id	sid	tid	token	lemma	pos
ijpds-2950	1	1	sujeetha	sujeetha	PROPN
ijpds-2950	1	2	&	&	CCONJ
ijpds-2950	1	3	anand	anand	PROPN
ijpds-2950	1	4	cholesterol	cholesterol	PROPN
ijpds-2950	1	5	and	and	CCONJ
ijpds-2950	1	6	alzheimer	alzheimer	PROPN
ijpds-2950	1	7	’s	’s	PART
ijpds-2950	1	8	vol	vol	NOUN
ijpds-2950	1	9	1	1	NUM
ijpds-2950	1	10	|	|	ADV
ijpds-2950	1	11	issue	issue	VERB
ijpds-2950	1	12	1	1	NUM
ijpds-2950	1	13	|	|	ADV
ijpds-2950	1	14	apr	apr	ADV
ijpds-2950	1	15	–	–	PUNCT
ijpds-2950	1	16	jun	jun	PROPN
ijpds-2950	1	17	2022	2022	NUM
ijpds-2950	1	18	indian	indian	PROPN
ijpds-2950	1	19	j	j	PROPN
ijpds-2950	1	20	pharm	pharm	PROPN
ijpds-2950	1	21	drug	drug	PROPN
ijpds-2950	1	22	studies	study	NOUN
ijpds-2950	1	23	|	|	ADV
ijpds-2950	1	24	10	10	NUM
ijpds-2950	1	25	review	review	NOUN
ijpds-2950	1	26	article	article	NOUN
ijpds-2950	1	27	the	the	DET
ijpds-2950	1	28	link	link	NOUN
ijpds-2950	1	29	between	between	ADP
ijpds-2950	1	30	cholesterol	cholesterol	NOUN
ijpds-2950	1	31	and	and	CCONJ
ijpds-2950	1	32	a	a	DET
ijpds-2950	1	33	brain	brain	NOUN
ijpds-2950	1	34	disease	disease	NOUN
ijpds-2950	1	35	sujeetha	sujeetha	NOUN
ijpds-2950	1	36	purushothaman1	purushothaman1	PROPN
ijpds-2950	1	37	,	,	PUNCT
ijpds-2950	1	38	arumugan	arumugan	PROPN
ijpds-2950	1	39	vijaya	vijaya	PROPN
ijpds-2950	1	40	anand1	anand1	PROPN
ijpds-2950	1	41	from	from	ADP
ijpds-2950	1	42	,	,	PUNCT
ijpds-2950	1	43	1medical	1medical	NUM
ijpds-2950	1	44	genetics	genetic	NOUN
ijpds-2950	1	45	and	and	CCONJ
ijpds-2950	1	46	epigenetics	epigenetic	NOUN
ijpds-2950	1	47	laboratory	laboratory	NOUN
ijpds-2950	1	48	,	,	PUNCT
ijpds-2950	1	49	department	department	NOUN
ijpds-2950	1	50	of	of	ADP
ijpds-2950	1	51	human	human	ADJ
ijpds-2950	1	52	genetics	genetic	NOUN
ijpds-2950	1	53	and	and	CCONJ
ijpds-2950	1	54	molecular	molecular	ADJ
ijpds-2950	1	55	biology	biology	NOUN
ijpds-2950	1	56	,	,	PUNCT
ijpds-2950	1	57	bharathiar	bharathiar	PROPN
ijpds-2950	1	58	university	university	PROPN
ijpds-2950	1	59	,	,	PUNCT
ijpds-2950	1	60	coimbatore	coimbatore	PROPN
ijpds-2950	1	61	,	,	PUNCT
ijpds-2950	1	62	tamil	tamil	PROPN
ijpds-2950	1	63	nadu	nadu	PROPN
ijpds-2950	1	64	,	,	PUNCT
ijpds-2950	1	65	india	india	PROPN
ijpds-2950	1	66	.	.	PUNCT
ijpds-2950	2	1	correspondence	correspondence	NOUN
ijpds-2950	2	2	to	to	ADP
ijpds-2950	2	3	:	:	PUNCT
ijpds-2950	2	4	sujeetha	sujeetha	VERB
ijpds-2950	2	5	purushothaman	purushothaman	NOUN
ijpds-2950	2	6	,	,	PUNCT
ijpds-2950	2	7	medical	medical	ADJ
ijpds-2950	2	8	genetics	genetic	NOUN
ijpds-2950	2	9	and	and	CCONJ
ijpds-2950	2	10	epigenetics	epigenetic	NOUN
ijpds-2950	2	11	laboratory	laboratory	NOUN
ijpds-2950	2	12	,	,	PUNCT
ijpds-2950	2	13	department	department	NOUN
ijpds-2950	2	14	of	of	ADP
ijpds-2950	2	15	human	human	ADJ
ijpds-2950	2	16	genetics	genetic	NOUN
ijpds-2950	2	17	and	and	CCONJ
ijpds-2950	2	18	molecular	molecular	ADJ
ijpds-2950	2	19	biology	biology	NOUN
ijpds-2950	2	20	,	,	PUNCT
ijpds-2950	2	21	bharathiar	bharathiar	PROPN
ijpds-2950	2	22	university	university	PROPN
ijpds-2950	2	23	,	,	PUNCT
ijpds-2950	2	24	coimbatore	coimbatore	PROPN
ijpds-2950	2	25	641046	641046	NUM
ijpds-2950	2	26	.	.	PUNCT
ijpds-2950	3	1	tamil	tamil	PROPN
ijpds-2950	3	2	nadu	nadu	PROPN
ijpds-2950	3	3	,	,	PUNCT
ijpds-2950	3	4	india	india	PROPN
ijpds-2950	3	5	.	.	PUNCT
ijpds-2950	3	6	email	email	NOUN
ijpds-2950	3	7	:	:	PUNCT
ijpds-2950	3	8	suji648@yahoo.co.in	suji648@yahoo.co.in	VERB
ijpds-2950	3	9	abstract	abstract	ADJ
ijpds-2950	3	10	lipids	lipid	NOUN
ijpds-2950	3	11	comprise	comprise	VERB
ijpds-2950	3	12	the	the	DET
ijpds-2950	3	13	immensity	immensity	ADJ
ijpds-2950	3	14	dry	dry	ADJ
ijpds-2950	3	15	mass	mass	NOUN
ijpds-2950	3	16	of	of	ADP
ijpds-2950	3	17	the	the	DET
ijpds-2950	3	18	brain	brain	NOUN
ijpds-2950	3	19	and	and	CCONJ
ijpds-2950	3	20	these	these	PRON
ijpds-2950	3	21	have	have	AUX
ijpds-2950	3	22	been	be	AUX
ijpds-2950	3	23	allied	ally	VERB
ijpds-2950	3	24	with	with	ADP
ijpds-2950	3	25	healthy	healthy	ADJ
ijpds-2950	3	26	function	function	NOUN
ijpds-2950	3	27	as	as	ADV
ijpds-2950	3	28	well	well	ADV
ijpds-2950	3	29	as	as	ADP
ijpds-2950	3	30	the	the	DET
ijpds-2950	3	31	most	most	ADV
ijpds-2950	3	32	common	common	ADJ
ijpds-2950	3	33	pathological	pathological	ADJ
ijpds-2950	3	34	circumstances	circumstance	NOUN
ijpds-2950	3	35	of	of	ADP
ijpds-2950	3	36	the	the	DET
ijpds-2950	3	37	brain	brain	NOUN
ijpds-2950	3	38	.	.	PUNCT
ijpds-2950	4	1	genetics	genetic	NOUN
ijpds-2950	4	2	and	and	CCONJ
ijpds-2950	4	3	lifestyles	lifestyle	NOUN
ijpds-2950	4	4	are	be	AUX
ijpds-2950	4	5	the	the	DET
ijpds-2950	4	6	most	most	ADV
ijpds-2950	4	7	important	important	ADJ
ijpds-2950	4	8	factor	factor	NOUN
ijpds-2950	4	9	that	that	PRON
ijpds-2950	4	10	influences	influence	VERB
ijpds-2950	4	11	the	the	DET
ijpds-2950	4	12	lipid	lipid	NOUN
ijpds-2950	4	13	metabolism	metabolism	NOUN
ijpds-2950	4	14	and	and	CCONJ
ijpds-2950	4	15	the	the	DET
ijpds-2950	4	16	key	key	ADJ
ijpds-2950	4	17	components	component	NOUN
ijpds-2950	4	18	of	of	ADP
ijpds-2950	4	19	lipid	lipid	ADJ
ijpds-2950	4	20	disruption	disruption	NOUN
ijpds-2950	4	21	in	in	ADP
ijpds-2950	4	22	alzheimer	alzheimer	PROPN
ijpds-2950	4	23	’s	’s	PART
ijpds-2950	4	24	disease	disease	NOUN
ijpds-2950	4	25	(	(	PUNCT
ijpds-2950	4	26	ad	ad	NOUN
ijpds-2950	4	27	)	)	PUNCT
ijpds-2950	4	28	.	.	PUNCT
ijpds-2950	5	1	additionally	additionally	ADV
ijpds-2950	5	2	,	,	PUNCT
ijpds-2950	5	3	the	the	DET
ijpds-2950	5	4	most	most	ADV
ijpds-2950	5	5	common	common	ADJ
ijpds-2950	5	6	genetic	genetic	ADJ
ijpds-2950	5	7	risk	risk	NOUN
ijpds-2950	5	8	factor	factor	NOUN
ijpds-2950	5	9	of	of	ADP
ijpds-2950	5	10	ad	ad	NOUN
ijpds-2950	5	11	,	,	PUNCT
ijpds-2950	5	12	apoe	apoe	ADJ
ijpds-2950	5	13	e4	e4	PROPN
ijpds-2950	5	14	genotype	genotype	NOUN
ijpds-2950	5	15	,	,	PUNCT
ijpds-2950	5	16	is	be	AUX
ijpds-2950	5	17	involved	involve	VERB
ijpds-2950	5	18	in	in	ADP
ijpds-2950	5	19	lipid	lipid	NOUN
ijpds-2950	5	20	transport	transport	NOUN
ijpds-2950	5	21	and	and	CCONJ
ijpds-2950	5	22	metabolism	metabolism	NOUN
ijpds-2950	5	23	.	.	PUNCT
ijpds-2950	6	1	under	under	ADP
ijpds-2950	6	2	healthy	healthy	ADJ
ijpds-2950	6	3	conditions	condition	NOUN
ijpds-2950	6	4	,	,	PUNCT
ijpds-2950	6	5	lipid	lipid	NOUN
ijpds-2950	6	6	homeostasis	homeostasis	NOUN
ijpds-2950	6	7	bestows	bestow	VERB
ijpds-2950	6	8	a	a	DET
ijpds-2950	6	9	balanced	balanced	ADJ
ijpds-2950	6	10	cellular	cellular	ADJ
ijpds-2950	6	11	environment	environment	NOUN
ijpds-2950	6	12	that	that	PRON
ijpds-2950	6	13	enables	enable	VERB
ijpds-2950	6	14	the	the	DET
ijpds-2950	6	15	proper	proper	ADJ
ijpds-2950	6	16	functioning	functioning	NOUN
ijpds-2950	6	17	of	of	ADP
ijpds-2950	6	18	brain	brain	NOUN
ijpds-2950	6	19	cells	cell	NOUN
ijpds-2950	6	20	.	.	PUNCT
ijpds-2950	7	1	however	however	ADV
ijpds-2950	7	2	,	,	PUNCT
ijpds-2950	7	3	under	under	ADP
ijpds-2950	7	4	pathological	pathological	ADJ
ijpds-2950	7	5	conditions	condition	NOUN
ijpds-2950	7	6	,	,	PUNCT
ijpds-2950	7	7	dyshomeostasis	dyshomeostasis	NOUN
ijpds-2950	7	8	of	of	ADP
ijpds-2950	7	9	brain	brain	NOUN
ijpds-2950	7	10	lipid	lipid	NOUN
ijpds-2950	7	11	can	can	AUX
ijpds-2950	7	12	result	result	VERB
ijpds-2950	7	13	in	in	ADP
ijpds-2950	7	14	disturbed	disturbed	ADJ
ijpds-2950	7	15	bbb	bbb	NOUN
ijpds-2950	7	16	,	,	PUNCT
ijpds-2950	7	17	abnormal	abnormal	ADJ
ijpds-2950	7	18	processing	processing	NOUN
ijpds-2950	7	19	of	of	ADP
ijpds-2950	7	20	app	app	NOUN
ijpds-2950	7	21	,	,	PUNCT
ijpds-2950	7	22	dysfunction	dysfunction	NOUN
ijpds-2950	7	23	in	in	ADP
ijpds-2950	7	24	endocytosis	endocytosis	NOUN
ijpds-2950	7	25	/	/	SYM
ijpds-2950	7	26	exocytose	exocytose	NOUN
ijpds-2950	7	27	/	/	SYM
ijpds-2950	7	28	autophagocytos	autophagocyto	NOUN
ijpds-2950	7	29	is	be	AUX
ijpds-2950	7	30	,	,	PUNCT
ijpds-2950	7	31	altered	altered	ADJ
ijpds-2950	7	32	myelination	myelination	NOUN
ijpds-2950	7	33	,	,	PUNCT
ijpds-2950	7	34	disturbed	disturbed	ADJ
ijpds-2950	7	35	signaling	signal	VERB
ijpds-2950	7	36	,	,	PUNCT
ijpds-2950	7	37	unbalanced	unbalanced	ADJ
ijpds-2950	7	38	energy	energy	NOUN
ijpds-2950	7	39	metabolism	metabolism	NOUN
ijpds-2950	7	40	,	,	PUNCT
ijpds-2950	7	41	and	and	CCONJ
ijpds-2950	7	42	enhanced	enhance	VERB
ijpds-2950	7	43	inflammation	inflammation	NOUN
ijpds-2950	7	44	.	.	PUNCT
ijpds-2950	8	1	this	this	DET
ijpds-2950	8	2	lipid	lipid	NOUN
ijpds-2950	8	3	instability	instability	NOUN
ijpds-2950	8	4	may	may	AUX
ijpds-2950	8	5	contribute	contribute	VERB
ijpds-2950	8	6	to	to	ADP
ijpds-2950	8	7	abnormalities	abnormality	NOUN
ijpds-2950	8	8	in	in	ADP
ijpds-2950	8	9	brain	brain	NOUN
ijpds-2950	8	10	function	function	NOUN
ijpds-2950	8	11	that	that	PRON
ijpds-2950	8	12	are	be	AUX
ijpds-2950	8	13	the	the	DET
ijpds-2950	8	14	hallmark	hallmark	NOUN
ijpds-2950	8	15	of	of	ADP
ijpds-2950	8	16	ad	ad	NOUN
ijpds-2950	8	17	.	.	PUNCT
ijpds-2950	9	1	in	in	ADP
ijpds-2950	9	2	this	this	DET
ijpds-2950	9	3	review	review	NOUN
ijpds-2950	9	4	,	,	PUNCT
ijpds-2950	9	5	we	we	PRON
ijpds-2950	9	6	focus	focus	VERB
ijpds-2950	9	7	on	on	ADP
ijpds-2950	9	8	the	the	DET
ijpds-2950	9	9	lipid	lipid	NOUN
ijpds-2950	9	10	and	and	CCONJ
ijpds-2950	9	11	cholesterol	cholesterol	NOUN
ijpds-2950	9	12	metabolism	metabolism	NOUN
ijpds-2950	9	13	,	,	PUNCT
ijpds-2950	9	14	with	with	ADP
ijpds-2950	9	15	an	an	DET
ijpds-2950	9	16	overview	overview	NOUN
ijpds-2950	9	17	of	of	ADP
ijpds-2950	9	18	the	the	DET
ijpds-2950	9	19	various	various	ADJ
ijpds-2950	9	20	lipid	lipid	NOUN
ijpds-2950	9	21	and	and	CCONJ
ijpds-2950	9	22	cholesterol	cholesterol	NOUN
ijpds-2950	9	23	metabolic	metabolic	NOUN
ijpds-2950	9	24	pathways	pathway	NOUN
ijpds-2950	9	25	and	and	CCONJ
ijpds-2950	9	26	changes	change	NOUN
ijpds-2950	9	27	that	that	PRON
ijpds-2950	9	28	have	have	AUX
ijpds-2950	9	29	been	be	AUX
ijpds-2950	9	30	linked	link	VERB
ijpds-2950	9	31	to	to	ADP
ijpds-2950	9	32	ad	ad	NOUN
ijpds-2950	9	33	.	.	PUNCT
ijpds-2950	10	1	key	key	ADJ
ijpds-2950	10	2	words	word	NOUN
ijpds-2950	10	3	:	:	PUNCT
ijpds-2950	10	4	alzheimer	alzheimer	PROPN
ijpds-2950	10	5	’s	’s	PART
ijpds-2950	10	6	disease	disease	NOUN
ijpds-2950	10	7	,	,	PUNCT
ijpds-2950	10	8	lipid	lipid	NOUN
ijpds-2950	10	9	homeostasis	homeostasis	NOUN
ijpds-2950	10	10	,	,	PUNCT
ijpds-2950	10	11	inflammation	inflammation	NOUN
ijpds-2950	10	12	,	,	PUNCT
ijpds-2950	10	13	apolipoprotein	apolipoprotein	ADJ
ijpds-2950	10	14	e	e	PROPN
ijpds-2950	10	15	eregulated	eregulate	VERB
ijpds-2950	10	16	lipid	lipid	NOUN
ijpds-2950	10	17	and	and	CCONJ
ijpds-2950	10	18	cholesterol	cholesterol	NOUN
ijpds-2950	10	19	homeostasis	homeostasis	NOUN
ijpds-2950	10	20	in	in	ADP
ijpds-2950	10	21	the	the	DET
ijpds-2950	10	22	body	body	NOUN
ijpds-2950	10	23	and	and	CCONJ
ijpds-2950	10	24	particularly	particularly	ADV
ijpds-2950	10	25	in	in	ADP
ijpds-2950	10	26	the	the	DET
ijpds-2950	10	27	brain	brain	NOUN
ijpds-2950	10	28	has	have	AUX
ijpds-2950	10	29	been	be	AUX
ijpds-2950	10	30	demonstrated	demonstrate	VERB
ijpds-2950	10	31	in	in	ADP
ijpds-2950	10	32	neurodegenerative	neurodegenerative	ADJ
ijpds-2950	10	33	diseases	disease	NOUN
ijpds-2950	10	34	such	such	ADJ
ijpds-2950	10	35	as	as	ADP
ijpds-2950	10	36	alzheimer	alzheimer	PROPN
ijpds-2950	10	37	’s	’s	PART
ijpds-2950	10	38	disease	disease	NOUN
ijpds-2950	10	39	(	(	PUNCT
ijpds-2950	10	40	ad	ad	NOUN
ijpds-2950	10	41	)	)	PUNCT
ijpds-2950	10	42	,	,	PUNCT
ijpds-2950	10	43	as	as	ADV
ijpds-2950	10	44	well	well	ADV
ijpds-2950	10	45	as	as	ADP
ijpds-2950	10	46	parkinson	parkinson	NOUN
ijpds-2950	10	47	’s	’s	PART
ijpds-2950	10	48	disease	disease	NOUN
ijpds-2950	10	49	(	(	PUNCT
ijpds-2950	10	50	pd	pd	NOUN
ijpds-2950	10	51	)	)	PUNCT
ijpds-2950	10	52	and	and	CCONJ
ijpds-2950	10	53	huntington	huntington	PROPN
ijpds-2950	10	54	’s	’s	PART
ijpds-2950	10	55	disease	disease	NOUN
ijpds-2950	10	56	(	(	PUNCT
ijpds-2950	10	57	hd	hd	NOUN
ijpds-2950	10	58	)	)	PUNCT
ijpds-2950	11	1	[	[	X
ijpds-2950	11	2	1	1	NUM
ijpds-2950	11	3	]	]	PUNCT
ijpds-2950	11	4	.	.	PUNCT
ijpds-2950	12	1	the	the	DET
ijpds-2950	12	2	changes	change	NOUN
ijpds-2950	12	3	in	in	ADP
ijpds-2950	12	4	lipid	lipid	ADJ
ijpds-2950	12	5	metabolism	metabolism	NOUN
ijpds-2950	12	6	may	may	AUX
ijpds-2950	12	7	affect	affect	VERB
ijpds-2950	12	8	the	the	DET
ijpds-2950	12	9	disease	disease	NOUN
ijpds-2950	12	10	progression	progression	NOUN
ijpds-2950	12	11	or	or	CCONJ
ijpds-2950	12	12	pathogenic	pathogenic	ADJ
ijpds-2950	12	13	mechanism	mechanism	NOUN
ijpds-2950	12	14	.	.	PUNCT
ijpds-2950	13	1	amyloidogenic	amyloidogenic	ADJ
ijpds-2950	13	2	peptide	peptide	NOUN
ijpds-2950	13	3	is	be	AUX
ijpds-2950	13	4	believed	believe	VERB
ijpds-2950	13	5	to	to	PART
ijpds-2950	13	6	play	play	VERB
ijpds-2950	13	7	a	a	DET
ijpds-2950	13	8	key	key	ADJ
ijpds-2950	13	9	role	role	NOUN
ijpds-2950	13	10	in	in	ADP
ijpds-2950	13	11	the	the	DET
ijpds-2950	13	12	ad	ad	NOUN
ijpds-2950	13	13	pathogenesis	pathogenesis	NOUN
ijpds-2950	13	14	mounting	mount	VERB
ijpds-2950	13	15	the	the	DET
ijpds-2950	13	16	evidence	evidence	NOUN
ijpds-2950	13	17	that	that	PRON
ijpds-2950	13	18	dyslipidemia	dyslipidemia	NOUN
ijpds-2950	13	19	provoke	provoke	VERB
ijpds-2950	13	20	the	the	DET
ijpds-2950	13	21	production	production	NOUN
ijpds-2950	13	22	or	or	CCONJ
ijpds-2950	13	23	reduce	reduce	NOUN
ijpds-2950	13	24	of	of	ADP
ijpds-2950	13	25	amyloid	amyloid	NOUN
ijpds-2950	13	26	beta	beta	NOUN
ijpds-2950	13	27	(	(	PUNCT
ijpds-2950	13	28	aβ	aβ	NOUN
ijpds-2950	13	29	)	)	PUNCT
ijpds-2950	13	30	clearance	clearance	NOUN
ijpds-2950	14	1	[	[	X
ijpds-2950	14	2	2	2	NUM
ijpds-2950	14	3	]	]	PUNCT
ijpds-2950	14	4	.	.	PUNCT
ijpds-2950	15	1	moreover	moreover	ADV
ijpds-2950	15	2	,	,	PUNCT
ijpds-2950	15	3	other	other	ADJ
ijpds-2950	15	4	dyslipidemic	dyslipidemic	ADJ
ijpds-2950	15	5	-	-	PUNCT
ijpds-2950	15	6	related	relate	VERB
ijpds-2950	15	7	conditions	condition	NOUN
ijpds-2950	15	8	have	have	AUX
ijpds-2950	15	9	also	also	ADV
ijpds-2950	15	10	been	be	AUX
ijpds-2950	15	11	linked	link	VERB
ijpds-2950	15	12	in	in	ADP
ijpds-2950	15	13	the	the	DET
ijpds-2950	15	14	ad	ad	NOUN
ijpds-2950	15	15	pathogenesis	pathogenesis	NOUN
ijpds-2950	15	16	,	,	PUNCT
ijpds-2950	15	17	including	include	VERB
ijpds-2950	15	18	obesity	obesity	NOUN
ijpds-2950	15	19	,	,	PUNCT
ijpds-2950	15	20	hypertension	hypertension	NOUN
ijpds-2950	15	21	,	,	PUNCT
ijpds-2950	15	22	inflammation	inflammation	NOUN
ijpds-2950	15	23	,	,	PUNCT
ijpds-2950	15	24	insulin	insulin	NOUN
ijpds-2950	15	25	resistance	resistance	NOUN
ijpds-2950	15	26	,	,	PUNCT
ijpds-2950	15	27	and	and	CCONJ
ijpds-2950	15	28	type	type	NOUN
ijpds-2950	15	29	2	2	NUM
ijpds-2950	15	30	diabetes	diabetes	NOUN
ijpds-2950	15	31	[	[	X
ijpds-2950	15	32	3	3	NUM
ijpds-2950	15	33	]	]	PUNCT
ijpds-2950	15	34	.	.	PUNCT
ijpds-2950	16	1	in	in	ADP
ijpds-2950	16	2	this	this	DET
ijpds-2950	16	3	review	review	NOUN
ijpds-2950	16	4	,	,	PUNCT
ijpds-2950	16	5	we	we	PRON
ijpds-2950	16	6	focus	focus	VERB
ijpds-2950	16	7	on	on	ADP
ijpds-2950	16	8	the	the	DET
ijpds-2950	16	9	lipid	lipid	NOUN
ijpds-2950	16	10	and	and	CCONJ
ijpds-2950	16	11	cholesterol	cholesterol	NOUN
ijpds-2950	16	12	metabolism	metabolism	NOUN
ijpds-2950	16	13	,	,	PUNCT
ijpds-2950	16	14	with	with	ADP
ijpds-2950	16	15	an	an	DET
ijpds-2950	16	16	overview	overview	NOUN
ijpds-2950	16	17	of	of	ADP
ijpds-2950	16	18	the	the	DET
ijpds-2950	16	19	various	various	ADJ
ijpds-2950	16	20	lipid	lipid	NOUN
ijpds-2950	16	21	and	and	CCONJ
ijpds-2950	16	22	cholesterol	cholesterol	NOUN
ijpds-2950	16	23	metabolic	metabolic	NOUN
ijpds-2950	16	24	pathways	pathway	NOUN
ijpds-2950	16	25	and	and	CCONJ
ijpds-2950	16	26	changes	change	NOUN
ijpds-2950	16	27	that	that	PRON
ijpds-2950	16	28	have	have	AUX
ijpds-2950	16	29	been	be	AUX
ijpds-2950	16	30	linked	link	VERB
ijpds-2950	16	31	to	to	ADP
ijpds-2950	16	32	ad	ad	NOUN
ijpds-2950	16	33	.	.	PUNCT
ijpds-2950	17	1	cholesterol	cholesterol	NOUN
ijpds-2950	17	2	and	and	CCONJ
ijpds-2950	17	3	lipid	lipid	NOUN
ijpds-2950	17	4	metabolism	metabolism	NOUN
ijpds-2950	17	5	rising	rise	VERB
ijpds-2950	17	6	evidence	evidence	NOUN
ijpds-2950	17	7	suggest	suggest	VERB
ijpds-2950	17	8	the	the	DET
ijpds-2950	17	9	changes	change	NOUN
ijpds-2950	17	10	in	in	ADP
ijpds-2950	17	11	the	the	DET
ijpds-2950	17	12	metabolism	metabolism	NOUN
ijpds-2950	17	13	of	of	ADP
ijpds-2950	17	14	lipids	lipid	NOUN
ijpds-2950	17	15	,	,	PUNCT
ijpds-2950	17	16	predominantly	predominantly	ADV
ijpds-2950	17	17	cholesterol	cholesterol	NOUN
ijpds-2950	17	18	,	,	PUNCT
ijpds-2950	17	19	is	be	AUX
ijpds-2950	17	20	implicated	implicate	VERB
ijpds-2950	17	21	directly	directly	ADV
ijpds-2950	17	22	in	in	ADP
ijpds-2950	17	23	the	the	DET
ijpds-2950	17	24	pathogenesis	pathogenesis	NOUN
ijpds-2950	17	25	of	of	ADP
ijpds-2950	17	26	many	many	ADJ
ijpds-2950	17	27	neurodegenerative	neurodegenerative	ADJ
ijpds-2950	17	28	disease	disease	NOUN
ijpds-2950	17	29	including	include	VERB
ijpds-2950	17	30	ad	ad	NOUN
ijpds-2950	17	31	[	[	X
ijpds-2950	17	32	2	2	NUM
ijpds-2950	17	33	]	]	PUNCT
ijpds-2950	17	34	.	.	PUNCT
ijpds-2950	18	1	this	this	DET
ijpds-2950	18	2	part	part	NOUN
ijpds-2950	18	3	describes	describe	VERB
ijpds-2950	18	4	the	the	DET
ijpds-2950	18	5	cholesterol	cholesterol	NOUN
ijpds-2950	18	6	synthesis	synthesis	NOUN
ijpds-2950	18	7	and	and	CCONJ
ijpds-2950	18	8	metabolism	metabolism	NOUN
ijpds-2950	18	9	followed	follow	VERB
ijpds-2950	18	10	by	by	ADP
ijpds-2950	18	11	some	some	DET
ijpds-2950	18	12	vital	vital	ADJ
ijpds-2950	18	13	information	information	NOUN
ijpds-2950	18	14	about	about	ADP
ijpds-2950	18	15	the	the	DET
ijpds-2950	18	16	lipid	lipid	NOUN
ijpds-2950	18	17	transport	transport	NOUN
ijpds-2950	18	18	and	and	CCONJ
ijpds-2950	18	19	metabolism	metabolism	NOUN
ijpds-2950	18	20	,	,	PUNCT
ijpds-2950	18	21	in	in	ADP
ijpds-2950	18	22	order	order	NOUN
ijpds-2950	18	23	to	to	PART
ijpds-2950	18	24	explain	explain	VERB
ijpds-2950	18	25	the	the	DET
ijpds-2950	18	26	normal	normal	ADJ
ijpds-2950	18	27	roles	role	NOUN
ijpds-2950	18	28	of	of	ADP
ijpds-2950	18	29	these	these	DET
ijpds-2950	18	30	lipids	lipid	NOUN
ijpds-2950	18	31	in	in	ADP
ijpds-2950	18	32	the	the	DET
ijpds-2950	18	33	body	body	NOUN
ijpds-2950	18	34	and	and	CCONJ
ijpds-2950	18	35	the	the	DET
ijpds-2950	18	36	brain	brain	NOUN
ijpds-2950	18	37	.	.	PUNCT
ijpds-2950	19	1	some	some	DET
ijpds-2950	19	2	changes	change	NOUN
ijpds-2950	19	3	in	in	ADP
ijpds-2950	19	4	lipid	lipid	ADJ
ijpds-2950	19	5	metabolisms	metabolism	NOUN
ijpds-2950	19	6	which	which	PRON
ijpds-2950	19	7	have	have	AUX
ijpds-2950	19	8	been	be	AUX
ijpds-2950	19	9	detected	detect	VERB
ijpds-2950	19	10	in	in	ADP
ijpds-2950	19	11	ad	ad	NOUN
ijpds-2950	19	12	[	[	X
ijpds-2950	19	13	4	4	NUM
ijpds-2950	19	14	]	]	PUNCT
ijpds-2950	19	15	.	.	PUNCT
ijpds-2950	20	1	cholesterol	cholesterol	NOUN
ijpds-2950	20	2	synthesis	synthesis	NOUN
ijpds-2950	20	3	and	and	CCONJ
ijpds-2950	20	4	metabolism	metabolism	NOUN
ijpds-2950	20	5	cholesterol	cholesterol	NOUN
ijpds-2950	20	6	plays	play	VERB
ijpds-2950	20	7	a	a	DET
ijpds-2950	20	8	vital	vital	ADJ
ijpds-2950	20	9	function	function	NOUN
ijpds-2950	20	10	in	in	ADP
ijpds-2950	20	11	the	the	DET
ijpds-2950	20	12	structure	structure	NOUN
ijpds-2950	20	13	and	and	CCONJ
ijpds-2950	20	14	function	function	NOUN
ijpds-2950	20	15	of	of	ADP
