id	sid	tid	token	lemma	pos
ijpds-3133	1	1	rai	rai	X
ijpds-3133	1	2	et	et	PROPN
ijpds-3133	1	3	al	al	PROPN
ijpds-3133	1	4	mindful	mindful	ADJ
ijpds-3133	1	5	-	-	PUNCT
ijpds-3133	1	6	based	base	VERB
ijpds-3133	1	7	stress	stress	NOUN
ijpds-3133	1	8	reduction	reduction	NOUN
ijpds-3133	1	9	impact	impact	NOUN
ijpds-3133	1	10	vol	vol	NOUN
ijpds-3133	1	11	1	1	NUM
ijpds-3133	1	12	|	|	NOUN
ijpds-3133	1	13	issue	issue	NOUN
ijpds-3133	1	14	2	2	NUM
ijpds-3133	1	15	|	|	ADV
ijpds-3133	1	16	jul	jul	PROPN
ijpds-3133	1	17	–	–	PUNCT
ijpds-3133	1	18	sep	sep	PROPN
ijpds-3133	1	19	2022	2022	NUM
ijpds-3133	1	20	indian	indian	PROPN
ijpds-3133	1	21	j	j	PROPN
ijpds-3133	1	22	pharm	pharm	PROPN
ijpds-3133	1	23	drug	drug	PROPN
ijpds-3133	1	24	studies	study	NOUN
ijpds-3133	1	25	|	|	ADV
ijpds-3133	1	26	38	38	NUM
ijpds-3133	1	27	review	review	NOUN
ijpds-3133	1	28	article	article	NOUN
ijpds-3133	1	29	advances	advance	VERB
ijpds-3133	1	30	in	in	ADP
ijpds-3133	1	31	ocular	ocular	ADJ
ijpds-3133	1	32	drug	drug	NOUN
ijpds-3133	1	33	delivery	delivery	NOUN
ijpds-3133	1	34	system	system	NOUN
ijpds-3133	1	35	for	for	ADP
ijpds-3133	1	36	glaucoma	glaucoma	NOUN
ijpds-3133	1	37	management	management	NOUN
ijpds-3133	1	38	–	–	PUNCT
ijpds-3133	1	39	a	a	DET
ijpds-3133	1	40	comprehensive	comprehensive	ADJ
ijpds-3133	1	41	review	review	NOUN
ijpds-3133	1	42	raju	raju	PROPN
ijpds-3133	1	43	maski1	maski1	PROPN
ijpds-3133	1	44	,	,	PUNCT
ijpds-3133	1	45	jitendra	jitendra	PROPN
ijpds-3133	1	46	banweer2	banweer2	PROPN
ijpds-3133	1	47	,	,	PUNCT
ijpds-3133	1	48	megha	megha	PROPN
ijpds-3133	1	49	mishra3	mishra3	PROPN
ijpds-3133	1	50	,	,	PUNCT
ijpds-3133	1	51	praveen	praveen	PROPN
ijpds-3133	1	52	tahilani3	tahilani3	PROPN
ijpds-3133	1	53	,	,	PUNCT
ijpds-3133	1	54	gaurav	gaurav	PROPN
ijpds-3133	1	55	goyanar4	goyanar4	PROPN
ijpds-3133	1	56	from	from	ADP
ijpds-3133	1	57	,	,	PUNCT
ijpds-3133	1	58	1m	1m	NUM
ijpds-3133	1	59	-	-	PUNCT
ijpds-3133	1	60	pharma	pharma	PROPN
ijpds-3133	1	61	(	(	PUNCT
ijpds-3133	1	62	pharmaceutics	pharmaceutic	NOUN
ijpds-3133	1	63	)	)	PUNCT
ijpds-3133	1	64	,	,	PUNCT
ijpds-3133	1	65	2sagar	2sagar	NUM
ijpds-3133	1	66	institute	institute	NOUN
ijpds-3133	1	67	of	of	ADP
ijpds-3133	1	68	research	research	PROPN
ijpds-3133	1	69	technology	technology	PROPN
ijpds-3133	1	70	&	&	CCONJ
ijpds-3133	1	71	science	science	PROPN
ijpds-3133	1	72	pharmacy	pharmacy	PROPN
ijpds-3133	1	73	,	,	PUNCT
ijpds-3133	1	74	bhopal	bhopal	NOUN
ijpds-3133	1	75	(	(	PUNCT
ijpds-3133	1	76	m.p	m.p	PROPN
ijpds-3133	1	77	.	.	PROPN
ijpds-3133	1	78	)	)	PUNCT
ijpds-3133	1	79	,	,	PUNCT
ijpds-3133	1	80	3associate	3associate	NUM
ijpds-3133	1	81	professor	professor	NOUN
ijpds-3133	1	82	,	,	PUNCT
ijpds-3133	1	83	sirts	sirts	PROPN
ijpds-3133	1	84	pharmacy	pharmacy	PROPN
ijpds-3133	1	85	college	college	PROPN
ijpds-3133	1	86	,	,	PUNCT
ijpds-3133	1	87	bhopal	bhopal	NOUN
ijpds-3133	1	88	(	(	PUNCT
ijpds-3133	1	89	m.p	m.p	PROPN
ijpds-3133	1	90	.	.	PROPN
ijpds-3133	1	91	)	)	PUNCT
ijpds-3133	1	92	,	,	PUNCT
ijpds-3133	1	93	4department	4department	NUM
ijpds-3133	1	94	of	of	ADP
ijpds-3133	1	95	pharmaceutical	pharmaceutical	ADJ
ijpds-3133	1	96	science	science	NOUN
ijpds-3133	1	97	,	,	PUNCT
ijpds-3133	1	98	sage	sage	NOUN
ijpds-3133	1	99	university	university	NOUN
ijpds-3133	1	100	,	,	PUNCT
ijpds-3133	1	101	indore	indore	PROPN
ijpds-3133	1	102	m.p	m.p	PROPN
ijpds-3133	1	103	.	.	PROPN
ijpds-3133	1	104	correspondence	correspondence	NOUN
ijpds-3133	1	105	to	to	ADP
ijpds-3133	1	106	:	:	PUNCT
ijpds-3133	1	107	raju	raju	PROPN
ijpds-3133	1	108	maski	maski	PROPN
ijpds-3133	1	109	,	,	PUNCT
ijpds-3133	1	110	m	m	NOUN
ijpds-3133	1	111	-	-	NOUN
ijpds-3133	1	112	pharma	pharma	PROPN
ijpds-3133	1	113	(	(	PUNCT
ijpds-3133	1	114	pharmaceutics	pharmaceutic	NOUN
ijpds-3133	1	115	)	)	PUNCT
ijpds-3133	1	116	,	,	PUNCT
ijpds-3133	1	117	sagar	sagar	PROPN
ijpds-3133	1	118	institute	institute	PROPN
ijpds-3133	1	119	of	of	ADP
ijpds-3133	1	120	research	research	PROPN
ijpds-3133	1	121	technology	technology	PROPN
ijpds-3133	1	122	&	&	CCONJ
ijpds-3133	1	123	science	science	PROPN
ijpds-3133	1	124	pharmacy	pharmacy	PROPN
ijpds-3133	1	125	,	,	PUNCT
ijpds-3133	1	126	bhopal	bhopal	NOUN
ijpds-3133	1	127	(	(	PUNCT
ijpds-3133	1	128	m.p	m.p	PROPN
ijpds-3133	1	129	.	.	PROPN
ijpds-3133	1	130	)	)	PUNCT
ijpds-3133	1	131	.	.	PUNCT
ijpds-3133	2	1	email	email	NOUN
ijpds-3133	2	2	:	:	PUNCT
ijpds-3133	3	1	tahilanipraveen@gmail.com	tahilanipraveen@gmail.com	X
ijpds-3133	3	2	abstract	abstract	ADJ
ijpds-3133	3	3	in	in	ADP
ijpds-3133	3	4	today	today	NOUN
ijpds-3133	3	5	’s	’s	PART
ijpds-3133	3	6	world	world	NOUN
ijpds-3133	3	7	delivery	delivery	NOUN
ijpds-3133	3	8	of	of	ADP
ijpds-3133	3	9	ophthalmic	ophthalmic	ADJ
ijpds-3133	3	10	drugs	drug	NOUN
ijpds-3133	3	11	remains	remains	AUX
ijpds-3133	3	12	challenging	challenge	VERB
ijpds-3133	3	13	despite	despite	SCONJ
ijpds-3133	3	14	easy	easy	ADJ
ijpds-3133	3	15	accessibility	accessibility	NOUN
ijpds-3133	3	16	via	via	ADP
ijpds-3133	3	17	the	the	DET
ijpds-3133	3	18	ocular	ocular	ADJ
ijpds-3133	3	19	surface	surface	NOUN
ijpds-3133	3	20	.	.	PUNCT
ijpds-3133	4	1	eye	eye	NOUN
ijpds-3133	4	2	drops	drop	NOUN
ijpds-3133	4	3	are	be	AUX
ijpds-3133	4	4	easy	easy	ADJ
ijpds-3133	4	5	and	and	CCONJ
ijpds-3133	4	6	most	most	ADV
ijpds-3133	4	7	widely	widely	ADV
ijpds-3133	4	8	used	use	VERB
ijpds-3133	4	9	for	for	ADP
ijpds-3133	4	10	drug	drug	NOUN
ijpds-3133	4	11	delivery	delivery	NOUN
ijpds-3133	4	12	for	for	ADP
ijpds-3133	4	13	treating	treat	VERB
ijpds-3133	4	14	ocular	ocular	ADJ
ijpds-3133	4	15	infections	infection	NOUN
ijpds-3133	4	16	,	,	PUNCT
ijpds-3133	4	17	particularly	particularly	ADV
ijpds-3133	4	18	involving	involve	VERB
ijpds-3133	4	19	the	the	DET
ijpds-3133	4	20	internal	internal	ADJ
ijpds-3133	4	21	segment	segment	NOUN
ijpds-3133	4	22	having	have	VERB
ijpds-3133	4	23	an	an	DET
ijpds-3133	4	24	additional	additional	ADJ
ijpds-3133	4	25	benefit	benefit	NOUN
ijpds-3133	4	26	of	of	ADP
ijpds-3133	4	27	avoiding	avoid	VERB
ijpds-3133	4	28	first	first	ADJ
ijpds-3133	4	29	-	-	PUNCT
ijpds-3133	4	30	pass	pass	VERB
ijpds-3133	4	31	metabolism	metabolism	NOUN
ijpds-3133	4	32	there	there	ADV
ijpds-3133	4	33	while	while	SCONJ
ijpds-3133	4	34	passing	pass	VERB
ijpds-3133	4	35	through	through	ADP
ijpds-3133	4	36	the	the	DET
ijpds-3133	4	37	systemic	systemic	ADJ
ijpds-3133	4	38	circulation	circulation	NOUN
ijpds-3133	4	39	.	.	PUNCT
ijpds-3133	5	1	the	the	DET
ijpds-3133	5	2	challenges	challenge	NOUN
ijpds-3133	5	3	of	of	ADP
ijpds-3133	5	4	drug	drug	NOUN
ijpds-3133	5	5	administration	administration	NOUN
ijpds-3133	5	6	through	through	ADP
ijpds-3133	5	7	traditional	traditional	ADJ
ijpds-3133	5	8	methods	method	NOUN
ijpds-3133	5	9	involve	involve	VERB
ijpds-3133	5	10	improper	improper	ADJ
ijpds-3133	5	11	patient	patient	ADJ
ijpds-3133	5	12	education	education	NOUN
ijpds-3133	5	13	for	for	ADP
ijpds-3133	5	14	drug	drug	NOUN
ijpds-3133	5	15	installation	installation	NOUN
ijpds-3133	5	16	techniques	technique	NOUN
ijpds-3133	5	17	,	,	PUNCT
ijpds-3133	5	18	compliance	compliance	NOUN
ijpds-3133	5	19	,	,	PUNCT
ijpds-3133	5	20	adherence	adherence	NOUN
ijpds-3133	5	21	,	,	PUNCT
ijpds-3133	5	22	and	and	CCONJ
ijpds-3133	5	23	persistence	persistence	NOUN
ijpds-3133	5	24	.	.	PUNCT
ijpds-3133	6	1	different	different	ADJ
ijpds-3133	6	2	dynam	dynam	PROPN
ijpds-3133	6	3	ic	ic	PROPN
ijpds-3133	6	4	and	and	CCONJ
ijpds-3133	6	5	static	static	ADJ
ijpds-3133	6	6	ocular	ocular	ADJ
ijpds-3133	6	7	barriers	barrier	NOUN
ijpds-3133	6	8	involved	involve	VERB
ijpds-3133	6	9	only	only	ADV
ijpds-3133	6	10	permit	permit	VERB
ijpds-3133	6	11	limited	limited	ADJ
ijpds-3133	6	12	drug	drug	NOUN
ijpds-3133	6	13	delivery	delivery	NOUN
ijpds-3133	6	14	to	to	ADP
ijpds-3133	6	15	the	the	DET
ijpds-3133	6	16	target	target	NOUN
ijpds-3133	6	17	ocular	ocular	ADJ
ijpds-3133	6	18	tissues	tissue	NOUN
ijpds-3133	6	19	.	.	PUNCT
ijpds-3133	7	1	in	in	ADP
ijpds-3133	7	2	this	this	DET
ijpds-3133	7	3	review	review	NOUN
ijpds-3133	7	4	,	,	PUNCT
ijpds-3133	7	5	we	we	PRON
ijpds-3133	7	6	described	describe	VERB
ijpds-3133	7	7	the	the	DET
ijpds-3133	7	8	development	development	NOUN
ijpds-3133	7	9	of	of	ADP
ijpds-3133	7	10	welltolerated	welltolerate	VERB
ijpds-3133	7	11	drug	drug	NOUN
ijpds-3133	7	12	delivery	delivery	NOUN
ijpds-3133	7	13	systems	system	NOUN
ijpds-3133	7	14	that	that	PRON
ijpds-3133	7	15	helps	help	VERB
ijpds-3133	7	16	to	to	PART
ijpds-3133	7	17	overcome	overcome	VERB
ijpds-3133	7	18	the	the	DET
ijpds-3133	7	19	factors	factor	NOUN
ijpds-3133	7	20	limiting	limit	VERB
ijpds-3133	7	21	adequate	adequate	ADJ
ijpds-3133	7	22	drug	drug	NOUN
ijpds-3133	7	23	delivery	delivery	NOUN
ijpds-3133	7	24	t	t	NOUN
ijpds-3133	7	25	o	o	NOUN
ijpds-3133	7	26	the	the	DET
ijpds-3133	7	27	glaucomatous	glaucomatous	ADJ
ijpds-3133	7	28	patients	patient	NOUN
ijpds-3133	7	29	targeting	target	VERB
ijpds-3133	7	30	infected	infect	VERB
ijpds-3133	7	31	tissues	tissue	NOUN
ijpds-3133	7	32	with	with	ADP
ijpds-3133	7	33	traditional	traditional	ADJ
ijpds-3133	7	34	techniques	technique	NOUN
ijpds-3133	7	35	.	.	PUNCT
ijpds-3133	8	1	keywords	keyword	NOUN
ijpds-3133	8	2	:	:	PUNCT
ijpds-3133	8	3	drug	drug	NOUN
ijpds-3133	8	4	delivery	delivery	NOUN
ijpds-3133	8	5	,	,	PUNCT
ijpds-3133	8	6	glaucomatous	glaucomatous	ADJ
ijpds-3133	8	7	,	,	PUNCT
ijpds-3133	8	8	neuroprotection	neuroprotection	NOUN
ijpds-3133	8	9	,	,	PUNCT
ijpds-3133	8	10	ocular	ocular	ADJ
ijpds-3133	8	11	surfaces	surface	NOUN
ijpds-3133	8	12	,	,	PUNCT
ijpds-3133	8	13	ophthalmic	ophthalmic	ADJ
ijpds-3133	8	14	drugs	drug	NOUN
ijpds-3133	8	15	t	t	PROPN
ijpds-3133	8	16	is	be	AUX
ijpds-3133	8	17	known	know	VERB
ijpds-3133	8	18	that	that	SCONJ
ijpds-3133	8	19	glaucoma	glaucoma	NOUN
ijpds-3133	8	20	is	be	AUX
ijpds-3133	8	21	the	the	DET
ijpds-3133	8	22	second	second	ADJ
ijpds-3133	8	23	most	most	ADV
ijpds-3133	8	24	common	common	ADJ
ijpds-3133	8	25	cause	cause	NOUN
ijpds-3133	8	26	of	of	ADP
ijpds-3133	8	27	blindness	blindness	NOUN
ijpds-3133	8	28	in	in	ADP
ijpds-3133	8	29	the	the	DET
ijpds-3133	8	30	world	world	NOUN
ijpds-3133	8	31	.	.	PUNCT
ijpds-3133	9	1	patients	patient	NOUN
ijpds-3133	9	2	with	with	ADP
ijpds-3133	9	3	glaucoma	glaucoma	NOUN
ijpds-3133	9	4	present	present	ADJ
ijpds-3133	9	5	with	with	ADP
ijpds-3133	9	6	high	high	ADJ
ijpds-3133	9	7	ocular	ocular	ADJ
ijpds-3133	9	8	pressures	pressure	NOUN
ijpds-3133	9	9	that	that	PRON
ijpds-3133	9	10	can	can	AUX
ijpds-3133	9	11	cause	cause	VERB
ijpds-3133	9	12	optic	optic	ADJ
ijpds-3133	9	13	neuropathy	neuropathy	ADJ
ijpds-3133	9	14	precipitating	precipitating	NOUN
ijpds-3133	9	15	in	in	ADP
ijpds-3133	9	16	the	the	DET
ijpds-3133	9	17	corresponding	corresponding	ADJ
ijpds-3133	9	18	visual	visual	ADJ
ijpds-3133	9	19	field	field	NOUN
ijpds-3133	9	20	loss	loss	NOUN
ijpds-3133	9	21	[	[	X
ijpds-3133	9	22	1	1	NUM
ijpds-3133	9	23	]	]	PUNCT
ijpds-3133	9	24	.	.	PUNCT
ijpds-3133	10	1	recent	recent	ADJ
ijpds-3133	10	2	studies	study	NOUN
ijpds-3133	10	3	showed	show	VERB
ijpds-3133	10	4	there	there	PRON
ijpds-3133	10	5	were	be	VERB
ijpds-3133	10	6	about	about	ADV
ijpds-3133	10	7	60	60	NUM
ijpds-3133	10	8	million	million	NUM
ijpds-3133	10	9	people	people	NOUN
ijpds-3133	10	10	having	have	VERB
ijpds-3133	10	11	optic	optic	ADJ
ijpds-3133	10	12	neuropathy	neuropathy	ADJ
ijpds-3133	10	13	secondary	secondary	ADJ
ijpds-3133	10	14	to	to	ADP
ijpds-3133	10	15	glaucoma	glaucoma	NOUN
ijpds-3133	10	16	globally	globally	ADV
ijpds-3133	11	1	[	[	X
ijpds-3133	11	2	2	2	NUM
ijpds-3133	11	3	]	]	PUNCT
ijpds-3133	11	4	.	.	PUNCT
ijpds-3133	12	1	these	these	DET
ijpds-3133	12	2	studies	study	NOUN
ijpds-3133	12	3	have	have	AUX
ijpds-3133	12	4	shown	show	VERB
ijpds-3133	12	5	that	that	PRON
ijpds-3133	12	6	primary	primary	ADJ
ijpds-3133	12	7	openangle	openangle	NOUN
ijpds-3133	12	8	glaucoma	glaucoma	NOUN
ijpds-3133	12	9	(	(	PUNCT
ijpds-3133	12	10	poag	poag	PROPN
ijpds-3133	12	11	)	)	PUNCT
ijpds-3133	12	12	leads	lead	VERB
ijpds-3133	12	13	to	to	ADP
ijpds-3133	12	14	bilateral	bilateral	ADJ
ijpds-3133	12	15	blindness	blindness	NOUN
ijpds-3133	12	16	in	in	ADP
ijpds-3133	12	17	9	9	NUM
ijpds-3133	12	18	%	%	NOUN
ijpds-3133	12	19	of	of	ADP
ijpds-3133	12	20	patients	patient	NOUN
ijpds-3133	12	21	and	and	CCONJ
ijpds-3133	12	22	unilateral	unilateral	ADJ
ijpds-3133	12	23	blindness	blindness	NOUN
ijpds-3133	12	24	in	in	ADP
ijpds-3133	12	25	27	27	NUM
ijpds-3133	12	26	%	%	NOUN
ijpds-3133	12	27	of	of	ADP
ijpds-3133	12	28	patients	patient	NOUN
ijpds-3133	12	29	,	,	PUNCT
ijpds-3133	12	30	within	within	ADP
ijpds-3133	12	31	20	20	NUM
ijpds-3133	12	32	years	year	NOUN
ijpds-3133	12	33	of	of	ADP
ijpds-3133	12	34	the	the	DET
ijpds-3133	12	35	first	first	ADJ
ijpds-3133	12	36	glaucomatous	glaucomatous	ADJ
ijpds-3133	12	37	changes	change	NOUN
ijpds-3133	12	38	[	[	X
ijpds-3133	12	39	3	3	NUM
ijpds-3133	12	40	]	]	PUNCT
ijpds-3133	12	41	.	.	PUNCT
ijpds-3133	13	1	during	during	ADP
ijpds-3133	13	2	2010	2010	NUM
ijpds-3133	13	3	,	,	PUNCT
ijpds-3133	13	4	an	an	DET
ijpds-3133	13	5	estimated	estimate	VERB
ijpds-3133	13	6	4.5	4.5	NUM
ijpds-3133	13	7	and	and	CCONJ
ijpds-3133	13	8	3.9	3.9	NUM
ijpds-3133	13	9	million	million	NUM
ijpds-3133	13	10	people	people	NOUN
ijpds-3133	13	11	were	be	AUX
ijpds-3133	13	12	diagnosed	diagnose	VERB
ijpds-3133	13	13	with	with	ADP
ijpds-3133	13	14	bilateral	bilateral	ADJ
ijpds-3133	13	15	blindness	blindness	NOUN
ijpds-3133	13	16	due	due	ADP
ijpds-3133	13	17	to	to	ADP
ijpds-3133	13	18	open	open	ADJ
ijpds-3133	13	19	-	-	PUNCT
ijpds-3133	13	20	angle	angle	NOUN
ijpds-3133	13	21	glaucoma	glaucoma	NOUN
ijpds-3133	13	22	(	(	PUNCT
ijpds-3133	13	23	oag	oag	PROPN
ijpds-3133	13	24	)	)	PUNCT
ijpds-3133	13	25	and	and	CCONJ
ijpds-3133	13	26	angle	angle	NOUN
ijpds-3133	13	27	-	-	PUNCT
ijpds-3133	13	28	closure	closure	NOUN
ijpds-3133	13	29	glaucoma	glaucoma	NOUN
ijpds-3133	13	30	(	(	PUNCT
ijpds-3133	13	31	acg	acg	PROPN
ijpds-3133	13	32	)	)	PUNCT
ijpds-3133	13	33	,	,	PUNCT
ijpds-3133	13	34	respectively	respectively	ADV
ijpds-3133	13	35	.	.	PUNCT
ijpds-3133	14	1	the	the	DET
ijpds-3133	14	2	number	number	NOUN
ijpds-3133	14	3	increased	increase	VERB
ijpds-3133	14	4	to	to	ADP
ijpds-3133	14	5	5.9	5.9	NUM
ijpds-3133	14	6	and	and	CCONJ
ijpds-3133	14	7	5.3	5.3	NUM
ijpds-3133	14	8	million	million	NUM
ijpds-3133	14	9	in	in	ADP
ijpds-3133	14	10	the	the	DET
ijpds-3133	14	11	year	year	NOUN
ijpds-3133	14	12	2020	2020	NUM
ijpds-3133	14	13	of	of	ADP
ijpds-3133	14	14	bilaterally	bilaterally	ADV
ijpds-3133	14	15	blind	blind	ADJ
ijpds-3133	14	16	people	people	NOUN
ijpds-3133	14	17	due	due	ADJ
ijpds-3133	14	18	to	to	ADP
ijpds-3133	14	19	oag	oag	VERB
ijpds-3133	14	20	and	and	CCONJ
ijpds-3133	14	21	acg	acg	VERB
ijpds-3133	14	22	[	[	X
ijpds-3133	14	23	2	2	NUM
ijpds-3133	14	24	]	]	PUNCT
ijpds-3133	14	25	.	.	PUNCT
ijpds-3133	15	1	glaucoma	glaucoma	NOUN
ijpds-3133	15	2	is	be	AUX
ijpds-3133	15	3	progressive	progressive	ADJ
ijpds-3133	15	4	and	and	CCONJ
ijpds-3133	15	5	irreversible	irreversible	ADJ
ijpds-3133	15	6	due	due	ADP
ijpds-3133	15	7	to	to	ADP
ijpds-3133	15	8	which	which	PRON
ijpds-3133	15	9	visual	visual	ADJ
ijpds-3133	15	10	field	field	NOUN
ijpds-3133	15	11	loss	loss	NOUN
ijpds-3133	15	12	;	;	PUNCT
ijpds-3133	15	13	however	however	ADV
ijpds-3133	15	14	,	,	PUNCT
ijpds-3133	15	15	attaining	attain	VERB
ijpds-3133	15	16	the	the	DET
ijpds-3133	15	17	normal	normal	ADJ
ijpds-3133	15	18	range	range	NOUN
ijpds-3133	15	19	of	of	ADP
ijpds-3133	15	20	the	the	DET
ijpds-3133	15	21	target	target	NOUN
ijpds-3133	15	22	intraocular	intraocular	ADJ
ijpds-3133	15	23	pressure	pressure	NOUN
ijpds-3133	15	24	(	(	PUNCT
ijpds-3133	15	25	iop	iop	NOUN
ijpds-3133	15	26	)	)	PUNCT
ijpds-3133	15	27	within	within	ADP
ijpds-3133	15	28	alleviates	alleviate	VERB
ijpds-3133	15	29	the	the	DET
ijpds-3133	15	30	progression	progression	NOUN
ijpds-3133	15	31	of	of	ADP
ijpds-3133	15	32	visual	visual	ADJ
ijpds-3133	15	33	field	field	NOUN
ijpds-3133	15	34	loss	loss	NOUN
ijpds-3133	15	35	.	.	PUNCT
ijpds-3133	16	1	the	the	DET
ijpds-3133	16	2	initial	initial	ADJ
ijpds-3133	16	3	management	management	NOUN
ijpds-3133	16	4	strategy	strategy	NOUN
ijpds-3133	16	5	for	for	ADP
ijpds-3133	16	6	‘	'	PUNCT
ijpds-3133	16	7	high	high	ADJ
ijpds-3133	16	8	-	-	PUNCT
ijpds-3133	16	9	risk	risk	NOUN
ijpds-3133	16	10	’	'	PUNCT
ijpds-3133	16	11	glaucoma	glaucoma	NOUN
ijpds-3133	16	12	suspect	suspect	NOUN
ijpds-3133	16	13	or	or	CCONJ
ijpds-3133	16	14	a	a	DET
ijpds-3133	16	15	patient	patient	NOUN
ijpds-3133	16	16	diagnosed	diagnose	VERB
ijpds-3133	16	17	with	with	ADP
ijpds-3133	16	18	oag	oag	PROPN
ijpds-3133	16	19	using	use	VERB
ijpds-3133	16	20	topical	topical	ADJ
ijpds-3133	16	21	anti	anti	ADJ
ijpds-3133	16	22	-	-	ADJ
ijpds-3133	16	23	glaucoma	glaucoma	ADJ
ijpds-3133	16	24	drugs	drug	NOUN
ijpds-3133	16	25	and	and	CCONJ
ijpds-3133	16	26	lowering	lower	VERB
ijpds-3133	16	27	the	the	DET
ijpds-3133	16	28	iop	iop	PROPN
ijpds-3133	16	29	.	.	PUNCT
ijpds-3133	16	30	glaucoma	glaucoma	PROPN
ijpds-3133	16	31	is	be	AUX
ijpds-3133	16	32	a	a	DET
ijpds-3133	16	33	slowly	slowly	ADV
ijpds-3133	16	34	progressive	progressive	ADJ
ijpds-3133	16	35	pathology	pathology	NOUN
ijpds-3133	16	36	that	that	PRON
ijpds-3133	16	37	can	can	AUX
ijpds-3133	16	38	result	result	VERB
ijpds-3133	16	39	in	in	ADP
ijpds-3133	16	40	the	the	DET
ijpds-3133	16	41	loss	loss	NOUN
ijpds-3133	16	42	of	of	ADP
ijpds-3133	16	43	peripheral	peripheral	ADJ
ijpds-3133	16	44	vision	vision	NOUN
ijpds-3133	16	45	,	,	PUNCT
ijpds-3133	16	46	decreased	decrease	VERB
ijpds-3133	16	47	contrast	contrast	NOUN
ijpds-3133	16	48	sensitivity	sensitivity	NOUN
ijpds-3133	16	49	,	,	PUNCT
ijpds-3133	16	50	and	and	CCONJ
ijpds-3133	16	51	loss	loss	NOUN
ijpds-3133	16	52	of	of	ADP
ijpds-3133	16	53	visual	visual	ADJ
ijpds-3133	16	54	acuity	acuity	NOUN
ijpds-3133	16	55	.	.	PUNCT
ijpds-3133	17	1	due	due	ADP
ijpds-3133	17	2	to	to	ADP
ijpds-3133	17	3	the	the	DET
ijpds-3133	17	4	asymptomatic	asymptomatic	ADJ
ijpds-3133	17	5	nature	nature	NOUN
ijpds-3133	17	6	of	of	ADP
ijpds-3133	17	7	the	the	DET
ijpds-3133	17	8	early	early	ADJ
ijpds-3133	17	9	phases	phase	NOUN
ijpds-3133	17	10	of	of	ADP
ijpds-3133	17	11	the	the	DET
ijpds-3133	17	12	disease	disease	NOUN
ijpds-3133	17	13	most	most	ADJ
ijpds-3133	17	14	patients	patient	NOUN
ijpds-3133	17	15	experience	experience	VERB
ijpds-3133	17	16	undiagnosed	undiagnosed	ADJ
ijpds-3133	17	17	loss	loss	NOUN
ijpds-3133	17	18	of	of	ADP
ijpds-3133	17	19	vision	vision	NOUN
ijpds-3133	17	20	until	until	SCONJ
ijpds-3133	17	21	the	the	DET
ijpds-3133	17	22	advanced	advanced	ADJ
ijpds-3133	17	23	stages	stage	NOUN
ijpds-3133	17	24	of	of	ADP
ijpds-3133	17	25	the	the	DET
ijpds-3133	17	26	disease	disease	NOUN
ijpds-3133	17	27	have	have	AUX
ijpds-3133	17	28	occurred	occur	VERB
ijpds-3133	17	29	.	.	PUNCT
ijpds-3133	18	1	thus	thus	ADV
ijpds-3133	18	2	the	the	DET
ijpds-3133	18	3	disease	disease	NOUN
ijpds-3133	18	4	is	be	AUX
ijpds-3133	18	5	known	know	VERB
ijpds-3133	18	6	as	as	ADP
ijpds-3133	18	7	the	the	DET
ijpds-3133	18	8	“	"	PUNCT
ijpds-3133	18	9	silent	silent	ADJ
ijpds-3133	18	10	thief	thief	NOUN
ijpds-3133	18	11	of	of	ADP
ijpds-3133	18	12	sight	sight	NOUN
ijpds-3133	18	13	”	"	PUNCT
ijpds-3133	18	14	.	.	PUNCT
ijpds-3133	19	1	this	this	DET
ijpds-3133	19	2	indolent	indolent	ADJ
ijpds-3133	19	3	optic	optic	NOUN
ijpds-3133	19	4	neuropathy	neuropathy	ADJ
ijpds-3133	19	5	is	be	AUX
ijpds-3133	19	6	characterized	characterize	VERB
ijpds-3133	19	7	structurally	structurally	ADV
ijpds-3133	19	8	by	by	ADP
ijpds-3133	19	9	a	a	DET
ijpds-3133	19	10	loss	loss	NOUN
ijpds-3133	19	11	of	of	ADP
ijpds-3133	19	12	retinal	retinal	ADJ
ijpds-3133	19	13	ganglion	ganglion	NOUN
ijpds-3133	19	14	cells	cell	NOUN
ijpds-3133	19	15	and	and	CCONJ
ijpds-3133	19	16	optic	optic	ADJ
ijpds-3133	19	17	nerve	nerve	NOUN
ijpds-3133	19	18	axons	axon	NOUN
ijpds-3133	19	19	.	.	PUNCT
ijpds-3133	20	1	glaucoma	glaucoma	NOUN
ijpds-3133	20	2	is	be	AUX
ijpds-3133	20	3	the	the	DET
ijpds-3133	20	4	second	second	ADJ
ijpds-3133	20	5	leading	lead	VERB
ijpds-3133	20	6	cause	cause	NOUN
ijpds-3133	20	7	of	of	ADP
ijpds-3133	20	8	the	the	DET
ijpds-3133	20	9	world	world	NOUN
ijpds-3133	20	10	’s	’s	PART
ijpds-3133	20	11	blindness	blindness	NOUN
ijpds-3133	20	12	with	with	ADP
ijpds-3133	20	13	nearly	nearly	ADV
ijpds-3133	20	14	70	70	NUM
ijpds-3133	20	15	million	million	NUM
ijpds-3133	20	16	cases	case	NOUN
ijpds-3133	20	17	worldwide	worldwide	ADV
ijpds-3133	20	18	and	and	CCONJ
ijpds-3133	20	19	accounting	account	VERB
ijpds-3133	20	20	for	for	ADP
ijpds-3133	20	21	12	12	NUM
ijpds-3133	20	22	%	%	NOUN
ijpds-3133	20	23	of	of	ADP
ijpds-3133	20	24	all	all	DET
ijpds-3133	20	25	cases	case	NOUN
ijpds-3133	20	26	of	of	ADP
ijpds-3133	20	27	preventable	preventable	ADJ
ijpds-3133	20	28	blindness	blindness	NOUN
ijpds-3133	20	29	.	.	PUNCT
ijpds-3133	21	1	it	it	PRON
ijpds-3133	21	2	is	be	AUX
ijpds-3133	21	3	estimated	estimate	VERB
ijpds-3133	21	4	that	that	SCONJ
ijpds-3133	21	5	by	by	ADP
ijpds-3133	21	6	2020	2020	NUM
ijpds-3133	21	7	,	,	PUNCT
ijpds-3133	21	8	close	close	ADJ
