item: #1 of 77 id: ijpds-2438 author: Tahilani, Praveen; Banweer, Jitendra; Chatterjee, D P; Goyanar, Gaurav; Sharma, Abhishek title: Nutraceuticals and Fortified Foods Supplements in India: Challenges and Opportunities - A Comprehensive Review date: 2023 words: 3307 flesch: 58 summary: [7] Another term often used as a synonym with functional foods is “nutraceuticals,” Several factors are responsible for the fact that this is one of the most promising areas of research in the nutrition sciences today which gives an emphasis in nutritional and medical research on associations between diet and dietary constituents and health benefits, and a favorable regulatory environment including the consumer self- care phenomenon, and rapid growth in the market for health and wellness products is observed [8]. Functional foods of animal origin: Recently the most popular class of physiologically-active components derived from animal products are the (n-3) fatty acids, predominantly found in fatty fish such as salmon, tuna, mackerel, sardines and herring keywords: disease; foods; fortification; health; human; india; institute; nutraceuticals; nutrition; research cache: ijpds-2438.pdf plain text: ijpds-2438.txt item: #2 of 77 id: ijpds-2904 author: Sakshi; Singh, Gaaminepreet title: Role of membrane transporters in Cisplatin induced nephrotoxicity date: 2023 words: 3788 flesch: 49 summary: Copper Transporter 1 (CTR1) Copper transporter 1 (Ctr1, Solute Carrier 31A1-SLC31A1) is a membrane protein that plays a significant role in the cellular cisplatin uptake. Copper Transporter 2 (CTR2) Copper transporter 2 (Ctr2, SLC31A2) is a copper transport protein with substantia structural homology to Ctr1. keywords: cancer; cells; cisplatin; copper; ctr1; drug; membrane; nephrotoxicity; platinum; transporters cache: ijpds-2904.pdf plain text: ijpds-2904.txt item: #3 of 77 id: ijpds-2950 author: Sujeetha Purushothaman; Arumugan Vijaya Anand title: The Link between Cholesterol and a Brain Disease date: 2023 words: 3721 flesch: 60 summary: Physical activity and Alzheimer disease: a protective association. The genetic landscape of Alzheimer disease: clinical implications and perspectives. keywords: alzheimer; apoe; brain; cholesterol; disease; lipid; metabolism; risk; studies cache: ijpds-2950.pdf plain text: ijpds-2950.txt item: #4 of 77 id: ijpds-2957 author: Vasthi Kennedy Evanjelene; Ganesh Velu title: Preliminary phytochemical, Proximate and Nutrient Analysis indifferent leaf extracts of Jatropha curcas L date: 2023 words: 4545 flesch: 57 summary: Plant extracts were subjected to phytochemical examination, which indicated the existence of constituents with medicinal and physiological properties [27]. [4].Synthetic products abound on the market, with high premiums, adverse side effects, and environmental consequences [5] Medicinal plants and drugs extracted from them, on the other hand, are less expensive and have fewer side effects, making them common with the public [6]. keywords: analysis; ash; content; curcas; extracts; medicinal; methanol; plants; protein; proximate; value cache: ijpds-2957.pdf plain text: ijpds-2957.txt item: #5 of 77 id: ijpds-2959 author: Santhadani Lenin; Sujatha Ramasamy; Deivasigamani Revathy title: Evaluate the Effectiveness of Phytochemical, Physicochemical and Mineral Analysis of Moringa oleifera (Drum Stick Leaves) date: 2023 words: 3266 flesch: 57 summary: Phytochemical Analysis: The qualitative phytochemical study of M. Oleifera leaves was carried out. The presence of heavy metals was determined using elemental analysis, and the results for M. Oleifera leaf powder in ppm are Iron (Fe) - 0.548, Copper (Cu) - 0.075, Manganese (Mn) - 0.038, Zinc (Zn) - 0.138, Nickel (Ni) - 0.133, Cobalt (Co) - 0.547, Lead (Pb) - 0.486, Aluminum (Al) - 1.984, Vanadium (V) - 1.096, Chromium (Cr) - 0.048, Molybdenum (Mo) - 0.137, Mercury (Hg) - 0.145, Arsenic (As) - 0.052, Cadmium (Cd) - 0.098.The most common nutritional deficiency has been described as iron deficiency anemia, which is estimated to affect more than one billion people worldwide keywords: analysis; colour; drug; iron; leaves; mineral; moringa; oleifera; plant; properties cache: ijpds-2959.pdf plain text: ijpds-2959.txt item: #6 of 77 id: ijpds-2964 author: Bhoge ND; Mohite PB; Deshmukh VK; Magare BK title: A Comprehensive Review on Synthetic Strategy of Benzothiazole Lead and Pharmacological Importance date: 2023 words: 2664 flesch: 43 summary: Fig.2 Compounds chosen for MTT assay Asatkar et al., reported that the aqueous extracts of rice husk derived chemically activated carbon acts as a catalyzed for the synthesis of benzothiazole, benzoxazole and N-benzimidazole in room temperature by converting 2-aminothiophenol, 2amino phenol and ortho-phenylene di-amine with aromatic aldehydes with 98%yeild [7] (Fig. Benzothiazole derivative can be synthesized by using conventional, microwave method or by other green chemistry method. keywords: activities; activity; anticancer; benzothiazole; compounds; derivatives; synthesis cache: ijpds-2964.pdf plain text: ijpds-2964.txt item: #7 of 77 id: ijpds-3082 author: Somanaboina Padmakar title: A Case Report on Neurofibromatosis Associated with Infective Mass Tumor date: 2023 words: 1453 flesch: 59 summary: 1 Neurofibromas associated with infective mass tumor over left forearm Table 1: Drugs prescribed to the patient Drug name Dose Route Freque ncy Dura tion Inj. International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. keywords: mass; neurofibromatosis; nf1; tumor; type cache: ijpds-3082.pdf plain text: ijpds-3082.txt item: #8 of 77 id: ijpds-3102 author: Nidhi Chauhan; Sonali Agarwa title: Piracetam induced psychotic symptoms in a preadolescent girl with intellectual disability date: 2023 words: 1229 flesch: 35 summary: No history of seizures, other neurodevelopmental disorders, substance use, skin rash (porphyria), drug use (steroids) was obtained. Casual, unsupervised, nonmedical use of nootropic drugs to improve academic performance could have unanticipated negative mental health effects. keywords: disability; drug; effects; piracetam; use cache: ijpds-3102.pdf plain text: ijpds-3102.txt item: #9 of 77 id: ijpds-3132 author: Vamakshi Thaker; A.K. Singhai; Dilip Kumar Tiwari title: Formulation and Characterization of Clotrimazole Micro Emulsion for Topical Drug Delivery date: 2023 words: 4513 flesch: 55 summary: Assay % 99.6 ± 0.22 99.1 ± 0.30 99.0 ± 0.30 pH 5.46 ± 0.22 5.4 ± 0.20 5.42 ± 0.20 result of stability of M icro emulsion gel at refriger ation temperature Assay % 99.6 ± 2.42 98.9 ± 1.23 98.6 ± 1.13 pH 5.99 ± 0.20 5.99 ± 0.14 5.97 ± 0.12 Transparency Transparency & clear Transparency & clear Transparency & clear Viscosity Very good Very good Very good Figure 4 - FTIR Spectroscopy of clotrimazole drug. It is sold in most developed countries worldwide under a variety of trade names, and a large number of clotrimazole formulations are available. keywords: clotrimazole; clotrimazole micro; drug; emulsion; formulation; gel; micro; micro emulsion; oil cache: ijpds-3132.pdf plain text: ijpds-3132.txt item: #10 of 77 id: ijpds-3133 author: Raju Maski; Jitendra Banweer; Megha Mishra; Praveen Tahilani; Gaurav Goyanar