id	sid	tid	token	lemma	pos
ijpds-2904	1	1	sakshi	sakshi	PROPN
ijpds-2904	1	2	and	and	CCONJ
ijpds-2904	1	3	singh	singh	PROPN
ijpds-2904	1	4	cisplatin	cisplatin	NOUN
ijpds-2904	1	5	induced	induce	VERB
ijpds-2904	1	6	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	1	7	vol	vol	NOUN
ijpds-2904	1	8	1	1	NUM
ijpds-2904	1	9	|	|	NOUN
ijpds-2904	1	10	issue	issue	VERB
ijpds-2904	1	11	1	1	NUM
ijpds-2904	1	12	|	|	ADV
ijpds-2904	1	13	apr	apr	ADV
ijpds-2904	1	14	–	–	PUNCT
ijpds-2904	1	15	jun	jun	PROPN
ijpds-2904	1	16	2022	2022	NUM
ijpds-2904	1	17	indian	indian	PROPN
ijpds-2904	1	18	j	j	PROPN
ijpds-2904	1	19	pharm	pharm	PROPN
ijpds-2904	1	20	drug	drug	PROPN
ijpds-2904	1	21	studies	study	NOUN
ijpds-2904	1	22	|	|	ADV
ijpds-2904	1	23	5	5	NUM
ijpds-2904	1	24	review	review	NOUN
ijpds-2904	1	25	article	article	NOUN
ijpds-2904	1	26	role	role	NOUN
ijpds-2904	1	27	of	of	ADP
ijpds-2904	1	28	membrane	membrane	NOUN
ijpds-2904	1	29	transporters	transporter	NOUN
ijpds-2904	1	30	in	in	ADP
ijpds-2904	1	31	cisplatin	cisplatin	NOUN
ijpds-2904	1	32	induced	induce	VERB
ijpds-2904	1	33	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	1	34	sakshi1	sakshi1	PROPN
ijpds-2904	1	35	,	,	PUNCT
ijpds-2904	1	36	gaaminepreet	gaaminepreet	PROPN
ijpds-2904	1	37	singh1	singh1	PROPN
ijpds-2904	1	38	from	from	ADP
ijpds-2904	1	39	,	,	PUNCT
ijpds-2904	1	40	1department	1department	NUM
ijpds-2904	1	41	of	of	ADP
ijpds-2904	1	42	pharmacology	pharmacology	NOUN
ijpds-2904	1	43	,	,	PUNCT
ijpds-2904	1	44	isf	isf	PROPN
ijpds-2904	1	45	college	college	PROPN
ijpds-2904	1	46	of	of	ADP
ijpds-2904	1	47	pharmacy	pharmacy	NOUN
ijpds-2904	1	48	,	,	PUNCT
ijpds-2904	1	49	moga	moga	PROPN
ijpds-2904	1	50	,	,	PUNCT
ijpds-2904	1	51	punjab	punjab	PROPN
ijpds-2904	1	52	.	.	PUNCT
ijpds-2904	2	1	correspondence	correspondence	NOUN
ijpds-2904	2	2	to	to	ADP
ijpds-2904	2	3	:	:	PUNCT
ijpds-2904	2	4	gaaminepreet	gaaminepreet	PROPN
ijpds-2904	2	5	singh	singh	PROPN
ijpds-2904	2	6	,	,	PUNCT
ijpds-2904	2	7	isf	isf	PROPN
ijpds-2904	2	8	college	college	PROPN
ijpds-2904	2	9	of	of	ADP
ijpds-2904	2	10	pharmacy	pharmacy	NOUN
ijpds-2904	2	11	,	,	PUNCT
ijpds-2904	2	12	moga	moga	PROPN
ijpds-2904	2	13	,	,	PUNCT
ijpds-2904	2	14	punjab	punjab	PROPN
ijpds-2904	2	15	,	,	PUNCT
ijpds-2904	2	16	india	india	PROPN
ijpds-2904	2	17	.	.	PUNCT
ijpds-2904	3	1	tel	tel	PROPN
ijpds-2904	3	2	.	.	PUNCT
ijpds-2904	3	3	:	:	PUNCT
ijpds-2904	4	1	+91	+91	NOUN
ijpds-2904	4	2	7696579358	7696579358	NUM
ijpds-2904	4	3	;	;	PUNCT
ijpds-2904	4	4	email	email	NOUN
ijpds-2904	4	5	:	:	PUNCT
ijpds-2904	5	1	gpsinghcologist@hotmail.com	gpsinghcologist@hotmail.com	X
ijpds-2904	5	2	.	.	PUNCT
ijpds-2904	6	1	abstract	abstract	ADJ
ijpds-2904	6	2	transporters	transporter	NOUN
ijpds-2904	6	3	are	be	AUX
ijpds-2904	6	4	important	important	ADJ
ijpds-2904	6	5	mediators	mediator	NOUN
ijpds-2904	6	6	of	of	ADP
ijpds-2904	6	7	specific	specific	ADJ
ijpds-2904	6	8	cellular	cellular	ADJ
ijpds-2904	6	9	uptake	uptake	NOUN
ijpds-2904	6	10	and	and	CCONJ
ijpds-2904	6	11	thus	thus	ADV
ijpds-2904	6	12	,	,	PUNCT
ijpds-2904	6	13	not	not	PART
ijpds-2904	6	14	only	only	ADV
ijpds-2904	6	15	for	for	ADP
ijpds-2904	6	16	effects	effect	NOUN
ijpds-2904	6	17	,	,	PUNCT
ijpds-2904	6	18	but	but	CCONJ
ijpds-2904	6	19	also	also	ADV
ijpds-2904	6	20	for	for	ADP
ijpds-2904	6	21	side	side	NOUN
ijpds-2904	6	22	effects	effect	NOUN
ijpds-2904	6	23	,	,	PUNCT
ijpds-2904	6	24	metabolism	metabolism	NOUN
ijpds-2904	6	25	,	,	PUNCT
ijpds-2904	6	26	and	and	CCONJ
ijpds-2904	6	27	excretion	excretion	NOUN
ijpds-2904	6	28	of	of	ADP
ijpds-2904	6	29	many	many	ADJ
ijpds-2904	6	30	drugs	drug	NOUN
ijpds-2904	6	31	such	such	ADJ
ijpds-2904	6	32	as	as	ADP
ijpds-2904	6	33	cisplatin	cisplatin	NOUN
ijpds-2904	6	34	.	.	PUNCT
ijpds-2904	7	1	cisplatin	cisplatin	NOUN
ijpds-2904	7	2	is	be	AUX
ijpds-2904	7	3	a	a	DET
ijpds-2904	7	4	potent	potent	ADJ
ijpds-2904	7	5	cytostatic	cytostatic	ADJ
ijpds-2904	7	6	drug	drug	NOUN
ijpds-2904	7	7	,	,	PUNCT
ijpds-2904	7	8	whose	whose	DET
ijpds-2904	7	9	use	use	NOUN
ijpds-2904	7	10	is	be	AUX
ijpds-2904	7	11	limited	limit	VERB
ijpds-2904	7	12	by	by	ADP
ijpds-2904	7	13	its	its	PRON
ijpds-2904	7	14	severe	severe	ADJ
ijpds-2904	7	15	acute	acute	NOUN
ijpds-2904	7	16	and	and	CCONJ
ijpds-2904	7	17	chronic	chronic	ADJ
ijpds-2904	7	18	nephro-	nephro-	NUM
ijpds-2904	7	19	,	,	PUNCT
ijpds-2904	7	20	oto-	oto-	ADV
ijpds-2904	7	21	,	,	PUNCT
ijpds-2904	7	22	and	and	CCONJ
ijpds-2904	7	23	peripheral	peripheral	ADJ
ijpds-2904	7	24	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	7	25	.	.	PUNCT
ijpds-2904	8	1	for	for	ADP
ijpds-2904	8	2	this	this	DET
ijpds-2904	8	3	reason	reason	NOUN
ijpds-2904	8	4	,	,	PUNCT
ijpds-2904	8	5	other	other	ADJ
ijpds-2904	8	6	platinum	platinum	NOUN
ijpds-2904	8	7	derivatives	derivative	NOUN
ijpds-2904	8	8	,	,	PUNCT
ijpds-2904	8	9	such	such	ADJ
ijpds-2904	8	10	as	as	ADP
ijpds-2904	8	11	carboplatin	carboplatin	NOUN
ijpds-2904	8	12	and	and	CCONJ
ijpds-2904	8	13	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	8	14	,	,	PUNCT
ijpds-2904	8	15	with	with	ADP
ijpds-2904	8	16	less	less	ADJ
ijpds-2904	8	17	toxicity	toxicity	NOUN
ijpds-2904	8	18	but	but	CCONJ
ijpds-2904	8	19	still	still	ADV
ijpds-2904	8	20	with	with	ADP
ijpds-2904	8	21	antitumoral	antitumoral	ADJ
ijpds-2904	8	22	action	action	NOUN
ijpds-2904	8	23	have	have	AUX
ijpds-2904	8	24	been	be	AUX
ijpds-2904	8	25	developed	develop	VERB
ijpds-2904	8	26	.	.	PUNCT
ijpds-2904	9	1	several	several	ADJ
ijpds-2904	9	2	transporters	transporter	NOUN
ijpds-2904	9	3	,	,	PUNCT
ijpds-2904	9	4	which	which	PRON
ijpds-2904	9	5	are	be	AUX
ijpds-2904	9	6	expressed	express	VERB
ijpds-2904	9	7	on	on	ADP
ijpds-2904	9	8	the	the	DET
ijpds-2904	9	9	cell	cell	NOUN
ijpds-2904	9	10	membranes	membrane	NOUN
ijpds-2904	9	11	,	,	PUNCT
ijpds-2904	9	12	have	have	AUX
ijpds-2904	9	13	been	be	AUX
ijpds-2904	9	14	associated	associate	VERB
ijpds-2904	9	15	with	with	ADP
ijpds-2904	9	16	cisplatin	cisplatin	NOUN
ijpds-2904	9	17	transport	transport	NOUN
ijpds-2904	9	18	across	across	ADP
ijpds-2904	9	19	the	the	DET
ijpds-2904	9	20	plasma	plasma	NOUN
ijpds-2904	9	21	membrane	membrane	NOUN
ijpds-2904	9	22	and	and	CCONJ
ijpds-2904	9	23	across	across	ADP
ijpds-2904	9	24	the	the	DET
ijpds-2904	9	25	cell	cell	NOUN
ijpds-2904	9	26	:	:	PUNCT
ijpds-2904	9	27	the	the	DET
ijpds-2904	9	28	copper	copper	NOUN
ijpds-2904	9	29	transporter	transporter	NOUN
ijpds-2904	9	30	1	1	NUM
ijpds-2904	9	31	(	(	PUNCT
ijpds-2904	9	32	ctr1	ctr1	PROPN
ijpds-2904	9	33	)	)	PUNCT
ijpds-2904	9	34	,	,	PUNCT
ijpds-2904	9	35	the	the	DET
ijpds-2904	9	36	copper	copper	NOUN
ijpds-2904	9	37	transporter	transporter	NOUN
ijpds-2904	9	38	2	2	NUM
ijpds-2904	9	39	(	(	PUNCT
ijpds-2904	9	40	ctr2	ctr2	PROPN
ijpds-2904	9	41	)	)	PUNCT
ijpds-2904	9	42	,	,	PUNCT
ijpds-2904	9	43	the	the	DET
ijpds-2904	9	44	ptype	ptype	ADJ
ijpds-2904	9	45	copper	copper	NOUN
ijpds-2904	9	46	-	-	PUNCT
ijpds-2904	9	47	transporting	transport	VERB
ijpds-2904	9	48	atpases	atpase	NOUN
ijpds-2904	9	49	atp7a	atp7a	PUNCT
ijpds-2904	9	50	and	and	CCONJ
ijpds-2904	9	51	atp7b	atp7b	PROPN
ijpds-2904	9	52	,	,	PUNCT
ijpds-2904	9	53	the	the	DET
ijpds-2904	9	54	organic	organic	ADJ
ijpds-2904	9	55	cation	cation	NOUN
ijpds-2904	9	56	transporter	transporter	NOUN
ijpds-2904	9	57	2	2	NUM
ijpds-2904	9	58	(	(	PUNCT
ijpds-2904	9	59	oct2	oct2	NOUN
ijpds-2904	9	60	)	)	PUNCT
ijpds-2904	9	61	,	,	PUNCT
ijpds-2904	9	62	and	and	CCONJ
ijpds-2904	9	63	the	the	DET
ijpds-2904	9	64	multidrug	multidrug	NOUN
ijpds-2904	9	65	extrusion	extrusion	NOUN
ijpds-2904	9	66	transporter	transporter	NOUN
ijpds-2904	9	67	1	1	NUM
ijpds-2904	9	68	(	(	PUNCT
ijpds-2904	9	69	mate1	mate1	NOUN
ijpds-2904	9	70	)	)	PUNCT
ijpds-2904	9	71	.	.	PUNCT
ijpds-2904	10	1	some	some	PRON
ijpds-2904	10	2	of	of	ADP
ijpds-2904	10	3	these	these	DET
ijpds-2904	10	4	transporters	transporter	NOUN
ijpds-2904	10	5	are	be	AUX
ijpds-2904	10	6	also	also	ADV
ijpds-2904	10	7	able	able	ADJ
ijpds-2904	10	8	to	to	PART
ijpds-2904	10	9	accept	accept	VERB
ijpds-2904	10	10	other	other	ADJ
ijpds-2904	10	11	platinum	platinum	NOUN
ijpds-2904	10	12	derivatives	derivative	NOUN
ijpds-2904	10	13	as	as	ADP
ijpds-2904	10	14	substrate	substrate	NOUN
ijpds-2904	10	15	.	.	PUNCT
ijpds-2904	11	1	since	since	SCONJ
ijpds-2904	11	2	membrane	membrane	NOUN
ijpds-2904	11	3	transporters	transporter	NOUN
ijpds-2904	11	4	display	display	VERB
ijpds-2904	11	5	a	a	DET
ijpds-2904	11	6	specific	specific	ADJ
ijpds-2904	11	7	tissue	tissue	NOUN
ijpds-2904	11	8	distribution	distribution	NOUN
ijpds-2904	11	9	,	,	PUNCT
ijpds-2904	11	10	they	they	PRON
ijpds-2904	11	11	can	can	AUX
ijpds-2904	11	12	be	be	AUX
ijpds-2904	11	13	important	important	ADJ
ijpds-2904	11	14	molecules	molecule	NOUN
ijpds-2904	11	15	that	that	PRON
ijpds-2904	11	16	mediate	mediate	VERB
ijpds-2904	11	17	the	the	DET
ijpds-2904	11	18	entry	entry	NOUN
ijpds-2904	11	19	of	of	ADP
ijpds-2904	11	20	platinum	platinum	NOUN
ijpds-2904	11	21	derivatives	derivative	NOUN
ijpds-2904	11	22	in	in	ADP
ijpds-2904	11	23	target	target	NOUN
ijpds-2904	11	24	and	and	CCONJ
ijpds-2904	11	25	also	also	ADV
ijpds-2904	11	26	non	non	ADJ
ijpds-2904	11	27	-	-	ADJ
ijpds-2904	11	28	target	target	ADJ
ijpds-2904	11	29	cells	cell	NOUN
ijpds-2904	11	30	possibly	possibly	ADV
ijpds-2904	11	31	mediating	mediate	VERB
ijpds-2904	11	32	specific	specific	ADJ
ijpds-2904	11	33	effects	effect	NOUN
ijpds-2904	11	34	and	and	CCONJ
ijpds-2904	11	35	side	side	NOUN
ijpds-2904	11	36	effects	effect	NOUN
ijpds-2904	11	37	of	of	ADP
ijpds-2904	11	38	the	the	DET
ijpds-2904	11	39	chemotherapeutic	chemotherapeutic	ADJ
ijpds-2904	11	40	drug	drug	NOUN
ijpds-2904	11	41	.	.	PUNCT
ijpds-2904	12	1	this	this	DET
ijpds-2904	12	2	paper	paper	NOUN
ijpds-2904	12	3	summarizes	summarize	VERB
ijpds-2904	12	4	the	the	DET
ijpds-2904	12	5	literature	literature	NOUN
ijpds-2904	12	6	on	on	ADP
ijpds-2904	12	7	toxicities	toxicity	NOUN
ijpds-2904	12	8	of	of	ADP
ijpds-2904	12	9	cisplatin	cisplatin	NOUN
ijpds-2904	12	10	compared	compare	VERB
ijpds-2904	12	11	to	to	ADP
ijpds-2904	12	12	that	that	PRON
ijpds-2904	12	13	of	of	ADP
ijpds-2904	12	14	carboplatin	carboplatin	NOUN
ijpds-2904	12	15	and	and	CCONJ
ijpds-2904	12	16	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	12	17	and	and	CCONJ
ijpds-2904	12	18	the	the	DET
ijpds-2904	12	19	interaction	interaction	NOUN
ijpds-2904	12	20	of	of	ADP
ijpds-2904	12	21	these	these	DET
ijpds-2904	12	22	platinum	platinum	NOUN
ijpds-2904	12	23	derivatives	derivative	NOUN
ijpds-2904	12	24	with	with	ADP
ijpds-2904	12	25	membrane	membrane	NOUN
ijpds-2904	12	26	transporters	transporter	NOUN
ijpds-2904	12	27	.	.	PUNCT
ijpds-2904	13	1	keywords	keyword	NOUN
ijpds-2904	13	2	:	:	PUNCT
ijpds-2904	13	3	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	13	4	,	,	PUNCT
ijpds-2904	13	5	ototoxicity	ototoxicity	NOUN
ijpds-2904	13	6	,	,	PUNCT
ijpds-2904	13	7	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	13	8	,	,	PUNCT
ijpds-2904	13	9	mate1	mate1	NOUN
ijpds-2904	13	10	,	,	PUNCT
ijpds-2904	13	11	oct2	oct2	NOUN
ijpds-2904	13	12	,	,	PUNCT
ijpds-2904	13	13	ctr2	ctr2	PROPN
ijpds-2904	13	14	.	.	PUNCT
ijpds-2904	14	1	n	n	CCONJ
ijpds-2904	14	2	the	the	DET
ijpds-2904	14	3	last	last	ADJ
ijpds-2904	14	4	several	several	ADJ
ijpds-2904	14	5	decades	decade	NOUN
ijpds-2904	14	6	,	,	PUNCT
ijpds-2904	14	7	novel	novel	ADJ
ijpds-2904	14	8	cancer	cancer	NOUN
ijpds-2904	14	9	drugs	drug	NOUN
ijpds-2904	14	10	have	have	AUX
ijpds-2904	14	11	been	be	AUX
ijpds-2904	14	12	developed	develop	VERB
ijpds-2904	14	13	and	and	CCONJ
ijpds-2904	14	14	used	use	VERB
ijpds-2904	14	15	in	in	ADP
ijpds-2904	14	16	clinical	clinical	ADJ
ijpds-2904	14	17	practice	practice	NOUN
ijpds-2904	14	18	,	,	PUNCT
ijpds-2904	14	19	being	be	AUX
ijpds-2904	14	20	more	more	ADV
ijpds-2904	14	21	specific	specific	ADJ
ijpds-2904	14	22	against	against	ADP
ijpds-2904	14	23	cancer	cancer	NOUN
ijpds-2904	14	24	cells	cell	NOUN
ijpds-2904	14	25	and	and	CCONJ
ijpds-2904	14	26	extremely	extremely	ADV
ijpds-2904	14	27	effective	effective	ADJ
ijpds-2904	14	28	against	against	ADP
ijpds-2904	14	29	several	several	ADJ
ijpds-2904	14	30	previously	previously	ADV
ijpds-2904	14	31	untreatable	untreatable	ADJ
ijpds-2904	14	32	malignancies	malignancy	NOUN
ijpds-2904	14	33	,	,	PUNCT
ijpds-2904	14	34	the	the	DET
ijpds-2904	14	35	so	so	ADV
ijpds-2904	14	36	-	-	PUNCT
ijpds-2904	14	37	called	call	VERB
ijpds-2904	14	38	molecularly	molecularly	ADV
ijpds-2904	14	39	targeted	target	VERB
ijpds-2904	14	40	agents	agent	NOUN
ijpds-2904	14	41	,	,	PUNCT
ijpds-2904	14	42	but	but	CCONJ
ijpds-2904	14	43	also	also	ADV
ijpds-2904	14	44	suffer	suffer	VERB
ijpds-2904	14	45	from	from	ADP
ijpds-2904	14	46	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	14	47	which	which	PRON
ijpds-2904	14	48	limits	limit	VERB
ijpds-2904	14	49	the	the	DET
ijpds-2904	14	50	efficacy	efficacy	NOUN
ijpds-2904	14	51	of	of	ADP
ijpds-2904	14	52	the	the	DET
ijpds-2904	14	53	treatment	treatment	NOUN
ijpds-2904	14	54	and	and	CCONJ
ijpds-2904	14	55	impact	impact	VERB
ijpds-2904	14	56	their	their	PRON
ijpds-2904	14	57	quality	quality	NOUN
ijpds-2904	14	58	of	of	ADP
ijpds-2904	14	59	life	life	NOUN
ijpds-2904	14	60	and	and	CCONJ
ijpds-2904	14	61	overall	overall	ADJ
ijpds-2904	14	62	survival	survival	NOUN
ijpds-2904	15	1	[	[	X
ijpds-2904	15	2	1	1	NUM
ijpds-2904	15	3	]	]	PUNCT
ijpds-2904	15	4	.	.	PUNCT
ijpds-2904	16	1	most	most	ADJ
ijpds-2904	16	2	of	of	ADP
ijpds-2904	16	3	the	the	DET
ijpds-2904	16	4	chemotherapeutic	chemotherapeutic	ADJ
ijpds-2904	16	5	agents	agent	NOUN
ijpds-2904	16	6	developed	develop	VERB
ijpds-2904	16	7	so	so	ADV
ijpds-2904	16	8	far	far	ADV
ijpds-2904	16	9	exert	exert	VERB
ijpds-2904	16	10	their	their	PRON
ijpds-2904	16	11	action	action	NOUN
ijpds-2904	16	12	in	in	ADP
ijpds-2904	16	13	the	the	DET
ijpds-2904	16	14	cell	cell	NOUN
ijpds-2904	16	15	and	and	CCONJ
ijpds-2904	16	16	therefore	therefore	ADV
ijpds-2904	16	17	have	have	VERB
ijpds-2904	16	18	to	to	PART
ijpds-2904	16	19	cross	cross	VERB
ijpds-2904	16	20	the	the	DET
ijpds-2904	16	21	cell	cell	NOUN
ijpds-2904	16	22	membrane	membrane	NOUN
ijpds-2904	16	23	to	to	PART
ijpds-2904	16	24	reach	reach	VERB
ijpds-2904	16	25	their	their	PRON
ijpds-2904	16	26	targets	target	NOUN
ijpds-2904	16	27	[	[	X
ijpds-2904	16	28	2	2	NUM
ijpds-2904	16	29	]	]	PUNCT
ijpds-2904	16	30	.	.	PUNCT
ijpds-2904	17	1	however	however	ADV
ijpds-2904	17	2	,	,	PUNCT
ijpds-2904	17	3	they	they	PRON
ijpds-2904	17	4	are	be	AUX
ijpds-2904	17	5	often	often	ADV
ijpds-2904	17	6	poorly	poorly	ADV
ijpds-2904	17	7	lipophilic	lipophilic	ADJ
ijpds-2904	17	8	compounds	compound	NOUN
ijpds-2904	17	9	,	,	PUNCT
ijpds-2904	17	10	which	which	PRON
ijpds-2904	17	11	can	can	AUX
ijpds-2904	17	12	not	not	PART
ijpds-2904	17	13	easily	easily	ADV
ijpds-2904	17	14	pass	pass	VERB
ijpds-2904	17	15	the	the	DET
ijpds-2904	17	16	cell	cell	NOUN
ijpds-2904	17	17	membrane	membrane	NOUN
ijpds-2904	17	18	and	and	CCONJ
ijpds-2904	17	19	thus	thus	ADV
ijpds-2904	17	20	need	need	VERB
ijpds-2904	17	21	to	to	PART
ijpds-2904	17	22	be	be	AUX
ijpds-2904	17	23	transported	transport	VERB
ijpds-2904	17	24	into	into	ADP
ijpds-2904	17	25	the	the	DET
ijpds-2904	17	26	cell	cell	NOUN
ijpds-2904	17	27	by	by	ADP
ijpds-2904	17	28	specific	specific	ADJ
ijpds-2904	17	29	systems	system	NOUN
ijpds-2904	17	30	of	of	ADP
ijpds-2904	17	31	protein	protein	NOUN
ijpds-2904	17	32	nature	nature	NOUN
ijpds-2904	17	33	called	call	VERB
ijpds-2904	17	34	transporters	transporter	NOUN
ijpds-2904	17	35	[	[	X
ijpds-2904	17	36	3	3	NUM
ijpds-2904	17	37	]	]	PUNCT
ijpds-2904	17	38	.	.	PUNCT
ijpds-2904	18	1	general	general	ADJ
ijpds-2904	18	2	concept	concept	NOUN
ijpds-2904	18	3	of	of	ADP
ijpds-2904	18	4	drug	drug	NOUN
ijpds-2904	18	5	movement	movement	NOUN
ijpds-2904	18	6	across	across	ADP
ijpds-2904	18	7	biological	biological	ADJ
ijpds-2904	18	8	membranes	membrane	NOUN
ijpds-2904	18	9	is	be	AUX
ijpds-2904	18	10	that	that	SCONJ
ijpds-2904	18	11	they	they	PRON
ijpds-2904	18	12	can	can	AUX
ijpds-2904	18	13	pass	pass	VERB
ijpds-2904	18	14	cell	cell	NOUN
ijpds-2904	18	15	membranes	membrane	NOUN
ijpds-2904	18	16	via	via	ADP
ijpds-2904	18	17	passive	passive	ADJ
ijpds-2904	18	18	diffusion	diffusion	NOUN
ijpds-2904	18	19	at	at	ADP
ijpds-2904	18	20	a	a	DET
ijpds-2904	18	21	rate	rate	NOUN
ijpds-2904	18	22	related	relate	VERB
ijpds-2904	18	23	to	to	ADP
ijpds-2904	18	24	their	their	PRON
ijpds-2904	18	25	lipophilicity	lipophilicity	NOUN
ijpds-2904	18	26	.	.	PUNCT
ijpds-2904	19	1	however	however	ADV
ijpds-2904	19	2	,	,	PUNCT
ijpds-2904	19	3	it	it	PRON
ijpds-2904	19	4	is	be	AUX
ijpds-2904	19	5	becoming	become	VERB
ijpds-2904	19	6	evident	evident	ADJ
ijpds-2904	19	7	that	that	SCONJ
ijpds-2904	19	8	membrane	membrane	NOUN
ijpds-2904	19	9	transporters	transporter	NOUN
ijpds-2904	19	10	are	be	AUX
ijpds-2904	19	11	also	also	ADV
ijpds-2904	19	12	important	important	ADJ
ijpds-2904	19	13	determinants	determinant	NOUN
ijpds-2904	19	14	of	of	ADP
ijpds-2904	19	15	in	in	ADP
ijpds-2904	19	16	vivo	vivo	ADJ
ijpds-2904	19	17	drug	drug	NOUN
ijpds-2904	19	18	disposition	disposition	NOUN
ijpds-2904	19	19	,	,	PUNCT
ijpds-2904	19	20	therapeutic	therapeutic	ADJ
ijpds-2904	19	21	efficacy	efficacy	NOUN
ijpds-2904	19	22	,	,	PUNCT
ijpds-2904	19	23	and	and	CCONJ
ijpds-2904	19	24	adverse	adverse	ADJ
ijpds-2904	19	25	drug	drug	NOUN
ijpds-2904	19	26	reactions	reaction	NOUN
ijpds-2904	19	27	[	[	X
ijpds-2904	19	28	3	3	NUM
ijpds-2904	19	29	]	]	PUNCT
ijpds-2904	19	30	.	.	PUNCT
ijpds-2904	20	1	in	in	ADP
ijpds-2904	20	2	epithelial	epithelial	ADJ
ijpds-2904	20	3	tissues	tissue	NOUN
ijpds-2904	20	4	,	,	PUNCT
ijpds-2904	20	5	which	which	PRON
ijpds-2904	20	6	are	be	AUX
ijpds-2904	20	7	constituted	constitute	VERB
ijpds-2904	20	8	by	by	ADP
ijpds-2904	20	9	polarized	polarize	VERB
ijpds-2904	20	10	cells	cell	NOUN
ijpds-2904	20	11	,	,	PUNCT
ijpds-2904	20	12	transporters	transporter	NOUN
ijpds-2904	20	13	are	be	AUX
ijpds-2904	20	14	even	even	ADV
ijpds-2904	20	15	specifically	specifically	ADV
ijpds-2904	20	16	expressed	express	VERB
ijpds-2904	20	17	on	on	ADP
ijpds-2904	20	18	the	the	DET
ijpds-2904	20	19	apical	apical	ADJ
ijpds-2904	20	20	or	or	CCONJ
ijpds-2904	20	21	baso	baso	NOUN
ijpds-2904	20	22	-	-	PUNCT
ijpds-2904	20	23	lateral	lateral	ADJ
ijpds-2904	20	24	cell	cell	NOUN
ijpds-2904	20	25	membrane	membrane	NOUN
ijpds-2904	20	26	[	[	X
ijpds-2904	20	27	4	4	NUM
ijpds-2904	20	28	]	]	PUNCT
ijpds-2904	20	29	.	.	PUNCT
ijpds-2904	21	1	in	in	ADP
ijpds-2904	21	2	this	this	DET
ijpds-2904	21	3	way	way	NOUN
ijpds-2904	21	4	,	,	PUNCT
ijpds-2904	21	5	a	a	DET
ijpds-2904	21	6	specific	specific	ADJ
ijpds-2904	21	7	drugtransporter	drugtransporter	NOUN
ijpds-2904	21	8	interaction	interaction	NOUN
ijpds-2904	21	9	can	can	AUX
ijpds-2904	21	10	be	be	AUX
ijpds-2904	21	11	exploited	exploit	VERB
ijpds-2904	21	12	to	to	PART
ijpds-2904	21	13	target	target	VERB
ijpds-2904	21	14	drugs	drug	NOUN
ijpds-2904	21	15	to	to	ADP
ijpds-2904	21	16	selected	select	VERB
ijpds-2904	21	17	cells	cell	NOUN
ijpds-2904	21	18	and	and	CCONJ
ijpds-2904	21	19	tissues	tissue	NOUN
ijpds-2904	21	20	,	,	PUNCT
ijpds-2904	21	21	but	but	CCONJ
ijpds-2904	21	22	of	of	ADP
ijpds-2904	21	23	course	course	NOUN
ijpds-2904	21	24	can	can	AUX
ijpds-2904	21	25	also	also	ADV
ijpds-2904	21	26	explain	explain	VERB
ijpds-2904	21	27	specific	specific	ADJ
ijpds-2904	21	28	undesired	undesired	ADJ
ijpds-2904	21	29	adverse	adverse	ADJ
ijpds-2904	21	30	effects	effect	NOUN
ijpds-2904	21	31	[	[	X
ijpds-2904	21	32	5	5	NUM
ijpds-2904	21	33	]	]	PUNCT
ijpds-2904	21	34	.	.	PUNCT
ijpds-2904	22	1	membrane	membrane	NOUN
ijpds-2904	22	2	transporters	transporter	NOUN
