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Vol 3 | Issue 1 | Jan – Mar 2024                                                                         Indian Journal Pharm Drug Studies | 29  

Original Article 

Complementary action of ginger as bioenhancers in the treatment of diabetes 

Ashoka Shenoy M1, Nitin Mahurkar2 

From, 1Department of Pharmacology, Srinivas College of Pharmacy, Mangalore, 2Professor & Principal, Department of 

Pharmacology, HKES’s MTRIPS, Kalaburagi. 

ABSTRACT 

Aim and objective: To evaluate the role of Zingiber officinale extract along with glibenclamide on lipid profile in alloxan & 

streptozotocin induced diabetes mellitus in rats. Method and Materials: The diabetes in rats was induced by the administration of 

intraperitoneal injection of alloxan (100mg/kg) and streptozotocin (65 mg/kg). After 2 days of injection, the hyperglycaemic rats 

(glucose level > 200 mg/dl) were separated and divided into five groups consisting of six rats in each group. The oral treatment was 

started from the same day for next three weeks. On 21st day the blood was collected for biochemical estimations by retro orbital 

puncture. The serum was obtained by centrifuging the blood samples at 3000 rpm for 10 m and used for estimation of SGPT, SGOT, 

SOD and CAT. Results: Diabetic rats treated with glibenclamide and glibenclamide along with ginger extract showed significant 

(p<0.001) reduction in the elevated levels of total cholesterol, triglycerides and LDL cholesterol in comparison to diabetic control 

group. The effect was less significant in rats treated with only ginger extract (p<0.01). Also, the HDL level was significantly 

(p<0.001) increased in glibenclamide and glibenclamide along with ginger treated group. Serum biomarkers such as SGPT and SGOT 

level were significantly elevated in diabetic control group. The  animals treated with glibenclamide and glibenclamide in combination 

with ginger extract, the elevated SGPT and SGOT levels were normalised significantly (p < 0.001, p < 0.01 respectively) as compared 

to the diabetic control. From antioxidant studies, it was found that alloxan and streptozotocin induced diabetic control animals showed 

a significant decrease in the levels of SOD and CAT as compared to normal control. The animals treated with glibenclamide and 

glibenclamide + ginger extract combination showed significant increase in CAT and SOD (p<0.01 and p<0.001 respectively) as 

compared to diabetic control. Conclusions: The findings of the study suggest that, ginger shows complementary action with 

glibenclamide in the treatment of diabetes. So it can be considered as a safe supplementary in management of diabetes mellitus. 

Further studies has to conducted, to check whether dosage of glibenclamide can be reduced when it is given along with ginger.  

Key words: Diabetes, Bioenhancer, Ginger, Serum glutamic-oxaloacetic transaminase, Separation of Duty, Common Admission Test. 

he major chronic complications associated with 

diabetes include retinopathy, neuropathy, 

nephropathy, atherosclerotic coronary artery disease 

and peripheral atherosclerotic vascular disease. Besides 

hyperglycemia, several other factors like hyperlipidemia and 

enhanced oxidative stress play a major role in diabetic 

pathogenesis [1]. Diabetes has been known to medical 

sciences longer than any other hereditary metabolic diseases. 

Nevertheless, the existing methods of treatment for this age 

old illness are not completely satisfactory owing to low 

efficacy, associated adverse effects and compliance issues. 

Among the therapies non pharmacologic therapy (e.g. diet, 

exercise and weight loss) remains to be critical component in  

Access this article online 

Received – 06th Jan 2024 

Initial Review – 11th Feb 2024 

Accepted – 26th Feb 2024 Quick Response Code 

diabetes treatment. Dietary management includes the use of 

traditional medicines mainly derived from plants.  

Several herbal preparations are used to treat diabetes, but 

their reported hypoglycemic effects are complex or even 

paradoxical in some cases. Several mechanisms have been 

proposed for the hypoglycemic effect of phytochemical, such 

as inhibition of carbohydrate metabolizing enzymes, 

manipulation of glucose transporters, -cell regeneration and 

enhancing insulin releasing activity. Eugenia jambolana 

inhibits -amylase, -glucosidase, sucrase and increase 

glucose uptake by cells. Also increase insulin secretion and 

inhibit insulinase activity. Momordica charantia inhibits 

glucose-6-phosphatase, fructose-1, 6- biphosphatase and 

stimulates of hepatic glucose-6-phosphate dehydrogenase 

activities [2]. 