title: Advances in Ocular Drug Delivery System for Glaucoma Management – A Comprehensive Review date: 2023 words: 7951 flesch: 57 summary: Bloomfield et al. developed the drug delivery model for the collagen shields. Chauhan et al. developed the technique using Vitamin E as an in-situ transport barrier for timolol. keywords: contact; delivery; drug; drug delivery; et al; eye; glaucoma; iop; lenses; nanoparticles; ophthalmol; patients; pharm; pilocarpine; reduction; release; studies; system; timolol cache: ijpds-3133.pdf plain text: ijpds-3133.txt item: #11 of 77 id: ijpds-3217 author: Marilia Amável Gomes Soares; Otávio Augusto Chaves; Dilson Silva; Dari Cesarin-Sobrinho``; Célia Martins Cortez; Antônio Augusto Fidalgo Neto title: Effect of Glucose Concentrations on the HSA-Hydrochlorothiazide Interaction – a study using Circular Dichroism and Molecular Docking date: 2023 words: 4831 flesch: 60 summary: For this, HSA solutions containing GLU 80 mg/dl and 320 mg/dl were used named normoglycemic and hyperglycemic solutions, respectively. [22], optical cuvette length (1.0 cm), and molar HSA concentration (10-6 M), respectively. keywords: albumin; binding; docking; glucose; hctz; hsa; interaction; structure cache: ijpds-3217.pdf plain text: ijpds-3217.txt item: #12 of 77 id: ijpds-3318 author: Prathap Bingi; Shaik Kareemulla; B. Himabindu; Khan, D. Sheklane ; Ramu, G. ; Rafi, S. Mahammed title: A Comparitive Study on Efficacy and Safety of Vildagliptin-Metformin versus Glimepiride - Metformin in Type 2 Diabetes Mellitus Patients date: 2023 words: 4361 flesch: 57 summary: Figure 3: Graphical representation of patients based on co- morbidities (V-M; G-M) DISCUSSION On evaluation, it was found that a significant reduction of HbA1C, FBS, and RBS levels was noted in VM group patients when compared to GM group patients. In terms of the safety profile, more ADRs were noted in GM group patients than in VM group patients. keywords: diabetes; glimepiride; group; metformin; patients; safety; study; type; vildagliptin cache: ijpds-3318.pdf plain text: ijpds-3318.txt item: #13 of 77 id: ijpds-3481 author: Praveen Tahilani; Hemant Swami; Gaurav Goyanar; Shivani Tiwari title: The Era of Artificial Intelligence in Pharmaceutical Industries - A review date: 2023 words: 3172 flesch: 47 summary: Artificial intelligence (AI) has become more prevalent in a number of societal fields, most notably the pharmaceutical industry. Artificial intelligence. keywords: artificial; data; development; drug; industry; intelligence; learning; pharmaceutical; technology; use cache: ijpds-3481.pdf plain text: ijpds-3481.txt item: #14 of 77 id: ijpds-3504 author: Sakhare, Ghansham R; Yelwande, Purva ; Suryawanshi, Sandhya ; Ambhore, Kiran ; Pawar, Rutuja ; Jain, Kishor title: Pharmacovigilance study on the increased use of antibiotics in pediatric treatment: Pharmacovigilance of antibiotic usage date: 2023 words: 2952 flesch: 51 summary: Around 97 % groups said they went to doctor after occurrence of adverse drug reaction, 98 % percent groups said they were aware of the risks of self-medication. The occurrence of adverse drug reactions (ADR’s) is an-other problem with antibiotic use. keywords: adr; antibiotics; drug; groups; pharmacovigilance; use cache: ijpds-3504.pdf plain text: ijpds-3504.txt item: #15 of 77 id: ijpds-3542 author: Thaker, Vamakshi; Verma, Jyoti; Waghmare, Suchita; Mourya, Navinraj title: Formulation and Evaluation of Rapidly Dissolving Film containing Antihistaminic drugs (Levocetirizine dihydrochloride) date: 2023 words: 2671 flesch: 46 summary: DISCUSSION The comparison of the effect of individual superdisintegrants on the wetting time, disintegration time and dissolution showed that SSG was more suitable for the formulation of oral dispersible tablets of Levocetirizine dihydrochloride as compared to other superdisintegrants used in the current study. Hence, from the present study, it can be concluded that the Thaker et al. Formulation and Evaluation of Levocetrizine dihydrochloride Vol 2 / Issue 1 / Jan - Mar 2023 Indian J Pharm Drug Studies | 26 superdisintegrants SSG and CP in appropriate concentration can be used to develop oral dispersible tablets of Levocetirizine dihydrochloride by direct compression method. keywords: dihydrochloride; disintegration; dissolution; drug; formulation; histamine; levocetirizine; tablets; time cache: ijpds-3542.pdf plain text: ijpds-3542.txt item: #16 of 77 id: ijpds-3543 author: Sonwani, Hari; Virendra Kumar Sharma; Steffi Thomas; Akhlesh Kumar title: Adenosine receptor agonists suppress macrophage inflammatory protein -1α production and collagen induced arthritis date: 2023 words: 5141 flesch: 51 summary: We conclude that adenosine receptor agonists, particularly the A3 agonist IB-MECA, inhibit MIP-α synthesis and have anti-inflammatory properties. This LPS concentration is higher than that employed in investigations on the effects of adenosine receptor agonists on MIP-1α generation. keywords: adenosine; agonist; arthritis; il-12; lps; meca; mip-1α; production; receptor cache: ijpds-3543.pdf plain text: ijpds-3543.txt item: #17 of 77 id: ijpds-3575 author: Singh, Ayush ; Isher, Jatin ; Sehgal, Riya; Manju; Kumari, Neeru; Kaur, Karamjit title: Molnupiravir and Favipiravir in the therapeutics of SARS-CoV-2 - A review date: 2023 words: 2822 flesch: 50 summary: Anti-viral drugs prevent viral replication through several kinds of mechanisms or physiology. It is a selective and potent inhibitor of RdRp of RNA viruses. keywords: cov-2; covid-19; drug; favipiravir; molnupiravir; rna; sars; virus cache: ijpds-3575.pdf plain text: ijpds-3575.txt item: #18 of 77 id: ijpds-3583 author: Shaikhmulani, Hasan; Tamboli, Ashpak M ; Tamboli, Naziya A ; Kshirsagar, Rohan T title: RP-HPLC Method Development and Validation for Simultaneous Estimation of Benidipine Hydrochloride and Chlorthalidone in Pharmaceutical Dosage Form date: 2023 words: 2957 flesch: 52 summary: Shaikhmulani et al. RP-HPLC method development and validation of BEN.HCL & CTD Vol 1 | Issue 3 | Oct - Apr 2022 Indian J Pharm Drug Studies | 102 Original Article RP-HPLC Method Development and Validation for Simultaneous Estimation of Benidipine Hydrochloride and Chlorthalidone in Pharmaceutical Dosage Form ABSTRACT A simple, precise, rapid and accurate reverse phase High Performance Liquid Chromatography (HPLC) method was developed for the estimation of Benidipine Hydrochloride and Chlorthalidone in bulk and tablet dosage form. keywords: benidipine; chlorthalidone; hydrochloride; method cache: ijpds-3583.pdf plain text: ijpds-3583.txt item: #19 of 77 id: ijpds-3602 author: Suthar, Pallavi; Mashru, Rajashree title: Advanced UV Spectrophotometric Method Development and Validation for Simultaneous Estimation of Azelnidipine and Telmisartan in Pharmaceutical Dosage Form date: 2023 words: 3627 flesch: 54 summary: First derivative method LOD AZL 0.35 0.16 1.8 TEL 0.73 0.77 1.71 LOQ AZL 0.927 0.048 5.4 TEL 2.16 2.34 5.16 Table 6 – Two way ANOVA ANOVA Source of Variation SS DF MS F P-Value F Crit Sample 0.59535 3 0.19845 0.710972 0.55952 3.238872 Suthar and Mashru Advanced UV Spectrophotometric Method Development and Validation Vol 2 | Issue 1 | Jan – Mar 2023 