ijpds-2904	22	3	such	such	ADJ
ijpds-2904	22	4	as	as	ADP
ijpds-2904	22	5	the	the	DET
ijpds-2904	22	6	copper	copper	NOUN
ijpds-2904	22	7	transporter-1	transporter-1	PROPN
ijpds-2904	22	8	(	(	PUNCT
ijpds-2904	22	9	ctr1	ctr1	PROPN
ijpds-2904	22	10	)	)	PUNCT
ijpds-2904	22	11	,	,	PUNCT
ijpds-2904	22	12	the	the	DET
ijpds-2904	22	13	copper	copper	NOUN
ijpds-2904	22	14	transporter-2	transporter-2	NUM
ijpds-2904	22	15	(	(	PUNCT
ijpds-2904	22	16	ctr2	ctr2	PROPN
ijpds-2904	22	17	)	)	PUNCT
ijpds-2904	22	18	,	,	PUNCT
ijpds-2904	22	19	the	the	DET
ijpds-2904	22	20	p	p	ADJ
ijpds-2904	22	21	-	-	PUNCT
ijpds-2904	22	22	type	type	NOUN
ijpds-2904	22	23	copper	copper	NOUN
ijpds-2904	22	24	transporting	transporting	NOUN
ijpds-2904	22	25	atpases	atpase	NOUN
ijpds-2904	22	26	atp7a	atp7a	PROPN
ijpds-2904	22	27	and	and	CCONJ
ijpds-2904	22	28	atp7b	atp7b	PROPN
ijpds-2904	22	29	,	,	PUNCT
ijpds-2904	22	30	the	the	DET
ijpds-2904	22	31	organic	organic	ADJ
ijpds-2904	22	32	cation	cation	NOUN
ijpds-2904	22	33	transporter-2	transporter-2	NUM
ijpds-2904	22	34	(	(	PUNCT
ijpds-2904	22	35	oct2	oct2	PROPN
ijpds-2904	22	36	)	)	PUNCT
ijpds-2904	22	37	,	,	PUNCT
ijpds-2904	22	38	and	and	CCONJ
ijpds-2904	22	39	the	the	DET
ijpds-2904	22	40	multidrug	multidrug	NOUN
ijpds-2904	22	41	extrusion	extrusion	NOUN
ijpds-2904	22	42	transporter-1	transporter-1	NUM
ijpds-2904	22	43	(	(	PUNCT
ijpds-2904	22	44	mate1	mate1	NOUN
ijpds-2904	22	45	)	)	PUNCT
ijpds-2904	22	46	mediate	mediate	VERB
ijpds-2904	22	47	cellular	cellular	ADJ
ijpds-2904	22	48	transport	transport	NOUN
ijpds-2904	22	49	of	of	ADP
ijpds-2904	22	50	cisplatin	cisplatin	NOUN
ijpds-2904	22	51	[	[	X
ijpds-2904	22	52	6	6	NUM
ijpds-2904	22	53	]	]	PUNCT
ijpds-2904	22	54	.	.	PUNCT
ijpds-2904	23	1	transporter	transporter	NOUN
ijpds-2904	23	2	mediated	mediate	VERB
ijpds-2904	23	3	uptake	uptake	NOUN
ijpds-2904	23	4	has	have	AUX
ijpds-2904	23	5	been	be	AUX
ijpds-2904	23	6	shown	show	VERB
ijpds-2904	23	7	to	to	PART
ijpds-2904	23	8	be	be	AUX
ijpds-2904	23	9	an	an	DET
ijpds-2904	23	10	important	important	ADJ
ijpds-2904	23	11	process	process	NOUN
ijpds-2904	23	12	mediating	mediate	VERB
ijpds-2904	23	13	cellular	cellular	ADJ
ijpds-2904	23	14	accumulation	accumulation	NOUN
ijpds-2904	23	15	of	of	ADP
ijpds-2904	23	16	cisplatin	cisplatin	NOUN
ijpds-2904	23	17	.	.	PUNCT
ijpds-2904	24	1	cisplatin	cisplatin	NOUN
ijpds-2904	24	2	is	be	AUX
ijpds-2904	24	3	one	one	NUM
ijpds-2904	24	4	of	of	ADP
ijpds-2904	24	5	the	the	DET
ijpds-2904	24	6	most	most	ADV
ijpds-2904	24	7	widely	widely	ADV
ijpds-2904	24	8	utilized	utilize	VERB
ijpds-2904	24	9	antitumor	antitumor	NOUN
ijpds-2904	24	10	drugs	drug	NOUN
ijpds-2904	24	11	in	in	ADP
ijpds-2904	24	12	the	the	DET
ijpds-2904	24	13	world	world	NOUN
ijpds-2904	25	1	[	[	X
ijpds-2904	25	2	7	7	NUM
ijpds-2904	25	3	]	]	PUNCT
ijpds-2904	25	4	.	.	PUNCT
ijpds-2904	26	1	cisplatin	cisplatin	PROPN
ijpds-2904	26	2	was	be	AUX
ijpds-2904	26	3	the	the	DET
ijpds-2904	26	4	first	first	ADJ
ijpds-2904	26	5	platinum	platinum	NOUN
ijpds-2904	26	6	-	-	PUNCT
ijpds-2904	26	7	based	base	VERB
ijpds-2904	26	8	drug	drug	NOUN
ijpds-2904	26	9	that	that	PRON
ijpds-2904	26	10	revolutionized	revolutionize	VERB
ijpds-2904	26	11	the	the	DET
ijpds-2904	26	12	treatment	treatment	NOUN
ijpds-2904	26	13	of	of	ADP
ijpds-2904	26	14	neoplastic	neoplastic	ADJ
ijpds-2904	26	15	diseases	disease	NOUN
ijpds-2904	26	16	.	.	PUNCT
ijpds-2904	27	1	for	for	ADP
ijpds-2904	27	2	example	example	NOUN
ijpds-2904	27	3	,	,	PUNCT
ijpds-2904	27	4	before	before	ADP
ijpds-2904	27	5	the	the	DET
ijpds-2904	27	6	introduction	introduction	NOUN
ijpds-2904	27	7	of	of	ADP
ijpds-2904	27	8	cisplatin	cisplatin	NOUN
ijpds-2904	27	9	as	as	ADP
ijpds-2904	27	10	chemotherapeutic	chemotherapeutic	ADJ
ijpds-2904	27	11	agent	agent	NOUN
ijpds-2904	27	12	,	,	PUNCT
ijpds-2904	27	13	testicular	testicular	ADJ
ijpds-2904	27	14	cancer	cancer	NOUN
ijpds-2904	27	15	was	be	AUX
ijpds-2904	27	16	associated	associate	VERB
ijpds-2904	27	17	with	with	ADP
ijpds-2904	27	18	a	a	DET
ijpds-2904	27	19	survival	survival	NOUN
ijpds-2904	27	20	rate	rate	NOUN
ijpds-2904	27	21	of	of	ADP
ijpds-2904	27	22	only	only	ADV
ijpds-2904	27	23	5	5	NUM
ijpds-2904	27	24	%	%	NOUN
ijpds-2904	27	25	[	[	X
ijpds-2904	27	26	8	8	NUM
ijpds-2904	27	27	]	]	PUNCT
ijpds-2904	27	28	.	.	PUNCT
ijpds-2904	28	1	today	today	NOUN
ijpds-2904	28	2	,	,	PUNCT
ijpds-2904	28	3	treatment	treatment	NOUN
ijpds-2904	28	4	of	of	ADP
ijpds-2904	28	5	this	this	DET
ijpds-2904	28	6	cancer	cancer	NOUN
ijpds-2904	28	7	with	with	ADP
ijpds-2904	28	8	a	a	DET
ijpds-2904	28	9	combination	combination	NOUN
ijpds-2904	28	10	of	of	ADP
ijpds-2904	28	11	new	new	ADJ
ijpds-2904	28	12	surgical	surgical	ADJ
ijpds-2904	28	13	techniques	technique	NOUN
ijpds-2904	28	14	and	and	CCONJ
ijpds-2904	28	15	cisplatin	cisplatin	NOUN
ijpds-2904	28	16	chemotherapy	chemotherapy	NOUN
ijpds-2904	28	17	allows	allow	VERB
ijpds-2904	28	18	to	to	PART
ijpds-2904	28	19	achieve	achieve	VERB
ijpds-2904	28	20	a	a	DET
ijpds-2904	28	21	cure	cure	NOUN
ijpds-2904	28	22	rate	rate	NOUN
ijpds-2904	28	23	of	of	ADP
ijpds-2904	28	24	over	over	ADP
ijpds-2904	28	25	90	90	NUM
ijpds-2904	28	26	%	%	NOUN
ijpds-2904	28	27	.	.	PUNCT
ijpds-2904	29	1	currently	currently	ADV
ijpds-2904	29	2	,	,	PUNCT
ijpds-2904	29	3	cisplatin	cisplatin	NOUN
ijpds-2904	29	4	is	be	AUX
ijpds-2904	29	5	widely	widely	ADV
ijpds-2904	29	6	used	use	VERB
ijpds-2904	29	7	for	for	ADP
ijpds-2904	29	8	the	the	DET
ijpds-2904	29	9	therapy	therapy	NOUN
ijpds-2904	29	10	of	of	ADP
ijpds-2904	29	11	solid	solid	ADJ
ijpds-2904	29	12	tumors	tumor	NOUN
ijpds-2904	30	1	[	[	X
ijpds-2904	30	2	9	9	NUM
ijpds-2904	30	3	]	]	PUNCT
ijpds-2904	30	4	.	.	PUNCT
ijpds-2904	31	1	however	however	ADV
ijpds-2904	31	2	,	,	PUNCT
ijpds-2904	31	3	its	its	PRON
ijpds-2904	31	4	use	use	NOUN
ijpds-2904	31	5	is	be	AUX
ijpds-2904	31	6	limited	limit	VERB
ijpds-2904	31	7	by	by	ADP
ijpds-2904	31	8	severe	severe	ADJ
ijpds-2904	31	9	side	side	NOUN
ijpds-2904	31	10	effects	effect	NOUN
ijpds-2904	31	11	such	such	ADJ
ijpds-2904	31	12	as	as	ADP
ijpds-2904	31	13	nephroand	nephroand	NOUN
ijpds-2904	31	14	ototoxicity	ototoxicity	NOUN
ijpds-2904	31	15	and	and	CCONJ
ijpds-2904	31	16	peripheral	peripheral	ADJ
ijpds-2904	31	17	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	31	18	.	.	PUNCT
ijpds-2904	32	1	therefore	therefore	ADV
ijpds-2904	32	2	,	,	PUNCT
ijpds-2904	32	3	there	there	PRON
ijpds-2904	32	4	is	be	VERB
ijpds-2904	32	5	a	a	DET
ijpds-2904	32	6	need	need	NOUN
ijpds-2904	32	7	to	to	PART
ijpds-2904	32	8	put	put	VERB
ijpds-2904	32	9	an	an	DET
ijpds-2904	32	10	effort	effort	NOUN
ijpds-2904	32	11	in	in	ADP
ijpds-2904	32	12	developing	develop	VERB
ijpds-2904	32	13	less	less	ADV
ijpds-2904	32	14	toxic	toxic	ADJ
ijpds-2904	32	15	platinum	platinum	NOUN
ijpds-2904	32	16	derivatives	derivative	NOUN
ijpds-2904	32	17	[	[	X
ijpds-2904	32	18	10	10	NUM
ijpds-2904	32	19	]	]	PUNCT
ijpds-2904	32	20	.	.	PUNCT
ijpds-2904	33	1	action	action	NOUN
ijpds-2904	33	2	of	of	ADP
ijpds-2904	33	3	cisplatin	cisplatin	NOUN
ijpds-2904	33	4	on	on	ADP
ijpds-2904	33	5	cell	cell	NOUN
ijpds-2904	33	6	growth	growth	NOUN
ijpds-2904	33	7	was	be	AUX
ijpds-2904	33	8	unexpectedly	unexpectedly	ADV
ijpds-2904	33	9	discovered	discover	VERB
ijpds-2904	33	10	by	by	ADP
ijpds-2904	33	11	rosenberg	rosenberg	PROPN
ijpds-2904	33	12	in	in	ADP
ijpds-2904	33	13	1965	1965	NUM
ijpds-2904	33	14	by	by	ADP
ijpds-2904	33	15	investigating	investigate	VERB
ijpds-2904	33	16	the	the	DET
ijpds-2904	33	17	effects	effect	NOUN
ijpds-2904	33	18	of	of	ADP
ijpds-2904	33	19	an	an	DET
ijpds-2904	33	20	electric	electric	ADJ
ijpds-2904	33	21	field	field	NOUN
ijpds-2904	33	22	on	on	ADP
ijpds-2904	33	23	the	the	DET
ijpds-2904	33	24	growth	growth	NOUN
ijpds-2904	33	25	of	of	ADP
ijpds-2904	33	26	escherichia	escherichia	NOUN
ijpds-2904	33	27	coli	coli	NOUN
ijpds-2904	33	28	bacteria	bacteria	NOUN
ijpds-2904	34	1	[	[	X
ijpds-2904	34	2	11	11	NUM
ijpds-2904	34	3	]	]	PUNCT
ijpds-2904	34	4	.	.	PUNCT
ijpds-2904	35	1	when	when	SCONJ
ijpds-2904	35	2	placed	place	VERB
ijpds-2904	35	3	in	in	ADP
ijpds-2904	35	4	an	an	DET
ijpds-2904	35	5	electric	electric	ADJ
ijpds-2904	35	6	field	field	NOUN
ijpds-2904	35	7	using	use	VERB
ijpds-2904	35	8	platinum	platinum	NOUN
ijpds-2904	35	9	-	-	PUNCT
ijpds-2904	35	10	conducting	conduct	VERB
ijpds-2904	35	11	plates	plate	NOUN
ijpds-2904	35	12	,	,	PUNCT
ijpds-2904	35	13	bacteria	bacteria	NOUN
ijpds-2904	35	14	ceased	cease	VERB
ijpds-2904	35	15	to	to	PART
ijpds-2904	35	16	divide	divide	VERB
ijpds-2904	35	17	.	.	PUNCT
ijpds-2904	36	1	rosenberg	rosenberg	PROPN
ijpds-2904	36	2	hypothesized	hypothesize	VERB
ijpds-2904	36	3	that	that	SCONJ
ijpds-2904	36	4	if	if	SCONJ
ijpds-2904	36	5	cisplatin	cisplatin	NOUN
ijpds-2904	36	6	could	could	AUX
ijpds-2904	36	7	inhibit	inhibit	VERB
ijpds-2904	36	8	bacterial	bacterial	ADJ
ijpds-2904	36	9	cell	cell	NOUN
ijpds-2904	36	10	division	division	NOUN
ijpds-2904	36	11	it	it	PRON
ijpds-2904	36	12	could	could	AUX
ijpds-2904	36	13	also	also	ADV
ijpds-2904	36	14	suppress	suppress	VERB
ijpds-2904	36	15	tumor	tumor	NOUN
ijpds-2904	36	16	cell	cell	NOUN
ijpds-2904	36	17	growth	growth	NOUN
ijpds-2904	36	18	.	.	PUNCT
ijpds-2904	37	1	cisplatin	cisplatin	NOUN
ijpds-2904	37	2	was	be	AUX
ijpds-2904	37	3	approved	approve	VERB
ijpds-2904	37	4	by	by	ADP
ijpds-2904	37	5	the	the	DET
ijpds-2904	37	6	fda	fda	PROPN
ijpds-2904	37	7	i	i	PRON
ijpds-2904	37	8	mailto:gpsinghcologist@hotmail.com	mailto:gpsinghcologist@hotmail.com	VERB
ijpds-2904	37	9	sakshi	sakshi	PROPN
ijpds-2904	37	10	and	and	CCONJ
ijpds-2904	37	11	singh	singh	PROPN
ijpds-2904	37	12	cisplatin	cisplatin	NOUN
ijpds-2904	37	13	induced	induce	VERB
ijpds-2904	37	14	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	37	15	vol	vol	NOUN
ijpds-2904	37	16	1	1	NUM
ijpds-2904	38	1	|	|	NOUN
ijpds-2904	38	2	issue	issue	VERB
ijpds-2904	38	3	1	1	NUM
ijpds-2904	38	4	|	|	ADV
ijpds-2904	38	5	apr	apr	ADV
ijpds-2904	38	6	–	–	PUNCT
ijpds-2904	38	7	jun	jun	PROPN
ijpds-2904	38	8	2022	2022	NUM
ijpds-2904	38	9	indian	indian	PROPN
ijpds-2904	38	10	j	j	PROPN
ijpds-2904	38	11	pharm	pharm	PROPN
ijpds-2904	38	12	drug	drug	PROPN
ijpds-2904	38	13	studies	study	NOUN
ijpds-2904	38	14	|	|	ADV
ijpds-2904	38	15	6	6	NUM
ijpds-2904	38	16	in	in	ADP
ijpds-2904	38	17	1978	1978	NUM
ijpds-2904	38	18	for	for	ADP
ijpds-2904	38	19	the	the	DET
ijpds-2904	38	20	treatment	treatment	NOUN
ijpds-2904	38	21	of	of	ADP
ijpds-2904	38	22	metastatic	metastatic	ADJ
ijpds-2904	38	23	testicular	testicular	NOUN
ijpds-2904	38	24	or	or	CCONJ
ijpds-2904	38	25	ovarian	ovarian	ADJ
ijpds-2904	38	26	cancer	cancer	NOUN
ijpds-2904	38	27	and	and	CCONJ
ijpds-2904	38	28	is	be	AUX
ijpds-2904	38	29	also	also	ADV
ijpds-2904	38	30	administered	administer	VERB
ijpds-2904	38	31	for	for	ADP
ijpds-2904	38	32	many	many	ADJ
ijpds-2904	38	33	other	other	ADJ
ijpds-2904	38	34	types	type	NOUN
ijpds-2904	38	35	of	of	ADP
ijpds-2904	38	36	solid	solid	ADJ
ijpds-2904	38	37	tumors	tumor	NOUN
ijpds-2904	38	38	[	[	X
ijpds-2904	38	39	12	12	NUM
ijpds-2904	38	40	]	]	PUNCT
ijpds-2904	38	41	.	.	PUNCT
ijpds-2904	39	1	a	a	DET
ijpds-2904	39	2	common	common	ADJ
ijpds-2904	39	3	event	event	NOUN
ijpds-2904	39	4	happening	happen	VERB
ijpds-2904	39	5	when	when	SCONJ
ijpds-2904	39	6	platinating	platinating	NOUN
ijpds-2904	39	7	agents	agent	NOUN
ijpds-2904	39	8	enter	enter	VERB
ijpds-2904	39	9	a	a	DET
ijpds-2904	39	10	cell	cell	NOUN
ijpds-2904	39	11	is	be	AUX
ijpds-2904	39	12	their	their	PRON
ijpds-2904	39	13	aquation	aquation	NOUN
ijpds-2904	39	14	that	that	PRON
ijpds-2904	39	15	is	be	AUX
ijpds-2904	39	16	losing	lose	VERB
ijpds-2904	39	17	of	of	ADP
ijpds-2904	39	18	chloride	chloride	NOUN
ijpds-2904	39	19	or	or	CCONJ
ijpds-2904	39	20	oxalate	oxalate	NOUN
ijpds-2904	39	21	ions	ion	NOUN
ijpds-2904	39	22	and	and	CCONJ
ijpds-2904	39	23	gaining	gain	VERB
ijpds-2904	39	24	two	two	NUM
ijpds-2904	39	25	water	water	NOUN
ijpds-2904	39	26	molecules	molecule	NOUN
ijpds-2904	39	27	to	to	PART
ijpds-2904	39	28	form	form	VERB
ijpds-2904	39	29	aquaions	aquaion	NOUN
ijpds-2904	39	30	.	.	PUNCT
ijpds-2904	40	1	the	the	DET
ijpds-2904	40	2	low	low	ADJ
ijpds-2904	40	3	intracellular	intracellular	ADJ
ijpds-2904	40	4	concentration	concentration	NOUN
ijpds-2904	40	5	of	of	ADP
ijpds-2904	40	6	chloride	chloride	NOUN
ijpds-2904	40	7	ions	ion	NOUN
ijpds-2904	40	8	facilitates	facilitate	VERB
ijpds-2904	40	9	this	this	DET
ijpds-2904	40	10	process	process	NOUN
ijpds-2904	40	11	[	[	X
ijpds-2904	40	12	13	13	NUM
ijpds-2904	40	13	]	]	PUNCT
ijpds-2904	40	14	.	.	PUNCT
ijpds-2904	41	1	positively	positively	ADV
ijpds-2904	41	2	charged	charge	VERB
ijpds-2904	41	3	aquated	aquate	VERB
ijpds-2904	41	4	form	form	NOUN
ijpds-2904	41	5	is	be	AUX
ijpds-2904	41	6	more	more	ADV
ijpds-2904	41	7	reactive	reactive	ADJ
ijpds-2904	41	8	to	to	ADP
ijpds-2904	41	9	the	the	DET
ijpds-2904	41	10	cellular	cellular	ADJ
ijpds-2904	41	11	targets	target	NOUN
ijpds-2904	41	12	,	,	PUNCT
ijpds-2904	41	13	such	such	ADJ
ijpds-2904	41	14	as	as	ADP
ijpds-2904	41	15	nucleophilic	nucleophilic	ADJ
ijpds-2904	41	16	molecules	molecule	NOUN
ijpds-2904	41	17	within	within	ADP
ijpds-2904	41	18	the	the	DET
ijpds-2904	41	19	cell	cell	NOUN
ijpds-2904	41	20	,	,	PUNCT
ijpds-2904	41	21	including	include	VERB
ijpds-2904	41	22	dna	dna	PROPN
ijpds-2904	41	23	,	,	PUNCT
ijpds-2904	41	24	rna	rna	NOUN
ijpds-2904	41	25	,	,	PUNCT
ijpds-2904	41	26	and	and	CCONJ
ijpds-2904	41	27	proteins	protein	NOUN
ijpds-2904	41	28	[	[	X
ijpds-2904	41	29	14	14	NUM
ijpds-2904	41	30	]	]	PUNCT
ijpds-2904	41	31	.	.	PUNCT
ijpds-2904	42	1	it	it	PRON
ijpds-2904	42	2	is	be	AUX
ijpds-2904	42	3	generally	generally	ADV
ijpds-2904	42	4	accepted	accept	VERB
ijpds-2904	42	5	that	that	SCONJ
ijpds-2904	42	6	dna	dna	PROPN
ijpds-2904	42	7	is	be	AUX
ijpds-2904	42	8	the	the	DET
ijpds-2904	42	9	preferential	preferential	ADJ
ijpds-2904	42	10	cytotoxic	cytotoxic	ADJ
ijpds-2904	42	11	target	target	NOUN
ijpds-2904	42	12	for	for	ADP
ijpds-2904	42	13	cisplatin	cisplatin	NOUN
ijpds-2904	42	14	and	and	CCONJ
ijpds-2904	42	15	other	other	ADJ
ijpds-2904	42	16	platinating	platinate	VERB
ijpds-2904	42	17	agents	agent	NOUN
ijpds-2904	42	18	:	:	PUNCT
ijpds-2904	42	19	these	these	DET
ijpds-2904	42	20	substances	substance	NOUN
ijpds-2904	42	21	bind	bind	VERB
ijpds-2904	42	22	preferentially	preferentially	ADV
ijpds-2904	42	23	the	the	DET
ijpds-2904	42	24	imidazole	imidazole	NOUN
ijpds-2904	42	25	ring	ring	NOUN
ijpds-2904	42	26	of	of	ADP
ijpds-2904	42	27	the	the	DET
ijpds-2904	42	28	purines	purine	NOUN
ijpds-2904	42	29	guanosine	guanosine	VERB
ijpds-2904	42	30	and	and	CCONJ
ijpds-2904	42	31	adenosine	adenosine	VERB
ijpds-2904	42	32	forming	form	VERB
ijpds-2904	42	33	monoadducts	monoadduct	NOUN
ijpds-2904	42	34	,	,	PUNCT
ijpds-2904	42	35	intrastrand	intrastrand	ADJ
ijpds-2904	42	36	crosslinks	crosslink	NOUN
ijpds-2904	42	37	,	,	PUNCT
ijpds-2904	42	38	and	and	CCONJ
ijpds-2904	42	39	interstrand	interstrand	NOUN
ijpds-2904	42	40	crosslinks	crosslink	NOUN
ijpds-2904	42	41	[	[	X
ijpds-2904	42	42	15	15	NUM
ijpds-2904	42	43	]	]	PUNCT
ijpds-2904	42	44	.	.	PUNCT
ijpds-2904	43	1	all	all	DET
ijpds-2904	43	2	crosslinks	crosslink	NOUN
ijpds-2904	43	3	distort	distort	VERB
ijpds-2904	43	4	the	the	DET
ijpds-2904	43	5	structure	structure	NOUN
ijpds-2904	43	6	of	of	ADP
ijpds-2904	43	7	the	the	DET
ijpds-2904	43	8	dna	dna	PROPN
ijpds-2904	43	9	duplex	duplex	NOUN
ijpds-2904	43	10	and	and	CCONJ
ijpds-2904	43	11	begin	begin	VERB
ijpds-2904	43	12	the	the	DET
ijpds-2904	43	13	dna	dna	PROPN
ijpds-2904	43	14	damage	damage	NOUN
ijpds-2904	43	15	response	response	NOUN
ijpds-2904	43	16	signaling	signal	VERB
ijpds-2904	43	17	,	,	PUNCT
ijpds-2904	43	18	resulting	result	VERB
ijpds-2904	43	19	in	in	ADP
ijpds-2904	43	20	cell	cell	NOUN
ijpds-2904	43	21	cycle	cycle	NOUN
ijpds-2904	43	22	arrest	arrest	NOUN
ijpds-2904	43	23	and	and	CCONJ
ijpds-2904	43	24	apoptosis	apoptosis	NOUN
ijpds-2904	43	25	[	[	X
ijpds-2904	43	26	16	16	NUM
ijpds-2904	43	27	]	]	PUNCT
ijpds-2904	43	28	.	.	PUNCT
ijpds-2904	44	1	cisplatin	cisplatin	NOUN
ijpds-2904	44	2	toxicity	toxicity	NOUN
ijpds-2904	44	3	cisplatin	cisplatin	NOUN
ijpds-2904	44	4	treatment	treatment	NOUN
ijpds-2904	44	5	,	,	PUNCT
ijpds-2904	44	6	even	even	ADV
ijpds-2904	44	7	though	though	SCONJ
ijpds-2904	44	8	effective	effective	ADJ
ijpds-2904	44	9	against	against	ADP
ijpds-2904	44	10	tumors	tumor	NOUN
ijpds-2904	44	11	,	,	PUNCT
ijpds-2904	44	12	has	have	VERB
ijpds-2904	44	13	severe	severe	ADJ
ijpds-2904	44	14	side	side	NOUN
ijpds-2904	44	15	-	-	PUNCT
ijpds-2904	44	16	effects	effect	NOUN
ijpds-2904	44	17	such	such	ADJ
ijpds-2904	44	18	as	as	ADP
ijpds-2904	44	19	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	44	20	,	,	PUNCT
ijpds-2904	44	21	which	which	PRON
ijpds-2904	44	22	is	be	AUX
ijpds-2904	44	23	often	often	ADV
ijpds-2904	44	24	doselimiting	doselimite	VERB
ijpds-2904	44	25	,	,	PUNCT
ijpds-2904	44	26	ototoxicity	ototoxicity	NOUN
ijpds-2904	44	27	,	,	PUNCT
ijpds-2904	44	28	and	and	CCONJ
ijpds-2904	44	29	peripheral	peripheral	ADJ
ijpds-2904	44	30	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	44	31	[	[	X
ijpds-2904	44	32	5	5	NUM
ijpds-2904	44	33	]	]	PUNCT
ijpds-2904	44	34	.	.	PUNCT
ijpds-2904	45	1	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	45	2	in	in	ADP
ijpds-2904	45	3	patients	patient	NOUN
ijpds-2904	45	4	cisplatin	cisplatin	NOUN
ijpds-2904	45	5	-	-	PUNCT
ijpds-2904	45	6	induced	induce	VERB
ijpds-2904	45	7	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	45	8	manifests	manifest	NOUN
ijpds-2904	45	9	acutely	acutely	ADV
ijpds-2904	45	10	and/or	and/or	CCONJ
ijpds-2904	45	11	chronically	chronically	ADV
ijpds-2904	45	12	.	.	PUNCT
ijpds-2904	46	1	clinically	clinically	ADV
ijpds-2904	46	2	,	,	PUNCT
ijpds-2904	46	3	cisplatin	cisplatin	NOUN
ijpds-2904	46	4	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	46	5	develops	develop	VERB
ijpds-2904	46	6	after	after	ADP
ijpds-2904	46	7	10	10	NUM
ijpds-2904	46	8	days	day	NOUN
ijpds-2904	46	9	of	of	ADP
ijpds-2904	46	10	cisplatin	cisplatin	NOUN
ijpds-2904	46	11	administration	administration	NOUN
ijpds-2904	46	12	and	and	CCONJ
ijpds-2904	46	13	is	be	AUX
ijpds-2904	46	14	manifested	manifest	VERB
ijpds-2904	46	15	as	as	ADP
ijpds-2904	46	16	lower	low	ADJ
ijpds-2904	46	17	glomerular	glomerular	ADJ
ijpds-2904	46	18	filtration	filtration	NOUN
ijpds-2904	46	19	rate	rate	NOUN
ijpds-2904	46	20	,	,	PUNCT
ijpds-2904	46	21	higher	high	ADJ
ijpds-2904	46	22	serum	serum	NOUN
ijpds-2904	46	23	creatinine	creatinine	NOUN
ijpds-2904	46	24	,	,	PUNCT
ijpds-2904	46	25	and	and	CCONJ
ijpds-2904	46	26	reduced	reduce	VERB
ijpds-2904	46	27	serum	serum	NOUN
ijpds-2904	46	28	magnesium	magnesium	NOUN
ijpds-2904	46	29	and	and	CCONJ
ijpds-2904	46	30	potassium	potassium	NOUN
ijpds-2904	46	31	levels	level	NOUN
ijpds-2904	46	32	interestingly	interestingly	ADV
ijpds-2904	46	33	,	,	PUNCT
ijpds-2904	46	34	striking	strike	VERB
ijpds-2904	46	35	differences	difference	NOUN
ijpds-2904	46	36	between	between	ADP
ijpds-2904	46	37	patients	patient	NOUN
ijpds-2904	46	38	in	in	ADP
ijpds-2904	46	39	susceptibility	susceptibility	NOUN
ijpds-2904	46	40	to	to	ADP
ijpds-2904	46	41	progressive	progressive	ADJ
ijpds-2904	46	42	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	46	43	are	be	AUX
ijpds-2904	46	44	even	even	ADV
ijpds-2904	46	45	though	though	SCONJ
ijpds-2904	46	46	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	46	47	can	can	AUX
ijpds-2904	46	48	be	be	AUX
ijpds-2904	46	49	controlled	control	VERB
ijpds-2904	46	50	by	by	ADP
ijpds-2904	46	51	diuretics	diuretic	NOUN
ijpds-2904	46	52	and	and	CCONJ
