message	NOUN
iajs-2271	149	31	as	as	ADP
iajs-2271	149	32	part	part	NOUN
iajs-2271	149	33	of	of	ADP
iajs-2271	149	34	the	the	DET
iajs-2271	149	35	aro	aro	NOUN
iajs-2271	149	36	operon	operon	PROPN
iajs-2271	149	37	,	,	PUNCT
iajs-2271	149	38	in	in	ADP
iajs-2271	149	39	which	which	PRON
iajs-2271	149	40	genes	gene	NOUN
iajs-2271	149	41	of	of	ADP
iajs-2271	149	42	aromatic	aromatic	ADJ
iajs-2271	149	43	amino	amino	NOUN
iajs-2271	149	44	acids	acid	NOUN
iajs-2271	149	45	pathways	pathway	NOUN
iajs-2271	149	46	are	be	AUX
iajs-2271	149	47	clustered	cluster	VERB
iajs-2271	149	48	close	close	ADV
iajs-2271	149	49	to	to	ADP
iajs-2271	149	50	the	the	DET
iajs-2271	149	51	other	other	ADJ
iajs-2271	149	52	aromatic	aromatic	ADJ
iajs-2271	149	53	gene	gene	NOUN
iajs-2271	149	54	cluster	cluster	NOUN
iajs-2271	149	55	(	(	PUNCT
iajs-2271	149	56	trp	trp	PROPN
iajs-2271	149	57	operon	operon	PROPN
iajs-2271	149	58	)	)	PUNCT
iajs-2271	149	59	.	.	PUNCT
iajs-2271	150	1	the	the	DET
iajs-2271	150	2	homology	homology	NOUN
iajs-2271	150	3	search	search	NOUN
iajs-2271	150	4	for	for	ADP
iajs-2271	150	5	tyrosine	tyrosine	NOUN
iajs-2271	150	6	aminotransferase	aminotransferase	PROPN
iajs-2271	150	7	in	in	ADP
iajs-2271	150	8	s.	s.	PROPN
iajs-2271	150	9	solfataricus	solfataricus	PROPN
iajs-2271	150	10	p2	p2	PROPN
iajs-2271	150	11	genome	genome	NOUN
iajs-2271	150	12	identified	identify	VERB
iajs-2271	150	13	aspartate	aspartate	NOUN
iajs-2271	150	14	aminotransferase	aminotransferase	NOUN
iajs-2271	150	15	as	as	ADP
iajs-2271	150	16	the	the	DET
iajs-2271	150	17	candidate	candidate	NOUN
iajs-2271	150	18	to	to	PART
iajs-2271	150	19	fill	fill	VERB
iajs-2271	150	20	in	in	ADP
iajs-2271	150	21	the	the	DET
iajs-2271	150	22	gap	gap	NOUN
iajs-2271	150	23	in	in	ADP
iajs-2271	150	24	the	the	DET
iajs-2271	150	25	reaction	reaction	NOUN
iajs-2271	150	26	with	with	ADP
iajs-2271	150	27	the	the	DET
iajs-2271	150	28	corresponding	correspond	VERB
iajs-2271	150	29	ec	ec	PROPN
iajs-2271	150	30	2.6.1.5	2.6.1.5	NUM
iajs-2271	150	31	figure	figure	NOUN
iajs-2271	150	32	3	3	NUM
iajs-2271	150	33	.	.	PUNCT
iajs-2271	151	1	the	the	DET
iajs-2271	151	2	gene	gene	NOUN
iajs-2271	151	3	coding	code	VERB
iajs-2271	151	4	for	for	ADP
iajs-2271	151	5	aspartate	aspartate	NOUN
iajs-2271	151	6	aminotransferase	aminotransferase	NOUN
iajs-2271	151	7	(	(	PUNCT
iajs-2271	151	8	ec	ec	PROPN
iajs-2271	151	9	2.6.1.1	2.6.1.1	NUM
iajs-2271	151	10	)	)	PUNCT
iajs-2271	151	11	was	be	AUX
iajs-2271	151	12	already	already	ADV
iajs-2271	151	13	cloned	clone	VERB
iajs-2271	151	14	and	and	CCONJ
iajs-2271	151	15	characterized	characterize	VERB
iajs-2271	151	16	in	in	ADP
iajs-2271	151	17	s.	s.	PROPN
iajs-2271	151	18	solfataricus	solfataricus	PROPN
iajs-2271	152	1	[	[	X
iajs-2271	152	2	28	28	NUM
iajs-2271	152	3	]	]	PUNCT
iajs-2271	152	4	.	.	PUNCT
iajs-2271	153	1	and	and	CCONJ
iajs-2271	153	2	was	be	AUX
iajs-2271	153	3	found	find	VERB
iajs-2271	153	4	to	to	PART
iajs-2271	153	5	be	be	AUX
iajs-2271	153	6	homologous	homologous	ADJ
iajs-2271	153	7	to	to	ADP
iajs-2271	153	8	tyrosine	tyrosine	NOUN
iajs-2271	153	9	aminotransferase	aminotransferase	PROPN
iajs-2271	153	10	(	(	PUNCT
iajs-2271	153	11	ec	ec	PROPN
iajs-2271	153	12	2.6.1.5	2.6.1.5	NUM
iajs-2271	153	13	)	)	PUNCT
iajs-2271	153	14	.	.	PUNCT
iajs-2271	154	1	the	the	DET
iajs-2271	154	2	other	other	ADJ
iajs-2271	154	3	homologous	homologous	ADJ
iajs-2271	154	4	genes	gene	NOUN
iajs-2271	154	5	were	be	AUX
iajs-2271	154	6	also	also	ADV
iajs-2271	154	7	listed	list	VERB
iajs-2271	154	8	table	table	NOUN
iajs-2271	154	9	1	1	NUM
iajs-2271	154	10	.	.	PUNCT
iajs-2271	155	1	by	by	ADP
iajs-2271	155	2	homology	homology	NOUN
iajs-2271	155	3	search	search	NOUN
iajs-2271	155	4	for	for	ADP
iajs-2271	155	5	an	an	DET
iajs-2271	155	6	archaeal	archaeal	ADJ
iajs-2271	155	7	prephenate	prephenate	ADJ
iajs-2271	155	8	dehydrogenase	dehydrogenase	NOUN
iajs-2271	155	9	(	(	PUNCT
iajs-2271	155	10	from	from	ADP
iajs-2271	155	11	pyrococcus	pyrococcus	PROPN
iajs-2271	155	12	furiosus	furiosus	PROPN
iajs-2271	155	13	dsm	dsm	PROPN
iajs-2271	155	14	3638	3638	NUM
iajs-2271	155	15	)	)	PUNCT
iajs-2271	155	16	in	in	ADP
iajs-2271	155	17	the	the	DET
iajs-2271	155	18	s.	s.	PROPN
iajs-2271	155	19	solfataricus	solfataricus	PROPN
iajs-2271	155	20	p2	p2	PROPN
iajs-2271	155	21	genome	genome	NOUN
iajs-2271	155	22	,	,	PUNCT
iajs-2271	155	23	the	the	DET
iajs-2271	155	24	candidate	candidate	NOUN
iajs-2271	155	25	gene	gene	NOUN
iajs-2271	155	26	encoding	encode	VERB
iajs-2271	155	27	this	this	DET
iajs-2271	155	28	enzyme	enzyme	NOUN
iajs-2271	155	29	was	be	AUX
iajs-2271	155	30	identified	identify	VERB
iajs-2271	155	31	to	to	PART
iajs-2271	155	32	be	be	AUX
iajs-2271	155	33	tyra	tyra	PROPN
iajs-2271	155	34	(	(	PUNCT
iajs-2271	155	35	sso0302	sso0302	NOUN
iajs-2271	155	36	)	)	PUNCT
iajs-2271	155	37	in	in	ADP
iajs-2271	155	38	s.	s.	PROPN
iajs-2271	155	39	solfataricus	solfataricus	PROPN
iajs-2271	155	40	p2	p2	PROPN
iajs-2271	155	41	(	(	PUNCT
iajs-2271	155	42	cog0287	cog0287	NOUN
iajs-2271	155	43	and	and	CCONJ
iajs-2271	155	44	cog1605	cog1605	NOUN
iajs-2271	155	45	)	)	PUNCT
iajs-2271	155	46	.	.	PUNCT
iajs-2271	156	1	in	in	ADP
iajs-2271	156	2	different	different	ADJ
iajs-2271	156	3	databases	database	NOUN
iajs-2271	156	4	such	such	ADJ
iajs-2271	156	5	as	as	ADP
iajs-2271	156	6	brenda	brenda	NOUN
iajs-2271	156	7	,	,	PUNCT
iajs-2271	156	8	kegg	kegg	NOUN
iajs-2271	156	9	and	and	CCONJ
iajs-2271	156	10	nicezyme	nicezyme	PROPN
iajs-2271	156	11	,	,	PUNCT
iajs-2271	156	12	this	this	DET
iajs-2271	156	13	enzyme	enzyme	NOUN
iajs-2271	156	14	especially	especially	ADV
iajs-2271	156	15	in	in	ADP
iajs-2271	156	16	the	the	DET
iajs-2271	156	17	enteric	enteric	ADJ
iajs-2271	156	18	bacteria	bacteria	NOUN
iajs-2271	156	19	possesses	possess	VERB
iajs-2271	156	20	ec	ec	PROPN
iajs-2271	156	21	5.4.99.5	5.4.99.5	NUM
iajs-2271	156	22	activity	activity	NOUN
iajs-2271	156	23	and	and	CCONJ
iajs-2271	156	24	converts	convert	NOUN
iajs-2271	156	25	chorismate	chorismate	VERB
iajs-2271	156	26	into	into	ADP
iajs-2271	156	27	prephenate	prephenate	ADJ
iajs-2271	156	28	just	just	ADV
iajs-2271	156	29	a	a	DET
iajs-2271	156	30	step	step	NOUN
iajs-2271	156	31	before	before	ADP
iajs-2271	156	32	the	the	DET
iajs-2271	156	33	reaction	reaction	NOUN
iajs-2271	156	34	(	(	PUNCT
iajs-2271	156	35	ec	ec	PROPN
iajs-2271	156	36	1.3.1.12	1.3.1.12	NUM
iajs-2271	156	37	)	)	PUNCT
iajs-2271	156	38	catalyzed	catalyze	VERB
iajs-2271	156	39	by	by	ADP
iajs-2271	156	40	this	this	DET
iajs-2271	156	41	enzyme	enzyme	NOUN
iajs-2271	156	42	in	in	ADP
iajs-2271	156	43	tyrosine	tyrosine	NOUN
iajs-2271	156	44	biosynthesis	biosynthesis	NOUN
iajs-2271	156	45	pathway	pathway	NOUN
iajs-2271	156	46	[	[	X
iajs-2271	156	47	29	29	NUM
iajs-2271	156	48	]	]	PUNCT
iajs-2271	156	49	.	.	PUNCT
iajs-2271	157	1	figure	figure	VERB
iajs-2271	157	2	3	3	NUM
iajs-2271	157	3	.	.	X
iajs-2271	157	4	3.2.2	3.2.2	NUM
iajs-2271	157	5	.	.	PUNCT
iajs-2271	157	6	branched	branch	VERB
iajs-2271	157	7	-	-	PUNCT
iajs-2271	157	8	chain	chain	NOUN
iajs-2271	157	9	amino	amino	NOUN
iajs-2271	157	10	acid	acid	NOUN
iajs-2271	157	11	biosynthetic	biosynthetic	ADJ
iajs-2271	157	12	pathways	pathway	NOUN
iajs-2271	157	13	(	(	PUNCT
iajs-2271	157	14	leucine	leucine	NOUN
iajs-2271	157	15	,	,	PUNCT
iajs-2271	157	16	isoleucine	isoleucine	NOUN
iajs-2271	157	17	and	and	CCONJ
iajs-2271	157	18	valine	valine	NOUN
iajs-2271	157	19	)	)	PUNCT
iajs-2271	157	20	the	the	DET
iajs-2271	157	21	final	final	ADJ
iajs-2271	157	22	step	step	NOUN
iajs-2271	157	23	in	in	ADP
iajs-2271	157	24	leucine	leucine	NOUN
iajs-2271	157	25	,	,	PUNCT
iajs-2271	157	26	isoleucine	isoleucine	NOUN
iajs-2271	157	27	and	and	CCONJ
iajs-2271	157	28	valine	valine	NOUN
iajs-2271	157	29	biosynthesis	biosynthesis	NOUN
iajs-2271	157	30	is	be	AUX
iajs-2271	157	31	catalyzed	catalyze	VERB
iajs-2271	157	32	by	by	ADP
iajs-2271	157	33	the	the	DET
iajs-2271	157	34	enzyme	enzyme	NOUN
iajs-2271	157	35	branched	branch	VERB
iajs-2271	157	36	-	-	PUNCT
iajs-2271	157	37	chain	chain	NOUN
iajs-2271	157	38	aminotransferase	aminotransferase	NOUN
iajs-2271	157	39	(	(	PUNCT
iajs-2271	157	40	bcat	bcat	PROPN
iajs-2271	157	41	,	,	PUNCT
iajs-2271	157	42	ec	ec	PROPN
iajs-2271	157	43	2.6.1.42	2.6.1.42	NUM
iajs-2271	157	44	)	)	PUNCT
iajs-2271	157	45	,	,	PUNCT
iajs-2271	157	46	which	which	PRON
iajs-2271	157	47	is	be	AUX
iajs-2271	157	48	specified	specify	VERB
iajs-2271	157	49	as	as	ADP
iajs-2271	157	50	ilve	ilve	NOUN
iajs-2271	157	51	.	.	PUNCT
iajs-2271	158	1	the	the	DET
iajs-2271	158	2	enzyme	enzyme	NOUN
iajs-2271	158	3	and	and	CCONJ
iajs-2271	158	4	its	its	PRON
iajs-2271	158	5	coding	code	VERB
iajs-2271	158	6	gene	gene	NOUN
iajs-2271	158	7	are	be	AUX
iajs-2271	158	8	not	not	PART
iajs-2271	158	9	characterized	characterize	VERB
iajs-2271	158	10	in	in	ADP
iajs-2271	158	11	s.	s.	PROPN
iajs-2271	158	12	solfataricus	solfataricus	PROPN
iajs-2271	158	13	due	due	ADP
iajs-2271	158	14	to	to	ADP
iajs-2271	158	15	lack	lack	NOUN
iajs-2271	158	16	of	of	ADP
iajs-2271	158	17	homology	homology	NOUN
iajs-2271	158	18	9	9	NUM
iajs-2271	158	19	ibn	ibn	PROPN
iajs-2271	158	20	al	al	PROPN
iajs-2271	158	21	-	-	PUNCT
iajs-2271	158	22	haitham	haitham	PROPN
iajs-2271	158	23	jour	jour	X
iajs-2271	158	24	.	.	PROPN
iajs-2271	159	1	for	for	ADP
iajs-2271	159	2	pure	pure	ADJ
iajs-2271	159	3	&	&	CCONJ
iajs-2271	159	4	appl	appl	PROPN
iajs-2271	159	5	.	.	PUNCT
iajs-2271	160	1	sci	sci	PROPN
iajs-2271	160	2	.	.	PROPN
iajs-2271	160	3	32	32	NUM
iajs-2271	160	4	(	(	PUNCT
iajs-2271	160	5	3	3	NUM
iajs-2271	160	6	)	)	PUNCT
iajs-2271	160	7	2019	2019	NUM
iajs-2271	160	8	even	even	ADV
iajs-2271	160	9	with	with	ADP
iajs-2271	160	10	the	the	DET
iajs-2271	160	11	branched	branch	VERB
iajs-2271	160	12	-	-	PUNCT
iajs-2271	160	13	chain	chain	NOUN
iajs-2271	160	14	aminotransferase	aminotransferase	NOUN
iajs-2271	160	15	(	(	PUNCT
iajs-2271	160	16	ilve	ilve	NOUN
iajs-2271	160	17	)	)	PUNCT
iajs-2271	160	18	from	from	ADP
iajs-2271	160	19	the	the	DET
iajs-2271	160	20	crenarchaeota	crenarchaeota	PROPN
iajs-2271	160	21	pyrobaculum	pyrobaculum	NOUN
iajs-2271	160	22	aerophilum	aerophilum	ADJ
iajs-2271	160	23	.	.	PUNCT
iajs-2271	161	1	dual	dual	ADJ
iajs-2271	161	2	substrate	substrate	NOUN
iajs-2271	161	3	recognition	recognition	NOUN
iajs-2271	161	4	by	by	ADP
iajs-2271	161	5	bcats	bcat	NOUN
iajs-2271	161	6	is	be	AUX
iajs-2271	161	7	implemented	implement	VERB
iajs-2271	161	8	via	via	ADP
iajs-2271	161	9	the	the	DET
iajs-2271	161	10	“	"	PUNCT
iajs-2271	161	11	lock	lock	NOUN
iajs-2271	161	12	and	and	CCONJ
iajs-2271	161	13	key	key	ADJ
iajs-2271	161	14	”	"	PUNCT
iajs-2271	161	15	mechanism	mechanism	NOUN
iajs-2271	161	16	without	without	ADP
iajs-2271	161	17	side	side	NOUN
iajs-2271	161	18	-	-	PUNCT
iajs-2271	161	19	chain	chain	NOUN
iajs-2271	161	20	rearrangements	rearrangement	NOUN
iajs-2271	161	21	of	of	ADP
iajs-2271	161	22	the	the	DET
iajs-2271	161	23	active	active	ADJ
iajs-2271	161	24	site	site	NOUN
iajs-2271	161	25	residues	residue	NOUN
iajs-2271	161	26	[	[	X
iajs-2271	161	27	30	30	NUM
iajs-2271	161	28	]	]	PUNCT
iajs-2271	161	29	.	.	PUNCT
iajs-2271	162	1	to	to	PART
iajs-2271	162	2	find	find	VERB
iajs-2271	162	3	the	the	DET
iajs-2271	162	4	candidate	candidate	NOUN
iajs-2271	162	5	gene	gene	NOUN
iajs-2271	162	6	encoding	encode	VERB
iajs-2271	162	7	this	this	DET
iajs-2271	162	8	enzyme	enzyme	NOUN
iajs-2271	162	9	in	in	ADP
iajs-2271	162	10	s.	s.	PROPN
iajs-2271	162	11	solfataricus	solfataricus	PROPN
iajs-2271	162	12	,	,	PUNCT
iajs-2271	162	13	the	the	DET
iajs-2271	162	14	relationship	relationship	NOUN
iajs-2271	162	15	among	among	ADP
iajs-2271	162	16	the	the	DET
iajs-2271	162	17	pathways	pathway	NOUN
iajs-2271	162	18	lysine	lysine	NOUN
iajs-2271	162	19	-	-	PUNCT
iajs-2271	162	20	aaa	aaa	NOUN
iajs-2271	162	21	,	,	PUNCT
iajs-2271	162	22	leucine	leucine	NOUN
iajs-2271	162	23	and	and	CCONJ
iajs-2271	162	24	arginine	arginine	NOUN
iajs-2271	162	25	was	be	AUX
iajs-2271	162	26	taken	take	VERB
iajs-2271	162	27	in	in	ADP
iajs-2271	162	28	consideration	consideration	NOUN
iajs-2271	162	29	.	.	PUNCT
iajs-2271	163	1	it	it	PRON
iajs-2271	163	2	was	be	AUX
iajs-2271	163	3	found	find	VERB
iajs-2271	163	4	that	that	SCONJ
iajs-2271	163	5	lysine	lysine	NOUN
iajs-2271	163	6	-	-	PUNCT
iajs-2271	163	7	aaa	aaa	NOUN
iajs-2271	163	8	gene	gene	NOUN
iajs-2271	163	9	cluster	cluster	NOUN
iajs-2271	163	10	was	be	AUX
iajs-2271	163	11	analogous	analogous	ADJ
iajs-2271	163	12	in	in	ADP
iajs-2271	163	13	part	part	NOUN
iajs-2271	163	14	to	to	ADP
iajs-2271	163	15	the	the	DET
iajs-2271	163	16	leucine	leucine	NOUN
iajs-2271	163	17	and	and	CCONJ
iajs-2271	163	18	arginine	arginine	X
iajs-2271	163	19	biosynthetic	biosynthetic	ADJ
iajs-2271	163	20	pathways	pathway	NOUN
iajs-2271	164	1	[	[	X
iajs-2271	164	2	31	31	NUM
iajs-2271	164	3	]	]	PUNCT
iajs-2271	164	4	.	.	PUNCT
iajs-2271	165	1	and	and	CCONJ
iajs-2271	165	2	they	they	PRON
iajs-2271	165	3	found	find	VERB
iajs-2271	165	4	that	that	SCONJ
iajs-2271	165	5	the	the	DET
iajs-2271	165	6	genes	gene	NOUN
iajs-2271	165	7	evolutionarily	evolutionarily	ADV
iajs-2271	165	8	related	relate	VERB
iajs-2271	165	9	to	to	ADP
iajs-2271	165	10	lysine	lysine	NOUN
iajs-2271	165	11	-	-	PUNCT
iajs-2271	165	12	aaa	aaa	NOUN
iajs-2271	165	13	biosynthetic	biosynthetic	ADJ
iajs-2271	165	14	genes	gene	NOUN
iajs-2271	165	15	in	in	ADP
iajs-2271	165	16	t.	t.	NOUN
iajs-2271	165	17	thermophilus	thermophilus	NOUN
iajs-2271	165	18	were	be	AUX
iajs-2271	165	19	all	all	ADV
iajs-2271	165	20	present	present	ADJ
iajs-2271	165	21	in	in	ADP
iajs-2271	165	22	the	the	DET
iajs-2271	165	23	archaea	archaea	ADJ
iajs-2271	165	24	pyrococcus	pyrococcus	ADJ
iajs-2271	165	25	horikoshii	horikoshii	NOUN
iajs-2271	165	26	.	.	PUNCT
iajs-2271	166	1	from	from	ADP
iajs-2271	166	2	this	this	DET
iajs-2271	166	3	point	point	NOUN
iajs-2271	166	4	of	of	ADP
iajs-2271	166	5	view	view	NOUN
iajs-2271	166	6	,	,	PUNCT
iajs-2271	166	7	it	it	PRON
iajs-2271	166	8	was	be	AUX
iajs-2271	166	9	found	find	VERB
iajs-2271	166	10	that	that	SCONJ
iajs-2271	166	11	the	the	DET
iajs-2271	166	12	analogous	analogous	ADJ
iajs-2271	166	13	gene	gene	NOUN
iajs-2271	166	14	to	to	PART
iajs-2271	166	15	ilve	ilve	VERB
iajs-2271	166	16	in	in	ADP
iajs-2271	166	17	leucine	leucine	NOUN
iajs-2271	166	18	pathway	pathway	NOUN
iajs-2271	166	19	was	be	AUX
iajs-2271	166	20	lysn	lysn	ADJ
iajs-2271	166	21	(	(	PUNCT
iajs-2271	166	22	lysn	lysn	ADJ
iajs-2271	166	23	,	,	PUNCT
iajs-2271	166	24	alphaaminoadipate	alphaaminoadipate	ADJ
iajs-2271	166	25	aminotransferase	aminotransferase	PROPN
iajs-2271	166	26	(	(	PUNCT
iajs-2271	166	27	aaaat	aaaat	PROPN
iajs-2271	166	28	)	)	PUNCT
iajs-2271	166	29	,	,	PUNCT
iajs-2271	166	30	ec	ec	PROPN
iajs-2271	166	31	2.6.1.39	2.6.1.39	PROPN
iajs-2271	166	32	)	)	PUNCT
iajs-2271	166	33	in	in	ADP
iajs-2271	166	34	lysine	lysine	NOUN
iajs-2271	166	35	-	-	PUNCT
iajs-2271	166	36	aaa	aaa	NOUN
iajs-2271	166	37	pathway	pathway	NOUN
iajs-2271	167	1	[	[	X
iajs-2271	167	2	32	32	NUM
iajs-2271	167	3	]	]	PUNCT
iajs-2271	167	4	.	.	PUNCT
iajs-2271	168	1	lysn	lysn	PROPN