Indian J Pharm Drug Studies | 32 Columns 0.464816667 1 0.464816669 1.665263 0.215232 4.493998 Interaction 1.100816667 3 0.366938889 1.314604 0.304208 3.238872 Within 4.466 16 0.279125 Total 6.626983333 23 CONCLUSION The simple, rapid, accurate, and precise simultaneous methods, Q absorbance ratio and first derivative methods of UV spectroscopy have been developed and validated for the routine analysis of AZL and TEL in API and pharmaceutical dosage form. The resulting solutions were analyzed for drug content by spectrophotometric method at 255 nm and 297 nm for AZL and TEL, respectively. keywords: azelnidipine; azl; method; simultaneous; telmisartan cache: ijpds-3602.pdf plain text: ijpds-3602.txt item: #20 of 77 id: ijpds-3611 author: Shinde, Pradnya; Kadav, Shraddha; Kamble, Ashwini; Tamboli, Ashpak title: In vitro pharmacological investigation of fruit of Acacia nilotica date: 2023 words: 2684 flesch: 45 summary: In comparison to the other fruit concentrates of Acacia nilotica, the 400 g/ml concentration of the Acacia nilotica fruit extract exhibits considerable DPPH free radical scavenging activity of 99.85 percent as shown in table no. 3. In this assay, 0.1 ml of test solution of Acacia nilotica fruit extract of different concentrations (100 g/ml, 200 g/ml, and 500 g/ml produced in methanol) and 0.9 ml of bovine serum albumin (5 percent aqueous solution) were taken in different test tubes. keywords: acacia; activity; dpph; extract; fruit; inhibition; nilotica cache: ijpds-3611.pdf plain text: ijpds-3611.txt item: #21 of 77 id: ijpds-3613 author: Jacson, Janice title: Depression among cancer survivors – An untold story date: 2023 words: 3885 flesch: 50 summary: Mandumpala Depression among cancer survivors Vol 1 | Issue 3 | Oct - Dec 2022 Indian J Pharm Drug Studies | 79 Review Article Depression among cancer survivors – An untold story Janice Jacson Mandumpala From, Department of Pharmacy Practice, Nirmala College of Pharmacy, Kerala, India Correspondence to: Janice Jacson Mandumpala, Pharm D intern, Department of Pharmacy Practice, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, Kerala, India. Multi-morbidities, being female, pre-existing psychological illness are few among risk factors that intensify the course of depression among cancer survivors. keywords: breast; cancer; cancer survivors; depression; patients; screening; survivors; treatment cache: ijpds-3613.pdf plain text: ijpds-3613.txt item: #22 of 77 id: ijpds-3619 author: Jacson, Janice; Sebastian, Stephy title: Barriers to Hospital Pharmacy Information System – An emerging concern date: 2023 words: 2912 flesch: 52 summary: This review article focuses on various barriers in hospital pharmacy information systems. This review aims to provide the importance of information systems and implement them across various hospitals. keywords: healthcare; hospital; information; patient; pharmacy; study; system; technology cache: ijpds-3619.pdf plain text: ijpds-3619.txt item: #23 of 77 id: ijpds-3645 author: Kumar, Akhil; Jacson, Janice title: Potential effects of excessive Energy drinks consumption in young people on long-term cardiovascular risks date: 2023 words: 3252 flesch: 47 summary: One of the prominent issues being considered is the link between the risk of developing cardiovascular diseases and energy drink consumption. In the long term, the children and the youth are vulnerable to the dangers of energy drink consumption. keywords: caffeine; consumption; drinks; effects; energy; energy drinks; risk cache: ijpds-3645.pdf plain text: ijpds-3645.txt item: #24 of 77 id: ijpds-3650 author: Baby John, Martin; Rose MS, Alasandra; Jacson, Janice title: Over-the-counter medicine abuse – A pharmacist’s emerging responsibility date: 2023 words: 3524 flesch: 59 summary: This review gives knowledge on the barriers faced by pharmacists in OTC medication abuse and how it can be controlled and managed effectively. One of the main notable reasons for OTC medication abuse is an increase in access to medications [11,12]. keywords: abuse; counter; drug; medications; otc; otc medications; patients; pharmacists cache: ijpds-3650.pdf plain text: ijpds-3650.txt item: #25 of 77 id: ijpds-3688 author: Jacson Mandumpala, Janice title: Medication Reconciliation - A patient safety strategy date: 2023 words: 2986 flesch: 41 summary: This review summarizes a brief review about what is patient safety, and the patterns of employing medication reconciliation in different clinical scenarios that is the emergency department, in transitions of care and in geriatric care. Key words: Medication reconciliation, Patient safety, Emergency department, Geriatric care, Clinical pharmacists edication reconciliation has the potential to reduce significant morbidity and mortality. keywords: care; drug; hospital; medication; patient; pharmacy; reconciliation; safety cache: ijpds-3688.pdf plain text: ijpds-3688.txt item: #26 of 77 id: ijpds-3747 author: Maryam, Zahra; Ahmad , Ausaf title: Comprehensive analysis and critical review of randomized clinical trials on safety profiling of Hydroxychloroquine and Belimumab date: 2023 words: 4625 flesch: 53 summary: This comprehensive review is aimed at analyzing the safety profiles of two widely used drugs for SLE Ie HCQ and Belimumab. The present review is aimed at analyzing the safety profiles of HCQ and Belimumab by the critical review as HCQ was recently used in the global pandemic of covid-19 and recent data is available on HCQ safety profiling. keywords: belimumab; disorders; effects; hcq; lupus; ratio; results; risk; safety; sle; trials cache: ijpds-3747.pdf plain text: ijpds-3747.txt item: #27 of 77 id: ijpds-3748 author: Ahmad , Ausaf; Maryam, Zahra title: Development and validation of novel stability indicating RP HPLC Method for quantitative Estimation of Empagliflozin in Tablets date: 2023 words: 3661 flesch: 50 summary: Jardiance, Glyxambi, Synjardy, and Synjardy XR are examples of Empagliflozin tablets [7-10]. The validation is important as Drug regulatory governing bodies play a vital role and have placed emphasis on drug manufacturing companies to offer comprehensive information regarding the process for the validation of analytical methods C mailto:zahra.maryam489@gmail.com Ahmad et al RP-HPLC Method Validation of Empagliflozin keywords: empagliflozin; hplc; method; mobile; phase; results; solution; study; validation cache: ijpds-3748.pdf plain text: ijpds-3748.txt item: #28 of 77 id: ijpds-3844 author: Preeti Shanbag; Ramdas Bhat; Sweta Prabhu; AR Shabaraya title: Screening of antidepressant activity of nelumbo nucifera flower extract in mice date: 2023 words: 2651 flesch: 57 summary: Shanbhag et al. nelumbo nucifera flower extract in mice Vol 1 | Issue 3 | Oct – Dec 2022 Indian J Pharm Drug Studies | 108 Original Article Screening of antidepressant activity of nelumbo nucifera flower extract in mice Preeti Shanbhag1, Ramdas Bhat2, Sweta Prabhu3, AR Shabaraya4 From, 1PG Scholar, Department of Pharmacology, 2Assistant Professor, Department of Pharmacology, 3PG Scholar, Department of Pharmaceutics, 4Principal and Professor, Srinivas College of Pharmacy, Valachil, Mangalore, India Corresponding to: Ramdas Bhat, Assistant