ijpds-2904	46	53	prehydration	prehydration	NOUN
ijpds-2904	46	54	of	of	ADP
ijpds-2904	46	55	patients	patient	NOUN
ijpds-2904	46	56	[	[	X
ijpds-2904	46	57	17	17	NUM
ijpds-2904	46	58	]	]	PUNCT
ijpds-2904	46	59	.	.	PUNCT
ijpds-2904	47	1	it	it	PRON
ijpds-2904	47	2	is	be	AUX
ijpds-2904	47	3	recognized	recognize	VERB
ijpds-2904	47	4	that	that	SCONJ
ijpds-2904	47	5	the	the	DET
ijpds-2904	47	6	prevalence	prevalence	NOUN
ijpds-2904	47	7	of	of	ADP
ijpds-2904	47	8	cisplatin	cisplatin	NOUN
ijpds-2904	47	9	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	47	10	is	be	AUX
ijpds-2904	47	11	high	high	ADJ
ijpds-2904	47	12	,	,	PUNCT
ijpds-2904	47	13	occurring	occur	VERB
ijpds-2904	47	14	in	in	ADP
ijpds-2904	47	15	about	about	ADV
ijpds-2904	47	16	one	one	NUM
ijpds-2904	47	17	third	third	NOUN
ijpds-2904	47	18	of	of	ADP
ijpds-2904	47	19	patients	patient	NOUN
ijpds-2904	47	20	undergoing	undergo	VERB
ijpds-2904	47	21	cisplatin	cisplatin	NOUN
ijpds-2904	47	22	treatment	treatment	NOUN
ijpds-2904	47	23	in	in	ADP
ijpds-2904	47	24	animal	animal	NOUN
ijpds-2904	47	25	studies	study	NOUN
ijpds-2904	47	26	it	it	PRON
ijpds-2904	47	27	has	have	AUX
ijpds-2904	47	28	been	be	AUX
ijpds-2904	47	29	shown	show	VERB
ijpds-2904	47	30	that	that	SCONJ
ijpds-2904	47	31	the	the	DET
ijpds-2904	47	32	kidney	kidney	NOUN
ijpds-2904	47	33	accumulates	accumulate	VERB
ijpds-2904	47	34	more	more	ADJ
ijpds-2904	47	35	cisplatin	cisplatin	NOUN
ijpds-2904	47	36	than	than	ADP
ijpds-2904	47	37	other	other	ADJ
ijpds-2904	47	38	organs	organ	NOUN
ijpds-2904	47	39	and	and	CCONJ
ijpds-2904	47	40	that	that	SCONJ
ijpds-2904	47	41	the	the	DET
ijpds-2904	47	42	proximal	proximal	ADJ
ijpds-2904	47	43	tubules	tubule	NOUN
ijpds-2904	47	44	are	be	AUX
ijpds-2904	47	45	principally	principally	ADV
ijpds-2904	47	46	damaged	damage	VERB
ijpds-2904	47	47	by	by	ADP
ijpds-2904	47	48	cisplatin	cisplatin	NOUN
ijpds-2904	47	49	[	[	X
ijpds-2904	47	50	18	18	NUM
ijpds-2904	47	51	]	]	PUNCT
ijpds-2904	47	52	.	.	PUNCT
ijpds-2904	48	1	ototoxicity	ototoxicity	NOUN
ijpds-2904	48	2	ototoxicity	ototoxicity	NOUN
ijpds-2904	48	3	is	be	AUX
ijpds-2904	48	4	an9	an9	ADV
ijpds-2904	48	5	untypical	untypical	ADJ
ijpds-2904	48	6	side	side	NOUN
ijpds-2904	48	7	effect	effect	NOUN
ijpds-2904	48	8	for	for	ADP
ijpds-2904	48	9	a	a	DET
ijpds-2904	48	10	chemotherapeutic	chemotherapeutic	ADJ
ijpds-2904	48	11	drug	drug	NOUN
ijpds-2904	48	12	.	.	PUNCT
ijpds-2904	49	1	cisplatin	cisplatin	NOUN
ijpds-2904	49	2	treatment	treatment	NOUN
ijpds-2904	49	3	causes	cause	VERB
ijpds-2904	49	4	a	a	DET
ijpds-2904	49	5	hearing	hearing	NOUN
ijpds-2904	49	6	loss	loss	NOUN
ijpds-2904	49	7	,	,	PUNCT
ijpds-2904	49	8	which	which	PRON
ijpds-2904	49	9	can	can	AUX
ijpds-2904	49	10	also	also	ADV
ijpds-2904	49	11	lead	lead	VERB
ijpds-2904	49	12	to	to	ADP
ijpds-2904	49	13	deafness	deafness	NOUN
ijpds-2904	49	14	[	[	X
ijpds-2904	49	15	19	19	NUM
ijpds-2904	49	16	]	]	PUNCT
ijpds-2904	49	17	.	.	PUNCT
ijpds-2904	50	1	ototoxicity	ototoxicity	NOUN
ijpds-2904	50	2	remains	remain	VERB
ijpds-2904	50	3	an	an	DET
ijpds-2904	50	4	unresolved	unresolved	ADJ
ijpds-2904	50	5	clinical	clinical	ADJ
ijpds-2904	50	6	problem	problem	NOUN
ijpds-2904	50	7	especially	especially	ADV
ijpds-2904	50	8	in	in	ADP
ijpds-2904	50	9	infants	infant	NOUN
ijpds-2904	50	10	and	and	CCONJ
ijpds-2904	50	11	younger	young	ADJ
ijpds-2904	50	12	children	child	NOUN
ijpds-2904	50	13	,	,	PUNCT
ijpds-2904	50	14	where	where	SCONJ
ijpds-2904	50	15	it	it	PRON
ijpds-2904	50	16	leads	lead	VERB
ijpds-2904	50	17	to	to	ADP
ijpds-2904	50	18	a	a	DET
ijpds-2904	50	19	considerable	considerable	ADJ
ijpds-2904	50	20	risk	risk	NOUN
ijpds-2904	50	21	of	of	ADP
ijpds-2904	50	22	delayed	delay	VERB
ijpds-2904	50	23	language	language	NOUN
ijpds-2904	50	24	development	development	NOUN
ijpds-2904	50	25	due	due	ADP
ijpds-2904	50	26	to	to	ADP
ijpds-2904	50	27	impaired	impair	VERB
ijpds-2904	50	28	perception	perception	NOUN
ijpds-2904	50	29	of	of	ADP
ijpds-2904	50	30	higher	high	ADJ
ijpds-2904	50	31	frequency	frequency	NOUN
ijpds-2904	50	32	consonant	consonant	NOUN
ijpds-2904	50	33	sounds	sound	NOUN
ijpds-2904	50	34	that	that	PRON
ijpds-2904	50	35	is	be	AUX
ijpds-2904	50	36	of	of	ADP
ijpds-2904	50	37	great	great	ADJ
ijpds-2904	50	38	importance	importance	NOUN
ijpds-2904	50	39	in	in	ADP
ijpds-2904	50	40	the	the	DET
ijpds-2904	50	41	presence	presence	NOUN
ijpds-2904	50	42	of	of	ADP
ijpds-2904	50	43	background	background	NOUN
ijpds-2904	50	44	noise	noise	NOUN
ijpds-2904	50	45	[	[	X
ijpds-2904	50	46	20	20	NUM
ijpds-2904	50	47	]	]	PUNCT
ijpds-2904	50	48	.	.	PUNCT
ijpds-2904	51	1	incidence	incidence	NOUN
ijpds-2904	51	2	of	of	ADP
ijpds-2904	51	3	ototoxicity	ototoxicity	NOUN
ijpds-2904	51	4	is	be	AUX
ijpds-2904	51	5	reported	report	VERB
ijpds-2904	51	6	to	to	PART
ijpds-2904	51	7	be	be	AUX
ijpds-2904	51	8	between	between	ADP
ijpds-2904	51	9	23	23	NUM
ijpds-2904	51	10	and	and	CCONJ
ijpds-2904	51	11	50	50	NUM
ijpds-2904	51	12	%	%	NOUN
ijpds-2904	51	13	in	in	ADP
ijpds-2904	51	14	adults	adult	NOUN
ijpds-2904	51	15	and	and	CCONJ
ijpds-2904	51	16	greater	great	ADJ
ijpds-2904	51	17	than	than	ADP
ijpds-2904	51	18	50	50	NUM
ijpds-2904	51	19	%	%	NOUN
ijpds-2904	51	20	in	in	ADP
ijpds-2904	51	21	children	child	NOUN
ijpds-2904	51	22	,	,	PUNCT
ijpds-2904	51	23	clinical	clinical	ADJ
ijpds-2904	51	24	symptoms	symptom	NOUN
ijpds-2904	51	25	of	of	ADP
ijpds-2904	51	26	toxicity	toxicity	NOUN
ijpds-2904	51	27	consist	consist	NOUN
ijpds-2904	51	28	of	of	ADP
ijpds-2904	51	29	bilateral	bilateral	ADJ
ijpds-2904	51	30	symmetrical	symmetrical	ADJ
ijpds-2904	51	31	high	high	ADJ
ijpds-2904	51	32	-	-	PUNCT
ijpds-2904	51	33	frequency	frequency	NOUN
ijpds-2904	51	34	sensori	sensori	NOUN
ijpds-2904	51	35	-	-	PUNCT
ijpds-2904	51	36	neural	neural	ADJ
ijpds-2904	51	37	hearing	hearing	NOUN
ijpds-2904	51	38	loss	loss	NOUN
ijpds-2904	51	39	,	,	PUNCT
ijpds-2904	51	40	ear	ear	NOUN
ijpds-2904	51	41	pain	pain	NOUN
ijpds-2904	51	42	,	,	PUNCT
ijpds-2904	51	43	or	or	CCONJ
ijpds-2904	51	44	tinnitus	tinnitus	NOUN
ijpds-2904	52	1	[	[	X
ijpds-2904	52	2	21	21	NUM
ijpds-2904	52	3	]	]	PUNCT
ijpds-2904	52	4	.	.	PUNCT
ijpds-2904	53	1	damage	damage	NOUN
ijpds-2904	53	2	induced	induce	VERB
ijpds-2904	53	3	by	by	ADP
ijpds-2904	53	4	cisplatin	cisplatin	NOUN
ijpds-2904	53	5	begins	begin	VERB
ijpds-2904	53	6	at	at	ADP
ijpds-2904	53	7	the	the	DET
ijpds-2904	53	8	cochlea	cochlea	NOUN
ijpds-2904	53	9	base	base	NOUN
ijpds-2904	53	10	,	,	PUNCT
ijpds-2904	53	11	where	where	SCONJ
ijpds-2904	53	12	high	high	ADJ
ijpds-2904	53	13	-	-	PUNCT
ijpds-2904	53	14	frequency	frequency	NOUN
ijpds-2904	53	15	sounds	sound	NOUN
ijpds-2904	53	16	are	be	AUX
ijpds-2904	53	17	processed	process	VERB
ijpds-2904	53	18	,	,	PUNCT
ijpds-2904	53	19	and	and	CCONJ
ijpds-2904	53	20	proceeds	proceed	NOUN
ijpds-2904	53	21	towards	towards	ADP
ijpds-2904	53	22	the	the	DET
ijpds-2904	53	23	apex	apex	NOUN
ijpds-2904	53	24	,	,	PUNCT
ijpds-2904	53	25	affecting	affect	VERB
ijpds-2904	53	26	also	also	ADV
ijpds-2904	53	27	hearing	hear	VERB
ijpds-2904	53	28	at	at	ADP
ijpds-2904	53	29	lower	low	ADJ
ijpds-2904	53	30	frequencies	frequency	NOUN
ijpds-2904	53	31	as	as	ADP
ijpds-2904	53	32	the	the	DET
ijpds-2904	53	33	cumulative	cumulative	ADJ
ijpds-2904	53	34	dose	dose	NOUN
ijpds-2904	53	35	increases	increase	NOUN
ijpds-2904	53	36	[	[	X
ijpds-2904	53	37	21	21	NUM
ijpds-2904	53	38	]	]	PUNCT
ijpds-2904	53	39	.	.	PUNCT
ijpds-2904	54	1	in	in	ADP
ijpds-2904	54	2	the	the	DET
ijpds-2904	54	3	cochlea	cochlea	NOUN
ijpds-2904	54	4	,	,	PUNCT
ijpds-2904	54	5	cisplatin	cisplatin	NOUN
ijpds-2904	54	6	seems	seem	VERB
ijpds-2904	54	7	to	to	PART
ijpds-2904	54	8	induce	induce	VERB
ijpds-2904	54	9	the	the	DET
ijpds-2904	54	10	generation	generation	NOUN
ijpds-2904	54	11	of	of	ADP
ijpds-2904	54	12	reactive	reactive	ADJ
ijpds-2904	54	13	oxygen	oxygen	NOUN
ijpds-2904	54	14	species	specie	NOUN
ijpds-2904	54	15	and/or	and/or	CCONJ
ijpds-2904	54	16	the	the	DET
ijpds-2904	54	17	depletion	depletion	NOUN
ijpds-2904	54	18	of	of	ADP
ijpds-2904	54	19	scavenging	scavenge	VERB
ijpds-2904	54	20	enzymes	enzyme	NOUN
ijpds-2904	54	21	causing	cause	VERB
ijpds-2904	54	22	cell	cell	NOUN
ijpds-2904	54	23	apoptosis	apoptosis	NOUN
ijpds-2904	54	24	[	[	X
ijpds-2904	54	25	22	22	NUM
ijpds-2904	54	26	]	]	PUNCT
ijpds-2904	54	27	.	.	PUNCT
ijpds-2904	55	1	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	55	2	most	most	ADJ
ijpds-2904	55	3	patients	patient	NOUN
ijpds-2904	55	4	treated	treat	VERB
ijpds-2904	55	5	with	with	ADP
ijpds-2904	55	6	cisplatin	cisplatin	NOUN
ijpds-2904	55	7	develop	develop	VERB
ijpds-2904	55	8	a	a	DET
ijpds-2904	55	9	symptomatic	symptomatic	ADJ
ijpds-2904	55	10	and	and	CCONJ
ijpds-2904	55	11	clinically	clinically	ADV
ijpds-2904	55	12	detectable	detectable	ADJ
ijpds-2904	55	13	sensory	sensory	ADJ
ijpds-2904	55	14	neuropathy	neuropathy	ADJ
ijpds-2904	55	15	,	,	PUNCT
ijpds-2904	55	16	caused	cause	VERB
ijpds-2904	55	17	by	by	ADP
ijpds-2904	55	18	its	its	PRON
ijpds-2904	55	19	preferential	preferential	ADJ
ijpds-2904	55	20	uptake	uptake	NOUN
ijpds-2904	55	21	in	in	ADP
ijpds-2904	55	22	the	the	DET
ijpds-2904	55	23	dorsal	dorsal	NOUN
ijpds-2904	55	24	root	root	NOUN
ijpds-2904	55	25	ganglia	ganglion	NOUN
ijpds-2904	55	26	,	,	PUNCT
ijpds-2904	55	27	which	which	PRON
ijpds-2904	55	28	produces	produce	VERB
ijpds-2904	55	29	a	a	DET
ijpds-2904	55	30	dose	dose	NOUN
ijpds-2904	55	31	-	-	PUNCT
ijpds-2904	55	32	related	relate	VERB
ijpds-2904	55	33	large	large	ADJ
ijpds-2904	55	34	fibre	fibre	NOUN
ijpds-2904	55	35	sensory	sensory	ADJ
ijpds-2904	55	36	neuropathy	neuropathy	ADJ
ijpds-2904	55	37	[	[	X
ijpds-2904	55	38	5	5	NUM
ijpds-2904	55	39	]	]	PUNCT
ijpds-2904	55	40	.	.	PUNCT
ijpds-2904	56	1	symptoms	symptom	NOUN
ijpds-2904	56	2	include	include	VERB
ijpds-2904	56	3	unpleasant	unpleasant	ADJ
ijpds-2904	56	4	distal	distal	ADJ
ijpds-2904	56	5	paresthesias	paresthesia	NOUN
ijpds-2904	56	6	(	(	PUNCT
ijpds-2904	56	7	tingling	tingle	VERB
ijpds-2904	56	8	in	in	ADP
ijpds-2904	56	9	the	the	DET
ijpds-2904	56	10	extremities	extremity	NOUN
ijpds-2904	56	11	)	)	PUNCT
ijpds-2904	56	12	and	and	CCONJ
ijpds-2904	56	13	numbness	numbness	NOUN
ijpds-2904	56	14	,	,	PUNCT
ijpds-2904	56	15	associated	associate	VERB
ijpds-2904	56	16	with	with	ADP
ijpds-2904	56	17	large	large	ADJ
ijpds-2904	56	18	fibre	fibre	NOUN
ijpds-2904	56	19	sensory	sensory	ADJ
ijpds-2904	56	20	-loss	-loss	NOUN
ijpds-2904	56	21	(	(	PUNCT
ijpds-2904	56	22	reduced	reduce	VERB
ijpds-2904	56	23	vibration	vibration	NOUN
ijpds-2904	56	24	and	and	CCONJ
ijpds-2904	56	25	joint	joint	ADJ
ijpds-2904	56	26	position	position	NOUN
ijpds-2904	56	27	sensations	sensation	NOUN
ijpds-2904	56	28	)	)	PUNCT
ijpds-2904	56	29	and	and	CCONJ
ijpds-2904	56	30	diminished	diminish	VERB
ijpds-2904	56	31	or	or	CCONJ
ijpds-2904	56	32	absent	absent	ADJ
ijpds-2904	56	33	muscle	muscle	NOUN
ijpds-2904	56	34	stretch	stretch	NOUN
ijpds-2904	56	35	reflexes	reflex	NOUN
ijpds-2904	56	36	[	[	X
ijpds-2904	56	37	23	23	NUM
ijpds-2904	56	38	]	]	PUNCT
ijpds-2904	56	39	.	.	PUNCT
ijpds-2904	57	1	sensory	sensory	ADJ
ijpds-2904	57	2	ataxia	ataxia	NOUN
ijpds-2904	57	3	(	(	PUNCT
ijpds-2904	57	4	incoordination	incoordination	NOUN
ijpds-2904	57	5	)	)	PUNCT
ijpds-2904	57	6	may	may	AUX
ijpds-2904	57	7	be	be	AUX
ijpds-2904	57	8	disabling	disable	VERB
ijpds-2904	57	9	in	in	ADP
ijpds-2904	57	10	those	those	DET
ijpds-2904	57	11	patients	patient	NOUN
ijpds-2904	57	12	who	who	PRON
ijpds-2904	57	13	have	have	VERB
ijpds-2904	57	14	severe	severe	ADJ
ijpds-2904	57	15	neuropathy	neuropathy	ADJ
ijpds-2904	57	16	.	.	PUNCT
ijpds-2904	58	1	these	these	DET
ijpds-2904	58	2	symptoms	symptom	NOUN
ijpds-2904	58	3	may	may	AUX
ijpds-2904	58	4	appear	appear	VERB
ijpds-2904	58	5	as	as	ADV
ijpds-2904	58	6	soon	soon	ADV
ijpds-2904	58	7	as	as	ADP
ijpds-2904	58	8	one	one	NUM
ijpds-2904	58	9	month	month	NOUN
ijpds-2904	58	10	after	after	ADP
ijpds-2904	58	11	initiating	initiate	VERB
ijpds-2904	58	12	treatment	treatment	NOUN
ijpds-2904	58	13	[	[	X
ijpds-2904	58	14	24	24	NUM
ijpds-2904	58	15	]	]	PUNCT
ijpds-2904	58	16	.	.	PUNCT
ijpds-2904	59	1	the	the	DET
ijpds-2904	59	2	neuropathy	neuropathy	ADJ
ijpds-2904	59	3	may	may	AUX
ijpds-2904	59	4	only	only	ADV
ijpds-2904	59	5	partially	partially	ADV
ijpds-2904	59	6	recover	recover	VERB
ijpds-2904	59	7	or	or	CCONJ
ijpds-2904	59	8	not	not	PART
ijpds-2904	59	9	recover	recover	VERB
ijpds-2904	59	10	at	at	ADV
ijpds-2904	59	11	all	all	ADV
ijpds-2904	59	12	.	.	PUNCT
ijpds-2904	60	1	in	in	ADP
ijpds-2904	60	2	rodents	rodent	NOUN
ijpds-2904	60	3	,	,	PUNCT
ijpds-2904	60	4	cisplatin	cisplatin	NOUN
ijpds-2904	60	5	affects	affect	VERB
ijpds-2904	60	6	sensory	sensory	ADJ
ijpds-2904	60	7	nerve	nerve	NOUN
ijpds-2904	60	8	structure	structure	NOUN
ijpds-2904	60	9	and	and	CCONJ
ijpds-2904	60	10	function	function	NOUN
ijpds-2904	60	11	,	,	PUNCT
ijpds-2904	60	12	showing	show	VERB
ijpds-2904	60	13	preferential	preferential	ADJ
ijpds-2904	60	14	toxicity	toxicity	NOUN
ijpds-2904	60	15	to	to	ADP
ijpds-2904	60	16	large	large	ADJ
ijpds-2904	60	17	diameter	diameter	NOUN
ijpds-2904	60	18	neurons	neuron	NOUN
ijpds-2904	60	19	and	and	CCONJ
ijpds-2904	60	20	proprioceptive	proprioceptive	ADJ
ijpds-2904	60	21	sensory	sensory	ADJ
ijpds-2904	60	22	modalities	modality	NOUN
ijpds-2904	60	23	,	,	PUNCT
ijpds-2904	60	24	while	while	SCONJ
ijpds-2904	60	25	motor	motor	NOUN
ijpds-2904	60	26	nerves	nerve	NOUN
ijpds-2904	60	27	are	be	AUX
ijpds-2904	60	28	spared	spare	VERB
ijpds-2904	60	29	from	from	ADP
ijpds-2904	60	30	toxicity	toxicity	NOUN
ijpds-2904	60	31	.	.	PUNCT
ijpds-2904	61	1	the	the	DET
ijpds-2904	61	2	mechanism	mechanism	NOUN
ijpds-2904	61	3	of	of	ADP
ijpds-2904	61	4	platinum	platinum	NOUN
ijpds-2904	61	5	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	61	6	remains	remain	VERB
ijpds-2904	61	7	in	in	ADP
ijpds-2904	61	8	completely	completely	ADV
ijpds-2904	61	9	understood	understand	VERB
ijpds-2904	61	10	although	although	SCONJ
ijpds-2904	61	11	it	it	PRON
ijpds-2904	61	12	may	may	AUX
ijpds-2904	61	13	involve	involve	VERB
ijpds-2904	61	14	platinum	platinum	NOUN
ijpds-2904	61	15	accumulation	accumulation	NOUN
ijpds-2904	61	16	within	within	ADP
ijpds-2904	61	17	the	the	DET
ijpds-2904	61	18	dorsal	dorsal	NOUN
ijpds-2904	61	19	root	root	NOUN
ijpds-2904	61	20	ganglia	ganglia	NOUN
ijpds-2904	61	21	(	(	PUNCT
ijpds-2904	61	22	drg	drg	NOUN
ijpds-2904	61	23	)	)	PUNCT
ijpds-2904	61	24	leading	lead	VERB
ijpds-2904	61	25	to	to	ADP
ijpds-2904	61	26	atrophy	atrophy	NOUN
ijpds-2904	61	27	or	or	CCONJ
ijpds-2904	61	28	loss	loss	NOUN
ijpds-2904	61	29	of	of	ADP
ijpds-2904	61	30	peripheral	peripheral	ADJ
ijpds-2904	61	31	sensory	sensory	ADJ
ijpds-2904	61	32	neurons	neuron	NOUN
ijpds-2904	61	33	[	[	X
ijpds-2904	61	34	25	25	NUM
ijpds-2904	61	35	]	]	PUNCT
ijpds-2904	61	36	.	.	PUNCT
ijpds-2904	62	1	cellular	cellular	ADJ
ijpds-2904	62	2	transport	transport	NOUN
ijpds-2904	62	3	of	of	ADP
ijpds-2904	62	4	cisplatin	cisplatin	NOUN
ijpds-2904	62	5	several	several	ADJ
ijpds-2904	62	6	different	different	ADJ
ijpds-2904	62	7	transporters	transporter	NOUN
ijpds-2904	62	8	seem	seem	VERB
ijpds-2904	62	9	to	to	PART
ijpds-2904	62	10	be	be	AUX
ijpds-2904	62	11	involved	involve	VERB
ijpds-2904	62	12	in	in	ADP
ijpds-2904	62	13	the	the	DET
ijpds-2904	62	14	cellular	cellular	ADJ
ijpds-2904	62	15	transport	transport	NOUN
ijpds-2904	62	16	of	of	ADP
ijpds-2904	62	17	cisplatin	cisplatin	NOUN
ijpds-2904	62	18	:	:	PUNCT
ijpds-2904	62	19	ctr1	ctr1	PROPN
ijpds-2904	62	20	,	,	PUNCT
ijpds-2904	62	21	ctr2the	ctr2the	DET
ijpds-2904	62	22	p	p	ADJ
ijpds-2904	62	23	-	-	PUNCT
ijpds-2904	62	24	type	type	NOUN
ijpds-2904	62	25	coppertransporting	coppertransporte	VERB
ijpds-2904	62	26	atpases	atpase	NOUN
ijpds-2904	62	27	atp7a	atp7a	PUNCT
ijpds-2904	62	28	and	and	CCONJ
ijpds-2904	62	29	atp7b	atp7b	PROPN
ijpds-2904	62	30	,	,	PUNCT
ijpds-2904	62	31	oct2	oct2	NOUN
ijpds-2904	62	32	and	and	CCONJ
ijpds-2904	62	33	mate1	mate1	NOUN
ijpds-2904	63	1	[	[	X
ijpds-2904	63	2	5	5	NUM
ijpds-2904	63	3	]	]	PUNCT
ijpds-2904	63	4	.	.	PUNCT
ijpds-2904	64	1	copper	copper	NOUN
ijpds-2904	64	2	transporter	transporter	NOUN
ijpds-2904	64	3	1	1	NUM
ijpds-2904	64	4	(	(	PUNCT
ijpds-2904	64	5	ctr1	ctr1	PROPN
ijpds-2904	64	6	)	)	PUNCT
ijpds-2904	64	7	copper	copper	NOUN
ijpds-2904	64	8	transporter	transporter	NOUN
ijpds-2904	64	9	1	1	NUM
ijpds-2904	64	10	(	(	PUNCT
ijpds-2904	64	11	ctr1	ctr1	PROPN
ijpds-2904	64	12	,	,	PUNCT
ijpds-2904	64	13	solute	solute	NOUN
ijpds-2904	64	14	carrier	carrier	NOUN
ijpds-2904	64	15	31a1	31a1	NUM
ijpds-2904	64	16	-	-	PUNCT
ijpds-2904	64	17	slc31a1	slc31a1	NOUN
ijpds-2904	64	18	)	)	PUNCT
ijpds-2904	64	19	is	be	AUX
ijpds-2904	64	20	a	a	DET
ijpds-2904	64	21	membrane	membrane	NOUN
ijpds-2904	64	22	protein	protein	NOUN
ijpds-2904	64	23	that	that	PRON
ijpds-2904	64	24	plays	play	VERB
ijpds-2904	64	25	a	a	DET
ijpds-2904	64	26	significant	significant	ADJ
ijpds-2904	64	27	role	role	NOUN
ijpds-2904	64	28	in	in	ADP
ijpds-2904	64	29	the	the	DET
ijpds-2904	64	30	cellular	cellular	ADJ
ijpds-2904	64	31	cisplatin	cisplatin	NOUN
ijpds-2904	64	32	uptake	uptake	NOUN
ijpds-2904	64	33	.	.	PUNCT
ijpds-2904	65	1	down	down	ADP
ijpds-2904	65	2	-	-	PUNCT
ijpds-2904	65	3	regulation	regulation	NOUN
ijpds-2904	65	4	of	of	ADP
ijpds-2904	65	5	ctr1	ctr1	NOUN
ijpds-2904	65	6	extensively	extensively	ADV
ijpds-2904	65	7	reduced	reduce	VERB
ijpds-2904	65	8	cisplatin	cisplatin	NOUN
ijpds-2904	65	9	uptake	uptake	NOUN
ijpds-2904	65	10	in	in	ADP
ijpds-2904	65	11	yeast	yeast	NOUN
ijpds-2904	65	12	and	and	CCONJ
ijpds-2904	65	13	inmouse	inmouse	NOUN
ijpds-2904	65	14	embryonic	embryonic	NOUN
ijpds-2904	65	15	fibroblasts	fibroblast	NOUN
ijpds-2904	65	16	[	[	X
ijpds-2904	65	17	26	26	NUM
ijpds-2904	65	18	]	]	PUNCT
ijpds-2904	65	19	.	.	PUNCT
ijpds-2904	66	1	the	the	DET
ijpds-2904	66	2	natural	natural	ADJ
ijpds-2904	66	3	substrate	substrate	NOUN
ijpds-2904	66	4	of	of	ADP
ijpds-2904	66	5	ctr1	ctr1	NOUN
ijpds-2904	66	6	is	be	AUX
ijpds-2904	66	7	monovalent	monovalent	NOUN
ijpds-2904	66	8	copper	copper	NOUN
ijpds-2904	66	9	(	(	PUNCT
ijpds-2904	66	10	cu+	cu+	PROPN
ijpds-2904	66	11	)	)	PUNCT
ijpds-2904	66	12	.	.	PUNCT
ijpds-2904	67	1	cu+	cu+	PROPN
ijpds-2904	67	2	uptake	uptake	ADJ
ijpds-2904	67	3	by	by	ADP
ijpds-2904	67	4	ctr1	ctr1	PROPN
ijpds-2904	67	5	triggers	trigger	NOUN
ijpds-2904	67	6	transporter	transporter	NOUN
ijpds-2904	67	7	internalization	internalization	NOUN
ijpds-2904	67	8	[	[	X
ijpds-2904	67	9	27	27	NUM
ijpds-2904	67	10	]	]	PUNCT
ijpds-2904	67	11	.	.	PUNCT
ijpds-2904	68	1	however	however	ADV
ijpds-2904	68	2	,	,	PUNCT
ijpds-2904	68	3	whether	whether	SCONJ
ijpds-2904	68	4	this	this	DET
ijpds-2904	68	5	phenomenon	phenomenon	NOUN
ijpds-2904	68	6	also	also	ADV
ijpds-2904	68	7	happens	happen	VERB
ijpds-2904	68	8	upon	upon	SCONJ
ijpds-2904	68	9	cisplatin	cisplatin	NOUN
ijpds-2904	68	10	transport	transport	NOUN
ijpds-2904	68	11	is	be	AUX
ijpds-2904	68	12	debated	debate	VERB
ijpds-2904	68	13	.	.	PUNCT
ijpds-2904	69	1	as	as	SCONJ
ijpds-2904	69	2	observed	observe	VERB
ijpds-2904	69	3	for	for	ADP
ijpds-2904	69	4	cu+	cu+	PROPN
ijpds-2904	69	5	,	,	PUNCT
ijpds-2904	69	6	cisplatin	cisplatin	NOUN
ijpds-2904	69	7	binds	bind	VERB
ijpds-2904	69	8	to	to	ADP
ijpds-2904	69	9	methionine	methionine	NOUN
ijpds-2904	69	10	-	-	PUNCT
ijpds-2904	69	11	rich	rich	ADJ
ijpds-2904	69	12	motifs	motif	NOUN
ijpds-2904	69	13	of	of	ADP
ijpds-2904	69	14	the	the	DET
ijpds-2904	69	15	extracellular	extracellular	ADJ
ijpds-2904	69	16	domain	domain	NOUN
ijpds-2904	69	17	of	of	ADP
ijpds-2904	69	18	ctr1	ctr1	PROPN
ijpds-2904	69	19	.	.	PUNCT
ijpds-2904	70	1	ctr1	ctr1	PROPN