ijpds-2950	20	16	cell	cell	NOUN
ijpds-2950	20	17	membranes	membrane	NOUN
ijpds-2950	20	18	.	.	PUNCT
ijpds-2950	21	1	it	it	PRON
ijpds-2950	21	2	influences	influence	VERB
ijpds-2950	21	3	the	the	DET
ijpds-2950	21	4	inflexibility	inflexibility	NOUN
ijpds-2950	21	5	of	of	ADP
ijpds-2950	21	6	lipid	lipid	ADJ
ijpds-2950	21	7	bilayers	bilayer	NOUN
ijpds-2950	21	8	,	,	PUNCT
ijpds-2950	21	9	there	there	PRON
ijpds-2950	21	10	in	in	ADP
ijpds-2950	21	11	affects	affect	VERB
ijpds-2950	21	12	the	the	DET
ijpds-2950	21	13	transfer	transfer	NOUN
ijpds-2950	21	14	and	and	CCONJ
ijpds-2950	21	15	process	process	NOUN
ijpds-2950	21	16	through	through	ADP
ijpds-2950	21	17	the	the	DET
ijpds-2950	21	18	membrane	membrane	NOUN
ijpds-2950	21	19	.	.	PUNCT
ijpds-2950	22	1	cholesterol	cholesterol	NOUN
ijpds-2950	22	2	in	in	ADP
ijpds-2950	22	3	the	the	DET
ijpds-2950	22	4	brain	brain	NOUN
ijpds-2950	22	5	accounts	account	VERB
ijpds-2950	22	6	for	for	ADP
ijpds-2950	22	7	25	25	NUM
ijpds-2950	22	8	%	%	NOUN
ijpds-2950	22	9	of	of	ADP
ijpds-2950	22	10	the	the	DET
ijpds-2950	22	11	total	total	ADJ
ijpds-2950	22	12	body	body	NOUN
ijpds-2950	22	13	cholesterol	cholesterol	NOUN
ijpds-2950	22	14	[	[	X
ijpds-2950	22	15	5	5	NUM
ijpds-2950	22	16	]	]	PUNCT
ijpds-2950	22	17	.	.	PUNCT
ijpds-2950	23	1	about	about	ADV
ijpds-2950	23	2	70	70	NUM
ijpds-2950	23	3	%	%	NOUN
ijpds-2950	23	4	of	of	ADP
ijpds-2950	23	5	its	its	PRON
ijpds-2950	23	6	cholesterol	cholesterol	NOUN
ijpds-2950	23	7	is	be	AUX
ijpds-2950	23	8	there	there	PRON
ijpds-2950	23	9	in	in	ADP
ijpds-2950	23	10	the	the	DET
ijpds-2950	23	11	myelin	myelin	NOUN
ijpds-2950	23	12	,	,	PUNCT
ijpds-2950	23	13	20	20	NUM
ijpds-2950	23	14	%	%	NOUN
ijpds-2950	23	15	is	be	AUX
ijpds-2950	23	16	present	present	ADJ
ijpds-2950	23	17	in	in	ADP
ijpds-2950	23	18	the	the	DET
ijpds-2950	23	19	glial	glial	ADJ
ijpds-2950	23	20	cells	cell	NOUN
ijpds-2950	23	21	,	,	PUNCT
ijpds-2950	23	22	while	while	SCONJ
ijpds-2950	23	23	the	the	DET
ijpds-2950	23	24	remaining	remain	VERB
ijpds-2950	23	25	10	10	NUM
ijpds-2950	23	26	%	%	NOUN
ijpds-2950	23	27	is	be	AUX
ijpds-2950	23	28	present	present	ADJ
ijpds-2950	23	29	in	in	ADP
ijpds-2950	23	30	the	the	DET
ijpds-2950	23	31	neurons	neuron	NOUN
ijpds-2950	23	32	[	[	X
ijpds-2950	23	33	6	6	NUM
ijpds-2950	23	34	]	]	PUNCT
ijpds-2950	23	35	.	.	PUNCT
ijpds-2950	24	1	the	the	DET
ijpds-2950	24	2	cholesterol	cholesterol	NOUN
ijpds-2950	24	3	requirements	requirement	NOUN
ijpds-2950	24	4	in	in	ADP
ijpds-2950	24	5	the	the	DET
ijpds-2950	24	6	body	body	NOUN
ijpds-2950	24	7	are	be	AUX
ijpds-2950	24	8	met	meet	VERB
ijpds-2950	24	9	by	by	ADP
ijpds-2950	24	10	dietary	dietary	ADJ
ijpds-2950	24	11	intake	intake	NOUN
ijpds-2950	24	12	of	of	ADP
ijpds-2950	24	13	animal	animal	NOUN
ijpds-2950	24	14	fats	fat	NOUN
ijpds-2950	24	15	,	,	PUNCT
ijpds-2950	24	16	or	or	CCONJ
ijpds-2950	24	17	by	by	ADP
ijpds-2950	24	18	synthesis	synthesis	NOUN
ijpds-2950	24	19	.	.	PUNCT
ijpds-2950	25	1	cholesterol	cholesterol	NOUN
ijpds-2950	25	2	productiongets	productionget	NOUN
ijpds-2950	25	3	activated	activate	VERB
ijpds-2950	25	4	when	when	SCONJ
ijpds-2950	25	5	acetyl	acetyl	NOUN
ijpds-2950	25	6	-	-	PUNCT
ijpds-2950	25	7	coa	coa	NOUN
ijpds-2950	25	8	is	be	AUX
ijpds-2950	25	9	transformed	transform	VERB
ijpds-2950	25	10	into	into	ADP
ijpds-2950	25	11	3	3	NUM
ijpds-2950	25	12	-	-	PUNCT
ijpds-2950	25	13	hydroxy-3methylglutarylcoa	hydroxy-3methylglutarylcoa	NOUN
ijpds-2950	25	14	(	(	PUNCT
ijpds-2950	25	15	hmg	hmg	NOUN
ijpds-2950	25	16	-	-	PUNCT
ijpds-2950	25	17	coa	coa	NOUN
ijpds-2950	25	18	)	)	PUNCT
ijpds-2950	25	19	.	.	PUNCT
ijpds-2950	26	1	cholesterol	cholesterol	NOUN
ijpds-2950	26	2	is	be	AUX
ijpds-2950	26	3	formed	form	VERB
ijpds-2950	26	4	when	when	SCONJ
ijpds-2950	26	5	its	its	PRON
ijpds-2950	26	6	precursor	precursor	NOUN
ijpds-2950	26	7	lanosterol	lanosterol	NOUN
ijpds-2950	26	8	is	be	AUX
ijpds-2950	26	9	channeled	channel	VERB
ijpds-2950	26	10	into	into	ADP
ijpds-2950	26	11	either	either	CCONJ
ijpds-2950	26	12	the	the	DET
ijpds-2950	26	13	bloch	bloch	PROPN
ijpds-2950	26	14	pathway	pathway	NOUN
ijpds-2950	26	15	to	to	PART
ijpds-2950	26	16	generate	generate	VERB
ijpds-2950	26	17	desmosterol	desmosterol	NOUN
ijpds-2950	26	18	or	or	CCONJ
ijpds-2950	26	19	lathosterol	lathosterol	VERB
ijpds-2950	26	20	respectively	respectively	ADV
ijpds-2950	26	21	;	;	PUNCT
ijpds-2950	26	22	these	these	PRON
ijpds-2950	26	23	are	be	AUX
ijpds-2950	26	24	then	then	ADV
ijpds-2950	26	25	converted	convert	VERB
ijpds-2950	26	26	to	to	ADP
ijpds-2950	26	27	cholesterol	cholesterol	NOUN
ijpds-2950	26	28	[	[	X
ijpds-2950	26	29	7	7	NUM
ijpds-2950	26	30	]	]	PUNCT
ijpds-2950	26	31	.	.	PUNCT
ijpds-2950	27	1	cholesterol	cholesterol	NOUN
ijpds-2950	27	2	is	be	AUX
ijpds-2950	27	3	used	use	VERB
ijpds-2950	27	4	widely	widely	ADV
ijpds-2950	27	5	in	in	ADP
ijpds-2950	27	6	the	the	DET
ijpds-2950	27	7	body	body	NOUN
ijpds-2950	27	8	,	,	PUNCT
ijpds-2950	27	9	particularly	particularly	ADV
ijpds-2950	27	10	by	by	ADP
ijpds-2950	27	11	the	the	DET
ijpds-2950	27	12	cell	cell	NOUN
ijpds-2950	27	13	membrane	membrane	NOUN
ijpds-2950	27	14	structures	structure	NOUN
ijpds-2950	27	15	.	.	PUNCT
ijpds-2950	28	1	other	other	ADJ
ijpds-2950	28	2	important	important	ADJ
ijpds-2950	28	3	physiological	physiological	ADJ
ijpds-2950	28	4	functions	function	NOUN
ijpds-2950	28	5	include	include	VERB
ijpds-2950	28	6	the	the	DET
ijpds-2950	28	7	production	production	NOUN
ijpds-2950	28	8	of	of	ADP
ijpds-2950	28	9	bile	bile	NOUN
ijpds-2950	28	10	by	by	ADP
ijpds-2950	28	11	the	the	DET
ijpds-2950	28	12	liver	liver	NOUN
ijpds-2950	28	13	and	and	CCONJ
ijpds-2950	28	14	hormone	hormone	NOUN
ijpds-2950	28	15	synthesis	synthesis	NOUN
ijpds-2950	28	16	.	.	PUNCT
ijpds-2950	29	1	brain	brain	NOUN
ijpds-2950	29	2	cholesterol	cholesterol	NOUN
ijpds-2950	29	3	metabolism	metabolism	NOUN
ijpds-2950	29	4	is	be	AUX
ijpds-2950	29	5	different	different	ADJ
ijpds-2950	29	6	and	and	CCONJ
ijpds-2950	29	7	independent	independent	ADJ
ijpds-2950	29	8	from	from	ADP
ijpds-2950	29	9	that	that	PRON
ijpds-2950	29	10	of	of	ADP
ijpds-2950	29	11	peripheral	peripheral	ADJ
ijpds-2950	29	12	tissues	tissue	NOUN
ijpds-2950	29	13	,	,	PUNCT
ijpds-2950	29	14	due	due	ADP
ijpds-2950	29	15	to	to	ADP
ijpds-2950	29	16	the	the	DET
ijpds-2950	29	17	blood	blood	NOUN
ijpds-2950	29	18	–	–	PUNCT
ijpds-2950	29	19	brain	brain	NOUN
ijpds-2950	29	20	barrier	barrier	NOUN
ijpds-2950	29	21	(	(	PUNCT
ijpds-2950	29	22	bbb	bbb	NOUN
ijpds-2950	29	23	)	)	PUNCT
ijpds-2950	29	24	preventing	prevent	VERB
ijpds-2950	29	25	rapid	rapid	ADJ
ijpds-2950	29	26	transport	transport	NOUN
ijpds-2950	29	27	into	into	ADP
ijpds-2950	29	28	and	and	CCONJ
ijpds-2950	29	29	out	out	ADP
ijpds-2950	29	30	of	of	ADP
ijpds-2950	29	31	the	the	DET
ijpds-2950	29	32	brain	brain	NOUN
ijpds-2950	29	33	[	[	X
ijpds-2950	29	34	8	8	NUM
ijpds-2950	29	35	]	]	PUNCT
ijpds-2950	29	36	.	.	PUNCT
ijpds-2950	30	1	in	in	ADP
ijpds-2950	30	2	the	the	DET
ijpds-2950	30	3	adult	adult	NOUN
ijpds-2950	30	4	brain	brain	NOUN
ijpds-2950	30	5	,	,	PUNCT
ijpds-2950	30	6	cholesteroloriginate	cholesteroloriginate	NOUN
ijpds-2950	30	7	in	in	ADP
ijpds-2950	30	8	the	the	DET
ijpds-2950	30	9	form	form	NOUN
ijpds-2950	30	10	of	of	ADP
ijpds-2950	30	11	non	non	ADJ
ijpds-2950	30	12	-	-	ADJ
ijpds-2950	30	13	esterifies	esterifies	ADJ
ijpds-2950	30	14	form	form	NOUN
ijpds-2950	30	15	,	,	PUNCT
ijpds-2950	30	16	rest	rest	NOUN
ijpds-2950	30	17	being	be	AUX
ijpds-2950	30	18	in	in	ADP
ijpds-2950	30	19	the	the	DET
ijpds-2950	30	20	form	form	NOUN
ijpds-2950	30	21	of	of	ADP
ijpds-2950	30	22	desmosterol	desmosterol	NOUN
ijpds-2950	30	23	and	and	CCONJ
ijpds-2950	30	24	cholesteryl	cholesteryl	NOUN
ijpds-2950	30	25	esters	ester	NOUN
ijpds-2950	30	26	[	[	X
ijpds-2950	30	27	9	9	NUM
ijpds-2950	30	28	]	]	PUNCT
ijpds-2950	30	29	.	.	PUNCT
ijpds-2950	31	1	major	major	ADJ
ijpds-2950	31	2	part	part	NOUN
ijpds-2950	31	3	of	of	ADP
ijpds-2950	31	4	cholesterol	cholesterol	NOUN
ijpds-2950	31	5	(	(	PUNCT
ijpds-2950	31	6	about	about	ADV
ijpds-2950	31	7	70–80	70–80	NUM
ijpds-2950	31	8	%	%	NOUN
ijpds-2950	31	9	)	)	PUNCT
ijpds-2950	31	10	is	be	AUX
ijpds-2950	31	11	seen	see	VERB
ijpds-2950	31	12	in	in	ADP
ijpds-2950	31	13	the	the	DET
ijpds-2950	31	14	myelin	myelin	NOUN
ijpds-2950	31	15	sheaths	sheath	NOUN
ijpds-2950	31	16	formed	form	VERB
ijpds-2950	31	17	by	by	ADP
ijpds-2950	31	18	d	d	PROPN
ijpds-2950	31	19	mailto:suji648@yahoo.co.in	mailto:suji648@yahoo.co.in	NOUN
ijpds-2950	31	20	sujeetha	sujeetha	PROPN
ijpds-2950	31	21	&	&	CCONJ
ijpds-2950	31	22	anand	anand	PROPN
ijpds-2950	31	23	cholesterol	cholesterol	PROPN
ijpds-2950	31	24	and	and	CCONJ
ijpds-2950	31	25	alzheimer	alzheimer	PROPN
ijpds-2950	31	26	’s	’s	PART
ijpds-2950	31	27	vol	vol	NOUN
ijpds-2950	31	28	1	1	NUM
ijpds-2950	31	29	|	|	ADV
ijpds-2950	31	30	issue	issue	VERB
ijpds-2950	31	31	1	1	NUM
ijpds-2950	31	32	|	|	ADV
ijpds-2950	31	33	apr	apr	ADV
ijpds-2950	31	34	–	–	PUNCT
ijpds-2950	31	35	jun	jun	PROPN
ijpds-2950	31	36	2022	2022	NUM
ijpds-2950	31	37	indian	indian	PROPN
ijpds-2950	31	38	j	j	PROPN
ijpds-2950	31	39	pharm	pharm	PROPN
ijpds-2950	31	40	drug	drug	PROPN
ijpds-2950	31	41	studies	study	NOUN
ijpds-2950	31	42	|	|	ADV
ijpds-2950	31	43	11	11	NUM
ijpds-2950	31	44	oligodendrocyte	oligodendrocyte	NOUN
ijpds-2950	31	45	that	that	PRON
ijpds-2950	31	46	insulates	insulate	VERB
ijpds-2950	31	47	the	the	DET
ijpds-2950	31	48	axons	axon	NOUN
ijpds-2950	31	49	and	and	CCONJ
ijpds-2950	31	50	in	in	ADP
ijpds-2950	31	51	the	the	DET
ijpds-2950	31	52	plasma	plasma	NOUN
ijpds-2950	31	53	membranes	membrane	NOUN
ijpds-2950	31	54	of	of	ADP
ijpds-2950	31	55	astrocytes	astrocyte	NOUN
ijpds-2950	31	56	and	and	CCONJ
ijpds-2950	31	57	neurons	neuron	NOUN
ijpds-2950	31	58	,	,	PUNCT
ijpds-2950	31	59	where	where	SCONJ
ijpds-2950	31	60	it	it	PRON
ijpds-2950	31	61	maintains	maintain	VERB
ijpds-2950	31	62	cellular	cellular	ADJ
ijpds-2950	31	63	morphology	morphology	NOUN
ijpds-2950	31	64	,	,	PUNCT
ijpds-2950	31	65	plays	play	VERB
ijpds-2950	31	66	important	important	ADJ
ijpds-2950	31	67	roles	role	NOUN
ijpds-2950	31	68	in	in	ADP
ijpds-2950	31	69	lipid	lipid	ADJ
ijpds-2950	31	70	rafts	raft	NOUN
ijpds-2950	31	71	,	,	PUNCT
ijpds-2950	31	72	and	and	CCONJ
ijpds-2950	31	73	helps	help	VERB
ijpds-2950	31	74	in	in	ADP
ijpds-2950	31	75	the	the	DET
ijpds-2950	31	76	synaptic	synaptic	ADJ
ijpds-2950	31	77	transmission	transmission	NOUN
ijpds-2950	32	1	[	[	X
ijpds-2950	32	2	10	10	NUM
ijpds-2950	32	3	]	]	PUNCT
ijpds-2950	32	4	.	.	PUNCT
ijpds-2950	33	1	during	during	ADP
ijpds-2950	33	2	adolescence	adolescence	NOUN
ijpds-2950	33	3	,	,	PUNCT
ijpds-2950	33	4	the	the	DET
ijpds-2950	33	5	cholesterol	cholesterol	NOUN
ijpds-2950	33	6	turnover	turnover	NOUN
ijpds-2950	33	7	reduces	reduce	VERB
ijpds-2950	33	8	because	because	SCONJ
ijpds-2950	33	9	of	of	ADP
ijpds-2950	33	10	myelin	myelin	NOUN
ijpds-2950	33	11	sheath	sheath	NOUN
ijpds-2950	33	12	formation	formation	NOUN
ijpds-2950	33	13	with	with	ADP
ijpds-2950	33	14	the	the	DET
ijpds-2950	33	15	half	half	ADJ
ijpds-2950	33	16	-	-	PUNCT
ijpds-2950	33	17	life	life	NOUN
ijpds-2950	33	18	between	between	ADP
ijpds-2950	33	19	six	six	NUM
ijpds-2950	33	20	months	month	NOUN
ijpds-2950	33	21	and	and	CCONJ
ijpds-2950	33	22	five	five	NUM
ijpds-2950	33	23	years	year	NOUN
ijpds-2950	33	24	.	.	PUNCT
ijpds-2950	34	1	this	this	PRON
ijpds-2950	34	2	is	be	AUX
ijpds-2950	34	3	a	a	DET
ijpds-2950	34	4	contrast	contrast	NOUN
ijpds-2950	34	5	turnover	turnover	NOUN
ijpds-2950	34	6	that	that	PRON
ijpds-2950	34	7	occurs	occur	VERB
ijpds-2950	34	8	during	during	ADP
ijpds-2950	34	9	the	the	DET
ijpds-2950	34	10	general	general	ADJ
ijpds-2950	34	11	circulation	circulation	NOUN
ijpds-2950	34	12	[	[	X
ijpds-2950	34	13	6	6	NUM
ijpds-2950	34	14	]	]	PUNCT
ijpds-2950	34	15	.	.	PUNCT
ijpds-2950	35	1	the	the	DET
ijpds-2950	35	2	role	role	NOUN
ijpds-2950	35	3	of	of	ADP
ijpds-2950	35	4	lipid	lipid	ADJ
ijpds-2950	35	5	rafts	raft	NOUN
ijpds-2950	35	6	in	in	ADP
ijpds-2950	35	7	neurodegenerative	neurodegenerative	ADJ
ijpds-2950	35	8	diseases	disease	NOUN
ijpds-2950	35	9	lipid	lipid	NOUN
ijpds-2950	35	10	rafts	raft	NOUN
ijpds-2950	35	11	are	be	AUX
ijpds-2950	35	12	buoyant	buoyant	ADJ
ijpds-2950	35	13	membrane	membrane	NOUN
ijpds-2950	35	14	glycolipoprotein	glycolipoprotein	PROPN
ijpds-2950	35	15	micro	micro	NOUN
ijpds-2950	35	16	domains	domain	NOUN
ijpds-2950	35	17	rich	rich	ADJ
ijpds-2950	35	18	in	in	ADP
ijpds-2950	35	19	cholesterol	cholesterol	NOUN
ijpds-2950	35	20	and	and	CCONJ
ijpds-2950	35	21	sphingolipids	sphingolipid	NOUN
ijpds-2950	35	22	[	[	X
ijpds-2950	35	23	11	11	NUM
ijpds-2950	35	24	]	]	PUNCT
ijpds-2950	35	25	.	.	PUNCT
ijpds-2950	36	1	these	these	PRON
ijpds-2950	36	2	provide	provide	VERB
ijpds-2950	36	3	the	the	DET
ijpds-2950	36	4	frame	frame	NOUN
ijpds-2950	36	5	for	for	ADP
ijpds-2950	36	6	signaling	signal	VERB
ijpds-2950	36	7	molecules	molecule	NOUN
ijpds-2950	36	8	and	and	CCONJ
ijpds-2950	36	9	protein	protein	NOUN
ijpds-2950	36	10	transduction	transduction	NOUN
ijpds-2950	36	11	,	,	PUNCT
ijpds-2950	36	12	trafficking	trafficking	NOUN
ijpds-2950	36	13	and	and	CCONJ
ijpds-2950	36	14	immunoglobulin	immunoglobulin	NOUN
ijpds-2950	36	15	functions	function	NOUN
ijpds-2950	36	16	and	and	CCONJ
ijpds-2950	36	17	neurotransmitters	neurotransmitter	NOUN
ijpds-2950	36	18	[	[	X
ijpds-2950	36	19	12	12	NUM
ijpds-2950	36	20	]	]	PUNCT
ijpds-2950	36	21	.	.	PUNCT
ijpds-2950	37	1	lipid	lipid	PROPN
ijpds-2950	37	2	rafts	raft	NOUN
ijpds-2950	37	3	have	have	AUX
ijpds-2950	37	4	been	be	AUX
ijpds-2950	37	5	linked	link	VERB
ijpds-2950	37	6	to	to	ADP
ijpds-2950	37	7	various	various	ADJ
ijpds-2950	37	8	diseases	disease	NOUN
ijpds-2950	37	9	conditions	condition	NOUN
ijpds-2950	37	10	including	include	VERB
ijpds-2950	37	11	cardiovascular	cardiovascular	ADJ
ijpds-2950	37	12	disease	disease	NOUN
ijpds-2950	37	13	and	and	CCONJ
ijpds-2950	37	14	certain	certain	ADJ
ijpds-2950	37	15	cancers	cancer	NOUN
ijpds-2950	37	16	.	.	PUNCT
ijpds-2950	38	1	they	they	PRON
ijpds-2950	38	2	are	be	AUX
ijpds-2950	38	3	also	also	ADV
ijpds-2950	38	4	important	important	ADJ
ijpds-2950	38	5	for	for	ADP
ijpds-2950	38	6	the	the	DET
ijpds-2950	38	7	entry	entry	NOUN
ijpds-2950	38	8	,	,	PUNCT
ijpds-2950	38	9	replication	replication	NOUN
ijpds-2950	38	10	,	,	PUNCT
ijpds-2950	38	11	assembly	assembly	NOUN
ijpds-2950	38	12	,	,	PUNCT
ijpds-2950	38	13	and	and	CCONJ
ijpds-2950	38	14	budding	bud	VERB
ijpds-2950	38	15	of	of	ADP
ijpds-2950	38	16	various	various	ADJ
ijpds-2950	38	17	types	type	NOUN
ijpds-2950	38	18	of	of	ADP
ijpds-2950	38	19	viruses	virus	NOUN
ijpds-2950	38	20	[	[	X
ijpds-2950	38	21	13	13	NUM
ijpds-2950	38	22	]	]	PUNCT
ijpds-2950	38	23	.	.	PUNCT
ijpds-2950	39	1	some	some	DET
ijpds-2950	39	2	proteins	protein	NOUN
ijpds-2950	39	3	are	be	AUX
ijpds-2950	39	4	linked	link	VERB
ijpds-2950	39	5	with	with	ADP
ijpds-2950	39	6	lipid	lipid	ADJ
ijpds-2950	39	7	rafts	raft	NOUN
ijpds-2950	39	8	include	include	VERB
ijpds-2950	39	9	gpi	gpi	NOUN
ijpds-2950	39	10	-	-	PUNCT
ijpds-2950	39	11	anchored	anchor	VERB
ijpds-2950	39	12	proteins	protein	NOUN
ijpds-2950	39	13	,	,	PUNCT
ijpds-2950	39	14	src	src	NOUN
ijpds-2950	39	15	family	family	NOUN
ijpds-2950	39	16	kinases	kinase	NOUN
ijpds-2950	39	17	,	,	PUNCT
ijpds-2950	39	18	components	component	NOUN
ijpds-2950	39	19	of	of	ADP
ijpds-2950	39	20	the	the	DET
ijpds-2950	39	21	heterotrimeric	heterotrimeric	ADJ
ijpds-2950	39	22	g	g	NOUN
ijpds-2950	39	23	-	-	PUNCT
ijpds-2950	39	24	proteins	protein	NOUN
ijpds-2950	39	25	and	and	CCONJ
ijpds-2950	39	26	many	many	ADJ
ijpds-2950	39	27	of	of	ADP
ijpds-2950	39	28	the	the	DET
ijpds-2950	39	29	proteins	protein	NOUN
ijpds-2950	39	30	linked	link	VERB
ijpds-2950	39	31	to	to	ADP
ijpds-2950	39	32	ad	ad	NOUN
ijpds-2950	39	33	linked	link	VERB
ijpds-2950	39	34	with	with	ADP
ijpds-2950	39	35	the	the	DET
ijpds-2950	39	36	metabolism	metabolism	NOUN
ijpds-2950	39	37	of	of	ADP
ijpds-2950	39	38	app	app	NOUN
ijpds-2950	40	1	[	[	X
ijpds-2950	40	2	14	14	NUM
ijpds-2950	40	3	]	]	PUNCT
ijpds-2950	40	4	.	.	PUNCT
ijpds-2950	41	1	some	some	PRON
ijpds-2950	41	2	of	of	ADP
ijpds-2950	41	3	the	the	DET
ijpds-2950	41	4	later	late	ADJ
ijpds-2950	41	5	include	include	VERB
ijpds-2950	41	6	the	the	DET
ijpds-2950	41	7	γsecretase	γsecretase	ADJ
ijpds-2950	41	8	complex	complex	NOUN
ijpds-2950	41	9	(	(	PUNCT
ijpds-2950	41	10	processes	process	NOUN
ijpds-2950	41	11	over	over	ADP
ijpds-2950	41	12	20	20	NUM
ijpds-2950	41	13	proteins	protein	NOUN
ijpds-2950	41	14	,	,	PUNCT
ijpds-2950	41	15	including	include	VERB
ijpds-2950	41	16	γ	γ	NOUN
ijpds-2950	41	17	-	-	PUNCT
ijpds-2950	41	18	site	site	NOUN
ijpds-2950	41	19	cleavage	cleavage	NOUN
ijpds-2950	41	20	of	of	ADP
ijpds-2950	41	21	app	app	PROPN
ijpds-2950	41	22	)	)	PUNCT
ijpds-2950	41	23	,	,	PUNCT
ijpds-2950	41	24	bace-1	bace-1	PROPN
ijpds-2950	41	25	(	(	PUNCT
ijpds-2950	41	26	β	β	NOUN
ijpds-2950	41	27	-	-	PUNCT
ijpds-2950	41	28	site	site	NOUN
ijpds-2950	41	29	app	app	NOUN
ijpds-2950	41	30	cleaving	cleave	VERB
ijpds-2950	41	31	enzyme	enzyme	NOUN
ijpds-2950	41	32	,	,	PUNCT
ijpds-2950	41	33	the	the	DET
ijpds-2950	41	34	enzyme	enzyme	NOUN
ijpds-2950	41	35	responsible	responsible	ADJ
ijpds-2950	41	36	for	for	ADP
ijpds-2950	41	37	βsite	βsite	ADJ
ijpds-2950	41	38	app	app	NOUN
ijpds-2950	41	39	cleavage	cleavage	NOUN
ijpds-2950	41	40	)	)	PUNCT
ijpds-2950	41	41	,	,	PUNCT
ijpds-2950	41	42	adam10	adam10	NOUN
ijpds-2950	41	43	(	(	PUNCT
ijpds-2950	41	44	a	a	DET
ijpds-2950	41	45	disintegrin	disintegrin	NOUN
ijpds-2950	41	46	and	and	CCONJ
ijpds-2950	41	47	metalloprotease-10	metalloprotease-10	NOUN
ijpds-2950	41	48	,	,	PUNCT
ijpds-2950	41	49	enzyme	enzyme	NOUN
ijpds-2950	41	50	which	which	PRON
ijpds-2950	41	51	cleaves	cleave	VERB
ijpds-2950	41	52	app	app	NOUN
ijpds-2950	41	53	at	at	ADP
ijpds-2950	41	54	the	the	DET
ijpds-2950	41	55	α	α	NOUN
ijpds-2950	41	56	-	-	NOUN
ijpds-2950	41	57	site	site	NOUN
ijpds-2950	41	58	,	,	PUNCT
ijpds-2950	41	59	also	also	ADV
ijpds-2950	41	60	cleaves	cleave	VERB
ijpds-2950	41	61	tnf	tnf	PROPN
ijpds-2950	41	62	-	-	PUNCT
ijpds-2950	41	63	α	α	PROPN
ijpds-2950	41	64	and	and	CCONJ
ijpds-2950	41	65	e	e	NOUN
ijpds-2950	41	66	-	-	NOUN
ijpds-2950	41	67	cadherin	cadherin	NOUN
ijpds-2950	41	68	)	)	PUNCT
ijpds-2950	41	69	,	,	PUNCT
ijpds-2950	41	70	and	and	CCONJ
ijpds-2950	41	71	neprilysin	neprilysin	PROPN
ijpds-2950	41	72	,	,	PUNCT
ijpds-2950	41	73	an	an	DET
ijpds-2950	41	74	aβ	aβ	NOUN
ijpds-2950	41	75	-	-	PUNCT
ijpds-2950	41	76	degrading	degrade	VERB
ijpds-2950	41	77	enzyme	enzyme	NOUN
ijpds-2950	41	78	[	[	X
ijpds-2950	41	79	15	15	NUM
ijpds-2950	41	80	]	]	PUNCT
ijpds-2950	41	81	.	.	PUNCT
ijpds-2950	42	1	studies	study	NOUN
ijpds-2950	42	2	have	have	AUX
ijpds-2950	42	3	demonstrated	demonstrate	VERB
ijpds-2950	42	4	that	that	SCONJ
ijpds-2950	42	5	by	by	ADP
ijpds-2950	42	6	increasing	increase	VERB
ijpds-2950	42	7	the	the	DET
ijpds-2950	42	8	dietary	dietary	ADJ
ijpds-2950	42	9	cholesterol	cholesterol	NOUN
ijpds-2950	42	10	content	content	NOUN
ijpds-2950	42	11	,	,	PUNCT
ijpds-2950	42	12	aβ	aβ	DET
ijpds-2950	42	13	production	production	NOUN
ijpds-2950	42	14	can	can	AUX
