id	sid	tid	token	lemma	pos
iajs-3642	1	1	313	313	NUM
iajs-3642	1	2	©	©	PROPN
iajs-3642	1	3	2025	2025	NUM
iajs-3642	1	4	the	the	DET
iajs-3642	1	5	author(s	author(s	NOUN
iajs-3642	1	6	)	)	PUNCT
iajs-3642	1	7	.	.	PUNCT
iajs-3642	2	1	published	publish	VERB
iajs-3642	2	2	by	by	ADP
iajs-3642	2	3	college	college	NOUN
iajs-3642	2	4	of	of	ADP
iajs-3642	2	5	education	education	NOUN
iajs-3642	2	6	for	for	ADP
iajs-3642	2	7	pure	pure	ADJ
iajs-3642	2	8	science	science	NOUN
iajs-3642	2	9	(	(	PUNCT
iajs-3642	2	10	ibn	ibn	PROPN
iajs-3642	2	11	al	al	PROPN
iajs-3642	2	12	-	-	PUNCT
iajs-3642	2	13	haitham	haitham	PROPN
iajs-3642	2	14	)	)	PUNCT
iajs-3642	2	15	,	,	PUNCT
iajs-3642	2	16	university	university	NOUN
iajs-3642	2	17	of	of	ADP
iajs-3642	2	18	baghdad	baghdad	PROPN
iajs-3642	2	19	.	.	PUNCT
iajs-3642	3	1	this	this	PRON
iajs-3642	3	2	is	be	AUX
iajs-3642	3	3	an	an	DET
iajs-3642	3	4	open	open	ADJ
iajs-3642	3	5	-	-	PUNCT
iajs-3642	3	6	access	access	NOUN
iajs-3642	3	7	article	article	NOUN
iajs-3642	3	8	distributed	distribute	VERB
iajs-3642	3	9	under	under	ADP
iajs-3642	3	10	the	the	DET
iajs-3642	3	11	terms	term	NOUN
iajs-3642	3	12	of	of	ADP
iajs-3642	3	13	the	the	DET
iajs-3642	3	14	creative	creative	ADJ
iajs-3642	3	15	commons	common	NOUN
iajs-3642	3	16	attribution	attribution	NOUN
iajs-3642	3	17	4.0	4.0	NUM
iajs-3642	3	18	international	international	ADJ
iajs-3642	3	19	license	license	NOUN
iajs-3642	3	20	synthesis	synthesis	NOUN
iajs-3642	3	21	,	,	PUNCT
iajs-3642	3	22	characterization	characterization	NOUN
iajs-3642	3	23	,	,	PUNCT
iajs-3642	3	24	molecular	molecular	ADJ
iajs-3642	3	25	docking	docking	NOUN
iajs-3642	3	26	,	,	PUNCT
iajs-3642	3	27	and	and	CCONJ
iajs-3642	3	28	in	in	ADP
iajs-3642	3	29	silico	silico	NOUN
iajs-3642	3	30	adme	adme	NOUN
iajs-3642	3	31	study	study	VERB
iajs-3642	3	32	for	for	ADP
iajs-3642	3	33	some	some	DET
iajs-3642	3	34	new	new	ADJ
iajs-3642	3	35	different	different	ADJ
iajs-3642	3	36	derivatives	derivative	NOUN
iajs-3642	3	37	for	for	ADP
iajs-3642	3	38	succiniohydrazide	succiniohydrazide	PROPN
iajs-3642	3	39	asmaa	asmaa	PROPN
iajs-3642	3	40	a.	a.	NOUN
iajs-3642	3	41	maryoosh1	maryoosh1	PROPN
iajs-3642	3	42	*	*	PUNCT
iajs-3642	3	43	and	and	CCONJ
iajs-3642	3	44	oday	oday	PROPN
iajs-3642	3	45	h.	h.	PROPN
iajs-3642	3	46	r.	r.	PROPN
iajs-3642	3	47	al	al	PROPN
iajs-3642	3	48	-	-	PUNCT
iajs-3642	3	49	jeilawi2	jeilawi2	PROPN
iajs-3642	3	50	1department	1department	NUM
iajs-3642	3	51	of	of	ADP
iajs-3642	3	52	chemistry	chemistry	NOUN
iajs-3642	3	53	,	,	PUNCT
iajs-3642	3	54	college	college	NOUN
iajs-3642	3	55	of	of	ADP
iajs-3642	3	56	science	science	NOUN
iajs-3642	3	57	,	,	PUNCT
iajs-3642	3	58	mustansiriyah	mustansiriyah	NOUN
iajs-3642	3	59	university	university	NOUN
iajs-3642	3	60	,	,	PUNCT
iajs-3642	3	61	baghdad	baghdad	PROPN
iajs-3642	3	62	,	,	PUNCT
iajs-3642	3	63	iraq	iraq	PROPN
iajs-3642	3	64	.	.	PUNCT
iajs-3642	4	1	1,2	1,2	NUM
iajs-3642	4	2	department	department	NOUN
iajs-3642	4	3	of	of	ADP
iajs-3642	4	4	chemistry	chemistry	NOUN
iajs-3642	4	5	,	,	PUNCT
iajs-3642	4	6	college	college	NOUN
iajs-3642	4	7	of	of	ADP
iajs-3642	4	8	sciences	science	NOUN
iajs-3642	4	9	,	,	PUNCT
iajs-3642	4	10	university	university	NOUN
iajs-3642	4	11	of	of	ADP
iajs-3642	4	12	baghdad	baghdad	PROPN
iajs-3642	4	13	,	,	PUNCT
iajs-3642	4	14	baghdad	baghdad	PROPN
iajs-3642	4	15	,	,	PUNCT
iajs-3642	4	16	iraq	iraq	PROPN
iajs-3642	4	17	.	.	PUNCT
iajs-3642	5	1	*	*	PUNCT
iajs-3642	5	2	corresponding	correspond	VERB
iajs-3642	5	3	author	author	NOUN
iajs-3642	5	4	.	.	PUNCT
iajs-3642	6	1	received	receive	VERB
iajs-3642	6	2	:	:	PUNCT
iajs-3642	6	3	2	2	NUM
iajs-3642	6	4	july	july	PROPN
iajs-3642	6	5	2023	2023	NUM
iajs-3642	6	6	accepted	accept	VERB
iajs-3642	6	7	:	:	PUNCT
iajs-3642	6	8	27	27	NUM
iajs-3642	6	9	august	august	PROPN
iajs-3642	6	10	2023	2023	NUM
iajs-3642	6	11	published	publish	VERB
iajs-3642	6	12	:	:	PUNCT
iajs-3642	6	13	20	20	NUM
iajs-3642	6	14	january	january	NOUN
iajs-3642	6	15	2025	2025	NUM
iajs-3642	6	16	doi.org/10.30526/38.1.3642	doi.org/10.30526/38.1.3642	NOUN
iajs-3642	6	17	abstract	abstract	ADJ
iajs-3642	6	18	many	many	ADJ
iajs-3642	6	19	studies	study	NOUN
iajs-3642	6	20	have	have	AUX
iajs-3642	6	21	found	find	VERB
iajs-3642	6	22	effective	effective	ADJ
iajs-3642	6	23	oral	oral	ADJ
iajs-3642	6	24	influenza	influenza	NOUN
iajs-3642	6	25	virus	virus	NOUN
iajs-3642	6	26	inhibitors	inhibitor	NOUN
iajs-3642	6	27	based	base	VERB
iajs-3642	6	28	on	on	ADP
iajs-3642	6	29	an	an	DET
iajs-3642	6	30	aryl	aryl	NOUN
iajs-3642	6	31	benzoyl	benzoyl	NOUN
iajs-3642	6	32	hydrazide	hydrazide	ADJ
iajs-3642	6	33	scaffold	scaffold	NOUN
iajs-3642	6	34	and	and	CCONJ
iajs-3642	6	35	antiviral	antiviral	NOUN
iajs-3642	6	36	.	.	PUNCT
iajs-3642	7	1	this	this	DET
iajs-3642	7	2	study	study	NOUN
iajs-3642	7	3	aims	aim	VERB
iajs-3642	7	4	to	to	PART
iajs-3642	7	5	prepare	prepare	VERB
iajs-3642	7	6	a	a	DET
iajs-3642	7	7	new	new	ADJ
iajs-3642	7	8	series	series	NOUN
iajs-3642	7	9	of	of	ADP
iajs-3642	7	10	derivatives	derivative	NOUN
iajs-3642	7	11	containing	contain	VERB
iajs-3642	7	12	succinohydrazide	succinohydrazide	ADV
iajs-3642	7	13	as	as	ADP
iajs-3642	7	14	a	a	DET
iajs-3642	7	15	precursor	precursor	NOUN
iajs-3642	7	16	.	.	PUNCT
iajs-3642	8	1	in	in	ADP
iajs-3642	8	2	the	the	DET
iajs-3642	8	3	first	first	ADJ
iajs-3642	8	4	step	step	NOUN
iajs-3642	8	5	,	,	PUNCT
iajs-3642	8	6	after	after	ADP
iajs-3642	8	7	synthesis	synthesis	NOUN
iajs-3642	8	8	of	of	ADP
iajs-3642	8	9	their	their	PRON
iajs-3642	8	10	precursor	precursor	NOUN
iajs-3642	8	11	,	,	PUNCT
iajs-3642	8	12	it	it	PRON
iajs-3642	8	13	has	have	AUX
iajs-3642	8	14	been	be	AUX
iajs-3642	8	15	prepared	prepare	VERB
iajs-3642	8	16	di	di	X
iajs-3642	8	17	benzoyl	benzoyl	PROPN
iajs-3642	8	18	succinohydrazide	succinohydrazide	NOUN
iajs-3642	8	19	using	use	VERB
iajs-3642	8	20	a	a	DET
iajs-3642	8	21	two	two	NUM
iajs-3642	8	22	-	-	PUNCT
iajs-3642	8	23	step	step	NOUN
iajs-3642	8	24	process	process	NOUN
iajs-3642	8	25	that	that	PRON
iajs-3642	8	26	involved	involve	VERB
iajs-3642	8	27	reacting	react	VERB
iajs-3642	8	28	(	(	PUNCT
iajs-3642	8	29	o	o	NOUN
iajs-3642	8	30	,	,	PUNCT
iajs-3642	8	31	m	m	PROPN
iajs-3642	8	32	,	,	PUNCT
iajs-3642	8	33	p)-chloro	p)-chloro	NOUN
iajs-3642	8	34	benzoic	benzoic	NOUN
iajs-3642	8	35	acid	acid	NOUN
iajs-3642	8	36	with	with	ADP
iajs-3642	8	37	thionyl	thionyl	ADJ
iajs-3642	8	38	chloride	chloride	NOUN
iajs-3642	8	39	to	to	PART
iajs-3642	8	40	obtain	obtain	VERB
iajs-3642	8	41	freshly	freshly	ADV
iajs-3642	8	42	prepared	prepare	VERB
iajs-3642	8	43	substituted	substitute	VERB
iajs-3642	8	44	benzoyl	benzoyl	NOUN
iajs-3642	8	45	chloride	chloride	NOUN
iajs-3642	8	46	derivatives	derivative	NOUN
iajs-3642	8	47	that	that	PRON
iajs-3642	8	48	were	be	AUX
iajs-3642	8	49	then	then	ADV
iajs-3642	8	50	reacted	react	VERB
iajs-3642	8	51	with	with	ADP
iajs-3642	8	52	succinohydrazide	succinohydrazide	ADJ
iajs-3642	8	53	,	,	PUNCT
iajs-3642	8	54	or	or	CCONJ
iajs-3642	8	55	by	by	ADP
iajs-3642	8	56	a	a	DET
iajs-3642	8	57	second	second	ADJ
iajs-3642	8	58	method	method	NOUN
iajs-3642	8	59	,	,	PUNCT
iajs-3642	8	60	directly	directly	ADV
iajs-3642	8	61	reacting	react	VERB
iajs-3642	8	62	substituted	substitute	VERB
iajs-3642	8	63	benzoyl	benzoyl	NOUN
iajs-3642	8	64	chloride	chloride	NOUN
iajs-3642	8	65	with	with	ADP
iajs-3642	8	66	succinohydrazide	succinohydrazide	NOUN
iajs-3642	8	67	to	to	PART
iajs-3642	8	68	give	give	VERB
iajs-3642	8	69	benzoylsuccinohydrazide	benzoylsuccinohydrazide	ADP
iajs-3642	8	70	derivatives	derivative	NOUN
iajs-3642	8	71	.	.	PUNCT
iajs-3642	9	1	after	after	ADP
iajs-3642	9	2	that	that	PRON
iajs-3642	9	3	,	,	PUNCT
iajs-3642	9	4	different	different	ADJ
iajs-3642	9	5	derivatives	derivative	NOUN
iajs-3642	9	6	were	be	AUX
iajs-3642	9	7	prepared	prepare	VERB
iajs-3642	9	8	involving	involve	VERB
iajs-3642	9	9	the	the	DET
iajs-3642	9	10	reaction	reaction	NOUN
iajs-3642	9	11	of	of	ADP
iajs-3642	9	12	succinohydrazide	succinohydrazide	ADJ
iajs-3642	9	13	with	with	ADP
iajs-3642	9	14	substituted	substitute	VERB
iajs-3642	9	15	benzene	benzene	NOUN
iajs-3642	9	16	sulphonyl	sulphonyl	NOUN
iajs-3642	9	17	chloride	chloride	NOUN
iajs-3642	9	18	,	,	PUNCT
iajs-3642	9	19	benzyl	benzyl	NOUN
iajs-3642	9	20	chloride	chloride	NOUN
iajs-3642	9	21	,	,	PUNCT
iajs-3642	9	22	and	and	CCONJ
iajs-3642	9	23	phenacyl	phenacyl	VERB
iajs-3642	9	24	chloride	chloride	NOUN
iajs-3642	9	25	.	.	PUNCT
iajs-3642	10	1	ftir	ftir	PROPN
iajs-3642	10	2	,	,	PUNCT
iajs-3642	10	3	1hnmr	1hnmr	NUM
iajs-3642	10	4	,	,	PUNCT
iajs-3642	10	5	and	and	CCONJ
iajs-3642	10	6	13cnmr	13cnmr	NUM
iajs-3642	10	7	spectra	spectra	PROPN
iajs-3642	10	8	have	have	AUX
iajs-3642	10	9	been	be	AUX
iajs-3642	10	10	used	use	VERB
iajs-3642	10	11	to	to	PART
iajs-3642	10	12	verify	verify	VERB
iajs-3642	10	13	the	the	DET
iajs-3642	10	14	structures	structure	NOUN
iajs-3642	10	15	of	of	ADP
iajs-3642	10	16	newly	newly	ADV
iajs-3642	10	17	synthesized	synthesize	VERB
iajs-3642	10	18	compounds	compound	NOUN
iajs-3642	10	19	.	.	PUNCT
iajs-3642	11	1	the	the	DET
iajs-3642	11	2	swiss	swiss	ADJ
iajs-3642	11	3	adme	adme	NOUN
iajs-3642	11	4	method	method	NOUN
iajs-3642	11	5	with	with	ADP
iajs-3642	11	6	boiled	boil	VERB
iajs-3642	11	7	egg	egg	NOUN
iajs-3642	11	8	prediction	prediction	NOUN
iajs-3642	11	9	was	be	AUX
iajs-3642	11	10	used	use	VERB
iajs-3642	11	11	to	to	PART
iajs-3642	11	12	analyze	analyze	VERB
iajs-3642	11	13	its	its	PRON
iajs-3642	11	14	pharmacokinetic	pharmacokinetic	ADJ
iajs-3642	11	15	properties	property	NOUN
iajs-3642	11	16	.	.	PUNCT
iajs-3642	12	1	then	then	ADV
iajs-3642	12	2	,	,	PUNCT
iajs-3642	12	3	genetic	genetic	ADJ
iajs-3642	12	4	optimization	optimization	NOUN
iajs-3642	12	5	of	of	ADP
iajs-3642	12	6	linkage	linkage	NOUN
iajs-3642	12	7	docking	docking	NOUN
iajs-3642	12	8	(	(	PUNCT
iajs-3642	12	9	gold	gold	NOUN
iajs-3642	12	10	)	)	PUNCT
iajs-3642	12	11	was	be	AUX
iajs-3642	12	12	used	use	VERB
iajs-3642	12	13	in	in	ADP
iajs-3642	12	14	theoretical	theoretical	ADJ
iajs-3642	12	15	studies	study	NOUN
iajs-3642	12	16	to	to	PART
iajs-3642	12	17	investigate	investigate	VERB
iajs-3642	12	18	the	the	DET
iajs-3642	12	19	binding	bind	VERB
iajs-3642	12	20	mechanism	mechanism	NOUN
iajs-3642	12	21	of	of	ADP
iajs-3642	12	22	the	the	DET
iajs-3642	12	23	protein	protein	NOUN
iajs-3642	12	24	-	-	PUNCT
iajs-3642	12	25	ligand	ligand	NOUN
iajs-3642	12	26	produced	produce	VERB
iajs-3642	12	27	with	with	ADP
iajs-3642	12	28	the	the	DET
iajs-3642	12	29	protein	protein	NOUN
iajs-3642	12	30	(	(	PUNCT
iajs-3642	12	31	1sa0	1sa0	NUM
iajs-3642	12	32	)	)	PUNCT
iajs-3642	12	33	.	.	PUNCT
iajs-3642	13	1	among	among	ADP
iajs-3642	13	2	all	all	DET
iajs-3642	13	3	synthesis	synthesis	NOUN
iajs-3642	13	4	compounds	compound	NOUN
iajs-3642	13	5	,	,	PUNCT
iajs-3642	13	6	compound	compound	NOUN
iajs-3642	13	7	2b	2b	NUM
iajs-3642	13	8	has	have	VERB
iajs-3642	13	9	excellent	excellent	ADJ
iajs-3642	13	10	results	result	NOUN
iajs-3642	13	11	compared	compare	VERB
iajs-3642	13	12	with	with	ADP
iajs-3642	13	13	colchicine	colchicine	NOUN
iajs-3642	13	14	and	and	CCONJ
iajs-3642	13	15	can	can	AUX
iajs-3642	13	16	be	be	AUX
iajs-3642	13	17	considered	consider	VERB
iajs-3642	13	18	a	a	DET
iajs-3642	13	19	good	good	ADJ
iajs-3642	13	20	antibacterial	antibacterial	NOUN
iajs-3642	13	21	against	against	ADP
iajs-3642	13	22	escherichia	escherichia	NOUN
iajs-3642	13	23	coli	coli	NOUN
iajs-3642	13	24	and	and	CCONJ
iajs-3642	13	25	an	an	DET
iajs-3642	13	26	anti	anti	ADJ
iajs-3642	13	27	-	-	ADJ
iajs-3642	13	28	breast	breast	ADJ
iajs-3642	13	29	cancer	cancer	NOUN
iajs-3642	13	30	drug	drug	NOUN
iajs-3642	13	31	.	.	PUNCT
iajs-3642	14	1	keywords	keyword	NOUN
iajs-3642	14	2	:	:	PUNCT
iajs-3642	14	3	adme	adme	NOUN
iajs-3642	14	4	,	,	PUNCT
iajs-3642	14	5	benzohydrazide	benzohydrazide	VERB
iajs-3642	14	6	,	,	PUNCT
iajs-3642	14	7	benzylhydrazide	benzylhydrazide	ADJ
iajs-3642	14	8	,	,	PUNCT
iajs-3642	14	9	lipinsky	lipinsky	ADJ
iajs-3642	14	10	rule	rule	NOUN
iajs-3642	14	11	,	,	PUNCT
iajs-3642	14	12	molecular	molecular	ADJ
iajs-3642	14	13	docking	docking	NOUN
iajs-3642	14	14	,	,	PUNCT
iajs-3642	14	15	sulfonohydrazide	sulfonohydrazide	NOUN
iajs-3642	14	16	,	,	PUNCT
iajs-3642	14	17	1	1	NUM
iajs-3642	14	18	.	.	PUNCT
iajs-3642	15	1	introduction	introduction	NOUN
iajs-3642	15	2	microtubules	microtubule	NOUN
iajs-3642	15	3	(	(	PUNCT
iajs-3642	15	4	α	α	NOUN
iajs-3642	15	5	,	,	PUNCT
iajs-3642	15	6	β	β	NOUN
iajs-3642	15	7	-	-	PUNCT
iajs-3642	15	8	tubulin	tubulin	NOUN
iajs-3642	15	9	heterodimers	heterodimer	NOUN
iajs-3642	15	10	)	)	PUNCT
iajs-3642	15	11	are	be	AUX
iajs-3642	15	12	essential	essential	ADJ
iajs-3642	15	13	components	component	NOUN
iajs-3642	15	14	of	of	ADP
iajs-3642	15	15	eukaryotic	eukaryotic	ADJ
iajs-3642	15	16	cell	cell	NOUN
iajs-3642	15	17	structure	structure	NOUN
iajs-3642	15	18	and	and	CCONJ
iajs-3642	15	19	play	play	VERB
iajs-3642	15	20	important	important	ADJ
iajs-3642	15	21	roles	role	NOUN
iajs-3642	15	22	in	in	ADP
iajs-3642	15	23	a	a	DET
iajs-3642	15	24	variety	variety	NOUN
iajs-3642	15	25	of	of	ADP
iajs-3642	15	26	cellular	cellular	ADJ
iajs-3642	15	27	processes	process	NOUN
iajs-3642	15	28	,	,	PUNCT
iajs-3642	15	29	including	include	VERB
iajs-3642	15	30	cell	cell	NOUN
iajs-3642	15	31	shape	shape	NOUN
iajs-3642	15	32	determination	determination	NOUN
iajs-3642	15	33	and	and	CCONJ
iajs-3642	15	34	repair	repair	NOUN
iajs-3642	15	35	,	,	PUNCT
iajs-3642	15	36	motility	motility	NOUN
iajs-3642	15	37	regulation	regulation	NOUN
iajs-3642	15	38	,	,	PUNCT
iajs-3642	15	39	intracellular	intracellular	ADJ
iajs-3642	15	40	building	building	NOUN
iajs-3642	15	41	organization	organization	NOUN
iajs-3642	15	42	,	,	PUNCT
iajs-3642	15	43	secretion	secretion	NOUN
iajs-3642	15	44	,	,	PUNCT
iajs-3642	15	45	cellular	cellular	ADJ
iajs-3642	15	46	transport	transport	NOUN
iajs-3642	15	47	,	,	PUNCT
iajs-3642	15	48	and	and	CCONJ
iajs-3642	15	49	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
iajs-3642	15	50	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
iajs-3642	15	51	https://orcid.org/0000-0002-4970-6675	https://orcid.org/0000-0002-4970-6675	PROPN
iajs-3642	15	52	mailto:asmaa.abd2105m@sc.uobaghdad.edu.iq	mailto:asmaa.abd2105m@sc.uobaghdad.edu.iq	PROPN
iajs-3642	15	53	https://orcid.org/0000-0002-4092-2072	https://orcid.org/0000-0002-4092-2072	PROPN
iajs-3642	15	54	mailto:oday.h@sc.uobaghdad.edu.iq	mailto:oday.h@sc.uobaghdad.edu.iq	NOUN
iajs-3642	15	55	ihjpas	ihjpa	NOUN
iajs-3642	15	56	.	.	PUNCT
iajs-3642	16	1	2025	2025	NUM
iajs-3642	16	2	,	,	PUNCT
iajs-3642	16	3	38	38	NUM
iajs-3642	16	4	(	(	PUNCT
iajs-3642	16	5	1	1	NUM
iajs-3642	16	6	)	)	PUNCT
iajs-3642	16	7	314	314	NUM
iajs-3642	16	8	cell	cell	NOUN
iajs-3642	16	9	division	division	NOUN
iajs-3642	16	10	(	(	PUNCT
iajs-3642	16	11	1,2	1,2	NUM
iajs-3642	16	12	)	)	PUNCT
iajs-3642	16	13	.	.	PUNCT
iajs-3642	17	1	microtubules	microtubule	NOUN
iajs-3642	17	2	have	have	AUX
iajs-3642	17	3	been	be	AUX
iajs-3642	17	4	identified	identify	VERB
iajs-3642	17	5	as	as	ADP
iajs-3642	17	6	a	a	DET
iajs-3642	17	7	viable	viable	ADJ
iajs-3642	17	8	target	target	NOUN
iajs-3642	17	9	for	for	ADP
iajs-3642	17	10	chemotherapeutic	chemotherapeutic	ADJ
iajs-3642	17	11	drugs	drug	NOUN
iajs-3642	17	12	targeting	target	VERB
iajs-3642	17	13	breast	breast	NOUN
iajs-3642	17	14	cancer	cancer	NOUN
iajs-3642	17	15	cells	cell	NOUN
iajs-3642	17	16	during	during	ADP
iajs-3642	17	17	the	the	DET
iajs-3642	17	18	last	last	ADJ
iajs-3642	17	19	three	three	NUM
iajs-3642	17	20	decades	decade	NOUN
iajs-3642	17	21	due	due	ADP
iajs-3642	17	22	to	to	ADP
iajs-3642	17	23	their	their	PRON
iajs-3642	17	24	critical	critical	ADJ
iajs-3642	17	25	roles	role	NOUN
iajs-3642	17	26	in	in	ADP
iajs-3642	17	27	the	the	DET
iajs-3642	17	28	cell	cell	NOUN
iajs-3642	17	29	's	's	PART
iajs-3642	17	30	life	life	NOUN
iajs-3642	17	31	cycle	cycle	NOUN
iajs-3642	17	32	(	(	PUNCT
iajs-3642	17	33	3,4	3,4	NUM
iajs-3642	17	34	)	)	PUNCT
iajs-3642	17	35	.	.	PUNCT
iajs-3642	18	1	tubulin	tubulin	NOUN
iajs-3642	18	2	,	,	PUNCT
iajs-3642	18	3	a	a	DET
iajs-3642	18	4	(	(	PUNCT
iajs-3642	18	5	α	α	NOUN
iajs-3642	18	6	,	,	PUNCT
iajs-3642	18	7	β	β	NOUN
iajs-3642	18	8	-	-	NOUN
iajs-3642	18	9	heterodimer	heterodimer	NOUN
iajs-3642	18	10	)	)	PUNCT
iajs-3642	18	11	first	first	ADV
iajs-3642	18	12	discovered	discover	VERB
iajs-3642	18	13	as	as	ADP
iajs-3642	18	14	the	the	DET
iajs-3642	18	15	cellular	cellular	ADJ
iajs-3642	18	16	colchicinebinding	colchicinebinding	NOUN
iajs-3642	18	17	protein	protein	NOUN
iajs-3642	18	18	,	,	PUNCT
iajs-3642	18	19	targets	target	VERB
iajs-3642	18	20	many	many	ADJ
iajs-3642	18	21	small	small	ADJ
iajs-3642	18	22	-	-	PUNCT
iajs-3642	18	23	molecule	molecule	NOUN
iajs-3642	18	24	ligands	ligand	NOUN
iajs-3642	18	25	that	that	PRON
iajs-3642	18	26	interact	interact	VERB
iajs-3642	18	27	with	with	ADP
iajs-3642	18	28	microtubule	microtubule	NOUN
iajs-3642	18	29	dynamics	dynamic	NOUN
iajs-3642	18	30	and	and	CCONJ
iajs-3642	18	31	are	be	AUX
iajs-3642	18	32	therapeutically	therapeutically	ADV
iajs-3642	18	33	beneficial	beneficial	ADJ
iajs-3642	18	34	,	,	PUNCT
iajs-3642	18	35	notably	notably	ADV
iajs-3642	18	36	in	in	ADP
iajs-3642	18	37	cancer	cancer	NOUN
iajs-3642	18	38	therapy	therapy	NOUN
iajs-3642	18	39	(	(	PUNCT
iajs-3642	18	40	5	5	NUM
iajs-3642	18	41	)	)	PUNCT
iajs-3642	18	42	.	.	PUNCT
iajs-3642	19	1	colchicine	colchicine	PROPN
iajs-3642	19	2	binding	bind	VERB
iajs-3642	19	3	sites	site	NOUN
iajs-3642	19	4	have	have	AUX
iajs-3642	19	5	been	be	AUX
iajs-3642	19	6	modified	modify	VERB
iajs-3642	19	7	in	in	ADP
iajs-3642	19	8	terms	term	NOUN
iajs-3642	19	9	of	of	ADP
iajs-3642	19	10	chemical	chemical	ADJ
iajs-3642	19	11	structure	structure	NOUN
iajs-3642	19	12	and	and	CCONJ
iajs-3642	19	13	pharmacokinetic	pharmacokinetic	ADJ
iajs-3642	19	14	properties	property	NOUN
iajs-3642	19	15	and	and	CCONJ
iajs-3642	19	16	examined	examine	VERB
iajs-3642	19	17	to	to	PART
iajs-3642	19	18	develop	develop	VERB
iajs-3642	19	19	a	a	DET
iajs-3642	19	20	highly	highly	ADV
iajs-3642	19	21	effective	effective	ADJ
iajs-3642	19	22	,	,	PUNCT
iajs-3642	19	23	low	low	ADJ
iajs-3642	19	24	-	-	PUNCT
iajs-3642	19	25	toxicity	toxicity	NOUN
iajs-3642	19	26	medicine	medicine	NOUN
iajs-3642	19	27	for	for	ADP
iajs-3642	19	28	cancer	cancer	NOUN
iajs-3642	19	29	treatment	treatment	NOUN
iajs-3642	19	30	(	(	PUNCT
iajs-3642	19	31	6	6	NUM
iajs-3642	19	32	)	)	PUNCT
iajs-3642	19	33	.	.	PUNCT
iajs-3642	20	1	sulfonamide	sulfonamide	NOUN
iajs-3642	20	2	is	be	AUX
iajs-3642	20	3	one	one	NUM
iajs-3642	20	4	of	of	ADP
iajs-3642	20	5	the	the	DET
iajs-3642	20	6	essential	essential	ADJ
iajs-3642	20	7	building	building	NOUN
iajs-3642	20	8	blocks	block	NOUN
iajs-3642	20	9	in	in	ADP
iajs-3642	20	10	organic	organic	ADJ
iajs-3642	20	11	chemistry	chemistry	NOUN
iajs-3642	20	12	,	,	PUNCT
iajs-3642	20	13	with	with	ADP
iajs-3642	20	14	numerous	numerous	ADJ
iajs-3642	20	15	pharmaceutical	pharmaceutical	ADJ
iajs-3642	20	16	and	and	CCONJ
iajs-3642	20	17	pharmacological	pharmacological	ADJ
iajs-3642	20	18	agents	agent	NOUN
iajs-3642	20	19	exhibiting	exhibit	VERB
iajs-3642	20	20	antibacterial	antibacterial	ADJ
iajs-3642	20	21	,	,	PUNCT
iajs-3642	20	22	antibacterial	antibacterial	ADJ
iajs-3642	20	23	,	,	PUNCT
iajs-3642	20	24	antitiviral	antitiviral	ADJ
iajs-3642	20	25	,	,	PUNCT
iajs-3642	20	26	anti	anti	ADJ
iajs-3642	20	27	-	-	NOUN
iajs-3642	20	28	obesity	obesity	ADJ
iajs-3642	20	29	,	,	PUNCT
iajs-3642	20	30	anhydrase	anhydrase	NOUN
iajs-3642	20	31	,	,	PUNCT
iajs-3642	20	32	hiv	hiv	PROPN
iajs-3642	20	33	protease	protease	NOUN
iajs-3642	20	34	inhibitors	inhibitor	NOUN
iajs-3642	20	35	,	,	PUNCT
iajs-3642	20	36	diuretics	diuretic	NOUN
iajs-3642	20	37	,	,	PUNCT
iajs-3642	20	38	antithyroid	antithyroid	NOUN
iajs-3642	20	39	,	,	PUNCT
iajs-3642	20	40	antitumor	antitumor	PROPN
iajs-3642	20	41	,	,	PUNCT
iajs-3642	20	42	and	and	CCONJ
iajs-3642	20	43	anti	anti	ADJ
iajs-3642	20	44	-	-	ADJ
iajs-3642	20	45	neuropathic	neuropathic	ADJ
iajs-3642	20	46	pain	pain	NOUN
iajs-3642	20	47	activity	activity	NOUN
iajs-3642	20	48	(	(	PUNCT
iajs-3642	20	49	7,8	7,8	NUM
iajs-3642	20	50	)	)	PUNCT
iajs-3642	20	51	.	.	PUNCT
iajs-3642	21	1	new	new	ADJ
iajs-3642	21	2	oxadiazole	oxadiazole	NOUN
iajs-3642	21	3	-	-	PUNCT
iajs-3642	21	4	ringed	ringed	ADJ
iajs-3642	21	5	sulfonamides	sulfonamide	NOUN
iajs-3642	21	6	may	may	AUX
iajs-3642	21	7	inhibit	inhibit	VERB
iajs-3642	21	8	b	b	NOUN
iajs-3642	21	9	-	-	PUNCT
iajs-3642	21	10	glucuronidase	glucuronidase	NOUN
iajs-3642	21	11	(	(	PUNCT
iajs-3642	21	12	9	9	NUM
iajs-3642	21	13	)	)	PUNCT
iajs-3642	21	14	.	.	PUNCT
iajs-3642	22	1	previously	previously	ADV
iajs-3642	22	2	proven	prove	VERB
iajs-3642	22	3	to	to	PART
iajs-3642	22	4	have	have	VERB
iajs-3642	22	5	great	great	ADJ
iajs-3642	22	6	potential	potential	NOUN
iajs-3642	22	7	,	,	PUNCT
iajs-3642	22	8	sulphonamides	sulphonamide	NOUN
iajs-3642	22	9	containing	contain	VERB
iajs-3642	22	10	aliphatic	aliphatic	ADJ
iajs-3642	22	11	moieties	moiety	NOUN
iajs-3642	22	12	were	be	AUX
iajs-3642	22	13	synthesized	synthesize	VERB
iajs-3642	22	14	and	and	CCONJ
iajs-3642	22	15	tested	test	VERB
iajs-3642	22	16	for	for	ADP
iajs-3642	22	17	their	their	PRON
iajs-3642	22	18	α	α	NOUN
iajs-3642	22	19	-	-	NOUN
iajs-3642	22	20	glucosidase	glucosidase	ADJ
iajs-3642	22	21	,	,	PUNCT
iajs-3642	22	22	anti	anti	ADJ
iajs-3642	22	23	-	-	ADJ
iajs-3642	22	24	urease	urease	ADJ
iajs-3642	22	25	,	,	PUNCT
iajs-3642	22	26	antibacterial	antibacterial	ADJ
iajs-3642	22	27	,	,	PUNCT
iajs-3642	22	28	and	and	CCONJ
iajs-3642	22	29	antibacterial	antibacterial	ADJ
iajs-3642	22	30	properties	property	NOUN
iajs-3642	22	31	(	(	PUNCT
iajs-3642	22	32	10	10	NUM
iajs-3642	22	33	)	)	PUNCT
iajs-3642	22	34	.	.	PUNCT
iajs-3642	23	1	in	in	ADP
iajs-3642	23	2	organic	organic	ADJ
iajs-3642	23	3	solvent	solvent	NOUN
iajs-3642	23	4	-	-	PUNCT
iajs-3642	23	5	free	free	ADJ
iajs-3642	23	6	water	water	NOUN
iajs-3642	23	7	-	-	PUNCT
iajs-3642	23	8	based	base	VERB
iajs-3642	23	9	sulfonyl	sulfonyl	NOUN
iajs-3642	23	10	hydrazide	hydrazide	ADJ
iajs-3642	23	11	synthesis	synthesis	NOUN
iajs-3642	23	12	,	,	PUNCT
iajs-3642	23	13	an	an	DET
iajs-3642	23	14	equimolar	equimolar	NOUN
iajs-3642	23	15	amount	amount	NOUN
iajs-3642	23	16	of	of	ADP
iajs-3642	23	17	sulfonyl	sulfonyl	NOUN
iajs-3642	23	18	chlorides	chloride	NOUN
iajs-3642	23	19	and	and	CCONJ
iajs-3642	23	20	hydrochlorides	hydrochloride	NOUN
iajs-3642	23	21	react	react	VERB
iajs-3642	23	22	at	at	ADP
iajs-3642	23	23	60˚c	60˚c	NUM
iajs-3642	23	24	for	for	ADP
iajs-3642	23	25	1	1	NUM
iajs-3642	23	26	hour	hour	NOUN
iajs-3642	23	27	in	in	ADP
iajs-3642	23	28	water	water	NOUN
iajs-3642	23	29	with	with	ADP
iajs-3642	23	30	et3n	et3n	PROPN
iajs-3642	23	31	to	to	PART
iajs-3642	23	32	form	form	VERB
iajs-3642	23	33	a	a	DET
iajs-3642	23	34	series	series	NOUN
iajs-3642	23	35	of	of	ADP
iajs-3642	23	36	substituted	substitute	VERB
iajs-3642	23	37	hydrazides	hydrazide	NOUN
iajs-3642	23	38	(	(	PUNCT
iajs-3642	23	39	11	11	NUM
iajs-3642	23	40	)	)	PUNCT
iajs-3642	23	41	.	.	PUNCT
iajs-3642	24	1	many	many	ADJ
iajs-3642	24	2	researchers	researcher	NOUN
iajs-3642	24	3	have	have	AUX
iajs-3642	24	4	found	find	VERB
iajs-3642	24	5	effective	effective	ADJ
iajs-3642	24	6	oral	oral	ADJ
iajs-3642	24	7	influenza	influenza	NOUN
iajs-3642	24	8	virus	virus	NOUN
iajs-3642	24	9	inhibitors	inhibitor	NOUN
iajs-3642	24	10	based	base	VERB
iajs-3642	24	11	on	on	ADP
iajs-3642	24	12	an	an	DET
iajs-3642	24	13	aryl	aryl	NOUN
iajs-3642	24	14	benzoyl	benzoyl	NOUN
iajs-3642	24	15	hydrazide	hydrazide	ADJ
iajs-3642	24	16	scaffold	scaffold	NOUN
iajs-3642	24	17	and	and	CCONJ
iajs-3642	24	18	antiviral	antiviral	ADJ
iajs-3642	24	19	(	(	PUNCT
iajs-3642	24	20	12	12	NUM
iajs-3642	24	21	)	)	PUNCT
iajs-3642	24	22	.	.	PUNCT
iajs-3642	25	1	drug	drug	NOUN
iajs-3642	25	2	development	development	NOUN
iajs-3642	25	3	,	,	PUNCT
iajs-3642	25	4	materials	material	NOUN
iajs-3642	25	5	,	,	PUNCT
iajs-3642	25	6	and	and	CCONJ
iajs-3642	25	7	agrochemicals	agrochemical	NOUN
iajs-3642	25	8	use	use	VERB
iajs-3642	25	9	benzylic	benzylic	ADJ
iajs-3642	25	10	derivatives	derivative	NOUN
iajs-3642	25	11	.	.	PUNCT
iajs-3642	26	1	in	in	ADP
iajs-3642	26	2	environmentally	environmentally	ADV
iajs-3642	26	3	friendly	friendly	ADJ
iajs-3642	26	4	solvents	solvent	NOUN
iajs-3642	26	5	,	,	PUNCT
iajs-3642	26	6	many	many	ADJ
iajs-3642	26	7	methods	method	NOUN
iajs-3642	26	8	produce	produce	VERB
iajs-3642	26	9	benzylic	benzylic	ADJ
iajs-3642	26	10	derivatives	derivative	NOUN
iajs-3642	26	11	on	on	ADP
iajs-3642	26	12	beneficial	beneficial	ADJ
iajs-3642	26	13	pharmaceutical	pharmaceutical	ADJ
iajs-3642	26	14	molecules	molecule	NOUN
iajs-3642	26	15	(	(	PUNCT
iajs-3642	26	16	13	13	NUM
iajs-3642	26	17	)	)	PUNCT
iajs-3642	26	18	.	.	PUNCT
iajs-3642	27	1	some	some	DET
iajs-3642	27	2	benzyl	benzyl	NOUN
iajs-3642	27	3	derivatives	derivative	NOUN
iajs-3642	27	4	are	be	AUX
iajs-3642	27	5	used	use	VERB
iajs-3642	27	6	as	as	ADP
iajs-3642	27	7	inhibitors	inhibitor	NOUN
iajs-3642	27	8	of	of	ADP
iajs-3642	27	9	the	the	DET
iajs-3642	27	10	corrosion	corrosion	NOUN
iajs-3642	27	11	of	of	ADP
iajs-3642	27	12	carbon	carbon	NOUN
iajs-3642	27	13	steel	steel	NOUN
iajs-3642	27	14	in	in	ADP
iajs-3642	27	15	hcl	hcl	PROPN
iajs-3642	27	16	and	and	CCONJ
iajs-3642	27	17	h2so4	h2so4	PROPN
iajs-3642	27	18	media	media	PROPN
iajs-3642	27	19	(	(	PUNCT
iajs-3642	27	20	14,15	14,15	NUM
iajs-3642	27	21	)	)	PUNCT
iajs-3642	27	22	.	.	PUNCT
iajs-3642	28	1	some	some	DET
iajs-3642	28	2	compounds	compound	NOUN
iajs-3642	28	3	from	from	ADP
iajs-3642	28	4	aryl	aryl	NOUN
iajs-3642	28	5	sulfonylhydrazides	sulfonylhydrazide	NOUN
iajs-3642	28	6	and	and	CCONJ
iajs-3642	28	7	benzylic	benzylic	ADJ
iajs-3642	28	8	ammonium	ammonium	NOUN
iajs-3642	28	9	salts	salt	NOUN
iajs-3642	28	10	have	have	VERB
iajs-3642	28	11	good	good	ADJ
iajs-3642	28	12	efficiency	efficiency	NOUN
iajs-3642	28	13	and	and	CCONJ
iajs-3642	28	14	simple	simple	ADJ
iajs-3642	28	15	handling	handling	NOUN
iajs-3642	28	16	(	(	PUNCT
iajs-3642	28	17	16	16	NUM
iajs-3642	28	18	)	)	PUNCT
iajs-3642	28	19	.	.	PUNCT
iajs-3642	29	1	aryl	aryl	NOUN
iajs-3642	29	2	benzoyl	benzoyl	PROPN
iajs-3642	29	3	hydrazide	hydrazide	ADJ
iajs-3642	29	4	derivatives	derivative	NOUN
iajs-3642	29	5	have	have	AUX
iajs-3642	29	6	been	be	AUX
iajs-3642	29	7	studied	study	VERB
iajs-3642	29	8	in	in	ADP
iajs-3642	29	9	silico	silico	NOUN
iajs-3642	29	10	as	as	ADP
iajs-3642	29	11	influenza	influenza	NOUN
iajs-3642	29	12	virus	virus	NOUN
iajs-3642	29	13	antivirals	antiviral	NOUN
iajs-3642	29	14	,	,	PUNCT
iajs-3642	29	15	and	and	CCONJ
iajs-3642	29	16	these	these	PRON
iajs-3642	29	17	showed	show	VERB
iajs-3642	29	18	significant	significant	ADJ
iajs-3642	29	19	antiviral	antiviral	ADJ
iajs-3642	29	20	factors	factor	NOUN
iajs-3642	29	21	and	and	CCONJ
iajs-3642	29	22	antimicrobial	antimicrobial	ADJ
iajs-3642	29	23	agents	agent	NOUN
iajs-3642	29	24	(	(	PUNCT
iajs-3642	29	25	17,18	17,18	NUM
iajs-3642	29	26	)	)	PUNCT
iajs-3642	29	27	.	.	PUNCT
iajs-3642	30	1	lipinski	lipinski	PROPN
iajs-3642	30	2	's	's	PART
iajs-3642	30	3	rule	rule	NOUN
iajs-3642	30	4	of	of	ADP
iajs-3642	30	5	five	five	NUM
iajs-3642	30	6	(	(	PUNCT
iajs-3642	30	7	ro5	ro5	NOUN
iajs-3642	30	8	)	)	PUNCT
iajs-3642	30	9	is	be	AUX
iajs-3642	30	10	used	use	VERB
iajs-3642	30	11	in	in	ADP
iajs-3642	30	12	drug	drug	NOUN
iajs-3642	30	13	development	development	NOUN
iajs-3642	30	14	to	to	PART
iajs-3642	30	15	predict	predict	VERB
iajs-3642	30	16	if	if	SCONJ
iajs-3642	30	17	a	a	DET
iajs-3642	30	18	bioactive	bioactive	ADJ
iajs-3642	30	19	molecule	molecule	NOUN
iajs-3642	30	20	is	be	AUX
iajs-3642	30	21	orally	orally	ADV
iajs-3642	30	22	bioavailable	bioavailable	ADJ
iajs-3642	30	23	based	base	VERB
iajs-3642	30	24	on	on	ADP
iajs-3642	30	25	drug	drug	NOUN
iajs-3642	30	26	physicochemical	physicochemical	ADJ
iajs-3642	30	27	features	feature	NOUN
iajs-3642	30	28	like	like	ADP
iajs-3642	30	29	absorption	absorption	NOUN
iajs-3642	30	30	,	,	PUNCT
iajs-3642	30	31	distribution	distribution	NOUN
iajs-3642	30	32	,	,	PUNCT
iajs-3642	30	33	metabolism	metabolism	NOUN
iajs-3642	30	34	,	,	PUNCT
iajs-3642	30	35	and	and	CCONJ
iajs-3642	30	36	excretion	excretion	NOUN
iajs-3642	30	37	(	(	PUNCT
iajs-3642	30	38	adme	adme	NOUN
iajs-3642	30	39	)	)	PUNCT
iajs-3642	30	40	(	(	PUNCT
iajs-3642	30	41	19	19	NUM
iajs-3642	30	42	)	)	PUNCT
iajs-3642	30	43	.	.	PUNCT
iajs-3642	31	1	early	early	ADJ
iajs-3642	31	2	prediction	prediction	NOUN
iajs-3642	31	3	of	of	ADP
iajs-3642	31	4	adme	adme	NOUN