__________________________________________________ 

Correspondence to: Ashoka Shenoy M, Associate Professor, 

Department of Pharmacology, Srinivas College of Pharmacy, 

Mangalore, India - 574143. Email: shenoyscp@gmail.com.  

T 

mailto:shenoyscp@gmail.com


Shenoy M & Mahurkar                       Complementary action of ginger as bioenhancers in the treatment of diabetes 

Vol 3 | Issue 1 | Jan – Mar 2024                                                                         Indian Journal Pharm Drug Studies | 30  

The development of new therapies that are able to improve 

glycemia management and even to cure diabetes is of great 

interest. Use of plants for human health care is as ancient as 

human beings themselves India has one of the oldest, richest 

and diverse cultural traditions associated with the use of the 

plants and herbs for human, livestock and plant health [3]. Due 

to change in the lifestyle, the number of people in the world 

with diabetes has increased dramatically over recent years. 

The world is facing an explosive increase in the incidence of 

diabetes mellitus. According to the World Health Organization 

(WHO) estimates, the number of adults with diabetes in the 

world will rise from 135 million in 1995 to 300 million in the 

year 2025, with one-third of affected individuals living in 

India and China alone [4]. 

Herbs are staging a comeback and herbal ‘renaissance’ is 

happening all over the globe. The herbal products today 

symbolize safety in contrast to the synthetics that are regarded 

as unsafe to human. World Health Organization has 

recognized the potential of traditional and folk medicines in 

the management and self-reliance of health care system and 

currently it is encouraging and promoting the traditional 

systems in “National Health Care Programmes” of various 

countries. The World Health Organization has estimated that 

80% of the world's population use botanical medicine for their 

primary healthcare needs. Herbal bioenhancers without 

possessing their own inherent pharmacological activity of 

their own but when coadministered with other drugs, enhances 

their bioavailability and hence efficacy.  

The interest for bioenhancers arises because of 

chemotherapeutic agents which are poorly bioavailable, 

administered for prolong periods, toxic and expensive. One of 

the unique ways to achieve reduction in drug dosage and 

therefore drug toxicity & cost is to increase drug 

bioavailability. The present pharmaceutical research is more 

concerned with different aspects of exploring new chemical 

molecules having new modes of action. New drug 

development technologies were developed from the 

economics of treatment. There is a revolutionary shift in the 

way medicines are administered due to recent developments 

for enhancing the bioavailability. The present global focus is 

on methods aimed at reducing drug treatment period leading 

to decrease in drug treatment cost. The reduction in cost of 

therapy will make more affordable for financially challenged 

wide sections of society [5]. 

MATERIALS & METHODS 

Experimental Animals: Wistar rats (180 to 200 g) of either 

sex were used for this study. They were maintained under 

standard conditions (temperature 22±2oC, relative humidity 

60±5% and 12 h light/dark cycle).The animals were housed in 

sanitized polypropylene cages containing sterile paddy husk as 

bedding. They had free access to standard pellet diet and water 

ad libitum. All the animals received humane care according to 

the criteria outlined in the “Guide for the Care and Use of 

Laboratory Animals” prepared by the “National Academy of 

Sciences” and published by the “National Institute of Health”. 

All the procedures were performed in accordance with 

Institutional Animal ethics committee constituted as per the 

direction of the committee for the purpose of control and 

supervision of experiments on animals (CPCSEA), under 

ministry of animal welfare division, Government of India, 

New Delhi, India. 

Chemicals: All the chemicals and reagents used were of 

analytical grade and were purchased from Yarrow Chem, 

Loba Chem, Himedia and Agappe diagnostics. 

METHODOLOGY 

Preparation of aqueous extract of gingiber officinale 

rhizomes: Aqueous ginger extract was prepared from locally 

available ginger rhizomes.  Ginger rhizomes (500g) were 

peeled on crushed ice and were cut into small pieces and 

homogenized in750 ml cold, 0.9% NaCl solution and 250 mL 

ice cold water to make the volume up to 1000 ml. The 

homogenization was carried out in a blender for 12 m. The 

homogenized mixture was filtered three times through cheese 

cloth. The filtrate was centrifuged at 2000 rpm for 10 m and 

the clear supernatant fraction was separated and volume made 

up to 1000 ml with normal saline. The concentration of this 

ginger preparation was considered to have 500 mg / ml on the 

basis of the weight of the starting material. The extract was 

stored in sample tubes at -4°C until fed to animals [6]. 

Routes of drug admistration: The vehicle, standard drug and 

test drugs were administered orally with the help of an oral 

feeding needle. 