ijpds-3133	21	9	to	to	PART
ijpds-3133	21	10	4	4	NUM
ijpds-3133	21	11	million	million	NUM
ijpds-3133	21	12	americans	americans	PROPN
ijpds-3133	21	13	will	will	AUX
ijpds-3133	21	14	have	have	VERB
ijpds-3133	21	15	glaucoma	glaucoma	NOUN
ijpds-3133	21	16	with	with	ADP
ijpds-3133	21	17	50	50	NUM
ijpds-3133	21	18	%	%	NOUN
ijpds-3133	21	19	undiagnosed	undiagnosed	ADJ
ijpds-3133	21	20	and	and	CCONJ
ijpds-3133	21	21	approximately	approximately	ADV
ijpds-3133	21	22	120,000	120,000	NUM
ijpds-3133	21	23	individuals	individual	NOUN
ijpds-3133	21	24	developing	develop	VERB
ijpds-3133	21	25	blindness	blindness	NOUN
ijpds-3133	21	26	[	[	X
ijpds-3133	21	27	4].in	4].in	NUM
ijpds-3133	21	28	developing	develop	VERB
ijpds-3133	21	29	countries	country	NOUN
ijpds-3133	21	30	,	,	PUNCT
ijpds-3133	21	31	where	where	SCONJ
ijpds-3133	21	32	the	the	DET
ijpds-3133	21	33	access	access	NOUN
ijpds-3133	21	34	to	to	ADP
ijpds-3133	21	35	adequate	adequate	ADJ
ijpds-3133	21	36	care	care	NOUN
ijpds-3133	21	37	and	and	CCONJ
ijpds-3133	21	38	therapies	therapy	NOUN
ijpds-3133	21	39	is	be	AUX
ijpds-3133	21	40	limited	limited	ADJ
ijpds-3133	21	41	,	,	PUNCT
ijpds-3133	21	42	people	people	NOUN
ijpds-3133	21	43	are	be	AUX
ijpds-3133	21	44	going	go	VERB
ijpds-3133	21	45	blind	blind	ADJ
ijpds-3133	21	46	from	from	ADP
ijpds-3133	21	47	a	a	DET
ijpds-3133	21	48	disease	disease	NOUN
ijpds-3133	21	49	that	that	PRON
ijpds-3133	21	50	can	can	AUX
ijpds-3133	21	51	be	be	AUX
ijpds-3133	21	52	successfully	successfully	ADV
ijpds-3133	21	53	treated	treat	VERB
ijpds-3133	21	54	.	.	PUNCT
ijpds-3133	22	1	patients	patient	NOUN
ijpds-3133	22	2	in	in	ADP
ijpds-3133	22	3	these	these	DET
ijpds-3133	22	4	countries	country	NOUN
ijpds-3133	22	5	may	may	AUX
ijpds-3133	22	6	not	not	PART
ijpds-3133	22	7	have	have	VERB
ijpds-3133	22	8	the	the	DET
ijpds-3133	22	9	ability	ability	NOUN
ijpds-3133	22	10	to	to	PART
ijpds-3133	22	11	get	get	VERB
ijpds-3133	22	12	to	to	ADP
ijpds-3133	22	13	their	their	PRON
ijpds-3133	22	14	clinics	clinic	NOUN
ijpds-3133	22	15	routinely	routinely	ADV
ijpds-3133	22	16	for	for	ADP
ijpds-3133	22	17	refills	refill	NOUN
ijpds-3133	22	18	and	and	CCONJ
ijpds-3133	22	19	exams	exam	NOUN
ijpds-3133	22	20	.	.	PUNCT
ijpds-3133	23	1	however	however	ADV
ijpds-3133	23	2	,	,	PUNCT
ijpds-3133	23	3	even	even	ADV
ijpds-3133	23	4	in	in	ADP
ijpds-3133	23	5	the	the	DET
ijpds-3133	23	6	us	we	PRON
ijpds-3133	23	7	with	with	ADP
ijpds-3133	23	8	ready	ready	ADJ
ijpds-3133	23	9	access	access	NOUN
ijpds-3133	23	10	to	to	ADP
ijpds-3133	23	11	medical	medical	ADJ
ijpds-3133	23	12	care	care	NOUN
ijpds-3133	23	13	and	and	CCONJ
ijpds-3133	23	14	pharmaceuticals	pharmaceutical	NOUN
ijpds-3133	23	15	,	,	PUNCT
ijpds-3133	23	16	glaucoma	glaucoma	NOUN
ijpds-3133	23	17	continues	continue	VERB
ijpds-3133	23	18	to	to	PART
ijpds-3133	23	19	progress	progress	VERB
ijpds-3133	23	20	in	in	ADP
ijpds-3133	23	21	many	many	ADJ
ijpds-3133	23	22	patients	patient	NOUN
ijpds-3133	23	23	.	.	PUNCT
ijpds-3133	24	1	often	often	ADV
ijpds-3133	24	2	poor	poor	ADJ
ijpds-3133	24	3	iop	iop	NOUN
ijpds-3133	24	4	control	control	NOUN
ijpds-3133	24	5	is	be	AUX
ijpds-3133	24	6	due	due	ADJ
ijpds-3133	24	7	to	to	ADP
ijpds-3133	24	8	poor	poor	ADJ
ijpds-3133	24	9	compliance	compliance	NOUN
ijpds-3133	24	10	and	and	CCONJ
ijpds-3133	24	11	adherence	adherence	NOUN
ijpds-3133	24	12	to	to	ADP
ijpds-3133	24	13	daily	daily	ADJ
ijpds-3133	24	14	topical	topical	ADJ
ijpds-3133	24	15	treatment	treatment	NOUN
ijpds-3133	24	16	regimens	regimen	NOUN
ijpds-3133	24	17	or	or	CCONJ
ijpds-3133	24	18	inadequate	inadequate	ADJ
ijpds-3133	24	19	,	,	PUNCT
ijpds-3133	24	20	complex	complex	ADJ
ijpds-3133	24	21	dosing	dosing	ADJ
ijpds-3133	24	22	regimens	regimen	NOUN
ijpds-3133	24	23	.	.	PUNCT
ijpds-3133	25	1	despite	despite	SCONJ
ijpds-3133	25	2	effective	effective	ADJ
ijpds-3133	25	3	monotherapy	monotherapy	NOUN
ijpds-3133	25	4	agents	agent	NOUN
ijpds-3133	25	5	,	,	PUNCT
ijpds-3133	25	6	data	datum	NOUN
ijpds-3133	25	7	has	have	AUX
ijpds-3133	25	8	shown	show	VERB
ijpds-3133	25	9	that	that	SCONJ
ijpds-3133	25	10	upwards	upwards	ADV
ijpds-3133	25	11	of	of	ADP
ijpds-3133	25	12	40	40	NUM
ijpds-3133	25	13	%	%	NOUN
ijpds-3133	25	14	of	of	ADP
ijpds-3133	25	15	oag	oag	PROPN
ijpds-3133	25	16	patients	patient	NOUN
ijpds-3133	25	17	require	require	VERB
ijpds-3133	25	18	combination	combination	NOUN
ijpds-3133	25	19	therapy	therapy	NOUN
ijpds-3133	25	20	for	for	ADP
ijpds-3133	25	21	iop	iop	NOUN
ijpds-3133	25	22	reduction	reduction	NOUN
ijpds-3133	25	23	with	with	ADP
ijpds-3133	25	24	close	close	ADJ
ijpds-3133	25	25	to	to	PART
ijpds-3133	25	26	75	75	NUM
ijpds-3133	25	27	%	%	NOUN
ijpds-3133	25	28	of	of	ADP
ijpds-3133	25	29	glaucoma	glaucoma	NOUN
ijpds-3133	25	30	patients	patient	NOUN
ijpds-3133	25	31	requiring	require	VERB
ijpds-3133	25	32	adjunctive	adjunctive	ADJ
ijpds-3133	25	33	therapy	therapy	NOUN
ijpds-3133	25	34	after	after	ADP
ijpds-3133	25	35	five	five	NUM
ijpds-3133	25	36	years	year	NOUN
ijpds-3133	25	37	.	.	PUNCT
ijpds-3133	26	1	the	the	DET
ijpds-3133	26	2	complexity	complexity	NOUN
ijpds-3133	26	3	,	,	PUNCT
ijpds-3133	26	4	cost	cost	NOUN
ijpds-3133	26	5	,	,	PUNCT
ijpds-3133	26	6	and	and	CCONJ
ijpds-3133	26	7	administration	administration	NOUN
ijpds-3133	26	8	issues	issue	NOUN
ijpds-3133	26	9	with	with	ADP
ijpds-3133	26	10	multiple	multiple	ADJ
ijpds-3133	26	11	medications	medication	NOUN
ijpds-3133	26	12	further	far	ADV
ijpds-3133	26	13	reduce	reduce	VERB
ijpds-3133	26	14	patient	patient	ADJ
ijpds-3133	26	15	compliance	compliance	NOUN
ijpds-3133	26	16	and	and	CCONJ
ijpds-3133	26	17	adherence	adherence	NOUN
ijpds-3133	26	18	.	.	PUNCT
ijpds-3133	27	1	prescribing	prescribing	NOUN
ijpds-3133	27	2	pharmacy	pharmacy	NOUN
ijpds-3133	27	3	claims	claim	VERB
ijpds-3133	27	4	data	datum	NOUN
ijpds-3133	27	5	show	show	VERB
ijpds-3133	27	6	the	the	DET
ijpds-3133	27	7	vast	vast	ADJ
ijpds-3133	27	8	majority	majority	NOUN
ijpds-3133	27	9	of	of	ADP
ijpds-3133	27	10	patients	patient	NOUN
ijpds-3133	27	11	do	do	AUX
ijpds-3133	27	12	not	not	PART
ijpds-3133	27	13	take	take	VERB
ijpds-3133	27	14	their	their	PRON
ijpds-3133	27	15	i	i	NOUN
ijpds-3133	27	16	mailto:tahilanipraveen@gmail.com	mailto:tahilanipraveen@gmail.com	X
ijpds-3133	28	1	rai	rai	X
ijpds-3133	28	2	et	et	PROPN
ijpds-3133	28	3	al	al	PROPN
ijpds-3133	28	4	mindful	mindful	ADJ
ijpds-3133	28	5	-	-	PUNCT
ijpds-3133	28	6	based	base	VERB
ijpds-3133	28	7	stress	stress	NOUN
ijpds-3133	28	8	reduction	reduction	NOUN
ijpds-3133	28	9	impact	impact	NOUN
ijpds-3133	28	10	vol	vol	NOUN
ijpds-3133	28	11	1	1	NUM
ijpds-3133	28	12	|	|	NOUN
ijpds-3133	28	13	issue	issue	NOUN
ijpds-3133	28	14	2	2	NUM
ijpds-3133	28	15	|	|	ADV
ijpds-3133	28	16	jul	jul	PROPN
ijpds-3133	28	17	–	–	PUNCT
ijpds-3133	28	18	sep	sep	PROPN
ijpds-3133	28	19	2022	2022	NUM
ijpds-3133	28	20	indian	indian	PROPN
ijpds-3133	28	21	j	j	PROPN
ijpds-3133	28	22	pharm	pharm	PROPN
ijpds-3133	28	23	drug	drug	PROPN
ijpds-3133	28	24	studies	study	NOUN
ijpds-3133	28	25	|	|	ADV
ijpds-3133	28	26	39	39	NUM
ijpds-3133	28	27	topical	topical	ADJ
ijpds-3133	28	28	medications	medication	NOUN
ijpds-3133	28	29	or	or	CCONJ
ijpds-3133	28	30	renew	renew	VERB
ijpds-3133	28	31	their	their	PRON
ijpds-3133	28	32	prescriptions	prescription	NOUN
ijpds-3133	28	33	,	,	PUNCT
ijpds-3133	28	34	resulting	result	VERB
ijpds-3133	28	35	in	in	ADP
ijpds-3133	28	36	patients	patient	NOUN
ijpds-3133	28	37	regularly	regularly	ADV
ijpds-3133	28	38	missing	miss	VERB
ijpds-3133	28	39	doses	dose	NOUN
ijpds-3133	28	40	.	.	PUNCT
ijpds-3133	29	1	retrospective	retrospective	ADJ
ijpds-3133	29	2	populationbased	populationbase	VERB
ijpds-3133	29	3	data	datum	NOUN
ijpds-3133	29	4	suggests	suggest	VERB
ijpds-3133	29	5	a	a	DET
ijpds-3133	29	6	minority	minority	NOUN
ijpds-3133	29	7	of	of	ADP
ijpds-3133	29	8	patients	patient	NOUN
ijpds-3133	29	9	consistently	consistently	ADV
ijpds-3133	29	10	adhere	adhere	VERB
ijpds-3133	29	11	to	to	ADP
ijpds-3133	29	12	their	their	PRON
ijpds-3133	29	13	topical	topical	ADJ
ijpds-3133	29	14	medication	medication	NOUN
ijpds-3133	29	15	.	.	PUNCT
ijpds-3133	30	1	a	a	DET
ijpds-3133	30	2	sustained	sustained	ADJ
ijpds-3133	30	3	mode	mode	NOUN
ijpds-3133	30	4	of	of	ADP
ijpds-3133	30	5	delivery	delivery	NOUN
ijpds-3133	30	6	where	where	SCONJ
ijpds-3133	30	7	the	the	DET
ijpds-3133	30	8	patient	patient	NOUN
ijpds-3133	30	9	’s	’s	PART
ijpds-3133	30	10	dependence	dependence	NOUN
ijpds-3133	30	11	on	on	ADP
ijpds-3133	30	12	daily	daily	ADJ
ijpds-3133	30	13	self	self	NOUN
ijpds-3133	30	14	-	-	PUNCT
ijpds-3133	30	15	instillation	instillation	NOUN
ijpds-3133	30	16	is	be	AUX
ijpds-3133	30	17	eliminated	eliminate	VERB
ijpds-3133	30	18	could	could	AUX
ijpds-3133	30	19	dramatically	dramatically	ADV
ijpds-3133	30	20	improve	improve	VERB
ijpds-3133	30	21	these	these	DET
ijpds-3133	30	22	statistics	statistic	NOUN
ijpds-3133	31	1	[	[	X
ijpds-3133	31	2	8	8	NUM
ijpds-3133	31	3	]	]	PUNCT
ijpds-3133	31	4	.	.	PUNCT
ijpds-3133	32	1	various	various	ADJ
ijpds-3133	32	2	studies	study	NOUN
ijpds-3133	32	3	have	have	AUX
ijpds-3133	32	4	highlighted	highlight	VERB
ijpds-3133	32	5	the	the	DET
ijpds-3133	32	6	shortcomings	shortcoming	NOUN
ijpds-3133	32	7	of	of	ADP
ijpds-3133	32	8	treatment	treatment	NOUN
ijpds-3133	32	9	regimens	regimen	NOUN
ijpds-3133	32	10	,	,	PUNCT
ijpds-3133	32	11	drug	drug	NOUN
ijpds-3133	32	12	efficacy	efficacy	NOUN
ijpds-3133	32	13	factors	factor	NOUN
ijpds-3133	32	14	causing	cause	VERB
ijpds-3133	32	15	short	short	ADJ
ijpds-3133	32	16	precorneal	precorneal	NOUN
ijpds-3133	32	17	residence	residence	NOUN
ijpds-3133	32	18	time	time	NOUN
ijpds-3133	32	19	,	,	PUNCT
ijpds-3133	32	20	reduced	reduce	VERB
ijpds-3133	32	21	absorption	absorption	NOUN
ijpds-3133	32	22	,	,	PUNCT
ijpds-3133	32	23	and	and	CCONJ
ijpds-3133	32	24	rapid	rapid	ADJ
ijpds-3133	32	25	turnover	turnover	NOUN
ijpds-3133	32	26	of	of	ADP
ijpds-3133	32	27	lacrimal	lacrimal	ADJ
ijpds-3133	32	28	fluid	fluid	NOUN
ijpds-3133	32	29	,	,	PUNCT
ijpds-3133	32	30	extensive	extensive	ADJ
ijpds-3133	32	31	nasolacrimal	nasolacrimal	ADJ
ijpds-3133	32	32	drainage	drainage	NOUN
ijpds-3133	32	33	,	,	PUNCT
ijpds-3133	32	34	rapid	rapid	ADJ
ijpds-3133	32	35	blinking	blink	VERB
ijpds-3133	32	36	reflex	reflex	NOUN
ijpds-3133	32	37	,	,	PUNCT
ijpds-3133	32	38	human	human	ADJ
ijpds-3133	32	39	factors	factor	NOUN
ijpds-3133	32	40	compliance	compliance	NOUN
ijpds-3133	32	41	,	,	PUNCT
ijpds-3133	32	42	and	and	CCONJ
ijpds-3133	32	43	persistence	persistence	NOUN
ijpds-3133	32	44	[	[	X
ijpds-3133	32	45	5	5	NUM
ijpds-3133	32	46	-	-	SYM
ijpds-3133	32	47	7	7	NUM
ijpds-3133	32	48	]	]	PUNCT
ijpds-3133	32	49	.	.	PUNCT
ijpds-3133	33	1	methods	method	NOUN
ijpds-3133	33	2	for	for	ADP
ijpds-3133	33	3	this	this	DET
ijpds-3133	33	4	review	review	NOUN
ijpds-3133	33	5	article	article	NOUN
ijpds-3133	33	6	we	we	PRON
ijpds-3133	33	7	searched	search	VERB
ijpds-3133	33	8	different	different	ADJ
ijpds-3133	33	9	electronic	electronic	ADJ
ijpds-3133	33	10	databases	database	NOUN
ijpds-3133	33	11	such	such	ADJ
ijpds-3133	33	12	as	as	ADP
ijpds-3133	33	13	pubmed	pubmed	PROPN
ijpds-3133	33	14	,	,	PUNCT
ijpds-3133	33	15	google	google	PROPN
ijpds-3133	33	16	scholar	scholar	NOUN
ijpds-3133	33	17	.	.	PUNCT
ijpds-3133	34	1	studies	study	NOUN
ijpds-3133	34	2	were	be	AUX
ijpds-3133	34	3	included	include	VERB
ijpds-3133	34	4	from	from	ADP
ijpds-3133	34	5	1975	1975	NUM
ijpds-3133	34	6	to	to	ADP
ijpds-3133	34	7	2020	2020	NUM
ijpds-3133	34	8	available	available	ADJ
ijpds-3133	34	9	in	in	ADP
ijpds-3133	34	10	the	the	DET
ijpds-3133	34	11	english	english	ADJ
ijpds-3133	34	12	language	language	NOUN
ijpds-3133	34	13	only	only	ADV
ijpds-3133	34	14	.	.	PUNCT
ijpds-3133	35	1	ocular	ocular	ADJ
ijpds-3133	35	2	insertsfor	insertsfor	ADP
ijpds-3133	35	3	the	the	DET
ijpds-3133	35	4	release	release	NOUN
ijpds-3133	35	5	of	of	ADP
ijpds-3133	35	6	therapeutic	therapeutic	ADJ
ijpds-3133	35	7	drugs	drug	NOUN
ijpds-3133	35	8	over	over	ADP
ijpds-3133	35	9	a	a	DET
ijpds-3133	35	10	prolonged	prolonged	ADJ
ijpds-3133	35	11	duration	duration	NOUN
ijpds-3133	35	12	ocular	ocular	ADJ
ijpds-3133	35	13	inserts	insert	NOUN
ijpds-3133	35	14	are	be	AUX
ijpds-3133	35	15	sterile	sterile	ADJ
ijpds-3133	35	16	drugimpregnated	drugimpregnate	VERB
ijpds-3133	35	17	microdevices	microdevice	NOUN
ijpds-3133	35	18	placed	place	VERB
ijpds-3133	35	19	in	in	ADP
ijpds-3133	35	20	or	or	CCONJ
ijpds-3133	35	21	around	around	ADP
ijpds-3133	35	22	the	the	DET
ijpds-3133	35	23	eye	eye	NOUN
ijpds-3133	35	24	.	.	PUNCT
ijpds-3133	36	1	based	base	VERB
ijpds-3133	36	2	on	on	ADP
ijpds-3133	36	3	their	their	PRON
ijpds-3133	36	4	physical	physical	ADJ
ijpds-3133	36	5	and	and	CCONJ
ijpds-3133	36	6	chemical	chemical	NOUN
ijpds-3133	36	7	properties	property	NOUN
ijpds-3133	36	8	,	,	PUNCT
ijpds-3133	36	9	the	the	DET
ijpds-3133	36	10	inserts	insert	NOUN
ijpds-3133	36	11	are	be	AUX
ijpds-3133	36	12	classified	classify	VERB
ijpds-3133	36	13	into	into	ADP
ijpds-3133	36	14	insoluble	insoluble	ADJ
ijpds-3133	36	15	,	,	PUNCT
ijpds-3133	36	16	soluble	soluble	ADJ
ijpds-3133	36	17	,	,	PUNCT
ijpds-3133	36	18	or	or	CCONJ
ijpds-3133	36	19	bioerodible	bioerodible	ADJ
ijpds-3133	37	1	[	[	X
ijpds-3133	37	2	9	9	NUM
ijpds-3133	37	3	]	]	PUNCT
ijpds-3133	37	4	.	.	PUNCT
ijpds-3133	38	1	the	the	DET
ijpds-3133	38	2	contact	contact	NOUN
ijpds-3133	38	3	time	time	NOUN
ijpds-3133	38	4	of	of	ADP
ijpds-3133	38	5	the	the	DET
ijpds-3133	38	6	drug	drug	NOUN
ijpds-3133	38	7	to	to	ADP
ijpds-3133	38	8	a	a	DET
ijpds-3133	38	9	few	few	ADJ
ijpds-3133	38	10	days	day	NOUN
ijpds-3133	38	11	increased	increase	VERB
ijpds-3133	38	12	the	the	DET
ijpds-3133	38	13	ocular	ocular	ADJ
ijpds-3133	38	14	surface	surface	NOUN
ijpds-3133	38	15	after	after	ADP
ijpds-3133	38	16	insertion	insertion	NOUN
ijpds-3133	38	17	,	,	PUNCT
ijpds-3133	38	18	thereby	thereby	ADV
ijpds-3133	38	19	increasing	increase	VERB
ijpds-3133	38	20	manifold	manifold	ADJ
ijpds-3133	38	21	bioavailability	bioavailability	NOUN
ijpds-3133	38	22	due	due	ADJ
ijpds-3133	38	23	to	to	PART
ijpds-3133	38	24	reduce	reduce	VERB
ijpds-3133	38	25	washout	washout	NOUN
ijpds-3133	38	26	by	by	ADP
ijpds-3133	38	27	tears	tear	NOUN
ijpds-3133	38	28	.	.	PUNCT
ijpds-3133	39	1	pilocarpine	pilocarpine	PROPN
ijpds-3133	39	2	ocular	ocular	ADJ
ijpds-3133	39	3	insertsin	insertsin	NOUN
ijpds-3133	39	4	1976	1976	NUM
ijpds-3133	39	5	,	,	PUNCT
ijpds-3133	39	6	bensinger	bensinger	NOUN
ijpds-3133	39	7	et	et	PROPN
ijpds-3133	39	8	al	al	PROPN
ijpds-3133	39	9	.	.	PROPN
ijpds-3133	39	10	demonstrated	demonstrate	VERB
ijpds-3133	39	11	the	the	DET
ijpds-3133	39	12	use	use	NOUN
ijpds-3133	39	13	of	of	ADP
ijpds-3133	39	14	a	a	DET
ijpds-3133	39	15	synthetic	synthetic	ADJ
ijpds-3133	39	16	biosoluble	biosoluble	ADJ
ijpds-3133	39	17	matrix	matrix	NOUN
ijpds-3133	39	18	in	in	ADP
ijpds-3133	39	19	the	the	DET
ijpds-3133	39	20	conjunctival	conjunctival	NOUN
ijpds-3133	39	21	cul	cul	PROPN
ijpds-3133	39	22	-	-	ADJ
ijpds-3133	39	23	de	de	NOUN
ijpds-3133	39	24	-	-	NOUN
ijpds-3133	39	25	sac	sac	NOUN
ijpds-3133	39	26	to	to	PART
ijpds-3133	39	27	increase	increase	VERB
ijpds-3133	39	28	the	the	DET
ijpds-3133	39	29	contact	contact	NOUN
ijpds-3133	39	30	time	time	NOUN
ijpds-3133	39	31	of	of	ADP
ijpds-3133	39	32	pilocarpine	pilocarpine	NOUN
ijpds-3133	39	33	with	with	ADP
ijpds-3133	39	34	the	the	DET
ijpds-3133	39	35	corneal	corneal	ADJ
ijpds-3133	39	36	tear	tear	ADJ
ijpds-3133	39	37	film	film	NOUN
ijpds-3133	39	38	for	for	ADP
ijpds-3133	39	39	intraocular	intraocular	ADJ
ijpds-3133	39	40	pressure	pressure	NOUN
ijpds-3133	39	41	(	(	PUNCT
ijpds-3133	39	42	iop	iop	NOUN
ijpds-3133	39	43	)	)	PUNCT
ijpds-3133	39	44	control	control	NOUN
ijpds-3133	39	45	.	.	PUNCT
ijpds-3133	40	1	different	different	ADJ
ijpds-3133	40	2	doses	dose	NOUN
ijpds-3133	40	3	ranging	range	VERB
ijpds-3133	40	4	from	from	ADP
ijpds-3133	40	5	0.5	0.5	NUM
ijpds-3133	40	6	to	to	PART
ijpds-3133	40	7	2	2	NUM
ijpds-3133	40	8	mg	mg	NOUN
ijpds-3133	40	9	,	,	PUNCT
ijpds-3133	40	10	32	32	NUM
ijpds-3133	40	11	h	h	NOUN
ijpds-3133	40	12	post	post	ADJ
ijpds-3133	40	13	-	-	ADJ
ijpds-3133	40	14	insertion	insertion	NOUN
ijpds-3133	40	15	recorded	record	VERB
ijpds-3133	40	16	with	with	ADP
ijpds-3133	40	17	a	a	DET
ijpds-3133	40	18	significant	significant	ADJ
ijpds-3133	40	19	reduction	reduction	NOUN
ijpds-3133	40	20	in	in	ADP
ijpds-3133	40	21	the	the	DET
ijpds-3133	40	22	iop	iop	NOUN
ijpds-3133	40	23	[	[	X
ijpds-3133	40	24	10	10	NUM
ijpds-3133	40	25	]	]	PUNCT
ijpds-3133	40	26	.	.	PUNCT
ijpds-3133	41	1	the	the	DET
ijpds-3133	41	2	iop	iop	PROPN
ijpds-3133	41	3	had	have	VERB
ijpds-3133	41	4	the	the	DET
ijpds-3133	41	5	maximum	maximum	ADJ
ijpds-3133	41	6	lowering	lowering	NOUN
ijpds-3133	41	7	of	of	ADP
ijpds-3133	41	8	6.25	6.25	NUM
ijpds-3133	41	9	±	±	NUM
ijpds-3133	41	10	2.48	2.48	NUM
ijpds-3133	41	11	mmhg	mmhg	NOUN
ijpds-3133	41	12	on	on	ADP
ijpds-3133	41	13	the	the	DET
ijpds-3133	41	14	placement	placement	NOUN
ijpds-3133	41	15	of	of	ADP
ijpds-3133	41	16	0.5	0.5	NUM
ijpds-3133	41	17	mg	mg	PROPN
ijpds-3133	41	18	pilocarpine	pilocarpine	NOUN
ijpds-3133	41	19	inset	inset	NOUN
ijpds-3133	41	20	.	.	PUNCT
ijpds-3133	42	1	while	while	SCONJ
ijpds-3133	42	2	,	,	PUNCT
ijpds-3133	42	3	a	a	DET
ijpds-3133	42	4	higher	high	ADJ
ijpds-3133	42	5	dose	dose	NOUN
ijpds-3133	42	6	of	of	ADP
ijpds-3133	42	7	1.5	1.5	NUM
ijpds-3133	42	8	mg	mg	PROPN
ijpds-3133	42	9	pilocarpine	pilocarpine	NOUN
ijpds-3133	42	10	reduced	reduce	VERB
ijpds-3133	42	11	the	the	DET
ijpds-3133	42	12	iop	iop	NOUN
ijpds-3133	42	13	by	by	ADP
ijpds-3133	42	14	8.14	8.14	NUM
ijpds-3133	42	15	±	±	NUM
ijpds-3133	42	16	0.96	0.96	NUM
ijpds-3133	42	17	,	,	PUNCT
ijpds-3133	42	18	5	5	NUM
ijpds-3133	42	19	h	h	NOUN
ijpds-3133	42	20	post	post	NOUN
ijpds-3133	42	21	-	-	NOUN
ijpds-3133	42	22	placement	placement	NOUN
ijpds-3133	42	23	.	.	PUNCT
ijpds-3133	43	1	a	a	DET
ijpds-3133	43	2	significant	significant	ADJ
ijpds-3133	43	3	reduction	reduction	NOUN
ijpds-3133	43	4	in	in	ADP
ijpds-3133	43	5	the	the	DET
ijpds-3133	43	6	iop	iop	NOUN
ijpds-3133	43	7	was	be	AUX
ijpds-3133	43	8	noted	note	VERB
ijpds-3133	43	9	at	at	ADP
ijpds-3133	43	10	32	32	NUM
ijpds-3133	43	11	hours	hour	NOUN
ijpds-3133	43	12	after	after	ADP
ijpds-3133	43	13	insertion	insertion	NOUN
ijpds-3133	43	14	of	of	ADP
ijpds-3133	43	15	the	the	DET
ijpds-3133	43	16	1	1	NUM
ijpds-3133	43	17	mg	mg	PROPN
ijpds-3133	43	18	pilocarpine	pilocarpine	NOUN
ijpds-3133	43	19	.	.	PUNCT
ijpds-3133	44	1	soluble	soluble	ADJ
ijpds-3133	44	2	ophthalmic	ophthalmic	ADJ
ijpds-3133	44	3	drug	drug	NOUN
ijpds-3133	44	4	insertsas	insertsa	VERB
ijpds-3133	44	5	the	the	DET
ijpds-3133	44	6	soluble	soluble	ADJ
ijpds-3133	44	7	ocular	ocular	ADJ
ijpds-3133	44	8	drug	drug	NOUN
ijpds-3133	44	9	insert	insert	NOUN
ijpds-3133	44	10	(	(	PUNCT
ijpds-3133	44	11	sodi	sodi	NOUN
ijpds-3133	44	12	)	)	PUNCT
ijpds-3133	44	13	is	be	AUX
ijpds-3133	44	14	an	an	DET
ijpds-3133	44	15	oval	oval	NOUN
ijpds-3133	44	16	-	-	PUNCT
ijpds-3133	44	17	shaped	shape	VERB
ijpds-3133	44	18	ocular	ocular	ADJ
ijpds-3133	44	19	insert	insert	NOUN
ijpds-3133	44	20	made	make	VERB
ijpds-3133	44	21	up	up	ADP
ijpds-3133	44	22	of	of	ADP
ijpds-3133	44	23	a	a	DET
ijpds-3133	44	24	copolymer	copolymer	NOUN
ijpds-3133	44	25	of	of	ADP
ijpds-3133	44	26	polyacrylamide	polyacrylamide	NOUN
ijpds-3133	44	27	,	,	PUNCT
ijpds-3133	44	28	ethyl	ethyl	PROPN
ijpds-3133	44	29	acrylate	acrylate	NOUN
ijpds-3133	44	30	,	,	PUNCT
ijpds-3133	44	31	and	and	CCONJ
ijpds-3133	44	32	vinylpyrrolidone	vinylpyrrolidone	NOUN
ijpds-3133	44	33	.	.	PUNCT
ijpds-3133	45	1	maichuk	maichuk	PROPN
ijpds-3133	46	1	[	[	X
ijpds-3133	46	2	11	11	NUM
ijpds-3133	46	3	]	]	PUNCT
ijpds-3133	46	4	first	first	ADV
ijpds-3133	46	5	reported	report	VERB
ijpds-3133	46	6	and	and	CCONJ
ijpds-3133	46	7	used	use	VERB
ijpds-3133	46	8	to	to	PART
ijpds-3133	46	9	administer	administer	VERB
ijpds-3133	46	10	drugs	drug	NOUN
ijpds-3133	46	11	including	include	VERB
ijpds-3133	46	12	pilocarpine	pilocarpine	NOUN
ijpds-3133	46	13	through	through	ADP
ijpds-3133	46	14	the	the	DET
ijpds-3133	46	15	inferior	inferior	ADJ
ijpds-3133	46	16	culde	culde	NOUN
ijpds-3133	46	17	-	-	PUNCT
ijpds-3133	46	18	sac	sac	NOUN
ijpds-3133	46	19	.	.	PUNCT
ijpds-3133	47	1	the	the	DET
ijpds-3133	47	2	drug	drug	NOUN
ijpds-3133	47	3	insert	insert	PROPN
ijpds-3133	47	4	converts	convert	NOUN
ijpds-3133	47	5	into	into	ADP
ijpds-3133	47	6	a	a	DET
ijpds-3133	47	7	viscous	viscous	ADJ
ijpds-3133	47	8	polymer	polymer	NOUN
ijpds-3133	47	9	solution	solution	NOUN
ijpds-3133	47	10	after	after	ADP
ijpds-3133	47	11	10	10	NUM
ijpds-3133	47	12	to	to	PART
ijpds-3133	47	13	15	15	NUM
ijpds-3133	47	14	-	-	PUNCT
ijpds-3133	47	15	sec	sec	PROPN
ijpds-3133	47	16	contact	contact	NOUN
ijpds-3133	47	17	with	with	ADP
ijpds-3133	47	18	the	the	DET
ijpds-3133	47	19	tear	tear	ADJ
ijpds-3133	47	20	film	film	NOUN
ijpds-3133	47	21	followed	follow	VERB
ijpds-3133	47	22	by	by	ADP
ijpds-3133	47	23	conversion	conversion	NOUN
ijpds-3133	47	24	to	to	ADP