iajs-3642	31	5	parameters	parameter	NOUN
iajs-3642	31	6	has	have	AUX
iajs-3642	31	7	been	be	AUX
iajs-3642	31	8	shown	show	VERB
iajs-3642	31	9	to	to	PART
iajs-3642	31	10	significantly	significantly	ADV
iajs-3642	31	11	reduce	reduce	VERB
iajs-3642	31	12	the	the	DET
iajs-3642	31	13	rate	rate	NOUN
iajs-3642	31	14	of	of	ADP
iajs-3642	31	15	pharmacokinetic	pharmacokinetic	ADJ
iajs-3642	31	16	failure	failure	NOUN
iajs-3642	31	17	in	in	ADP
iajs-3642	31	18	clinical	clinical	ADJ
iajs-3642	31	19	phases	phase	NOUN
iajs-3642	31	20	during	during	ADP
iajs-3642	31	21	the	the	DET
iajs-3642	31	22	design	design	NOUN
iajs-3642	31	23	phase	phase	NOUN
iajs-3642	31	24	and	and	CCONJ
iajs-3642	31	25	determine	determine	VERB
iajs-3642	31	26	if	if	SCONJ
iajs-3642	31	27	a	a	DET
iajs-3642	31	28	compound	compound	NOUN
iajs-3642	31	29	has	have	VERB
iajs-3642	31	30	a	a	DET
iajs-3642	31	31	chance	chance	NOUN
iajs-3642	31	32	to	to	PART
iajs-3642	31	33	be	be	AUX
iajs-3642	31	34	a	a	DET
iajs-3642	31	35	promising	promising	ADJ
iajs-3642	31	36	drug	drug	NOUN
iajs-3642	31	37	(	(	PUNCT
iajs-3642	31	38	20	20	NUM
iajs-3642	31	39	)	)	PUNCT
iajs-3642	31	40	.	.	PUNCT
iajs-3642	32	1	gold	gold	NOUN
iajs-3642	32	2	refers	refer	VERB
iajs-3642	32	3	to	to	ADP
iajs-3642	32	4	the	the	DET
iajs-3642	32	5	"	"	PUNCT
iajs-3642	32	6	genetic	genetic	ADJ
iajs-3642	32	7	method	method	NOUN
iajs-3642	32	8	for	for	ADP
iajs-3642	32	9	docking	dock	VERB
iajs-3642	32	10	flexible	flexible	ADJ
iajs-3642	32	11	ligands	ligand	NOUN
iajs-3642	32	12	into	into	ADP
iajs-3642	32	13	a	a	DET
iajs-3642	32	14	protein	protein	NOUN
iajs-3642	32	15	binding	bind	VERB
iajs-3642	32	16	site	site	NOUN
iajs-3642	32	17	.	.	PUNCT
iajs-3642	32	18	"	"	PUNCT
iajs-3642	33	1	it	it	PRON
iajs-3642	33	2	shows	show	VERB
iajs-3642	33	3	the	the	DET
iajs-3642	33	4	optimum	optimum	ADJ
iajs-3642	33	5	orientation	orientation	NOUN
iajs-3642	33	6	for	for	ADP
iajs-3642	33	7	a	a	DET
iajs-3642	33	8	ligand	ligand	NOUN
iajs-3642	33	9	that	that	PRON
iajs-3642	33	10	links	link	VERB
iajs-3642	33	11	to	to	ADP
iajs-3642	33	12	a	a	DET
iajs-3642	33	13	protein	protein	NOUN
iajs-3642	33	14	's	's	PART
iajs-3642	33	15	active	active	ADJ
iajs-3642	33	16	site	site	NOUN
iajs-3642	33	17	(	(	PUNCT
iajs-3642	33	18	21,22	21,22	NOUN
iajs-3642	33	19	)	)	PUNCT
iajs-3642	33	20	.	.	PUNCT
iajs-3642	34	1	the	the	DET
iajs-3642	34	2	"	"	PUNCT
iajs-3642	34	3	boiled	boil	VERB
iajs-3642	34	4	-	-	PUNCT
iajs-3642	34	5	egg	egg	NOUN
iajs-3642	34	6	"	"	PUNCT
iajs-3642	34	7	predicts	predict	VERB
iajs-3642	34	8	small	small	ADJ
iajs-3642	34	9	molecule	molecule	NOUN
iajs-3642	34	10	intestinal	intestinal	ADJ
iajs-3642	34	11	absorption	absorption	NOUN
iajs-3642	34	12	and	and	CCONJ
iajs-3642	34	13	brain	brain	NOUN
iajs-3642	34	14	penetration	penetration	NOUN
iajs-3642	34	15	(	(	PUNCT
iajs-3642	34	16	23	23	NUM
iajs-3642	34	17	)	)	PUNCT
iajs-3642	34	18	.	.	PUNCT
iajs-3642	35	1	it	it	PRON
iajs-3642	35	2	estimates	estimate	VERB
iajs-3642	35	3	small	small	ADJ
iajs-3642	35	4	molecules	molecule	NOUN
iajs-3642	35	5	'	'	PART
iajs-3642	35	6	lipophilicity	lipophilicity	NOUN
iajs-3642	35	7	,	,	PUNCT
iajs-3642	35	8	polarity	polarity	NOUN
iajs-3642	35	9	,	,	PUNCT
iajs-3642	35	10	human	human	ADJ
iajs-3642	35	11	intestinal	intestinal	ADJ
iajs-3642	35	12	absorption	absorption	NOUN
iajs-3642	35	13	(	(	PUNCT
iajs-3642	35	14	hia	hia	PROPN
iajs-3642	35	15	)	)	PUNCT
iajs-3642	35	16	,	,	PUNCT
iajs-3642	35	17	and	and	CCONJ
iajs-3642	35	18	brain	brain	NOUN
iajs-3642	35	19	access	access	NOUN
iajs-3642	35	20	(	(	PUNCT
iajs-3642	35	21	bbb	bbb	PROPN
iajs-3642	35	22	)	)	PUNCT
iajs-3642	35	23	(	(	PUNCT
iajs-3642	35	24	20	20	NUM
iajs-3642	35	25	)	)	PUNCT
iajs-3642	35	26	and	and	CCONJ
iajs-3642	35	27	tests	test	VERB
iajs-3642	35	28	therapeutic	therapeutic	ADJ
iajs-3642	35	29	candidate	candidate	NOUN
iajs-3642	35	30	assessment	assessment	NOUN
iajs-3642	35	31	(	(	PUNCT
iajs-3642	35	32	20	20	NUM
iajs-3642	35	33	)	)	PUNCT
iajs-3642	35	34	.	.	PUNCT
iajs-3642	36	1	drug	drug	NOUN
iajs-3642	36	2	-	-	PUNCT
iajs-3642	36	3	likeness	likeness	NOUN
iajs-3642	36	4	,	,	PUNCT
iajs-3642	36	5	medicinal	medicinal	ADJ
iajs-3642	36	6	chemistry	chemistry	NOUN
iajs-3642	36	7	,	,	PUNCT
iajs-3642	36	8	adme	adme	VERB
iajs-3642	36	9	pharmacokinetics	pharmacokinetic	NOUN
iajs-3642	36	10	,	,	PUNCT
iajs-3642	36	11	and	and	CCONJ
iajs-3642	36	12	physicochemical	physicochemical	ADJ
iajs-3642	36	13	features	feature	NOUN
iajs-3642	36	14	are	be	AUX
iajs-3642	36	15	connected	connect	VERB
iajs-3642	36	16	to	to	ADP
iajs-3642	36	17	this	this	DET
iajs-3642	36	18	model	model	NOUN
iajs-3642	36	19	(	(	PUNCT
iajs-3642	36	20	22	22	NUM
iajs-3642	36	21	)	)	PUNCT
iajs-3642	36	22	.	.	PUNCT
iajs-3642	37	1	this	this	DET
iajs-3642	37	2	study	study	NOUN
iajs-3642	37	3	aims	aim	VERB
iajs-3642	37	4	to	to	PART
iajs-3642	37	5	prepare	prepare	VERB
iajs-3642	37	6	a	a	DET
iajs-3642	37	7	new	new	ADJ
iajs-3642	37	8	series	series	NOUN
iajs-3642	37	9	of	of	ADP
iajs-3642	37	10	derivatives	derivative	NOUN
iajs-3642	37	11	containing	contain	VERB
iajs-3642	37	12	succinohydrazide	succinohydrazide	ADV
iajs-3642	37	13	as	as	ADP
iajs-3642	37	14	a	a	DET
iajs-3642	37	15	precursor	precursor	NOUN
iajs-3642	37	16	.	.	PUNCT
iajs-3642	38	1	ihjpas	ihjpas	PROPN
iajs-3642	38	2	.	.	PUNCT
iajs-3642	39	1	2025	2025	NUM
iajs-3642	39	2	,	,	PUNCT
iajs-3642	39	3	38	38	NUM
iajs-3642	39	4	(	(	PUNCT
iajs-3642	39	5	1	1	NUM
iajs-3642	39	6	)	)	PUNCT
iajs-3642	39	7	315	315	NUM
iajs-3642	39	8	2	2	NUM
iajs-3642	39	9	.	.	PUNCT
iajs-3642	39	10	materials	material	NOUN
iajs-3642	39	11	and	and	CCONJ
iajs-3642	39	12	methods	method	NOUN
iajs-3642	39	13	2.1	2.1	NUM
iajs-3642	39	14	.	.	PUNCT
iajs-3642	40	1	instruments	instrument	NOUN
iajs-3642	40	2	all	all	DET
iajs-3642	40	3	chemical	chemical	NOUN
iajs-3642	40	4	compounds	compound	NOUN
iajs-3642	40	5	were	be	AUX
iajs-3642	40	6	used	use	VERB
iajs-3642	40	7	without	without	ADP
iajs-3642	40	8	further	further	ADJ
iajs-3642	40	9	purification	purification	NOUN
iajs-3642	40	10	and	and	CCONJ
iajs-3642	40	11	obtained	obtain	VERB
iajs-3642	40	12	from	from	ADP
iajs-3642	40	13	bdh	bdh	NOUN
iajs-3642	40	14	,	,	PUNCT
iajs-3642	40	15	fluka	fluka	NOUN
iajs-3642	40	16	,	,	PUNCT
iajs-3642	40	17	aldrich	aldrich	NOUN
iajs-3642	40	18	,	,	PUNCT
iajs-3642	40	19	and	and	CCONJ
iajs-3642	40	20	merck	merck	PROPN
iajs-3642	40	21	companies	company	NOUN
iajs-3642	40	22	.	.	PUNCT
iajs-3642	41	1	thin	thin	ADJ
iajs-3642	41	2	-	-	PUNCT
iajs-3642	41	3	layer	layer	NOUN
iajs-3642	41	4	chromatography	chromatography	NOUN
iajs-3642	41	5	(	(	PUNCT
iajs-3642	41	6	tlc	tlc	NOUN
iajs-3642	41	7	)	)	PUNCT
iajs-3642	41	8	was	be	AUX
iajs-3642	41	9	used	use	VERB
iajs-3642	41	10	on	on	ADP
iajs-3642	41	11	pre	pre	ADJ
iajs-3642	41	12	-	-	ADJ
iajs-3642	41	13	coated	coated	ADJ
iajs-3642	41	14	merck	merck	NOUN
iajs-3642	41	15	(	(	PUNCT
iajs-3642	41	16	macherey	macherey	PROPN
iajs-3642	41	17	-	-	PUNCT
iajs-3642	41	18	nagel	nagel	PROPN
iajs-3642	41	19	,	,	PUNCT
iajs-3642	41	20	germany	germany	PROPN
iajs-3642	41	21	)	)	PUNCT
iajs-3642	41	22	silica	silica	NOUN
iajs-3642	41	23	gel	gel	NOUN
iajs-3642	41	24	60	60	NUM
iajs-3642	41	25	-	-	PUNCT
iajs-3642	41	26	f	f	NOUN
iajs-3642	41	27	plates	plate	NOUN
iajs-3642	41	28	with	with	ADP
iajs-3642	41	29	a	a	DET
iajs-3642	41	30	layer	layer	NOUN
iajs-3642	41	31	thickness	thickness	NOUN
iajs-3642	41	32	of	of	ADP
iajs-3642	41	33	0.25	0.25	NUM
iajs-3642	41	34	mm	mm	NOUN
iajs-3642	41	35	(	(	PUNCT
iajs-3642	41	36	merck	merck	PROPN
iajs-3642	41	37	)	)	PUNCT
iajs-3642	41	38	.	.	PUNCT
iajs-3642	42	1	a	a	DET
iajs-3642	42	2	mixture	mixture	NOUN
iajs-3642	42	3	of	of	ADP
iajs-3642	42	4	hexane	hexane	NOUN
iajs-3642	42	5	3:2	3:2	NUM
iajs-3642	42	6	ethanol	ethanol	NOUN
iajs-3642	42	7	was	be	AUX
iajs-3642	42	8	used	use	VERB
iajs-3642	42	9	to	to	PART
iajs-3642	42	10	develop	develop	VERB
iajs-3642	42	11	the	the	DET
iajs-3642	42	12	solvent	solvent	NOUN
iajs-3642	42	13	system	system	NOUN
iajs-3642	42	14	tlc	tlc	NOUN
iajs-3642	42	15	eluent	eluent	NOUN
iajs-3642	42	16	,	,	PUNCT
iajs-3642	42	17	and	and	CCONJ
iajs-3642	42	18	an	an	DET
iajs-3642	42	19	ultraviolet	ultraviolet	NOUN
iajs-3642	42	20	lamp	lamp	NOUN
iajs-3642	42	21	detected	detect	VERB
iajs-3642	42	22	the	the	DET
iajs-3642	42	23	spots	spot	NOUN
iajs-3642	42	24	.	.	PUNCT
iajs-3642	43	1	a	a	DET
iajs-3642	43	2	molecular	molecular	ADJ
iajs-3642	43	3	docking	docking	NOUN
iajs-3642	43	4	study	study	NOUN
iajs-3642	43	5	was	be	AUX
iajs-3642	43	6	done	do	VERB
iajs-3642	43	7	at	at	ADP
iajs-3642	43	8	the	the	DET
iajs-3642	43	9	college	college	NOUN
iajs-3642	43	10	of	of	ADP
iajs-3642	43	11	pharmacy	pharmacy	NOUN
iajs-3642	43	12	/al	/al	NOUN
iajs-3642	43	13	-	-	PUNCT
iajs-3642	43	14	nahrain	nahrain	PROPN
iajs-3642	43	15	university	university	NOUN
iajs-3642	43	16	.	.	PUNCT
iajs-3642	44	1	the	the	DET
iajs-3642	44	2	melting	melting	NOUN
iajs-3642	44	3	points	point	NOUN
iajs-3642	44	4	of	of	ADP
iajs-3642	44	5	the	the	DET
iajs-3642	44	6	synthesized	synthesize	VERB
iajs-3642	44	7	compounds	compound	NOUN
iajs-3642	44	8	were	be	AUX
iajs-3642	44	9	recorded	record	VERB
iajs-3642	44	10	using	use	VERB
iajs-3642	44	11	an	an	DET
iajs-3642	44	12	electro	electro	ADJ
iajs-3642	44	13	-	-	PUNCT
iajs-3642	44	14	thermal	thermal	ADJ
iajs-3642	44	15	melting	melting	NOUN
iajs-3642	44	16	point	point	NOUN
iajs-3642	44	17	apparatus	apparatus	NOUN
iajs-3642	44	18	.	.	PUNCT
iajs-3642	45	1	the	the	DET
iajs-3642	45	2	ir	ir	PROPN
iajs-3642	45	3	analysis	analysis	NOUN
iajs-3642	45	4	was	be	AUX
iajs-3642	45	5	conducted	conduct	VERB
iajs-3642	45	6	using	use	VERB
iajs-3642	45	7	an	an	DET
iajs-3642	45	8	ft	ft	NOUN
iajs-3642	45	9	-	-	PUNCT
iajs-3642	45	10	ir	ir	PROPN
iajs-3642	45	11	alpha	alpha	PROPN
iajs-3642	45	12	ii	ii	PROPN
iajs-3642	45	13	spectrometer	spectrometer	NOUN
iajs-3642	45	14	(	(	PUNCT
iajs-3642	45	15	bruker	bruker	PROPN
iajs-3642	45	16	)	)	PUNCT
iajs-3642	45	17	at	at	ADP
iajs-3642	45	18	mustansiriyah	mustansiriyah	PROPN
iajs-3642	45	19	university	university	PROPN
iajs-3642	45	20	/	/	SYM
iajs-3642	45	21	college	college	NOUN
iajs-3642	45	22	of	of	ADP
iajs-3642	45	23	science	science	NOUN
iajs-3642	45	24	.	.	PUNCT
iajs-3642	46	1	nmr	nmr	NOUN
iajs-3642	46	2	analyses	analysis	NOUN
iajs-3642	46	3	were	be	AUX
iajs-3642	46	4	performed	perform	VERB
iajs-3642	46	5	via	via	ADP
iajs-3642	46	6	1h	1h	NUM
iajs-3642	46	7	nmr	nmr	NOUN
iajs-3642	46	8	at	at	ADP
iajs-3642	46	9	500	500	NUM
iajs-3642	46	10	mhz	mhz	ADJ
iajs-3642	46	11	and	and	CCONJ
iajs-3642	46	12	13c	13c	NOUN
iajs-3642	46	13	nmr	nmr	NOUN
iajs-3642	46	14	at	at	ADP
iajs-3642	46	15	125	125	NUM
iajs-3642	46	16	mhz	mhz	NOUN
iajs-3642	46	17	(	(	PUNCT
iajs-3642	46	18	varianinova	varianinova	PROPN
iajs-3642	46	19	)	)	PUNCT
iajs-3642	46	20	.	.	PUNCT
iajs-3642	47	1	the	the	DET
iajs-3642	47	2	solvent	solvent	NOUN
iajs-3642	47	3	used	use	VERB
iajs-3642	47	4	was	be	AUX
iajs-3642	47	5	(	(	PUNCT
iajs-3642	47	6	dmso	dmso	ADJ
iajs-3642	47	7	-	-	NOUN
iajs-3642	47	8	d6	d6	NOUN
iajs-3642	47	9	)	)	PUNCT
iajs-3642	47	10	,	,	PUNCT
iajs-3642	47	11	and	and	CCONJ
iajs-3642	47	12	the	the	DET
iajs-3642	47	13	internal	internal	ADJ
iajs-3642	47	14	reference	reference	NOUN
iajs-3642	47	15	was	be	AUX
iajs-3642	47	16	tms	tms	PROPN
iajs-3642	47	17	.	.	PUNCT
iajs-3642	48	1	2.2	2.2	NUM
iajs-3642	48	2	.	.	PUNCT
iajs-3642	48	3	synthesis	synthesis	NOUN
iajs-3642	48	4	of	of	ADP
iajs-3642	48	5	succinohydrazide	succinohydrazide	ADJ
iajs-3642	48	6	(	(	PUNCT
iajs-3642	48	7	1	1	X
iajs-3642	48	8	)	)	PUNCT
iajs-3642	48	9	succinohydrazide	succinohydrazide	NOUN
iajs-3642	48	10	was	be	AUX
iajs-3642	48	11	produced	produce	VERB
iajs-3642	48	12	using	use	VERB
iajs-3642	48	13	previously	previously	ADV
iajs-3642	48	14	reported	report	VERB
iajs-3642	48	15	methods	method	NOUN
iajs-3642	48	16	and	and	CCONJ
iajs-3642	48	17	described	describe	VERB
iajs-3642	48	18	[	[	PUNCT
iajs-3642	48	19	24	24	NUM
iajs-3642	48	20	]	]	X
iajs-3642	48	21	physical	physical	ADJ
iajs-3642	48	22	properties	property	NOUN
iajs-3642	48	23	show	show	VERB
iajs-3642	48	24	in	in	ADP
iajs-3642	48	25	table	table	NOUN
iajs-3642	48	26	1	1	NUM
iajs-3642	48	27	.	.	PUNCT
iajs-3642	48	28	ft	ft	PROPN
iajs-3642	48	29	-	-	PUNCT
iajs-3642	48	30	ir	ir	PROPN
iajs-3642	48	31	(	(	PUNCT
iajs-3642	48	32	υ	υ	PROPN
iajs-3642	48	33	,	,	PUNCT
iajs-3642	48	34	cm-1	cm-1	NOUN
iajs-3642	48	35	):	):	PUNCT
iajs-3642	48	36	3306,3286	3306,3286	PROPN
iajs-3642	48	37	(	(	PUNCT
iajs-3642	48	38	nh2	nh2	PROPN
iajs-3642	48	39	)	)	PUNCT
iajs-3642	48	40	,	,	PUNCT
iajs-3642	48	41	3180	3180	NUM
iajs-3642	48	42	(	(	PUNCT
iajs-3642	48	43	n	n	CCONJ
iajs-3642	48	44	-	-	PUNCT
iajs-3642	48	45	h	h	NOUN
iajs-3642	48	46	)	)	PUNCT
iajs-3642	48	47	,	,	PUNCT
iajs-3642	48	48	2981,2875	2981,2875	PROPN
iajs-3642	48	49	(	(	PUNCT
iajs-3642	48	50	chaliph	chaliph	NOUN
iajs-3642	48	51	.	.	PUNCT
iajs-3642	48	52	)	)	PUNCT
iajs-3642	48	53	,	,	PUNCT
iajs-3642	48	54	1622	1622	NUM
iajs-3642	48	55	(	(	PUNCT
iajs-3642	48	56	c	c	NOUN
iajs-3642	48	57	=	=	NOUN
iajs-3642	48	58	oamide	oamide	ADJ
iajs-3642	48	59	)	)	PUNCT
iajs-3642	48	60	;	;	PUNCT
iajs-3642	48	61	1h	1h	NUM
iajs-3642	48	62	nmr	nmr	NOUN
iajs-3642	48	63	(	(	PUNCT
iajs-3642	48	64	h	h	PROPN
iajs-3642	48	65	,	,	PUNCT
iajs-3642	48	66	ppm	ppm	NOUN
iajs-3642	48	67	):	):	PUNCT
iajs-3642	48	68	8.98	8.98	NUM
iajs-3642	48	69	(	(	PUNCT
iajs-3642	48	70	2h	2h	NUM
iajs-3642	48	71	,	,	PUNCT
iajs-3642	48	72	s	s	X
iajs-3642	48	73	,	,	PUNCT
iajs-3642	48	74	nh	nh	PROPN
iajs-3642	48	75	-	-	PUNCT
iajs-3642	48	76	c	c	NOUN
iajs-3642	48	77	=	=	NOUN
iajs-3642	48	78	o	o	NOUN
iajs-3642	48	79	)	)	PUNCT
iajs-3642	48	80	,	,	PUNCT
iajs-3642	48	81	4.14	4.14	NUM
iajs-3642	48	82	(	(	PUNCT
iajs-3642	48	83	4h	4h	NUM
iajs-3642	48	84	,	,	PUNCT
iajs-3642	48	85	s	s	X
iajs-3642	48	86	,	,	PUNCT
iajs-3642	48	87	nh2	nh2	PROPN
iajs-3642	48	88	)	)	PUNCT
iajs-3642	48	89	,	,	PUNCT
iajs-3642	48	90	2.612.57	2.612.57	NUM
iajs-3642	48	91	(	(	PUNCT
iajs-3642	48	92	4h	4h	NUM
iajs-3642	48	93	,	,	PUNCT
iajs-3642	48	94	t	t	PROPN
iajs-3642	48	95	,	,	PUNCT
iajs-3642	48	96	ch2	ch2	PROPN
iajs-3642	48	97	)	)	PUNCT
iajs-3642	48	98	;	;	PUNCT
iajs-3642	48	99	13c	13c	X
iajs-3642	48	100	nmr	nmr	NOUN
iajs-3642	48	101	(	(	PUNCT
iajs-3642	48	102	c	c	NOUN
iajs-3642	48	103	,	,	PUNCT
iajs-3642	48	104	ppm	ppm	NOUN
iajs-3642	48	105	):	):	PUNCT
iajs-3642	48	106	171.22	171.22	NUM
iajs-3642	48	107	(	(	PUNCT
iajs-3642	48	108	c	c	NOUN
iajs-3642	48	109	=	=	NOUN
iajs-3642	48	110	o	o	NOUN
iajs-3642	48	111	)	)	PUNCT
iajs-3642	48	112	,	,	PUNCT
iajs-3642	48	113	29.40	29.40	NUM
iajs-3642	48	114	(	(	PUNCT
iajs-3642	48	115	ch2	ch2	PROPN
iajs-3642	48	116	-	-	PUNCT
iajs-3642	48	117	ch2	ch2	NOUN
iajs-3642	48	118	)	)	PUNCT
iajs-3642	48	119	.	.	PUNCT
iajs-3642	49	1	2.3	2.3	NUM
iajs-3642	49	2	.	.	PUNCT
iajs-3642	49	3	synthesis	synthesis	NOUN
iajs-3642	49	4	of	of	ADP
iajs-3642	49	5	n'1,n'4	n'1,n'4	NUM
iajs-3642	49	6	-	-	PUNCT
iajs-3642	49	7	dibenzoylsuccinohydrazide	dibenzoylsuccinohydrazide	NOUN
iajs-3642	49	8	(	(	PUNCT
iajs-3642	49	9	2a	2a	NUM
iajs-3642	49	10	)	)	PUNCT
iajs-3642	49	11	and	and	CCONJ
iajs-3642	49	12	n'1,n'4	n'1,n'4	NUM
iajs-3642	49	13	-	-	PUNCT
iajs-3642	49	14	bis(4	bis(4	NOUN
iajs-3642	49	15	-	-	PUNCT
iajs-3642	49	16	methoxy	methoxy	ADJ
iajs-3642	49	17	benzoyl	benzoyl	NOUN
iajs-3642	49	18	)	)	PUNCT
iajs-3642	49	19	succinohydrazide	succinohydrazide	NOUN
iajs-3642	49	20	(	(	PUNCT
iajs-3642	49	21	2b	2b	NOUN
iajs-3642	49	22	)	)	PUNCT
iajs-3642	49	23	succinohydrazide	succinohydrazide	NOUN
iajs-3642	49	24	was	be	AUX
iajs-3642	49	25	put	put	VERB
iajs-3642	49	26	in	in	ADP
iajs-3642	49	27	a	a	DET
iajs-3642	49	28	round	round	ADJ
iajs-3642	49	29	bottom	bottom	ADJ
iajs-3642	49	30	flask	flask	NOUN
iajs-3642	49	31	fixed	fix	VERB
iajs-3642	49	32	in	in	ADP
iajs-3642	49	33	an	an	DET
iajs-3642	49	34	ice	ice	NOUN
iajs-3642	49	35	bath	bath	NOUN
iajs-3642	49	36	(	(	PUNCT
iajs-3642	49	37	0.6	0.6	NUM
iajs-3642	49	38	g	g	NOUN
iajs-3642	49	39	,	,	PUNCT
iajs-3642	49	40	4	4	NUM
iajs-3642	49	41	mmol	mmol	NOUN
iajs-3642	49	42	)	)	PUNCT
iajs-3642	49	43	with	with	ADP
iajs-3642	49	44	15	15	NUM
iajs-3642	49	45	ml	ml	NOUN
iajs-3642	49	46	of	of	ADP
iajs-3642	49	47	thf	thf	NOUN
iajs-3642	49	48	as	as	ADP
iajs-3642	49	49	a	a	DET
iajs-3642	49	50	reaction	reaction	NOUN
iajs-3642	49	51	solvent	solvent	NOUN
iajs-3642	49	52	,	,	PUNCT
iajs-3642	49	53	and	and	CCONJ
iajs-3642	49	54	the	the	DET
iajs-3642	49	55	mixture	mixture	NOUN
iajs-3642	49	56	was	be	AUX
iajs-3642	49	57	homogenized	homogenize	VERB
iajs-3642	49	58	using	use	VERB
iajs-3642	49	59	a	a	DET
iajs-3642	49	60	magnetic	magnetic	ADJ
iajs-3642	49	61	stirrer	stirrer	NOUN
iajs-3642	49	62	.	.	PUNCT
iajs-3642	50	1	an	an	DET
iajs-3642	50	2	(	(	PUNCT
iajs-3642	50	3	8	8	NUM
iajs-3642	50	4	mmol	mmol	NOUN
iajs-3642	50	5	)	)	PUNCT
iajs-3642	50	6	of	of	ADP
iajs-3642	50	7	(	(	PUNCT
iajs-3642	50	8	benzoyl	benzoyl	ADJ
iajs-3642	50	9	chloride	chloride	NOUN
iajs-3642	50	10	or	or	CCONJ
iajs-3642	50	11	pmethoxybenzoylchloride	pmethoxybenzoylchloride	NOUN
iajs-3642	50	12	)	)	PUNCT
iajs-3642	50	13	was	be	AUX
iajs-3642	50	14	introduced	introduce	VERB
iajs-3642	50	15	dropwise	dropwise	NOUN
iajs-3642	50	16	with	with	ADP
iajs-3642	50	17	steady	steady	ADJ
iajs-3642	50	18	stirring	stirring	NOUN
iajs-3642	50	19	at	at	ADP
iajs-3642	50	20	0˚c	0˚c	NUM
iajs-3642	50	21	for	for	ADP
iajs-3642	50	22	1	1	NUM
iajs-3642	50	23	hour	hour	NOUN
iajs-3642	50	24	.	.	PUNCT
iajs-3642	51	1	tlc	tlc	NOUN
iajs-3642	51	2	checked	check	VERB
iajs-3642	51	3	the	the	DET
iajs-3642	51	4	reaction	reaction	NOUN
iajs-3642	51	5	,	,	PUNCT
iajs-3642	51	6	and	and	CCONJ
iajs-3642	51	7	when	when	SCONJ
iajs-3642	51	8	the	the	DET
iajs-3642	51	9	reaction	reaction	NOUN
iajs-3642	51	10	was	be	AUX
iajs-3642	51	11	done	do	VERB
iajs-3642	51	12	,	,	PUNCT
iajs-3642	51	13	it	it	PRON
iajs-3642	51	14	was	be	AUX
iajs-3642	51	15	neutralized	neutralize	VERB
iajs-3642	51	16	by	by	ADP
iajs-3642	51	17	adding	add	VERB
iajs-3642	51	18	5	5	NUM
iajs-3642	51	19	%	%	NOUN
iajs-3642	51	20	sodium	sodium	NOUN
iajs-3642	51	21	bicarbonate	bicarbonate	NOUN
iajs-3642	51	22	solution	solution	NOUN
iajs-3642	51	23	until	until	SCONJ
iajs-3642	51	24	it	it	PRON
iajs-3642	51	25	neutralized	neutralize	VERB
iajs-3642	51	26	and	and	CCONJ
iajs-3642	51	27	was	be	AUX
iajs-3642	51	28	allowed	allow	VERB
iajs-3642	51	29	to	to	PART
iajs-3642	51	30	settle	settle	VERB
iajs-3642	51	31	down	down	ADP
iajs-3642	51	32	.	.	PUNCT
iajs-3642	52	1	finally	finally	ADV
iajs-3642	52	2	,	,	PUNCT
iajs-3642	52	3	after	after	ADP
iajs-3642	52	4	filtering	filter	VERB
iajs-3642	52	5	out	out	ADP
iajs-3642	52	6	the	the	DET
iajs-3642	52	7	separated	separate	VERB
iajs-3642	52	8	solid	solid	ADJ
iajs-3642	52	9	,	,	PUNCT
iajs-3642	52	10	the	the	DET
iajs-3642	52	11	solid	solid	ADJ
iajs-3642	52	12	was	be	AUX
iajs-3642	52	13	washed	wash	VERB
iajs-3642	52	14	with	with	ADP
iajs-3642	52	15	distilled	distil	VERB
iajs-3642	52	16	water	water	NOUN
iajs-3642	52	17	to	to	PART
iajs-3642	52	18	obtain	obtain	VERB
iajs-3642	52	19	compounds	compound	NOUN
iajs-3642	52	20	(	(	PUNCT
iajs-3642	52	21	2a	2a	NUM
iajs-3642	52	22	-	-	PUNCT
iajs-3642	52	23	b	b	NOUN
iajs-3642	52	24	)	)	PUNCT
iajs-3642	52	25	.	.	PUNCT
iajs-3642	53	1	table	table	NOUN
iajs-3642	53	2	1	1	NUM
iajs-3642	53	3	shows	show	VERB
iajs-3642	53	4	the	the	DET
iajs-3642	53	5	physical	physical	ADJ
iajs-3642	53	6	properties	property	NOUN
iajs-3642	53	7	(	(	PUNCT
iajs-3642	53	8	25	25	NUM
iajs-3642	53	9	)	)	PUNCT
iajs-3642	53	10	.	.	PUNCT
iajs-3642	54	1	2.3.1	2.3.1	X
iajs-3642	54	2	.	.	PUNCT
iajs-3642	54	3	n'1	n'1	PROPN
iajs-3642	54	4	,	,	PUNCT
iajs-3642	54	5	n'4	n'4	PROPN
iajs-3642	54	6	-	-	PUNCT
iajs-3642	54	7	dibenzoylsuccinohydrazide	dibenzoylsuccinohydrazide	PROPN
iajs-3642	54	8	(	(	PUNCT
iajs-3642	54	9	2a	2a	NUM
iajs-3642	54	10	)	)	PUNCT
iajs-3642	54	11	the	the	DET
iajs-3642	54	12	ft	ft	PROPN
iajs-3642	54	13	-	-	PUNCT
iajs-3642	54	14	ir	ir	PROPN
iajs-3642	54	15	(	(	PUNCT
iajs-3642	54	16	υ	υ	PROPN
iajs-3642	54	17	,	,	PUNCT
iajs-3642	54	18	cm-1	cm-1	NUM
iajs-3642	54	19	):	):	PUNCT
iajs-3642	54	20	3192	3192	NUM
iajs-3642	54	21	(	(	PUNCT
iajs-3642	54	22	n	n	CCONJ
iajs-3642	54	23	-	-	PUNCT
iajs-3642	54	24	h	h	NOUN
iajs-3642	54	25	)	)	PUNCT
iajs-3642	54	26	,	,	PUNCT
iajs-3642	54	27	3030	3030	NUM
iajs-3642	54	28	(	(	PUNCT
iajs-3642	54	29	c	c	NOUN
iajs-3642	54	30	-	-	PUNCT
iajs-3642	54	31	harom	harom	NOUN
iajs-3642	54	32	)	)	PUNCT
iajs-3642	54	33	,	,	PUNCT
iajs-3642	54	34	2933,2878	2933,2878	NUM
iajs-3642	54	35	(	(	PUNCT
iajs-3642	54	36	c	c	NOUN
iajs-3642	54	37	-	-	PUNCT
iajs-3642	54	38	haliph	haliph	NOUN
iajs-3642	54	39	.	.	PUNCT
iajs-3642	54	40	)	)	PUNCT
iajs-3642	54	41	,	,	PUNCT
iajs-3642	54	42	1692	1692	NUM
iajs-3642	54	43	(	(	PUNCT
iajs-3642	54	44	nhc	nhc	PROPN
iajs-3642	54	45	=	=	PRON
iajs-3642	54	46	oamide	oamide	NOUN
iajs-3642	54	47	ch2),1667	ch2),1667	PROPN
iajs-3642	54	48	(	(	PUNCT
iajs-3642	54	49	nhc	nhc	NOUN
iajs-3642	54	50	=	=	NOUN
iajs-3642	54	51	oamideph	oamideph	PROPN
iajs-3642	54	52	)	)	PUNCT
iajs-3642	54	53	,	,	PUNCT
iajs-3642	54	54	1594,1573	1594,1573	NUM
iajs-3642	54	55	(	(	PUNCT
iajs-3642	54	56	c	c	NOUN
iajs-3642	54	57	=	=	NOUN
iajs-3642	54	58	carom	carom	NOUN
iajs-3642	54	59	.	.	PUNCT
iajs-3642	54	60	)	)	PUNCT
iajs-3642	54	61	;	;	PUNCT
iajs-3642	54	62	1h	1h	NUM
iajs-3642	54	63	nmr	nmr	NOUN
iajs-3642	54	64	(	(	PUNCT
iajs-3642	54	65	h	h	NOUN
iajs-3642	54	66	,	,	PUNCT
iajs-3642	54	67	ppm	ppm	NUM
iajs-3642	54	68	):	):	PUNCT
iajs-3642	54	69	10.32	10.32	NUM
iajs-3642	54	70	(	(	PUNCT
iajs-3642	54	71	2h	2h	NUM
iajs-3642	54	72	,	,	PUNCT
iajs-3642	54	73	s	s	PROPN
iajs-3642	54	74	,	,	PUNCT
iajs-3642	54	75	nhc	nhc	PROPN
iajs-3642	54	76	=	=	PRON
iajs-3642	54	77	oph),9.96	oph),9.96	X
iajs-3642	54	78	(	(	PUNCT
iajs-3642	54	79	2h	2h	NUM
iajs-3642	54	80	,	,	PUNCT
iajs-3642	54	81	s	s	X
iajs-3642	54	82	,	,	PUNCT
iajs-3642	54	83	nh	nh	PROPN
iajs-3642	54	84	-	-	PUNCT
iajs-3642	54	85	c	c	NOUN
iajs-3642	54	86	=	=	NOUN
iajs-3642	54	87	och2	och2	PROPN
iajs-3642	54	88	)	)	PUNCT
iajs-3642	54	89	,	,	PUNCT
iajs-3642	54	90	7.95–7.47	7.95–7.47	NUM
iajs-3642	54	91	(	(	PUNCT
iajs-3642	54	92	10h	10h	NUM
iajs-3642	54	93	,	,	PUNCT
iajs-3642	54	94	m	m	PROPN
iajs-3642	54	95	,	,	PUNCT
iajs-3642	54	96	ar	ar	NOUN
iajs-3642	54	97	-	-	NOUN
iajs-3642	54	98	h	h	NOUN
iajs-3642	54	99	)	)	PUNCT
iajs-3642	54	100	,	,	PUNCT
iajs-3642	54	101	2.56	2.56	NUM
iajs-3642	54	102	-	-	SYM
iajs-3642	54	103	2.51	2.51	NUM
iajs-3642	54	104	(	(	PUNCT
iajs-3642	54	105	4h	4h	NUM
iajs-3642	54	106	,	,	PUNCT
iajs-3642	54	107	t	t	PROPN
iajs-3642	54	108	,	,	PUNCT
iajs-3642	54	109	ch2	ch2	PROPN
iajs-3642	54	110	)	)	PUNCT
iajs-3642	54	111	;	;	PUNCT
iajs-3642	54	112	13c	13c	X
iajs-3642	54	113	nmr	nmr	NOUN
iajs-3642	54	114	(	(	PUNCT
iajs-3642	54	115	c	c	NOUN
iajs-3642	54	116	,	,	PUNCT
iajs-3642	54	117	ppm	ppm	NUM
iajs-3642	54	118	):	):	PUNCT
iajs-3642	54	119	171.05	171.05	NUM
iajs-3642	54	120	(	(	PUNCT
iajs-3642	54	121	nhc	nhc	PROPN
iajs-3642	54	122	=	=	SYM
iajs-3642	54	123	oamidech2),165.92	oamidech2),165.92	PROPN
iajs-3642	54	124	(	(	PUNCT
iajs-3642	54	125	nhc	nhc	NOUN
iajs-3642	54	126	=	=	NOUN
iajs-3642	54	127	oamideph	oamideph	PROPN
iajs-3642	54	128	)	)	PUNCT
iajs-3642	54	129	,	,	PUNCT
iajs-3642	54	130	132.22	132.22	NUM
iajs-3642	54	131	-	-	SYM
iajs-3642	54	132	127.87	127.87	NUM
iajs-3642	54	133	(	(	PUNCT
iajs-3642	54	134	ar	ar	NOUN
iajs-3642	54	135	-	-	NOUN
iajs-3642	54	136	c	c	NOUN
iajs-3642	54	137	)	)	PUNCT
iajs-3642	54	138	,	,	PUNCT
iajs-3642	54	139	28.96	28.96	NUM
iajs-3642	54	140	(	(	PUNCT
iajs-3642	54	141	ch2	ch2	PROPN
iajs-3642	54	142	-	-	PUNCT
iajs-3642	54	143	ch2	ch2	NOUN
iajs-3642	54	144	)	)	PUNCT
iajs-3642	54	145	.	.	PUNCT
iajs-3642	55	1	2.3.2	2.3.2	X
iajs-3642	55	2	.	.	X
iajs-3642	55	3	n'1	n'1	PROPN
iajs-3642	55	4	,	,	PUNCT
iajs-3642	55	5	n'4	n'4	PROPN
iajs-3642	55	6	-	-	PUNCT
iajs-3642	55	7	bis	bis	X
iajs-3642	55	8	(	(	PUNCT
iajs-3642	55	9	4	4	NUM
iajs-3642	55	10	-	-	PUNCT
iajs-3642	55	11	methoxybenzoyl	methoxybenzoyl	NOUN
iajs-3642	55	12	)	)	PUNCT
iajs-3642	55	13	succinohydrazide	succinohydrazide	NOUN
iajs-3642	55	14	(	(	PUNCT
iajs-3642	55	15	2b	2b	NUM
iajs-3642	55	16	)	)	PUNCT
iajs-3642	55	17	the	the	DET
iajs-3642	55	18	ft	ft	PROPN
iajs-3642	55	19	-	-	PUNCT
iajs-3642	55	20	ir	ir	PROPN
iajs-3642	55	21	(	(	PUNCT
iajs-3642	55	22	υ	υ	PROPN
iajs-3642	55	23	,	,	PUNCT
iajs-3642	55	24	cm-1	cm-1	NUM
iajs-3642	55	25	):	):	PUNCT
iajs-3642	55	26	3208	3208	NUM
iajs-3642	55	27	(	(	PUNCT
iajs-3642	55	28	n	n	CCONJ
iajs-3642	55	29	-	-	PUNCT
iajs-3642	55	30	h	h	NOUN
iajs-3642	55	31	)	)	PUNCT
iajs-3642	55	32	,	,	PUNCT
iajs-3642	55	33	3021	3021	NUM
iajs-3642	55	34	(	(	PUNCT
iajs-3642	55	35	c	c	NOUN
iajs-3642	55	36	-	-	PUNCT
iajs-3642	55	37	harom	harom	NOUN
iajs-3642	55	38	.	.	PUNCT
iajs-3642	55	39	)	)	PUNCT
iajs-3642	55	40	,	,	PUNCT
iajs-3642	55	41	2977,2844	2977,2844	NUM
iajs-3642	55	42	(	(	PUNCT
iajs-3642	55	43	c	c	NOUN
iajs-3642	55	44	-	-	PUNCT
iajs-3642	55	45	haliph	haliph	NOUN
iajs-3642	55	46	.	.	PUNCT
iajs-3642	55	47	)	)	PUNCT
iajs-3642	55	48	,	,	PUNCT
iajs-3642	55	49	1686	1686	NUM
iajs-3642	55	50	(	(	PUNCT
iajs-3642	55	51	nhc	nhc	PROPN
iajs-3642	55	52	=	=	PRON
iajs-3642	55	53	oamide	oamide	NOUN
iajs-3642	55	54	ch2),1637	ch2),1637	PROPN
iajs-3642	55	55	(	(	PUNCT
iajs-3642	55	56	nhc	nhc	NOUN
iajs-3642	55	57	=	=	NOUN
iajs-3642	55	58	oamideph	oamideph	PROPN
iajs-3642	55	59	)	)	PUNCT
iajs-3642	55	60	,	,	PUNCT
iajs-3642	55	61	1606,1577	1606,1577	NUM
iajs-3642	55	62	(	(	PUNCT
iajs-3642	55	63	c	c	X
iajs-3642	55	64	=	=	NOUN
iajs-3642	55	65	carom	carom	NOUN
iajs-3642	55	66	.	.	PUNCT
iajs-3642	55	67	)	)	PUNCT
iajs-3642	56	1	1025,843	1025,843	NUM
iajs-3642	56	2	(	(	PUNCT
iajs-3642	56	3	p	p	NOUN
iajs-3642	56	4	-	-	PUNCT
iajs-3642	56	5	sub	sub	NOUN
iajs-3642	56	6	.	.	PUNCT
iajs-3642	56	7	)	)	PUNCT
iajs-3642	56	8	;	;	PUNCT
iajs-3642	56	9	1h	1h	NUM
iajs-3642	56	10	nmr	nmr	NOUN
iajs-3642	56	11	(	(	PUNCT
iajs-3642	56	12	h	h	NOUN
iajs-3642	56	13	,	,	PUNCT
iajs-3642	56	14	ppm	ppm	NUM
iajs-3642	56	15	):	):	PUNCT
iajs-3642	56	16	10.17	10.17	NUM
iajs-3642	56	17	(	(	PUNCT
iajs-3642	56	18	2h	2h	NUM
iajs-3642	56	19	,	,	PUNCT
iajs-3642	56	20	s	s	X
iajs-3642	56	21	,	,	PUNCT
iajs-3642	56	22	nh	nh	PROPN
iajs-3642	56	23	-	-	PUNCT
iajs-3642	56	24	c	c	NOUN
iajs-3642	56	25	=	=	NOUN
iajs-3642	56	26	oph),9.89	oph),9.89	X
iajs-3642	56	27	(	(	PUNCT
iajs-3642	56	28	2h	2h	NUM
iajs-3642	56	29	,	,	PUNCT
iajs-3642	56	30	s	s	X
iajs-3642	56	31	,	,	PUNCT
iajs-3642	56	32	nh	nh	PROPN
iajs-3642	56	33	-	-	PUNCT
iajs-3642	56	34	c	c	NOUN
iajs-3642	56	35	=	=	NOUN
iajs-3642	56	36	och2	och2	PROPN
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iajs-3642	56	38	,	,	PUNCT
iajs-3642	56	39	7.87–7.00	7.87–7.00	NUM
iajs-3642	56	40	(	(	PUNCT
iajs-3642	56	41	8h	8h	NUM
iajs-3642	56	42	,	,	PUNCT
iajs-3642	56	43	q	q	NOUN
iajs-3642	56	44	,	,	PUNCT
iajs-3642	56	45	ar	ar	NOUN
iajs-3642	56	46	-	-	NOUN
iajs-3642	56	47	h	h	NOUN
iajs-3642	56	48	)	)	PUNCT
iajs-3642	56	49	,	,	PUNCT
iajs-3642	56	50	3.81	3.81	NUM
iajs-3642	56	51	(	(	PUNCT
iajs-3642	56	52	6h	6h	NUM
iajs-3642	56	53	,	,	PUNCT
iajs-3642	56	54	s	s	X
iajs-3642	56	55	,	,	PUNCT
iajs-3642	56	56	och3	och3	ADJ
iajs-3642	56	57	)	)	PUNCT
iajs-3642	56	58	,	,	PUNCT
iajs-3642	56	59	2.61	2.61	NUM
iajs-3642	56	60	-	-	SYM
iajs-3642	56	61	2.54	2.54	NUM
iajs-3642	56	62	(	(	PUNCT
iajs-3642	56	63	4h	4h	NUM
iajs-3642	56	64	,	,	PUNCT
iajs-3642	56	65	t	t	PROPN
iajs-3642	56	66	,	,	PUNCT
iajs-3642	56	67	ch2	ch2	PROPN
iajs-3642	56	68	)	)	PUNCT
iajs-3642	56	69	;	;	PUNCT
iajs-3642	56	70	13c	13c	X
iajs-3642	56	71	nmr	nmr	NOUN
iajs-3642	56	72	(	(	PUNCT
iajs-3642	56	73	c	c	NOUN
iajs-3642	56	74	,	,	PUNCT
iajs-3642	56	75	ppm	ppm	NOUN
iajs-3642	56	76	):	):	PUNCT
iajs-3642	56	77	171.12	171.12	NUM
iajs-3642	56	78	(	(	PUNCT
iajs-3642	56	79	nhc	nhc	PROPN
iajs-3642	56	80	=	=	SYM
iajs-3642	56	81	oamidech2),165.46	oamidech2),165.46	PROPN
iajs-3642	56	82	(	(	PUNCT
iajs-3642	56	83	nhc	nhc	NOUN
iajs-3642	56	84	=	=	NOUN
iajs-3642	56	85	oamideph	oamideph	PROPN
iajs-3642	56	86	)	)	PUNCT
iajs-3642	56	87	,	,	PUNCT
iajs-3642	56	88	162.42	162.42	NUM
iajs-3642	56	89	-	-	SYM
iajs-3642	56	90	114.12	114.12	NUM
iajs-3642	56	91	(	(	PUNCT
iajs-3642	56	92	ar	ar	NOUN
iajs-3642	56	93	-	-	NOUN
iajs-3642	56	94	c	c	NOUN
iajs-3642	56	95	)	)	PUNCT
iajs-3642	56	96	,	,	PUNCT
iajs-3642	56	97	55.83	55.83	NUM
iajs-3642	56	98	och3	och3	ADJ
iajs-3642	56	99	,	,	PUNCT
iajs-3642	56	100	29.01(ch2	29.01(ch2	NUM
iajs-3642	56	101	-	-	PUNCT
iajs-3642	56	102	ch2	ch2	NOUN
iajs-3642	56	103	)	)	PUNCT
iajs-3642	56	104	.	.	PUNCT
iajs-3642	57	1	2.4	2.4	NUM
iajs-3642	57	2	.	.	PUNCT