ijpds-2904	70	2	carries	carry	VERB
ijpds-2904	70	3	out	out	ADP
ijpds-2904	70	4	vital	vital	ADJ
ijpds-2904	70	5	physiological	physiological	ADJ
ijpds-2904	70	6	function	function	NOUN
ijpds-2904	70	7	supplying	supply	VERB
ijpds-2904	70	8	the	the	DET
ijpds-2904	70	9	cell	cell	NOUN
ijpds-2904	70	10	with	with	ADP
ijpds-2904	70	11	copper	copper	NOUN
ijpds-2904	70	12	,	,	PUNCT
ijpds-2904	70	13	which	which	PRON
ijpds-2904	70	14	is	be	AUX
ijpds-2904	70	15	an	an	DET
ijpds-2904	70	16	essential	essential	ADJ
ijpds-2904	70	17	cellular	cellular	ADJ
ijpds-2904	70	18	nutrient	nutrient	NOUN
ijpds-2904	70	19	used	use	VERB
ijpds-2904	70	20	in	in	ADP
ijpds-2904	70	21	a	a	DET
ijpds-2904	70	22	broad	broad	ADJ
ijpds-2904	70	23	range	range	NOUN
ijpds-2904	70	24	of	of	ADP
ijpds-2904	70	25	enzymatic	enzymatic	ADJ
ijpds-2904	70	26	reactions	reaction	NOUN
ijpds-2904	70	27	.	.	PUNCT
ijpds-2904	71	1	because	because	SCONJ
ijpds-2904	71	2	of	of	ADP
ijpds-2904	71	3	its	its	PRON
ijpds-2904	71	4	important	important	ADJ
ijpds-2904	71	5	biological	biological	ADJ
ijpds-2904	71	6	role	role	NOUN
ijpds-2904	71	7	,	,	PUNCT
ijpds-2904	71	8	ctr1	ctr1	PROPN
ijpds-2904	71	9	is	be	AUX
ijpds-2904	71	10	almost	almost	ADV
ijpds-2904	71	11	ubiquitously	ubiquitously	ADV
ijpds-2904	71	12	expressed	express	VERB
ijpds-2904	71	13	and	and	CCONJ
ijpds-2904	71	14	perhaps	perhaps	ADV
ijpds-2904	71	15	may	may	AUX
ijpds-2904	71	16	not	not	PART
ijpds-2904	71	17	be	be	AUX
ijpds-2904	71	18	the	the	DET
ijpds-2904	71	19	decisive	decisive	ADJ
ijpds-2904	71	20	transporter	transporter	NOUN
ijpds-2904	71	21	for	for	ADP
ijpds-2904	71	22	specific	specific	ADJ
ijpds-2904	71	23	cisplatin	cisplatin	NOUN
ijpds-2904	71	24	toxicities	toxicity	NOUN
ijpds-2904	71	25	.	.	PUNCT
ijpds-2904	72	1	since	since	SCONJ
ijpds-2904	72	2	several	several	ADJ
ijpds-2904	72	3	cell	cell	NOUN
ijpds-2904	72	4	lines	line	NOUN
ijpds-2904	72	5	from	from	ADP
ijpds-2904	72	6	human	human	ADJ
ijpds-2904	72	7	tumor	tumor	NOUN
ijpds-2904	72	8	samples	sample	NOUN
ijpds-2904	72	9	express	express	VERB
ijpds-2904	72	10	ctr1mrna	ctr1mrna	PROPN
ijpds-2904	72	11	,	,	PUNCT
ijpds-2904	72	12	this	this	DET
ijpds-2904	72	13	transporter	transporter	NOUN
ijpds-2904	72	14	could	could	AUX
ijpds-2904	72	15	represent	represent	VERB
ijpds-2904	72	16	the	the	DET
ijpds-2904	72	17	uptake	uptake	ADJ
ijpds-2904	72	18	route	route	NOUN
ijpds-2904	72	19	of	of	ADP
ijpds-2904	72	20	cisplatin	cisplatin	NOUN
ijpds-2904	72	21	in	in	ADP
ijpds-2904	72	22	cancer	cancer	NOUN
ijpds-2904	72	23	cells	cell	NOUN
ijpds-2904	72	24	.	.	PUNCT
ijpds-2904	73	1	indeed	indeed	ADV
ijpds-2904	73	2	,	,	PUNCT
ijpds-2904	73	3	high	high	ADJ
ijpds-2904	73	4	sakshi	sakshi	PROPN
ijpds-2904	73	5	and	and	CCONJ
ijpds-2904	73	6	singh	singh	PROPN
ijpds-2904	73	7	cisplatin	cisplatin	NOUN
ijpds-2904	73	8	induced	induce	VERB
ijpds-2904	73	9	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	73	10	vol	vol	NOUN
ijpds-2904	73	11	1	1	NUM
ijpds-2904	73	12	|	|	NOUN
ijpds-2904	73	13	issue	issue	VERB
ijpds-2904	73	14	1	1	NUM
ijpds-2904	73	15	|	|	ADV
ijpds-2904	73	16	apr	apr	ADV
ijpds-2904	73	17	–	–	PUNCT
ijpds-2904	73	18	jun	jun	PROPN
ijpds-2904	73	19	2022	2022	NUM
ijpds-2904	73	20	indian	indian	PROPN
ijpds-2904	73	21	j	j	PROPN
ijpds-2904	73	22	pharm	pharm	PROPN
ijpds-2904	73	23	drug	drug	PROPN
ijpds-2904	73	24	studies	study	NOUN
ijpds-2904	73	25	|	|	ADV
ijpds-2904	73	26	7	7	NUM
ijpds-2904	73	27	expression	expression	NOUN
ijpds-2904	73	28	levels	level	NOUN
ijpds-2904	73	29	of	of	ADP
ijpds-2904	73	30	ctr1	ctr1	PROPN
ijpds-2904	73	31	have	have	AUX
ijpds-2904	73	32	been	be	AUX
ijpds-2904	73	33	associated	associate	VERB
ijpds-2904	73	34	with	with	ADP
ijpds-2904	73	35	cisplatin	cisplatin	NOUN
ijpds-2904	73	36	therapeutic	therapeutic	ADJ
ijpds-2904	73	37	success	success	NOUN
ijpds-2904	73	38	whereas	whereas	SCONJ
ijpds-2904	73	39	ctr1	ctr1	PROPN
ijpds-2904	73	40	mutations	mutation	NOUN
ijpds-2904	73	41	are	be	AUX
ijpds-2904	73	42	associated	associate	VERB
ijpds-2904	73	43	with	with	ADP
ijpds-2904	73	44	cisplatin	cisplatin	NOUN
ijpds-2904	73	45	resistance	resistance	NOUN
ijpds-2904	73	46	.	.	PUNCT
ijpds-2904	74	1	ctr1	ctr1	PROPN
ijpds-2904	74	2	has	have	AUX
ijpds-2904	74	3	been	be	AUX
ijpds-2904	74	4	also	also	ADV
ijpds-2904	74	5	associated	associate	VERB
ijpds-2904	74	6	with	with	ADP
ijpds-2904	74	7	the	the	DET
ijpds-2904	74	8	cellular	cellular	ADJ
ijpds-2904	74	9	transport	transport	NOUN
ijpds-2904	74	10	of	of	ADP
ijpds-2904	74	11	carboplatin	carboplatin	NOUN
ijpds-2904	74	12	and	and	CCONJ
ijpds-2904	74	13	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	75	1	[	[	X
ijpds-2904	75	2	28	28	NUM
ijpds-2904	75	3	]	]	PUNCT
ijpds-2904	75	4	.	.	PUNCT
ijpds-2904	76	1	copper	copper	NOUN
ijpds-2904	76	2	transporter	transporter	NOUN
ijpds-2904	76	3	2	2	NUM
ijpds-2904	76	4	(	(	PUNCT
ijpds-2904	76	5	ctr2	ctr2	PROPN
ijpds-2904	76	6	)	)	PUNCT
ijpds-2904	76	7	copper	copper	NOUN
ijpds-2904	76	8	transporter	transporter	NOUN
ijpds-2904	76	9	2	2	NUM
ijpds-2904	76	10	(	(	PUNCT
ijpds-2904	76	11	ctr2	ctr2	PROPN
ijpds-2904	76	12	,	,	PUNCT
ijpds-2904	76	13	slc31a2	slc31a2	ADJ
ijpds-2904	76	14	)	)	PUNCT
ijpds-2904	76	15	is	be	AUX
ijpds-2904	76	16	a	a	DET
ijpds-2904	76	17	copper	copper	NOUN
ijpds-2904	76	18	transport	transport	NOUN
ijpds-2904	76	19	protein	protein	NOUN
ijpds-2904	76	20	with	with	ADP
ijpds-2904	76	21	substantia	substantia	NOUN
ijpds-2904	76	22	structural	structural	ADJ
ijpds-2904	76	23	homology	homology	NOUN
ijpds-2904	76	24	to	to	ADP
ijpds-2904	76	25	ctr1	ctr1	PROPN
ijpds-2904	76	26	.	.	PUNCT
ijpds-2904	77	1	ctr2	ctr2	PROPN
ijpds-2904	77	2	is	be	AUX
ijpds-2904	77	3	mainly	mainly	ADV
ijpds-2904	77	4	expressed	express	VERB
ijpds-2904	77	5	in	in	ADP
ijpds-2904	77	6	late	late	ADJ
ijpds-2904	77	7	endosomes	endosome	NOUN
ijpds-2904	77	8	and	and	CCONJ
ijpds-2904	77	9	lysosomes	lysosome	NOUN
ijpds-2904	77	10	,	,	PUNCT
ijpds-2904	77	11	where	where	SCONJ
ijpds-2904	77	12	it	it	PRON
ijpds-2904	77	13	probably	probably	ADV
ijpds-2904	77	14	mediates	mediate	VERB
ijpds-2904	77	15	the	the	DET
ijpds-2904	77	16	efflux	efflux	NOUN
ijpds-2904	77	17	of	of	ADP
ijpds-2904	77	18	copper	copper	NOUN
ijpds-2904	77	19	under	under	ADP
ijpds-2904	77	20	conditions	condition	NOUN
ijpds-2904	77	21	of	of	ADP
ijpds-2904	77	22	low	low	ADJ
ijpds-2904	77	23	environmental	environmental	ADJ
ijpds-2904	77	24	copper	copper	NOUN
ijpds-2904	77	25	concentration	concentration	NOUN
ijpds-2904	77	26	[	[	X
ijpds-2904	77	27	12	12	NUM
ijpds-2904	77	28	]	]	PUNCT
ijpds-2904	77	29	.	.	PUNCT
ijpds-2904	78	1	a	a	DET
ijpds-2904	78	2	similar	similar	ADJ
ijpds-2904	78	3	function	function	NOUN
ijpds-2904	78	4	of	of	ADP
ijpds-2904	78	5	ctr2	ctr2	PROPN
ijpds-2904	78	6	was	be	AUX
ijpds-2904	78	7	proposed	propose	VERB
ijpds-2904	78	8	for	for	ADP
ijpds-2904	78	9	cisplatin	cisplatin	NOUN
ijpds-2904	78	10	.	.	PUNCT
ijpds-2904	79	1	studies	study	NOUN
ijpds-2904	79	2	in	in	ADP
ijpds-2904	79	3	ctr2	ctr2	PROPN
ijpds-2904	79	4	-	-	PUNCT
ijpds-2904	79	5	deficientmice	deficientmice	NOUN
ijpds-2904	79	6	suggested	suggest	VERB
ijpds-2904	79	7	that	that	SCONJ
ijpds-2904	79	8	ctr2	ctr2	PROPN
ijpds-2904	79	9	functions	function	NOUN
ijpds-2904	79	10	as	as	ADP
ijpds-2904	79	11	an	an	DET
ijpds-2904	79	12	indirect	indirect	ADJ
ijpds-2904	79	13	regulator	regulator	NOUN
ijpds-2904	79	14	of	of	ADP
ijpds-2904	79	15	cu+uptake	cu+uptake	NOUN
ijpds-2904	79	16	and	and	CCONJ
ijpds-2904	79	17	intracellular	intracellular	ADJ
ijpds-2904	79	18	flux	flux	NOUN
ijpds-2904	79	19	by	by	ADP
ijpds-2904	79	20	stabilizing	stabilize	VERB
ijpds-2904	79	21	the	the	DET
ijpds-2904	79	22	biosynthesis	biosynthesis	NOUN
ijpds-2904	79	23	of	of	ADP
ijpds-2904	79	24	cleaved	cleaved	ADJ
ijpds-2904	79	25	ctr1	ctr1	NOUN
ijpds-2904	79	26	.	.	PUNCT
ijpds-2904	80	1	the	the	DET
ijpds-2904	80	2	cleaved	cleaved	ADJ
ijpds-2904	80	3	ctr1	ctr1	NOUN
ijpds-2904	80	4	is	be	AUX
ijpds-2904	80	5	a	a	DET
ijpds-2904	80	6	transporter	transporter	NOUN
ijpds-2904	80	7	form	form	NOUN
ijpds-2904	80	8	which	which	PRON
ijpds-2904	80	9	lacks	lack	VERB
ijpds-2904	80	10	metal	metal	NOUN
ijpds-2904	80	11	binding	bind	VERB
ijpds-2904	80	12	methionineand	methionineand	NOUN
ijpds-2904	80	13	histidine	histidine	NOUN
ijpds-2904	80	14	-	-	PUNCT
ijpds-2904	80	15	rich	rich	ADJ
ijpds-2904	80	16	motifs	motif	NOUN
ijpds-2904	80	17	and	and	CCONJ
ijpds-2904	80	18	of	of	ADP
ijpds-2904	80	19	consequence	consequence	NOUN
ijpds-2904	80	20	has	have	AUX
ijpds-2904	80	21	decreased	decrease	VERB
ijpds-2904	80	22	cu+	cu+	NOUN
ijpds-2904	80	23	and	and	CCONJ
ijpds-2904	80	24	also	also	ADV
ijpds-2904	80	25	cisplatin	cisplatin	NOUN
ijpds-2904	80	26	uptake	uptake	ADJ
ijpds-2904	80	27	function	function	NOUN
ijpds-2904	80	28	[	[	X
ijpds-2904	80	29	29	29	NUM
ijpds-2904	80	30	]	]	PUNCT
ijpds-2904	80	31	.	.	PUNCT
ijpds-2904	81	1	therefore	therefore	ADV
ijpds-2904	81	2	,	,	PUNCT
ijpds-2904	81	3	high	high	ADJ
ijpds-2904	81	4	expression	expression	NOUN
ijpds-2904	81	5	of	of	ADP
ijpds-2904	81	6	ctr2	ctr2	PROPN
ijpds-2904	81	7	seems	seem	VERB
ijpds-2904	81	8	to	to	PART
ijpds-2904	81	9	be	be	AUX
ijpds-2904	81	10	associated	associate	VERB
ijpds-2904	81	11	with	with	ADP
ijpds-2904	81	12	resistance	resistance	NOUN
ijpds-2904	81	13	to	to	ADP
ijpds-2904	81	14	the	the	DET
ijpds-2904	81	15	cytotoxic	cytotoxic	ADJ
ijpds-2904	81	16	effect	effect	NOUN
ijpds-2904	81	17	of	of	ADP
ijpds-2904	81	18	cisplatin	cisplatin	NOUN
ijpds-2904	81	19	and	and	CCONJ
ijpds-2904	81	20	knockdown	knockdown	NOUN
ijpds-2904	81	21	of	of	ADP
ijpds-2904	81	22	ctr2	ctr2	PROPN
ijpds-2904	81	23	was	be	AUX
ijpds-2904	81	24	associated	associate	VERB
ijpds-2904	81	25	with	with	ADP
ijpds-2904	81	26	an	an	DET
ijpds-2904	81	27	increased	increase	VERB
ijpds-2904	81	28	cisplatin	cisplatin	NOUN
ijpds-2904	81	29	accumulation	accumulation	NOUN
ijpds-2904	81	30	and	and	CCONJ
ijpds-2904	81	31	cytotoxicity	cytotoxicity	NOUN
ijpds-2904	81	32	[	[	X
ijpds-2904	81	33	30	30	NUM
ijpds-2904	81	34	]	]	PUNCT
ijpds-2904	81	35	.	.	PUNCT
ijpds-2904	82	1	copper	copper	NOUN
ijpds-2904	82	2	-	-	PUNCT
ijpds-2904	82	3	transporting	transport	VERB
ijpds-2904	82	4	(	(	PUNCT
ijpds-2904	82	5	atp7a	atp7a	NUM
ijpds-2904	82	6	and	and	CCONJ
ijpds-2904	82	7	atp7b	atp7b	PROPN
ijpds-2904	82	8	)	)	PUNCT
ijpds-2904	82	9	the	the	DET
ijpds-2904	82	10	p	p	ADJ
ijpds-2904	82	11	-	-	PUNCT
ijpds-2904	82	12	type	type	NOUN
ijpds-2904	82	13	copper	copper	NOUN
ijpds-2904	82	14	-	-	PUNCT
ijpds-2904	82	15	transporting	transport	VERB
ijpds-2904	82	16	atpases	atpase	NOUN
ijpds-2904	82	17	atp7a	atp7a	PUNCT
ijpds-2904	82	18	and	and	CCONJ
ijpds-2904	82	19	atp7b	atp7b	PROPN
ijpds-2904	82	20	are	be	AUX
ijpds-2904	82	21	also	also	ADV
ijpds-2904	82	22	involved	involve	VERB
ijpds-2904	82	23	in	in	ADP
ijpds-2904	82	24	cellular	cellular	ADJ
ijpds-2904	82	25	cisplatin	cisplatin	NOUN
ijpds-2904	82	26	handling	handling	NOUN
ijpds-2904	82	27	[	[	X
ijpds-2904	82	28	31	31	NUM
ijpds-2904	82	29	]	]	PUNCT
ijpds-2904	82	30	.	.	PUNCT
ijpds-2904	83	1	these	these	DET
ijpds-2904	83	2	transporters	transporter	NOUN
ijpds-2904	83	3	play	play	VERB
ijpds-2904	83	4	an	an	DET
ijpds-2904	83	5	important	important	ADJ
ijpds-2904	83	6	role	role	NOUN
ijpds-2904	83	7	in	in	ADP
ijpds-2904	83	8	regulating	regulate	VERB
ijpds-2904	83	9	the	the	DET
ijpds-2904	83	10	cellular	cellular	ADJ
ijpds-2904	83	11	copper	copper	NOUN
ijpds-2904	83	12	levels	level	NOUN
ijpds-2904	83	13	,	,	PUNCT
ijpds-2904	83	14	because	because	SCONJ
ijpds-2904	83	15	too	too	ADV
ijpds-2904	83	16	high	high	ADJ
ijpds-2904	83	17	intracellular	intracellular	ADJ
ijpds-2904	83	18	copper	copper	NOUN
ijpds-2904	83	19	concentrations	concentration	NOUN
ijpds-2904	83	20	are	be	AUX
ijpds-2904	83	21	toxic	toxic	ADJ
ijpds-2904	83	22	for	for	ADP
ijpds-2904	83	23	the	the	DET
ijpds-2904	83	24	cell	cell	NOUN
ijpds-2904	83	25	[	[	X
ijpds-2904	83	26	32	32	NUM
ijpds-2904	83	27	]	]	PUNCT
ijpds-2904	83	28	.	.	PUNCT
ijpds-2904	84	1	inactivation	inactivation	NOUN
ijpds-2904	84	2	of	of	ADP
ijpds-2904	84	3	these	these	DET
ijpds-2904	84	4	transporters	transporter	NOUN
ijpds-2904	84	5	,	,	PUNCT
ijpds-2904	84	6	as	as	ADP
ijpds-2904	84	7	present	present	ADJ
ijpds-2904	84	8	for	for	ADP
ijpds-2904	84	9	example	example	NOUN
ijpds-2904	84	10	in	in	ADP
ijpds-2904	84	11	menkes	menke	NOUN
ijpds-2904	84	12	’	'	PUNCT
ijpds-2904	84	13	disease	disease	NOUN
ijpds-2904	84	14	(	(	PUNCT
ijpds-2904	84	15	inactivation	inactivation	NOUN
ijpds-2904	84	16	of	of	ADP
ijpds-2904	84	17	atp7a	atp7a	NUM
ijpds-2904	84	18	)	)	PUNCT
ijpds-2904	84	19	and	and	CCONJ
ijpds-2904	84	20	in	in	ADP
ijpds-2904	84	21	wilson	wilson	PROPN
ijpds-2904	84	22	’s	’s	PART
ijpds-2904	84	23	disease	disease	NOUN
ijpds-2904	84	24	(	(	PUNCT
ijpds-2904	84	25	inactivation	inactivation	NOUN
ijpds-2904	84	26	of	of	ADP
ijpds-2904	84	27	atp7b	atp7b	PROPN
ijpds-2904	84	28	)	)	PUNCT
ijpds-2904	84	29	,	,	PUNCT
ijpds-2904	84	30	is	be	AUX
ijpds-2904	84	31	associated	associate	VERB
ijpds-2904	84	32	with	with	ADP
ijpds-2904	84	33	copper	copper	NOUN
ijpds-2904	84	34	deficiency	deficiency	NOUN
ijpds-2904	84	35	because	because	SCONJ
ijpds-2904	84	36	of	of	ADP
ijpds-2904	84	37	impaired	impaired	ADJ
ijpds-2904	84	38	copper	copper	NOUN
ijpds-2904	84	39	efflux	efflux	NOUN
ijpds-2904	84	40	from	from	ADP
ijpds-2904	84	41	enterocytes	enterocyte	NOUN
ijpds-2904	84	42	into	into	ADP
ijpds-2904	84	43	the	the	DET
ijpds-2904	84	44	blood	blood	NOUN
ijpds-2904	84	45	or	or	CCONJ
ijpds-2904	84	46	massive	massive	ADJ
ijpds-2904	84	47	cellular	cellular	ADJ
ijpds-2904	84	48	copper	copper	NOUN
ijpds-2904	84	49	overload	overload	NOUN
ijpds-2904	84	50	,	,	PUNCT
ijpds-2904	84	51	respectively	respectively	ADV
ijpds-2904	84	52	[	[	X
ijpds-2904	84	53	26	26	NUM
ijpds-2904	84	54	]	]	PUNCT
ijpds-2904	84	55	.	.	PUNCT
ijpds-2904	85	1	while	while	SCONJ
ijpds-2904	85	2	atp7a	atp7a	PROPN
ijpds-2904	85	3	is	be	AUX
ijpds-2904	85	4	mainly	mainly	ADV
ijpds-2904	85	5	expressed	express	VERB
ijpds-2904	85	6	in	in	ADP
ijpds-2904	85	7	intestine	intestine	NOUN
ijpds-2904	85	8	,	,	PUNCT
ijpds-2904	85	9	choroid	choroid	NOUN
ijpds-2904	85	10	plexus	plexus	NOUN
ijpds-2904	85	11	,	,	PUNCT
ijpds-2904	85	12	vascular	vascular	ADJ
ijpds-2904	85	13	smooth	smooth	ADJ
ijpds-2904	85	14	muscle	muscle	NOUN
ijpds-2904	85	15	and	and	CCONJ
ijpds-2904	85	16	endothelial	endothelial	NOUN
ijpds-2904	85	17	cells	cell	NOUN
ijpds-2904	85	18	,	,	PUNCT
ijpds-2904	85	19	as	as	ADV
ijpds-2904	85	20	well	well	ADV
ijpds-2904	85	21	as	as	ADP
ijpds-2904	85	22	in	in	ADP
ijpds-2904	85	23	cerebrovascular	cerebrovascular	ADJ
ijpds-2904	85	24	endothelial	endothelial	ADJ
ijpds-2904	85	25	cells	cell	NOUN
ijpds-2904	85	26	,	,	PUNCT
ijpds-2904	85	27	atp7b	atp7b	PRON
ijpds-2904	85	28	is	be	AUX
ijpds-2904	85	29	principally	principally	ADV
ijpds-2904	85	30	expressed	express	VERB
ijpds-2904	85	31	in	in	ADP
ijpds-2904	85	32	the	the	DET
ijpds-2904	85	33	liver	liver	NOUN
ijpds-2904	85	34	and	and	CCONJ
ijpds-2904	85	35	the	the	DET
ijpds-2904	85	36	brain	brain	NOUN
ijpds-2904	86	1	[	[	X
ijpds-2904	86	2	33	33	NUM
ijpds-2904	86	3	]	]	PUNCT
ijpds-2904	86	4	.	.	PUNCT
ijpds-2904	87	1	regarding	regard	VERB
ijpds-2904	87	2	the	the	DET
ijpds-2904	87	3	transport	transport	NOUN
ijpds-2904	87	4	of	of	ADP
ijpds-2904	87	5	cisplatin	cisplatin	NOUN
ijpds-2904	87	6	,	,	PUNCT
ijpds-2904	87	7	atp7a	atp7a	PUNCT
ijpds-2904	87	8	and	and	CCONJ
ijpds-2904	87	9	atp7b	atp7b	PRON
ijpds-2904	87	10	mediate	mediate	VERB
ijpds-2904	87	11	its	its	PRON
ijpds-2904	87	12	efflux	efflux	NOUN
ijpds-2904	87	13	from	from	ADP
ijpds-2904	87	14	the	the	DET
ijpds-2904	87	15	cell	cell	NOUN
ijpds-2904	87	16	or	or	CCONJ
ijpds-2904	87	17	its	its	PRON
ijpds-2904	87	18	distribution	distribution	NOUN
ijpds-2904	87	19	to	to	ADP
ijpds-2904	87	20	specific	specific	ADJ
ijpds-2904	87	21	sub	sub	ADJ
ijpds-2904	87	22	-	-	ADJ
ijpds-2904	87	23	cellular	cellular	ADJ
ijpds-2904	87	24	compartments	compartment	NOUN
ijpds-2904	87	25	[	[	X
ijpds-2904	87	26	34	34	NUM
ijpds-2904	87	27	]	]	PUNCT
ijpds-2904	87	28	.	.	PUNCT
ijpds-2904	88	1	for	for	ADP
ijpds-2904	88	2	this	this	DET
ijpds-2904	88	3	reason	reason	NOUN
ijpds-2904	88	4	,	,	PUNCT
ijpds-2904	88	5	the	the	DET
ijpds-2904	88	6	expression	expression	NOUN
ijpds-2904	88	7	of	of	ADP
ijpds-2904	88	8	these	these	DET
ijpds-2904	88	9	transporters	transporter	NOUN
ijpds-2904	88	10	is	be	AUX
ijpds-2904	88	11	correlated	correlate	VERB
ijpds-2904	88	12	with	with	ADP
ijpds-2904	88	13	cisplatin	cisplatin	NOUN
ijpds-2904	88	14	cellular	cellular	ADJ
ijpds-2904	88	15	sensitivity	sensitivity	NOUN
ijpds-2904	88	16	and	and	CCONJ
ijpds-2904	88	17	resistance	resistance	NOUN
ijpds-2904	89	1	atp7b	atp7b	PRON
ijpds-2904	89	2	is	be	AUX
ijpds-2904	89	3	stronger	strong	ADJ
ijpds-2904	89	4	associated	associate	VERB
ijpds-2904	89	5	with	with	ADP
ijpds-2904	89	6	the	the	DET
ijpds-2904	89	7	acquisition	acquisition	NOUN
ijpds-2904	89	8	of	of	ADP
ijpds-2904	89	9	resistance	resistance	NOUN
ijpds-2904	89	10	than	than	ADP
ijpds-2904	89	11	ctr1	ctr1	PROPN
ijpds-2904	89	12	or	or	CCONJ
ijpds-2904	89	13	atp7a	atp7a	PROPN
ijpds-2904	89	14	.	.	PUNCT
ijpds-2904	90	1	besides	besides	SCONJ
ijpds-2904	90	2	cisplatin	cisplatin	NOUN
ijpds-2904	90	3	,	,	PUNCT
ijpds-2904	90	4	atp7a	atp7a	PUNCT
ijpds-2904	90	5	and	and	CCONJ
ijpds-2904	90	6	b	b	NOUN
ijpds-2904	90	7	transporters	transporter	NOUN
ijpds-2904	90	8	also	also	ADV
ijpds-2904	90	9	interact	interact	VERB
ijpds-2904	90	10	with	with	ADP
ijpds-2904	90	11	carboplatin	carboplatin	NOUN
ijpds-2904	90	12	and	and	CCONJ
ijpds-2904	90	13	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	91	1	[	[	X
ijpds-2904	91	2	35	35	NUM
ijpds-2904	91	3	]	]	PUNCT
ijpds-2904	91	4	.	.	PUNCT
ijpds-2904	92	1	even	even	ADV
ijpds-2904	92	2	though	though	SCONJ
ijpds-2904	92	3	the	the	DET
ijpds-2904	92	4	effects	effect	NOUN
ijpds-2904	92	5	of	of	ADP
ijpds-2904	92	6	atp7a	atp7a	NUM
ijpds-2904	92	7	and	and	CCONJ
ijpds-2904	92	8	b	b	X
ijpds-2904	92	9	transporters	transporter	NOUN
ijpds-2904	92	10	on	on	ADP
ijpds-2904	92	11	cisplatin	cisplatin	NOUN
ijpds-2904	92	12	cellular	cellular	ADJ
ijpds-2904	92	13	distribution	distribution	NOUN
ijpds-2904	92	14	are	be	AUX
ijpds-2904	92	15	very	very	ADV
ijpds-2904	92	16	similar	similar	ADJ
ijpds-2904	92	17	to	to	ADP
ijpds-2904	92	18	those	those	PRON
ijpds-2904	92	19	observed	observe	VERB
ijpds-2904	92	20	for	for	ADP
ijpds-2904	92	21	copper	copper	NOUN
ijpds-2904	92	22	,	,	PUNCT
ijpds-2904	92	23	platinum	platinum	NOUN
ijpds-2904	92	24	drugs	drug	NOUN
ijpds-2904	92	25	are	be	AUX
ijpds-2904	92	26	not	not	PART
ijpds-2904	92	27	readily	readily	ADV
ijpds-2904	92	28	exported	export	VERB
ijpds-2904	92	29	after	after	ADP
ijpds-2904	92	30	vesicular	vesicular	ADJ
ijpds-2904	92	31	sequestration	sequestration	NOUN
ijpds-2904	92	32	[	[	X
ijpds-2904	92	33	35	35	NUM
ijpds-2904	92	34	]	]	PUNCT
ijpds-2904	92	35	.	.	PUNCT
ijpds-2904	93	1	interestingly	interestingly	ADV
ijpds-2904	93	2	,	,	PUNCT
ijpds-2904	93	3	copper	copper	NOUN
ijpds-2904	93	4	transport	transport	NOUN
ijpds-2904	93	5	systems	system	NOUN
ijpds-2904	93	6	are	be	AUX
ijpds-2904	93	7	expressed	express	VERB
ijpds-2904	93	8	and	and	CCONJ
ijpds-2904	93	9	active	active	ADJ
ijpds-2904	93	10	in	in	ADP
ijpds-2904	93	11	drg	drg	PROPN
ijpds-2904	93	12	,	,	PUNCT
ijpds-2904	93	13	which	which	PRON
ijpds-2904	93	14	are	be	AUX
ijpds-2904	93	15	sensitive	sensitive	ADJ
ijpds-2904	93	16	to	to	ADP
ijpds-2904	93	17	toxicity	toxicity	NOUN
ijpds-2904	93	18	from	from	ADP
ijpds-2904	93	19	platinum	platinum	NOUN
ijpds-2904	93	20	derivatives	derivative	NOUN
ijpds-2904	93	21	.	.	PUNCT
ijpds-2904	94	1	here	here	ADV