Professor, Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Screening of antidepressant activity of nelumbo nucifera flower extract in mice. keywords: extract; nelumbo; nucifera; test cache: ijpds-3844.pdf plain text: ijpds-3844.txt item: #29 of 77 id: ijpds-3858 author: N, Varshini; M M, Himasvi; Bhat, Ramdas; A R Shabaraya title: Exploring the Novel Norovirus: A Comprehensive Study and Overview date: 2023 words: 2895 flesch: 54 summary: Norovirus is spread through contaminated food or water, close contact with infected individuals, or by touching contaminated surfaces and then ingesting the virus. Norovirus also triggers an immune response in the body, which can further contribute to inflammation and damage of the small intestine. keywords: contact; food; gastroenteritis; infection; norovirus; people; spread; surfaces cache: ijpds-3858.pdf plain text: ijpds-3858.txt item: #30 of 77 id: ijpds-3865 author: Jacson, Janice title: Ceftriaxone Resistance – A caution for judicial antibiotic use date: 2023 words: 4697 flesch: 47 summary: This review summarizes the advent of ceftriaxone resistance among various organisms across the globe. Additionally, a molecular analysis of Salmonella isolates with ceftriaxone resistance has demonstrated a higher production of the CMY-2 and the CTX- M-3 beta-lactamases [11]. keywords: aeromonas; antibiotic; antimicrobial; ceftriaxone; cephalosporins; drug; gonorrhoeae; infections; neisseria; resistance; salmonella cache: ijpds-3865.pdf plain text: ijpds-3865.txt item: #31 of 77 id: ijpds-3890 author: Osunga, Salome; Amuka, Omari; Machocho, Alex; Getabu, Albert; Onani, Martin title: Some members of genus Cassia (Senna): Their Ethnobotany, Potency and Prospects of Drug discovery date: 2023 words: 13719 flesch: 62 summary: Osunga et al. Their Ethnobotany, Potency and Prospects of Drug discovery Vol 2 | Issue 2 | Apr – Jun 2023 Indian J Pharm Drug Studies | 43 N N O N H Cl O 1 H3C CH3 COOHH3CCH3 HO H3C CH3 2 OH HO OHO O O O HO OH OH OH OH HO OH OH HO O 3 4 5 O O HO OH O OH OH O HO OH OH O O H3C HO OH OH O HO OH O O O O O HO HO OH OH 6 9 HO HO OH O 7 8 O HO HO O HO HO O OH OO O OH OH O OH OH HO O HO 10 11 OOH HO O OH OH OH OOH HO O OH 12 13 Osunga et al. keywords: 2020; activities; activity; africa; antioxidant; bark; cassia; compounds; discovery; diseases; drug; et al; ethnobotany; extracts; h o; indian; indian j; int; int j; issue; j pharm; jun; leaves; med; o ho; o o; osunga; phytochemical; plant; potency; prospects; res; review; roots; sci; seeds; senna; skin; species; studies; vol cache: ijpds-3890.pdf plain text: ijpds-3890.txt item: #32 of 77 id: ijpds-3902 author: Viresh K Chandur; Shabaraya A, Ramakrishna title: Characterization of Liquid Oral Containing Lycopene Phytosomes for Improved Absorption date: 2023 words: 3056 flesch: 51 summary: Chandur & Shabaraya A Containing Lycopene Phytosomes for Improved Absorption Vol 2 | Issue 2 | Apr – Jun 2023 Natural or synthetic phospholipids, such as phosphatidylcholine, were obtained from Hi media, aprotic R mailto:viresh.chandur2009@gmail.com Chandur & Shabaraya A Containing Lycopene Phytosomes for Improved Absorption Vol 2 | Issue 2 | Apr – Jun 2023 keywords: drug; liquid; lycopene; oral; phytosomes; studies; suspension cache: ijpds-3902.pdf plain text: ijpds-3902.txt item: #33 of 77 id: ijpds-3904 author: Queeny Wilcy Noronha; Thanshifa Fathima; Bhat, Ramdas; A R Shabaraya title: Current and Emerging Pharmacotherapies for Zika Virus: A Comprehensive Review date: 2023 words: 3276 flesch: 60 summary: Although other arboviral and non-arboviral conditions might also present with same symptoms, a laboratory confirmation of Zika virus infection is necessary [23]. The risk of congenital deformities following Zika virus infection during pregnancy is unknown; it is estimated that 5-15% of babies born to mothers who contracted the virus while pregnant show signs of Zika-related problems. keywords: health; infection; journal; medicine; oct; research; review; virus; zika; zikv cache: ijpds-3904.pdf plain text: ijpds-3904.txt item: #34 of 77 id: ijpds-3935 author: Shanbhag, Preeti; Bhat, Ramdas; A R Shabaraya title: The Potential of siRNA-Mediated Oncogene Silencing in Cancer Therapy: An Overview of Pharmacogenomics Strategies date: 2023 words: 4055 flesch: 54 summary: Oncogenes, which are genes that promote the growth and proliferation of cancer cells, have been discovered as promising targets for siRNA-mediated gene silencing in cancer therapy [2]. An overview of the present status of siRNA-mediated oncogene silencing for cancer therapy will be given in this thorough review. keywords: cancer; clinical; delivery; drug; sirna; therapies; therapy; treatment cache: ijpds-3935.pdf plain text: ijpds-3935.txt item: #35 of 77 id: ijpds-3960 author: Viresh K Chandur; Ramakrishna Shabaraya A title: Spectrophotometric Characterization of lycopene Phytosomes from Fruit Peels of Lycopersicum esculentum date: 2023 words: 2971 flesch: 57 summary: Determination of λmax Figure 1: Determination of λmax of Lycopene form Tomato Peel extract. Non-destructive Measurement of Fresh Tomato Lycopene Content and Other Physicochemical Characteristics Using Visible-NIR Spectroscopy, J. Agric. keywords: cm-1; determination; extract; ftir; lycopene; studies; tomato cache: ijpds-3960.pdf plain text: ijpds-3960.txt item: #36 of 77 id: ijpds-3988 author: Bhat, Ramdas; Hemalatha C H; A R Shabaraya title: Exploring the protective effects of aqueous extracts of Ruta Chalepensis Linn. On drug induced seizures in animal models date: 2023 words: 3235 flesch: 60 summary: Results: In strychnine induced convulsion test the onset of seizure was significantly delayed in the animals treated with Ruta Chalepensis Linn leaf aqueous extract at 750mg/kg. Conclusion: As a result of foregoing Ruta Chalepensis Linn leaf aqueous extract has considerable diuretic activity at higher doses. keywords: aerc; chalepensis; dose; linn; ruta; seizures; strychnine cache: ijpds-3988.pdf plain text: ijpds-3988.txt item: #37 of 77 id: ijpds-4004 author: Jacson, Janice title: A case report on tricyclic antidepressant induced increased blood pressure date: 2023 words: 1719 flesch: 48 summary: Administration of tricyclic antidepressants that cause raised blood pressure becomes particularly important in resistant hypertension cases. Although dietary sodium restriction is an important aspect in the control of blood pressure. keywords: blood; patient; pressure; tablet cache: ijpds-4004.pdf plain text: ijpds-4004.txt item: #38 of 77 id: ijpds-4051 author: Jacson Mandumpala, Janice title: PRECISION MEDICINE AND CLINICAL PHARMACISTS date: 2024 words: 4383 flesch: 41 summary: Figure 1 – Evolving precision medicine techniques for cancer treatment Ethical Issues in precision medicine Precision medicine bases disease treatment and prevention on a patient's unique gene, environmental, and lifestyle variations. The Clinical Pharmacy Advocacy Group emphasizes the need for improved training for chemists in practice as well as students to take precision medicine into account. keywords: cancer; data; drug; medicine; patient; pharmacists; precision; precision medicine; role; treatment; vol cache: ijpds-4051.pdf plain text: ijpds-4051.txt