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iajs-3642	57	4	of	of	ADP
iajs-3642	57	5	n'1,n'4	n'1,n'4	NUM
iajs-3642	57	6	-	-	PUNCT
iajs-3642	57	7	bis(2	bis(2	NOUN
iajs-3642	57	8	-	-	PUNCT
iajs-3642	57	9	chlorobenzoyl)succinohydrazide	chlorobenzoyl)succinohydrazide	ADJ
iajs-3642	57	10	(	(	PUNCT
iajs-3642	57	11	2c	2c	NOUN
iajs-3642	57	12	)	)	PUNCT
iajs-3642	57	13	,	,	PUNCT
iajs-3642	57	14	n'1,n'4	n'1,n'4	NUM
iajs-3642	57	15	-	-	PUNCT
iajs-3642	57	16	bis(3	bis(3	NOUN
iajs-3642	57	17	-	-	PUNCT
iajs-3642	57	18	chloro	chloro	NOUN
iajs-3642	57	19	benzoyl)succinohydrazide	benzoyl)succinohydrazide	NOUN
iajs-3642	57	20	(	(	PUNCT
iajs-3642	57	21	2d	2d	NOUN
iajs-3642	57	22	)	)	PUNCT
iajs-3642	57	23	,	,	PUNCT
iajs-3642	57	24	n'1,n'4	n'1,n'4	NUM
iajs-3642	57	25	-	-	PUNCT
iajs-3642	57	26	bis(4	bis(4	NOUN
iajs-3642	57	27	-	-	PUNCT
iajs-3642	57	28	chlorobenzoyl)succinohydrazide	chlorobenzoyl)succinohydrazide	ADJ
iajs-3642	57	29	(	(	PUNCT
iajs-3642	57	30	2e	2e	NOUN
iajs-3642	57	31	)	)	PUNCT
iajs-3642	57	32	ihjpas	ihjpas	PROPN
iajs-3642	57	33	.	.	PUNCT
iajs-3642	58	1	2025	2025	NUM
iajs-3642	58	2	,	,	PUNCT
iajs-3642	58	3	38	38	NUM
iajs-3642	58	4	(	(	PUNCT
iajs-3642	58	5	1	1	NUM
iajs-3642	58	6	)	)	PUNCT
iajs-3642	58	7	316	316	NUM
iajs-3642	58	8	a	a	DET
iajs-3642	58	9	100	100	NUM
iajs-3642	58	10	ml	ml	NOUN
iajs-3642	58	11	one	one	NUM
iajs-3642	58	12	-	-	PUNCT
iajs-3642	58	13	neck	neck	NOUN
iajs-3642	58	14	round	round	NOUN
iajs-3642	58	15	bottom	bottom	ADJ
iajs-3642	58	16	flask	flask	NOUN
iajs-3642	58	17	was	be	AUX
iajs-3642	58	18	attached	attach	VERB
iajs-3642	58	19	to	to	ADP
iajs-3642	58	20	a	a	DET
iajs-3642	58	21	reflux	reflux	NOUN
iajs-3642	58	22	condenser	condenser	NOUN
iajs-3642	58	23	(	(	PUNCT
iajs-3642	58	24	0.3	0.3	NUM
iajs-3642	58	25	g	g	NOUN
iajs-3642	58	26	,	,	PUNCT
iajs-3642	58	27	2	2	NUM
iajs-3642	58	28	mmol	mmol	NOUN
iajs-3642	58	29	)	)	PUNCT
iajs-3642	58	30	of	of	ADP
iajs-3642	58	31	each	each	DET
iajs-3642	58	32	different	different	ADJ
iajs-3642	58	33	substituted	substitute	VERB
iajs-3642	58	34	chloro	chloro	NOUN
iajs-3642	58	35	benzoic	benzoic	NOUN
iajs-3642	58	36	acid	acid	NOUN
iajs-3642	58	37	,	,	PUNCT
iajs-3642	58	38	then	then	ADV
iajs-3642	58	39	added	add	VERB
iajs-3642	58	40	(	(	PUNCT
iajs-3642	58	41	2.5	2.5	NUM
iajs-3642	58	42	ml	ml	NOUN
iajs-3642	58	43	,	,	PUNCT
iajs-3642	58	44	3	3	NUM
iajs-3642	58	45	mmol	mmol	NOUN
iajs-3642	58	46	)	)	PUNCT
iajs-3642	58	47	of	of	ADP
iajs-3642	58	48	thionyl	thionyl	ADJ
iajs-3642	58	49	chloride	chloride	NOUN
iajs-3642	58	50	.	.	PUNCT
iajs-3642	59	1	the	the	DET
iajs-3642	59	2	reaction	reaction	NOUN
iajs-3642	59	3	was	be	AUX
iajs-3642	59	4	performed	perform	VERB
iajs-3642	59	5	under	under	ADP
iajs-3642	59	6	reflux	reflux	NOUN
iajs-3642	59	7	conditions	condition	NOUN
iajs-3642	59	8	for	for	ADP
iajs-3642	59	9	3	3	NUM
iajs-3642	59	10	hours	hour	NOUN
iajs-3642	59	11	to	to	PART
iajs-3642	59	12	obtain	obtain	VERB
iajs-3642	59	13	the	the	DET
iajs-3642	59	14	corresponding	corresponding	ADJ
iajs-3642	59	15	acid	acid	NOUN
iajs-3642	59	16	chloride	chloride	NOUN
iajs-3642	59	17	.	.	PUNCT
iajs-3642	60	1	the	the	DET
iajs-3642	60	2	excess	excess	NOUN
iajs-3642	60	3	of	of	ADP
iajs-3642	60	4	thionyl	thionyl	ADJ
iajs-3642	60	5	chloride	chloride	NOUN
iajs-3642	60	6	was	be	AUX
iajs-3642	60	7	evaporated	evaporate	VERB
iajs-3642	60	8	,	,	PUNCT
iajs-3642	60	9	and	and	CCONJ
iajs-3642	60	10	without	without	ADP
iajs-3642	60	11	separation	separation	NOUN
iajs-3642	60	12	,	,	PUNCT
iajs-3642	60	13	succinohydrazide	succinohydrazide	ADV
iajs-3642	60	14	(	(	PUNCT
iajs-3642	60	15	1	1	X
iajs-3642	60	16	)	)	PUNCT
iajs-3642	60	17	was	be	AUX
iajs-3642	60	18	added	add	VERB
iajs-3642	60	19	,	,	PUNCT
iajs-3642	60	20	followed	follow	VERB
iajs-3642	60	21	by	by	ADP
iajs-3642	60	22	continuous	continuous	ADJ
iajs-3642	60	23	reflux	reflux	NOUN
iajs-3642	60	24	for	for	ADP
iajs-3642	60	25	(	(	PUNCT
iajs-3642	60	26	3	3	NUM
iajs-3642	60	27	-	-	SYM
iajs-3642	60	28	6	6	NUM
iajs-3642	60	29	)	)	PUNCT
iajs-3642	60	30	hours	hour	NOUN
iajs-3642	60	31	.	.	PUNCT
iajs-3642	61	1	check	check	VERB
iajs-3642	61	2	the	the	DET
iajs-3642	61	3	end	end	NOUN
iajs-3642	61	4	of	of	ADP
iajs-3642	61	5	the	the	DET
iajs-3642	61	6	reaction	reaction	NOUN
iajs-3642	61	7	by	by	ADP
iajs-3642	61	8	tlc	tlc	PROPN
iajs-3642	61	9	.	.	PUNCT
iajs-3642	62	1	the	the	DET
iajs-3642	62	2	product	product	NOUN
iajs-3642	62	3	(	(	PUNCT
iajs-3642	62	4	2c-2e	2c-2e	NOUN
iajs-3642	62	5	)	)	PUNCT
iajs-3642	62	6	was	be	AUX
iajs-3642	62	7	obtained	obtain	VERB
iajs-3642	62	8	as	as	ADP
iajs-3642	62	9	crystals	crystal	NOUN
iajs-3642	62	10	.	.	PUNCT
iajs-3642	63	1	physical	physical	ADJ
iajs-3642	63	2	properties	property	NOUN
iajs-3642	63	3	are	be	AUX
iajs-3642	63	4	shown	show	VERB
iajs-3642	63	5	in	in	ADP
iajs-3642	63	6	table	table	NOUN
iajs-3642	63	7	1	1	NUM
iajs-3642	63	8	(	(	PUNCT
iajs-3642	63	9	26	26	NUM
iajs-3642	63	10	)	)	PUNCT
iajs-3642	63	11	.	.	PUNCT
iajs-3642	64	1	2.4.1	2.4.1	X
iajs-3642	64	2	.	.	PUNCT
iajs-3642	64	3	n'1	n'1	PROPN
iajs-3642	64	4	,	,	PUNCT
iajs-3642	64	5	n'4	n'4	PROPN
iajs-3642	64	6	-	-	PUNCT
iajs-3642	64	7	bis	bis	X
iajs-3642	64	8	(	(	PUNCT
iajs-3642	64	9	2	2	NUM
iajs-3642	64	10	-	-	PUNCT
iajs-3642	64	11	chlorobenzoyl	chlorobenzoyl	NOUN
iajs-3642	64	12	)	)	PUNCT
iajs-3642	64	13	succinohydrazide	succinohydrazide	NOUN
iajs-3642	64	14	(	(	PUNCT
iajs-3642	64	15	2c	2c	NUM
iajs-3642	64	16	)	)	PUNCT
iajs-3642	64	17	the	the	DET
iajs-3642	64	18	ft	ft	PROPN
iajs-3642	64	19	-	-	PUNCT
iajs-3642	64	20	ir	ir	PROPN
iajs-3642	64	21	(	(	PUNCT
iajs-3642	64	22	υ	υ	PROPN
iajs-3642	64	23	,	,	PUNCT
iajs-3642	64	24	cm-1	cm-1	NUM
iajs-3642	64	25	):	):	PUNCT
iajs-3642	64	26	3202	3202	NUM
iajs-3642	64	27	(	(	PUNCT
iajs-3642	64	28	n	n	CCONJ
iajs-3642	64	29	-	-	PUNCT
iajs-3642	64	30	h	h	NOUN
iajs-3642	64	31	)	)	PUNCT
iajs-3642	64	32	,	,	PUNCT
iajs-3642	64	33	3081	3081	NUM
iajs-3642	64	34	(	(	PUNCT
iajs-3642	64	35	c	c	NOUN
iajs-3642	64	36	-	-	PUNCT
iajs-3642	64	37	harom	harom	NOUN
iajs-3642	64	38	.	.	PUNCT
iajs-3642	64	39	)	)	PUNCT
iajs-3642	64	40	,	,	PUNCT
iajs-3642	64	41	2929	2929	NUM
iajs-3642	64	42	,	,	PUNCT
iajs-3642	64	43	2855	2855	NUM
iajs-3642	64	44	(	(	PUNCT
iajs-3642	64	45	c	c	NOUN
iajs-3642	64	46	-	-	PUNCT
iajs-3642	64	47	haliph	haliph	NOUN
iajs-3642	64	48	.	.	PUNCT
iajs-3642	64	49	)	)	PUNCT
iajs-3642	64	50	,	,	PUNCT
iajs-3642	64	51	1698	1698	NUM
iajs-3642	64	52	(	(	PUNCT
iajs-3642	64	53	nhc	nhc	PROPN
iajs-3642	64	54	=	=	PUNCT
iajs-3642	64	55	oamide	oamide	NOUN
iajs-3642	64	56	ch2	ch2	PROPN
iajs-3642	64	57	)	)	PUNCT
iajs-3642	64	58	,	,	PUNCT
iajs-3642	64	59	1622	1622	NUM
iajs-3642	64	60	(	(	PUNCT
iajs-3642	64	61	nhc	nhc	NOUN
iajs-3642	64	62	=	=	NOUN
iajs-3642	64	63	oamideph	oamideph	PROPN
iajs-3642	64	64	)	)	PUNCT
iajs-3642	64	65	,	,	PUNCT
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iajs-3642	64	67	,	,	PUNCT
iajs-3642	64	68	1576	1576	NUM
iajs-3642	64	69	(	(	PUNCT
iajs-3642	64	70	c	c	NOUN
iajs-3642	64	71	=	=	NOUN
iajs-3642	64	72	carom	carom	NOUN
iajs-3642	64	73	.	.	PUNCT
iajs-3642	64	74	)	)	PUNCT
iajs-3642	65	1	1098,831	1098,831	NUM
iajs-3642	66	1	(	(	PUNCT
iajs-3642	66	2	o	o	NOUN
iajs-3642	66	3	-	-	NOUN
iajs-3642	66	4	sub	sub	NOUN
iajs-3642	66	5	.	.	PUNCT
iajs-3642	66	6	)	)	PUNCT
iajs-3642	66	7	.	.	PUNCT
iajs-3642	67	1	2.4.2	2.4.2	X
iajs-3642	67	2	.	.	X
iajs-3642	67	3	n'1	n'1	PROPN
iajs-3642	67	4	,	,	PUNCT
iajs-3642	67	5	n'4	n'4	PROPN
iajs-3642	67	6	-	-	PUNCT
iajs-3642	67	7	bis	bis	X
iajs-3642	67	8	(	(	PUNCT
iajs-3642	67	9	3	3	NUM
iajs-3642	67	10	-	-	PUNCT
iajs-3642	67	11	chlorobenzoyl	chlorobenzoyl	NOUN
iajs-3642	67	12	)	)	PUNCT
iajs-3642	67	13	succinohydrazide	succinohydrazide	NOUN
iajs-3642	67	14	(	(	PUNCT
iajs-3642	67	15	2d	2d	NUM
iajs-3642	67	16	)	)	PUNCT
iajs-3642	67	17	the	the	DET
iajs-3642	67	18	ft	ft	PROPN
iajs-3642	67	19	-	-	PUNCT
iajs-3642	67	20	ir	ir	PROPN
iajs-3642	67	21	(	(	PUNCT
iajs-3642	67	22	υ	υ	PROPN
iajs-3642	67	23	,	,	PUNCT
iajs-3642	67	24	cm-1	cm-1	NUM
iajs-3642	67	25	):	):	PUNCT
iajs-3642	67	26	3207	3207	NUM
iajs-3642	67	27	(	(	PUNCT
iajs-3642	67	28	n	n	CCONJ
iajs-3642	67	29	-	-	PUNCT
iajs-3642	67	30	h	h	NOUN
iajs-3642	67	31	)	)	PUNCT
iajs-3642	67	32	,	,	PUNCT
iajs-3642	67	33	3031	3031	NUM
iajs-3642	67	34	(	(	PUNCT
iajs-3642	67	35	c	c	NOUN
iajs-3642	67	36	-	-	PUNCT
iajs-3642	67	37	harom	harom	NOUN
iajs-3642	67	38	.	.	PUNCT
iajs-3642	67	39	)	)	PUNCT
iajs-3642	67	40	,	,	PUNCT
iajs-3642	67	41	2950,2870	2950,2870	PROPN
iajs-3642	67	42	(	(	PUNCT
iajs-3642	67	43	c	c	NOUN
iajs-3642	67	44	-	-	PUNCT
iajs-3642	67	45	haliph	haliph	NOUN
iajs-3642	67	46	.	.	PUNCT
iajs-3642	67	47	)	)	PUNCT
iajs-3642	67	48	,	,	PUNCT
iajs-3642	67	49	1686	1686	NUM
iajs-3642	67	50	(	(	PUNCT
iajs-3642	67	51	nhc	nhc	PROPN
iajs-3642	67	52	=	=	SYM
iajs-3642	67	53	oamidech2	oamidech2	PROPN
iajs-3642	67	54	)	)	PUNCT
iajs-3642	67	55	,	,	PUNCT
iajs-3642	67	56	1638	1638	NUM
iajs-3642	67	57	(	(	PUNCT
iajs-3642	67	58	nhc	nhc	NOUN
iajs-3642	67	59	=	=	SYM
iajs-3642	67	60	oamideph),1597,1570	oamideph),1597,1570	NOUN
iajs-3642	67	61	(	(	PUNCT
iajs-3642	67	62	c	c	NOUN
iajs-3642	67	63	=	=	NOUN
iajs-3642	67	64	carom	carom	NOUN
iajs-3642	67	65	.	.	PUNCT
iajs-3642	67	66	)	)	PUNCT
iajs-3642	67	67	1138	1138	NUM
iajs-3642	67	68	,	,	PUNCT
iajs-3642	67	69	897	897	NUM
iajs-3642	67	70	(	(	PUNCT
iajs-3642	67	71	m	m	NOUN
iajs-3642	67	72	-	-	PUNCT
iajs-3642	67	73	sub	sub	NOUN
iajs-3642	67	74	.	.	PUNCT
iajs-3642	67	75	)	)	PUNCT
iajs-3642	67	76	;	;	PUNCT
iajs-3642	67	77	1h	1h	NUM
iajs-3642	67	78	nmr	nmr	NOUN
iajs-3642	67	79	(	(	PUNCT
iajs-3642	67	80	h	h	PROPN
iajs-3642	67	81	,	,	PUNCT
iajs-3642	67	82	ppm	ppm	NUM
iajs-3642	67	83	):	):	PUNCT
iajs-3642	67	84	10.47(2h	10.47(2h	NUM
iajs-3642	67	85	,	,	PUNCT
iajs-3642	67	86	s	s	PART
iajs-3642	67	87	,	,	PUNCT
iajs-3642	67	88	nh	nh	PROPN
iajs-3642	67	89	-	-	PUNCT
iajs-3642	67	90	c	c	NOUN
iajs-3642	67	91	=	=	NOUN
iajs-3642	67	92	oph),10.04	oph),10.04	NOUN
iajs-3642	67	93	(	(	PUNCT
iajs-3642	67	94	2h	2h	NUM
iajs-3642	67	95	,	,	PUNCT
iajs-3642	67	96	s	s	PART
iajs-3642	67	97	,	,	PUNCT
iajs-3642	67	98	nh	nh	PROPN
iajs-3642	67	99	-	-	PUNCT
iajs-3642	67	100	c	c	NOUN
iajs-3642	67	101	=	=	NOUN
iajs-3642	67	102	och2	och2	PROPN
iajs-3642	67	103	)	)	PUNCT
iajs-3642	67	104	,	,	PUNCT
iajs-3642	67	105	7.87	7.87	NUM
iajs-3642	67	106	–	–	PUNCT
iajs-3642	67	107	7.49	7.49	NUM
iajs-3642	67	108	(	(	PUNCT
iajs-3642	67	109	8h	8h	NUM
iajs-3642	67	110	,	,	PUNCT
iajs-3642	67	111	m	m	PROPN
iajs-3642	67	112	,	,	PUNCT
iajs-3642	67	113	ar	ar	NOUN
iajs-3642	67	114	-	-	NOUN
iajs-3642	67	115	h	h	NOUN
iajs-3642	67	116	)	)	PUNCT
iajs-3642	67	117	,	,	PUNCT
iajs-3642	67	118	2.57	2.57	NUM
iajs-3642	67	119	-	-	SYM
iajs-3642	67	120	2.53	2.53	NUM
iajs-3642	67	121	(	(	PUNCT
iajs-3642	67	122	4h	4h	NUM
iajs-3642	67	123	,	,	PUNCT
iajs-3642	67	124	t	t	PROPN
iajs-3642	67	125	,	,	PUNCT
iajs-3642	67	126	ch2	ch2	PROPN
iajs-3642	67	127	)	)	PUNCT
iajs-3642	67	128	;	;	PUNCT
iajs-3642	67	129	13c	13c	X
iajs-3642	67	130	nmr	nmr	NOUN
iajs-3642	67	131	(	(	PUNCT
iajs-3642	67	132	c	c	NOUN
iajs-3642	67	133	,	,	PUNCT
iajs-3642	67	134	ppm	ppm	NOUN
iajs-3642	67	135	):	):	PUNCT
iajs-3642	67	136	170.98	170.98	NUM
iajs-3642	67	137	(	(	PUNCT
iajs-3642	67	138	nhc	nhc	PROPN
iajs-3642	67	139	=	=	SYM
iajs-3642	67	140	oamidech2	oamidech2	PROPN
iajs-3642	67	141	)	)	PUNCT
iajs-3642	67	142	,	,	PUNCT
iajs-3642	67	143	164.53	164.53	NUM
iajs-3642	67	144	(	(	PUNCT
iajs-3642	67	145	nhc	nhc	NOUN
iajs-3642	67	146	=	=	SYM
iajs-3642	67	147	oamideph	oamideph	PROPN
iajs-3642	67	148	)	)	PUNCT
iajs-3642	67	149	,	,	PUNCT
iajs-3642	67	150	134.89	134.89	NUM
iajs-3642	67	151	-	-	SYM
iajs-3642	67	152	127.70	127.70	NUM
iajs-3642	67	153	(	(	PUNCT
iajs-3642	67	154	ar	ar	NOUN
iajs-3642	67	155	-	-	NOUN
iajs-3642	67	156	c	c	NOUN
iajs-3642	67	157	)	)	PUNCT
iajs-3642	67	158	,	,	PUNCT
iajs-3642	67	159	28.88(ch2	28.88(ch2	PROPN
iajs-3642	67	160	-	-	PUNCT
iajs-3642	67	161	ch2	ch2	NOUN
iajs-3642	67	162	)	)	PUNCT
iajs-3642	67	163	.	.	PUNCT
iajs-3642	68	1	2.4.3	2.4.3	X
iajs-3642	68	2	.	.	PUNCT
iajs-3642	68	3	n'1	n'1	PROPN
iajs-3642	68	4	,	,	PUNCT
iajs-3642	68	5	n'4	n'4	PROPN
iajs-3642	68	6	-	-	PUNCT
iajs-3642	68	7	bis	bis	X
iajs-3642	68	8	(	(	PUNCT
iajs-3642	68	9	4	4	NUM
iajs-3642	68	10	-	-	PUNCT
iajs-3642	68	11	chlorobenzoyl	chlorobenzoyl	NOUN
iajs-3642	68	12	)	)	PUNCT
iajs-3642	68	13	succinohydrazide	succinohydrazide	NOUN
iajs-3642	68	14	(	(	PUNCT
iajs-3642	68	15	2e	2e	NUM
iajs-3642	68	16	)	)	PUNCT
iajs-3642	68	17	the	the	DET
iajs-3642	68	18	ft	ft	PROPN
iajs-3642	68	19	-	-	PUNCT
iajs-3642	68	20	ir	ir	PROPN
iajs-3642	68	21	(	(	PUNCT
iajs-3642	68	22	υ	υ	PROPN
iajs-3642	68	23	,	,	PUNCT
iajs-3642	68	24	cm-1	cm-1	NUM
iajs-3642	68	25	):	):	PUNCT
iajs-3642	68	26	3174	3174	NUM
iajs-3642	68	27	(	(	PUNCT
iajs-3642	68	28	n	n	CCONJ
iajs-3642	68	29	-	-	PUNCT
iajs-3642	68	30	h	h	NOUN
iajs-3642	68	31	)	)	PUNCT
iajs-3642	68	32	,	,	PUNCT
iajs-3642	68	33	3048	3048	NUM
iajs-3642	68	34	(	(	PUNCT
iajs-3642	68	35	c	c	NOUN
iajs-3642	68	36	-	-	PUNCT
iajs-3642	68	37	harom	harom	NOUN
iajs-3642	68	38	.	.	PUNCT
iajs-3642	68	39	)	)	PUNCT
iajs-3642	68	40	,	,	PUNCT
iajs-3642	68	41	2922	2922	NUM
iajs-3642	68	42	,	,	PUNCT
iajs-3642	68	43	2850	2850	NUM
iajs-3642	68	44	(	(	PUNCT
iajs-3642	68	45	c	c	NOUN
iajs-3642	68	46	-	-	PUNCT
iajs-3642	68	47	haliph	haliph	NOUN
iajs-3642	68	48	.	.	PUNCT
iajs-3642	68	49	)	)	PUNCT
iajs-3642	68	50	,	,	PUNCT
iajs-3642	68	51	1679	1679	NUM
iajs-3642	68	52	(	(	PUNCT
iajs-3642	68	53	nhc	nhc	NOUN
iajs-3642	68	54	=	=	PUNCT
iajs-3642	68	55	oamide	oamide	NOUN
iajs-3642	68	56	ch2	ch2	PROPN
iajs-3642	68	57	)	)	PUNCT
iajs-3642	68	58	,	,	PUNCT
iajs-3642	68	59	1639	1639	NUM
iajs-3642	68	60	(	(	PUNCT
iajs-3642	68	61	nhc	nhc	NOUN
iajs-3642	68	62	=	=	SYM
iajs-3642	68	63	oamideph	oamideph	PROPN
iajs-3642	68	64	)	)	PUNCT
iajs-3642	68	65	,	,	PUNCT
iajs-3642	68	66	1591,1573	1591,1573	NUM
iajs-3642	68	67	(	(	PUNCT
iajs-3642	68	68	c	c	NOUN
iajs-3642	68	69	=	=	NOUN
iajs-3642	68	70	carom	carom	NOUN
iajs-3642	68	71	.	.	PUNCT
iajs-3642	68	72	)	)	PUNCT
iajs-3642	68	73	1091,850	1091,850	NUM
iajs-3642	68	74	(	(	PUNCT
iajs-3642	68	75	p	p	NOUN
iajs-3642	68	76	-	-	PUNCT
iajs-3642	68	77	sub	sub	NOUN
iajs-3642	68	78	)	)	PUNCT
iajs-3642	68	79	;	;	PUNCT
iajs-3642	68	80	1h	1h	NUM
iajs-3642	68	81	nmr	nmr	NOUN
iajs-3642	68	82	(	(	PUNCT
iajs-3642	68	83	h	h	PROPN
iajs-3642	68	84	,	,	PUNCT
iajs-3642	68	85	ppm	ppm	NUM
iajs-3642	68	86	):	):	PUNCT
iajs-3642	68	87	10.39	10.39	NUM
iajs-3642	68	88	(	(	PUNCT
iajs-3642	68	89	2h	2h	NUM
iajs-3642	68	90	,	,	PUNCT
iajs-3642	68	91	s	s	NOUN
iajs-3642	68	92	,	,	PUNCT
iajs-3642	68	93	phnh	phnh	NOUN
iajs-3642	68	94	-	-	PUNCT
iajs-3642	68	95	c	c	NOUN
iajs-3642	68	96	=	=	NOUN
iajs-3642	68	97	o	o	NOUN
iajs-3642	68	98	)	)	PUNCT
iajs-3642	68	99	,	,	PUNCT
iajs-3642	68	100	9.96	9.96	NUM
iajs-3642	68	101	(	(	PUNCT
iajs-3642	68	102	2h	2h	NUM
iajs-3642	68	103	,	,	PUNCT
iajs-3642	68	104	s	s	X
iajs-3642	68	105	,	,	PUNCT
iajs-3642	68	106	ch2nh	ch2nh	NOUN
iajs-3642	68	107	-	-	PUNCT
iajs-3642	68	108	c	c	NOUN
iajs-3642	68	109	=	=	NOUN
iajs-3642	68	110	o	o	NOUN
iajs-3642	68	111	)	)	PUNCT
iajs-3642	68	112	,	,	PUNCT
iajs-3642	68	113	7.91	7.91	NUM
iajs-3642	68	114	–	–	PUNCT
iajs-3642	68	115	7.52	7.52	NUM
iajs-3642	68	116	(	(	PUNCT
iajs-3642	68	117	8h	8h	NUM
iajs-3642	68	118	,	,	PUNCT
iajs-3642	68	119	q	q	NOUN
iajs-3642	68	120	,	,	PUNCT
iajs-3642	68	121	ar	ar	NOUN
iajs-3642	68	122	-	-	NOUN
iajs-3642	68	123	h	h	NOUN
iajs-3642	68	124	)	)	PUNCT
iajs-3642	68	125	,	,	PUNCT
iajs-3642	68	126	2.82	2.82	NUM
iajs-3642	68	127	-	-	SYM
iajs-3642	68	128	2.47	2.47	NUM
iajs-3642	68	129	(	(	PUNCT
iajs-3642	68	130	4h	4h	NUM
iajs-3642	68	131	,	,	PUNCT
iajs-3642	68	132	t	t	PROPN
iajs-3642	68	133	,	,	PUNCT
iajs-3642	68	134	ch2	ch2	PROPN
iajs-3642	68	135	)	)	PUNCT
iajs-3642	68	136	;	;	PUNCT
iajs-3642	68	137	13c	13c	X
iajs-3642	68	138	nmr	nmr	NOUN
iajs-3642	68	139	(	(	PUNCT
iajs-3642	68	140	c	c	NOUN
iajs-3642	68	141	,	,	PUNCT
iajs-3642	68	142	ppm):174.01(ch2nhc	ppm):174.01(ch2nhc	NOUN
iajs-3642	68	143	=	=	NOUN
iajs-3642	68	144	oamide),166.88	oamide),166.88	ADJ
iajs-3642	68	145	(	(	PUNCT
iajs-3642	68	146	phnhc	phnhc	NOUN
iajs-3642	68	147	=	=	NOUN
iajs-3642	68	148	oamide	oamide	ADV
iajs-3642	68	149	)	)	PUNCT
iajs-3642	68	150	,	,	PUNCT
iajs-3642	68	151	138.23	138.23	NUM
iajs-3642	68	152	-	-	SYM
iajs-3642	68	153	129.21	129.21	NUM
iajs-3642	68	154	(	(	PUNCT
iajs-3642	68	155	ar	ar	NOUN
iajs-3642	68	156	-	-	NOUN
iajs-3642	68	157	c	c	NOUN
iajs-3642	68	158	)	)	PUNCT
iajs-3642	68	159	,	,	PUNCT
iajs-3642	68	160	29.23	29.23	NUM
iajs-3642	68	161	(	(	PUNCT
iajs-3642	68	162	ch2	ch2	PROPN
iajs-3642	68	163	-	-	PUNCT
iajs-3642	68	164	ch2	ch2	NOUN
iajs-3642	68	165	)	)	PUNCT
iajs-3642	68	166	.	.	PUNCT
iajs-3642	69	1	2.5	2.5	NUM
iajs-3642	69	2	.	.	PUNCT
iajs-3642	70	1	succinyl	succinyl	NOUN
iajs-3642	70	2	dibenzenesulfonohydrazide	dibenzenesulfonohydrazide	ADJ
iajs-3642	70	3	derivatives	derivative	NOUN
iajs-3642	70	4	(	(	PUNCT
iajs-3642	70	5	3a	3a	NUM
iajs-3642	70	6	-	-	SYM
iajs-3642	70	7	c	c	NOUN
iajs-3642	70	8	)	)	PUNCT
iajs-3642	71	1	[	[	X
iajs-3642	71	2	10	10	NUM
iajs-3642	71	3	]	]	X
iajs-3642	71	4	a	a	DET
iajs-3642	71	5	mixture	mixture	NOUN
iajs-3642	71	6	of	of	ADP
iajs-3642	71	7	compound	compound	NOUN
iajs-3642	71	8	(	(	PUNCT
iajs-3642	71	9	1	1	NUM
iajs-3642	71	10	)	)	PUNCT
iajs-3642	71	11	(	(	PUNCT
iajs-3642	71	12	0.6	0.6	NUM
iajs-3642	71	13	g	g	NOUN
iajs-3642	71	14	,	,	PUNCT
iajs-3642	71	15	4	4	NUM
iajs-3642	71	16	mmol	mmol	NOUN
iajs-3642	71	17	)	)	PUNCT
iajs-3642	71	18	and	and	CCONJ
iajs-3642	71	19	various	various	ADJ
iajs-3642	71	20	substitutes	substitute	NOUN
iajs-3642	71	21	(	(	PUNCT
iajs-3642	71	22	benzene	benzene	ADJ
iajs-3642	71	23	sulphonyl	sulphonyl	NOUN
iajs-3642	71	24	chloride	chloride	NOUN
iajs-3642	71	25	,	,	PUNCT
iajs-3642	71	26	p	p	NOUN
iajs-3642	71	27	-	-	PUNCT
iajs-3642	71	28	bromo	bromo	NOUN
iajs-3642	71	29	benzene	benzene	NOUN
iajs-3642	71	30	sulphonyl	sulphonyl	NOUN
iajs-3642	71	31	chloride	chloride	NOUN
iajs-3642	71	32	(	(	PUNCT
iajs-3642	71	33	1.047	1.047	NUM
iajs-3642	71	34	ml	ml	NOUN
iajs-3642	71	35	,	,	PUNCT
iajs-3642	71	36	8	8	NUM
iajs-3642	71	37	mmol	mmol	NOUN
iajs-3642	71	38	)	)	PUNCT
iajs-3642	71	39	in	in	ADP
iajs-3642	71	40	ethanol	ethanol	NOUN
iajs-3642	71	41	(	(	PUNCT
iajs-3642	71	42	25	25	NUM
iajs-3642	71	43	ml	ml	NOUN
iajs-3642	71	44	)	)	PUNCT
iajs-3642	71	45	,	,	PUNCT
iajs-3642	71	46	and	and	CCONJ
iajs-3642	71	47	a	a	DET
iajs-3642	71	48	few	few	ADJ
iajs-3642	71	49	drops	drop	NOUN
iajs-3642	71	50	of	of	ADP
iajs-3642	71	51	gaa	gaa	PROPN
iajs-3642	71	52	were	be	AUX
iajs-3642	71	53	added	add	VERB
iajs-3642	71	54	and	and	CCONJ
iajs-3642	71	55	stirred	stir	VERB
iajs-3642	71	56	for	for	ADP
iajs-3642	71	57	(	(	PUNCT
iajs-3642	71	58	10	10	NUM
iajs-3642	71	59	-	-	SYM
iajs-3642	71	60	15	15	NUM
iajs-3642	71	61	min	min	NOUN
iajs-3642	71	62	)	)	PUNCT
iajs-3642	71	63	.	.	PUNCT
iajs-3642	72	1	in	in	ADP
iajs-3642	72	2	comparison	comparison	NOUN
iajs-3642	72	3	,	,	PUNCT
iajs-3642	72	4	p	p	NOUN
iajs-3642	72	5	-	-	PUNCT
iajs-3642	72	6	methylbenzene	methylbenzene	NOUN
iajs-3642	72	7	sulphonyl	sulphonyl	NOUN
iajs-3642	72	8	chloride	chloride	NOUN
iajs-3642	72	9	(	(	PUNCT
iajs-3642	72	10	1.525	1.525	NUM
iajs-3642	72	11	g	g	NOUN
iajs-3642	72	12	,	,	PUNCT
iajs-3642	72	13	8	8	NUM
iajs-3642	72	14	mmol	mmol	NOUN
iajs-3642	72	15	)	)	PUNCT
iajs-3642	72	16	in	in	ADP
iajs-3642	72	17	25	25	NUM
iajs-3642	72	18	ml	ml	NOUN
iajs-3642	72	19	ethanol	ethanol	NOUN
iajs-3642	72	20	and	and	CCONJ
iajs-3642	72	21	the	the	DET
iajs-3642	72	22	addition	addition	NOUN
iajs-3642	72	23	of	of	ADP
iajs-3642	72	24	a	a	DET
iajs-3642	72	25	few	few	ADJ
iajs-3642	72	26	drops	drop	NOUN
iajs-3642	72	27	of	of	ADP
iajs-3642	72	28	gaa	gaa	PRON
iajs-3642	72	29	under	under	ADP
iajs-3642	72	30	reflux	reflux	NOUN
iajs-3642	72	31	conditions	condition	NOUN
iajs-3642	72	32	for	for	ADP
iajs-3642	72	33	(	(	PUNCT
iajs-3642	72	34	30	30	NUM
iajs-3642	72	35	min	min	NOUN
iajs-3642	72	36	)	)	PUNCT
iajs-3642	72	37	led	lead	VERB
iajs-3642	72	38	to	to	ADP
iajs-3642	72	39	the	the	DET
iajs-3642	72	40	formation	formation	NOUN
iajs-3642	72	41	of	of	ADP
iajs-3642	72	42	a	a	DET
iajs-3642	72	43	white	white	ADJ
iajs-3642	72	44	precipitate	precipitate	NOUN
iajs-3642	72	45	with	with	ADP
iajs-3642	72	46	a	a	DET
iajs-3642	72	47	good	good	ADJ
iajs-3642	72	48	yield	yield	NOUN
iajs-3642	72	49	.	.	PUNCT
iajs-3642	73	1	the	the	DET
iajs-3642	73	2	release	release	NOUN
iajs-3642	73	3	of	of	ADP
iajs-3642	73	4	a	a	DET
iajs-3642	73	5	gas	gas	NOUN
iajs-3642	73	6	that	that	PRON
iajs-3642	73	7	changes	change	VERB
iajs-3642	73	8	the	the	DET
iajs-3642	73	9	color	color	NOUN
iajs-3642	73	10	of	of	ADP
iajs-3642	73	11	the	the	DET
iajs-3642	73	12	blue	blue	ADJ
iajs-3642	73	13	litmus	litmus	PROPN
iajs-3642	73	14	paper	paper	NOUN
iajs-3642	73	15	to	to	ADP
iajs-3642	73	16	red	red	PROPN
iajs-3642	73	17	was	be	AUX
iajs-3642	73	18	noticed	notice	VERB
iajs-3642	73	19	,	,	PUNCT
iajs-3642	73	20	a	a	DET
iajs-3642	73	21	checked	check	VERB
iajs-3642	73	22	completion	completion	NOUN
iajs-3642	73	23	reaction	reaction	NOUN
iajs-3642	73	24	by	by	ADP
iajs-3642	73	25	tlc	tlc	PROPN
iajs-3642	73	26	.	.	PUNCT
iajs-3642	74	1	the	the	DET
iajs-3642	74	2	fine	fine	ADJ
iajs-3642	74	3	white	white	ADJ
iajs-3642	74	4	powder	powder	NOUN
iajs-3642	74	5	was	be	AUX
iajs-3642	74	6	obtained	obtain	VERB
iajs-3642	74	7	after	after	ADP
iajs-3642	74	8	being	be	AUX
iajs-3642	74	9	filtered	filter	VERB
iajs-3642	74	10	,	,	PUNCT
iajs-3642	74	11	dried	dry	VERB
iajs-3642	74	12	,	,	PUNCT
iajs-3642	74	13	and	and	CCONJ
iajs-3642	74	14	recrystallized	recrystallize	VERB
iajs-3642	74	15	with	with	ADP
iajs-3642	74	16	n	n	NOUN
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iajs-3642	74	19	.	.	PUNCT
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iajs-3642	75	2	1	1	NUM
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iajs-3642	75	4	the	the	DET
iajs-3642	75	5	physical	physical	ADJ
iajs-3642	75	6	properties	property	NOUN
iajs-3642	75	7	.	.	PUNCT
iajs-3642	76	1	2.5.1	2.5.1	NUM
iajs-3642	76	2	.	.	PUNCT
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iajs-3642	77	2	'	'	NUM
iajs-3642	78	1	,	,	PUNCT
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iajs-3642	78	3	(	(	PUNCT
iajs-3642	78	4	3a	3a	NUM
iajs-3642	78	5	)	)	PUNCT
iajs-3642	78	6	the	the	DET
iajs-3642	78	7	ft	ft	PROPN
iajs-3642	78	8	-	-	PUNCT
iajs-3642	78	9	ir	ir	PROPN
iajs-3642	78	10	(	(	PUNCT
iajs-3642	78	11	υ	υ	PROPN
iajs-3642	78	12	,	,	PUNCT
iajs-3642	78	13	cm-1	cm-1	NOUN
iajs-3642	78	14	):	):	PUNCT
iajs-3642	78	15	3206	3206	NUM
iajs-3642	78	16	(	(	PUNCT
iajs-3642	78	17	n	n	CCONJ
iajs-3642	78	18	-	-	PUNCT
iajs-3642	78	19	h	h	NOUN
iajs-3642	78	20	)	)	PUNCT
iajs-3642	78	21	,	,	PUNCT
iajs-3642	78	22	3065	3065	NUM
iajs-3642	78	23	(	(	PUNCT
iajs-3642	78	24	c	c	NOUN
iajs-3642	78	25	-	-	PUNCT
iajs-3642	78	26	harom	harom	NOUN
iajs-3642	78	27	.	.	PUNCT
iajs-3642	78	28	)	)	PUNCT
iajs-3642	78	29	,	,	PUNCT
iajs-3642	78	30	2971	2971	NUM
iajs-3642	78	31	,	,	PUNCT
iajs-3642	78	32	2	2	NUM
iajs-3642	78	33	927(c	927(c	NOUN
iajs-3642	78	34	-	-	PUNCT
iajs-3642	78	35	haliph	haliph	NOUN
iajs-3642	78	36	.	.	PUNCT
iajs-3642	78	37	)	)	PUNCT
iajs-3642	78	38	,	,	PUNCT
iajs-3642	78	39	1688	1688	NUM
iajs-3642	78	40	(	(	PUNCT
iajs-3642	78	41	nhc	nhc	NOUN
iajs-3642	78	42	=	=	PUNCT
iajs-3642	78	43	oamide	oamide	ADV
iajs-3642	78	44	)	)	PUNCT
iajs-3642	78	45	,	,	PUNCT
iajs-3642	78	46	1583	1583	NUM
iajs-3642	78	47	,	,	PUNCT
iajs-3642	78	48	15	15	NUM
iajs-3642	78	49	12(c	12(c	NUM
iajs-3642	78	50	=	=	SYM
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iajs-3642	78	52	,	,	PUNCT
iajs-3642	78	53	11	11	NUM
iajs-3642	78	54	62(so2	62(so2	NOUN
iajs-3642	78	55	)	)	PUNCT
iajs-3642	78	56	.	.	PUNCT
iajs-3642	79	1	2.5.2	2.5.2	NUM
iajs-3642	79	2	.	.	NUM
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iajs-3642	79	4	'	'	CCONJ
iajs-3642	79	5	,	,	PUNCT
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iajs-3642	79	7	(	(	PUNCT
iajs-3642	79	8	4	4	NUM
iajs-3642	79	9	-	-	PUNCT
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iajs-3642	79	11	)	)	PUNCT
iajs-3642	79	12	(	(	PUNCT
iajs-3642	79	13	3b	3b	NUM
iajs-3642	79	14	)	)	PUNCT
iajs-3642	79	15	the	the	DET
iajs-3642	79	16	ft	ft	PROPN
iajs-3642	79	17	-	-	PUNCT
iajs-3642	79	18	ir	ir	PROPN
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iajs-3642	79	20	υ	υ	PROPN
iajs-3642	79	21	,	,	PUNCT
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iajs-3642	79	23	):	):	PUNCT
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iajs-3642	79	25	(	(	PUNCT
iajs-3642	79	26	n	n	CCONJ
iajs-3642	79	27	-	-	PUNCT
iajs-3642	79	28	h	h	NOUN
iajs-3642	79	29	)	)	PUNCT
iajs-3642	79	30	,	,	PUNCT
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iajs-3642	79	32	(	(	PUNCT
iajs-3642	79	33	c	c	NOUN
iajs-3642	79	34	-	-	PUNCT
iajs-3642	79	35	harom	harom	NOUN
iajs-3642	79	36	.	.	PUNCT
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iajs-3642	79	38	,	,	PUNCT
iajs-3642	79	39	2996	2996	NUM
iajs-3642	79	40	,	,	PUNCT
iajs-3642	79	41	2931	2931	NUM
iajs-3642	79	42	(	(	PUNCT
iajs-3642	79	43	c	c	NOUN
iajs-3642	79	44	-	-	PUNCT
iajs-3642	79	45	haliph	haliph	NOUN
iajs-3642	79	46	.	.	PUNCT
iajs-3642	79	47	)	)	PUNCT
iajs-3642	79	48	,	,	PUNCT
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iajs-3642	79	50	(	(	PUNCT
iajs-3642	79	51	nhc	nhc	NOUN
iajs-3642	79	52	=	=	PUNCT
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iajs-3642	79	54	)	)	PUNCT
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iajs-3642	79	56	,	,	PUNCT
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iajs-3642	79	60	=	=	SYM
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iajs-3642	79	72	1h	1h	NUM
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iajs-3642	79	74	(	(	PUNCT
iajs-3642	79	75	h	h	PROPN
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iajs-3642	79	78	):	):	PUNCT
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iajs-3642	79	81	2h	2h	NUM
iajs-3642	79	82	,	,	PUNCT
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iajs-3642	79	84	,	,	PUNCT
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iajs-3642	79	88	,	,	PUNCT
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iajs-3642	79	90	,	,	PUNCT
iajs-3642	79	91	nh	nh	PROPN
iajs-3642	79	92	-	-	PUNCT
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iajs-3642	79	98	,	,	PUNCT
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iajs-3642	79	112	ch2	ch2	PROPN
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iajs-3642	79	119	,	,	PUNCT
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iajs-3642	79	122	nhc	nhc	PROPN
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iajs-3642	79	126	,	,	PUNCT
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iajs-3642	81	9	.	.	PUNCT
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iajs-3642	81	45	,	,	PUNCT
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iajs-3642	81	47	,	,	PUNCT
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iajs-3642	81	49	(	(	PUNCT
iajs-3642	81	50	c	c	NOUN
iajs-3642	81	51	-	-	PUNCT
iajs-3642	81	52	haliph	haliph	NOUN
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iajs-3642	81	55	,	,	PUNCT
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iajs-3642	81	57	(	(	PUNCT
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iajs-3642	81	62	,	,	PUNCT
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iajs-3642	81	64	,	,	PUNCT
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iajs-3642	81	80	(	(	PUNCT
iajs-3642	81	81	h	h	PROPN
iajs-3642	81	82	,	,	PUNCT
iajs-3642	81	83	ppm	ppm	NUM
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iajs-3642	81	86	(	(	PUNCT
iajs-3642	81	87	2h	2h	NUM
iajs-3642	81	88	,	,	PUNCT
iajs-3642	81	89	s	s	X
iajs-3642	81	90	,	,	PUNCT
iajs-3642	81	91	nhso2	nhso2	NOUN
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iajs-3642	81	93	,	,	PUNCT
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iajs-3642	81	95	(	(	PUNCT
iajs-3642	81	96	2h	2h	NUM
iajs-3642	81	97	,	,	PUNCT
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iajs-3642	81	99	,	,	PUNCT
iajs-3642	81	100	nh	nh	PROPN
iajs-3642	81	101	-	-	PUNCT
iajs-3642	81	102	c	c	NOUN
iajs-3642	81	103	=	=	SYM
iajs-3642	81	104	o),7.50–7.11(8h	o),7.50–7.11(8h	NUM
iajs-3642	81	105	,	,	PUNCT
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iajs-3642	81	107	,	,	PUNCT
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iajs-3642	81	112	,	,	PUNCT
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iajs-3642	81	119	ch2	ch2	PROPN