ijpds-2904	94	2	,	,	PUNCT
ijpds-2904	94	3	ctr1	ctr1	PROPN
ijpds-2904	94	4	is	be	AUX
ijpds-2904	94	5	expressed	express	VERB
ijpds-2904	94	6	in	in	ADP
ijpds-2904	94	7	large	large	ADJ
ijpds-2904	94	8	-	-	PUNCT
ijpds-2904	94	9	sized	sized	ADJ
ijpds-2904	94	10	neurons	neuron	NOUN
ijpds-2904	94	11	and	and	CCONJ
ijpds-2904	94	12	atp7a	atp7a	PUNCT
ijpds-2904	94	13	in	in	ADP
ijpds-2904	94	14	small	small	ADJ
ijpds-2904	94	15	drg	drg	NOUN
ijpds-2904	94	16	neurons	neuron	NOUN
ijpds-2904	94	17	,	,	PUNCT
ijpds-2904	94	18	suggesting	suggest	VERB
ijpds-2904	94	19	that	that	SCONJ
ijpds-2904	94	20	large	large	ADJ
ijpds-2904	94	21	neurons	neuron	NOUN
ijpds-2904	94	22	are	be	AUX
ijpds-2904	94	23	especially	especially	ADV
ijpds-2904	94	24	sensitive	sensitive	ADJ
ijpds-2904	94	25	and	and	CCONJ
ijpds-2904	94	26	small	small	ADJ
ijpds-2904	94	27	neurons	neuron	NOUN
ijpds-2904	94	28	are	be	AUX
ijpds-2904	94	29	protected	protect	VERB
ijpds-2904	94	30	from	from	ADP
ijpds-2904	94	31	toxic	toxic	ADJ
ijpds-2904	94	32	effects	effect	NOUN
ijpds-2904	94	33	of	of	ADP
ijpds-2904	94	34	platinum	platinum	NOUN
ijpds-2904	94	35	derivatives	derivative	NOUN
ijpds-2904	94	36	[	[	X
ijpds-2904	94	37	36	36	NUM
ijpds-2904	94	38	]	]	PUNCT
ijpds-2904	94	39	.	.	PUNCT
ijpds-2904	95	1	organic	organic	ADJ
ijpds-2904	95	2	cation	cation	NOUN
ijpds-2904	95	3	transporters	transporter	NOUN
ijpds-2904	95	4	(	(	PUNCT
ijpds-2904	95	5	oct1	oct1	NOUN
ijpds-2904	95	6	-	-	PUNCT
ijpds-2904	95	7	3	3	NUM
ijpds-2904	95	8	,	,	PUNCT
ijpds-2904	95	9	slc22a1	slc22a1	NOUN
ijpds-2904	95	10	-	-	PUNCT
ijpds-2904	95	11	3	3	NUM
ijpds-2904	95	12	)	)	PUNCT
ijpds-2904	95	13	a	a	DET
ijpds-2904	95	14	specific	specific	ADJ
ijpds-2904	95	15	interaction	interaction	NOUN
ijpds-2904	95	16	of	of	ADP
ijpds-2904	95	17	cisplatin	cisplatin	NOUN
ijpds-2904	95	18	with	with	ADP
ijpds-2904	95	19	octs	oct	NOUN
ijpds-2904	95	20	has	have	AUX
ijpds-2904	95	21	also	also	ADV
ijpds-2904	95	22	been	be	AUX
ijpds-2904	95	23	demonstrated	demonstrate	VERB
ijpds-2904	95	24	.	.	PUNCT
ijpds-2904	96	1	since	since	SCONJ
ijpds-2904	96	2	octs	oct	NOUN
ijpds-2904	96	3	have	have	VERB
ijpds-2904	96	4	a	a	DET
ijpds-2904	96	5	specific	specific	ADJ
ijpds-2904	96	6	organ	organ	NOUN
ijpds-2904	96	7	distribution	distribution	NOUN
ijpds-2904	96	8	,	,	PUNCT
ijpds-2904	96	9	with	with	ADP
ijpds-2904	96	10	high	high	ADJ
ijpds-2904	96	11	renal	renal	ADJ
ijpds-2904	96	12	expression	expression	NOUN
ijpds-2904	96	13	,	,	PUNCT
ijpds-2904	96	14	the	the	DET
ijpds-2904	96	15	cisplatin	cisplatin	NOUN
ijpds-2904	96	16	-	-	PUNCT
ijpds-2904	96	17	oct	oct	NOUN
ijpds-2904	96	18	interaction	interaction	NOUN
ijpds-2904	96	19	is	be	AUX
ijpds-2904	96	20	of	of	ADP
ijpds-2904	96	21	pecial	pecial	ADJ
ijpds-2904	96	22	interest	interest	NOUN
ijpds-2904	96	23	to	to	PART
ijpds-2904	96	24	explain	explain	VERB
ijpds-2904	96	25	selective	selective	ADJ
ijpds-2904	96	26	organ	organ	NOUN
ijpds-2904	96	27	toxicity	toxicity	NOUN
ijpds-2904	96	28	of	of	ADP
ijpds-2904	96	29	cisplatin	cisplatin	NOUN
ijpds-2904	96	30	[	[	X
ijpds-2904	96	31	26	26	NUM
ijpds-2904	96	32	]	]	PUNCT
ijpds-2904	96	33	.	.	PUNCT
ijpds-2904	97	1	octs	oct	NOUN
ijpds-2904	97	2	are	be	AUX
ijpds-2904	97	3	highly	highly	ADV
ijpds-2904	97	4	expressed	express	VERB
ijpds-2904	97	5	in	in	ADP
ijpds-2904	97	6	excretory	excretory	NOUN
ijpds-2904	97	7	organs	organ	NOUN
ijpds-2904	97	8	such	such	ADJ
ijpds-2904	97	9	as	as	ADP
ijpds-2904	97	10	the	the	DET
ijpds-2904	97	11	liver	liver	NOUN
ijpds-2904	97	12	and	and	CCONJ
ijpds-2904	97	13	the	the	DET
ijpds-2904	97	14	kidneys	kidney	NOUN
ijpds-2904	97	15	,	,	PUNCT
ijpds-2904	97	16	where	where	SCONJ
ijpds-2904	97	17	they	they	PRON
ijpds-2904	97	18	mediate	mediate	VERB
ijpds-2904	97	19	the	the	DET
ijpds-2904	97	20	electrogenic	electrogenic	ADJ
ijpds-2904	97	21	uptake	uptake	NOUN
ijpds-2904	97	22	of	of	ADP
ijpds-2904	97	23	heir	heir	NOUN
ijpds-2904	97	24	substrates	substrate	NOUN
ijpds-2904	97	25	in	in	ADP
ijpds-2904	97	26	hepatocytes	hepatocyte	NOUN
ijpds-2904	97	27	and	and	CCONJ
ijpds-2904	97	28	proximal	proximal	ADJ
ijpds-2904	97	29	tubule	tubule	NOUN
ijpds-2904	97	30	cells	cell	NOUN
ijpds-2904	97	31	.	.	PUNCT
ijpds-2904	98	1	octs	oct	NOUN
ijpds-2904	98	2	are	be	AUX
ijpds-2904	98	3	defined	define	VERB
ijpds-2904	98	4	as	as	ADP
ijpds-2904	98	5	polyspecific	polyspecific	ADJ
ijpds-2904	98	6	transporters	transporter	NOUN
ijpds-2904	98	7	,	,	PUNCT
ijpds-2904	98	8	because	because	SCONJ
ijpds-2904	98	9	they	they	PRON
ijpds-2904	98	10	can	can	AUX
ijpds-2904	98	11	transport	transport	VERB
ijpds-2904	98	12	several	several	ADJ
ijpds-2904	98	13	unrelated	unrelated	ADJ
ijpds-2904	98	14	substances	substance	NOUN
ijpds-2904	98	15	.	.	PUNCT
ijpds-2904	99	1	the	the	DET
ijpds-2904	99	2	driving	drive	VERB
ijpds-2904	99	3	force	force	NOUN
ijpds-2904	99	4	for	for	ADP
ijpds-2904	99	5	the	the	DET
ijpds-2904	99	6	cellular	cellular	ADJ
ijpds-2904	99	7	transport	transport	NOUN
ijpds-2904	99	8	by	by	ADP
ijpds-2904	99	9	octs	oct	NOUN
ijpds-2904	99	10	is	be	AUX
ijpds-2904	99	11	the	the	DET
ijpds-2904	99	12	electrochemical	electrochemical	ADJ
ijpds-2904	99	13	gradient	gradient	NOUN
ijpds-2904	99	14	of	of	ADP
ijpds-2904	99	15	the	the	DET
ijpds-2904	99	16	substrate	substrate	NOUN
ijpds-2904	99	17	[	[	X
ijpds-2904	99	18	37	37	NUM
ijpds-2904	99	19	]	]	PUNCT
ijpds-2904	99	20	.	.	PUNCT
ijpds-2904	100	1	in	in	ADP
ijpds-2904	100	2	excretory	excretory	NOUN
ijpds-2904	100	3	organs	organ	NOUN
ijpds-2904	100	4	,	,	PUNCT
ijpds-2904	100	5	octs	oct	VERB
ijpds-2904	100	6	mediate	mediate	VERB
ijpds-2904	100	7	the	the	DET
ijpds-2904	100	8	first	first	ADJ
ijpds-2904	100	9	step	step	NOUN
ijpds-2904	100	10	of	of	ADP
ijpds-2904	100	11	secretion	secretion	NOUN
ijpds-2904	100	12	process	process	NOUN
ijpds-2904	100	13	,	,	PUNCT
ijpds-2904	100	14	consisting	consist	VERB
ijpds-2904	100	15	of	of	ADP
ijpds-2904	100	16	substrate	substrate	NOUN
ijpds-2904	100	17	uptake	uptake	ADJ
ijpds-2904	100	18	through	through	ADP
ijpds-2904	100	19	the	the	DET
ijpds-2904	100	20	baso	baso	NOUN
ijpds-2904	100	21	-	-	PUNCT
ijpds-2904	100	22	lateral	lateral	ADJ
ijpds-2904	100	23	plasma	plasma	NOUN
ijpds-2904	100	24	membrane	membrane	NOUN
ijpds-2904	100	25	(	(	PUNCT
ijpds-2904	100	26	the	the	DET
ijpds-2904	100	27	blood	blood	NOUN
ijpds-2904	100	28	-	-	PUNCT
ijpds-2904	100	29	faced	face	VERB
ijpds-2904	100	30	part	part	NOUN
ijpds-2904	100	31	of	of	ADP
ijpds-2904	100	32	plasma	plasma	NOUN
ijpds-2904	100	33	membrane	membrane	NOUN
ijpds-2904	100	34	)	)	PUNCT
ijpds-2904	100	35	.	.	PUNCT
ijpds-2904	101	1	the	the	DET
ijpds-2904	101	2	subsequent	subsequent	ADJ
ijpds-2904	101	3	substrate	substrate	NOUN
ijpds-2904	101	4	efflux	efflux	VERB
ijpds-2904	101	5	through	through	ADP
ijpds-2904	101	6	the	the	DET
ijpds-2904	101	7	luminal	luminal	ADJ
ijpds-2904	101	8	membrane	membrane	NOUN
ijpds-2904	101	9	(	(	PUNCT
ijpds-2904	101	10	the	the	DET
ijpds-2904	101	11	bileor	bileor	NOUN
ijpds-2904	101	12	urine	urine	NOUN
ijpds-2904	101	13	-	-	PUNCT
ijpds-2904	101	14	faced	face	VERB
ijpds-2904	101	15	part	part	NOUN
ijpds-2904	101	16	of	of	ADP
ijpds-2904	101	17	plasma	plasma	NOUN
ijpds-2904	101	18	membrane	membrane	NOUN
ijpds-2904	101	19	)	)	PUNCT
ijpds-2904	101	20	is	be	AUX
ijpds-2904	101	21	the	the	DET
ijpds-2904	101	22	final	final	ADJ
ijpds-2904	101	23	secretion	secretion	NOUN
ijpds-2904	101	24	step	step	NOUN
ijpds-2904	101	25	,	,	PUNCT
ijpds-2904	101	26	resulting	result	VERB
ijpds-2904	101	27	in	in	ADP
ijpds-2904	101	28	a	a	DET
ijpds-2904	101	29	vectorial	vectorial	ADJ
ijpds-2904	101	30	substrate	substrate	NOUN
ijpds-2904	101	31	movement	movement	NOUN
ijpds-2904	101	32	from	from	ADP
ijpds-2904	101	33	the	the	DET
ijpds-2904	101	34	blood	blood	NOUN
ijpds-2904	101	35	to	to	ADP
ijpds-2904	101	36	the	the	DET
ijpds-2904	101	37	bile	bile	NOUN
ijpds-2904	101	38	or	or	CCONJ
ijpds-2904	101	39	urine	urine	NOUN
ijpds-2904	101	40	in	in	ADP
ijpds-2904	101	41	the	the	DET
ijpds-2904	101	42	liver	liver	NOUN
ijpds-2904	101	43	or	or	CCONJ
ijpds-2904	101	44	kidneys	kidney	NOUN
ijpds-2904	101	45	,	,	PUNCT
ijpds-2904	101	46	respectively	respectively	ADV
ijpds-2904	101	47	.	.	PUNCT
ijpds-2904	102	1	in	in	ADP
ijpds-2904	102	2	humans	human	NOUN
ijpds-2904	102	3	the	the	DET
ijpds-2904	102	4	paralogs	paralog	VERB
ijpds-2904	102	5	hoct1	hoct1	NOUN
ijpds-2904	102	6	and	and	CCONJ
ijpds-2904	102	7	hoct2	hoct2	NOUN
ijpds-2904	102	8	are	be	AUX
ijpds-2904	102	9	specifically	specifically	ADV
ijpds-2904	102	10	expressed	express	VERB
ijpds-2904	102	11	in	in	ADP
ijpds-2904	102	12	the	the	DET
ijpds-2904	102	13	basolateral	basolateral	ADJ
ijpds-2904	102	14	membrane	membrane	NOUN
ijpds-2904	102	15	of	of	ADP
ijpds-2904	102	16	hepatocytes	hepatocyte	NOUN
ijpds-2904	102	17	and	and	CCONJ
ijpds-2904	102	18	renal	renal	ADJ
ijpds-2904	102	19	proximal	proximal	ADJ
ijpds-2904	102	20	tubule	tubule	NOUN
ijpds-2904	102	21	cells	cell	NOUN
ijpds-2904	102	22	,	,	PUNCT
ijpds-2904	102	23	respectively	respectively	ADV
ijpds-2904	102	24	[	[	X
ijpds-2904	102	25	38	38	NUM
ijpds-2904	102	26	]	]	PUNCT
ijpds-2904	102	27	.	.	PUNCT
ijpds-2904	103	1	cisplatin	cisplatin	NOUN
ijpds-2904	103	2	seems	seem	VERB
ijpds-2904	103	3	to	to	PART
ijpds-2904	103	4	interact	interact	VERB
ijpds-2904	103	5	preferentially	preferentially	ADV
ijpds-2904	103	6	with	with	ADP
ijpds-2904	103	7	hoct2	hoct2	NOUN
ijpds-2904	103	8	,	,	PUNCT
ijpds-2904	103	9	suggesting	suggest	VERB
ijpds-2904	103	10	that	that	SCONJ
ijpds-2904	103	11	hoct2	hoct2	NOUN
ijpds-2904	103	12	is	be	AUX
ijpds-2904	103	13	the	the	DET
ijpds-2904	103	14	critical	critical	ADJ
ijpds-2904	103	15	transporter	transporter	NOUN
ijpds-2904	103	16	for	for	ADP
ijpds-2904	103	17	renal	renal	ADJ
ijpds-2904	103	18	cisplatin	cisplatin	NOUN
ijpds-2904	103	19	uptake	uptake	NOUN
ijpds-2904	103	20	in	in	ADP
ijpds-2904	103	21	humans	human	NOUN
ijpds-2904	103	22	.	.	PUNCT
ijpds-2904	104	1	also	also	ADV
ijpds-2904	104	2	the	the	DET
ijpds-2904	104	3	secondand	secondand	NOUN
ijpds-2904	104	4	third	third	ADJ
ijpds-2904	104	5	generation	generation	NOUN
ijpds-2904	104	6	platinum	platinum	NOUN
ijpds-2904	104	7	derivatives	derivative	NOUN
ijpds-2904	104	8	oxaliplatin	oxaliplatin	ADV
ijpds-2904	104	9	are	be	AUX
ijpds-2904	104	10	substrates	substrate	NOUN
ijpds-2904	104	11	of	of	ADP
ijpds-2904	104	12	octs	oct	NOUN
ijpds-2904	104	13	[	[	X
ijpds-2904	104	14	38	38	NUM
ijpds-2904	104	15	]	]	PUNCT
ijpds-2904	104	16	.	.	PUNCT
ijpds-2904	105	1	for	for	ADP
ijpds-2904	105	2	the	the	DET
ijpds-2904	105	3	interpretation	interpretation	NOUN
ijpds-2904	105	4	of	of	ADP
ijpds-2904	105	5	translational	translational	ADJ
ijpds-2904	105	6	studies	study	NOUN
ijpds-2904	105	7	,	,	PUNCT
ijpds-2904	105	8	it	it	PRON
ijpds-2904	105	9	is	be	AUX
ijpds-2904	105	10	important	important	ADJ
ijpds-2904	105	11	to	to	PART
ijpds-2904	105	12	underline	underline	VERB
ijpds-2904	105	13	that	that	SCONJ
ijpds-2904	105	14	the	the	DET
ijpds-2904	105	15	rodent	rodent	NOUN
ijpds-2904	105	16	oct	oct	NOUN
ijpds-2904	105	17	orthologs	ortholog	NOUN
ijpds-2904	105	18	have	have	VERB
ijpds-2904	105	19	a	a	DET
ijpds-2904	105	20	different	different	ADJ
ijpds-2904	105	21	organ	organ	NOUN
ijpds-2904	105	22	distribution	distribution	NOUN
ijpds-2904	105	23	and	and	CCONJ
ijpds-2904	105	24	kinetic	kinetic	ADJ
ijpds-2904	105	25	properties	property	NOUN
ijpds-2904	105	26	compared	compare	VERB
ijpds-2904	105	27	with	with	ADP
ijpds-2904	105	28	human	human	ADJ
ijpds-2904	105	29	octs	oct	NOUN
ijpds-2904	105	30	:	:	PUNCT
ijpds-2904	105	31	for	for	ADP
ijpds-2904	105	32	example	example	NOUN
ijpds-2904	105	33	,	,	PUNCT
ijpds-2904	105	34	in	in	ADP
ijpds-2904	105	35	mice	mouse	NOUN
ijpds-2904	105	36	oct1	oct1	NOUN
ijpds-2904	105	37	is	be	AUX
ijpds-2904	105	38	expressed	express	VERB
ijpds-2904	105	39	in	in	ADP
ijpds-2904	105	40	renal	renal	ADJ
ijpds-2904	105	41	proximal	proximal	ADJ
ijpds-2904	105	42	tubules	tubule	NOUN
ijpds-2904	105	43	at	at	ADP
ijpds-2904	105	44	higher	high	ADJ
ijpds-2904	105	45	level	level	NOUN
ijpds-2904	105	46	than	than	ADP
ijpds-2904	105	47	oct2	oct2	NOUN
ijpds-2904	105	48	.	.	PUNCT
ijpds-2904	106	1	competition	competition	NOUN
ijpds-2904	106	2	of	of	ADP
ijpds-2904	106	3	oct	oct	PROPN
ijpds-2904	106	4	-	-	PUNCT
ijpds-2904	106	5	mediated	mediate	VERB
ijpds-2904	106	6	cisplatin	cisplatin	NOUN
ijpds-2904	106	7	transport	transport	NOUN
ijpds-2904	106	8	is	be	AUX
ijpds-2904	106	9	able	able	ADJ
ijpds-2904	106	10	to	to	PART
ijpds-2904	106	11	reduce	reduce	VERB
ijpds-2904	106	12	cisplatin	cisplatin	NOUN
ijpds-2904	106	13	uptake	uptake	NOUN
ijpds-2904	106	14	and	and	CCONJ
ijpds-2904	106	15	toxicity	toxicity	NOUN
ijpds-2904	106	16	in	in	ADP
ijpds-2904	106	17	vitro	vitro	X
ijpds-2904	106	18	and	and	CCONJ
ijpds-2904	106	19	in	in	ADP
ijpds-2904	106	20	vivo	vivo	NOUN
ijpds-2904	106	21	.	.	PUNCT
ijpds-2904	107	1	oct2	oct2	NOUN
ijpds-2904	107	2	has	have	AUX
ijpds-2904	107	3	been	be	AUX
ijpds-2904	107	4	demonstrated	demonstrate	VERB
ijpds-2904	107	5	to	to	PART
ijpds-2904	107	6	be	be	AUX
ijpds-2904	107	7	expressed	express	VERB
ijpds-2904	107	8	in	in	ADP
ijpds-2904	107	9	the	the	DET
ijpds-2904	107	10	mouse	mouse	NOUN
ijpds-2904	107	11	cochlea	cochlea	NOUN
ijpds-2904	107	12	in	in	ADP
ijpds-2904	107	13	hair	hair	NOUN
ijpds-2904	107	14	cells	cell	NOUN
ijpds-2904	107	15	of	of	ADP
ijpds-2904	107	16	organ	organ	NOUN
ijpds-2904	107	17	of	of	ADP
ijpds-2904	107	18	corti	corti	PROPN
ijpds-2904	107	19	and	and	CCONJ
ijpds-2904	107	20	in	in	ADP
ijpds-2904	107	21	the	the	DET
ijpds-2904	107	22	cells	cell	NOUN
ijpds-2904	107	23	of	of	ADP
ijpds-2904	107	24	the	the	DET
ijpds-2904	107	25	stria	stria	NOUN
ijpds-2904	107	26	vascularis	vascularis	NOUN
ijpds-2904	107	27	and	and	CCONJ
ijpds-2904	107	28	in	in	ADP
ijpds-2904	107	29	mouse	mouse	NOUN
ijpds-2904	107	30	and	and	CCONJ
ijpds-2904	107	31	human	human	ADJ
ijpds-2904	107	32	drg	drg	PROPN
ijpds-2904	107	33	)	)	PUNCT
ijpds-2904	107	34	,	,	PUNCT
ijpds-2904	107	35	structures	structure	NOUN
ijpds-2904	107	36	that	that	PRON
ijpds-2904	107	37	are	be	AUX
ijpds-2904	107	38	specially	specially	ADV
ijpds-2904	107	39	sensitive	sensitive	ADJ
ijpds-2904	107	40	to	to	ADP
ijpds-2904	107	41	toxicity	toxicity	NOUN
ijpds-2904	107	42	by	by	ADP
ijpds-2904	107	43	platinum	platinum	NOUN
ijpds-2904	107	44	-	-	PUNCT
ijpds-2904	107	45	derivatives	derivative	NOUN
ijpds-2904	107	46	.	.	PUNCT
ijpds-2904	108	1	in	in	ADP
ijpds-2904	108	2	animal	animal	NOUN
ijpds-2904	108	3	models	model	NOUN
ijpds-2904	108	4	it	it	PRON
ijpds-2904	108	5	has	have	AUX
ijpds-2904	108	6	been	be	AUX
ijpds-2904	108	7	demonstrated	demonstrate	VERB
ijpds-2904	108	8	that	that	SCONJ
ijpds-2904	108	9	octs	oct	NOUN
ijpds-2904	108	10	are	be	AUX
ijpds-2904	108	11	critical	critical	ADJ
ijpds-2904	108	12	mediators	mediator	NOUN
ijpds-2904	108	13	of	of	ADP
ijpds-2904	108	14	cisplatin	cisplatin	NOUN
ijpds-2904	108	15	ototoxicity	ototoxicity	NOUN
ijpds-2904	108	16	and	and	CCONJ
ijpds-2904	108	17	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	108	18	peripheral	peripheral	ADJ
ijpds-2904	108	19	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	108	20	[	[	X
ijpds-2904	108	21	5	5	NUM
ijpds-2904	108	22	]	]	PUNCT
ijpds-2904	108	23	.	.	PUNCT
ijpds-2904	109	1	multidrug	multidrug	NOUN
ijpds-2904	109	2	and	and	CCONJ
ijpds-2904	109	3	toxin	toxin	NOUN
ijpds-2904	109	4	extrusion	extrusion	NOUN
ijpds-2904	109	5	protein	protein	NOUN
ijpds-2904	109	6	1	1	NUM
ijpds-2904	109	7	(	(	PUNCT
ijpds-2904	109	8	mate1	mate1	NOUN
ijpds-2904	109	9	,	,	PUNCT
ijpds-2904	109	10	slc47a1	slc47a1	NOUN
ijpds-2904	109	11	)	)	PUNCT
ijpds-2904	109	12	several	several	ADJ
ijpds-2904	109	13	evidences	evidence	NOUN
ijpds-2904	109	14	indicate	indicate	VERB
ijpds-2904	109	15	that	that	SCONJ
ijpds-2904	109	16	mate1	mate1	NOUN
ijpds-2904	109	17	mediates	mediate	VERB
ijpds-2904	109	18	secretion	secretion	NOUN
ijpds-2904	109	19	of	of	ADP
ijpds-2904	109	20	cisplatin	cisplatin	NOUN
ijpds-2904	109	21	into	into	ADP
ijpds-2904	109	22	the	the	DET
ijpds-2904	109	23	urine	urine	NOUN
ijpds-2904	109	24	.	.	PUNCT
ijpds-2904	110	1	mice	mouse	NOUN
ijpds-2904	110	2	with	with	ADP
ijpds-2904	110	3	genetic	genetic	ADJ
ijpds-2904	110	4	deletion	deletion	NOUN
ijpds-2904	110	5	of	of	ADP
ijpds-2904	110	6	mate1	mate1	NOUN
ijpds-2904	110	7	are	be	AUX
ijpds-2904	110	8	more	more	ADV
ijpds-2904	110	9	sensitive	sensitive	ADJ
ijpds-2904	110	10	to	to	ADP
ijpds-2904	110	11	cisplatin	cisplatin	NOUN
ijpds-2904	110	12	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	110	13	[	[	X
ijpds-2904	110	14	39	39	NUM
ijpds-2904	110	15	]	]	PUNCT
ijpds-2904	110	16	.	.	PUNCT
ijpds-2904	111	1	furthermore	furthermore	ADV
ijpds-2904	111	2	,	,	PUNCT
ijpds-2904	111	3	cell	cell	NOUN
ijpds-2904	111	4	transfected	transfecte	VERB
ijpds-2904	111	5	with	with	ADP
ijpds-2904	111	6	mate1	mate1	NOUN
ijpds-2904	111	7	displayed	display	VERB
ijpds-2904	111	8	a	a	DET
ijpds-2904	111	9	higher	high	ADJ
ijpds-2904	111	10	cisplatin	cisplatin	NOUN
ijpds-2904	111	11	uptake	uptake	NOUN
ijpds-2904	111	12	than	than	ADP
ijpds-2904	111	13	control	control	NOUN
ijpds-2904	111	14	cells	cell	NOUN
ijpds-2904	111	15	.	.	PUNCT
ijpds-2904	112	1	interestingly	interestingly	ADV
ijpds-2904	112	2	,	,	PUNCT
ijpds-2904	112	3	mate1	mate1	NOUN
ijpds-2904	112	4	and	and	CCONJ
ijpds-2904	112	5	sakshi	sakshi	PROPN
ijpds-2904	112	6	and	and	CCONJ
ijpds-2904	112	7	singh	singh	PROPN
ijpds-2904	112	8	cisplatin	cisplatin	NOUN
ijpds-2904	112	9	induced	induce	VERB
ijpds-2904	112	10	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	112	11	vol	vol	NOUN
ijpds-2904	112	12	1	1	NUM
ijpds-2904	112	13	|	|	NOUN
ijpds-2904	112	14	issue	issue	VERB
ijpds-2904	112	15	1	1	NUM
ijpds-2904	112	16	|	|	ADV
ijpds-2904	112	17	apr	apr	ADV
ijpds-2904	112	18	–	–	PUNCT
ijpds-2904	112	19	jun	jun	PROPN
ijpds-2904	112	20	2022	2022	NUM
ijpds-2904	112	21	indian	indian	PROPN
ijpds-2904	112	22	j	j	PROPN
ijpds-2904	112	23	pharm	pharm	PROPN
ijpds-2904	112	24	drug	drug	PROPN
ijpds-2904	112	25	studies	study	NOUN
ijpds-2904	112	26	|	|	ADV
ijpds-2904	112	27	8	8	NUM
ijpds-2904	112	28	mate2	mate2	NOUN
ijpds-2904	112	29	-	-	PUNCT
ijpds-2904	112	30	k	k	NOUN
ijpds-2904	112	31	,	,	PUNCT
ijpds-2904	112	32	another	another	DET
ijpds-2904	112	33	member	member	NOUN
ijpds-2904	112	34	of	of	ADP
ijpds-2904	112	35	mate	mate	NOUN
ijpds-2904	112	36	family	family	NOUN
ijpds-2904	112	37	which	which	PRON
ijpds-2904	112	38	is	be	AUX
ijpds-2904	112	39	solely	solely	ADV
ijpds-2904	112	40	expressed	express	VERB
ijpds-2904	112	41	in	in	ADP
ijpds-2904	112	42	human	human	ADJ
ijpds-2904	112	43	kidneys	kidney	NOUN
ijpds-2904	112	44	,	,	PUNCT
ijpds-2904	112	45	seem	seem	VERB
ijpds-2904	112	46	to	to	PART
ijpds-2904	112	47	transport	transport	VERB
ijpds-2904	112	48	oxaliplatin	oxaliplatin	ADV
ijpds-2904	112	49	with	with	ADP
ijpds-2904	112	50	higher	high	ADJ
ijpds-2904	112	51	affinity	affinity	NOUN
ijpds-2904	112	52	than	than	ADP
ijpds-2904	112	53	cisplatin	cisplatin	NOUN
ijpds-2904	112	54	,	,	PUNCT
ijpds-2904	112	55	offering	offer	VERB
ijpds-2904	112	56	a	a	DET
ijpds-2904	112	57	possible	possible	ADJ
ijpds-2904	112	58	explanation	explanation	NOUN
ijpds-2904	112	59	of	of	ADP
ijpds-2904	112	60	the	the	DET
ijpds-2904	112	61	low	low	ADJ
ijpds-2904	112	62	oxaliplatin	oxaliplatin	PROPN
ijpds-2904	112	63	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	112	64	.	.	PUNCT
ijpds-2904	113	1	as	as	SCONJ
ijpds-2904	113	2	outlined	outline	VERB
ijpds-2904	113	3	above	above	ADV
ijpds-2904	113	4	,	,	PUNCT
ijpds-2904	113	5	inhibition	inhibition	NOUN
ijpds-2904	113	6	of	of	ADP
ijpds-2904	113	7	oct2	oct2	NOUN
ijpds-2904	113	8	may	may	AUX
ijpds-2904	113	9	be	be	AUX