ijpds-2950	42	15	be	be	AUX
ijpds-2950	42	16	elevated	elevate	VERB
ijpds-2950	43	1	[	[	X
ijpds-2950	43	2	16	16	NUM
ijpds-2950	43	3	]	]	PUNCT
ijpds-2950	43	4	.	.	PUNCT
ijpds-2950	44	1	in	in	ADP
ijpds-2950	44	2	animal	animal	NOUN
ijpds-2950	44	3	studies	study	NOUN
ijpds-2950	44	4	where	where	SCONJ
ijpds-2950	44	5	rabbits	rabbit	NOUN
ijpds-2950	44	6	were	be	AUX
ijpds-2950	44	7	placed	place	VERB
ijpds-2950	44	8	on	on	ADP
ijpds-2950	44	9	a	a	DET
ijpds-2950	44	10	highcholesterol	highcholesterol	NOUN
ijpds-2950	44	11	diet	diet	NOUN
ijpds-2950	44	12	,	,	PUNCT
ijpds-2950	44	13	a	a	DET
ijpds-2950	44	14	greater	great	ADJ
ijpds-2950	44	15	level	level	NOUN
ijpds-2950	44	16	of	of	ADP
ijpds-2950	44	17	brain	brain	NOUN
ijpds-2950	44	18	aβ	aβ	NOUN
ijpds-2950	44	19	accumulation	accumulation	NOUN
ijpds-2950	44	20	was	be	AUX
ijpds-2950	44	21	found	find	VERB
ijpds-2950	44	22	[	[	X
ijpds-2950	44	23	17	17	NUM
ijpds-2950	44	24	]	]	PUNCT
ijpds-2950	44	25	.	.	PUNCT
ijpds-2950	45	1	lim	lim	PROPN
ijpds-2950	45	2	et	et	PROPN
ijpds-2950	45	3	al	al	PROPN
ijpds-2950	45	4	.	.	PROPN
ijpds-2950	45	5	,	,	PUNCT
ijpds-2950	46	1	[	[	X
ijpds-2950	46	2	18	18	NUM
ijpds-2950	46	3	]	]	PUNCT
ijpds-2950	46	4	concluded	conclude	VERB
ijpds-2950	46	5	that	that	SCONJ
ijpds-2950	46	6	a	a	DET
ijpds-2950	46	7	high	high	ADJ
ijpds-2950	46	8	-	-	PUNCT
ijpds-2950	46	9	fat	fat	NOUN
ijpds-2950	46	10	and	and	CCONJ
ijpds-2950	46	11	highcholesterol	highcholesterol	NOUN
ijpds-2950	46	12	(	(	PUNCT
ijpds-2950	46	13	hfhc	hfhc	PROPN
ijpds-2950	46	14	)	)	PUNCT
ijpds-2950	46	15	diet	diet	NOUN
ijpds-2950	46	16	results	result	NOUN
ijpds-2950	46	17	in	in	ADP
ijpds-2950	46	18	increase	increase	NOUN
ijpds-2950	46	19	in	in	ADP
ijpds-2950	46	20	brain	brain	NOUN
ijpds-2950	46	21	cholesterol	cholesterol	NOUN
ijpds-2950	46	22	esters	ester	NOUN
ijpds-2950	46	23	,	,	PUNCT
ijpds-2950	46	24	these	these	DET
ijpds-2950	46	25	effects	effect	NOUN
ijpds-2950	46	26	were	be	AUX
ijpds-2950	46	27	seen	see	VERB
ijpds-2950	46	28	in	in	ADP
ijpds-2950	46	29	older	old	ADJ
ijpds-2950	46	30	apo	apo	PROPN
ijpds-2950	46	31	e	e	PROPN
ijpds-2950	46	32	e4	e4	PROPN
ijpds-2950	46	33	knock	knock	NOUN
ijpds-2950	46	34	-	-	PUNCT
ijpds-2950	46	35	in	in	ADP
ijpds-2950	46	36	mice	mouse	NOUN
ijpds-2950	46	37	compared	compare	VERB
ijpds-2950	46	38	to	to	ADP
ijpds-2950	46	39	apo	apo	PROPN
ijpds-2950	46	40	e	e	PROPN
ijpds-2950	46	41	e3	e3	NOUN
ijpds-2950	46	42	mice	mouse	NOUN
ijpds-2950	46	43	.	.	PUNCT
ijpds-2950	47	1	conversely	conversely	ADV
ijpds-2950	47	2	,	,	PUNCT
ijpds-2950	47	3	the	the	DET
ijpds-2950	47	4	reduction	reduction	NOUN
ijpds-2950	47	5	of	of	ADP
ijpds-2950	47	6	cell	cell	NOUN
ijpds-2950	47	7	membrane	membrane	NOUN
ijpds-2950	47	8	cholesterol	cholesterol	NOUN
ijpds-2950	47	9	has	have	AUX
ijpds-2950	47	10	been	be	AUX
ijpds-2950	47	11	shown	show	VERB
ijpds-2950	47	12	to	to	PART
ijpds-2950	47	13	reduce	reduce	VERB
ijpds-2950	47	14	γ	γ	NOUN
ijpds-2950	47	15	-	-	PUNCT
ijpds-2950	47	16	secretase	secretase	ADJ
ijpds-2950	47	17	activity	activity	NOUN
ijpds-2950	47	18	and	and	CCONJ
ijpds-2950	47	19	also	also	ADV
ijpds-2950	47	20	to	to	PART
ijpds-2950	47	21	increase	increase	VERB
ijpds-2950	47	22	the	the	DET
ijpds-2950	47	23	non	non	ADJ
ijpds-2950	47	24	-	-	ADJ
ijpds-2950	47	25	amyloidogenic	amyloidogenic	ADJ
ijpds-2950	47	26	α	α	NOUN
ijpds-2950	47	27	-	-	PUNCT
ijpds-2950	47	28	secretase	secretase	ADJ
ijpds-2950	47	29	cleavage	cleavage	NOUN
ijpds-2950	47	30	of	of	ADP
ijpds-2950	47	31	app	app	NOUN
ijpds-2950	47	32	[	[	X
ijpds-2950	47	33	19	19	NUM
ijpds-2950	47	34	,	,	PUNCT
ijpds-2950	47	35	20	20	NUM
ijpds-2950	47	36	]	]	PUNCT
ijpds-2950	47	37	.	.	PUNCT
ijpds-2950	48	1	studies	study	NOUN
ijpds-2950	48	2	have	have	AUX
ijpds-2950	48	3	shown	show	VERB
ijpds-2950	48	4	that	that	SCONJ
ijpds-2950	48	5	the	the	DET
ijpds-2950	48	6	membranes	membrane	NOUN
ijpds-2950	48	7	of	of	ADP
ijpds-2950	48	8	the	the	DET
ijpds-2950	48	9	lipid	lipid	NOUN
ijpds-2950	48	10	content	content	NOUN
ijpds-2950	48	11	raft	raft	NOUN
ijpds-2950	48	12	,	,	PUNCT
ijpds-2950	48	13	from	from	ADP
ijpds-2950	48	14	early	early	ADJ
ijpds-2950	48	15	-	-	PUNCT
ijpds-2950	48	16	stage	stage	NOUN
ijpds-2950	48	17	ad	ad	NOUN
ijpds-2950	48	18	brain	brain	NOUN
ijpds-2950	48	19	frontal	frontal	ADJ
ijpds-2950	48	20	and	and	CCONJ
ijpds-2950	48	21	entorhinal	entorhinal	ADJ
ijpds-2950	48	22	cortex	cortex	NOUN
ijpds-2950	48	23	tissue	tissue	NOUN
ijpds-2950	48	24	,	,	PUNCT
ijpds-2950	48	25	has	have	VERB
ijpds-2950	48	26	greater	great	ADJ
ijpds-2950	48	27	microviscosity	microviscosity	NOUN
ijpds-2950	48	28	which	which	PRON
ijpds-2950	48	29	correlated	correlate	VERB
ijpds-2950	48	30	with	with	ADP
ijpds-2950	48	31	bace-1	bace-1	PROPN
ijpds-2950	48	32	/	/	SYM
ijpds-2950	48	33	app	app	NOUN
ijpds-2950	48	34	interaction	interaction	NOUN
ijpds-2950	48	35	levels	level	NOUN
ijpds-2950	48	36	[	[	X
ijpds-2950	48	37	21	21	NUM
ijpds-2950	48	38	]	]	PUNCT
ijpds-2950	48	39	.	.	PUNCT
ijpds-2950	49	1	this	this	PRON
ijpds-2950	49	2	was	be	AUX
ijpds-2950	49	3	found	find	VERB
ijpds-2950	49	4	not	not	PART
ijpds-2950	49	5	to	to	PART
ijpds-2950	49	6	be	be	AUX
ijpds-2950	49	7	due	due	ADJ
ijpds-2950	49	8	to	to	ADP
ijpds-2950	49	9	increased	increase	VERB
ijpds-2950	49	10	cholesterol	cholesterol	NOUN
ijpds-2950	49	11	or	or	CCONJ
ijpds-2950	49	12	sphingomyelin	sphingomyelin	NOUN
ijpds-2950	49	13	levels	level	NOUN
ijpds-2950	49	14	,	,	PUNCT
ijpds-2950	49	15	but	but	CCONJ
ijpds-2950	49	16	due	due	ADP
ijpds-2950	49	17	to	to	ADP
ijpds-2950	49	18	a	a	DET
ijpds-2950	49	19	lower	low	ADJ
ijpds-2950	49	20	content	content	NOUN
ijpds-2950	49	21	of	of	ADP
ijpds-2950	49	22	unsaturated	unsaturated	ADJ
ijpds-2950	49	23	fats	fat	NOUN
ijpds-2950	49	24	[	[	X
ijpds-2950	49	25	14	14	NUM
ijpds-2950	49	26	]	]	PUNCT
ijpds-2950	49	27	.	.	PUNCT
ijpds-2950	50	1	this	this	PRON
ijpds-2950	50	2	adds	add	VERB
ijpds-2950	50	3	to	to	ADP
ijpds-2950	50	4	the	the	DET
ijpds-2950	50	5	evidence	evidence	NOUN
ijpds-2950	50	6	that	that	PRON
ijpds-2950	50	7	dyslipidaemia	dyslipidaemia	NOUN
ijpds-2950	50	8	is	be	AUX
ijpds-2950	50	9	central	central	ADJ
ijpds-2950	50	10	in	in	ADP
ijpds-2950	50	11	ad	ad	NOUN
ijpds-2950	50	12	neurodegeneration	neurodegeneration	NOUN
ijpds-2950	50	13	and	and	CCONJ
ijpds-2950	50	14	that	that	SCONJ
ijpds-2950	50	15	a	a	DET
ijpds-2950	50	16	diet	diet	NOUN
ijpds-2950	50	17	high	high	ADJ
ijpds-2950	50	18	in	in	ADP
ijpds-2950	50	19	polyunsaturated	polyunsaturated	ADJ
ijpds-2950	50	20	fatty	fatty	NOUN
ijpds-2950	50	21	acids	acid	NOUN
ijpds-2950	50	22	may	may	AUX
ijpds-2950	50	23	provide	provide	VERB
ijpds-2950	50	24	benefit	benefit	NOUN
ijpds-2950	50	25	in	in	ADP
ijpds-2950	50	26	slowing	slow	VERB
ijpds-2950	50	27	or	or	CCONJ
ijpds-2950	50	28	preventing	prevent	VERB
ijpds-2950	50	29	ad	ad	NOUN
ijpds-2950	50	30	pathogenesis	pathogenesis	NOUN
ijpds-2950	50	31	.	.	PUNCT
ijpds-2950	51	1	transgenic	transgenic	NOUN
ijpds-2950	51	2	ad	ad	NOUN
ijpds-2950	51	3	mouse	mouse	NOUN
ijpds-2950	51	4	models	model	NOUN
ijpds-2950	51	5	and	and	CCONJ
ijpds-2950	51	6	mathematical	mathematical	ADJ
ijpds-2950	51	7	modeling	modeling	NOUN
ijpds-2950	51	8	studies	study	NOUN
ijpds-2950	51	9	support	support	VERB
ijpds-2950	51	10	this	this	DET
ijpds-2950	51	11	theory	theory	NOUN
ijpds-2950	51	12	,	,	PUNCT
ijpds-2950	51	13	with	with	ADP
ijpds-2950	51	14	evidence	evidence	NOUN
ijpds-2950	51	15	suggesting	suggest	VERB
ijpds-2950	51	16	that	that	SCONJ
ijpds-2950	51	17	increasing	increase	VERB
ijpds-2950	51	18	the	the	DET
ijpds-2950	51	19	cholesterol	cholesterol	NOUN
ijpds-2950	51	20	and	and	CCONJ
ijpds-2950	51	21	long	long	ADJ
ijpds-2950	51	22	-	-	PUNCT
ijpds-2950	51	23	chain	chain	NOUN
ijpds-2950	51	24	polyunsaturated	polyunsaturate	VERB
ijpds-2950	51	25	fatty	fatty	NOUN
ijpds-2950	51	26	acid	acid	NOUN
ijpds-2950	51	27	(	(	PUNCT
ijpds-2950	51	28	mainly	mainly	ADV
ijpds-2950	51	29	dha	dha	PROPN
ijpds-2950	51	30	)	)	PUNCT
ijpds-2950	51	31	content	content	NOUN
ijpds-2950	51	32	of	of	ADP
ijpds-2950	51	33	membranes	membrane	NOUN
ijpds-2950	51	34	may	may	AUX
ijpds-2950	51	35	delay	delay	VERB
ijpds-2950	51	36	the	the	DET
ijpds-2950	51	37	onset	onset	NOUN
ijpds-2950	51	38	and/or	and/or	CCONJ
ijpds-2950	51	39	progression	progression	NOUN
ijpds-2950	51	40	of	of	ADP
ijpds-2950	51	41	ad	ad	NOUN
ijpds-2950	51	42	[	[	X
ijpds-2950	51	43	22	22	NUM
ijpds-2950	51	44	]	]	X
ijpds-2950	51	45	alzheimer	alzheimer	PROPN
ijpds-2950	51	46	’s	’s	PART
ijpds-2950	51	47	disease	disease	NOUN
ijpds-2950	51	48	ad	ad	NOUN
ijpds-2950	51	49	is	be	AUX
ijpds-2950	51	50	the	the	DET
ijpds-2950	51	51	most	most	ADV
ijpds-2950	51	52	common	common	ADJ
ijpds-2950	51	53	type	type	NOUN
ijpds-2950	51	54	of	of	ADP
ijpds-2950	51	55	dementia	dementia	NOUN
ijpds-2950	51	56	,	,	PUNCT
ijpds-2950	51	57	characterized	characterize	VERB
ijpds-2950	51	58	by	by	ADP
ijpds-2950	51	59	the	the	DET
ijpds-2950	51	60	progressive	progressive	ADJ
ijpds-2950	51	61	loss	loss	NOUN
ijpds-2950	51	62	of	of	ADP
ijpds-2950	51	63	memory	memory	NOUN
ijpds-2950	51	64	and	and	CCONJ
ijpds-2950	51	65	other	other	ADJ
ijpds-2950	51	66	cognitive	cognitive	ADJ
ijpds-2950	51	67	functions	function	NOUN
ijpds-2950	51	68	of	of	ADP
ijpds-2950	51	69	the	the	DET
ijpds-2950	51	70	brain	brain	NOUN
ijpds-2950	51	71	.	.	PUNCT
ijpds-2950	52	1	an	an	DET
ijpds-2950	52	2	affected	affected	ADJ
ijpds-2950	52	3	individual	individual	NOUN
ijpds-2950	52	4	gradually	gradually	ADV
ijpds-2950	52	5	becomes	become	VERB
ijpds-2950	52	6	totally	totally	ADV
ijpds-2950	52	7	dependent	dependent	ADJ
ijpds-2950	52	8	upon	upon	SCONJ
ijpds-2950	52	9	others	other	NOUN
ijpds-2950	52	10	,	,	PUNCT
ijpds-2950	52	11	culminating	culminate	VERB
ijpds-2950	52	12	in	in	ADP
ijpds-2950	52	13	their	their	PRON
ijpds-2950	52	14	death	death	NOUN
ijpds-2950	52	15	approximately	approximately	ADV
ijpds-2950	52	16	3	3	NUM
ijpds-2950	52	17	–	–	PUNCT
ijpds-2950	52	18	10	10	NUM
ijpds-2950	52	19	years	year	NOUN
ijpds-2950	52	20	after	after	ADP
ijpds-2950	52	21	diagnosis	diagnosis	NOUN
ijpds-2950	52	22	[	[	X
ijpds-2950	52	23	23	23	NUM
ijpds-2950	52	24	]	]	PUNCT
ijpds-2950	52	25	.	.	PUNCT
ijpds-2950	53	1	the	the	DET
ijpds-2950	53	2	neurodegenerative	neurodegenerative	ADJ
ijpds-2950	53	3	changes	change	NOUN
ijpds-2950	53	4	that	that	PRON
ijpds-2950	53	5	are	be	AUX
ijpds-2950	53	6	characteristic	characteristic	ADJ
ijpds-2950	53	7	of	of	ADP
ijpds-2950	53	8	an	an	DET
ijpds-2950	53	9	ad	ad	NOUN
ijpds-2950	53	10	brain	brain	NOUN
ijpds-2950	53	11	include	include	VERB
ijpds-2950	53	12	widespread	widespread	ADJ
ijpds-2950	53	13	synaptic	synaptic	ADJ
ijpds-2950	53	14	and	and	CCONJ
ijpds-2950	53	15	neuronal	neuronal	ADJ
ijpds-2950	53	16	loss	loss	NOUN
ijpds-2950	53	17	,	,	PUNCT
ijpds-2950	53	18	the	the	DET
ijpds-2950	53	19	accumulation	accumulation	NOUN
ijpds-2950	53	20	of	of	ADP
ijpds-2950	53	21	extracellular	extracellular	ADJ
ijpds-2950	53	22	aβ	aβ	NOUN
ijpds-2950	53	23	fibrils	fibril	NOUN
ijpds-2950	53	24	and	and	CCONJ
ijpds-2950	53	25	plaques	plaque	NOUN
ijpds-2950	53	26	,	,	PUNCT
ijpds-2950	53	27	intracellular	intracellular	ADJ
ijpds-2950	53	28	neurofibrillary	neurofibrillary	ADJ
ijpds-2950	53	29	tangles	tangle	NOUN
ijpds-2950	53	30	(	(	PUNCT
ijpds-2950	53	31	nft	nft	PROPN
ijpds-2950	53	32	)	)	PUNCT
ijpds-2950	53	33	composed	compose	VERB
ijpds-2950	53	34	of	of	ADP
ijpds-2950	53	35	hyperphosphorylated	hyperphosphorylated	ADJ
ijpds-2950	53	36	tau	tau	PROPN
ijpds-2950	53	37	filaments	filament	NOUN
ijpds-2950	53	38	,	,	PUNCT
ijpds-2950	53	39	microglial	microglial	ADJ
ijpds-2950	53	40	infiltration	infiltration	NOUN
ijpds-2950	53	41	,	,	PUNCT
ijpds-2950	53	42	and	and	CCONJ
ijpds-2950	53	43	brain	brain	NOUN
ijpds-2950	53	44	atrophy	atrophy	NOUN
ijpds-2950	53	45	,	,	PUNCT
ijpds-2950	53	46	particularly	particularly	ADV
ijpds-2950	53	47	in	in	ADP
ijpds-2950	53	48	the	the	DET
ijpds-2950	53	49	regions	region	NOUN
ijpds-2950	53	50	important	important	ADJ
ijpds-2950	53	51	for	for	ADP
ijpds-2950	53	52	memory	memory	NOUN
ijpds-2950	53	53	,	,	PUNCT
ijpds-2950	53	54	such	such	ADJ
ijpds-2950	53	55	as	as	ADP
ijpds-2950	53	56	the	the	DET
ijpds-2950	53	57	hippocampus	hippocampus	NOUN
ijpds-2950	53	58	,	,	PUNCT
ijpds-2950	53	59	amygdala	amygdala	NOUN
ijpds-2950	53	60	,	,	PUNCT
ijpds-2950	53	61	and	and	CCONJ
ijpds-2950	53	62	frontal	frontal	ADJ
ijpds-2950	53	63	cortex	cortex	NOUN
ijpds-2950	53	64	[	[	X
ijpds-2950	53	65	24	24	NUM
ijpds-2950	53	66	]	]	PUNCT
ijpds-2950	53	67	.	.	PUNCT
ijpds-2950	54	1	genetic	genetic	ADJ
ijpds-2950	54	2	mutations	mutation	NOUN
ijpds-2950	54	3	in	in	ADP
ijpds-2950	54	4	genes	gene	NOUN
ijpds-2950	54	5	whose	whose	DET
ijpds-2950	54	6	proteins	protein	NOUN
ijpds-2950	54	7	are	be	AUX
ijpds-2950	54	8	involved	involve	VERB
ijpds-2950	54	9	in	in	ADP
ijpds-2950	54	10	the	the	DET
ijpds-2950	54	11	processing	processing	NOUN
ijpds-2950	54	12	of	of	ADP
ijpds-2950	54	13	the	the	DET
ijpds-2950	54	14	app	app	NOUN
ijpds-2950	54	15	to	to	ADP
ijpds-2950	54	16	aβ	aβ	NOUN
ijpds-2950	54	17	peptides	peptide	NOUN
ijpds-2950	54	18	,	,	PUNCT
ijpds-2950	54	19	such	such	ADJ
ijpds-2950	54	20	ps1	ps1	NOUN
ijpds-2950	54	21	and	and	CCONJ
ijpds-2950	54	22	ps2	ps2	PROPN
ijpds-2950	54	23	,	,	PUNCT
ijpds-2950	54	24	as	as	ADV
ijpds-2950	54	25	well	well	ADV
ijpds-2950	54	26	as	as	ADP
ijpds-2950	54	27	ad	ad	NOUN
ijpds-2950	54	28	-	-	PUNCT
ijpds-2950	54	29	related	relate	VERB
ijpds-2950	54	30	app	app	NOUN
ijpds-2950	54	31	mutations	mutation	NOUN
ijpds-2950	54	32	,	,	PUNCT
ijpds-2950	54	33	are	be	AUX
ijpds-2950	54	34	predisposing	predispose	VERB
ijpds-2950	54	35	risk	risk	NOUN
ijpds-2950	54	36	factors	factor	NOUN
ijpds-2950	54	37	for	for	ADP
ijpds-2950	54	38	ad	ad	NOUN
ijpds-2950	54	39	.	.	PUNCT
ijpds-2950	55	1	however	however	ADV
ijpds-2950	55	2	,	,	PUNCT
ijpds-2950	55	3	these	these	DET
ijpds-2950	55	4	mutations	mutation	NOUN
ijpds-2950	55	5	are	be	AUX
ijpds-2950	55	6	involved	involve	VERB
ijpds-2950	55	7	only	only	ADV
ijpds-2950	55	8	in	in	ADP
ijpds-2950	55	9	earlyonset	earlyonset	ADJ
ijpds-2950	55	10	familial	familial	ADJ
ijpds-2950	55	11	alzheimer	alzheimer	PROPN
ijpds-2950	55	12	’s	’s	PART
ijpds-2950	55	13	disease	disease	NOUN
ijpds-2950	55	14	(	(	PUNCT
ijpds-2950	55	15	eoad	eoad	NOUN
ijpds-2950	55	16	)	)	PUNCT
ijpds-2950	55	17	which	which	PRON
ijpds-2950	55	18	occurs	occur	VERB
ijpds-2950	55	19	before	before	ADP
ijpds-2950	55	20	age	age	NOUN
ijpds-2950	55	21	65	65	NUM
ijpds-2950	55	22	,	,	PUNCT
ijpds-2950	55	23	but	but	CCONJ
ijpds-2950	55	24	sometimes	sometimes	ADV
ijpds-2950	55	25	as	as	ADV
ijpds-2950	55	26	young	young	ADJ
ijpds-2950	55	27	as	as	ADP
ijpds-2950	55	28	30	30	NUM
ijpds-2950	55	29	.	.	PUNCT
ijpds-2950	56	1	these	these	DET
ijpds-2950	56	2	cases	case	NOUN
ijpds-2950	56	3	are	be	AUX
ijpds-2950	56	4	relatively	relatively	ADV
ijpds-2950	56	5	rare	rare	ADJ
ijpds-2950	56	6	and	and	CCONJ
ijpds-2950	56	7	account	account	VERB
ijpds-2950	56	8	for	for	ADP
ijpds-2950	56	9	less	less	ADJ
ijpds-2950	56	10	than	than	ADP
ijpds-2950	56	11	5	5	NUM
ijpds-2950	56	12	%	%	NOUN
ijpds-2950	56	13	of	of	ADP
ijpds-2950	56	14	all	all	DET
ijpds-2950	56	15	ad	ad	NOUN
ijpds-2950	56	16	cases	case	NOUN
ijpds-2950	56	17	[	[	X
ijpds-2950	56	18	25	25	NUM
ijpds-2950	56	19	]	]	PUNCT
ijpds-2950	56	20	.	.	PUNCT
ijpds-2950	57	1	the	the	DET
ijpds-2950	57	2	main	main	ADJ
ijpds-2950	57	3	risk	risk	NOUN
ijpds-2950	57	4	factor	factor	NOUN
ijpds-2950	57	5	linked	link	VERB
ijpds-2950	57	6	to	to	ADP
ijpds-2950	57	7	the	the	DET
ijpds-2950	57	8	much	much	ADV
ijpds-2950	57	9	more	more	ADV
ijpds-2950	57	10	common	common	ADJ
ijpds-2950	57	11	late	late	ADJ
ijpds-2950	57	12	-	-	PUNCT
ijpds-2950	57	13	onset	onset	NOUN
ijpds-2950	57	14	form	form	NOUN
ijpds-2950	57	15	of	of	ADP
ijpds-2950	57	16	alzheimer	alzheimer	PROPN
ijpds-2950	57	17	’s	’s	PART
ijpds-2950	57	18	disease	disease	NOUN
ijpds-2950	57	19	(	(	PUNCT
ijpds-2950	57	20	load	load	NOUN
ijpds-2950	57	21	)	)	PUNCT
ijpds-2950	57	22	is	be	AUX
ijpds-2950	57	23	apoe	apoe	ADJ
ijpds-2950	57	24	e4	e4	PROPN
ijpds-2950	57	25	allele	allele	NOUN
ijpds-2950	57	26	status	status	NOUN
ijpds-2950	57	27	.	.	PUNCT
ijpds-2950	58	1	other	other	ADJ
ijpds-2950	58	2	significant	significant	ADJ
ijpds-2950	58	3	risk	risk	NOUN
ijpds-2950	58	4	factors	factor	NOUN
ijpds-2950	58	5	include	include	VERB
ijpds-2950	58	6	dyslipidemia	dyslipidemia	NOUN
ijpds-2950	58	7	,	,	PUNCT
ijpds-2950	58	8	hypertension	hypertension	NOUN
ijpds-2950	58	9	,	,	PUNCT
ijpds-2950	58	10	obesity	obesity	NOUN
ijpds-2950	58	11	,	,	PUNCT
ijpds-2950	58	12	chronic	chronic	ADJ
ijpds-2950	58	13	inflammation	inflammation	NOUN
ijpds-2950	58	14	,	,	PUNCT
ijpds-2950	58	15	insulin	insulin	NOUN
ijpds-2950	58	16	resistance	resistance	NOUN
ijpds-2950	58	17	,	,	PUNCT
ijpds-2950	58	18	and	and	CCONJ
ijpds-2950	58	19	type	type	NOUN
ijpds-2950	58	20	2	2	NUM
ijpds-2950	58	21	diabetes	diabetes	NOUN
ijpds-2950	58	22	.	.	PUNCT
ijpds-2950	59	1	all	all	PRON
ijpds-2950	59	2	of	of	ADP
ijpds-2950	59	3	these	these	PRON
ijpds-2950	59	4	are	be	AUX
ijpds-2950	59	5	also	also	ADV
ijpds-2950	59	6	risk	risk	NOUN
ijpds-2950	59	7	factors	factor	NOUN
ijpds-2950	59	8	for	for	ADP
ijpds-2950	59	9	cardiovascular	cardiovascular	ADJ
ijpds-2950	59	10	disease	disease	NOUN
ijpds-2950	59	11	.	.	PUNCT
ijpds-2950	60	1	when	when	SCONJ
ijpds-2950	60	2	these	these	DET
ijpds-2950	60	3	conditions	condition	NOUN
ijpds-2950	60	4	occur	occur	VERB
ijpds-2950	60	5	together	together	ADV
ijpds-2950	60	6	,	,	PUNCT
ijpds-2950	60	7	this	this	PRON
ijpds-2950	60	8	is	be	AUX
ijpds-2950	60	9	termed	term	VERB
ijpds-2950	60	10	‘	'	PUNCT
ijpds-2950	60	11	metabolic	metabolic	ADJ
ijpds-2950	60	12	syndrome	syndrome	NOUN
ijpds-2950	60	13	’	'	PUNCT
ijpds-2950	61	1	[	[	X
ijpds-2950	61	2	28	28	NUM
ijpds-2950	61	3	,	,	PUNCT
ijpds-2950	61	4	29	29	NUM
ijpds-2950	61	5	]	]	PUNCT
ijpds-2950	61	6	.	.	PUNCT
ijpds-2950	62	1	it	it	PRON
ijpds-2950	62	2	is	be	AUX
ijpds-2950	62	3	believed	believe	VERB
ijpds-2950	62	4	that	that	SCONJ
ijpds-2950	62	5	metabolic	metabolic	NOUN
ijpds-2950	62	6	changes	change	NOUN
ijpds-2950	62	7	caused	cause	VERB
ijpds-2950	62	8	by	by	ADP
ijpds-2950	62	9	these	these	DET
ijpds-2950	62	10	conditions	condition	NOUN
ijpds-2950	62	11	lead	lead	VERB
ijpds-2950	62	12	to	to	ADP
ijpds-2950	62	13	a	a	DET
ijpds-2950	62	14	greater	great	ADJ
ijpds-2950	62	15	production	production	NOUN
ijpds-2950	62	16	or	or	CCONJ
ijpds-2950	62	17	reduced	reduced	ADJ
ijpds-2950	62	18	clearance	clearance	NOUN
ijpds-2950	62	19	(	(	PUNCT
ijpds-2950	62	20	or	or	CCONJ
ijpds-2950	62	21	both	both	PRON
ijpds-2950	62	22	)	)	PUNCT
ijpds-2950	62	23	of	of	ADP
ijpds-2950	62	24	aβ	aβ	DET
ijpds-2950	62	25	peptides	peptide	NOUN
ijpds-2950	62	26	.	.	PUNCT
ijpds-2950	63	1	many	many	ADJ
ijpds-2950	63	2	of	of	ADP
ijpds-2950	63	3	these	these	DET
ijpds-2950	63	4	risk	risk	NOUN
ijpds-2950	63	5	factors	factor	NOUN
ijpds-2950	63	6	can	can	AUX
ijpds-2950	63	7	be	be	AUX
ijpds-2950	63	8	prevented	prevent	VERB
ijpds-2950	63	9	by	by	ADP
ijpds-2950	63	10	altering	alter	VERB
ijpds-2950	63	11	diet	diet	NOUN
ijpds-2950	63	12	and	and	CCONJ
ijpds-2950	63	13	physical	physical	ADJ
ijpds-2950	63	14	exercise	exercise	NOUN
ijpds-2950	63	15	,	,	PUNCT