Pharmacological Screening 

Alloxan induced anti-diabetic activity: Fasting blood 

glucose was determined after depriving food for 16 h with free 

access to drinking water. Hyperglycemia was induced by 

single i.p injection of 100 mg/kg of alloxan monohydrate in 

normal saline. After 2 days of alloxan injection, the 

hyperglycemic rats (glucose level > 200 mg/dl) were 

separated and divided into five groups consisting of six rats in 

each group. The oral treatment was started from the same day 

except diabetic control groups for three weeks. The animals 

had free access to feed with water ad libitum. 

Experimental design: Animals were randomly divided into 5 

groups of 6 each. The different groups were assigned as 

follows: Group I - Vehicle control (normal saline), Group II 

- Diabetic control (alloxan100mg/Kg), Group III - Diabetic 

rats + ginger extract (500mg/kg), Group IV - Diabetic rats + 

glibenclamide (5mg/Kg), Group V - Diabetic rats + 

glibenclamide (5 mg/Kg) + ginger extract (500mg/Kg) 



Shenoy M & Mahurkar                       Complementary action of ginger as bioenhancers in the treatment of diabetes 

Vol 3 | Issue 1 | Jan – Mar 2024                                                                         Indian Journal Pharm Drug Studies | 31  

Streptozotocin induced anti-diabetic activity: Fasting blood 

glucose was determined after depriving food for 16 h with free 

access to drinking water. Hyperglycemia was induced by 

single i.p injection of 65 mg/kg of STZ in citrate buffer, 

freshly prepared and injected immediately to prevent 

degradation. After 2 days of streptozotocin injection, the 

hyperglycemic rats (glucose level > 200 mg/dl) were 

separated and divided into five groups consisting of six rats in 

each group. The oral treatment was started from the same day 

except diabetic control groups for three weeks. The animals 

had free access to feed with water ad libitum.  

Experimental design: Animals were randomly divided into 5 

groups of 6 each.  The different groups were assigned as 

follows: Group I: Vehicle control (normal saline), Group II:

 Diabetic control (streptozotocin 65mg/Kg), Group III: 

Diabetic rats + ginger extract (500mg/kg), Group IV: 

Diabetic rats + glibenclamide (5mg/Kg), Group V: Diabetic 

rats + glibenclamide (5 mg/Kg) + ginger extract (500mg/Kg). 

Collection of blood and serum samples: The above 

treatment was carried out in each group of animals for 21days. 

On 21st day the blood was collected for biochemical 

estimations by retro orbital puncture. The serum was obtained 

by centrifuging the blood samples at 3000 rpm for 10 m and 

they were used for estimation of SGPT, SGOT by using a 

corresponding kit from Agappe Diagnostics Pvt. Ltd. The 

intensity of the colored complex formed after treating with 

these reagents was estimated in semi-auto analyzer. 

The parameters studied were as follows: 

 Biochemical parameters such as 

a. Serum lipid profile  

b. Serum glutamic pyruvate transamase (SGPT) 

c. Serum glutamic oxaloacetate transamase (SGOT) 

 Endogenous antioxidant parameters include 

a. Superoxide dismutase (SOD) 

b. Catalase (CAT) 

Antioxidant Parameters 

Tissue Preparation 

 Animals were sacrificed by cervical dislocation.  

 The whole liver was perfused in situ with ice-cold saline, 

dissected out, blotted dry and immediately weighed. 

 A liver homogenate was prepared with ice-cold saline-

EDTA. 

 The homogenate was centrifuged at 10,000 rpm for 10 m 

and the pellet discarded. The supernatant was again 

centrifuged at 20,000 rpm for 1 hour.  

Statistical analysis: Results of biochemical estimation were 

reported as mean ± S.E.M. The total variation present in a data 

was analyzed by one way analysis of variance (ANOVA).  

RESULTS 

Diabetic rats treated with glibenclamide and glibenclamide 

along with ginger extract showed significant reduction in the 

elevated levels of total cholesterol, triglycerides and LDL 

cholesterol in comparison to diabetic control group. The effect 

was less significant in rats treated with only ginger extract. 

Also, the HDL level was significantly increased in 

glibenclamide and glibenclamide along with ginger treated 

group as summarized in (Table 1 & Table 2). 

Serum biomarkers: After 21days of experiment, serum 

biomarkers such as SGPT and SGOT level were significantly 

elevated in diabetic control group. In animals treated with 

glibenclamide and glibenclamide in combination with ginger 

extract, SGPT and SGOT levels were decreased significantly 

as compared to the diabetic control as shown in (Table 3).  