ijpds-2904	113	10	a	a	DET
ijpds-2904	113	11	protective	protective	ADJ
ijpds-2904	113	12	strategy	strategy	NOUN
ijpds-2904	113	13	against	against	ADP
ijpds-2904	113	14	cisplatin	cisplatin	NOUN
ijpds-2904	113	15	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	113	16	[	[	X
ijpds-2904	113	17	40	40	NUM
ijpds-2904	113	18	]	]	PUNCT
ijpds-2904	113	19	.	.	PUNCT
ijpds-2904	114	1	however	however	ADV
ijpds-2904	114	2	,	,	PUNCT
ijpds-2904	114	3	some	some	DET
ijpds-2904	114	4	inhibitors	inhibitor	NOUN
ijpds-2904	114	5	of	of	ADP
ijpds-2904	114	6	oct2	oct2	NOUN
ijpds-2904	114	7	such	such	ADJ
ijpds-2904	114	8	as	as	ADP
ijpds-2904	114	9	cimetidine	cimetidine	NOUN
ijpds-2904	114	10	and	and	CCONJ
ijpds-2904	114	11	ondansetron	ondansetron	NOUN
ijpds-2904	114	12	interact	interact	NOUN
ijpds-2904	114	13	with	with	ADP
ijpds-2904	114	14	higher	high	ADJ
ijpds-2904	114	15	potency	potency	NOUN
ijpds-2904	114	16	with	with	ADP
ijpds-2904	114	17	mate1	mate1	NOUN
ijpds-2904	114	18	,	,	PUNCT
ijpds-2904	114	19	blocking	block	VERB
ijpds-2904	114	20	cisplatin	cisplatin	NOUN
ijpds-2904	114	21	efflux	efflux	VERB
ijpds-2904	114	22	from	from	ADP
ijpds-2904	114	23	the	the	DET
ijpds-2904	114	24	cells	cell	NOUN
ijpds-2904	114	25	and	and	CCONJ
ijpds-2904	114	26	potentially	potentially	ADV
ijpds-2904	114	27	increasing	increase	VERB
ijpds-2904	114	28	cisplatin	cisplatin	NOUN
ijpds-2904	114	29	renal	renal	ADJ
ijpds-2904	114	30	toxicity	toxicity	NOUN
ijpds-2904	114	31	[	[	X
ijpds-2904	114	32	41	41	NUM
ijpds-2904	114	33	]	]	PUNCT
ijpds-2904	114	34	.	.	PUNCT
ijpds-2904	115	1	indeed	indeed	ADV
ijpds-2904	115	2	,	,	PUNCT
ijpds-2904	115	3	co	co	NOUN
ijpds-2904	115	4	-	-	NOUN
ijpds-2904	115	5	treatment	treatment	NOUN
ijpds-2904	115	6	of	of	ADP
ijpds-2904	115	7	mice	mouse	NOUN
ijpds-2904	115	8	with	with	ADP
ijpds-2904	115	9	cisplatin	cisplatin	NOUN
ijpds-2904	115	10	and	and	CCONJ
ijpds-2904	115	11	cimetidine	cimetidine	NOUN
ijpds-2904	115	12	was	be	AUX
ijpds-2904	115	13	effective	effective	ADJ
ijpds-2904	115	14	in	in	ADP
ijpds-2904	115	15	protecting	protect	VERB
ijpds-2904	115	16	the	the	DET
ijpds-2904	115	17	animals	animal	NOUN
ijpds-2904	115	18	from	from	ADP
ijpds-2904	115	19	ototoxicity	ototoxicity	NOUN
ijpds-2904	115	20	but	but	CCONJ
ijpds-2904	115	21	not	not	PART
ijpds-2904	115	22	from	from	ADP
ijpds-2904	115	23	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	115	24	[	[	X
ijpds-2904	115	25	42	42	NUM
ijpds-2904	115	26	]	]	PUNCT
ijpds-2904	115	27	.	.	PUNCT
ijpds-2904	116	1	there	there	PRON
ijpds-2904	116	2	are	be	VERB
ijpds-2904	116	3	some	some	DET
ijpds-2904	116	4	investigations	investigation	NOUN
ijpds-2904	116	5	suggesting	suggest	VERB
ijpds-2904	116	6	a	a	DET
ijpds-2904	116	7	role	role	NOUN
ijpds-2904	116	8	of	of	ADP
ijpds-2904	116	9	novel	novel	ADJ
ijpds-2904	116	10	organic	organic	ADJ
ijpds-2904	116	11	cation	cation	NOUN
ijpds-2904	116	12	transporters	transporter	NOUN
ijpds-2904	116	13	(	(	PUNCT
ijpds-2904	116	14	octns	octns	NOUN
ijpds-2904	116	15	)	)	PUNCT
ijpds-2904	116	16	for	for	ADP
ijpds-2904	116	17	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	116	18	transport	transport	NOUN
ijpds-2904	116	19	.	.	PUNCT
ijpds-2904	117	1	these	these	DET
ijpds-2904	117	2	transporters	transporter	NOUN
ijpds-2904	117	3	are	be	AUX
ijpds-2904	117	4	expressed	express	VERB
ijpds-2904	117	5	on	on	ADP
ijpds-2904	117	6	the	the	DET
ijpds-2904	117	7	apical	apical	ADJ
ijpds-2904	117	8	membrane	membrane	NOUN
ijpds-2904	117	9	of	of	ADP
ijpds-2904	117	10	renal	renal	ADJ
ijpds-2904	117	11	proximal	proximal	ADJ
ijpds-2904	117	12	tubule	tubule	NOUN
ijpds-2904	117	13	cells	cell	NOUN
ijpds-2904	117	14	and	and	CCONJ
ijpds-2904	117	15	in	in	ADP
ijpds-2904	117	16	rat	rat	NOUN
ijpds-2904	117	17	drgs	drgs	PROPN
ijpds-2904	117	18	.	.	PUNCT
ijpds-2904	118	1	when	when	SCONJ
ijpds-2904	118	2	transfected	transfecte	VERB
ijpds-2904	118	3	in	in	ADP
ijpds-2904	118	4	human	human	ADJ
ijpds-2904	118	5	embryonic	embryonic	ADJ
ijpds-2904	118	6	kidney	kidney	NOUN
ijpds-2904	118	7	cells	cell	NOUN
ijpds-2904	118	8	,	,	PUNCT
ijpds-2904	118	9	rat	rat	NOUN
ijpds-2904	118	10	and	and	CCONJ
ijpds-2904	118	11	human	human	ADJ
ijpds-2904	118	12	octn1	octn1	PROPN
ijpds-2904	118	13	and	and	CCONJ
ijpds-2904	118	14	octn2	octn2	ADJ
ijpds-2904	118	15	mediate	mediate	VERB
ijpds-2904	118	16	significant	significant	ADJ
ijpds-2904	118	17	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	118	18	uptake	uptake	NOUN
ijpds-2904	118	19	,	,	PUNCT
ijpds-2904	118	20	suggesting	suggest	VERB
ijpds-2904	118	21	that	that	DET
ijpds-2904	118	22	octns	octns	NOUN
ijpds-2904	118	23	are	be	AUX
ijpds-2904	118	24	involved	involve	VERB
ijpds-2904	118	25	in	in	ADP
ijpds-2904	118	26	oxaliplatin	oxaliplatin	ADJ
ijpds-2904	118	27	neurotoxicity	neurotoxicity	NOUN
ijpds-2904	118	28	[	[	X
ijpds-2904	118	29	26	26	NUM
ijpds-2904	118	30	]	]	PUNCT
ijpds-2904	118	31	.	.	PUNCT
ijpds-2904	119	1	apart	apart	ADV
ijpds-2904	119	2	from	from	ADP
ijpds-2904	119	3	these	these	DET
ijpds-2904	119	4	not	not	PART
ijpds-2904	119	5	directly	directly	ADV
ijpds-2904	119	6	atp	atp	NOUN
ijpds-2904	119	7	-	-	PUNCT
ijpds-2904	119	8	dependent	dependent	ADJ
ijpds-2904	119	9	transporters	transporter	NOUN
ijpds-2904	119	10	,	,	PUNCT
ijpds-2904	119	11	multidrug	multidrug	VERB
ijpds-2904	119	12	resistance	resistance	NOUN
ijpds-2904	119	13	-	-	PUNCT
ijpds-2904	119	14	associated	associate	VERB
ijpds-2904	119	15	protein	protein	NOUN
ijpds-2904	119	16	2	2	NUM
ijpds-2904	119	17	(	(	PUNCT
ijpds-2904	119	18	mrp2	mrp2	PROPN
ijpds-2904	119	19	)	)	PUNCT
ijpds-2904	119	20	transporter	transporter	NOUN
ijpds-2904	119	21	seems	seem	VERB
ijpds-2904	119	22	to	to	PART
ijpds-2904	119	23	be	be	AUX
ijpds-2904	119	24	involved	involve	VERB
ijpds-2904	119	25	in	in	ADP
ijpds-2904	119	26	the	the	DET
ijpds-2904	119	27	efflux	efflux	NOUN
ijpds-2904	119	28	of	of	ADP
ijpds-2904	119	29	cisplatin	cisplatin	NOUN
ijpds-2904	119	30	and	and	CCONJ
ijpds-2904	119	31	its	its	PRON
ijpds-2904	119	32	conjugates	conjugate	NOUN
ijpds-2904	119	33	from	from	ADP
ijpds-2904	119	34	kidney	kidney	NOUN
ijpds-2904	119	35	cells	cell	NOUN
ijpds-2904	119	36	,	,	PUNCT
ijpds-2904	119	37	and	and	CCONJ
ijpds-2904	119	38	for	for	ADP
ijpds-2904	119	39	this	this	DET
ijpds-2904	119	40	reason	reason	NOUN
ijpds-2904	119	41	to	to	PART
ijpds-2904	119	42	play	play	VERB
ijpds-2904	119	43	an	an	DET
ijpds-2904	119	44	important	important	ADJ
ijpds-2904	119	45	role	role	NOUN
ijpds-2904	119	46	for	for	ADP
ijpds-2904	119	47	control	control	NOUN
ijpds-2904	119	48	of	of	ADP
ijpds-2904	119	49	cisplatin	cisplatin	NOUN
ijpds-2904	119	50	renal	renal	ADJ
ijpds-2904	119	51	toxicity	toxicity	NOUN
ijpds-2904	119	52	[	[	X
ijpds-2904	119	53	43	43	NUM
ijpds-2904	119	54	]	]	PUNCT
ijpds-2904	119	55	.	.	PUNCT
ijpds-2904	120	1	conclusion	conclusion	NOUN
ijpds-2904	120	2	cellular	cellular	ADJ
ijpds-2904	120	3	transport	transport	NOUN
ijpds-2904	120	4	of	of	ADP
ijpds-2904	120	5	platinum	platinum	NOUN
ijpds-2904	120	6	derivatives	derivative	NOUN
ijpds-2904	120	7	is	be	AUX
ijpds-2904	120	8	mediated	mediate	VERB
ijpds-2904	120	9	by	by	ADP
ijpds-2904	120	10	several	several	ADJ
ijpds-2904	120	11	transport	transport	NOUN
ijpds-2904	120	12	systems	system	NOUN
ijpds-2904	120	13	.	.	PUNCT
ijpds-2904	121	1	some	some	DET
ijpds-2904	121	2	transporters	transporter	NOUN
ijpds-2904	121	3	,	,	PUNCT
ijpds-2904	121	4	such	such	ADJ
ijpds-2904	121	5	as	as	ADP
ijpds-2904	121	6	octs	oct	NOUN
ijpds-2904	121	7	,	,	PUNCT
ijpds-2904	121	8	are	be	AUX
ijpds-2904	121	9	specifically	specifically	ADV
ijpds-2904	121	10	expressed	express	VERB
ijpds-2904	121	11	in	in	ADP
ijpds-2904	121	12	organs	organ	NOUN
ijpds-2904	121	13	,	,	PUNCT
ijpds-2904	121	14	which	which	PRON
ijpds-2904	121	15	are	be	AUX
ijpds-2904	121	16	damaged	damage	VERB
ijpds-2904	121	17	by	by	ADP
ijpds-2904	121	18	antitumor	antitumor	PROPN
ijpds-2904	121	19	therapy	therapy	NOUN
ijpds-2904	121	20	with	with	ADP
ijpds-2904	121	21	platinum	platinum	NOUN
ijpds-2904	121	22	derivatives	derivative	NOUN
ijpds-2904	121	23	.	.	PUNCT
ijpds-2904	122	1	for	for	ADP
ijpds-2904	122	2	this	this	DET
ijpds-2904	122	3	reason	reason	NOUN
ijpds-2904	122	4	,	,	PUNCT
ijpds-2904	122	5	they	they	PRON
ijpds-2904	122	6	may	may	AUX
ijpds-2904	122	7	be	be	AUX
ijpds-2904	122	8	a	a	DET
ijpds-2904	122	9	target	target	NOUN
ijpds-2904	122	10	for	for	ADP
ijpds-2904	122	11	protective	protective	ADJ
ijpds-2904	122	12	intervention	intervention	NOUN
ijpds-2904	122	13	.	.	PUNCT
ijpds-2904	123	1	however	however	ADV
ijpds-2904	123	2	,	,	PUNCT
ijpds-2904	123	3	an	an	DET
ijpds-2904	123	4	efficient	efficient	ADJ
ijpds-2904	123	5	protection	protection	NOUN
ijpds-2904	123	6	can	can	AUX
ijpds-2904	123	7	be	be	AUX
ijpds-2904	123	8	only	only	ADV
ijpds-2904	123	9	reached	reach	VERB
ijpds-2904	123	10	by	by	ADP
ijpds-2904	123	11	specific	specific	ADJ
ijpds-2904	123	12	inhibition	inhibition	NOUN
ijpds-2904	123	13	of	of	ADP
ijpds-2904	123	14	octs	oct	NOUN
ijpds-2904	123	15	.	.	PUNCT
ijpds-2904	124	1	references	reference	NOUN
ijpds-2904	124	2	1	1	NUM
ijpds-2904	124	3	.	.	PUNCT
ijpds-2904	125	1	bastiancich	bastiancich	PROPN
ijpds-2904	125	2	c	c	NOUN
ijpds-2904	125	3	,	,	PUNCT
ijpds-2904	125	4	danhier	danhier	NOUN
ijpds-2904	125	5	p	p	NOUN
ijpds-2904	125	6	,	,	PUNCT
ijpds-2904	125	7	préat	préat	NOUN
ijpds-2904	125	8	v	v	NOUN
ijpds-2904	125	9	,	,	PUNCT
ijpds-2904	125	10	et	et	PROPN
ijpds-2904	125	11	al	al	PROPN
ijpds-2904	125	12	.	.	PROPN
ijpds-2904	125	13	anticancer	anticancer	NOUN
ijpds-2904	125	14	drug	drug	NOUN
ijpds-2904	125	15	-	-	PUNCT
ijpds-2904	125	16	loaded	load	VERB
ijpds-2904	125	17	hydrogels	hydrogel	NOUN
ijpds-2904	125	18	as	as	ADP
ijpds-2904	125	19	drug	drug	NOUN
ijpds-2904	125	20	delivery	delivery	NOUN
ijpds-2904	125	21	systems	system	NOUN
ijpds-2904	125	22	for	for	ADP
ijpds-2904	125	23	the	the	DET
ijpds-2904	125	24	local	local	ADJ
ijpds-2904	125	25	treatment	treatment	NOUN
ijpds-2904	125	26	of	of	ADP
ijpds-2904	125	27	glioblastoma	glioblastoma	NOUN
ijpds-2904	125	28	.	.	PUNCT
ijpds-2904	126	1	j	j	PROPN
ijpds-2904	126	2	control	control	PROPN
ijpds-2904	126	3	release	release	PROPN
ijpds-2904	126	4	.	.	PUNCT
ijpds-2904	127	1	2016	2016	NUM
ijpds-2904	127	2	,	,	PUNCT
ijpds-2904	127	3	243:29–42	243:29–42	NUM
ijpds-2904	127	4	.	.	PROPN
ijpds-2904	128	1	2	2	NUM
ijpds-2904	128	2	.	.	NOUN
ijpds-2904	128	3	odds	odd	NOUN
ijpds-2904	128	4	fc	fc	PROPN
ijpds-2904	128	5	,	,	PUNCT
ijpds-2904	128	6	brown	brown	PROPN
ijpds-2904	128	7	ajp	ajp	PROPN
ijpds-2904	128	8	,	,	PUNCT
ijpds-2904	128	9	gow	gow	NOUN
ijpds-2904	128	10	nar	nar	NOUN
ijpds-2904	128	11	.	.	PUNCT
ijpds-2904	129	1	antifungal	antifungal	ADJ
ijpds-2904	129	2	agents	agent	NOUN
ijpds-2904	129	3	:	:	PUNCT
ijpds-2904	129	4	mechanisms	mechanism	NOUN
ijpds-2904	129	5	of	of	ADP
ijpds-2904	129	6	action	action	NOUN
ijpds-2904	129	7	.	.	PUNCT
ijpds-2904	130	1	trends	trend	NOUN
ijpds-2904	130	2	microbiol	microbiol	PROPN
ijpds-2904	130	3	.	.	PUNCT
ijpds-2904	131	1	2003	2003	NUM
ijpds-2904	131	2	,	,	PUNCT
ijpds-2904	131	3	11:272–9	11:272–9	NUM
ijpds-2904	131	4	.	.	X
ijpds-2904	132	1	3	3	X
ijpds-2904	132	2	.	.	NOUN
ijpds-2904	132	3	hucke	hucke	PROPN
ijpds-2904	132	4	a	a	X
ijpds-2904	132	5	,	,	PUNCT
ijpds-2904	132	6	ciarimboli	ciarimboli	NOUN
ijpds-2904	132	7	g.	g.	VERB
ijpds-2904	132	8	the	the	DET
ijpds-2904	132	9	role	role	NOUN
ijpds-2904	132	10	of	of	ADP
ijpds-2904	132	11	transporters	transporter	NOUN
ijpds-2904	132	12	in	in	ADP
ijpds-2904	132	13	the	the	DET
ijpds-2904	132	14	toxicity	toxicity	NOUN
ijpds-2904	132	15	of	of	ADP
ijpds-2904	132	16	chemotherapeutic	chemotherapeutic	ADJ
ijpds-2904	132	17	drugs	drug	NOUN
ijpds-2904	132	18	:	:	PUNCT
ijpds-2904	132	19	focus	focus	VERB
ijpds-2904	132	20	on	on	ADP
ijpds-2904	132	21	transporters	transporter	NOUN
ijpds-2904	132	22	for	for	ADP
ijpds-2904	132	23	organic	organic	ADJ
ijpds-2904	132	24	cations	cation	NOUN
ijpds-2904	132	25	.	.	PUNCT
ijpds-2904	133	1	j	j	PROPN
ijpds-2904	133	2	clin	clin	PROPN
ijpds-2904	133	3	pharmacol	pharmacol	PROPN
ijpds-2904	133	4	.	.	PROPN
ijpds-2904	134	1	2016	2016	NUM
ijpds-2904	134	2	,	,	PUNCT
ijpds-2904	134	3	s157–72	s157–72	PROPN
ijpds-2904	134	4	.	.	PROPN
ijpds-2904	134	5	10.1002	10.1002	NUM
ijpds-2904	134	6	/	/	SYM
ijpds-2904	134	7	jcph.706	jcph.706	PROPN
ijpds-2904	134	8	4	4	NUM
ijpds-2904	134	9	.	.	PUNCT
ijpds-2904	134	10	chancy	chancy	PROPN
ijpds-2904	134	11	cd	cd	PROPN
ijpds-2904	134	12	,	,	PUNCT
ijpds-2904	134	13	kekuda	kekuda	NOUN
ijpds-2904	134	14	r	r	PROPN
ijpds-2904	134	15	,	,	PUNCT
ijpds-2904	134	16	huang	huang	PROPN
ijpds-2904	134	17	w	w	PROPN
ijpds-2904	134	18	,	,	PUNCT
ijpds-2904	134	19	et	et	PROPN
ijpds-2904	134	20	al	al	PROPN
ijpds-2904	134	21	.	.	PUNCT
ijpds-2904	135	1	expression	expression	NOUN
ijpds-2904	135	2	and	and	CCONJ
ijpds-2904	135	3	differential	differential	ADJ
ijpds-2904	135	4	polarization	polarization	NOUN
ijpds-2904	135	5	of	of	ADP
ijpds-2904	135	6	the	the	DET
ijpds-2904	135	7	reduced	reduce	VERB
ijpds-2904	135	8	-	-	PUNCT
ijpds-2904	135	9	folate	folate	NOUN
ijpds-2904	135	10	transporter-1	transporter-1	NUM
ijpds-2904	135	11	and	and	CCONJ
ijpds-2904	135	12	the	the	DET
ijpds-2904	135	13	folate	folate	NOUN
ijpds-2904	135	14	receptor	receptor	NOUN
ijpds-2904	135	15	α	α	NOUN
ijpds-2904	135	16	in	in	ADP
ijpds-2904	135	17	mammalian	mammalian	ADJ
ijpds-2904	135	18	retinal	retinal	ADJ
ijpds-2904	135	19	pigment	pigment	NOUN
ijpds-2904	135	20	epithelium	epithelium	NOUN
ijpds-2904	135	21	.	.	PUNCT
ijpds-2904	136	1	j	j	PROPN
ijpds-2904	136	2	biol	biol	PROPN
ijpds-2904	136	3	chem	chem	NOUN
ijpds-2904	136	4	.	.	PUNCT
ijpds-2904	137	1	2000	2000	NUM
ijpds-2904	137	2	,	,	PUNCT
ijpds-2904	137	3	275:20676–84	275:20676–84	NOUN
ijpds-2904	137	4	.	.	PUNCT
ijpds-2904	138	1	5	5	X
ijpds-2904	138	2	.	.	X
ijpds-2904	138	3	ciarimboli	ciarimboli	NOUN
ijpds-2904	138	4	g.	g.	PROPN
ijpds-2904	138	5	membrane	membrane	NOUN
ijpds-2904	138	6	transporters	transporter	NOUN
ijpds-2904	138	7	as	as	ADP
ijpds-2904	138	8	mediators	mediator	NOUN
ijpds-2904	138	9	of	of	ADP
ijpds-2904	138	10	cisplatin	cisplatin	NOUN
ijpds-2904	138	11	side	side	NOUN
ijpds-2904	138	12	-	-	PUNCT
ijpds-2904	138	13	effects	effect	NOUN
ijpds-2904	138	14	.	.	PUNCT
ijpds-2904	139	1	anticancer	anticancer	NOUN
ijpds-2904	139	2	res	re	NOUN
ijpds-2904	139	3	.	.	PROPN
ijpds-2904	139	4	2014	2014	NUM
ijpds-2904	139	5	,	,	PUNCT
ijpds-2904	139	6	34:547–50	34:547–50	NOUN
ijpds-2904	139	7	.	.	PUNCT
ijpds-2904	140	1	6	6	NUM
ijpds-2904	140	2	.	.	X
ijpds-2904	140	3	pabla	pabla	PROPN
ijpds-2904	140	4	m.	m.	PROPN
ijpds-2904	140	5	the	the	DET
ijpds-2904	140	6	copper	copper	NOUN
ijpds-2904	140	7	transporter	transporter	NOUN
ijpds-2904	140	8	ctr1	ctr1	NOUN
ijpds-2904	140	9	contributes	contribute	VERB
ijpds-2904	140	10	to	to	ADP
ijpds-2904	140	11	cisplatin	cisplatin	NOUN
ijpds-2904	140	12	uptake	uptake	NOUN
ijpds-2904	140	13	by	by	ADP
ijpds-2904	140	14	renal	renal	ADJ
ijpds-2904	140	15	tubular	tubular	ADJ
ijpds-2904	140	16	cells	cell	NOUN
ijpds-2904	140	17	during	during	ADP
ijpds-2904	140	18	cisplatin	cisplatin	NOUN
ijpds-2904	140	19	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	140	20	.	.	PUNCT
ijpds-2904	141	1	am	be	AUX
ijpds-2904	141	2	j	j	PROPN
ijpds-2904	141	3	renal	renal	PROPN
ijpds-2904	141	4	physiol	physiol	PROPN
ijpds-2904	141	5	.	.	PUNCT
ijpds-2904	142	1	2009	2009	NUM
ijpds-2904	142	2	,	,	PUNCT
ijpds-2904	142	3	31:505	31:505	NUM
ijpds-2904	142	4	-	-	SYM
ijpds-2904	142	5	511	511	NUM
ijpds-2904	142	6	.	.	PUNCT
ijpds-2904	143	1	7	7	X
ijpds-2904	143	2	.	.	X
ijpds-2904	144	1	wang	wang	PROPN
ijpds-2904	144	2	d	d	PROPN
ijpds-2904	144	3	,	,	PUNCT
ijpds-2904	144	4	lippard	lippard	ADJ
ijpds-2904	144	5	sj	sj	PROPN
ijpds-2904	144	6	.	.	PUNCT
ijpds-2904	144	7	cellular	cellular	ADJ
ijpds-2904	144	8	processing	processing	NOUN
ijpds-2904	144	9	of	of	ADP
ijpds-2904	144	10	platinum	platinum	NOUN
ijpds-2904	144	11	anticancer	anticancer	NOUN
ijpds-2904	144	12	drugs	drug	NOUN
ijpds-2904	144	13	.	.	PUNCT
ijpds-2904	145	1	nat	nat	PROPN
ijpds-2904	145	2	rev	rev	VERB
ijpds-2904	145	3	drug	drug	NOUN
ijpds-2904	145	4	discov	discov	NOUN
ijpds-2904	145	5	.	.	PUNCT
ijpds-2904	146	1	2005	2005	NUM
ijpds-2904	146	2	,	,	PUNCT
ijpds-2904	146	3	4:307–20	4:307–20	NUM
ijpds-2904	146	4	.	.	NOUN
ijpds-2904	146	5	8	8	NUM
ijpds-2904	146	6	.	.	X
ijpds-2904	146	7	florea	florea	PROPN
ijpds-2904	146	8	a	a	DET
ijpds-2904	146	9	-	-	PUNCT
ijpds-2904	146	10	m	m	NOUN
ijpds-2904	146	11	,	,	PUNCT
ijpds-2904	146	12	büsselberg	büsselberg	PROPN
ijpds-2904	146	13	d.	d.	PROPN
ijpds-2904	146	14	cisplatin	cisplatin	PROPN
ijpds-2904	146	15	as	as	ADP
ijpds-2904	146	16	an	an	DET
ijpds-2904	146	17	anti	anti	ADJ
ijpds-2904	146	18	-	-	ADJ
ijpds-2904	146	19	tumor	tumor	ADJ
ijpds-2904	146	20	drug	drug	NOUN
ijpds-2904	146	21	:	:	PUNCT
ijpds-2904	146	22	cellular	cellular	ADJ
ijpds-2904	146	23	mechanisms	mechanism	NOUN
ijpds-2904	146	24	of	of	ADP
ijpds-2904	146	25	activity	activity	NOUN
ijpds-2904	146	26	,	,	PUNCT
ijpds-2904	146	27	drug	drug	NOUN
ijpds-2904	146	28	resistance	resistance	NOUN
ijpds-2904	146	29	and	and	CCONJ
ijpds-2904	146	30	induced	induce	VERB
ijpds-2904	146	31	side	side	NOUN
ijpds-2904	146	32	effects	effect	NOUN
ijpds-2904	146	33	.	.	PUNCT
ijpds-2904	147	1	cancers	cancer	NOUN
ijpds-2904	147	2	(	(	PUNCT
ijpds-2904	147	3	basel	basel	PROPN
ijpds-2904	147	4	)	)	PUNCT
ijpds-2904	147	5	.	.	PUNCT
ijpds-2904	148	1	2011	2011	NUM
ijpds-2904	148	2	,	,	PUNCT
ijpds-2904	148	3	3:1351–71	3:1351–71	NOUN
ijpds-2904	148	4	.	.	PUNCT
ijpds-2904	149	1	9	9	X
ijpds-2904	149	2	.	.	X
ijpds-2904	149	3	dasari	dasari	PROPN
ijpds-2904	149	4	s	s	PROPN
ijpds-2904	149	5	,	,	PUNCT
ijpds-2904	149	6	tchounwou	tchounwou	NOUN
ijpds-2904	149	7	pb	pb	ADP
ijpds-2904	149	8	.	.	PUNCT
ijpds-2904	149	9	cisplatin	cisplatin	NOUN
ijpds-2904	149	10	in	in	ADP
ijpds-2904	149	11	cancer	cancer	NOUN
ijpds-2904	149	12	therapy	therapy	NOUN
ijpds-2904	149	13	:	:	PUNCT
ijpds-2904	149	14	molecular	molecular	ADJ
ijpds-2904	149	15	mechanisms	mechanism	NOUN
ijpds-2904	149	16	of	of	ADP
ijpds-2904	149	17	action	action	NOUN
ijpds-2904	149	18	.	.	PUNCT
ijpds-2904	150	1	eur	eur	PROPN
ijpds-2904	150	2	j	j	PROPN
ijpds-2904	150	3	pharmacol	pharmacol	PROPN
ijpds-2904	150	4	.	.	PROPN
ijpds-2904	151	1	2014	2014	NUM
ijpds-2904	151	2	,	,	PUNCT
ijpds-2904	151	3	740:364–78	740:364–78	NUM
ijpds-2904	151	4	.	.	PUNCT
ijpds-2904	152	1	10	10	NUM
ijpds-2904	152	2	.	.	PUNCT
ijpds-2904	153	1	harrach	harrach	PROPN
ijpds-2904	153	2	s	s	SYM
ijpds-2904	153	3	,	,	PUNCT
ijpds-2904	153	4	ciarimboli	ciarimboli	NOUN
ijpds-2904	153	5	g.	g.	NOUN
ijpds-2904	153	6	role	role	NOUN
ijpds-2904	153	7	of	of	ADP
ijpds-2904	153	8	transporters	transporter	NOUN
ijpds-2904	153	9	in	in	ADP
ijpds-2904	153	10	the	the	DET
ijpds-2904	153	11	distribution	distribution	NOUN
ijpds-2904	153	12	of	of	ADP
ijpds-2904	153	13	platinum	platinum	NOUN
ijpds-2904	153	14	-	-	PUNCT
ijpds-2904	153	15	based	base	VERB
ijpds-2904	153	16	drugs	drug	NOUN
ijpds-2904	153	17	.	.	PUNCT
ijpds-2904	154	1	front	front	ADJ
ijpds-2904	154	2	pharmacol	pharmacol	PROPN
ijpds-2904	154	3	.	.	PUNCT
ijpds-2904	155	1	2015	2015	NUM
ijpds-2904	155	2	,	,	PUNCT
ijpds-2904	155	3	6:1–8	6:1–8	NUM
ijpds-2904	155	4	.	.	PUNCT
ijpds-2904	155	5	10.3389	10.3389	NUM
ijpds-2904	155	6	/	/	SYM
ijpds-2904	155	7	fphar.2015.00085	fphar.2015.00085	PROPN
ijpds-2904	155	8	11	11	NUM
ijpds-2904	155	9	.	.	PUNCT
ijpds-2904	156	1	monneret	monneret	PROPN
ijpds-2904	156	2	c.	c.	PROPN
ijpds-2904	156	3	platinum	platinum	NOUN
ijpds-2904	156	4	anticancer	anticancer	NOUN
ijpds-2904	156	5	drugs	drug	NOUN
ijpds-2904	156	6	.	.	PUNCT