item: #39 of 77 id: ijpds-4052 author: Utpal Bhui; Subhajit Sarkar; Joy Das; Indra Kumar Ghoshal; Abhik Saha; Bimlesh Kumar title: Unraveling the Enigma of Anti-Tubercular Drug-Induced Vitamin B6 Deficiency and its Role in Provoking Convulsive Seizures: A Revelatory Case Report date: 2023 words: 1812 flesch: 51 summary: 2. Tesfahuneygn G, Medhin G, Legesse M. Adherence to Anti- tuberculosis treatment and treatment outcomes among tuberculosis patients in Alamata District, northeast Ethiopia. Now, as a result of an unfavorable drug reaction to anti-tubercular medications, the patient had acquired acute hepatitis and convulsive seizuresdue to vitamin B6 deficiency. keywords: deficiency; drug; hepatotoxicity; patient; tuberculosis; vitamin cache: ijpds-4052.pdf plain text: ijpds-4052.txt item: #40 of 77 id: ijpds-4063 author: Thrupthi P Rai; Karunakar Hegde; A R Shabaraya title: A brief review on Pharmacological potential of Nephelium lappaceum L date: 2023 words: 3067 flesch: 49 summary: Key words: Nephelium lappaceum L., Traditional, Phytochemical, Malay-Indonesian, Health he fruit known as Nephelium lappaceum L. is a member of the Sapindaceae family and is indigenous to tropical areas including Indonesia, China, India, Australia, Malaysia, Mexico, and Thailand. CONCLUSION Nephelium lappaceum L., a member of the sapindaceae family and commonly referred to as Rambutan, has been utilized for generations in traditional medicine. keywords: activity; extract; fruit; lappaceum; nephelium; nephelium lappaceum; peel; rambutan cache: ijpds-4063.pdf plain text: ijpds-4063.txt item: #41 of 77 id: ijpds-4067 author: B M Thejaswini; S, Satish; Ramkrishna Shabaraya A title: A review on Pharmacological potential of Solanum nigrum: Pharmacological review on Solanum nigrum date: 2023 words: 5729 flesch: 50 summary: The results of the present study provide clear evidence of defence provided by Solanum nigrum extract against lead acetate induced toxicity in brains of albino mice [30]. Hepatoprotective activity of Solanum nigrum extracts on chemically induced liver damage in rats. keywords: activity; compounds; extract; fruits; leaves; nigrum; plant; properties; review; seeds; solanum; solanum nigrum cache: ijpds-4067.pdf plain text: ijpds-4067.txt item: #42 of 77 id: ijpds-4072 author: Dsouza, Vinisha Seema title: An update on the ayurvedic herb Centella asiatica date: 2023 words: 4425 flesch: 51 summary: A review on ayurvedic herb Centella asiatica An update on the ayurvedic herb Centella asiatica Ashoka Shenoy M1, Vinisha Seema Dsouza2, Ramkrishna Shabaraya A3 From 1Assi. keywords: acid; activity; anti; antioxidant; asiatica; centella; centella asiatica; effect; extract; plant; rats cache: ijpds-4072.pdf plain text: ijpds-4072.txt item: #43 of 77 id: ijpds-4099 author: Sonia, Sonia gaonkar title: A Brief Review on Pharmacological Potential of Brassica oleracea sprouts date: 2023 words: 2958 flesch: 56 summary: The anti-cancer and antioxidant properties of broccoli sprouts have drawn the most interest and have been the subject of substantial research in recent years. The current study shows that broccoli sprouts are an excellent source of natural antioxidants keywords: activity; brassica; brassica oleracea; broccoli; italica; oleracea; potential; review; sprouts cache: ijpds-4099.pdf plain text: ijpds-4099.txt item: #44 of 77 id: ijpds-4107 author: Supriya Mhamane; Yogesh Shinde title: In-vitro anti-solar activity of peel of Malus domestica date: 2024 words: 1600 flesch: 67 summary: Pawar D. B. et al, “Study on anti-solar activity of ethanolic extract of leaves of ipomoea batatas linn”, World Journal of Pharmaceutical Research 2014; 3(5):382-386. In-vitro anti-solar activity of peel of Malus domestica. keywords: activity; domestica; malus cache: ijpds-4107.pdf plain text: ijpds-4107.txt item: #45 of 77 id: ijpds-4110 author: Sanjay Sukumar Saralaya title: An overview of solvent-free and solvent/s-involved phosphorylation to synthesize Zoledronic acid date: 2023 words: 4431 flesch: 64 summary: ynthesis of Zoledronic acid Z involves the reaction of an acid derivative (2) or its salt (3) with selective p-reagent/s {phosphoric acid (H3PO4), phosphorous acid (H3PO3), phosphorous trichloride (PCl3), phosphorous oxychloride (POCl3), triphosgene, mesyl chloride, etc} in the presence of suitable solvent/s or in the absence of solvent at a suitable temperature. Hu W., et al, in 2002, had illustrated the condensation of key starting material 1-H-imidazole (1) with ethyl-chloroacetate (4) and then hydrolyzed to isolate (3). keywords: acid; h3po3; pcl3; phosphorylation; solvent; yield; zoledronic cache: ijpds-4110.pdf plain text: ijpds-4110.txt item: #46 of 77 id: ijpds-4117 author: Mhamane, Supriya; Adat, Priyanka title: In-vitro Anti-Diabetic activity of leaves of Cicer arietinum date: 2024 words: 1933 flesch: 52 summary: CONCLUSION These studies conclude that, the ethanolic and hydro-alcoholic extract of leaves of Cicer arietinum shows anti-diabetic activity by alpha amylase inhibition assay. In-vitro anti-diabetic activity of leaves of Cicer arietinum. keywords: activity; amylase; cicer; extract; inhibition cache: ijpds-4117.pdf plain text: ijpds-4117.txt item: #47 of 77 id: ijpds-4118 author: Supriya Mhamane; Priyanka Adat title: In-vitro anti-inflammatory activity of leaves of Cicer arietinum date: 2024 words: 1896 flesch: 50 summary: This study shows that Cicer arietinum leaves anti-inflammatory activity. CONCLUSION Based on this study, it is concluded that the ethanolic and hydro-alcoholic extract of leaves of Cicer arietinum shows anti-inflammatory activity by inhibition of protein denaturation activity further studies were suggested to isolate the active principles responsible for the activity. keywords: activity; cicer; extract; inflammation; inhibition cache: ijpds-4118.pdf plain text: ijpds-4118.txt item: #48 of 77 id: ijpds-4119 author: Mhamane, Supriya; Adat, Priyanka title: In-vitro anti-oxidant activity of leaves of Cicer arietinum date: 2024 words: 1314 flesch: 51 summary: The conclusion of this study shows that, the ethanolic and hydro-alcoholic extract of leaves of Cicer arietinum shows anti-oxidant activity by DPPH free radical scavenging activity. In-vitro anti-oxidant activity of leaves of Cicer arietinum. keywords: activity; cicer; dpph; extract; percentage cache: ijpds-4119.pdf plain text: ijpds-4119.txt item: #49 of 77 id: ijpds-4128 author: Ramdas Bhat; Preeti Shanbhag title: Marburg Virus Disease: Latest Outbreak and Current Research Review date: 2024 words: 2919 flesch: 45 summary: Key words: Marburg virus disease (MVD), viral hemorrhagic fever, Outbreaks, Antiviral therapies, Vaccines. arburg virus disease (MVD) is a severe and often fatal viral illness caused by the Marburg virus (MARV), a member of the Filovirus family [1]. Epidemiology of Marburg Virus Disease The epidemiology of Marburg virus disease (MVD) involves studying its distribution, patterns, and determinants within populations. keywords: disease; doi; marburg; marburg virus; mvd; outbreaks; research; review; virus cache: ijpds-4128.pdf plain text: ijpds-4128.txt item: #50 of 77 id: ijpds-4154 author: Mhamane, Supriya; Kadam, Revati title: Herbal