ijpds-3133	47	25	a	a	DET
ijpds-3133	47	26	polymer	polymer	NOUN
ijpds-3133	47	27	solution	solution	NOUN
ijpds-3133	47	28	within	within	ADP
ijpds-3133	47	29	60–90	60–90	NUM
ijpds-3133	47	30	min	min	NOUN
ijpds-3133	47	31	of	of	ADP
ijpds-3133	47	32	administration	administration	NOUN
ijpds-3133	47	33	.	.	PUNCT
ijpds-3133	48	1	ocusertocusert	ocusertocusert	PROPN
ijpds-3133	48	2	was	be	AUX
ijpds-3133	48	3	one	one	NUM
ijpds-3133	48	4	of	of	ADP
ijpds-3133	48	5	the	the	DET
ijpds-3133	48	6	earliest	early	ADJ
ijpds-3133	48	7	models	model	NOUN
ijpds-3133	48	8	of	of	ADP
ijpds-3133	48	9	ocular	ocular	ADJ
ijpds-3133	48	10	inserts	insert	NOUN
ijpds-3133	48	11	developed	develop	VERB
ijpds-3133	48	12	by	by	ADP
ijpds-3133	48	13	armaly	armaly	NOUN
ijpds-3133	48	14	and	and	CCONJ
ijpds-3133	48	15	rao	rao	PROPN
ijpds-3133	49	1	[	[	X
ijpds-3133	49	2	12	12	NUM
ijpds-3133	49	3	]	]	PUNCT
ijpds-3133	49	4	,	,	PUNCT
ijpds-3133	49	5	made	make	VERB
ijpds-3133	49	6	commercially	commercially	ADV
ijpds-3133	49	7	available	available	ADJ
ijpds-3133	49	8	by	by	ADP
ijpds-3133	49	9	alza	alza	PROPN
ijpds-3133	49	10	corporation	corporation	PROPN
ijpds-3133	49	11	inc	inc	PROPN
ijpds-3133	49	12	.	.	PROPN
ijpds-3133	49	13	ocusert	ocusert	PROPN
ijpds-3133	49	14	releases	release	VERB
ijpds-3133	49	15	the	the	DET
ijpds-3133	49	16	drug	drug	NOUN
ijpds-3133	49	17	at	at	ADP
ijpds-3133	49	18	a	a	DET
ijpds-3133	49	19	constant	constant	ADJ
ijpds-3133	49	20	rate	rate	NOUN
ijpds-3133	49	21	of	of	ADP
ijpds-3133	49	22	20	20	NUM
ijpds-3133	49	23	or	or	CCONJ
ijpds-3133	49	24	40	40	NUM
ijpds-3133	49	25	μg	μg	PROPN
ijpds-3133	49	26	/	/	SYM
ijpds-3133	49	27	h	h	PROPN
ijpds-3133	49	28	for	for	ADP
ijpds-3133	49	29	an	an	DET
ijpds-3133	49	30	extended	extended	ADJ
ijpds-3133	49	31	period	period	NOUN
ijpds-3133	49	32	of	of	ADP
ijpds-3133	49	33	7	7	NUM
ijpds-3133	49	34	days	day	NOUN
ijpds-3133	49	35	.	.	PUNCT
ijpds-3133	50	1	pilocarpine	pilocarpine	PROPN
ijpds-3133	50	2	was	be	AUX
ijpds-3133	50	3	loaded	load	VERB
ijpds-3133	50	4	in	in	ADP
ijpds-3133	50	5	a	a	DET
ijpds-3133	50	6	polymer	polymer	NOUN
ijpds-3133	50	7	membrane	membrane	NOUN
ijpds-3133	50	8	system	system	NOUN
ijpds-3133	50	9	consisting	consist	VERB
ijpds-3133	50	10	of	of	ADP
ijpds-3133	50	11	an	an	DET
ijpds-3133	50	12	inner	inner	ADJ
ijpds-3133	50	13	layer	layer	NOUN
ijpds-3133	50	14	of	of	ADP
ijpds-3133	50	15	pilocarpine	pilocarpine	NOUN
ijpds-3133	50	16	in	in	ADP
ijpds-3133	50	17	alginate	alginate	NOUN
ijpds-3133	50	18	gel	gel	NOUN
ijpds-3133	50	19	di-(ethylhexyl	di-(ethylhexyl	NOUN
ijpds-3133	50	20	)	)	PUNCT
ijpds-3133	50	21	phthalate	phthalate	NOUN
ijpds-3133	50	22	for	for	ADP
ijpds-3133	50	23	a	a	DET
ijpds-3133	50	24	release	release	NOUN
ijpds-3133	50	25	enhancer	enhancer	NOUN
ijpds-3133	50	26	sandwiched	sandwich	VERB
ijpds-3133	50	27	between	between	ADP
ijpds-3133	50	28	two	two	NUM
ijpds-3133	50	29	outer	outer	ADJ
ijpds-3133	50	30	layers	layer	NOUN
ijpds-3133	50	31	of	of	ADP
ijpds-3133	50	32	ethylene	ethylene	NOUN
ijpds-3133	50	33	-	-	PUNCT
ijpds-3133	50	34	vinyl	vinyl	NOUN
ijpds-3133	50	35	acetate	acetate	NOUN
ijpds-3133	50	36	(	(	PUNCT
ijpds-3133	50	37	eva	eva	PROPN
ijpds-3133	50	38	)	)	PUNCT
ijpds-3133	50	39	designed	design	VERB
ijpds-3133	50	40	to	to	PART
ijpds-3133	50	41	release	release	VERB
ijpds-3133	50	42	the	the	DET
ijpds-3133	50	43	drug	drug	NOUN
ijpds-3133	50	44	at	at	ADP
ijpds-3133	50	45	a	a	DET
ijpds-3133	50	46	predetermined	predetermine	VERB
ijpds-3133	50	47	constant	constant	ADJ
ijpds-3133	50	48	rate	rate	NOUN
ijpds-3133	50	49	.	.	PUNCT
ijpds-3133	51	1	zimmerman	zimmerman	PROPN
ijpds-3133	51	2	et	et	PROPN
ijpds-3133	51	3	al	al	PROPN
ijpds-3133	51	4	.	.	PROPN
ijpds-3133	51	5	studied	study	VERB
ijpds-3133	51	6	pilocarpine	pilocarpine	NOUN
ijpds-3133	51	7	delivery	delivery	NOUN
ijpds-3133	51	8	in	in	ADP
ijpds-3133	51	9	40	40	NUM
ijpds-3133	51	10	patients	patient	NOUN
ijpds-3133	51	11	for	for	ADP
ijpds-3133	51	12	ocusert	ocusert	NOUN
ijpds-3133	51	13	with	with	ADP
ijpds-3133	51	14	a	a	DET
ijpds-3133	51	15	target	target	NOUN
ijpds-3133	51	16	release	release	NOUN
ijpds-3133	51	17	rate	rate	NOUN
ijpds-3133	51	18	of	of	ADP
ijpds-3133	51	19	20	20	NUM
ijpds-3133	51	20	µg	µg	NOUN
ijpds-3133	51	21	/	/	SYM
ijpds-3133	51	22	h.	h.	PROPN
ijpds-3133	51	23	initially	initially	ADV
ijpds-3133	51	24	,	,	PUNCT
ijpds-3133	51	25	the	the	DET
ijpds-3133	51	26	mean	mean	ADJ
ijpds-3133	51	27	iop	iop	PROPN
ijpds-3133	51	28	was	be	AUX
ijpds-3133	51	29	recorded	record	VERB
ijpds-3133	51	30	to	to	PART
ijpds-3133	51	31	be	be	AUX
ijpds-3133	51	32	25.6	25.6	NUM
ijpds-3133	51	33	±	±	NUM
ijpds-3133	51	34	5.6	5.6	NUM
ijpds-3133	51	35	mmhg	mmhg	NOUN
ijpds-3133	51	36	.	.	PUNCT
ijpds-3133	52	1	iop	iop	PROPN
ijpds-3133	52	2	was	be	AUX
ijpds-3133	52	3	reduced	reduce	VERB
ijpds-3133	52	4	to	to	ADP
ijpds-3133	52	5	19.9	19.9	NUM
ijpds-3133	52	6	±	±	NUM
ijpds-3133	52	7	3.9	3.9	NUM
ijpds-3133	52	8	mmhg	mmhg	NOUN
ijpds-3133	52	9	by	by	ADP
ijpds-3133	52	10	using	use	VERB
ijpds-3133	52	11	pilocarpine	pilocarpine	NOUN
ijpds-3133	52	12	-	-	PUNCT
ijpds-3133	52	13	loaded	load	VERB
ijpds-3133	52	14	ocusert	ocusert	NOUN
ijpds-3133	52	15	.	.	PUNCT
ijpds-3133	53	1	the	the	DET
ijpds-3133	53	2	study	study	NOUN
ijpds-3133	53	3	reported	report	VERB
ijpds-3133	53	4	that	that	SCONJ
ijpds-3133	53	5	the	the	DET
ijpds-3133	53	6	patients	patient	NOUN
ijpds-3133	53	7	do	do	AUX
ijpds-3133	53	8	not	not	PART
ijpds-3133	53	9	prefer	prefer	VERB
ijpds-3133	53	10	the	the	DET
ijpds-3133	53	11	pilocarpine	pilocarpine	NOUN
ijpds-3133	53	12	drops	drop	VERB
ijpds-3133	53	13	over	over	ADP
ijpds-3133	53	14	the	the	DET
ijpds-3133	53	15	ocusert	ocusert	ADJ
ijpds-3133	53	16	system	system	NOUN
ijpds-3133	53	17	.	.	PUNCT
ijpds-3133	54	1	no	no	DET
ijpds-3133	54	2	side	side	NOUN
ijpds-3133	54	3	effects	effect	NOUN
ijpds-3133	54	4	from	from	ADP
ijpds-3133	54	5	the	the	DET
ijpds-3133	54	6	ocusert	ocusert	NOUN
ijpds-3133	54	7	were	be	AUX
ijpds-3133	54	8	noted	note	VERB
ijpds-3133	54	9	[	[	X
ijpds-3133	54	10	13	13	NUM
ijpds-3133	54	11	]	]	PUNCT
ijpds-3133	54	12	.	.	PUNCT
ijpds-3133	55	1	pavan	pavan	PROPN
ijpds-3133	55	2	-	-	PUNCT
ijpds-3133	55	3	langston	langston	PROPN
ijpds-3133	55	4	et	et	PROPN
ijpds-3133	55	5	al	al	PROPN
ijpds-3133	55	6	.	.	PROPN
ijpds-3133	55	7	studied	study	VERB
ijpds-3133	55	8	29	29	NUM
ijpds-3133	55	9	patients	patient	NOUN
ijpds-3133	55	10	who	who	PRON
ijpds-3133	55	11	showed	show	VERB
ijpds-3133	55	12	that	that	DET
ijpds-3133	55	13	pilocarpine	pilocarpine	NOUN
ijpds-3133	55	14	-	-	PUNCT
ijpds-3133	55	15	loaded	load	VERB
ijpds-3133	55	16	ocuserts	ocusert	NOUN
ijpds-3133	55	17	releasing	release	VERB
ijpds-3133	55	18	either	either	CCONJ
ijpds-3133	55	19	20	20	NUM
ijpds-3133	55	20	or	or	CCONJ
ijpds-3133	55	21	40	40	NUM
ijpds-3133	55	22	μg	μg	PROPN
ijpds-3133	55	23	/	/	SYM
ijpds-3133	55	24	h	h	NOUN
ijpds-3133	55	25	of	of	ADP
ijpds-3133	55	26	pilocarpine	pilocarpine	PROPN
ijpds-3133	55	27	a	a	DET
ijpds-3133	55	28	satisfactory	satisfactory	ADJ
ijpds-3133	55	29	control	control	NOUN
ijpds-3133	55	30	of	of	ADP
ijpds-3133	55	31	the	the	DET
ijpds-3133	55	32	iop	iop	NOUN
ijpds-3133	55	33	.	.	PUNCT
ijpds-3133	56	1	the	the	DET
ijpds-3133	56	2	ocuserts	ocusert	NOUN
ijpds-3133	56	3	side	side	NOUN
ijpds-3133	56	4	effects	effect	NOUN
ijpds-3133	56	5	were	be	AUX
ijpds-3133	56	6	minimal	minimal	ADJ
ijpds-3133	56	7	or	or	CCONJ
ijpds-3133	56	8	absent	absent	ADJ
ijpds-3133	56	9	[	[	X
ijpds-3133	56	10	14	14	NUM
ijpds-3133	56	11	]	]	PUNCT
ijpds-3133	56	12	.	.	PUNCT
ijpds-3133	57	1	ocusert	ocusert	PROPN
ijpds-3133	57	2	did	do	AUX
ijpds-3133	57	3	not	not	PART
ijpds-3133	57	4	become	become	VERB
ijpds-3133	57	5	a	a	DET
ijpds-3133	57	6	widely	widely	ADV
ijpds-3133	57	7	accepted	accept	VERB
ijpds-3133	57	8	method	method	NOUN
ijpds-3133	57	9	of	of	ADP
ijpds-3133	57	10	drug	drug	NOUN
ijpds-3133	57	11	delivery	delivery	NOUN
ijpds-3133	57	12	,	,	PUNCT
ijpds-3133	57	13	although	although	SCONJ
ijpds-3133	57	14	the	the	DET
ijpds-3133	57	15	clinical	clinical	ADJ
ijpds-3133	57	16	studies	study	NOUN
ijpds-3133	57	17	showed	show	VERB
ijpds-3133	57	18	positive	positive	ADJ
ijpds-3133	57	19	outcomes	outcome	NOUN
ijpds-3133	57	20	.	.	PUNCT
ijpds-3133	58	1	this	this	PRON
ijpds-3133	58	2	is	be	AUX
ijpds-3133	58	3	because	because	SCONJ
ijpds-3133	58	4	of	of	ADP
ijpds-3133	58	5	the	the	DET
ijpds-3133	58	6	difficulty	difficulty	NOUN
ijpds-3133	58	7	of	of	ADP
ijpds-3133	58	8	device	device	NOUN
ijpds-3133	58	9	insertion	insertion	NOUN
ijpds-3133	58	10	,	,	PUNCT
ijpds-3133	58	11	failure	failure	NOUN
ijpds-3133	58	12	in	in	ADP
ijpds-3133	58	13	satisfactorily	satisfactorily	ADV
ijpds-3133	58	14	controlling	control	VERB
ijpds-3133	58	15	iop	iop	NOUN
ijpds-3133	58	16	in	in	ADP
ijpds-3133	58	17	many	many	ADJ
ijpds-3133	58	18	patients	patient	NOUN
ijpds-3133	58	19	,	,	PUNCT
ijpds-3133	58	20	ejection	ejection	NOUN
ijpds-3133	58	21	of	of	ADP
ijpds-3133	58	22	the	the	DET
ijpds-3133	58	23	device	device	NOUN
ijpds-3133	58	24	from	from	ADP
ijpds-3133	58	25	the	the	DET
ijpds-3133	58	26	eye	eye	NOUN
ijpds-3133	58	27	,	,	PUNCT
ijpds-3133	58	28	irritation	irritation	NOUN
ijpds-3133	58	29	during	during	ADP
ijpds-3133	58	30	insertion	insertion	NOUN
ijpds-3133	58	31	,	,	PUNCT
ijpds-3133	58	32	and	and	CCONJ
ijpds-3133	58	33	the	the	DET
ijpds-3133	58	34	difficulty	difficulty	NOUN
ijpds-3133	58	35	of	of	ADP
ijpds-3133	58	36	device	device	NOUN
ijpds-3133	58	37	insertion	insertion	NOUN
ijpds-3133	58	38	[	[	X
ijpds-3133	58	39	15	15	NUM
ijpds-3133	58	40	]	]	PUNCT
ijpds-3133	58	41	.	.	PUNCT
ijpds-3133	59	1	poly	poly	ADJ
ijpds-3133	59	2	(	(	PUNCT
ijpds-3133	59	3	vinyl	vinyl	NOUN
ijpds-3133	59	4	methyl	methyl	NOUN
ijpds-3133	59	5	ether	ether	NOUN
ijpds-3133	59	6	-	-	PUNCT
ijpds-3133	59	7	maleic	maleic	VERB
ijpds-3133	59	8	anhydride	anhydride	NOUN
ijpds-3133	59	9	)	)	PUNCT
ijpds-3133	59	10	anhydride	anhydride	NOUN
ijpds-3133	59	11	(	(	PUNCT
ijpds-3133	59	12	pvmma	pvmma	NOUN
ijpds-3133	59	13	)	)	PUNCT
ijpds-3133	59	14	ocular	ocular	ADJ
ijpds-3133	59	15	insertspvmma	insertspvmma	NOUN
ijpds-3133	59	16	and	and	CCONJ
ijpds-3133	59	17	its	its	PRON
ijpds-3133	59	18	alkyl	alkyl	ADJ
ijpds-3133	59	19	monoesters	monoester	NOUN
ijpds-3133	59	20	are	be	AUX
ijpds-3133	59	21	bioerodible	bioerodible	ADJ
ijpds-3133	59	22	polymers	polymer	NOUN
ijpds-3133	59	23	used	use	VERB
ijpds-3133	59	24	for	for	ADP
ijpds-3133	59	25	controlled	control	VERB
ijpds-3133	59	26	timolol	timolol	NOUN
ijpds-3133	59	27	release	release	NOUN
ijpds-3133	59	28	in	in	ADP
ijpds-3133	59	29	animals	animal	NOUN
ijpds-3133	59	30	.	.	PUNCT
ijpds-3133	60	1	the	the	DET
ijpds-3133	60	2	systemic	systemic	ADJ
ijpds-3133	60	3	effect	effect	NOUN
ijpds-3133	60	4	of	of	ADP
ijpds-3133	60	5	timolol	timolol	NOUN
ijpds-3133	60	6	is	be	AUX
ijpds-3133	60	7	reduced	reduce	VERB
ijpds-3133	60	8	by	by	ADP
ijpds-3133	60	9	the	the	DET
ijpds-3133	60	10	polymer	polymer	NOUN
ijpds-3133	60	11	-	-	PUNCT
ijpds-3133	60	12	assisted	assist	VERB
ijpds-3133	60	13	drug	drug	NOUN
ijpds-3133	60	14	release	release	NOUN
ijpds-3133	60	15	.	.	PUNCT
ijpds-3133	61	1	finne	finne	VERB
ijpds-3133	61	2	et	et	NOUN
ijpds-3133	61	3	al	al	PROPN
ijpds-3133	61	4	.	.	PUNCT
ijpds-3133	62	1	[	[	X
ijpds-3133	62	2	16	16	NUM
ijpds-3133	62	3	]	]	PUNCT
ijpds-3133	62	4	found	find	VERB
ijpds-3133	62	5	a	a	DET
ijpds-3133	62	6	lower	low	ADJ
ijpds-3133	62	7	steady	steady	ADJ
ijpds-3133	62	8	-	-	PUNCT
ijpds-3133	62	9	state	state	NOUN
ijpds-3133	62	10	concentration	concentration	NOUN
ijpds-3133	62	11	(	(	PUNCT
ijpds-3133	62	12	1.0	1.0	NUM
ijpds-3133	62	13	±	±	NUM
ijpds-3133	62	14	0.1	0.1	NUM
ijpds-3133	62	15	ng	ng	PROPN
ijpds-3133	62	16	/	/	SYM
ijpds-3133	62	17	ml	ml	NOUN
ijpds-3133	62	18	)	)	PUNCT
ijpds-3133	62	19	in	in	ADP
ijpds-3133	62	20	plasma	plasma	NOUN
ijpds-3133	62	21	three	three	NUM
ijpds-3133	62	22	hours	hour	NOUN
ijpds-3133	62	23	after	after	ADP
ijpds-3133	62	24	administration	administration	NOUN
ijpds-3133	62	25	and	and	CCONJ
ijpds-3133	62	26	a	a	DET
ijpds-3133	62	27	peak	peak	NOUN
ijpds-3133	62	28	concentration	concentration	NOUN
ijpds-3133	62	29	of	of	ADP
ijpds-3133	62	30	timolol	timolol	NOUN
ijpds-3133	62	31	in	in	ADP
ijpds-3133	62	32	tear	tear	ADJ
ijpds-3133	62	33	fluid	fluid	NOUN
ijpds-3133	62	34	(	(	PUNCT
ijpds-3133	62	35	64	64	NUM
ijpds-3133	62	36	±	±	NUM
ijpds-3133	62	37	9	9	NUM
ijpds-3133	62	38	μg	μg	NOUN
ijpds-3133	62	39	/	/	SYM
ijpds-3133	62	40	ml	ml	NOUN
ijpds-3133	62	41	)	)	PUNCT
ijpds-3133	62	42	.	.	PUNCT
ijpds-3133	63	1	they	they	PRON
ijpds-3133	63	2	also	also	ADV
ijpds-3133	63	3	reported	report	VERB
ijpds-3133	63	4	a	a	DET
ijpds-3133	63	5	1.6	1.6	NUM
ijpds-3133	63	6	-	-	ADJ
ijpds-3133	63	7	fold	fold	ADJ
ijpds-3133	63	8	increase	increase	NOUN
ijpds-3133	63	9	in	in	ADP
ijpds-3133	63	10	timolol	timolol	NOUN
ijpds-3133	63	11	concentration	concentration	NOUN
ijpds-3133	63	12	in	in	ADP
ijpds-3133	63	13	tears	tear	NOUN
ijpds-3133	63	14	(	(	PUNCT
ijpds-3133	63	15	104	104	NUM
ijpds-3133	63	16	±	±	NUM
ijpds-3133	63	17	8	8	NUM
ijpds-3133	63	18	μg	μg	NOUN
ijpds-3133	63	19	/	/	SYM
ijpds-3133	63	20	ml	ml	NOUN
ijpds-3133	63	21	)	)	PUNCT
ijpds-3133	63	22	on	on	ADP
ijpds-3133	63	23	the	the	DET
ijpds-3133	63	24	addition	addition	NOUN
ijpds-3133	63	25	of	of	ADP
ijpds-3133	63	26	disodium	disodium	NOUN
ijpds-3133	63	27	phosphate	phosphate	NOUN
ijpds-3133	63	28	as	as	ADP
ijpds-3133	63	29	a	a	DET
ijpds-3133	63	30	buffer	buffer	NOUN
ijpds-3133	63	31	.	.	PUNCT
ijpds-3133	64	1	collagen	collagen	NOUN
ijpds-3133	64	2	shieldcollagen	shieldcollagen	NOUN
ijpds-3133	64	3	shields	shield	NOUN
ijpds-3133	64	4	as	as	ADP
ijpds-3133	64	5	postoperative	postoperative	ADJ
ijpds-3133	64	6	corneal	corneal	ADJ
ijpds-3133	64	7	bandages	bandage	NOUN
ijpds-3133	64	8	developed	develop	VERB
ijpds-3133	64	9	by	by	ADP
ijpds-3133	64	10	dr	dr	PROPN
ijpds-3133	64	11	.	.	PROPN
ijpds-3133	64	12	svyatoslav	svyatoslav	PROPN
ijpds-3133	64	13	fyodorov	fyodorov	PUNCT
ijpds-3133	65	1	[	[	X
ijpds-3133	65	2	17	17	NUM
ijpds-3133	65	3	]	]	PUNCT
ijpds-3133	65	4	.	.	PUNCT
ijpds-3133	66	1	bloomfield	bloomfield	PROPN
ijpds-3133	66	2	et	et	PROPN
ijpds-3133	67	1	al	al	PROPN
ijpds-3133	67	2	.	.	PROPN
ijpds-3133	67	3	developed	develop	VERB
ijpds-3133	67	4	the	the	DET
ijpds-3133	67	5	drug	drug	NOUN
ijpds-3133	67	6	delivery	delivery	NOUN
ijpds-3133	67	7	model	model	NOUN
ijpds-3133	67	8	for	for	ADP
ijpds-3133	67	9	the	the	DET
ijpds-3133	67	10	collagen	collagen	NOUN
ijpds-3133	67	11	shields	shield	NOUN
ijpds-3133	67	12	.	.	PUNCT
ijpds-3133	68	1	a	a	DET
ijpds-3133	68	2	higher	high	ADJ
ijpds-3133	68	3	level	level	NOUN
ijpds-3133	68	4	of	of	ADP
ijpds-3133	68	5	gentamicin	gentamicin	NOUN
ijpds-3133	68	6	in	in	ADP
ijpds-3133	68	7	the	the	DET
ijpds-3133	68	8	tear	tear	NOUN
ijpds-3133	68	9	film	film	NOUN
ijpds-3133	68	10	,	,	PUNCT
ijpds-3133	68	11	tissues	tissue	NOUN
ijpds-3133	68	12	in	in	ADP
ijpds-3133	68	13	rabbit	rabbit	NOUN
ijpds-3133	68	14	eyes	eye	NOUN
ijpds-3133	68	15	using	use	VERB
ijpds-3133	68	16	wafer	wafer	NOUN
ijpds-3133	68	17	-	-	PUNCT
ijpds-3133	68	18	shaped	shape	VERB
ijpds-3133	68	19	collagen	collagen	NOUN
ijpds-3133	68	20	inserts	insert	NOUN
ijpds-3133	68	21	impregnated	impregnate	VERB
ijpds-3133	68	22	with	with	ADP
ijpds-3133	68	23	gentamicin	gentamicin	NOUN
ijpds-3133	68	24	as	as	ADP
ijpds-3133	68	25	compared	compare	VERB
ijpds-3133	68	26	with	with	ADP
ijpds-3133	68	27	ointment	ointment	NOUN
ijpds-3133	68	28	,	,	PUNCT
ijpds-3133	68	29	eye	eye	NOUN
ijpds-3133	68	30	drops	drop	NOUN
ijpds-3133	68	31	,	,	PUNCT
ijpds-3133	68	32	and	and	CCONJ
ijpds-3133	68	33	subconjunctival	subconjunctival	ADJ
ijpds-3133	68	34	injection	injection	NOUN
ijpds-3133	68	35	demostrated	demostrate	VERB
ijpds-3133	68	36	by	by	ADP
ijpds-3133	68	37	bloomfield	bloomfield	PROPN
ijpds-3133	68	38	et	et	PROPN
ijpds-3133	68	39	al	al	PROPN
ijpds-3133	68	40	.	.	PUNCT
ijpds-3133	69	1	[	[	X
ijpds-3133	69	2	18	18	NUM
ijpds-3133	69	3	]	]	PUNCT
ijpds-3133	69	4	.	.	PUNCT
ijpds-3133	70	1	collagen	collagen	NOUN
ijpds-3133	70	2	shields	shield	NOUN
ijpds-3133	70	3	,	,	PUNCT
ijpds-3133	70	4	were	be	AUX
ijpds-3133	70	5	loaded	load	VERB
ijpds-3133	70	6	with	with	ADP
ijpds-3133	70	7	hydrophilic	hydrophilic	ADJ
ijpds-3133	70	8	drugs	drug	NOUN
ijpds-3133	70	9	in	in	ADP
ijpds-3133	70	10	the	the	DET
ijpds-3133	70	11	collagen	collagen	NOUN
ijpds-3133	70	12	matrix	matrix	NOUN
ijpds-3133	70	13	by	by	ADP
ijpds-3133	70	14	soaking	soak	VERB
ijpds-3133	70	15	a	a	DET
ijpds-3133	70	16	dry	dry	ADJ
ijpds-3133	70	17	shield	shield	NOUN
ijpds-3133	70	18	in	in	ADP
ijpds-3133	70	19	the	the	DET
ijpds-3133	70	20	aqueous	aqueous	ADJ
ijpds-3133	70	21	solution	solution	NOUN
ijpds-3133	70	22	of	of	ADP
ijpds-3133	70	23	the	the	DET
ijpds-3133	70	24	drug	drug	NOUN
ijpds-3133	70	25	.	.	PUNCT
ijpds-3133	71	1	the	the	DET
ijpds-3133	71	2	water	water	NOUN
ijpds-3133	71	3	-	-	PUNCT
ijpds-3133	71	4	insoluble	insoluble	ADJ
ijpds-3133	71	5	drugs	drug	NOUN
ijpds-3133	71	6	are	be	AUX
ijpds-3133	71	7	directly	directly	ADV
ijpds-3133	71	8	added	add	VERB
ijpds-3133	71	9	to	to	ADP
ijpds-3133	71	10	the	the	DET
ijpds-3133	71	11	shield	shield	NOUN
ijpds-3133	71	12	during	during	ADP
ijpds-3133	71	13	the	the	DET
ijpds-3133	71	14	manufacturing	manufacturing	NOUN
ijpds-3133	71	15	process	process	NOUN
ijpds-3133	71	16	.	.	PUNCT
ijpds-3133	72	1	agban	agban	NOUN
ijpds-3133	72	2	et	et	PROPN
ijpds-3133	72	3	al	al	PROPN
ijpds-3133	72	4	.	.	PUNCT
ijpds-3133	73	1	[	[	X
ijpds-3133	73	2	19	19	NUM
ijpds-3133	73	3	]	]	PUNCT
ijpds-3133	73	4	developed	develop	VERB
ijpds-3133	73	5	cross	cross	ADJ
ijpds-3133	73	6	-	-	ADJ
ijpds-3133	73	7	linked	link	VERB
ijpds-3133	73	8	collagen	collagen	NOUN
ijpds-3133	73	9	shields	shield	NOUN
ijpds-3133	73	10	consisting	consist	VERB
ijpds-3133	73	11	of	of	ADP
ijpds-3133	73	12	nanoparticles	nanoparticle	NOUN
ijpds-3133	73	13	of	of	ADP
ijpds-3133	73	14	titanium	titanium	NOUN
ijpds-3133	73	15	dioxide	dioxide	NOUN
ijpds-3133	73	16	(	(	PUNCT
ijpds-3133	73	17	tio2	tio2	NOUN
ijpds-3133	73	18	)	)	PUNCT
ijpds-3133	73	19	,	,	PUNCT
ijpds-3133	73	20	zinc	zinc	NOUN
ijpds-3133	73	21	oxide	oxide	NOUN
ijpds-3133	73	22	(	(	PUNCT
ijpds-3133	73	23	zno	zno	NOUN
ijpds-3133	73	24	)	)	PUNCT
ijpds-3133	73	25	,	,	PUNCT
ijpds-3133	73	26	polyvinyl	polyvinyl	NOUN
ijpds-3133	73	27	pyrrolidone	pyrrolidone	NOUN
ijpds-3133	73	28	(	(	PUNCT
ijpds-3133	73	29	pvp	pvp	NOUN
ijpds-3133	73	30	)	)	PUNCT
ijpds-3133	73	31	,	,	PUNCT
ijpds-3133	73	32	and	and	CCONJ
ijpds-3133	73	33	capped	capped	ADJ
ijpds-3133	73	34	zinc	zinc	NOUN
ijpds-3133	73	35	oxide	oxide	NOUN
ijpds-3133	73	36	(	(	PUNCT
ijpds-3133	73	37	zno	zno	NOUN
ijpds-3133	73	38	/	/	SYM
ijpds-3133	73	39	pvp	pvp	PROPN
ijpds-3133	73	40	)	)	PUNCT
ijpds-3133	73	41	for	for	ADP
ijpds-3133	73	42	controlled	control	VERB
ijpds-3133	73	43	delivery	delivery	NOUN
ijpds-3133	73	44	of	of	ADP
ijpds-3133	73	45	pilocarpine	pilocarpine	NOUN
ijpds-3133	73	46	hydrochloride	hydrochloride	NOUN
ijpds-3133	73	47	in	in	ADP
ijpds-3133	73	48	glaucoma	glaucoma	NOUN
ijpds-3133	73	49	patients	patient	NOUN
ijpds-3133	73	50	over	over	ADP
ijpds-3133	73	51	a	a	DET
ijpds-3133	73	52	prolonged	prolonged	ADJ
ijpds-3133	73	53	duration	duration	NOUN
ijpds-3133	73	54	that	that	SCONJ
ijpds-3133	73	55	undergoing	undergo	VERB
ijpds-3133	73	56	animal	animal	NOUN
ijpds-3133	73	57	trials	trial	NOUN
ijpds-3133	73	58	.	.	PUNCT
ijpds-3133	74	1	the	the	DET
ijpds-3133	74	2	results	result	NOUN
ijpds-3133	74	3	from	from	ADP
ijpds-3133	74	4	the	the	DET
ijpds-3133	74	5	group	group	NOUN
ijpds-3133	74	6	show	show	VERB
ijpds-3133	74	7	a	a	DET
ijpds-3133	74	8	sustained	sustained	ADJ
ijpds-3133	74	9	release	release	NOUN
ijpds-3133	74	10	of	of	ADP
ijpds-3133	74	11	pilocarpine	pilocarpine	NOUN
ijpds-3133	74	12	hydrochloride	hydrochloride	NOUN
ijpds-3133	74	13	when	when	SCONJ
ijpds-3133	74	14	crosslinked	crosslinke	VERB
ijpds-3133	74	15	with	with	ADP
ijpds-3133	74	16	zno	zno	NOUN
ijpds-3133	74	17	/	/	SYM
ijpds-3133	74	18	pvp	pvp	NOUN
ijpds-3133	74	19	nanoparticles	nanoparticle	NOUN
ijpds-3133	74	20	for	for	ADP
ijpds-3133	74	21	14	14	NUM
ijpds-3133	74	22	days	day	NOUN
ijpds-3133	74	23	.	.	PUNCT
ijpds-3133	75	1	ocufit	ocufit	NOUN
ijpds-3133	75	2	srdeveloped	srdevelope	VERB
ijpds-3133	75	3	by	by	ADP
ijpds-3133	75	4	escalon	escalon	NOUN
ijpds-3133	75	5	ophthalmics	ophthalmics	PROPN
ijpds-3133	75	6	inc	inc	PROPN
ijpds-3133	75	7	.	.	PROPN
ijpds-3133	75	8	is	be	AUX
ijpds-3133	75	9	a	a	DET
ijpds-3133	75	10	flexible	flexible	ADJ
ijpds-3133	75	11	rod	rod	NOUN
ijpds-3133	75	12	-	-	PUNCT
ijpds-3133	75	13	shaped	shape	VERB
ijpds-3133	75	14	silicon	silicon	NOUN
ijpds-3133	75	15	elastomer	elastomer	NOUN
ijpds-3133	75	16	device	device	NOUN
ijpds-3133	75	17	designed	design	VERB
ijpds-3133	75	18	for	for	ADP
ijpds-3133	75	19	rai	rai	PROPN
ijpds-3133	75	20	et	et	PROPN
ijpds-3133	75	21	al	al	PROPN
ijpds-3133	75	22	mindful	mindful	ADJ
ijpds-3133	75	23	-	-	PUNCT
ijpds-3133	75	24	based	base	VERB
ijpds-3133	75	25	stress	stress	NOUN
ijpds-3133	75	26	reduction	reduction	NOUN
ijpds-3133	75	27	impact	impact	NOUN