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iajs-3642	81	121	;	;	PUNCT
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iajs-3642	81	124	(	(	PUNCT
iajs-3642	81	125	c	c	NOUN
iajs-3642	81	126	,	,	PUNCT
iajs-3642	81	127	ppm	ppm	NOUN
iajs-3642	81	128	):	):	PUNCT
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iajs-3642	81	130	(	(	PUNCT
iajs-3642	81	131	nhc	nhc	NOUN
iajs-3642	81	132	=	=	PUNCT
iajs-3642	81	133	oamide	oamide	ADV
iajs-3642	81	134	)	)	PUNCT
iajs-3642	81	135	,	,	PUNCT
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iajs-3642	81	141	-	-	NOUN
iajs-3642	81	142	c	c	NOUN
iajs-3642	81	143	)	)	PUNCT
iajs-3642	81	144	,	,	PUNCT
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iajs-3642	81	146	(	(	PUNCT
iajs-3642	81	147	ch2	ch2	PROPN
iajs-3642	81	148	-	-	PUNCT
iajs-3642	81	149	ch2	ch2	NOUN
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iajs-3642	81	152	(	(	PUNCT
iajs-3642	81	153	ch3	ch3	PROPN
iajs-3642	81	154	)	)	PUNCT
iajs-3642	81	155	.	.	PUNCT
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iajs-3642	82	2	.	.	PUNCT
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iajs-3642	82	4	of	of	ADP
iajs-3642	82	5	dibenzyl	dibenzyl	NOUN
iajs-3642	82	6	succinohydrazide	succinohydrazide	PROPN
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iajs-3642	82	8	-	-	PUNCT
iajs-3642	82	9	c	c	NOUN
iajs-3642	82	10	)	)	PUNCT
iajs-3642	83	1	[	[	X
iajs-3642	83	2	27	27	NUM
iajs-3642	83	3	]	]	PUNCT
iajs-3642	83	4	with	with	ADP
iajs-3642	83	5	modification	modification	NOUN
iajs-3642	83	6	in	in	ADP
iajs-3642	83	7	a	a	DET
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iajs-3642	83	9	-	-	PUNCT
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iajs-3642	83	11	flask	flask	NOUN
iajs-3642	83	12	,	,	PUNCT
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iajs-3642	83	14	mixture	mixture	NOUN
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iajs-3642	83	16	compound	compound	NOUN
iajs-3642	83	17	(	(	PUNCT
iajs-3642	83	18	1	1	NUM
iajs-3642	83	19	)	)	PUNCT
iajs-3642	83	20	(	(	PUNCT
iajs-3642	83	21	0.6	0.6	NUM
iajs-3642	83	22	g	g	NOUN
iajs-3642	83	23	,	,	PUNCT
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iajs-3642	83	25	mmol	mmol	NOUN
iajs-3642	83	26	)	)	PUNCT
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iajs-3642	83	28	added	add	VERB
iajs-3642	83	29	to	to	ADP
iajs-3642	83	30	10	10	NUM
iajs-3642	83	31	ml	ml	NOUN
iajs-3642	83	32	dmf	dmf	PROPN
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iajs-3642	83	35	,	,	PUNCT
iajs-3642	83	36	and	and	CCONJ
iajs-3642	83	37	(	(	PUNCT
iajs-3642	83	38	1.11	1.11	NUM
iajs-3642	83	39	ml	ml	NOUN
iajs-3642	83	40	,	,	PUNCT
iajs-3642	83	41	8	8	NUM
iajs-3642	83	42	mmol	mmol	NOUN
iajs-3642	83	43	)	)	PUNCT
iajs-3642	83	44	from	from	ADP
iajs-3642	83	45	et3n	et3n	PROPN
iajs-3642	83	46	was	be	AUX
iajs-3642	83	47	added	add	VERB
iajs-3642	83	48	as	as	ADP
iajs-3642	83	49	a	a	DET
iajs-3642	83	50	catalyst	catalyst	NOUN
iajs-3642	83	51	;	;	PUNCT
iajs-3642	83	52	(	(	PUNCT
iajs-3642	83	53	8	8	NUM
iajs-3642	83	54	mmol	mmol	NOUN
iajs-3642	83	55	)	)	PUNCT
iajs-3642	83	56	of	of	ADP
iajs-3642	83	57	benzyl	benzyl	NOUN
iajs-3642	83	58	chloride	chloride	NOUN
iajs-3642	83	59	with	with	ADP
iajs-3642	83	60	a	a	DET
iajs-3642	83	61	different	different	ADJ
iajs-3642	83	62	substituent	substituent	NOUN
iajs-3642	83	63	in	in	ADP
iajs-3642	83	64	dmf	dmf	PROPN
iajs-3642	83	65	(	(	PUNCT
iajs-3642	83	66	10	10	NUM
iajs-3642	83	67	ml	ml	NOUN
iajs-3642	83	68	)	)	PUNCT
iajs-3642	83	69	was	be	AUX
iajs-3642	83	70	added	add	VERB
iajs-3642	83	71	.	.	PUNCT
iajs-3642	84	1	after	after	ADP
iajs-3642	84	2	15	15	NUM
iajs-3642	84	3	-	-	SYM
iajs-3642	84	4	25	25	NUM
iajs-3642	84	5	hours	hour	NOUN
iajs-3642	84	6	of	of	ADP
iajs-3642	84	7	reflux	reflux	NOUN
iajs-3642	84	8	,	,	PUNCT
iajs-3642	84	9	the	the	DET
iajs-3642	84	10	mixture	mixture	NOUN
iajs-3642	84	11	was	be	AUX
iajs-3642	84	12	poured	pour	VERB
iajs-3642	84	13	over	over	ADP
iajs-3642	84	14	grinding	grind	VERB
iajs-3642	84	15	ice	ice	NOUN
iajs-3642	84	16	and	and	CCONJ
iajs-3642	84	17	extracted	extract	VERB
iajs-3642	84	18	with	with	ADP
iajs-3642	84	19	diethyl	diethyl	NOUN
iajs-3642	84	20	ether	ether	NOUN
iajs-3642	84	21	.	.	PUNCT
iajs-3642	85	1	the	the	DET
iajs-3642	85	2	physical	physical	ADJ
iajs-3642	85	3	characteristics	characteristic	NOUN
iajs-3642	85	4	are	be	AUX
iajs-3642	85	5	detailed	detail	VERB
iajs-3642	85	6	in	in	ADP
iajs-3642	85	7	table	table	NOUN
iajs-3642	85	8	1	1	NUM
iajs-3642	85	9	.	.	PUNCT
iajs-3642	86	1	2.6.1	2.6.1	NUM
iajs-3642	86	2	.	.	PUNCT
iajs-3642	87	1	n'1	n'1	PROPN
iajs-3642	87	2	,	,	PUNCT
iajs-3642	87	3	n'4	n'4	PROPN
iajs-3642	87	4	-	-	PUNCT
iajs-3642	87	5	dibenzylsuccinohydrazide	dibenzylsuccinohydrazide	NOUN
iajs-3642	87	6	(	(	PUNCT
iajs-3642	87	7	4a	4a	NUM
iajs-3642	87	8	)	)	PUNCT
iajs-3642	87	9	the	the	DET
iajs-3642	87	10	ft	ft	PROPN
iajs-3642	87	11	-	-	PUNCT
iajs-3642	87	12	ir	ir	PROPN
iajs-3642	87	13	(	(	PUNCT
iajs-3642	87	14	υ	υ	PROPN
iajs-3642	87	15	,	,	PUNCT
iajs-3642	87	16	cm-1	cm-1	NUM
iajs-3642	87	17	):	):	PUNCT
iajs-3642	87	18	3400	3400	NUM
iajs-3642	87	19	(	(	PUNCT
iajs-3642	87	20	n	n	CCONJ
iajs-3642	87	21	-	-	PUNCT
iajs-3642	87	22	h	h	NOUN
iajs-3642	87	23	)	)	PUNCT
iajs-3642	87	24	,	,	PUNCT
iajs-3642	87	25	3033	3033	NUM
iajs-3642	87	26	(	(	PUNCT
iajs-3642	87	27	c	c	NOUN
iajs-3642	87	28	-	-	PUNCT
iajs-3642	87	29	harom	harom	NOUN
iajs-3642	87	30	.	.	PUNCT
iajs-3642	87	31	)	)	PUNCT
iajs-3642	87	32	,	,	PUNCT
iajs-3642	87	33	2978	2978	NUM
iajs-3642	87	34	,	,	PUNCT
iajs-3642	87	35	2882	2882	NUM
iajs-3642	87	36	(	(	PUNCT
iajs-3642	87	37	c	c	NOUN
iajs-3642	87	38	-	-	PUNCT
iajs-3642	87	39	haliph	haliph	NOUN
iajs-3642	87	40	.	.	PUNCT
iajs-3642	87	41	)	)	PUNCT
iajs-3642	87	42	,	,	PUNCT
iajs-3642	87	43	1664	1664	NUM
iajs-3642	87	44	(	(	PUNCT
iajs-3642	87	45	nhc	nhc	NOUN
iajs-3642	87	46	=	=	PUNCT
iajs-3642	87	47	oamide	oamide	ADV
iajs-3642	87	48	)	)	PUNCT
iajs-3642	87	49	,	,	PUNCT
iajs-3642	87	50	1639	1639	NUM
iajs-3642	87	51	,	,	PUNCT
iajs-3642	87	52	1540	1540	NUM
iajs-3642	87	53	(	(	PUNCT
iajs-3642	87	54	c	c	NOUN
iajs-3642	87	55	=	=	NOUN
iajs-3642	87	56	carom	carom	NOUN
iajs-3642	87	57	.	.	PUNCT
iajs-3642	87	58	)	)	PUNCT
iajs-3642	87	59	.	.	PUNCT
iajs-3642	88	1	2.6.2	2.6.2	X
iajs-3642	88	2	.	.	PUNCT
iajs-3642	88	3	n'1	n'1	PROPN
iajs-3642	88	4	,	,	PUNCT
iajs-3642	88	5	n'4	n'4	PROPN
iajs-3642	88	6	-	-	PUNCT
iajs-3642	88	7	bis	bis	X
iajs-3642	88	8	(	(	PUNCT
iajs-3642	88	9	2	2	NUM
iajs-3642	88	10	-	-	PUNCT
iajs-3642	88	11	nitrobenzyl	nitrobenzyl	NOUN
iajs-3642	88	12	)	)	PUNCT
iajs-3642	88	13	succinohydrazide	succinohydrazide	NOUN
iajs-3642	88	14	(	(	PUNCT
iajs-3642	88	15	4b	4b	PROPN
iajs-3642	88	16	)	)	PUNCT
iajs-3642	88	17	the	the	DET
iajs-3642	88	18	ft	ft	PROPN
iajs-3642	88	19	-	-	PUNCT
iajs-3642	88	20	ir	ir	PROPN
iajs-3642	88	21	(	(	PUNCT
iajs-3642	88	22	υ	υ	PROPN
iajs-3642	88	23	,	,	PUNCT
iajs-3642	88	24	cm-1	cm-1	NOUN
iajs-3642	88	25	):	):	PUNCT
iajs-3642	88	26	3391	3391	NUM
iajs-3642	88	27	(	(	PUNCT
iajs-3642	88	28	n	n	CCONJ
iajs-3642	88	29	-	-	PUNCT
iajs-3642	88	30	h	h	NOUN
iajs-3642	88	31	)	)	PUNCT
iajs-3642	88	32	,	,	PUNCT
iajs-3642	88	33	3088	3088	NUM
iajs-3642	88	34	(	(	PUNCT
iajs-3642	88	35	c	c	NOUN
iajs-3642	88	36	-	-	PUNCT
iajs-3642	88	37	harom	harom	NOUN
iajs-3642	88	38	.	.	PUNCT
iajs-3642	88	39	)	)	PUNCT
iajs-3642	88	40	,	,	PUNCT
iajs-3642	88	41	2946	2946	NUM
iajs-3642	88	42	,	,	PUNCT
iajs-3642	88	43	2880	2880	NUM
iajs-3642	88	44	(	(	PUNCT
iajs-3642	88	45	c	c	NOUN
iajs-3642	88	46	-	-	PUNCT
iajs-3642	88	47	haliph	haliph	NOUN
iajs-3642	88	48	.	.	PUNCT
iajs-3642	88	49	)	)	PUNCT
iajs-3642	88	50	,	,	PUNCT
iajs-3642	88	51	1668	1668	NUM
iajs-3642	88	52	(	(	PUNCT
iajs-3642	88	53	nhc	nhc	NOUN
iajs-3642	88	54	=	=	PUNCT
iajs-3642	88	55	oamide	oamide	ADV
iajs-3642	88	56	)	)	PUNCT
iajs-3642	88	57	,	,	PUNCT
iajs-3642	88	58	1623,160	1623,160	NUM
iajs-3642	88	59	(	(	PUNCT
iajs-3642	88	60	c	c	NOUN
iajs-3642	88	61	=	=	SYM
iajs-3642	88	62	carom.)1521	carom.)1521	NOUN
iajs-3642	88	63	,	,	PUNCT
iajs-3642	88	64	1319	1319	NUM
iajs-3642	88	65	(	(	PUNCT
iajs-3642	88	66	no2)1130	no2)1130	PROPN
iajs-3642	88	67	,	,	PUNCT
iajs-3642	88	68	743	743	NUM
iajs-3642	88	69	(	(	PUNCT
iajs-3642	88	70	o	o	NOUN
iajs-3642	88	71	-	-	NOUN
iajs-3642	88	72	sub	sub	NOUN
iajs-3642	88	73	)	)	PUNCT
iajs-3642	88	74	.	.	PUNCT
iajs-3642	89	1	2.6.3	2.6.3	NUM
iajs-3642	89	2	.	.	PUNCT
iajs-3642	89	3	n'1	n'1	PROPN
iajs-3642	89	4	,	,	PUNCT
iajs-3642	89	5	n'4	n'4	PROPN
iajs-3642	89	6	-	-	PUNCT
iajs-3642	89	7	bis	bis	X
iajs-3642	89	8	(	(	PUNCT
iajs-3642	89	9	4	4	NUM
iajs-3642	89	10	-	-	PUNCT
iajs-3642	89	11	nitrobenzyl	nitrobenzyl	NOUN
iajs-3642	89	12	)	)	PUNCT
iajs-3642	89	13	succinohydrazide	succinohydrazide	NOUN
iajs-3642	89	14	(	(	PUNCT
iajs-3642	89	15	4c	4c	NOUN
iajs-3642	89	16	)	)	PUNCT
iajs-3642	89	17	the	the	DET
iajs-3642	89	18	ft	ft	PROPN
iajs-3642	89	19	-	-	PUNCT
iajs-3642	89	20	ir	ir	PROPN
iajs-3642	89	21	(	(	PUNCT
iajs-3642	89	22	υ	υ	PROPN
iajs-3642	89	23	,	,	PUNCT
iajs-3642	89	24	cm-1	cm-1	NUM
iajs-3642	89	25	):	):	PUNCT
iajs-3642	89	26	3214	3214	NUM
iajs-3642	89	27	(	(	PUNCT
iajs-3642	89	28	n	n	CCONJ
iajs-3642	89	29	-	-	PUNCT
iajs-3642	89	30	h	h	NOUN
iajs-3642	89	31	)	)	PUNCT
iajs-3642	89	32	,	,	PUNCT
iajs-3642	89	33	3073	3073	NUM
iajs-3642	89	34	(	(	PUNCT
iajs-3642	89	35	c	c	NOUN
iajs-3642	89	36	-	-	PUNCT
iajs-3642	89	37	harom	harom	NOUN
iajs-3642	89	38	.	.	PUNCT
iajs-3642	89	39	)	)	PUNCT
iajs-3642	89	40	,	,	PUNCT
iajs-3642	89	41	2968	2968	NUM
iajs-3642	89	42	,	,	PUNCT
iajs-3642	89	43	2887	2887	NUM
iajs-3642	89	44	(	(	PUNCT
iajs-3642	89	45	c	c	NOUN
iajs-3642	89	46	-	-	PUNCT
iajs-3642	89	47	haliph	haliph	NOUN
iajs-3642	89	48	.	.	PUNCT
iajs-3642	89	49	)	)	PUNCT
iajs-3642	89	50	,	,	PUNCT
iajs-3642	89	51	1668	1668	NUM
iajs-3642	89	52	(	(	PUNCT
iajs-3642	89	53	nhc	nhc	NOUN
iajs-3642	89	54	=	=	PUNCT
iajs-3642	89	55	oamide	oamide	ADV
iajs-3642	89	56	)	)	PUNCT
iajs-3642	89	57	,	,	PUNCT
iajs-3642	89	58	1655	1655	NUM
iajs-3642	89	59	,	,	PUNCT
iajs-3642	89	60	1598	1598	NUM
iajs-3642	89	61	(	(	PUNCT
iajs-3642	89	62	c	c	X
iajs-3642	89	63	=	=	X
iajs-3642	89	64	carom.)1510,1339	carom.)1510,1339	X
iajs-3642	89	65	(	(	PUNCT
iajs-3642	89	66	no2	no2	NOUN
iajs-3642	89	67	)	)	PUNCT
iajs-3642	89	68	1106,850	1106,850	NUM
iajs-3642	89	69	(	(	PUNCT
iajs-3642	89	70	p	p	NOUN
iajs-3642	89	71	-	-	PUNCT
iajs-3642	89	72	sub	sub	NOUN
iajs-3642	89	73	)	)	PUNCT
iajs-3642	89	74	;	;	PUNCT
iajs-3642	89	75	1h	1h	NUM
iajs-3642	89	76	nmr	nmr	NOUN
iajs-3642	89	77	(	(	PUNCT
iajs-3642	89	78	h	h	PROPN
iajs-3642	89	79	,	,	PUNCT
iajs-3642	89	80	ppm	ppm	NUM
iajs-3642	89	81	):	):	PUNCT
iajs-3642	89	82	9.01	9.01	NUM
iajs-3642	89	83	(	(	PUNCT
iajs-3642	89	84	2h	2h	NUM
iajs-3642	89	85	,	,	PUNCT
iajs-3642	89	86	s	s	X
iajs-3642	89	87	,	,	PUNCT
iajs-3642	89	88	nhc	nhc	PROPN
iajs-3642	89	89	=	=	PROPN
iajs-3642	89	90	o	o	NOUN
iajs-3642	89	91	)	)	PUNCT
iajs-3642	89	92	,	,	PUNCT
iajs-3642	89	93	5.35	5.35	NUM
iajs-3642	89	94	(	(	PUNCT
iajs-3642	89	95	2h	2h	NUM
iajs-3642	89	96	,	,	PUNCT
iajs-3642	89	97	s	s	X
iajs-3642	89	98	,	,	PUNCT
iajs-3642	89	99	nhch2	nhch2	NOUN
iajs-3642	89	100	)	)	PUNCT
iajs-3642	89	101	,	,	PUNCT
iajs-3642	89	102	8.15–7.63	8.15–7.63	NUM
iajs-3642	89	103	(	(	PUNCT
iajs-3642	89	104	8h	8h	NUM
iajs-3642	89	105	,	,	PUNCT
iajs-3642	89	106	q	q	NOUN
iajs-3642	89	107	,	,	PUNCT
iajs-3642	89	108	ar	ar	NOUN
iajs-3642	89	109	-	-	NOUN
iajs-3642	89	110	h	h	NOUN
iajs-3642	89	111	)	)	PUNCT
iajs-3642	89	112	,	,	PUNCT
iajs-3642	89	113	4.13	4.13	NUM
iajs-3642	89	114	(	(	PUNCT
iajs-3642	89	115	phch2	phch2	PROPN
iajs-3642	89	116	)	)	PUNCT
iajs-3642	89	117	,	,	PUNCT
iajs-3642	89	118	2.74	2.74	NUM
iajs-3642	89	119	-	-	SYM
iajs-3642	89	120	2.71	2.71	NUM
iajs-3642	89	121	(	(	PUNCT
iajs-3642	89	122	4h	4h	NUM
iajs-3642	89	123	,	,	PUNCT
iajs-3642	89	124	t	t	PROPN
iajs-3642	89	125	,	,	PUNCT
iajs-3642	89	126	ch2	ch2	PROPN
iajs-3642	89	127	)	)	PUNCT
iajs-3642	89	128	;	;	PUNCT
iajs-3642	89	129	13c	13c	X
iajs-3642	89	130	nmr	nmr	NOUN
iajs-3642	89	131	(	(	PUNCT
iajs-3642	89	132	c	c	NOUN
iajs-3642	89	133	,	,	PUNCT
iajs-3642	89	134	ppm	ppm	NOUN
iajs-3642	89	135	):	):	PUNCT
iajs-3642	89	136	170.99	170.99	NUM
iajs-3642	89	137	(	(	PUNCT
iajs-3642	89	138	c	c	NOUN
iajs-3642	89	139	=	=	NOUN
iajs-3642	89	140	oamide	oamide	ADJ
iajs-3642	89	141	)	)	PUNCT
iajs-3642	89	142	,	,	PUNCT
iajs-3642	89	143	146.39	146.39	NUM
iajs-3642	89	144	-	-	SYM
iajs-3642	89	145	123.63	123.63	NUM
iajs-3642	89	146	(	(	PUNCT
iajs-3642	89	147	ar	ar	NOUN
iajs-3642	89	148	-	-	NOUN
iajs-3642	89	149	c	c	NOUN
iajs-3642	89	150	)	)	PUNCT
iajs-3642	89	151	,	,	PUNCT
iajs-3642	89	152	54.18	54.18	NUM
iajs-3642	89	153	(	(	PUNCT
iajs-3642	89	154	phch2	phch2	PROPN
iajs-3642	89	155	)	)	PUNCT
iajs-3642	89	156	,	,	PUNCT
iajs-3642	89	157	29.20(ch2	29.20(ch2	NUM
iajs-3642	89	158	-	-	PUNCT
iajs-3642	89	159	ch2	ch2	NOUN
iajs-3642	89	160	)	)	PUNCT
iajs-3642	89	161	.	.	PUNCT
iajs-3642	90	1	2.7	2.7	NUM
iajs-3642	90	2	.	.	PUNCT
iajs-3642	90	3	synthesis	synthesis	NOUN
iajs-3642	90	4	of	of	ADP
iajs-3642	90	5	n'1,n'4	n'1,n'4	NUM
iajs-3642	90	6	-	-	PUNCT
iajs-3642	90	7	bis(2	bis(2	NOUN
iajs-3642	90	8	-	-	PUNCT
iajs-3642	90	9	oxo-2	oxo-2	ADV
iajs-3642	90	10	-	-	PUNCT
iajs-3642	90	11	phenylethyl	phenylethyl	NOUN
iajs-3642	90	12	)	)	PUNCT
iajs-3642	90	13	succinohydrazide	succinohydrazide	NOUN
iajs-3642	90	14	(	(	PUNCT
iajs-3642	90	15	5	5	NUM
iajs-3642	90	16	)	)	PUNCT
iajs-3642	90	17	(	(	PUNCT
iajs-3642	90	18	28	28	NUM
iajs-3642	90	19	)	)	PUNCT
iajs-3642	90	20	.	.	PUNCT
iajs-3642	91	1	a	a	DET
iajs-3642	91	2	mixture	mixture	NOUN
iajs-3642	91	3	of	of	ADP
iajs-3642	91	4	compound	compound	NOUN
iajs-3642	91	5	(	(	PUNCT
iajs-3642	91	6	1	1	NUM
iajs-3642	91	7	)	)	PUNCT
iajs-3642	91	8	(	(	PUNCT
iajs-3642	91	9	0.3	0.3	NUM
iajs-3642	91	10	g	g	NOUN
iajs-3642	91	11	,	,	PUNCT
iajs-3642	91	12	2	2	NUM
iajs-3642	91	13	mmol	mmol	NOUN
iajs-3642	91	14	)	)	PUNCT
iajs-3642	91	15	and	and	CCONJ
iajs-3642	91	16	phenacyl	phenacyl	VERB
iajs-3642	91	17	chloride	chloride	NOUN
iajs-3642	91	18	(	(	PUNCT
iajs-3642	91	19	0.6	0.6	NUM
iajs-3642	91	20	g	g	NOUN
iajs-3642	91	21	,	,	PUNCT
iajs-3642	91	22	4	4	NUM
iajs-3642	91	23	mmol	mmol	NOUN
iajs-3642	91	24	)	)	PUNCT
iajs-3642	91	25	in	in	ADP
iajs-3642	91	26	15	15	NUM
iajs-3642	91	27	ml	ml	NOUN
iajs-3642	91	28	of	of	ADP
iajs-3642	91	29	dmf	dmf	PROPN
iajs-3642	91	30	in	in	ADP
iajs-3642	91	31	the	the	DET
iajs-3642	91	32	presence	presence	NOUN
iajs-3642	91	33	of	of	ADP
iajs-3642	91	34	et3n	et3n	PROPN
iajs-3642	91	35	(	(	PUNCT
iajs-3642	91	36	0.55	0.55	NUM
iajs-3642	91	37	ml	ml	NOUN
iajs-3642	91	38	,	,	PUNCT
iajs-3642	91	39	4	4	NUM
iajs-3642	91	40	mmol	mmol	NOUN
iajs-3642	91	41	)	)	PUNCT
iajs-3642	91	42	was	be	AUX
iajs-3642	91	43	refluxed	refluxe	VERB
iajs-3642	91	44	for	for	ADP
iajs-3642	91	45	5	5	NUM
iajs-3642	91	46	hours	hour	NOUN
iajs-3642	91	47	(	(	PUNCT
iajs-3642	91	48	according	accord	VERB
iajs-3642	91	49	to	to	ADP
iajs-3642	91	50	tlc	tlc	NOUN
iajs-3642	91	51	results	result	NOUN
iajs-3642	91	52	)	)	PUNCT
iajs-3642	91	53	.	.	PUNCT
iajs-3642	92	1	the	the	DET
iajs-3642	92	2	mixture	mixture	NOUN
iajs-3642	92	3	was	be	AUX
iajs-3642	92	4	put	put	VERB
iajs-3642	92	5	on	on	ADP
iajs-3642	92	6	grinding	grind	VERB
iajs-3642	92	7	ice	ice	NOUN
iajs-3642	92	8	after	after	ADP
iajs-3642	92	9	the	the	DET
iajs-3642	92	10	end	end	NOUN
iajs-3642	92	11	of	of	ADP
iajs-3642	92	12	the	the	DET
iajs-3642	92	13	reaction	reaction	NOUN
iajs-3642	92	14	.	.	PUNCT
iajs-3642	93	1	the	the	DET
iajs-3642	93	2	product	product	NOUN
iajs-3642	93	3	is	be	AUX
iajs-3642	93	4	then	then	ADV
iajs-3642	93	5	extracted	extract	VERB
iajs-3642	93	6	using	use	VERB
iajs-3642	93	7	diethyl	diethyl	NOUN
iajs-3642	93	8	ether	ether	NOUN
iajs-3642	93	9	in	in	ADP
iajs-3642	93	10	a	a	DET
iajs-3642	93	11	separation	separation	NOUN
iajs-3642	93	12	funnel	funnel	NOUN
iajs-3642	93	13	and	and	CCONJ
iajs-3642	93	14	dried	dry	VERB
iajs-3642	93	15	.	.	PUNCT
iajs-3642	94	1	the	the	DET
iajs-3642	94	2	physical	physical	ADJ
iajs-3642	94	3	properties	property	NOUN
iajs-3642	94	4	of	of	ADP
iajs-3642	94	5	the	the	DET
iajs-3642	94	6	compound	compound	NOUN
iajs-3642	94	7	are	be	AUX
iajs-3642	94	8	detailed	detail	VERB
iajs-3642	94	9	in	in	ADP
iajs-3642	94	10	table	table	NOUN
iajs-3642	94	11	1	1	NUM
iajs-3642	94	12	.	.	PUNCT
iajs-3642	94	13	ft	ft	PROPN
iajs-3642	94	14	-	-	PUNCT
iajs-3642	94	15	ir	ir	PROPN
iajs-3642	94	16	(	(	PUNCT
iajs-3642	94	17	υ	υ	PROPN
iajs-3642	94	18	,	,	PUNCT
iajs-3642	94	19	cm-1	cm-1	NOUN
iajs-3642	94	20	):	):	PUNCT
iajs-3642	94	21	3124	3124	NUM
iajs-3642	94	22	(	(	PUNCT
iajs-3642	94	23	n	n	CCONJ
iajs-3642	94	24	-	-	PUNCT
iajs-3642	94	25	h	h	NOUN
iajs-3642	94	26	)	)	PUNCT
iajs-3642	94	27	,	,	PUNCT
iajs-3642	94	28	3059	3059	NUM
iajs-3642	94	29	(	(	PUNCT
iajs-3642	94	30	c	c	NOUN
iajs-3642	94	31	-	-	PUNCT
iajs-3642	94	32	harom	harom	NOUN
iajs-3642	94	33	.	.	PUNCT
iajs-3642	94	34	)	)	PUNCT
iajs-3642	94	35	,	,	PUNCT
iajs-3642	94	36	2980	2980	NUM
iajs-3642	94	37	,	,	PUNCT
iajs-3642	94	38	2878	2878	NUM
iajs-3642	94	39	(	(	PUNCT
iajs-3642	94	40	c	c	NOUN
iajs-3642	94	41	-	-	PUNCT
iajs-3642	94	42	haliph	haliph	NOUN
iajs-3642	94	43	.	.	PUNCT
iajs-3642	94	44	)	)	PUNCT
iajs-3642	95	1	,	,	PUNCT
iajs-3642	95	2	1717	1717	NUM
iajs-3642	95	3	(	(	PUNCT
iajs-3642	95	4	c	c	NOUN
iajs-3642	95	5	=	=	NOUN
iajs-3642	95	6	oketone	oketone	ADJ
iajs-3642	95	7	)	)	PUNCT
iajs-3642	95	8	1686	1686	NUM
iajs-3642	95	9	(	(	PUNCT
iajs-3642	95	10	c	c	NOUN
iajs-3642	95	11	=	=	NOUN
iajs-3642	95	12	oamide	oamide	ADJ
iajs-3642	95	13	)	)	PUNCT
iajs-3642	95	14	,	,	PUNCT
iajs-3642	95	15	1640	1640	NUM
iajs-3642	95	16	,	,	PUNCT
iajs-3642	95	17	1595	1595	NUM
iajs-3642	95	18	(	(	PUNCT
iajs-3642	95	19	c	c	NOUN
iajs-3642	95	20	=	=	NOUN
iajs-3642	95	21	carom	carom	NOUN
iajs-3642	95	22	.	.	PUNCT
iajs-3642	95	23	)	)	PUNCT
iajs-3642	95	24	.	.	PUNCT
iajs-3642	96	1	ihjpas	ihjpas	PROPN
iajs-3642	96	2	.	.	PUNCT
iajs-3642	97	1	2025	2025	NUM
iajs-3642	97	2	,	,	PUNCT
iajs-3642	97	3	38	38	NUM
iajs-3642	97	4	(	(	PUNCT
iajs-3642	97	5	1	1	NUM
iajs-3642	97	6	)	)	PUNCT
iajs-3642	98	1	318	318	NUM
iajs-3642	98	2	scheme1	scheme1	NOUN
iajs-3642	98	3	.	.	PUNCT
iajs-3642	98	4	synthesis	synthesis	NOUN
iajs-3642	98	5	of	of	ADP
iajs-3642	98	6	derivatives	derivative	NOUN
iajs-3642	98	7	(	(	PUNCT
iajs-3642	98	8	1	1	NUM
iajs-3642	98	9	-	-	SYM
iajs-3642	98	10	5	5	NUM
iajs-3642	98	11	)	)	PUNCT
iajs-3642	98	12	.	.	PUNCT
iajs-3642	99	1	table	table	NOUN
iajs-3642	99	2	1	1	NUM
iajs-3642	99	3	.	.	PUNCT
iajs-3642	100	1	chemical	chemical	ADJ
iajs-3642	100	2	formula	formula	NOUN
iajs-3642	100	3	,	,	PUNCT
iajs-3642	100	4	physical	physical	ADJ
iajs-3642	100	5	properties	property	NOUN
iajs-3642	100	6	,	,	PUNCT
iajs-3642	100	7	and	and	CCONJ
iajs-3642	100	8	molecular	molecular	ADJ
iajs-3642	100	9	weight	weight	NOUN
iajs-3642	100	10	of	of	ADP
iajs-3642	100	11	the	the	DET
iajs-3642	100	12	synthesized	synthesize	VERB
iajs-3642	100	13	compounds	compound	NOUN
iajs-3642	100	14	(	(	PUNCT
iajs-3642	100	15	1	1	NUM
iajs-3642	100	16	-	-	SYM
iajs-3642	100	17	5	5	NUM
iajs-3642	100	18	)	)	PUNCT
iajs-3642	100	19	.	.	PUNCT
iajs-3642	101	1	no	no	INTJ
iajs-3642	101	2	.	.	PUNCT
iajs-3642	102	1	chemical	chemical	ADJ
iajs-3642	102	2	structure	structure	NOUN
iajs-3642	102	3	color	color	NOUN
iajs-3642	102	4	melting	melting	NOUN
iajs-3642	102	5	point	point	NOUN
iajs-3642	102	6	(	(	PUNCT
iajs-3642	102	7	℃	℃	PROPN
iajs-3642	102	8	)	)	PUNCT
iajs-3642	102	9	stirring/	stirring/	NUM
iajs-3642	102	10	reflux	reflux	NOUN
iajs-3642	102	11	time	time	NOUN
iajs-3642	102	12	reaction	reaction	NOUN
iajs-3642	102	13	yield	yield	NOUN
iajs-3642	102	14	(	(	PUNCT
iajs-3642	102	15	%	%	INTJ
iajs-3642	102	16	)	)	PUNCT
iajs-3642	103	1	m.wt	m.wt	X
iajs-3642	103	2	(	(	PUNCT
iajs-3642	103	3	g	g	NOUN
iajs-3642	103	4	/	/	SYM
iajs-3642	103	5	mol	mol	NOUN
iajs-3642	103	6	)	)	PUNCT
iajs-3642	103	7	1	1	NUM
iajs-3642	103	8	bright	bright	ADJ
iajs-3642	103	9	white	white	ADJ
iajs-3642	103	10	*	*	PUNCT
iajs-3642	103	11	170	170	NUM
iajs-3642	103	12	-	-	SYM
iajs-3642	103	13	172	172	NUM
iajs-3642	103	14	3	3	NUM
iajs-3642	103	15	hr	hr	NOUN
iajs-3642	103	16	.	.	PUNCT
iajs-3642	104	1	stirring	stir	VERB
iajs-3642	104	2	95	95	NUM
iajs-3642	104	3	146.15	146.15	NUM
iajs-3642	104	4	2a	2a	NUM
iajs-3642	104	5	white	white	ADJ
iajs-3642	104	6	187	187	NUM
iajs-3642	104	7	-	-	SYM
iajs-3642	104	8	190	190	NUM
iajs-3642	104	9	1	1	NUM
iajs-3642	104	10	hr	hr	NOUN
iajs-3642	104	11	.	.	PUNCT
iajs-3642	105	1	stirring	stir	VERB
iajs-3642	105	2	85	85	NUM
iajs-3642	105	3	354.37	354.37	NUM
iajs-3642	105	4	2b	2b	NUM
iajs-3642	105	5	white	white	ADJ
iajs-3642	105	6	210	210	NUM
iajs-3642	105	7	-	-	SYM
iajs-3642	105	8	213	213	NUM
iajs-3642	105	9	0.5	0.5	NUM
iajs-3642	105	10	hr	hr	NOUN
iajs-3642	105	11	.	.	PUNCT
iajs-3642	106	1	stirring	stir	VERB
iajs-3642	106	2	88	88	NUM
iajs-3642	106	3	414.42	414.42	NUM
iajs-3642	106	4	2c	2c	NOUN
iajs-3642	106	5	dark	dark	NOUN
iajs-3642	106	6	off	off	ADP
iajs-3642	106	7	white	white	ADJ
iajs-3642	106	8	183	183	NUM
iajs-3642	106	9	-	-	SYM
iajs-3642	106	10	186	186	NUM
iajs-3642	106	11	9	9	NUM
iajs-3642	106	12	hr	hr	NOUN
iajs-3642	106	13	.	.	PUNCT
iajs-3642	107	1	reflux	reflux	PROPN
iajs-3642	107	2	80	80	NUM
iajs-3642	107	3	423.25	423.25	NUM
iajs-3642	107	4	2d	2d	NOUN
iajs-3642	107	5	dark	dark	ADJ
iajs-3642	107	6	off	off	ADP
iajs-3642	107	7	white	white	PROPN
iajs-3642	107	8	175	175	NUM
iajs-3642	107	9	-	-	SYM
iajs-3642	107	10	178	178	NUM
iajs-3642	107	11	5.25	5.25	NUM
iajs-3642	107	12	h.	h.	NOUN
iajs-3642	107	13	reflux	reflux	NOUN
iajs-3642	107	14	68	68	NUM
iajs-3642	107	15	423.25	423.25	NUM
iajs-3642	107	16	2e	2e	NOUN
iajs-3642	107	17	dark	dark	NOUN
iajs-3642	107	18	off	off	ADP
iajs-3642	107	19	white	white	ADJ
iajs-3642	107	20	180	180	NUM
iajs-3642	107	21	-	-	SYM
iajs-3642	107	22	182	182	NUM
iajs-3642	107	23	4	4	NUM
iajs-3642	107	24	hr	hr	NOUN
iajs-3642	107	25	.	.	PUNCT
iajs-3642	108	1	reflux	reflux	VERB
iajs-3642	108	2	75	75	NUM
iajs-3642	108	3	423.25	423.25	NUM
iajs-3642	108	4	ihjpas	ihjpa	NOUN
iajs-3642	108	5	.	.	PUNCT
iajs-3642	109	1	2025	2025	NUM
iajs-3642	109	2	,	,	PUNCT
iajs-3642	109	3	38	38	NUM
iajs-3642	109	4	(	(	PUNCT
iajs-3642	109	5	1	1	NUM
iajs-3642	109	6	)	)	PUNCT
iajs-3642	109	7	319	319	NUM
iajs-3642	109	8	*	*	PUNCT
iajs-3642	109	9	literature	literature	NOUN
iajs-3642	109	10	(	(	PUNCT
iajs-3642	109	11	169	169	NUM
iajs-3642	109	12	-	-	SYM
iajs-3642	109	13	170	170	NUM
iajs-3642	109	14	)	)	PUNCT
iajs-3642	109	15	℃	℃	PROPN
iajs-3642	109	16	)	)	PUNCT
iajs-3642	109	17	(	(	PUNCT
iajs-3642	109	18	24	24	NUM
iajs-3642	109	19	)	)	PUNCT
iajs-3642	109	20	2.8	2.8	NUM
iajs-3642	109	21	.	.	PUNCT
iajs-3642	109	22	computational	computational	ADJ
iajs-3642	109	23	study	study	NOUN
iajs-3642	109	24	;	;	PUNCT
iajs-3642	109	25	molecular	molecular	ADJ
iajs-3642	109	26	docking	docking	NOUN
iajs-3642	109	27	adme	adme	VERB
iajs-3642	109	28	analysis	analysis	NOUN
iajs-3642	109	29	molecular	molecular	ADJ
iajs-3642	109	30	docking	docking	NOUN
iajs-3642	109	31	determines	determine	VERB
iajs-3642	109	32	the	the	DET
iajs-3642	109	33	optimal	optimal	ADJ
iajs-3642	109	34	orientation	orientation	NOUN
iajs-3642	109	35	of	of	ADP
iajs-3642	109	36	a	a	DET
iajs-3642	109	37	ligand	ligand	NOUN
iajs-3642	109	38	that	that	PRON
iajs-3642	109	39	binds	bind	VERB
iajs-3642	109	40	to	to	ADP
iajs-3642	109	41	a	a	DET
iajs-3642	109	42	protein	protein	NOUN
iajs-3642	109	43	's	's	PART
iajs-3642	109	44	active	active	ADJ
iajs-3642	109	45	site	site	NOUN
iajs-3642	109	46	,	,	PUNCT
iajs-3642	109	47	and	and	CCONJ
iajs-3642	109	48	the	the	DET
iajs-3642	109	49	ligand	ligand	NOUN
iajs-3642	109	50	's	's	PART
iajs-3642	109	51	affinity	affinity	NOUN
iajs-3642	109	52	impacts	impact	VERB
iajs-3642	109	53	its	its	PRON
iajs-3642	109	54	binding	binding	ADJ
iajs-3642	109	55	and	and	CCONJ
iajs-3642	109	56	interaction	interaction	NOUN
iajs-3642	109	57	(	(	PUNCT
iajs-3642	109	58	18	18	NUM
iajs-3642	109	59	)	)	PUNCT
iajs-3642	109	60	.	.	PUNCT
iajs-3642	110	1	the	the	DET
iajs-3642	110	2	protein	protein	NOUN
iajs-3642	110	3	data	data	PROPN
iajs-3642	110	4	bank	bank	PROPN
iajs-3642	110	5	(	(	PUNCT
iajs-3642	110	6	pdb:1sa0	pdb:1sa0	NOUN
iajs-3642	110	7	)	)	PUNCT
iajs-3642	110	8	https://www.rcsb.org	https://www.rcsb.org	PUNCT
iajs-3642	110	9	offered	offer	VERB
iajs-3642	110	10	enzyme	enzyme	NOUN
iajs-3642	110	11	crystal	crystal	NOUN
iajs-3642	110	12	structures	structure	NOUN
iajs-3642	110	13	for	for	ADP
iajs-3642	110	14	docking	docking	NOUN
iajs-3642	110	15	.	.	PUNCT
iajs-3642	111	1	swiss	swiss	ADJ
iajs-3642	111	2	adme	adme	NOUN
iajs-3642	111	3	with	with	ADP
iajs-3642	111	4	boiled	boil	VERB
iajs-3642	111	5	-	-	PUNCT
iajs-3642	111	6	egg	egg	NOUN
iajs-3642	111	7	predicted	predict	VERB
iajs-3642	111	8	the	the	DET
iajs-3642	111	9	synthesized	synthesize	VERB
iajs-3642	111	10	compound	compound	NOUN
iajs-3642	111	11	's	's	PART
iajs-3642	111	12	physicochemical	physicochemical	ADJ
iajs-3642	111	13	characteristics	characteristic	NOUN
iajs-3642	111	14	and	and	CCONJ
iajs-3642	111	15	pharmacokinetics	pharmacokinetic	NOUN
iajs-3642	111	16	,	,	PUNCT
iajs-3642	111	17	which	which	PRON
iajs-3642	111	18	was	be	AUX
iajs-3642	111	19	designed	design	VERB
iajs-3642	111	20	to	to	PART
iajs-3642	111	21	forecast	forecast	VERB
iajs-3642	111	22	the	the	DET
iajs-3642	111	23	tendency	tendency	NOUN
iajs-3642	111	24	of	of	ADP
iajs-3642	111	25	small	small	ADJ
iajs-3642	111	26	compounds	compound	NOUN
iajs-3642	111	27	to	to	PART
iajs-3642	111	28	be	be	AUX
iajs-3642	111	29	absorbed	absorb	VERB
iajs-3642	111	30	by	by	ADP
iajs-3642	111	31	the	the	DET
iajs-3642	111	32	gastrointestinal	gastrointestinal	ADJ
iajs-3642	111	33	system	system	NOUN
iajs-3642	111	34	or	or	CCONJ
iajs-3642	111	35	to	to	PART
iajs-3642	111	36	access	access	VERB
iajs-3642	111	37	the	the	DET
iajs-3642	111	38	brain	brain	NOUN
iajs-3642	111	39	(	(	PUNCT
iajs-3642	111	40	29	29	NUM
iajs-3642	111	41	)	)	PUNCT
iajs-3642	111	42	.	.	PUNCT
iajs-3642	112	1	good	good	ADJ
iajs-3642	112	2	adme	adme	NOUN
iajs-3642	112	3	features	feature	VERB
iajs-3642	112	4	make	make	VERB
iajs-3642	112	5	synthetic	synthetic	ADJ
iajs-3642	112	6	compounds	compound	NOUN
iajs-3642	112	7	drug	drug	NOUN
iajs-3642	112	8	-	-	PUNCT
iajs-3642	112	9	like	like	ADJ
iajs-3642	112	10	(	(	PUNCT
iajs-3642	112	11	30	30	NUM
iajs-3642	112	12	)	)	PUNCT
iajs-3642	112	13	.	.	PUNCT
iajs-3642	113	1	following	follow	VERB
iajs-3642	113	2	lipinski	lipinski	PROPN
iajs-3642	113	3	's	's	PART
iajs-3642	113	4	requirements	requirement	NOUN
iajs-3642	113	5	,	,	PUNCT
iajs-3642	113	6	the	the	DET
iajs-3642	113	7	rule	rule	NOUN
iajs-3642	113	8	created	create	VERB
iajs-3642	113	9	by	by	ADP
iajs-3642	113	10	christopher	christopher	PROPN
iajs-3642	113	11	lipinski	lipinski	PROPN
iajs-3642	113	12	of	of	ADP
iajs-3642	113	13	pfizer	pfizer	NOUN
iajs-3642	113	14	in	in	ADP
iajs-3642	113	15	1997	1997	NUM
iajs-3642	113	16	specifies	specifie	NOUN
iajs-3642	113	17	that	that	PRON
iajs-3642	113	18	an	an	DET
iajs-3642	113	19	orally	orally	ADV
iajs-3642	113	20	active	active	ADJ
iajs-3642	113	21	medicine	medicine	NOUN
iajs-3642	113	22	should	should	AUX
iajs-3642	113	23	have	have	VERB
iajs-3642	113	24	no	no	DET
iajs-3642	113	25	more	more	ADJ
iajs-3642	113	26	than	than	ADP
iajs-3642	113	27	one	one	NUM
iajs-3642	113	28	violation	violation	NOUN
iajs-3642	113	29	of	of	ADP
iajs-3642	113	30	the	the	DET
iajs-3642	113	31	following	follow	VERB
iajs-3642	113	32	conditions	condition	NOUN
iajs-3642	113	33	:	:	PUNCT
iajs-3642	113	34	(	(	PUNCT
iajs-3642	113	35	1	1	X
iajs-3642	113	36	)	)	PUNCT
iajs-3642	113	37	≤	≤	NUM
iajs-3642	113	38	5	5	NUM
iajs-3642	113	39	hydrogen	hydrogen	NOUN
iajs-3642	113	40	bonding	bonding	NOUN
iajs-3642	113	41	donors	donor	NOUN
iajs-3642	113	42	,	,	PUNCT
iajs-3642	113	43	(	(	PUNCT
iajs-3642	113	44	2	2	X
iajs-3642	113	45	)	)	PUNCT
iajs-3642	113	46	hydrogen	hydrogen	NOUN
iajs-3642	113	47	bonding	bonding	NOUN
iajs-3642	113	48	acceptors	acceptor	NOUN
iajs-3642	113	49	≤	≤	NUM
iajs-3642	113	50	10	10	NUM
iajs-3642	113	51	(	(	PUNCT
iajs-3642	113	52	3	3	X
iajs-3642	113	53	)	)	PUNCT
iajs-3642	113	54	molecular	molecular	ADJ
iajs-3642	113	55	weight	weight	NOUN
iajs-3642	113	56	should	should	AUX
iajs-3642	113	57	n't	not	PART
iajs-3642	113	58	go	go	VERB
iajs-3642	113	59	above	above	ADP
iajs-3642	113	60	500	500	NUM
iajs-3642	113	61	m	m	NOUN
iajs-3642	113	62	/	/	SYM
iajs-3642	113	63	z.	z.	PROPN
iajs-3642	113	64	(	(	PUNCT
iajs-3642	113	65	4	4	X
iajs-3642	113	66	)	)	PUNCT
iajs-3642	113	67	the	the	DET
iajs-3642	113	68	lipophilicity	lipophilicity	NOUN
iajs-3642	113	69	(	(	PUNCT