ijpds-2950	63	16	which	which	PRON
ijpds-2950	63	17	are	be	AUX
ijpds-2950	63	18	known	know	VERB
ijpds-2950	63	19	to	to	PART
ijpds-2950	63	20	reduce	reduce	VERB
ijpds-2950	63	21	the	the	DET
ijpds-2950	63	22	risk	risk	NOUN
ijpds-2950	63	23	of	of	ADP
ijpds-2950	63	24	cardiovascular	cardiovascular	ADJ
ijpds-2950	63	25	disease	disease	NOUN
ijpds-2950	63	26	.	.	PUNCT
ijpds-2950	64	1	there	there	PRON
ijpds-2950	64	2	is	be	VERB
ijpds-2950	64	3	a	a	DET
ijpds-2950	64	4	growing	grow	VERB
ijpds-2950	64	5	body	body	NOUN
ijpds-2950	64	6	of	of	ADP
ijpds-2950	64	7	evidence	evidence	NOUN
ijpds-2950	64	8	that	that	SCONJ
ijpds-2950	64	9	reducing	reduce	VERB
ijpds-2950	64	10	these	these	DET
ijpds-2950	64	11	same	same	ADJ
ijpds-2950	64	12	risk	risk	NOUN
ijpds-2950	64	13	factors	factor	NOUN
ijpds-2950	64	14	would	would	AUX
ijpds-2950	64	15	considerably	considerably	ADV
ijpds-2950	64	16	slow	slow	VERB
ijpds-2950	64	17	or	or	CCONJ
ijpds-2950	64	18	possibly	possibly	ADV
ijpds-2950	64	19	prevent	prevent	VERB
ijpds-2950	64	20	ad	ad	NOUN
ijpds-2950	64	21	pathogenesis	pathogenesis	NOUN
ijpds-2950	64	22	[	[	X
ijpds-2950	64	23	30	30	NUM
ijpds-2950	64	24	,	,	PUNCT
ijpds-2950	64	25	31	31	NUM
ijpds-2950	64	26	]	]	PUNCT
ijpds-2950	64	27	.	.	PUNCT
ijpds-2950	65	1	effect	effect	NOUN
ijpds-2950	65	2	of	of	ADP
ijpds-2950	65	3	amyloid	amyloid	NOUN
ijpds-2950	65	4	-	-	PUNCT
ijpds-2950	65	5	β	β	NOUN
ijpds-2950	65	6	on	on	ADP
ijpds-2950	65	7	lipid	lipid	ADJ
ijpds-2950	65	8	metabolism	metabolism	NOUN
ijpds-2950	65	9	it	it	PRON
ijpds-2950	65	10	has	have	AUX
ijpds-2950	65	11	been	be	AUX
ijpds-2950	65	12	suggested	suggest	VERB
ijpds-2950	65	13	that	that	SCONJ
ijpds-2950	65	14	app	app	NOUN
ijpds-2950	65	15	processing	processing	NOUN
ijpds-2950	65	16	affects	affect	VERB
ijpds-2950	65	17	cellular	cellular	ADJ
ijpds-2950	65	18	lipid	lipid	ADJ
ijpds-2950	65	19	metabolism	metabolism	NOUN
ijpds-2950	66	1	[	[	X
ijpds-2950	66	2	32	32	NUM
ijpds-2950	66	3	]	]	PUNCT
ijpds-2950	66	4	.	.	PUNCT
ijpds-2950	67	1	in	in	ADP
ijpds-2950	67	2	cultured	cultured	ADJ
ijpds-2950	67	3	neurons	neuron	NOUN
ijpds-2950	67	4	and	and	CCONJ
ijpds-2950	67	5	in	in	ADP
ijpds-2950	67	6	transgenic	transgenic	NOUN
ijpds-2950	67	7	mice	mouse	NOUN
ijpds-2950	67	8	,	,	PUNCT
ijpds-2950	67	9	aβ	aβ	NOUN
ijpds-2950	67	10	with	with	ADP
ijpds-2950	67	11	42	42	NUM
ijpds-2950	67	12	amino	amino	ADJ
ijpds-2950	67	13	acids	acid	NOUN
ijpds-2950	67	14	(	(	PUNCT
ijpds-2950	67	15	aβ42	aβ42	PROPN
ijpds-2950	67	16	)	)	PUNCT
ijpds-2950	67	17	can	can	AUX
ijpds-2950	67	18	activate	activate	VERB
ijpds-2950	67	19	neutral	neutral	ADJ
ijpds-2950	67	20	sphingomyelinases	sphingomyelinase	NOUN
ijpds-2950	67	21	and	and	CCONJ
ijpds-2950	67	22	down	down	ADP
ijpds-2950	67	23	regulate	regulate	VERB
ijpds-2950	67	24	sphingomyelin	sphingomyelin	NOUN
ijpds-2950	67	25	levels	level	NOUN
ijpds-2950	67	26	,	,	PUNCT
ijpds-2950	67	27	whereas	whereas	SCONJ
ijpds-2950	67	28	aβ40	aβ40	PROPN
ijpds-2950	67	29	reduces	reduce	VERB
ijpds-2950	67	30	de	de	X
ijpds-2950	67	31	novo	novo	NOUN
ijpds-2950	67	32	cholesterol	cholesterol	NOUN
ijpds-2950	67	33	synthesis	synthesis	NOUN
ijpds-2950	67	34	by	by	ADP
ijpds-2950	67	35	inhibiting	inhibit	VERB
ijpds-2950	67	36	the	the	DET
ijpds-2950	67	37	activity	activity	NOUN
ijpds-2950	67	38	of	of	ADP
ijpds-2950	67	39	hmg	hmg	NOUN
ijpds-2950	67	40	-	-	PUNCT
ijpds-2950	67	41	coa	coa	NOUN
ijpds-2950	67	42	reductase	reductase	NOUN
ijpds-2950	67	43	.	.	PUNCT
ijpds-2950	68	1	therefore	therefore	ADV
ijpds-2950	68	2	,	,	PUNCT
ijpds-2950	68	3	maintaining	maintain	VERB
ijpds-2950	68	4	lipid	lipid	NOUN
ijpds-2950	68	5	homeostasis	homeostasis	NOUN
ijpds-2950	68	6	could	could	AUX
ijpds-2950	68	7	be	be	AUX
ijpds-2950	68	8	a	a	DET
ijpds-2950	68	9	biological	biological	ADJ
ijpds-2950	68	10	function	function	NOUN
ijpds-2950	68	11	of	of	ADP
ijpds-2950	68	12	app	app	NOUN
ijpds-2950	68	13	processing	processing	NOUN
ijpds-2950	68	14	grimm	grimm	PROPN
ijpds-2950	68	15	et	et	PROPN
ijpds-2950	68	16	al	al	PROPN
ijpds-2950	68	17	.	.	PROPN
ijpds-2950	68	18	,	,	PUNCT
ijpds-2950	69	1	[	[	X
ijpds-2950	69	2	33	33	NUM
ijpds-2950	69	3	]	]	PUNCT
ijpds-2950	69	4	and	and	CCONJ
ijpds-2950	69	5	the	the	DET
ijpds-2950	69	6	pathological	pathological	ADJ
ijpds-2950	69	7	accumulation	accumulation	NOUN
ijpds-2950	69	8	of	of	ADP
ijpds-2950	69	9	aβ	aβ	PRON
ijpds-2950	69	10	could	could	AUX
ijpds-2950	69	11	lead	lead	VERB
ijpds-2950	69	12	to	to	ADP
ijpds-2950	69	13	abnormal	abnormal	ADJ
ijpds-2950	69	14	lipid	lipid	NOUN
ijpds-2950	69	15	metabolism	metabolism	NOUN
ijpds-2950	69	16	.	.	PUNCT
ijpds-2950	70	1	furthermore	furthermore	ADV
ijpds-2950	70	2	,	,	PUNCT
ijpds-2950	70	3	both	both	DET
ijpds-2950	70	4	studies	study	NOUN
ijpds-2950	70	5	in	in	ADP
ijpds-2950	70	6	vitro	vitro	X
ijpds-2950	70	7	and	and	CCONJ
ijpds-2950	70	8	in	in	ADP
ijpds-2950	70	9	ad	ad	NOUN
ijpds-2950	70	10	patients	patient	NOUN
ijpds-2950	70	11	suggest	suggest	VERB
ijpds-2950	70	12	that	that	SCONJ
ijpds-2950	70	13	aβ	aβ	NOUN
ijpds-2950	70	14	causes	cause	VERB
ijpds-2950	70	15	oxidative	oxidative	ADJ
ijpds-2950	70	16	stress	stress	NOUN
ijpds-2950	70	17	,	,	PUNCT
ijpds-2950	70	18	leading	lead	VERB
ijpds-2950	70	19	to	to	ADP
ijpds-2950	70	20	lipid	lipid	ADJ
ijpds-2950	70	21	oxidation	oxidation	NOUN
ijpds-2950	70	22	that	that	PRON
ijpds-2950	70	23	might	might	AUX
ijpds-2950	70	24	contribute	contribute	VERB
ijpds-2950	70	25	directly	directly	ADV
ijpds-2950	70	26	to	to	ADP
ijpds-2950	70	27	neurodegeneration	neurodegeneration	NOUN
ijpds-2950	70	28	[	[	X
ijpds-2950	70	29	32	32	NUM
ijpds-2950	70	30	]	]	PUNCT
ijpds-2950	70	31	studies	study	NOUN
ijpds-2950	70	32	also	also	ADV
ijpds-2950	70	33	suggest	suggest	VERB
ijpds-2950	70	34	that	that	SCONJ
ijpds-2950	70	35	aβ	aβ	PRON
ijpds-2950	70	36	induces	induce	VERB
ijpds-2950	70	37	ozonolysis	ozonolysis	NOUN
ijpds-2950	70	38	of	of	ADP
ijpds-2950	70	39	cholesterol	cholesterol	NOUN
ijpds-2950	70	40	,	,	PUNCT
ijpds-2950	70	41	leading	lead	VERB
ijpds-2950	70	42	to	to	ADP
ijpds-2950	70	43	the	the	DET
ijpds-2950	70	44	formation	formation	NOUN
ijpds-2950	70	45	of	of	ADP
ijpds-2950	70	46	peroxiderivatives	peroxiderivative	NOUN
ijpds-2950	70	47	that	that	PRON
ijpds-2950	70	48	accelerate	accelerate	VERB
ijpds-2950	70	49	aggregation	aggregation	NOUN
ijpds-2950	70	50	of	of	ADP
ijpds-2950	70	51	aβ	aβ	DET
ijpds-2950	70	52	monomers	monomer	NOUN
ijpds-2950	70	53	[	[	X
ijpds-2950	70	54	35	35	NUM
ijpds-2950	70	55	]	]	PUNCT
ijpds-2950	70	56	and	and	CCONJ
ijpds-2950	70	57	that	that	SCONJ
ijpds-2950	70	58	aβ	aβ	NOUN
ijpds-2950	70	59	oxidizes	oxidize	VERB
ijpds-2950	70	60	cholesterol	cholesterol	NOUN
ijpds-2950	70	61	at	at	ADP
ijpds-2950	70	62	positions	position	NOUN
ijpds-2950	70	63	of	of	ADP
ijpds-2950	70	64	7	7	NUM
ijpds-2950	70	65	-	-	PUNCT
ijpds-2950	70	66	β	β	NOUN
ijpds-2950	70	67	and	and	CCONJ
ijpds-2950	70	68	3	3	NUM
ijpds-2950	70	69	-	-	SYM
ijpds-2950	70	70	β	β	NOUN
ijpds-2950	70	71	,	,	PUNCT
ijpds-2950	70	72	thus	thus	ADV
ijpds-2950	70	73	leading	lead	VERB
ijpds-2950	70	74	to	to	ADP
ijpds-2950	70	75	h2o2	h2o2	NOUN
ijpds-2950	70	76	production	production	NOUN
ijpds-2950	70	77	[	[	X
ijpds-2950	70	78	36	36	NUM
ijpds-2950	70	79	]	]	PUNCT
ijpds-2950	70	80	.	.	PUNCT
ijpds-2950	71	1	therefore	therefore	ADV
ijpds-2950	71	2	,	,	PUNCT
ijpds-2950	71	3	sujeetha	sujeetha	PROPN
ijpds-2950	71	4	&	&	CCONJ
ijpds-2950	71	5	anand	anand	PROPN
ijpds-2950	71	6	cholesterol	cholesterol	PROPN
ijpds-2950	71	7	and	and	CCONJ
ijpds-2950	71	8	alzheimer	alzheimer	PROPN
ijpds-2950	71	9	’s	’s	PART
ijpds-2950	71	10	vol	vol	NOUN
ijpds-2950	71	11	1	1	NUM
ijpds-2950	71	12	|	|	ADV
ijpds-2950	71	13	issue	issue	VERB
ijpds-2950	71	14	1	1	NUM
ijpds-2950	71	15	|	|	ADV
ijpds-2950	71	16	apr	apr	ADV
ijpds-2950	71	17	–	–	PUNCT
ijpds-2950	71	18	jun	jun	PROPN
ijpds-2950	71	19	2022	2022	NUM
ijpds-2950	71	20	indian	indian	PROPN
ijpds-2950	71	21	j	j	PROPN
ijpds-2950	71	22	pharm	pharm	PROPN
ijpds-2950	71	23	drug	drug	PROPN
ijpds-2950	71	24	studies	study	NOUN
ijpds-2950	71	25	|	|	ADV
ijpds-2950	71	26	12	12	NUM
ijpds-2950	71	27	a	a	DET
ijpds-2950	71	28	deleterious	deleterious	ADJ
ijpds-2950	71	29	feedback	feedback	NOUN
ijpds-2950	71	30	loop	loop	NOUN
ijpds-2950	71	31	between	between	ADP
ijpds-2950	71	32	aβ	aβ	NOUN
ijpds-2950	71	33	accumulation	accumulation	NOUN
ijpds-2950	71	34	and	and	CCONJ
ijpds-2950	71	35	altered	alter	VERB
ijpds-2950	71	36	lipid	lipid	NOUN
ijpds-2950	71	37	metabolism	metabolism	NOUN
ijpds-2950	71	38	could	could	AUX
ijpds-2950	71	39	be	be	AUX
ijpds-2950	71	40	one	one	NUM
ijpds-2950	71	41	of	of	ADP
ijpds-2950	71	42	the	the	DET
ijpds-2950	71	43	molecular	molecular	ADJ
ijpds-2950	71	44	mechanisms	mechanism	NOUN
ijpds-2950	71	45	underlying	underlie	VERB
ijpds-2950	71	46	the	the	DET
ijpds-2950	71	47	link	link	NOUN
ijpds-2950	71	48	between	between	ADP
ijpds-2950	71	49	lipid	lipid	NOUN
ijpds-2950	71	50	disorders	disorder	NOUN
ijpds-2950	71	51	and	and	CCONJ
ijpds-2950	71	52	ad	ad	NOUN
ijpds-2950	71	53	.	.	PUNCT
ijpds-2950	72	1	cholesterol	cholesterol	NOUN
ijpds-2950	72	2	metabolism	metabolism	NOUN
ijpds-2950	72	3	-	-	PUNCT
ijpds-2950	72	4	related	relate	VERB
ijpds-2950	72	5	genes	gene	NOUN
ijpds-2950	72	6	and	and	CCONJ
ijpds-2950	72	7	alzheimer	alzheimer	PROPN
ijpds-2950	72	8	’s	’s	PART
ijpds-2950	72	9	disease	disease	NOUN
ijpds-2950	72	10	apo	apo	PROPN
ijpds-2950	72	11	e	e	PROPN
ijpds-2950	72	12	protein	protein	NOUN
ijpds-2950	72	13	plays	play	VERB
ijpds-2950	72	14	a	a	DET
ijpds-2950	72	15	central	central	ADJ
ijpds-2950	72	16	role	role	NOUN
ijpds-2950	72	17	in	in	ADP
ijpds-2950	72	18	lipid	lipid	NOUN
ijpds-2950	72	19	transport	transport	NOUN
ijpds-2950	72	20	while	while	SCONJ
ijpds-2950	72	21	possession	possession	NOUN
ijpds-2950	72	22	of	of	ADP
ijpds-2950	72	23	the	the	DET
ijpds-2950	72	24	apoe	apoe	ADJ
ijpds-2950	72	25	e	e	NOUN
ijpds-2950	72	26	4	4	NUM
ijpds-2950	72	27	allele	allele	NOUN
ijpds-2950	72	28	influences	influence	VERB
ijpds-2950	72	29	ad	ad	NOUN
ijpds-2950	72	30	risk	risk	NOUN
ijpds-2950	72	31	.	.	PUNCT
ijpds-2950	73	1	the	the	DET
ijpds-2950	73	2	human	human	ADJ
ijpds-2950	73	3	apoe	apoe	ADJ
ijpds-2950	73	4	gene	gene	NOUN
ijpds-2950	73	5	is	be	AUX
ijpds-2950	73	6	located	locate	VERB
ijpds-2950	73	7	on	on	ADP
ijpds-2950	73	8	chromosome	chromosome	NOUN
ijpds-2950	73	9	19	19	NUM
ijpds-2950	73	10	,	,	PUNCT
ijpds-2950	73	11	and	and	CCONJ
ijpds-2950	73	12	its	its	PRON
ijpds-2950	73	13	three	three	NUM
ijpds-2950	73	14	most	most	ADV
ijpds-2950	73	15	common	common	ADJ
ijpds-2950	73	16	alleles	allele	NOUN
ijpds-2950	73	17	are	be	AUX
ijpds-2950	73	18	designated	designate	VERB
ijpds-2950	73	19	e2	e2	PROPN
ijpds-2950	73	20	,	,	PUNCT
ijpds-2950	73	21	e3	e3	NOUN
ijpds-2950	73	22	and	and	CCONJ
ijpds-2950	73	23	e4(williams	e4(william	NOUN
ijpds-2950	73	24	et	et	PROPN
ijpds-2950	73	25	al	al	PROPN
ijpds-2950	73	26	.	.	PROPN
ijpds-2950	73	27	,	,	PUNCT
ijpds-2950	73	28	2020	2020	NUM
ijpds-2950	73	29	)	)	PUNCT
ijpds-2950	73	30	.	.	PUNCT
ijpds-2950	74	1	of	of	ADP
ijpds-2950	74	2	these	these	PRON
ijpds-2950	74	3	,	,	PUNCT
ijpds-2950	74	4	e3	e3	NOUN
ijpds-2950	74	5	is	be	AUX
ijpds-2950	74	6	the	the	DET
ijpds-2950	74	7	most	most	ADV
ijpds-2950	74	8	common	common	ADJ
ijpds-2950	74	9	allele	allele	NOUN
ijpds-2950	74	10	in	in	ADP
ijpds-2950	74	11	humans	human	NOUN
ijpds-2950	74	12	(	(	PUNCT
ijpds-2950	74	13	78	78	NUM
ijpds-2950	74	14	%	%	NOUN
ijpds-2950	74	15	)	)	PUNCT
ijpds-2950	74	16	followed	follow	VERB
ijpds-2950	74	17	by	by	ADP
ijpds-2950	74	18	e4	e4	PROPN
ijpds-2950	74	19	(	(	PUNCT
ijpds-2950	74	20	14	14	NUM
ijpds-2950	74	21	%	%	NOUN
ijpds-2950	74	22	)	)	PUNCT
ijpds-2950	74	23	,	,	PUNCT
ijpds-2950	74	24	then	then	ADV
ijpds-2950	74	25	e2	e2	PROPN
ijpds-2950	74	26	(	(	PUNCT
ijpds-2950	74	27	8	8	NUM
ijpds-2950	74	28	%	%	NOUN
ijpds-2950	74	29	)	)	PUNCT
ijpds-2950	74	30	.	.	PUNCT
ijpds-2950	75	1	however	however	ADV
ijpds-2950	75	2	,	,	PUNCT
ijpds-2950	75	3	it	it	PRON
ijpds-2950	75	4	is	be	AUX
ijpds-2950	75	5	usually	usually	ADV
ijpds-2950	75	6	apo	apo	PROPN
ijpds-2950	75	7	e	e	PROPN
ijpds-2950	75	8	e4	e4	PROPN
ijpds-2950	75	9	which	which	PRON
ijpds-2950	75	10	is	be	AUX
ijpds-2950	75	11	associated	associate	VERB
ijpds-2950	75	12	with	with	ADP
ijpds-2950	75	13	increased	increase	VERB
ijpds-2950	75	14	levels	level	NOUN
ijpds-2950	75	15	of	of	ADP
ijpds-2950	75	16	circulating	circulate	VERB
ijpds-2950	75	17	ldl	ldl	NOUN
ijpds-2950	75	18	cholesterol	cholesterol	NOUN
ijpds-2950	75	19	,	,	PUNCT
ijpds-2950	75	20	higher	high	ADJ
ijpds-2950	75	21	triglyceride	triglyceride	ADJ
ijpds-2950	75	22	levels	level	NOUN
ijpds-2950	75	23	,	,	PUNCT
ijpds-2950	75	24	and	and	CCONJ
ijpds-2950	75	25	a	a	DET
ijpds-2950	75	26	greater	great	ADJ
ijpds-2950	75	27	risk	risk	NOUN
ijpds-2950	75	28	of	of	ADP
ijpds-2950	75	29	coronary	coronary	ADJ
ijpds-2950	75	30	artery	artery	NOUN
ijpds-2950	75	31	disease	disease	NOUN
ijpds-2950	75	32	(	(	PUNCT
ijpds-2950	75	33	linton	linton	PROPN
ijpds-2950	75	34	et	et	PROPN
ijpds-2950	75	35	al	al	PROPN
ijpds-2950	75	36	.	.	PROPN
ijpds-2950	75	37	,	,	PUNCT
ijpds-2950	75	38	2019	2019	NUM
ijpds-2950	75	39	)	)	PUNCT
ijpds-2950	75	40	.	.	PUNCT
ijpds-2950	76	1	this	this	PRON
ijpds-2950	76	2	is	be	AUX
ijpds-2950	76	3	despite	despite	SCONJ
ijpds-2950	76	4	apo	apo	PROPN
ijpds-2950	76	5	e	e	PROPN
ijpds-2950	76	6	e4	e4	PROPN
ijpds-2950	76	7	having	have	VERB
ijpds-2950	76	8	higher	high	ADJ
ijpds-2950	76	9	affinity	affinity	NOUN
ijpds-2950	76	10	for	for	ADP
ijpds-2950	76	11	the	the	DET
ijpds-2950	76	12	ldl	ldl	NOUN
ijpds-2950	76	13	receptors	receptor	NOUN
ijpds-2950	76	14	than	than	ADP
ijpds-2950	76	15	apo	apo	NOUN
ijpds-2950	76	16	e	e	NOUN
ijpds-2950	76	17	e3	e3	NOUN
ijpds-2950	76	18	and	and	CCONJ
ijpds-2950	76	19	e2	e2	NOUN
ijpds-2950	76	20	,	,	PUNCT
ijpds-2950	76	21	and	and	CCONJ
ijpds-2950	76	22	increased	increase	VERB
ijpds-2950	76	23	levels	level	NOUN
ijpds-2950	76	24	of	of	ADP
ijpds-2950	76	25	lipoprotein	lipoprotein	ADJ
ijpds-2950	76	26	internalization	internalization	NOUN
ijpds-2950	76	27	[	[	X
ijpds-2950	76	28	37	37	NUM
ijpds-2950	76	29	,	,	PUNCT
ijpds-2950	76	30	38].the	38].the	DET
ijpds-2950	76	31	increased	increase	VERB
ijpds-2950	76	32	affinity	affinity	NOUN
ijpds-2950	76	33	of	of	ADP
ijpds-2950	76	34	apo	apo	PROPN
ijpds-2950	76	35	e	e	PROPN
ijpds-2950	76	36	e4	e4	PROPN
ijpds-2950	76	37	for	for	ADP
ijpds-2950	76	38	the	the	DET
ijpds-2950	76	39	ldl	ldl	NOUN
ijpds-2950	76	40	receptor	receptor	NOUN
ijpds-2950	76	41	in	in	ADP
ijpds-2950	76	42	the	the	DET
ijpds-2950	76	43	periphery	periphery	NOUN
ijpds-2950	76	44	may	may	AUX
ijpds-2950	76	45	be	be	AUX
ijpds-2950	76	46	a	a	DET
ijpds-2950	76	47	limiting	limit	VERB
ijpds-2950	76	48	factor	factor	NOUN
ijpds-2950	76	49	for	for	ADP
ijpds-2950	76	50	cellular	cellular	ADJ
ijpds-2950	76	51	processing	processing	NOUN
ijpds-2950	76	52	of	of	ADP
ijpds-2950	76	53	lipoproteins	lipoprotein	NOUN
ijpds-2950	76	54	,	,	PUNCT
ijpds-2950	76	55	for	for	SCONJ
ijpds-2950	76	56	it	it	PRON
ijpds-2950	76	57	has	have	AUX
ijpds-2950	76	58	been	be	AUX
ijpds-2950	76	59	observed	observe	VERB
ijpds-2950	76	60	that	that	SCONJ
ijpds-2950	76	61	apo	apo	PROPN
ijpds-2950	76	62	e	e	PROPN
ijpds-2950	76	63	e4	e4	PROPN
ijpds-2950	76	64	is	be	AUX
ijpds-2950	76	65	poorly	poorly	ADV
ijpds-2950	76	66	recycled	recycle	VERB
ijpds-2950	76	67	by	by	ADP
ijpds-2950	76	68	cells	cell	NOUN
ijpds-2950	76	69	,	,	PUNCT
ijpds-2950	76	70	yet	yet	ADV
ijpds-2950	76	71	is	be	AUX
ijpds-2950	76	72	readily	readily	ADV
ijpds-2950	76	73	internalized	internalize	VERB
ijpds-2950	76	74	which	which	PRON
ijpds-2950	76	75	results	result	VERB
ijpds-2950	76	76	in	in	ADP
ijpds-2950	76	77	raised	raise	VERB
ijpds-2950	76	78	intracellular	intracellular	ADJ
ijpds-2950	76	79	cholesterol	cholesterol	NOUN
ijpds-2950	76	80	levels	level	NOUN
ijpds-2950	76	81	[	[	X
ijpds-2950	76	82	39	39	NUM
ijpds-2950	76	83	]	]	PUNCT
ijpds-2950	76	84	.	.	PUNCT
ijpds-2950	77	1	apo	apo	PROPN
ijpds-2950	77	2	e	e	PROPN
ijpds-2950	77	3	in	in	ADP
ijpds-2950	77	4	the	the	DET
ijpds-2950	77	5	brain	brain	NOUN
ijpds-2950	77	6	whilst	whilst	SCONJ
ijpds-2950	77	7	apo	apo	PROPN
ijpds-2950	77	8	e	e	PROPN
ijpds-2950	77	9	is	be	AUX
ijpds-2950	77	10	clearly	clearly	ADV
ijpds-2950	77	11	a	a	DET
ijpds-2950	77	12	molecule	molecule	NOUN
ijpds-2950	77	13	of	of	ADP
ijpds-2950	77	14	great	great	ADJ
ijpds-2950	77	15	importance	importance	NOUN
ijpds-2950	77	16	in	in	ADP
ijpds-2950	77	17	the	the	DET
ijpds-2950	77	18	cns	cns	NOUN
ijpds-2950	77	19	,	,	PUNCT
ijpds-2950	77	20	it	it	PRON
ijpds-2950	77	21	is	be	AUX
ijpds-2950	77	22	not	not	PART
ijpds-2950	77	23	imported	import	VERB
ijpds-2950	77	24	from	from	ADP
ijpds-2950	77	25	the	the	DET
ijpds-2950	77	26	periphery	periphery	NOUN
ijpds-2950	77	27	[	[	X
ijpds-2950	77	28	40	40	NUM
ijpds-2950	77	29	]	]	PUNCT
ijpds-2950	77	30	where	where	SCONJ
ijpds-2950	77	31	the	the	DET
ijpds-2950	77	32	liver	liver	NOUN
ijpds-2950	77	33	produces	produce	VERB
ijpds-2950	77	34	it	it	PRON
ijpds-2950	77	35	in	in	ADP
ijpds-2950	77	36	the	the	DET
ijpds-2950	77	37	largest	large	ADJ
ijpds-2950	77	38	amounts	amount	NOUN
ijpds-2950	77	39	.	.	PUNCT
ijpds-2950	78	1	rather	rather	ADV
ijpds-2950	78	2	it	it	PRON
ijpds-2950	78	3	is	be	AUX
ijpds-2950	78	4	synthesized	synthesize	VERB
ijpds-2950	78	5	locally	locally	ADV
ijpds-2950	78	6	by	by	ADP
ijpds-2950	78	7	astrocytes	astrocyte	NOUN
ijpds-2950	78	8	in	in	ADP
ijpds-2950	78	9	significant	significant	ADJ
ijpds-2950	78	10	quantities	quantity	NOUN
ijpds-2950	78	11	[	[	X
ijpds-2950	78	12	41	41	NUM
ijpds-2950	78	13	]	]	PUNCT
ijpds-2950	78	14	.	.	PUNCT
ijpds-2950	79	1	lrp-1	lrp-1	PRON
ijpds-2950	79	2	is	be	AUX
ijpds-2950	79	3	primarily	primarily	ADV
ijpds-2950	79	4	expressed	express	VERB
ijpds-2950	79	5	in	in	ADP
ijpds-2950	79	6	neurons	neuron	NOUN
ijpds-2950	79	7	,	,	PUNCT
ijpds-2950	79	8	whereas	whereas	SCONJ
ijpds-2950	79	9	glial	glial	ADJ
ijpds-2950	79	10	cells	cell	NOUN
ijpds-2950	79	11	mostly	mostly	ADV
ijpds-2950	79	12	express	express	VERB
ijpds-2950	79	13	the	the	DET
ijpds-2950	79	14	ldl	ldl	NOUN
ijpds-2950	79	15	-	-	PUNCT
ijpds-2950	79	16	receptor	receptor	NOUN
ijpds-2950	80	1	[	[	X
ijpds-2950	80	2	42	42	NUM
ijpds-2950	80	3	]	]	PUNCT
ijpds-2950	80	4	.	.	PUNCT
ijpds-2950	81	1	these	these	DET
ijpds-2950	81	2	receptors	receptor	NOUN
ijpds-2950	81	3	(	(	PUNCT
ijpds-2950	81	4	particularly	particularly	ADV
ijpds-2950	81	5	lrp-1	lrp-1	NUM
ijpds-2950	81	6	)	)	PUNCT
ijpds-2950	81	7	are	be	AUX
ijpds-2950	81	8	not	not	PART
ijpds-2950	81	9	only	only	ADV
ijpds-2950	81	10	used	use	VERB
ijpds-2950	81	11	for	for	ADP
ijpds-2950	81	12	lipoprotein	lipoprotein	ADJ
ijpds-2950	81	13	metabolism	metabolism	NOUN
ijpds-2950	81	14	,	,	PUNCT
ijpds-2950	81	15	but	but	CCONJ
ijpds-2950	81	16	they	they	PRON
ijpds-2950	81	17	also	also	ADV
ijpds-2950	81	18	bind	bind	VERB
ijpds-2950	81	19	some	some	DET
ijpds-2950	81	20	proteins	protein	NOUN
ijpds-2950	81	21	involved	involve	VERB
ijpds-2950	81	22	in	in	ADP
ijpds-2950	81	23	brain	brain	NOUN
ijpds-2950	81	24	development	development	NOUN
ijpds-2950	81	25	(	(	PUNCT
ijpds-2950	81	26	e.g.	e.g.	ADV
ijpds-2950	81	27	sonic	sonic	ADJ
ijpds-2950	81	28	hedgehog	hedgehog	PROPN