face pack formulation from Citrullus lanatus date: 2024 words: 2061 flesch: 66 summary: Herbal face pack formulation from Citrullus lanatus. Keywords: Citrullus lanatus, Herbal face pack, Rind powder, Humectant, Anti-acne. keywords: evaluation; face; formulation; pack; value cache: ijpds-4154.pdf plain text: ijpds-4154.txt item: #51 of 77 id: ijpds-4194 author: Krisnendu Das; Utpal Bhui; Arghya Majumdar; Sanmoy Karmakar title: Incidence of thrombocytopenia one month after initiation of heparin during hemodialysis: A n observational study date: 2024 words: 3364 flesch: 47 summary: Key words: Contaminated heparin, Oversulfated chondroitin sulphate, Heparin-induced thrombocytopenia, End-stage renal disease, Anti heparin platelet factor 4 antibodies hrombocytopenia, or low platelet count, defined as a platelet count below 150 × 109/L, can be broadly classified as congenital and acquired. All of them had platelet counts checked after starting hemodialysis as per protocol. keywords: age; count; figure; hemodialysis; heparin; hit; patients; platelet; study; thrombocytopenia cache: ijpds-4194.pdf plain text: ijpds-4194.txt item: #52 of 77 id: ijpds-4231 author: Sukumar Saralaya, Sanjay title: An overview of prior patents for the sequential progress in the synthetic approaches of Rasagiline, its salts, crystallographic forms and impurities date: 2024 words: 10244 flesch: 43 summary: Gutman AL, Zaltzman I, Ponomarev V, et al. Process for the preparation of rasagiline and its salts. Sathe DG, Damle SV, Sawant KD, et al. Process for preparation of rasagiline and salts thereof. keywords: acid; alcohol; base; et al; form; hplc; hydrochloride; isopropyl; melting; point; preparation; presence; process; publication; purity; racemic; rasagiline; rasagiline base; salts; sodium; yield cache: ijpds-4231.pdf plain text: ijpds-4231.txt item: #53 of 77 id: ijpds-4279 author: Muskan Altaf Tamboli; Rutuja Ramdas Bhosale; Naziya Ashpak Tamboli title: Natural Immunomodulators: Promising Therapy for Disease Management date: 2024 words: 5505 flesch: 40 summary: Immune response in this type is mediated largely by humoral antibodies (B cell-mediated). These diseases arise because of the emergence of immune responses against self–antigens [6]. keywords: acid; anti; antioxidant; cells; diseases; drug; effects; immune; immunity; immunomodulatory; indian; nutraceuticals; reaction; response; studies; system; tamboli; type cache: ijpds-4279.pdf plain text: ijpds-4279.txt item: #54 of 77 id: ijpds-4323 author: Shrijita Sikdar; Udita Dutta; Ayan Ghosh; Suparna Mondal; Krisnendu Das title: Epilepsy Unveiled: Advances in Understanding, Diagnosis, and Management date: 2024 words: 4495 flesch: 52 summary: Elevated serum concentrations in epilepsy patients are detected in plasma. Despite adequate seizure control, a considerable proportion of epilepsy patients have intractable or drug-resistant epilepsy, necessitating the development of novel medications with better side effects and tolerance profiles, even at the expense of efficacy, when compared to existing antiepileptic therapies. keywords: advances; brain; drug; efficacy; epilepsy; epileptic; indian; mechanisms; onset; people; research; seizures; studies cache: ijpds-4323.pdf plain text: ijpds-4323.txt item: #55 of 77 id: ijpds-4367 author: Annayat Ghuman; Mehar Ghuman; Gupta, Pankaj title: Application of Alternative Medicine as a Curative Therapy of Oral Mucosal Lesions: A Comprehensive Review date: 2024 words: 4185 flesch: 53 summary: This article emphasis the use of various alternative therapies, their advantages, mechanism of actions, side effects and implications in dentistry. When such medicines and related therapies are applied in the dental field, the term holistic dentistry is used. keywords: aloe; cancer; dentistry; effects; gel; honey; medicine; study; therapies; treatment; vera cache: ijpds-4367.pdf plain text: ijpds-4367.txt item: #56 of 77 id: ijpds-4396 author: Bhirich, Nihal; Meknassi, Ghita Salime; Yafout, Mohamed; Elhorr, Hicham; Haj Said, Amal Ait; Mojemmi, Brahim title: A review of plants and essential oils effective as natural remedies against bedbugs date: 2024 words: 5419 flesch: 58 summary: Substances of natural origin such as plant essential oils, which are secondary metabolites derived from the outer glandular cells of the leaves and stems of aromatic plants [12], are one of the treatment alternatives used to combat bedbugs. Essential oils as fumigants for bed bugs (Hemiptera: Cimicidae). keywords: action; bedbugs; camphor; effects; entomol; insecticides; leaves; oils; plants; review; studies; thymol; toxicity; vulgaris cache: ijpds-4396.pdf plain text: ijpds-4396.txt item: #57 of 77 id: ijpds-4398 author: Bhagyashri D Kolekar; Namrata N Gawade; G K Dyade; Nilesh Y Jadhav title: Chemo metric assisted Spectrophotometric Method Development through Quality by design Approach for the estimation of Bilastine and Montelukast sodium in combined solid dosage form date: 2024 words: 5055 flesch: 54 summary: Also some regulatory guidelines have mentioned flexibility of changing analytical method without revalidation if the AQbD approach has been implemented during analytical method development. Development of various pharmaceutical processes including analytical methods by applying Quality by design aids in ensuring the robustness of the method. keywords: bilastine; bse; development; dosage; estimation; hplc; method; mks; montelukast; montelukast sodium; sodium; validation cache: ijpds-4398.pdf plain text: ijpds-4398.txt item: #58 of 77 id: ijpds-4437 author: Bhat, Ramdas; Saleem, Fazeela Mohammed; Shabaraya, AR title: Assessing Self-Medication Practices: A Cross-Sectional Study on Implications and Challenges date: 2024 words: 3298 flesch: 44 summary: While convenience and cost- effectiveness drive self-medication, contrasting concerns about adverse effects and misdiagnosis highlight the imperative for responsible medication practices. The survey gathered data on the reasons why individuals choose to self-medicate, the types of medications they use, the sources of information they rely on, and their awareness of the potential risks and benefits of self-medication. keywords: health; medication; prevalence; respondents; self; study cache: ijpds-4437.pdf plain text: ijpds-4437.txt item: #59 of 77 id: ijpds-4459 author: Bhat, Ramdas; Shanbhag, Preeti title: Emerging Trends in Biomaterials for Cancer Immunotherapy and Genome Editing: A Comprehensive Review date: 2024 words: 6114 flesch: 37 summary: Examples such as Daliyno (tilmesogenecel), Breyanzi (lisocabtagenedarolumab), and Tecartus (breceltinib) utilize a patient's own tumor-infiltrating lymphocytes (TILs) or engineered CAR T-cells to precisely target melanoma, large B-cell lymphoma, and mantle cell lymphoma [8].Cancer Vaccines, including Gvax (rasilmuplasmid), Papillomavirus vaccines (Gardasil, Cervarix), and personalized neoantigen vaccines, stimulate the immune system to identify and eliminate cancer cells, showcasing a personalized treatment approach [9]. __________________________________________________ Correspondence to: Ramdas Bhat, Associate Professor, Dept. of Pharmacology, Srinivas College of Pharmacy, Valachil, Post