Antioxidant parameters: From antioxidant studies, it was 

found that both alloxan and STZ induced diabetic control 

animals showed a significant decrease in the levels of SOD 

and CAT as compared to normal control. Animals treated with 

glibenclamide and glibenclamide + ginger extract combination 

showed significant increase in CAT and SOD as compared to 

diabetic control as shown in (Table 4).  

Table 1: Effect of ginger, glibenclamide and their combination on serum lipid profile in alloxan induced diabetic rats 

Group Cholesterol 

(mg/dl) 

Triglyceride 

(mg/dl) 

HDL (mg/dl) LDL (mg/dl) 

Normal control 62.12±0.84 62.02±1.25 47.32±1.30 42.20±0.14 

Diabetic control 6.13±1.57 89.45±0.35 20.18±0.34 97.24±0.37 

Ginger Extract (500 mg/kg) 82.15±0.34* 83.3±0.17* 27.56±0.56* 71.35±0.25* 

Glibenclamide (5 mg/Kg)  60.34±0.47** 74.19±0.78** 33.24±0.25** 66.16±1.65** 

Glibenclamide (5 mg/Kg) + Ginger extract (500 

mg/ Kg) 

56.28±0.67** 64.33±1.26** 39.33±0.58** 57.46±1.07** 

Values are expressed as Mean± S.E.M (n=6). One way ANOVA followed by Dunette’s test. *p<0.01, **p<0.001 when compared 

with diabetic control group. 



Shenoy M & Mahurkar                       Complementary action of ginger as bioenhancers in the treatment of diabetes 

Vol 3 | Issue 1 | Jan – Mar 2024                                                                         Indian Journal Pharm Drug Studies | 32  

Table 2: Effect of ginger, glibenclamide and their combination on serum lipid profile in streptozotocin induced diabetic rats 

Group Cholesterol Triglycerides HDL LDL 

Normal control 66.23±2.15 60.58±0.05 48.51±1.54 43.19±3.21 

Diabetic control 151.5±0.12 110.26±1.69 16.86±8.12 104.31±1.58 

Ginger Extract (500 mg/kg) 118.3±0.25* 98.0±6.18* 31.57±3.51* 87.68±1.95* 

Glibenclamide (5 mg/Kg)  105.61±6.12** 82.84±2.89** 36.85±0.24** 75.21±2.68** 

Glibenclamide (5 mg/Kg) + 

Ginger extract (500mg/ Kg) 

89.88±1.59** 64.42±3.25** 42.19±4.25** 61.32±2.18** 

Values are expressed as Mean ± S.E.M (n=6). One way ANOVA followed by Dunette’s test. *p<0.01, **p<0.001 when compared 

diabetic control group. 

Table 3:  Effect of ginger, glibenclamide and their combination on serum SGPT and SGOT in alloxan and streptozotocin 

induced diabetic rats 

Group 
Alloxan STZ 

SGPT SGOT SGPT SGOT 

Normal control 56.43±1.28 64.52±1.45 58.61±2.65 62.63±3.75 

Diabetic control 142.51±1.95 150.38±1.65 139.48±2.38 148.72±1.05 

Ginger Extract (500 mg/kg) 116.21±3.24 * 123.51±2.43 * 113.45±2.09 * 121.34±1.34 * 

Glibenclamide (5 mg/Kg)  102.81±2.65 ** 98.91±2.85 ** 92.80±2.11 ** 84.64±1.69 ** 

Glibenclamide (5 mg/Kg) + Ginger extract (500 mg/ Kg) 89.38±1.65 ** 87.45±2.25 ** 79.52±3.54 ** 76.57±1.95 ** 

Values are expressed as Mean ± S.E.M (n=6). One way ANOVA followed by Dunette’s test. *p<0.01, **p<0.001 when compared 

diabetic control group 

Table 4: Effect of ginger, glibenclamide and their combination on serum SOD and CAT in alloxan and streptozotocin induced 

diabetic rats 

Group 
Alloxan STZ 

SOD CAT SOD CAT 

Normal control 12.65±1.18 8.25±1.65 11.36±3.25 6.45±2.57 

Diabetic control 4.56±1.75 4.14±2.65 3.28±1.78 2.35±1.15 

Ginger Extract (500 mg/kg) 6.16±1.34* 4.76±2.12* 5.56±1.76* 3.25±1.43* 

Glibenclamide (5 mg/Kg)  7.55±2.76** 5.92±1.85** 8.46±1.32** 4.05±2.96** 

Glibenclamide (5 mg/Kg) + Ginger extract (500 mg/ Kg) 8.21±2.65** 6.85±1.25** 9.52±2.54** 4.46±2.75** 