iajs-2271	168	2	recognizes	recognize	VERB
iajs-2271	168	3	not	not	PART
iajs-2271	168	4	only	only	ADV
iajs-2271	168	5	2	2	NUM
iajs-2271	168	6	-	-	PUNCT
iajs-2271	168	7	oxoadipate	oxoadipate	ADJ
iajs-2271	168	8	,	,	PUNCT
iajs-2271	168	9	an	an	DET
iajs-2271	168	10	intermediate	intermediate	ADJ
iajs-2271	168	11	of	of	ADP
iajs-2271	168	12	lysine	lysine	NOUN
iajs-2271	168	13	biosynthesis	biosynthesis	NOUN
iajs-2271	168	14	,	,	PUNCT
iajs-2271	168	15	but	but	CCONJ
iajs-2271	168	16	also	also	ADV
iajs-2271	168	17	2oxoisocaproate	2oxoisocaproate	NUM
iajs-2271	168	18	,	,	PUNCT
iajs-2271	168	19	2	2	NUM
iajs-2271	168	20	-	-	PUNCT
iajs-2271	168	21	oxoisovalerate	oxoisovalerate	NOUN
iajs-2271	168	22	and	and	CCONJ
iajs-2271	168	23	2	2	NUM
iajs-2271	168	24	-	-	PUNCT
iajs-2271	168	25	oxo-3	oxo-3	NOUN
iajs-2271	168	26	-	-	PUNCT
iajs-2271	168	27	methylvalerate	methylvalerate	NOUN
iajs-2271	168	28	,	,	PUNCT
iajs-2271	168	29	intermediates	intermediate	NOUN
iajs-2271	168	30	of	of	ADP
iajs-2271	168	31	leucine	leucine	NOUN
iajs-2271	168	32	,	,	PUNCT
iajs-2271	168	33	valine	valine	NOUN
iajs-2271	168	34	and	and	CCONJ
iajs-2271	168	35	isoleucine	isoleucine	NOUN
iajs-2271	168	36	biosyntheses	biosynthese	NOUN
iajs-2271	169	1	[	[	X
iajs-2271	169	2	33	33	NUM
iajs-2271	169	3	]	]	PUNCT
iajs-2271	169	4	.	.	PUNCT
iajs-2271	170	1	they	they	PRON
iajs-2271	170	2	found	find	VERB
iajs-2271	170	3	also	also	ADV
iajs-2271	170	4	that	that	PRON
iajs-2271	170	5	lysn	lysn	ADJ
iajs-2271	170	6	and	and	CCONJ
iajs-2271	170	7	aspartate	aspartate	NOUN
iajs-2271	170	8	aminotransferase	aminotransferase	NOUN
iajs-2271	170	9	(	(	PUNCT
iajs-2271	170	10	aspat	aspat	PROPN
iajs-2271	170	11	)	)	PUNCT
iajs-2271	170	12	share	share	VERB
iajs-2271	170	13	the	the	DET
iajs-2271	170	14	same	same	ADJ
iajs-2271	170	15	common	common	ADJ
iajs-2271	170	16	ancestor	ancestor	NOUN
iajs-2271	170	17	.	.	PUNCT
iajs-2271	171	1	when	when	SCONJ
iajs-2271	171	2	aaaat	aaaat	PROPN
iajs-2271	171	3	(	(	PUNCT
iajs-2271	171	4	st1411	st1411	PROPN
iajs-2271	171	5	)	)	PUNCT
iajs-2271	171	6	and	and	CCONJ
iajs-2271	171	7	aspat	aspat	NOUN
iajs-2271	171	8	(	(	PUNCT
iajs-2271	171	9	st1225	st1225	PROPN
iajs-2271	171	10	)	)	PUNCT
iajs-2271	171	11	in	in	ADP
iajs-2271	171	12	sulfolobus	sulfolobus	NOUN
iajs-2271	171	13	tokodai	tokodai	NOUN
iajs-2271	171	14	were	be	AUX
iajs-2271	171	15	searched	search	VERB
iajs-2271	171	16	in	in	ADP
iajs-2271	171	17	the	the	DET
iajs-2271	171	18	s.	s.	PROPN
iajs-2271	171	19	solfataricus	solfataricus	PROPN
iajs-2271	171	20	p2	p2	PROPN
iajs-2271	171	21	genome	genome	NOUN
iajs-2271	171	22	for	for	ADP
iajs-2271	171	23	their	their	PRON
iajs-2271	171	24	homologous	homologous	ADJ
iajs-2271	171	25	genes	gene	NOUN
iajs-2271	171	26	,	,	PUNCT
iajs-2271	171	27	the	the	DET
iajs-2271	171	28	both	both	DET
iajs-2271	171	29	searches	search	NOUN
iajs-2271	171	30	retrieved	retrieve	VERB
iajs-2271	171	31	again	again	ADV
iajs-2271	171	32	the	the	DET
iajs-2271	171	33	aspartate	aspartate	NOUN
iajs-2271	171	34	aminotransferase	aminotransferase	NOUN
iajs-2271	171	35	(	(	PUNCT
iajs-2271	171	36	aspb-1	aspb-1	PROPN
iajs-2271	171	37	"	"	PUNCT
iajs-2271	171	38	sso0104	sso0104	NOUN
iajs-2271	171	39	"	"	PUNCT
iajs-2271	171	40	,	,	PUNCT
iajs-2271	171	41	aspb-2	aspb-2	ADV
iajs-2271	171	42	"	"	PUNCT
iajs-2271	171	43	sso0897	sso0897	NOUN
iajs-2271	171	44	"	"	PUNCT
iajs-2271	171	45	,	,	PUNCT
iajs-2271	171	46	aspb-3	aspb-3	DET
iajs-2271	171	47	"	"	PUNCT
iajs-2271	171	48	sso1177	sso1177	NOUN
iajs-2271	171	49	"	"	PUNCT
iajs-2271	171	50	,	,	PUNCT
iajs-2271	171	51	aspb-4	aspb-4	PUNCT
iajs-2271	171	52	"	"	PUNCT
iajs-2271	171	53	sso3245	sso3245	NOUN
iajs-2271	171	54	"	"	PUNCT
iajs-2271	171	55	)	)	PUNCT
iajs-2271	171	56	.	.	PUNCT
iajs-2271	172	1	the	the	DET
iajs-2271	172	2	curated	curate	VERB
iajs-2271	172	3	super	super	ADJ
iajs-2271	172	4	pathway	pathway	NOUN
iajs-2271	172	5	of	of	ADP
iajs-2271	172	6	branched	branch	VERB
iajs-2271	172	7	-	-	PUNCT
iajs-2271	172	8	chain	chain	NOUN
iajs-2271	172	9	amino	amino	NOUN
iajs-2271	172	10	acids	acid	NOUN
iajs-2271	172	11	biosynthesis	biosynthesis	NOUN
iajs-2271	172	12	(	(	PUNCT
iajs-2271	172	13	leucine	leucine	NOUN
iajs-2271	172	14	,	,	PUNCT
iajs-2271	172	15	isoleucine	isoleucine	NOUN
iajs-2271	172	16	and	and	CCONJ
iajs-2271	172	17	valine	valine	NOUN
iajs-2271	172	18	)	)	PUNCT
iajs-2271	172	19	is	be	AUX
iajs-2271	172	20	shown	show	VERB
iajs-2271	172	21	in	in	ADP
iajs-2271	172	22	figure	figure	NOUN
iajs-2271	172	23	4	4	NUM
iajs-2271	172	24	.	.	PUNCT
iajs-2271	173	1	the	the	DET
iajs-2271	173	2	ec	ec	PROPN
iajs-2271	173	3	4.1.3.12	4.1.3.12	PROPN
iajs-2271	173	4	is	be	AUX
iajs-2271	173	5	exchanged	exchange	VERB
iajs-2271	173	6	by	by	ADP
iajs-2271	173	7	ec	ec	PROPN
iajs-2271	173	8	2.3.3.13	2.3.3.13	NUM
iajs-2271	173	9	.	.	PUNCT
iajs-2271	174	1	10	10	NUM
iajs-2271	174	2	ibn	ibn	PROPN
iajs-2271	174	3	al	al	PROPN
iajs-2271	174	4	-	-	PUNCT
iajs-2271	174	5	haitham	haitham	PROPN
iajs-2271	174	6	jour	jour	X
iajs-2271	174	7	.	.	PROPN
iajs-2271	174	8	for	for	ADP
iajs-2271	174	9	pure	pure	ADJ
iajs-2271	174	10	&	&	CCONJ
iajs-2271	174	11	appl	appl	PROPN
iajs-2271	174	12	.	.	PUNCT
iajs-2271	175	1	sci	sci	PROPN
iajs-2271	175	2	.	.	PROPN
iajs-2271	175	3	32	32	NUM
iajs-2271	175	4	(	(	PUNCT
iajs-2271	175	5	3	3	NUM
iajs-2271	175	6	)	)	PUNCT
iajs-2271	175	7	2019	2019	NUM
iajs-2271	175	8	figure	figure	NOUN
iajs-2271	175	9	3	3	NUM
iajs-2271	175	10	.	.	PUNCT
iajs-2271	175	11	curated	curate	VERB
iajs-2271	175	12	super	super	ADJ
iajs-2271	175	13	pathway	pathway	NOUN
iajs-2271	175	14	of	of	ADP
iajs-2271	175	15	phenylalanine	phenylalanine	NOUN
iajs-2271	175	16	,	,	PUNCT
iajs-2271	175	17	tyrosine	tyrosine	NOUN
iajs-2271	175	18	and	and	CCONJ
iajs-2271	175	19	tryptophan	tryptophan	NOUN
iajs-2271	175	20	biosynthesis	biosynthesis	NOUN
iajs-2271	175	21	from	from	ADP
iajs-2271	175	22	chorismate	chorismate	NOUN
iajs-2271	175	23	(	(	PUNCT
iajs-2271	175	24	for	for	ADP
iajs-2271	175	25	chorismate	chorismate	ADJ
iajs-2271	175	26	biosynthesis	biosynthesis	NOUN
iajs-2271	175	27	,	,	PUNCT
iajs-2271	175	28	see	see	VERB
iajs-2271	175	29	figure	figure	NOUN
iajs-2271	175	30	2	2	NUM
iajs-2271	175	31	)	)	PUNCT
iajs-2271	175	32	.	.	PUNCT
iajs-2271	176	1	3.2.3	3.2.3	X
iajs-2271	176	2	.	.	X
iajs-2271	176	3	individual	individual	ADJ
iajs-2271	176	4	amino	amino	NOUN
iajs-2271	176	5	acid	acid	NOUN
iajs-2271	176	6	biosynthetic	biosynthetic	ADJ
iajs-2271	176	7	pathways	pathway	NOUN
iajs-2271	176	8	nishida	nishida	NOUN
iajs-2271	177	1	[	[	X
iajs-2271	177	2	31	31	NUM
iajs-2271	177	3	]	]	PUNCT
iajs-2271	177	4	.	.	PUNCT
iajs-2271	178	1	proposed	propose	VERB
iajs-2271	178	2	a	a	DET
iajs-2271	178	3	modified	modified	ADJ
iajs-2271	178	4	variant	variant	NOUN
iajs-2271	178	5	of	of	ADP
iajs-2271	178	6	alpha	alpha	NOUN
iajs-2271	178	7	-	-	PUNCT
iajs-2271	178	8	aminoadipic	aminoadipic	ADJ
iajs-2271	178	9	acid	acid	NOUN
iajs-2271	178	10	(	(	PUNCT
iajs-2271	178	11	aaa	aaa	NOUN
iajs-2271	178	12	)	)	PUNCT
iajs-2271	178	13	pathway	pathway	NOUN
iajs-2271	178	14	of	of	ADP
iajs-2271	178	15	lysine	lysine	NOUN
iajs-2271	178	16	biosynthesis	biosynthesis	NOUN
iajs-2271	178	17	for	for	ADP
iajs-2271	178	18	the	the	DET
iajs-2271	178	19	hyperthermophilic	hyperthermophilic	ADJ
iajs-2271	178	20	archaeon	archaeon	NOUN
iajs-2271	178	21	pyrococcus	pyrococcus	PROPN
iajs-2271	178	22	horikoshii	horikoshii	PROPN
iajs-2271	178	23	.	.	PUNCT
iajs-2271	179	1	although	although	SCONJ
iajs-2271	179	2	the	the	DET
iajs-2271	179	3	diaminopimelic	diaminopimelic	ADJ
iajs-2271	179	4	acid	acid	NOUN
iajs-2271	179	5	(	(	PUNCT
iajs-2271	179	6	dap	dap	PROPN
iajs-2271	179	7	)	)	PUNCT
iajs-2271	179	8	pathway	pathway	NOUN
iajs-2271	179	9	of	of	ADP
iajs-2271	179	10	lysine	lysine	NOUN
iajs-2271	179	11	biosynthesis	biosynthesis	NOUN
iajs-2271	179	12	was	be	AUX
iajs-2271	179	13	already	already	ADV
iajs-2271	179	14	detected	detect	VERB
iajs-2271	179	15	by	by	ADP
iajs-2271	179	16	the	the	DET
iajs-2271	179	17	pathologic	pathologic	NOUN
iajs-2271	179	18	of	of	ADP
iajs-2271	179	19	the	the	DET
iajs-2271	179	20	pathway	pathway	NOUN
iajs-2271	179	21	tools	tool	NOUN
iajs-2271	179	22	,	,	PUNCT
iajs-2271	179	23	the	the	DET
iajs-2271	179	24	aaa	aaa	NOUN
iajs-2271	179	25	pathway	pathway	NOUN
iajs-2271	179	26	was	be	AUX
iajs-2271	179	27	not	not	PART
iajs-2271	179	28	created	create	VERB
iajs-2271	179	29	in	in	ADP
iajs-2271	179	30	the	the	DET
iajs-2271	179	31	pgdb	pgdb	NOUN
iajs-2271	179	32	of	of	ADP
iajs-2271	179	33	s.	s.	PROPN
iajs-2271	179	34	solfataricus	solfataricus	PROPN
iajs-2271	179	35	p2	p2	PROPN
iajs-2271	179	36	because	because	SCONJ
iajs-2271	179	37	many	many	ADJ
iajs-2271	179	38	catalyzing	catalyzing	NOUN
iajs-2271	179	39	enzymes	enzyme	NOUN
iajs-2271	179	40	of	of	ADP
iajs-2271	179	41	this	this	DET
iajs-2271	179	42	pathway	pathway	NOUN
iajs-2271	179	43	are	be	AUX
iajs-2271	179	44	absent	absent	ADJ
iajs-2271	179	45	in	in	ADP
iajs-2271	179	46	s.	s.	PROPN
iajs-2271	179	47	solfataricus	solfataricus	PROPN
iajs-2271	179	48	p2	p2	PROPN
iajs-2271	179	49	genome	genome	NOUN
iajs-2271	179	50	.	.	PUNCT
iajs-2271	180	1	11	11	NUM
iajs-2271	181	1	ibn	ibn	PROPN
iajs-2271	181	2	al	al	PROPN
iajs-2271	181	3	-	-	PUNCT
iajs-2271	181	4	haitham	haitham	PROPN
iajs-2271	181	5	jour	jour	X
iajs-2271	181	6	.	.	PROPN
iajs-2271	181	7	for	for	ADP
iajs-2271	181	8	pure	pure	ADJ
iajs-2271	181	9	&	&	CCONJ
iajs-2271	181	10	appl	appl	PROPN
iajs-2271	181	11	.	.	PUNCT
iajs-2271	182	1	sci	sci	PROPN
iajs-2271	182	2	.	.	PROPN
iajs-2271	182	3	32	32	NUM
iajs-2271	182	4	(	(	PUNCT
iajs-2271	182	5	3	3	NUM
iajs-2271	182	6	)	)	PUNCT
iajs-2271	182	7	2019	2019	NUM
iajs-2271	182	8	figure	figure	NOUN
iajs-2271	182	9	4	4	NUM
iajs-2271	182	10	.	.	NUM
iajs-2271	182	11	curated	curate	VERB
iajs-2271	182	12	super	super	ADJ
iajs-2271	182	13	pathway	pathway	NOUN
iajs-2271	182	14	of	of	ADP
iajs-2271	182	15	branched	branch	VERB
iajs-2271	182	16	-	-	PUNCT
iajs-2271	182	17	chain	chain	NOUN
iajs-2271	182	18	amino	amino	NOUN
iajs-2271	182	19	acids	acid	NOUN
iajs-2271	182	20	biosynthesis	biosynthesis	NOUN
iajs-2271	182	21	(	(	PUNCT
iajs-2271	182	22	leucine	leucine	NOUN
iajs-2271	182	23	,	,	PUNCT
iajs-2271	182	24	isoleucine	isoleucine	NOUN
iajs-2271	182	25	and	and	CCONJ
iajs-2271	182	26	valine	valine	NOUN
iajs-2271	182	27	)	)	PUNCT
iajs-2271	182	28	.	.	PUNCT
iajs-2271	183	1	12	12	NUM
iajs-2271	183	2	ibn	ibn	PROPN
iajs-2271	183	3	al	al	PROPN
iajs-2271	183	4	-	-	PUNCT
iajs-2271	183	5	haitham	haitham	PROPN
iajs-2271	183	6	jour	jour	X
iajs-2271	183	7	.	.	PROPN
iajs-2271	183	8	for	for	ADP
iajs-2271	183	9	pure	pure	ADJ
iajs-2271	183	10	&	&	CCONJ
iajs-2271	183	11	appl	appl	PROPN
iajs-2271	183	12	.	.	PUNCT
iajs-2271	184	1	sci	sci	PROPN
iajs-2271	184	2	.	.	PROPN
iajs-2271	184	3	32	32	NUM
iajs-2271	184	4	(	(	PUNCT
iajs-2271	184	5	3	3	NUM
iajs-2271	184	6	)	)	PUNCT
iajs-2271	184	7	2019	2019	NUM
iajs-2271	184	8	that	that	PRON
iajs-2271	184	9	’s	’	VERB
iajs-2271	184	10	why	why	SCONJ
iajs-2271	184	11	a	a	DET
iajs-2271	184	12	putative	putative	ADJ
iajs-2271	184	13	aaa	aaa	NOUN
iajs-2271	184	14	pathway	pathway	NOUN
iajs-2271	184	15	was	be	AUX
iajs-2271	184	16	created	create	VERB
iajs-2271	184	17	and	and	CCONJ
iajs-2271	184	18	added	add	VERB
iajs-2271	184	19	to	to	ADP
iajs-2271	184	20	the	the	DET
iajs-2271	184	21	s.	s.	PROPN
iajs-2271	184	22	solfataricus	solfataricus	PROPN
iajs-2271	184	23	pgdb	pgdb	PROPN
iajs-2271	184	24	figure	figure	NOUN
iajs-2271	184	25	5	5	NUM
iajs-2271	184	26	.	.	PUNCT
iajs-2271	185	1	the	the	DET
iajs-2271	185	2	clear	clear	ADJ
iajs-2271	185	3	relationship	relationship	NOUN
iajs-2271	185	4	among	among	ADP
iajs-2271	185	5	aaa	aaa	NOUN
iajs-2271	185	6	-	-	PUNCT
iajs-2271	185	7	lysine	lysine	NOUN
iajs-2271	185	8	,	,	PUNCT
iajs-2271	185	9	leucine	leucine	NOUN
iajs-2271	185	10	and	and	CCONJ
iajs-2271	185	11	arginine	arginine	VERB
iajs-2271	185	12	pathways	pathway	NOUN
iajs-2271	186	1	[	[	X
iajs-2271	186	2	31,32	31,32	NUM
iajs-2271	186	3	]	]	PUNCT
iajs-2271	186	4	.	.	PUNCT
iajs-2271	187	1	and	and	CCONJ
iajs-2271	187	2	the	the	DET
iajs-2271	187	3	identified	identify	VERB
iajs-2271	187	4	aaa	aaa	NOUN
iajs-2271	187	5	pathway	pathway	NOUN
iajs-2271	187	6	enzymes	enzyme	NOUN
iajs-2271	187	7	from	from	ADP
iajs-2271	187	8	pyrococcus	pyrococcus	ADJ
iajs-2271	187	9	horikoshii	horikoshii	PROPN
iajs-2271	187	10	helped	help	VERB
iajs-2271	187	11	in	in	ADP
iajs-2271	187	12	the	the	DET
iajs-2271	187	13	identification	identification	NOUN
iajs-2271	187	14	of	of	ADP
iajs-2271	187	15	the	the	DET
iajs-2271	187	16	aaa	aaa	NOUN
iajs-2271	187	17	pathway	pathway	NOUN
iajs-2271	187	18	enzymes	enzyme	NOUN
iajs-2271	187	19	for	for	ADP
iajs-2271	187	20	s.	s.	PROPN
iajs-2271	187	21	solfataricus	solfataricus	PROPN
iajs-2271	187	22	p2	p2	PROPN
iajs-2271	187	23	.	.	PUNCT
iajs-2271	188	1	figure	figure	NOUN
iajs-2271	188	2	5	5	NUM
iajs-2271	188	3	.	.	PUNCT
iajs-2271	189	1	the	the	DET
iajs-2271	189	2	created	create	VERB
iajs-2271	189	3	alpha	alpha	NOUN
iajs-2271	189	4	-	-	PUNCT
iajs-2271	189	5	aminoadipic	aminoadipic	ADJ
iajs-2271	189	6	acid	acid	NOUN
iajs-2271	189	7	(	(	PUNCT
iajs-2271	189	8	aaa	aaa	NOUN
iajs-2271	189	9	)	)	PUNCT
iajs-2271	189	10	pathway	pathway	NOUN
iajs-2271	189	11	of	of	ADP
iajs-2271	189	12	lysine	lysine	NOUN
iajs-2271	189	13	biosynthesis	biosynthesis	NOUN
iajs-2271	189	14	in	in	ADP
iajs-2271	189	15	s.	s.	PROPN
iajs-2271	189	16	solfataricus	solfataricus	PROPN
iajs-2271	189	17	.	.	PUNCT
iajs-2271	190	1	the	the	DET
iajs-2271	190	2	broad	broad	ADJ
iajs-2271	190	3	substrate	substrate	NOUN
iajs-2271	190	4	specificity	specificity	NOUN
iajs-2271	190	5	of	of	ADP
iajs-2271	190	6	aspartate	aspartate	ADJ
iajs-2271	190	7	aminotransferase	aminotransferase	NOUN
iajs-2271	190	8	[	[	X
iajs-2271	190	9	34,35	34,35	NOUN
iajs-2271	190	10	]	]	PUNCT
iajs-2271	190	11	.	.	PUNCT
iajs-2271	191	1	allowed	allow	VERB
iajs-2271	191	2	the	the	DET
iajs-2271	191	3	assignment	assignment	NOUN
iajs-2271	191	4	of	of	ADP
iajs-2271	191	5	its	its	PRON
iajs-2271	191	6	enzymatic	enzymatic	ADJ
iajs-2271	191	7	function	function	NOUN
iajs-2271	191	8	to	to	ADP
iajs-2271	191	9	the	the	DET
iajs-2271	191	10	reactions	reaction	NOUN
iajs-2271	191	11	(	(	PUNCT
iajs-2271	191	12	ec	ec	PROPN
iajs-2271	191	13	2.6.1.66	2.6.1.66	PROPN
iajs-2271	191	14	)	)	PUNCT
iajs-2271	191	15	and	and	CCONJ
iajs-2271	191	16	(	(	PUNCT
iajs-2271	191	17	ec	ec	PROPN
iajs-2271	191	18	2.6.1.2	2.6.1.2	NUM
iajs-2271	191	19	)	)	PUNCT
iajs-2271	191	20	in	in	ADP
iajs-2271	191	21	alanine	alanine	NOUN
iajs-2271	191	22	biosynthetic	biosynthetic	ADJ
iajs-2271	191	23	pathway	pathway	NOUN
iajs-2271	191	24	(	(	PUNCT
iajs-2271	191	25	three	three	NUM
iajs-2271	191	26	variations	variation	NOUN
iajs-2271	191	27	were	be	AUX
iajs-2271	191	28	created	create	VERB
iajs-2271	191	29	)	)	PUNCT
iajs-2271	191	30	figure	figure	NOUN
iajs-2271	191	31	6	6	NUM
iajs-2271	191	32	.	.	PUNCT
iajs-2271	192	1	and	and	CCONJ
iajs-2271	192	2	to	to	ADP
iajs-2271	192	3	(	(	PUNCT
iajs-2271	192	4	ec	ec	PROPN
iajs-2271	192	5	2.6.1.4	2.6.1.4	NUM
iajs-2271	192	6	)	)	PUNCT
iajs-2271	192	7	in	in	ADP
iajs-2271	192	8	glycine	glycine	NOUN