Farangipete, Mangalore, Karnataka, India-574143. Cancer Vaccines: Biomaterial-based cancer vaccines have emerged as a compelling approach to augment the body immune response against cancer cells [28]. keywords: biomaterials; cancer; cas9; cells; crispr; delivery; editing; gene; genome; genome editing; immune; immunotherapy; target; therapies; vectors cache: ijpds-4459.pdf plain text: ijpds-4459.txt item: #60 of 77 id: ijpds-4483 author: M, Ashoka Shenoy; Mahurkar, Nitin title: Complementary action of ginger as bioenhancers in the treatment of diabetes date: 2024 words: 4430 flesch: 47 summary: RESULTS Diabetic rats treated with glibenclamide and glibenclamide along with ginger extract showed significant reduction in the elevated levels of total cholesterol, triglycerides and LDL cholesterol in comparison to diabetic control group. Results: Diabetic rats treated with glibenclamide and glibenclamide along with ginger extract showed significant (p<0.001) reduction in the elevated levels of total cholesterol, triglycerides and LDL cholesterol in comparison to diabetic control group. keywords: control; diabetes; diabetic; extract; ginger; glibenclamide; group; indian; rats; treatment cache: ijpds-4483.pdf plain text: ijpds-4483.txt item: #61 of 77 id: ijpds-4503 author: Saralaya, Sanjay Sukumar; Hiriyalau, Shashikumar Somashekar title: An overview of prior art disclosures about the synthesis of lamotrigine and a glimpse of its closely related compounds date: 2024 words: 5502 flesch: 57 summary: With an intention to find an industrially feasible route of synthesis to manufacture 1 in high atom economy, Venkanna G, et al., had disclosed a high yield and an improved process than the past referred routes Scheme 2. Venkanna G, Nagender D, Venkateswarlu P, et al. Process for producing 6-(2, 3-dichlorophenyl)-1, 2, 4-triazine 3,5- diamine(Lamotrigine) and identification, characterization of a new N-methyl impurity. keywords: acid; characterization; cl cl; compounds; crystal; drug; et al; lamotrigine; nh2; solvate; studies; synthesis; triazine cache: ijpds-4503.pdf plain text: ijpds-4503.txt item: #62 of 77 id: ijpds-4528 author: Dave, Pallav title: The Role of Pharmacists in Opioid Addiction Management date: 2024 words: 5341 flesch: 53 summary: Strategies to identify patient risks of prescription opioid addiction when initiating opioids for pain: A systematic review. The aim of this review is to explore the role of pharmacists in opioid addiction management including prevention, screening, education, naloxone prescribing, counselling, and referral to treatment resources. keywords: abuse; addiction; management; misuse; opioid; patients; pharmacists; risk; role; treatment cache: ijpds-4528.pdf plain text: ijpds-4528.txt item: #63 of 77 id: ijpds-4564 author: Saralaya, Sanjay Sukumar title: A comprehensive review of disclosures in academic journals regarding the synthesis of Rasagiline and its closely related compounds along with majorbiological activity advancements date: 2024 words: 7832 flesch: 56 summary: Galvão WS & coworkers had reported the kinetic resolution of secondary alcohols (including 60 to isolate the intermediate for R synthesis) using nano-hydrid bio-catalysts [77]. NH2 + .HCl S OO O CH NaOH, TBAB, H 2O NH CH tartaric acid resolution R-R,R tartarate + 3-R,R tartarate avrg yield: 45.0% Racemic oil1 71 ppt Scheme 5: Simple route of Rasagiline synthesis from 1 as per [69]. keywords: ch3 ch3; compounds; coworkers; derivatives; dihydro-1h; disease; drug; inden-1; nh ch; o ch3; rasagiline; synthesis; yn-1 cache: ijpds-4564.pdf plain text: ijpds-4564.txt item: #64 of 77 id: ijpds-4592 author: Shirsath, Nitin Rajendra; Shitole, Rohit; Jagtap, Vaibhavkumar; Sagare, Abhay Ramling; Goswami, Ajaygiri title: Life–Style and Behavioral Changes after COVID-19: A Perspective date: 2024 words: 5325 flesch: 60 summary: After COVID-19 impact of interrupted education was?, (e) What do you think about students’ future, due to COVID-19, and (f) what do you learn from the COVID- 19 pandemic? Figure 4: COVID-19 impact on education Learn from COVID-19 pandemic A common perspective on mental health is that it is a behavioural process that enables individuals to balance their needs with those of their surroundings or with other needs. keywords: changes; covid-19; education; health; impact; india; life; pandemic; participants; people; study; survey cache: ijpds-4592.pdf plain text: ijpds-4592.txt item: #65 of 77 id: ijpds-4594 author: Samajdar, Saptarshi; Samajdar, Debojit title: In silico bioactivity prediction and topical formulation of Piper longum root for skin cancer date: 2024 words: 3840 flesch: 58 summary: ABSTRACT Background: Skin cancer is exceedingly common and the incidence is rising rapidly. Although the mortality rate for skin cancer is not as large as other cancers but still a steady mortality rate around the world remains. keywords: cancer; cream; evaluation; formulation; ligands; longum; piper; samajdar; silico; skin cache: ijpds-4594.pdf plain text: ijpds-4594.txt item: #66 of 77 id: ijpds-4607 author: K, Pruthviraj; B S, Chethan ; T N, Lohith; N S, Dinesh Babu; R, Chandrakumar; Kumar, Mohan ; G, Shivaraja ; K, Sunil title: Synthesis, evaluation of antimicrobial activity, and DFT analysis of 1-(4,5-diphenyl-1H-imidazol-2-yl)naphthalen-2-ol date: 2024 words: 3559 flesch: 51 summary: Pruthviraj et al. Pruthviraj et al. keywords: activity; analysis; diphenyl-1h; evaluation; imidazole; potential; studies; synthesis; yl)naphthalen-2 cache: ijpds-4607.pdf plain text: ijpds-4607.txt item: #67 of 77 id: ijpds-4623 author: Bafna, Harshada Rajendra; Shirsath, Nitin Rajendra; Jagtap, Vaibhavkumar Arun title: A New Path for Drug Delivery by Multiple Unit Pellet System (MUPS) date: 2025 words: 5607 flesch: 50 summary: In medicine, the proportion of drug pellets to cushioning excipients is crucial. Similar therapeutic benefits can be obtained via controlled release capsules, a kind of solid oral formulation that frequently includes a range of coated pellets. keywords: coating; compression; delivery; drug; excipients; mups; pellets; pharmaceutical; release; size; system; tablets; technology; unit cache: ijpds-4623.pdf plain text: ijpds-4623.txt item: #68 of 77 id: ijpds-4638 author: Dyade, G. K. ; Jadhav, R. B.; Repal, Sanket; Uparwad, Shital; Suryawanshi, Prashant; Taware, Aashish ; Khapne, Sonali ; Kokare, Shweta; Dnyaneshwar, Anuse title: QBD Approach and Chemo metric Method Development for the estimation of Metoprolol succinate and Cilnidipine in combined solid dosage form date: 2024 words: 4907 flesch: 50 summary: Also some regulatory guidelines have mentioned flexibility of changing analytical method without revalidation if the AQbD approach has been implemented during analytical method development. Development of several pharmaceutical processes including analytical methods by applying Quality by design assists in ensuring the robustness of the method. keywords: absorbance; analytical; cil; cilnidipine; development; estimation; method; metoprolol; pharmaceutical; qbd; succinate cache: ijpds-4638.pdf plain text: ijpds-4638.txt item: #69 of 77 id: ijpds-4639 author: Singha, Soumyadip; Nayak, Soumyadip; Bishayee, Rahul; Sarkar, Pritam; Ghosh, Priyanka; Dutta, Udita; Mishra, Poulomi title: Decoding Leptin: Unraveling the Role of Leptin Signaling in the BattleagainstObesity date: 2024 words: 5257 flesch: 50 summary: Biochimie. 