ijpds-2950	81	29	,	,	PUNCT
ijpds-2950	81	30	wnt	wnt	NOUN
ijpds-2950	81	31	,	,	PUNCT
ijpds-2950	81	32	and	and	CCONJ
ijpds-2950	81	33	reelin	reelin	PROPN
ijpds-2950	81	34	)	)	PUNCT
ijpds-2950	81	35	,	,	PUNCT
ijpds-2950	81	36	as	as	ADV
ijpds-2950	81	37	well	well	ADV
ijpds-2950	81	38	as	as	ADP
ijpds-2950	81	39	proteases	protease	NOUN
ijpds-2950	81	40	,	,	PUNCT
ijpds-2950	81	41	protease	protease	NOUN
ijpds-2950	81	42	inhibitors	inhibitor	NOUN
ijpds-2950	81	43	,	,	PUNCT
ijpds-2950	81	44	vitamin	vitamin	NOUN
ijpds-2950	81	45	transporters	transporter	NOUN
ijpds-2950	81	46	,	,	PUNCT
ijpds-2950	81	47	and	and	CCONJ
ijpds-2950	81	48	proinflammatory	proinflammatory	ADJ
ijpds-2950	81	49	molecules	molecule	NOUN
ijpds-2950	81	50	[	[	X
ijpds-2950	81	51	43	43	NUM
ijpds-2950	81	52	]	]	PUNCT
ijpds-2950	81	53	.	.	PUNCT
ijpds-2950	82	1	receptor	receptor	NOUN
ijpds-2950	82	2	-	-	PUNCT
ijpds-2950	82	3	mediated	mediate	VERB
ijpds-2950	82	4	endocytosis	endocytosis	NOUN
ijpds-2950	82	5	transit	transit	NOUN
ijpds-2950	82	6	lipid	lipid	NOUN
ijpds-2950	82	7	particles	particle	NOUN
ijpds-2950	82	8	to	to	ADP
ijpds-2950	82	9	late	late	ADJ
ijpds-2950	82	10	endosomes	endosome	NOUN
ijpds-2950	82	11	.	.	PUNCT
ijpds-2950	83	1	immediately	immediately	ADV
ijpds-2950	83	2	after	after	ADP
ijpds-2950	83	3	endocytosis	endocytosis	NOUN
ijpds-2950	83	4	,	,	PUNCT
ijpds-2950	83	5	apo	apo	PROPN
ijpds-2950	83	6	e	e	PROPN
ijpds-2950	83	7	is	be	AUX
ijpds-2950	83	8	detached	detach	VERB
ijpds-2950	83	9	from	from	ADP
ijpds-2950	83	10	the	the	DET
ijpds-2950	83	11	lipid	lipid	NOUN
ijpds-2950	83	12	components	component	NOUN
ijpds-2950	83	13	and	and	CCONJ
ijpds-2950	83	14	is	be	AUX
ijpds-2950	83	15	not	not	PART
ijpds-2950	83	16	sent	send	VERB
ijpds-2950	83	17	to	to	ADP
ijpds-2950	83	18	lysosomes	lysosome	NOUN
ijpds-2950	83	19	but	but	CCONJ
ijpds-2950	83	20	recycled	recycle	VERB
ijpds-2950	83	21	back	back	ADV
ijpds-2950	83	22	to	to	ADP
ijpds-2950	83	23	the	the	DET
ijpds-2950	83	24	plasma	plasma	NOUN
ijpds-2950	83	25	membrane	membrane	NOUN
ijpds-2950	84	1	[	[	X
ijpds-2950	84	2	44	44	NUM
ijpds-2950	84	3	]	]	PUNCT
ijpds-2950	84	4	.	.	PUNCT
ijpds-2950	85	1	apoe	apoe	ADJ
ijpds-2950	85	2	4	4	NUM
ijpds-2950	85	3	and	and	CCONJ
ijpds-2950	85	4	alzheimer	alzheimer	PROPN
ijpds-2950	85	5	’s	’s	PART
ijpds-2950	85	6	disease	disease	NOUN
ijpds-2950	85	7	one	one	NUM
ijpds-2950	85	8	of	of	ADP
ijpds-2950	85	9	the	the	DET
ijpds-2950	85	10	strongest	strong	ADJ
ijpds-2950	85	11	genetic	genetic	ADJ
ijpds-2950	85	12	risk	risk	NOUN
ijpds-2950	85	13	factors	factor	NOUN
ijpds-2950	85	14	for	for	ADP
ijpds-2950	85	15	ad	ad	NOUN
ijpds-2950	85	16	risk	risk	NOUN
ijpds-2950	85	17	is	be	AUX
ijpds-2950	85	18	apoe	apoe	ADJ
ijpds-2950	85	19	e4	e4	PROPN
ijpds-2950	85	20	allele	allele	NOUN
ijpds-2950	85	21	,	,	PUNCT
ijpds-2950	85	22	the	the	DET
ijpds-2950	85	23	mechanisms	mechanism	NOUN
ijpds-2950	85	24	is	be	AUX
ijpds-2950	85	25	still	still	ADV
ijpds-2950	85	26	implicit	implicit	ADJ
ijpds-2950	85	27	.	.	PUNCT
ijpds-2950	86	1	a	a	DET
ijpds-2950	86	2	study	study	NOUN
ijpds-2950	86	3	that	that	PRON
ijpds-2950	86	4	examined	examine	VERB
ijpds-2950	86	5	the	the	DET
ijpds-2950	86	6	physical	physical	ADJ
ijpds-2950	86	7	distribution	distribution	NOUN
ijpds-2950	86	8	of	of	ADP
ijpds-2950	86	9	the	the	DET
ijpds-2950	86	10	resultant	resultant	NOUN
ijpds-2950	86	11	apoe	apoe	PROPN
ijpds-2950	86	12	e4	e4	PROPN
ijpds-2950	86	13	protein	protein	NOUN
ijpds-2950	86	14	shows	show	VERB
ijpds-2950	86	15	that	that	SCONJ
ijpds-2950	86	16	it	it	PRON
ijpds-2950	86	17	gravitates	gravitate	VERB
ijpds-2950	86	18	towards	towards	ADP
ijpds-2950	86	19	the	the	DET
ijpds-2950	86	20	larger	large	ADJ
ijpds-2950	86	21	,	,	PUNCT
ijpds-2950	86	22	less	less	ADV
ijpds-2950	86	23	dense	dense	ADJ
ijpds-2950	86	24	particles	particle	NOUN
ijpds-2950	86	25	of	of	ADP
ijpds-2950	86	26	cns	cns	NOUN
ijpds-2950	86	27	lipoprotein	lipoprotein	NOUN
ijpds-2950	86	28	whereas	whereas	SCONJ
ijpds-2950	86	29	apoe	apoe	PROPN
ijpds-2950	86	30	e2	e2	PROPN
ijpds-2950	86	31	and	and	CCONJ
ijpds-2950	86	32	apoe	apoe	ADJ
ijpds-2950	86	33	e3	e3	NOUN
ijpds-2950	86	34	tend	tend	VERB
ijpds-2950	86	35	to	to	PART
ijpds-2950	86	36	associate	associate	VERB
ijpds-2950	86	37	with	with	ADP
ijpds-2950	86	38	smaller	small	ADJ
ijpds-2950	86	39	,	,	PUNCT
ijpds-2950	86	40	denser	dense	ADJ
ijpds-2950	86	41	lipoprotein	lipoprotein	ADJ
ijpds-2950	86	42	fractions	fraction	NOUN
ijpds-2950	86	43	[	[	X
ijpds-2950	86	44	45	45	NUM
ijpds-2950	86	45	]	]	PUNCT
ijpds-2950	86	46	.	.	PUNCT
ijpds-2950	87	1	like	like	ADP
ijpds-2950	87	2	their	their	PRON
ijpds-2950	87	3	peripheral	peripheral	ADJ
ijpds-2950	87	4	counterparts	counterpart	NOUN
ijpds-2950	87	5	,	,	PUNCT
ijpds-2950	87	6	the	the	DET
ijpds-2950	87	7	cns	cns	NOUN
ijpds-2950	87	8	apoe	apoe	ADJ
ijpds-2950	87	9	proteins	protein	NOUN
ijpds-2950	87	10	have	have	VERB
ijpds-2950	87	11	differential	differential	ADJ
ijpds-2950	87	12	effects	effect	NOUN
ijpds-2950	87	13	,	,	PUNCT
ijpds-2950	87	14	where	where	SCONJ
ijpds-2950	87	15	apoe	apoe	PROPN
ijpds-2950	87	16	e2	e2	PROPN
ijpds-2950	87	17	and	and	CCONJ
ijpds-2950	87	18	apoe	apoe	ADJ
ijpds-2950	87	19	e3	e3	NOUN
ijpds-2950	87	20	appear	appear	VERB
ijpds-2950	87	21	to	to	PART
ijpds-2950	87	22	be	be	AUX
ijpds-2950	87	23	more	more	ADV
ijpds-2950	87	24	effective	effective	ADJ
ijpds-2950	87	25	than	than	ADP
ijpds-2950	87	26	apoe	apoe	ADP
ijpds-2950	87	27	e4	e4	PROPN
ijpds-2950	88	1	[	[	X
ijpds-2950	88	2	46	46	NUM
ijpds-2950	88	3	]	]	PUNCT
ijpds-2950	88	4	.	.	PUNCT
ijpds-2950	89	1	early	early	ADJ
ijpds-2950	89	2	studies	study	NOUN
ijpds-2950	89	3	showed	show	VERB
ijpds-2950	89	4	that	that	SCONJ
ijpds-2950	89	5	plasma	plasma	NOUN
ijpds-2950	89	6	levels	level	NOUN
ijpds-2950	89	7	of	of	ADP
ijpds-2950	89	8	apoe	apoe	NOUN
ijpds-2950	89	9	may	may	AUX
ijpds-2950	89	10	be	be	AUX
ijpds-2950	89	11	an	an	DET
ijpds-2950	89	12	important	important	ADJ
ijpds-2950	89	13	factor	factor	NOUN
ijpds-2950	89	14	in	in	ADP
ijpds-2950	89	15	ad	ad	NOUN
ijpds-2950	89	16	,	,	PUNCT
ijpds-2950	89	17	as	as	SCONJ
ijpds-2950	89	18	higher	high	ADJ
ijpds-2950	89	19	levels	level	NOUN
ijpds-2950	89	20	were	be	AUX
ijpds-2950	89	21	observed	observe	VERB
ijpds-2950	89	22	in	in	ADP
ijpds-2950	89	23	the	the	DET
ijpds-2950	89	24	plasma	plasma	NOUN
ijpds-2950	89	25	of	of	ADP
ijpds-2950	89	26	ad	ad	NOUN
ijpds-2950	89	27	individuals	individual	NOUN
ijpds-2950	89	28	relative	relative	ADJ
ijpds-2950	89	29	to	to	ADP
ijpds-2950	89	30	non	non	ADJ
ijpds-2950	89	31	-	-	ADJ
ijpds-2950	89	32	ad	ad	ADJ
ijpds-2950	89	33	individuals	individual	NOUN
ijpds-2950	89	34	[	[	X
ijpds-2950	89	35	47	47	NUM
ijpds-2950	89	36	,	,	PUNCT
ijpds-2950	89	37	48	48	NUM
ijpds-2950	89	38	]	]	PUNCT
ijpds-2950	89	39	.	.	PUNCT
ijpds-2950	90	1	other	other	ADJ
ijpds-2950	90	2	early	early	ADJ
ijpds-2950	90	3	studies	study	NOUN
ijpds-2950	90	4	suggested	suggest	VERB
ijpds-2950	90	5	that	that	SCONJ
ijpds-2950	90	6	polymorphisms	polymorphism	NOUN
ijpds-2950	90	7	in	in	ADP
ijpds-2950	90	8	the	the	DET
ijpds-2950	90	9	apoe	apoe	ADJ
ijpds-2950	90	10	promoter	promoter	NOUN
ijpds-2950	90	11	region	region	NOUN
ijpds-2950	90	12	may	may	AUX
ijpds-2950	90	13	influence	influence	VERB
ijpds-2950	90	14	the	the	DET
ijpds-2950	90	15	probability	probability	NOUN
ijpds-2950	90	16	of	of	ADP
ijpds-2950	90	17	developing	develop	VERB
ijpds-2950	90	18	ad	ad	NOUN
ijpds-2950	90	19	[	[	X
ijpds-2950	90	20	49	49	NUM
ijpds-2950	90	21	,	,	PUNCT
ijpds-2950	90	22	50	50	NUM
ijpds-2950	90	23	]	]	PUNCT
ijpds-2950	90	24	.	.	PUNCT
ijpds-2950	91	1	this	this	DET
ijpds-2950	91	2	region	region	NOUN
ijpds-2950	91	3	,	,	PUNCT
ijpds-2950	91	4	which	which	PRON
ijpds-2950	91	5	belongs	belong	VERB
ijpds-2950	91	6	to	to	ADP
ijpds-2950	91	7	the	the	DET
ijpds-2950	91	8	tata	tata	PROPN
ijpds-2950	91	9	box	box	PROPN
ijpds-2950	91	10	family	family	PROPN
ijpds-2950	91	11	,	,	PUNCT
ijpds-2950	91	12	regulates	regulate	VERB
ijpds-2950	91	13	the	the	DET
ijpds-2950	91	14	production	production	NOUN
ijpds-2950	91	15	of	of	ADP
ijpds-2950	91	16	apoe	apoe	ADJ
ijpds-2950	91	17	protein	protein	NOUN
ijpds-2950	91	18	where	where	SCONJ
ijpds-2950	91	19	a	a	DET
ijpds-2950	91	20	genotype	genotype	NOUN
ijpds-2950	91	21	of	of	ADP
ijpds-2950	91	22	-491tt	-491tt	PROPN
ijpds-2950	91	23	produces	produce	VERB
ijpds-2950	91	24	much	much	ADV
ijpds-2950	91	25	less	less	ADV
ijpds-2950	91	26	apoe	apoe	ADJ
ijpds-2950	91	27	than	than	ADP
ijpds-2950	91	28	-491at	-491at	PROPN
ijpds-2950	91	29	and	and	CCONJ
ijpds-2950	91	30	-491aa	-491aa	PROPN
ijpds-2950	91	31	.	.	PUNCT
ijpds-2950	92	1	the	the	DET
ijpds-2950	92	2	initial	initial	ADJ
ijpds-2950	92	3	studies	study	NOUN
ijpds-2950	92	4	demonstrated	demonstrate	VERB
ijpds-2950	92	5	that	that	SCONJ
ijpds-2950	92	6	the	the	DET
ijpds-2950	92	7	apoe	apoe	NOUN
ijpds-2950	92	8	-491at	-491at	NOUN
ijpds-2950	92	9	and	and	CCONJ
ijpds-2950	92	10	aa	aa	NOUN
ijpds-2950	92	11	genotypes	genotype	NOUN
ijpds-2950	92	12	lead	lead	VERB
ijpds-2950	92	13	to	to	ADP
ijpds-2950	92	14	increased	increase	VERB
ijpds-2950	92	15	risk	risk	NOUN
ijpds-2950	92	16	for	for	ADP
ijpds-2950	92	17	ad	ad	NOUN
ijpds-2950	92	18	independent	independent	NOUN
ijpds-2950	92	19	of	of	ADP
ijpds-2950	92	20	apoe	apoe	ADJ
ijpds-2950	92	21	allele	allele	NOUN
ijpds-2950	92	22	[	[	X
ijpds-2950	92	23	51	51	NUM
ijpds-2950	92	24	]	]	PUNCT
ijpds-2950	92	25	.	.	PUNCT
ijpds-2950	93	1	it	it	PRON
ijpds-2950	93	2	was	be	AUX
ijpds-2950	93	3	soon	soon	ADV
ijpds-2950	93	4	realized	realize	VERB
ijpds-2950	93	5	that	that	SCONJ
ijpds-2950	93	6	the	the	DET
ijpds-2950	93	7	risk	risk	NOUN
ijpds-2950	93	8	for	for	ADP
ijpds-2950	93	9	ad	ad	NOUN
ijpds-2950	93	10	may	may	AUX
ijpds-2950	93	11	be	be	AUX
ijpds-2950	93	12	compounded	compound	VERB
ijpds-2950	93	13	when	when	SCONJ
ijpds-2950	93	14	apoe	apoe	ADJ
ijpds-2950	93	15	e4	e4	PROPN
ijpds-2950	93	16	alleles	allele	NOUN
ijpds-2950	93	17	and	and	CCONJ
ijpds-2950	93	18	the	the	DET
ijpds-2950	93	19	491	491	NUM
ijpds-2950	93	20	aa	aa	NOUN
ijpds-2950	93	21	genotype	genotype	NOUN
ijpds-2950	93	22	are	be	AUX
ijpds-2950	93	23	combined	combine	VERB
ijpds-2950	93	24	[	[	X
ijpds-2950	93	25	42	42	NUM
ijpds-2950	93	26	]	]	PUNCT
ijpds-2950	93	27	.	.	PUNCT
ijpds-2950	94	1	these	these	DET
ijpds-2950	94	2	results	result	NOUN
ijpds-2950	94	3	suggested	suggest	VERB
ijpds-2950	94	4	that	that	SCONJ
ijpds-2950	94	5	the	the	DET
ijpds-2950	94	6	improved	improved	ADJ
ijpds-2950	94	7	production	production	NOUN
ijpds-2950	94	8	of	of	ADP
ijpds-2950	94	9	the	the	DET
ijpds-2950	94	10	apoe	apoe	ADJ
ijpds-2950	94	11	protein	protein	NOUN
ijpds-2950	94	12	may	may	AUX
ijpds-2950	94	13	boost	boost	VERB
ijpds-2950	94	14	disease	disease	NOUN
ijpds-2950	94	15	progression	progression	NOUN
ijpds-2950	94	16	but	but	CCONJ
ijpds-2950	94	17	did	do	AUX
ijpds-2950	94	18	not	not	PART
ijpds-2950	94	19	account	account	VERB
ijpds-2950	94	20	for	for	ADP
ijpds-2950	94	21	any	any	DET
ijpds-2950	94	22	mechanism	mechanism	NOUN
ijpds-2950	94	23	of	of	ADP
ijpds-2950	94	24	action	action	NOUN
ijpds-2950	94	25	in	in	ADP
ijpds-2950	94	26	ad	ad	NOUN
ijpds-2950	94	27	by	by	ADP
ijpds-2950	94	28	the	the	DET
ijpds-2950	94	29	apoe	apoe	ADJ
ijpds-2950	94	30	e4	e4	PROPN
ijpds-2950	94	31	protein	protein	NOUN
ijpds-2950	94	32	itself	itself	PRON
ijpds-2950	94	33	.	.	PUNCT
ijpds-2950	95	1	however	however	ADV
ijpds-2950	95	2	,	,	PUNCT
ijpds-2950	95	3	more	more	ADV
ijpds-2950	95	4	recent	recent	ADJ
ijpds-2950	95	5	studies	study	NOUN
ijpds-2950	95	6	now	now	ADV
ijpds-2950	95	7	suggest	suggest	VERB
ijpds-2950	95	8	that	that	SCONJ
ijpds-2950	95	9	low	low	ADJ
ijpds-2950	95	10	plasma	plasma	NOUN
ijpds-2950	95	11	apoe	apoe	NOUN
ijpds-2950	95	12	levels	level	NOUN
ijpds-2950	95	13	increase	increase	VERB
ijpds-2950	95	14	the	the	DET
ijpds-2950	95	15	risk	risk	NOUN
ijpds-2950	95	16	of	of	ADP
ijpds-2950	95	17	ad	ad	NOUN
ijpds-2950	95	18	[	[	X
ijpds-2950	95	19	53	53	NUM
ijpds-2950	95	20	]	]	PUNCT
ijpds-2950	95	21	.	.	PUNCT
ijpds-2950	96	1	furthermore	furthermore	ADV
ijpds-2950	96	2	,	,	PUNCT
ijpds-2950	96	3	baker	baker	PROPN
ijpds-2950	96	4	-	-	PUNCT
ijpds-2950	96	5	nigh	nigh	PROPN
ijpds-2950	96	6	et	et	PROPN
ijpds-2950	96	7	al	al	PROPN
ijpds-2950	96	8	.	.	PROPN
ijpds-2950	96	9	,	,	PUNCT
ijpds-2950	96	10	2016	2016	NUM
ijpds-2950	96	11	concluded	conclude	VERB
ijpds-2950	96	12	that	that	SCONJ
ijpds-2950	96	13	the	the	DET
ijpds-2950	96	14	levels	level	NOUN
ijpds-2950	96	15	of	of	ADP
ijpds-2950	96	16	aapo	aapo	PROPN
ijpds-2950	96	17	e	e	PROPN
ijpds-2950	96	18	and	and	CCONJ
ijpds-2950	96	19	cns	cns	PROPN
ijpds-2950	96	20	are	be	AUX
ijpds-2950	96	21	not	not	PART
ijpds-2950	96	22	correlated	correlate	VERB
ijpds-2950	96	23	but	but	CCONJ
ijpds-2950	96	24	it	it	PRON
ijpds-2950	96	25	is	be	AUX
ijpds-2950	96	26	well	well	ADV
ijpds-2950	96	27	correlates	correlate	VERB
ijpds-2950	96	28	csf	csf	ADJ
ijpds-2950	97	1	aβ	aβ	NOUN
ijpds-2950	97	2	levels	level	NOUN
ijpds-2950	97	3	which	which	PRON
ijpds-2950	97	4	are	be	AUX
ijpds-2950	97	5	more	more	ADV
ijpds-2950	97	6	relevant	relevant	ADJ
ijpds-2950	97	7	to	to	ADP
ijpds-2950	97	8	ad	ad	NOUN
ijpds-2950	97	9	risk	risk	NOUN
ijpds-2950	97	10	.	.	PUNCT
ijpds-2950	98	1	conclusion	conclusion	NOUN
ijpds-2950	98	2	reducing	reduce	VERB
ijpds-2950	98	3	the	the	DET
ijpds-2950	98	4	risk	risk	NOUN
ijpds-2950	98	5	of	of	ADP
ijpds-2950	98	6	ad	ad	NOUN
ijpds-2950	98	7	will	will	AUX
ijpds-2950	98	8	involve	involve	VERB
ijpds-2950	98	9	dietary	dietary	ADJ
ijpds-2950	98	10	changes	change	NOUN
ijpds-2950	98	11	and	and	CCONJ
ijpds-2950	98	12	healthy	healthy	ADJ
ijpds-2950	98	13	lifestyles	lifestyle	NOUN
ijpds-2950	98	14	that	that	PRON
ijpds-2950	98	15	can	can	AUX
ijpds-2950	98	16	reduce	reduce	VERB
ijpds-2950	98	17	the	the	DET
ijpds-2950	98	18	risk	risk	NOUN
ijpds-2950	98	19	of	of	ADP
ijpds-2950	98	20	dyslipidaemia	dyslipidaemia	NOUN
ijpds-2950	98	21	,	,	PUNCT
ijpds-2950	98	22	insulin	insulin	NOUN
ijpds-2950	98	23	resistance	resistance	NOUN
ijpds-2950	98	24	,	,	PUNCT
ijpds-2950	98	25	type	type	NOUN
ijpds-2950	98	26	2	2	NUM
ijpds-2950	98	27	diabetes	diabete	NOUN
ijpds-2950	98	28	,	,	PUNCT
ijpds-2950	98	29	cardiovascular	cardiovascular	ADJ
ijpds-2950	98	30	disease	disease	NOUN
ijpds-2950	98	31	,	,	PUNCT
ijpds-2950	98	32	and	and	CCONJ
ijpds-2950	98	33	chronic	chronic	ADJ
ijpds-2950	98	34	inflammation	inflammation	NOUN
ijpds-2950	98	35	,	,	PUNCT
ijpds-2950	98	36	which	which	PRON
ijpds-2950	98	37	are	be	AUX
ijpds-2950	98	38	all	all	PRON
ijpds-2950	98	39	known	know	VERB
ijpds-2950	98	40	risk	risk	NOUN
ijpds-2950	98	41	factors	factor	NOUN
ijpds-2950	98	42	for	for	ADP
ijpds-2950	98	43	ad	ad	NOUN
ijpds-2950	98	44	.	.	PUNCT
ijpds-2950	99	1	despite	despite	SCONJ
ijpds-2950	99	2	the	the	DET
ijpds-2950	99	3	many	many	ADJ
ijpds-2950	99	4	studies	study	NOUN
ijpds-2950	99	5	on	on	ADP
ijpds-2950	99	6	the	the	DET
ijpds-2950	99	7	influence	influence	NOUN
ijpds-2950	99	8	of	of	ADP
ijpds-2950	99	9	the	the	DET
ijpds-2950	99	10	apoe	apoe	PROPN
ijpds-2950	99	11	e4	e4	PROPN
ijpds-2950	99	12	allele	allele	NOUN
ijpds-2950	99	13	on	on	ADP
ijpds-2950	99	14	aβ	aβ	DET
ijpds-2950	99	15	aggregation	aggregation	NOUN
ijpds-2950	99	16	,	,	PUNCT
ijpds-2950	99	17	binding	binding	ADJ
ijpds-2950	99	18	,	,	PUNCT
ijpds-2950	99	19	and	and	CCONJ
ijpds-2950	99	20	clearance	clearance	NOUN
ijpds-2950	99	21	,	,	PUNCT
ijpds-2950	99	22	the	the	DET
ijpds-2950	99	23	overall	overall	ADJ
ijpds-2950	99	24	pathological	pathological	ADJ
ijpds-2950	99	25	effect	effect	NOUN
ijpds-2950	99	26	of	of	ADP
ijpds-2950	99	27	this	this	DET
ijpds-2950	99	28	allele	allele	NOUN
ijpds-2950	99	29	is	be	AUX
ijpds-2950	99	30	still	still	ADV
ijpds-2950	99	31	not	not	PART
ijpds-2950	99	32	known	know	VERB
ijpds-2950	99	33	.	.	PUNCT
ijpds-2950	100	1	it	it	PRON
ijpds-2950	100	2	is	be	AUX
ijpds-2950	100	3	hoped	hope	VERB
ijpds-2950	100	4	this	this	PRON
ijpds-2950	100	5	will	will	AUX
ijpds-2950	100	6	pave	pave	VERB
ijpds-2950	100	7	the	the	DET
ijpds-2950	100	8	way	way	NOUN
ijpds-2950	100	9	towards	towards	ADP
ijpds-2950	100	10	effective	effective	ADJ
ijpds-2950	100	11	treatments	treatment	NOUN
ijpds-2950	100	12	,	,	PUNCT
ijpds-2950	100	13	whilst	whilst	SCONJ
ijpds-2950	100	14	highlighting	highlight	VERB
ijpds-2950	100	15	the	the	DET
ijpds-2950	100	16	importance	importance	NOUN
ijpds-2950	100	17	of	of	ADP
ijpds-2950	100	18	preventing	prevent	VERB
ijpds-2950	100	19	dyslipidaemia	dyslipidaemia	NOUN
ijpds-2950	100	20	.	.	PUNCT
ijpds-2950	101	1	references	reference	NOUN
ijpds-2950	101	2	1	1	NUM
ijpds-2950	101	3	.	.	PUNCT
ijpds-2950	101	4	martín	martín	PROPN
ijpds-2950	101	5	mg	mg	PROPN
ijpds-2950	101	6	,	,	PUNCT
ijpds-2950	101	7	pfrieger	pfrieger	NOUN
ijpds-2950	101	8	f	f	PROPN
ijpds-2950	101	9	,	,	PUNCT
ijpds-2950	101	10	dotti	dotti	PROPN
ijpds-2950	101	11	cg	cg	PROPN
ijpds-2950	101	12	.	.	PUNCT
ijpds-2950	101	13	cholesterol	cholesterol	NOUN
ijpds-2950	101	14	in	in	ADP
ijpds-2950	101	15	brain	brain	NOUN
ijpds-2950	101	16	disease	disease	NOUN
ijpds-2950	101	17	:	:	PUNCT
ijpds-2950	101	18	sometimes	sometimes	ADV
ijpds-2950	101	19	determinant	determinant	ADJ
ijpds-2950	101	20	and	and	CCONJ
ijpds-2950	101	21	frequently	frequently	ADV
ijpds-2950	101	22	implicated	implicate	VERB
ijpds-2950	101	23	.	.	PUNCT
ijpds-2950	102	1	embo	embo	PROPN
ijpds-2950	102	2	reports	report	VERB
ijpds-2950	102	3	.	.	PUNCT
ijpds-2950	103	1	2014;15(10):1036	2014;15(10):1036	X
ijpds-2950	103	2	-	-	SYM
ijpds-2950	103	3	52	52	NUM
ijpds-2950	103	4	.	.	NOUN
ijpds-2950	104	1	2	2	X
ijpds-2950	104	2	.	.	X
ijpds-2950	104	3	chew	chew	PROPN
ijpds-2950	104	4	h	h	PROPN
ijpds-2950	104	5	,	,	PUNCT
ijpds-2950	104	6	solomon	solomon	PROPN
ijpds-2950	104	7	va	va	PROPN
ijpds-2950	104	8	,	,	PUNCT
ijpds-2950	104	9	fonteh	fonteh	PROPN
ijpds-2950	105	1	an	an	PROPN
ijpds-2950	105	2	.	.	PUNCT
ijpds-2950	105	3	involvement	involvement	NOUN
ijpds-2950	105	4	of	of	ADP
ijpds-2950	105	5	lipids	lipid	NOUN
ijpds-2950	105	6	in	in	ADP
ijpds-2950	105	7	alzheimer	alzheimer	PROPN
ijpds-2950	105	8	’s	’s	PART
ijpds-2950	105	9	disease	disease	NOUN
ijpds-2950	105	10	pathology	pathology	NOUN
ijpds-2950	105	11	and	and	CCONJ
ijpds-2950	105	12	potential	potential	ADJ
ijpds-2950	105	13	therapies	therapy	NOUN
ijpds-2950	105	14	.	.	PUNCT
ijpds-2950	106	1	front	front	ADJ
ijpds-2950	106	2	physiol	physiol	PROPN
ijpds-2950	106	3	.	.	PUNCT
ijpds-2950	107	1	2020:9;11:598	2020:9;11:598	NUM
ijpds-2950	107	2	.	.	PUNCT
ijpds-2950	108	1	3	3	X
ijpds-2950	108	2	.	.	X
ijpds-2950	108	3	petrie	petrie	PROPN
ijpds-2950	108	4	jr	jr	PROPN
ijpds-2950	108	5	,	,	PUNCT
ijpds-2950	108	6	guzik	guzik	NOUN
ijpds-2950	108	7	tj	tj	PROPN
ijpds-2950	108	8	,	,	PUNCT
ijpds-2950	108	9	touyz	touyz	PROPN
ijpds-2950	108	10	rm	rm	PROPN
ijpds-2950	108	11	.	.	PROPN
ijpds-2950	109	1	diabetes	diabetes	NOUN
ijpds-2950	109	2	,	,	PUNCT
ijpds-2950	109	3	hypertension	hypertension	NOUN
ijpds-2950	109	4	,	,	PUNCT
ijpds-2950	109	5	and	and	CCONJ
ijpds-2950	109	6	cardiovascular	cardiovascular	ADJ
ijpds-2950	109	7	disease	disease	NOUN
ijpds-2950	109	8	:	:	PUNCT
ijpds-2950	109	9	clinical	clinical	ADJ
ijpds-2950	109	10	insights	insight	NOUN
ijpds-2950	109	11	and	and	CCONJ