iajs-2271	192	9	biosynthesis	biosynthesis	NOUN
iajs-2271	192	10	figure	figure	NOUN
iajs-2271	192	11	7	7	NUM
iajs-2271	192	12	.	.	PUNCT
iajs-2271	193	1	and	and	CCONJ
iajs-2271	193	2	also	also	ADV
iajs-2271	193	3	to	to	ADP
iajs-2271	193	4	the	the	DET
iajs-2271	193	5	ec	ec	NOUN
iajs-2271	193	6	-	-	PUNCT
iajs-2271	193	7	numbers	number	NOUN
iajs-2271	193	8	in	in	ADP
iajs-2271	193	9	other	other	ADJ
iajs-2271	193	10	missing	missing	ADJ
iajs-2271	193	11	steps	step	NOUN
iajs-2271	193	12	of	of	ADP
iajs-2271	193	13	the	the	DET
iajs-2271	193	14	aromatic	aromatic	ADJ
iajs-2271	193	15	and	and	CCONJ
iajs-2271	193	16	branched	branched	ADJ
iajs-2271	193	17	-	-	PUNCT
iajs-2271	193	18	chain	chain	NOUN
iajs-2271	193	19	amino	amino	NOUN
iajs-2271	193	20	acids	acid	NOUN
iajs-2271	193	21	biosynthesis	biosynthesis	NOUN
iajs-2271	193	22	table	table	NOUN
iajs-2271	193	23	1	1	NUM
iajs-2271	193	24	.	.	PUNCT
iajs-2271	194	1	the	the	DET
iajs-2271	194	2	homology	homology	NOUN
iajs-2271	194	3	search	search	NOUN
iajs-2271	194	4	of	of	ADP
iajs-2271	194	5	such	such	ADJ
iajs-2271	194	6	identified	identify	VERB
iajs-2271	194	7	enzymes	enzyme	NOUN
iajs-2271	194	8	from	from	ADP
iajs-2271	194	9	the	the	DET
iajs-2271	194	10	closely	closely	ADV
iajs-2271	194	11	related	relate	VERB
iajs-2271	194	12	archaea	archaea	NOUN
iajs-2271	194	13	in	in	ADP
iajs-2271	194	14	the	the	DET
iajs-2271	194	15	s.	s.	PROPN
iajs-2271	194	16	solfataricus	solfataricus	PROPN
iajs-2271	194	17	genome	genome	NOUN
iajs-2271	194	18	has	have	AUX
iajs-2271	194	19	always	always	ADV
iajs-2271	194	20	retrieved	retrieve	VERB
iajs-2271	194	21	aspartate	aspartate	NOUN
iajs-2271	194	22	aminotransferase	aminotransferase	NOUN
iajs-2271	194	23	(	(	PUNCT
iajs-2271	194	24	aspb-1	aspb-1	NUM
iajs-2271	194	25	to	to	ADP
iajs-2271	194	26	4	4	NUM
iajs-2271	194	27	)	)	PUNCT
iajs-2271	194	28	and	and	CCONJ
iajs-2271	194	29	no	no	DET
iajs-2271	194	30	other	other	ADJ
iajs-2271	194	31	specific	specific	ADJ
iajs-2271	194	32	sequences.the	sequences.the	DET
iajs-2271	194	33	previous	previous	ADJ
iajs-2271	194	34	mentioned	mention	VERB
iajs-2271	194	35	analogy	analogy	NOUN
iajs-2271	194	36	between	between	ADP
iajs-2271	194	37	lysine	lysine	NOUN
iajs-2271	194	38	biosynthesis	biosynthesis	NOUN
iajs-2271	194	39	(	(	PUNCT
iajs-2271	194	40	from	from	ADP
iajs-2271	194	41	alpha	alpha	NOUN
iajs-2271	194	42	-	-	PUNCT
iajs-2271	194	43	aminoadepate	aminoadepate	NOUN
iajs-2271	194	44	until	until	ADP
iajs-2271	194	45	lysine	lysine	NOUN
iajs-2271	194	46	production	production	NOUN
iajs-2271	194	47	)	)	PUNCT
iajs-2271	194	48	and	and	CCONJ
iajs-2271	194	49	arginine	arginine	NOUN
iajs-2271	194	50	biosynthesis	biosynthesis	NOUN
iajs-2271	194	51	(	(	PUNCT
iajs-2271	194	52	from	from	ADP
iajs-2271	194	53	glutamate	glutamate	NOUN
iajs-2271	194	54	to	to	ADP
iajs-2271	194	55	arginine	arginine	NOUN
iajs-2271	194	56	)	)	PUNCT
iajs-2271	194	57	and	and	CCONJ
iajs-2271	194	58	the	the	DET
iajs-2271	194	59	close	close	ADJ
iajs-2271	194	60	relation	relation	NOUN
iajs-2271	194	61	among	among	ADP
iajs-2271	194	62	the	the	DET
iajs-2271	194	63	enzymes	enzyme	NOUN
iajs-2271	194	64	involved	involve	VERB
iajs-2271	194	65	in	in	ADP
iajs-2271	194	66	both	both	DET
iajs-2271	194	67	pathways	pathway	NOUN
iajs-2271	194	68	led	lead	VERB
iajs-2271	194	69	to	to	ADP
iajs-2271	194	70	the	the	DET
iajs-2271	194	71	statement	statement	NOUN
iajs-2271	194	72	that	that	PRON
iajs-2271	194	73	argj	argj	PROPN
iajs-2271	194	74	is	be	AUX
iajs-2271	194	75	lysx	lysx	NOUN
iajs-2271	194	76	(	(	PUNCT
iajs-2271	194	77	rimk	rimk	PROPN
iajs-2271	194	78	)	)	PUNCT
iajs-2271	194	79	,	,	PUNCT
iajs-2271	194	80	(	(	PUNCT
iajs-2271	194	81	lysx	lysx	NOUN
iajs-2271	194	82	and	and	CCONJ
iajs-2271	194	83	rimk	rimk	NOUN
iajs-2271	194	84	are	be	AUX
iajs-2271	194	85	already	already	ADV
iajs-2271	194	86	annotated	annotate	VERB
iajs-2271	194	87	in	in	ADP
iajs-2271	194	88	s.	s.	PROPN
iajs-2271	194	89	solfataricus	solfataricus	PROPN
iajs-2271	194	90	p2	p2	PROPN
iajs-2271	194	91	genome	genome	NOUN
iajs-2271	194	92	)	)	PUNCT
iajs-2271	194	93	.	.	PUNCT
iajs-2271	195	1	and	and	CCONJ
iajs-2271	195	2	also	also	ADV
iajs-2271	195	3	argd	argd	NOUN
iajs-2271	195	4	is	be	AUX
iajs-2271	195	5	lysj	lysj	NOUN
iajs-2271	195	6	,	,	PUNCT
iajs-2271	195	7	and	and	CCONJ
iajs-2271	195	8	then	then	ADV
iajs-2271	195	9	the	the	DET
iajs-2271	195	10	both	both	PRON
iajs-2271	195	11	proteins	protein	NOUN
iajs-2271	195	12	lysx	lysx	NOUN
iajs-2271	195	13	/	/	SYM
iajs-2271	195	14	rimk	rimk	NOUN
iajs-2271	195	15	and	and	CCONJ
iajs-2271	195	16	argd	argd	NOUN
iajs-2271	195	17	/	/	SYM
iajs-2271	195	18	lysj	lysj	NOUN
iajs-2271	195	19	were	be	AUX
iajs-2271	195	20	assigned	assign	VERB
iajs-2271	195	21	to	to	ADP
iajs-2271	195	22	ec	ec	PROPN
iajs-2271	195	23	2.3.1.1	2.3.1.1	NUM
iajs-2271	195	24	and	and	CCONJ
iajs-2271	195	25	ec	ec	PROPN
iajs-2271	195	26	2.6.1.13	2.6.1.13	NUM
iajs-2271	195	27	,	,	PUNCT
iajs-2271	195	28	respectively	respectively	ADV
iajs-2271	195	29	in	in	ADP
iajs-2271	195	30	arginine	arginine	NOUN
iajs-2271	195	31	biosynthesis	biosynthesis	NOUN
iajs-2271	195	32	pathway	pathway	NOUN
iajs-2271	195	33	figure	figure	NOUN
iajs-2271	195	34	8	8	NUM
iajs-2271	195	35	.	.	PUNCT
iajs-2271	196	1	none	none	NOUN
iajs-2271	196	2	of	of	ADP
iajs-2271	196	3	meta	meta	X
iajs-2271	196	4	(	(	PUNCT
iajs-2271	196	5	ec	ec	PROPN
iajs-2271	196	6	2.3.1.46	2.3.1.46	NUM
iajs-2271	196	7	)	)	PUNCT
iajs-2271	196	8	and	and	CCONJ
iajs-2271	196	9	methionine	methionine	NOUN
iajs-2271	196	10	synthase	synthase	NOUN
iajs-2271	196	11	(	(	PUNCT
iajs-2271	196	12	ec	ec	PROPN
iajs-2271	196	13	2.1.1.13	2.1.1.13	NUM
iajs-2271	196	14	)	)	PUNCT
iajs-2271	196	15	was	be	AUX
iajs-2271	196	16	discovered	discover	VERB
iajs-2271	196	17	in	in	ADP
iajs-2271	196	18	s.	s.	PROPN
iajs-2271	196	19	solfataricus	solfataricus	PROPN
iajs-2271	196	20	p2	p2	PROPN
iajs-2271	196	21	genome	genome	NOUN
iajs-2271	196	22	,	,	PUNCT
iajs-2271	196	23	thus	thus	ADV
iajs-2271	196	24	the	the	DET
iajs-2271	196	25	route	route	NOUN
iajs-2271	196	26	homoserine	homoserine	NOUN
iajs-2271	196	27	and	and	CCONJ
iajs-2271	196	28	methionine	methionine	NOUN
iajs-2271	196	29	biosynthesis	biosynthesis	NOUN
iajs-2271	196	30	is	be	AUX
iajs-2271	196	31	the	the	DET
iajs-2271	196	32	most	most	ADV
iajs-2271	196	33	reliable	reliable	ADJ
iajs-2271	196	34	13	13	NUM
iajs-2271	196	35	ibn	ibn	PROPN
iajs-2271	196	36	al	al	PROPN
iajs-2271	196	37	-	-	PUNCT
iajs-2271	196	38	haitham	haitham	PROPN
iajs-2271	196	39	jour	jour	X
iajs-2271	196	40	.	.	PROPN
iajs-2271	197	1	for	for	ADP
iajs-2271	197	2	pure	pure	ADJ
iajs-2271	197	3	&	&	CCONJ
iajs-2271	197	4	appl	appl	PROPN
iajs-2271	197	5	.	.	PUNCT
iajs-2271	198	1	sci	sci	PROPN
iajs-2271	198	2	.	.	PROPN
iajs-2271	198	3	32	32	NUM
iajs-2271	198	4	(	(	PUNCT
iajs-2271	198	5	3	3	NUM
iajs-2271	198	6	)	)	SYM
iajs-2271	198	7	2019	2019	NUM
iajs-2271	198	8	pathway	pathway	NOUN
iajs-2271	198	9	for	for	ADP
iajs-2271	198	10	methionine	methionine	NOUN
iajs-2271	198	11	biosynthesis	biosynthesis	NOUN
iajs-2271	198	12	,	,	PUNCT
iajs-2271	198	13	in	in	ADP
iajs-2271	198	14	which	which	PRON
iajs-2271	198	15	metb	metb	ADV
iajs-2271	198	16	is	be	AUX
iajs-2271	198	17	responsible	responsible	ADJ
iajs-2271	198	18	for	for	ADP
iajs-2271	198	19	the	the	DET
iajs-2271	198	20	both	both	DET
iajs-2271	198	21	reactions	reaction	NOUN
iajs-2271	198	22	ec	ec	PROPN
iajs-2271	198	23	2.5.1.48	2.5.1.48	PROPN
iajs-2271	198	24	(	(	PUNCT
iajs-2271	198	25	formerly	formerly	ADV
iajs-2271	198	26	4.2.99.9	4.2.99.9	NUM
iajs-2271	198	27	)	)	PUNCT
iajs-2271	198	28	and	and	CCONJ
iajs-2271	198	29	ec	ec	PROPN
iajs-2271	198	30	4.4.1.8	4.4.1.8	NUM
iajs-2271	199	1	(	(	PUNCT
iajs-2271	199	2	supplementary	supplementary	ADJ
iajs-2271	199	3	figure	figure	NOUN
iajs-2271	199	4	1	1	NUM
iajs-2271	199	5	.	.	PUNCT
iajs-2271	199	6	)	)	PUNCT
iajs-2271	200	1	(	(	PUNCT
iajs-2271	200	2	see	see	VERB
iajs-2271	200	3	https://www.ncbi.nlm.nih.gov/structure/cdd/cog0626	https://www.ncbi.nlm.nih.gov/structure/cdd/cog0626	PROPN
iajs-2271	200	4	)	)	PUNCT
iajs-2271	200	5	.	.	PUNCT
iajs-2271	201	1	figure	figure	VERB
iajs-2271	201	2	6	6	NUM
iajs-2271	201	3	.	.	PUNCT
iajs-2271	201	4	three	three	NUM
iajs-2271	201	5	pathway	pathway	NOUN
iajs-2271	201	6	variants	variant	NOUN
iajs-2271	201	7	of	of	ADP
iajs-2271	201	8	alanine	alanine	NOUN
iajs-2271	201	9	biosynthesis	biosynthesis	NOUN
iajs-2271	201	10	(	(	PUNCT
iajs-2271	201	11	i	i	PROPN
iajs-2271	201	12	,	,	PUNCT
iajs-2271	201	13	ii	ii	PROPN
iajs-2271	201	14	and	and	CCONJ
iajs-2271	201	15	iii	iii	NUM
iajs-2271	201	16	)	)	PUNCT
iajs-2271	201	17	.	.	PUNCT
iajs-2271	202	1	figure	figure	VERB
iajs-2271	202	2	7	7	NUM
iajs-2271	202	3	.	.	PUNCT
iajs-2271	202	4	super	super	ADJ
iajs-2271	202	5	pathway	pathway	NOUN
iajs-2271	202	6	of	of	ADP
iajs-2271	202	7	glycine	glycine	NOUN
iajs-2271	202	8	,	,	PUNCT
iajs-2271	202	9	serine	serine	NOUN
iajs-2271	202	10	and	and	CCONJ
iajs-2271	202	11	alanine	alanine	NOUN
iajs-2271	202	12	biosynthesis	biosynthesis	NOUN
iajs-2271	202	13	.	.	PUNCT
iajs-2271	203	1	cysteine	cysteine	NOUN
iajs-2271	203	2	is	be	AUX
iajs-2271	203	3	produced	produce	VERB
iajs-2271	203	4	from	from	ADP
iajs-2271	203	5	serine	serine	NOUN
iajs-2271	203	6	via	via	ADP
iajs-2271	203	7	two	two	NUM
iajs-2271	203	8	steps	step	NOUN
iajs-2271	203	9	(	(	PUNCT
iajs-2271	203	10	supplementary	supplementary	ADJ
iajs-2271	203	11	figure	figure	NOUN
iajs-2271	203	12	2	2	NUM
iajs-2271	203	13	)	)	PUNCT
iajs-2271	203	14	.	.	PUNCT
iajs-2271	204	1	the	the	DET
iajs-2271	204	2	second	second	ADJ
iajs-2271	204	3	step	step	NOUN
iajs-2271	204	4	,	,	PUNCT
iajs-2271	204	5	which	which	PRON
iajs-2271	204	6	is	be	AUX
iajs-2271	204	7	catalyzed	catalyze	VERB
iajs-2271	204	8	by	by	ADP
iajs-2271	204	9	cysm	cysm	NOUN
iajs-2271	204	10	(	(	PUNCT
iajs-2271	204	11	ec	ec	PROPN
iajs-2271	204	12	4.2.99.8	4.2.99.8	PROPN
iajs-2271	204	13	changed	change	VERB
iajs-2271	204	14	to	to	ADP
iajs-2271	204	15	ec	ec	PROPN
iajs-2271	204	16	2.5.1.47	2.5.1.47	NUM
iajs-2271	204	17	)	)	PUNCT
iajs-2271	204	18	,	,	PUNCT
iajs-2271	204	19	was	be	AUX
iajs-2271	204	20	already	already	ADV
iajs-2271	204	21	detected	detect	VERB
iajs-2271	204	22	by	by	ADP
iajs-2271	204	23	pathologic	pathologic	NOUN
iajs-2271	204	24	.	.	PUNCT
iajs-2271	205	1	whereas	whereas	SCONJ
iajs-2271	205	2	it	it	PRON
iajs-2271	205	3	is	be	AUX
iajs-2271	205	4	difficult	difficult	ADJ
iajs-2271	205	5	to	to	PART
iajs-2271	205	6	recognize	recognize	VERB
iajs-2271	205	7	cyse	cyse	NOUN
iajs-2271	205	8	(	(	PUNCT
iajs-2271	205	9	catalyzes	catalyze	VERB
iajs-2271	205	10	first	first	ADJ
iajs-2271	205	11	step	step	NOUN
iajs-2271	205	12	)	)	PUNCT
iajs-2271	205	13	in	in	ADP
iajs-2271	205	14	s.	s.	PROPN
iajs-2271	205	15	solfataricus	solfataricus	VERB
iajs-2271	205	16	due	due	ADP
iajs-2271	205	17	to	to	ADP
iajs-2271	205	18	the	the	DET
iajs-2271	205	19	lack	lack	NOUN
iajs-2271	205	20	of	of	ADP
iajs-2271	205	21	homology	homology	NOUN
iajs-2271	205	22	with	with	ADP
iajs-2271	205	23	the	the	DET
iajs-2271	205	24	known	know	VERB
iajs-2271	205	25	cyse	cyse	NOUN
iajs-2271	205	26	of	of	ADP
iajs-2271	205	27	other	other	ADJ
iajs-2271	205	28	archaea	archaea	NOUN
iajs-2271	205	29	such	such	ADJ
iajs-2271	205	30	as	as	ADP
iajs-2271	205	31	methanosarcina	methanosarcina	PROPN
iajs-2271	205	32	sp	sp	PROPN
iajs-2271	205	33	.	.	PROPN
iajs-2271	205	34	,	,	PUNCT
iajs-2271	205	35	pyrococcus	pyrococcu	VERB
iajs-2271	205	36	abyssi	abyssi	ADJ
iajs-2271	205	37	and	and	CCONJ
iajs-2271	205	38	haloarcula	haloarcula	ADJ
iajs-2271	205	39	marismortui	marismortui	ADJ
iajs-2271	205	40	.	.	PUNCT
iajs-2271	206	1	sso0372	sso0372	PROPN
iajs-2271	206	2	can	can	AUX
iajs-2271	206	3	be	be	AUX
iajs-2271	206	4	taken	take	VERB
iajs-2271	206	5	as	as	ADP
iajs-2271	206	6	a	a	DET
iajs-2271	206	7	candidate	candidate	NOUN
iajs-2271	206	8	after	after	ADP
iajs-2271	206	9	domain	domain	NOUN
iajs-2271	206	10	alignments	alignment	NOUN
iajs-2271	206	11	(	(	PUNCT
iajs-2271	206	12	cog1045	cog1045	ADV
iajs-2271	206	13	)	)	PUNCT
iajs-2271	206	14	and	and	CCONJ
iajs-2271	206	15	its	its	PRON
iajs-2271	206	16	position	position	NOUN
iajs-2271	206	17	near	near	ADP
iajs-2271	206	18	to	to	ADP
iajs-2271	206	19	cysm	cysm	NOUN
iajs-2271	206	20	(	(	PUNCT
iajs-2271	206	21	sso0360	sso0360	NOUN
iajs-2271	206	22	)	)	PUNCT
iajs-2271	206	23	.	.	PUNCT
iajs-2271	207	1	14	14	NUM
iajs-2271	207	2	ibn	ibn	PROPN
iajs-2271	207	3	al	al	PROPN
iajs-2271	207	4	-	-	PUNCT
iajs-2271	207	5	haitham	haitham	PROPN
iajs-2271	207	6	jour	jour	X
iajs-2271	207	7	.	.	PROPN
iajs-2271	207	8	for	for	ADP
iajs-2271	207	9	pure	pure	ADJ
iajs-2271	207	10	&	&	CCONJ
iajs-2271	207	11	appl	appl	PROPN
iajs-2271	207	12	.	.	PUNCT
iajs-2271	208	1	sci	sci	PROPN
iajs-2271	208	2	.	.	PROPN
iajs-2271	208	3	32	32	NUM
iajs-2271	208	4	(	(	PUNCT
iajs-2271	208	5	3	3	NUM
iajs-2271	208	6	)	)	PUNCT
iajs-2271	208	7	2019	2019	NUM
iajs-2271	208	8	figure	figure	NOUN
iajs-2271	208	9	8	8	NUM
iajs-2271	208	10	.	.	NOUN
iajs-2271	208	11	arginine	arginine	NOUN
iajs-2271	208	12	biosynthesis	biosynthesis	VERB
iajs-2271	208	13	from	from	ADP
iajs-2271	208	14	glutamate	glutamate	NOUN
iajs-2271	208	15	.	.	PUNCT
iajs-2271	209	1	15	15	NUM
iajs-2271	209	2	ibn	ibn	PROPN
iajs-2271	209	3	al	al	PROPN
iajs-2271	209	4	-	-	PUNCT
iajs-2271	209	5	haitham	haitham	PROPN
iajs-2271	209	6	jour	jour	X
iajs-2271	209	7	.	.	PROPN
iajs-2271	209	8	for	for	ADP
iajs-2271	209	9	pure	pure	ADJ
iajs-2271	209	10	&	&	CCONJ
iajs-2271	209	11	appl	appl	PROPN
iajs-2271	209	12	.	.	PUNCT
iajs-2271	210	1	sci	sci	PROPN
iajs-2271	210	2	.	.	PROPN
iajs-2271	210	3	32	32	NUM
iajs-2271	210	4	(	(	PUNCT
iajs-2271	210	5	3	3	NUM
iajs-2271	210	6	)	)	PUNCT
iajs-2271	210	7	2019	2019	NUM
iajs-2271	210	8	two	two	NUM
iajs-2271	210	9	super	super	ADJ
iajs-2271	210	10	pathways	pathway	NOUN
iajs-2271	210	11	(	(	PUNCT
iajs-2271	210	12	serine	serine	NOUN
iajs-2271	210	13	to	to	ADP
iajs-2271	210	14	glycine	glycine	NOUN
iajs-2271	210	15	and	and	CCONJ
iajs-2271	210	16	reverse	reverse	NOUN
iajs-2271	210	17	)	)	PUNCT
iajs-2271	210	18	were	be	AUX
iajs-2271	210	19	curated	curate	VERB
iajs-2271	210	20	and	and	CCONJ
iajs-2271	210	21	the	the	DET
iajs-2271	210	22	identified	identify	VERB
iajs-2271	210	23	candidate	candidate	NOUN
iajs-2271	210	24	enzymes	enzyme	NOUN
iajs-2271	210	25	table	table	NOUN
iajs-2271	210	26	1	1	NUM
iajs-2271	210	27	.	.	NUM
iajs-2271	210	28	were	be	AUX
iajs-2271	210	29	assigned	assign	VERB
iajs-2271	210	30	to	to	ADP
iajs-2271	210	31	the	the	DET
iajs-2271	210	32	corresponding	correspond	VERB
iajs-2271	210	33	ec	ec	NOUN
iajs-2271	210	34	-	-	PUNCT
iajs-2271	210	35	numbers	number	NOUN
iajs-2271	210	36	(	(	PUNCT
iajs-2271	210	37	supplementary	supplementary	ADJ
iajs-2271	210	38	figures	figure	NOUN
iajs-2271	210	39	.	.	PUNCT
iajs-2271	211	1	3	3	NUM
iajs-2271	211	2	,	,	PUNCT
iajs-2271	211	3	7	7	NUM
iajs-2271	211	4	)	)	PUNCT
iajs-2271	211	5	.	.	PUNCT
iajs-2271	212	1	the	the	DET
iajs-2271	212	2	unknown	unknown	ADJ
iajs-2271	212	3	ec	ec	NOUN
iajs-2271	212	4	-	-	PUNCT
iajs-2271	212	5	number	number	NOUN
iajs-2271	212	6	in	in	ADP