iajs-3642	113	70	clogp	clogp	ADJ
iajs-3642	113	71	)	)	PUNCT
iajs-3642	113	72	≤	≤	NOUN
iajs-3642	113	73	5	5	NUM
iajs-3642	113	74	(	(	PUNCT
iajs-3642	113	75	25	25	NUM
iajs-3642	113	76	)	)	PUNCT
iajs-3642	113	77	.	.	PUNCT
iajs-3642	114	1	oral	oral	ADJ
iajs-3642	114	2	drugs	drug	NOUN
iajs-3642	114	3	have	have	VERB
iajs-3642	114	4	a	a	DET
iajs-3642	114	5	lower	low	ADJ
iajs-3642	114	6	m.wt	m.wt	NOUN
iajs-3642	114	7	.	.	NOUN
iajs-3642	115	1	and	and	CCONJ
iajs-3642	115	2	fewer	few	ADJ
iajs-3642	115	3	h	h	NOUN
iajs-3642	115	4	-	-	PUNCT
iajs-3642	115	5	bond	bond	NOUN
iajs-3642	115	6	donors	donor	NOUN
iajs-3642	115	7	,	,	PUNCT
iajs-3642	115	8	acceptors	acceptor	NOUN
iajs-3642	115	9	,	,	PUNCT
iajs-3642	115	10	and	and	CCONJ
iajs-3642	115	11	rotatable	rotatable	ADJ
iajs-3642	115	12	bonds	bond	NOUN
iajs-3642	115	13	than	than	ADP
iajs-3642	115	14	injectable	injectable	ADJ
iajs-3642	115	15	.	.	PUNCT
iajs-3642	116	1	pulmonary	pulmonary	ADJ
iajs-3642	116	2	medicines	medicine	NOUN
iajs-3642	116	3	have	have	VERB
iajs-3642	116	4	greater	great	ADJ
iajs-3642	116	5	psa	psa	NOUN
iajs-3642	116	6	because	because	SCONJ
iajs-3642	116	7	pulmonary	pulmonary	ADJ
iajs-3642	116	8	permeability	permeability	NOUN
iajs-3642	116	9	is	be	AUX
iajs-3642	116	10	less	less	ADV
iajs-3642	116	11	susceptible	susceptible	ADJ
iajs-3642	116	12	to	to	ADP
iajs-3642	116	13	polar	polar	ADJ
iajs-3642	116	14	hydrogen	hydrogen	NOUN
iajs-3642	116	15	-	-	PUNCT
iajs-3642	116	16	bonding	bonding	NOUN
iajs-3642	116	17	functionality	functionality	NOUN
iajs-3642	116	18	(	(	PUNCT
iajs-3642	116	19	22	22	NUM
iajs-3642	116	20	)	)	PUNCT
iajs-3642	116	21	.	.	PUNCT
iajs-3642	117	1	drug	drug	NOUN
iajs-3642	117	2	properties	property	NOUN
iajs-3642	117	3	like	like	ADP
iajs-3642	117	4	intestinal	intestinal	ADJ
iajs-3642	117	5	absorption	absorption	NOUN
iajs-3642	117	6	and	and	CCONJ
iajs-3642	117	7	brain	brain	NOUN
iajs-3642	117	8	access	access	NOUN
iajs-3642	117	9	help	help	NOUN
iajs-3642	117	10	estimate	estimate	VERB
iajs-3642	117	11	drug	drug	NOUN
iajs-3642	117	12	development	development	NOUN
iajs-3642	117	13	phases	phase	NOUN
iajs-3642	117	14	.	.	PUNCT
iajs-3642	118	1	the	the	DET
iajs-3642	118	2	3a	3a	NUM
iajs-3642	118	3	white	white	VERB
iajs-3642	118	4	166	166	NUM
iajs-3642	118	5	-	-	SYM
iajs-3642	118	6	168	168	NUM
iajs-3642	118	7	0.5	0.5	NUM
iajs-3642	118	8	hr	hr	NOUN
iajs-3642	118	9	.	.	PUNCT
iajs-3642	119	1	stirring	stir	VERB
iajs-3642	119	2	75	75	NUM
iajs-3642	119	3	426.46	426.46	NUM
iajs-3642	119	4	3b	3b	NOUN
iajs-3642	119	5	white	white	NOUN
iajs-3642	119	6	318	318	NUM
iajs-3642	119	7	dec	dec	PROPN
iajs-3642	119	8	.	.	PROPN
iajs-3642	119	9	0.25	0.25	NUM
iajs-3642	119	10	hr	hr	NOUN
iajs-3642	119	11	.	.	PUNCT
iajs-3642	120	1	stirring	stir	VERB
iajs-3642	120	2	70	70	NUM
iajs-3642	120	3	584.25	584.25	NUM
iajs-3642	120	4	3c	3c	NUM
iajs-3642	120	5	white	white	ADJ
iajs-3642	120	6	>	>	ADP
iajs-3642	120	7	300	300	NUM
iajs-3642	120	8	0.5	0.5	NUM
iajs-3642	120	9	hr	hr	NOUN
iajs-3642	120	10	.	.	PUNCT
iajs-3642	121	1	reflux	reflux	PROPN
iajs-3642	121	2	80	80	NUM
iajs-3642	121	3	454.52	454.52	NUM
iajs-3642	121	4	4a	4a	NOUN
iajs-3642	121	5	off	off	ADP
iajs-3642	121	6	white	white	ADJ
iajs-3642	121	7	gummy	gummy	ADJ
iajs-3642	121	8	15	15	NUM
iajs-3642	121	9	reflux	reflux	NOUN
iajs-3642	121	10	60	60	NUM
iajs-3642	121	11	354.37	354.37	NUM
iajs-3642	121	12	4b	4b	PROPN
iajs-3642	121	13	orange	orange	PROPN
iajs-3642	121	14	gummy	gummy	PROPN
iajs-3642	121	15	19	19	NUM
iajs-3642	121	16	hr	hr	NOUN
iajs-3642	121	17	.	.	PUNCT
iajs-3642	122	1	reflux	reflux	VERB
iajs-3642	122	2	69	69	NUM
iajs-3642	122	3	416.39	416.39	NUM
iajs-3642	122	4	4c	4c	NOUN
iajs-3642	122	5	orange	orange	ADJ
iajs-3642	122	6	108	108	NUM
iajs-3642	122	7	-	-	SYM
iajs-3642	122	8	110	110	NUM
iajs-3642	122	9	18	18	NUM
iajs-3642	122	10	reflux	reflux	NOUN
iajs-3642	122	11	75	75	NUM
iajs-3642	122	12	416.39	416.39	NUM
iajs-3642	122	13	5	5	NUM
iajs-3642	122	14	pale	pale	ADJ
iajs-3642	122	15	yellow	yellow	ADJ
iajs-3642	122	16	101	101	NUM
iajs-3642	122	17	-	-	SYM
iajs-3642	122	18	104	104	NUM
iajs-3642	122	19	5	5	NUM
iajs-3642	122	20	reflux	reflux	NOUN
iajs-3642	122	21	56	56	NUM
iajs-3642	122	22	382.42	382.42	NUM
iajs-3642	122	23	ihjpas	ihjpa	NOUN
iajs-3642	122	24	.	.	PUNCT
iajs-3642	123	1	2025	2025	NUM
iajs-3642	123	2	,	,	PUNCT
iajs-3642	123	3	38	38	NUM
iajs-3642	123	4	(	(	PUNCT
iajs-3642	123	5	1	1	NUM
iajs-3642	123	6	)	)	SYM
iajs-3642	123	7	320	320	NUM
iajs-3642	123	8	brain	brain	NOUN
iajs-3642	123	9	or	or	CCONJ
iajs-3642	123	10	bowel	bowel	NOUN
iajs-3642	123	11	penetration	penetration	NOUN
iajs-3642	123	12	method	method	NOUN
iajs-3642	123	13	and	and	CCONJ
iajs-3642	123	14	estimating	estimate	VERB
iajs-3642	123	15	tool	tool	NOUN
iajs-3642	123	16	are	be	AUX
iajs-3642	123	17	used	use	VERB
iajs-3642	123	18	.	.	PUNCT
iajs-3642	124	1	boiled	boil	VERB
iajs-3642	124	2	-	-	PUNCT
iajs-3642	124	3	egg	egg	NOUN
iajs-3642	124	4	accurately	accurately	ADV
iajs-3642	124	5	predicts	predict	VERB
iajs-3642	124	6	its	its	PRON
iajs-3642	124	7	small	small	ADJ
iajs-3642	124	8	compound	compound	NOUN
iajs-3642	124	9	's	's	PART
iajs-3642	124	10	adipogenesis	adipogenesis	NOUN
iajs-3642	124	11	and	and	CCONJ
iajs-3642	124	12	polarization	polarization	NOUN
iajs-3642	124	13	(	(	PUNCT
iajs-3642	124	14	29	29	NUM
iajs-3642	124	15	)	)	PUNCT
iajs-3642	124	16	.	.	PUNCT
iajs-3642	125	1	predictions	prediction	NOUN
iajs-3642	125	2	of	of	ADP
iajs-3642	125	3	each	each	DET
iajs-3642	125	4	brain	brain	NOUN
iajs-3642	125	5	region	region	NOUN
iajs-3642	125	6	are	be	AUX
iajs-3642	125	7	obtained	obtain	VERB
iajs-3642	125	8	depending	depend	VERB
iajs-3642	125	9	on	on	ADP
iajs-3642	125	10	physical	physical	ADJ
iajs-3642	125	11	and	and	CCONJ
iajs-3642	125	12	chemical	chemical	NOUN
iajs-3642	125	13	properties	property	NOUN
iajs-3642	125	14	and	and	CCONJ
iajs-3642	125	15	immediately	immediately	ADV
iajs-3642	125	16	converted	convert	VERB
iajs-3642	125	17	into	into	ADP
iajs-3642	125	18	the	the	DET
iajs-3642	125	19	molecular	molecular	ADJ
iajs-3642	125	20	design	design	NOUN
iajs-3642	125	21	(	(	PUNCT
iajs-3642	125	22	20	20	NUM
iajs-3642	125	23	)	)	PUNCT
iajs-3642	125	24	.	.	PUNCT
iajs-3642	126	1	the	the	DET
iajs-3642	126	2	data	datum	NOUN
iajs-3642	126	3	obtained	obtain	VERB
iajs-3642	126	4	is	be	AUX
iajs-3642	126	5	shown	show	VERB
iajs-3642	126	6	in	in	ADP
iajs-3642	126	7	table	table	NOUN
iajs-3642	126	8	2	2	NUM
iajs-3642	126	9	.	.	NOUN
iajs-3642	127	1	3	3	NUM
iajs-3642	127	2	.	.	NOUN
iajs-3642	127	3	result	result	NOUN
iajs-3642	127	4	and	and	CCONJ
iajs-3642	127	5	discussion	discussion	NOUN
iajs-3642	127	6	3.1	3.1	NUM
iajs-3642	127	7	.	.	PUNCT
iajs-3642	128	1	chemistry	chemistry	NOUN
iajs-3642	128	2	as	as	SCONJ
iajs-3642	128	3	mentioned	mention	VERB
iajs-3642	128	4	in	in	ADP
iajs-3642	128	5	the	the	DET
iajs-3642	128	6	literature	literature	NOUN
iajs-3642	128	7	,	,	PUNCT
iajs-3642	128	8	succinohydrazide	succinohydrazide	ADV
iajs-3642	128	9	was	be	AUX
iajs-3642	128	10	prepared	prepare	VERB
iajs-3642	128	11	in	in	ADP
iajs-3642	128	12	this	this	DET
iajs-3642	128	13	work	work	NOUN
iajs-3642	128	14	.	.	PUNCT
iajs-3642	129	1	it	it	PRON
iajs-3642	129	2	was	be	AUX
iajs-3642	129	3	a	a	DET
iajs-3642	129	4	precursor	precursor	NOUN
iajs-3642	129	5	for	for	ADP
iajs-3642	129	6	synthesizing	synthesize	VERB
iajs-3642	129	7	diverse	diverse	ADJ
iajs-3642	129	8	derivatives	derivative	NOUN
iajs-3642	129	9	by	by	ADP
iajs-3642	129	10	reacting	react	VERB
iajs-3642	129	11	with	with	ADP
iajs-3642	129	12	different	different	ADJ
iajs-3642	129	13	organic	organic	ADJ
iajs-3642	129	14	compounds	compound	NOUN
iajs-3642	129	15	(	(	PUNCT
iajs-3642	129	16	benzoyl	benzoyl	NOUN
iajs-3642	129	17	chloride	chloride	NOUN
iajs-3642	129	18	,	,	PUNCT
iajs-3642	129	19	sulphonyl	sulphonyl	NOUN
iajs-3642	129	20	chloride	chloride	NOUN
iajs-3642	129	21	,	,	PUNCT
iajs-3642	129	22	and	and	CCONJ
iajs-3642	129	23	phenacyl	phenacyl	VERB
iajs-3642	129	24	chloride	chloride	NOUN
iajs-3642	129	25	)	)	PUNCT
iajs-3642	129	26	.	.	PUNCT
iajs-3642	130	1	these	these	DET
iajs-3642	130	2	reactions	reaction	NOUN
iajs-3642	130	3	undergo	undergo	VERB
iajs-3642	130	4	the	the	DET
iajs-3642	130	5	nucleophilesubstitution	nucleophilesubstitution	NOUN
iajs-3642	130	6	mechanism	mechanism	NOUN
iajs-3642	130	7	.	.	PUNCT
iajs-3642	131	1	however	however	ADV
iajs-3642	131	2	,	,	PUNCT
iajs-3642	131	3	benzyl	benzyl	NOUN
iajs-3642	131	4	chloride	chloride	NOUN
iajs-3642	131	5	reactions	reaction	NOUN
iajs-3642	131	6	undergo	undergo	VERB
iajs-3642	131	7	an	an	DET
iajs-3642	131	8	unimolecular	unimolecular	ADJ
iajs-3642	131	9	nucleophilic	nucleophilic	ADJ
iajs-3642	131	10	substitution	substitution	NOUN
iajs-3642	131	11	(	(	PUNCT
iajs-3642	131	12	sn1	sn1	NOUN
iajs-3642	131	13	)	)	PUNCT
iajs-3642	131	14	mechanism	mechanism	NOUN
iajs-3642	131	15	.	.	PUNCT
iajs-3642	132	1	steps	step	VERB
iajs-3642	132	2	the	the	DET
iajs-3642	132	3	tlc	tlc	NOUN
iajs-3642	132	4	technique	technique	NOUN
iajs-3642	132	5	monitored	monitor	VERB
iajs-3642	132	6	the	the	DET
iajs-3642	132	7	synthesis	synthesis	NOUN
iajs-3642	132	8	of	of	ADP
iajs-3642	132	9	all	all	DET
iajs-3642	132	10	these	these	DET
iajs-3642	132	11	compounds	compound	NOUN
iajs-3642	132	12	,	,	PUNCT
iajs-3642	132	13	which	which	PRON
iajs-3642	132	14	was	be	AUX
iajs-3642	132	15	analyzed	analyze	VERB
iajs-3642	132	16	by	by	ADP
iajs-3642	132	17	ft	ft	PROPN
iajs-3642	132	18	-	-	PUNCT
iajs-3642	132	19	ir	ir	PROPN
iajs-3642	132	20	,	,	PUNCT
iajs-3642	132	21	1h	1h	NUM
iajs-3642	132	22	,	,	PUNCT
iajs-3642	132	23	and	and	CCONJ
iajs-3642	132	24	13c	13c	NOUN
iajs-3642	132	25	nmr	nmr	NOUN
iajs-3642	132	26	spectroscopy	spectroscopy	NOUN
iajs-3642	132	27	,	,	PUNCT
iajs-3642	132	28	as	as	SCONJ
iajs-3642	132	29	shown	show	VERB
iajs-3642	132	30	in	in	ADP
iajs-3642	132	31	scheme	scheme	NOUN
iajs-3642	132	32	1	1	NUM
iajs-3642	132	33	.	.	NOUN
iajs-3642	132	34	3.2	3.2	NUM
iajs-3642	132	35	.	.	PUNCT
iajs-3642	133	1	spectral	spectral	ADJ
iajs-3642	133	2	analysis	analysis	NOUN
iajs-3642	133	3	all	all	DET
iajs-3642	133	4	spectra	spectra	NOUN
iajs-3642	133	5	were	be	AUX
iajs-3642	133	6	interpreted	interpret	VERB
iajs-3642	133	7	by	by	ADP
iajs-3642	133	8	silverstein	silverstein	ADJ
iajs-3642	133	9	spectrometric	spectrometric	ADJ
iajs-3642	133	10	identification	identification	NOUN
iajs-3642	133	11	of	of	ADP
iajs-3642	133	12	organic	organic	ADJ
iajs-3642	133	13	compounds	compound	NOUN
iajs-3642	133	14	7th	7th	ADJ
iajs-3642	133	15	ed	ed	NOUN
iajs-3642	133	16	.	.	PUNCT
iajs-3642	134	1	(	(	PUNCT
iajs-3642	134	2	31	31	NUM
iajs-3642	134	3	)	)	PUNCT
iajs-3642	134	4	.	.	PUNCT
iajs-3642	135	1	the	the	DET
iajs-3642	135	2	existence	existence	NOUN
iajs-3642	135	3	of	of	ADP
iajs-3642	135	4	a	a	DET
iajs-3642	135	5	secondary	secondary	ADJ
iajs-3642	135	6	amine	amine	ADJ
iajs-3642	135	7	group	group	NOUN
iajs-3642	135	8	was	be	AUX
iajs-3642	135	9	indicated	indicate	VERB
iajs-3642	135	10	by	by	ADP
iajs-3642	135	11	the	the	DET
iajs-3642	135	12	absence	absence	NOUN
iajs-3642	135	13	of	of	ADP
iajs-3642	135	14	nh2	nh2	NOUN
iajs-3642	135	15	absorption	absorption	NOUN
iajs-3642	135	16	in	in	ADP
iajs-3642	135	17	succinohydrazide	succinohydrazide	ADJ
iajs-3642	135	18	3305–3286	3305–3286	NUM
iajs-3642	135	19	cm-1	cm-1	NOUN
iajs-3642	135	20	and	and	CCONJ
iajs-3642	135	21	the	the	DET
iajs-3642	135	22	appearance	appearance	NOUN
iajs-3642	135	23	of	of	ADP
iajs-3642	135	24	n	n	CCONJ
iajs-3642	135	25	-	-	PUNCT
iajs-3642	135	26	h	h	NOUN
iajs-3642	135	27	absorption	absorption	NOUN
iajs-3642	135	28	in	in	ADP
iajs-3642	135	29	the	the	DET
iajs-3642	135	30	range	range	NOUN
iajs-3642	135	31	of	of	ADP
iajs-3642	135	32	3400–3124	3400–3124	NUM
iajs-3642	135	33	cm-1	cm-1	NOUN
iajs-3642	135	34	.	.	PUNCT
iajs-3642	136	1	in	in	ADP
iajs-3642	136	2	addition	addition	NOUN
iajs-3642	136	3	,	,	PUNCT
iajs-3642	136	4	in	in	ADP
iajs-3642	136	5	derivatives	derivative	NOUN
iajs-3642	136	6	from	from	ADP
iajs-3642	136	7	2a–2e	2a–2e	NUM
iajs-3642	136	8	,	,	PUNCT
iajs-3642	136	9	the	the	DET
iajs-3642	136	10	absorption	absorption	NOUN
iajs-3642	136	11	band	band	NOUN
iajs-3642	136	12	between	between	ADP
iajs-3642	136	13	1698–1664	1698–1664	NUM
iajs-3642	136	14	cm-1	cm-1	NOUN
iajs-3642	136	15	contains	contain	VERB
iajs-3642	136	16	nhc	nhc	PROPN
iajs-3642	136	17	=	=	SYM
iajs-3642	136	18	oamidech2	oamidech2	PROPN
iajs-3642	136	19	and	and	CCONJ
iajs-3642	136	20	1669–1622	1669–1622	NUM
iajs-3642	136	21	cm-1	cm-1	NOUN
iajs-3642	136	22	contains	contain	VERB
iajs-3642	136	23	nhc	nhc	NOUN
iajs-3642	136	24	=	=	NOUN
iajs-3642	136	25	oamideph	oamideph	NOUN
iajs-3642	136	26	,	,	PUNCT
iajs-3642	136	27	whereas	whereas	SCONJ
iajs-3642	136	28	in	in	ADP
iajs-3642	136	29	3a–3c	3a–3c	ADJ
iajs-3642	136	30	derivatives	derivative	NOUN
iajs-3642	136	31	,	,	PUNCT
iajs-3642	136	32	the	the	DET
iajs-3642	136	33	absorption	absorption	NOUN
iajs-3642	136	34	band	band	NOUN
iajs-3642	136	35	between	between	ADP
iajs-3642	136	36	1688–1665	1688–1665	NUM
iajs-3642	136	37	contains	contain	VERB
iajs-3642	136	38	nhc	nhc	NOUN
iajs-3642	136	39	=	=	PRON
iajs-3642	136	40	oamide	oamide	NOUN
iajs-3642	136	41	with	with	ADP
iajs-3642	136	42	the	the	DET
iajs-3642	136	43	presence	presence	NOUN
iajs-3642	136	44	of	of	ADP
iajs-3642	136	45	two	two	NUM
iajs-3642	136	46	bands	band	NOUN
iajs-3642	136	47	of	of	ADP
iajs-3642	136	48	so2	so2	PROPN
iajs-3642	136	49	between	between	ADP
iajs-3642	136	50	1386–1362	1386–1362	NUM
iajs-3642	136	51	and	and	CCONJ
iajs-3642	136	52	1174–1159	1174–1159	NUM
iajs-3642	136	53	.	.	PUNCT
iajs-3642	137	1	4a–4c	4a–4c	NOUN
iajs-3642	137	2	illustrate	illustrate	VERB
iajs-3642	137	3	the	the	DET
iajs-3642	137	4	existence	existence	NOUN
iajs-3642	137	5	of	of	ADP
iajs-3642	137	6	nhc	nhc	PROPN
iajs-3642	137	7	=	=	PROPN
iajs-3642	137	8	oamidech2	oamidech2	PROPN
iajs-3642	137	9	between	between	ADP
iajs-3642	137	10	1668	1668	NUM
iajs-3642	137	11	and	and	CCONJ
iajs-3642	137	12	1664	1664	NUM
iajs-3642	137	13	and	and	CCONJ
iajs-3642	137	14	are	be	AUX
iajs-3642	137	15	distinguished	distinguish	VERB
iajs-3642	137	16	by	by	ADP
iajs-3642	137	17	the	the	DET
iajs-3642	137	18	appearance	appearance	NOUN
iajs-3642	137	19	of	of	ADP
iajs-3642	137	20	two	two	NUM
iajs-3642	137	21	strong	strong	ADJ
iajs-3642	137	22	bands	band	NOUN
iajs-3642	137	23	,	,	PUNCT
iajs-3642	137	24	1521–1510	1521–1510	NUM
iajs-3642	137	25	and	and	CCONJ
iajs-3642	137	26	1339–1319	1339–1319	NUM
iajs-3642	137	27	,	,	PUNCT
iajs-3642	137	28	corresponding	correspond	VERB
iajs-3642	137	29	to	to	ADP
iajs-3642	137	30	no2	no2	PROPN
iajs-3642	137	31	.	.	PUNCT
iajs-3642	138	1	the	the	DET
iajs-3642	138	2	bands	band	NOUN
iajs-3642	138	3	observed	observe	VERB
iajs-3642	138	4	in	in	ADP
iajs-3642	138	5	1717	1717	NUM
iajs-3642	138	6	c	c	NOUN
iajs-3642	138	7	=	=	NOUN
iajs-3642	138	8	oketone	oketone	ADJ
iajs-3642	138	9	and	and	CCONJ
iajs-3642	138	10	1686	1686	NUM
iajs-3642	138	11	c	c	X
iajs-3642	138	12	=	=	PRON
iajs-3642	138	13	oamide	oamide	NOUN
iajs-3642	138	14	are	be	AUX
iajs-3642	138	15	present	present	ADJ
iajs-3642	138	16	in	in	ADP
iajs-3642	138	17	phenacyl	phenacyl	NOUN
iajs-3642	138	18	derivative	derivative	ADJ
iajs-3642	138	19	5	5	NUM
iajs-3642	138	20	.	.	PUNCT
iajs-3642	139	1	the	the	DET
iajs-3642	139	2	signal	signal	NOUN
iajs-3642	139	3	in	in	ADP
iajs-3642	139	4	the	the	DET
iajs-3642	139	5	1h	1h	NUM
iajs-3642	139	6	nmr	nmr	NOUN
iajs-3642	139	7	spectra	spectra	NOUN
iajs-3642	139	8	for	for	ADP
iajs-3642	139	9	derivative	derivative	ADJ
iajs-3642	139	10	1	1	NUM
iajs-3642	139	11	is	be	AUX
iajs-3642	139	12	8.98	8.98	NUM
iajs-3642	139	13	for	for	ADP
iajs-3642	139	14	nh	nh	NOUN
iajs-3642	139	15	-	-	PUNCT
iajs-3642	139	16	c	c	NOUN
iajs-3642	139	17	=	=	NOUN
iajs-3642	139	18	o	o	NOUN
iajs-3642	139	19	and	and	CCONJ
iajs-3642	139	20	4.14	4.14	NUM
iajs-3642	139	21	for	for	ADP
iajs-3642	139	22	free	free	ADJ
iajs-3642	139	23	nh2	nh2	PROPN
iajs-3642	139	24	.	.	PUNCT
iajs-3642	140	1	signals	signal	NOUN
iajs-3642	140	2	are	be	AUX
iajs-3642	140	3	seen	see	VERB
iajs-3642	140	4	at	at	ADP
iajs-3642	140	5	10.47–10.17	10.47–10.17	NUM
iajs-3642	140	6	ppm	ppm	NOUN
iajs-3642	140	7	for	for	ADP
iajs-3642	140	8	nh	nh	PROPN
iajs-3642	140	9	adjacent	adjacent	ADJ
iajs-3642	140	10	to	to	ADP
iajs-3642	140	11	phc	phc	PROPN
iajs-3642	140	12	=	=	PRON
iajs-3642	140	13	oamide	oamide	NOUN
iajs-3642	140	14	and	and	CCONJ
iajs-3642	140	15	10.04–9.89	10.04–9.89	NUM
iajs-3642	140	16	ppm	ppm	NOUN
iajs-3642	140	17	for	for	ADP
iajs-3642	140	18	nh	nh	PROPN
iajs-3642	140	19	adjacent	adjacent	ADJ
iajs-3642	140	20	to	to	ADP
iajs-3642	140	21	ch2c	ch2c	PROPN
iajs-3642	140	22	=	=	PRON
iajs-3642	140	23	oamid	oamid	NOUN
iajs-3642	140	24	in	in	ADP
iajs-3642	140	25	2a–2e	2a–2e	NUM
iajs-3642	140	26	.	.	PUNCT
iajs-3642	141	1	furthermore	furthermore	ADV
iajs-3642	141	2	,	,	PUNCT
iajs-3642	141	3	3b	3b	NUM
iajs-3642	141	4	and	and	CCONJ
iajs-3642	141	5	3c	3c	NUM
iajs-3642	141	6	show	show	NOUN
iajs-3642	141	7	signals	signal	NOUN
iajs-3642	141	8	in	in	ADP
iajs-3642	141	9	10.97	10.97	NUM
iajs-3642	141	10	,	,	PUNCT
iajs-3642	141	11	10.91	10.91	NUM
iajs-3642	141	12	for	for	ADP
iajs-3642	141	13	nh	nh	PROPN
iajs-3642	141	14	-	-	PUNCT
iajs-3642	141	15	so2	so2	PROPN
iajs-3642	141	16	and	and	CCONJ
iajs-3642	141	17	10.46	10.46	NUM
iajs-3642	141	18	,	,	PUNCT
iajs-3642	141	19	9.78	9.78	NUM
iajs-3642	141	20	for	for	ADP
iajs-3642	141	21	nhc	nhc	NOUN
iajs-3642	141	22	=	=	SYM
iajs-3642	141	23	oamid	oamid	NOUN
iajs-3642	141	24	,	,	PUNCT
iajs-3642	141	25	while	while	SCONJ
iajs-3642	141	26	4c	4c	NOUN
iajs-3642	141	27	shows	show	VERB
iajs-3642	141	28	signals	signal	NOUN
iajs-3642	141	29	in	in	ADP
iajs-3642	141	30	9.01	9.01	NUM
iajs-3642	141	31	for	for	ADP
iajs-3642	141	32	nh	nh	NOUN
iajs-3642	141	33	-	-	PUNCT
iajs-3642	141	34	c	c	NOUN
iajs-3642	141	35	=	=	NOUN
iajs-3642	141	36	o	o	NOUN
iajs-3642	141	37	,	,	PUNCT
iajs-3642	141	38	5.35	5.35	NUM
iajs-3642	141	39	for	for	ADP
iajs-3642	141	40	nh	nh	NOUN
iajs-3642	141	41	-	-	PUNCT
iajs-3642	141	42	ch2	ch2	PROPN
iajs-3642	141	43	,	,	PUNCT
iajs-3642	141	44	and	and	CCONJ
iajs-3642	141	45	4.13	4.13	NUM
iajs-3642	141	46	for	for	ADP
iajs-3642	141	47	ch2	ch2	NOUN
iajs-3642	141	48	-	-	PUNCT
iajs-3642	141	49	ph	ph	ADJ
iajs-3642	141	50	.	.	PROPN
iajs-3642	141	51	13c	13c	NOUN
iajs-3642	141	52	nmr	nmr	NOUN
iajs-3642	141	53	indicates	indicate	VERB
iajs-3642	141	54	signals	signal	NOUN
iajs-3642	141	55	in	in	ADP
iajs-3642	141	56	171.12	171.12	NUM
iajs-3642	141	57	to	to	ADP
iajs-3642	141	58	170.98	170.98	NUM
iajs-3642	141	59	ppm	ppm	NOUN
iajs-3642	141	60	for	for	ADP
iajs-3642	141	61	ch2c	ch2c	PROPN
iajs-3642	141	62	=	=	SYM
iajs-3642	141	63	oamid	oamid	NOUN
iajs-3642	141	64	and	and	CCONJ
iajs-3642	141	65	165.92	165.92	NUM
iajs-3642	141	66	to	to	ADP
iajs-3642	141	67	164.53	164.53	NUM
iajs-3642	141	68	ppm	ppm	NOUN
iajs-3642	141	69	for	for	ADP
iajs-3642	141	70	phc	phc	NOUN
iajs-3642	141	71	=	=	NOUN
iajs-3642	141	72	oamide	oamide	NOUN
iajs-3642	141	73	.	.	PUNCT
iajs-3642	142	1	signals	signal	NOUN
iajs-3642	142	2	173.77	173.77	NUM
iajs-3642	142	3	and	and	CCONJ
iajs-3642	142	4	170.92	170.92	NUM
iajs-3642	142	5	for	for	ADP
iajs-3642	142	6	nh	nh	NOUN
iajs-3642	142	7	-	-	PUNCT
iajs-3642	142	8	c	c	NOUN
iajs-3642	142	9	=	=	NOUN
iajs-3642	142	10	o	o	NOUN
iajs-3642	142	11	appear	appear	VERB
iajs-3642	142	12	in	in	ADP
iajs-3642	142	13	sulphonyl	sulphonyl	NOUN
iajs-3642	142	14	derivatives	derivative	NOUN
iajs-3642	142	15	3b	3b	NOUN
iajs-3642	142	16	and	and	CCONJ
iajs-3642	142	17	3c	3c	NUM
iajs-3642	142	18	.	.	PUNCT
iajs-3642	143	1	finally	finally	ADV
iajs-3642	143	2	,	,	PUNCT
iajs-3642	143	3	4c	4c	NOUN
iajs-3642	143	4	shows	show	VERB
iajs-3642	143	5	c	c	NOUN
iajs-3642	143	6	=	=	NOUN
iajs-3642	143	7	oamid	oamid	ADJ
iajs-3642	143	8	at	at	ADP
iajs-3642	143	9	170.99	170.99	NUM
iajs-3642	143	10	and	and	CCONJ
iajs-3642	143	11	ph	ph	NOUN
iajs-3642	143	12	-	-	NOUN
iajs-3642	143	13	ch2	ch2	NOUN
iajs-3642	143	14	at	at	ADP
iajs-3642	143	15	54.18	54.18	NUM
iajs-3642	143	16	.	.	PUNCT
iajs-3642	144	1	as	as	ADP
iajs-3642	144	2	a	a	DET
iajs-3642	144	3	consequence	consequence	NOUN
iajs-3642	144	4	,	,	PUNCT
iajs-3642	144	5	the	the	DET
iajs-3642	144	6	synthesis	synthesis	NOUN
iajs-3642	144	7	of	of	ADP
iajs-3642	144	8	derivatives	derivative	NOUN
iajs-3642	144	9	is	be	AUX
iajs-3642	144	10	approved	approve	VERB
iajs-3642	144	11	.	.	PUNCT
iajs-3642	145	1	3.3	3.3	NUM
iajs-3642	145	2	.	.	PUNCT
iajs-3642	146	1	in	in	ADP
iajs-3642	146	2	silico	silico	NOUN
iajs-3642	146	3	pharmacokinetics	pharmacokinetic	NOUN
iajs-3642	146	4	adme	adme	VERB
iajs-3642	146	5	properties	property	NOUN
iajs-3642	146	6	when	when	SCONJ
iajs-3642	146	7	synthesized	synthesize	VERB
iajs-3642	146	8	compounds	compound	NOUN
iajs-3642	146	9	exhibit	exhibit	VERB
iajs-3642	146	10	strong	strong	ADJ
iajs-3642	146	11	adme	adme	NOUN
iajs-3642	146	12	qualities	quality	NOUN
iajs-3642	146	13	,	,	PUNCT
iajs-3642	146	14	they	they	PRON
iajs-3642	146	15	may	may	AUX
iajs-3642	146	16	be	be	AUX
iajs-3642	146	17	considered	consider	VERB
iajs-3642	146	18	excellent	excellent	ADJ
iajs-3642	146	19	candidates	candidate	NOUN
iajs-3642	146	20	for	for	ADP
iajs-3642	146	21	drug	drug	NOUN
iajs-3642	146	22	-	-	PUNCT
iajs-3642	146	23	like	like	ADJ
iajs-3642	146	24	properties	property	NOUN
iajs-3642	146	25	.	.	PUNCT
iajs-3642	147	1	oral	oral	ADJ
iajs-3642	147	2	bioavailability	bioavailability	NOUN
iajs-3642	147	3	is	be	AUX
iajs-3642	147	4	more	more	ADV
iajs-3642	147	5	likely	likely	ADJ
iajs-3642	147	6	in	in	ADP
iajs-3642	147	7	molecules	molecule	NOUN
iajs-3642	147	8	with	with	ADP
iajs-3642	147	9	five	five	NUM
iajs-3642	147	10	hydrogen	hydrogen	NOUN
iajs-3642	147	11	bond	bond	NOUN
iajs-3642	147	12	donors	donor	NOUN
iajs-3642	147	13	hbd	hbd	NOUN
iajs-3642	147	14	,	,	PUNCT
iajs-3642	147	15	ten	ten	NUM
iajs-3642	147	16	hydrogen	hydrogen	NOUN
iajs-3642	147	17	bond	bond	NOUN
iajs-3642	147	18	accepter	accepter	X
iajs-3642	147	19	hba	hba	PROPN
iajs-3642	147	20	,	,	PUNCT
iajs-3642	147	21	a	a	DET
iajs-3642	147	22	molecular	molecular	ADJ
iajs-3642	147	23	weight	weight	NOUN
iajs-3642	147	24	<	<	X
iajs-3642	147	25	500	500	NUM
iajs-3642	147	26	g	g	NOUN
iajs-3642	147	27	/	/	SYM
iajs-3642	147	28	mol	mol	NOUN
iajs-3642	147	29	,	,	PUNCT
iajs-3642	147	30	and	and	CCONJ
iajs-3642	147	31	a	a	DET
iajs-3642	147	32	calculated	calculate	VERB
iajs-3642	147	33	log	log	NOUN
iajs-3642	147	34	p	p	X
iajs-3642	147	35	<	<	X
iajs-3642	147	36	5	5	NUM
iajs-3642	147	37	(	(	PUNCT
iajs-3642	147	38	20	20	NUM
iajs-3642	147	39	)	)	PUNCT
iajs-3642	147	40	.	.	PUNCT
iajs-3642	148	1	orally	orally	ADV
iajs-3642	148	2	inactive	inactive	ADJ
iajs-3642	148	3	compounds	compound	NOUN
iajs-3642	148	4	violate	violate	VERB
iajs-3642	148	5	at	at	ADV
iajs-3642	148	6	least	least	ADV
iajs-3642	148	7	two	two	NUM
iajs-3642	148	8	of	of	ADP
iajs-3642	148	9	the	the	DET
iajs-3642	148	10	five	five	NUM
iajs-3642	148	11	rules	rule	NOUN
iajs-3642	148	12	(	(	PUNCT
iajs-3642	148	13	32	32	NUM
iajs-3642	148	14	)	)	PUNCT
iajs-3642	148	15	.	.	PUNCT
iajs-3642	149	1	the	the	DET
iajs-3642	149	2	results	result	NOUN
iajs-3642	149	3	in	in	ADP
iajs-3642	149	4	table	table	NOUN
iajs-3642	149	5	2	2	NUM
iajs-3642	149	6	indicate	indicate	VERB
iajs-3642	149	7	that	that	SCONJ
iajs-3642	149	8	all	all	DET
iajs-3642	149	9	synthesis	synthesis	NOUN
iajs-3642	149	10	compounds	compound	VERB
iajs-3642	149	11	2a	2a	NUM
iajs-3642	149	12	to	to	PART
iajs-3642	149	13	5	5	NUM
iajs-3642	149	14	have	have	VERB
iajs-3642	149	15	no	no	DET
iajs-3642	149	16	violations	violation	NOUN
iajs-3642	149	17	of	of	ADP
iajs-3642	149	18	lipinski	lipinski	PROPN
iajs-3642	149	19	’s	’s	PART
iajs-3642	149	20	rule	rule	NOUN
iajs-3642	149	21	except	except	SCONJ
iajs-3642	149	22	for	for	ADP
iajs-3642	149	23	3b	3b	NUM
iajs-3642	149	24	,	,	PUNCT
iajs-3642	149	25	which	which	PRON
iajs-3642	149	26	was	be	AUX
iajs-3642	149	27	excluded	exclude	VERB
iajs-3642	149	28	from	from	ADP
iajs-3642	149	29	the	the	DET
iajs-3642	149	30	molecular	molecular	ADJ
iajs-3642	149	31	docking	docking	NOUN
iajs-3642	149	32	study	study	NOUN
iajs-3642	149	33	according	accord	VERB
iajs-3642	149	34	to	to	ADP
iajs-3642	149	35	the	the	DET
iajs-3642	149	36	adme	adme	NOUN
iajs-3642	149	37	result	result	NOUN
iajs-3642	149	38	.	.	PUNCT
iajs-3642	150	1	it	it	PRON
iajs-3642	150	2	has	have	VERB
iajs-3642	150	3	one	one	NUM
iajs-3642	150	4	violation	violation	NOUN
iajs-3642	150	5	in	in	ADP
iajs-3642	150	6	m.wt	m.wt	PROPN
iajs-3642	150	7	.	.	PROPN
iajs-3642	150	8	that	that	PRON
iajs-3642	150	9	exceeded	exceed	VERB
iajs-3642	150	10	500	500	NUM
iajs-3642	150	11	g	g	NOUN
iajs-3642	150	12	/	/	SYM
iajs-3642	150	13	mol	mol	NOUN
iajs-3642	150	14	,	,	PUNCT
iajs-3642	150	15	and	and	CCONJ
iajs-3642	150	16	all	all	DET
iajs-3642	150	17	compounds	compound	NOUN
iajs-3642	150	18	ihjpas	ihjpa	NOUN
iajs-3642	150	19	.	.	PUNCT
iajs-3642	151	1	2025	2025	NUM
iajs-3642	151	2	,	,	PUNCT
iajs-3642	151	3	38	38	NUM
iajs-3642	151	4	(	(	PUNCT
iajs-3642	151	5	1	1	NUM
iajs-3642	151	6	)	)	PUNCT
iajs-3642	151	7	321	321	NUM
iajs-3642	151	8	2a	2a	NUM
iajs-3642	151	9	to	to	ADP
iajs-3642	151	10	5	5	NUM
iajs-3642	151	11	have	have	VERB
iajs-3642	151	12	the	the	DET
iajs-3642	151	13	highest	high	ADJ
iajs-3642	151	14	docking	docking	NOUN
iajs-3642	151	15	scores	score	NOUN
iajs-3642	151	16	by	by	ADP
iajs-3642	151	17	hydrogen	hydrogen	NOUN
iajs-3642	151	18	bonds	bond	NOUN
iajs-3642	151	19	with	with	ADP
iajs-3642	151	20	the	the	DET
iajs-3642	151	21	target	target	NOUN
iajs-3642	151	22	protein	protein	NOUN
iajs-3642	151	23	(	(	PUNCT
iajs-3642	151	24	1sa0	1sa0	NUM
iajs-3642	151	25	)	)	PUNCT
iajs-3642	151	26	.	.	PUNCT
iajs-3642	152	1	the	the	DET
iajs-3642	152	2	log	log	NOUN
iajs-3642	152	3	shows	show	VERB
iajs-3642	152	4	no	no	PRON
iajs-3642	152	5	exceeding	exceed	VERB
iajs-3642	152	6	the	the	DET
iajs-3642	152	7	normal	normal	ADJ
iajs-3642	152	8	range	range	NOUN
iajs-3642	152	9	for	for	ADP
iajs-3642	152	10	any	any	PRON
iajs-3642	152	11	of	of	ADP
iajs-3642	152	12	the	the	DET
iajs-3642	152	13	compounds	compound	NOUN
iajs-3642	152	14	.	.	PUNCT
iajs-3642	153	1	in	in	ADP
iajs-3642	153	2	the	the	DET
iajs-3642	153	3	lipinski	lipinski	PROPN
iajs-3642	153	4	rule	rule	NOUN
iajs-3642	153	5	of	of	ADP
iajs-3642	153	6	five	five	NUM
iajs-3642	153	7	,	,	PUNCT
iajs-3642	153	8	a	a	DET
iajs-3642	153	9	score	score	NOUN
iajs-3642	153	10	of	of	ADP
iajs-3642	153	11	0.55	0.55	NUM
iajs-3642	153	12	indicates	indicate	VERB
iajs-3642	153	13	strong	strong	ADJ
iajs-3642	153	14	bioavailability	bioavailability	NOUN
iajs-3642	153	15	and	and	CCONJ
iajs-3642	153	16	permeability	permeability	NOUN
iajs-3642	153	17	.	.	PUNCT
iajs-3642	154	1	it	it	PRON
iajs-3642	154	2	was	be	AUX
iajs-3642	154	3	estimated	estimate	VERB
iajs-3642	154	4	that	that	SCONJ
iajs-3642	154	5	the	the	DET
iajs-3642	154	6	topological	topological	ADJ
iajs-3642	154	7	polar	polar	ADJ
iajs-3642	154	8	surface	surface	NOUN
iajs-3642	154	9	area	area	NOUN
iajs-3642	154	10	(	(	PUNCT
iajs-3642	154	11	tpsa	tpsa	PROPN
iajs-3642	154	12	)	)	PUNCT
iajs-3642	154	13	indicates	indicate	VERB
iajs-3642	154	14	drug	drug	NOUN
iajs-3642	154	15	bioavailability	bioavailability	NOUN
iajs-3642	154	16	.	.	PUNCT
iajs-3642	155	1	oral	oral	ADJ
iajs-3642	155	2	bioavailability	bioavailability	NOUN
iajs-3642	155	3	is	be	AUX
iajs-3642	155	4	likely	likely	ADV
iajs-3642	155	5	low	low	ADJ
iajs-3642	155	6	for	for	ADP
iajs-3642	155	7	substances	substance	NOUN
iajs-3642	155	8	with	with	ADP
iajs-3642	155	9	a	a	DET
iajs-3642	155	10	tpsa	tpsa	NOUN
iajs-3642	155	11	greater	great	ADJ
iajs-3642	155	12	than	than	ADP
iajs-3642	155	13	140	140	NUM
iajs-3642	155	14	that	that	PRON
iajs-3642	155	15	are	be	AUX
iajs-3642	155	16	passively	passively	ADV
iajs-3642	155	17	absorbed	absorb	VERB
iajs-3642	155	18	;	;	PUNCT
iajs-3642	155	19	therefore	therefore	ADV
iajs-3642	155	20	,	,	PUNCT
iajs-3642	155	21	all	all	DET
iajs-3642	155	22	prepared	prepare	VERB
iajs-3642	155	23	compounds	compound	NOUN
iajs-3642	155	24	fulfill	fulfill	VERB
iajs-3642	155	25	this	this	DET
iajs-3642	155	26	condition	condition	NOUN
iajs-3642	155	27	except	except	SCONJ
iajs-3642	155	28	for	for	ADP
iajs-3642	155	29	3a	3a	NUM
iajs-3642	155	30	,	,	PUNCT
iajs-3642	155	31	3b	3b	NUM
iajs-3642	155	32	,	,	PUNCT
iajs-3642	155	33	3c	3c	NUM
iajs-3642	155	34	,	,	PUNCT
iajs-3642	155	35	4b	4b	X
iajs-3642	155	36	,	,	PUNCT
iajs-3642	155	37	and	and	CCONJ
iajs-3642	155	38	4c	4c	NOUN
iajs-3642	155	39	.	.	PUNCT
iajs-3642	156	1	the	the	DET
iajs-3642	156	2	boiled	boil	VERB
iajs-3642	156	3	-	-	PUNCT
iajs-3642	156	4	egg	egg	NOUN