2012; 94(10):2111-5. doi:10.1016/j.biochi.2012.05.010 8. Izquierdo AG, Crujeiras AB, Casanueva FF, et al. Leptin, obesity, and leptin resistance: where are we 25 years later? Liao GY, An JJ, Gharami K, et al. keywords: doi; energy; et al; fat; leptin; levels; obese; obesity; receptor; resistance; role; signaling; studies; weight cache: ijpds-4639.pdf plain text: ijpds-4639.txt item: #70 of 77 id: ijpds-4688 author: Umarkar, Mohit J.; Jibhkate, Pawan V.; Thakare, Payal G.; Banarase, Nilesh B.; Gabhane, Koshish B.; Salode, Vikrant L. title: Alum-based Herbal Handwash: Formulation and Evaluation Study date: 2024 words: 4165 flesch: 62 summary: Add an equal volume of test solution. Bial’s orcinol test (for pentose sugars): To boil Bial’s reagent, add a few drops of test solution. keywords: alum; extract; foam; formulation; handwash; lemon; solution; test; water cache: ijpds-4688.pdf plain text: ijpds-4688.txt item: #71 of 77 id: ijpds-4715 author: R, Dr. Reshma; K, Dr. Ajnas title: A case of pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection date: 2024 words: 2739 flesch: 47 summary: As a result, the onset is unlikely to occur again, while PANDAS symptoms may continue to appear on a regular basis.5 The National Institute of Mental Health’s (NIMH) criteria for PANDAS includes: 6 1. Some children may be unable to function in social or academic settings due to PANDAS symptoms. keywords: autoimmune; case; disorder; infection; ocd; pandas; patient; symptoms cache: ijpds-4715.pdf plain text: ijpds-4715.txt item: #72 of 77 id: ijpds-4724 author: Savvaser, Spandana; Poojary, Rakshitha; Habibullah, Soubiya Mahnoor; M, Ashoka Shenoy title: EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF Phyllanthus niruri LEAVES IN MICE date: 2024 words: 4490 flesch: 57 summary: The anxiety disorders are mainly classified as panic disorder, generalized anxiety disorder, post-traumatic stress disorder, obsessive– compulsive disorder, social phobia, and specific phobias.[13] Among anxiety disorders, panic disorder (10.3%), social phobia (2.7%), and generalized anxiety disorder (2.2%) are particularly common.[14] The symptoms and the disorders following anxiety can be due to the impaired regulation of the central nervous system. Various theories, including psychodynamic, psychoanalytic, and genetic perspectives, have been proposed to explain the etiology of anxiety disorders. keywords: animals; anxiety; arm; dark; entries; extract; light; mice; niruri; number; phyllanthus; time cache: ijpds-4724.pdf plain text: ijpds-4724.txt item: #73 of 77 id: ijpds-4738 author: Patil, Rutik Nitin; Deore, Bhupendra L; gurav, Darshan Ganesh title: Analytical Method Development and Validation date: 2024 words: 5388 flesch: 42 summary: Evaluation and application of best practice in analytical method validation. In the process of finding, developing, and producing medications, analytical methods are crucial. keywords: analysis; analyte; detection; development; drug; hplc; limit; method; method development; pharmaceutical; samples; technique; test; validation cache: ijpds-4738.pdf plain text: ijpds-4738.txt item: #74 of 77 id: ijpds-7624 author: Bharti, Manu ; Bhardwaj, Anjali ; Parveen, Neha ; Gupta, Ashwani title: Evaluation of hair growth potential of Angustifolia leaves hair gel in rats date: 2025 words: 3446 flesch: 57 summary: Hair growth studies were performed on Wistar rats by evaluating both qualitative (initiation and completion of hair growth) and quantitative parameters (hair length, follicle count, and histological observations). Table 3: Effect of EESA gel formulation on hair growth initiation, completion time, and growth of hair length *p < 0.05 significant when compared to control (ANOVA followed by Dunnett’s test values are mean ± SEM Figure 3: Hair growth on 0, 10, 20 and 30th day using HG 2 Further, hair follicles, skin thickness, and color were assessed. EESA 2.5% (HG1) showed visible changes from day 20, while EESA 5% (HG2) showed early effects by day 10. keywords: anagen; angustifolia; control; eesa; gel; growth; hair; minoxidil; rats; senna cache: ijpds-7624.pdf plain text: ijpds-7624.txt item: #75 of 77 id: ijpds-7762 author: Agrawal, Rashmi ; Kulkarni, Meghashyama title: Application of Artificial Intelligence in drug discovery, designing, clinical trials and repurposing date: 2025 words: 5185 flesch: 55 summary: CONCLUSION Artificial Intelligence has a crucial role in the various stages of drug development, ranging from drug discovery, design, formulation, clinical trials, repositioning, and up to the final market introduction. Agrawal and Kulkarni AI Applications in Drug Discovery and Development Online First Indian J Pharm Drug Studies | 1 Review Article Application of Artificial Intelligence in drug discovery, designing, clinical trials and repurposing Rashmi Agrawal1, Meghashyama Kulkarni2 From, 1Consultant, Devmata Hospital, Bhopal, Madhya Pradesh, India, 2Consulting Oral Pathologist, Bengaluru, Karnataka, India ABSTRACT Drug development, right from discovery, designing, and repurposing, along with various phases to clinical trials, is a complex and time- consuming process that traditionally relies on the experience of labor forces, along with incessant trial-and-error experimentation. keywords: data; development; discovery; doi; drug; drug discovery; et al; intelligence; learning; pharmaceutical; target; toxicity; trials cache: ijpds-7762.pdf plain text: ijpds-7762.txt item: #76 of 77 id: ijpds-7913 author: Agrawal, Rashmi title: Therapeutic Drug Monitoring (TDM): A Necessity in Critical Care and Transplant Settings date: 2025 words: 3549 flesch: 38 summary: For therapeutic drug monitoring (TDM) to be effective, the concentration of a medication must be assessed in several physiological fluids. In the last ten years, the theory, practice, and clinical relevance of therapeutic drug monitoring (TDM) have significantly evolved due to the advent of widely accessible and technically proficient modelling, simulation, and dosing software tools [3]. keywords: care; clinical; dosage; dosing; drug; drug monitoring; monitoring; patients; pharmacokinetic; post; tacrolimus; tdm; toxicity; transplant; trough cache: ijpds-7913.pdf plain text: ijpds-7913.txt item: #77 of 77 id: ijpds-7991 author: Gandrathi, Srujana ; kumar, Padamatini Naveen ; Baru, Chandrasekhara Rao ; DESAI, SUSHMA; Shiroja, M. ; swetha, Raaga title: Designand Development of Press Coated Pulsatile Release of KetoprofenTablets date: 2025 words: 3746 flesch: 55 summary: RESULTS & DISCUSSION Using various polymers (HPMC E5, HPMC E15, Xanthan gum) and a combination of synthetic and natural polymers (HPMC E5 and xanthan gum (1:1 and 3:1), HPMC E5 and HPMC E15 (1:1), HPMC E15 and xanthan gum (1:1, 2:1, and 3:1)), the current study aims to formulate and evaluate Ketoprofen pulsatile tablets. Recent trends in pulsatile drug delivery systems-A review. keywords: delivery; drug; formulation; hpmc; ketoprofen; pulsatile; studies; tablets cache: ijpds-7991.pdf plain text: ijpds-7991.txt