iajs-2271	212	7	proline	proline	NOUN
iajs-2271	212	8	biosynthesis	biosynthesis	NOUN
iajs-2271	212	9	pathway	pathway	NOUN
iajs-2271	212	10	was	be	AUX
iajs-2271	212	11	recognized	recognize	VERB
iajs-2271	212	12	from	from	ADP
iajs-2271	212	13	the	the	DET
iajs-2271	212	14	proline	proline	NOUN
iajs-2271	212	15	biosynthesis	biosynthesis	NOUN
iajs-2271	212	16	pathway	pathway	NOUN
iajs-2271	212	17	of	of	ADP
iajs-2271	212	18	other	other	ADJ
iajs-2271	212	19	organisms	organism	NOUN
iajs-2271	212	20	,	,	PUNCT
iajs-2271	212	21	and	and	CCONJ
iajs-2271	212	22	found	find	VERB
iajs-2271	212	23	to	to	PART
iajs-2271	212	24	be	be	AUX
iajs-2271	212	25	ec	ec	PROPN
iajs-2271	212	26	1.2.1.41	1.2.1.41	NUM
iajs-2271	212	27	(	(	PUNCT
iajs-2271	212	28	cog0014	cog0014	NOUN
iajs-2271	212	29	)	)	PUNCT
iajs-2271	212	30	.	.	PUNCT
iajs-2271	213	1	searching	search	VERB
iajs-2271	213	2	for	for	ADP
iajs-2271	213	3	gamma	gamma	NOUN
iajs-2271	213	4	-	-	PUNCT
iajs-2271	213	5	glutamyl	glutamyl	VERB
iajs-2271	213	6	phosphate	phosphate	ADJ
iajs-2271	213	7	reductase	reductase	NOUN
iajs-2271	213	8	(	(	PUNCT
iajs-2271	213	9	proa	proa	NOUN
iajs-2271	213	10	)	)	PUNCT
iajs-2271	213	11	from	from	ADP
iajs-2271	213	12	the	the	DET
iajs-2271	213	13	archaeon	archaeon	NOUN
iajs-2271	213	14	methanosarcina	methanosarcina	NOUN
iajs-2271	213	15	acetivorans	acetivoran	VERB
iajs-2271	213	16	in	in	ADP
iajs-2271	213	17	s.	s.	PROPN
iajs-2271	213	18	solfataricus	solfataricus	PROPN
iajs-2271	213	19	p2	p2	PROPN
iajs-2271	213	20	genome	genome	NOUN
iajs-2271	213	21	retrieved	retrieve	VERB
iajs-2271	213	22	aldehyde	aldehyde	NOUN
iajs-2271	213	23	dehydrogenase	dehydrogenase	NOUN
iajs-2271	213	24	(	(	PUNCT
iajs-2271	213	25	aldht	aldht	NOUN
iajs-2271	213	26	)	)	PUNCT
iajs-2271	213	27	(	(	PUNCT
iajs-2271	213	28	supplementary	supplementary	ADJ
iajs-2271	213	29	figure	figure	NOUN
iajs-2271	213	30	4	4	NUM
iajs-2271	213	31	)	)	PUNCT
iajs-2271	213	32	.	.	PUNCT
iajs-2271	214	1	nad	nad	ADJ
iajs-2271	214	2	specific	specific	ADJ
iajs-2271	214	3	glutamate	glutamate	NOUN
iajs-2271	214	4	dehydrogenase	dehydrogenase	NOUN
iajs-2271	214	5	(	(	PUNCT
iajs-2271	214	6	gdha	gdha	PROPN
iajs-2271	214	7	)	)	PUNCT
iajs-2271	214	8	from	from	ADP
iajs-2271	214	9	sulfolobus	sulfolobus	NOUN
iajs-2271	214	10	shibatae	shibatae	NOUN
iajs-2271	214	11	was	be	AUX
iajs-2271	214	12	searched	search	VERB
iajs-2271	214	13	in	in	ADP
iajs-2271	214	14	the	the	DET
iajs-2271	214	15	s.	s.	PROPN
iajs-2271	214	16	solfataricus	solfataricus	PROPN
iajs-2271	214	17	p2	p2	PROPN
iajs-2271	214	18	genome	genome	NOUN
iajs-2271	214	19	retrieving	retrieve	VERB
iajs-2271	214	20	(	(	PUNCT
iajs-2271	214	21	gdha-1”sso1457	gdha-1”sso1457	NOUN
iajs-2271	214	22	”	"	PUNCT
iajs-2271	214	23	)	)	PUNCT
iajs-2271	214	24	,	,	PUNCT
iajs-2271	214	25	(	(	PUNCT
iajs-2271	214	26	gdha-2	gdha-2	PROPN
iajs-2271	214	27	"	"	PUNCT
iajs-2271	214	28	sso1907	sso1907	NOUN
iajs-2271	214	29	"	"	PUNCT
iajs-2271	214	30	)	)	PUNCT
iajs-2271	214	31	,	,	PUNCT
iajs-2271	214	32	(	(	PUNCT
iajs-2271	214	33	gdha-3	gdha-3	PROPN
iajs-2271	214	34	"	"	PUNCT
iajs-2271	214	35	sso1930	sso1930	NOUN
iajs-2271	214	36	”	"	PUNCT
iajs-2271	214	37	)	)	PUNCT
iajs-2271	214	38	and	and	CCONJ
iajs-2271	214	39	(	(	PUNCT
iajs-2271	214	40	gdha-4	gdha-4	NOUN
iajs-2271	214	41	“	"	PUNCT
iajs-2271	214	42	sso2044	sso2044	NOUN
iajs-2271	214	43	”	"	PUNCT
iajs-2271	214	44	)	)	PUNCT
iajs-2271	214	45	.	.	PUNCT
iajs-2271	215	1	the	the	DET
iajs-2271	215	2	enzyme	enzyme	NOUN
iajs-2271	215	3	and	and	CCONJ
iajs-2271	215	4	the	the	DET
iajs-2271	215	5	genes	gene	NOUN
iajs-2271	215	6	were	be	AUX
iajs-2271	215	7	assigned	assign	VERB
iajs-2271	215	8	to	to	ADP
iajs-2271	215	9	ec	ec	PROPN
iajs-2271	215	10	1.4.1.4	1.4.1.4	PROPN
iajs-2271	215	11	in	in	ADP
iajs-2271	215	12	glutamate	glutamate	NOUN
iajs-2271	215	13	biosynthesis	biosynthesis	NOUN
iajs-2271	215	14	pathway	pathway	NOUN
iajs-2271	215	15	(	(	PUNCT
iajs-2271	215	16	supplementary	supplementary	ADJ
iajs-2271	215	17	figure	figure	NOUN
iajs-2271	215	18	5	5	NUM
iajs-2271	215	19	)	)	PUNCT
iajs-2271	215	20	.	.	PUNCT
iajs-2271	216	1	phosphoribosyl	phosphoribosyl	PROPN
iajs-2271	216	2	-	-	PUNCT
iajs-2271	216	3	atp	atp	PROPN
iajs-2271	216	4	diphosphatase	diphosphatase	NOUN
iajs-2271	216	5	(	(	PUNCT
iajs-2271	216	6	ec	ec	PROPN
iajs-2271	216	7	3.6.1.31	3.6.1.31	PROPN
iajs-2271	216	8	)	)	PUNCT
iajs-2271	216	9	in	in	ADP
iajs-2271	216	10	histidine	histidine	NOUN
iajs-2271	216	11	biosynthesis	biosynthesis	NOUN
iajs-2271	216	12	pathway	pathway	NOUN
iajs-2271	216	13	was	be	AUX
iajs-2271	216	14	already	already	ADV
iajs-2271	216	15	annotated	annotate	VERB
iajs-2271	216	16	in	in	ADP
iajs-2271	216	17	the	the	DET
iajs-2271	216	18	s.	s.	PROPN
iajs-2271	216	19	solfataricus	solfataricus	PROPN
iajs-2271	216	20	p2	p2	PROPN
iajs-2271	216	21	genome	genome	NOUN
iajs-2271	216	22	(	(	PUNCT
iajs-2271	216	23	hise	hise	NOUN
iajs-2271	216	24	“	"	PUNCT
iajs-2271	216	25	sso6223	sso6223	NOUN
iajs-2271	216	26	)	)	PUNCT
iajs-2271	216	27	.	.	PUNCT
iajs-2271	217	1	in	in	ADP
iajs-2271	217	2	s.	s.	PROPN
iajs-2271	217	3	solfataricus	solfataricus	VERB
iajs-2271	217	4	the	the	DET
iajs-2271	217	5	hisbpx	hisbpx	NOUN
iajs-2271	217	6	gene	gene	NOUN
iajs-2271	217	7	encoding	encode	VERB
iajs-2271	217	8	histidinol	histidinol	ADJ
iajs-2271	217	9	-	-	PUNCT
iajs-2271	217	10	phosphatase	phosphatase	NOUN
iajs-2271	217	11	(	(	PUNCT
iajs-2271	217	12	ec	ec	PROPN
iajs-2271	217	13	3.1.3.15	3.1.3.15	PROPN
iajs-2271	217	14	)	)	PUNCT
iajs-2271	217	15	is	be	AUX
iajs-2271	217	16	either	either	ADV
iajs-2271	217	17	located	locate	VERB
iajs-2271	217	18	at	at	ADP
iajs-2271	217	19	a	a	DET
iajs-2271	217	20	different	different	ADJ
iajs-2271	217	21	position	position	NOUN
iajs-2271	217	22	in	in	ADP
iajs-2271	217	23	the	the	DET
iajs-2271	217	24	genome	genome	NOUN
iajs-2271	217	25	,	,	PUNCT
iajs-2271	217	26	or	or	CCONJ
iajs-2271	217	27	it	it	PRON
iajs-2271	217	28	can	can	AUX
iajs-2271	217	29	not	not	PART
iajs-2271	217	30	be	be	AUX
iajs-2271	217	31	recognized	recognize	VERB
iajs-2271	217	32	due	due	ADP
iajs-2271	217	33	to	to	ADP
iajs-2271	217	34	lack	lack	NOUN
iajs-2271	217	35	of	of	ADP
iajs-2271	217	36	sufficient	sufficient	ADJ
iajs-2271	217	37	sequence	sequence	NOUN
iajs-2271	217	38	similarity	similarity	NOUN
iajs-2271	217	39	.	.	PUNCT
iajs-2271	218	1	the	the	DET
iajs-2271	218	2	only	only	ADJ
iajs-2271	218	3	candidate	candidate	NOUN
iajs-2271	218	4	orf	orf	PROPN
iajs-2271	218	5	in	in	ADP
iajs-2271	218	6	the	the	DET
iajs-2271	218	7	s.	s.	PROPN
iajs-2271	218	8	solfataricus	solfataricus	NOUN
iajs-2271	218	9	his	his	PRON
iajs-2271	218	10	operon	operon	NOUN
iajs-2271	218	11	is	be	AUX
iajs-2271	218	12	c0849	c0849	NOUN
iajs-2271	218	13	[	[	PUNCT
iajs-2271	218	14	36	36	NUM
iajs-2271	218	15	]	]	PUNCT
iajs-2271	218	16	.	.	PUNCT
iajs-2271	219	1	the	the	DET
iajs-2271	219	2	both	both	DET
iajs-2271	219	3	enzymes	enzyme	NOUN
iajs-2271	219	4	were	be	AUX
iajs-2271	219	5	assigned	assign	VERB
iajs-2271	219	6	to	to	ADP
iajs-2271	219	7	the	the	DET
iajs-2271	219	8	corresponding	correspond	VERB
iajs-2271	219	9	ec	ec	NOUN
iajs-2271	219	10	-	-	PUNCT
iajs-2271	219	11	numbers	number	NOUN
iajs-2271	219	12	in	in	ADP
iajs-2271	219	13	the	the	DET
iajs-2271	219	14	histidine	histidine	NOUN
iajs-2271	219	15	biosynthesis	biosynthesis	NOUN
iajs-2271	219	16	pathway	pathway	NOUN
iajs-2271	219	17	(	(	PUNCT
iajs-2271	219	18	supplementary	supplementary	ADJ
iajs-2271	219	19	figure	figure	NOUN
iajs-2271	219	20	6	6	NUM
iajs-2271	219	21	)	)	PUNCT
iajs-2271	219	22	.	.	PUNCT
iajs-2271	220	1	4	4	X
iajs-2271	220	2	.	.	X
iajs-2271	220	3	conclusions	conclusion	NOUN
iajs-2271	220	4	using	use	VERB
iajs-2271	220	5	the	the	DET
iajs-2271	220	6	annotated	annotate	VERB
iajs-2271	220	7	genome	genome	NOUN
iajs-2271	220	8	,	,	PUNCT
iajs-2271	220	9	automated	automate	VERB
iajs-2271	220	10	metabolic	metabolic	NOUN
iajs-2271	220	11	reconstruction	reconstruction	NOUN
iajs-2271	220	12	created	create	VERB
iajs-2271	220	13	the	the	DET
iajs-2271	220	14	pathway	pathway	NOUN
iajs-2271	220	15	/	/	SYM
iajs-2271	220	16	genome	genome	NOUN
iajs-2271	220	17	data	data	NOUN
iajs-2271	220	18	base	base	NOUN
iajs-2271	220	19	(	(	PUNCT
iajs-2271	220	20	pgdb	pgdb	NOUN
iajs-2271	220	21	)	)	PUNCT
iajs-2271	220	22	specific	specific	ADJ
iajs-2271	220	23	for	for	ADP
iajs-2271	220	24	sulfolobus	sulfolobus	ADJ
iajs-2271	220	25	solfataricus	solfataricus	NOUN
iajs-2271	220	26	.	.	PUNCT
iajs-2271	221	1	manual	manual	ADJ
iajs-2271	221	2	curation	curation	NOUN
iajs-2271	221	3	based	base	VERB
iajs-2271	221	4	on	on	ADP
iajs-2271	221	5	literature	literature	NOUN
iajs-2271	221	6	and	and	CCONJ
iajs-2271	221	7	protein	protein	NOUN
iajs-2271	221	8	function	function	NOUN
iajs-2271	221	9	prediction	prediction	NOUN
iajs-2271	221	10	methods	method	NOUN
iajs-2271	221	11	improved	improve	VERB
iajs-2271	221	12	the	the	DET
iajs-2271	221	13	pgdb	pgdb	NOUN
iajs-2271	221	14	and	and	CCONJ
iajs-2271	221	15	consequently	consequently	ADV
iajs-2271	221	16	with	with	ADP
iajs-2271	221	17	continuous	continuous	ADJ
iajs-2271	221	18	curation	curation	NOUN
iajs-2271	221	19	,	,	PUNCT
iajs-2271	221	20	the	the	DET
iajs-2271	221	21	genomic	genomic	ADJ
iajs-2271	221	22	annotations	annotation	NOUN
iajs-2271	221	23	can	can	AUX
iajs-2271	221	24	also	also	ADV
iajs-2271	221	25	be	be	AUX
iajs-2271	221	26	improved	improve	VERB
iajs-2271	221	27	.	.	PUNCT
iajs-2271	222	1	curation	curation	NOUN
iajs-2271	222	2	process	process	NOUN
iajs-2271	222	3	in	in	ADP
iajs-2271	222	4	the	the	DET
iajs-2271	222	5	current	current	ADJ
iajs-2271	222	6	study	study	NOUN
iajs-2271	222	7	focused	focus	VERB
iajs-2271	222	8	on	on	ADP
iajs-2271	222	9	a	a	DET
iajs-2271	222	10	part	part	NOUN
iajs-2271	222	11	of	of	ADP
iajs-2271	222	12	the	the	DET
iajs-2271	222	13	metabolic	metabolic	NOUN
iajs-2271	222	14	pathways	pathway	NOUN
iajs-2271	222	15	specific	specific	ADJ
iajs-2271	222	16	for	for	ADP
iajs-2271	222	17	amino	amino	ADJ
iajs-2271	222	18	acids	acid	NOUN
iajs-2271	222	19	biosynthesis	biosynthesis	NOUN
iajs-2271	222	20	.	.	PUNCT
iajs-2271	223	1	the	the	DET
iajs-2271	223	2	curation	curation	NOUN
iajs-2271	223	3	should	should	AUX
iajs-2271	223	4	expand	expand	VERB
iajs-2271	223	5	to	to	PART
iajs-2271	223	6	cover	cover	VERB
iajs-2271	223	7	the	the	DET
iajs-2271	223	8	other	other	ADJ
iajs-2271	223	9	metabolic	metabolic	NOUN
iajs-2271	223	10	pathways	pathway	NOUN
iajs-2271	223	11	especially	especially	ADV
iajs-2271	223	12	those	those	PRON
iajs-2271	223	13	which	which	PRON
iajs-2271	223	14	are	be	AUX
iajs-2271	223	15	considered	consider	VERB
iajs-2271	223	16	to	to	PART
iajs-2271	223	17	be	be	AUX
iajs-2271	223	18	essential	essential	ADJ
iajs-2271	223	19	for	for	ADP
iajs-2271	223	20	sulfolobus	sulfolobus	NOUN
iajs-2271	223	21	solfataricus	solfataricus	NOUN
iajs-2271	223	22	such	such	ADJ
iajs-2271	223	23	as	as	ADP
iajs-2271	223	24	sulfur	sulfur	NOUN
iajs-2271	223	25	metabolism	metabolism	NOUN
iajs-2271	223	26	pathways	pathway	NOUN
iajs-2271	223	27	.	.	PUNCT
iajs-2271	224	1	the	the	DET
iajs-2271	224	2	advantage	advantage	NOUN
iajs-2271	224	3	of	of	ADP
iajs-2271	224	4	using	use	VERB
iajs-2271	224	5	pathway	pathway	NOUN
iajs-2271	224	6	tools	tool	NOUN
iajs-2271	224	7	software	software	NOUN
iajs-2271	224	8	for	for	ADP
iajs-2271	224	9	automated	automate	VERB
iajs-2271	224	10	metabolic	metabolic	NOUN
iajs-2271	224	11	reconstruction	reconstruction	NOUN
iajs-2271	224	12	is	be	AUX
iajs-2271	224	13	the	the	DET
iajs-2271	224	14	bird	bird	NOUN
iajs-2271	224	15	's	's	PART
iajs-2271	224	16	eye	eye	NOUN
iajs-2271	224	17	view	view	NOUN
iajs-2271	224	18	of	of	ADP
iajs-2271	224	19	the	the	DET
iajs-2271	224	20	created	create	VERB
iajs-2271	224	21	data	data	NOUN
iajs-2271	224	22	base	base	NOUN
iajs-2271	224	23	components	component	NOUN
iajs-2271	224	24	.	.	PUNCT
iajs-2271	225	1	the	the	DET
iajs-2271	225	2	object	object	NOUN
iajs-2271	225	3	-	-	PUNCT
iajs-2271	225	4	oriented	orient	VERB
iajs-2271	225	5	nature	nature	NOUN
iajs-2271	225	6	of	of	ADP
iajs-2271	225	7	these	these	DET
iajs-2271	225	8	(	(	PUNCT
iajs-2271	225	9	pgdbs	pgdbs	NOUN
iajs-2271	225	10	)	)	PUNCT
iajs-2271	225	11	enables	enable	VERB
iajs-2271	225	12	the	the	DET
iajs-2271	225	13	users	user	NOUN
iajs-2271	225	14	to	to	PART
iajs-2271	225	15	easily	easily	ADV
iajs-2271	225	16	visualize	visualize	VERB
iajs-2271	225	17	the	the	DET
iajs-2271	225	18	pathways	pathway	NOUN
iajs-2271	225	19	and	and	CCONJ
iajs-2271	225	20	get	get	VERB
iajs-2271	225	21	detailed	detailed	ADJ
iajs-2271	225	22	information	information	NOUN
iajs-2271	225	23	over	over	ADP
iajs-2271	225	24	the	the	DET
iajs-2271	225	25	reactions	reaction	NOUN
iajs-2271	225	26	,	,	PUNCT
iajs-2271	225	27	cofactors	cofactor	NOUN
iajs-2271	225	28	,	,	PUNCT
iajs-2271	225	29	genes	gene	NOUN
iajs-2271	225	30	and	and	CCONJ
iajs-2271	225	31	the	the	DET
iajs-2271	225	32	encoding	encoding	NOUN
iajs-2271	225	33	proteins	protein	NOUN
iajs-2271	225	34	and	and	CCONJ
iajs-2271	225	35	even	even	ADV
iajs-2271	225	36	the	the	DET
iajs-2271	225	37	chemical	chemical	NOUN
iajs-2271	225	38	structures	structure	NOUN
iajs-2271	225	39	of	of	ADP
iajs-2271	225	40	all	all	DET
iajs-2271	225	41	intermediates	intermediate	NOUN
iajs-2271	225	42	.	.	PUNCT
iajs-2271	226	1	the	the	DET
iajs-2271	226	2	complete	complete	ADJ
iajs-2271	226	3	curation	curation	NOUN
iajs-2271	226	4	of	of	ADP
iajs-2271	226	5	the	the	DET
iajs-2271	226	6	sulfolobus	sulfolobus	ADJ
iajs-2271	226	7	solfataricus	solfataricus	ADJ
iajs-2271	226	8	pgdb	pgdb	NOUN
iajs-2271	226	9	should	should	AUX
iajs-2271	226	10	include	include	VERB
iajs-2271	226	11	detailed	detailed	ADJ
iajs-2271	226	12	refining	refining	NOUN
iajs-2271	226	13	by	by	ADP
iajs-2271	226	14	removing	remove	VERB
iajs-2271	226	15	non	non	ADJ
iajs-2271	226	16	-	-	ADJ
iajs-2271	226	17	existing	existing	ADJ
iajs-2271	226	18	pathways	pathway	NOUN
iajs-2271	226	19	that	that	PRON
iajs-2271	226	20	have	have	AUX
iajs-2271	226	21	been	be	AUX
iajs-2271	226	22	false	false	ADV
iajs-2271	226	23	-	-	PUNCT
iajs-2271	226	24	detected	detect	VERB
iajs-2271	226	25	by	by	ADP
iajs-2271	226	26	the	the	DET
iajs-2271	226	27	pathologic	pathologic	NOUN
iajs-2271	226	28	.	.	PUNCT
iajs-2271	227	1	more	more	ADV
iajs-2271	227	2	detailed	detailed	ADJ
iajs-2271	227	3	and	and	CCONJ
iajs-2271	227	4	complete	complete	ADJ
iajs-2271	227	5	annotations	annotation	NOUN
iajs-2271	227	6	and	and	CCONJ
iajs-2271	227	7	citations	citation	NOUN
iajs-2271	227	8	should	should	AUX
iajs-2271	227	9	be	be	AUX
iajs-2271	227	10	added	add	VERB
iajs-2271	227	11	to	to	PART
iajs-2271	227	12	get	get	VERB
iajs-2271	227	13	as	as	ADP
iajs-2271	227	14	a	a	DET
iajs-2271	227	15	complete	complete	ADJ
iajs-2271	227	16	pgdb	pgdb	NOUN
iajs-2271	227	17	as	as	ADP
iajs-2271	227	18	possible	possible	ADJ
iajs-2271	227	19	.	.	PUNCT
iajs-2271	228	1	a	a	DET
iajs-2271	228	2	complete	complete	ADV
iajs-2271	228	3	-	-	PUNCT
iajs-2271	228	4	curated	curate	VERB
iajs-2271	228	5	sulfolobus	sulfolobus	NOUN
iajs-2271	228	6	solfataricus	solfataricus	ADJ
iajs-2271	228	7	pgdb	pgdb	NOUN
iajs-2271	228	8	same	same	ADJ