iajs-3642	156	5	study	study	NOUN
iajs-3642	156	6	2b	2b	NOUN
iajs-3642	156	7	has	have	VERB
iajs-3642	156	8	high	high	ADJ
iajs-3642	156	9	absorption	absorption	NOUN
iajs-3642	156	10	in	in	ADP
iajs-3642	156	11	the	the	DET
iajs-3642	156	12	gastrointestinal	gastrointestinal	ADJ
iajs-3642	156	13	absorption	absorption	NOUN
iajs-3642	156	14	score	score	NOUN
iajs-3642	156	15	(	(	PUNCT
iajs-3642	156	16	gi	gi	ADP
iajs-3642	156	17	absorption	absorption	NOUN
iajs-3642	156	18	score	score	NOUN
iajs-3642	156	19	)	)	PUNCT
iajs-3642	156	20	,	,	PUNCT
iajs-3642	156	21	which	which	PRON
iajs-3642	156	22	estimates	estimate	VERB
iajs-3642	156	23	how	how	SCONJ
iajs-3642	156	24	well	well	ADV
iajs-3642	156	25	a	a	DET
iajs-3642	156	26	molecule	molecule	NOUN
iajs-3642	156	27	is	be	AUX
iajs-3642	156	28	absorbed	absorb	VERB
iajs-3642	156	29	in	in	ADP
iajs-3642	156	30	the	the	DET
iajs-3642	156	31	small	small	ADJ
iajs-3642	156	32	intestine	intestine	NOUN
iajs-3642	156	33	after	after	ADP
iajs-3642	156	34	being	be	AUX
iajs-3642	156	35	taken	take	VERB
iajs-3642	156	36	orally	orally	ADV
iajs-3642	156	37	and	and	CCONJ
iajs-3642	156	38	has	have	VERB
iajs-3642	156	39	excellent	excellent	ADJ
iajs-3642	156	40	pharmacokinetic	pharmacokinetic	ADJ
iajs-3642	156	41	qualities	quality	NOUN
iajs-3642	156	42	based	base	VERB
iajs-3642	156	43	on	on	ADP
iajs-3642	156	44	the	the	DET
iajs-3642	156	45	obtained	obtain	VERB
iajs-3642	156	46	results	result	NOUN
iajs-3642	156	47	.	.	PUNCT
iajs-3642	157	1	if	if	SCONJ
iajs-3642	157	2	the	the	DET
iajs-3642	157	3	result	result	NOUN
iajs-3642	157	4	were	be	AUX
iajs-3642	157	5	high	high	ADJ
iajs-3642	157	6	,	,	PUNCT
iajs-3642	157	7	the	the	DET
iajs-3642	157	8	absorption	absorption	NOUN
iajs-3642	157	9	would	would	AUX
iajs-3642	157	10	be	be	AUX
iajs-3642	157	11	high	high	ADJ
iajs-3642	157	12	.	.	PUNCT
iajs-3642	158	1	the	the	DET
iajs-3642	158	2	swiss	swiss	ADJ
iajs-3642	158	3	adme	adme	PROPN
iajs-3642	158	4	software	software	NOUN
iajs-3642	158	5	has	have	AUX
iajs-3642	158	6	also	also	ADV
iajs-3642	158	7	studied	study	VERB
iajs-3642	158	8	the	the	DET
iajs-3642	158	9	blood	blood	NOUN
iajs-3642	158	10	-	-	PUNCT
iajs-3642	158	11	brain	brain	NOUN
iajs-3642	158	12	barrier	barrier	NOUN
iajs-3642	158	13	(	(	PUNCT
iajs-3642	158	14	bbb	bbb	NOUN
iajs-3642	158	15	)	)	PUNCT
iajs-3642	158	16	permeant	permeant	NOUN
iajs-3642	158	17	.	.	PUNCT
iajs-3642	159	1	all	all	DET
iajs-3642	159	2	synthesized	synthesize	VERB
iajs-3642	159	3	compounds	compound	NOUN
iajs-3642	159	4	have	have	VERB
iajs-3642	159	5	no	no	DET
iajs-3642	159	6	(	(	PUNCT
iajs-3642	159	7	bbb	bbb	NOUN
iajs-3642	159	8	)	)	PUNCT
iajs-3642	159	9	,	,	PUNCT
iajs-3642	159	10	indicating	indicate	VERB
iajs-3642	159	11	they	they	PRON
iajs-3642	159	12	are	be	AUX
iajs-3642	159	13	n’t	not	PART
iajs-3642	159	14	bbb	bbb	X
iajs-3642	159	15	permeant	permeant	NOUN
iajs-3642	159	16	.	.	PUNCT
iajs-3642	160	1	2a	2a	NUM
iajs-3642	160	2	,	,	PUNCT
iajs-3642	160	3	2c	2c	NUM
iajs-3642	160	4	,	,	PUNCT
iajs-3642	160	5	2d	2d	NOUN
iajs-3642	160	6	,	,	PUNCT
iajs-3642	160	7	2e	2e	NUM
iajs-3642	160	8	,	,	PUNCT
iajs-3642	160	9	4a	4a	NOUN
iajs-3642	160	10	,	,	PUNCT
iajs-3642	160	11	and	and	CCONJ
iajs-3642	160	12	5	5	NUM
iajs-3642	160	13	;	;	PUNCT
iajs-3642	160	14	these	these	DET
iajs-3642	160	15	derivatives	derivative	NOUN
iajs-3642	160	16	expect	expect	VERB
iajs-3642	160	17	to	to	PART
iajs-3642	160	18	achieve	achieve	VERB
iajs-3642	160	19	high	high	ADJ
iajs-3642	160	20	absorption	absorption	NOUN
iajs-3642	160	21	in	in	ADP
iajs-3642	160	22	the	the	DET
iajs-3642	160	23	digestive	digestive	ADJ
iajs-3642	160	24	system	system	NOUN
iajs-3642	160	25	but	but	CCONJ
iajs-3642	160	26	are	be	AUX
iajs-3642	160	27	n’t	not	PART
iajs-3642	160	28	penetrated	penetrate	VERB
iajs-3642	160	29	in	in	ADP
iajs-3642	160	30	the	the	DET
iajs-3642	160	31	central	central	ADJ
iajs-3642	160	32	nervous	nervous	ADJ
iajs-3642	160	33	system	system	NOUN
iajs-3642	160	34	(	(	PUNCT
iajs-3642	160	35	cns	cns	NOUN
iajs-3642	160	36	)	)	PUNCT
iajs-3642	160	37	by	by	ADP
iajs-3642	160	38	p	p	NOUN
iajs-3642	160	39	-	-	PUNCT
iajs-3642	160	40	glycoprotein	glycoprotein	NOUN
iajs-3642	160	41	.	.	PUNCT
iajs-3642	161	1	this	this	DET
iajs-3642	161	2	data	data	NOUN
iajs-3642	161	3	is	be	AUX
iajs-3642	161	4	illustrated	illustrate	VERB
iajs-3642	161	5	in	in	ADP
iajs-3642	161	6	tables	table	NOUN
iajs-3642	161	7	2	2	NUM
iajs-3642	161	8	,	,	PUNCT
iajs-3642	161	9	3	3	NUM
iajs-3642	161	10	and	and	CCONJ
iajs-3642	161	11	figure	figure	VERB
iajs-3642	161	12	1	1	NUM
iajs-3642	161	13	.	.	PUNCT
iajs-3642	161	14	table	table	NOUN
iajs-3642	161	15	2	2	NUM
iajs-3642	161	16	.	.	PUNCT
iajs-3642	161	17	predicted	predict	VERB
iajs-3642	161	18	adme	adme	NOUN
iajs-3642	161	19	properties	property	NOUN
iajs-3642	161	20	of	of	ADP
iajs-3642	161	21	the	the	DET
iajs-3642	161	22	synthesized	synthesize	VERB
iajs-3642	161	23	compounds	compound	NOUN
iajs-3642	161	24	.	.	PUNCT
iajs-3642	162	1	physiochemical	physiochemical	ADJ
iajs-3642	162	2	properties	property	NOUN
iajs-3642	162	3	medicinal	medicinal	ADJ
iajs-3642	162	4	chemistry	chemistry	NOUN
iajs-3642	162	5	drug	drug	NOUN
iajs-3642	162	6	linkness	linkness	ADJ
iajs-3642	162	7	pharmacokinetics	pharmacokinetic	NOUN
iajs-3642	162	8	comp	comp	NOUN
iajs-3642	162	9	.	.	PUNCT
iajs-3642	163	1	no	no	INTJ
iajs-3642	163	2	.	.	PUNCT
iajs-3642	163	3	m.wta	m.wta	INTJ
iajs-3642	163	4	(	(	PUNCT
iajs-3642	163	5	≤	≤	NOUN
iajs-3642	163	6	500	500	NUM
iajs-3642	163	7	)	)	PUNCT
iajs-3642	163	8	no	no	DET
iajs-3642	163	9	hbdb	hbdb	NOUN
iajs-3642	163	10	(	(	PUNCT
iajs-3642	163	11	≤	≤	NOUN
iajs-3642	163	12	5	5	NUM
iajs-3642	163	13	)	)	PUNCT
iajs-3642	163	14	no	no	DET
iajs-3642	163	15	hbac	hbac	NOUN
iajs-3642	163	16	(	(	PUNCT
iajs-3642	163	17	≤	≤	NUM
iajs-3642	163	18	10	10	NUM
iajs-3642	163	19	)	)	PUNCT
iajs-3642	163	20	no	no	DET
iajs-3642	163	21	rbd	rbd	NOUN
iajs-3642	163	22	tpsae	tpsae	NOUN
iajs-3642	163	23	(	(	PUNCT
iajs-3642	163	24	å²	å²	PROPN
iajs-3642	163	25	)	)	PUNCT
iajs-3642	163	26	log	log	VERB
iajs-3642	163	27	po	po	NOUN
iajs-3642	163	28	/	/	SYM
iajs-3642	163	29	w	w	PROPN
iajs-3642	163	30	(	(	PUNCT
iajs-3642	163	31	ilogp)f	ilogp)f	PROPN
iajs-3642	163	32	(	(	PUNCT
iajs-3642	163	33	≤	≤	NOUN
iajs-3642	163	34	5	5	NUM
iajs-3642	163	35	)	)	PUNCT
iajs-3642	163	36	synthetic	synthetic	ADJ
iajs-3642	163	37	accessibility	accessibility	NOUN
iajs-3642	163	38	b.sg	b.sg	NOUN
iajs-3642	163	39	p	p	NOUN
iajs-3642	163	40	-	-	PUNCT
iajs-3642	163	41	gph	gph	NOUN
iajs-3642	163	42	bbb	bbb	NOUN
iajs-3642	163	43	permeanti	permeanti	NOUN
iajs-3642	163	44	gi	gi	PROPN
iajs-3642	163	45	absj	absj	PROPN
iajs-3642	163	46	2a	2a	CCONJ
iajs-3642	164	1	354.37	354.37	NUM
iajs-3642	164	2	4	4	NUM
iajs-3642	164	3	4	4	NUM
iajs-3642	164	4	11	11	NUM
iajs-3642	164	5	116.40	116.40	NUM
iajs-3642	164	6	1.80	1.80	NUM
iajs-3642	164	7	2.41	2.41	NUM
iajs-3642	164	8	0.55	0.55	NUM
iajs-3642	164	9	no	no	PRON
iajs-3642	164	10	no	no	DET
iajs-3642	164	11	high	high	ADJ
iajs-3642	164	12	2b	2b	NOUN
iajs-3642	164	13	414.42	414.42	NUM
iajs-3642	164	14	4	4	NUM
iajs-3642	164	15	6	6	NUM
iajs-3642	164	16	13	13	NUM
iajs-3642	164	17	134.88	134.88	NUM
iajs-3642	164	18	2.53	2.53	NUM
iajs-3642	164	19	2.67	2.67	NUM
iajs-3642	164	20	0.55	0.55	NUM
iajs-3642	164	21	yes	yes	INTJ
iajs-3642	164	22	no	no	DET
iajs-3642	164	23	high	high	ADJ
iajs-3642	164	24	2c	2c	NOUN
iajs-3642	164	25	423.25	423.25	NUM
iajs-3642	164	26	4	4	NUM
iajs-3642	164	27	4	4	NUM
iajs-3642	164	28	11	11	NUM
iajs-3642	164	29	116.40	116.40	NUM
iajs-3642	164	30	2.06	2.06	NUM
iajs-3642	164	31	2.61	2.61	NUM
iajs-3642	164	32	0.55	0.55	NUM
iajs-3642	164	33	no	no	PRON
iajs-3642	164	34	no	no	DET
iajs-3642	164	35	high	high	ADJ
iajs-3642	164	36	2d	2d	NOUN
iajs-3642	164	37	423.25	423.25	NUM
iajs-3642	164	38	4	4	NUM
iajs-3642	164	39	4	4	NUM
iajs-3642	164	40	11	11	NUM
iajs-3642	164	41	116.40	116.40	NUM
iajs-3642	164	42	2.64	2.64	NUM
iajs-3642	164	43	2.50	2.50	NUM
iajs-3642	164	44	0.55	0.55	NUM
iajs-3642	164	45	no	no	PRON
iajs-3642	164	46	no	no	DET
iajs-3642	164	47	high	high	ADJ
iajs-3642	164	48	2e	2e	NOUN
iajs-3642	164	49	423.25	423.25	NUM
iajs-3642	164	50	4	4	NUM
iajs-3642	164	51	4	4	NUM
iajs-3642	164	52	11	11	NUM
iajs-3642	164	53	116.40	116.40	NUM
iajs-3642	164	54	2.12	2.12	NUM
iajs-3642	164	55	2.49	2.49	NUM
iajs-3642	164	56	0.55	0.55	NUM
iajs-3642	164	57	no	no	PRON
iajs-3642	164	58	no	no	DET
iajs-3642	164	59	high	high	ADJ
iajs-3642	164	60	3a	3a	NUM
iajs-3642	164	61	426.46	426.46	NUM
iajs-3642	164	62	4	4	NUM
iajs-3642	164	63	8	8	NUM
iajs-3642	164	64	11	11	NUM
iajs-3642	164	65	167.30	167.30	NUM
iajs-3642	164	66	0.65	0.65	NUM
iajs-3642	164	67	3.19	3.19	NUM
iajs-3642	164	68	0.55	0.55	NUM
iajs-3642	164	69	yes	yes	INTJ
iajs-3642	165	1	no	no	DET
iajs-3642	165	2	low	low	ADJ
iajs-3642	165	3	3b	3b	NOUN
iajs-3642	165	4	584.25	584.25	NUM
iajs-3642	165	5	4	4	NUM
iajs-3642	165	6	8	8	NUM
iajs-3642	165	7	11	11	NUM
iajs-3642	165	8	167.30	167.30	NUM
iajs-3642	165	9	0.99	0.99	NUM
iajs-3642	165	10	3.26	3.26	NUM
iajs-3642	165	11	0.55	0.55	NUM
iajs-3642	165	12	yes	yes	INTJ
iajs-3642	166	1	no	no	DET
iajs-3642	166	2	low	low	ADJ
iajs-3642	166	3	3c	3c	NUM
iajs-3642	166	4	454.52	454.52	NUM
iajs-3642	166	5	4	4	NUM
iajs-3642	166	6	8	8	NUM
iajs-3642	166	7	11	11	NUM
iajs-3642	166	8	167.30	167.30	NUM
iajs-3642	166	9	1.59	1.59	NUM
iajs-3642	166	10	3.33	3.33	NUM
iajs-3642	166	11	0.55	0.55	NUM
iajs-3642	166	12	yes	yes	INTJ
iajs-3642	166	13	no	no	DET
iajs-3642	166	14	low	low	ADJ
iajs-3642	166	15	4a	4a	NOUN
iajs-3642	167	1	326.40	326.40	NUM
iajs-3642	167	2	4	4	NUM
iajs-3642	167	3	4	4	NUM
iajs-3642	167	4	11	11	NUM
iajs-3642	167	5	82.26	82.26	NUM
iajs-3642	167	6	1.88	1.88	NUM
iajs-3642	167	7	2.48	2.48	NUM
iajs-3642	167	8	0.55	0.55	NUM
iajs-3642	167	9	no	no	PRON
iajs-3642	167	10	no	no	DET
iajs-3642	167	11	high	high	ADJ
iajs-3642	167	12	4b	4b	X
iajs-3642	167	13	416.39	416.39	NUM
iajs-3642	167	14	4	4	NUM
iajs-3642	167	15	8	8	NUM
iajs-3642	167	16	13	13	NUM
iajs-3642	167	17	173.90	173.90	NUM
iajs-3642	167	18	1.64	1.64	NUM
iajs-3642	167	19	3.00	3.00	NUM
iajs-3642	167	20	0.55	0.55	NUM
iajs-3642	167	21	yes	yes	INTJ
iajs-3642	167	22	no	no	DET
iajs-3642	167	23	low	low	ADJ
iajs-3642	167	24	4c	4c	NOUN
iajs-3642	167	25	416.39	416.39	NUM
iajs-3642	167	26	4	4	NUM
iajs-3642	167	27	8	8	NUM
iajs-3642	167	28	13	13	NUM
iajs-3642	167	29	173.90	173.90	NUM
iajs-3642	167	30	1.03	1.03	NUM
iajs-3642	167	31	2.79	2.79	NUM
iajs-3642	167	32	0.55	0.55	NUM
iajs-3642	167	33	yes	yes	INTJ
iajs-3642	167	34	no	no	PRON
iajs-3642	167	35	low	low	ADJ
iajs-3642	167	36	5	5	NUM
iajs-3642	167	37	382.42	382.42	NUM
iajs-3642	167	38	4	4	NUM
iajs-3642	167	39	6	6	NUM
iajs-3642	167	40	13	13	NUM
iajs-3642	167	41	116.40	116.40	NUM
iajs-3642	167	42	2.05	2.05	NUM
iajs-3642	167	43	2.79	2.79	NUM
iajs-3642	167	44	0.55	0.55	NUM
iajs-3642	167	45	no	no	DET
iajs-3642	167	46	no	no	ADV
iajs-3642	167	47	high	high	ADJ
iajs-3642	167	48	a	a	DET
iajs-3642	167	49	molecular	molecular	ADJ
iajs-3642	167	50	weight	weight	NOUN
iajs-3642	167	51	,	,	PUNCT
iajs-3642	167	52	b	b	X
iajs-3642	167	53	number	number	NOUN
iajs-3642	167	54	of	of	ADP
iajs-3642	167	55	hydrogen	hydrogen	NOUN
iajs-3642	167	56	bond	bond	NOUN
iajs-3642	167	57	donor	donor	NOUN
iajs-3642	167	58	,	,	PUNCT
iajs-3642	167	59	c	c	NOUN
iajs-3642	167	60	number	number	NOUN
iajs-3642	167	61	of	of	ADP
iajs-3642	167	62	hydrogen	hydrogen	NOUN
iajs-3642	167	63	bond	bond	NOUN
iajs-3642	167	64	acceptors	acceptor	NOUN
iajs-3642	167	65	,	,	PUNCT
iajs-3642	167	66	dnumber	dnumber	NOUN
iajs-3642	167	67	of	of	ADP
iajs-3642	167	68	rotatable	rotatable	ADJ
iajs-3642	167	69	bonds	bond	NOUN
iajs-3642	167	70	etopological	etopological	ADJ
iajs-3642	167	71	polar	polar	ADJ
iajs-3642	167	72	surface	surface	NOUN
iajs-3642	167	73	area	area	NOUN
iajs-3642	167	74	,	,	PUNCT
iajs-3642	167	75	f	f	PROPN
iajs-3642	167	76	logarithm	logarithm	NOUN
iajs-3642	167	77	of	of	ADP
iajs-3642	167	78	n	n	CCONJ
iajs-3642	167	79	-	-	PUNCT
iajs-3642	167	80	octanol	octanol	NOUN
iajs-3642	167	81	-	-	PUNCT
iajs-3642	167	82	water	water	NOUN
iajs-3642	167	83	partition	partition	NOUN
iajs-3642	167	84	coefficient	coefficient	NOUN
iajs-3642	167	85	,	,	PUNCT
iajs-3642	167	86	g	g	PROPN
iajs-3642	167	87	bioavailability	bioavailability	NOUN
iajs-3642	167	88	score	score	NOUN
iajs-3642	167	89	,	,	PUNCT
iajs-3642	167	90	hglyco	hglyco	ADJ
iajs-3642	167	91	protein	protein	NOUN
iajs-3642	167	92	substrate	substrate	NOUN
iajs-3642	167	93	,	,	PUNCT
iajs-3642	167	94	iblood	iblood	NOUN
iajs-3642	167	95	–	–	PUNCT
iajs-3642	167	96	brain	brain	NOUN
iajs-3642	167	97	barrier	barrier	NOUN
iajs-3642	167	98	,	,	PUNCT
iajs-3642	167	99	jgi	jgi	VERB
iajs-3642	167	100	gastrointestinal	gastrointestinal	ADJ
iajs-3642	167	101	system	system	NOUN
iajs-3642	167	102	.	.	PUNCT
iajs-3642	168	1	table	table	NOUN
iajs-3642	168	2	3	3	NUM
iajs-3642	168	3	.	.	PUNCT
iajs-3642	169	1	docking	docking	NOUN
iajs-3642	169	2	scores	score	NOUN
iajs-3642	169	3	estimated	estimate	VERB
iajs-3642	169	4	binding	bind	VERB
iajs-3642	169	5	energy	energy	NOUN
iajs-3642	169	6	(	(	PUNCT
iajs-3642	169	7	kcal	kcal	NOUN
iajs-3642	169	8	/	/	SYM
iajs-3642	169	9	mol	mol	PROPN
iajs-3642	169	10	)	)	PUNCT
iajs-3642	169	11	the	the	DET
iajs-3642	169	12	binding	bind	VERB
iajs-3642	169	13	energies	energy	NOUN
iajs-3642	169	14	for	for	ADP
iajs-3642	169	15	derivatives	derivative	NOUN
iajs-3642	169	16	and	and	CCONJ
iajs-3642	169	17	colchicine	colchicine	PROPN
iajs-3642	169	18	docked	dock	VERB
iajs-3642	169	19	with	with	ADP
iajs-3642	169	20	1sa0	1sa0	NUM
iajs-3642	169	21	.	.	PUNCT
iajs-3642	170	1	comp	comp	NOUN
iajs-3642	170	2	.	.	PUNCT
iajs-3642	171	1	number	number	NOUN
iajs-3642	171	2	binding	bind	VERB
iajs-3642	171	3	energy	energy	NOUN
iajs-3642	171	4	(	(	PUNCT
iajs-3642	171	5	plp	plp	PROPN
iajs-3642	171	6	fitness	fitness	NOUN
iajs-3642	171	7	)	)	PUNCT
iajs-3642	171	8	(	(	PUNCT
iajs-3642	171	9	kcal	kcal	NOUN
iajs-3642	171	10	/	/	SYM
iajs-3642	171	11	mol	mol	NOUN
iajs-3642	171	12	)	)	PUNCT
iajs-3642	171	13	no	no	NOUN
iajs-3642	171	14	.	.	NOUN
iajs-3642	171	15	of	of	ADP
iajs-3642	171	16	amino	amino	NOUN
iajs-3642	171	17	acids	acid	NOUN
iajs-3642	171	18	included	include	VERB
iajs-3642	171	19	in	in	ADP
iajs-3642	171	20	h	h	NOUN
iajs-3642	171	21	-	-	PUNCT
iajs-3642	171	22	bonding	bond	VERB
iajs-3642	171	23	amino	amino	NOUN
iajs-3642	171	24	acids	acid	NOUN
iajs-3642	171	25	included	include	VERB
iajs-3642	171	26	in	in	ADP
iajs-3642	171	27	h	h	NOUN
iajs-3642	171	28	-	-	PUNCT
iajs-3642	171	29	bonding	bond	VERB
iajs-3642	171	30	no	no	NOUN
iajs-3642	171	31	.	.	PUNCT
iajs-3642	171	32	of	of	ADP
iajs-3642	171	33	bonding	bonding	NOUN
iajs-3642	171	34	power	power	NOUN
iajs-3642	171	35	of	of	ADP
iajs-3642	171	36	bonding	bonding	NOUN
iajs-3642	171	37	2a	2a	NUM
iajs-3642	171	38	67.18	67.18	NUM
iajs-3642	171	39	2	2	NUM
iajs-3642	171	40	lys	lys	NOUN
iajs-3642	171	41	254	254	NUM
iajs-3642	171	42	1	1	NUM
iajs-3642	171	43	2.857	2.857	NUM
iajs-3642	171	44	asn	asn	NOUN
iajs-3642	171	45	101	101	NUM
iajs-3642	171	46	1	1	NUM
iajs-3642	171	47	2.923	2.923	NUM
iajs-3642	171	48	2b	2b	NOUN
iajs-3642	171	49	66.87	66.87	NUM
iajs-3642	171	50	1	1	NUM
iajs-3642	171	51	gln	gln	NOUN
iajs-3642	171	52	247	247	NUM
iajs-3642	171	53	1	1	NUM
iajs-3642	171	54	3.029	3.029	NUM
iajs-3642	171	55	2c	2c	NUM
iajs-3642	171	56	69.99	69.99	NUM
iajs-3642	171	57	1	1	NUM
iajs-3642	171	58	lys	lys	NOUN
iajs-3642	171	59	254	254	NUM
iajs-3642	171	60	1	1	NUM
iajs-3642	171	61	2.616	2.616	NUM
iajs-3642	171	62	2d	2d	NUM
iajs-3642	171	63	67.52	67.52	NUM
iajs-3642	171	64	2	2	NUM
iajs-3642	171	65	ser	ser	NOUN
iajs-3642	171	66	178	178	NUM
iajs-3642	171	67	1	1	NUM
iajs-3642	171	68	2.841	2.841	NUM
iajs-3642	171	69	thr	thr	NOUN
iajs-3642	171	70	179	179	NUM
iajs-3642	171	71	1	1	NUM
iajs-3642	171	72	2.736	2.736	NUM
iajs-3642	171	73	2e	2e	NOUN
iajs-3642	171	74	66.25	66.25	NUM
iajs-3642	171	75	1	1	NUM
iajs-3642	171	76	lys	lys	NOUN
iajs-3642	171	77	254	254	NUM
iajs-3642	171	78	1	1	NUM
iajs-3642	171	79	2.539	2.539	NUM
iajs-3642	171	80	ihjpas	ihjpa	NOUN
iajs-3642	171	81	.	.	PUNCT
iajs-3642	172	1	2025	2025	NUM
iajs-3642	172	2	,	,	PUNCT
iajs-3642	172	3	38	38	NUM
iajs-3642	172	4	(	(	PUNCT
iajs-3642	172	5	1	1	NUM
iajs-3642	172	6	)	)	PUNCT
iajs-3642	172	7	322	322	NUM
iajs-3642	172	8	3a	3a	NUM
iajs-3642	172	9	68.62	68.62	NUM
iajs-3642	172	10	2	2	NUM
iajs-3642	172	11	lys	lys	NOUN
iajs-3642	172	12	254	254	NUM
iajs-3642	172	13	1	1	NUM
iajs-3642	172	14	2.812	2.812	NUM
iajs-3642	172	15	asn	asn	NOUN
iajs-3642	172	16	101	101	NUM
iajs-3642	172	17	1	1	NUM
iajs-3642	172	18	2.760	2.760	NUM
iajs-3642	172	19	3c	3c	NUM
iajs-3642	172	20	67.07	67.07	NUM
iajs-3642	172	21	2	2	NUM
iajs-3642	172	22	asn	asn	NOUN
iajs-3642	172	23	101	101	NUM
iajs-3642	172	24	2	2	NUM
iajs-3642	172	25	2.914	2.914	NUM
iajs-3642	172	26	2.911	2.911	NUM
iajs-3642	172	27	tyr	tyr	PROPN
iajs-3642	172	28	224	224	NUM
iajs-3642	172	29	1	1	NUM
iajs-3642	172	30	2.986	2.986	NUM
iajs-3642	172	31	4a	4a	NOUN
iajs-3642	172	32	67.40	67.40	NUM
iajs-3642	172	33	2	2	NUM
iajs-3642	172	34	asn	asn	NOUN
iajs-3642	172	35	101	101	NUM
iajs-3642	172	36	1	1	NUM
iajs-3642	172	37	2.815	2.815	NUM
iajs-3642	172	38	gln	gln	NOUN
iajs-3642	172	39	11	11	NUM
iajs-3642	172	40	1	1	NUM
iajs-3642	172	41	2.944	2.944	NUM
iajs-3642	172	42	4b	4b	X
iajs-3642	172	43	69.57	69.57	NUM
iajs-3642	172	44	2	2	NUM
iajs-3642	172	45	gly	gly	NOUN
iajs-3642	172	46	144	144	NUM
iajs-3642	172	47	1	1	NUM
iajs-3642	172	48	2.984	2.984	NUM
iajs-3642	172	49	lys	lys	NOUN
iajs-3642	172	50	254	254	NUM
iajs-3642	172	51	1	1	NUM
iajs-3642	172	52	2.796	2.796	NUM
iajs-3642	172	53	4c	4c	NOUN
iajs-3642	172	54	65.05	65.05	NUM
iajs-3642	172	55	3	3	NUM
iajs-3642	172	56	tyr	tyr	NOUN
iajs-3642	172	57	224	224	NUM
iajs-3642	172	58	1	1	NUM
iajs-3642	172	59	2.910	2.910	NUM
iajs-3642	172	60	lys	lys	NOUN
iajs-3642	172	61	254	254	NUM
iajs-3642	172	62	1	1	NUM
iajs-3642	172	63	3.065	3.065	NUM
iajs-3642	172	64	thr	thr	NOUN
iajs-3642	172	65	179	179	NUM
iajs-3642	172	66	1	1	NUM
iajs-3642	172	67	3.023	3.023	NUM
iajs-3642	172	68	5	5	NUM
iajs-3642	172	69	71.77	71.77	NUM
iajs-3642	172	70	1	1	NUM
iajs-3642	172	71	lys	lys	NOUN
iajs-3642	172	72	254	254	NUM
iajs-3642	172	73	1	1	NUM
iajs-3642	172	74	2.825	2.825	NUM
iajs-3642	172	75	colchicine	colchicine	PROPN
iajs-3642	172	76	52.44	52.44	NUM
iajs-3642	172	77	3	3	NUM
iajs-3642	172	78	asn	asn	PROPN
iajs-3642	172	79	101	101	NUM
iajs-3642	172	80	1	1	NUM
iajs-3642	172	81	2.733	2.733	NUM
iajs-3642	172	82	lys	lys	NOUN
iajs-3642	172	83	254	254	NUM
iajs-3642	172	84	1	1	NUM
iajs-3642	172	85	2.989	2.989	NUM
iajs-3642	172	86	ser	ser	NOUN
iajs-3642	172	87	178	178	NUM
iajs-3642	172	88	1	1	NUM
iajs-3642	172	89	2.928	2.928	NUM
iajs-3642	172	90	figure	figure	NOUN
iajs-3642	172	91	1	1	NUM
iajs-3642	172	92	.	.	PUNCT
iajs-3642	172	93	interactions	interaction	NOUN
iajs-3642	172	94	between	between	ADP
iajs-3642	172	95	target	target	NOUN
iajs-3642	172	96	protein	protein	NOUN
iajs-3642	172	97	residues	residue	NOUN
iajs-3642	172	98	and	and	CCONJ
iajs-3642	172	99	various	various	ADJ
iajs-3642	172	100	ligands	ligand	NOUN
iajs-3642	172	101	:	:	PUNCT
iajs-3642	172	102	ligands	ligand	NOUN
iajs-3642	172	103	are	be	AUX
iajs-3642	172	104	shown	show	VERB
iajs-3642	172	105	as	as	ADP
iajs-3642	172	106	ball	ball	NOUN
iajs-3642	172	107	and	and	CCONJ
iajs-3642	172	108	stick	stick	PROPN
iajs-3642	172	109	shapes	shape	NOUN
iajs-3642	172	110	,	,	PUNCT
iajs-3642	172	111	with	with	ADP
iajs-3642	172	112	green	green	ADJ
iajs-3642	172	113	,	,	PUNCT
iajs-3642	172	114	blue	blue	ADJ
iajs-3642	172	115	,	,	PUNCT
iajs-3642	172	116	red	red	ADJ
iajs-3642	172	117	,	,	PUNCT
iajs-3642	172	118	and	and	CCONJ
iajs-3642	172	119	yellow	yellow	ADJ
iajs-3642	172	120	representing	represent	VERB
iajs-3642	172	121	carbon	carbon	NOUN
iajs-3642	172	122	,	,	PUNCT
iajs-3642	172	123	nitrogen	nitrogen	NOUN
iajs-3642	172	124	,	,	PUNCT
iajs-3642	172	125	oxygen	oxygen	NOUN
iajs-3642	172	126	,	,	PUNCT
iajs-3642	172	127	and	and	CCONJ
iajs-3642	172	128	sulfur	sulfur	NOUN
iajs-3642	172	129	atoms	atom	NOUN
iajs-3642	172	130	,	,	PUNCT
iajs-3642	172	131	respectively	respectively	ADV
iajs-3642	172	132	.	.	PUNCT
iajs-3642	173	1	side	side	NOUN
iajs-3642	173	2	chain	chain	NOUN
iajs-3642	173	3	residues	residue	NOUN
iajs-3642	173	4	are	be	AUX
iajs-3642	173	5	shown	show	VERB
iajs-3642	173	6	as	as	ADP
iajs-3642	173	7	sticks	stick	NOUN
iajs-3642	173	8	,	,	PUNCT
iajs-3642	173	9	with	with	ADP
iajs-3642	173	10	gray	gray	ADJ
iajs-3642	173	11	,	,	PUNCT
iajs-3642	173	12	blue	blue	ADJ
iajs-3642	173	13	,	,	PUNCT
iajs-3642	173	14	and	and	CCONJ
iajs-3642	173	15	red	red	ADJ
iajs-3642	173	16	representing	represent	VERB
iajs-3642	173	17	carbon	carbon	NOUN
iajs-3642	173	18	,	,	PUNCT
iajs-3642	173	19	nitrogen	nitrogen	NOUN
iajs-3642	173	20	,	,	PUNCT
iajs-3642	173	21	and	and	CCONJ
iajs-3642	173	22	oxygen	oxygen	NOUN
iajs-3642	173	23	atoms	atom	NOUN
iajs-3642	173	24	,	,	PUNCT
iajs-3642	173	25	sequentially	sequentially	ADV
iajs-3642	173	26	.	.	PUNCT
iajs-3642	174	1	colchicine	colchicine	PROPN
iajs-3642	174	2	2a	2a	PROPN
iajs-3642	174	3	2b	2b	NUM
iajs-3642	174	4	2c	2c	NUM
iajs-3642	174	5	2d	2d	NOUN
iajs-3642	174	6	2e	2e	PROPN
iajs-3642	174	7	3a	3a	NUM
iajs-3642	174	8	3c	3c	NUM
iajs-3642	174	9	4a	4a	NOUN
iajs-3642	174	10	4b	4b	PROPN
iajs-3642	174	11	4c	4c	PROPN
iajs-3642	174	12	5	5	NUM
iajs-3642	174	13	ihjpas	ihjpa	NOUN
iajs-3642	174	14	.	.	PUNCT
iajs-3642	175	1	2025	2025	NUM
iajs-3642	175	2	,	,	PUNCT
iajs-3642	175	3	38	38	NUM
iajs-3642	175	4	(	(	PUNCT
iajs-3642	175	5	1	1	NUM
iajs-3642	175	6	)	)	PUNCT
iajs-3642	175	7	323	323	NUM
iajs-3642	175	8	4	4	NUM
iajs-3642	175	9	.	.	PUNCT
iajs-3642	175	10	conclusion	conclusion	VERB
iajs-3642	175	11	the	the	DET
iajs-3642	175	12	purpose	purpose	NOUN
iajs-3642	175	13	of	of	ADP
iajs-3642	175	14	the	the	DET
iajs-3642	175	15	current	current	ADJ
iajs-3642	175	16	study	study	NOUN
iajs-3642	175	17	was	be	AUX
iajs-3642	175	18	to	to	PART
iajs-3642	175	19	prepare	prepare	VERB
iajs-3642	175	20	a	a	DET
iajs-3642	175	21	series	series	NOUN
iajs-3642	175	22	of	of	ADP
iajs-3642	175	23	different	different	ADJ
iajs-3642	175	24	derivatives	derivative	NOUN
iajs-3642	175	25	(	(	PUNCT
iajs-3642	175	26	1–5	1–5	X
iajs-3642	175	27	)	)	PUNCT
iajs-3642	175	28	derived	derive	VERB
iajs-3642	175	29	from	from	ADP
iajs-3642	175	30	benzoyl	benzoyl	PROPN
iajs-3642	175	31	chloride	chloride	NOUN
iajs-3642	175	32	,	,	PUNCT
iajs-3642	175	33	benzyl	benzyl	NOUN
iajs-3642	175	34	chloride	chloride	NOUN
iajs-3642	175	35	,	,	PUNCT
iajs-3642	175	36	sulphonyl	sulphonyl	NOUN
iajs-3642	175	37	chloride	chloride	NOUN
iajs-3642	175	38	,	,	PUNCT
iajs-3642	175	39	and	and	CCONJ
iajs-3642	175	40	phenacyl	phenacyl	VERB
iajs-3642	175	41	chloride	chloride	NOUN
iajs-3642	175	42	.	.	PUNCT
iajs-3642	176	1	after	after	ADP
iajs-3642	176	2	that	that	DET
iajs-3642	176	3	study	study	NOUN
iajs-3642	176	4	,	,	PUNCT
iajs-3642	176	5	molecular	molecular	ADJ
iajs-3642	176	6	docking	docking	NOUN
iajs-3642	176	7	and	and	CCONJ
iajs-3642	176	8	adme	adme	NOUN
iajs-3642	176	9	were	be	AUX
iajs-3642	176	10	supported	support	VERB
iajs-3642	176	11	by	by	ADP
iajs-3642	176	12	a	a	DET
iajs-3642	176	13	boiled	boil	VERB
iajs-3642	176	14	egg	egg	NOUN
iajs-3642	176	15	study	study	NOUN
iajs-3642	176	16	with	with	ADP
iajs-3642	176	17	product	product	NOUN
iajs-3642	176	18	yields	yield	NOUN
iajs-3642	176	19	ranging	range	VERB
iajs-3642	176	20	from	from	ADP
iajs-3642	176	21	58	58	NUM
iajs-3642	176	22	to	to	PART
iajs-3642	176	23	88	88	NUM
iajs-3642	176	24	%	%	NOUN
iajs-3642	176	25	,	,	PUNCT
iajs-3642	176	26	and	and	CCONJ
iajs-3642	176	27	all	all	PRON
iajs-3642	176	28	of	of	ADP
iajs-3642	176	29	the	the	DET
iajs-3642	176	30	prepared	prepare	VERB
iajs-3642	176	31	derivatives	derivative	NOUN
iajs-3642	176	32	were	be	AUX
iajs-3642	176	33	proved	prove	VERB
iajs-3642	176	34	by	by	ADP
iajs-3642	176	35	ft	ft	PROPN
iajs-3642	176	36	-	-	PUNCT
iajs-3642	176	37	ir	ir	PROPN
iajs-3642	176	38	,	,	PUNCT
iajs-3642	176	39	1h	1h	NUM
iajs-3642	176	40	nmr	nmr	NOUN
iajs-3642	176	41	,	,	PUNCT
iajs-3642	176	42	and	and	CCONJ
iajs-3642	176	43	13	13	NUM
iajs-3642	176	44	cnmr	cnmr	NOUN
iajs-3642	176	45	spectra	spectra	NOUN
iajs-3642	176	46	.	.	PUNCT
iajs-3642	177	1	among	among	ADP
iajs-3642	177	2	the	the	DET
iajs-3642	177	3	prepared	prepare	VERB
iajs-3642	177	4	compounds	compound	NOUN
iajs-3642	177	5	,	,	PUNCT
iajs-3642	177	6	according	accord	VERB
iajs-3642	177	7	to	to	ADP
iajs-3642	177	8	molecular	molecular	ADJ
iajs-3642	177	9	docking	docking	NOUN
iajs-3642	177	10	studies	study	NOUN
iajs-3642	177	11	,	,	PUNCT
iajs-3642	177	12	all	all	DET
iajs-3642	177	13	synthesized	synthesize	VERB
iajs-3642	177	14	compounds	compound	NOUN
iajs-3642	177	15	gave	give	VERB
iajs-3642	177	16	excellent	excellent	ADJ
iajs-3642	177	17	results	result	NOUN
iajs-3642	177	18	by	by	ADP
iajs-3642	177	19	showing	show	VERB
iajs-3642	177	20	the	the	DET
iajs-3642	177	21	best	good	ADJ
iajs-3642	177	22	bonding	bonding	NOUN
iajs-3642	177	23	into	into	ADP
iajs-3642	177	24	the	the	DET
iajs-3642	177	25	active	active	ADJ
iajs-3642	177	26	site	site	NOUN
iajs-3642	177	27	of	of	ADP
iajs-3642	177	28	1sa0	1sa0	NUM
iajs-3642	177	29	protein	protein	NOUN
iajs-3642	177	30	,	,	PUNCT
iajs-3642	177	31	which	which	PRON
iajs-3642	177	32	candidate	candidate	VERB
iajs-3642	177	33	it	it	PRON
iajs-3642	177	34	to	to	PART
iajs-3642	177	35	be	be	AUX
iajs-3642	177	36	good	good	ADJ
iajs-3642	177	37	anti	anti	ADJ
iajs-3642	177	38	-	-	ADJ
iajs-3642	177	39	bacterial	bacterial	ADJ
iajs-3642	177	40	against	against	ADP
iajs-3642	177	41	escherichia	escherichia	NOUN
iajs-3642	177	42	coli	coli	NOUN
iajs-3642	177	43	and	and	CCONJ
iajs-3642	177	44	anti	anti	ADJ
iajs-3642	177	45	-	-	ADJ
iajs-3642	177	46	breast	breast	ADJ
iajs-3642	177	47	cancer	cancer	NOUN
iajs-3642	177	48	so	so	SCONJ
iajs-3642	177	49	that	that	SCONJ
iajs-3642	177	50	all	all	DET
iajs-3642	177	51	synthesis	synthesis	NOUN
iajs-3642	177	52	compounds	compound	NOUN
iajs-3642	177	53	give	give	VERB
iajs-3642	177	54	excellent	excellent	ADJ
iajs-3642	177	55	results	result	NOUN
iajs-3642	177	56	by	by	ADP
iajs-3642	177	57	showing	show	VERB
iajs-3642	177	58	the	the	DET
iajs-3642	177	59	best	good	ADJ
iajs-3642	177	60	bonding	bonding	NOUN
iajs-3642	177	61	(	(	PUNCT
iajs-3642	177	62	theoretically	theoretically	ADV
iajs-3642	177	63	)	)	PUNCT
iajs-3642	177	64	in	in	ADP
iajs-3642	177	65	the	the	DET
iajs-3642	177	66	active	active	ADJ
iajs-3642	177	67	site	site	NOUN
iajs-3642	177	68	of	of	ADP
iajs-3642	177	69	the	the	DET
iajs-3642	177	70	1sa0	1sa0	NUM
iajs-3642	177	71	protein	protein	NOUN
iajs-3642	177	72	,	,	PUNCT
iajs-3642	177	73	compared	compare	VERB
iajs-3642	177	74	to	to	ADP
iajs-3642	177	75	colchicine	colchicine	PROPN
iajs-3642	177	76	drug	drug	NOUN
iajs-3642	177	77	.	.	PUNCT
iajs-3642	178	1	one	one	NUM
iajs-3642	178	2	of	of	ADP
iajs-3642	178	3	the	the	DET
iajs-3642	178	4	more	more	ADV
iajs-3642	178	5	significant	significant	ADJ
iajs-3642	178	6	findings	finding	NOUN
iajs-3642	178	7	to	to	PART
iajs-3642	178	8	emerge	emerge	VERB
iajs-3642	178	9	from	from	ADP
iajs-3642	178	10	this	this	DET
iajs-3642	178	11	study	study	NOUN
iajs-3642	178	12	is	be	AUX
iajs-3642	178	13	that	that	SCONJ
iajs-3642	178	14	the	the	DET
iajs-3642	178	15	2b	2b	NUM
iajs-3642	178	16	derivative	derivative	ADJ
iajs-3642	178	17	exhibits	exhibit	NOUN
iajs-3642	178	18	the	the	DET
iajs-3642	178	19	most	most	ADV
iajs-3642	178	20	excellent	excellent	ADJ
iajs-3642	178	21	absorption	absorption	NOUN
iajs-3642	178	22	in	in	ADP
iajs-3642	178	23	gi	gi	NOUN
iajs-3642	178	24	and	and	CCONJ
iajs-3642	178	25	has	have	VERB
iajs-3642	178	26	a	a	DET
iajs-3642	178	27	good	good	ADJ
iajs-3642	178	28	bonding	bonding	NOUN
iajs-3642	178	29	with	with	ADP
iajs-3642	178	30	the	the	DET
iajs-3642	178	31	active	active	ADJ
iajs-3642	178	32	site	site	NOUN
iajs-3642	178	33	of	of	ADP
iajs-3642	178	34	the	the	DET
iajs-3642	178	35	protein	protein	NOUN
iajs-3642	178	36	more	more	ADJ
iajs-3642	178	37	than	than	ADP
iajs-3642	178	38	the	the	DET
iajs-3642	178	39	colchicine	colchicine	PROPN
iajs-3642	178	40	drug	drug	NOUN
iajs-3642	178	41	,	,	PUNCT
iajs-3642	178	42	and	and	CCONJ
iajs-3642	178	43	derivative	derivative	ADJ
iajs-3642	178	44	5	5	NUM
iajs-3642	178	45	has	have	VERB
iajs-3642	178	46	the	the	DET
iajs-3642	178	47	highest	high	ADJ
iajs-3642	178	48	bonding	bonding	NOUN
iajs-3642	178	49	into	into	ADP
iajs-3642	178	50	the	the	DET
iajs-3642	178	51	active	active	ADJ
iajs-3642	178	52	site	site	NOUN
iajs-3642	178	53	of	of	ADP
iajs-3642	178	54	1sa0	1sa0	NUM