ijpds-3133	75	28	vol	vol	NOUN
ijpds-3133	75	29	1	1	NUM
ijpds-3133	75	30	|	|	NOUN
ijpds-3133	75	31	issue	issue	NOUN
ijpds-3133	75	32	2	2	NUM
ijpds-3133	76	1	|	|	ADV
ijpds-3133	76	2	jul	jul	PROPN
ijpds-3133	76	3	–	–	PUNCT
ijpds-3133	76	4	sep	sep	PROPN
ijpds-3133	76	5	2022	2022	NUM
ijpds-3133	76	6	indian	indian	PROPN
ijpds-3133	76	7	j	j	PROPN
ijpds-3133	76	8	pharm	pharm	PROPN
ijpds-3133	76	9	drug	drug	PROPN
ijpds-3133	76	10	studies	study	NOUN
ijpds-3133	76	11	|	|	ADV
ijpds-3133	76	12	40	40	NUM
ijpds-3133	76	13	retention	retention	NOUN
ijpds-3133	76	14	in	in	ADP
ijpds-3133	76	15	the	the	DET
ijpds-3133	76	16	conjunctival	conjunctival	NOUN
ijpds-3133	76	17	fornix	fornix	NOUN
ijpds-3133	76	18	for	for	ADP
ijpds-3133	76	19	controlled	control	VERB
ijpds-3133	76	20	release	release	NOUN
ijpds-3133	76	21	of	of	ADP
ijpds-3133	76	22	drugs	drug	NOUN
ijpds-3133	76	23	over	over	ADP
ijpds-3133	76	24	long	long	ADJ
ijpds-3133	76	25	periods	period	NOUN
ijpds-3133	76	26	.	.	PUNCT
ijpds-3133	77	1	the	the	DET
ijpds-3133	77	2	different	different	ADJ
ijpds-3133	77	3	models	model	NOUN
ijpds-3133	77	4	are	be	AUX
ijpds-3133	77	5	a	a	DET
ijpds-3133	77	6	maximum	maximum	NOUN
ijpds-3133	77	7	of	of	ADP
ijpds-3133	77	8	1.9	1.9	NUM
ijpds-3133	77	9	mm	mm	NOUN
ijpds-3133	77	10	in	in	ADP
ijpds-3133	77	11	diameter	diameter	NOUN
ijpds-3133	77	12	and	and	CCONJ
ijpds-3133	77	13	range	range	VERB
ijpds-3133	77	14	between	between	ADP
ijpds-3133	77	15	25	25	NUM
ijpds-3133	77	16	and	and	CCONJ
ijpds-3133	77	17	30	30	NUM
ijpds-3133	77	18	mm	mm	NOUN
ijpds-3133	77	19	in	in	ADP
ijpds-3133	77	20	length	length	NOUN
ijpds-3133	77	21	.	.	PUNCT
ijpds-3133	78	1	katz	katz	PROPN
ijpds-3133	78	2	and	and	CCONJ
ijpds-3133	78	3	blackman	blackman	PROPN
ijpds-3133	79	1	[	[	X
ijpds-3133	79	2	20	20	NUM
ijpds-3133	79	3	]	]	PUNCT
ijpds-3133	79	4	later	later	ADV
ijpds-3133	79	5	reported	report	VERB
ijpds-3133	79	6	that	that	SCONJ
ijpds-3133	79	7	expulsion	expulsion	NOUN
ijpds-3133	79	8	of	of	ADP
ijpds-3133	79	9	rod	rod	NOUN
ijpds-3133	79	10	-	-	PUNCT
ijpds-3133	79	11	shaped	shape	VERB
ijpds-3133	79	12	devices	device	NOUN
ijpds-3133	79	13	was	be	AUX
ijpds-3133	79	14	significantly	significantly	ADV
ijpds-3133	79	15	less	less	ADV
ijpds-3133	79	16	frequent	frequent	ADJ
ijpds-3133	79	17	than	than	ADP
ijpds-3133	79	18	that	that	PRON
ijpds-3133	79	19	of	of	ADP
ijpds-3133	79	20	oval	oval	NOUN
ijpds-3133	79	21	,	,	PUNCT
ijpds-3133	79	22	flat	flat	ADJ
ijpds-3133	79	23	inserts	insert	NOUN
ijpds-3133	79	24	.	.	PUNCT
ijpds-3133	80	1	the	the	DET
ijpds-3133	80	2	insoluble	insoluble	ADJ
ijpds-3133	80	3	ocufit	ocufit	NOUN
ijpds-3133	80	4	had	have	VERB
ijpds-3133	80	5	favorable	favorable	ADJ
ijpds-3133	80	6	properties	property	NOUN
ijpds-3133	80	7	of	of	ADP
ijpds-3133	80	8	both	both	DET
ijpds-3133	80	9	long	long	ADJ
ijpds-3133	80	10	retention	retention	NOUN
ijpds-3133	80	11	and	and	CCONJ
ijpds-3133	80	12	sustained	sustained	ADJ
ijpds-3133	80	13	drug	drug	NOUN
ijpds-3133	80	14	release	release	NOUN
ijpds-3133	80	15	.	.	PUNCT
ijpds-3133	81	1	in	in	ADP
ijpds-3133	81	2	70	70	NUM
ijpds-3133	81	3	%	%	NOUN
ijpds-3133	81	4	of	of	ADP
ijpds-3133	81	5	the	the	DET
ijpds-3133	81	6	cases	case	NOUN
ijpds-3133	81	7	,	,	PUNCT
ijpds-3133	81	8	the	the	DET
ijpds-3133	81	9	upper	upper	ADJ
ijpds-3133	81	10	fornix	fornix	NOUN
ijpds-3133	81	11	placebo	placebo	NOUN
ijpds-3133	81	12	device	device	NOUN
ijpds-3133	81	13	was	be	AUX
ijpds-3133	81	14	retained	retain	VERB
ijpds-3133	81	15	for	for	ADP
ijpds-3133	81	16	two	two	NUM
ijpds-3133	81	17	weeks	week	NOUN
ijpds-3133	81	18	or	or	CCONJ
ijpds-3133	81	19	more	more	ADJ
ijpds-3133	81	20	.	.	PUNCT
ijpds-3133	82	1	minidiscbawa	minidiscbawa	PROPN
ijpds-3133	82	2	et	et	PROPN
ijpds-3133	82	3	al	al	PROPN
ijpds-3133	82	4	.	.	PUNCT
ijpds-3133	83	1	[	[	X
ijpds-3133	83	2	21	21	NUM
ijpds-3133	83	3	]	]	PUNCT
ijpds-3133	83	4	developed	develop	VERB
ijpds-3133	83	5	the	the	DET
ijpds-3133	83	6	minidisc	minidisc	NOUN
ijpds-3133	83	7	or	or	CCONJ
ijpds-3133	83	8	ocular	ocular	ADJ
ijpds-3133	83	9	therapeutic	therapeutic	ADJ
ijpds-3133	83	10	system	system	NOUN
ijpds-3133	83	11	(	(	PUNCT
ijpds-3133	83	12	ots	ots	PROPN
ijpds-3133	83	13	)	)	PUNCT
ijpds-3133	83	14	the	the	DET
ijpds-3133	83	15	miniature	miniature	ADJ
ijpds-3133	83	16	contact	contact	NOUN
ijpds-3133	83	17	lens	lens	NOUN
ijpds-3133	83	18	with	with	ADP
ijpds-3133	83	19	a	a	DET
ijpds-3133	83	20	diameter	diameter	NOUN
ijpds-3133	83	21	of	of	ADP
ijpds-3133	83	22	4–5	4–5	PROPN
ijpds-3133	83	23	mm	mm	PROPN
ijpds-3133	83	24	with	with	ADP
ijpds-3133	83	25	a	a	DET
ijpds-3133	83	26	convex	convex	NOUN
ijpds-3133	83	27	and	and	CCONJ
ijpds-3133	83	28	a	a	DET
ijpds-3133	83	29	concave	concave	NOUN
ijpds-3133	83	30	face	face	NOUN
ijpds-3133	83	31	latter	latter	ADJ
ijpds-3133	83	32	conforming	conforming	NOUN
ijpds-3133	83	33	substantially	substantially	ADV
ijpds-3133	83	34	to	to	ADP
ijpds-3133	83	35	the	the	DET
ijpds-3133	83	36	sclera	sclera	NOUN
ijpds-3133	83	37	of	of	ADP
ijpds-3133	83	38	the	the	DET
ijpds-3133	83	39	eye	eye	NOUN
ijpds-3133	83	40	.	.	PUNCT
ijpds-3133	84	1	the	the	DET
ijpds-3133	84	2	minidisc	minidisc	PROPN
ijpds-3133	84	3	is	be	AUX
ijpds-3133	84	4	a	a	DET
ijpds-3133	84	5	polymer	polymer	NOUN
ijpds-3133	84	6	of	of	ADP
ijpds-3133	84	7	hydroxyethyl	hydroxyethyl	NOUN
ijpds-3133	84	8	methacrylate	methacrylate	NOUN
ijpds-3133	84	9	and	and	CCONJ
ijpds-3133	84	10	ethylene	ethylene	NOUN
ijpds-3133	84	11	glycol	glycol	NOUN
ijpds-3133	84	12	methacrylate	methacrylate	NOUN
ijpds-3133	84	13	.	.	PUNCT
ijpds-3133	85	1	the	the	DET
ijpds-3133	85	2	size	size	NOUN
ijpds-3133	85	3	and	and	CCONJ
ijpds-3133	85	4	shape	shape	NOUN
ijpds-3133	85	5	of	of	ADP
ijpds-3133	85	6	the	the	DET
ijpds-3133	85	7	ots	ots	PROPN
ijpds-3133	85	8	allow	allow	VERB
ijpds-3133	85	9	easy	easy	ADJ
ijpds-3133	85	10	placement	placement	NOUN
ijpds-3133	85	11	of	of	ADP
ijpds-3133	85	12	the	the	DET
ijpds-3133	85	13	device	device	NOUN
ijpds-3133	85	14	under	under	ADP
ijpds-3133	85	15	either	either	CCONJ
ijpds-3133	85	16	upper	upper	ADJ
ijpds-3133	85	17	or	or	CCONJ
ijpds-3133	85	18	lower	low	ADJ
ijpds-3133	85	19	lid	lid	NOUN
ijpds-3133	85	20	without	without	ADP
ijpds-3133	85	21	any	any	DET
ijpds-3133	85	22	foreign	foreign	ADJ
ijpds-3133	85	23	body	body	NOUN
ijpds-3133	85	24	sensation	sensation	NOUN
ijpds-3133	85	25	,	,	PUNCT
ijpds-3133	85	26	distortion	distortion	NOUN
ijpds-3133	85	27	in	in	ADP
ijpds-3133	85	28	vision	vision	NOUN
ijpds-3133	85	29	,	,	PUNCT
ijpds-3133	85	30	or	or	CCONJ
ijpds-3133	85	31	decreased	decrease	VERB
ijpds-3133	85	32	oxygen	oxygen	NOUN
ijpds-3133	85	33	permeability	permeability	NOUN
ijpds-3133	85	34	.	.	PUNCT
ijpds-3133	86	1	new	new	ADJ
ijpds-3133	86	2	ophthalmic	ophthalmic	ADJ
ijpds-3133	86	3	delivery	delivery	NOUN
ijpds-3133	86	4	system	system	NOUN
ijpds-3133	86	5	(	(	PUNCT
ijpds-3133	86	6	nods	nod	NOUN
ijpds-3133	86	7	)	)	PUNCT
ijpds-3133	86	8	nods	nod	NOUN
ijpds-3133	86	9	is	be	AUX
ijpds-3133	86	10	used	use	VERB
ijpds-3133	86	11	for	for	ADP
ijpds-3133	86	12	delivering	deliver	VERB
ijpds-3133	86	13	drugs	drug	NOUN
ijpds-3133	86	14	in	in	ADP
ijpds-3133	86	15	precise	precise	ADJ
ijpds-3133	86	16	amounts	amount	NOUN
ijpds-3133	86	17	to	to	ADP
ijpds-3133	86	18	the	the	DET
ijpds-3133	86	19	eye	eye	NOUN
ijpds-3133	86	20	through	through	ADP
ijpds-3133	86	21	the	the	DET
ijpds-3133	86	22	lower	low	ADJ
ijpds-3133	86	23	conjunctival	conjunctival	NOUN
ijpds-3133	86	24	sac	sac	NOUN
ijpds-3133	86	25	using	use	VERB
ijpds-3133	86	26	a	a	DET
ijpds-3133	86	27	water	water	NOUN
ijpds-3133	86	28	-	-	PUNCT
ijpds-3133	86	29	soluble	soluble	ADJ
ijpds-3133	86	30	film	film	NOUN
ijpds-3133	86	31	loaded	load	VERB
ijpds-3133	86	32	with	with	ADP
ijpds-3133	86	33	the	the	DET
ijpds-3133	86	34	drug	drug	NOUN
ijpds-3133	86	35	[	[	X
ijpds-3133	86	36	22	22	NUM
ijpds-3133	86	37	]	]	PUNCT
ijpds-3133	86	38	.	.	PUNCT
ijpds-3133	87	1	the	the	DET
ijpds-3133	87	2	device	device	NOUN
ijpds-3133	87	3	consists	consist	VERB
ijpds-3133	87	4	of	of	ADP
ijpds-3133	87	5	20µm	20µm	ADJ
ijpds-3133	87	6	-	-	PUNCT
ijpds-3133	87	7	thick	thick	ADJ
ijpds-3133	87	8	,	,	PUNCT
ijpds-3133	87	9	4	4	NUM
ijpds-3133	87	10	×	×	NOUN
ijpds-3133	87	11	6	6	NUM
ijpds-3133	87	12	mm2	mm2	NOUN
ijpds-3133	87	13	medicated	medicate	VERB
ijpds-3133	87	14	flag	flag	NOUN
ijpds-3133	87	15	,	,	PUNCT
ijpds-3133	87	16	attached	attach	VERB
ijpds-3133	87	17	to	to	ADP
ijpds-3133	87	18	a	a	DET
ijpds-3133	87	19	0.7	0.7	NUM
ijpds-3133	87	20	-	-	PUNCT
ijpds-3133	87	21	mmlong	mmlong	NOUN
ijpds-3133	87	22	paper	paper	NOUN
ijpds-3133	87	23	-	-	PUNCT
ijpds-3133	87	24	covered	cover	VERB
ijpds-3133	87	25	handle	handle	NOUN
ijpds-3133	87	26	and	and	CCONJ
ijpds-3133	87	27	a	a	DET
ijpds-3133	87	28	3to	3to	NOUN
ijpds-3133	87	29	the	the	DET
ijpds-3133	87	30	4-µm	4-µm	NUM
ijpds-3133	87	31	-	-	PUNCT
ijpds-3133	87	32	thick	thick	ADJ
ijpds-3133	87	33	membrane	membrane	NOUN
ijpds-3133	87	34	.	.	PUNCT
ijpds-3133	88	1	nods	nod	NOUN
ijpds-3133	88	2	is	be	AUX
ijpds-3133	88	3	manufactured	manufacture	VERB
ijpds-3133	88	4	using	use	VERB
ijpds-3133	88	5	water	water	NOUN
ijpds-3133	88	6	-	-	PUNCT
ijpds-3133	88	7	soluble	soluble	ADJ
ijpds-3133	88	8	polyvinyl	polyvinyl	NOUN
ijpds-3133	88	9	alcohol	alcohol	NOUN
ijpds-3133	88	10	(	(	PUNCT
ijpds-3133	88	11	pva	pva	NOUN
ijpds-3133	88	12	)	)	PUNCT
ijpds-3133	88	13	.	.	PUNCT
ijpds-3133	89	1	greaves	greave	VERB
ijpds-3133	89	2	et	et	NOUN
ijpds-3133	89	3	al	al	PROPN
ijpds-3133	89	4	.	.	PUNCT
ijpds-3133	90	1	[	[	X
ijpds-3133	90	2	23	23	NUM
ijpds-3133	90	3	]	]	PUNCT
ijpds-3133	90	4	used	use	VERB
ijpds-3133	90	5	radiolabeled	radiolabele	VERB
ijpds-3133	90	6	nods	nod	NOUN
ijpds-3133	90	7	loaded	load	VERB
ijpds-3133	90	8	with	with	ADP
ijpds-3133	90	9	pilocarpine	pilocarpine	NOUN
ijpds-3133	90	10	nitrate	nitrate	NOUN
ijpds-3133	90	11	to	to	PART
ijpds-3133	90	12	evaluate	evaluate	VERB
ijpds-3133	90	13	the	the	DET
ijpds-3133	90	14	pharmacokinetics	pharmacokinetic	NOUN
ijpds-3133	90	15	and	and	CCONJ
ijpds-3133	90	16	bioavailability	bioavailability	NOUN
ijpds-3133	90	17	in	in	ADP
ijpds-3133	90	18	human	human	ADJ
ijpds-3133	90	19	subjects	subject	NOUN
ijpds-3133	90	20	.	.	PUNCT
ijpds-3133	91	1	topical	topical	ADJ
ijpds-3133	91	2	bimatoprost	bimatoprost	NOUN
ijpds-3133	91	3	ocular	ocular	ADJ
ijpds-3133	91	4	inserta	inserta	NOUN
ijpds-3133	91	5	bimatoprost	bimatoprost	ADV
ijpds-3133	91	6	-	-	PUNCT
ijpds-3133	91	7	loaded	load	VERB
ijpds-3133	91	8	insert	insert	NOUN
ijpds-3133	91	9	consisting	consist	VERB
ijpds-3133	91	10	of	of	ADP
ijpds-3133	91	11	a	a	DET
ijpds-3133	91	12	silicone	silicone	NOUN
ijpds-3133	91	13	matrix	matrix	NOUN
ijpds-3133	91	14	with	with	ADP
ijpds-3133	91	15	a	a	DET
ijpds-3133	91	16	polypropylene	polypropylene	NOUN
ijpds-3133	91	17	backbone	backbone	NOUN
ijpds-3133	91	18	for	for	ADP
ijpds-3133	91	19	sustained	sustained	ADJ
ijpds-3133	91	20	delivery	delivery	NOUN
ijpds-3133	91	21	to	to	PART
ijpds-3133	91	22	treat	treat	VERB
ijpds-3133	91	23	glaucoma	glaucoma	NOUN
ijpds-3133	91	24	underwent	underwent	NOUN
ijpds-3133	91	25	randomized	randomize	VERB
ijpds-3133	91	26	phase	phase	NOUN
ijpds-3133	91	27	ii	ii	NOUN
ijpds-3133	91	28	clinical	clinical	ADJ
ijpds-3133	91	29	trial	trial	NOUN
ijpds-3133	91	30	[	[	X
ijpds-3133	91	31	24	24	NUM
ijpds-3133	91	32	]	]	PUNCT
ijpds-3133	91	33	.	.	PUNCT
ijpds-3133	92	1	the	the	DET
ijpds-3133	92	2	diameter	diameter	NOUN
ijpds-3133	92	3	of	of	ADP
ijpds-3133	92	4	the	the	DET
ijpds-3133	92	5	insert	insert	NOUN
ijpds-3133	92	6	ranged	range	VERB
ijpds-3133	92	7	from	from	ADP
ijpds-3133	92	8	24	24	NUM
ijpds-3133	92	9	to	to	PART
ijpds-3133	92	10	29	29	NUM
ijpds-3133	92	11	mm	mm	NUM
ijpds-3133	92	12	and	and	CCONJ
ijpds-3133	92	13	was	be	AUX
ijpds-3133	92	14	placed	place	VERB
ijpds-3133	92	15	between	between	ADP
ijpds-3133	92	16	the	the	DET
ijpds-3133	92	17	upper	upper	ADJ
ijpds-3133	92	18	and	and	CCONJ
ijpds-3133	92	19	lower	low	ADJ
ijpds-3133	92	20	fornices	fornix	NOUN
ijpds-3133	92	21	.	.	PUNCT
ijpds-3133	93	1	the	the	DET
ijpds-3133	93	2	bimatoprost	bimatoprost	ADJ
ijpds-3133	93	3	ocular	ocular	ADJ
ijpds-3133	93	4	insert	insert	NOUN
ijpds-3133	93	5	elutes	elute	VERB
ijpds-3133	93	6	the	the	DET
ijpds-3133	93	7	drug	drug	NOUN
ijpds-3133	93	8	at	at	ADP
ijpds-3133	93	9	a	a	DET
ijpds-3133	93	10	variable	variable	ADJ
ijpds-3133	93	11	rate	rate	NOUN
ijpds-3133	93	12	for	for	ADP
ijpds-3133	93	13	six	six	NUM
ijpds-3133	93	14	months	month	NOUN
ijpds-3133	93	15	,	,	PUNCT
ijpds-3133	93	16	depending	depend	VERB
ijpds-3133	93	17	on	on	ADP
ijpds-3133	93	18	the	the	DET
ijpds-3133	93	19	polymer	polymer	NOUN
ijpds-3133	93	20	-	-	PUNCT
ijpds-3133	93	21	drug	drug	NOUN
ijpds-3133	93	22	matrix	matrix	NOUN
ijpds-3133	93	23	properties	property	NOUN
ijpds-3133	93	24	.	.	PUNCT
ijpds-3133	94	1	in	in	ADP
ijpds-3133	94	2	2016	2016	NUM
ijpds-3133	94	3	,	,	PUNCT
ijpds-3133	94	4	de	de	PROPN
ijpds-3133	94	5	souza	souza	PROPN
ijpds-3133	94	6	and	and	CCONJ
ijpds-3133	94	7	colleagues	colleague	NOUN
ijpds-3133	94	8	developed	develop	VERB
ijpds-3133	94	9	an	an	DET
ijpds-3133	94	10	ocular	ocular	ADJ
ijpds-3133	94	11	insert	insert	NOUN
ijpds-3133	94	12	with	with	ADP
ijpds-3133	94	13	mucoadhesive	mucoadhesive	ADJ
ijpds-3133	94	14	properties	property	NOUN
ijpds-3133	94	15	developed	develop	VERB
ijpds-3133	94	16	from	from	ADP
ijpds-3133	94	17	polymers	polymer	NOUN
ijpds-3133	94	18	of	of	ADP
ijpds-3133	94	19	chitosan	chitosan	NOUN
ijpds-3133	94	20	.	.	PUNCT
ijpds-3133	95	1	the	the	DET
ijpds-3133	95	2	data	datum	NOUN
ijpds-3133	95	3	from	from	ADP
ijpds-3133	95	4	the	the	DET
ijpds-3133	95	5	in	in	X
ijpds-3133	95	6	vitro	vitro	X
ijpds-3133	95	7	studies	study	NOUN
ijpds-3133	95	8	showed	show	VERB
ijpds-3133	95	9	sustained	sustained	ADJ
ijpds-3133	95	10	release	release	NOUN
ijpds-3133	95	11	of	of	ADP
ijpds-3133	95	12	brimonidine	brimonidine	NOUN
ijpds-3133	95	13	tartrate	tartrate	NOUN
ijpds-3133	95	14	.	.	PUNCT
ijpds-3133	96	1	moreover	moreover	ADV
ijpds-3133	96	2	,	,	PUNCT
ijpds-3133	96	3	the	the	DET
ijpds-3133	96	4	authors	author	NOUN
ijpds-3133	96	5	highlighted	highlight	VERB
ijpds-3133	96	6	the	the	DET
ijpds-3133	96	7	adherent	adherent	ADJ
ijpds-3133	96	8	properties	property	NOUN
ijpds-3133	96	9	of	of	ADP
ijpds-3133	96	10	the	the	DET
ijpds-3133	96	11	chitosan	chitosan	NOUN
ijpds-3133	96	12	-	-	PUNCT
ijpds-3133	96	13	based	base	VERB
ijpds-3133	96	14	polymer	polymer	NOUN
ijpds-3133	96	15	on	on	ADP
ijpds-3133	96	16	the	the	DET
ijpds-3133	96	17	conjunctiva	conjunctiva	NOUN
ijpds-3133	96	18	.	.	PUNCT
ijpds-3133	97	1	they	they	PRON
ijpds-3133	97	2	also	also	ADV
ijpds-3133	97	3	confirmed	confirm	VERB
ijpds-3133	97	4	the	the	DET
ijpds-3133	97	5	rate	rate	NOUN
ijpds-3133	97	6	of	of	ADP
ijpds-3133	97	7	constant	constant	ADJ
ijpds-3133	97	8	release	release	NOUN
ijpds-3133	97	9	for	for	ADP
ijpds-3133	97	10	a	a	DET
ijpds-3133	97	11	prolonged	prolonged	ADJ
ijpds-3133	97	12	period	period	NOUN
ijpds-3133	97	13	of	of	ADP
ijpds-3133	97	14	30	30	NUM
ijpds-3133	97	15	days	day	NOUN
ijpds-3133	97	16	without	without	ADP
ijpds-3133	97	17	an	an	DET
ijpds-3133	97	18	initial	initial	ADJ
ijpds-3133	97	19	burst	burst	NOUN
ijpds-3133	97	20	.	.	PUNCT
ijpds-3133	98	1	the	the	DET
ijpds-3133	98	2	insert	insert	NOUN
ijpds-3133	98	3	had	have	VERB
ijpds-3133	98	4	biocompatibility	biocompatibility	NOUN
ijpds-3133	98	5	with	with	ADP
ijpds-3133	98	6	the	the	DET
ijpds-3133	98	7	surrounding	surround	VERB
ijpds-3133	98	8	ocular	ocular	ADJ
ijpds-3133	98	9	tissues	tissue	NOUN
ijpds-3133	98	10	[	[	X
ijpds-3133	98	11	25	25	NUM
ijpds-3133	98	12	]	]	PUNCT
ijpds-3133	98	13	.	.	PUNCT
ijpds-3133	99	1	patient	patient	ADJ
ijpds-3133	99	2	education	education	NOUN
ijpds-3133	99	3	continues	continue	VERB
ijpds-3133	99	4	to	to	PART
ijpds-3133	99	5	be	be	AUX
ijpds-3133	99	6	a	a	DET
ijpds-3133	99	7	significant	significant	ADJ
ijpds-3133	99	8	challenge	challenge	NOUN
ijpds-3133	99	9	when	when	SCONJ
ijpds-3133	99	10	it	it	PRON
ijpds-3133	99	11	comes	come	VERB
ijpds-3133	99	12	to	to	ADP
ijpds-3133	99	13	the	the	DET
ijpds-3133	99	14	successful	successful	ADJ
ijpds-3133	99	15	use	use	NOUN
ijpds-3133	99	16	of	of	ADP
ijpds-3133	99	17	the	the	DET
ijpds-3133	99	18	inserts	insert	NOUN
ijpds-3133	99	19	as	as	SCONJ
ijpds-3133	99	20	it	it	PRON
ijpds-3133	99	21	requires	require	VERB
ijpds-3133	99	22	fine	fine	ADJ
ijpds-3133	99	23	manual	manual	ADJ
ijpds-3133	99	24	techniques	technique	NOUN
ijpds-3133	99	25	to	to	PART
ijpds-3133	99	26	manipulate	manipulate	VERB
ijpds-3133	99	27	and	and	CCONJ
ijpds-3133	99	28	place	place	VERB
ijpds-3133	99	29	the	the	DET
ijpds-3133	99	30	insert	insert	NOUN
ijpds-3133	99	31	.	.	PUNCT
ijpds-3133	100	1	it	it	PRON
ijpds-3133	100	2	was	be	AUX
ijpds-3133	100	3	seen	see	VERB
ijpds-3133	100	4	that	that	SCONJ
ijpds-3133	100	5	the	the	DET
ijpds-3133	100	6	level	level	NOUN
ijpds-3133	100	7	of	of	ADP
ijpds-3133	100	8	education	education	NOUN
ijpds-3133	100	9	and	and	CCONJ
ijpds-3133	100	10	age	age	NOUN
ijpds-3133	100	11	continue	continue	VERB
ijpds-3133	100	12	to	to	PART
ijpds-3133	100	13	be	be	AUX
ijpds-3133	100	14	the	the	DET
ijpds-3133	100	15	factors	factor	NOUN
ijpds-3133	100	16	that	that	PRON
ijpds-3133	100	17	govern	govern	VERB
ijpds-3133	100	18	the	the	DET
ijpds-3133	100	19	success	success	NOUN
ijpds-3133	100	20	of	of	ADP
ijpds-3133	100	21	these	these	DET
ijpds-3133	100	22	devices	device	NOUN
ijpds-3133	100	23	when	when	SCONJ
ijpds-3133	100	24	used	use	VERB
ijpds-3133	100	25	for	for	ADP
ijpds-3133	100	26	glaucoma	glaucoma	NOUN
ijpds-3133	101	1	[	[	X
ijpds-3133	101	2	26	26	NUM
ijpds-3133	101	3	]	]	PUNCT
ijpds-3133	101	4	.	.	PUNCT
ijpds-3133	102	1	hitoshi	hitoshi	PROPN
ijpds-3133	102	2	et	et	PROPN
ijpds-3133	102	3	al	al	PROPN
ijpds-3133	102	4	.	.	PROPN
ijpds-3133	102	5	studied	study	VERB
ijpds-3133	102	6	the	the	DET
ijpds-3133	102	7	efficacy	efficacy	NOUN
ijpds-3133	102	8	of	of	ADP
ijpds-3133	102	9	ophthalmic	ophthalmic	ADJ
ijpds-3133	102	10	inserts	insert	NOUN
ijpds-3133	102	11	of	of	ADP
ijpds-3133	102	12	timolol	timolol	NOUN
ijpds-3133	102	13	based	base	VERB
ijpds-3133	102	14	on	on	ADP
ijpds-3133	102	15	poly	poly	ADJ
ijpds-3133	102	16	(	(	PUNCT
ijpds-3133	102	17	2	2	NUM
ijpds-3133	102	18	-	-	PUNCT
ijpds-3133	102	19	hydroxypropyl	hydroxypropyl	NOUN
ijpds-3133	102	20	methacrylate	methacrylate	NOUN
ijpds-3133	102	21	)	)	PUNCT
ijpds-3133	102	22	and	and	CCONJ
ijpds-3133	102	23	poly	poly	ADJ
ijpds-3133	102	24	(	(	PUNCT
ijpds-3133	102	25	2	2	NUM
ijpds-3133	102	26	-	-	PUNCT
ijpds-3133	102	27	hydroxyethyl	hydroxyethyl	NOUN
ijpds-3133	102	28	methacrylate	methacrylate	NOUN
ijpds-3133	102	29	)	)	PUNCT
ijpds-3133	102	30	polymers	polymer	NOUN
ijpds-3133	102	31	.	.	PUNCT
ijpds-3133	103	1	the	the	DET
ijpds-3133	103	2	results	result	NOUN
ijpds-3133	103	3	from	from	ADP
ijpds-3133	103	4	the	the	DET
ijpds-3133	103	5	study	study	NOUN
ijpds-3133	103	6	indicated	indicate	VERB
ijpds-3133	103	7	that	that	SCONJ
ijpds-3133	103	8	the	the	DET
ijpds-3133	103	9	prepared	prepare	VERB
ijpds-3133	103	10	inserts	insert	NOUN
ijpds-3133	103	11	resulted	result	VERB
ijpds-3133	103	12	in	in	ADP
ijpds-3133	103	13	a	a	DET
ijpds-3133	103	14	controlled	control	VERB
ijpds-3133	103	15	release	release	NOUN
ijpds-3133	103	16	and	and	CCONJ
ijpds-3133	103	17	an	an	DET
ijpds-3133	103	18	improved	improved	ADJ
ijpds-3133	103	19	ocular	ocular	ADJ
ijpds-3133	103	20	bioavailability	bioavailability	NOUN
ijpds-3133	103	21	of	of	ADP
ijpds-3133	103	22	timolol	timolol	NOUN
ijpds-3133	104	1	[	[	X
ijpds-3133	104	2	27	27	NUM
ijpds-3133	104	3	]	]	PUNCT
ijpds-3133	104	4	.	.	PUNCT
ijpds-3133	105	1	soak	soak	NOUN
ijpds-3133	105	2	and	and	CCONJ
ijpds-3133	105	3	releasewaltman	releasewaltman	NOUN
ijpds-3133	105	4	and	and	CCONJ
ijpds-3133	105	5	kaufman	kaufman	NOUN
ijpds-3133	106	1	[	[	X
ijpds-3133	106	2	31	31	NUM
ijpds-3133	106	3	]	]	PUNCT
ijpds-3133	106	4	first	first	ADV
ijpds-3133	106	5	demonstrated	demonstrate	VERB
ijpds-3133	106	6	the	the	DET
ijpds-3133	106	7	potential	potential	ADJ
ijpds-3133	106	8	use	use	NOUN
ijpds-3133	106	9	of	of	ADP
ijpds-3133	106	10	hydrophilic	hydrophilic	ADJ
ijpds-3133	106	11	polymers	polymer	NOUN
ijpds-3133	106	12	of	of	ADP
ijpds-3133	106	13	2hydroxyethyl	2hydroxyethyl	PROPN
ijpds-3133	106	14	methacrylate	methacrylate	NOUN
ijpds-3133	106	15	(	(	PUNCT
ijpds-3133	106	16	hema	hema	PROPN
ijpds-3133	106	17	)	)	PUNCT
ijpds-3133	106	18	for	for	ADP
ijpds-3133	106	19	drug	drug	NOUN
ijpds-3133	106	20	delivery	delivery	NOUN
ijpds-3133	106	21	using	use	VERB
ijpds-3133	106	22	fluorescein	fluorescein	NOUN
ijpds-3133	106	23	stain	stain	NOUN
ijpds-3133	106	24	.	.	PUNCT
ijpds-3133	107	1	in	in	ADP
ijpds-3133	107	2	1974	1974	NUM
ijpds-3133	107	3	,	,	PUNCT
ijpds-3133	107	4	hillman	hillman	PROPN
ijpds-3133	107	5	demonstrated	demonstrate	VERB
ijpds-3133	107	6	the	the	DET
ijpds-3133	107	7	delivery	delivery	NOUN
ijpds-3133	107	8	of	of	ADP
ijpds-3133	107	9	antiglaucoma	antiglaucoma	NOUN
ijpds-3133	107	10	drugs	drug	NOUN
ijpds-3133	107	11	through	through	ADP
ijpds-3133	107	12	soft	soft	ADJ