iajs-2271	228	9	as	as	ADP
iajs-2271	228	10	the	the	DET
iajs-2271	228	11	other	other	ADJ
iajs-2271	228	12	good	good	ADJ
iajs-2271	228	13	curated	curate	VERB
iajs-2271	228	14	pgdbs	pgdbs	NOUN
iajs-2271	228	15	can	can	AUX
iajs-2271	228	16	serve	serve	VERB
iajs-2271	228	17	as	as	ADP
iajs-2271	228	18	a	a	DET
iajs-2271	228	19	reference	reference	NOUN
iajs-2271	228	20	knowledge	knowledge	NOUN
iajs-2271	228	21	base	base	NOUN
iajs-2271	228	22	for	for	ADP
iajs-2271	228	23	genomic	genomic	ADJ
iajs-2271	228	24	annotations	annotation	NOUN
iajs-2271	228	25	and	and	CCONJ
iajs-2271	228	26	metabolic	metabolic	NOUN
iajs-2271	228	27	reconstructions	reconstruction	NOUN
iajs-2271	228	28	for	for	ADP
iajs-2271	228	29	other	other	ADJ
iajs-2271	228	30	organisms	organism	NOUN
iajs-2271	228	31	especially	especially	ADV
iajs-2271	228	32	the	the	DET
iajs-2271	228	33	closely	closely	ADV
iajs-2271	228	34	related	relate	VERB
iajs-2271	228	35	archaea	archaea	NOUN
iajs-2271	228	36	.	.	PUNCT
iajs-2271	229	1	acknowledgments	acknowledgment	NOUN
iajs-2271	229	2	i	i	PRON
iajs-2271	229	3	would	would	AUX
iajs-2271	229	4	like	like	VERB
iajs-2271	229	5	to	to	PART
iajs-2271	229	6	thank	thank	VERB
iajs-2271	229	7	dr	dr	PROPN
iajs-2271	229	8	harmen	harmen	PROPN
iajs-2271	229	9	van	van	PROPN
iajs-2271	229	10	de	de	X
iajs-2271	229	11	werken	werken	PROPN
iajs-2271	229	12	for	for	ADP
iajs-2271	229	13	his	his	PRON
iajs-2271	229	14	valuable	valuable	ADJ
iajs-2271	229	15	advices	advice	NOUN
iajs-2271	229	16	during	during	ADP
iajs-2271	229	17	the	the	DET
iajs-2271	229	18	implementation	implementation	NOUN
iajs-2271	229	19	of	of	ADP
iajs-2271	229	20	this	this	DET
iajs-2271	229	21	work	work	NOUN
iajs-2271	229	22	.	.	PUNCT
iajs-2271	230	1	thanks	thank	NOUN
iajs-2271	230	2	also	also	ADV
iajs-2271	230	3	to	to	ADP
iajs-2271	230	4	dr	dr	PROPN
iajs-2271	230	5	frank	frank	PROPN
iajs-2271	230	6	h.	h.	PROPN
iajs-2271	230	7	j.	j.	PROPN
iajs-2271	230	8	van	van	PROPN
iajs-2271	230	9	enckevort	enckevort	PROPN
iajs-2271	230	10	,	,	PUNCT
iajs-2271	230	11	who	who	PRON
iajs-2271	230	12	created	create	VERB
iajs-2271	230	13	the	the	DET
iajs-2271	230	14	initial	initial	ADJ
iajs-2271	230	15	pgdb	pgdb	NOUN
iajs-2271	230	16	for	for	ADP
iajs-2271	230	17	sulfolobus	sulfolobus	NOUN
iajs-2271	230	18	solfataricus	solfataricus	ADJ
iajs-2271	230	19	p2	p2	NOUN
iajs-2271	230	20	.	.	PUNCT
iajs-2271	231	1	also	also	ADV
iajs-2271	231	2	the	the	DET
iajs-2271	231	3	author	author	NOUN
iajs-2271	231	4	would	would	AUX
iajs-2271	231	5	like	like	VERB
iajs-2271	231	6	to	to	PART
iajs-2271	231	7	thank	thank	VERB
iajs-2271	231	8	and	and	CCONJ
iajs-2271	231	9	appreciate	appreciate	VERB
iajs-2271	231	10	the	the	DET
iajs-2271	231	11	great	great	ADJ
iajs-2271	231	12	support	support	NOUN
iajs-2271	231	13	from	from	ADP
iajs-2271	231	14	professor	professor	PROPN
iajs-2271	231	15	john	john	PROPN
iajs-2271	231	16	van	van	PROPN
iajs-2271	231	17	der	der	PROPN
iajs-2271	231	18	oost	oost	PROPN
iajs-2271	231	19	.	.	PUNCT
iajs-2271	232	1	16	16	NUM
iajs-2271	232	2	ibn	ibn	PROPN
iajs-2271	232	3	al	al	PROPN
iajs-2271	232	4	-	-	PUNCT
iajs-2271	232	5	haitham	haitham	PROPN
iajs-2271	232	6	jour	jour	X
iajs-2271	232	7	.	.	PROPN
iajs-2271	232	8	for	for	ADP
iajs-2271	232	9	pure	pure	ADJ
iajs-2271	232	10	&	&	CCONJ
iajs-2271	232	11	appl	appl	PROPN
iajs-2271	232	12	.	.	PUNCT
iajs-2271	233	1	sci	sci	PROPN
iajs-2271	233	2	.	.	PROPN
iajs-2271	233	3	32	32	NUM
iajs-2271	233	4	(	(	PUNCT
iajs-2271	233	5	3	3	NUM
iajs-2271	233	6	)	)	SYM
iajs-2271	233	7	2019	2019	NUM
iajs-2271	233	8	references	reference	NOUN
iajs-2271	233	9	1	1	NUM
iajs-2271	233	10	.	.	PUNCT
iajs-2271	233	11	keeling	keeling	PROPN
iajs-2271	233	12	,	,	PUNCT
iajs-2271	233	13	p.j	p.j	PROPN
iajs-2271	233	14	.	.	PROPN
iajs-2271	233	15	;	;	PUNCT
iajs-2271	233	16	charlebois	charlebois	PROPN
iajs-2271	233	17	,	,	PUNCT
iajs-2271	233	18	r.l	r.l	PROPN
iajs-2271	233	19	.	.	PROPN
iajs-2271	233	20	;	;	PUNCT
iajs-2271	233	21	doolittle	doolittle	PROPN
iajs-2271	233	22	,	,	PUNCT
iajs-2271	233	23	w.f	w.f	PROPN
iajs-2271	233	24	.	.	PROPN
iajs-2271	233	25	archaebacterial	archaebacterial	ADJ
iajs-2271	233	26	genomes	genome	NOUN
iajs-2271	233	27	:	:	PUNCT
iajs-2271	233	28	eubacterial	eubacterial	ADJ
iajs-2271	233	29	form	form	NOUN
iajs-2271	233	30	and	and	CCONJ
iajs-2271	233	31	eukaryotic	eukaryotic	ADJ
iajs-2271	233	32	content	content	NOUN
iajs-2271	233	33	.	.	PUNCT
iajs-2271	234	1	curr	curr	PROPN
iajs-2271	234	2	opin	opin	PROPN
iajs-2271	234	3	genet	genet	NOUN
iajs-2271	234	4	dev.1994	dev.1994	ADP
iajs-2271	234	5	,	,	PUNCT
iajs-2271	234	6	4	4	NUM
iajs-2271	234	7	,	,	PUNCT
iajs-2271	234	8	816	816	NUM
iajs-2271	234	9	-	-	SYM
iajs-2271	234	10	22	22	NUM
iajs-2271	234	11	,	,	PUNCT
iajs-2271	234	12	url	url	NOUN
iajs-2271	234	13	:	:	PUNCT
iajs-2271	234	14	http://www.ncbi.nlm.nih.gov/pubmed/7888750	http://www.ncbi.nlm.nih.gov/pubmed/7888750	NUM
iajs-2271	234	15	.	.	NOUN
iajs-2271	235	1	2	2	X
iajs-2271	235	2	.	.	X
iajs-2271	235	3	grabowski	grabowski	PROPN
iajs-2271	235	4	,	,	PUNCT
iajs-2271	235	5	b.	b.	PROPN
iajs-2271	235	6	;	;	PUNCT
iajs-2271	235	7	kelman	kelman	PROPN
iajs-2271	235	8	,	,	PUNCT
iajs-2271	235	9	z.	z.	PROPN
iajs-2271	235	10	archeal	archeal	PROPN
iajs-2271	235	11	dna	dna	PROPN
iajs-2271	235	12	replication	replication	NOUN
iajs-2271	235	13	:	:	PUNCT
iajs-2271	235	14	eukaryal	eukaryal	ADJ
iajs-2271	235	15	proteins	protein	NOUN
iajs-2271	235	16	in	in	ADP
iajs-2271	235	17	a	a	DET
iajs-2271	235	18	bacterial	bacterial	ADJ
iajs-2271	235	19	context	context	NOUN
iajs-2271	235	20	.	.	PUNCT
iajs-2271	236	1	annu	annu	PROPN
iajs-2271	236	2	rev	rev	VERB
iajs-2271	236	3	microbiol	microbiol	PROPN
iajs-2271	236	4	.	.	PUNCT
iajs-2271	237	1	2003	2003	NUM
iajs-2271	237	2	,	,	PUNCT
iajs-2271	237	3	57	57	NUM
iajs-2271	237	4	,	,	PUNCT
iajs-2271	237	5	487	487	NUM
iajs-2271	237	6	-	-	SYM
iajs-2271	237	7	516	516	NUM
iajs-2271	237	8	,	,	PUNCT
iajs-2271	237	9	doi	doi	NOUN
iajs-2271	237	10	:	:	PUNCT
iajs-2271	237	11	10.1146	10.1146	NUM
iajs-2271	237	12	/	/	SYM
iajs-2271	237	13	annurev.micro.57.030502.090709	annurev.micro.57.030502.090709	PROPN
iajs-2271	237	14	.	.	PUNCT
iajs-2271	238	1	3	3	X
iajs-2271	238	2	.	.	X
iajs-2271	239	1	she	she	PRON
iajs-2271	239	2	,	,	PUNCT
iajs-2271	239	3	q.	q.	PROPN
iajs-2271	239	4	;	;	PUNCT
iajs-2271	239	5	singh	singh	PROPN
iajs-2271	239	6	,	,	PUNCT
iajs-2271	239	7	r.k	r.k	PROPN
iajs-2271	239	8	.	.	PROPN
iajs-2271	239	9	;	;	PUNCT
iajs-2271	239	10	confalonieri	confalonieri	PROPN
iajs-2271	239	11	,	,	PUNCT
iajs-2271	239	12	f.	f.	PROPN
iajs-2271	239	13	;	;	PUNCT
iajs-2271	239	14	zivanovic	zivanovic	PROPN
iajs-2271	239	15	,	,	PUNCT
iajs-2271	239	16	y.	y.	PROPN
iajs-2271	239	17	;	;	PUNCT
iajs-2271	239	18	allard	allard	PROPN
iajs-2271	239	19	,	,	PUNCT
iajs-2271	239	20	g.	g.	PROPN
iajs-2271	239	21	;	;	PUNCT
iajs-2271	239	22	et	et	PROPN
iajs-2271	239	23	al	al	PROPN
iajs-2271	239	24	.	.	PUNCT
iajs-2271	240	1	the	the	DET
iajs-2271	240	2	complete	complete	ADJ
iajs-2271	240	3	genome	genome	NOUN
iajs-2271	240	4	of	of	ADP
iajs-2271	240	5	the	the	DET
iajs-2271	240	6	crenarchaeon	crenarchaeon	PROPN
iajs-2271	240	7	sulfolobus	sulfolobus	PROPN
iajs-2271	240	8	solfataricus	solfataricus	ADJ
iajs-2271	240	9	p2	p2	NOUN
iajs-2271	240	10	.	.	PUNCT
iajs-2271	241	1	proc	proc	PROPN
iajs-2271	241	2	natl	natl	PROPN
iajs-2271	241	3	acad	acad	PROPN
iajs-2271	241	4	sci	sci	PROPN
iajs-2271	241	5	u	u	PROPN
iajs-2271	241	6	s	s	NOUN
iajs-2271	241	7	a.	a.	NOUN
iajs-2271	241	8	2001	2001	NUM
iajs-2271	241	9	,	,	PUNCT
iajs-2271	241	10	98	98	NUM
iajs-2271	241	11	,	,	PUNCT
iajs-2271	241	12	7835	7835	NUM
iajs-2271	241	13	-	-	SYM
iajs-2271	241	14	40	40	NUM
iajs-2271	241	15	,	,	PUNCT
iajs-2271	241	16	doi	doi	NOUN
iajs-2271	241	17	:	:	PUNCT
iajs-2271	241	18	10.1073	10.1073	NUM
iajs-2271	241	19	/	/	SYM
iajs-2271	241	20	pnas.141222098	pnas.141222098	PROPN
iajs-2271	241	21	.	.	PROPN
iajs-2271	241	22	4	4	X
iajs-2271	241	23	.	.	PUNCT
iajs-2271	242	1	verhees	verhee	NOUN
iajs-2271	242	2	,	,	PUNCT
iajs-2271	242	3	c.h	c.h	PROPN
iajs-2271	242	4	.	.	PROPN
iajs-2271	242	5	;	;	PUNCT
iajs-2271	242	6	kengen	kengen	PROPN
iajs-2271	242	7	,	,	PUNCT
iajs-2271	242	8	s.w	s.w	PROPN
iajs-2271	242	9	.	.	PROPN
iajs-2271	242	10	;	;	PUNCT
iajs-2271	242	11	tuininga	tuininga	PROPN
iajs-2271	242	12	,	,	PUNCT
iajs-2271	242	13	j.e	j.e	PROPN
iajs-2271	242	14	.	.	PROPN
iajs-2271	242	15	;	;	PUNCT
iajs-2271	242	16	schut	schut	PROPN
iajs-2271	242	17	,	,	PUNCT
iajs-2271	242	18	g.j	g.j	PROPN
iajs-2271	242	19	.	.	PROPN
iajs-2271	242	20	;	;	PUNCT
iajs-2271	242	21	adams	adams	PROPN
iajs-2271	242	22	,	,	PUNCT
iajs-2271	242	23	m.w	m.w	PROPN
iajs-2271	242	24	.	.	PROPN
iajs-2271	242	25	;	;	PUNCT
iajs-2271	242	26	et	et	PROPN
iajs-2271	242	27	al	al	PROPN
iajs-2271	242	28	.	.	PUNCT
iajs-2271	243	1	the	the	DET
iajs-2271	243	2	unique	unique	ADJ
iajs-2271	243	3	features	feature	NOUN
iajs-2271	243	4	of	of	ADP
iajs-2271	243	5	glycolytic	glycolytic	ADJ
iajs-2271	243	6	pathways	pathway	NOUN
iajs-2271	243	7	in	in	ADP
iajs-2271	243	8	archaea	archaea	PROPN
iajs-2271	243	9	.	.	PUNCT
iajs-2271	244	1	biochem	biochem	PROPN
iajs-2271	244	2	j.	j.	PROPN
iajs-2271	244	3	2003	2003	NUM
iajs-2271	244	4	,	,	PUNCT
iajs-2271	244	5	375	375	NUM
iajs-2271	244	6	,	,	PUNCT
iajs-2271	244	7	231	231	NUM
iajs-2271	244	8	-	-	SYM
iajs-2271	244	9	46	46	NUM
iajs-2271	244	10	,	,	PUNCT
iajs-2271	244	11	doi	doi	NOUN
iajs-2271	244	12	:	:	PUNCT
iajs-2271	244	13	10.1042	10.1042	NUM
iajs-2271	244	14	/	/	SYM
iajs-2271	244	15	bj20021472	bj20021472	NOUN
iajs-2271	244	16	.	.	PUNCT
iajs-2271	245	1	5	5	X
iajs-2271	245	2	.	.	X
iajs-2271	245	3	karp	karp	PROPN
iajs-2271	245	4	,	,	PUNCT
iajs-2271	245	5	p.d	p.d	PROPN
iajs-2271	245	6	.	.	PROPN
iajs-2271	245	7	;	;	PUNCT
iajs-2271	245	8	paley	paley	PROPN
iajs-2271	245	9	,	,	PUNCT
iajs-2271	245	10	s.m	s.m	PROPN
iajs-2271	245	11	.	.	PROPN
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iajs-2271	245	13	of	of	ADP
iajs-2271	245	14	metabolic	metabolic	NOUN
iajs-2271	245	15	knowledge	knowledge	NOUN
iajs-2271	245	16	:	:	PUNCT
iajs-2271	245	17	pathways	pathway	NOUN
iajs-2271	245	18	.	.	PUNCT
iajs-2271	246	1	proc	proc	NOUN
iajs-2271	246	2	int	int	PROPN
iajs-2271	246	3	conf	conf	PROPN
iajs-2271	246	4	intell	intell	PROPN
iajs-2271	246	5	syst	syst	PROPN
iajs-2271	246	6	mol	mol	ADP
iajs-2271	246	7	biol	biol	PROPN
iajs-2271	246	8	.	.	PUNCT
iajs-2271	247	1	1994	1994	NUM
iajs-2271	247	2	,	,	PUNCT
iajs-2271	247	3	2	2	NUM
iajs-2271	247	4	,	,	PUNCT
iajs-2271	247	5	203	203	NUM
iajs-2271	247	6	-	-	SYM
iajs-2271	247	7	11	11	NUM
iajs-2271	247	8	,	,	PUNCT
iajs-2271	247	9	url	url	NOUN
iajs-2271	247	10	:	:	PUNCT
iajs-2271	247	11	http://www.ncbi.nlm.nih.gov/pubmed/7584392	http://www.ncbi.nlm.nih.gov/pubmed/7584392	NUM
iajs-2271	247	12	.	.	NOUN
iajs-2271	247	13	6	6	NUM
iajs-2271	247	14	.	.	X
iajs-2271	248	1	caspi	caspi	PROPN
iajs-2271	248	2	,	,	PUNCT
iajs-2271	248	3	r.	r.	PROPN
iajs-2271	248	4	;	;	PUNCT
iajs-2271	248	5	billington	billington	PROPN
iajs-2271	248	6	,	,	PUNCT
iajs-2271	248	7	r.	r.	PROPN
iajs-2271	248	8	;	;	PUNCT
iajs-2271	248	9	ferrer	ferrer	PROPN
iajs-2271	248	10	,	,	PUNCT
iajs-2271	248	11	l.	l.	PROPN
iajs-2271	248	12	;	;	PUNCT
iajs-2271	248	13	foerster	foerster	PROPN
iajs-2271	248	14	,	,	PUNCT
iajs-2271	248	15	h.	h.	PROPN
iajs-2271	248	16	;	;	PUNCT
iajs-2271	248	17	fulcher	fulcher	PROPN
iajs-2271	248	18	,	,	PUNCT
iajs-2271	248	19	c.a	c.a	PROPN
iajs-2271	248	20	.	.	PROPN
iajs-2271	248	21	;	;	PUNCT
iajs-2271	248	22	et	et	PROPN
iajs-2271	248	23	al	al	PROPN
iajs-2271	248	24	.	.	PUNCT
iajs-2271	249	1	the	the	DET
iajs-2271	249	2	metacyc	metacyc	NOUN
iajs-2271	249	3	database	database	NOUN
iajs-2271	249	4	of	of	ADP
iajs-2271	249	5	metabolic	metabolic	NOUN
iajs-2271	249	6	pathways	pathway	NOUN
iajs-2271	249	7	and	and	CCONJ
iajs-2271	249	8	enzymes	enzyme	NOUN
iajs-2271	249	9	and	and	CCONJ
iajs-2271	249	10	the	the	DET
iajs-2271	249	11	biocyc	biocyc	NOUN
iajs-2271	249	12	collection	collection	NOUN
iajs-2271	249	13	of	of	ADP
iajs-2271	249	14	pathway	pathway	NOUN
iajs-2271	249	15	/	/	SYM
iajs-2271	249	16	genome	genome	NOUN
iajs-2271	249	17	databases	database	NOUN
iajs-2271	249	18	.	.	PUNCT
iajs-2271	250	1	nucleic	nucleic	ADJ
iajs-2271	250	2	acids	acid	NOUN
iajs-2271	250	3	res.2016	res.2016	NUM
iajs-2271	250	4	,	,	PUNCT
iajs-2271	250	5	44	44	NUM
iajs-2271	250	6	,	,	PUNCT
iajs-2271	250	7	471	471	NUM
iajs-2271	250	8	-	-	SYM
iajs-2271	250	9	80	80	NUM
iajs-2271	250	10	,	,	PUNCT
iajs-2271	250	11	doi	doi	NOUN
iajs-2271	250	12	:	:	PUNCT
iajs-2271	250	13	10.1093	10.1093	NUM
iajs-2271	250	14	/	/	SYM
iajs-2271	250	15	nar	nar	NOUN
iajs-2271	250	16	/	/	SYM
iajs-2271	250	17	gkv1164	gkv1164	NOUN
iajs-2271	250	18	.	.	PUNCT
iajs-2271	251	1	7	7	X
iajs-2271	251	2	.	.	X
iajs-2271	251	3	caspi	caspi	PROPN
iajs-2271	251	4	,	,	PUNCT
iajs-2271	251	5	r.	r.	PROPN
iajs-2271	251	6	;	;	PUNCT
iajs-2271	251	7	billington	billington	PROPN
iajs-2271	251	8	,	,	PUNCT
iajs-2271	251	9	r.	r.	PROPN
iajs-2271	251	10	;	;	PUNCT
iajs-2271	251	11	fulcher	fulcher	PROPN
iajs-2271	251	12	,	,	PUNCT
iajs-2271	251	13	c.a	c.a	PROPN
iajs-2271	251	14	.	.	PROPN
iajs-2271	251	15	;	;	PUNCT
iajs-2271	251	16	keseler	keseler	ADJ
iajs-2271	251	17	,	,	PUNCT
iajs-2271	251	18	i.m	i.m	PROPN
iajs-2271	251	19	.	.	PROPN
iajs-2271	251	20	;	;	PUNCT
iajs-2271	251	21	kothari	kothari	PROPN
iajs-2271	251	22	,	,	PUNCT
iajs-2271	251	23	a.	a.	NOUN
iajs-2271	251	24	;	;	PUNCT
iajs-2271	251	25	et	et	PROPN
iajs-2271	251	26	al	al	PROPN
iajs-2271	251	27	.	.	PUNCT
iajs-2271	252	1	the	the	DET
iajs-2271	252	2	metacyc	metacyc	NOUN
iajs-2271	252	3	database	database	NOUN
iajs-2271	252	4	of	of	ADP
iajs-2271	252	5	metabolic	metabolic	NOUN
iajs-2271	252	6	pathways	pathway	NOUN
iajs-2271	252	7	and	and	CCONJ
iajs-2271	252	8	enzymes	enzyme	NOUN
iajs-2271	252	9	.	.	PUNCT
iajs-2271	253	1	nucleic	nucleic	ADJ
iajs-2271	253	2	acids	acid	NOUN
iajs-2271	253	3	res.2018	res.2018	NOUN
iajs-2271	253	4	,	,	PUNCT
iajs-2271	253	5	46	46	NUM
iajs-2271	253	6	,	,	PUNCT
iajs-2271	253	7	633	633	NUM
iajs-2271	253	8	-	-	SYM
iajs-2271	253	9	9	9	NUM
iajs-2271	253	10	,	,	PUNCT
iajs-2271	253	11	doi	doi	NOUN
iajs-2271	253	12	:	:	PUNCT
iajs-2271	253	13	10.1093	10.1093	NUM
iajs-2271	253	14	/	/	SYM
iajs-2271	253	15	nar	nar	NOUN
iajs-2271	253	16	/	/	SYM
iajs-2271	253	17	gkx935	gkx935	NOUN
iajs-2271	253	18	.	.	PUNCT
iajs-2271	254	1	8	8	NUM
iajs-2271	254	2	.	.	PUNCT
iajs-2271	255	1	karp	karp	PROPN
iajs-2271	255	2	,	,	PUNCT
iajs-2271	255	3	p.d	p.d	PROPN
iajs-2271	255	4	.	.	PROPN
iajs-2271	255	5	;	;	PUNCT
iajs-2271	255	6	paley	paley	PROPN
iajs-2271	255	7	,	,	PUNCT
iajs-2271	255	8	s.	s.	PROPN
iajs-2271	255	9	;	;	PUNCT
iajs-2271	255	10	altman	altman	PROPN
iajs-2271	255	11	,	,	PUNCT
iajs-2271	255	12	t.	t.	PROPN
iajs-2271	255	13	data	data	PROPN
iajs-2271	255	14	mining	mining	NOUN
iajs-2271	255	15	in	in	ADP
iajs-2271	255	16	the	the	DET
iajs-2271	255	17	metacyc	metacyc	NOUN
iajs-2271	255	18	family	family	NOUN
iajs-2271	255	19	of	of	ADP
iajs-2271	255	20	pathway	pathway	NOUN
iajs-2271	255	21	databases	database	NOUN
iajs-2271	255	22	.	.	PUNCT