iajs-3642	178	55	protein	protein	NOUN
iajs-3642	178	56	more	more	ADJ
iajs-3642	178	57	than	than	ADP
iajs-3642	178	58	colchicine	colchicine	NOUN
iajs-3642	178	59	drug	drug	NOUN
iajs-3642	178	60	.	.	PUNCT
iajs-3642	179	1	still	still	ADV
iajs-3642	179	2	,	,	PUNCT
iajs-3642	179	3	it	it	PRON
iajs-3642	179	4	ca	can	AUX
iajs-3642	179	5	n’t	not	PART
iajs-3642	179	6	penetrate	penetrate	VERB
iajs-3642	179	7	the	the	DET
iajs-3642	179	8	(	(	PUNCT
iajs-3642	179	9	cns	cns	NOUN
iajs-3642	179	10	)	)	PUNCT
iajs-3642	179	11	.	.	PUNCT
iajs-3642	180	1	acknowledgment	acknowledgment	NOUN
iajs-3642	180	2	the	the	DET
iajs-3642	180	3	authors	author	NOUN
iajs-3642	180	4	thank	thank	VERB
iajs-3642	180	5	the	the	DET
iajs-3642	180	6	department	department	NOUN
iajs-3642	180	7	of	of	ADP
iajs-3642	180	8	chemistry	chemistry	NOUN
iajs-3642	180	9	,	,	PUNCT
iajs-3642	180	10	college	college	NOUN
iajs-3642	180	11	of	of	ADP
iajs-3642	180	12	sciences	science	NOUN
iajs-3642	180	13	,	,	PUNCT
iajs-3642	180	14	university	university	NOUN
iajs-3642	180	15	of	of	ADP
iajs-3642	180	16	baghdad	baghdad	PROPN
iajs-3642	180	17	,	,	PUNCT
iajs-3642	180	18	for	for	ADP
iajs-3642	180	19	providing	provide	VERB
iajs-3642	180	20	chemicals	chemical	NOUN
iajs-3642	180	21	and	and	CCONJ
iajs-3642	180	22	support	support	NOUN
iajs-3642	180	23	.	.	PUNCT
iajs-3642	181	1	conflict	conflict	NOUN
iajs-3642	181	2	of	of	ADP
iajs-3642	181	3	interest	interest	NOUN
iajs-3642	181	4	the	the	DET
iajs-3642	181	5	authors	author	NOUN
iajs-3642	181	6	declare	declare	VERB
iajs-3642	181	7	that	that	SCONJ
iajs-3642	181	8	they	they	PRON
iajs-3642	181	9	have	have	VERB
iajs-3642	181	10	no	no	DET
iajs-3642	181	11	conflicts	conflict	NOUN
iajs-3642	181	12	of	of	ADP
iajs-3642	181	13	interest	interest	NOUN
iajs-3642	181	14	.	.	PUNCT
iajs-3642	182	1	funding	fund	VERB
iajs-3642	182	2	no	no	DET
iajs-3642	182	3	founding	founding	NOUN
iajs-3642	182	4	.	.	PUNCT
iajs-3642	183	1	ethical	ethical	ADJ
iajs-3642	183	2	clearance	clearance	NOUN
iajs-3642	183	3	this	this	DET
iajs-3642	183	4	work	work	NOUN
iajs-3642	183	5	has	have	AUX
iajs-3642	183	6	been	be	AUX
iajs-3642	183	7	approved	approve	VERB
iajs-3642	183	8	by	by	ADP
iajs-3642	183	9	the	the	DET
iajs-3642	183	10	scientific	scientific	ADJ
iajs-3642	183	11	committee	committee	NOUN
iajs-3642	183	12	at	at	ADP
iajs-3642	183	13	the	the	DET
iajs-3642	183	14	university	university	NOUN
iajs-3642	183	15	of	of	ADP
iajs-3642	183	16	baghdad/	baghdad/	NUM
iajs-3642	183	17	college	college	NOUN
iajs-3642	183	18	of	of	ADP
iajs-3642	183	19	sciences	science	NOUN
iajs-3642	183	20	,	,	PUNCT
iajs-3642	183	21	department	department	NOUN
iajs-3642	183	22	of	of	ADP
iajs-3642	183	23	chemistry	chemistry	NOUN
iajs-3642	183	24	.	.	PUNCT
iajs-3642	184	1	references	reference	NOUN
iajs-3642	184	2	1	1	NUM
iajs-3642	184	3	.	.	PUNCT
iajs-3642	184	4	bhattacharyya	bhattacharyya	PROPN
iajs-3642	184	5	b	b	PROPN
iajs-3642	184	6	,	,	PUNCT
iajs-3642	184	7	panda	panda	NOUN
iajs-3642	184	8	d	d	PROPN
iajs-3642	184	9	,	,	PUNCT
iajs-3642	184	10	gupta	gupta	PROPN
iajs-3642	184	11	s	s	PART
iajs-3642	184	12	,	,	PUNCT
iajs-3642	184	13	banerjee	banerjee	PROPN
iajs-3642	184	14	m.	m.	NOUN
iajs-3642	184	15	anti	anti	ADJ
iajs-3642	184	16	-	-	ADJ
iajs-3642	184	17	mitotic	mitotic	ADJ
iajs-3642	184	18	activity	activity	NOUN
iajs-3642	184	19	of	of	ADP
iajs-3642	184	20	colchicine	colchicine	PROPN
iajs-3642	184	21	and	and	CCONJ
iajs-3642	184	22	the	the	DET
iajs-3642	184	23	structural	structural	ADJ
iajs-3642	184	24	basis	basis	NOUN
iajs-3642	184	25	for	for	ADP
iajs-3642	184	26	its	its	PRON
iajs-3642	184	27	interaction	interaction	NOUN
iajs-3642	184	28	with	with	ADP
iajs-3642	184	29	tubulin	tubulin	NOUN
iajs-3642	184	30	.	.	PUNCT
iajs-3642	185	1	med	med	PROPN
iajs-3642	185	2	res	re	NOUN
iajs-3642	185	3	rev	rev	PROPN
iajs-3642	185	4	.	.	PROPN
iajs-3642	185	5	2008	2008	NUM
iajs-3642	185	6	;	;	PUNCT
iajs-3642	185	7	28(1):155–183	28(1):155–183	NUM
iajs-3642	185	8	.	.	PUNCT
iajs-3642	186	1	https://doi.org/10.1002/med.20097	https://doi.org/10.1002/med.20097	NOUN
iajs-3642	186	2	.	.	NOUN
iajs-3642	187	1	2	2	NUM
iajs-3642	187	2	.	.	X
iajs-3642	187	3	ravelli	ravelli	PROPN
iajs-3642	187	4	rb	rb	PROPN
iajs-3642	187	5	,	,	PUNCT
iajs-3642	187	6	gigant	gigant	NOUN
iajs-3642	187	7	b	b	NOUN
iajs-3642	187	8	,	,	PUNCT
iajs-3642	187	9	curmi	curmi	NOUN
iajs-3642	187	10	p	p	PROPN
iajs-3642	187	11	a	a	PROPN
iajs-3642	187	12	,	,	PUNCT
iajs-3642	187	13	jourdain	jourdain	NOUN
iajs-3642	188	1	i	i	PRON
iajs-3642	188	2	,	,	PUNCT
iajs-3642	188	3	lachkar	lachkar	PROPN
iajs-3642	188	4	s	s	PROPN
iajs-3642	188	5	,	,	PUNCT
iajs-3642	188	6	sobel	sobel	PROPN
iajs-3642	188	7	,	,	PUNCT
iajs-3642	188	8	a	a	DET
iajs-3642	188	9	,	,	PUNCT
iajs-3642	188	10	knossowm	knossowm	NOUN
iajs-3642	188	11	.	.	PUNCT
iajs-3642	189	1	insight	insight	NOUN
iajs-3642	189	2	into	into	ADP
iajs-3642	189	3	tubulin	tubulin	NOUN
iajs-3642	189	4	regulation	regulation	NOUN
iajs-3642	189	5	from	from	ADP
iajs-3642	189	6	a	a	DET
iajs-3642	189	7	complex	complex	NOUN
iajs-3642	189	8	with	with	ADP
iajs-3642	189	9	colchicine	colchicine	NOUN
iajs-3642	189	10	and	and	CCONJ
iajs-3642	189	11	a	a	DET
iajs-3642	189	12	stathmin	stathmin	VERB
iajs-3642	189	13	-	-	PUNCT
iajs-3642	189	14	like	like	ADJ
iajs-3642	189	15	domain	domain	NOUN
iajs-3642	189	16	.	.	PUNCT
iajs-3642	190	1	nature	nature	NOUN
iajs-3642	190	2	.	.	PUNCT
iajs-3642	191	1	2004	2004	NUM
iajs-3642	191	2	;	;	PUNCT
iajs-3642	192	1	428(6979):198202	428(6979):198202	PROPN
iajs-3642	192	2	.	.	PUNCT
iajs-3642	193	1	http://dx.doi.org/10.1038/nature02393	http://dx.doi.org/10.1038/nature02393	PROPN
iajs-3642	193	2	.	.	PUNCT
iajs-3642	194	1	3	3	X
iajs-3642	194	2	.	.	X
iajs-3642	194	3	wang	wang	PROPN
iajs-3642	194	4	g	g	PROPN
iajs-3642	194	5	,	,	PUNCT
iajs-3642	194	6	liu	liu	PROPN
iajs-3642	194	7	w	w	PROPN
iajs-3642	194	8	,	,	PUNCT
iajs-3642	194	9	gong	gong	PROPN
iajs-3642	194	10	z	z	PROPN
iajs-3642	194	11	,	,	PUNCT
iajs-3642	194	12	huang	huang	PROPN
iajs-3642	194	13	y	y	PROPN
iajs-3642	194	14	,	,	PUNCT
iajs-3642	194	15	li	li	PROPN
iajs-3642	194	16	y	y	PROPN
iajs-3642	194	17	,	,	PUNCT
iajs-3642	194	18	peng	peng	PROPN
iajs-3642	194	19	z.	z.	PROPN
iajs-3642	194	20	synthesis	synthesis	PROPN
iajs-3642	194	21	,	,	PUNCT
iajs-3642	194	22	biological	biological	ADJ
iajs-3642	194	23	evaluation	evaluation	NOUN
iajs-3642	194	24	,	,	PUNCT
iajs-3642	194	25	and	and	CCONJ
iajs-3642	194	26	molecular	molecular	ADJ
iajs-3642	194	27	modelling	modelling	NOUN
iajs-3642	194	28	of	of	ADP
iajs-3642	194	29	new	new	ADJ
iajs-3642	194	30	naphthalene	naphthalene	NOUN
iajs-3642	194	31	-	-	PUNCT
iajs-3642	194	32	chalcone	chalcone	NOUN
iajs-3642	194	33	derivatives	derivative	NOUN
iajs-3642	194	34	as	as	ADP
iajs-3642	194	35	potential	potential	ADJ
iajs-3642	194	36	anticancer	anticancer	NOUN
iajs-3642	194	37	agents	agent	NOUN
iajs-3642	194	38	on	on	ADP
iajs-3642	194	39	mcf-7	mcf-7	VERB
iajs-3642	194	40	breast	breast	NOUN
iajs-3642	194	41	cancer	cancer	NOUN
iajs-3642	194	42	cells	cell	NOUN
iajs-3642	194	43	by	by	ADP
iajs-3642	194	44	targeting	target	VERB
iajs-3642	194	45	tubulin	tubulin	NOUN
iajs-3642	194	46	colchicine	colchicine	NOUN
iajs-3642	194	47	binding	bind	VERB
iajs-3642	194	48	site	site	NOUN
iajs-3642	194	49	.	.	PUNCT
iajs-3642	195	1	jeimc	jeimc	PROPN
iajs-3642	195	2	.	.	PUNCT
iajs-3642	196	1	2020	2020	NUM
iajs-3642	196	2	;	;	PUNCT
iajs-3642	196	3	35(1):139	35(1):139	NOUN
iajs-3642	196	4	-	-	SYM
iajs-3642	196	5	144	144	NUM
iajs-3642	196	6	.	.	PUNCT
iajs-3642	196	7	https://doi.org/10.1080/14756366.2019.1690479	https://doi.org/10.1080/14756366.2019.1690479	X
iajs-3642	196	8	.	.	PUNCT
iajs-3642	197	1	4	4	X
iajs-3642	197	2	.	.	X
iajs-3642	197	3	wang	wang	PROPN
iajs-3642	197	4	g	g	PROPN
iajs-3642	197	5	,	,	PUNCT
iajs-3642	197	6	peng	peng	PROPN
iajs-3642	197	7	z	z	PROPN
iajs-3642	197	8	,	,	PUNCT
iajs-3642	197	9	zhang	zhang	PROPN
iajs-3642	197	10	j	j	PROPN
iajs-3642	197	11	,	,	PUNCT
iajs-3642	197	12	qiu	qiu	PROPN
iajs-3642	197	13	j	j	PROPN
iajs-3642	197	14	,	,	PUNCT
iajs-3642	197	15	xie	xie	PROPN
iajs-3642	198	1	z	z	PROPN
iajs-3642	198	2	,	,	PUNCT
iajs-3642	198	3	gong	gong	PROPN
iajs-3642	198	4	z.	z.	PROPN
iajs-3642	198	5	synthesis	synthesis	PROPN
iajs-3642	198	6	,	,	PUNCT
iajs-3642	198	7	biological	biological	ADJ
iajs-3642	198	8	evaluation	evaluation	NOUN
iajs-3642	198	9	and	and	CCONJ
iajs-3642	198	10	molecular	molecular	ADJ
iajs-3642	198	11	docking	docking	NOUN
iajs-3642	198	12	studies	study	NOUN
iajs-3642	198	13	of	of	ADP
iajs-3642	198	14	aminochalcone	aminochalcone	NOUN
iajs-3642	198	15	derivatives	derivative	NOUN
iajs-3642	198	16	as	as	ADP
iajs-3642	198	17	potential	potential	ADJ
iajs-3642	198	18	anticancer	anticancer	NOUN
iajs-3642	198	19	agents	agent	NOUN
iajs-3642	198	20	by	by	ADP
iajs-3642	198	21	targeting	target	VERB
iajs-3642	198	22	tubulin	tubulin	NOUN
iajs-3642	198	23	https://doi.org/10.1002/med.20097	https://doi.org/10.1002/med.20097	PROPN
iajs-3642	198	24	http://dx.doi.org/10.1038/nature02393	http://dx.doi.org/10.1038/nature02393	PROPN
iajs-3642	198	25	https://doi.org/10.1080/14756366.2019.1690479	https://doi.org/10.1080/14756366.2019.1690479	PUNCT
iajs-3642	198	26	ihjpas	ihjpas	PROPN
iajs-3642	198	27	.	.	PUNCT
iajs-3642	199	1	2025	2025	NUM
iajs-3642	199	2	,	,	PUNCT
iajs-3642	199	3	38	38	NUM
iajs-3642	199	4	(	(	PUNCT
iajs-3642	199	5	1	1	NUM
iajs-3642	199	6	)	)	PUNCT
iajs-3642	199	7	324	324	NUM
iajs-3642	199	8	colchicine	colchicine	NOUN
iajs-3642	199	9	binding	bind	VERB
iajs-3642	199	10	site.bioorg	site.bioorg	ADJ
iajs-3642	199	11	chem	chem	NOUN
iajs-3642	199	12	.	.	PUNCT
iajs-3642	200	1	2018	2018	NUM
iajs-3642	200	2	;	;	PUNCT
iajs-3642	201	1	78(8):332	78(8):332	X
iajs-3642	201	2	-	-	SYM
iajs-3642	201	3	340	340	NUM
iajs-3642	201	4	.	.	PUNCT
iajs-3642	202	1	https://doi.org/10.1016/j.bioorg.2018.03.028	https://doi.org/10.1016/j.bioorg.2018.03.028	NOUN
iajs-3642	202	2	.	.	PUNCT
iajs-3642	203	1	5	5	NUM
iajs-3642	203	2	.	.	PUNCT
iajs-3642	203	3	li	li	PROPN
iajs-3642	203	4	l	l	PROPN
iajs-3642	203	5	,	,	PUNCT
iajs-3642	203	6	jiang	jiang	PROPN
iajs-3642	203	7	s.	s.	PROPN
iajs-3642	203	8	li	li	PROPN
iajs-3642	204	1	x	x	PROPN
iajs-3642	204	2	,	,	PUNCT
iajs-3642	204	3	liu	liu	PROPN
iajs-3642	204	4	y	y	PROPN
iajs-3642	204	5	,	,	PUNCT
iajs-3642	204	6	su	su	PROPN
iajs-3642	204	7	j	j	PROPN
iajs-3642	204	8	,	,	PUNCT
iajs-3642	204	9	chen	chen	PROPN
iajs-3642	204	10	j.	j.	PROPN
iajs-3642	204	11	recent	recent	PROPN
iajs-3642	204	12	advances	advance	NOUN
iajs-3642	204	13	in	in	ADP
iajs-3642	204	14	trimethoxyphenyl	trimethoxyphenyl	NOUN
iajs-3642	204	15	(	(	PUNCT
iajs-3642	204	16	tmp	tmp	NOUN
iajs-3642	204	17	)	)	PUNCT
iajs-3642	204	18	based	base	VERB
iajs-3642	204	19	tubulin	tubulin	NOUN
iajs-3642	204	20	inhibitors	inhibitor	NOUN
iajs-3642	204	21	targeting	target	VERB
iajs-3642	204	22	the	the	DET
iajs-3642	204	23	colchicine	colchicine	NOUN
iajs-3642	204	24	binding	bind	VERB
iajs-3642	204	25	site	site	NOUN
iajs-3642	204	26	.	.	PUNCT
iajs-3642	205	1	ejmech	ejmech	PROPN
iajs-3642	205	2	.	.	PUNCT
iajs-3642	206	1	2018;151:482	2018;151:482	NUM
iajs-3642	206	2	-	-	SYM
iajs-3642	206	3	494	494	NUM
iajs-3642	206	4	.	.	PUNCT
iajs-3642	207	1	https://doi.org/10.1016/j.ejmech.2018.04.011	https://doi.org/10.1016/j.ejmech.2018.04.011	X
iajs-3642	207	2	.	.	PUNCT
iajs-3642	208	1	6	6	NUM
iajs-3642	208	2	.	.	X
iajs-3642	208	3	luis	luis	PROPN
iajs-3642	208	4	l	l	PROPN
iajs-3642	208	5	,	,	PUNCT
iajs-3642	208	6	serrano	serrano	PROPN
iajs-3642	208	7	ml	ml	PROPN
iajs-3642	208	8	,	,	PUNCT
iajs-3642	208	9	hidalgo	hidalgo	PROPN
iajs-3642	208	10	m	m	PROPN
iajs-3642	208	11	,	,	PUNCT
iajs-3642	208	12	mendoza	mendoza	PROPN
iajs-3642	208	13	-	-	PUNCT
iajs-3642	208	14	león	león	PROPN
iajs-3642	208	15	a.	a.	NOUN
iajs-3642	208	16	comparative	comparative	PROPN
iajs-3642	208	17	analyses	analysis	NOUN
iajs-3642	208	18	of	of	ADP
iajs-3642	208	19	the	the	DET
iajs-3642	208	20	β‐tubulin	β‐tubulin	SYM
iajs-3642	208	21	gene	gene	NOUN
iajs-3642	208	22	and	and	CCONJ
iajs-3642	208	23	molecular	molecular	ADJ
iajs-3642	208	24	modeling	modeling	NOUN
iajs-3642	208	25	reveal	reveal	VERB
iajs-3642	208	26	molecular	molecular	ADJ
iajs-3642	208	27	insight	insight	NOUN
iajs-3642	208	28	into	into	ADP
iajs-3642	208	29	the	the	DET
iajs-3642	208	30	colchicine	colchicine	PROPN
iajs-3642	208	31	resistance	resistance	NOUN
iajs-3642	208	32	in	in	ADP
iajs-3642	208	33	kinetoplastids	kinetoplastids	PROPN
iajs-3642	208	34	organisms	organism	NOUN
iajs-3642	208	35	.	.	PUNCT
iajs-3642	209	1	biomed	biome	VERB
iajs-3642	209	2	research	research	NOUN
iajs-3642	209	3	international	international	PROPN
iajs-3642	209	4	.	.	PUNCT
iajs-3642	210	1	2013	2013	NUM
iajs-3642	210	2	;	;	PUNCT
iajs-3642	210	3	1:843748	1:843748	NUM
iajs-3642	210	4	.	.	PUNCT
iajs-3642	211	1	https://doi.org/10.1155/2013/843748	https://doi.org/10.1155/2013/843748	VERB
iajs-3642	211	2	7	7	NUM
iajs-3642	211	3	.	.	PUNCT
iajs-3642	212	1	supuran	supuran	PROPN
iajs-3642	212	2	ct	ct	PROPN
iajs-3642	212	3	.	.	PUNCT
iajs-3642	212	4	sulfonamides	sulfonamide	NOUN
iajs-3642	212	5	.	.	PUNCT
iajs-3642	213	1	molecules	molecule	NOUN
iajs-3642	213	2	,	,	PUNCT
iajs-3642	213	3	2017	2017	NUM
iajs-3642	213	4	;	;	PUNCT
iajs-3642	213	5	22(10):1–5	22(10):1–5	NUM
iajs-3642	213	6	.	.	PUNCT
iajs-3642	214	1	https://doi.org/10.3390/molecules22101642	https://doi.org/10.3390/molecules22101642	PROPN
iajs-3642	214	2	8	8	NUM
iajs-3642	214	3	.	.	PUNCT
iajs-3642	215	1	mohebali	mohebali	PROPN
iajs-3642	215	2	f	f	PROPN
iajs-3642	215	3	,	,	PUNCT
iajs-3642	215	4	nazifi	nazifi	PROPN
iajs-3642	215	5	z	z	PROPN
iajs-3642	215	6	,	,	PUNCT
iajs-3642	215	7	reza	reza	PROPN
iajs-3642	215	8	nazifi	nazifi	PROPN
iajs-3642	215	9	sm	sm	PROPN
iajs-3642	215	10	,	,	PUNCT
iajs-3642	215	11	mohammadian	mohammadian	ADJ
iajs-3642	215	12	h	h	NOUN
iajs-3642	215	13	,	,	PUNCT
iajs-3642	215	14	massah	massah	PROPN
iajs-3642	215	15	ar	ar	PROPN
iajs-3642	215	16	.	.	PROPN
iajs-3642	215	17	synthesis	synthesis	NOUN
iajs-3642	215	18	,	,	PUNCT
iajs-3642	215	19	molecular	molecular	ADJ
iajs-3642	215	20	docking	docking	NOUN
iajs-3642	215	21	studies	study	NOUN
iajs-3642	215	22	,	,	PUNCT
iajs-3642	215	23	and	and	CCONJ
iajs-3642	215	24	absorption	absorption	NOUN
iajs-3642	215	25	,	,	PUNCT
iajs-3642	215	26	distribution	distribution	NOUN
iajs-3642	215	27	,	,	PUNCT
iajs-3642	215	28	metabolism	metabolism	NOUN
iajs-3642	215	29	,	,	PUNCT
iajs-3642	215	30	and	and	CCONJ
iajs-3642	215	31	excretion	excretion	NOUN
iajs-3642	215	32	prediction	prediction	NOUN
iajs-3642	215	33	of	of	ADP
iajs-3642	215	34	novel	novel	ADJ
iajs-3642	215	35	sulfonamide	sulfonamide	NOUN
iajs-3642	215	36	derivatives	derivative	NOUN
iajs-3642	215	37	as	as	ADP
iajs-3642	215	38	antibacterial	antibacterial	ADJ
iajs-3642	215	39	agents	agent	NOUN
iajs-3642	215	40	.	.	PUNCT
iajs-3642	216	1	jccs	jccs	PROPN
iajs-3642	216	2	.	.	PROPN
iajs-3642	217	1	2019	2019	NUM
iajs-3642	217	2	;	;	PUNCT
iajs-3642	217	3	66(5):558	66(5):558	NUM
iajs-3642	217	4	–	–	PUNCT
iajs-3642	217	5	566	566	NUM
iajs-3642	217	6	.	.	NOUN
iajs-3642	217	7	https://doi.org/10.1002/jccs.201800207	https://doi.org/10.1002/jccs.201800207	NOUN
iajs-3642	217	8	.	.	PUNCT
iajs-3642	218	1	9	9	NUM
iajs-3642	218	2	.	.	X
iajs-3642	218	3	ullah	ullah	PROPN
iajs-3642	218	4	h	h	PROPN
iajs-3642	218	5	,	,	PUNCT
iajs-3642	218	6	rahim	rahim	PROPN
iajs-3642	218	7	f	f	PROPN
iajs-3642	218	8	,	,	PUNCT
iajs-3642	218	9	taha	taha	PROPN
iajs-3642	218	10	m	m	PROPN
iajs-3642	218	11	,	,	PUNCT
iajs-3642	218	12	uddin	uddin	PROPN
iajs-3642	218	13	i	i	PRON
iajs-3642	218	14	,	,	PUNCT
iajs-3642	218	15	wadood	wadood	PROPN
iajs-3642	218	16	a	a	PRON
iajs-3642	218	17	,	,	PUNCT
iajs-3642	218	18	shah	shah	PROPN
iajs-3642	218	19	saa	saa	PROPN
iajs-3642	218	20	,	,	PUNCT
iajs-3642	218	21	farooq	farooq	PROPN
iajs-3642	218	22	rk	rk	PROPN
iajs-3642	218	23	,	,	PUNCT
iajs-3642	218	24	nawaz	nawaz	NOUN
iajs-3642	218	25	m	m	PROPN
iajs-3642	218	26	,	,	PUNCT
iajs-3642	218	27	wahab	wahab	PROPN
iajs-3642	218	28	z	z	PROPN
iajs-3642	218	29	,	,	PUNCT
iajs-3642	218	30	khan	khan	PROPN
iajs-3642	218	31	k	k	PROPN
iajs-3642	218	32	m.	m.	NOUN
iajs-3642	218	33	synthesis	synthesis	NOUN
iajs-3642	218	34	,	,	PUNCT
iajs-3642	218	35	molecular	molecular	ADJ
iajs-3642	218	36	docking	docking	NOUN
iajs-3642	218	37	study	study	NOUN
iajs-3642	218	38	and	and	CCONJ
iajs-3642	218	39	in	in	ADP
iajs-3642	218	40	vitro	vitro	X
iajs-3642	218	41	thymidine	thymidine	ADJ
iajs-3642	218	42	phosphorylase	phosphorylase	NOUN
iajs-3642	218	43	inhibitory	inhibitory	ADJ
iajs-3642	218	44	potential	potential	NOUN
iajs-3642	218	45	of	of	ADP
iajs-3642	218	46	oxadiazole	oxadiazole	ADJ
iajs-3642	218	47	derivatives	derivative	NOUN
iajs-3642	218	48	.	.	PUNCT
iajs-3642	219	1	bioorgan	bioorgan	PROPN
iajs-3642	219	2	chem	chem	NOUN
iajs-3642	219	3	.	.	PUNCT
iajs-3642	220	1	2018	2018	NUM
iajs-3642	220	2	;	;	PUNCT
iajs-3642	220	3	78(8):58–67	78(8):58–67	NUM
iajs-3642	220	4	.	.	PUNCT
iajs-3642	221	1	https://doi.org/10.1016/j.bioorg.2018.02.020	https://doi.org/10.1016/j.bioorg.2018.02.020	NOUN
iajs-3642	221	2	.	.	PUNCT
iajs-3642	222	1	10	10	NUM
iajs-3642	222	2	.	.	PUNCT
iajs-3642	223	1	khan	khan	PROPN
iajs-3642	223	2	s	s	PROPN
iajs-3642	223	3	,	,	PUNCT
iajs-3642	223	4	iqbal	iqbal	PROPN
iajs-3642	223	5	,	,	PUNCT
iajs-3642	223	6	s	s	PROPN
iajs-3642	223	7	,	,	PUNCT
iajs-3642	223	8	shah	shah	PROPN
iajs-3642	223	9	m	m	PROPN
iajs-3642	223	10	,	,	PUNCT
iajs-3642	223	11	rehman	rehman	PROPN
iajs-3642	223	12	w	w	PROPN
iajs-3642	223	13	,	,	PUNCT
iajs-3642	223	14	hussain	hussain	PROPN
iajs-3642	223	15	r	r	PROPN
iajs-3642	223	16	,	,	PUNCT
iajs-3642	223	17	rasheed	rasheed	NOUN
iajs-3642	223	18	l	l	PROPN
iajs-3642	223	19	,	,	PUNCT
iajs-3642	223	20	alrbyawi	alrbyawi	PROPN
iajs-3642	223	21	h	h	NOUN
iajs-3642	223	22	,	,	PUNCT
iajs-3642	223	23	dera	dera	NOUN
iajs-3642	223	24	aa	aa	NOUN
iajs-3642	223	25	,	,	PUNCT
iajs-3642	223	26	alahmdi	alahmdi	PROPN
iajs-3642	223	27	mi	mi	PROPN
iajs-3642	223	28	,	,	PUNCT
iajs-3642	223	29	pashameah	pashameah	PROPN
iajs-3642	223	30	ra	ra	PROPN
iajs-3642	223	31	,	,	PUNCT
iajs-3642	223	32	alzahrani	alzahrani	PROPN
iajs-3642	223	33	e	e	PROPN
iajs-3642	223	34	,	,	PUNCT
iajs-3642	223	35	farouk	farouk	PROPN
iajs-3642	223	36	ae	ae	PROPN
iajs-3642	223	37	.	.	PUNCT
iajs-3642	224	1	synthesis	synthesis	NOUN
iajs-3642	224	2	,	,	PUNCT
iajs-3642	224	3	in	in	ADP
iajs-3642	224	4	vitro	vitro	X
iajs-3642	224	5	anti	anti	ADJ
iajs-3642	224	6	-	-	ADJ
iajs-3642	224	7	microbial	microbial	ADJ
iajs-3642	224	8	analysis	analysis	NOUN
iajs-3642	224	9	and	and	CCONJ
iajs-3642	224	10	molecular	molecular	ADJ
iajs-3642	224	11	docking	docking	NOUN
iajs-3642	224	12	study	study	NOUN
iajs-3642	224	13	of	of	ADP
iajs-3642	224	14	aliphatic	aliphatic	ADJ
iajs-3642	224	15	hydrazide	hydrazide	ADV
iajs-3642	224	16	-	-	PUNCT
iajs-3642	224	17	based	base	VERB
iajs-3642	224	18	benzene	benzene	NOUN
iajs-3642	224	19	sulphonamide	sulphonamide	NOUN
iajs-3642	224	20	derivatives	derivative	NOUN
iajs-3642	224	21	as	as	ADP
iajs-3642	224	22	potent	potent	ADJ
iajs-3642	224	23	inhibitors	inhibitor	NOUN
iajs-3642	224	24	of	of	ADP
iajs-3642	224	25	α	α	NOUN
iajs-3642	224	26	-	-	NOUN
iajs-3642	224	27	glucosidase	glucosidase	ADJ
iajs-3642	224	28	and	and	CCONJ
iajs-3642	224	29	urease	urease	VERB
iajs-3642	224	30	.	.	PUNCT
iajs-3642	225	1	molecule	molecule	NOUN
iajs-3642	225	2	.	.	PUNCT
iajs-3642	226	1	2022	2022	NUM
iajs-3642	226	2	;	;	PUNCT
iajs-3642	227	1	27(20):7129	27(20):7129	NUM
iajs-3642	227	2	.	.	PUNCT
iajs-3642	228	1	https://doi.org/10.3390/molecules27207129	https://doi.org/10.3390/molecules27207129	PROPN
iajs-3642	228	2	.	.	PUNCT
iajs-3642	229	1	11	11	NUM
iajs-3642	229	2	.	.	PUNCT
iajs-3642	230	1	noda	noda	PROPN
iajs-3642	230	2	s	s	PROPN
iajs-3642	230	3	,	,	PUNCT
iajs-3642	230	4	tanimori	tanimori	PROPN
iajs-3642	230	5	s.	s.	PROPN
iajs-3642	230	6	organic	organic	PROPN
iajs-3642	230	7	solvent	solvent	NOUN
iajs-3642	230	8	-	-	PUNCT
iajs-3642	230	9	free	free	ADJ
iajs-3642	230	10	synthesis	synthesis	NOUN
iajs-3642	230	11	of	of	ADP
iajs-3642	230	12	sulfonyl	sulfonyl	NOUN
iajs-3642	230	13	hydrazides	hydrazide	NOUN
iajs-3642	230	14	in	in	ADP
iajs-3642	230	15	water	water	NOUN
iajs-3642	230	16	.	.	PUNCT
iajs-3642	231	1	tetrahedron	tetrahedron	PROPN
iajs-3642	231	2	green	green	PROPN
iajs-3642	231	3	chem	chem	PROPN
iajs-3642	231	4	.	.	PUNCT
iajs-3642	232	1	2023	2023	NUM
iajs-3642	232	2	;	;	PUNCT
iajs-3642	232	3	(	(	PUNCT
iajs-3642	232	4	1):100001	1):100001	NUM
iajs-3642	232	5	.	.	PUNCT
iajs-3642	233	1	https://doi.org/10.1016/j.tgchem.2022.100001	https://doi.org/10.1016/j.tgchem.2022.100001	PROPN
iajs-3642	233	2	.	.	PUNCT
iajs-3642	234	1	12	12	NUM
iajs-3642	234	2	.	.	PUNCT
iajs-3642	235	1	liu	liu	PROPN
iajs-3642	235	2	x	x	PROPN
iajs-3642	235	3	,	,	PUNCT
iajs-3642	235	4	liang	liang	PROPN
iajs-3642	235	5	j	j	PROPN
iajs-3642	235	6	,	,	PUNCT
iajs-3642	235	7	yu	yu	PROPN
iajs-3642	235	8	y	y	PROPN
iajs-3642	235	9	,	,	PUNCT
iajs-3642	235	10	han	han	PROPN
iajs-3642	235	11	x	x	PROPN
iajs-3642	235	12	,	,	PUNCT
iajs-3642	235	13	yu	yu	PROPN
iajs-3642	235	14	l	l	PROPN
iajs-3642	235	15	,	,	PUNCT
iajs-3642	235	16	chen	chen	PROPN
iajs-3642	235	17	f	f	PROPN
iajs-3642	235	18	,	,	PUNCT
iajs-3642	235	19	xu	xu	PROPN
iajs-3642	236	1	z	z	PROPN
iajs-3642	236	2	,	,	PUNCT
iajs-3642	236	3	chen	chen	PROPN
iajs-3642	236	4	q	q	PROPN
iajs-3642	236	5	,	,	PUNCT
iajs-3642	236	6	jin	jin	PROPN
iajs-3642	236	7	m	m	PROPN
iajs-3642	236	8	,	,	PUNCT
iajs-3642	236	9	dong	dong	PROPN
iajs-3642	236	10	c	c	PROPN
iajs-3642	236	11	,	,	PUNCT
iajs-3642	236	12	zhou	zhou	PROPN
iajs-3642	236	13	h	h	PROPN
iajs-3642	236	14	,	,	PUNCT
iajs-3642	236	15	lan	lan	PROPN
iajs-3642	236	16	k	k	PROPN
iajs-3642	236	17	,	,	PUNCT
iajs-3642	236	18	wu	wu	PROPN
iajs-3642	236	19	s.	s.	PROPN
iajs-3642	236	20	discovery	discovery	PROPN
iajs-3642	236	21	of	of	ADP
iajs-3642	236	22	aryl	aryl	NOUN
iajs-3642	236	23	benzoyl	benzoyl	NOUN
iajs-3642	236	24	hydrazide	hydrazide	ADJ
iajs-3642	236	25	derivatives	derivative	NOUN
iajs-3642	236	26	as	as	ADP
iajs-3642	236	27	novel	novel	NOUN
iajs-3642	236	28	potent	potent	ADJ
iajs-3642	236	29	broad	broad	ADJ
iajs-3642	236	30	spectrum	spectrum	NOUN
iajs-3642	236	31	inhibitors	inhibitor	NOUN
iajs-3642	236	32	of	of	ADP
iajs-3642	236	33	influenza	influenza	NOUN
iajs-3642	236	34	a	a	DET
iajs-3642	236	35	virus	virus	NOUN
iajs-3642	236	36	rna	rna	NOUN
iajs-3642	236	37	-	-	PUNCT
iajs-3642	236	38	dependent	dependent	ADJ
iajs-3642	236	39	rna	rna	NOUN
iajs-3642	236	40	polymerase	polymerase	NOUN
iajs-3642	236	41	(	(	PUNCT
iajs-3642	236	42	rdrp	rdrp	PROPN
iajs-3642	236	43	)	)	PUNCT
iajs-3642	236	44	.	.	PUNCT
iajs-3642	237	1	jmc	jmc	PROPN
iajs-3642	237	2	.	.	PUNCT
iajs-3642	238	1	2022	2022	NUM
iajs-3642	238	2	;	;	PUNCT
iajs-3642	238	3	65(5):3814	65(5):3814	NUM
iajs-3642	238	4	-	-	SYM
iajs-3642	238	5	3832	3832	NUM
iajs-3642	238	6	.	.	PUNCT
iajs-3642	239	1	https://doi.org/10.1021/acs.jmedchem.1c01257	https://doi.org/10.1021/acs.jmedchem.1c01257	NOUN
iajs-3642	239	2	.	.	PROPN
iajs-3642	239	3	13	13	NUM
iajs-3642	239	4	.	.	PUNCT
iajs-3642	240	1	guo	guo	PROPN
iajs-3642	240	2	s	s	PROPN
iajs-3642	240	3	,	,	PUNCT
iajs-3642	240	4	abusalim	abusalim	PROPN
iajs-3642	240	5	di	di	NOUN
iajs-3642	240	6	,	,	PUNCT
iajs-3642	240	7	cook	cook	VERB
iajs-3642	240	8	sp	sp	NOUN
iajs-3642	240	9	.	.	PUNCT
iajs-3642	240	10	aqueous	aqueous	ADJ
iajs-3642	240	11	benzylic	benzylic	NOUN
iajs-3642	240	12	c	c	NOUN
iajs-3642	240	13	-	-	PUNCT
iajs-3642	240	14	h	h	NOUN
iajs-3642	240	15	trifluoromethylation	trifluoromethylation	NOUN
iajs-3642	240	16	for	for	ADP
iajs-3642	240	17	late	late	ADJ
iajs-3642	240	18	-	-	PUNCT
iajs-3642	240	19	stage	stage	NOUN
iajs-3642	240	20	functionalization	functionalization	NOUN
iajs-3642	240	21	.	.	PUNCT
iajs-3642	241	1	jacs	jacs	PROPN
iajs-3642	241	2	.	.	PROPN
iajs-3642	241	3	2018	2018	NUM
iajs-3642	241	4	;	;	PUNCT
iajs-3642	241	5	140(39):12378–12382	140(39):12378–12382	NUM
iajs-3642	241	6	.	.	PUNCT
iajs-3642	242	1	https://doi.org/10.1021/jacs.8b08547	https://doi.org/10.1021/jacs.8b08547	PROPN
iajs-3642	242	2	.	.	PROPN
iajs-3642	243	1	14	14	NUM
iajs-3642	243	2	.	.	PUNCT
iajs-3642	244	1	al	al	PROPN
iajs-3642	244	2	-	-	PUNCT
iajs-3642	244	3	majidi	majidi	PROPN
iajs-3642	244	4	s	s	PROPN
iajs-3642	244	5	,	,	PUNCT
iajs-3642	244	6	al	al	PROPN
iajs-3642	244	7	-	-	PUNCT
iajs-3642	244	8	jeilawi	jeilawi	PROPN
iajs-3642	244	9	u	u	PROPN
iajs-3642	244	10	,	,	PUNCT
iajs-3642	244	11	al	al	PROPN
iajs-3642	244	12	-	-	PUNCT
iajs-3642	244	13	saadie	saadie	PROPN
iajs-3642	244	14	k.	k.	PROPN
iajs-3642	244	15	synthesis	synthesis	NOUN
iajs-3642	244	16	and	and	CCONJ
iajs-3642	244	17	characterization	characterization	NOUN
iajs-3642	244	18	of	of	ADP
iajs-3642	244	19	some	some	DET
iajs-3642	244	20	2	2	NUM
iajs-3642	244	21	-	-	PUNCT
iajs-3642	244	22	sulphanyl	sulphanyl	NOUN
iajs-3642	244	23	benzimidazole	benzimidazole	NOUN
iajs-3642	244	24	derivatives	derivative	NOUN
iajs-3642	244	25	and	and	CCONJ
iajs-3642	244	26	study	study	NOUN
iajs-3642	244	27	of	of	ADP
iajs-3642	244	28	effect	effect	NOUN
iajs-3642	244	29	as	as	ADP
iajs-3642	244	30	corrosion	corrosion	NOUN
iajs-3642	244	31	inhibitors	inhibitor	NOUN
iajs-3642	244	32	for	for	ADP
iajs-3642	244	33	carbon	carbon	NOUN
iajs-3642	244	34	steel	steel	NOUN
iajs-3642	244	35	in	in	ADP
iajs-3642	244	36	sulfuric	sulfuric	ADJ
iajs-3642	244	37	acid	acid	NOUN
iajs-3642	244	38	solution	solution	NOUN
iajs-3642	244	39	.	.	PUNCT
iajs-3642	245	1	ijs	ijs	PROPN
iajs-3642	245	2	.	.	PROPN
iajs-3642	246	1	2013	2013	NUM
iajs-3642	246	2	;	;	PUNCT
iajs-3642	247	1	54(4):789–802	54(4):789–802	NUM
iajs-3642	247	2	.	.	NOUN
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iajs-3642	247	4	.	.	PUNCT
iajs-3642	248	1	al	al	PROPN
iajs-3642	248	2	-	-	PUNCT
iajs-3642	248	3	zahra	zahra	PROPN
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iajs-3642	248	5	,	,	PUNCT
iajs-3642	248	6	al	al	PROPN
iajs-3642	248	7	-	-	PUNCT
iajs-3642	248	8	ani	ani	NOUN
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iajs-3642	248	10	,	,	PUNCT
iajs-3642	248	11	al	al	PROPN
iajs-3642	248	12	-	-	PUNCT
iajs-3642	248	13	jeilawi	jeilawi	PROPN
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iajs-3642	248	15	.	.	PUNCT
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iajs-3642	249	7	-	-	PUNCT
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iajs-3642	249	10	(	(	PUNCT
iajs-3642	249	11	bmq	bmq	NOUN
iajs-3642	249	12	)	)	PUNCT
iajs-3642	249	13	as	as	ADP
iajs-3642	249	14	an	an	DET
iajs-3642	249	15	inhibitor	inhibitor	NOUN
iajs-3642	249	16	of	of	ADP
iajs-3642	249	17	carbon	carbon	NOUN
iajs-3642	249	18	steel	steel	NOUN
iajs-3642	249	19	corrosion	corrosion	NOUN
iajs-3642	249	20	in	in	ADP
iajs-3642	249	21	acidic	acidic	ADJ
iajs-3642	249	22	media	medium	NOUN
iajs-3642	249	23	.	.	PUNCT
iajs-3642	250	1	ijsn	ijsn	VERB
iajs-3642	250	2	.	.	PUNCT
iajs-3642	251	1	2018	2018	NUM
iajs-3642	251	2	;	;	PUNCT
iajs-3642	252	1	9(1):105–113	9(1):105–113	NUM
iajs-3642	252	2	.	.	NOUN
iajs-3642	253	1	16	16	NUM
iajs-3642	253	2	.	.	PUNCT
iajs-3642	254	1	zhu	zhu	PROPN
iajs-3642	254	2	h	h	PROPN
iajs-3642	254	3	,	,	PUNCT
iajs-3642	254	4	zhang	zhang	PROPN
iajs-3642	254	5	y	y	PROPN
iajs-3642	254	6	,	,	PUNCT
iajs-3642	254	7	liu	liu	PROPN
iajs-3642	254	8	y	y	PROPN
iajs-3642	254	9	,	,	PUNCT
iajs-3642	254	10	yang	yang	PROPN
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iajs-3642	254	12	,	,	PUNCT
iajs-3642	254	13	xie	xie	PROPN
iajs-3642	255	1	z	z	PROPN
iajs-3642	255	2	,	,	PUNCT
iajs-3642	255	3	jiang	jiang	PROPN
iajs-3642	255	4	g	g	PROPN
iajs-3642	255	5	,	,	PUNCT
iajs-3642	255	6	le	le	PROPN
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iajs-3642	255	8	.	.	PUNCT
iajs-3642	256	1	a	a	DET
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iajs-3642	256	3	and	and	CCONJ
iajs-3642	256	4	practical	practical	ADJ
iajs-3642	256	5	sulfonylation	sulfonylation	NOUN
iajs-3642	256	6	of	of	ADP
iajs-3642	256	7	benzylic	benzylic	ADJ
iajs-3642	256	8	ammonium	ammonium	NOUN
iajs-3642	256	9	salts	salt	NOUN
iajs-3642	256	10	with	with	ADP
iajs-3642	256	11	sulfonyl	sulfonyl	NOUN
iajs-3642	256	12	hydrazides	hydrazide	NOUN
iajs-3642	256	13	for	for	ADP
iajs-3642	256	14	the	the	DET
iajs-3642	256	15	synthesis	synthesis	NOUN
iajs-3642	256	16	of	of	ADP
iajs-3642	256	17	sulfones	sulfone	NOUN
iajs-3642	256	18	.	.	PUNCT
iajs-3642	257	1	tetl	tetl	NOUN
iajs-3642	257	2	.	.	PUNCT
iajs-3642	258	1	2020	2020	NUM
iajs-3642	258	2	;	;	PUNCT
iajs-3642	258	3	61(24	61(24	NUM
iajs-3642	258	4	):	):	PUNCT
iajs-3642	258	5	151975	151975	NUM