ijpds-3133	107	13	contact	contact	NOUN
ijpds-3133	107	14	lenses	lense	NOUN
ijpds-3133	107	15	.	.	PUNCT
ijpds-3133	108	1	he	he	PRON
ijpds-3133	108	2	used	use	VERB
ijpds-3133	108	3	polymers	polymer	NOUN
ijpds-3133	108	4	of	of	ADP
ijpds-3133	108	5	vinylpyrrolidone	vinylpyrrolidone	NOUN
ijpds-3133	108	6	soaked	soak	VERB
ijpds-3133	108	7	in	in	ADP
ijpds-3133	108	8	1	1	NUM
ijpds-3133	108	9	%	%	NOUN
ijpds-3133	108	10	pilocarpine	pilocarpine	NOUN
ijpds-3133	108	11	for	for	ADP
ijpds-3133	108	12	drug	drug	NOUN
ijpds-3133	108	13	delivery	delivery	NOUN
ijpds-3133	108	14	.	.	PUNCT
ijpds-3133	109	1	he	he	PRON
ijpds-3133	109	2	reported	report	VERB
ijpds-3133	109	3	the	the	DET
ijpds-3133	109	4	system	system	NOUN
ijpds-3133	109	5	to	to	PART
ijpds-3133	109	6	be	be	AUX
ijpds-3133	109	7	as	as	ADV
ijpds-3133	109	8	efficacious	efficacious	ADJ
ijpds-3133	109	9	as	as	ADP
ijpds-3133	109	10	4	4	NUM
ijpds-3133	109	11	%	%	NOUN
ijpds-3133	109	12	pilocarpine	pilocarpine	NOUN
ijpds-3133	109	13	topical	topical	ADJ
ijpds-3133	109	14	eye	eye	NOUN
ijpds-3133	109	15	drops	drop	VERB
ijpds-3133	109	16	[	[	X
ijpds-3133	109	17	32	32	NUM
ijpds-3133	109	18	]	]	PUNCT
ijpds-3133	109	19	.	.	PUNCT
ijpds-3133	110	1	microemulsion	microemulsion	PROPN
ijpds-3133	110	2	loaded	load	VERB
ijpds-3133	110	3	lensesthe	lensesthe	PROPN
ijpds-3133	110	4	microemulsions	microemulsion	NOUN
ijpds-3133	110	5	for	for	ADP
ijpds-3133	110	6	drug	drug	NOUN
ijpds-3133	110	7	dispersal	dispersal	NOUN
ijpds-3133	110	8	were	be	AUX
ijpds-3133	110	9	favored	favor	VERB
ijpds-3133	110	10	due	due	ADP
ijpds-3133	110	11	to	to	ADP
ijpds-3133	110	12	the	the	DET
ijpds-3133	110	13	thermodynamic	thermodynamic	ADJ
ijpds-3133	110	14	stability	stability	NOUN
ijpds-3133	110	15	,	,	PUNCT
ijpds-3133	110	16	high	high	ADJ
ijpds-3133	110	17	drug	drug	NOUN
ijpds-3133	110	18	-	-	PUNCT
ijpds-3133	110	19	loading	loading	NOUN
ijpds-3133	110	20	capacity	capacity	NOUN
ijpds-3133	110	21	,	,	PUNCT
ijpds-3133	110	22	ease	ease	NOUN
ijpds-3133	110	23	of	of	ADP
ijpds-3133	110	24	preparation	preparation	NOUN
ijpds-3133	110	25	,	,	PUNCT
ijpds-3133	110	26	increased	increase	VERB
ijpds-3133	110	27	wettability	wettability	NOUN
ijpds-3133	110	28	,	,	PUNCT
ijpds-3133	110	29	and	and	CCONJ
ijpds-3133	110	30	easy	easy	ADJ
ijpds-3133	110	31	tailoring	tailoring	NOUN
ijpds-3133	110	32	of	of	ADP
ijpds-3133	110	33	the	the	DET
ijpds-3133	110	34	drug	drug	NOUN
ijpds-3133	110	35	release	release	NOUN
ijpds-3133	110	36	pattern	pattern	NOUN
ijpds-3133	110	37	.	.	PUNCT
ijpds-3133	111	1	multiple	multiple	ADJ
ijpds-3133	111	2	groups	group	NOUN
ijpds-3133	111	3	have	have	AUX
ijpds-3133	111	4	developed	develop	VERB
ijpds-3133	111	5	drug	drug	NOUN
ijpds-3133	111	6	-	-	PUNCT
ijpds-3133	111	7	loaded	load	VERB
ijpds-3133	111	8	microemulsionincorporating	microemulsionincorporating	NOUN
ijpds-3133	111	9	contact	contact	NOUN
ijpds-3133	111	10	lenses	lense	NOUN
ijpds-3133	111	11	[	[	X
ijpds-3133	111	12	48	48	NUM
ijpds-3133	111	13	]	]	PUNCT
ijpds-3133	111	14	.	.	PUNCT
ijpds-3133	112	1	gulsen	gulsen	NOUN
ijpds-3133	112	2	and	and	CCONJ
ijpds-3133	112	3	chauhan	chauhan	PROPN
ijpds-3133	112	4	encapsulated	encapsulate	VERB
ijpds-3133	112	5	timolol	timolol	NOUN
ijpds-3133	112	6	in	in	ADP
ijpds-3133	112	7	microemulsion	microemulsion	NOUN
ijpds-3133	112	8	stabilized	stabilize	VERB
ijpds-3133	112	9	within	within	ADP
ijpds-3133	112	10	a	a	DET
ijpds-3133	112	11	silica	silica	NOUN
ijpds-3133	112	12	shell	shell	NOUN
ijpds-3133	112	13	using	use	VERB
ijpds-3133	112	14	octadecyltrimethoxysilane	octadecyltrimethoxysilane	PROPN
ijpds-3133	112	15	(	(	PUNCT
ijpds-3133	112	16	otms	otms	NOUN
ijpds-3133	112	17	)	)	PUNCT
ijpds-3133	112	18	,	,	PUNCT
ijpds-3133	112	19	followed	follow	VERB
ijpds-3133	112	20	by	by	ADP
ijpds-3133	112	21	dispersion	dispersion	NOUN
ijpds-3133	112	22	in	in	ADP
ijpds-3133	112	23	a	a	DET
ijpds-3133	112	24	hydrogel	hydrogel	NOUN
ijpds-3133	112	25	lens	lens	NOUN
ijpds-3133	112	26	.	.	PUNCT
ijpds-3133	113	1	this	this	DET
ijpds-3133	113	2	model	model	NOUN
ijpds-3133	113	3	has	have	AUX
ijpds-3133	113	4	shown	show	VERB
ijpds-3133	113	5	sustained	sustained	ADJ
ijpds-3133	113	6	release	release	NOUN
ijpds-3133	113	7	of	of	ADP
ijpds-3133	113	8	up	up	ADP
ijpds-3133	113	9	to	to	PART
ijpds-3133	113	10	8	8	NUM
ijpds-3133	113	11	days	day	NOUN
ijpds-3133	113	12	without	without	ADP
ijpds-3133	113	13	affecting	affect	VERB
ijpds-3133	113	14	the	the	DET
ijpds-3133	113	15	transparency	transparency	NOUN
ijpds-3133	113	16	of	of	ADP
ijpds-3133	113	17	the	the	DET
ijpds-3133	113	18	lens	lens	NOUN
ijpds-3133	113	19	[	[	X
ijpds-3133	113	20	33	33	NUM
ijpds-3133	113	21	]	]	PUNCT
ijpds-3133	113	22	.	.	PUNCT
ijpds-3133	114	1	li	li	PROPN
ijpds-3133	114	2	et	et	PROPN
ijpds-3133	114	3	al	al	PROPN
ijpds-3133	114	4	.	.	PUNCT
ijpds-3133	115	1	[	[	X
ijpds-3133	115	2	34	34	NUM
ijpds-3133	115	3	]	]	PUNCT
ijpds-3133	115	4	developed	develop	VERB
ijpds-3133	115	5	contact	contact	NOUN
ijpds-3133	115	6	lenses	lense	NOUN
ijpds-3133	115	7	loaded	load	VERB
ijpds-3133	115	8	with	with	ADP
ijpds-3133	115	9	timolol	timolol	NOUN
ijpds-3133	115	10	,	,	PUNCT
ijpds-3133	115	11	with	with	ADP
ijpds-3133	115	12	oil	oil	NOUN
ijpds-3133	115	13	-	-	PUNCT
ijpds-3133	115	14	in	in	ADP
ijpds-3133	115	15	-	-	PUNCT
ijpds-3133	115	16	water	water	NOUN
ijpds-3133	115	17	-	-	PUNCT
ijpds-3133	115	18	type	type	NOUN
ijpds-3133	115	19	microemulsions	microemulsion	NOUN
ijpds-3133	115	20	using	use	VERB
ijpds-3133	115	21	a	a	DET
ijpds-3133	115	22	combination	combination	NOUN
ijpds-3133	115	23	of	of	ADP
ijpds-3133	115	24	ethyl	ethyl	PROPN
ijpds-3133	115	25	butyrate	butyrate	NOUN
ijpds-3133	115	26	,	,	PUNCT
ijpds-3133	115	27	and	and	CCONJ
ijpds-3133	115	28	pluronic	pluronic	ADJ
ijpds-3133	115	29	f127	f127	PROPN
ijpds-3133	115	30	.	.	PUNCT
ijpds-3133	116	1	the	the	DET
ijpds-3133	116	2	group	group	NOUN
ijpds-3133	116	3	fabricated	fabricate	VERB
ijpds-3133	116	4	the	the	DET
ijpds-3133	116	5	microemulsion	microemulsion	NOUN
ijpds-3133	116	6	-	-	PUNCT
ijpds-3133	116	7	laden	laden	NOUN
ijpds-3133	116	8	gels	gel	NOUN
ijpds-3133	116	9	,	,	PUNCT
ijpds-3133	116	10	ethyl	ethyl	PROPN
ijpds-3133	116	11	butyrate	butyrate	NOUN
ijpds-3133	116	12	/	/	SYM
ijpds-3133	116	13	water	water	NOUN
ijpds-3133	116	14	microemulsions	microemulsion	NOUN
ijpds-3133	116	15	stabilized	stabilize	VERB
ijpds-3133	116	16	by	by	ADP
ijpds-3133	116	17	pluronic	pluronic	ADJ
ijpds-3133	116	18	f127	f127	PROPN
ijpds-3133	116	19	surfactant	surfactant	NOUN
ijpds-3133	116	20	,	,	PUNCT
ijpds-3133	116	21	and	and	CCONJ
ijpds-3133	116	22	subsequently	subsequently	ADV
ijpds-3133	116	23	polymerized	polymerize	VERB
ijpds-3133	116	24	after	after	ADP
ijpds-3133	116	25	the	the	DET
ijpds-3133	116	26	addition	addition	NOUN
ijpds-3133	116	27	of	of	ADP
ijpds-3133	116	28	hema	hema	PROPN
ijpds-3133	116	29	.	.	PUNCT
ijpds-3133	117	1	vitamin	vitamin	NOUN
ijpds-3133	117	2	e	e	NOUN
ijpds-3133	117	3	–	–	PUNCT
ijpds-3133	117	4	loaded	load	VERB
ijpds-3133	117	5	lenseschauhan	lenseschauhan	PROPN
ijpds-3133	117	6	et	et	PROPN
ijpds-3133	117	7	al	al	PROPN
ijpds-3133	117	8	.	.	PROPN
ijpds-3133	117	9	developed	develop	VERB
ijpds-3133	117	10	the	the	DET
ijpds-3133	117	11	technique	technique	NOUN
ijpds-3133	117	12	using	use	VERB
ijpds-3133	117	13	vitamin	vitamin	NOUN
ijpds-3133	117	14	e	e	NOUN
ijpds-3133	117	15	as	as	ADP
ijpds-3133	117	16	an	an	DET
ijpds-3133	117	17	in	in	ADP
ijpds-3133	117	18	-	-	PUNCT
ijpds-3133	117	19	situ	situ	ADJ
ijpds-3133	117	20	transport	transport	NOUN
ijpds-3133	117	21	barrier	barrier	NOUN
ijpds-3133	117	22	for	for	ADP
ijpds-3133	117	23	timolol	timolol	NOUN
ijpds-3133	117	24	.	.	PUNCT
ijpds-3133	118	1	the	the	DET
ijpds-3133	118	2	drug	drug	NOUN
ijpds-3133	118	3	release	release	NOUN
ijpds-3133	118	4	was	be	AUX
ijpds-3133	118	5	significantly	significantly	ADV
ijpds-3133	118	6	increased	increase	VERB
ijpds-3133	118	7	by	by	ADP
ijpds-3133	118	8	elevating	elevate	VERB
ijpds-3133	118	9	the	the	DET
ijpds-3133	118	10	loading	loading	NOUN
ijpds-3133	118	11	concentration	concentration	NOUN
ijpds-3133	118	12	of	of	ADP
ijpds-3133	118	13	vitamin	vitamin	NOUN
ijpds-3133	118	14	e	e	NOUN
ijpds-3133	118	15	from	from	ADP
ijpds-3133	118	16	10	10	NUM
ijpds-3133	118	17	%	%	NOUN
ijpds-3133	118	18	to	to	PART
ijpds-3133	118	19	40	40	NUM
ijpds-3133	118	20	%	%	NOUN
ijpds-3133	118	21	in	in	ADP
ijpds-3133	118	22	contact	contact	NOUN
ijpds-3133	118	23	lenses	lense	NOUN
ijpds-3133	118	24	[	[	X
ijpds-3133	118	25	28	28	NUM
ijpds-3133	118	26	]	]	PUNCT
ijpds-3133	118	27	.	.	PUNCT
ijpds-3133	119	1	the	the	DET
ijpds-3133	119	2	group	group	NOUN
ijpds-3133	119	3	demonstrated	demonstrate	VERB
ijpds-3133	119	4	a	a	DET
ijpds-3133	119	5	quadratic	quadratic	ADJ
ijpds-3133	119	6	increase	increase	NOUN
ijpds-3133	119	7	in	in	ADP
ijpds-3133	119	8	drug	drug	NOUN
ijpds-3133	119	9	release	release	NOUN
ijpds-3133	119	10	duration	duration	NOUN
ijpds-3133	119	11	in	in	ADP
ijpds-3133	119	12	vitamin	vitamin	NOUN
ijpds-3133	119	13	e	e	NOUN
ijpds-3133	119	14	loading	loading	NOUN
ijpds-3133	119	15	.	.	PUNCT
ijpds-3133	120	1	loadings	loading	NOUN
ijpds-3133	120	2	of	of	ADP
ijpds-3133	120	3	10	10	NUM
ijpds-3133	120	4	%	%	NOUN
ijpds-3133	120	5	and	and	CCONJ
ijpds-3133	120	6	40	40	NUM
ijpds-3133	120	7	%	%	NOUN
ijpds-3133	120	8	vitamin	vitamin	NOUN
ijpds-3133	120	9	e	e	NOUN
ijpds-3133	120	10	increased	increase	VERB
ijpds-3133	120	11	the	the	DET
ijpds-3133	120	12	release	release	NOUN
ijpds-3133	120	13	time	time	NOUN
ijpds-3133	120	14	of	of	ADP
ijpds-3133	120	15	timolol	timolol	NOUN
ijpds-3133	120	16	by	by	ADP
ijpds-3133	120	17	a	a	DET
ijpds-3133	120	18	factor	factor	NOUN
ijpds-3133	120	19	of	of	ADP
ijpds-3133	120	20	about	about	ADV
ijpds-3133	120	21	5	5	NUM
ijpds-3133	120	22	and	and	CCONJ
ijpds-3133	120	23	400	400	NUM
ijpds-3133	120	24	,	,	PUNCT
ijpds-3133	120	25	respectively	respectively	ADV
ijpds-3133	120	26	.	.	PUNCT
ijpds-3133	121	1	however	however	ADV
ijpds-3133	121	2	,	,	PUNCT
ijpds-3133	121	3	vitamin	vitamin	NOUN
ijpds-3133	121	4	e	e	NOUN
ijpds-3133	121	5	loading	loading	NOUN
ijpds-3133	121	6	in	in	ADP
ijpds-3133	121	7	the	the	DET
ijpds-3133	121	8	lens	lens	NOUN
ijpds-3133	121	9	led	lead	VERB
ijpds-3133	121	10	to	to	ADP
ijpds-3133	121	11	an	an	DET
ijpds-3133	121	12	increase	increase	NOUN
ijpds-3133	121	13	in	in	ADP
ijpds-3133	121	14	lens	lens	NOUN
ijpds-3133	121	15	sizes	size	NOUN
ijpds-3133	121	16	,	,	PUNCT
ijpds-3133	121	17	a	a	DET
ijpds-3133	121	18	reduction	reduction	NOUN
ijpds-3133	121	19	in	in	ADP
ijpds-3133	121	20	oxygen	oxygen	NOUN
ijpds-3133	121	21	diffusion	diffusion	NOUN
ijpds-3133	121	22	,	,	PUNCT
ijpds-3133	121	23	and	and	CCONJ
ijpds-3133	121	24	a	a	DET
ijpds-3133	121	25	significant	significant	ADJ
ijpds-3133	121	26	decreament	decreament	NOUN
ijpds-3133	121	27	in	in	ADP
ijpds-3133	121	28	ion	ion	NOUN
ijpds-3133	121	29	permeability	permeability	NOUN
ijpds-3133	121	30	.	.	PUNCT
ijpds-3133	122	1	film	film	NOUN
ijpds-3133	122	2	impregnation	impregnation	NOUN
ijpds-3133	122	3	in	in	ADP
ijpds-3133	122	4	contact	contact	NOUN
ijpds-3133	122	5	lensciolino	lensciolino	PROPN
ijpds-3133	122	6	et	et	PROPN
ijpds-3133	122	7	al	al	PROPN
ijpds-3133	122	8	.	.	PUNCT
ijpds-3133	123	1	[	[	X
ijpds-3133	123	2	35	35	NUM
ijpds-3133	123	3	]	]	PUNCT
ijpds-3133	123	4	designed	design	VERB
ijpds-3133	123	5	a	a	DET
ijpds-3133	123	6	latanoprost	latanoprost	ADV
ijpds-3133	123	7	-	-	PUNCT
ijpds-3133	123	8	eluting	elute	VERB
ijpds-3133	123	9	contact	contact	NOUN
ijpds-3133	123	10	lens	lens	NOUN
ijpds-3133	123	11	for	for	ADP
ijpds-3133	123	12	treating	treat	VERB
ijpds-3133	123	13	glaucoma	glaucoma	NOUN
ijpds-3133	123	14	,	,	PUNCT
ijpds-3133	123	15	manufactured	manufacture	VERB
ijpds-3133	123	16	by	by	ADP
ijpds-3133	123	17	encapsulating	encapsulate	VERB
ijpds-3133	123	18	the	the	DET
ijpds-3133	123	19	drug	drug	NOUN
ijpds-3133	123	20	film	film	NOUN
ijpds-3133	123	21	enclosed	enclose	VERB
ijpds-3133	123	22	in	in	ADP
ijpds-3133	123	23	methafilcon	methafilcon	ADJ
ijpds-3133	123	24	lenses	lense	NOUN
ijpds-3133	123	25	.	.	PUNCT
ijpds-3133	124	1	these	these	DET
ijpds-3133	124	2	lenses	lense	NOUN
ijpds-3133	124	3	have	have	AUX
ijpds-3133	124	4	shown	show	VERB
ijpds-3133	124	5	sustained	sustained	ADJ
ijpds-3133	124	6	release	release	NOUN
ijpds-3133	124	7	for	for	ADP
ijpds-3133	124	8	up	up	ADP
ijpds-3133	124	9	to	to	PART
ijpds-3133	124	10	1	1	NUM
ijpds-3133	124	11	month	month	NOUN
ijpds-3133	124	12	in	in	ADP
ijpds-3133	124	13	glaucomatous	glaucomatous	ADJ
ijpds-3133	124	14	monkeys	monkey	NOUN
ijpds-3133	124	15	.	.	PUNCT
ijpds-3133	125	1	the	the	DET
ijpds-3133	125	2	amount	amount	NOUN
ijpds-3133	125	3	of	of	ADP
ijpds-3133	125	4	drug	drug	NOUN
ijpds-3133	125	5	delivered	deliver	VERB
ijpds-3133	125	6	to	to	ADP
ijpds-3133	125	7	the	the	DET
ijpds-3133	125	8	eye	eye	NOUN
ijpds-3133	125	9	exceeded	exceed	VERB
ijpds-3133	125	10	or	or	CCONJ
ijpds-3133	125	11	was	be	AUX
ijpds-3133	125	12	comparable	comparable	ADJ
ijpds-3133	125	13	to	to	ADP
ijpds-3133	125	14	the	the	DET
ijpds-3133	125	15	delivered	deliver	VERB
ijpds-3133	125	16	topical	topical	ADJ
ijpds-3133	125	17	drops	drop	NOUN
ijpds-3133	125	18	.	.	PUNCT
ijpds-3133	126	1	contact	contact	NOUN
ijpds-3133	126	2	lenses	lense	NOUN
ijpds-3133	126	3	with	with	ADP
ijpds-3133	126	4	polymer	polymer	NOUN
ijpds-3133	126	5	-	-	PUNCT
ijpds-3133	126	6	drug	drug	NOUN
ijpds-3133	126	7	films	film	NOUN
ijpds-3133	126	8	(	(	PUNCT
ijpds-3133	126	9	40–45	40–45	NUM
ijpds-3133	126	10	mm	mm	NOUN
ijpds-3133	126	11	in	in	ADP
ijpds-3133	126	12	thickness	thickness	NOUN
ijpds-3133	126	13	)	)	PUNCT
ijpds-3133	126	14	demonstrated	demonstrate	VERB
ijpds-3133	126	15	an	an	DET
ijpds-3133	126	16	initial	initial	ADJ
ijpds-3133	126	17	burst	burst	NOUN
ijpds-3133	126	18	of	of	ADP
ijpds-3133	126	19	latanoprost	latanoprost	NOUN
ijpds-3133	126	20	in	in	ADP
ijpds-3133	126	21	the	the	DET
ijpds-3133	126	22	aqueous	aqueous	ADJ
ijpds-3133	126	23	humor	humor	NOUN
ijpds-3133	126	24	,	,	PUNCT
ijpds-3133	126	25	a	a	DET
ijpds-3133	126	26	steady	steady	ADJ
ijpds-3133	126	27	concentration	concentration	NOUN
ijpds-3133	126	28	was	be	AUX
ijpds-3133	126	29	similar	similar	ADJ
ijpds-3133	126	30	to	to	ADP
ijpds-3133	126	31	the	the	DET
ijpds-3133	126	32	average	average	ADJ
ijpds-3133	126	33	hourly	hourly	ADJ
ijpds-3133	126	34	concentration	concentration	NOUN
ijpds-3133	126	35	rai	rai	X
ijpds-3133	126	36	et	et	NOUN
ijpds-3133	126	37	al	al	PROPN
ijpds-3133	126	38	mindful	mindful	ADJ
ijpds-3133	126	39	-	-	PUNCT
ijpds-3133	126	40	based	base	VERB
ijpds-3133	126	41	stress	stress	NOUN
ijpds-3133	126	42	reduction	reduction	NOUN
ijpds-3133	126	43	impact	impact	NOUN
ijpds-3133	126	44	vol	vol	NOUN
ijpds-3133	126	45	1	1	NUM
ijpds-3133	126	46	|	|	NOUN
ijpds-3133	126	47	issue	issue	NOUN
ijpds-3133	126	48	2	2	NUM
ijpds-3133	127	1	|	|	ADV
ijpds-3133	127	2	jul	jul	PROPN
ijpds-3133	127	3	–	–	PUNCT
ijpds-3133	127	4	sep	sep	PROPN
ijpds-3133	127	5	2022	2022	NUM
ijpds-3133	128	1	indian	indian	PROPN
ijpds-3133	128	2	j	j	PROPN
ijpds-3133	128	3	pharm	pharm	PROPN
ijpds-3133	128	4	drug	drug	PROPN
ijpds-3133	128	5	studies	study	NOUN
ijpds-3133	128	6	|	|	ADV
ijpds-3133	128	7	41	41	NUM
ijpds-3133	128	8	delivered	deliver	VERB
ijpds-3133	128	9	from	from	ADP
ijpds-3133	128	10	a	a	DET
ijpds-3133	128	11	drop	drop	NOUN
ijpds-3133	128	12	of	of	ADP
ijpds-3133	128	13	commercially	commercially	ADV
ijpds-3133	128	14	available	available	ADJ
ijpds-3133	128	15	latanoprost	latanoprost	ADJ
ijpds-3133	128	16	solution	solution	NOUN
ijpds-3133	128	17	[	[	X
ijpds-3133	128	18	52	52	NUM
ijpds-3133	128	19	]	]	PUNCT
ijpds-3133	128	20	.	.	PUNCT
ijpds-3133	129	1	enzyme	enzyme	NOUN
ijpds-3133	129	2	-	-	PUNCT
ijpds-3133	129	3	triggered	trigger	VERB
ijpds-3133	129	4	timolol	timolol	NOUN
ijpds-3133	129	5	releasekim	releasekim	PROPN
ijpds-3133	129	6	et	et	PROPN
ijpds-3133	129	7	al	al	PROPN
ijpds-3133	129	8	.	.	PUNCT
ijpds-3133	130	1	[	[	X
ijpds-3133	130	2	36	36	NUM
ijpds-3133	130	3	]	]	PUNCT
ijpds-3133	130	4	embedded	embed	VERB
ijpds-3133	130	5	nanodiamonds	nanodiamond	NOUN
ijpds-3133	130	6	(	(	PUNCT
ijpds-3133	130	7	nds	nds	PROPN
ijpds-3133	130	8	)	)	PUNCT
ijpds-3133	130	9	loaded	load	VERB
ijpds-3133	130	10	with	with	ADP
ijpds-3133	130	11	timolol	timolol	NOUN
ijpds-3133	130	12	in	in	ADP
ijpds-3133	130	13	contact	contact	NOUN
ijpds-3133	130	14	lenses	lense	NOUN
ijpds-3133	130	15	.	.	PUNCT
ijpds-3133	131	1	the	the	DET
ijpds-3133	131	2	nd	nd	NOUN
ijpds-3133	131	3	–	–	PUNCT
ijpds-3133	131	4	nanogel	nanogel	NOUN
ijpds-3133	131	5	embedded	embed	VERB
ijpds-3133	131	6	contact	contact	NOUN
ijpds-3133	131	7	lens	lens	NOUN
ijpds-3133	131	8	acts	act	VERB
ijpds-3133	131	9	as	as	ADP
ijpds-3133	131	10	an	an	DET
ijpds-3133	131	11	enzyme	enzyme	NOUN
ijpds-3133	131	12	trigger	trigger	NOUN
ijpds-3133	131	13	for	for	ADP
ijpds-3133	131	14	the	the	DET
ijpds-3133	131	15	delivery	delivery	NOUN
ijpds-3133	131	16	of	of	ADP
ijpds-3133	131	17	timolol	timolol	NOUN
ijpds-3133	131	18	.	.	PUNCT
ijpds-3133	132	1	the	the	DET
ijpds-3133	132	2	nanogels	nanogel	NOUN
ijpds-3133	132	3	sequester	sequester	VERB
ijpds-3133	132	4	timolol	timolol	NOUN
ijpds-3133	132	5	before	before	ADP
ijpds-3133	132	6	activating	activate	VERB
ijpds-3133	132	7	the	the	DET
ijpds-3133	132	8	lysozyme	lysozyme	NOUN
ijpds-3133	132	9	that	that	PRON
ijpds-3133	132	10	causes	cause	VERB
ijpds-3133	132	11	chitosan	chitosan	ADJ
ijpds-3133	132	12	degradation	degradation	NOUN
ijpds-3133	132	13	and	and	CCONJ
ijpds-3133	132	14	subsequently	subsequently	ADV
ijpds-3133	132	15	allows	allow	VERB
ijpds-3133	132	16	sustained	sustained	ADJ
ijpds-3133	132	17	drug	drug	NOUN
ijpds-3133	132	18	release	release	NOUN
ijpds-3133	132	19	.	.	PUNCT
ijpds-3133	133	1	after	after	ADP
ijpds-3133	133	2	24	24	NUM
ijpds-3133	133	3	-	-	PUNCT
ijpds-3133	133	4	h	h	NOUN
ijpds-3133	133	5	treatment	treatment	NOUN
ijpds-3133	133	6	with	with	ADP
ijpds-3133	133	7	lysozyme	lysozyme	NOUN
ijpds-3133	133	8	,	,	PUNCT
ijpds-3133	133	9	the	the	DET
ijpds-3133	133	10	total	total	ADJ
ijpds-3133	133	11	steady	steady	ADJ
ijpds-3133	133	12	drug	drug	NOUN
ijpds-3133	133	13	release	release	NOUN
ijpds-3133	133	14	from	from	ADP
ijpds-3133	133	15	the	the	DET
ijpds-3133	133	16	lens	lens	NOUN
ijpds-3133	133	17	was	be	AUX
ijpds-3133	133	18	9.41	9.41	NUM
ijpds-3133	133	19	μg	μg	NOUN
ijpds-3133	133	20	.	.	PUNCT
ijpds-3133	134	1	intraocular	intraocular	ADJ
ijpds-3133	134	2	implants	implant	NOUN
ijpds-3133	134	3	intravitreal	intravitreal	ADJ
ijpds-3133	134	4	implantsintravitreal	implantsintravitreal	ADJ
ijpds-3133	134	5	implants	implant	NOUN
ijpds-3133	134	6	are	be	AUX
ijpds-3133	134	7	devices	device	NOUN
ijpds-3133	134	8	capable	capable	ADJ
ijpds-3133	134	9	of	of	ADP
ijpds-3133	134	10	delivering	deliver	VERB
ijpds-3133	134	11	drugs	drug	NOUN
ijpds-3133	134	12	for	for	ADP
ijpds-3133	134	13	a	a	DET
ijpds-3133	134	14	prolonged	prolonged	ADJ
ijpds-3133	134	15	duration	duration	NOUN
ijpds-3133	134	16	in	in	ADP
ijpds-3133	134	17	the	the	DET
ijpds-3133	134	18	eye	eye	NOUN
ijpds-3133	134	19	.	.	PUNCT
ijpds-3133	135	1	although	although	SCONJ
ijpds-3133	135	2	surgical	surgical	ADJ
ijpds-3133	135	3	implants	implant	NOUN
ijpds-3133	135	4	present	present	VERB
ijpds-3133	135	5	a	a	DET
ijpds-3133	135	6	viable	viable	ADJ
ijpds-3133	135	7	option	option	NOUN
ijpds-3133	135	8	for	for	ADP
ijpds-3133	135	9	longterm	longterm	ADJ
ijpds-3133	135	10	drug	drug	NOUN
ijpds-3133	135	11	delivery	delivery	NOUN
ijpds-3133	135	12	,	,	PUNCT
ijpds-3133	135	13	the	the	DET
ijpds-3133	135	14	invasive	invasive	ADJ
ijpds-3133	135	15	nature	nature	NOUN
ijpds-3133	135	16	of	of	ADP
ijpds-3133	135	17	the	the	DET
ijpds-3133	135	18	initial	initial	ADJ
ijpds-3133	135	19	and	and	CCONJ
ijpds-3133	135	20	subsequent	subsequent	ADJ
ijpds-3133	135	21	surgical	surgical	ADJ
ijpds-3133	135	22	procedures	procedure	NOUN
ijpds-3133	135	23	to	to	PART
ijpds-3133	135	24	remove	remove	VERB
ijpds-3133	135	25	the	the	DET
ijpds-3133	135	26	implants	implant	NOUN
ijpds-3133	135	27	does	do	AUX
ijpds-3133	135	28	not	not	PART
ijpds-3133	135	29	make	make	VERB
ijpds-3133	135	30	them	they	PRON
ijpds-3133	135	31	a	a	DET
ijpds-3133	135	32	favorable	favorable	ADJ
ijpds-3133	135	33	choice	choice	NOUN
ijpds-3133	135	34	for	for	ADP
ijpds-3133	135	35	drug	drug	NOUN
ijpds-3133	135	36	delivery	delivery	NOUN
ijpds-3133	135	37	.	.	PUNCT
ijpds-3133	136	1	ozurdex	ozurdex	NOUN
ijpds-3133	136	2	is	be	AUX
ijpds-3133	136	3	a	a	DET
ijpds-3133	136	4	degradable	degradable	ADJ
ijpds-3133	136	5	dexamethasone	dexamethasone	NOUN
ijpds-3133	136	6	intravitreal	intravitreal	NOUN
ijpds-3133	136	7	implant	implant	NOUN
ijpds-3133	136	8	produced	produce	VERB
ijpds-3133	136	9	by	by	ADP
ijpds-3133	136	10	allergan	allergan	PROPN
ijpds-3133	136	11	,	,	PUNCT
ijpds-3133	136	12	which	which	PRON
ijpds-3133	136	13	was	be	AUX
ijpds-3133	136	14	used	use	VERB
ijpds-3133	136	15	to	to	PART
ijpds-3133	136	16	treat	treat	VERB
ijpds-3133	136	17	macular	macular	ADJ
ijpds-3133	136	18	edema	edema	NOUN
ijpds-3133	136	19	and	and	CCONJ