iajs-2271	256	1	methods	method	NOUN
iajs-2271	256	2	mol	mol	ADP
iajs-2271	256	3	biol.2013	biol.2013	NOUN
iajs-2271	256	4	,	,	PUNCT
iajs-2271	256	5	939	939	NUM
iajs-2271	256	6	,	,	PUNCT
iajs-2271	256	7	183	183	NUM
iajs-2271	256	8	-	-	SYM
iajs-2271	256	9	200	200	NUM
iajs-2271	256	10	,	,	PUNCT
iajs-2271	256	11	doi	doi	NOUN
iajs-2271	256	12	:	:	PUNCT
iajs-2271	256	13	10.1007/978	10.1007/978	NUM
iajs-2271	256	14	-	-	SYM
iajs-2271	256	15	1	1	NUM
iajs-2271	256	16	-	-	PUNCT
iajs-2271	256	17	62703	62703	NUM
iajs-2271	256	18	-	-	SYM
iajs-2271	256	19	107	107	NUM
iajs-2271	256	20	-	-	SYM
iajs-2271	256	21	3_12	3_12	NUM
iajs-2271	256	22	.	.	PUNCT
iajs-2271	257	1	9	9	NUM
iajs-2271	257	2	.	.	X
iajs-2271	257	3	karp	karp	PROPN
iajs-2271	257	4	,	,	PUNCT
iajs-2271	257	5	p.d	p.d	PROPN
iajs-2271	257	6	.	.	PROPN
iajs-2271	257	7	;	;	PUNCT
iajs-2271	257	8	riley	riley	PROPN
iajs-2271	257	9	,	,	PUNCT
iajs-2271	257	10	m.	m.	NOUN
iajs-2271	257	11	;	;	PUNCT
iajs-2271	257	12	paley	paley	PROPN
iajs-2271	257	13	,	,	PUNCT
iajs-2271	257	14	s.m	s.m	PROPN
iajs-2271	257	15	.	.	PROPN
iajs-2271	257	16	;	;	PUNCT
iajs-2271	257	17	pellegrini	pellegrini	PROPN
iajs-2271	257	18	-	-	PUNCT
iajs-2271	257	19	toole	toole	PROPN
iajs-2271	257	20	,	,	PUNCT
iajs-2271	257	21	a.	a.	NOUN
iajs-2271	257	22	the	the	DET
iajs-2271	257	23	metacyc	metacyc	NOUN
iajs-2271	257	24	database	database	NOUN
iajs-2271	257	25	.	.	PUNCT
iajs-2271	258	1	nucleic	nucleic	ADJ
iajs-2271	258	2	acids	acid	NOUN
iajs-2271	258	3	res.2002	res.2002	ADP
iajs-2271	258	4	,	,	PUNCT
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iajs-2271	258	6	,	,	PUNCT
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iajs-2271	258	8	-	-	SYM
iajs-2271	258	9	61	61	NUM
iajs-2271	258	10	,	,	PUNCT
iajs-2271	258	11	url	url	NOUN
iajs-2271	258	12	:	:	PUNCT
iajs-2271	258	13	http://www.ncbi.nlm.nih.gov/pubmed/11752254	http://www.ncbi.nlm.nih.gov/pubmed/11752254	NUM
iajs-2271	258	14	.	.	PUNCT
iajs-2271	259	1	10	10	NUM
iajs-2271	259	2	.	.	PUNCT
iajs-2271	260	1	karp	karp	PROPN
iajs-2271	260	2	,	,	PUNCT
iajs-2271	260	3	p.d	p.d	PROPN
iajs-2271	260	4	.	.	PROPN
iajs-2271	260	5	;	;	PUNCT
iajs-2271	260	6	latendresse	latendresse	PROPN
iajs-2271	260	7	,	,	PUNCT
iajs-2271	260	8	m.	m.	NOUN
iajs-2271	260	9	;	;	PUNCT
iajs-2271	260	10	paley	paley	PROPN
iajs-2271	260	11	,	,	PUNCT
iajs-2271	260	12	s.m	s.m	PROPN
iajs-2271	260	13	.	.	PROPN
iajs-2271	260	14	;	;	PUNCT
iajs-2271	260	15	krummenacker	krummenacker	PROPN
iajs-2271	260	16	,	,	PUNCT
iajs-2271	260	17	m.	m.	NOUN
iajs-2271	260	18	;	;	PUNCT
iajs-2271	260	19	ong	ong	PROPN
iajs-2271	260	20	,	,	PUNCT
iajs-2271	260	21	q.d	q.d	PROPN
iajs-2271	260	22	.	.	PROPN
iajs-2271	260	23	;	;	PUNCT
iajs-2271	260	24	et	et	PROPN
iajs-2271	260	25	al	al	PROPN
iajs-2271	260	26	.	.	PUNCT
iajs-2271	260	27	pathway	pathway	NOUN
iajs-2271	260	28	tools	tool	NOUN
iajs-2271	260	29	version	version	VERB
iajs-2271	260	30	19.0	19.0	NUM
iajs-2271	260	31	update	update	NOUN
iajs-2271	260	32	:	:	PUNCT
iajs-2271	260	33	software	software	NOUN
iajs-2271	260	34	for	for	ADP
iajs-2271	260	35	pathway	pathway	NOUN
iajs-2271	260	36	/	/	SYM
iajs-2271	260	37	genome	genome	NOUN
iajs-2271	260	38	informatics	informatic	NOUN
iajs-2271	260	39	and	and	CCONJ
iajs-2271	260	40	systems	system	NOUN
iajs-2271	260	41	biology	biology	NOUN
iajs-2271	260	42	.	.	PUNCT
iajs-2271	261	1	brief	brief	ADJ
iajs-2271	261	2	bioinform	bioinform	NOUN
iajs-2271	261	3	.	.	PUNCT
iajs-2271	262	1	2016	2016	NUM
iajs-2271	262	2	,	,	PUNCT
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iajs-2271	262	4	,	,	PUNCT
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iajs-2271	262	6	-	-	SYM
iajs-2271	262	7	90	90	NUM
iajs-2271	262	8	,	,	PUNCT
iajs-2271	262	9	doi	doi	NOUN
iajs-2271	262	10	:	:	PUNCT
iajs-2271	262	11	10.1093	10.1093	NUM
iajs-2271	262	12	/	/	SYM
iajs-2271	262	13	bib	bib	ADJ
iajs-2271	262	14	/	/	SYM
iajs-2271	262	15	bbv079	bbv079	NOUN
iajs-2271	262	16	.	.	PUNCT
iajs-2271	263	1	11	11	NUM
iajs-2271	263	2	.	.	PUNCT
iajs-2271	264	1	karp	karp	PROPN
iajs-2271	264	2	,	,	PUNCT
iajs-2271	264	3	p.d	p.d	PROPN
iajs-2271	264	4	.	.	PROPN
iajs-2271	264	5	;	;	PUNCT
iajs-2271	264	6	paley	paley	PROPN
iajs-2271	264	7	,	,	PUNCT
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iajs-2271	264	9	;	;	PUNCT
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iajs-2271	264	11	,	,	PUNCT
iajs-2271	264	12	p.	p.	NOUN
iajs-2271	264	13	the	the	DET
iajs-2271	264	14	pathway	pathway	NOUN
iajs-2271	264	15	tools	tool	NOUN
iajs-2271	264	16	software.bioinformatics.2002	software.bioinformatics.2002	PROPN
iajs-2271	264	17	,	,	PUNCT
iajs-2271	264	18	18	18	NUM
iajs-2271	264	19	,	,	PUNCT
iajs-2271	264	20	225	225	NUM
iajs-2271	264	21	-	-	SYM
iajs-2271	264	22	32	32	NUM
iajs-2271	264	23	,	,	PUNCT
iajs-2271	264	24	url	url	NOUN
iajs-2271	264	25	:	:	PUNCT
iajs-2271	264	26	http://www.ncbi.nlm.nih.gov/pubmed/12169551	http://www.ncbi.nlm.nih.gov/pubmed/12169551	X
iajs-2271	264	27	.	.	PROPN
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iajs-2271	265	2	.	.	PUNCT
iajs-2271	266	1	karp	karp	PROPN
iajs-2271	266	2	,	,	PUNCT
iajs-2271	266	3	p.d	p.d	PROPN
iajs-2271	266	4	.	.	PROPN
iajs-2271	266	5	;	;	PUNCT
iajs-2271	266	6	billington	billington	PROPN
iajs-2271	266	7	,	,	PUNCT
iajs-2271	266	8	r.	r.	PROPN
iajs-2271	266	9	;	;	PUNCT
iajs-2271	266	10	caspi	caspi	PROPN
iajs-2271	266	11	,	,	PUNCT
iajs-2271	266	12	r.	r.	PROPN
iajs-2271	266	13	;	;	PUNCT
iajs-2271	266	14	fulcher	fulcher	PROPN
iajs-2271	266	15	,	,	PUNCT
iajs-2271	266	16	c.a	c.a	PROPN
iajs-2271	266	17	.	.	PROPN
iajs-2271	266	18	;	;	PUNCT
iajs-2271	266	19	latendresse	latendresse	PROPN
iajs-2271	266	20	,	,	PUNCT
iajs-2271	266	21	m.	m.	NOUN
iajs-2271	266	22	;	;	PUNCT
iajs-2271	266	23	et	et	PROPN
iajs-2271	266	24	al	al	PROPN
iajs-2271	266	25	.	.	PUNCT
iajs-2271	267	1	the	the	DET
iajs-2271	267	2	biocyc	biocyc	NOUN
iajs-2271	267	3	collection	collection	NOUN
iajs-2271	267	4	of	of	ADP
iajs-2271	267	5	microbial	microbial	ADJ
iajs-2271	267	6	genomes	genome	NOUN
iajs-2271	267	7	and	and	CCONJ
iajs-2271	267	8	metabolic	metabolic	NOUN
iajs-2271	267	9	pathways	pathway	NOUN
iajs-2271	267	10	.	.	PUNCT
iajs-2271	268	1	brief	brief	ADJ
iajs-2271	268	2	bioinform.2017	bioinform.2017	PROPN
iajs-2271	268	3	,	,	PUNCT
iajs-2271	268	4	bbx085	bbx085	NOUN
iajs-2271	268	5	,	,	PUNCT
iajs-2271	268	6	doi:10.1093	doi:10.1093	NOUN
iajs-2271	268	7	/	/	SYM
iajs-2271	268	8	bib	bib	NOUN
iajs-2271	268	9	/	/	SYM
iajs-2271	268	10	bbx085	bbx085	NOUN
iajs-2271	268	11	.	.	PUNCT
iajs-2271	269	1	13	13	NUM
iajs-2271	269	2	.	.	X
iajs-2271	270	1	green	green	PROPN
iajs-2271	270	2	,	,	PUNCT
iajs-2271	270	3	m.l	m.l	PROPN
iajs-2271	270	4	.	.	PROPN
iajs-2271	270	5	;	;	PUNCT
iajs-2271	270	6	karp	karp	PROPN
iajs-2271	270	7	,	,	PUNCT
iajs-2271	270	8	p.d	p.d	PROPN
iajs-2271	270	9	.	.	PROPN
iajs-2271	270	10	a	a	DET
iajs-2271	270	11	bayesian	bayesian	NOUN
iajs-2271	270	12	method	method	NOUN
iajs-2271	270	13	for	for	ADP
iajs-2271	270	14	identifying	identify	VERB
iajs-2271	270	15	missing	miss	VERB
iajs-2271	270	16	enzymes	enzyme	NOUN
iajs-2271	270	17	in	in	ADP
iajs-2271	270	18	predicted	predict	VERB
iajs-2271	270	19	metabolic	metabolic	NOUN
iajs-2271	270	20	pathway	pathway	NOUN
iajs-2271	270	21	databases	database	NOUN
iajs-2271	270	22	.	.	PUNCT
iajs-2271	271	1	bmc	bmc	ADJ
iajs-2271	271	2	bioinformatics	bioinformatic	NOUN
iajs-2271	271	3	.	.	PUNCT
iajs-2271	272	1	2004	2004	NUM
iajs-2271	272	2	,	,	PUNCT
iajs-2271	272	3	5	5	NUM
iajs-2271	272	4	,	,	PUNCT
iajs-2271	272	5	76	76	NUM
iajs-2271	272	6	-	-	SYM
iajs-2271	272	7	91	91	NUM
iajs-2271	272	8	,	,	PUNCT
iajs-2271	272	9	doi	doi	NOUN
iajs-2271	272	10	:	:	PUNCT
iajs-2271	272	11	10.1186/1471	10.1186/1471	NUM
iajs-2271	272	12	-	-	PUNCT
iajs-2271	272	13	2105	2105	NUM
iajs-2271	272	14	-	-	PUNCT
iajs-2271	272	15	5	5	NUM
iajs-2271	272	16	-	-	NUM
iajs-2271	272	17	76	76	NUM
iajs-2271	272	18	.	.	PUNCT
iajs-2271	273	1	14	14	NUM
iajs-2271	273	2	.	.	PUNCT
iajs-2271	274	1	khayatt	khayatt	PROPN
iajs-2271	274	2	,	,	PUNCT
iajs-2271	274	3	b.i	b.i	PROPN
iajs-2271	274	4	.	.	PROPN
iajs-2271	274	5	bioinformatics	bioinformatic	NOUN
iajs-2271	274	6	curation	curation	NOUN
iajs-2271	274	7	of	of	ADP
iajs-2271	274	8	the	the	DET
iajs-2271	274	9	carbohydrate	carbohydrate	NOUN
iajs-2271	274	10	metabolism	metabolism	NOUN
iajs-2271	274	11	pathways	pathway	NOUN
iajs-2271	274	12	(	(	PUNCT
iajs-2271	274	13	entner	entner	NOUN
iajs-2271	274	14	-	-	PUNCT
iajs-2271	274	15	doudoroff	doudoroff	NOUN
iajs-2271	274	16	and	and	CCONJ
iajs-2271	274	17	tca	tca	PROPN
iajs-2271	274	18	cycle	cycle	NOUN
iajs-2271	274	19	)	)	PUNCT
iajs-2271	274	20	in	in	ADP
iajs-2271	274	21	sulfolobus	sulfolobus	ADJ
iajs-2271	274	22	solfataricus	solfataricus	ADJ
iajs-2271	274	23	p2	p2	NOUN
iajs-2271	274	24	.	.	PUNCT
iajs-2271	275	1	proceeding	proceeding	NOUN
iajs-2271	275	2	,	,	PUNCT
iajs-2271	275	3	world	world	NOUN
iajs-2271	275	4	agriculture	agriculture	PROPN
iajs-2271	275	5	congress(4th	congress(4th	PROPN
iajs-2271	275	6	world	world	PROPN
iajs-2271	275	7	research	research	NOUN
iajs-2271	275	8	journals	journal	NOUN
iajs-2271	275	9	congress	congress	PROPN
iajs-2271	275	10	)	)	PUNCT
iajs-2271	275	11	.	.	PUNCT
iajs-2271	276	1	2018	2018	NUM
iajs-2271	276	2	,	,	PUNCT
iajs-2271	276	3	timisoara	timisoara	PROPN
iajs-2271	276	4	;	;	PUNCT
iajs-2271	276	5	romania	romania	PROPN
iajs-2271	276	6	.	.	PUNCT
iajs-2271	277	1	15	15	NUM
iajs-2271	277	2	.	.	PUNCT
iajs-2271	278	1	ulas	ula	NOUN
iajs-2271	278	2	,	,	PUNCT
iajs-2271	278	3	t.	t.	PROPN
iajs-2271	278	4	;	;	PUNCT
iajs-2271	278	5	riemer	riemer	PROPN
iajs-2271	278	6	,	,	PUNCT
iajs-2271	278	7	s.a	s.a	PROPN
iajs-2271	278	8	.	.	PROPN
iajs-2271	278	9	;	;	PUNCT
iajs-2271	279	1	zaparty	zaparty	NOUN
iajs-2271	279	2	,	,	PUNCT
iajs-2271	279	3	m.	m.	NOUN
iajs-2271	279	4	;	;	PUNCT
iajs-2271	279	5	siebers	sieber	NOUN
iajs-2271	279	6	,	,	PUNCT
iajs-2271	279	7	b.	b.	PROPN
iajs-2271	279	8	;	;	PUNCT
iajs-2271	279	9	schomburg	schomburg	PROPN
iajs-2271	279	10	,	,	PUNCT
iajs-2271	279	11	d.	d.	NOUN
iajs-2271	279	12	genome	genome	NOUN
iajs-2271	279	13	-	-	PUNCT
iajs-2271	279	14	scale	scale	NOUN
iajs-2271	279	15	reconstruction	reconstruction	NOUN
iajs-2271	279	16	and	and	CCONJ
iajs-2271	279	17	analysis	analysis	NOUN
iajs-2271	279	18	of	of	ADP
iajs-2271	279	19	the	the	DET
iajs-2271	279	20	metabolic	metabolic	NOUN
iajs-2271	279	21	network	network	NOUN
iajs-2271	279	22	in	in	ADP
iajs-2271	279	23	the	the	DET
iajs-2271	279	24	hyperthermophilic	hyperthermophilic	ADJ
iajs-2271	279	25	archaeon	archaeon	NOUN
iajs-2271	279	26	sulfolobus	sulfolobus	NOUN
iajs-2271	279	27	solfataricus	solfataricus	NOUN
iajs-2271	279	28	.	.	PUNCT
iajs-2271	280	1	plos	plos	PROPN
iajs-2271	280	2	one.2012	one.2012	ADV
iajs-2271	280	3	,	,	PUNCT
iajs-2271	280	4	7	7	NUM
iajs-2271	280	5	,	,	PUNCT
iajs-2271	280	6	e43401	e43401	NUM
iajs-2271	280	7	,	,	PUNCT
iajs-2271	280	8	doi	doi	NOUN
iajs-2271	280	9	:	:	PUNCT
iajs-2271	280	10	10.1371	10.1371	NUM
iajs-2271	280	11	/	/	SYM
iajs-2271	280	12	journal.pone.0043401	journal.pone.0043401	PROPN
iajs-2271	280	13	.	.	PROPN
iajs-2271	280	14	16	16	NUM
iajs-2271	280	15	.	.	PUNCT
iajs-2271	281	1	wolf	wolf	PROPN
iajs-2271	281	2	,	,	PUNCT
iajs-2271	281	3	j.	j.	PROPN
iajs-2271	281	4	;	;	PUNCT
iajs-2271	281	5	stark	stark	PROPN
iajs-2271	281	6	,	,	PUNCT
iajs-2271	281	7	h.	h.	PROPN
iajs-2271	281	8	;	;	PUNCT
iajs-2271	281	9	fafenrot	fafenrot	PROPN
iajs-2271	281	10	,	,	PUNCT
iajs-2271	281	11	k.	k.	PROPN
iajs-2271	281	12	;	;	PUNCT
iajs-2271	281	13	albersmeier	albersmeier	NOUN
iajs-2271	281	14	,	,	PUNCT
iajs-2271	281	15	a.	a.	NOUN
iajs-2271	281	16	;	;	PUNCT
iajs-2271	281	17	pham	pham	PROPN
iajs-2271	281	18	,	,	PUNCT
iajs-2271	281	19	t.k	t.k	PROPN
iajs-2271	281	20	.	.	PROPN
iajs-2271	281	21	;	;	PUNCT
iajs-2271	281	22	et	et	PROPN
iajs-2271	281	23	al	al	PROPN
iajs-2271	281	24	.	.	PUNCT
iajs-2271	282	1	a	a	DET
iajs-2271	282	2	systems	system	NOUN
iajs-2271	282	3	biology	biology	NOUN
iajs-2271	282	4	approach	approach	NOUN
iajs-2271	282	5	reveals	reveal	VERB
iajs-2271	282	6	major	major	ADJ
iajs-2271	282	7	metabolic	metabolic	NOUN
iajs-2271	282	8	changes	change	NOUN
iajs-2271	282	9	in	in	ADP
iajs-2271	282	10	the	the	DET
iajs-2271	282	11	thermoacidophilic	thermoacidophilic	NOUN
iajs-2271	282	12	archaeon	archaeon	NOUN
iajs-2271	282	13	sulfolobus	sulfolobus	NOUN
iajs-2271	282	14	solfataricus	solfataricus	NOUN
iajs-2271	282	15	in	in	ADP
iajs-2271	282	16	response	response	NOUN
iajs-2271	282	17	to	to	ADP
iajs-2271	282	18	the	the	DET
iajs-2271	282	19	carbon	carbon	NOUN
iajs-2271	282	20	source	source	NOUN
iajs-2271	282	21	l	l	NOUN
iajs-2271	282	22	-	-	NOUN
iajs-2271	282	23	fucose	fucose	NOUN
iajs-2271	282	24	versus	versus	ADP
iajs-2271	282	25	d	d	NOUN
iajs-2271	282	26	-	-	PUNCT
iajs-2271	282	27	glucose	glucose	NOUN
iajs-2271	282	28	.	.	PUNCT
iajs-2271	283	1	mol	mol	ADP
iajs-2271	283	2	microbiol	microbiol	PROPN
iajs-2271	283	3	.	.	PUNCT
iajs-2271	284	1	2016	2016	NUM
iajs-2271	284	2	,	,	PUNCT
iajs-2271	284	3	102	102	NUM
iajs-2271	284	4	,	,	PUNCT
iajs-2271	284	5	882	882	NUM
iajs-2271	284	6	-	-	SYM
iajs-2271	284	7	908	908	NUM
iajs-2271	284	8	,	,	PUNCT
iajs-2271	284	9	doi	doi	NOUN
iajs-2271	284	10	:	:	PUNCT
iajs-2271	284	11	10.1111	10.1111	NUM
iajs-2271	284	12	/	/	SYM
iajs-2271	284	13	mmi.13498	mmi.13498	NUM
iajs-2271	284	14	.	.	PROPN
iajs-2271	284	15	17	17	NUM
iajs-2271	285	1	ibn	ibn	PROPN
iajs-2271	285	2	al	al	PROPN
iajs-2271	285	3	-	-	PUNCT
iajs-2271	285	4	haitham	haitham	PROPN
iajs-2271	285	5	jour	jour	X
iajs-2271	285	6	.	.	PROPN
iajs-2271	285	7	for	for	ADP
iajs-2271	285	8	pure	pure	ADJ
iajs-2271	285	9	&	&	CCONJ
iajs-2271	285	10	appl	appl	PROPN
iajs-2271	285	11	.	.	PUNCT
iajs-2271	286	1	sci	sci	PROPN
iajs-2271	286	2	.	.	PROPN
iajs-2271	286	3	32	32	NUM
iajs-2271	286	4	(	(	PUNCT
iajs-2271	286	5	3	3	NUM
iajs-2271	286	6	)	)	PUNCT
iajs-2271	286	7	2019	2019	NUM
iajs-2271	286	8	17	17	NUM
iajs-2271	286	9	.	.	PUNCT
iajs-2271	287	1	grogan	grogan	PROPN
iajs-2271	287	2	,	,	PUNCT
iajs-2271	287	3	d.w	d.w	PROPN
iajs-2271	287	4	.	.	PROPN
iajs-2271	287	5	phenotypic	phenotypic	ADJ
iajs-2271	287	6	characterization	characterization	NOUN
iajs-2271	287	7	of	of	ADP
iajs-2271	287	8	the	the	DET
iajs-2271	287	9	archaebacterial	archaebacterial	ADJ
iajs-2271	287	10	genus	genus	NOUN
iajs-2271	287	11	sulfolobus	sulfolobus	NOUN
iajs-2271	287	12	:	:	PUNCT
iajs-2271	287	13	comparison	comparison	NOUN
iajs-2271	287	14	of	of	ADP
iajs-2271	287	15	five	five	NUM
iajs-2271	287	16	wild	wild	ADJ
iajs-2271	287	17	-	-	PUNCT
iajs-2271	287	18	type	type	NOUN
iajs-2271	287	19	strains	strain	NOUN
iajs-2271	287	20	.	.	PUNCT
iajs-2271	288	1	j.	j.	PROPN
iajs-2271	288	2	bacteriol	bacteriol	PROPN
iajs-2271	288	3	.	.	PUNCT
iajs-2271	289	1	1989	1989	NUM
iajs-2271	289	2	,	,	PUNCT
iajs-2271	289	3	171	171	NUM
iajs-2271	289	4	,	,	PUNCT
iajs-2271	289	5	6710	6710	NUM
iajs-2271	289	6	-	-	SYM
iajs-2271	289	7	9	9	NUM
iajs-2271	289	8	,	,	PUNCT
iajs-2271	289	9	url	url	NOUN
iajs-2271	289	10	:	:	PUNCT
iajs-2271	289	11	http://www.ncbi.nlm.nih.gov/pubmed/2512283	http://www.ncbi.nlm.nih.gov/pubmed/2512283	NUM