ijpds-2950	109	12	vascular	vascular	ADJ
ijpds-2950	109	13	mechanisms	mechanism	NOUN
ijpds-2950	109	14	.	.	PUNCT
ijpds-2950	110	1	canadian	canadian	PROPN
ijpds-2950	110	2	j	j	PROPN
ijpds-2950	110	3	of	of	ADP
ijpds-2950	110	4	cardiology	cardiology	NOUN
ijpds-2950	110	5	.	.	PUNCT
ijpds-2950	111	1	2018:1;34(5):575	2018:1;34(5):575	NUM
ijpds-2950	111	2	-	-	SYM
ijpds-2950	111	3	84	84	NUM
ijpds-2950	111	4	.	.	PUNCT
ijpds-2950	112	1	4	4	X
ijpds-2950	112	2	.	.	X
ijpds-2950	112	3	kao	kao	PROPN
ijpds-2950	112	4	yc	yc	PROPN
ijpds-2950	112	5	,	,	PUNCT
ijpds-2950	112	6	ho	ho	PROPN
ijpds-2950	112	7	pc	pc	PROPN
ijpds-2950	112	8	,	,	PUNCT
ijpds-2950	112	9	tu	tu	PROPN
ijpds-2950	112	10	yk	yk	PROPN
ijpds-2950	112	11	,	,	PUNCT
ijpds-2950	112	12	et	et	PROPN
ijpds-2950	112	13	al	al	PROPN
ijpds-2950	112	14	.	.	PROPN
ijpds-2950	113	1	lipids	lipids	PROPN
ijpds-2950	113	2	and	and	CCONJ
ijpds-2950	113	3	alzheimer	alzheimer	PROPN
ijpds-2950	113	4	’s	’s	PART
ijpds-2950	113	5	disease	disease	NOUN
ijpds-2950	113	6	.	.	PUNCT
ijpds-2950	114	1	international	international	PROPN
ijpds-2950	114	2	j	j	PROPN
ijpds-2950	114	3	mol	mol	ADP
ijpds-2950	114	4	sci	sci	PROPN
ijpds-2950	114	5	.	.	PUNCT
ijpds-2950	115	1	2020;21(4):1505	2020;21(4):1505	NUM
ijpds-2950	115	2	.	.	PUNCT
ijpds-2950	116	1	5	5	NUM
ijpds-2950	116	2	.	.	X
ijpds-2950	116	3	björkhem	björkhem	PROPN
ijpds-2950	116	4	i.	i.	PROPN
ijpds-2950	116	5	crossing	cross	VERB
ijpds-2950	116	6	the	the	DET
ijpds-2950	116	7	barrier	barrier	NOUN
ijpds-2950	116	8	:	:	PUNCT
ijpds-2950	116	9	oxysterols	oxysterol	VERB
ijpds-2950	116	10	as	as	ADP
ijpds-2950	116	11	cholesterol	cholesterol	NOUN
ijpds-2950	116	12	transporters	transporter	NOUN
ijpds-2950	116	13	and	and	CCONJ
ijpds-2950	116	14	metabolic	metabolic	NOUN
ijpds-2950	116	15	modulators	modulator	NOUN
ijpds-2950	116	16	in	in	ADP
ijpds-2950	116	17	the	the	DET
ijpds-2950	116	18	brain	brain	NOUN
ijpds-2950	116	19	.	.	PUNCT
ijpds-2950	117	1	j	j	PROPN
ijpds-2950	117	2	of	of	ADP
ijpds-2950	117	3	internal	internal	ADJ
ijpds-2950	117	4	medicine	medicine	NOUN
ijpds-2950	117	5	.	.	PUNCT
ijpds-2950	118	1	2006;260(6):493	2006;260(6):493	NUM
ijpds-2950	118	2	-	-	SYM
ijpds-2950	118	3	508	508	NUM
ijpds-2950	118	4	.	.	NOUN
ijpds-2950	119	1	6	6	NUM
ijpds-2950	119	2	.	.	X
ijpds-2950	120	1	zhang	zhang	PROPN
ijpds-2950	120	2	j	j	PROPN
ijpds-2950	120	3	and	and	CCONJ
ijpds-2950	120	4	liu	liu	PROPN
ijpds-2950	120	5	q.	q.	PROPN
ijpds-2950	120	6	cholesterol	cholesterol	PROPN
ijpds-2950	120	7	metabolism	metabolism	NOUN
ijpds-2950	120	8	and	and	CCONJ
ijpds-2950	120	9	homeostasis	homeostasis	NOUN
ijpds-2950	120	10	in	in	ADP
ijpds-2950	120	11	the	the	DET
ijpds-2950	120	12	brain	brain	NOUN
ijpds-2950	120	13	.	.	PUNCT
ijpds-2950	121	1	protein	protein	NOUN
ijpds-2950	121	2	&	&	CCONJ
ijpds-2950	121	3	cell	cell	NOUN
ijpds-2950	121	4	.	.	PUNCT
ijpds-2950	122	1	2015:1	2015:1	NUM
ijpds-2950	122	2	;	;	PUNCT
ijpds-2950	122	3	6(4):254	6(4):254	NUM
ijpds-2950	122	4	-	-	SYM
ijpds-2950	122	5	64	64	NUM
ijpds-2950	122	6	.	.	PUNCT
ijpds-2950	123	1	7	7	X
ijpds-2950	123	2	.	.	X
ijpds-2950	123	3	dietschy	dietschy	ADJ
ijpds-2950	123	4	jm	jm	PROPN
ijpds-2950	123	5	and	and	CCONJ
ijpds-2950	123	6	turley	turley	PROPN
ijpds-2950	123	7	sd	sd	PROPN
ijpds-2950	123	8	.	.	PUNCT
ijpds-2950	124	1	thematic	thematic	ADJ
ijpds-2950	124	2	review	review	NOUN
ijpds-2950	124	3	series	series	NOUN
ijpds-2950	124	4	:	:	PUNCT
ijpds-2950	124	5	brain	brain	NOUN
ijpds-2950	124	6	lipids	lipids	PROPN
ijpds-2950	124	7	.	.	PUNCT
ijpds-2950	125	1	cholesterol	cholesterol	NOUN
ijpds-2950	125	2	metabolism	metabolism	NOUN
ijpds-2950	125	3	in	in	ADP
ijpds-2950	125	4	the	the	DET
ijpds-2950	125	5	central	central	ADJ
ijpds-2950	125	6	nervous	nervous	ADJ
ijpds-2950	125	7	system	system	NOUN
ijpds-2950	125	8	during	during	ADP
ijpds-2950	125	9	early	early	ADJ
ijpds-2950	125	10	development	development	NOUN
ijpds-2950	125	11	and	and	CCONJ
ijpds-2950	125	12	in	in	ADP
ijpds-2950	125	13	the	the	DET
ijpds-2950	125	14	mature	mature	ADJ
ijpds-2950	125	15	animal	animal	NOUN
ijpds-2950	125	16	.	.	PUNCT
ijpds-2950	126	1	j	j	PROPN
ijpds-2950	126	2	lipid	lipid	PROPN
ijpds-2950	126	3	res	re	NOUN
ijpds-2950	126	4	.	.	PUNCT
ijpds-2950	127	1	2004:1;45(8):1375	2004:1;45(8):1375	NUM
ijpds-2950	127	2	-	-	SYM
ijpds-2950	127	3	97	97	NUM
ijpds-2950	127	4	.	.	NOUN
ijpds-2950	128	1	8	8	NUM
ijpds-2950	128	2	.	.	PUNCT
ijpds-2950	129	1	orth	orth	PROPN
ijpds-2950	129	2	m	m	PROPN
ijpds-2950	129	3	,	,	PUNCT
ijpds-2950	129	4	bellosta	bellosta	PROPN
ijpds-2950	129	5	s.	s.	PROPN
ijpds-2950	129	6	cholesterol	cholesterol	PROPN
ijpds-2950	129	7	:	:	PUNCT
ijpds-2950	129	8	its	its	PRON
ijpds-2950	129	9	regulation	regulation	NOUN
ijpds-2950	129	10	and	and	CCONJ
ijpds-2950	129	11	role	role	NOUN
ijpds-2950	129	12	in	in	ADP
ijpds-2950	129	13	central	central	ADJ
ijpds-2950	129	14	nervous	nervous	ADJ
ijpds-2950	129	15	system	system	NOUN
ijpds-2950	129	16	disorders	disorder	NOUN
ijpds-2950	129	17	.	.	PUNCT
ijpds-2950	130	1	cholesterol	cholesterol	NOUN
ijpds-2950	130	2	.	.	PUNCT
ijpds-2950	131	1	2012	2012	NUM
ijpds-2950	131	2	.	.	PUNCT
ijpds-2950	132	1	sujeetha	sujeetha	PROPN
ijpds-2950	132	2	&	&	CCONJ
ijpds-2950	132	3	anand	anand	PROPN
ijpds-2950	132	4	cholesterol	cholesterol	PROPN
ijpds-2950	132	5	and	and	CCONJ
ijpds-2950	132	6	alzheimer	alzheimer	PROPN
ijpds-2950	132	7	’s	’s	PART
ijpds-2950	132	8	vol	vol	NOUN
ijpds-2950	132	9	1	1	NUM
ijpds-2950	132	10	|	|	ADV
ijpds-2950	132	11	issue	issue	VERB
ijpds-2950	132	12	1	1	NUM
ijpds-2950	132	13	|	|	ADV
ijpds-2950	132	14	apr	apr	ADV
ijpds-2950	132	15	–	–	PUNCT
ijpds-2950	132	16	jun	jun	PROPN
ijpds-2950	132	17	2022	2022	NUM
ijpds-2950	132	18	indian	indian	PROPN
ijpds-2950	132	19	j	j	PROPN
ijpds-2950	132	20	pharm	pharm	PROPN
ijpds-2950	132	21	drug	drug	PROPN
ijpds-2950	132	22	studies	study	NOUN
ijpds-2950	132	23	|	|	ADV
ijpds-2950	132	24	13	13	NUM
ijpds-2950	132	25	9	9	NUM
ijpds-2950	132	26	.	.	PUNCT
ijpds-2950	132	27	brown	brown	PROPN
ijpds-2950	132	28	aj	aj	PROPN
ijpds-2950	132	29	and	and	CCONJ
ijpds-2950	132	30	sharpe	sharpe	PROPN
ijpds-2950	132	31	lj	lj	PROPN
ijpds-2950	132	32	.	.	PUNCT
ijpds-2950	133	1	cholesterol	cholesterol	NOUN
ijpds-2950	133	2	synthesis	synthesis	NOUN
ijpds-2950	133	3	.	.	PUNCT
ijpds-2950	134	1	in	in	ADP
ijpds-2950	134	2	:	:	PUNCT
ijpds-2950	134	3	biochemistry	biochemistry	NOUN
ijpds-2950	134	4	of	of	ADP
ijpds-2950	134	5	lipids	lipid	NOUN
ijpds-2950	134	6	,	,	PUNCT
ijpds-2950	134	7	lipoproteins	lipoprotein	NOUN
ijpds-2950	134	8	and	and	CCONJ
ijpds-2950	134	9	membranes	membrane	NOUN
ijpds-2950	134	10	(	(	PUNCT
ijpds-2950	134	11	6th	6th	ADJ
ijpds-2950	134	12	ed).328	ed).328	NOUN
ijpds-2950	134	13	-	-	PUNCT
ijpds-2950	134	14	358	358	NUM
ijpds-2950	134	15	(	(	PUNCT
ijpds-2950	134	16	editors	editor	NOUN
ijpds-2950	134	17	nd	nd	ADP
ijpds-2950	134	18	ridgway	ridgway	NOUN
ijpds-2950	134	19	and	and	CCONJ
ijpds-2950	134	20	rs	rs	PROPN
ijpds-2950	134	21	mcleod	mcleod	PROPN
ijpds-2950	134	22	,	,	PUNCT
ijpds-2950	134	23	elsevier	elsevier	NOUN
ijpds-2950	134	24	,	,	PUNCT
ijpds-2950	134	25	amsterdam	amsterdam	PROPN
ijpds-2950	134	26	)	)	PUNCT
ijpds-2950	134	27	(	(	PUNCT
ijpds-2950	134	28	2016	2016	NUM
ijpds-2950	134	29	)	)	PUNCT
ijpds-2950	134	30	.	.	PUNCT
ijpds-2950	135	1	10	10	NUM
ijpds-2950	135	2	.	.	PUNCT
ijpds-2950	136	1	hussain	hussain	PROPN
ijpds-2950	136	2	g	g	PROPN
ijpds-2950	136	3	,	,	PUNCT
ijpds-2950	136	4	wang	wang	PROPN
ijpds-2950	136	5	j	j	PROPN
ijpds-2950	136	6	,	,	PUNCT
ijpds-2950	136	7	rasul	rasul	PROPN
ijpds-2950	136	8	a	a	PRON
ijpds-2950	136	9	et	et	PROPN
ijpds-2950	136	10	al	al	PROPN
ijpds-2950	136	11	.	.	PROPN
ijpds-2950	137	1	role	role	NOUN
ijpds-2950	137	2	of	of	ADP
ijpds-2950	137	3	cholesterol	cholesterol	NOUN
ijpds-2950	137	4	and	and	CCONJ
ijpds-2950	137	5	sphingolipids	sphingolipid	NOUN
ijpds-2950	137	6	in	in	ADP
ijpds-2950	137	7	brain	brain	NOUN
ijpds-2950	137	8	development	development	NOUN
ijpds-2950	137	9	and	and	CCONJ
ijpds-2950	137	10	neurological	neurological	ADJ
ijpds-2950	137	11	diseases	disease	NOUN
ijpds-2950	137	12	.	.	PUNCT
ijpds-2950	138	1	lipids	lipids	ADP
ijpds-2950	138	2	health	health	NOUN
ijpds-2950	138	3	dis	dis	PROPN
ijpds-2950	138	4	.	.	PUNCT
ijpds-2950	139	1	2019;18(1):1	2019;18(1):1	NUM
ijpds-2950	139	2	-	-	SYM
ijpds-2950	139	3	2	2	NUM
ijpds-2950	139	4	.	.	NOUN
ijpds-2950	139	5	11	11	NUM
ijpds-2950	139	6	.	.	PUNCT
ijpds-2950	140	1	simons	simon	NOUN
ijpds-2950	140	2	k	k	PROPN
ijpds-2950	140	3	,	,	PUNCT
ijpds-2950	140	4	ehehalt	ehehalt	PROPN
ijpds-2950	140	5	r.	r.	PROPN
ijpds-2950	140	6	cholesterol	cholesterol	PROPN
ijpds-2950	140	7	,	,	PUNCT
ijpds-2950	140	8	lipid	lipid	NOUN
ijpds-2950	140	9	rafts	raft	NOUN
ijpds-2950	140	10	,	,	PUNCT
ijpds-2950	140	11	and	and	CCONJ
ijpds-2950	140	12	disease	disease	NOUN
ijpds-2950	140	13	.	.	PUNCT
ijpds-2950	141	1	j	j	PROPN
ijpds-2950	141	2	clin	clin	PROPN
ijpds-2950	141	3	invest	invest	PROPN
ijpds-2950	141	4	.	.	PUNCT
ijpds-2950	142	1	2002:1;110(5):597	2002:1;110(5):597	NUM
ijpds-2950	142	2	-	-	SYM
ijpds-2950	142	3	603	603	NUM
ijpds-2950	142	4	.	.	PUNCT
ijpds-2950	143	1	12	12	NUM
ijpds-2950	143	2	.	.	PUNCT
ijpds-2950	144	1	rakesh	rakesh	PROPN
ijpds-2950	144	2	g	g	PROPN
ijpds-2950	144	3	,	,	PUNCT
ijpds-2950	144	4	szabo	szabo	PROPN
ijpds-2950	144	5	st	st	PROPN
ijpds-2950	144	6	,	,	PUNCT
ijpds-2950	144	7	alexopoulos	alexopoulos	PROPN
ijpds-2950	144	8	gs	gs	PROPN
ijpds-2950	144	9	et	et	PROPN
ijpds-2950	144	10	al	al	PROPN
ijpds-2950	144	11	.	.	PUNCT
ijpds-2950	144	12	strategies	strategy	NOUN
ijpds-2950	144	13	for	for	ADP
ijpds-2950	144	14	dementia	dementia	NOUN
ijpds-2950	144	15	prevention	prevention	NOUN
ijpds-2950	144	16	:	:	PUNCT
ijpds-2950	144	17	latest	late	ADJ
ijpds-2950	144	18	evidence	evidence	NOUN
ijpds-2950	144	19	and	and	CCONJ
ijpds-2950	144	20	implications	implication	NOUN
ijpds-2950	144	21	.	.	PUNCT
ijpds-2950	145	1	ther	ther	PROPN
ijpds-2950	145	2	advances	advance	VERB
ijpds-2950	145	3	chr	chr	PROPN
ijpds-2950	145	4	dis	dis	PROPN
ijpds-2950	145	5	.	.	PUNCT
ijpds-2950	146	1	2017;8(8	2017;8(8	NUM
ijpds-2950	146	2	-	-	PUNCT
ijpds-2950	146	3	9):121	9):121	NUM
ijpds-2950	146	4	-	-	PUNCT
ijpds-2950	146	5	36	36	NUM
ijpds-2950	146	6	.	.	NOUN
ijpds-2950	147	1	13	13	NUM
ijpds-2950	147	2	.	.	PUNCT
ijpds-2950	147	3	suzuki	suzuki	PROPN
ijpds-2950	147	4	t	t	PROPN
ijpds-2950	147	5	,	,	PUNCT
ijpds-2950	147	6	suzuki	suzuki	PROPN
ijpds-2950	147	7	y.	y.	PROPN
ijpds-2950	147	8	virus	virus	PROPN
ijpds-2950	147	9	infection	infection	NOUN
ijpds-2950	147	10	and	and	CCONJ
ijpds-2950	147	11	lipid	lipid	NOUN
ijpds-2950	147	12	rafts	raft	NOUN
ijpds-2950	147	13	.	.	PUNCT
ijpds-2950	148	1	biolog	biolog	PROPN
ijpds-2950	148	2	pharmaceut	pharmaceut	PROPN
ijpds-2950	148	3	bul	bul	PROPN
ijpds-2950	148	4	.	.	PUNCT
ijpds-2950	149	1	2006;29(8):1538	2006;29(8):1538	NUM
ijpds-2950	149	2	-	-	SYM
ijpds-2950	149	3	41	41	NUM
ijpds-2950	149	4	.	.	PUNCT
ijpds-2950	150	1	14	14	NUM
ijpds-2950	150	2	.	.	PUNCT
ijpds-2950	151	1	díaz	díaz	PROPN
ijpds-2950	151	2	m	m	PROPN
ijpds-2950	151	3	and	and	CCONJ
ijpds-2950	151	4	marin	marin	PROPN
ijpds-2950	151	5	r.	r.	PROPN
ijpds-2950	151	6	lipid	lipid	PROPN
ijpds-2950	151	7	rafts	raft	NOUN
ijpds-2950	151	8	and	and	CCONJ
ijpds-2950	151	9	development	development	NOUN
ijpds-2950	151	10	of	of	ADP
ijpds-2950	151	11	alzheimer	alzheimer	PROPN
ijpds-2950	151	12	’s	’s	PART
ijpds-2950	151	13	disease	disease	NOUN
ijpds-2950	151	14	.	.	PUNCT
ijpds-2950	152	1	cerebral	cerebral	ADJ
ijpds-2950	152	2	and	and	CCONJ
ijpds-2950	152	3	cerebellar	cerebellar	ADJ
ijpds-2950	152	4	cortex	cortex	NOUN
ijpds-2950	152	5	–	–	PUNCT
ijpds-2950	152	6	interaction	interaction	NOUN
ijpds-2950	152	7	and	and	CCONJ
ijpds-2950	152	8	dynamics	dynamic	NOUN
ijpds-2950	152	9	in	in	ADP
ijpds-2950	152	10	health	health	NOUN
ijpds-2950	152	11	and	and	CCONJ
ijpds-2950	152	12	disease	disease	NOUN
ijpds-2950	152	13	.	.	PUNCT
ijpds-2950	153	1	2021	2021	NUM
ijpds-2950	153	2	:	:	PUNCT
ijpds-2950	154	1	25	25	NUM
ijpds-2950	154	2	.	.	NOUN
ijpds-2950	154	3	15	15	NUM
ijpds-2950	154	4	.	.	PUNCT
ijpds-2950	155	1	vassar	vassar	PROPN
ijpds-2950	155	2	r	r	PROPN
ijpds-2950	155	3	,	,	PUNCT
ijpds-2950	155	4	kandalepas	kandalepas	NOUN
ijpds-2950	155	5	pc	pc	NOUN
ijpds-2950	155	6	.	.	PUNCT
ijpds-2950	156	1	the	the	DET
ijpds-2950	156	2	β	β	NOUN
ijpds-2950	156	3	-	-	ADJ
ijpds-2950	156	4	secretase	secretase	ADJ
ijpds-2950	156	5	enzyme	enzyme	NOUN
ijpds-2950	156	6	bace1	bace1	NOUN
ijpds-2950	156	7	as	as	ADP
ijpds-2950	156	8	a	a	DET
ijpds-2950	156	9	therapeutic	therapeutic	ADJ
ijpds-2950	156	10	target	target	NOUN
ijpds-2950	156	11	for	for	ADP
ijpds-2950	156	12	alzheimer	alzheimer	PROPN
ijpds-2950	156	13	's	's	PART
ijpds-2950	156	14	disease	disease	NOUN
ijpds-2950	156	15	.	.	PUNCT
ijpds-2950	157	1	alzheimer	alzheimer	PROPN
ijpds-2950	157	2	's	's	PART
ijpds-2950	157	3	res	re	NOUN
ijpds-2950	157	4	ther	ther	ADV
ijpds-2950	157	5	.	.	PUNCT
ijpds-2950	158	1	2011	2011	NUM
ijpds-2950	158	2	;	;	PUNCT
ijpds-2950	158	3	3(3):1	3(3):1	NUM
ijpds-2950	158	4	-	-	SYM
ijpds-2950	158	5	6	6	NUM
ijpds-2950	158	6	.	.	NOUN
ijpds-2950	158	7	16	16	NUM
ijpds-2950	158	8	.	.	PUNCT
ijpds-2950	159	1	shie	shie	PROPN
ijpds-2950	159	2	fs	fs	PROPN
ijpds-2950	159	3	,	,	PUNCT
ijpds-2950	159	4	jin	jin	PROPN
ijpds-2950	159	5	lw	lw	PROPN
ijpds-2950	159	6	,	,	PUNCT
ijpds-2950	159	7	cook	cook	VERB
ijpds-2950	159	8	dg	dg	PROPN
ijpds-2950	159	9	et	et	PROPN
ijpds-2950	159	10	al	al	PROPN
ijpds-2950	159	11	.	.	PROPN
ijpds-2950	159	12	,	,	PUNCT
ijpds-2950	159	13	diet	diet	NOUN
ijpds-2950	159	14	-	-	PUNCT
ijpds-2950	159	15	induced	induce	VERB
ijpds-2950	159	16	hypercholesterolemia	hypercholesterolemia	NOUN
ijpds-2950	159	17	enhances	enhance	NOUN
ijpds-2950	159	18	brain	brain	NOUN
ijpds-2950	159	19	aβ	aβ	ADP
ijpds-2950	159	20	accumulation	accumulation	NOUN
ijpds-2950	159	21	in	in	ADP
ijpds-2950	159	22	transgenic	transgenic	NOUN
ijpds-2950	159	23	mice	mouse	NOUN
ijpds-2950	159	24	.	.	PUNCT
ijpds-2950	160	1	neuroreport	neuroreport	NOUN
ijpds-2950	160	2	.	.	PUNCT
ijpds-2950	161	1	2002:25;13(4):455	2002:25;13(4):455	NUM
ijpds-2950	161	2	-	-	SYM
ijpds-2950	161	3	9	9	NUM
ijpds-2950	161	4	.	.	NOUN
ijpds-2950	161	5	17	17	NUM
ijpds-2950	161	6	.	.	PUNCT
ijpds-2950	162	1	refolo	refolo	PROPN
ijpds-2950	162	2	lm	lm	PROPN
ijpds-2950	162	3	,	,	PUNCT
ijpds-2950	162	4	pappolla	pappolla	PROPN
ijpds-2950	162	5	ma	ma	PROPN
ijpds-2950	162	6	,	,	PUNCT
ijpds-2950	162	7	malester	malester	PROPN
ijpds-2950	162	8	b	b	PROPN
ijpds-2950	162	9	et	et	PROPN
ijpds-2950	162	10	al	al	PROPN
ijpds-2950	162	11	.	.	PROPN
ijpds-2950	162	12	hypercholesterolemia	hypercholesterolemia	NOUN
ijpds-2950	162	13	accelerates	accelerate	VERB
ijpds-2950	162	14	the	the	DET
ijpds-2950	162	15	alzheimer	alzheimer	PROPN
ijpds-2950	162	16	's	's	PART
ijpds-2950	162	17	amyloid	amyloid	NOUN
ijpds-2950	162	18	pathology	pathology	NOUN
ijpds-2950	162	19	in	in	ADP
ijpds-2950	162	20	a	a	DET
ijpds-2950	162	21	transgenic	transgenic	NOUN
ijpds-2950	162	22	mouse	mouse	NOUN
ijpds-2950	162	23	model	model	NOUN
ijpds-2950	162	24	.	.	PUNCT
ijpds-2950	163	1	neurobiology	neurobiology	NOUN
ijpds-2950	163	2	of	of	ADP
ijpds-2950	163	3	disease	disease	NOUN
ijpds-2950	163	4	.	.	PUNCT
ijpds-2950	164	1	2000:1;7(4):321	2000:1;7(4):321	NUM
ijpds-2950	164	2	-	-	SYM
ijpds-2950	164	3	31	31	NUM
ijpds-2950	164	4	.	.	PUNCT
ijpds-2950	165	1	18	18	NUM
ijpds-2950	165	2	.	.	PUNCT
ijpds-2950	166	1	lim	lim	PROPN
ijpds-2950	166	2	wl	wl	PROPN
ijpds-2950	166	3	,	,	PUNCT
ijpds-2950	166	4	lam	lam	PROPN
ijpds-2950	166	5	sm	sm	PROPN
ijpds-2950	166	6	,	,	PUNCT
ijpds-2950	166	7	shui	shui	PROPN
ijpds-2950	166	8	g	g	PROPN
ijpds-2950	166	9	et	et	PROPN
ijpds-2950	166	10	al	al	PROPN
ijpds-2950	166	11	.	.	PUNCT
ijpds-2950	166	12	effects	effect	NOUN
ijpds-2950	166	13	of	of	ADP
ijpds-2950	166	14	a	a	DET
ijpds-2950	166	15	high	high	ADJ
ijpds-2950	166	16	fat	fat	NOUN
ijpds-2950	166	17	,	,	PUNCT
ijpds-2950	166	18	highcholesterol	highcholesterol	NOUN
ijpds-2950	166	19	diet	diet	NOUN
ijpds-2950	166	20	on	on	ADP
ijpds-2950	166	21	brain	brain	NOUN
ijpds-2950	166	22	lipid	lipid	NOUN
ijpds-2950	166	23	profiles	profile	NOUN
ijpds-2950	166	24	in	in	ADP
ijpds-2950	166	25	apolipoprotein	apolipoprotein	ADJ
ijpds-2950	166	26	e	e	NOUN
ijpds-2950	166	27	ɛ3	ɛ3	NOUN
ijpds-2950	166	28	and	and	CCONJ
ijpds-2950	166	29	ɛ4	ɛ4	VERB
ijpds-2950	166	30	knock	knock	NOUN
ijpds-2950	166	31	-	-	PUNCT
ijpds-2950	166	32	in	in	ADP
ijpds-2950	166	33	mice	mouse	NOUN
ijpds-2950	166	34	.	.	PUNCT
ijpds-2950	167	1	neuro	neuro	PROPN
ijpds-2950	167	2	.	.	PUNCT
ijpds-2950	168	1	of	of	ADP
ijpds-2950	168	2	aging	age	VERB
ijpds-2950	168	3	.	.	PUNCT
ijpds-2950	169	1	2013:1;34(9):2217	2013:1;34(9):2217	NUM
ijpds-2950	169	2	-	-	SYM
ijpds-2950	169	3	24	24	NUM
ijpds-2950	169	4	.	.	PUNCT
ijpds-2950	169	5	19	19	NUM
ijpds-2950	169	6	.	.	PUNCT
ijpds-2950	170	1	sepulveda	sepulveda	PROPN
ijpds-2950	170	2	-	-	PUNCT
ijpds-2950	170	3	diaz	diaz	PROPN
ijpds-2950	170	4	je	je	PROPN
ijpds-2950	170	5	,	,	PUNCT
ijpds-2950	170	6	alavi	alavi	PROPN
ijpds-2950	170	7	naini	naini	PROPN
ijpds-2950	170	8	sm	sm	PROPN
ijpds-2950	170	9	,	,	PUNCT
ijpds-2950	170	10	huynh	huynh	PROPN
ijpds-2950	170	11	mb	mb	PROPN
ijpds-2950	170	12	et	et	PROPN
ijpds-2950	170	13	al	al	PROPN
ijpds-2950	170	14	.	.	PROPN
ijpds-2950	170	15	and	and	CCONJ
ijpds-2950	170	16	hs3st2	hs3st2	NOUN
ijpds-2950	170	17	expression	expression	NOUN
ijpds-2950	170	18	is	be	AUX
ijpds-2950	170	19	critical	critical	ADJ
ijpds-2950	170	20	for	for	ADP
ijpds-2950	170	21	the	the	DET
ijpds-2950	170	22	abnormal	abnormal	ADJ
ijpds-2950	170	23	phosphorylation	phosphorylation	NOUN
ijpds-2950	170	24	of	of	ADP
ijpds-2950	170	25	tau	tau	PROPN
ijpds-2950	170	26	in	in	ADP
ijpds-2950	170	27	alzheimer	alzheimer	PROPN
ijpds-2950	170	28	’s	’s	PART
ijpds-2950	170	29	disease	disease	NOUN
ijpds-2950	170	30	-	-	PUNCT
ijpds-2950	170	31	related	relate	VERB
ijpds-2950	170	32	tau	tau	PROPN
ijpds-2950	170	33	pathology	pathology	NOUN
ijpds-2950	170	34	.	.	PUNCT
ijpds-2950	171	1	brain	brain	NOUN
ijpds-2950	171	2	.	.	PUNCT
ijpds-2950	172	1	2015:1;138(5):1339	2015:1;138(5):1339	NUM
ijpds-2950	172	2	-	-	SYM
ijpds-2950	172	3	54	54	NUM
ijpds-2950	172	4	.	.	NUM
ijpds-2950	173	1	20	20	NUM
ijpds-2950	173	2	.	.	X
ijpds-2950	173	3	fabelo	fabelo	PROPN
ijpds-2950	173	4	n	n	CCONJ
ijpds-2950	173	5	,	,	PUNCT
ijpds-2950	173	6	martín	martín	NOUN
ijpds-2950	173	7	v	v	NOUN
ijpds-2950	173	8	,	,	PUNCT
ijpds-2950	173	9	marín	marín	PROPN
ijpds-2950	173	10	r	r	NOUN
ijpds-2950	173	11	et	et	PROPN
ijpds-2950	173	12	al	al	PROPN
ijpds-2950	173	13	.	.	PROPN
ijpds-2950	174	1	altered	alter	VERB
ijpds-2950	174	2	lipid	lipid	NOUN
ijpds-2950	174	3	composition	composition	NOUN
ijpds-2950	174	4	in	in	ADP
ijpds-2950	174	5	cortical	cortical	ADJ
ijpds-2950	174	6	lipid	lipid	NOUN
ijpds-2950	174	7	rafts	raft	NOUN
ijpds-2950	174	8	occurs	occur	VERB
ijpds-2950	174	9	at	at	ADP
ijpds-2950	174	10	early	early	ADJ
ijpds-2950	174	11	stages	stage	NOUN
ijpds-2950	174	12	of	of	ADP
ijpds-2950	174	13	sporadic	sporadic	ADJ
ijpds-2950	174	14	alzheimer	alzheimer	PROPN
ijpds-2950	174	15	's	's	PART
ijpds-2950	174	16	disease	disease	NOUN