ijpds-3133	136	20	noninfectious	noninfectious	ADJ
ijpds-3133	136	21	uveitis	uveitis	NOUN
ijpds-3133	136	22	[	[	X
ijpds-3133	136	23	53	53	NUM
ijpds-3133	136	24	]	]	PUNCT
ijpds-3133	136	25	.	.	PUNCT
ijpds-3133	137	1	the	the	DET
ijpds-3133	137	2	device	device	NOUN
ijpds-3133	137	3	slowly	slowly	ADV
ijpds-3133	137	4	degrades	degrade	VERB
ijpds-3133	137	5	after	after	ADP
ijpds-3133	137	6	implantation	implantation	NOUN
ijpds-3133	137	7	in	in	ADP
ijpds-3133	137	8	the	the	DET
ijpds-3133	137	9	vitreous	vitreous	ADJ
ijpds-3133	137	10	while	while	SCONJ
ijpds-3133	137	11	delivering	deliver	VERB
ijpds-3133	137	12	dexamethasone	dexamethasone	NOUN
ijpds-3133	137	13	.	.	PUNCT
ijpds-3133	138	1	the	the	DET
ijpds-3133	138	2	manufacturer	manufacturer	NOUN
ijpds-3133	138	3	conducts	conduct	VERB
ijpds-3133	138	4	clinical	clinical	ADJ
ijpds-3133	138	5	trials	trial	NOUN
ijpds-3133	138	6	of	of	ADP
ijpds-3133	138	7	the	the	DET
ijpds-3133	138	8	implants	implant	NOUN
ijpds-3133	138	9	loaded	load	VERB
ijpds-3133	138	10	with	with	ADP
ijpds-3133	138	11	brimonidine	brimonidine	NOUN
ijpds-3133	138	12	tartrate	tartrate	NOUN
ijpds-3133	138	13	in	in	ADP
ijpds-3133	138	14	the	the	DET
ijpds-3133	138	15	proprietary	proprietary	ADJ
ijpds-3133	138	16	novadur	novadur	PROPN
ijpds-3133	138	17	poly	poly	ADJ
ijpds-3133	138	18	(	(	PUNCT
ijpds-3133	138	19	lactic	lactic	ADJ
ijpds-3133	138	20	-	-	PUNCT
ijpds-3133	138	21	coglycolic	coglycolic	NOUN
ijpds-3133	138	22	acid	acid	NOUN
ijpds-3133	138	23	)	)	PUNCT
ijpds-3133	138	24	(	(	PUNCT
ijpds-3133	138	25	plga	plga	NOUN
ijpds-3133	138	26	)	)	PUNCT
ijpds-3133	138	27	intravitreal	intravitreal	ADJ
ijpds-3133	138	28	polymer	polymer	NOUN
ijpds-3133	138	29	matrix	matrix	NOUN
ijpds-3133	138	30	platform	platform	NOUN
ijpds-3133	138	31	for	for	ADP
ijpds-3133	138	32	the	the	DET
ijpds-3133	138	33	management	management	NOUN
ijpds-3133	138	34	of	of	ADP
ijpds-3133	138	35	geographic	geographic	ADJ
ijpds-3133	138	36	atrophy	atrophy	NOUN
ijpds-3133	138	37	due	due	ADJ
ijpds-3133	138	38	to	to	ADP
ijpds-3133	138	39	agerelated	agerelate	VERB
ijpds-3133	138	40	macular	macular	ADJ
ijpds-3133	138	41	degeneration	degeneration	NOUN
ijpds-3133	138	42	.	.	PUNCT
ijpds-3133	139	1	topical	topical	ADJ
ijpds-3133	139	2	daily	daily	ADJ
ijpds-3133	139	3	ophthalmic	ophthalmic	ADJ
ijpds-3133	139	4	brimonidine	brimonidine	NOUN
ijpds-3133	139	5	tartrate	tartrate	NOUN
ijpds-3133	139	6	drops	drop	NOUN
ijpds-3133	139	7	were	be	AUX
ijpds-3133	139	8	prescribed	prescribe	VERB
ijpds-3133	139	9	for	for	ADP
ijpds-3133	139	10	iop	iop	NOUN
ijpds-3133	139	11	reduction	reduction	NOUN
ijpds-3133	139	12	and	and	CCONJ
ijpds-3133	139	13	neuroprotective	neuroprotective	ADJ
ijpds-3133	139	14	effect	effect	NOUN
ijpds-3133	139	15	.	.	PUNCT
ijpds-3133	140	1	if	if	SCONJ
ijpds-3133	140	2	the	the	DET
ijpds-3133	140	3	novadur	novadur	ADJ
ijpds-3133	140	4	plga	plga	NOUN
ijpds-3133	140	5	platform	platform	NOUN
ijpds-3133	140	6	implants	implant	NOUN
ijpds-3133	140	7	with	with	ADP
ijpds-3133	140	8	brimonidine	brimonidine	NOUN
ijpds-3133	140	9	tartrate	tartrate	NOUN
ijpds-3133	140	10	are	be	AUX
ijpds-3133	140	11	approved	approve	VERB
ijpds-3133	140	12	,	,	PUNCT
ijpds-3133	140	13	they	they	PRON
ijpds-3133	140	14	can	can	AUX
ijpds-3133	140	15	also	also	ADV
ijpds-3133	140	16	be	be	AUX
ijpds-3133	140	17	adapted	adapt	VERB
ijpds-3133	140	18	for	for	ADP
ijpds-3133	140	19	use	use	NOUN
ijpds-3133	140	20	in	in	ADP
ijpds-3133	140	21	glaucoma	glaucoma	NOUN
ijpds-3133	140	22	patients	patient	NOUN
ijpds-3133	140	23	[	[	X
ijpds-3133	140	24	37	37	NUM
ijpds-3133	140	25	]	]	PUNCT
ijpds-3133	140	26	.	.	PUNCT
ijpds-3133	141	1	subconjunctival	subconjunctival	PROPN
ijpds-3133	141	2	inserts	insert	NOUN
ijpds-3133	141	3	-	-	PUNCT
ijpds-3133	141	4	the	the	DET
ijpds-3133	141	5	subconjunctival	subconjunctival	NOUN
ijpds-3133	141	6	inserts	insert	NOUN
ijpds-3133	141	7	were	be	AUX
ijpds-3133	141	8	used	use	VERB
ijpds-3133	141	9	as	as	ADP
ijpds-3133	141	10	implants	implant	NOUN
ijpds-3133	141	11	as	as	ADP
ijpds-3133	141	12	a	a	DET
ijpds-3133	141	13	replacement	replacement	NOUN
ijpds-3133	141	14	for	for	ADP
ijpds-3133	141	15	viscoelastic	viscoelastic	ADJ
ijpds-3133	141	16	depot	depot	NOUN
ijpds-3133	141	17	delivery	delivery	NOUN
ijpds-3133	141	18	injections	injection	NOUN
ijpds-3133	141	19	.	.	PUNCT
ijpds-3133	142	1	the	the	DET
ijpds-3133	142	2	vs101	vs101	PROPN
ijpds-3133	142	3	ocular	ocular	ADJ
ijpds-3133	142	4	insert	insert	NOUN
ijpds-3133	142	5	was	be	AUX
ijpds-3133	142	6	one	one	NUM
ijpds-3133	142	7	such	such	ADJ
ijpds-3133	142	8	insert	insert	NOUN
ijpds-3133	142	9	developed	develop	VERB
ijpds-3133	142	10	by	by	ADP
ijpds-3133	142	11	visci	visci	PROPN
ijpds-3133	142	12	inc	inc	PROPN
ijpds-3133	142	13	.	.	PROPN
ijpds-3133	142	14	in	in	ADP
ijpds-3133	142	15	2014	2014	NUM
ijpds-3133	142	16	and	and	CCONJ
ijpds-3133	142	17	later	later	ADV
ijpds-3133	142	18	underwent	undergo	VERB
ijpds-3133	142	19	a	a	DET
ijpds-3133	142	20	phase	phase	NOUN
ijpds-3133	142	21	i	i	PRON
ijpds-3133	142	22	/	/	SYM
ijpds-3133	142	23	ii	ii	PROPN
ijpds-3133	142	24	multicentric	multicentric	NOUN
ijpds-3133	142	25	randomized	randomize	VERB
ijpds-3133	142	26	control	control	NOUN
ijpds-3133	142	27	study	study	NOUN
ijpds-3133	142	28	to	to	PART
ijpds-3133	142	29	evaluate	evaluate	VERB
ijpds-3133	142	30	the	the	DET
ijpds-3133	142	31	safety	safety	NOUN
ijpds-3133	142	32	and	and	CCONJ
ijpds-3133	142	33	effectiveness	effectiveness	NOUN
ijpds-3133	142	34	of	of	ADP
ijpds-3133	142	35	subconjunctival	subconjunctival	ADJ
ijpds-3133	142	36	latanoprost	latanoprost	VERB
ijpds-3133	142	37	insert	insert	NOUN
ijpds-3133	142	38	in	in	ADP
ijpds-3133	142	39	subjects	subject	NOUN
ijpds-3133	142	40	with	with	ADP
ijpds-3133	142	41	ocular	ocular	ADJ
ijpds-3133	142	42	hypertension	hypertension	NOUN
ijpds-3133	142	43	or	or	CCONJ
ijpds-3133	142	44	oag	oag	X
ijpds-3133	143	1	[	[	X
ijpds-3133	143	2	38	38	NUM
ijpds-3133	143	3	]	]	PUNCT
ijpds-3133	143	4	.	.	PUNCT
ijpds-3133	144	1	pcl	pcl	PROPN
ijpds-3133	144	2	-	-	PUNCT
ijpds-3133	144	3	peg	peg	NOUN
ijpds-3133	144	4	inserts	insert	NOUN
ijpds-3133	144	5	-	-	PUNCT
ijpds-3133	144	6	ng	ng	PROPN
ijpds-3133	144	7	and	and	CCONJ
ijpds-3133	144	8	colleagues	colleague	NOUN
ijpds-3133	144	9	used	use	VERB
ijpds-3133	144	10	biodegradable	biodegradable	ADJ
ijpds-3133	144	11	microfilm	microfilm	NOUN
ijpds-3133	144	12	synthesized	synthesize	VERB
ijpds-3133	144	13	by	by	ADP
ijpds-3133	144	14	a	a	DET
ijpds-3133	144	15	combination	combination	NOUN
ijpds-3133	144	16	of	of	ADP
ijpds-3133	144	17	poly	poly	ADJ
ijpds-3133	144	18	(	(	PUNCT
ijpds-3133	144	19	lactide)/poly	lactide)/poly	ADJ
ijpds-3133	144	20	(	(	PUNCT
ijpds-3133	144	21	ε	ε	NOUN
ijpds-3133	144	22	-	-	PUNCT
ijpds-3133	144	23	caprolactone	caprolactone	NOUN
ijpds-3133	144	24	)	)	PUNCT
ijpds-3133	144	25	(	(	PUNCT
ijpds-3133	144	26	plc	plc	NOUN
ijpds-3133	144	27	)	)	PUNCT
ijpds-3133	144	28	and	and	CCONJ
ijpds-3133	144	29	poly	poly	ADJ
ijpds-3133	144	30	(	(	PUNCT
ijpds-3133	144	31	εcaprolactone)/poly	εcaprolactone)/poly	ADJ
ijpds-3133	144	32	(	(	PUNCT
ijpds-3133	144	33	ethylene	ethylene	NOUN
ijpds-3133	144	34	glycol	glycol	NOUN
ijpds-3133	144	35	)	)	PUNCT
ijpds-3133	144	36	(	(	PUNCT
ijpds-3133	144	37	plc	plc	PROPN
ijpds-3133	144	38	/	/	SYM
ijpds-3133	144	39	pcl	pcl	PROPN
ijpds-3133	144	40	-	-	PUNCT
ijpds-3133	144	41	peg	peg	NOUN
ijpds-3133	144	42	)	)	PUNCT
ijpds-3133	144	43	.	.	PUNCT
ijpds-3133	145	1	the	the	DET
ijpds-3133	145	2	polymer	polymer	NOUN
ijpds-3133	145	3	was	be	AUX
ijpds-3133	145	4	loaded	load	VERB
ijpds-3133	145	5	with	with	ADP
ijpds-3133	145	6	timolol	timolol	NOUN
ijpds-3133	145	7	maleate	maleate	NOUN
ijpds-3133	145	8	and	and	CCONJ
ijpds-3133	145	9	inserted	insert	VERB
ijpds-3133	145	10	by	by	ADP
ijpds-3133	145	11	conjunctival	conjunctival	ADJ
ijpds-3133	145	12	dissection	dissection	NOUN
ijpds-3133	145	13	[	[	X
ijpds-3133	145	14	39	39	NUM
ijpds-3133	145	15	]	]	PUNCT
ijpds-3133	145	16	.	.	PUNCT
ijpds-3133	146	1	the	the	DET
ijpds-3133	146	2	authors	author	NOUN
ijpds-3133	146	3	reported	report	VERB
ijpds-3133	146	4	a	a	DET
ijpds-3133	146	5	decrease	decrease	NOUN
ijpds-3133	146	6	of	of	ADP
ijpds-3133	146	7	50.1	50.1	NUM
ijpds-3133	146	8	%	%	NOUN
ijpds-3133	146	9	±	±	NUM
ijpds-3133	146	10	8.5	8.5	NUM
ijpds-3133	146	11	%	%	NOUN
ijpds-3133	146	12	in	in	ADP
ijpds-3133	146	13	iop	iop	PROPN
ijpds-3133	146	14	from	from	ADP
ijpds-3133	146	15	baseline	baseline	NOUN
ijpds-3133	146	16	in	in	ADP
ijpds-3133	146	17	primates	primate	NOUN
ijpds-3133	146	18	with	with	ADP
ijpds-3133	146	19	ocular	ocular	ADJ
ijpds-3133	146	20	hypertension	hypertension	NOUN
ijpds-3133	146	21	,	,	PUNCT
ijpds-3133	146	22	which	which	PRON
ijpds-3133	146	23	was	be	AUX
ijpds-3133	146	24	sustained	sustain	VERB
ijpds-3133	146	25	for	for	ADP
ijpds-3133	146	26	140	140	NUM
ijpds-3133	146	27	days	day	NOUN
ijpds-3133	146	28	.	.	PUNCT
ijpds-3133	147	1	ap	ap	PROPN
ijpds-3133	147	2	-	-	PUNCT
ijpds-3133	147	3	pcl	pcl	PROPN
ijpds-3133	147	4	inserts	insert	NOUN
ijpds-3133	147	5	-	-	PUNCT
ijpds-3133	147	6	alkoxylphenacyl	alkoxylphenacyl	NOUN
ijpds-3133	147	7	-	-	PUNCT
ijpds-3133	147	8	based	base	VERB
ijpds-3133	147	9	polycarbonate	polycarbonate	NOUN
ijpds-3133	147	10	polymers	polymer	NOUN
ijpds-3133	147	11	in	in	ADP
ijpds-3133	147	12	combination	combination	NOUN
ijpds-3133	147	13	with	with	ADP
ijpds-3133	147	14	polycaprolactone	polycaprolactone	NOUN
ijpds-3133	147	15	(	(	PUNCT
ijpds-3133	147	16	ap	ap	PROPN
ijpds-3133	147	17	-	-	PUNCT
ijpds-3133	147	18	pcl	pcl	PROPN
ijpds-3133	147	19	)	)	PUNCT
ijpds-3133	147	20	were	be	AUX
ijpds-3133	147	21	used	use	VERB
ijpds-3133	147	22	by	by	ADP
ijpds-3133	147	23	manickavasagam	manickavasagam	PROPN
ijpds-3133	147	24	et	et	PROPN
ijpds-3133	147	25	al	al	PROPN
ijpds-3133	147	26	.	.	PUNCT
ijpds-3133	148	1	[	[	X
ijpds-3133	148	2	40	40	NUM
ijpds-3133	148	3	]	]	PUNCT
ijpds-3133	148	4	for	for	ADP
ijpds-3133	148	5	sustaining	sustain	VERB
ijpds-3133	148	6	delivery	delivery	NOUN
ijpds-3133	148	7	of	of	ADP
ijpds-3133	148	8	brimonidine	brimonidine	NOUN
ijpds-3133	148	9	tartrate	tartrate	VERB
ijpds-3133	148	10	for	for	ADP
ijpds-3133	148	11	three	three	NUM
ijpds-3133	148	12	months	month	NOUN
ijpds-3133	148	13	.	.	PUNCT
ijpds-3133	149	1	the	the	DET
ijpds-3133	149	2	major	major	ADJ
ijpds-3133	149	3	drawback	drawback	NOUN
ijpds-3133	149	4	attributed	attribute	VERB
ijpds-3133	149	5	to	to	ADP
ijpds-3133	149	6	the	the	DET
ijpds-3133	149	7	subconjunctival	subconjunctival	NOUN
ijpds-3133	149	8	inserts	insert	NOUN
ijpds-3133	149	9	is	be	AUX
ijpds-3133	149	10	the	the	DET
ijpds-3133	149	11	requirement	requirement	NOUN
ijpds-3133	149	12	of	of	ADP
ijpds-3133	149	13	a	a	DET
ijpds-3133	149	14	surgically	surgically	ADV
ijpds-3133	149	15	invasive	invasive	ADJ
ijpds-3133	149	16	procedure	procedure	NOUN
ijpds-3133	149	17	which	which	PRON
ijpds-3133	149	18	creates	create	VERB
ijpds-3133	149	19	a	a	DET
ijpds-3133	149	20	small	small	ADJ
ijpds-3133	149	21	opening	opening	NOUN
ijpds-3133	149	22	in	in	ADP
ijpds-3133	149	23	the	the	DET
ijpds-3133	149	24	conjunctiva	conjunctiva	NOUN
ijpds-3133	149	25	with	with	ADP
ijpds-3133	149	26	a	a	DET
ijpds-3133	149	27	possibility	possibility	NOUN
ijpds-3133	149	28	of	of	ADP
ijpds-3133	149	29	subconjunctival	subconjunctival	ADJ
ijpds-3133	149	30	migration	migration	NOUN
ijpds-3133	149	31	,	,	PUNCT
ijpds-3133	149	32	infection	infection	NOUN
ijpds-3133	149	33	in	in	ADP
ijpds-3133	149	34	need	need	NOUN
ijpds-3133	149	35	of	of	ADP
ijpds-3133	149	36	an	an	DET
ijpds-3133	149	37	operating	operating	NOUN
ijpds-3133	149	38	room	room	NOUN
ijpds-3133	149	39	procedure	procedure	NOUN
ijpds-3133	149	40	for	for	ADP
ijpds-3133	149	41	insertion	insertion	NOUN
ijpds-3133	149	42	/	/	SYM
ijpds-3133	149	43	removal	removal	NOUN
ijpds-3133	149	44	of	of	ADP
ijpds-3133	149	45	the	the	DET
ijpds-3133	149	46	device	device	NOUN
ijpds-3133	149	47	.	.	PUNCT
ijpds-3133	150	1	micro	micro	ADJ
ijpds-3133	150	2	electro	electro	ADJ
ijpds-3133	150	3	-	-	PUNCT
ijpds-3133	150	4	mechanical	mechanical	ADJ
ijpds-3133	150	5	system	system	NOUN
ijpds-3133	150	6	-	-	PUNCT
ijpds-3133	150	7	the	the	DET
ijpds-3133	150	8	system	system	NOUN
ijpds-3133	150	9	termed	term	VERB
ijpds-3133	150	10	as	as	ADP
ijpds-3133	150	11	micro	micro	X
ijpds-3133	150	12	electro	electro	VERB
ijpds-3133	150	13	mechanical	mechanical	ADJ
ijpds-3133	150	14	system	system	NOUN
ijpds-3133	150	15	(	(	PUNCT
ijpds-3133	150	16	mems	mem	NOUN
ijpds-3133	150	17	)	)	PUNCT
ijpds-3133	150	18	works	work	VERB
ijpds-3133	150	19	on	on	ADP
ijpds-3133	150	20	the	the	DET
ijpds-3133	150	21	principle	principle	NOUN
ijpds-3133	150	22	of	of	ADP
ijpds-3133	150	23	bubble	bubble	NOUN
ijpds-3133	150	24	generation	generation	NOUN
ijpds-3133	150	25	by	by	ADP
ijpds-3133	150	26	electrolysis	electrolysis	NOUN
ijpds-3133	150	27	to	to	PART
ijpds-3133	150	28	mechanically	mechanically	ADV
ijpds-3133	150	29	push	push	VERB
ijpds-3133	150	30	the	the	DET
ijpds-3133	150	31	loaded	load	VERB
ijpds-3133	150	32	drug	drug	NOUN
ijpds-3133	150	33	out	out	ADP
ijpds-3133	150	34	of	of	ADP
ijpds-3133	150	35	the	the	DET
ijpds-3133	150	36	reservoir	reservoir	NOUN
ijpds-3133	150	37	.	.	PUNCT
ijpds-3133	151	1	the	the	DET
ijpds-3133	151	2	device	device	NOUN
ijpds-3133	151	3	,	,	PUNCT
ijpds-3133	151	4	currently	currently	ADV
ijpds-3133	151	5	in	in	ADP
ijpds-3133	151	6	a	a	DET
ijpds-3133	151	7	preclinical	preclinical	ADJ
ijpds-3133	151	8	development	development	NOUN
ijpds-3133	151	9	phase	phase	NOUN
ijpds-3133	151	10	,	,	PUNCT
ijpds-3133	151	11	also	also	ADV
ijpds-3133	151	12	allows	allow	VERB
ijpds-3133	151	13	loading	load	VERB
ijpds-3133	151	14	the	the	DET
ijpds-3133	151	15	drug	drug	NOUN
ijpds-3133	151	16	multiple	multiple	ADJ
ijpds-3133	151	17	times	time	NOUN
ijpds-3133	151	18	[	[	X
ijpds-3133	151	19	41	41	NUM
ijpds-3133	151	20	]	]	PUNCT
ijpds-3133	151	21	.	.	PUNCT
ijpds-3133	152	1	saati	saati	PROPN
ijpds-3133	152	2	et	et	PROPN
ijpds-3133	152	3	al	al	PROPN
ijpds-3133	152	4	.	.	PROPN
ijpds-3133	152	5	demonstrated	demonstrate	VERB
ijpds-3133	152	6	the	the	DET
ijpds-3133	152	7	use	use	NOUN
ijpds-3133	152	8	of	of	ADP
ijpds-3133	152	9	the	the	DET
ijpds-3133	152	10	mems	mem	NOUN
ijpds-3133	152	11	pumping	pumping	NOUN
ijpds-3133	152	12	mechanism	mechanism	NOUN
ijpds-3133	152	13	was	be	AUX
ijpds-3133	152	14	based	base	VERB
ijpds-3133	152	15	on	on	ADP
ijpds-3133	152	16	electrolysis	electrolysis	NOUN
ijpds-3133	152	17	connected	connect	VERB
ijpds-3133	152	18	to	to	ADP
ijpds-3133	152	19	a	a	DET
ijpds-3133	152	20	drug	drug	NOUN
ijpds-3133	152	21	refill	refill	NOUN
ijpds-3133	152	22	port	port	NOUN
ijpds-3133	152	23	a	a	DET
ijpds-3133	152	24	check	check	NOUN
ijpds-3133	152	25	valve	valve	NOUN
ijpds-3133	152	26	to	to	ADP
ijpds-3133	152	27	control	control	NOUN
ijpds-3133	152	28	delivery	delivery	NOUN
ijpds-3133	152	29	.	.	PUNCT
ijpds-3133	153	1	the	the	DET
ijpds-3133	153	2	procedure	procedure	NOUN
ijpds-3133	153	3	is	be	AUX
ijpds-3133	153	4	similar	similar	ADJ
ijpds-3133	153	5	to	to	ADP
ijpds-3133	153	6	the	the	DET
ijpds-3133	153	7	implantation	implantation	NOUN
ijpds-3133	153	8	of	of	ADP
ijpds-3133	153	9	a	a	DET
ijpds-3133	153	10	glaucoma	glaucoma	NOUN
ijpds-3133	153	11	aqueous	aqueous	ADJ
ijpds-3133	153	12	drainage	drainage	NOUN
ijpds-3133	153	13	device	device	NOUN
ijpds-3133	153	14	.	.	PUNCT
ijpds-3133	154	1	liposomethe	liposomethe	ADJ
ijpds-3133	154	2	liposome	liposome	NOUN
ijpds-3133	154	3	-	-	PUNCT
ijpds-3133	154	4	encapsulated	encapsulate	VERB
ijpds-3133	154	5	drug	drug	NOUN
ijpds-3133	154	6	was	be	AUX
ijpds-3133	154	7	delivered	deliver	VERB
ijpds-3133	154	8	as	as	ADP
ijpds-3133	154	9	a	a	DET
ijpds-3133	154	10	solution	solution	NOUN
ijpds-3133	154	11	as	as	ADP
ijpds-3133	154	12	an	an	DET
ijpds-3133	154	13	eye	eye	NOUN
ijpds-3133	154	14	drop	drop	NOUN
ijpds-3133	154	15	.	.	PUNCT
ijpds-3133	155	1	natarajan	natarajan	PROPN
ijpds-3133	155	2	and	and	CCONJ
ijpds-3133	155	3	colleagues	colleague	NOUN
ijpds-3133	155	4	used	use	VERB
ijpds-3133	155	5	latanoprost	latanoprost	ADV
ijpds-3133	155	6	-	-	PUNCT
ijpds-3133	155	7	loaded	load	VERB
ijpds-3133	155	8	egg	egg	NOUN
ijpds-3133	155	9	-	-	PUNCT
ijpds-3133	155	10	phosphatidylcholine	phosphatidylcholine	NOUN
ijpds-3133	155	11	liposomes	liposome	NOUN
ijpds-3133	155	12	for	for	ADP
ijpds-3133	155	13	delivery	delivery	NOUN
ijpds-3133	155	14	.	.	PUNCT
ijpds-3133	156	1	the	the	DET
ijpds-3133	156	2	liposomes	liposome	NOUN
ijpds-3133	156	3	remained	remain	VERB
ijpds-3133	156	4	stable	stable	ADJ
ijpds-3133	156	5	for	for	ADP
ijpds-3133	156	6	at	at	ADV
ijpds-3133	156	7	least	least	ADV
ijpds-3133	156	8	six	six	NUM
ijpds-3133	156	9	months	month	NOUN
ijpds-3133	156	10	on	on	ADP
ijpds-3133	156	11	storage	storage	NOUN
ijpds-3133	156	12	at	at	ADP
ijpds-3133	156	13	4	4	NUM
ijpds-3133	156	14	°	°	ADP
ijpds-3133	156	15	c	c	NOUN
ijpds-3133	156	16	and	and	CCONJ
ijpds-3133	156	17	at	at	ADV
ijpds-3133	156	18	least	least	ADV
ijpds-3133	156	19	one	one	NUM
ijpds-3133	156	20	month	month	NOUN
ijpds-3133	156	21	at	at	ADP
ijpds-3133	156	22	25	25	NUM
ijpds-3133	156	23	°	°	NOUN
ijpds-3133	156	24	c	c	NOUN
ijpds-3133	156	25	.	.	PUNCT
ijpds-3133	157	1	a	a	DET
ijpds-3133	157	2	sustained	sustained	ADJ
ijpds-3133	157	3	release	release	NOUN
ijpds-3133	157	4	of	of	ADP
ijpds-3133	157	5	60	60	NUM
ijpds-3133	157	6	%	%	NOUN
ijpds-3133	157	7	of	of	ADP
ijpds-3133	157	8	latanoprost	latanoprost	NOUN
ijpds-3133	157	9	was	be	AUX
ijpds-3133	157	10	achieved	achieve	VERB
ijpds-3133	157	11	by	by	ADP
ijpds-3133	157	12	two	two	NUM
ijpds-3133	157	13	weeks	week	NOUN
ijpds-3133	157	14	in	in	ADP
ijpds-3133	157	15	vitro	vitro	X
ijpds-3133	157	16	.	.	PUNCT
ijpds-3133	158	1	a	a	DET
ijpds-3133	158	2	high	high	ADJ
ijpds-3133	158	3	sustained	sustained	ADJ
ijpds-3133	158	4	iop	iop	NOUN
ijpds-3133	158	5	-	-	PUNCT
ijpds-3133	158	6	lowering	lower	VERB
ijpds-3133	158	7	effect	effect	NOUN
ijpds-3133	158	8	was	be	AUX
ijpds-3133	158	9	recorded	record	VERB
ijpds-3133	158	10	in	in	ADP
ijpds-3133	158	11	liposome	liposome	NOUN
ijpds-3133	158	12	-	-	PUNCT
ijpds-3133	158	13	treated	treat	VERB
ijpds-3133	158	14	animals	animal	NOUN
ijpds-3133	158	15	(	(	PUNCT
ijpds-3133	158	16	4.8	4.8	NUM
ijpds-3133	158	17	±	±	NUM
ijpds-3133	158	18	1.5	1.5	NUM
ijpds-3133	158	19	mmhg	mmhg	NOUN
ijpds-3133	158	20	)	)	PUNCT
ijpds-3133	158	21	compared	compare	VERB
ijpds-3133	158	22	with	with	ADP
ijpds-3133	158	23	daily	daily	ADJ
ijpds-3133	158	24	administration	administration	NOUN
ijpds-3133	158	25	of	of	ADP
ijpds-3133	158	26	topical	topical	ADJ
ijpds-3133	158	27	latanoprost	latanoprost	NOUN
ijpds-3133	158	28	(	(	PUNCT
ijpds-3133	158	29	2.5	2.5	NUM
ijpds-3133	158	30	±	±	NUM
ijpds-3133	158	31	0.9	0.9	NUM
ijpds-3133	158	32	mmhg	mmhg	NOUN
ijpds-3133	158	33	)	)	PUNCT
ijpds-3133	158	34	beyond	beyond	ADP
ijpds-3133	158	35	90	90	NUM
ijpds-3133	158	36	days	day	NOUN
ijpds-3133	159	1	[	[	X
ijpds-3133	159	2	42	42	NUM
ijpds-3133	159	3	]	]	PUNCT
ijpds-3133	159	4	.	.	PUNCT
ijpds-3133	160	1	monem	monem	PROPN
ijpds-3133	160	2	and	and	CCONJ
ijpds-3133	160	3	colleagues	colleague	NOUN
ijpds-3133	160	4	used	use	VERB
ijpds-3133	160	5	multilamellar	multilamellar	ADJ
ijpds-3133	160	6	vesicles	vesicle	NOUN
ijpds-3133	160	7	(	(	PUNCT
ijpds-3133	160	8	mlvs	mlvs	NOUN
ijpds-3133	160	9	)	)	PUNCT
ijpds-3133	160	10	as	as	ADP
ijpds-3133	160	11	a	a	DET
ijpds-3133	160	12	vehicle	vehicle	NOUN
ijpds-3133	160	13	for	for	ADP
ijpds-3133	160	14	delivering	deliver	VERB
ijpds-3133	160	15	pilocarpine	pilocarpine	NOUN
ijpds-3133	160	16	.	.	PUNCT
ijpds-3133	161	1	they	they	PRON
ijpds-3133	161	2	reported	report	VERB
ijpds-3133	161	3	neutral	neutral	ADJ
ijpds-3133	161	4	mlvs	mlvs	ADV
ijpds-3133	161	5	encapsulating	encapsulate	VERB
ijpds-3133	161	6	pilocarpine	pilocarpine	NOUN
ijpds-3133	161	7	hcl	hcl	PROPN
ijpds-3133	161	8	exhibited	exhibit	VERB
ijpds-3133	161	9	the	the	DET
ijpds-3133	161	10	most	most	ADV
ijpds-3133	161	11	prolonged	prolonged	ADJ
ijpds-3133	161	12	efficacy	efficacy	NOUN
ijpds-3133	161	13	in	in	ADP
ijpds-3133	161	14	the	the	DET
ijpds-3133	161	15	reduction	reduction	NOUN
ijpds-3133	161	16	of	of	ADP
ijpds-3133	161	17	iop	iop	PROPN
ijpds-3133	161	18	.	.	PUNCT
ijpds-3133	162	1	they	they	PRON
ijpds-3133	162	2	also	also	ADV
ijpds-3133	162	3	reported	report	VERB
ijpds-3133	162	4	negatively	negatively	ADV
ijpds-3133	162	5	charged	charge	VERB
ijpds-3133	162	6	mlvs	mlvs	ADV
ijpds-3133	162	7	encapsulating	encapsulate	VERB
ijpds-3133	162	8	pilocarpine	pilocarpine	NOUN
ijpds-3133	162	9	hcl	hcl	PROPN
ijpds-3133	162	10	exhibited	exhibit	VERB
ijpds-3133	162	11	a	a	DET
ijpds-3133	162	12	significantly	significantly	ADV
ijpds-3133	162	13	shorter	short	ADJ
ijpds-3133	162	14	period	period	NOUN
ijpds-3133	162	15	of	of	ADP
ijpds-3133	162	16	drug	drug	NOUN
ijpds-3133	162	17	action	action	NOUN
ijpds-3133	163	1	[	[	X
ijpds-3133	163	2	43	43	NUM
ijpds-3133	163	3	]	]	PUNCT
ijpds-3133	163	4	.	.	PUNCT
ijpds-3133	164	1	the	the	DET
ijpds-3133	164	2	group	group	NOUN
ijpds-3133	164	3	speculated	speculate	VERB
ijpds-3133	164	4	that	that	SCONJ