Values are expressed as Mean ± SEM (n=6). One way ANOVA followed by Dunette’s test. *p<0.01, **p<0.001 when compared 

diabetic control group 

 

DISCUSSION 

The present study was undertaken to evaluate the antidiabetic 

activity of a standard synthetic antidiabetic drug 

glibenclamide in combination with an herbal bioenhancer drug 

ginger in diabetic rats. Diabetes is a global disease with a huge 

adverse impact on health and mortality, particularly from 

cardiovascular disorders. It occurs at any time of life from 

infancy to old age. Type-2 diabetes is primarily a lifestyle 

disorder, which accounts for around 90% of diabetes cases and 

increasing at an astonishing rate, particularly in developing 

countries like India [7]. 

Diabetes Mellitus is a group of disorders characterized by 

increased blood sugar, polyhydria, polyuria and weight loss. It 

is treated either by allopathic or with traditional system of 

medicines which utilizes herbs for cure. Two national surveys 

examined the prevalence and pattern of use of complementary 

and alternative medicine (CAM) among individuals with 

diabetes. One study by medical expenditure panel survey data 

in 2016 reported that individuals with diabetes were 1.6 times 

more likely to use CAM than persons without diabetes. Data 

from a national representative survey conducted from 2017 to 

2022 reported that 35% of respondents with diabetes used 

CAM to treat their condition [8]. 

Herbs are often administered in combination with 

therapeutic drugs, raising the potential of herb–drug 

interactions. There is very little information published on 

herb–drug interactions while the use of herbs is progressively 

growing across the world. Certain herbal supplements can 

cause potentially dangerous side effects when taken with 

prescription drugs and the number of cases reported for the 

emerging herb–drug interactions are already on the rise [9]. In 

the present study, diabetes was induced using alloxan and 

streptozotocin (STZ). Alloxan is a cyclic urea derivative, is 

reported as a potent diabetogenic agent and has widely been 

used for the induction of experimental diabetes in animal 

species by damaging the insulin secreting pancreatic β-cells, 

resulting in a decrease in endogenous insulin release. Alloxan 



Shenoy M & Mahurkar                       Complementary action of ginger as bioenhancers in the treatment of diabetes 

Vol 3 | Issue 1 | Jan – Mar 2024                                                                         Indian Journal Pharm Drug Studies | 33  

produces oxygen radicals which causes pancreatic injury and 

could be responsible for increased blood glucose seen in the 

animals [10]. Over production (excessive hepatic 

glycogenolysis and gluconeogenesis) and decrease utilization 

of glucose by the tissues are the fundamental basis of 

hyperglycemia in diabetes mellitus. Streptozotocin is a broad 

spectrum antibiotic, induces diabetes in a wide variety of 

animal species by damaging the insulin-secreting cells of the 

pancreas [11]. 

Streptozotocin (STZ) induced diabetes is a valuable model 

for induction of diabetes mellitus. Diabetes mellitus induced 

by STZ may be due to pancreatic β-cells destruction resulting 

in a decrease in endogenous insulin release. IDDM can be 

induced by injecting STZ to adult rats whereas NIDDM is 

induced by administration of STZ to neonatal rats [12]. In this 

study the animals survived without insulin treatment and 

showed improvement by glibenclamide which act by 

stimulating residual beta cells of the pancreas indicate 

incomplete destruction of pancreatic beta cells of the diabetic 

rats in the present study. The model can therefore be 

considered as type II diabetic model showing symptoms like 

hyperglycemia, glycosuria, polyuria, loss of body weight in 

spite of polyphagia [13]. 

Non Insulin Dependent Diabetes Mellitus (NIDDM) also 

called as type 2 diabetes is a complex metabolic disorder that 

involves abnormalities in both insulin secretion and action at 

peripheral tissues. It is a more prevalent form of diabetes and 

responsible for 90% of the disease. In NIDDM, the kinetics of 

insulin release in response to meal or glucose is altered. So, 

postprandial blood glucose remains high and leads to glucose 

intolerance. Postprandial hyperglycemia plays an important 

role in the development of diabetic complications. Poor 

glycogen content in insulin dependent tissues such as liver, 

skeletal muscle and adipose tissues were observed in NIDDM 

due to insulin resistance. In NIDDM, partial or total 

deficiency of insulin causes derangement in carbohydrate 

metabolism [14]. 