ijpds-2904	157	1	from	from	ADP
ijpds-2904	157	2	serendipity	serendipity	NOUN
ijpds-2904	157	3	to	to	ADP
ijpds-2904	157	4	rational	rational	ADJ
ijpds-2904	157	5	design	design	NOUN
ijpds-2904	157	6	.	.	PUNCT
ijpds-2904	158	1	in	in	ADP
ijpds-2904	158	2	:	:	PUNCT
ijpds-2904	158	3	annales	annale	NOUN
ijpds-2904	158	4	pharmaceutiques	pharmaceutique	NOUN
ijpds-2904	158	5	francaises	francaise	NOUN
ijpds-2904	158	6	.	.	PUNCT
ijpds-2904	159	1	elsevier	elsevier	NOUN
ijpds-2904	159	2	;	;	PUNCT
ijpds-2904	159	3	2011	2011	NUM
ijpds-2904	159	4	.	.	PUNCT
ijpds-2904	160	1	286–95	286–95	NUM
ijpds-2904	160	2	.	.	PUNCT
ijpds-2904	161	1	12	12	NUM
ijpds-2904	161	2	.	.	PUNCT
ijpds-2904	162	1	ciarimboli	ciarimboli	NOUN
ijpds-2904	162	2	g.	g.	PROPN
ijpds-2904	162	3	membrane	membrane	NOUN
ijpds-2904	162	4	transporters	transporter	NOUN
ijpds-2904	162	5	as	as	ADP
ijpds-2904	162	6	mediators	mediator	NOUN
ijpds-2904	162	7	of	of	ADP
ijpds-2904	162	8	cisplatin	cisplatin	NOUN
ijpds-2904	162	9	effects	effect	NOUN
ijpds-2904	162	10	and	and	CCONJ
ijpds-2904	162	11	side	side	NOUN
ijpds-2904	162	12	effects	effect	NOUN
ijpds-2904	162	13	.	.	PUNCT
ijpds-2904	163	1	scientifica	scientifica	PROPN
ijpds-2904	163	2	(	(	PUNCT
ijpds-2904	163	3	cairo	cairo	PROPN
ijpds-2904	163	4	)	)	PUNCT
ijpds-2904	163	5	.	.	PUNCT
ijpds-2904	164	1	2012	2012	NUM
ijpds-2904	164	2	,	,	PUNCT
ijpds-2904	164	3	2012	2012	NUM
ijpds-2904	164	4	:	:	PUNCT
ijpds-2904	164	5	63	63	NUM
ijpds-2904	164	6	-	-	SYM
ijpds-2904	164	7	67	67	NUM
ijpds-2904	164	8	.	.	PUNCT
ijpds-2904	165	1	13	13	NUM
ijpds-2904	165	2	.	.	PUNCT
ijpds-2904	166	1	abumrad	abumrad	PROPN
ijpds-2904	166	2	n	n	PROPN
ijpds-2904	166	3	,	,	PUNCT
ijpds-2904	166	4	harmon	harmon	PROPN
ijpds-2904	166	5	c	c	PROPN
ijpds-2904	166	6	,	,	PUNCT
ijpds-2904	166	7	ibrahimi	ibrahimi	PROPN
ijpds-2904	166	8	a.	a.	NOUN
ijpds-2904	166	9	membrane	membrane	NOUN
ijpds-2904	166	10	transport	transport	NOUN
ijpds-2904	166	11	of	of	ADP
ijpds-2904	166	12	longchain	longchain	NOUN
ijpds-2904	166	13	fatty	fatty	NOUN
ijpds-2904	166	14	acids	acid	NOUN
ijpds-2904	166	15	:	:	PUNCT
ijpds-2904	166	16	evidence	evidence	NOUN
ijpds-2904	166	17	for	for	ADP
ijpds-2904	166	18	a	a	DET
ijpds-2904	166	19	facilitated	facilitate	VERB
ijpds-2904	166	20	process	process	NOUN
ijpds-2904	166	21	.	.	PUNCT
ijpds-2904	167	1	j	j	PROPN
ijpds-2904	167	2	lipid	lipid	PROPN
ijpds-2904	167	3	res	re	NOUN
ijpds-2904	167	4	.	.	PUNCT
ijpds-2904	168	1	1998	1998	NUM
ijpds-2904	168	2	,	,	PUNCT
ijpds-2904	168	3	39:2309–18	39:2309–18	NUM
ijpds-2904	168	4	.	.	PUNCT
ijpds-2904	169	1	14	14	NUM
ijpds-2904	169	2	.	.	PUNCT
ijpds-2904	170	1	farrell	farrell	PROPN
ijpds-2904	170	2	np	np	PROPN
ijpds-2904	170	3	.	.	PUNCT
ijpds-2904	170	4	multi	multi	ADJ
ijpds-2904	170	5	-	-	ADJ
ijpds-2904	170	6	platinum	platinum	ADJ
ijpds-2904	170	7	anti	anti	ADJ
ijpds-2904	170	8	-	-	ADJ
ijpds-2904	170	9	cancer	cancer	ADJ
ijpds-2904	170	10	agents	agent	NOUN
ijpds-2904	170	11	.	.	PUNCT
ijpds-2904	171	1	substitution	substitution	NOUN
ijpds-2904	171	2	-	-	PUNCT
ijpds-2904	171	3	inert	inert	NOUN
ijpds-2904	171	4	compounds	compound	NOUN
ijpds-2904	171	5	for	for	ADP
ijpds-2904	171	6	tumor	tumor	NOUN
ijpds-2904	171	7	selectivity	selectivity	NOUN
ijpds-2904	171	8	and	and	CCONJ
ijpds-2904	171	9	new	new	ADJ
ijpds-2904	171	10	targets	target	NOUN
ijpds-2904	171	11	.	.	PUNCT
ijpds-2904	172	1	chem	chem	NOUN
ijpds-2904	172	2	soc	soc	NOUN
ijpds-2904	172	3	rev	rev	VERB
ijpds-2904	172	4	.	.	PROPN
ijpds-2904	172	5	2015	2015	NUM
ijpds-2904	172	6	,	,	PUNCT
ijpds-2904	172	7	44:8773–85	44:8773–85	NUM
ijpds-2904	172	8	.	.	PUNCT
ijpds-2904	173	1	15	15	NUM
ijpds-2904	173	2	.	.	PUNCT
ijpds-2904	174	1	mezencev	mezencev	PROPN
ijpds-2904	174	2	r.	r.	PROPN
ijpds-2904	174	3	interactions	interaction	NOUN
ijpds-2904	174	4	of	of	ADP
ijpds-2904	174	5	cisplatin	cisplatin	NOUN
ijpds-2904	174	6	with	with	ADP
ijpds-2904	174	7	non	non	ADJ
ijpds-2904	174	8	-	-	ADJ
ijpds-2904	174	9	dna	dna	ADJ
ijpds-2904	174	10	targets	target	NOUN
ijpds-2904	174	11	and	and	CCONJ
ijpds-2904	174	12	their	their	PRON
ijpds-2904	174	13	influence	influence	NOUN
ijpds-2904	174	14	on	on	ADP
ijpds-2904	174	15	anticancer	anticancer	NOUN
ijpds-2904	174	16	activity	activity	NOUN
ijpds-2904	174	17	and	and	CCONJ
ijpds-2904	174	18	drug	drug	NOUN
ijpds-2904	174	19	toxicity	toxicity	NOUN
ijpds-2904	174	20	:	:	PUNCT
ijpds-2904	174	21	the	the	DET
ijpds-2904	174	22	complex	complex	ADJ
ijpds-2904	174	23	world	world	NOUN
ijpds-2904	174	24	of	of	ADP
ijpds-2904	174	25	the	the	DET
ijpds-2904	174	26	platinum	platinum	NOUN
ijpds-2904	174	27	complex	complex	NOUN
ijpds-2904	174	28	.	.	PUNCT
ijpds-2904	175	1	curr	curr	PROPN
ijpds-2904	175	2	cancer	cancer	NOUN
ijpds-2904	175	3	drug	drug	NOUN
ijpds-2904	175	4	targets	target	NOUN
ijpds-2904	175	5	.	.	PUNCT
ijpds-2904	176	1	2014	2014	NUM
ijpds-2904	176	2	,	,	PUNCT
ijpds-2904	176	3	14:794–816	14:794–816	NUM
ijpds-2904	176	4	.	.	PUNCT
ijpds-2904	177	1	16	16	NUM
ijpds-2904	177	2	.	.	PUNCT
ijpds-2904	178	1	woods	woods	PROPN
ijpds-2904	178	2	d	d	X
ijpds-2904	178	3	,	,	PUNCT
ijpds-2904	178	4	turchi	turchi	PROPN
ijpds-2904	178	5	jj	jj	PROPN
ijpds-2904	178	6	.	.	PROPN
ijpds-2904	178	7	chemotherapy	chemotherapy	NOUN
ijpds-2904	178	8	induced	induce	VERB
ijpds-2904	178	9	dna	dna	PROPN
ijpds-2904	178	10	damage	damage	NOUN
ijpds-2904	178	11	response	response	NOUN
ijpds-2904	178	12	:	:	PUNCT
ijpds-2904	178	13	convergence	convergence	NOUN
ijpds-2904	178	14	of	of	ADP
ijpds-2904	178	15	drugs	drug	NOUN
ijpds-2904	178	16	and	and	CCONJ
ijpds-2904	178	17	pathways	pathway	NOUN
ijpds-2904	178	18	.	.	PUNCT
ijpds-2904	179	1	cancer	cancer	NOUN
ijpds-2904	179	2	biol	biol	PROPN
ijpds-2904	179	3	ther	ther	ADV
ijpds-2904	179	4	.	.	PUNCT
ijpds-2904	180	1	2013	2013	NUM
ijpds-2904	180	2	,	,	PUNCT
ijpds-2904	180	3	14:379–89	14:379–89	NUM
ijpds-2904	180	4	.	.	PUNCT
ijpds-2904	181	1	17	17	NUM
ijpds-2904	181	2	.	.	PUNCT
ijpds-2904	181	3	perazella	perazella	PROPN
ijpds-2904	181	4	ma	ma	PROPN
ijpds-2904	181	5	,	,	PUNCT
ijpds-2904	181	6	moeckel	moeckel	NOUN
ijpds-2904	181	7	gw	gw	PROPN
ijpds-2904	181	8	.	.	PUNCT
ijpds-2904	181	9	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	181	10	from	from	ADP
ijpds-2904	181	11	chemotherapeutic	chemotherapeutic	ADJ
ijpds-2904	181	12	agents	agent	NOUN
ijpds-2904	181	13	:	:	PUNCT
ijpds-2904	181	14	clinical	clinical	ADJ
ijpds-2904	181	15	manifestations	manifestation	NOUN
ijpds-2904	181	16	,	,	PUNCT
ijpds-2904	181	17	pathobiology	pathobiology	NOUN
ijpds-2904	181	18	,	,	PUNCT
ijpds-2904	181	19	and	and	CCONJ
ijpds-2904	181	20	prevention	prevention	NOUN
ijpds-2904	181	21	/	/	SYM
ijpds-2904	181	22	therapy	therapy	NOUN
ijpds-2904	181	23	.	.	PUNCT
ijpds-2904	182	1	in	in	ADP
ijpds-2904	182	2	:	:	PUNCT
ijpds-2904	182	3	seminars	seminar	NOUN
ijpds-2904	182	4	in	in	ADP
ijpds-2904	182	5	nephrology	nephrology	NOUN
ijpds-2904	182	6	.	.	PUNCT
ijpds-2904	183	1	elsevier	elsevier	NOUN
ijpds-2904	183	2	;	;	PUNCT
ijpds-2904	183	3	2010	2010	NUM
ijpds-2904	183	4	.	.	PUNCT
ijpds-2904	184	1	570–81	570–81	NUM
ijpds-2904	184	2	.	.	PUNCT
ijpds-2904	185	1	18	18	NUM
ijpds-2904	185	2	.	.	PUNCT
ijpds-2904	185	3	yao	yao	PROPN
ijpds-2904	185	4	x	x	PRON
ijpds-2904	185	5	,	,	PUNCT
ijpds-2904	185	6	panichpisal	panichpisal	PROPN
ijpds-2904	185	7	k	k	PROPN
ijpds-2904	185	8	,	,	PUNCT
ijpds-2904	185	9	kurtzman	kurtzman	PROPN
ijpds-2904	185	10	n	n	CCONJ
ijpds-2904	185	11	,	,	PUNCT
ijpds-2904	185	12	et	et	PROPN
ijpds-2904	185	13	al	al	PROPN
ijpds-2904	185	14	.	.	PROPN
ijpds-2904	185	15	cisplatin	cisplatin	PROPN
ijpds-2904	185	16	nephrotoxicity	nephrotoxicity	PROPN
ijpds-2904	185	17	:	:	PUNCT
ijpds-2904	185	18	a	a	DET
ijpds-2904	185	19	review	review	NOUN
ijpds-2904	185	20	.	.	PUNCT
ijpds-2904	186	1	am	be	AUX
ijpds-2904	186	2	j	j	PROPN
ijpds-2904	186	3	med	med	PROPN
ijpds-2904	186	4	sci	sci	PROPN
ijpds-2904	186	5	.	.	PROPN
ijpds-2904	186	6	2007	2007	NUM
ijpds-2904	186	7	,	,	PUNCT
ijpds-2904	187	1	334:115–24	334:115–24	NUM
ijpds-2904	187	2	.	.	PUNCT
ijpds-2904	188	1	19	19	NUM
ijpds-2904	188	2	.	.	X
ijpds-2904	189	1	bokemeyer	bokemeyer	PROPN
ijpds-2904	189	2	c	c	PROPN
ijpds-2904	189	3	,	,	PUNCT
ijpds-2904	189	4	berger	berger	PROPN
ijpds-2904	189	5	cc	cc	PROPN
ijpds-2904	189	6	,	,	PUNCT
ijpds-2904	189	7	hartmann	hartmann	PROPN
ijpds-2904	189	8	jt	jt	PROPN
ijpds-2904	189	9	,	,	PUNCT
ijpds-2904	189	10	et	et	PROPN
ijpds-2904	189	11	al	al	PROPN
ijpds-2904	189	12	.	.	PUNCT
ijpds-2904	190	1	analysis	analysis	NOUN
ijpds-2904	190	2	of	of	ADP
ijpds-2904	190	3	risk	risk	NOUN
ijpds-2904	190	4	factors	factor	NOUN
ijpds-2904	190	5	for	for	ADP
ijpds-2904	190	6	cisplatin	cisplatin	NOUN
ijpds-2904	190	7	-	-	PUNCT
ijpds-2904	190	8	induced	induce	VERB
ijpds-2904	190	9	ototoxicity	ototoxicity	NOUN
ijpds-2904	190	10	in	in	ADP
ijpds-2904	190	11	patients	patient	NOUN
ijpds-2904	190	12	with	with	ADP
ijpds-2904	190	13	testicular	testicular	ADJ
ijpds-2904	190	14	cancer	cancer	NOUN
ijpds-2904	190	15	.	.	PUNCT
ijpds-2904	191	1	br	br	PROPN
ijpds-2904	191	2	j	j	PROPN
ijpds-2904	191	3	cancer	cancer	NOUN
ijpds-2904	191	4	.	.	PUNCT
ijpds-2904	192	1	1998	1998	NUM
ijpds-2904	192	2	,	,	PUNCT
ijpds-2904	192	3	77:1355	77:1355	NUM
ijpds-2904	192	4	.	.	NOUN
ijpds-2904	192	5	20	20	NUM
ijpds-2904	192	6	.	.	PUNCT
ijpds-2904	193	1	ciarimboli	ciarimboli	NOUN
ijpds-2904	193	2	g	g	PROPN
ijpds-2904	193	3	,	,	PUNCT
ijpds-2904	193	4	deuster	deuster	NOUN
ijpds-2904	193	5	d	d	PROPN
ijpds-2904	193	6	,	,	PUNCT
ijpds-2904	193	7	knief	knief	PROPN
ijpds-2904	193	8	a	a	X
ijpds-2904	193	9	,	,	PUNCT
ijpds-2904	193	10	et	et	PROPN
ijpds-2904	193	11	al	al	PROPN
ijpds-2904	193	12	.	.	PROPN
ijpds-2904	193	13	:	:	PUNCT
ijpds-2904	194	1	organic	organic	ADJ
ijpds-2904	194	2	cation	cation	NOUN
ijpds-2904	194	3	transporter	transporter	NOUN
ijpds-2904	194	4	2	2	NUM
ijpds-2904	194	5	mediates	mediate	NOUN
ijpds-2904	194	6	cisplatin	cisplatin	NOUN
ijpds-2904	194	7	-	-	PUNCT
ijpds-2904	194	8	induced	induce	VERB
ijpds-2904	194	9	oto	oto	NOUN
ijpds-2904	194	10	-	-	PUNCT
ijpds-2904	194	11	and	and	CCONJ
ijpds-2904	194	12	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	194	13	and	and	CCONJ
ijpds-2904	194	14	is	be	AUX
ijpds-2904	194	15	a	a	DET
ijpds-2904	194	16	target	target	NOUN
ijpds-2904	194	17	for	for	ADP
ijpds-2904	194	18	protective	protective	ADJ
ijpds-2904	194	19	interventions	intervention	NOUN
ijpds-2904	194	20	.	.	PUNCT
ijpds-2904	195	1	am	be	AUX
ijpds-2904	195	2	j	j	PROPN
ijpds-2904	195	3	pathol	pathol	NOUN
ijpds-2904	195	4	.	.	PUNCT
ijpds-2904	196	1	2010	2010	NUM
ijpds-2904	196	2	,	,	PUNCT
ijpds-2904	196	3	176:1169–80	176:1169–80	PROPN
ijpds-2904	196	4	.	.	PROPN
ijpds-2904	196	5	21	21	NUM
ijpds-2904	196	6	.	.	PUNCT
ijpds-2904	197	1	langer	langer	PROPN
ijpds-2904	197	2	t	t	PROPN
ijpds-2904	197	3	,	,	PUNCT
ijpds-2904	197	4	am	be	AUX
ijpds-2904	197	5	zehnhoff	zehnhoff	NOUN
ijpds-2904	197	6	-	-	PUNCT
ijpds-2904	197	7	dinnesen	dinnesen	PROPN
ijpds-2904	197	8	a	a	PRON
ijpds-2904	197	9	,	,	PUNCT
ijpds-2904	197	10	radtke	radtke	ADJ
ijpds-2904	197	11	s	s	PROPN
ijpds-2904	197	12	,	,	PUNCT
ijpds-2904	197	13	et	et	PROPN
ijpds-2904	197	14	al	al	PROPN
ijpds-2904	197	15	.	.	PUNCT
ijpds-2904	198	1	understanding	understand	VERB
ijpds-2904	198	2	platinum	platinum	NOUN
ijpds-2904	198	3	-	-	PUNCT
ijpds-2904	198	4	induced	induce	VERB
ijpds-2904	198	5	ototoxicity	ototoxicity	NOUN
ijpds-2904	198	6	.	.	PUNCT
ijpds-2904	199	1	trends	trend	NOUN
ijpds-2904	199	2	pharmacol	pharmacol	PROPN
ijpds-2904	199	3	sci	sci	PROPN
ijpds-2904	199	4	.	.	PROPN
ijpds-2904	199	5	2013	2013	NUM
ijpds-2904	199	6	,	,	PUNCT
ijpds-2904	199	7	34:458–69	34:458–69	NUM
ijpds-2904	199	8	.	.	PUNCT
ijpds-2904	200	1	22	22	NUM
ijpds-2904	200	2	.	.	PUNCT
ijpds-2904	201	1	sheth	sheth	PROPN
ijpds-2904	201	2	s	s	PROPN
ijpds-2904	201	3	,	,	PUNCT
ijpds-2904	201	4	mukherjea	mukherjea	PROPN
ijpds-2904	201	5	d	d	PROPN
ijpds-2904	201	6	,	,	PUNCT
ijpds-2904	201	7	rybak	rybak	PROPN
ijpds-2904	201	8	lp	lp	PROPN
ijpds-2904	201	9	,	,	PUNCT
ijpds-2904	201	10	et	et	PROPN
ijpds-2904	201	11	al	al	PROPN
ijpds-2904	201	12	.	.	PROPN
ijpds-2904	201	13	mechanisms	mechanism	NOUN
ijpds-2904	201	14	of	of	ADP
ijpds-2904	201	15	cisplatininduced	cisplatininduced	ADJ
ijpds-2904	201	16	ototoxicity	ototoxicity	NOUN
ijpds-2904	201	17	and	and	CCONJ
ijpds-2904	201	18	otoprotection	otoprotection	NOUN
ijpds-2904	201	19	.	.	PUNCT
ijpds-2904	202	1	front	front	ADJ
ijpds-2904	202	2	cell	cell	NOUN
ijpds-2904	202	3	neurosci	neurosci	NOUN
ijpds-2904	202	4	.	.	PUNCT
ijpds-2904	203	1	2017	2017	NUM
ijpds-2904	203	2	,	,	PUNCT
ijpds-2904	203	3	11:338	11:338	NUM
ijpds-2904	203	4	.	.	PUNCT
ijpds-2904	204	1	23	23	NUM
ijpds-2904	204	2	.	.	PUNCT
ijpds-2904	205	1	mclaren	mclaren	PROPN
ijpds-2904	205	2	n.	n.	PROPN
ijpds-2904	205	3	an	an	DET
ijpds-2904	205	4	investigation	investigation	NOUN
ijpds-2904	205	5	into	into	ADP
ijpds-2904	205	6	normative	normative	ADJ
ijpds-2904	205	7	responses	response	NOUN
ijpds-2904	205	8	for	for	ADP
ijpds-2904	205	9	the	the	DET
ijpds-2904	205	10	upper	upper	ADJ
ijpds-2904	205	11	limb	limb	NOUN
ijpds-2904	205	12	neurodynamic	neurodynamic	ADJ
ijpds-2904	205	13	test	test	NOUN
ijpds-2904	205	14	with	with	ADP
ijpds-2904	205	15	radial	radial	ADJ
ijpds-2904	205	16	nerve	nerve	NOUN
ijpds-2904	205	17	bias	bias	NOUN
ijpds-2904	205	18	.	.	PUNCT
ijpds-2904	206	1	2013	2013	NUM
ijpds-2904	206	2	:	:	PUNCT
ijpds-2904	206	3	34453	34453	NUM
ijpds-2904	206	4	.	.	PUNCT
ijpds-2904	207	1	24	24	NUM
ijpds-2904	207	2	.	.	X
ijpds-2904	207	3	delforge	delforge	PROPN
ijpds-2904	207	4	m	m	PROPN
ijpds-2904	207	5	,	,	PUNCT
ijpds-2904	207	6	bladé	bladé	PROPN
ijpds-2904	207	7	j	j	PROPN
ijpds-2904	207	8	,	,	PUNCT
ijpds-2904	207	9	dimopoulos	dimopoulos	PROPN
ijpds-2904	207	10	ma	ma	PROPN
ijpds-2904	207	11	,	,	PUNCT
ijpds-2904	207	12	et	et	PROPN
ijpds-2904	207	13	al	al	PROPN
ijpds-2904	207	14	.	.	PUNCT
ijpds-2904	207	15	treatment	treatment	NOUN
ijpds-2904	207	16	-	-	PUNCT
ijpds-2904	207	17	related	relate	VERB
ijpds-2904	207	18	peripheral	peripheral	ADJ
ijpds-2904	207	19	neuropathy	neuropathy	ADJ
ijpds-2904	207	20	in	in	ADP
ijpds-2904	207	21	multiple	multiple	ADJ
ijpds-2904	207	22	myeloma	myeloma	NOUN
ijpds-2904	207	23	:	:	PUNCT
ijpds-2904	207	24	the	the	DET
ijpds-2904	207	25	challenge	challenge	NOUN
ijpds-2904	207	26	continues	continue	VERB
ijpds-2904	207	27	.	.	PUNCT
ijpds-2904	208	1	lancet	lancet	PROPN
ijpds-2904	208	2	oncol	oncol	PROPN
ijpds-2904	208	3	.	.	PUNCT
ijpds-2904	209	1	2010	2010	NUM
ijpds-2904	209	2	,	,	PUNCT
ijpds-2904	209	3	11:1086–95	11:1086–95	NUM
ijpds-2904	209	4	.	.	PUNCT
ijpds-2904	210	1	25	25	NUM
ijpds-2904	210	2	.	.	NOUN
ijpds-2904	210	3	quasthoff	quasthoff	PROPN
ijpds-2904	210	4	s	s	PROPN
ijpds-2904	210	5	,	,	PUNCT
ijpds-2904	210	6	hartung	hartung	PROPN
ijpds-2904	210	7	hp	hp	PROPN
ijpds-2904	210	8	:	:	PUNCT
ijpds-2904	210	9	chemotherapy	chemotherapy	NOUN
ijpds-2904	210	10	-	-	ADJ
ijpds-2904	210	11	induced	induce	VERB
ijpds-2904	210	12	peripheral	peripheral	ADJ
ijpds-2904	210	13	neuropathy	neuropathy	ADJ
ijpds-2904	210	14	.	.	PUNCT
ijpds-2904	211	1	j	j	PROPN
ijpds-2904	211	2	neurol	neurol	PROPN
ijpds-2904	211	3	.	.	PUNCT
ijpds-2904	212	1	2002	2002	NUM
ijpds-2904	212	2	,	,	PUNCT
ijpds-2904	212	3	249:9–17	249:9–17	NUM
ijpds-2904	212	4	.	.	NOUN
ijpds-2904	212	5	26	26	NUM
ijpds-2904	212	6	.	.	PUNCT
ijpds-2904	213	1	harrach	harrach	PROPN
ijpds-2904	213	2	s	s	SYM
ijpds-2904	213	3	,	,	PUNCT
ijpds-2904	213	4	ciarimboli	ciarimboli	NOUN
ijpds-2904	213	5	g.	g.	NOUN
ijpds-2904	213	6	role	role	NOUN
ijpds-2904	213	7	of	of	ADP
ijpds-2904	213	8	transporters	transporter	NOUN
ijpds-2904	213	9	in	in	ADP
ijpds-2904	213	10	the	the	DET
ijpds-2904	213	11	distribution	distribution	NOUN
ijpds-2904	213	12	of	of	ADP
ijpds-2904	213	13	platinum	platinum	NOUN
ijpds-2904	213	14	-	-	PUNCT
ijpds-2904	213	15	based	base	VERB
ijpds-2904	213	16	drugs	drug	NOUN
ijpds-2904	213	17	.	.	PUNCT
ijpds-2904	214	1	front	front	ADJ
ijpds-2904	214	2	pharmacol	pharmacol	PROPN
ijpds-2904	214	3	.	.	PUNCT
ijpds-2904	215	1	2015	2015	NUM
ijpds-2904	215	2	;	;	PUNCT
ijpds-2904	215	3	6:85	6:85	NUM
ijpds-2904	215	4	-	-	SYM
ijpds-2904	215	5	95	95	NUM
ijpds-2904	215	6	.	.	PUNCT
ijpds-2904	216	1	27	27	NUM
ijpds-2904	216	2	.	.	X
ijpds-2904	217	1	perde	perde	PROPN
ijpds-2904	217	2	-	-	PUNCT
ijpds-2904	217	3	schrepler	schrepler	PROPN
ijpds-2904	217	4	m	m	PROPN
ijpds-2904	217	5	,	,	PUNCT
ijpds-2904	217	6	fischer	fischer	PROPN
ijpds-2904	217	7	-	-	PUNCT
ijpds-2904	217	8	fodor	fodor	PROPN
ijpds-2904	217	9	e	e	PROPN
ijpds-2904	217	10	,	,	PUNCT
ijpds-2904	217	11	virag	virag	NOUN
ijpds-2904	217	12	p	p	NOUN
ijpds-2904	217	13	,	,	PUNCT
ijpds-2904	217	14	et	et	PROPN
ijpds-2904	217	15	al	al	PROPN
ijpds-2904	217	16	.	.	PUNCT
ijpds-2904	218	1	the	the	DET
ijpds-2904	218	2	expression	expression	NOUN
ijpds-2904	218	3	of	of	ADP
ijpds-2904	218	4	copper	copper	NOUN
ijpds-2904	218	5	transporters	transporter	NOUN
ijpds-2904	218	6	associated	associate	VERB
ijpds-2904	218	7	with	with	ADP
ijpds-2904	218	8	the	the	DET
ijpds-2904	218	9	ototoxicity	ototoxicity	NOUN
ijpds-2904	218	10	induced	induce	VERB
ijpds-2904	218	11	by	by	ADP
ijpds-2904	218	12	platinum	platinum	NOUN
ijpds-2904	218	13	-	-	PUNCT
ijpds-2904	218	14	based	base	VERB
ijpds-2904	218	15	chemotherapeutic	chemotherapeutic	ADJ
ijpds-2904	218	16	agents	agent	NOUN
ijpds-2904	218	17	.	.	PUNCT
ijpds-2904	219	1	hear	hear	VERB
ijpds-2904	219	2	res	re	NOUN
ijpds-2904	219	3	.	.	PUNCT
ijpds-2904	220	1	2020	2020	NUM
ijpds-2904	220	2	,	,	PUNCT
ijpds-2904	220	3	388:107893	388:107893	NUM
ijpds-2904	220	4	.	.	NOUN
ijpds-2904	220	5	28	28	NUM
ijpds-2904	220	6	.	.	PUNCT
ijpds-2904	221	1	katano	katano	PROPN
ijpds-2904	221	2	k	k	PROPN
ijpds-2904	221	3	,	,	PUNCT
ijpds-2904	221	4	kondo	kondo	PROPN
ijpds-2904	221	5	a	a	X
ijpds-2904	221	6	,	,	PUNCT
ijpds-2904	221	7	safaei	safaei	NOUN
ijpds-2904	221	8	r	r	NOUN
ijpds-2904	221	9	,	,	PUNCT
ijpds-2904	221	10	et	et	PROPN
ijpds-2904	221	11	al	al	PROPN
ijpds-2904	221	12	.	.	PROPN
ijpds-2904	221	13	acquisition	acquisition	NOUN
ijpds-2904	221	14	of	of	ADP
ijpds-2904	221	15	resistance	resistance	NOUN
ijpds-2904	221	16	to	to	ADP
ijpds-2904	221	17	cisplatin	cisplatin	NOUN
ijpds-2904	221	18	is	be	AUX
ijpds-2904	221	19	accompanied	accompany	VERB
ijpds-2904	221	20	by	by	ADP
ijpds-2904	221	21	changes	change	NOUN
ijpds-2904	221	22	in	in	ADP
ijpds-2904	221	23	the	the	DET
ijpds-2904	221	24	cellular	cellular	ADJ
ijpds-2904	221	25	pharmacology	pharmacology	NOUN
ijpds-2904	221	26	sakshi	sakshi	PROPN
ijpds-2904	221	27	and	and	CCONJ
ijpds-2904	221	28	singh	singh	PROPN
ijpds-2904	221	29	cisplatin	cisplatin	NOUN
ijpds-2904	221	30	induced	induce	VERB
ijpds-2904	221	31	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	221	32	vol	vol	NOUN
ijpds-2904	221	33	1	1	NUM
ijpds-2904	221	34	|	|	NOUN
ijpds-2904	221	35	issue	issue	VERB
ijpds-2904	221	36	1	1	NUM
ijpds-2904	221	37	|	|	ADV
ijpds-2904	221	38	apr	apr	ADV
ijpds-2904	221	39	–	–	PUNCT
ijpds-2904	221	40	jun	jun	PROPN
ijpds-2904	221	41	2022	2022	NUM
ijpds-2904	221	42	indian	indian	PROPN
ijpds-2904	221	43	j	j	PROPN
ijpds-2904	221	44	pharm	pharm	PROPN
ijpds-2904	221	45	drug	drug	PROPN
ijpds-2904	221	46	studies	study	NOUN
ijpds-2904	221	47	|	|	ADV
ijpds-2904	221	48	9	9	NUM
ijpds-2904	221	49	of	of	ADP
ijpds-2904	221	50	copper	copper	NOUN
ijpds-2904	221	51	.	.	PUNCT
ijpds-2904	222	1	cancer	cancer	NOUN
ijpds-2904	222	2	res	re	NOUN
ijpds-2904	222	3	.	.	PUNCT
ijpds-2904	223	1	2002	2002	NUM
ijpds-2904	223	2	,	,	PUNCT
ijpds-2904	223	3	62:6559–65	62:6559–65	NUM
ijpds-2904	223	4	.	.	PROPN
ijpds-2904	224	1	29	29	NUM
ijpds-2904	224	2	.	.	PUNCT
ijpds-2904	225	1	skvortsov	skvortsov	PROPN