ijpds-3133	164	5	the	the	DET
ijpds-3133	164	6	frequency	frequency	NOUN
ijpds-3133	164	7	of	of	ADP
ijpds-3133	164	8	administration	administration	NOUN
ijpds-3133	164	9	of	of	ADP
ijpds-3133	164	10	drug	drug	PROPN
ijpds-3133	164	11	administration	administration	NOUN
ijpds-3133	164	12	in	in	ADP
ijpds-3133	164	13	humans	human	NOUN
ijpds-3133	164	14	would	would	AUX
ijpds-3133	164	15	be	be	AUX
ijpds-3133	164	16	reduced	reduce	VERB
ijpds-3133	164	17	to	to	ADP
ijpds-3133	164	18	half	half	NOUN
ijpds-3133	164	19	with	with	ADP
ijpds-3133	164	20	the	the	DET
ijpds-3133	164	21	usage	usage	NOUN
ijpds-3133	164	22	of	of	ADP
ijpds-3133	164	23	mlv	mlv	ADJ
ijpds-3133	164	24	vehicles	vehicle	NOUN
ijpds-3133	164	25	,	,	PUNCT
ijpds-3133	164	26	thus	thus	ADV
ijpds-3133	164	27	promoting	promote	VERB
ijpds-3133	164	28	better	well	ADJ
ijpds-3133	164	29	compliance	compliance	NOUN
ijpds-3133	164	30	.	.	PUNCT
ijpds-3133	165	1	polymeric	polymeric	ADJ
ijpds-3133	165	2	nanoparticlesdue	nanoparticlesdue	ADV
ijpds-3133	165	3	to	to	ADP
ijpds-3133	165	4	their	their	PRON
ijpds-3133	165	5	molecular	molecular	ADJ
ijpds-3133	165	6	-	-	PUNCT
ijpds-3133	165	7	scale	scale	NOUN
ijpds-3133	165	8	size	size	NOUN
ijpds-3133	165	9	,	,	PUNCT
ijpds-3133	165	10	nanoparticles	nanoparticle	NOUN
ijpds-3133	165	11	efficaciously	efficaciously	ADV
ijpds-3133	165	12	deliver	deliver	VERB
ijpds-3133	165	13	drugs	drug	NOUN
ijpds-3133	165	14	in	in	ADP
ijpds-3133	165	15	the	the	DET
ijpds-3133	165	16	anterior	anterior	ADJ
ijpds-3133	165	17	chamber	chamber	NOUN
ijpds-3133	165	18	in	in	ADP
ijpds-3133	165	19	the	the	DET
ijpds-3133	165	20	posterior	posterior	ADJ
ijpds-3133	165	21	compartment	compartment	NOUN
ijpds-3133	165	22	via	via	ADP
ijpds-3133	165	23	the	the	DET
ijpds-3133	165	24	bloodaqueous	bloodaqueous	ADJ
ijpds-3133	165	25	and	and	CCONJ
ijpds-3133	165	26	the	the	DET
ijpds-3133	165	27	blood	blood	NOUN
ijpds-3133	165	28	-	-	PUNCT
ijpds-3133	165	29	retina	retina	NOUN
ijpds-3133	165	30	barrier	barrier	NOUN
ijpds-3133	165	31	,	,	PUNCT
ijpds-3133	165	32	respectively	respectively	ADV
ijpds-3133	165	33	[	[	X
ijpds-3133	165	34	44	44	NUM
ijpds-3133	165	35	]	]	PUNCT
ijpds-3133	165	36	.	.	PUNCT
ijpds-3133	166	1	different	different	ADJ
ijpds-3133	166	2	types	type	NOUN
ijpds-3133	166	3	of	of	ADP
ijpds-3133	166	4	nanoparticles	nanoparticle	NOUN
ijpds-3133	166	5	were	be	AUX
ijpds-3133	166	6	classified	classify	VERB
ijpds-3133	166	7	based	base	VERB
ijpds-3133	166	8	on	on	ADP
ijpds-3133	166	9	the	the	DET
ijpds-3133	166	10	origin	origin	NOUN
ijpds-3133	166	11	of	of	ADP
ijpds-3133	166	12	the	the	DET
ijpds-3133	166	13	constituent	constituent	NOUN
ijpds-3133	166	14	monomers	monomer	NOUN
ijpds-3133	166	15	and	and	CCONJ
ijpds-3133	166	16	its	its	PRON
ijpds-3133	166	17	emphasis	emphasis	NOUN
ijpds-3133	166	18	was	be	AUX
ijpds-3133	166	19	laid	lay	VERB
ijpds-3133	166	20	on	on	ADP
ijpds-3133	166	21	effective	effective	ADJ
ijpds-3133	166	22	drug	drug	NOUN
ijpds-3133	166	23	loading	loading	NOUN
ijpds-3133	166	24	on	on	ADP
ijpds-3133	166	25	the	the	DET
ijpds-3133	166	26	nanoparticles	nanoparticle	NOUN
ijpds-3133	166	27	through	through	ADP
ijpds-3133	166	28	the	the	DET
ijpds-3133	166	29	process	process	NOUN
ijpds-3133	166	30	such	such	ADJ
ijpds-3133	166	31	as	as	ADP
ijpds-3133	166	32	electrospraying	electrospraye	VERB
ijpds-3133	166	33	and	and	CCONJ
ijpds-3133	166	34	electrospinning	electrospinne	VERB
ijpds-3133	166	35	.	.	PUNCT
ijpds-3133	167	1	mehta	mehta	PROPN
ijpds-3133	167	2	et	et	PROPN
ijpds-3133	167	3	al	al	PROPN
ijpds-3133	167	4	.	.	PROPN
ijpds-3133	167	5	demonstrated	demonstrate	VERB
ijpds-3133	167	6	a	a	DET
ijpds-3133	167	7	single	single	ADJ
ijpds-3133	167	8	-	-	PUNCT
ijpds-3133	167	9	needle	needle	NOUN
ijpds-3133	167	10	electrohydrodynamic	electrohydrodynamic	ADJ
ijpds-3133	167	11	process	process	NOUN
ijpds-3133	167	12	for	for	ADP
ijpds-3133	167	13	adding	add	VERB
ijpds-3133	167	14	a	a	DET
ijpds-3133	167	15	stable	stable	ADJ
ijpds-3133	167	16	nanocoating	nanocoating	NOUN
ijpds-3133	167	17	to	to	ADP
ijpds-3133	167	18	the	the	DET
ijpds-3133	167	19	contact	contact	NOUN
ijpds-3133	167	20	lenses	lense	NOUN
ijpds-3133	167	21	with	with	ADP
ijpds-3133	167	22	timolol	timolol	NOUN
ijpds-3133	167	23	maleate	maleate	NOUN
ijpds-3133	167	24	.	.	PUNCT
ijpds-3133	168	1	the	the	DET
ijpds-3133	168	2	in	in	ADP
ijpds-3133	168	3	vitro	vitro	X
ijpds-3133	168	4	studies	study	NOUN
ijpds-3133	168	5	showed	show	VERB
ijpds-3133	168	6	biphasic	biphasic	ADJ
ijpds-3133	168	7	release	release	NOUN
ijpds-3133	168	8	of	of	ADP
ijpds-3133	168	9	the	the	DET
ijpds-3133	168	10	drug	drug	NOUN
ijpds-3133	168	11	,	,	PUNCT
ijpds-3133	168	12	with	with	ADP
ijpds-3133	168	13	an	an	DET
ijpds-3133	168	14	initial	initial	ADJ
ijpds-3133	168	15	burst	burst	ADJ
ijpds-3133	168	16	release	release	NOUN
ijpds-3133	168	17	followed	follow	VERB
ijpds-3133	168	18	by	by	ADP
ijpds-3133	168	19	sustained	sustained	ADJ
ijpds-3133	168	20	release	release	NOUN
ijpds-3133	168	21	[	[	X
ijpds-3133	168	22	45	45	NUM
ijpds-3133	168	23	]	]	PUNCT
ijpds-3133	168	24	.	.	PUNCT
ijpds-3133	169	1	chitosan	chitosan	NOUN
ijpds-3133	169	2	-	-	PUNCT
ijpds-3133	169	3	based	base	VERB
ijpds-3133	169	4	polymeric	polymeric	ADJ
ijpds-3133	169	5	nanoparticleschitosan	nanoparticleschitosan	NOUN
ijpds-3133	169	6	,	,	PUNCT
ijpds-3133	169	7	a	a	DET
ijpds-3133	169	8	2amino-2	2amino-2	NUM
ijpds-3133	169	9	-	-	PUNCT
ijpds-3133	169	10	deoxy	deoxy	ADJ
ijpds-3133	169	11	-	-	PUNCT
ijpds-3133	169	12	beta	beta	NOUN
ijpds-3133	169	13	-	-	PUNCT
ijpds-3133	169	14	d	d	NOUN
ijpds-3133	169	15	-	-	PUNCT
ijpds-3133	169	16	glucan	glucan	NOUN
ijpds-3133	169	17	,	,	PUNCT
ijpds-3133	169	18	is	be	AUX
ijpds-3133	169	19	being	be	AUX
ijpds-3133	169	20	widely	widely	ADV
ijpds-3133	169	21	tested	test	VERB
ijpds-3133	169	22	for	for	ADP
ijpds-3133	169	23	rai	rai	X
ijpds-3133	169	24	et	et	PROPN
ijpds-3133	169	25	al	al	PROPN
ijpds-3133	169	26	mindful	mindful	ADJ
ijpds-3133	169	27	-	-	PUNCT
ijpds-3133	169	28	based	base	VERB
ijpds-3133	169	29	stress	stress	NOUN
ijpds-3133	169	30	reduction	reduction	NOUN
ijpds-3133	169	31	impact	impact	NOUN
ijpds-3133	169	32	vol	vol	NOUN
ijpds-3133	169	33	1	1	NUM
ijpds-3133	169	34	|	|	NOUN
ijpds-3133	169	35	issue	issue	NOUN
ijpds-3133	169	36	2	2	NUM
ijpds-3133	169	37	|	|	ADV
ijpds-3133	169	38	jul	jul	PROPN
ijpds-3133	169	39	–	–	PUNCT
ijpds-3133	169	40	sep	sep	PROPN
ijpds-3133	169	41	2022	2022	NUM
ijpds-3133	170	1	indian	indian	PROPN
ijpds-3133	170	2	j	j	PROPN
ijpds-3133	170	3	pharm	pharm	PROPN
ijpds-3133	170	4	drug	drug	PROPN
ijpds-3133	170	5	studies	study	NOUN
ijpds-3133	170	6	|	|	ADV
ijpds-3133	170	7	42	42	NUM
ijpds-3133	170	8	synthesizing	synthesize	VERB
ijpds-3133	170	9	nanoparticles	nanoparticle	NOUN
ijpds-3133	170	10	for	for	ADP
ijpds-3133	170	11	drug	drug	NOUN
ijpds-3133	170	12	delivery	delivery	NOUN
ijpds-3133	170	13	[	[	X
ijpds-3133	170	14	46	46	NUM
ijpds-3133	170	15	]	]	PUNCT
ijpds-3133	170	16	.	.	PUNCT
ijpds-3133	171	1	the	the	DET
ijpds-3133	171	2	biodegradable	biodegradable	ADJ
ijpds-3133	171	3	,	,	PUNCT
ijpds-3133	171	4	biocompatible	biocompatible	ADJ
ijpds-3133	171	5	,	,	PUNCT
ijpds-3133	171	6	and	and	CCONJ
ijpds-3133	171	7	mucoadhesive	mucoadhesive	ADJ
ijpds-3133	171	8	properties	property	NOUN
ijpds-3133	171	9	of	of	ADP
ijpds-3133	171	10	chitosan	chitosan	NOUN
ijpds-3133	171	11	make	make	VERB
ijpds-3133	171	12	it	it	PRON
ijpds-3133	171	13	highly	highly	ADV
ijpds-3133	171	14	suitable	suitable	ADJ
ijpds-3133	171	15	for	for	ADP
ijpds-3133	171	16	delivering	deliver	VERB
ijpds-3133	171	17	antiglaucoma	antiglaucoma	NOUN
ijpds-3133	171	18	drugs	drug	NOUN
ijpds-3133	171	19	.	.	PUNCT
ijpds-3133	172	1	li	li	PROPN
ijpds-3133	172	2	and	and	CCONJ
ijpds-3133	172	3	colleagues	colleague	NOUN
ijpds-3133	173	1	[	[	X
ijpds-3133	173	2	47	47	NUM
ijpds-3133	173	3	]	]	PUNCT
ijpds-3133	173	4	developed	develop	VERB
ijpds-3133	173	5	chitosan	chitosan	NOUN
ijpds-3133	173	6	nanoparticles	nanoparticle	NOUN
ijpds-3133	173	7	loaded	load	VERB
ijpds-3133	173	8	with	with	ADP
ijpds-3133	173	9	beta	beta	NOUN
ijpds-3133	173	10	-	-	PUNCT
ijpds-3133	173	11	adrenergic	adrenergic	ADJ
ijpds-3133	173	12	agent	agent	NOUN
ijpds-3133	173	13	betaxolol	betaxolol	NOUN
ijpds-3133	173	14	,	,	PUNCT
ijpds-3133	173	15	prescribed	prescribe	VERB
ijpds-3133	173	16	for	for	ADP
ijpds-3133	173	17	lower	low	ADJ
ijpds-3133	173	18	iop	iop	NOUN
ijpds-3133	173	19	.	.	PUNCT
ijpds-3133	174	1	the	the	DET
ijpds-3133	174	2	ex	ex	X
ijpds-3133	174	3	vivo	vivo	NOUN
ijpds-3133	174	4	data	datum	NOUN
ijpds-3133	174	5	published	publish	VERB
ijpds-3133	174	6	by	by	ADP
ijpds-3133	174	7	the	the	DET
ijpds-3133	174	8	authors	author	NOUN
ijpds-3133	174	9	show	show	VERB
ijpds-3133	174	10	a	a	DET
ijpds-3133	174	11	1.75	1.75	NUM
ijpds-3133	174	12	times	time	NOUN
ijpds-3133	174	13	higher	high	ADJ
ijpds-3133	174	14	value	value	NOUN
ijpds-3133	174	15	compared	compare	VERB
ijpds-3133	174	16	with	with	ADP
ijpds-3133	174	17	the	the	DET
ijpds-3133	174	18	topical	topical	ADJ
ijpds-3133	174	19	eye	eye	NOUN
ijpds-3133	174	20	drops	drop	NOUN
ijpds-3133	174	21	.	.	PUNCT
ijpds-3133	175	1	zhao	zhao	NOUN
ijpds-3133	175	2	and	and	CCONJ
ijpds-3133	175	3	colleagues	colleague	NOUN
ijpds-3133	176	1	[	[	X
ijpds-3133	176	2	49	49	NUM
ijpds-3133	176	3	]	]	PUNCT
ijpds-3133	176	4	have	have	AUX
ijpds-3133	176	5	developed	develop	VERB
ijpds-3133	176	6	timolol	timolol	NOUN
ijpds-3133	176	7	maleate	maleate	NOUN
ijpds-3133	176	8	–	–	PUNCT
ijpds-3133	176	9	loaded	load	VERB
ijpds-3133	176	10	nanoparticles	nanoparticle	NOUN
ijpds-3133	176	11	from	from	ADP
ijpds-3133	176	12	glycosylated	glycosylated	ADJ
ijpds-3133	176	13	polymers	polymer	NOUN
ijpds-3133	176	14	of	of	ADP
ijpds-3133	176	15	chitosan	chitosan	NOUN
ijpds-3133	176	16	for	for	ADP
ijpds-3133	176	17	ocular	ocular	ADJ
ijpds-3133	176	18	delivery	delivery	NOUN
ijpds-3133	176	19	.	.	PUNCT
ijpds-3133	177	1	the	the	DET
ijpds-3133	177	2	authors	author	NOUN
ijpds-3133	177	3	reported	report	VERB
ijpds-3133	177	4	an	an	DET
ijpds-3133	177	5	augmented	augment	VERB
ijpds-3133	177	6	transcorneal	transcorneal	NOUN
ijpds-3133	177	7	penetration	penetration	NOUN
ijpds-3133	177	8	due	due	ADP
ijpds-3133	177	9	to	to	ADP
ijpds-3133	177	10	high	high	ADJ
ijpds-3133	177	11	lipid	lipid	NOUN
ijpds-3133	177	12	solubility	solubility	NOUN
ijpds-3133	177	13	.	.	PUNCT
ijpds-3133	178	1	the	the	DET
ijpds-3133	178	2	authors	author	NOUN
ijpds-3133	178	3	reported	report	VERB
ijpds-3133	178	4	that	that	SCONJ
ijpds-3133	178	5	the	the	DET
ijpds-3133	178	6	data	datum	NOUN
ijpds-3133	178	7	from	from	ADP
ijpds-3133	178	8	the	the	DET
ijpds-3133	178	9	in	in	ADP
ijpds-3133	178	10	vivo	vivo	ADJ
ijpds-3133	178	11	experiments	experiment	NOUN
ijpds-3133	178	12	showed	show	VERB
ijpds-3133	178	13	a	a	DET
ijpds-3133	178	14	sustained	sustained	ADJ
ijpds-3133	178	15	release	release	NOUN
ijpds-3133	178	16	over	over	ADP
ijpds-3133	178	17	a	a	DET
ijpds-3133	178	18	significantly	significantly	ADV
ijpds-3133	178	19	longer	long	ADJ
ijpds-3133	178	20	duration	duration	NOUN
ijpds-3133	178	21	of	of	ADP
ijpds-3133	178	22	time	time	NOUN
ijpds-3133	178	23	.	.	PUNCT
ijpds-3133	179	1	mehta	mehta	PROPN
ijpds-3133	179	2	et	et	PROPN
ijpds-3133	179	3	al	al	PROPN
ijpds-3133	179	4	.	.	PROPN
ijpds-3133	179	5	used	use	VERB
ijpds-3133	179	6	electrohydrodynamic	electrohydrodynamic	ADJ
ijpds-3133	179	7	atomization	atomization	NOUN
ijpds-3133	179	8	of	of	ADP
ijpds-3133	179	9	timolol	timolol	NOUN
ijpds-3133	179	10	maleate	maleate	NOUN
ijpds-3133	179	11	–	–	PUNCT
ijpds-3133	179	12	loaded	load	VERB
ijpds-3133	179	13	pvp	pvp	NOUN
ijpds-3133	179	14	and	and	CCONJ
ijpds-3133	179	15	poly	poly	ADJ
ijpds-3133	179	16	(	(	PUNCT
ijpds-3133	179	17	n	n	CCONJ
ijpds-3133	179	18	-	-	PUNCT
ijpds-3133	179	19	isopropyl	isopropyl	NOUN
ijpds-3133	179	20	acrylamide	acrylamide	NOUN
ijpds-3133	179	21	)	)	PUNCT
ijpds-3133	179	22	.	.	PUNCT
ijpds-3133	180	1	the	the	DET
ijpds-3133	180	2	authors	author	NOUN
ijpds-3133	180	3	used	use	VERB
ijpds-3133	180	4	the	the	DET
ijpds-3133	180	5	formulation	formulation	NOUN
ijpds-3133	180	6	approach	approach	NOUN
ijpds-3133	180	7	for	for	ADP
ijpds-3133	180	8	sustained	sustained	ADJ
ijpds-3133	180	9	timolol	timolol	NOUN
ijpds-3133	180	10	maleate	maleate	NOUN
ijpds-3133	180	11	release	release	NOUN
ijpds-3133	180	12	used	use	VERB
ijpds-3133	180	13	the	the	DET
ijpds-3133	180	14	combination	combination	NOUN
ijpds-3133	180	15	of	of	ADP
ijpds-3133	180	16	chitosan	chitosan	NOUN
ijpds-3133	180	17	,	,	PUNCT
ijpds-3133	180	18	borneol	borneol	NOUN
ijpds-3133	180	19	and	and	CCONJ
ijpds-3133	180	20	reported	report	VERB
ijpds-3133	180	21	the	the	DET
ijpds-3133	180	22	biphasic	biphasic	ADJ
ijpds-3133	180	23	and	and	CCONJ
ijpds-3133	180	24	triphasic	triphasic	ADJ
ijpds-3133	180	25	release	release	NOUN
ijpds-3133	180	26	,	,	PUNCT
ijpds-3133	180	27	depending	depend	VERB
ijpds-3133	180	28	on	on	ADP
ijpds-3133	180	29	composition	composition	NOUN
ijpds-3133	180	30	[	[	X
ijpds-3133	180	31	49	49	NUM
ijpds-3133	180	32	]	]	PUNCT
ijpds-3133	180	33	.	.	PUNCT
ijpds-3133	181	1	poly	poly	ADJ
ijpds-3133	181	2	(	(	PUNCT
ijpds-3133	181	3	lactic	lactic	NOUN
ijpds-3133	181	4	-	-	PUNCT
ijpds-3133	181	5	co	co	NOUN
ijpds-3133	181	6	-	-	ADJ
ijpds-3133	181	7	glycolic	glycolic	ADJ
ijpds-3133	181	8	acid	acid	NOUN
ijpds-3133	181	9	)	)	PUNCT
ijpds-3133	181	10	nanoparticlesplga	nanoparticlesplga	NOUN
ijpds-3133	181	11	is	be	AUX
ijpds-3133	181	12	a	a	DET
ijpds-3133	181	13	copolymer	copolymer	NOUN
ijpds-3133	181	14	of	of	ADP
ijpds-3133	181	15	cyclic	cyclic	ADJ
ijpds-3133	181	16	dimers	dimer	NOUN
ijpds-3133	181	17	(	(	PUNCT
ijpds-3133	181	18	1	1	NUM
ijpds-3133	181	19	,	,	PUNCT
ijpds-3133	181	20	4	4	NUM
ijpds-3133	181	21	-	-	SYM
ijpds-3133	181	22	dioxane-2	dioxane-2	NUM
ijpds-3133	181	23	,	,	PUNCT
ijpds-3133	181	24	5	5	NUM
ijpds-3133	181	25	-	-	PUNCT
ijpds-3133	181	26	diones	dione	NOUN
ijpds-3133	181	27	)	)	PUNCT
ijpds-3133	181	28	of	of	ADP
ijpds-3133	181	29	glycolic	glycolic	NOUN
ijpds-3133	181	30	acid	acid	NOUN
ijpds-3133	181	31	and	and	CCONJ
ijpds-3133	181	32	lactic	lactic	ADJ
ijpds-3133	181	33	acid	acid	NOUN
ijpds-3133	181	34	[	[	X
ijpds-3133	181	35	50	50	NUM
ijpds-3133	181	36	]	]	PUNCT
ijpds-3133	181	37	.	.	PUNCT
ijpds-3133	182	1	salama	salama	NOUN
ijpds-3133	182	2	and	and	CCONJ
ijpds-3133	182	3	colleagues	colleague	NOUN
ijpds-3133	182	4	[	[	X
ijpds-3133	182	5	51	51	NUM
ijpds-3133	182	6	]	]	PUNCT
ijpds-3133	182	7	used	use	VERB
ijpds-3133	182	8	plga	plga	NOUN
ijpds-3133	182	9	nanoparticles	nanoparticle	NOUN
ijpds-3133	182	10	for	for	ADP
ijpds-3133	182	11	the	the	DET
ijpds-3133	182	12	delivery	delivery	NOUN
ijpds-3133	182	13	of	of	ADP
ijpds-3133	182	14	brinzolamide	brinzolamide	NOUN
ijpds-3133	182	15	subconjunctivally	subconjunctivally	ADV
ijpds-3133	182	16	and	and	CCONJ
ijpds-3133	182	17	reported	report	VERB
ijpds-3133	182	18	the	the	DET
ijpds-3133	182	19	release	release	NOUN
ijpds-3133	182	20	of	of	ADP
ijpds-3133	182	21	the	the	DET
ijpds-3133	182	22	drug	drug	NOUN
ijpds-3133	182	23	was	be	AUX
ijpds-3133	182	24	prolonged	prolong	VERB
ijpds-3133	182	25	for	for	ADP
ijpds-3133	182	26	a	a	DET
ijpds-3133	182	27	period	period	NOUN
ijpds-3133	182	28	of	of	ADP
ijpds-3133	182	29	up	up	ADP
ijpds-3133	182	30	to	to	PART
ijpds-3133	182	31	10	10	NUM
ijpds-3133	182	32	days	day	NOUN
ijpds-3133	182	33	after	after	ADP
ijpds-3133	182	34	a	a	DET
ijpds-3133	182	35	single	single	ADJ
ijpds-3133	182	36	dosage	dosage	NOUN
ijpds-3133	182	37	.	.	PUNCT
ijpds-3133	183	1	khan	khan	PROPN
ijpds-3133	183	2	and	and	CCONJ
ijpds-3133	183	3	colleagues	colleague	NOUN
ijpds-3133	183	4	used	use	VERB
ijpds-3133	183	5	plga	plga	NOUN
ijpds-3133	183	6	-	-	PUNCT
ijpds-3133	183	7	based	base	VERB
ijpds-3133	183	8	nanoparticles	nanoparticle	NOUN
ijpds-3133	183	9	for	for	ADP
ijpds-3133	183	10	the	the	DET
ijpds-3133	183	11	delivery	delivery	NOUN
ijpds-3133	183	12	of	of	ADP
ijpds-3133	183	13	forskolin	forskolin	NOUN
ijpds-3133	183	14	,	,	PUNCT
ijpds-3133	183	15	a	a	DET
ijpds-3133	183	16	natural	natural	ADJ
ijpds-3133	183	17	extract	extract	NOUN
ijpds-3133	183	18	with	with	ADP
ijpds-3133	183	19	potent	potent	ADJ
ijpds-3133	183	20	noradrenergic	noradrenergic	ADJ
ijpds-3133	183	21	stimulatory	stimulatory	ADJ
ijpds-3133	183	22	action	action	NOUN
ijpds-3133	183	23	on	on	ADP
ijpds-3133	183	24	adenylate	adenylate	ADJ
ijpds-3133	183	25	cyclase	cyclase	NOUN
ijpds-3133	183	26	[	[	X
ijpds-3133	183	27	52	52	NUM
ijpds-3133	183	28	,	,	PUNCT
ijpds-3133	183	29	53	53	NUM
ijpds-3133	183	30	]	]	PUNCT
ijpds-3133	183	31	.	.	PUNCT
ijpds-3133	184	1	the	the	DET
ijpds-3133	184	2	authors	author	NOUN
ijpds-3133	184	3	reported	report	VERB
ijpds-3133	184	4	a	a	DET
ijpds-3133	184	5	steady	steady	ADJ
ijpds-3133	184	6	release	release	NOUN
ijpds-3133	184	7	of	of	ADP
ijpds-3133	184	8	the	the	DET
ijpds-3133	184	9	drug	drug	NOUN
ijpds-3133	184	10	from	from	ADP
ijpds-3133	184	11	the	the	DET
ijpds-3133	184	12	plga	plga	NOUN
ijpds-3133	184	13	polymer	polymer	NOUN
ijpds-3133	184	14	,	,	PUNCT
ijpds-3133	184	15	with	with	ADP
ijpds-3133	184	16	90	90	NUM
ijpds-3133	184	17	%	%	NOUN
ijpds-3133	184	18	release	release	NOUN
ijpds-3133	184	19	over	over	ADP
ijpds-3133	184	20	72	72	NUM
ijpds-3133	184	21	h	h	NOUN
ijpds-3133	184	22	compared	compare	VERB
ijpds-3133	184	23	with	with	ADP
ijpds-3133	184	24	eye	eye	NOUN
ijpds-3133	184	25	drops	drop	NOUN
ijpds-3133	184	26	(	(	PUNCT
ijpds-3133	184	27	96.6	96.6	NUM
ijpds-3133	184	28	%	%	NOUN
ijpds-3133	184	29	release	release	NOUN
ijpds-3133	184	30	in	in	ADP
ijpds-3133	184	31	12	12	NUM
ijpds-3133	184	32	h	h	NOUN
ijpds-3133	184	33	)	)	PUNCT
ijpds-3133	184	34	.	.	PUNCT
ijpds-3133	185	1	gelatin	gelatin	NOUN
ijpds-3133	185	2	nanoparticlesthe	nanoparticlesthe	ADJ
ijpds-3133	185	3	ease	ease	NOUN
ijpds-3133	185	4	of	of	ADP
ijpds-3133	185	5	availability	availability	NOUN
ijpds-3133	185	6	and	and	CCONJ
ijpds-3133	185	7	high	high	ADJ
ijpds-3133	185	8	biocompatibility	biocompatibility	NOUN
ijpds-3133	185	9	make	make	VERB
ijpds-3133	185	10	gelatin	gelatin	NOUN
ijpds-3133	185	11	a	a	DET
ijpds-3133	185	12	favorable	favorable	ADJ
ijpds-3133	185	13	polymeric	polymeric	ADJ
ijpds-3133	185	14	vehicle	vehicle	NOUN
ijpds-3133	185	15	for	for	ADP
ijpds-3133	185	16	the	the	DET
ijpds-3133	185	17	delivery	delivery	NOUN
ijpds-3133	185	18	of	of	ADP
ijpds-3133	185	19	antiglaucoma	antiglaucoma	NOUN
ijpds-3133	185	20	drugs	drug	NOUN
ijpds-3133	185	21	to	to	ADP
ijpds-3133	185	22	the	the	DET
ijpds-3133	185	23	eye	eye	NOUN
ijpds-3133	185	24	.	.	PUNCT
ijpds-3133	186	1	recently	recently	ADV
ijpds-3133	186	2	,	,	PUNCT
ijpds-3133	186	3	shokry	shokry	NOUN
ijpds-3133	186	4	and	and	CCONJ
ijpds-3133	186	5	colleagues	colleague	NOUN
ijpds-3133	186	6	reported	report	VERB
ijpds-3133	186	7	the	the	DET
ijpds-3133	186	8	use	use	NOUN
ijpds-3133	186	9	of	of	ADP
ijpds-3133	186	10	gelatin	gelatin	NOUN
ijpds-3133	186	11	nanoparticles	nanoparticle	NOUN
ijpds-3133	186	12	for	for	ADP
ijpds-3133	186	13	delivering	deliver	VERB
ijpds-3133	186	14	timolol	timolol	NOUN
ijpds-3133	186	15	maleate	maleate	NOUN
ijpds-3133	186	16	and	and	CCONJ
ijpds-3133	186	17	reported	report	VERB
ijpds-3133	186	18	increased	increase	VERB
ijpds-3133	186	19	mucoadhesion	mucoadhesion	NOUN
ijpds-3133	186	20	and	and	CCONJ
ijpds-3133	186	21	transcorneal	transcorneal	NOUN
ijpds-3133	186	22	permeability	permeability	NOUN
ijpds-3133	186	23	due	due	ADP
ijpds-3133	186	24	to	to	ADP
ijpds-3133	186	25	its	its	PRON
ijpds-3133	186	26	positive	positive	ADJ
ijpds-3133	186	27	charge	charge	NOUN
ijpds-3133	186	28	attracted	attract	VERB
ijpds-3133	186	29	to	to	PART
ijpds-3133	186	30	negatively	negatively	ADV
ijpds-3133	186	31	charged	charge	VERB
ijpds-3133	186	32	lipid	lipid	NOUN
ijpds-3133	186	33	layers	layer	NOUN
ijpds-3133	186	34	in	in	ADP
ijpds-3133	186	35	the	the	DET
ijpds-3133	186	36	cornea	cornea	NOUN
ijpds-3133	187	1	[	[	X
ijpds-3133	187	2	54	54	NUM
ijpds-3133	187	3	]	]	PUNCT
ijpds-3133	187	4	.	.	PUNCT
ijpds-3133	188	1	the	the	DET
ijpds-3133	188	2	in	in	ADV
ijpds-3133	188	3	vitro	vitro	X
ijpds-3133	188	4	release	release	NOUN
ijpds-3133	188	5	studies	study	NOUN
ijpds-3133	188	6	showed	show	VERB
ijpds-3133	188	7	a	a	DET
ijpds-3133	188	8	burst	burst	ADJ
ijpds-3133	188	9	effect	effect	NOUN
ijpds-3133	188	10	of	of	ADP
ijpds-3133	188	11	timolol	timolol	NOUN
ijpds-3133	188	12	release	release	NOUN
ijpds-3133	188	13	followed	follow	VERB
ijpds-3133	188	14	by	by	ADP
ijpds-3133	188	15	a	a	DET
ijpds-3133	188	16	sustained	sustained	ADJ
ijpds-3133	188	17	profile	profile	NOUN
ijpds-3133	188	18	over	over	ADP
ijpds-3133	188	19	a	a	DET
ijpds-3133	188	20	prolonged	prolonged	ADJ
ijpds-3133	188	21	duration	duration	NOUN
ijpds-3133	188	22	.	.	PUNCT
ijpds-3133	189	1	the	the	DET
ijpds-3133	189	2	in	in	ADP
ijpds-3133	189	3	vivo	vivo	ADJ
ijpds-3133	189	4	studies	study	NOUN
ijpds-3133	189	5	in	in	ADP
ijpds-3133	189	6	the	the	DET
ijpds-3133	189	7	albino	albino	NOUN
ijpds-3133	189	8	rabbits	rabbit	NOUN
ijpds-3133	189	9	showed	show	VERB
ijpds-3133	189	10	a	a	DET