iajs-2271	289	12	.	.	PROPN
iajs-2271	290	1	18	18	NUM
iajs-2271	290	2	.	.	X
iajs-2271	290	3	kitabatake	kitabatake	NOUN
iajs-2271	290	4	,	,	PUNCT
iajs-2271	290	5	m.	m.	NOUN
iajs-2271	290	6	;	;	PUNCT
iajs-2271	290	7	so	so	CCONJ
iajs-2271	290	8	,	,	PUNCT
iajs-2271	290	9	m.w	m.w	PROPN
iajs-2271	290	10	.	.	PROPN
iajs-2271	290	11	;	;	PUNCT
iajs-2271	290	12	tumbula	tumbula	PROPN
iajs-2271	290	13	,	,	PUNCT
iajs-2271	290	14	d.l	d.l	PROPN
iajs-2271	290	15	.	.	PROPN
iajs-2271	290	16	;	;	PUNCT
iajs-2271	290	17	soll	soll	PROPN
iajs-2271	290	18	,	,	PUNCT
iajs-2271	290	19	d.	d.	PROPN
iajs-2271	290	20	cysteine	cysteine	PROPN
iajs-2271	290	21	biosynthesis	biosynthesis	NOUN
iajs-2271	290	22	pathway	pathway	NOUN
iajs-2271	290	23	in	in	ADP
iajs-2271	290	24	the	the	DET
iajs-2271	290	25	archaeon	archaeon	NOUN
iajs-2271	290	26	methanosarcina	methanosarcina	NOUN
iajs-2271	290	27	barkeri	barkeri	PROPN
iajs-2271	290	28	encoded	encode	VERB
iajs-2271	290	29	by	by	ADP
iajs-2271	290	30	acquired	acquire	VERB
iajs-2271	290	31	bacterial	bacterial	ADJ
iajs-2271	290	32	genes	gene	NOUN
iajs-2271	290	33	.	.	PUNCT
iajs-2271	291	1	j	j	PROPN
iajs-2271	291	2	bacteriol.2000	bacteriol.2000	PROPN
iajs-2271	291	3	,	,	PUNCT
iajs-2271	291	4	182	182	NUM
iajs-2271	291	5	,	,	PUNCT
iajs-2271	291	6	143	143	NUM
iajs-2271	291	7	-	-	SYM
iajs-2271	291	8	5	5	NUM
iajs-2271	291	9	,	,	PUNCT
iajs-2271	291	10	url	url	NOUN
iajs-2271	291	11	:	:	PUNCT
iajs-2271	291	12	http://www.ncbi.nlm.nih.gov/pubmed/10613873	http://www.ncbi.nlm.nih.gov/pubmed/10613873	NUM
iajs-2271	291	13	.	.	NOUN
iajs-2271	292	1	19	19	NUM
iajs-2271	292	2	.	.	PUNCT
iajs-2271	292	3	brilli	brilli	PROPN
iajs-2271	292	4	,	,	PUNCT
iajs-2271	292	5	m.	m.	NOUN
iajs-2271	292	6	;	;	PUNCT
iajs-2271	292	7	fani	fani	PROPN
iajs-2271	292	8	,	,	PUNCT
iajs-2271	292	9	r.	r.	X
iajs-2271	292	10	molecular	molecular	ADJ
iajs-2271	292	11	evolution	evolution	NOUN
iajs-2271	292	12	of	of	ADP
iajs-2271	292	13	hisb	hisb	ADJ
iajs-2271	292	14	genes	gene	NOUN
iajs-2271	292	15	.	.	PUNCT
iajs-2271	293	1	j	j	PROPN
iajs-2271	293	2	mol	mol	ADP
iajs-2271	293	3	evol	evol	NOUN
iajs-2271	293	4	.	.	PUNCT
iajs-2271	294	1	2004	2004	NUM
iajs-2271	294	2	,	,	PUNCT
iajs-2271	294	3	58	58	NUM
iajs-2271	294	4	,	,	PUNCT
iajs-2271	294	5	225	225	NUM
iajs-2271	294	6	-	-	SYM
iajs-2271	294	7	37	37	NUM
iajs-2271	294	8	,	,	PUNCT
iajs-2271	294	9	doi	doi	NOUN
iajs-2271	294	10	:	:	PUNCT
iajs-2271	294	11	10.1007	10.1007	NUM
iajs-2271	294	12	/	/	SYM
iajs-2271	294	13	s00239	s00239	NOUN
iajs-2271	294	14	-	-	PUNCT
iajs-2271	294	15	003	003	NUM
iajs-2271	294	16	-	-	PUNCT
iajs-2271	294	17	2547	2547	NUM
iajs-2271	294	18	-	-	PUNCT
iajs-2271	294	19	x.	x.	NOUN
iajs-2271	294	20	20	20	NUM
iajs-2271	294	21	.	.	PUNCT
iajs-2271	295	1	kanehisa	kanehisa	NOUN
iajs-2271	295	2	,	,	PUNCT
iajs-2271	295	3	m.	m.	NOUN
iajs-2271	295	4	;	;	PUNCT
iajs-2271	295	5	goto	goto	NOUN
iajs-2271	295	6	,	,	PUNCT
iajs-2271	295	7	s.	s.	PROPN
iajs-2271	295	8	;	;	PUNCT
iajs-2271	295	9	kawashima	kawashima	PROPN
iajs-2271	295	10	,	,	PUNCT
iajs-2271	295	11	s.	s.	PROPN
iajs-2271	295	12	;	;	PUNCT
iajs-2271	295	13	nakaya	nakaya	PROPN
iajs-2271	295	14	,	,	PUNCT
iajs-2271	295	15	a.	a.	NOUN
iajs-2271	295	16	the	the	DET
iajs-2271	295	17	kegg	kegg	NOUN
iajs-2271	295	18	databases	database	NOUN
iajs-2271	295	19	at	at	ADP
iajs-2271	295	20	genomenet	genomenet	NOUN
iajs-2271	295	21	.	.	PUNCT
iajs-2271	296	1	nucleic	nucleic	ADJ
iajs-2271	296	2	acids	acid	NOUN
iajs-2271	296	3	res	re	NOUN
iajs-2271	296	4	.	.	PUNCT
iajs-2271	296	5	2002	2002	NUM
iajs-2271	296	6	,	,	PUNCT
iajs-2271	296	7	30	30	NUM
iajs-2271	296	8	,	,	PUNCT
iajs-2271	296	9	42	42	NUM
iajs-2271	296	10	-	-	SYM
iajs-2271	296	11	6	6	NUM
iajs-2271	296	12	,	,	PUNCT
iajs-2271	296	13	url	url	NOUN
iajs-2271	296	14	:	:	PUNCT
iajs-2271	296	15	http://www.ncbi.nlm.nih.gov/pubmed/11752249	http://www.ncbi.nlm.nih.gov/pubmed/11752249	X
iajs-2271	296	16	.	.	PROPN
iajs-2271	296	17	21	21	NUM
iajs-2271	296	18	.	.	PUNCT
iajs-2271	297	1	kanehisa	kanehisa	NOUN
iajs-2271	297	2	,	,	PUNCT
iajs-2271	297	3	m.	m.	NOUN
iajs-2271	297	4	;	;	PUNCT
iajs-2271	297	5	sato	sato	PROPN
iajs-2271	297	6	,	,	PUNCT
iajs-2271	297	7	y.	y.	PROPN
iajs-2271	297	8	;	;	PUNCT
iajs-2271	297	9	furumichi	furumichi	PROPN
iajs-2271	297	10	,	,	PUNCT
iajs-2271	297	11	m.	m.	NOUN
iajs-2271	297	12	;	;	PUNCT
iajs-2271	297	13	morishima	morishima	PROPN
iajs-2271	297	14	,	,	PUNCT
iajs-2271	297	15	k.	k.	PROPN
iajs-2271	297	16	;	;	PUNCT
iajs-2271	297	17	tanabe	tanabe	PROPN
iajs-2271	297	18	,	,	PUNCT
iajs-2271	297	19	m.	m.	NOUN
iajs-2271	297	20	new	new	ADJ
iajs-2271	297	21	approach	approach	NOUN
iajs-2271	297	22	for	for	ADP
iajs-2271	297	23	understanding	understand	VERB
iajs-2271	297	24	genome	genome	NOUN
iajs-2271	297	25	variations	variation	NOUN
iajs-2271	297	26	in	in	ADP
iajs-2271	297	27	kegg	kegg	NOUN
iajs-2271	297	28	.	.	PUNCT
iajs-2271	298	1	nucleic	nucleic	ADJ
iajs-2271	298	2	acids	acid	NOUN
iajs-2271	298	3	res.2018	res.2018	NOUN
iajs-2271	298	4	,	,	PUNCT
iajs-2271	298	5	47	47	NUM
iajs-2271	298	6	,	,	PUNCT
iajs-2271	298	7	d590	d590	PROPN
iajs-2271	298	8	–	–	PUNCT
iajs-2271	298	9	d595	d595	PROPN
iajs-2271	298	10	,	,	PUNCT
iajs-2271	298	11	doi	doi	NOUN
iajs-2271	298	12	:	:	PUNCT
iajs-2271	298	13	10.1093	10.1093	NUM
iajs-2271	298	14	/	/	SYM
iajs-2271	298	15	nar	nar	NOUN
iajs-2271	298	16	/	/	SYM
iajs-2271	298	17	gky962	gky962	PROPN
iajs-2271	298	18	.	.	PUNCT
iajs-2271	299	1	22	22	NUM
iajs-2271	299	2	.	.	PUNCT
iajs-2271	300	1	johnson	johnson	PROPN
iajs-2271	300	2	,	,	PUNCT
iajs-2271	300	3	m.	m.	NOUN
iajs-2271	300	4	;	;	PUNCT
iajs-2271	300	5	zaretskaya	zaretskaya	PROPN
iajs-2271	300	6	,	,	PUNCT
iajs-2271	300	7	i.	i.	PROPN
iajs-2271	300	8	;	;	PUNCT
iajs-2271	300	9	raytselis	raytselis	PROPN
iajs-2271	300	10	,	,	PUNCT
iajs-2271	300	11	y.	y.	PROPN
iajs-2271	300	12	;	;	PUNCT
iajs-2271	300	13	merezhuk	merezhuk	PROPN
iajs-2271	300	14	,	,	PUNCT
iajs-2271	300	15	y.	y.	PROPN
iajs-2271	300	16	;	;	PUNCT
iajs-2271	300	17	mcginnis	mcginnis	PROPN
iajs-2271	300	18	,	,	PUNCT
iajs-2271	300	19	s.	s.	PROPN
iajs-2271	300	20	;	;	PUNCT
iajs-2271	300	21	madden	madden	PROPN
iajs-2271	300	22	,	,	PUNCT
iajs-2271	300	23	t.l	t.l	PROPN
iajs-2271	300	24	.	.	PUNCT
iajs-2271	300	25	ncbi	ncbi	PROPN
iajs-2271	300	26	blast	blast	PROPN
iajs-2271	300	27	:	:	PUNCT
iajs-2271	300	28	a	a	DET
iajs-2271	300	29	better	well	ADJ
iajs-2271	300	30	web	web	NOUN
iajs-2271	300	31	interface	interface	NOUN
iajs-2271	300	32	.	.	PUNCT
iajs-2271	301	1	nucleic	nucleic	ADJ
iajs-2271	301	2	acids	acid	NOUN
iajs-2271	301	3	res	re	NOUN
iajs-2271	301	4	.	.	PUNCT
iajs-2271	301	5	2008	2008	NUM
iajs-2271	301	6	,	,	PUNCT
iajs-2271	301	7	36	36	NUM
iajs-2271	301	8	,	,	PUNCT
iajs-2271	301	9	5	5	NUM
iajs-2271	301	10	-	-	SYM
iajs-2271	301	11	9	9	NUM
iajs-2271	301	12	,	,	PUNCT
iajs-2271	301	13	doi	doi	NOUN
iajs-2271	301	14	:	:	PUNCT
iajs-2271	301	15	10.1093	10.1093	NUM
iajs-2271	301	16	/	/	SYM
iajs-2271	301	17	nar	nar	NOUN
iajs-2271	301	18	/	/	SYM
iajs-2271	301	19	gkn201	gkn201	NOUN
iajs-2271	301	20	.	.	PUNCT
iajs-2271	302	1	23	23	NUM
iajs-2271	302	2	.	.	X
iajs-2271	303	1	makarova	makarova	PROPN
iajs-2271	303	2	,	,	PUNCT
iajs-2271	303	3	k.s	k.s	PROPN
iajs-2271	303	4	.	.	PROPN
iajs-2271	303	5	;	;	PUNCT
iajs-2271	303	6	wolf	wolf	PROPN
iajs-2271	303	7	,	,	PUNCT
iajs-2271	303	8	y.i	y.i	PROPN
iajs-2271	303	9	.	.	PROPN
iajs-2271	303	10	;	;	PUNCT
iajs-2271	303	11	koonin	koonin	X
iajs-2271	303	12	,	,	PUNCT
iajs-2271	303	13	e.v	e.v	PROPN
iajs-2271	303	14	.	.	PROPN
iajs-2271	303	15	archaeal	archaeal	ADJ
iajs-2271	303	16	clusters	cluster	NOUN
iajs-2271	303	17	of	of	ADP
iajs-2271	303	18	orthologous	orthologous	ADJ
iajs-2271	303	19	genes	gene	NOUN
iajs-2271	303	20	(	(	PUNCT
iajs-2271	303	21	arcogs	arcog	NOUN
iajs-2271	303	22	):	):	PUNCT
iajs-2271	303	23	an	an	DET
iajs-2271	303	24	update	update	NOUN
iajs-2271	303	25	and	and	CCONJ
iajs-2271	303	26	application	application	NOUN
iajs-2271	303	27	for	for	ADP
iajs-2271	303	28	analysis	analysis	NOUN
iajs-2271	303	29	of	of	ADP
iajs-2271	303	30	shared	share	VERB
iajs-2271	303	31	features	feature	NOUN
iajs-2271	303	32	between	between	ADP
iajs-2271	303	33	thermococcales	thermococcale	NOUN
iajs-2271	303	34	,	,	PUNCT
iajs-2271	303	35	methanococcales	methanococcale	NOUN
iajs-2271	303	36	,	,	PUNCT
iajs-2271	303	37	and	and	CCONJ
iajs-2271	303	38	methanobacteriales	methanobacteriale	NOUN
iajs-2271	303	39	.	.	PUNCT
iajs-2271	304	1	life	life	NOUN
iajs-2271	304	2	(	(	PUNCT
iajs-2271	304	3	basel).2015	basel).2015	PROPN
iajs-2271	304	4	,	,	PUNCT
iajs-2271	304	5	5	5	NUM
iajs-2271	304	6	,	,	PUNCT
iajs-2271	304	7	81840	81840	NUM
iajs-2271	304	8	,	,	PUNCT
iajs-2271	304	9	doi	doi	NOUN
iajs-2271	304	10	:	:	PUNCT
iajs-2271	304	11	10.3390	10.3390	NUM
iajs-2271	304	12	/	/	SYM
iajs-2271	304	13	life5010818	life5010818	PROPN
iajs-2271	304	14	.	.	PUNCT
iajs-2271	305	1	24	24	NUM
iajs-2271	305	2	.	.	X
iajs-2271	305	3	gabaldon	gabaldon	PROPN
iajs-2271	305	4	,	,	PUNCT
iajs-2271	305	5	t.	t.	PROPN
iajs-2271	305	6	;	;	PUNCT
iajs-2271	305	7	huynen	huynen	PROPN
iajs-2271	305	8	,	,	PUNCT
iajs-2271	305	9	m.a	m.a	PROPN
iajs-2271	305	10	.	.	PROPN
iajs-2271	305	11	prediction	prediction	NOUN
iajs-2271	305	12	of	of	ADP
iajs-2271	305	13	protein	protein	NOUN
iajs-2271	305	14	function	function	NOUN
iajs-2271	305	15	and	and	CCONJ
iajs-2271	305	16	pathways	pathway	NOUN
iajs-2271	305	17	in	in	ADP
iajs-2271	305	18	the	the	DET
iajs-2271	305	19	genome	genome	NOUN
iajs-2271	305	20	era	era	NOUN
iajs-2271	305	21	.	.	PUNCT
iajs-2271	306	1	cell	cell	NOUN
iajs-2271	306	2	mol	mol	ADP
iajs-2271	306	3	life	life	NOUN
iajs-2271	306	4	sci	sci	PROPN
iajs-2271	306	5	2004	2004	NUM
iajs-2271	306	6	,	,	PUNCT
iajs-2271	306	7	61	61	NUM
iajs-2271	306	8	,	,	PUNCT
iajs-2271	306	9	930	930	NUM
iajs-2271	306	10	-	-	SYM
iajs-2271	306	11	44	44	NUM
iajs-2271	306	12	,	,	PUNCT
iajs-2271	306	13	doi	doi	NOUN
iajs-2271	306	14	:	:	PUNCT
iajs-2271	306	15	10.1007	10.1007	NUM
iajs-2271	306	16	/	/	SYM
iajs-2271	306	17	s00018	s00018	NOUN
iajs-2271	306	18	-	-	PUNCT
iajs-2271	306	19	003	003	NUM
iajs-2271	306	20	-	-	PUNCT
iajs-2271	306	21	3387	3387	NUM
iajs-2271	306	22	-	-	PUNCT
iajs-2271	306	23	y.	y.	NOUN
iajs-2271	306	24	25	25	NUM
iajs-2271	306	25	.	.	PUNCT
iajs-2271	307	1	tsoka	tsoka	PROPN
iajs-2271	307	2	,	,	PUNCT
iajs-2271	307	3	s.	s.	PROPN
iajs-2271	307	4	;	;	PUNCT
iajs-2271	307	5	simon	simon	PROPN
iajs-2271	307	6	,	,	PUNCT
iajs-2271	307	7	d.	d.	PROPN
iajs-2271	307	8	;	;	PUNCT
iajs-2271	307	9	ouzounis	ouzounis	PROPN
iajs-2271	307	10	,	,	PUNCT
iajs-2271	307	11	c.a	c.a	PROPN
iajs-2271	307	12	.	.	PROPN
iajs-2271	307	13	automated	automate	VERB
iajs-2271	307	14	metabolic	metabolic	NOUN
iajs-2271	307	15	reconstruction	reconstruction	NOUN
iajs-2271	307	16	for	for	ADP
iajs-2271	307	17	methanococcus	methanococcus	NOUN
iajs-2271	307	18	jannaschii	jannaschii	NOUN
iajs-2271	307	19	.	.	PUNCT
iajs-2271	308	1	archaea	archaea	PROPN
iajs-2271	308	2	.	.	PUNCT
iajs-2271	309	1	2004	2004	NUM
iajs-2271	309	2	,	,	PUNCT
iajs-2271	309	3	1	1	NUM
iajs-2271	309	4	,	,	PUNCT
iajs-2271	309	5	223	223	NUM
iajs-2271	309	6	-	-	SYM
iajs-2271	309	7	9	9	NUM
iajs-2271	309	8	,	,	PUNCT
iajs-2271	309	9	url	url	NOUN
iajs-2271	309	10	:	:	PUNCT
iajs-2271	309	11	http://www.ncbi.nlm.nih.gov/pubmed/15810431	http://www.ncbi.nlm.nih.gov/pubmed/15810431	NUM
iajs-2271	309	12	.	.	PUNCT
iajs-2271	310	1	26	26	NUM
iajs-2271	310	2	.	.	X
iajs-2271	311	1	daugherty	daugherty	PROPN
iajs-2271	311	2	,	,	PUNCT
iajs-2271	311	3	m.	m.	NOUN
iajs-2271	311	4	;	;	PUNCT
iajs-2271	311	5	vonstein	vonstein	ADJ
iajs-2271	311	6	,	,	PUNCT
iajs-2271	311	7	v.	v.	PROPN
iajs-2271	311	8	;	;	PUNCT
iajs-2271	311	9	overbeek	overbeek	PROPN
iajs-2271	311	10	,	,	PUNCT
iajs-2271	311	11	r.	r.	PROPN
iajs-2271	311	12	;	;	PUNCT
iajs-2271	311	13	osterman	osterman	PROPN
iajs-2271	311	14	,	,	PUNCT
iajs-2271	311	15	a.	a.	NOUN
iajs-2271	311	16	archaeal	archaeal	PROPN
iajs-2271	311	17	shikimate	shikimate	NOUN
iajs-2271	311	18	kinase	kinase	PROPN
iajs-2271	311	19	,	,	PUNCT
iajs-2271	311	20	a	a	DET
iajs-2271	311	21	new	new	ADJ
iajs-2271	311	22	member	member	NOUN
iajs-2271	311	23	of	of	ADP
iajs-2271	311	24	the	the	DET
iajs-2271	311	25	ghmp	ghmp	PROPN
iajs-2271	311	26	-	-	PUNCT
iajs-2271	311	27	kinase	kinase	PROPN
iajs-2271	311	28	family	family	NOUN
iajs-2271	311	29	.	.	PUNCT
iajs-2271	312	1	j	j	PROPN
iajs-2271	312	2	bacteriol	bacteriol	NOUN
iajs-2271	312	3	.	.	PUNCT
iajs-2271	313	1	2001	2001	NUM
iajs-2271	313	2	,	,	PUNCT
iajs-2271	313	3	183	183	NUM
iajs-2271	313	4	,	,	PUNCT
iajs-2271	313	5	292	292	NUM
iajs-2271	313	6	-	-	SYM
iajs-2271	313	7	300	300	NUM
iajs-2271	313	8	,	,	PUNCT
iajs-2271	313	9	doi	doi	NOUN
iajs-2271	313	10	:	:	PUNCT
iajs-2271	313	11	10.1128	10.1128	NUM
iajs-2271	313	12	/	/	SYM
iajs-2271	313	13	jb.183.1.292300.2001	jb.183.1.292300.2001	NOUN
iajs-2271	313	14	.	.	PUNCT
iajs-2271	314	1	27	27	NUM
iajs-2271	314	2	.	.	PUNCT
iajs-2271	315	1	ward	ward	NOUN
iajs-2271	315	2	,	,	PUNCT
iajs-2271	315	3	d.e	d.e	PROPN
iajs-2271	315	4	.	.	PROPN
iajs-2271	315	5	;	;	PUNCT
iajs-2271	315	6	de	de	X
iajs-2271	315	7	vos	vos	PROPN
iajs-2271	315	8	,	,	PUNCT
iajs-2271	315	9	w.m	w.m	PROPN
iajs-2271	315	10	.	.	PROPN
iajs-2271	315	11	;	;	PUNCT
iajs-2271	315	12	van	van	PROPN
iajs-2271	315	13	der	der	PROPN
iajs-2271	315	14	oost	oost	PROPN
iajs-2271	315	15	,	,	PUNCT
iajs-2271	315	16	j.	j.	PROPN
iajs-2271	315	17	molecular	molecular	ADJ
iajs-2271	315	18	analysis	analysis	NOUN
iajs-2271	315	19	of	of	ADP
iajs-2271	315	20	the	the	DET
iajs-2271	315	21	role	role	NOUN
iajs-2271	315	22	of	of	ADP
iajs-2271	315	23	two	two	NUM
iajs-2271	315	24	aromatic	aromatic	ADJ
iajs-2271	315	25	aminotransferases	aminotransferase	NOUN
iajs-2271	315	26	and	and	CCONJ
iajs-2271	315	27	a	a	DET
iajs-2271	315	28	broad	broad	ADJ
iajs-2271	315	29	-	-	PUNCT
iajs-2271	315	30	specificity	specificity	NOUN
iajs-2271	315	31	aspartate	aspartate	NOUN
iajs-2271	315	32	aminotransferase	aminotransferase	NOUN
iajs-2271	315	33	in	in	ADP
iajs-2271	315	34	the	the	DET
iajs-2271	315	35	aromatic	aromatic	ADJ
iajs-2271	315	36	amino	amino	NOUN
iajs-2271	315	37	acid	acid	NOUN
iajs-2271	315	38	metabolism	metabolism	NOUN
iajs-2271	315	39	of	of	ADP
iajs-2271	315	40	pyrococcus	pyrococcus	ADJ
iajs-2271	315	41	furiosus	furiosus	PROPN
iajs-2271	315	42	.	.	PUNCT
iajs-2271	316	1	archaea.2002	archaea.2002	PROPN
iajs-2271	316	2	,	,	PUNCT
iajs-2271	316	3	1	1	NUM
iajs-2271	316	4	,	,	PUNCT
iajs-2271	316	5	133	133	NUM
iajs-2271	316	6	-	-	SYM
iajs-2271	316	7	41	41	NUM
iajs-2271	316	8	,	,	PUNCT
iajs-2271	316	9	url	url	NOUN
iajs-2271	316	10	:	:	PUNCT
iajs-2271	316	11	http://www.ncbi.nlm.nih.gov/pubmed/15803651	http://www.ncbi.nlm.nih.gov/pubmed/15803651	NUM
iajs-2271	316	12	.	.	NOUN
iajs-2271	316	13	28	28	NUM
iajs-2271	316	14	.	.	PUNCT
iajs-2271	316	15	cubellis	cubellis	PROPN
iajs-2271	316	16	,	,	PUNCT
iajs-2271	316	17	m.v	m.v	PROPN
iajs-2271	316	18	.	.	PROPN
iajs-2271	316	19	;	;	PUNCT
iajs-2271	316	20	rozzo	rozzo	PROPN
iajs-2271	316	21	,	,	PUNCT
iajs-2271	316	22	c.	c.	PROPN
iajs-2271	316	23	;	;	PUNCT
iajs-2271	316	24	nitti	nitti	PROPN