ijpds-2950	174	17	and	and	CCONJ
ijpds-2950	174	18	facilitates	facilitate	VERB
ijpds-2950	174	19	app	app	PROPN
ijpds-2950	174	20	/	/	SYM
ijpds-2950	174	21	bace1	bace1	NOUN
ijpds-2950	174	22	interactions	interaction	NOUN
ijpds-2950	174	23	.	.	PUNCT
ijpds-2950	175	1	neurobiology	neurobiology	NOUN
ijpds-2950	175	2	of	of	ADP
ijpds-2950	175	3	aging	aging	NOUN
ijpds-2950	175	4	.	.	PUNCT
ijpds-2950	176	1	2014:1;35(8):1801	2014:1;35(8):1801	NUM
ijpds-2950	176	2	-	-	SYM
ijpds-2950	176	3	12	12	NUM
ijpds-2950	176	4	.	.	PUNCT
ijpds-2950	177	1	21	21	NUM
ijpds-2950	177	2	.	.	PUNCT
ijpds-2950	178	1	igarashi	igarashi	PROPN
ijpds-2950	178	2	m	m	PROPN
ijpds-2950	178	3	,	,	PUNCT
ijpds-2950	178	4	ma	ma	PROPN
ijpds-2950	178	5	k	k	PROPN
ijpds-2950	178	6	,	,	PUNCT
ijpds-2950	178	7	et	et	PROPN
ijpds-2950	178	8	al	al	PROPN
ijpds-2950	178	9	.	.	PROPN
ijpds-2950	178	10	disturbed	disturbed	ADJ
ijpds-2950	178	11	choline	choline	NOUN
ijpds-2950	178	12	plasmalogen	plasmalogen	NOUN
ijpds-2950	178	13	and	and	CCONJ
ijpds-2950	178	14	phospholipid	phospholipid	NOUN
ijpds-2950	178	15	fatty	fatty	NOUN
ijpds-2950	178	16	acid	acid	NOUN
ijpds-2950	178	17	concentrations	concentration	NOUN
ijpds-2950	178	18	in	in	ADP
ijpds-2950	178	19	alzheimer	alzheimer	PROPN
ijpds-2950	178	20	's	's	PART
ijpds-2950	178	21	disease	disease	NOUN
ijpds-2950	178	22	prefrontal	prefrontal	ADJ
ijpds-2950	178	23	cortex	cortex	NOUN
ijpds-2950	178	24	.	.	PUNCT
ijpds-2950	179	1	j	j	PROPN
ijpds-2950	179	2	of	of	ADP
ijpds-2950	179	3	alzheimer	alzheimer	PROPN
ijpds-2950	179	4	's	's	PART
ijpds-2950	179	5	dise	dise	NOUN
ijpds-2950	179	6	.	.	PUNCT
ijpds-2950	180	1	2011:1;24(3):507	2011:1;24(3):507	NUM
ijpds-2950	180	2	-	-	SYM
ijpds-2950	180	3	17	17	NUM
ijpds-2950	180	4	.	.	PUNCT
ijpds-2950	181	1	22	22	NUM
ijpds-2950	181	2	.	.	PUNCT
ijpds-2950	182	1	santos	santos	PROPN
ijpds-2950	182	2	-	-	PUNCT
ijpds-2950	182	3	lozano	lozano	PROPN
ijpds-2950	182	4	a	a	PROPN
ijpds-2950	182	5	,	,	PUNCT
ijpds-2950	182	6	pareja	pareja	PROPN
ijpds-2950	182	7	-	-	PUNCT
ijpds-2950	182	8	galeano	galeano	PROPN
ijpds-2950	182	9	h	h	NOUN
ijpds-2950	182	10	,	,	PUNCT
ijpds-2950	182	11	sanchisgomar	sanchisgomar	PROPN
ijpds-2950	182	12	f	f	PROPN
ijpds-2950	182	13	et	et	PROPN
ijpds-2950	182	14	al	al	PROPN
ijpds-2950	182	15	.	.	PROPN
ijpds-2950	182	16	physical	physical	ADJ
ijpds-2950	182	17	activity	activity	NOUN
ijpds-2950	182	18	and	and	CCONJ
ijpds-2950	182	19	alzheimer	alzheimer	NOUN
ijpds-2950	182	20	disease	disease	PROPN
ijpds-2950	182	21	:	:	PUNCT
ijpds-2950	182	22	a	a	DET
ijpds-2950	182	23	protective	protective	ADJ
ijpds-2950	182	24	association	association	NOUN
ijpds-2950	182	25	.	.	PUNCT
ijpds-2950	183	1	inmayo	inmayo	VERB
ijpds-2950	183	2	clin	clin	PROPN
ijpds-2950	183	3	.	.	PUNCT
ijpds-2950	184	1	proceedings	proceeding	NOUN
ijpds-2950	184	2	2016:1;91:8;999	2016:1;91:8;999	NUM
ijpds-2950	184	3	-	-	SYM
ijpds-2950	184	4	1020	1020	NUM
ijpds-2950	184	5	.	.	PUNCT
ijpds-2950	185	1	23	23	NUM
ijpds-2950	185	2	.	.	PUNCT
ijpds-2950	186	1	van	van	PROPN
ijpds-2950	186	2	cauwenberghe	cauwenberghe	PROPN
ijpds-2950	186	3	c	c	PROPN
ijpds-2950	186	4	,	,	PUNCT
ijpds-2950	186	5	van	van	PROPN
ijpds-2950	186	6	broeckhoven	broeckhoven	NOUN
ijpds-2950	186	7	c	c	PROPN
ijpds-2950	186	8	,	,	PUNCT
ijpds-2950	186	9	sleegers	sleeger	NOUN
ijpds-2950	186	10	k.	k.	PROPN
ijpds-2950	186	11	the	the	DET
ijpds-2950	186	12	genetic	genetic	ADJ
ijpds-2950	186	13	landscape	landscape	NOUN
ijpds-2950	186	14	of	of	ADP
ijpds-2950	186	15	alzheimer	alzheimer	PROPN
ijpds-2950	186	16	disease	disease	PROPN
ijpds-2950	186	17	:	:	PUNCT
ijpds-2950	186	18	clinical	clinical	ADJ
ijpds-2950	186	19	implications	implication	NOUN
ijpds-2950	186	20	and	and	CCONJ
ijpds-2950	186	21	perspectives	perspective	NOUN
ijpds-2950	186	22	.	.	PUNCT
ijpds-2950	187	1	genetics	genetic	NOUN
ijpds-2950	187	2	in	in	ADP
ijpds-2950	187	3	medicine	medicine	NOUN
ijpds-2950	187	4	.	.	PUNCT
ijpds-2950	188	1	2016;18(5):421	2016;18(5):421	PROPN
ijpds-2950	188	2	-	-	PUNCT
ijpds-2950	188	3	30	30	NUM
ijpds-2950	188	4	.	.	PUNCT
ijpds-2950	189	1	24	24	NUM
ijpds-2950	189	2	.	.	X
ijpds-2950	189	3	serrano	serrano	PROPN
ijpds-2950	189	4	-	-	PUNCT
ijpds-2950	189	5	pozo	pozo	PROPN
ijpds-2950	189	6	a	a	PROPN
ijpds-2950	189	7	,	,	PUNCT
ijpds-2950	189	8	frosch	frosch	PROPN
ijpds-2950	189	9	mp	mp	PROPN
ijpds-2950	189	10	,	,	PUNCT
ijpds-2950	189	11	masliah	masliah	PROPN
ijpds-2950	189	12	e	e	PROPN
ijpds-2950	189	13	et	et	PROPN
ijpds-2950	189	14	al	al	PROPN
ijpds-2950	189	15	.	.	PUNCT
ijpds-2950	190	1	neuropathological	neuropathological	ADJ
ijpds-2950	190	2	alterations	alteration	NOUN
ijpds-2950	190	3	in	in	ADP
ijpds-2950	190	4	alzheimer	alzheimer	PROPN
ijpds-2950	190	5	disease	disease	PROPN
ijpds-2950	190	6	.	.	PUNCT
ijpds-2950	191	1	cold	cold	ADJ
ijpds-2950	191	2	spring	spring	NOUN
ijpds-2950	191	3	harbor	harbor	NOUN
ijpds-2950	191	4	perspectives	perspective	NOUN
ijpds-2950	191	5	in	in	ADP
ijpds-2950	191	6	medi	medi	PROPN
ijpds-2950	191	7	.	.	PUNCT
ijpds-2950	192	1	2011:1	2011:1	NUM
ijpds-2950	192	2	;	;	PUNCT
ijpds-2950	193	1	1(1):a006189	1(1):a006189	NUM
ijpds-2950	193	2	.	.	NOUN
ijpds-2950	193	3	25	25	NUM
ijpds-2950	193	4	.	.	X
ijpds-2950	194	1	rao	rao	NOUN
ijpds-2950	194	2	at	at	ADP
ijpds-2950	194	3	,	,	PUNCT
ijpds-2950	194	4	degnan	degnan	PROPN
ijpds-2950	194	5	aj	aj	PROPN
ijpds-2950	194	6	,	,	PUNCT
ijpds-2950	194	7	levy	levy	NOUN
ijpds-2950	194	8	lm	lm	PROPN
ijpds-2950	194	9	.	.	PUNCT
ijpds-2950	195	1	genetics	genetic	NOUN
ijpds-2950	195	2	of	of	ADP
ijpds-2950	195	3	alzheimer	alzheimer	PROPN
ijpds-2950	195	4	disease	disease	PROPN
ijpds-2950	195	5	.	.	PUNCT
ijpds-2950	196	1	american	american	PROPN
ijpds-2950	196	2	j	j	PROPN
ijpds-2950	196	3	of	of	ADP
ijpds-2950	196	4	neuroradiology	neuroradiology	NOUN
ijpds-2950	196	5	.	.	PUNCT
ijpds-2950	197	1	2014:1;35(3):457	2014:1;35(3):457	X
ijpds-2950	197	2	-	-	SYM
ijpds-2950	197	3	8	8	NUM
ijpds-2950	197	4	.	.	NOUN
ijpds-2950	197	5	26	26	NUM
ijpds-2950	197	6	.	.	PUNCT
ijpds-2950	197	7	sorrentino	sorrentino	PROPN
ijpds-2950	197	8	g	g	PROPN
ijpds-2950	197	9	,	,	PUNCT
ijpds-2950	197	10	bonavita	bonavita	PROPN
ijpds-2950	197	11	v.	v.	CCONJ
ijpds-2950	197	12	neurodegeneration	neurodegeneration	NOUN
ijpds-2950	197	13	and	and	CCONJ
ijpds-2950	197	14	alzheimer	alzheimer	PROPN
ijpds-2950	197	15	’s	’s	PART
ijpds-2950	197	16	disease	disease	NOUN
ijpds-2950	197	17	:	:	PUNCT
ijpds-2950	197	18	the	the	DET
ijpds-2950	197	19	lesson	lesson	NOUN
ijpds-2950	197	20	from	from	ADP
ijpds-2950	197	21	tauopathies	tauopathie	NOUN
ijpds-2950	197	22	.	.	PUNCT
ijpds-2950	198	1	neurological	neurological	ADJ
ijpds-2950	198	2	sciences	science	NOUN
ijpds-2950	198	3	.	.	PUNCT
ijpds-2950	199	1	2007;28(2):63	2007;28(2):63	X
ijpds-2950	199	2	-	-	SYM
ijpds-2950	199	3	71	71	NUM
ijpds-2950	199	4	.	.	PUNCT
ijpds-2950	200	1	27	27	NUM
ijpds-2950	200	2	.	.	PUNCT
ijpds-2950	201	1	razay	razay	ADV
ijpds-2950	201	2	g	g	PROPN
ijpds-2950	201	3	,	,	PUNCT
ijpds-2950	201	4	vreugdenhil	vreugdenhil	VERB
ijpds-2950	201	5	a	a	PRON
ijpds-2950	201	6	,	,	PUNCT
ijpds-2950	201	7	wilcock	wilcock	PROPN
ijpds-2950	201	8	g.	g.	PROPN
ijpds-2950	201	9	the	the	DET
ijpds-2950	201	10	metabolic	metabolic	NOUN
ijpds-2950	201	11	syndrome	syndrome	PROPN
ijpds-2950	201	12	and	and	CCONJ
ijpds-2950	201	13	alzheimer	alzheimer	PROPN
ijpds-2950	201	14	disease	disease	NOUN
ijpds-2950	201	15	.	.	PUNCT
ijpds-2950	202	1	archives	archive	NOUN
ijpds-2950	202	2	of	of	ADP
ijpds-2950	202	3	neuro	neuro	NOUN
ijpds-2950	202	4	.	.	PUNCT
ijpds-2950	203	1	2007:1;64(1):93	2007:1;64(1):93	NUM
ijpds-2950	203	2	-	-	SYM
ijpds-2950	203	3	6	6	NUM
ijpds-2950	203	4	.	.	NOUN
ijpds-2950	203	5	28	28	NUM
ijpds-2950	203	6	.	.	PUNCT
ijpds-2950	204	1	solfrizzi	solfrizzi	PROPN
ijpds-2950	204	2	v	v	PROPN
ijpds-2950	204	3	,	,	PUNCT
ijpds-2950	204	4	panza	panza	PROPN
ijpds-2950	204	5	f	f	PROPN
ijpds-2950	204	6	,	,	PUNCT
ijpds-2950	204	7	frisardi	frisardi	PROPN
ijpds-2950	204	8	v	v	INTJ
ijpds-2950	204	9	et	et	NOUN
ijpds-2950	204	10	al	al	PROPN
ijpds-2950	204	11	.	.	PROPN
ijpds-2950	204	12	diet	diet	PROPN
ijpds-2950	204	13	and	and	CCONJ
ijpds-2950	204	14	alzheimer	alzheimer	PROPN
ijpds-2950	204	15	’s	’s	PART
ijpds-2950	204	16	disease	disease	NOUN
ijpds-2950	204	17	risk	risk	NOUN
ijpds-2950	204	18	factors	factor	NOUN
ijpds-2950	204	19	or	or	CCONJ
ijpds-2950	204	20	prevention	prevention	NOUN
ijpds-2950	204	21	:	:	PUNCT
ijpds-2950	204	22	the	the	DET
ijpds-2950	204	23	current	current	ADJ
ijpds-2950	204	24	evidence	evidence	NOUN
ijpds-2950	204	25	.	.	PUNCT
ijpds-2950	205	1	expert	expert	NOUN
ijpds-2950	205	2	review	review	PROPN
ijpds-2950	205	3	of	of	ADP
ijpds-2950	205	4	neurotherapeutics	neurotherapeutic	NOUN
ijpds-2950	205	5	.	.	PUNCT
ijpds-2950	206	1	2011:1;11(5):677	2011:1;11(5):677	X
ijpds-2950	206	2	-	-	SYM
ijpds-2950	206	3	708	708	NUM
ijpds-2950	206	4	.	.	NOUN
ijpds-2950	207	1	29	29	NUM
ijpds-2950	207	2	.	.	PUNCT
ijpds-2950	208	1	dye	dye	NOUN
ijpds-2950	208	2	l	l	PROPN
ijpds-2950	208	3	,	,	PUNCT
ijpds-2950	208	4	boyle	boyle	PROPN
ijpds-2950	208	5	nb	nb	PROPN
ijpds-2950	208	6	,	,	PUNCT
ijpds-2950	208	7	champ	champ	PROPN
ijpds-2950	208	8	c	c	PROPN
ijpds-2950	208	9	,	,	PUNCT
ijpds-2950	208	10	et	et	PROPN
ijpds-2950	208	11	al	al	PROPN
ijpds-2950	208	12	.	.	PUNCT
ijpds-2950	209	1	the	the	DET
ijpds-2950	209	2	relationship	relationship	NOUN
ijpds-2950	209	3	between	between	ADP
ijpds-2950	209	4	obesity	obesity	NOUN
ijpds-2950	209	5	and	and	CCONJ
ijpds-2950	209	6	cognitive	cognitive	ADJ
ijpds-2950	209	7	health	health	NOUN
ijpds-2950	209	8	and	and	CCONJ
ijpds-2950	209	9	decline	decline	NOUN
ijpds-2950	209	10	.	.	PUNCT
ijpds-2950	210	1	proceedings	proceeding	NOUN
ijpds-2950	210	2	of	of	ADP
ijpds-2950	210	3	the	the	DET
ijpds-2950	210	4	nutrition	nutrition	NOUN
ijpds-2950	210	5	society	society	NOUN
ijpds-2950	210	6	.	.	PUNCT
ijpds-2950	211	1	2017;76(4):443	2017;76(4):443	NUM
ijpds-2950	211	2	-	-	SYM
ijpds-2950	211	3	54	54	NUM
ijpds-2950	211	4	.	.	PUNCT
ijpds-2950	211	5	30	30	NUM
ijpds-2950	211	6	.	.	X
ijpds-2950	212	1	cutler	cutler	PROPN
ijpds-2950	212	2	rg	rg	PROPN
ijpds-2950	212	3	,	,	PUNCT
ijpds-2950	212	4	kelly	kelly	PROPN
ijpds-2950	212	5	j	j	PROPN
ijpds-2950	212	6	,	,	PUNCT
ijpds-2950	212	7	storie	storie	PROPN
ijpds-2950	212	8	k	k	PROPN
ijpds-2950	212	9	,	,	PUNCT
ijpds-2950	212	10	et	et	PROPN
ijpds-2950	212	11	al	al	PROPN
ijpds-2950	212	12	.	.	PUNCT
ijpds-2950	212	13	involvement	involvement	NOUN
ijpds-2950	212	14	of	of	ADP
ijpds-2950	212	15	oxidative	oxidative	ADJ
ijpds-2950	212	16	stressinduced	stressinduce	VERB
ijpds-2950	212	17	abnormalities	abnormality	NOUN
ijpds-2950	212	18	in	in	ADP
ijpds-2950	212	19	ceramide	ceramide	NOUN
ijpds-2950	212	20	and	and	CCONJ
ijpds-2950	212	21	cholesterol	cholesterol	NOUN
ijpds-2950	212	22	metabolism	metabolism	NOUN
ijpds-2950	212	23	in	in	ADP
ijpds-2950	212	24	brain	brain	NOUN
ijpds-2950	212	25	aging	aging	NOUN
ijpds-2950	212	26	and	and	CCONJ
ijpds-2950	212	27	alzheimer	alzheimer	NOUN
ijpds-2950	212	28	's	's	PART
ijpds-2950	212	29	disease	disease	NOUN
ijpds-2950	212	30	.	.	PUNCT
ijpds-2950	213	1	proceedings	proceeding	NOUN
ijpds-2950	213	2	of	of	ADP
ijpds-2950	213	3	the	the	DET
ijpds-2950	213	4	nati	nati	NOUN
ijpds-2950	213	5	.	.	PUNCT
ijpds-2950	214	1	acad	acad	PROPN
ijpds-2950	214	2	.	.	PROPN
ijpds-2950	214	3	of	of	ADP
ijpds-2950	214	4	sci	sci	PROPN
ijpds-2950	214	5	.	.	PROPN
ijpds-2950	214	6	2004:17;101(7):2070	2004:17;101(7):2070	PROPN
ijpds-2950	214	7	-	-	SYM
ijpds-2950	214	8	5	5	NUM
ijpds-2950	214	9	.	.	NOUN
ijpds-2950	214	10	31	31	NUM
ijpds-2950	214	11	.	.	PUNCT
ijpds-2950	215	1	grimm	grimm	PROPN
ijpds-2950	215	2	mo	mo	PROPN
ijpds-2950	215	3	,	,	PUNCT
ijpds-2950	215	4	grimm	grimm	PROPN
ijpds-2950	215	5	hs	hs	PROPN
ijpds-2950	215	6	,	,	PUNCT
ijpds-2950	215	7	pätzold	pätzold	PROPN
ijpds-2950	215	8	aj	aj	PROPN
ijpds-2950	215	9	,	,	PUNCT
ijpds-2950	215	10	et	et	PROPN
ijpds-2950	215	11	al	al	PROPN
ijpds-2950	215	12	.	.	PUNCT
ijpds-2950	216	1	regulation	regulation	NOUN
ijpds-2950	216	2	of	of	ADP
ijpds-2950	216	3	cholesterol	cholesterol	NOUN
ijpds-2950	216	4	and	and	CCONJ
ijpds-2950	216	5	sphingomyelin	sphingomyelin	NOUN
ijpds-2950	216	6	metabolism	metabolism	NOUN
ijpds-2950	216	7	by	by	ADP
ijpds-2950	216	8	amyloid	amyloid	NOUN
ijpds-2950	216	9	-	-	PUNCT
ijpds-2950	216	10	β	β	X
ijpds-2950	216	11	and	and	CCONJ
ijpds-2950	216	12	presenilin	presenilin	PROPN
ijpds-2950	216	13	.	.	PUNCT
ijpds-2950	217	1	nature	nature	PROPN
ijpds-2950	217	2	cell	cell	NOUN
ijpds-2950	217	3	biology	biology	NOUN
ijpds-2950	217	4	.	.	PUNCT
ijpds-2950	218	1	2005;7(11):1118	2005;7(11):1118	NUM
ijpds-2950	218	2	-	-	SYM
ijpds-2950	218	3	23	23	NUM
ijpds-2950	218	4	.	.	PUNCT
ijpds-2950	219	1	32	32	NUM
ijpds-2950	219	2	.	.	PUNCT
ijpds-2950	220	1	zhang	zhang	PROPN
ijpds-2950	220	2	q	q	X
ijpds-2950	220	3	,	,	PUNCT
ijpds-2950	220	4	powers	powers	PROPN
ijpds-2950	220	5	et	et	PROPN
ijpds-2950	220	6	,	,	PUNCT
ijpds-2950	220	7	nieva	nieva	PROPN
ijpds-2950	220	8	j	j	PROPN
ijpds-2950	220	9	,	,	PUNCT
ijpds-2950	220	10	et	et	PROPN
ijpds-2950	220	11	al	al	PROPN
ijpds-2950	220	12	.	.	PROPN
ijpds-2950	220	13	metaboliteinitiated	metaboliteinitiate	VERB
ijpds-2950	220	14	protein	protein	NOUN
ijpds-2950	220	15	misfolding	misfolde	VERB
ijpds-2950	220	16	may	may	AUX
ijpds-2950	220	17	trigger	trigger	VERB
ijpds-2950	220	18	alzheimer	alzheimer	PROPN
ijpds-2950	220	19	's	's	PART
ijpds-2950	220	20	disease	disease	NOUN
ijpds-2950	220	21	.	.	PUNCT
ijpds-2950	221	1	proceedings	proceeding	NOUN
ijpds-2950	221	2	of	of	ADP
ijpds-2950	221	3	the	the	DET
ijpds-2950	221	4	national	national	PROPN
ijpds-2950	221	5	academy	academy	PROPN
ijpds-2950	221	6	of	of	ADP
ijpds-2950	221	7	sciences	sciences	PROPN
ijpds-2950	221	8	.	.	PUNCT
ijpds-2950	222	1	2004:6;101(14):4752	2004:6;101(14):4752	NUM
ijpds-2950	222	2	-	-	SYM
ijpds-2950	222	3	7	7	NUM
ijpds-2950	222	4	.	.	NOUN
ijpds-2950	222	5	33	33	NUM
ijpds-2950	222	6	.	.	PUNCT
ijpds-2950	223	1	xu	xu	PROPN
ijpds-2950	224	1	pt	pt	PROPN
ijpds-2950	224	2	,	,	PUNCT
ijpds-2950	224	3	li	li	PROPN
ijpds-2950	224	4	yj	yj	PROPN
ijpds-2950	224	5	,	,	PUNCT
ijpds-2950	224	6	qin	qin	PROPN
ijpds-2950	224	7	xj	xj	PROPN
ijpds-2950	224	8	et	et	PROPN
ijpds-2950	224	9	al	al	PROPN
ijpds-2950	224	10	.	.	PROPN
ijpds-2950	224	11	differences	difference	NOUN
ijpds-2950	224	12	in	in	ADP
ijpds-2950	224	13	apolipoprotein	apolipoprotein	ADJ
ijpds-2950	224	14	e3/3	e3/3	NOUN
ijpds-2950	224	15	and	and	CCONJ
ijpds-2950	224	16	e4/4	e4/4	ADV
ijpds-2950	224	17	allele	allele	NOUN
ijpds-2950	224	18	-	-	PUNCT
ijpds-2950	224	19	specific	specific	ADJ
ijpds-2950	224	20	gene	gene	NOUN
ijpds-2950	224	21	expression	expression	NOUN
ijpds-2950	224	22	in	in	ADP
ijpds-2950	224	23	hippocampus	hippocampus	NOUN
ijpds-2950	224	24	in	in	ADP
ijpds-2950	224	25	alzheimer	alzheimer	PROPN
ijpds-2950	224	26	disease	disease	PROPN
ijpds-2950	224	27	.	.	PUNCT
ijpds-2950	225	1	neuro	neuro	PROPN
ijpds-2950	225	2	.	.	PUNCT
ijpds-2950	226	1	of	of	ADP
ijpds-2950	226	2	disease	disease	NOUN
ijpds-2950	226	3	.	.	PUNCT
ijpds-2950	227	1	2006:1;21(2):256	2006:1;21(2):256	X
ijpds-2950	227	2	-	-	SYM
ijpds-2950	227	3	75	75	NUM
ijpds-2950	227	4	.	.	PUNCT
ijpds-2950	228	1	34	34	NUM
ijpds-2950	228	2	.	.	PUNCT
ijpds-2950	228	3	williams	williams	PROPN
ijpds-2950	228	4	t	t	PROPN
ijpds-2950	228	5	,	,	PUNCT
ijpds-2950	228	6	borchelt	borchelt	PROPN
ijpds-2950	228	7	dr	dr	PROPN
ijpds-2950	228	8	,	,	PUNCT
ijpds-2950	228	9	chakrabarty	chakrabarty	PROPN
ijpds-2950	229	1	p.	p.	PROPN
ijpds-2950	229	2	therapeutic	therapeutic	ADJ
ijpds-2950	229	3	approaches	approach	NOUN
ijpds-2950	229	4	targeting	target	VERB
ijpds-2950	229	5	apolipoprotein	apolipoprotein	ADJ
ijpds-2950	229	6	e	e	PROPN
ijpds-2950	229	7	function	function	NOUN
ijpds-2950	229	8	in	in	ADP
ijpds-2950	229	9	alzheimer	alzheimer	PROPN
ijpds-2950	229	10	’s	’s	PART
ijpds-2950	229	11	disease	disease	NOUN
ijpds-2950	229	12	.	.	PUNCT
ijpds-2950	230	1	molecular	molecular	ADJ
ijpds-2950	230	2	neurode	neurode	NOUN
ijpds-2950	230	3	.	.	PUNCT
ijpds-2950	231	1	2020:1;15(1):8	2020:1;15(1):8	PROPN
ijpds-2950	231	2	.	.	PUNCT
ijpds-2950	232	1	35	35	NUM
ijpds-2950	232	2	.	.	PUNCT
ijpds-2950	233	1	linton	linton	PROPN
ijpds-2950	233	2	mf	mf	PROPN
ijpds-2950	233	3	,	,	PUNCT
ijpds-2950	233	4	yancey	yancey	PROPN
ijpds-2950	233	5	pg	pg	PROPN
ijpds-2950	233	6	,	,	PUNCT
ijpds-2950	233	7	davies	davy	NOUN
ijpds-2950	233	8	ss	ss	VERB
ijpds-2950	233	9	et	et	PROPN
ijpds-2950	233	10	al	al	PROPN
ijpds-2950	233	11	.	.	PUNCT
ijpds-2950	234	1	the	the	DET
ijpds-2950	234	2	role	role	NOUN
ijpds-2950	234	3	of	of	ADP
ijpds-2950	234	4	lipids	lipid	NOUN
ijpds-2950	234	5	and	and	CCONJ
ijpds-2950	234	6	lipoproteins	lipoprotein	NOUN
ijpds-2950	234	7	in	in	ADP
ijpds-2950	234	8	atherosclerosis	atherosclerosis	NOUN
ijpds-2950	234	9	.	.	PUNCT
ijpds-2950	235	1	end	end	NOUN
ijpds-2950	235	2	text	text	NOUN
ijpds-2950	236	1	[	[	X
ijpds-2950	236	2	internet	internet	NOUN
ijpds-2950	236	3	]	]	PUNCT
ijpds-2950	236	4	.	.	PUNCT
ijpds-2950	237	1	2019:3	2019:3	NUM
ijpds-2950	237	2	.	.	PUNCT
ijpds-2950	238	1	36	36	NUM
ijpds-2950	238	2	.	.	PUNCT
ijpds-2950	239	1	heeren	heeren	PROPN
ijpds-2950	239	2	j	j	PROPN
ijpds-2950	239	3	,	,	PUNCT
ijpds-2950	239	4	grewal	grewal	PROPN
ijpds-2950	239	5	t	t	PROPN
ijpds-2950	239	6	,	,	PUNCT
ijpds-2950	239	7	laatsch	laatsch	VERB
ijpds-2950	239	8	a	a	PRON
ijpds-2950	239	9	,	,	PUNCT
ijpds-2950	239	10	et	et	PROPN
ijpds-2950	239	11	al	al	PROPN
ijpds-2950	239	12	.	.	PUNCT
ijpds-2950	240	1	impaired	impair	VERB
ijpds-2950	240	2	recycling	recycling	NOUN
ijpds-2950	240	3	of	of	ADP
ijpds-2950	240	4	apolipoprotein	apolipoprotein	ADJ
ijpds-2950	240	5	e4	e4	PROPN
ijpds-2950	240	6	is	be	AUX
ijpds-2950	240	7	associated	associate	VERB
ijpds-2950	240	8	with	with	ADP
ijpds-2950	240	9	intracellular	intracellular	ADJ
ijpds-2950	240	10	cholesterol	cholesterol	NOUN
ijpds-2950	240	11	accumulation	accumulation	NOUN
ijpds-2950	240	12	.	.	PUNCT
ijpds-2950	241	1	j	j	PROPN
ijpds-2950	241	2	biological	biological	ADJ
ijpds-2950	241	3	chem	chem	NOUN
ijpds-2950	241	4	.	.	PUNCT
ijpds-2950	242	1	2004:31	2004:31	NUM
ijpds-2950	243	1	;	;	PUNCT
ijpds-2950	243	2	279(53):55483	279(53):55483	PROPN
ijpds-2950	243	3	-	-	SYM
ijpds-2950	243	4	92	92	NUM
ijpds-2950	243	5	.	.	PUNCT
ijpds-2950	244	1	37	37	NUM
ijpds-2950	244	2	.	.	PUNCT
ijpds-2950	245	1	mamotte	mamotte	PROPN
ijpds-2950	245	2	cd	cd	PROPN
ijpds-2950	245	3	,	,	PUNCT
ijpds-2950	245	4	sturm	sturm	PROPN
ijpds-2950	245	5	m	m	PROPN
ijpds-2950	245	6	,	,	PUNCT
ijpds-2950	245	7	foo	foo	PROPN
ijpds-2950	245	8	ji	ji	PROPN
ijpds-2950	245	9	,	,	PUNCT
ijpds-2950	245	10	et	et	PROPN
ijpds-2950	245	11	al	al	PROPN
ijpds-2950	245	12	.	.	PROPN
ijpds-2950	245	13	comparison	comparison	NOUN
ijpds-2950	245	14	of	of	ADP
ijpds-2950	245	15	the	the	DET
ijpds-2950	245	16	ldlreceptor	ldlreceptor	NOUN
ijpds-2950	245	17	binding	bind	VERB
ijpds-2950	245	18	of	of	ADP
ijpds-2950	245	19	vldl	vldl	NOUN
ijpds-2950	245	20	and	and	CCONJ
ijpds-2950	245	21	ldl	ldl	VERB
ijpds-2950	245	22	from	from	ADP
ijpds-2950	245	23	apoe4	apoe4	PROPN
ijpds-2950	245	24	and	and	CCONJ