iajs-3642	258	6	.	.	PUNCT
iajs-3642	259	1	http://dx.doi.org/10.1016/j.tetlet.2020.151975	http://dx.doi.org/10.1016/j.tetlet.2020.151975	PROPN
iajs-3642	259	2	.	.	PUNCT
iajs-3642	260	1	17	17	NUM
iajs-3642	260	2	.	.	PUNCT
iajs-3642	261	1	han	han	PROPN
iajs-3642	261	2	m	m	PROPN
iajs-3642	261	3	i̇	i̇	PROPN
iajs-3642	261	4	,	,	PUNCT
iajs-3642	261	5	gürol	gürol	VERB
iajs-3642	261	6	g	g	PROPN
iajs-3642	261	7	,	,	PUNCT
iajs-3642	261	8	yıldırım	yıldırım	PROPN
iajs-3642	261	9	t	t	PROPN
iajs-3642	261	10	,	,	PUNCT
iajs-3642	261	11	kalaycı	kalaycı	PROPN
iajs-3642	261	12	s	s	PROPN
iajs-3642	261	13	,	,	PUNCT
iajs-3642	261	14	şahin	şahin	PROPN
iajs-3642	261	15	f	f	PROPN
iajs-3642	261	16	,	,	PUNCT
iajs-3642	261	17	küçükgüzel	küçükgüzel	PROPN
iajs-3642	261	18	şg	şg	NOUN
iajs-3642	261	19	.	.	PUNCT
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iajs-3642	261	22	antibacterial	antibacterial	ADJ
iajs-3642	261	23	activity	activity	NOUN
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iajs-3642	261	25	new	new	ADJ
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iajs-3642	261	27	-	-	PUNCT
iajs-3642	261	28	hydrazones	hydrazone	NOUN
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iajs-3642	261	30	from	from	ADP
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iajs-3642	261	32	.	.	PUNCT
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iajs-3642	262	4	.	.	PUNCT
iajs-3642	263	1	2017	2017	NUM
iajs-3642	263	2	;	;	PUNCT
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iajs-3642	263	4	.	.	NOUN
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iajs-3642	264	2	.	.	PUNCT
iajs-3642	265	1	ghosh	ghosh	PROPN
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iajs-3642	265	6	,	,	PUNCT
iajs-3642	265	7	halder	halder	PROPN
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iajs-3642	265	9	,	,	PUNCT
iajs-3642	265	10	cordeiro	cordeiro	PROPN
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iajs-3642	265	12	.	.	PUNCT
iajs-3642	266	1	in	in	ADP
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iajs-3642	266	4	of	of	ADP
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iajs-3642	266	7	hydrazide	hydrazide	ADJ
iajs-3642	266	8	derivatives	derivative	NOUN
iajs-3642	266	9	as	as	ADP
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iajs-3642	266	13	rdrp	rdrp	NOUN
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iajs-3642	267	3	.	.	PUNCT
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iajs-3642	268	2	;	;	PUNCT
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iajs-3642	268	4	:	:	PUNCT
iajs-3642	268	5	1–16	1–16	NOUN
iajs-3642	268	6	.	.	PUNCT
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iajs-3642	269	2	.	.	NOUN
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iajs-3642	269	4	.	.	PUNCT
iajs-3642	270	1	allawi	allawi	PROPN
iajs-3642	270	2	mm	mm	PROPN
iajs-3642	270	3	,	,	PUNCT
iajs-3642	270	4	mahdi	mahdi	PROPN
iajs-3642	270	5	mf	mf	PROPN
iajs-3642	270	6	,	,	PUNCT
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iajs-3642	270	16	molecular	molecular	ADJ
iajs-3642	270	17	docking	docking	NOUN
iajs-3642	270	18	and	and	CCONJ
iajs-3642	270	19	adme	adme	NOUN
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iajs-3642	270	25	https://doi.org/10.1016/j.bioorg.2018.02.020	https://doi.org/10.1016/j.bioorg.2018.02.020	PROPN
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iajs-3642	270	30	http://dx.doi.org/10.1016/j.tetlet.2020.151975	http://dx.doi.org/10.1016/j.tetlet.2020.151975	PROPN
iajs-3642	270	31	https://doi.org/10.3389/fphar.2022.1004255	https://doi.org/10.3389/fphar.2022.1004255	PROPN
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iajs-3642	270	33	.	.	PUNCT
iajs-3642	271	1	2025	2025	NUM
iajs-3642	271	2	,	,	PUNCT
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iajs-3642	271	4	(	(	PUNCT
iajs-3642	271	5	1	1	NUM
iajs-3642	271	6	)	)	PUNCT
iajs-3642	271	7	325	325	NUM
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iajs-3642	271	14	as	as	ADP
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iajs-3642	271	16	inhibitor	inhibitor	NOUN
iajs-3642	271	17	.	.	PUNCT
iajs-3642	272	1	ajps	ajps	ADJ
iajs-3642	272	2	.	.	PUNCT
iajs-3642	273	1	2019	2019	NUM
iajs-3642	273	2	;	;	PUNCT
iajs-3642	273	3	19(4):125	19(4):125	NUM
iajs-3642	273	4	-	-	SYM
iajs-3642	273	5	139	139	NUM
iajs-3642	273	6	.	.	PUNCT
iajs-3642	274	1	https://ajps.uomustansiriyah.edu.iq/index.php/ajps/article/view/644	https://ajps.uomustansiriyah.edu.iq/index.php/ajps/article/view/644	PROPN
iajs-3642	274	2	.	.	PROPN
iajs-3642	275	1	20	20	NUM
iajs-3642	275	2	.	.	PUNCT
iajs-3642	276	1	kadhim	kadhim	PROPN
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iajs-3642	276	4	lafta	lafta	PROPN
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iajs-3642	276	9	.	.	PROPN
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iajs-3642	276	11	in	in	ADP
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iajs-3642	276	13	,	,	PUNCT
iajs-3642	276	14	pharmacological	pharmacological	ADJ
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iajs-3642	276	16	,	,	PUNCT
iajs-3642	276	17	molecular	molecular	ADJ
iajs-3642	276	18	docking	docking	NOUN
iajs-3642	276	19	and	and	CCONJ
iajs-3642	276	20	adme	adme	VERB
iajs-3642	276	21	studies	study	NOUN
iajs-3642	276	22	of	of	ADP
iajs-3642	276	23	schiff	schiff	NOUN
iajs-3642	276	24	bases	basis	NOUN
iajs-3642	276	25	of	of	ADP
iajs-3642	276	26	diclofenac	diclofenac	NOUN
iajs-3642	276	27	targeting	target	VERB
iajs-3642	276	28	cox-2	cox-2	NOUN
iajs-3642	276	29	.	.	PUNCT
iajs-3642	277	1	j	j	PROPN
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iajs-3642	277	4	.	.	PUNCT
iajs-3642	278	1	2020	2020	NUM
iajs-3642	278	2	;	;	PUNCT
iajs-3642	278	3	11(2	11(2	NUM
iajs-3642	278	4	):	):	PUNCT
iajs-3642	278	5	88	88	NUM
iajs-3642	278	6	-	-	SYM
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iajs-3642	278	8	.	.	PUNCT
iajs-3642	278	9	21	21	NUM
iajs-3642	278	10	.	.	PUNCT
iajs-3642	279	1	rasheed	rasheed	PROPN
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iajs-3642	279	3	,	,	PUNCT
iajs-3642	279	4	al	al	PROPN
iajs-3642	279	5	-	-	PUNCT
iajs-3642	279	6	majidi	majidi	PROPN
iajs-3642	279	7	smh	smh	PROPN
iajs-3642	279	8	.	.	PUNCT
iajs-3642	279	9	synthesis	synthesis	NOUN
iajs-3642	279	10	,	,	PUNCT
iajs-3642	279	11	identification	identification	NOUN
iajs-3642	279	12	and	and	CCONJ
iajs-3642	279	13	evaluation	evaluation	NOUN
iajs-3642	279	14	of	of	ADP
iajs-3642	279	15	molecular	molecular	ADJ
iajs-3642	279	16	docking	docking	NOUN
iajs-3642	279	17	and	and	CCONJ
iajs-3642	279	18	experimental	experimental	ADJ
iajs-3642	279	19	anti	anti	ADJ
iajs-3642	279	20	-	-	ADJ
iajs-3642	279	21	cancer	cancer	ADJ
iajs-3642	279	22	and	and	CCONJ
iajs-3642	279	23	antioxidant	antioxidant	ADJ
iajs-3642	279	24	activity	activity	NOUN
iajs-3642	279	25	of	of	ADP
iajs-3642	279	26	new	new	ADJ
iajs-3642	279	27	spiro	spiro	NOUN
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iajs-3642	279	30	ring	ring	NOUN
iajs-3642	279	31	derivatives	derivative	NOUN
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iajs-3642	279	34	-	-	PUNCT
iajs-3642	279	35	nitro	nitro	NOUN
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iajs-3642	279	39	product	product	NOUN
iajs-3642	279	40	research	research	NOUN
iajs-3642	279	41	.	.	PUNCT
iajs-3642	280	1	2023	2023	NUM
iajs-3642	280	2	;	;	PUNCT
iajs-3642	280	3	38(15):2629–2636	38(15):2629–2636	NUM
iajs-3642	280	4	.	.	PUNCT
iajs-3642	281	1	https://doi.org/10.1080/14786419.2023.2195178	https://doi.org/10.1080/14786419.2023.2195178	PROPN
iajs-3642	281	2	.	.	PUNCT
iajs-3642	282	1	22	22	NUM
iajs-3642	282	2	.	.	PUNCT
iajs-3642	283	1	arshad	arshad	PROPN
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iajs-3642	283	3	,	,	PUNCT
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iajs-3642	283	6	,	,	PUNCT
iajs-3642	283	7	channar	channar	PROPN
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iajs-3642	283	9	a	a	PRON
iajs-3642	283	10	,	,	PUNCT
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iajs-3642	283	13	,	,	PUNCT
iajs-3642	283	14	saeed	saeed	PROPN
iajs-3642	283	15	ws	ws	PROPN
iajs-3642	283	16	,	,	PUNCT
iajs-3642	283	17	perveen	perveen	VERB
iajs-3642	283	18	f	f	PROPN
iajs-3642	283	19	,	,	PUNCT
iajs-3642	283	20	javed	javed	PROPN
iajs-3642	283	21	a	a	X
iajs-3642	283	22	,	,	PUNCT
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iajs-3642	283	24	h	h	PROPN
iajs-3642	283	25	,	,	PUNCT
iajs-3642	283	26	mir	mir	PROPN
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iajs-3642	283	28	,	,	PUNCT
iajs-3642	283	29	ahmed	ahme	VERB
iajs-3642	283	30	a	a	PROPN
iajs-3642	283	31	,	,	PUNCT
iajs-3642	283	32	azad	azad	PROPN
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iajs-3642	283	35	khan	khan	PROPN
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iajs-3642	283	40	synthesized	synthesize	VERB
iajs-3642	283	41	bis	bis	ADJ
iajs-3642	283	42	-	-	ADJ
iajs-3642	283	43	acyl	acyl	ADJ
iajs-3642	283	44	-	-	PUNCT
iajs-3642	283	45	thiourea	thiourea	NOUN
iajs-3642	283	46	derivatives	derivative	NOUN
iajs-3642	283	47	of	of	ADP
iajs-3642	283	48	4nitrobenzene-1,2	4nitrobenzene-1,2	NUM
iajs-3642	283	49	-	-	PUNCT
iajs-3642	283	50	diamine	diamine	NOUN
iajs-3642	283	51	for	for	ADP
iajs-3642	283	52	their	their	PRON
iajs-3642	283	53	dna	dna	NOUN
iajs-3642	283	54	binding	bind	VERB
iajs-3642	283	55	,	,	PUNCT
iajs-3642	283	56	urease	urease	VERB
iajs-3642	283	57	inhibition	inhibition	NOUN
iajs-3642	283	58	,	,	PUNCT
iajs-3642	283	59	and	and	CCONJ
iajs-3642	283	60	anti	anti	ADJ
iajs-3642	283	61	-	-	ADJ
iajs-3642	283	62	brain	brain	ADJ
iajs-3642	283	63	-	-	PUNCT
iajs-3642	283	64	tumor	tumor	NOUN
iajs-3642	283	65	activities	activity	NOUN
iajs-3642	283	66	.	.	PUNCT
iajs-3642	284	1	molecules	molecule	NOUN
iajs-3642	284	2	.	.	PUNCT
iajs-3642	285	1	2023	2023	NUM
iajs-3642	285	2	;	;	PUNCT
iajs-3642	286	1	28(6):2707	28(6):2707	NUM
iajs-3642	286	2	.	.	PUNCT
iajs-3642	287	1	https://doi.org/10.3390/molecules28062707	https://doi.org/10.3390/molecules28062707	PROPN
iajs-3642	287	2	.	.	PUNCT
iajs-3642	288	1	23	23	NUM
iajs-3642	288	2	.	.	PUNCT
iajs-3642	288	3	raauf	raauf	PROPN
iajs-3642	288	4	amr	amr	PROPN
iajs-3642	288	5	,	,	PUNCT
iajs-3642	288	6	omar	omar	PROPN
iajs-3642	288	7	tna	tna	PROPN
iajs-3642	288	8	,	,	PUNCT
iajs-3642	288	9	mahdi	mahdi	PROPN
iajs-3642	288	10	mf	mf	PROPN
iajs-3642	288	11	,	,	PUNCT
iajs-3642	288	12	fadhil	fadhil	PROPN
iajs-3642	288	13	hr	hr	PROPN
iajs-3642	288	14	.	.	PUNCT
iajs-3642	289	1	synthesis	synthesis	NOUN
iajs-3642	289	2	,	,	PUNCT
iajs-3642	289	3	molecular	molecular	ADJ
iajs-3642	289	4	docking	docking	NOUN
iajs-3642	289	5	and	and	CCONJ
iajs-3642	289	6	anti	anti	ADJ
iajs-3642	289	7	-	-	ADJ
iajs-3642	289	8	inflammatory	inflammatory	ADJ
iajs-3642	289	9	evaluation	evaluation	NOUN
iajs-3642	289	10	of	of	ADP
iajs-3642	289	11	new	new	ADJ
iajs-3642	289	12	trisubstituted	trisubstituted	ADJ
iajs-3642	289	13	pyrazoline	pyrazoline	NOUN
iajs-3642	289	14	derivatives	derivative	NOUN
iajs-3642	289	15	bearing	bear	VERB
iajs-3642	289	16	benzenesulfonamide	benzenesulfonamide	ADP
iajs-3642	289	17	moiety	moiety	NOUN
iajs-3642	289	18	.	.	PUNCT
iajs-3642	290	1	natural	natural	ADJ
iajs-3642	290	2	product	product	NOUN
iajs-3642	290	3	research	research	NOUN
iajs-3642	290	4	.	.	PUNCT
iajs-3642	291	1	2022	2022	NUM
iajs-3642	291	2	;	;	PUNCT
iajs-3642	291	3	38(2):253	38(2):253	NUM
iajs-3642	291	4	-	-	PUNCT
iajs-3642	291	5	260	260	NUM
iajs-3642	291	6	.	.	PUNCT
iajs-3642	292	1	http://dx.doi.org/10.1080/14786419.2022.2117174	http://dx.doi.org/10.1080/14786419.2022.2117174	INTJ
iajs-3642	292	2	.	.	PUNCT
iajs-3642	293	1	24	24	NUM
iajs-3642	293	2	.	.	PUNCT
iajs-3642	294	1	mohammad	mohammad	PROPN
iajs-3642	294	2	ha	ha	PROPN
iajs-3642	294	3	,	,	PUNCT
iajs-3642	294	4	musa	musa	PROPN
iajs-3642	294	5	f	f	PROPN
iajs-3642	294	6	,	,	PUNCT
iajs-3642	294	7	abdullah	abdullah	PROPN
iajs-3642	294	8	ai	ai	PROPN
iajs-3642	294	9	.	.	PUNCT
iajs-3642	294	10	synthesis	synthesis	NOUN
iajs-3642	294	11	and	and	CCONJ
iajs-3642	294	12	studies	study	NOUN
iajs-3642	294	13	of	of	ADP
iajs-3642	294	14	1	1	NUM
iajs-3642	294	15	,	,	PUNCT
iajs-3642	294	16	2bis	2bis	NUM
iajs-3642	294	17	(	(	PUNCT
iajs-3642	294	18	5	5	NUM
iajs-3642	294	19	-	-	SYM
iajs-3642	294	20	2	2	NUM
iajs-3642	294	21	thiolethylsuphide-1	thiolethylsuphide-1	NOUN
iajs-3642	294	22	,	,	PUNCT
iajs-3642	294	23	3,4	3,4	NUM
iajs-3642	294	24	-	-	PUNCT
iajs-3642	294	25	oxadiazole-2yl	oxadiazole-2yl	ADJ
iajs-3642	294	26	)	)	PUNCT
iajs-3642	294	27	ethane	ethane	NOUN
iajs-3642	294	28	and	and	CCONJ
iajs-3642	294	29	it	it	PRON
iajs-3642	294	30	's	be	AUX
iajs-3642	294	31	complexes	complex	NOUN
iajs-3642	294	32	with	with	ADP
iajs-3642	294	33	(	(	PUNCT
iajs-3642	294	34	m	m	PROPN
iajs-3642	294	35	(	(	PUNCT
iajs-3642	294	36	ii	ii	PROPN
iajs-3642	294	37	):	):	PUNCT
iajs-3642	294	38	cu	cu	PROPN
iajs-3642	294	39	,	,	PUNCT
iajs-3642	294	40	ni	ni	PROPN
iajs-3642	294	41	,	,	PUNCT
iajs-3642	294	42	co	co	NOUN
iajs-3642	294	43	,	,	PUNCT
iajs-3642	294	44	hg	hg	NOUN
iajs-3642	294	45	)	)	PUNCT
iajs-3642	294	46	.	.	PUNCT
iajs-3642	295	1	rjs	rjs	PROPN
iajs-3642	295	2	.	.	PUNCT
iajs-3642	295	3	2009	2009	NUM
iajs-3642	295	4	;	;	PUNCT
iajs-3642	295	5	20(1):75–89	20(1):75–89	NUM
iajs-3642	295	6	.	.	PUNCT
iajs-3642	296	1	http://dx.doi.org/10.33899/rjs.2009.41330	http://dx.doi.org/10.33899/rjs.2009.41330	PROPN
iajs-3642	296	2	.	.	PROPN
iajs-3642	296	3	25	25	NUM
iajs-3642	296	4	.	.	PUNCT
iajs-3642	297	1	santosa	santosa	PROPN
iajs-3642	297	2	h	h	PROPN
iajs-3642	297	3	,	,	PUNCT
iajs-3642	297	4	putra	putra	PROPN
iajs-3642	297	5	gs	gs	PROPN
iajs-3642	297	6	,	,	PUNCT
iajs-3642	297	7	yuniarta	yuniarta	PROPN
iajs-3642	297	8	ta	ta	PROPN
iajs-3642	297	9	,	,	PUNCT
iajs-3642	297	10	budiati	budiati	NOUN
iajs-3642	297	11	t.	t.	NOUN
iajs-3642	297	12	synthesis	synthesis	NOUN
iajs-3642	297	13	and	and	CCONJ
iajs-3642	297	14	molecular	molecular	ADJ
iajs-3642	297	15	docking	docking	NOUN
iajs-3642	297	16	studies	study	NOUN
iajs-3642	297	17	of	of	ADP
iajs-3642	297	18	n’benzoylsalicylhydrazide	n’benzoylsalicylhydrazide	ADP
iajs-3642	297	19	derivatives	derivative	NOUN
iajs-3642	297	20	as	as	ADP
iajs-3642	297	21	antituberculosis	antituberculosis	NOUN
iajs-3642	297	22	through	through	ADP
iajs-3642	297	23	inha	inha	NOUN
iajs-3642	297	24	enzyme	enzyme	NOUN
iajs-3642	297	25	inhibition	inhibition	NOUN
iajs-3642	297	26	.	.	PUNCT
iajs-3642	298	1	indonesian	indonesian	PROPN
iajs-3642	298	2	j	j	PROPN
iajs-3642	298	3	pharm	pharm	PROPN
iajs-3642	298	4	.	.	PUNCT
iajs-3642	299	1	2018	2018	NUM
iajs-3642	299	2	;	;	PUNCT
iajs-3642	300	1	29(4):198–205	29(4):198–205	NUM
iajs-3642	300	2	.	.	PUNCT
iajs-3642	301	1	http://dx.doi.org/10.14499/indonesianjpharm29iss4pp198	http://dx.doi.org/10.14499/indonesianjpharm29iss4pp198	ADJ
iajs-3642	301	2	.	.	PUNCT
iajs-3642	302	1	26	26	NUM
iajs-3642	302	2	.	.	PUNCT
iajs-3642	302	3	channar	channar	PROPN
iajs-3642	302	4	sa	sa	PROPN
iajs-3642	302	5	,	,	PUNCT
iajs-3642	302	6	channar	channar	PROPN
iajs-3642	302	7	pa	pa	PROPN
iajs-3642	302	8	,	,	PUNCT
iajs-3642	302	9	saeed	saeed	PROPN
iajs-3642	302	10	a	a	PRON
iajs-3642	302	11	,	,	PUNCT
iajs-3642	302	12	alsfouk	alsfouk	INTJ
iajs-3642	302	13	aa	aa	PROPN
iajs-3642	302	14	,	,	PUNCT
iajs-3642	302	15	ejaz	ejaz	PROPN
iajs-3642	302	16	sa	sa	PROPN
iajs-3642	302	17	,	,	PUNCT
iajs-3642	302	18	ujan	ujan	NOUN
iajs-3642	302	19	r	r	NOUN
iajs-3642	302	20	,	,	PUNCT
iajs-3642	302	21	noor	noor	PROPN
iajs-3642	302	22	r	r	PROPN
iajs-3642	302	23	,	,	PUNCT
iajs-3642	302	24	bilal	bilal	PROPN
iajs-3642	302	25	ms	ms	PROPN
iajs-3642	302	26	,	,	PUNCT
iajs-3642	302	27	abbas	abbas	PROPN
iajs-3642	302	28	q	q	PROPN
iajs-3642	302	29	,	,	PUNCT
iajs-3642	302	30	hussain	hussain	PROPN
iajs-3642	302	31	z	z	PROPN
iajs-3642	302	32	,	,	PUNCT
iajs-3642	302	33	khan	khan	PROPN
iajs-3642	302	34	ba	ba	PROPN
iajs-3642	302	35	,	,	PUNCT
iajs-3642	302	36	raza	raza	PROPN
iajs-3642	302	37	h	h	PROPN
iajs-3642	302	38	,	,	PUNCT
iajs-3642	302	39	indher	indher	ADJ
iajs-3642	302	40	hab	hab	NOUN
iajs-3642	302	41	,	,	PUNCT
iajs-3642	302	42	mahesar	mahesar	PROPN
iajs-3642	302	43	pa	pa	PROPN
iajs-3642	302	44	.	.	PUNCT
iajs-3642	303	1	exploring	explore	VERB
iajs-3642	303	2	thiazole	thiazole	NOUN
iajs-3642	303	3	-	-	PUNCT
iajs-3642	303	4	linked	link	VERB
iajs-3642	303	5	thioureas	thiourea	NOUN
iajs-3642	303	6	using	use	VERB
iajs-3642	303	7	alkaline	alkaline	NOUN
iajs-3642	303	8	phosphatase	phosphatase	NOUN
iajs-3642	303	9	assay	assay	VERB
iajs-3642	303	10	,	,	PUNCT
iajs-3642	303	11	biochemical	biochemical	ADJ
iajs-3642	303	12	evaluation	evaluation	NOUN
iajs-3642	303	13	,	,	PUNCT
iajs-3642	303	14	computational	computational	ADJ
iajs-3642	303	15	analysis	analysis	NOUN
iajs-3642	303	16	and	and	CCONJ
iajs-3642	303	17	structure	structure	NOUN
iajs-3642	303	18	–	–	PUNCT
iajs-3642	303	19	activity	activity	NOUN
iajs-3642	303	20	relationship	relationship	NOUN
iajs-3642	303	21	(	(	PUNCT
iajs-3642	303	22	sar	sar	NOUN
iajs-3642	303	23	)	)	PUNCT
iajs-3642	303	24	studies	study	NOUN
iajs-3642	303	25	.	.	PUNCT
iajs-3642	304	1	med	med	ADJ
iajs-3642	304	2	chem	chem	NOUN
iajs-3642	304	3	res	re	NOUN
iajs-3642	304	4	.	.	PUNCT
iajs-3642	304	5	2022	2022	NUM
iajs-3642	304	6	;	;	PUNCT
iajs-3642	304	7	31(10):1792–1802	31(10):1792–1802	NUM
iajs-3642	304	8	.	.	PUNCT
iajs-3642	304	9	https://doi.org/10.1007/s00044022-02945-4	https://doi.org/10.1007/s00044022-02945-4	NOUN
iajs-3642	304	10	.	.	PUNCT
iajs-3642	305	1	27	27	NUM
iajs-3642	305	2	.	.	PUNCT
iajs-3642	306	1	salvatore	salvatore	PROPN
iajs-3642	306	2	rn	rn	PROPN
iajs-3642	306	3	,	,	PUNCT
iajs-3642	306	4	yoon	yoon	PROPN
iajs-3642	306	5	ch	ch	PROPN
iajs-3642	306	6	,	,	PUNCT
iajs-3642	306	7	jung	jung	PROPN
iajs-3642	306	8	kw	kw	PROPN
iajs-3642	306	9	.	.	PUNCT
iajs-3642	306	10	synthesis	synthesis	NOUN
iajs-3642	306	11	of	of	ADP
iajs-3642	306	12	secondary	secondary	ADJ
iajs-3642	306	13	amines	amine	NOUN
iajs-3642	306	14	.	.	PUNCT
iajs-3642	307	1	tetrahedron	tetrahedron	NOUN
iajs-3642	307	2	.	.	PUNCT
iajs-3642	308	1	2001	2001	NUM
iajs-3642	308	2	;	;	PUNCT
iajs-3642	309	1	57(37	57(37	NUM
iajs-3642	309	2	):	):	PUNCT
iajs-3642	309	3	77857811	77857811	NUM
iajs-3642	309	4	.	.	PUNCT
iajs-3642	310	1	https://doi.org/10.1016/s0040-4020(01)00722-0	https://doi.org/10.1016/s0040-4020(01)00722-0	PROPN
iajs-3642	310	2	.	.	PUNCT
iajs-3642	311	1	28	28	NUM
iajs-3642	311	2	.	.	PUNCT
iajs-3642	312	1	erol	erol	PROPN
iajs-3642	312	2	m	m	PRON
iajs-3642	312	3	,	,	PUNCT
iajs-3642	312	4	celik	celik	VERB
iajs-3642	312	5	i	i	PRON
iajs-3642	312	6	,	,	PUNCT
iajs-3642	312	7	uzunhisarcikli	uzunhisarcikli	ADJ
iajs-3642	312	8	e	e	NOUN
iajs-3642	312	9	,	,	PUNCT
iajs-3642	312	10	kuyucuklu	kuyucuklu	PROPN
iajs-3642	312	11	g.	g.	PROPN
iajs-3642	312	12	synthesis	synthesis	PROPN
iajs-3642	312	13	,	,	PUNCT
iajs-3642	312	14	molecular	molecular	ADJ
iajs-3642	312	15	docking	docking	NOUN
iajs-3642	312	16	,	,	PUNCT
iajs-3642	312	17	and	and	CCONJ
iajs-3642	312	18	dft	dft	PROPN
iajs-3642	312	19	studies	study	NOUN
iajs-3642	312	20	of	of	ADP
iajs-3642	312	21	some	some	DET
iajs-3642	312	22	new	new	ADJ
iajs-3642	312	23	2,5	2,5	NUM
iajs-3642	312	24	-	-	PUNCT
iajs-3642	312	25	disubstituted	disubstitute	VERB
iajs-3642	312	26	benzoxazoles	benzoxazole	NOUN
iajs-3642	312	27	as	as	ADP
iajs-3642	312	28	potential	potential	ADJ
iajs-3642	312	29	antimicrobial	antimicrobial	ADJ
iajs-3642	312	30	and	and	CCONJ
iajs-3642	312	31	cytotoxic	cytotoxic	ADJ
iajs-3642	312	32	agents	agent	NOUN
iajs-3642	312	33	.	.	PUNCT
iajs-3642	313	1	pacs	pac	NOUN
iajs-3642	313	2	.	.	PUNCT
iajs-3642	314	1	2022	2022	NUM
iajs-3642	314	2	;	;	PUNCT
iajs-3642	315	1	42(4):1679–1696	42(4):1679–1696	X
iajs-3642	315	2	.	.	PUNCT
iajs-3642	316	1	https://doi.org/10.1080/10406638.2020.1802305	https://doi.org/10.1080/10406638.2020.1802305	PROPN
iajs-3642	316	2	.	.	PUNCT
iajs-3642	317	1	29	29	NUM
iajs-3642	317	2	.	.	PUNCT
iajs-3642	318	1	hussen	hussen	PROPN
iajs-3642	318	2	nh	nh	PROPN
iajs-3642	318	3	.	.	PUNCT
iajs-3642	318	4	synthesis	synthesis	NOUN
iajs-3642	318	5	,	,	PUNCT
iajs-3642	318	6	characterization	characterization	NOUN
iajs-3642	318	7	,	,	PUNCT
iajs-3642	318	8	molecular	molecular	ADJ
iajs-3642	318	9	docking	docking	NOUN
iajs-3642	318	10	,	,	PUNCT
iajs-3642	318	11	admet	admet	PROPN
iajs-3642	318	12	prediction	prediction	NOUN
iajs-3642	318	13	,	,	PUNCT
iajs-3642	318	14	and	and	CCONJ
iajs-3642	318	15	anti	anti	ADJ
iajs-3642	318	16	inflammatory	inflammatory	ADJ
iajs-3642	318	17	activity	activity	NOUN
iajs-3642	318	18	of	of	ADP
iajs-3642	318	19	some	some	DET
iajs-3642	318	20	schiff	schiff	NOUN
iajs-3642	318	21	bases	basis	NOUN
iajs-3642	318	22	derived	derive	VERB
iajs-3642	318	23	from	from	ADP
iajs-3642	318	24	salicylaldehyde	salicylaldehyde	NOUN
iajs-3642	318	25	as	as	ADP
iajs-3642	318	26	a	a	DET
iajs-3642	318	27	potential	potential	ADJ
iajs-3642	318	28	cyclooxygenase	cyclooxygenase	NOUN
iajs-3642	318	29	inhibitor	inhibitor	NOUN
iajs-3642	318	30	.	.	PUNCT
iajs-3642	319	1	baghdad	baghdad	PROPN
iajs-3642	319	2	sci	sci	PROPN
iajs-3642	319	3	j.	j.	PROPN
iajs-3642	319	4	2023	2023	NUM
iajs-3642	319	5	;	;	PUNCT
iajs-3642	319	6	20(5):1662	20(5):1662	X
iajs-3642	319	7	-	-	SYM
iajs-3642	319	8	1674	1674	NUM
iajs-3642	319	9	.	.	PUNCT
iajs-3642	320	1	https://doi.org/10.21123/bsj.2023.7405	https://doi.org/10.21123/bsj.2023.7405	NOUN
iajs-3642	320	2	.	.	PUNCT
iajs-3642	321	1	30	30	NUM
iajs-3642	321	2	.	.	PUNCT
iajs-3642	322	1	azzam	azzam	PROPN
iajs-3642	322	2	ra	ra	PROPN
iajs-3642	322	3	,	,	PUNCT
iajs-3642	322	4	elboshi	elboshi	PROPN
iajs-3642	322	5	ha	ha	PROPN
iajs-3642	322	6	,	,	PUNCT
iajs-3642	322	7	elgemeie	elgemeie	PROPN
iajs-3642	322	8	gh	gh	PROPN
iajs-3642	322	9	.	.	PUNCT
iajs-3642	323	1	synthesis	synthesis	PROPN
iajs-3642	323	2	,	,	PUNCT
iajs-3642	323	3	physicochemical	physicochemical	ADJ
iajs-3642	323	4	properties	property	NOUN
iajs-3642	323	5	and	and	CCONJ
iajs-3642	323	6	molecular	molecular	ADJ
iajs-3642	323	7	docking	docking	NOUN
iajs-3642	323	8	of	of	ADP
iajs-3642	323	9	new	new	ADJ
iajs-3642	323	10	benzothiazole	benzothiazole	NOUN
iajs-3642	323	11	derivatives	derivative	NOUN
iajs-3642	323	12	as	as	ADP
iajs-3642	323	13	antimicrobial	antimicrobial	ADJ
iajs-3642	323	14	agents	agent	NOUN
iajs-3642	323	15	targeting	target	VERB
iajs-3642	323	16	dhps	dhps	ADJ
iajs-3642	323	17	enzyme	enzyme	NOUN
iajs-3642	323	18	.	.	PUNCT
iajs-3642	324	1	antibiotics	antibiotic	NOUN
iajs-3642	324	2	.	.	PUNCT
iajs-3642	325	1	2022	2022	NUM
iajs-3642	325	2	;	;	PUNCT
iajs-3642	325	3	11(12):1799	11(12):1799	NUM
iajs-3642	325	4	.	.	PUNCT
iajs-3642	325	5	https://doi.org/10.3390/antibiotics11121799	https://doi.org/10.3390/antibiotics11121799	PROPN
iajs-3642	325	6	.	.	PUNCT
iajs-3642	326	1	31	31	NUM
iajs-3642	326	2	.	.	PUNCT
iajs-3642	327	1	silverstein	silverstein	PROPN
iajs-3642	327	2	rm	rm	PROPN
iajs-3642	327	3	,	,	PUNCT
iajs-3642	327	4	webster	webster	PROPN
iajs-3642	327	5	fx	fx	PROPN
iajs-3642	327	6	,	,	PUNCT
iajs-3642	327	7	kiemle	kiemle	PROPN
iajs-3642	327	8	j.	j.	PROPN
iajs-3642	327	9	spectrometric	spectrometric	PROPN
iajs-3642	327	10	identification	identification	NOUN
iajs-3642	327	11	of	of	ADP
iajs-3642	327	12	organic	organic	ADJ
iajs-3642	327	13	compounds	compound	NOUN
iajs-3642	327	14	,	,	PUNCT
iajs-3642	327	15	7th	7th	ADJ
iajs-3642	327	16	ed	ed	NOUN
iajs-3642	327	17	.	.	PUNCT
iajs-3642	328	1	new	new	PROPN
iajs-3642	328	2	york	york	PROPN
iajs-3642	328	3	,	,	PUNCT
iajs-3642	328	4	united	united	PROPN
iajs-3642	328	5	states	states	PROPN
iajs-3642	328	6	:	:	PUNCT
iajs-3642	328	7	john	john	PROPN
iajs-3642	328	8	wiley	wiley	PROPN
iajs-3642	328	9	&	&	CCONJ
iajs-3642	328	10	sons	sons	PROPN
iajs-3642	328	11	,	,	PUNCT
iajs-3642	328	12	ine	ine	PROPN
iajs-3642	328	13	.	.	PROPN
iajs-3642	328	14	2005	2005	NUM
iajs-3642	328	15	.	.	PUNCT
iajs-3642	329	1	32	32	NUM
iajs-3642	329	2	.	.	PUNCT
iajs-3642	330	1	lipinski	lipinski	PROPN
iajs-3642	330	2	ca	ca	PROPN
iajs-3642	330	3	,	,	PUNCT
iajs-3642	330	4	lombardo	lombardo	PROPN
iajs-3642	330	5	f	f	PROPN
iajs-3642	330	6	,	,	PUNCT
iajs-3642	330	7	dominy	dominy	ADJ
iajs-3642	330	8	bw	bw	NOUN
iajs-3642	330	9	,	,	PUNCT
iajs-3642	330	10	feeney	feeney	PROPN
iajs-3642	330	11	pj	pj	PROPN
iajs-3642	330	12	.	.	PROPN
iajs-3642	331	1	experimental	experimental	ADJ
iajs-3642	331	2	and	and	CCONJ
iajs-3642	331	3	computational	computational	ADJ
iajs-3642	331	4	approaches	approach	NOUN
iajs-3642	331	5	to	to	PART
iajs-3642	331	6	estimate	estimate	VERB
iajs-3642	331	7	solubility	solubility	NOUN
iajs-3642	331	8	and	and	CCONJ
iajs-3642	331	9	permeability	permeability	NOUN
iajs-3642	331	10	in	in	ADP
iajs-3642	331	11	drug	drug	NOUN
iajs-3642	331	12	discovery	discovery	NOUN
iajs-3642	331	13	and	and	CCONJ
iajs-3642	331	14	development	development	NOUN
iajs-3642	331	15	settings	setting	NOUN
iajs-3642	331	16	.	.	PUNCT
iajs-3642	332	1	adv	adv	PROPN
iajs-3642	332	2	drug	drug	PROPN
iajs-3642	332	3	deliv	deliv	PROPN
iajs-3642	332	4	rev	rev	VERB
iajs-3642	332	5	.	.	PROPN
iajs-3642	332	6	1997	1997	NUM
iajs-3642	332	7	;	;	PUNCT
iajs-3642	332	8	23(1	23(1	NUM
iajs-3642	332	9	-	-	PUNCT
iajs-3642	332	10	3):3	3):3	NUM
iajs-3642	332	11	-	-	SYM
iajs-3642	332	12	25	25	NUM
iajs-3642	332	13	.	.	PUNCT
iajs-3642	333	1	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
iajs-3642	333	2	.	.	PUNCT
iajs-3642	334	1	https://ajps.uomustansiriyah.edu.iq/index.php/ajps/article/view/644	https://ajps.uomustansiriyah.edu.iq/index.php/ajps/article/view/644	PROPN
iajs-3642	334	2	https://doi.org/10.1080/14786419.2023.2195178	https://doi.org/10.1080/14786419.2023.2195178	PROPN
iajs-3642	334	3	https://doi.org/10.3390/molecules28062707	https://doi.org/10.3390/molecules28062707	PROPN
iajs-3642	334	4	http://dx.doi.org/10.1080/14786419.2022.2117174	http://dx.doi.org/10.1080/14786419.2022.2117174	ADV
iajs-3642	334	5	http://dx.doi.org/10.33899/rjs.2009.41330	http://dx.doi.org/10.33899/rjs.2009.41330	PRON
iajs-3642	334	6	http://dx.doi.org/10.14499/indonesianjpharm29iss4pp198	http://dx.doi.org/10.14499/indonesianjpharm29iss4pp198	ADJ
iajs-3642	334	7	.	.	PUNCT
iajs-3642	335	1	https://doi.org/10.1007/s00044-022-02945-4	https://doi.org/10.1007/s00044-022-02945-4	NOUN
iajs-3642	335	2	https://doi.org/10.1007/s00044-022-02945-4	https://doi.org/10.1007/s00044-022-02945-4	NUM
iajs-3642	335	3	https://doi.org/10.1016/s0040-4020(01)00722-0	https://doi.org/10.1016/s0040-4020(01)00722-0	NOUN
iajs-3642	335	4	https://doi.org/10.1080/10406638.2020.1802305	https://doi.org/10.1080/10406638.2020.1802305	PROPN
iajs-3642	335	5	https://doi.org/10.21123/bsj.2023.7405	https://doi.org/10.21123/bsj.2023.7405	PROPN
iajs-3642	335	6	https://doi.org/10.3390/antibiotics11121799	https://doi.org/10.3390/antibiotics11121799	PROPN
iajs-3642	335	7	https://doi.org/10.1016/s0169-409x(00)00129-0	https://doi.org/10.1016/s0169-409x(00)00129-0	PROPN
iajs-3642	335	8	all	all	DET
iajs-3642	335	9	chemical	chemical	NOUN
iajs-3642	335	10	compounds	compound	NOUN
iajs-3642	335	11	were	be	AUX
iajs-3642	335	12	used	use	VERB
iajs-3642	335	13	without	without	ADP
iajs-3642	335	14	further	further	ADJ
iajs-3642	335	15	purification	purification	NOUN
iajs-3642	335	16	and	and	CCONJ
iajs-3642	335	17	obtained	obtain	VERB
iajs-3642	335	18	from	from	ADP
iajs-3642	335	19	bdh	bdh	NOUN
iajs-3642	335	20	,	,	PUNCT
iajs-3642	335	21	fluka	fluka	NOUN
iajs-3642	335	22	,	,	PUNCT
iajs-3642	335	23	aldrich	aldrich	NOUN
iajs-3642	335	24	,	,	PUNCT
iajs-3642	335	25	and	and	CCONJ
iajs-3642	335	26	merck	merck	PROPN
iajs-3642	335	27	companies	company	NOUN
iajs-3642	335	28	.	.	PUNCT
iajs-3642	336	1	thin	thin	ADJ
iajs-3642	336	2	-	-	PUNCT
iajs-3642	336	3	layer	layer	NOUN
iajs-3642	336	4	chromatography	chromatography	NOUN
iajs-3642	336	5	(	(	PUNCT
iajs-3642	336	6	tlc	tlc	NOUN
iajs-3642	336	7	)	)	PUNCT
iajs-3642	336	8	was	be	AUX
iajs-3642	336	9	used	use	VERB
iajs-3642	336	10	on	on	ADP
iajs-3642	336	11	pre	pre	ADJ
iajs-3642	336	12	-	-	ADJ
iajs-3642	336	13	coated	coated	ADJ
iajs-3642	336	14	merck	merck	NOUN
iajs-3642	336	15	(	(	PUNCT
iajs-3642	336	16	macherey	macherey	PROPN
iajs-3642	336	17	-	-	PUNCT
iajs-3642	336	18	nagel	nagel	PROPN
iajs-3642	336	19	,	,	PUNCT
iajs-3642	336	20	germany	germany	PROPN
iajs-3642	336	21	)	)	PUNCT
iajs-3642	336	22	silica	silica	NOUN
iajs-3642	336	23	gel	gel	NOUN
iajs-3642	336	24	60	60	NUM
iajs-3642	336	25	-	-	PUNCT
iajs-3642	336	26	f	f	NOUN
iajs-3642	336	27	plates	plate	NOUN
iajs-3642	336	28	with	with	ADP
iajs-3642	336	29	a	a	DET
iajs-3642	336	30	layer	layer	NOUN
iajs-3642	336	31	thickn	thickn	NOUN
iajs-3642	336	32	...	...	PUNCT