iajs-2271	316	25	,	,	PUNCT
iajs-2271	316	26	g.	g.	PROPN
iajs-2271	316	27	;	;	PUNCT
iajs-2271	316	28	arnone	arnone	NOUN
iajs-2271	316	29	,	,	PUNCT
iajs-2271	316	30	m.i	m.i	PROPN
iajs-2271	316	31	.	.	PROPN
iajs-2271	316	32	;	;	PUNCT
iajs-2271	316	33	marino	marino	PROPN
iajs-2271	316	34	,	,	PUNCT
iajs-2271	316	35	g.	g.	PROPN
iajs-2271	316	36	;	;	PUNCT
iajs-2271	316	37	sannia	sannia	PROPN
iajs-2271	316	38	,	,	PUNCT
iajs-2271	316	39	g.	g.	PROPN
iajs-2271	316	40	cloning	cloning	NOUN
iajs-2271	316	41	and	and	CCONJ
iajs-2271	316	42	sequencing	sequencing	NOUN
iajs-2271	316	43	of	of	ADP
iajs-2271	316	44	the	the	DET
iajs-2271	316	45	gene	gene	NOUN
iajs-2271	316	46	coding	code	VERB
iajs-2271	316	47	for	for	ADP
iajs-2271	316	48	aspartate	aspartate	NOUN
iajs-2271	316	49	aminotransferase	aminotransferase	NOUN
iajs-2271	316	50	from	from	ADP
iajs-2271	316	51	the	the	DET
iajs-2271	316	52	thermoacidophilic	thermoacidophilic	NOUN
iajs-2271	316	53	archaebacterium	archaebacterium	NOUN
iajs-2271	316	54	sulfolobus	sulfolobus	NOUN
iajs-2271	316	55	solfataricus	solfataricus	NOUN
iajs-2271	316	56	.	.	PUNCT
iajs-2271	317	1	eur	eur	PROPN
iajs-2271	317	2	j	j	PROPN
iajs-2271	317	3	biochem.1989	biochem.1989	PROPN
iajs-2271	317	4	,	,	PUNCT
iajs-2271	317	5	186	186	NUM
iajs-2271	317	6	,	,	PUNCT
iajs-2271	317	7	375	375	NUM
iajs-2271	317	8	-	-	SYM
iajs-2271	317	9	81	81	NUM
iajs-2271	317	10	,	,	PUNCT
iajs-2271	317	11	url	url	NOUN
iajs-2271	317	12	:	:	PUNCT
iajs-2271	317	13	http://www.ncbi.nlm.nih.gov/pubmed/2513189	http://www.ncbi.nlm.nih.gov/pubmed/2513189	NUM
iajs-2271	317	14	.	.	NOUN
iajs-2271	317	15	29	29	NUM
iajs-2271	317	16	.	.	PUNCT
iajs-2271	318	1	koch	koch	PROPN
iajs-2271	318	2	,	,	PUNCT
iajs-2271	318	3	g.l	g.l	PROPN
iajs-2271	318	4	.	.	PROPN
iajs-2271	318	5	;	;	PUNCT
iajs-2271	318	6	shaw	shaw	PROPN
iajs-2271	318	7	,	,	PUNCT
iajs-2271	318	8	d.c	d.c	PROPN
iajs-2271	318	9	.	.	PROPN
iajs-2271	318	10	;	;	PUNCT
iajs-2271	318	11	gibson	gibson	PROPN
iajs-2271	318	12	,	,	PUNCT
iajs-2271	318	13	f.	f.	PROPN
iajs-2271	318	14	tyrosine	tyrosine	PROPN
iajs-2271	318	15	biosynthesis	biosynthesis	VERB
iajs-2271	318	16	in	in	ADP
iajs-2271	318	17	aerobacter	aerobacter	NOUN
iajs-2271	318	18	aerogenes	aerogene	NOUN
iajs-2271	318	19	.	.	PUNCT
iajs-2271	319	1	purification	purification	NOUN
iajs-2271	319	2	and	and	CCONJ
iajs-2271	319	3	properties	property	NOUN
iajs-2271	319	4	of	of	ADP
iajs-2271	319	5	chorismate	chorismate	ADJ
iajs-2271	319	6	mutase	mutase	NOUN
iajs-2271	319	7	-	-	PUNCT
iajs-2271	319	8	prephenate	prephenate	ADJ
iajs-2271	319	9	dehydrogenase	dehydrogenase	NOUN
iajs-2271	319	10	.	.	PUNCT
iajs-2271	320	1	biochim	biochim	PROPN
iajs-2271	320	2	biophys	biophy	VERB
iajs-2271	320	3	acta.1970	acta.1970	PROPN
iajs-2271	320	4	,	,	PUNCT
iajs-2271	320	5	212	212	NUM
iajs-2271	320	6	,	,	PUNCT
iajs-2271	320	7	375	375	NUM
iajs-2271	320	8	-	-	SYM
iajs-2271	320	9	86	86	NUM
iajs-2271	320	10	,	,	PUNCT
iajs-2271	320	11	url	url	NOUN
iajs-2271	320	12	:	:	PUNCT
iajs-2271	320	13	http://www.ncbi.nlm.nih.gov/pubmed/5456988	http://www.ncbi.nlm.nih.gov/pubmed/5456988	NUM
iajs-2271	320	14	.	.	NOUN
iajs-2271	320	15	30	30	NUM
iajs-2271	320	16	.	.	X
iajs-2271	321	1	bezsudnova	bezsudnova	PROPN
iajs-2271	321	2	,	,	PUNCT
iajs-2271	321	3	e.y	e.y	PROPN
iajs-2271	321	4	.	.	PROPN
iajs-2271	321	5	;	;	PUNCT
iajs-2271	321	6	boyko	boyko	PROPN
iajs-2271	321	7	,	,	PUNCT
iajs-2271	321	8	k.m	k.m	PROPN
iajs-2271	321	9	.	.	PROPN
iajs-2271	321	10	;	;	PUNCT
iajs-2271	321	11	popov	popov	PROPN
iajs-2271	321	12	,	,	PUNCT
iajs-2271	321	13	v.o	v.o	PROPN
iajs-2271	321	14	.	.	PROPN
iajs-2271	321	15	properties	property	NOUN
iajs-2271	321	16	of	of	ADP
iajs-2271	321	17	bacterial	bacterial	ADJ
iajs-2271	321	18	and	and	CCONJ
iajs-2271	321	19	archaeal	archaeal	ADJ
iajs-2271	321	20	branched	branch	VERB
iajs-2271	321	21	-	-	PUNCT
iajs-2271	321	22	chain	chain	NOUN
iajs-2271	321	23	amino	amino	NOUN
iajs-2271	321	24	acid	acid	NOUN
iajs-2271	321	25	aminotransferases	aminotransferase	NOUN
iajs-2271	321	26	.	.	PUNCT
iajs-2271	322	1	biochemistry	biochemistry	NOUN
iajs-2271	322	2	(	(	PUNCT
iajs-2271	322	3	mosc).2017	mosc).2017	PROPN
iajs-2271	322	4	,	,	PUNCT
iajs-2271	322	5	82	82	NUM
iajs-2271	322	6	,	,	PUNCT
iajs-2271	322	7	157291	157291	NUM
iajs-2271	322	8	,	,	PUNCT
iajs-2271	322	9	doi	doi	NOUN
iajs-2271	322	10	:	:	PUNCT
iajs-2271	322	11	10.1134	10.1134	NUM
iajs-2271	322	12	/	/	SYM
iajs-2271	322	13	s0006297917130028	s0006297917130028	NOUN
iajs-2271	322	14	.	.	NOUN
iajs-2271	322	15	31	31	NUM
iajs-2271	322	16	.	.	PUNCT
iajs-2271	323	1	nishida	nishida	PROPN
iajs-2271	323	2	,	,	PUNCT
iajs-2271	323	3	h.	h.	PROPN
iajs-2271	323	4	;	;	PUNCT
iajs-2271	323	5	nishiyama	nishiyama	NOUN
iajs-2271	323	6	,	,	PUNCT
iajs-2271	323	7	m.	m.	NOUN
iajs-2271	323	8	;	;	PUNCT
iajs-2271	323	9	kobashi	kobashi	NOUN
iajs-2271	323	10	,	,	PUNCT
iajs-2271	323	11	n.	n.	NOUN
iajs-2271	323	12	;	;	PUNCT
iajs-2271	323	13	kosuge	kosuge	PROPN
iajs-2271	323	14	,	,	PUNCT
iajs-2271	323	15	t.	t.	PROPN
iajs-2271	323	16	;	;	PUNCT
iajs-2271	323	17	hoshino	hoshino	PROPN
iajs-2271	323	18	,	,	PUNCT
iajs-2271	323	19	t.	t.	PROPN
iajs-2271	323	20	;	;	PUNCT
iajs-2271	323	21	yamane	yamane	PROPN
iajs-2271	323	22	,	,	PUNCT
iajs-2271	323	23	h.	h.	PROPN
iajs-2271	323	24	a	a	DET
iajs-2271	323	25	prokaryotic	prokaryotic	ADJ
iajs-2271	323	26	gene	gene	NOUN
iajs-2271	323	27	cluster	cluster	NOUN
iajs-2271	323	28	involved	involve	VERB
iajs-2271	323	29	in	in	ADP
iajs-2271	323	30	synthesis	synthesis	NOUN
iajs-2271	323	31	of	of	ADP
iajs-2271	323	32	lysine	lysine	NOUN
iajs-2271	323	33	through	through	ADP
iajs-2271	323	34	the	the	DET
iajs-2271	323	35	amino	amino	NOUN
iajs-2271	323	36	adipate	adipate	NOUN
iajs-2271	323	37	pathway	pathway	NOUN
iajs-2271	323	38	:	:	PUNCT
iajs-2271	323	39	a	a	DET
iajs-2271	323	40	key	key	NOUN
iajs-2271	323	41	to	to	ADP
iajs-2271	323	42	the	the	DET
iajs-2271	323	43	evolution	evolution	NOUN
iajs-2271	323	44	of	of	ADP
iajs-2271	323	45	amino	amino	NOUN
iajs-2271	323	46	acid	acid	NOUN
iajs-2271	323	47	biosynthesis	biosynthesis	NOUN
iajs-2271	323	48	.	.	PUNCT
iajs-2271	324	1	genome	genome	NOUN
iajs-2271	324	2	res.1999	res.1999	NOUN
iajs-2271	324	3	,	,	PUNCT
iajs-2271	324	4	9	9	NUM
iajs-2271	324	5	,	,	PUNCT
iajs-2271	324	6	117583	117583	NUM
iajs-2271	324	7	,	,	PUNCT
iajs-2271	324	8	url	url	PROPN
iajs-2271	324	9	:	:	PUNCT
iajs-2271	324	10	http://www.ncbi.nlm.nih.gov/pubmed/10613839	http://www.ncbi.nlm.nih.gov/pubmed/10613839	NUM
iajs-2271	324	11	.	.	NOUN
iajs-2271	325	1	18	18	NUM
iajs-2271	325	2	ibn	ibn	PROPN
iajs-2271	325	3	al	al	PROPN
iajs-2271	325	4	-	-	PUNCT
iajs-2271	325	5	haitham	haitham	PROPN
iajs-2271	325	6	jour	jour	X
iajs-2271	325	7	.	.	PROPN
iajs-2271	325	8	for	for	ADP
iajs-2271	325	9	pure	pure	ADJ
iajs-2271	325	10	&	&	CCONJ
iajs-2271	325	11	appl	appl	PROPN
iajs-2271	325	12	.	.	PUNCT
iajs-2271	326	1	sci	sci	PROPN
iajs-2271	326	2	.	.	PROPN
iajs-2271	326	3	32	32	NUM
iajs-2271	326	4	(	(	PUNCT
iajs-2271	326	5	3	3	NUM
iajs-2271	326	6	)	)	PUNCT
iajs-2271	326	7	2019	2019	NUM
iajs-2271	326	8	32	32	NUM
iajs-2271	326	9	.	.	PUNCT
iajs-2271	327	1	lombo	lombo	PROPN
iajs-2271	327	2	,	,	PUNCT
iajs-2271	327	3	t.	t.	PROPN
iajs-2271	327	4	;	;	PUNCT
iajs-2271	327	5	takaya	takaya	PROPN
iajs-2271	327	6	,	,	PUNCT
iajs-2271	327	7	n.	n.	PROPN
iajs-2271	327	8	;	;	PUNCT
iajs-2271	327	9	miyazaki	miyazaki	PROPN
iajs-2271	327	10	,	,	PUNCT
iajs-2271	327	11	j.	j.	PROPN
iajs-2271	327	12	;	;	PUNCT
iajs-2271	327	13	gotoh	gotoh	PROPN
iajs-2271	327	14	,	,	PUNCT
iajs-2271	327	15	k.	k.	PROPN
iajs-2271	327	16	;	;	PUNCT
iajs-2271	327	17	nishiyama	nishiyama	NOUN
iajs-2271	327	18	,	,	PUNCT
iajs-2271	327	19	m.	m.	NOUN
iajs-2271	327	20	;	;	PUNCT
iajs-2271	327	21	et	et	PROPN
iajs-2271	327	22	al	al	PROPN
iajs-2271	327	23	.	.	PROPN
iajs-2271	327	24	functional	functional	ADJ
iajs-2271	327	25	analysis	analysis	NOUN
iajs-2271	327	26	of	of	ADP
iajs-2271	327	27	the	the	DET
iajs-2271	327	28	small	small	ADJ
iajs-2271	327	29	subunit	subunit	NOUN
iajs-2271	327	30	of	of	ADP
iajs-2271	327	31	the	the	DET
iajs-2271	327	32	putative	putative	ADJ
iajs-2271	327	33	homoaconitase	homoaconitase	NOUN
iajs-2271	327	34	from	from	ADP
iajs-2271	327	35	pyrococcus	pyrococcus	ADJ
iajs-2271	327	36	horikoshii	horikoshii	PROPN
iajs-2271	327	37	in	in	ADP
iajs-2271	327	38	the	the	DET
iajs-2271	327	39	thermus	thermus	NOUN
iajs-2271	327	40	lysine	lysine	NOUN
iajs-2271	327	41	biosynthetic	biosynthetic	ADJ
iajs-2271	327	42	pathway	pathway	NOUN
iajs-2271	327	43	.	.	PUNCT
iajs-2271	328	1	fems	fems	PROPN
iajs-2271	328	2	microbiol	microbiol	PROPN
iajs-2271	328	3	lett.2004	lett.2004	PROPN
iajs-2271	328	4	,	,	PUNCT
iajs-2271	328	5	233	233	NUM
iajs-2271	328	6	,	,	PUNCT
iajs-2271	328	7	315	315	NUM
iajs-2271	328	8	-	-	SYM
iajs-2271	328	9	24	24	NUM
iajs-2271	328	10	,	,	PUNCT
iajs-2271	328	11	doi	doi	NOUN
iajs-2271	328	12	:	:	PUNCT
iajs-2271	328	13	10.1016	10.1016	NUM
iajs-2271	328	14	/	/	SYM
iajs-2271	328	15	j.femsle.2004.02.026	j.femsle.2004.02.026	PROPN
iajs-2271	328	16	.	.	PUNCT
iajs-2271	329	1	33	33	NUM
iajs-2271	329	2	.	.	PUNCT
iajs-2271	330	1	miyazaki	miyazaki	PROPN
iajs-2271	330	2	,	,	PUNCT
iajs-2271	330	3	t.	t.	PROPN
iajs-2271	330	4	;	;	PUNCT
iajs-2271	330	5	miyazaki	miyazaki	PROPN
iajs-2271	330	6	,	,	PUNCT
iajs-2271	330	7	j.	j.	PROPN
iajs-2271	330	8	;	;	PUNCT
iajs-2271	330	9	yamane	yamane	PROPN
iajs-2271	330	10	,	,	PUNCT
iajs-2271	330	11	h.	h.	PROPN
iajs-2271	330	12	;	;	PUNCT
iajs-2271	330	13	nishiyama	nishiyama	NOUN
iajs-2271	330	14	,	,	PUNCT
iajs-2271	330	15	m.	m.	NOUN
iajs-2271	330	16	alpha	alpha	NOUN
iajs-2271	330	17	-	-	PUNCT
iajs-2271	330	18	aminoadipate	aminoadipate	NOUN
iajs-2271	330	19	aminotransferase	aminotransferase	NOUN
iajs-2271	330	20	from	from	ADP
iajs-2271	330	21	an	an	DET
iajs-2271	330	22	extremely	extremely	ADV
iajs-2271	330	23	thermophilic	thermophilic	ADJ
iajs-2271	330	24	bacterium	bacterium	NOUN
iajs-2271	330	25	,	,	PUNCT
iajs-2271	330	26	thermus	thermus	NOUN
iajs-2271	330	27	thermophilus	thermophilus	NOUN
iajs-2271	330	28	.	.	PUNCT
iajs-2271	331	1	microbiology.2004	microbiology.2004	NOUN
iajs-2271	331	2	,	,	PUNCT
iajs-2271	331	3	150	150	NUM
iajs-2271	331	4	,	,	PUNCT
iajs-2271	331	5	232734	232734	NUM
iajs-2271	331	6	,	,	PUNCT
iajs-2271	331	7	doi	doi	NOUN
iajs-2271	331	8	:	:	PUNCT
iajs-2271	331	9	10.1099	10.1099	NUM
iajs-2271	331	10	/	/	SYM
iajs-2271	331	11	mic.0.27037	mic.0.27037	NOUN
iajs-2271	331	12	-	-	PUNCT
iajs-2271	331	13	0	0	NUM
iajs-2271	331	14	.	.	PUNCT
iajs-2271	332	1	34	34	NUM
iajs-2271	332	2	.	.	PUNCT
iajs-2271	332	3	marino	marino	PROPN
iajs-2271	332	4	,	,	PUNCT
iajs-2271	332	5	g.	g.	PROPN
iajs-2271	332	6	;	;	PUNCT
iajs-2271	332	7	nitti	nitti	PROPN
iajs-2271	332	8	,	,	PUNCT
iajs-2271	332	9	g.	g.	PROPN
iajs-2271	332	10	;	;	PUNCT
iajs-2271	332	11	arnone	arnone	NOUN
iajs-2271	332	12	,	,	PUNCT
iajs-2271	332	13	m.i	m.i	PROPN
iajs-2271	332	14	.	.	PROPN
iajs-2271	332	15	;	;	PUNCT
iajs-2271	332	16	sannia	sannia	PROPN
iajs-2271	332	17	,	,	PUNCT
iajs-2271	332	18	g.	g.	PROPN
iajs-2271	332	19	;	;	PUNCT
iajs-2271	332	20	gambacorta	gambacorta	PROPN
iajs-2271	332	21	,	,	PUNCT
iajs-2271	332	22	a.	a.	NOUN
iajs-2271	332	23	;	;	PUNCT
iajs-2271	332	24	de	de	PROPN
iajs-2271	332	25	rosa	rosa	PROPN
iajs-2271	332	26	,	,	PUNCT
iajs-2271	332	27	m.	m.	NOUN
iajs-2271	332	28	purification	purification	NOUN
iajs-2271	332	29	and	and	CCONJ
iajs-2271	332	30	characterization	characterization	NOUN
iajs-2271	332	31	of	of	ADP
iajs-2271	332	32	aspartate	aspartate	NOUN
iajs-2271	332	33	aminotransferase	aminotransferase	NOUN
iajs-2271	332	34	from	from	ADP
iajs-2271	332	35	the	the	DET
iajs-2271	332	36	thermoacidophilic	thermoacidophilic	NOUN
iajs-2271	332	37	archaebacterium	archaebacterium	NOUN
iajs-2271	332	38	sulfolobus	sulfolobus	NOUN
iajs-2271	332	39	solfataricus	solfataricus	NOUN
iajs-2271	332	40	.	.	PUNCT
iajs-2271	333	1	j	j	PROPN
iajs-2271	333	2	biol	biol	PROPN
iajs-2271	333	3	chem.1988	chem.1988	PROPN
iajs-2271	333	4	,	,	PUNCT
iajs-2271	333	5	263	263	NUM
iajs-2271	333	6	,	,	PUNCT
iajs-2271	333	7	12305	12305	NUM
iajs-2271	333	8	-	-	SYM
iajs-2271	333	9	9	9	NUM
iajs-2271	333	10	,	,	PUNCT
iajs-2271	333	11	url	url	NOUN
iajs-2271	333	12	:	:	PUNCT
iajs-2271	333	13	http://www.ncbi.nlm.nih.gov/pubmed/3137225	http://www.ncbi.nlm.nih.gov/pubmed/3137225	NOUN
iajs-2271	333	14	.	.	PROPN
iajs-2271	333	15	35	35	NUM
iajs-2271	333	16	.	.	PUNCT
iajs-2271	334	1	xing	xing	PROPN
iajs-2271	334	2	,	,	PUNCT
iajs-2271	334	3	r.y	r.y	PROPN
iajs-2271	334	4	.	.	PROPN
iajs-2271	334	5	;	;	PUNCT
iajs-2271	334	6	whitman	whitman	PROPN
iajs-2271	334	7	,	,	PUNCT
iajs-2271	334	8	w.b	w.b	PROPN
iajs-2271	334	9	.	.	PROPN
iajs-2271	334	10	characterization	characterization	NOUN
iajs-2271	334	11	of	of	ADP
iajs-2271	334	12	amino	amino	NOUN
iajs-2271	334	13	acid	acid	NOUN
iajs-2271	334	14	aminotransferases	aminotransferase	NOUN
iajs-2271	334	15	of	of	ADP
iajs-2271	334	16	methanococcus	methanococcus	NOUN
iajs-2271	334	17	aeolicus	aeolicus	ADJ
iajs-2271	334	18	.	.	PUNCT
iajs-2271	335	1	j	j	PROPN
iajs-2271	335	2	bacteriol	bacteriol	NOUN
iajs-2271	335	3	.	.	PUNCT
iajs-2271	336	1	1992	1992	NUM
iajs-2271	336	2	,	,	PUNCT
iajs-2271	336	3	174	174	NUM
iajs-2271	336	4	,	,	PUNCT
iajs-2271	336	5	541	541	NUM
iajs-2271	336	6	-	-	SYM
iajs-2271	336	7	8	8	NUM
iajs-2271	336	8	,	,	PUNCT
iajs-2271	336	9	url	url	NOUN
iajs-2271	336	10	:	:	PUNCT
iajs-2271	336	11	http://www.ncbi.nlm.nih.gov/pubmed/1729242	http://www.ncbi.nlm.nih.gov/pubmed/1729242	PROPN
iajs-2271	336	12	.	.	PROPN
iajs-2271	336	13	36	36	NUM
iajs-2271	336	14	.	.	PUNCT
iajs-2271	337	1	charlebois	charlebois	PROPN
iajs-2271	337	2	,	,	PUNCT
iajs-2271	337	3	r.l	r.l	PROPN
iajs-2271	337	4	.	.	PROPN
iajs-2271	337	5	;	;	PUNCT
iajs-2271	337	6	sensen	sensen	PROPN
iajs-2271	337	7	,	,	PUNCT
iajs-2271	337	8	c.w	c.w	PROPN
iajs-2271	337	9	.	.	PROPN
iajs-2271	337	10	;	;	PUNCT
iajs-2271	337	11	doolittle	doolittle	PROPN
iajs-2271	337	12	,	,	PUNCT
iajs-2271	337	13	w.f	w.f	PROPN
iajs-2271	337	14	.	.	PROPN
iajs-2271	337	15	;	;	PUNCT
iajs-2271	337	16	brown	brown	PROPN
iajs-2271	337	17	,	,	PUNCT
iajs-2271	337	18	j.r	j.r	PROPN
iajs-2271	337	19	.	.	PROPN
iajs-2271	337	20	evolutionary	evolutionary	ADJ
iajs-2271	337	21	analysis	analysis	NOUN
iajs-2271	337	22	of	of	ADP
iajs-2271	337	23	the	the	DET
iajs-2271	337	24	hiscgabdfdehi	hiscgabdfdehi	ADJ
iajs-2271	337	25	gene	gene	NOUN
iajs-2271	337	26	cluster	cluster	NOUN
iajs-2271	337	27	from	from	ADP
iajs-2271	337	28	the	the	DET
iajs-2271	337	29	archaeon	archaeon	NOUN
iajs-2271	337	30	sulfolobus	sulfolobus	NOUN
iajs-2271	337	31	solfataricus	solfataricus	NOUN
iajs-2271	337	32	p2.j	p2.j	PROPN
iajs-2271	337	33	bacteriol.1997	bacteriol.1997	PROPN
iajs-2271	337	34	,	,	PUNCT
iajs-2271	337	35	179	179	NUM
iajs-2271	337	36	,	,	PUNCT
iajs-2271	337	37	4429	4429	NUM
iajs-2271	337	38	-	-	SYM
iajs-2271	337	39	32	32	NUM
iajs-2271	337	40	,	,	PUNCT
iajs-2271	337	41	url	url	NOUN
iajs-2271	337	42	:	:	PUNCT
iajs-2271	337	43	http://www.ncbi.nlm.nih.gov/pubmed/9209067	http://www.ncbi.nlm.nih.gov/pubmed/9209067	NUM
iajs-2271	337	44	.	.	PUNCT