ijpds-2904	225	2	an	an	PROPN
ijpds-2904	225	3	,	,	PUNCT
ijpds-2904	225	4	zatulovskiy	zatulovskiy	PROPN
ijpds-2904	225	5	ea	ea	PROPN
ijpds-2904	225	6	,	,	PUNCT
ijpds-2904	225	7	puchkova	puchkova	PROPN
ijpds-2904	225	8	lv	lv	PROPN
ijpds-2904	225	9	.	.	PUNCT
ijpds-2904	225	10	structurefunctional	structurefunctional	ADJ
ijpds-2904	225	11	organization	organization	NOUN
ijpds-2904	225	12	of	of	ADP
ijpds-2904	225	13	eukaryotic	eukaryotic	ADJ
ijpds-2904	225	14	high	high	ADJ
ijpds-2904	225	15	-	-	PUNCT
ijpds-2904	225	16	affinity	affinity	NOUN
ijpds-2904	225	17	copper	copper	NOUN
ijpds-2904	225	18	importer	importer	NOUN
ijpds-2904	225	19	ctr1	ctr1	PROPN
ijpds-2904	225	20	determines	determine	VERB
ijpds-2904	225	21	its	its	PRON
ijpds-2904	225	22	ability	ability	NOUN
ijpds-2904	225	23	to	to	PART
ijpds-2904	225	24	transport	transport	VERB
ijpds-2904	225	25	copper	copper	NOUN
ijpds-2904	225	26	,	,	PUNCT
ijpds-2904	225	27	silver	silver	NOUN
ijpds-2904	225	28	,	,	PUNCT
ijpds-2904	225	29	and	and	CCONJ
ijpds-2904	225	30	cisplatin	cisplatin	NOUN
ijpds-2904	225	31	.	.	PUNCT
ijpds-2904	226	1	mol	mol	ADP
ijpds-2904	226	2	biol	biol	PROPN
ijpds-2904	226	3	.	.	PUNCT
ijpds-2904	227	1	2012	2012	NUM
ijpds-2904	227	2	,	,	PUNCT
ijpds-2904	227	3	46:304–15	46:304–15	NUM
ijpds-2904	227	4	.	.	PUNCT
ijpds-2904	228	1	30	30	NUM
ijpds-2904	228	2	.	.	PUNCT
ijpds-2904	229	1	blair	blair	PROPN
ijpds-2904	229	2	bg	bg	PROPN
ijpds-2904	229	3	,	,	PUNCT
ijpds-2904	229	4	larson	larson	PROPN
ijpds-2904	229	5	ca	can	AUX
ijpds-2904	229	6	,	,	PUNCT
ijpds-2904	229	7	safaei	safaei	VERB
ijpds-2904	229	8	r	r	NOUN
ijpds-2904	229	9	,	,	PUNCT
ijpds-2904	229	10	et	et	PROPN
ijpds-2904	229	11	al	al	PROPN
ijpds-2904	229	12	.	.	PUNCT
ijpds-2904	229	13	copper	copper	NOUN
ijpds-2904	229	14	transporter	transporter	NOUN
ijpds-2904	229	15	2	2	NUM
ijpds-2904	229	16	regulates	regulate	VERB
ijpds-2904	229	17	cellular	cellular	ADJ
ijpds-2904	229	18	accumulation	accumulation	NOUN
ijpds-2904	229	19	and	and	CCONJ
ijpds-2904	229	20	cytotoxicity	cytotoxicity	NOUN
ijpds-2904	229	21	of	of	ADP
ijpds-2904	229	22	cispla	cispla	ADJ
ijpds-2904	229	23	tin	tin	NOUN
ijpds-2904	229	24	and	and	CCONJ
ijpds-2904	229	25	carboplatin	carboplatin	NOUN
ijpds-2904	229	26	.	.	PUNCT
ijpds-2904	230	1	clin	clin	PROPN
ijpds-2904	230	2	cancer	cancer	NOUN
ijpds-2904	230	3	res	re	NOUN
ijpds-2904	230	4	.	.	PUNCT
ijpds-2904	230	5	2009	2009	NUM
ijpds-2904	230	6	,	,	PUNCT
ijpds-2904	230	7	15	15	NUM
ijpds-2904	230	8	:	:	SYM
ijpds-2904	230	9	4312	4312	NUM
ijpds-2904	230	10	–	–	PUNCT
ijpds-2904	230	11	21	21	NUM
ijpds-2904	230	12	.	.	PUNCT
ijpds-2904	231	1	31	31	NUM
ijpds-2904	231	2	.	.	PUNCT
ijpds-2904	232	1	ahmed	ahmed	PROPN
ijpds-2904	232	2	z	z	PROPN
ijpds-2904	232	3	,	,	PUNCT
ijpds-2904	232	4	deyama	deyama	PROPN
ijpds-2904	232	5	y	y	PROPN
ijpds-2904	232	6	,	,	PUNCT
ijpds-2904	232	7	yoshimura	yoshimura	NOUN
ijpds-2904	232	8	y	y	PROPN
ijpds-2904	232	9	,	,	PUNCT
ijpds-2904	232	10	et	et	PROPN
ijpds-2904	232	11	al	al	PROPN
ijpds-2904	232	12	.	.	PROPN
ijpds-2904	232	13	cisplatin	cisplatin	NOUN
ijpds-2904	232	14	sensitivity	sensitivity	NOUN
ijpds-2904	232	15	of	of	ADP
ijpds-2904	232	16	oral	oral	ADJ
ijpds-2904	232	17	squamous	squamous	ADJ
ijpds-2904	232	18	carcinoma	carcinoma	NOUN
ijpds-2904	232	19	cells	cell	NOUN
ijpds-2904	232	20	is	be	AUX
ijpds-2904	232	21	regulated	regulate	VERB
ijpds-2904	232	22	by	by	ADP
ijpds-2904	232	23	na+	na+	NOUN
ijpds-2904	232	24	,	,	PUNCT
ijpds-2904	232	25	k+	k+	PROPN
ijpds-2904	232	26	atpase	atpase	PROPN
ijpds-2904	232	27	activity	activity	NOUN
ijpds-2904	232	28	rather	rather	ADV
ijpds-2904	232	29	than	than	ADP
ijpds-2904	232	30	copper	copper	NOUN
ijpds-2904	232	31	-	-	PUNCT
ijpds-2904	232	32	transporting	transport	VERB
ijpds-2904	232	33	p	p	ADJ
ijpds-2904	232	34	-	-	PUNCT
ijpds-2904	232	35	type	type	NOUN
ijpds-2904	232	36	atpases	atpase	NOUN
ijpds-2904	232	37	,	,	PUNCT
ijpds-2904	232	38	atp7a	atp7a	PUNCT
ijpds-2904	232	39	and	and	CCONJ
ijpds-2904	232	40	atp7b	atp7b	PROPN
ijpds-2904	232	41	.	.	PUNCT
ijpds-2904	233	1	cancer	cancer	NOUN
ijpds-2904	233	2	chemother	chemother	PROPN
ijpds-2904	233	3	pharmacol	pharmacol	PROPN
ijpds-2904	233	4	.	.	PUNCT
ijpds-2904	234	1	2009	2009	NUM
ijpds-2904	234	2	,	,	PUNCT
ijpds-2904	234	3	63:643650	63:643650	PROPN
ijpds-2904	234	4	.	.	PUNCT
ijpds-2904	235	1	32	32	NUM
ijpds-2904	235	2	.	.	PUNCT
ijpds-2904	236	1	chen	chen	PROPN
ijpds-2904	236	2	hhw	hhw	PROPN
ijpds-2904	236	3	,	,	PUNCT
ijpds-2904	236	4	song	song	NOUN
ijpds-2904	236	5	i	i	PROPN
ijpds-2904	236	6	-	-	PUNCT
ijpds-2904	236	7	s	s	PROPN
ijpds-2904	236	8	,	,	PUNCT
ijpds-2904	236	9	hossain	hossain	PROPN
ijpds-2904	236	10	a	a	PROPN
ijpds-2904	236	11	,	,	PUNCT
ijpds-2904	236	12	et	et	PROPN
ijpds-2904	236	13	al	al	PROPN
ijpds-2904	236	14	.	.	PROPN
ijpds-2904	236	15	elevated	elevated	ADJ
ijpds-2904	236	16	glutathione	glutathione	NOUN
ijpds-2904	236	17	levels	level	NOUN
ijpds-2904	236	18	confer	confer	VERB
ijpds-2904	236	19	cellular	cellular	ADJ
ijpds-2904	236	20	sensitization	sensitization	NOUN
ijpds-2904	236	21	to	to	ADP
ijpds-2904	236	22	cisplatin	cisplatin	NOUN
ijpds-2904	236	23	toxicity	toxicity	NOUN
ijpds-2904	236	24	by	by	ADP
ijpds-2904	236	25	up	up	ADP
ijpds-2904	236	26	-	-	PUNCT
ijpds-2904	236	27	regulation	regulation	NOUN
ijpds-2904	236	28	of	of	ADP
ijpds-2904	236	29	copper	copper	NOUN
ijpds-2904	236	30	transporter	transporter	NOUN
ijpds-2904	236	31	hctr1	hctr1	PROPN
ijpds-2904	236	32	.	.	PUNCT
ijpds-2904	237	1	mol	mol	ADP
ijpds-2904	237	2	pharmacol	pharmacol	PROPN
ijpds-2904	237	3	.	.	PUNCT
ijpds-2904	237	4	2008	2008	NUM
ijpds-2904	237	5	,	,	PUNCT
ijpds-2904	238	1	74:697–704	74:697–704	NUM
ijpds-2904	238	2	.	.	PUNCT
ijpds-2904	239	1	33	33	NUM
ijpds-2904	239	2	.	.	PUNCT
ijpds-2904	240	1	lutsenko	lutsenko	PROPN
ijpds-2904	240	2	s	s	PROPN
ijpds-2904	240	3	,	,	PUNCT
ijpds-2904	240	4	barnes	barnes	PROPN
ijpds-2904	240	5	nl	nl	PROPN
ijpds-2904	240	6	,	,	PUNCT
ijpds-2904	240	7	bartee	bartee	VERB
ijpds-2904	240	8	my	my	PRON
ijpds-2904	240	9	,	,	PUNCT
ijpds-2904	240	10	et	et	PROPN
ijpds-2904	240	11	al	al	PROPN
ijpds-2904	240	12	.	.	PROPN
ijpds-2904	240	13	function	function	NOUN
ijpds-2904	240	14	and	and	CCONJ
ijpds-2904	240	15	regulation	regulation	NOUN
ijpds-2904	240	16	of	of	ADP
ijpds-2904	240	17	human	human	ADJ
ijpds-2904	240	18	copper	copper	NOUN
ijpds-2904	240	19	-	-	PUNCT
ijpds-2904	240	20	transporting	transport	VERB
ijpds-2904	240	21	atpases	atpase	NOUN
ijpds-2904	240	22	.	.	PUNCT
ijpds-2904	241	1	physiol	physiol	PROPN
ijpds-2904	241	2	rev	rev	VERB
ijpds-2904	241	3	.	.	PROPN
ijpds-2904	241	4	2007	2007	NUM
ijpds-2904	241	5	,	,	PUNCT
ijpds-2904	241	6	87:1011–46	87:1011–46	NUM
ijpds-2904	241	7	.	.	PUNCT
ijpds-2904	242	1	34	34	NUM
ijpds-2904	242	2	.	.	PUNCT
ijpds-2904	242	3	kalayda	kalayda	PROPN
ijpds-2904	242	4	g	g	PROPN
ijpds-2904	242	5	v	v	PROPN
ijpds-2904	242	6	,	,	PUNCT
ijpds-2904	242	7	wagner	wagner	PROPN
ijpds-2904	242	8	ch	ch	PROPN
ijpds-2904	242	9	,	,	PUNCT
ijpds-2904	242	10	buß	buß	PROPN
ijpds-2904	242	11	i	i	PROPN
ijpds-2904	242	12	,	,	PUNCT
ijpds-2904	242	13	et	et	PROPN
ijpds-2904	242	14	al	al	PROPN
ijpds-2904	242	15	altered	alter	VERB
ijpds-2904	242	16	localisation	localisation	NOUN
ijpds-2904	242	17	of	of	ADP
ijpds-2904	242	18	the	the	DET
ijpds-2904	242	19	copper	copper	NOUN
ijpds-2904	242	20	efflux	efflux	NOUN
ijpds-2904	242	21	transporters	transporter	NOUN
ijpds-2904	242	22	atp7a	atp7a	NUM
ijpds-2904	242	23	and	and	CCONJ
ijpds-2904	242	24	atp7b	atp7b	PROPN
ijpds-2904	242	25	associated	associate	VERB
ijpds-2904	242	26	with	with	ADP
ijpds-2904	242	27	cisplatin	cisplatin	NOUN
ijpds-2904	242	28	resistance	resistance	NOUN
ijpds-2904	242	29	in	in	ADP
ijpds-2904	242	30	human	human	ADJ
ijpds-2904	242	31	ovarian	ovarian	ADJ
ijpds-2904	242	32	carcinoma	carcinoma	NOUN
ijpds-2904	242	33	cells	cell	NOUN
ijpds-2904	242	34	.	.	PUNCT
ijpds-2904	243	1	bmc	bmc	ADJ
ijpds-2904	243	2	cancer	cancer	NOUN
ijpds-2904	243	3	.	.	PUNCT
ijpds-2904	244	1	2008	2008	NUM
ijpds-2904	244	2	,	,	PUNCT
ijpds-2904	244	3	8:175	8:175	NOUN
ijpds-2904	244	4	-	-	SYM
ijpds-2904	244	5	180	180	NUM
ijpds-2904	244	6	.	.	NOUN
ijpds-2904	244	7	35	35	NUM
ijpds-2904	244	8	.	.	PUNCT
ijpds-2904	245	1	samimi	samimi	PROPN
ijpds-2904	245	2	g	g	NOUN
ijpds-2904	245	3	,	,	PUNCT
ijpds-2904	245	4	safaei	safaei	NOUN
ijpds-2904	245	5	r	r	NOUN
ijpds-2904	245	6	,	,	PUNCT
ijpds-2904	245	7	katano	katano	PROPN
ijpds-2904	245	8	k	k	PROPN
ijpds-2904	245	9	,	,	PUNCT
ijpds-2904	245	10	et	et	PROPN
ijpds-2904	245	11	al	al	PROPN
ijpds-2904	245	12	.	.	PROPN
ijpds-2904	245	13	increased	increase	VERB
ijpds-2904	245	14	expression	expression	NOUN
ijpds-2904	245	15	of	of	ADP
ijpds-2904	245	16	the	the	DET
ijpds-2904	245	17	copper	copper	NOUN
ijpds-2904	245	18	efflux	efflux	NOUN
ijpds-2904	245	19	transporter	transporter	NOUN
ijpds-2904	245	20	atp7a	atp7a	NUM
ijpds-2904	245	21	mediates	mediate	NOUN
ijpds-2904	245	22	resistance	resistance	NOUN
ijpds-2904	245	23	to	to	ADP
ijpds-2904	245	24	cisplatin	cisplatin	NOUN
ijpds-2904	245	25	,	,	PUNCT
ijpds-2904	245	26	carboplatin	carboplatin	NOUN
ijpds-2904	245	27	,	,	PUNCT
ijpds-2904	245	28	and	and	CCONJ
ijpds-2904	245	29	oxaliplatin	oxaliplatin	NOUN
ijpds-2904	245	30	in	in	ADP
ijpds-2904	245	31	ovarian	ovarian	ADJ
ijpds-2904	245	32	cancer	cancer	NOUN
ijpds-2904	245	33	cells	cell	NOUN
ijpds-2904	245	34	.	.	PUNCT
ijpds-2904	246	1	clin	clin	PROPN
ijpds-2904	246	2	cancer	cancer	NOUN
ijpds-2904	246	3	res	re	NOUN
ijpds-2904	246	4	.	.	PUNCT
ijpds-2904	247	1	2004	2004	NUM
ijpds-2904	247	2	,	,	PUNCT
ijpds-2904	247	3	10:4661–9	10:4661–9	NUM
ijpds-2904	247	4	.	.	NOUN
ijpds-2904	247	5	36	36	NUM
ijpds-2904	247	6	.	.	X
ijpds-2904	248	1	wensing	wense	VERB
ijpds-2904	248	2	ku	ku	PROPN
ijpds-2904	248	3	,	,	PUNCT
ijpds-2904	248	4	ciarimboli	ciarimboli	VERB
ijpds-2904	248	5	g	g	NOUN
ijpds-2904	248	6	:	:	PUNCT
ijpds-2904	248	7	saving	save	VERB
ijpds-2904	248	8	ears	ear	NOUN
ijpds-2904	248	9	and	and	CCONJ
ijpds-2904	248	10	kidneys	kidney	NOUN
ijpds-2904	248	11	from	from	ADP
ijpds-2904	248	12	cisplatin	cisplatin	NOUN
ijpds-2904	248	13	.	.	PUNCT
ijpds-2904	249	1	anticancer	anticancer	NOUN
ijpds-2904	249	2	res	re	NOUN
ijpds-2904	249	3	.	.	PUNCT
ijpds-2904	249	4	2013	2013	NUM
ijpds-2904	249	5	,	,	PUNCT
ijpds-2904	249	6	33:4183–8	33:4183–8	NUM
ijpds-2904	249	7	.	.	PUNCT
ijpds-2904	250	1	37	37	NUM
ijpds-2904	250	2	.	.	PUNCT
ijpds-2904	251	1	hagenbuch	hagenbuch	PROPN
ijpds-2904	251	2	b	b	PROPN
ijpds-2904	251	3	:	:	PUNCT
ijpds-2904	251	4	drug	drug	NOUN
ijpds-2904	251	5	uptake	uptake	ADJ
ijpds-2904	251	6	systems	system	NOUN
ijpds-2904	251	7	in	in	ADP
ijpds-2904	251	8	liver	liver	NOUN
ijpds-2904	251	9	and	and	CCONJ
ijpds-2904	251	10	kidney	kidney	NOUN
ijpds-2904	251	11	:	:	PUNCT
ijpds-2904	251	12	a	a	DET
ijpds-2904	251	13	historic	historic	ADJ
ijpds-2904	251	14	perspective	perspective	NOUN
ijpds-2904	251	15	.	.	PUNCT
ijpds-2904	252	1	clin	clin	PROPN
ijpds-2904	252	2	pharmacol	pharmacol	PROPN
ijpds-2904	252	3	ther	ther	ADV
ijpds-2904	252	4	.	.	PUNCT
ijpds-2904	253	1	2010	2010	NUM
ijpds-2904	253	2	,	,	PUNCT
ijpds-2904	253	3	87:39–47	87:39–47	NUM
ijpds-2904	253	4	.	.	PUNCT
ijpds-2904	254	1	38	38	NUM
ijpds-2904	254	2	.	.	PUNCT
ijpds-2904	255	1	ciarimboli	ciarimboli	VERB
ijpds-2904	255	2	g	g	NOUN
ijpds-2904	255	3	:	:	PUNCT
ijpds-2904	255	4	organic	organic	ADJ
ijpds-2904	255	5	cation	cation	NOUN
ijpds-2904	255	6	transporters	transporter	NOUN
ijpds-2904	255	7	.	.	PUNCT
ijpds-2904	256	1	xenobiotica	xenobiotica	PROPN
ijpds-2904	256	2	.	.	PUNCT
ijpds-2904	257	1	2008	2008	NUM
ijpds-2904	257	2	,	,	PUNCT
ijpds-2904	258	1	38:936–71	38:936–71	NOUN
ijpds-2904	258	2	.	.	PUNCT
ijpds-2904	259	1	39	39	NUM
ijpds-2904	259	2	.	.	PUNCT
ijpds-2904	260	1	li	li	PROPN
ijpds-2904	261	1	q	q	PROPN
ijpds-2904	261	2	,	,	PUNCT
ijpds-2904	261	3	guo	guo	PROPN
ijpds-2904	261	4	d	d	PROPN
ijpds-2904	261	5	,	,	PUNCT
ijpds-2904	261	6	dong	dong	PROPN
ijpds-2904	261	7	z	z	PROPN
ijpds-2904	261	8	,	,	PUNCT
ijpds-2904	261	9	et	et	PROPN
ijpds-2904	261	10	al	al	PROPN
ijpds-2904	261	11	.	.	PUNCT
ijpds-2904	261	12	:	:	PUNCT
ijpds-2904	262	1	ondansetron	ondansetron	PROPN
ijpds-2904	262	2	can	can	AUX
ijpds-2904	262	3	enhance	enhance	VERB
ijpds-2904	262	4	cisplatininduced	cisplatininduce	VERB
ijpds-2904	262	5	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	262	6	via	via	ADP
ijpds-2904	262	7	inhibition	inhibition	NOUN
ijpds-2904	262	8	of	of	ADP
ijpds-2904	262	9	multiple	multiple	ADJ
ijpds-2904	262	10	toxin	toxin	NOUN
ijpds-2904	262	11	and	and	CCONJ
ijpds-2904	262	12	extrusion	extrusion	NOUN
ijpds-2904	262	13	proteins	protein	NOUN
ijpds-2904	262	14	(	(	PUNCT
ijpds-2904	262	15	mates	mate	NOUN
ijpds-2904	262	16	)	)	PUNCT
ijpds-2904	262	17	.	.	PUNCT
ijpds-2904	263	1	toxicol	toxicol	PROPN
ijpds-2904	263	2	appl	appl	PROPN
ijpds-2904	263	3	pharmacol	pharmacol	PROPN
ijpds-2904	263	4	.	.	PUNCT
ijpds-2904	264	1	2013	2013	NUM
ijpds-2904	264	2	,	,	PUNCT
ijpds-2904	264	3	273:100–9	273:100–9	NUM
ijpds-2904	264	4	.	.	PUNCT
ijpds-2904	265	1	40	40	NUM
ijpds-2904	265	2	.	.	PUNCT
ijpds-2904	266	1	pabla	pabla	PROPN
ijpds-2904	266	2	n	n	CCONJ
ijpds-2904	266	3	,	,	PUNCT
ijpds-2904	266	4	murphy	murphy	PROPN
ijpds-2904	266	5	rf	rf	PROPN
ijpds-2904	266	6	,	,	PUNCT
ijpds-2904	266	7	liu	liu	PROPN
ijpds-2904	266	8	k	k	PROPN
ijpds-2904	266	9	,	,	PUNCT
ijpds-2904	266	10	dong	dong	PROPN
ijpds-2904	266	11	z	z	PROPN
ijpds-2904	266	12	:	:	PUNCT
ijpds-2904	266	13	the	the	DET
ijpds-2904	266	14	copper	copper	NOUN
ijpds-2904	266	15	transporter	transporter	NOUN
ijpds-2904	266	16	ctr1	ctr1	NOUN
ijpds-2904	266	17	contributes	contribute	VERB
ijpds-2904	266	18	to	to	ADP
ijpds-2904	266	19	cisplatin	cisplatin	NOUN
ijpds-2904	266	20	uptake	uptake	NOUN
ijpds-2904	266	21	by	by	ADP
ijpds-2904	266	22	renal	renal	ADJ
ijpds-2904	266	23	tubular	tubular	ADJ
ijpds-2904	266	24	cells	cell	NOUN
ijpds-2904	266	25	during	during	ADP
ijpds-2904	266	26	cisplatin	cisplatin	NOUN
ijpds-2904	266	27	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	266	28	.	.	PUNCT
ijpds-2904	267	1	am	be	AUX
ijpds-2904	267	2	j	j	PROPN
ijpds-2904	267	3	physiol	physiol	PROPN
ijpds-2904	267	4	physiol	physiol	PROPN
ijpds-2904	267	5	.	.	PUNCT
ijpds-2904	268	1	2009	2009	NUM
ijpds-2904	268	2	,	,	PUNCT
ijpds-2904	268	3	296	296	NUM
ijpds-2904	268	4	:	:	PUNCT
ijpds-2904	268	5	f505	f505	NUM
ijpds-2904	268	6	–	–	PUNCT
ijpds-2904	268	7	11	11	NUM
ijpds-2904	268	8	.	.	X
ijpds-2904	268	9	41	41	NUM
ijpds-2904	268	10	.	.	PUNCT
ijpds-2904	269	1	guo	guo	PROPN
ijpds-2904	269	2	d	d	PROPN
ijpds-2904	269	3	,	,	PUNCT
ijpds-2904	269	4	yang	yang	PROPN
ijpds-2904	269	5	h	h	PROPN
ijpds-2904	269	6	,	,	PUNCT
ijpds-2904	269	7	li	li	PROPN
ijpds-2904	269	8	q	q	PROPN
ijpds-2904	269	9	,	,	PUNCT
ijpds-2904	269	10	et	et	PROPN
ijpds-2904	269	11	al	al	PROPN
ijpds-2904	269	12	.	.	PUNCT
ijpds-2904	269	13	:	:	PUNCT
ijpds-2904	269	14	selective	selective	ADJ
ijpds-2904	269	15	inhibition	inhibition	NOUN
ijpds-2904	269	16	on	on	ADP
ijpds-2904	269	17	organic	organic	ADJ
ijpds-2904	269	18	cation	cation	NOUN
ijpds-2904	269	19	transporters	transporter	NOUN
ijpds-2904	269	20	by	by	ADP
ijpds-2904	269	21	carvedilol	carvedilol	NOUN
ijpds-2904	269	22	protects	protect	VERB
ijpds-2904	269	23	mice	mouse	NOUN
ijpds-2904	269	24	from	from	ADP
ijpds-2904	269	25	cispla	cispla	ADJ
ijpds-2904	269	26	tin	tin	ADV
ijpds-2904	269	27	-	-	PUNCT
ijpds-2904	269	28	induced	induce	VERB
ijpds-2904	269	29	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	269	30	.	.	PUNCT
ijpds-2904	270	1	pharm	pharm	NOUN
ijpds-2904	270	2	res	re	NOUN
ijpds-2904	270	3	.	.	PROPN
ijpds-2904	270	4	2018	2018	NUM
ijpds-2904	270	5	,	,	PUNCT
ijpds-2904	270	6	35	35	NUM
ijpds-2904	270	7	:	:	SYM
ijpds-2904	270	8	204	204	NUM
ijpds-2904	270	9	-10	-10	NUM
ijpds-2904	270	10	.	.	PUNCT
ijpds-2904	271	1	42	42	NUM
ijpds-2904	271	2	.	.	PUNCT
ijpds-2904	272	1	spreckelmeyer	spreckelmeyer	PROPN
ijpds-2904	272	2	s	s	PROPN
ijpds-2904	272	3	,	,	PUNCT
ijpds-2904	272	4	orvig	orvig	NOUN
ijpds-2904	272	5	c	c	NOUN
ijpds-2904	272	6	,	,	PUNCT
ijpds-2904	272	7	casini	casini	VERB
ijpds-2904	272	8	a	a	DET
ijpds-2904	272	9	:	:	PUNCT
ijpds-2904	272	10	cellular	cellular	ADJ
ijpds-2904	272	11	transport	transport	NOUN
ijpds-2904	272	12	mechanisms	mechanism	NOUN
ijpds-2904	272	13	of	of	ADP
ijpds-2904	272	14	cytotoxic	cytotoxic	ADJ
ijpds-2904	272	15	metallodrugs	metallodrug	NOUN
ijpds-2904	272	16	:	:	PUNCT
ijpds-2904	272	17	an	an	DET
ijpds-2904	272	18	overview	overview	NOUN
ijpds-2904	272	19	beyond	beyond	ADP
ijpds-2904	272	20	cisplatin	cisplatin	NOUN
ijpds-2904	272	21	.	.	PUNCT
ijpds-2904	273	1	molecules	molecule	NOUN
ijpds-2904	273	2	.	.	PUNCT
ijpds-2904	274	1	2014	2014	NUM
ijpds-2904	274	2	,	,	PUNCT
ijpds-2904	274	3	19:15584–610	19:15584–610	NUM
ijpds-2904	274	4	.	.	PUNCT
ijpds-2904	275	1	43	43	NUM
ijpds-2904	275	2	.	.	PUNCT
ijpds-2904	276	1	leslie	leslie	PROPN
ijpds-2904	276	2	em	em	PRON
ijpds-2904	276	3	,	,	PUNCT
ijpds-2904	276	4	deeley	deeley	PROPN
ijpds-2904	276	5	rg	rg	PROPN
ijpds-2904	276	6	,	,	PUNCT
ijpds-2904	276	7	cole	cole	PROPN
ijpds-2904	276	8	spc	spc	PROPN
ijpds-2904	276	9	:	:	PUNCT
ijpds-2904	276	10	multidrug	multidrug	VERB
ijpds-2904	276	11	resistance	resistance	NOUN
ijpds-2904	276	12	proteins	protein	NOUN
ijpds-2904	276	13	:	:	PUNCT
ijpds-2904	276	14	role	role	NOUN
ijpds-2904	276	15	of	of	ADP
ijpds-2904	276	16	p	p	NOUN
ijpds-2904	276	17	-	-	PUNCT
ijpds-2904	276	18	glycoprotein	glycoprotein	NOUN
ijpds-2904	276	19	,	,	PUNCT
ijpds-2904	276	20	mrp1	mrp1	NOUN
ijpds-2904	276	21	,	,	PUNCT
ijpds-2904	276	22	mrp2	mrp2	PROPN
ijpds-2904	276	23	,	,	PUNCT
ijpds-2904	276	24	and	and	CCONJ
ijpds-2904	276	25	bcrp	bcrp	PROPN
ijpds-2904	276	26	(	(	PUNCT
ijpds-2904	276	27	abcg2	abcg2	NOUN
ijpds-2904	276	28	)	)	PUNCT
ijpds-2904	276	29	in	in	ADP
ijpds-2904	276	30	tissue	tissue	NOUN
ijpds-2904	276	31	defense	defense	NOUN
ijpds-2904	276	32	.	.	PUNCT
ijpds-2904	277	1	toxicol	toxicol	PROPN
ijpds-2904	277	2	appl	appl	PROPN
ijpds-2904	277	3	pharmacol	pharmacol	PROPN
ijpds-2904	277	4	.	.	PUNCT
ijpds-2904	278	1	2005	2005	NUM
ijpds-2904	278	2	,	,	PUNCT
ijpds-2904	278	3	204:216–37	204:216–37	NUM
ijpds-2904	278	4	.	.	PUNCT
ijpds-2904	279	1	how	how	SCONJ
ijpds-2904	279	2	to	to	PART
ijpds-2904	279	3	cite	cite	VERB
ijpds-2904	279	4	this	this	DET
ijpds-2904	279	5	article	article	NOUN
ijpds-2904	279	6	:	:	PUNCT
ijpds-2904	279	7	sakshi	sakshi	PROPN
ijpds-2904	279	8	,	,	PUNCT
ijpds-2904	279	9	gaaminepreet	gaaminepreet	PROPN
ijpds-2904	279	10	singh	singh	PROPN
ijpds-2904	279	11	.	.	PUNCT
ijpds-2904	280	1	role	role	NOUN
ijpds-2904	280	2	of	of	ADP
ijpds-2904	280	3	membrane	membrane	ADJ
ijpds-2904	280	4	proteins	protein	NOUN
ijpds-2904	280	5	in	in	ADP
ijpds-2904	280	6	cisplatin	cisplatin	NOUN
ijpds-2904	280	7	induced	induce	VERB
ijpds-2904	280	8	nephrotoxicity	nephrotoxicity	NOUN
ijpds-2904	280	9	.	.	PUNCT
ijpds-2904	281	1	indian	indian	PROPN
ijpds-2904	281	2	j	j	PROPN
ijpds-2904	281	3	pharm	pharm	PROPN
ijpds-2904	281	4	drug	drug	PROPN
ijpds-2904	281	5	studies	study	NOUN
ijpds-2904	281	6	.	.	PUNCT
ijpds-2904	282	1	2022	2022	NUM
ijpds-2904	282	2	:	:	PUNCT
ijpds-2904	282	3	1(1	1(1	NUM
ijpds-2904	282	4	)	)	PUNCT
ijpds-2904	282	5	;	;	PUNCT
ijpds-2904	283	1	5	5	NUM
ijpds-2904	283	2	-	-	SYM
ijpds-2904	283	3	9	9	NUM
ijpds-2904	283	4	.	.	X
ijpds-2904	283	5	funding	funding	NOUN
ijpds-2904	283	6	:	:	PUNCT
ijpds-2904	283	7	none	none	NOUN
ijpds-2904	283	8	conflict	conflict	NOUN
ijpds-2904	283	9	of	of	ADP
ijpds-2904	283	10	interest	interest	NOUN
ijpds-2904	283	11	:	:	PUNCT
ijpds-2904	283	12	none	none	NOUN
ijpds-2904	283	13	stated	state	VERB