Most employed oral hypoglycemic agents are 

sulfonylureas and biguanides. These drugs, however, have 

disadvantages such as primary and secondary failure of 

efficacy as well as the potential for induction of severe 

hypoglycemia. There is a need, therefore, for new candidate 

molecules that may effectively reduce insulin resistance or 

potentiate insulin action in genetically diabetic or obese 

individuals. New drugs that reverse insulin resistance without 

stimulating insulin release from β -cells also fulfill a major 

medical need in the treatment of non-insulin-dependent 

diabetes mellitus (NIDDM). The search for such drugs with a 

potential to reduce long-term complications of NIDDM is, 

therefore, of current interest [15]. 

Glibenclamide is a second generation sulphonylurea 

derivative, oral hypoglycemic agent and found to be effective 

in diabetic rats that retain functioning of islet β-cells. Hence 

the principle mechanism of action is to stimulate the 

production and secretion of insulin by the β-cells of pancreas. 

This drug may lower down the output of glucose from the 

liver by insulin independent mechanism [16]. 

Ginger is the rhizome of the plant Zingiber officinale 

which is a proven herbal bioenhancer. Aqueous extract of 

ginger of concentration 500mg/ml was prepared and used for 

the study. In the present study, the blood lipid levels in both 

alloxan and STZ treated rats were significantly increased as 

compared to normal rats. Whereas the group treated with 

standard drug glibenclamide and those treated with 

glibenclamide + ginger extract combination showed 

significant reduction in lipid profile. The results indicate that 

the combination of glibenclamide and ginger extract could 

lead to increase in the effect of glibenclamide that may be 

helpful to reduce the dose of glibenclamide.  Also, to 

minimize the adverse effects. Insulin deficiency leads to 

various metabolic aberrations in the rats; the rise in LDL level 

is accompanied by increase in SGPT and SGOT level. In this 

present study, glibenclamide and glibenclamide + ginger 

extract combination treated animals serum showed significant 

reduction in SGPT and SGOT level [17]. 

Oxidative stress plays a major role in the pathogenesis of 

both types of diabetes mellitus. Free radicals are formed in 

diabetes by glucose oxidation, protein glycation and the 

subsequent degradation of glycated proteins. High levels of 

free radicals and the simultaneously declined antioxidant 

enzyme levels lead to cell damage, inactivation of enzymes 

and lipid peroxidation. Superoxide dismutase and catalase 

play an important role in the detoxification of super oxide 

anion and H2O2 respectively. In present study, Catalase and 

SOD which are most important antioxidant enzymes were 

found to be decreased in diabetic control group. Treatment 

with glibenclamide and glibenclamide + ginger extract 

combination restores the level of both enzymes [18]. 

CONCLUSIONS 

Intraperitoneal administration of alloxan and streptozotocin 

produced elevated levels of lipid triglycerides, LDL-

cholesterol, hyperglycemia, loss of body weight, increase in 

serum biomarkers such as SGPT and SGOT (liver damage), 

increased oxidative stress due to decrease in antioxidants such 

as SOD and CAT. The animal groups treated with 

glibenclamide and glibenclamide in combination with ginger 

extract showed antidiabetic effect by restoring the above 

markers. The antidiabetic effects are better in animals treated 

with combination of glibenclamide and ginger extract in 

comparison to glibenclamide alone. The findings of the study 

suggest that, ginger shows complementary action with 

glibenclamide in the treatment of diabetes. So it can be 

considered as a safe supplementary in management of diabetes 



Shenoy M & Mahurkar                       Complementary action of ginger as bioenhancers in the treatment of diabetes 

Vol 3 | Issue 1 | Jan – Mar 2024                                                                         Indian Journal Pharm Drug Studies | 34  

mellitus. Further studies has to conducted, to check whether 

dosage of glibenclamide can be reduced when it is given along 

with ginger.  

Acknowledgements: The authors are grateful to management 

of HKES’ Matoshree Taradevi Rampure Institute of 

Pharmaceutical Sciences, Kalaburagi and Srinivas college of 

Pharmacy, Mangalore for providing necessary facilities to 

carry out the experiments. 

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How to cite this article: Ashoka Shenoy M, Nitin 

Mahurkar. Complementary action of ginger as 

bioenhancers in the treatment of diabetes. Indian J Pharm 

Drug Studies. 2024; 3(1):29-34. 

Funding: None;                Conflicts of Interest: None Stated 

 

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