ijpds-2950	245	25	apoe3	apoe3	PROPN
ijpds-2950	245	26	homozygotes	homozygote	NOUN
ijpds-2950	245	27	.	.	PUNCT
ijpds-2950	245	28	am	be	AUX
ijpds-2950	245	29	j	j	PROPN
ijpds-2950	245	30	physiol	physiol	PROPN
ijpds-2950	245	31	-	-	PUNCT
ijpds-2950	245	32	endocrinol	endocrinol	NOUN
ijpds-2950	245	33	metabol	metabol	NOUN
ijpds-2950	245	34	.	.	PUNCT
ijpds-2950	246	1	1999:1;276(3):e553	1999:1;276(3):e553	NUM
ijpds-2950	246	2	-	-	SYM
ijpds-2950	246	3	7	7	NUM
ijpds-2950	246	4	.	.	NOUN
ijpds-2950	246	5	38	38	NUM
ijpds-2950	246	6	.	.	PUNCT
ijpds-2950	247	1	malloy	malloy	PROPN
ijpds-2950	247	2	p	p	PROPN
ijpds-2950	247	3	,	,	PUNCT
ijpds-2950	247	4	tremont	tremont	PROPN
ijpds-2950	247	5	g	g	PROPN
ijpds-2950	247	6	,	,	PUNCT
ijpds-2950	247	7	grace	grace	PROPN
ijpds-2950	247	8	j	j	PROPN
ijpds-2950	247	9	,	,	PUNCT
ijpds-2950	247	10	et	et	PROPN
ijpds-2950	247	11	al	al	PROPN
ijpds-2950	247	12	.	.	PUNCT
ijpds-2950	248	1	the	the	DET
ijpds-2950	248	2	frontal	frontal	ADJ
ijpds-2950	248	3	systems	system	NOUN
ijpds-2950	248	4	behavior	behavior	NOUN
ijpds-2950	248	5	scale	scale	NOUN
ijpds-2950	248	6	discriminates	discriminate	VERB
ijpds-2950	248	7	frontotemporal	frontotemporal	ADJ
ijpds-2950	248	8	dementia	dementia	NOUN
ijpds-2950	248	9	from	from	ADP
ijpds-2950	248	10	alzheimer	alzheimer	PROPN
ijpds-2950	248	11	’s	’s	PART
ijpds-2950	248	12	disease	disease	NOUN
ijpds-2950	248	13	.	.	PUNCT
ijpds-2950	249	1	alzheimer	alzheimer	PROPN
ijpds-2950	249	2	's	's	PART
ijpds-2950	249	3	&	&	CCONJ
ijpds-2950	249	4	deme	deme	PROPN
ijpds-2950	249	5	.	.	PUNCT
ijpds-2950	250	1	2007:1;3(3):200	2007:1;3(3):200	NOUN
ijpds-2950	250	2	-	-	PUNCT
ijpds-2950	250	3	3	3	NUM
ijpds-2950	250	4	.	.	NOUN
ijpds-2950	250	5	39	39	NUM
ijpds-2950	250	6	.	.	PUNCT
ijpds-2950	251	1	linton	linton	PROPN
ijpds-2950	251	2	mf	mf	PROPN
ijpds-2950	251	3	,	,	PUNCT
ijpds-2950	251	4	gish	gish	NOUN
ijpds-2950	251	5	r	r	PROPN
ijpds-2950	251	6	,	,	PUNCT
ijpds-2950	251	7	hubl	hubl	PROPN
ijpds-2950	251	8	st	st	PROPN
ijpds-2950	251	9	,	,	PUNCT
ijpds-2950	251	10	et	et	PROPN
ijpds-2950	251	11	al	al	PROPN
ijpds-2950	251	12	.	.	PUNCT
ijpds-2950	252	1	phenotypes	phenotype	NOUN
ijpds-2950	252	2	of	of	ADP
ijpds-2950	252	3	apolipoprotein	apolipoprotein	ADJ
ijpds-2950	252	4	b	b	PROPN
ijpds-2950	252	5	and	and	CCONJ
ijpds-2950	252	6	apolipoprotein	apolipoprotein	ADJ
ijpds-2950	252	7	e	e	NOUN
ijpds-2950	252	8	after	after	ADP
ijpds-2950	252	9	liver	liver	NOUN
ijpds-2950	252	10	transplantation	transplantation	NOUN
ijpds-2950	252	11	.	.	PUNCT
ijpds-2950	253	1	j	j	PROPN
ijpds-2950	253	2	clin	clin	PROPN
ijpds-2950	253	3	invest	invest	PROPN
ijpds-2950	253	4	.	.	PUNCT
ijpds-2950	254	1	1991:1;88(1):270	1991:1;88(1):270	NUM
ijpds-2950	254	2	-	-	SYM
ijpds-2950	254	3	81	81	NUM
ijpds-2950	254	4	.	.	PUNCT
ijpds-2950	255	1	40	40	NUM
ijpds-2950	255	2	.	.	PUNCT
ijpds-2950	256	1	boyle	boyle	PROPN
ijpds-2950	256	2	pa	pa	PROPN
ijpds-2950	256	3	,	,	PUNCT
ijpds-2950	256	4	buchman	buchman	PROPN
ijpds-2950	256	5	as	as	ADP
ijpds-2950	256	6	,	,	PUNCT
ijpds-2950	256	7	wilson	wilson	PROPN
ijpds-2950	256	8	rs	rs	PROPN
ijpds-2950	256	9	,	,	PUNCT
ijpds-2950	256	10	et	et	PROPN
ijpds-2950	256	11	al	al	PROPN
ijpds-2950	256	12	.	.	PROPN
ijpds-2950	256	13	effect	effect	NOUN
ijpds-2950	256	14	of	of	ADP
ijpds-2950	256	15	purpose	purpose	NOUN
ijpds-2950	256	16	in	in	ADP
ijpds-2950	256	17	life	life	NOUN
ijpds-2950	256	18	on	on	ADP
ijpds-2950	256	19	the	the	DET
ijpds-2950	256	20	relation	relation	NOUN
ijpds-2950	256	21	between	between	ADP
ijpds-2950	256	22	alzheimer	alzheimer	PROPN
ijpds-2950	256	23	disease	disease	NOUN
ijpds-2950	256	24	pathologic	pathologic	ADJ
ijpds-2950	256	25	changes	change	NOUN
ijpds-2950	256	26	on	on	ADP
ijpds-2950	256	27	cognitive	cognitive	ADJ
ijpds-2950	256	28	function	function	NOUN
ijpds-2950	256	29	in	in	ADP
ijpds-2950	256	30	advanced	advanced	ADJ
ijpds-2950	256	31	age	age	NOUN
ijpds-2950	256	32	.	.	PUNCT
ijpds-2950	257	1	archives	archive	NOUN
ijpds-2950	257	2	of	of	ADP
ijpds-2950	257	3	general	general	ADJ
ijpds-2950	257	4	psychiatry	psychiatry	NOUN
ijpds-2950	257	5	.	.	PUNCT
ijpds-2950	258	1	2012:1	2012:1	NUM
ijpds-2950	258	2	;	;	PUNCT
ijpds-2950	258	3	69(5):pp499	69(5):pp499	NOUN
ijpds-2950	258	4	-	-	PUNCT
ijpds-2950	258	5	504	504	NUM
ijpds-2950	258	6	.	.	PUNCT
ijpds-2950	258	7	41	41	NUM
ijpds-2950	258	8	.	.	PUNCT
ijpds-2950	259	1	shinohara	shinohara	PROPN
ijpds-2950	259	2	m	m	PROPN
ijpds-2950	259	3	,	,	PUNCT
ijpds-2950	259	4	tachibana	tachibana	PROPN
ijpds-2950	259	5	m	m	PROPN
ijpds-2950	259	6	,	,	PUNCT
ijpds-2950	259	7	kanekiyo	kanekiyo	PROPN
ijpds-2950	259	8	t	t	PROPN
ijpds-2950	259	9	,	,	PUNCT
ijpds-2950	259	10	et	et	PROPN
ijpds-2950	259	11	al	al	PROPN
ijpds-2950	259	12	.	.	PROPN
ijpds-2950	259	13	role	role	NOUN
ijpds-2950	259	14	of	of	ADP
ijpds-2950	259	15	lrp1	lrp1	NOUN
ijpds-2950	259	16	in	in	ADP
ijpds-2950	259	17	the	the	DET
ijpds-2950	259	18	pathogenesis	pathogenesis	NOUN
ijpds-2950	259	19	of	of	ADP
ijpds-2950	259	20	alzheimer	alzheimer	PROPN
ijpds-2950	259	21	's	's	PART
ijpds-2950	259	22	disease	disease	NOUN
ijpds-2950	259	23	:	:	PUNCT
ijpds-2950	259	24	evidence	evidence	NOUN
ijpds-2950	259	25	from	from	ADP
ijpds-2950	259	26	clinical	clinical	ADJ
ijpds-2950	259	27	and	and	CCONJ
ijpds-2950	259	28	preclinical	preclinical	ADJ
ijpds-2950	259	29	studies	study	NOUN
ijpds-2950	259	30	:	:	PUNCT
ijpds-2950	259	31	thematic	thematic	ADJ
ijpds-2950	259	32	review	review	NOUN
ijpds-2950	259	33	series	series	NOUN
ijpds-2950	259	34	:	:	PUNCT
ijpds-2950	259	35	apoe	apoe	ADJ
ijpds-2950	259	36	and	and	CCONJ
ijpds-2950	259	37	lipid	lipid	ADJ
ijpds-2950	259	38	homeostasis	homeostasis	NOUN
ijpds-2950	259	39	in	in	ADP
ijpds-2950	259	40	alzheimer	alzheimer	PROPN
ijpds-2950	259	41	's	's	PART
ijpds-2950	259	42	disease	disease	NOUN
ijpds-2950	259	43	.	.	PUNCT
ijpds-2950	260	1	journal	journal	PROPN
ijpds-2950	260	2	of	of	ADP
ijpds-2950	260	3	lipid	lipid	PROPN
ijpds-2950	260	4	research	research	NOUN
ijpds-2950	260	5	.	.	PUNCT
ijpds-2950	261	1	2017:1	2017:1	NUM
ijpds-2950	261	2	;	;	PUNCT
ijpds-2950	262	1	58(7):1267	58(7):1267	NUM
ijpds-2950	262	2	-	-	SYM
ijpds-2950	262	3	81	81	NUM
ijpds-2950	262	4	.	.	PUNCT
ijpds-2950	263	1	42	42	NUM
ijpds-2950	263	2	.	.	PUNCT
ijpds-2950	264	1	lane	lane	NOUN
ijpds-2950	264	2	-	-	PUNCT
ijpds-2950	264	3	donovan	donovan	PROPN
ijpds-2950	264	4	c	c	PROPN
ijpds-2950	264	5	,	,	PUNCT
ijpds-2950	264	6	herz	herz	PROPN
ijpds-2950	264	7	j.	j.	PROPN
ijpds-2950	264	8	apoe	apoe	PROPN
ijpds-2950	264	9	,	,	PUNCT
ijpds-2950	264	10	apoe	apoe	ADJ
ijpds-2950	264	11	receptors	receptor	NOUN
ijpds-2950	264	12	,	,	PUNCT
ijpds-2950	264	13	and	and	CCONJ
ijpds-2950	264	14	the	the	DET
ijpds-2950	264	15	synapse	synapse	NOUN
ijpds-2950	264	16	in	in	ADP
ijpds-2950	264	17	alzheimer	alzheimer	PROPN
ijpds-2950	264	18	's	's	PART
ijpds-2950	264	19	disease	disease	NOUN
ijpds-2950	264	20	.	.	PUNCT
ijpds-2950	265	1	trends	trend	NOUN
ijpds-2950	265	2	endocrinol	endocrinol	VERB
ijpds-2950	265	3	metabol	metabol	NOUN
ijpds-2950	265	4	.	.	PUNCT
ijpds-2950	266	1	2017:1;28(4):273	2017:1;28(4):273	NUM
ijpds-2950	266	2	-	-	SYM
ijpds-2950	266	3	84	84	NUM
ijpds-2950	266	4	.	.	PUNCT
ijpds-2950	267	1	43	43	NUM
ijpds-2950	267	2	.	.	PUNCT
ijpds-2950	268	1	petrov	petrov	PROPN
ijpds-2950	268	2	am	am	PROPN
ijpds-2950	268	3	,	,	PUNCT
ijpds-2950	268	4	kasimov	kasimov	ADJ
ijpds-2950	268	5	mr	mr	PROPN
ijpds-2950	268	6	,	,	PUNCT
ijpds-2950	268	7	zefirov	zefirov	PROPN
ijpds-2950	268	8	al	al	PROPN
ijpds-2950	268	9	.	.	PROPN
ijpds-2950	268	10	brain	brain	PROPN
ijpds-2950	268	11	cholesterol	cholesterol	NOUN
ijpds-2950	268	12	metabolism	metabolism	NOUN
ijpds-2950	268	13	and	and	CCONJ
ijpds-2950	268	14	its	its	PRON
ijpds-2950	268	15	defects	defect	NOUN
ijpds-2950	268	16	:	:	PUNCT
ijpds-2950	268	17	linkage	linkage	NOUN
ijpds-2950	268	18	to	to	ADP
ijpds-2950	268	19	neurodegenerative	neurodegenerative	ADJ
ijpds-2950	268	20	diseases	disease	NOUN
ijpds-2950	268	21	and	and	CCONJ
ijpds-2950	268	22	synaptic	synaptic	ADJ
ijpds-2950	268	23	dysfunction	dysfunction	NOUN
ijpds-2950	268	24	.	.	PUNCT
ijpds-2950	269	1	acta	acta	PROPN
ijpds-2950	269	2	naturae	naturae	PROPN
ijpds-2950	269	3	2016;8(1):28	2016;8(1):28	NUM
ijpds-2950	269	4	.	.	PROPN
ijpds-2950	269	5	44	44	NUM
ijpds-2950	269	6	.	.	PUNCT
ijpds-2950	270	1	baker	baker	NOUN
ijpds-2950	270	2	-	-	PUNCT
ijpds-2950	270	3	nigh	nigh	PROPN
ijpds-2950	270	4	a	a	PRON
ijpds-2950	270	5	,	,	PUNCT
ijpds-2950	270	6	vahedi	vahedi	PROPN
ijpds-2950	270	7	s	s	PROPN
ijpds-2950	270	8	,	,	PUNCT
ijpds-2950	270	9	davis	davis	PROPN
ijpds-2950	270	10	eg	eg	PROPN
ijpds-2950	270	11	,	,	PUNCT
ijpds-2950	270	12	et	et	PROPN
ijpds-2950	270	13	al	al	PROPN
ijpds-2950	270	14	.	.	PUNCT
ijpds-2950	271	1	neuronal	neuronal	ADJ
ijpds-2950	271	2	amyloid	amyloid	NOUN
ijpds-2950	271	3	-	-	PUNCT
ijpds-2950	271	4	β	β	NOUN
ijpds-2950	271	5	accumulation	accumulation	NOUN
ijpds-2950	271	6	within	within	ADP
ijpds-2950	271	7	cholinergic	cholinergic	ADJ
ijpds-2950	271	8	basal	basal	NOUN
ijpds-2950	271	9	forebrain	forebrain	NOUN
ijpds-2950	271	10	in	in	ADP
ijpds-2950	271	11	ageing	ageing	NOUN
ijpds-2950	271	12	and	and	CCONJ
ijpds-2950	271	13	alzheimer	alzheimer	NOUN
ijpds-2950	271	14	’s	’s	PART
ijpds-2950	271	15	disease	disease	NOUN
ijpds-2950	271	16	.	.	PUNCT
ijpds-2950	272	1	brain	brain	NOUN
ijpds-2950	272	2	.	.	PUNCT
ijpds-2950	273	1	2015:1;138(6):1722	2015:1;138(6):1722	NUM
ijpds-2950	273	2	-	-	SYM
ijpds-2950	273	3	37	37	NUM
ijpds-2950	273	4	.	.	PUNCT
ijpds-2950	274	1	45	45	NUM
ijpds-2950	274	2	.	.	PUNCT
ijpds-2950	275	1	maezawa	maezawa	PROPN
ijpds-2950	275	2	i	i	PRON
ijpds-2950	275	3	,	,	PUNCT
ijpds-2950	275	4	hong	hong	PROPN
ijpds-2950	275	5	hs	hs	PROPN
ijpds-2950	275	6	,	,	PUNCT
ijpds-2950	275	7	wu	wu	PROPN
ijpds-2950	275	8	hc	hc	PROPN
ijpds-2950	275	9	,	,	PUNCT
ijpds-2950	275	10	et	et	PROPN
ijpds-2950	275	11	al	al	PROPN
ijpds-2950	275	12	.	.	PUNCT
ijpds-2950	276	1	a	a	DET
ijpds-2950	276	2	novel	novel	ADJ
ijpds-2950	276	3	tricyclic	tricyclic	ADJ
ijpds-2950	276	4	pyrone	pyrone	NOUN
ijpds-2950	276	5	compound	compound	NOUN
ijpds-2950	276	6	ameliorates	ameliorate	VERB
ijpds-2950	276	7	cell	cell	NOUN
ijpds-2950	276	8	death	death	NOUN
ijpds-2950	276	9	associated	associate	VERB
ijpds-2950	276	10	with	with	ADP
ijpds-2950	276	11	intracellular	intracellular	ADJ
ijpds-2950	276	12	amyloid	amyloid	NOUN
ijpds-2950	276	13	aβ	aβ	ADP
ijpds-2950	276	14	oligomeric	oligomeric	ADJ
ijpds-2950	276	15	complexes	complex	NOUN
ijpds-2950	276	16	.	.	PUNCT
ijpds-2950	277	1	j	j	PROPN
ijpds-2950	277	2	neur	neur	PROPN
ijpds-2950	277	3	.	.	PUNCT
ijpds-2950	278	1	2006;98(1):57	2006;98(1):57	X
ijpds-2950	278	2	-	-	SYM
ijpds-2950	278	3	67	67	NUM
ijpds-2950	278	4	.	.	PUNCT
ijpds-2950	278	5	46	46	NUM
ijpds-2950	278	6	.	.	PUNCT
ijpds-2950	279	1	taddei	taddei	PROPN
ijpds-2950	279	2	s	s	PROPN
ijpds-2950	279	3	,	,	PUNCT
ijpds-2950	279	4	virdis	virdis	VERB
ijpds-2950	279	5	a	a	PRON
ijpds-2950	279	6	,	,	PUNCT
ijpds-2950	279	7	mattei	mattei	NOUN
ijpds-2950	279	8	p	p	NOUN
ijpds-2950	279	9	,	,	PUNCT
ijpds-2950	279	10	et	et	PROPN
ijpds-2950	279	11	al	al	PROPN
ijpds-2950	279	12	.	.	PUNCT
ijpds-2950	279	13	hypertension	hypertension	NOUN
ijpds-2950	279	14	causes	cause	VERB
ijpds-2950	279	15	premature	premature	ADJ
ijpds-2950	279	16	aging	aging	NOUN
ijpds-2950	279	17	of	of	ADP
ijpds-2950	279	18	endothelial	endothelial	ADJ
ijpds-2950	279	19	function	function	NOUN
ijpds-2950	279	20	in	in	ADP
ijpds-2950	279	21	humans	human	NOUN
ijpds-2950	279	22	.	.	PUNCT
ijpds-2950	280	1	hypertension	hypertension	NOUN
ijpds-2950	280	2	.	.	PUNCT
ijpds-2950	281	1	1997;29(3):736	1997;29(3):736	PROPN
ijpds-2950	281	2	-	-	SYM
ijpds-2950	281	3	43	43	NUM
ijpds-2950	281	4	.	.	PUNCT
ijpds-2950	282	1	47	47	NUM
ijpds-2950	282	2	.	.	PUNCT
ijpds-2950	283	1	laws	law	NOUN
ijpds-2950	283	2	sm	sm	PROPN
ijpds-2950	283	3	,	,	PUNCT
ijpds-2950	283	4	taddei	taddei	PROPN
ijpds-2950	283	5	k	k	PROPN
ijpds-2950	283	6	,	,	PUNCT
ijpds-2950	283	7	martins	martin	VERB
ijpds-2950	283	8	g	g	NOUN
ijpds-2950	283	9	,	,	PUNCT
ijpds-2950	283	10	et	et	PROPN
ijpds-2950	283	11	al	al	PROPN
ijpds-2950	283	12	.	.	PUNCT
ijpds-2950	284	1	the	the	DET
ijpds-2950	284	2	491aa	491aa	PROPN
ijpds-2950	284	3	polymorphism	polymorphism	NOUN
ijpds-2950	284	4	in	in	ADP
ijpds-2950	284	5	the	the	DET
ijpds-2950	284	6	apoe	apoe	ADJ
ijpds-2950	284	7	gene	gene	NOUN
ijpds-2950	284	8	is	be	AUX
ijpds-2950	284	9	associated	associate	VERB
ijpds-2950	284	10	with	with	ADP
ijpds-2950	284	11	increased	increase	VERB
ijpds-2950	284	12	plasma	plasma	NOUN
ijpds-2950	284	13	apoe	apoe	NOUN
ijpds-2950	284	14	levels	level	NOUN
ijpds-2950	284	15	in	in	ADP
ijpds-2950	284	16	alzheimer	alzheimer	PROPN
ijpds-2950	284	17	's	's	PART
ijpds-2950	284	18	disease	disease	NOUN
ijpds-2950	284	19	.	.	PUNCT
ijpds-2950	285	1	neuroreport	neuroreport	NOUN
ijpds-2950	285	2	.	.	PUNCT
ijpds-2950	286	1	1999:17;10(4):879	1999:17;10(4):879	NUM
ijpds-2950	286	2	-	-	SYM
ijpds-2950	286	3	82	82	NUM
ijpds-2950	286	4	.	.	PUNCT
ijpds-2950	287	1	48	48	NUM
ijpds-2950	287	2	.	.	PUNCT
ijpds-2950	288	1	laws	law	NOUN
ijpds-2950	288	2	kr	kr	PROPN
ijpds-2950	288	3	,	,	PUNCT
ijpds-2950	288	4	gale	gale	PROPN
ijpds-2950	288	5	tm	tm	PROPN
ijpds-2950	288	6	,	,	PUNCT
ijpds-2950	288	7	leeson	leeson	PROPN
ijpds-2950	288	8	vc	vc	PROPN
ijpds-2950	288	9	,	,	PUNCT
ijpds-2950	288	10	et	et	PROPN
ijpds-2950	288	11	al	al	PROPN
ijpds-2950	288	12	.	.	PROPN
ijpds-2950	289	1	when	when	SCONJ
ijpds-2950	289	2	is	be	AUX
ijpds-2950	289	3	category	category	NOUN
ijpds-2950	289	4	specific	specific	ADJ
ijpds-2950	289	5	in	in	ADP
ijpds-2950	289	6	alzheimer	alzheimer	PROPN
ijpds-2950	289	7	's	's	PART
ijpds-2950	289	8	disease	disease	NOUN
ijpds-2950	289	9	?	?	PUNCT
ijpds-2950	290	1	cortex	cortex	NOUN
ijpds-2950	290	2	.	.	PUNCT
ijpds-2950	291	1	2005:1	2005:1	NUM
ijpds-2950	291	2	;	;	PUNCT
ijpds-2950	291	3	41(4):452	41(4):452	NOUN
ijpds-2950	291	4	-	-	SYM
ijpds-2950	291	5	63	63	NUM
ijpds-2950	291	6	.	.	PUNCT
ijpds-2950	292	1	sujeetha	sujeetha	PROPN
ijpds-2950	292	2	&	&	CCONJ
ijpds-2950	292	3	anand	anand	PROPN
ijpds-2950	292	4	cholesterol	cholesterol	PROPN
ijpds-2950	292	5	and	and	CCONJ
ijpds-2950	292	6	alzheimer	alzheimer	PROPN
ijpds-2950	292	7	’s	’s	PART
ijpds-2950	292	8	vol	vol	NOUN
ijpds-2950	292	9	1	1	NUM
ijpds-2950	292	10	|	|	ADV
ijpds-2950	292	11	issue	issue	VERB
ijpds-2950	292	12	1	1	NUM
ijpds-2950	292	13	|	|	ADV
ijpds-2950	292	14	apr	apr	ADV
ijpds-2950	292	15	–	–	PUNCT
ijpds-2950	292	16	jun	jun	PROPN
ijpds-2950	292	17	2022	2022	NUM
ijpds-2950	292	18	indian	indian	PROPN
ijpds-2950	292	19	j	j	PROPN
ijpds-2950	292	20	pharm	pharm	PROPN
ijpds-2950	292	21	drug	drug	PROPN
ijpds-2950	292	22	studies	study	NOUN
ijpds-2950	292	23	|	|	ADV
ijpds-2950	292	24	14	14	NUM
ijpds-2950	292	25	49	49	NUM
ijpds-2950	292	26	.	.	PUNCT
ijpds-2950	293	1	lambert	lambert	PROPN
ijpds-2950	293	2	mp	mp	PROPN
ijpds-2950	293	3	,	,	PUNCT
ijpds-2950	293	4	barlow	barlow	PROPN
ijpds-2950	293	5	ak	ak	PROPN
ijpds-2950	293	6	,	,	PUNCT
ijpds-2950	293	7	chromy	chromy	PROPN
ijpds-2950	293	8	ba	ba	PROPN
ijpds-2950	293	9	,	,	PUNCT
ijpds-2950	293	10	et	et	PROPN
ijpds-2950	293	11	al	al	PROPN
ijpds-2950	293	12	.	.	PROPN
ijpds-2950	294	1	diffusible	diffusible	ADJ
ijpds-2950	294	2	,	,	PUNCT
ijpds-2950	294	3	nonfibrillar	nonfibrillar	ADJ
ijpds-2950	294	4	ligands	ligand	NOUN
ijpds-2950	294	5	derived	derive	VERB
ijpds-2950	294	6	from	from	ADP
ijpds-2950	294	7	aβ1	aβ1	NOUN
ijpds-2950	294	8	–	–	PUNCT
ijpds-2950	294	9	42	42	NUM
ijpds-2950	294	10	are	be	AUX
ijpds-2950	294	11	potent	potent	ADJ
ijpds-2950	294	12	central	central	ADJ
ijpds-2950	294	13	nervous	nervous	ADJ
ijpds-2950	294	14	system	system	NOUN
ijpds-2950	294	15	neurotoxins	neurotoxin	NOUN
ijpds-2950	294	16	.	.	PUNCT
ijpds-2950	295	1	proceedings	proceeding	NOUN
ijpds-2950	295	2	of	of	ADP
ijpds-2950	295	3	the	the	DET
ijpds-2950	295	4	national	national	PROPN
ijpds-2950	295	5	academy	academy	PROPN
ijpds-2950	295	6	of	of	ADP
ijpds-2950	295	7	sciences	sciences	PROPN
ijpds-2950	295	8	.	.	PUNCT
ijpds-2950	296	1	1998:26;95(11):6448	1998:26;95(11):6448	X
ijpds-2950	296	2	-	-	SYM
ijpds-2950	296	3	53	53	NUM
ijpds-2950	296	4	.	.	NOUN
ijpds-2950	297	1	50	50	NUM
ijpds-2950	297	2	.	.	PUNCT
ijpds-2950	298	1	rasmussen	rasmussen	PROPN
ijpds-2950	298	2	kl	kl	PROPN
ijpds-2950	298	3	,	,	PUNCT
ijpds-2950	298	4	tybjærg	tybjærg	PROPN
ijpds-2950	298	5	-	-	PUNCT
ijpds-2950	298	6	hansen	hansen	PROPN
ijpds-2950	298	7	a	a	PROPN
ijpds-2950	298	8	,	,	PUNCT
ijpds-2950	298	9	nordestgaard	nordestgaard	PROPN
ijpds-2950	298	10	bg	bg	PROPN
ijpds-2950	298	11	,	,	PUNCT
ijpds-2950	298	12	et	et	PROPN
ijpds-2950	298	13	al	al	PROPN
ijpds-2950	298	14	.	.	PUNCT
ijpds-2950	299	1	absolute	absolute	ADJ
ijpds-2950	299	2	10	10	NUM
ijpds-2950	299	3	-	-	PUNCT
ijpds-2950	299	4	year	year	NOUN
ijpds-2950	299	5	risk	risk	NOUN
ijpds-2950	299	6	of	of	ADP
ijpds-2950	299	7	dementia	dementia	NOUN
ijpds-2950	299	8	by	by	ADP
ijpds-2950	299	9	age	age	NOUN
ijpds-2950	299	10	,	,	PUNCT
ijpds-2950	299	11	sex	sex	NOUN
ijpds-2950	299	12	and	and	CCONJ
ijpds-2950	299	13	apoe	apoe	ADJ
ijpds-2950	299	14	genotype	genotype	NOUN
ijpds-2950	299	15	:	:	PUNCT
ijpds-2950	299	16	a	a	DET
ijpds-2950	299	17	population	population	NOUN
ijpds-2950	299	18	-	-	PUNCT
ijpds-2950	299	19	based	base	VERB
ijpds-2950	299	20	cohort	cohort	NOUN
ijpds-2950	299	21	study	study	NOUN
ijpds-2950	299	22	.	.	PUNCT
ijpds-2950	300	1	cmaj	cmaj	PROPN
ijpds-2950	300	2	.	.	PUNCT
ijpds-2950	300	3	2018:4	2018:4	NUM
ijpds-2950	300	4	;	;	PUNCT
ijpds-2950	300	5	190(35):e1033	190(35):e1033	NUM
ijpds-2950	300	6	-	-	SYM
ijpds-2950	300	7	41	41	NUM
ijpds-2950	300	8	.	.	PUNCT
ijpds-2950	301	1	how	how	SCONJ
ijpds-2950	301	2	to	to	PART
ijpds-2950	301	3	cite	cite	VERB
ijpds-2950	301	4	this	this	DET
ijpds-2950	301	5	article	article	NOUN
ijpds-2950	301	6	:	:	PUNCT
ijpds-2950	301	7	sujeetha	sujeetha	PROPN
ijpds-2950	301	8	purushothaman	purushothaman	NOUN
ijpds-2950	301	9	,	,	PUNCT
ijpds-2950	301	10	arumugan	arumugan	PROPN
ijpds-2950	301	11	vijaya	vijaya	PROPN
ijpds-2950	301	12	anand	anand	PROPN
ijpds-2950	301	13	.	.	PUNCT
ijpds-2950	302	1	the	the	DET
ijpds-2950	302	2	link	link	NOUN
ijpds-2950	302	3	between	between	ADP
ijpds-2950	302	4	cholesterol	cholesterol	NOUN
ijpds-2950	302	5	and	and	CCONJ
ijpds-2950	302	6	a	a	DET
ijpds-2950	302	7	brain	brain	NOUN
ijpds-2950	302	8	disease	disease	NOUN
ijpds-2950	302	9	.	.	PUNCT
ijpds-2950	303	1	indian	indian	PROPN
ijpds-2950	303	2	j	j	PROPN
ijpds-2950	303	3	pharm	pharm	PROPN
ijpds-2950	303	4	drug	drug	PROPN
ijpds-2950	303	5	studies	study	NOUN
ijpds-2950	303	6	.	.	PUNCT
ijpds-2950	303	7	2022	2022	NUM
ijpds-2950	303	8	;	;	PUNCT
ijpds-2950	303	9	1(1	1(1	NUM
ijpds-2950	303	10	):	):	PUNCT
ijpds-2950	303	11	10	10	NUM
ijpds-2950	303	12	-	-	SYM
ijpds-2950	303	13	14	14	NUM
ijpds-2950	303	14	.	.	PUNCT
ijpds-2950	304	1	funding	funding	NOUN
ijpds-2950	304	2	:	:	PUNCT
ijpds-2950	304	3	none	none	NOUN
ijpds-2950	304	4	;	;	PUNCT
ijpds-2950	304	5	conflict	conflict	NOUN
ijpds-2950	304	6	of	of	ADP
ijpds-2950	304	7	interest	interest	NOUN
ijpds-2950	304	8	:	:	PUNCT
ijpds-2950	304	9	none	none	NOUN
ijpds-2950	304	10	stated	state	VERB