ijpds-3133	189	11	sustained	sustained	ADJ
ijpds-3133	189	12	and	and	CCONJ
ijpds-3133	189	13	higher	high	ADJ
ijpds-3133	189	14	efficacy	efficacy	NOUN
ijpds-3133	189	15	in	in	ADP
ijpds-3133	189	16	iop	iop	NOUN
ijpds-3133	189	17	lowering	lower	VERB
ijpds-3133	189	18	.	.	PUNCT
ijpds-3133	190	1	in	in	ADP
ijpds-3133	190	2	another	another	DET
ijpds-3133	190	3	study	study	NOUN
ijpds-3133	190	4	,	,	PUNCT
ijpds-3133	190	5	liao	liao	PROPN
ijpds-3133	190	6	et	et	PROPN
ijpds-3133	190	7	al	al	PROPN
ijpds-3133	190	8	.	.	PUNCT
ijpds-3133	191	1	[	[	X
ijpds-3133	191	2	55	55	NUM
ijpds-3133	191	3	]	]	PUNCT
ijpds-3133	191	4	used	use	VERB
ijpds-3133	191	5	silica	silica	NOUN
ijpds-3133	191	6	-	-	PUNCT
ijpds-3133	191	7	based	base	VERB
ijpds-3133	191	8	mesoporous	mesoporous	ADJ
ijpds-3133	191	9	nanoparticles	nanoparticle	NOUN
ijpds-3133	191	10	for	for	ADP
ijpds-3133	191	11	pilocarpine	pilocarpine	NOUN
ijpds-3133	191	12	with	with	ADP
ijpds-3133	191	13	gelatin	gelatin	NOUN
ijpds-3133	191	14	coating	coating	NOUN
ijpds-3133	191	15	.	.	PUNCT
ijpds-3133	192	1	the	the	DET
ijpds-3133	192	2	in	in	ADP
ijpds-3133	192	3	vitro	vitro	X
ijpds-3133	192	4	data	datum	NOUN
ijpds-3133	192	5	showed	show	VERB
ijpds-3133	192	6	a	a	DET
ijpds-3133	192	7	36	36	NUM
ijpds-3133	192	8	-	-	PUNCT
ijpds-3133	192	9	day	day	NOUN
ijpds-3133	192	10	release	release	NOUN
ijpds-3133	192	11	profile	profile	NOUN
ijpds-3133	192	12	of	of	ADP
ijpds-3133	192	13	the	the	DET
ijpds-3133	192	14	gelatin	gelatin	NOUN
ijpds-3133	192	15	-	-	PUNCT
ijpds-3133	192	16	coated	coat	VERB
ijpds-3133	192	17	mesoporous	mesoporous	ADJ
ijpds-3133	192	18	nanoparticles	nanoparticle	NOUN
ijpds-3133	192	19	with	with	ADP
ijpds-3133	192	20	an	an	DET
ijpds-3133	192	21	efficacious	efficacious	ADJ
ijpds-3133	192	22	in	in	ADP
ijpds-3133	192	23	vivo	vivo	ADJ
ijpds-3133	192	24	ioplowering	ioplowering	NOUN
ijpds-3133	192	25	effect	effect	NOUN
ijpds-3133	192	26	for	for	ADP
ijpds-3133	192	27	21	21	NUM
ijpds-3133	192	28	days	day	NOUN
ijpds-3133	192	29	.	.	PUNCT
ijpds-3133	193	1	propoxylated	propoxylate	VERB
ijpds-3133	193	2	glyceryl	glyceryl	NOUN
ijpds-3133	193	3	triacylate	triacylate	NOUN
ijpds-3133	193	4	nanoparticlesjung	nanoparticlesjung	PROPN
ijpds-3133	193	5	et	et	PROPN
ijpds-3133	193	6	al	al	PROPN
ijpds-3133	193	7	.	.	PUNCT
ijpds-3133	194	1	[	[	X
ijpds-3133	194	2	56	56	NUM
ijpds-3133	194	3	]	]	PUNCT
ijpds-3133	194	4	developed	develop	VERB
ijpds-3133	194	5	a	a	DET
ijpds-3133	194	6	contact	contact	NOUN
ijpds-3133	194	7	lens	lens	NOUN
ijpds-3133	194	8	based	base	VERB
ijpds-3133	194	9	on	on	ADP
ijpds-3133	194	10	the	the	DET
ijpds-3133	194	11	principle	principle	NOUN
ijpds-3133	194	12	of	of	ADP
ijpds-3133	194	13	dispersing	disperse	VERB
ijpds-3133	194	14	timolol	timolol	NOUN
ijpds-3133	194	15	-	-	PUNCT
ijpds-3133	194	16	loaded	load	VERB
ijpds-3133	194	17	propoxylated	propoxylate	VERB
ijpds-3133	194	18	glyceryl	glyceryl	NOUN
ijpds-3133	194	19	triacylate	triacylate	NOUN
ijpds-3133	194	20	(	(	PUNCT
ijpds-3133	194	21	pgt	pgt	PROPN
ijpds-3133	194	22	)	)	PUNCT
ijpds-3133	194	23	nanoparticles	nanoparticle	NOUN
ijpds-3133	194	24	within	within	ADP
ijpds-3133	194	25	the	the	DET
ijpds-3133	194	26	lens	len	NOUN
ijpds-3133	194	27	.	.	PUNCT
ijpds-3133	195	1	timolol	timolol	PROPN
ijpds-3133	195	2	–	–	PUNCT
ijpds-3133	195	3	pgt	pgt	PROPN
ijpds-3133	195	4	particles	particle	NOUN
ijpds-3133	195	5	release	release	VERB
ijpds-3133	195	6	the	the	DET
ijpds-3133	195	7	drug	drug	NOUN
ijpds-3133	195	8	for	for	ADP
ijpds-3133	195	9	an	an	DET
ijpds-3133	195	10	extended	extended	ADJ
ijpds-3133	195	11	period	period	NOUN
ijpds-3133	195	12	(	(	PUNCT
ijpds-3133	195	13	>	>	SYM
ijpds-3133	195	14	30	30	NUM
ijpds-3133	195	15	days	day	NOUN
ijpds-3133	195	16	at	at	ADP
ijpds-3133	195	17	room	room	NOUN
ijpds-3133	195	18	temperature	temperature	NOUN
ijpds-3133	195	19	)	)	PUNCT
ijpds-3133	195	20	by	by	ADP
ijpds-3133	195	21	hydrolysis	hydrolysis	NOUN
ijpds-3133	195	22	of	of	ADP
ijpds-3133	195	23	the	the	DET
ijpds-3133	195	24	ester	ester	NOUN
ijpds-3133	195	25	bond	bond	NOUN
ijpds-3133	195	26	.	.	PUNCT
ijpds-3133	196	1	the	the	DET
ijpds-3133	196	2	bioavailability	bioavailability	NOUN
ijpds-3133	196	3	of	of	ADP
ijpds-3133	196	4	timolol	timolol	NOUN
ijpds-3133	196	5	delivered	deliver	VERB
ijpds-3133	196	6	through	through	ADP
ijpds-3133	196	7	the	the	DET
ijpds-3133	196	8	contact	contact	NOUN
ijpds-3133	196	9	lens	lens	NOUN
ijpds-3133	196	10	showed	show	VERB
ijpds-3133	196	11	50	50	NUM
ijpds-3133	196	12	%	%	NOUN
ijpds-3133	196	13	bioavailability	bioavailability	NOUN
ijpds-3133	196	14	as	as	SCONJ
ijpds-3133	196	15	compared	compare	VERB
ijpds-3133	196	16	with	with	ADP
ijpds-3133	196	17	only	only	ADV
ijpds-3133	196	18	1–2	1–2	NUM
ijpds-3133	196	19	%	%	NOUN
ijpds-3133	196	20	through	through	ADP
ijpds-3133	196	21	eye	eye	NOUN
ijpds-3133	196	22	drops	drop	NOUN
ijpds-3133	196	23	.	.	PUNCT
ijpds-3133	197	1	pgt	pgt	PROPN
ijpds-3133	197	2	–	–	PUNCT
ijpds-3133	197	3	ethylene	ethylene	NOUN
ijpds-3133	197	4	glycol	glycol	NOUN
ijpds-3133	197	5	dimethacrylate	dimethacrylate	NOUN
ijpds-3133	197	6	nanoparticlesjung	nanoparticlesjung	NOUN
ijpds-3133	197	7	and	and	CCONJ
ijpds-3133	197	8	chauhan	chauhan	PROPN
ijpds-3133	198	1	[	[	X
ijpds-3133	198	2	57	57	NUM
ijpds-3133	198	3	]	]	PUNCT
ijpds-3133	198	4	also	also	ADV
ijpds-3133	198	5	developed	develop	VERB
ijpds-3133	198	6	a	a	DET
ijpds-3133	198	7	lens	lens	NOUN
ijpds-3133	198	8	with	with	ADP
ijpds-3133	198	9	highly	highly	ADV
ijpds-3133	198	10	crosslinked	crosslinked	ADJ
ijpds-3133	198	11	particles	particle	NOUN
ijpds-3133	198	12	consisting	consist	VERB
ijpds-3133	198	13	of	of	ADP
ijpds-3133	198	14	monomeric	monomeric	ADJ
ijpds-3133	198	15	units	unit	NOUN
ijpds-3133	198	16	with	with	ADP
ijpds-3133	198	17	multi	multi	ADJ
ijpds-3133	198	18	vinyl	vinyl	NOUN
ijpds-3133	198	19	functionalities	functionality	NOUN
ijpds-3133	198	20	such	such	ADJ
ijpds-3133	198	21	as	as	ADP
ijpds-3133	198	22	pgt	pgt	PROPN
ijpds-3133	198	23	and	and	CCONJ
ijpds-3133	198	24	ethylene	ethylene	NOUN
ijpds-3133	198	25	glycol	glycol	NOUN
ijpds-3133	198	26	dimethacrylate	dimethacrylate	NOUN
ijpds-3133	198	27	(	(	PUNCT
ijpds-3133	198	28	egdma	egdma	NOUN
ijpds-3133	198	29	)	)	PUNCT
ijpds-3133	198	30	.	.	PUNCT
ijpds-3133	199	1	the	the	DET
ijpds-3133	199	2	3.5	3.5	NUM
ijpds-3133	199	3	-	-	PUNCT
ijpds-3133	199	4	nm	nm	NOUN
ijpds-3133	199	5	nanoparticles	nanoparticle	NOUN
ijpds-3133	199	6	encapsulated	encapsulate	VERB
ijpds-3133	199	7	48–66	48–66	NUM
ijpds-3133	199	8	%	%	NOUN
ijpds-3133	199	9	of	of	ADP
ijpds-3133	199	10	the	the	DET
ijpds-3133	199	11	drugs	drug	NOUN
ijpds-3133	199	12	.	.	PUNCT
ijpds-3133	200	1	the	the	DET
ijpds-3133	200	2	rate	rate	NOUN
ijpds-3133	200	3	constant	constant	ADJ
ijpds-3133	200	4	of	of	ADP
ijpds-3133	200	5	ester	ester	NOUN
ijpds-3133	200	6	hydrolysis	hydrolysis	NOUN
ijpds-3133	200	7	was	be	AUX
ijpds-3133	200	8	significantly	significantly	ADV
ijpds-3133	200	9	less	less	ADJ
ijpds-3133	200	10	than	than	ADP
ijpds-3133	200	11	those	those	PRON
ijpds-3133	200	12	of	of	ADP
ijpds-3133	200	13	the	the	DET
ijpds-3133	200	14	previous	previous	ADJ
ijpds-3133	200	15	models	model	NOUN
ijpds-3133	200	16	developed	develop	VERB
ijpds-3133	200	17	by	by	ADP
ijpds-3133	200	18	the	the	DET
ijpds-3133	200	19	same	same	ADJ
ijpds-3133	200	20	group	group	NOUN
ijpds-3133	200	21	,	,	PUNCT
ijpds-3133	200	22	possibly	possibly	ADV
ijpds-3133	200	23	due	due	ADP
ijpds-3133	200	24	to	to	ADP
ijpds-3133	200	25	steric	steric	ADJ
ijpds-3133	200	26	effects	effect	NOUN
ijpds-3133	200	27	and	and	CCONJ
ijpds-3133	200	28	the	the	DET
ijpds-3133	200	29	low	low	ADJ
ijpds-3133	200	30	water	water	NOUN
ijpds-3133	200	31	content	content	NOUN
ijpds-3133	200	32	of	of	ADP
ijpds-3133	200	33	the	the	DET
ijpds-3133	200	34	highly	highly	ADV
ijpds-3133	200	35	cross	cross	ADJ
ijpds-3133	200	36	-	-	ADJ
ijpds-3133	200	37	linked	link	VERB
ijpds-3133	200	38	hydrophobic	hydrophobic	NOUN
ijpds-3133	200	39	particles	particle	NOUN
ijpds-3133	200	40	.	.	PUNCT
ijpds-3133	201	1	the	the	DET
ijpds-3133	201	2	nanoparticles	nanoparticle	NOUN
ijpds-3133	201	3	dispersing	disperse	VERB
ijpds-3133	201	4	timolol	timolol	NOUN
ijpds-3133	201	5	were	be	AUX
ijpds-3133	201	6	encapsulated	encapsulate	VERB
ijpds-3133	201	7	with	with	ADP
ijpds-3133	201	8	linked	link	VERB
ijpds-3133	201	9	nanoparticles	nanoparticle	NOUN
ijpds-3133	201	10	enclosed	enclose	VERB
ijpds-3133	201	11	within	within	ADP
ijpds-3133	201	12	contact	contact	NOUN
ijpds-3133	201	13	lenses	lense	NOUN
ijpds-3133	201	14	,	,	PUNCT
ijpds-3133	201	15	which	which	PRON
ijpds-3133	201	16	increases	increase	VERB
ijpds-3133	201	17	the	the	DET
ijpds-3133	201	18	duration	duration	NOUN
ijpds-3133	201	19	of	of	ADP
ijpds-3133	201	20	drug	drug	NOUN
ijpds-3133	201	21	release	release	NOUN
ijpds-3133	201	22	from	from	ADP
ijpds-3133	201	23	1	1	NUM
ijpds-3133	201	24	to	to	PART
ijpds-3133	201	25	2	2	NUM
ijpds-3133	201	26	h	h	NOUN
ijpds-3133	201	27	to	to	ADP
ijpds-3133	201	28	about	about	ADV
ijpds-3133	201	29	four	four	NUM
ijpds-3133	201	30	weeks	week	NOUN
ijpds-3133	201	31	.	.	PUNCT
ijpds-3133	202	1	the	the	DET
ijpds-3133	202	2	drug	drug	NOUN
ijpds-3133	202	3	-	-	PUNCT
ijpds-3133	202	4	dispensing	dispense	VERB
ijpds-3133	202	5	particles	particle	NOUN
ijpds-3133	202	6	were	be	AUX
ijpds-3133	202	7	dispersed	disperse	VERB
ijpds-3133	202	8	in	in	ADP
ijpds-3133	202	9	hydroxymethyl	hydroxymethyl	NOUN
ijpds-3133	202	10	methacrylate	methacrylate	NOUN
ijpds-3133	202	11	(	(	PUNCT
ijpds-3133	202	12	hema	hema	NOUN
ijpds-3133	202	13	)	)	PUNCT
ijpds-3133	202	14	gels	gel	NOUN
ijpds-3133	202	15	that	that	PRON
ijpds-3133	202	16	were	be	AUX
ijpds-3133	202	17	commonly	commonly	ADV
ijpds-3133	202	18	used	use	VERB
ijpds-3133	202	19	for	for	ADP
ijpds-3133	202	20	manufacturing	manufacture	VERB
ijpds-3133	202	21	contact	contact	NOUN
ijpds-3133	202	22	lenses	lense	NOUN
ijpds-3133	202	23	.	.	PUNCT
ijpds-3133	203	1	xu	xu	PROPN
ijpds-3133	203	2	and	and	CCONJ
ijpds-3133	203	3	colleagues	colleague	NOUN
ijpds-3133	204	1	[	[	X
ijpds-3133	204	2	58	58	NUM
ijpds-3133	204	3	]	]	PUNCT
ijpds-3133	204	4	developed	develop	VERB
ijpds-3133	204	5	micelles	micelle	NOUN
ijpds-3133	204	6	that	that	PRON
ijpds-3133	204	7	could	could	AUX
ijpds-3133	204	8	be	be	AUX
ijpds-3133	204	9	loaded	load	VERB
ijpds-3133	204	10	on	on	ADP
ijpds-3133	204	11	the	the	DET
ijpds-3133	204	12	contact	contact	NOUN
ijpds-3133	204	13	lenses	lense	NOUN
ijpds-3133	204	14	for	for	ADP
ijpds-3133	204	15	sustained	sustained	ADJ
ijpds-3133	204	16	release	release	NOUN
ijpds-3133	204	17	of	of	ADP
ijpds-3133	204	18	timolol	timolol	NOUN
ijpds-3133	204	19	and	and	CCONJ
ijpds-3133	204	20	latanoprost	latanoprost	VERB
ijpds-3133	204	21	simultaneously	simultaneously	ADV
ijpds-3133	204	22	for	for	ADP
ijpds-3133	204	23	management	management	NOUN
ijpds-3133	204	24	of	of	ADP
ijpds-3133	204	25	glaucoma	glaucoma	NOUN
ijpds-3133	204	26	.	.	PUNCT
ijpds-3133	205	1	the	the	DET
ijpds-3133	205	2	micelles	micelle	NOUN
ijpds-3133	205	3	were	be	AUX
ijpds-3133	205	4	synthesized	synthesize	VERB
ijpds-3133	205	5	by	by	ADP
ijpds-3133	205	6	free	free	ADJ
ijpds-3133	205	7	radical	radical	ADJ
ijpds-3133	205	8	polymerization	polymerization	NOUN
ijpds-3133	205	9	of	of	ADP
ijpds-3133	205	10	the	the	DET
ijpds-3133	205	11	hema	hema	PROPN
ijpds-3133	205	12	monomer	monomer	PROPN
ijpds-3133	205	13	with	with	ADP
ijpds-3133	205	14	timolol	timolol	NOUN
ijpds-3133	205	15	and	and	CCONJ
ijpds-3133	205	16	latanoprost	latanoprost	ADJ
ijpds-3133	205	17	.	.	PUNCT
ijpds-3133	206	1	the	the	DET
ijpds-3133	206	2	lenses	lense	NOUN
ijpds-3133	206	3	released	release	VERB
ijpds-3133	206	4	timolol	timolol	NOUN
ijpds-3133	206	5	and	and	CCONJ
ijpds-3133	206	6	latanoprost	latanoprost	VERB
ijpds-3133	206	7	in	in	ADP
ijpds-3133	206	8	tear	tear	ADJ
ijpds-3133	206	9	fluid	fluid	NOUN
ijpds-3133	206	10	for	for	ADP
ijpds-3133	206	11	144	144	NUM
ijpds-3133	206	12	and	and	CCONJ
ijpds-3133	206	13	120	120	NUM
ijpds-3133	206	14	h	h	NOUN
ijpds-3133	206	15	,	,	PUNCT
ijpds-3133	206	16	respectively	respectively	ADV
ijpds-3133	206	17	.	.	PUNCT
ijpds-3133	207	1	the	the	DET
ijpds-3133	207	2	in	in	ADP
ijpds-3133	207	3	vivo	vivo	ADJ
ijpds-3133	207	4	data	datum	NOUN
ijpds-3133	207	5	showed	show	VERB
ijpds-3133	207	6	sustained	sustained	ADJ
ijpds-3133	207	7	timolol	timolol	NOUN
ijpds-3133	207	8	and	and	CCONJ
ijpds-3133	207	9	latanoprost	latanoprost	ADJ
ijpds-3133	207	10	release	release	NOUN
ijpds-3133	207	11	for	for	ADP
ijpds-3133	207	12	120	120	NUM
ijpds-3133	207	13	and	and	CCONJ
ijpds-3133	207	14	96	96	NUM
ijpds-3133	207	15	h	h	NOUN
ijpds-3133	207	16	in	in	ADP
ijpds-3133	207	17	tear	tear	ADJ
ijpds-3133	207	18	fluid	fluid	NOUN
ijpds-3133	207	19	,	,	PUNCT
ijpds-3133	207	20	respectively	respectively	ADV
ijpds-3133	207	21	.	.	PUNCT
ijpds-3133	208	1	nanospheres	nanosphere	VERB
ijpds-3133	208	2	/microspheresthe	/microspheresthe	DET
ijpds-3133	208	3	penetration	penetration	NOUN
ijpds-3133	208	4	of	of	ADP
ijpds-3133	208	5	drugs	drug	NOUN
ijpds-3133	208	6	loaded	load	VERB
ijpds-3133	208	7	on	on	ADP
ijpds-3133	208	8	the	the	DET
ijpds-3133	208	9	nanosphere	nanosphere	NOUN
ijpds-3133	208	10	depends	depend	VERB
ijpds-3133	208	11	on	on	ADP
ijpds-3133	208	12	the	the	DET
ijpds-3133	208	13	size	size	NOUN
ijpds-3133	208	14	,	,	PUNCT
ijpds-3133	208	15	charge	charge	NOUN
ijpds-3133	208	16	,	,	PUNCT
ijpds-3133	208	17	architecture	architecture	NOUN
ijpds-3133	208	18	,	,	PUNCT
ijpds-3133	208	19	and	and	CCONJ
ijpds-3133	208	20	surface	surface	NOUN
ijpds-3133	208	21	of	of	ADP
ijpds-3133	208	22	the	the	DET
ijpds-3133	208	23	carrier	carrier	NOUN
ijpds-3133	208	24	nanoparticle	nanoparticle	NOUN
ijpds-3133	208	25	systems	system	NOUN
ijpds-3133	208	26	[	[	X
ijpds-3133	208	27	59	59	NUM
ijpds-3133	208	28	,	,	PUNCT
ijpds-3133	208	29	60	60	NUM
ijpds-3133	208	30	]	]	PUNCT
ijpds-3133	208	31	.	.	PUNCT
ijpds-3133	209	1	the	the	DET
ijpds-3133	209	2	architecture	architecture	NOUN
ijpds-3133	209	3	of	of	ADP
ijpds-3133	209	4	the	the	DET
ijpds-3133	209	5	nanospheres	nanosphere	NOUN
ijpds-3133	209	6	consists	consist	VERB
ijpds-3133	209	7	of	of	ADP
ijpds-3133	209	8	a	a	DET
ijpds-3133	209	9	di	di	ADJ
ijpds-3133	209	10	-	-	PUNCT
ijpds-3133	209	11	block	block	NOUN
ijpds-3133	209	12	copolymer	copolymer	NOUN
ijpds-3133	209	13	that	that	PRON
ijpds-3133	209	14	is	be	AUX
ijpds-3133	209	15	a	a	DET
ijpds-3133	209	16	hydrophobic	hydrophobic	NOUN
ijpds-3133	209	17	block	block	NOUN
ijpds-3133	209	18	[	[	X
ijpds-3133	209	19	polycaprolactone	polycaprolactone	NOUN
ijpds-3133	209	20	(	(	PUNCT
ijpds-3133	209	21	pcl	pcl	PROPN
ijpds-3133	209	22	)	)	PUNCT
ijpds-3133	209	23	]	]	PUNCT
ijpds-3133	209	24	,	,	PUNCT
ijpds-3133	209	25	a	a	DET
ijpds-3133	209	26	hydrophilic	hydrophilic	ADJ
ijpds-3133	209	27	component	component	NOUN
ijpds-3133	209	28	[	[	X
ijpds-3133	209	29	polyethylene	polyethylene	NOUN
ijpds-3133	209	30	glycol	glycol	NOUN
ijpds-3133	209	31	(	(	PUNCT
ijpds-3133	209	32	peg	peg	NOUN
ijpds-3133	209	33	)	)	PUNCT
ijpds-3133	209	34	]	]	PUNCT
ijpds-3133	209	35	.	.	PUNCT
ijpds-3133	210	1	the	the	DET
ijpds-3133	210	2	unique	unique	ADJ
ijpds-3133	210	3	structure	structure	NOUN
ijpds-3133	210	4	of	of	ADP
ijpds-3133	210	5	nanospheres	nanosphere	NOUN
ijpds-3133	210	6	allows	allow	VERB
ijpds-3133	210	7	a	a	DET
ijpds-3133	210	8	longer	long	ADJ
ijpds-3133	210	9	residence	residence	NOUN
ijpds-3133	210	10	time	time	NOUN
ijpds-3133	210	11	on	on	ADP
ijpds-3133	210	12	the	the	DET
ijpds-3133	210	13	surface	surface	NOUN
ijpds-3133	210	14	of	of	ADP
ijpds-3133	210	15	the	the	DET
ijpds-3133	210	16	cornea	cornea	NOUN
ijpds-3133	210	17	to	to	PART
ijpds-3133	210	18	provide	provide	VERB
ijpds-3133	210	19	the	the	DET
ijpds-3133	210	20	drug	drug	NOUN
ijpds-3133	210	21	with	with	ADP
ijpds-3133	210	22	a	a	DET
ijpds-3133	210	23	carrier	carrier	NOUN
ijpds-3133	210	24	followed	follow	VERB
ijpds-3133	210	25	by	by	ADP
ijpds-3133	210	26	fusion	fusion	NOUN
ijpds-3133	210	27	with	with	ADP
ijpds-3133	210	28	the	the	DET
ijpds-3133	210	29	corneal	corneal	ADJ
ijpds-3133	210	30	epithelial	epithelial	ADJ
ijpds-3133	210	31	membrane	membrane	NOUN
ijpds-3133	210	32	,	,	PUNCT
ijpds-3133	210	33	hence	hence	ADV
ijpds-3133	210	34	reducing	reduce	VERB
ijpds-3133	210	35	the	the	DET
ijpds-3133	210	36	dosing	dose	VERB
ijpds-3133	210	37	frequency	frequency	NOUN
ijpds-3133	210	38	[	[	X
ijpds-3133	210	39	61	61	NUM
ijpds-3133	210	40	]	]	PUNCT
ijpds-3133	210	41	.	.	PUNCT
ijpds-3133	211	1	chiang	chiang	PROPN
ijpds-3133	211	2	et	et	PROPN
ijpds-3133	211	3	al	al	PROPN
ijpds-3133	211	4	.	.	PUNCT
ijpds-3133	212	1	[	[	X
ijpds-3133	212	2	62	62	NUM
ijpds-3133	212	3	]	]	PUNCT
ijpds-3133	212	4	initially	initially	ADV
ijpds-3133	212	5	reported	report	VERB
ijpds-3133	212	6	6	6	NUM
ijpds-3133	212	7	mmhg	mmhg	NOUN
ijpds-3133	212	8	with	with	ADP
ijpds-3133	212	9	brimonidine	brimonidine	NOUN
ijpds-3133	212	10	polylactic	polylactic	ADJ
ijpds-3133	212	11	acid	acid	NOUN
ijpds-3133	212	12	(	(	PUNCT
ijpds-3133	212	13	pla	pla	NOUN
ijpds-3133	212	14	)	)	PUNCT
ijpds-3133	212	15	microspheres	microsphere	NOUN
ijpds-3133	212	16	that	that	PRON
ijpds-3133	212	17	results	result	VERB
ijpds-3133	212	18	in	in	ADP
ijpds-3133	212	19	reduced	reduced	ADJ
ijpds-3133	212	20	iop	iop	NOUN
ijpds-3133	212	21	for	for	ADP
ijpds-3133	212	22	one	one	NUM
ijpds-3133	212	23	month	month	NOUN
ijpds-3133	212	24	in	in	ADP
ijpds-3133	212	25	normotensive	normotensive	ADJ
ijpds-3133	212	26	rabbit	rabbit	NOUN
ijpds-3133	212	27	eyes	eye	NOUN
ijpds-3133	212	28	.	.	PUNCT
ijpds-3133	213	1	the	the	DET
ijpds-3133	213	2	in	in	ADV
ijpds-3133	213	3	vitro	vitro	X
ijpds-3133	213	4	analysis	analysis	NOUN
ijpds-3133	213	5	of	of	ADP
ijpds-3133	213	6	the	the	DET
ijpds-3133	213	7	brimonidine	brimonidine	NOUN
ijpds-3133	213	8	microspheres	microsphere	NOUN
ijpds-3133	213	9	showed	show	VERB
ijpds-3133	213	10	a	a	DET
ijpds-3133	213	11	sustained	sustained	ADJ
ijpds-3133	213	12	release	release	NOUN
ijpds-3133	213	13	of	of	ADP
ijpds-3133	213	14	the	the	DET
ijpds-3133	213	15	drug	drug	NOUN
ijpds-3133	213	16	for	for	ADP
ijpds-3133	213	17	35	35	NUM
ijpds-3133	213	18	days	day	NOUN
ijpds-3133	213	19	.	.	PUNCT
ijpds-3133	214	1	ohr1031it	ohr1031it	NOUN
ijpds-3133	214	2	is	be	AUX
ijpds-3133	214	3	a	a	DET
ijpds-3133	214	4	macromolecular	macromolecular	ADJ
ijpds-3133	214	5	drug	drug	NOUN
ijpds-3133	214	6	for	for	ADP
ijpds-3133	214	7	glaucoma	glaucoma	NOUN
ijpds-3133	214	8	management	management	NOUN
ijpds-3133	214	9	that	that	PRON
ijpds-3133	214	10	incorporates	incorporate	VERB
ijpds-3133	214	11	into	into	ADP
ijpds-3133	214	12	microparticles	microparticle	NOUN
ijpds-3133	214	13	using	use	VERB
ijpds-3133	214	14	a	a	DET
ijpds-3133	214	15	dissolvable	dissolvable	ADJ
ijpds-3133	214	16	hydrogel	hydrogel	NOUN
ijpds-3133	214	17	template	template	NOUN
ijpds-3133	214	18	technology	technology	NOUN
ijpds-3133	214	19	[	[	X
ijpds-3133	214	20	63	63	NUM
ijpds-3133	214	21	]	]	PUNCT
ijpds-3133	214	22	.	.	PUNCT
ijpds-3133	215	1	the	the	DET
ijpds-3133	215	2	drug	drug	NOUN
ijpds-3133	215	3	is	be	AUX
ijpds-3133	215	4	dissolved	dissolve	VERB
ijpds-3133	215	5	into	into	ADP
ijpds-3133	215	6	a	a	DET
ijpds-3133	215	7	plga	plga	NOUN
ijpds-3133	215	8	polymer	polymer	NOUN
ijpds-3133	215	9	-	-	PUNCT
ijpds-3133	215	10	solvent	solvent	NOUN
ijpds-3133	215	11	mixture	mixture	NOUN
ijpds-3133	215	12	,	,	PUNCT
ijpds-3133	215	13	and	and	CCONJ
ijpds-3133	215	14	the	the	DET
ijpds-3133	215	15	microparticles	microparticle	NOUN
ijpds-3133	215	16	are	be	AUX
ijpds-3133	215	17	formed	form	VERB
ijpds-3133	215	18	using	use	VERB
ijpds-3133	215	19	the	the	DET
ijpds-3133	215	20	dissolvable	dissolvable	ADJ
ijpds-3133	215	21	template	template	NOUN
ijpds-3133	215	22	technology	technology	NOUN
ijpds-3133	215	23	.	.	PUNCT
ijpds-3133	216	1	the	the	DET
ijpds-3133	216	2	median	median	ADJ
ijpds-3133	216	3	size	size	NOUN
ijpds-3133	216	4	of	of	ADP
ijpds-3133	216	5	drug	drug	NOUN
ijpds-3133	216	6	-	-	PUNCT
ijpds-3133	216	7	loaded	load	VERB
ijpds-3133	216	8	particles	particle	NOUN
ijpds-3133	216	9	is	be	AUX
ijpds-3133	216	10	60	60	NUM
ijpds-3133	216	11	μm	μm	NOUN
ijpds-3133	216	12	.	.	PUNCT
ijpds-3133	217	1	the	the	DET
ijpds-3133	217	2	authors	author	NOUN
ijpds-3133	217	3	reported	report	VERB
ijpds-3133	217	4	that	that	SCONJ
ijpds-3133	217	5	the	the	DET
ijpds-3133	217	6	ohr1031	ohr1031	NOUN
ijpds-3133	217	7	content	content	NOUN
ijpds-3133	217	8	in	in	ADP
ijpds-3133	217	9	the	the	DET
ijpds-3133	217	10	microparticles	microparticle	NOUN
ijpds-3133	217	11	was	be	AUX
ijpds-3133	217	12	57%-100	57%-100	NUM
ijpds-3133	217	13	%	%	NOUN
ijpds-3133	217	14	incorporation	incorporation	NOUN
ijpds-3133	217	15	efficiency	efficiency	NOUN
ijpds-3133	217	16	.	.	PUNCT
ijpds-3133	218	1	the	the	DET
ijpds-3133	218	2	rai	rai	PROPN
ijpds-3133	218	3	et	et	PROPN
ijpds-3133	218	4	al	al	PROPN
ijpds-3133	218	5	mindful	mindful	ADJ
ijpds-3133	218	6	-	-	PUNCT
ijpds-3133	218	7	based	base	VERB
ijpds-3133	218	8	stress	stress	NOUN
ijpds-3133	218	9	reduction	reduction	NOUN
ijpds-3133	218	10	impact	impact	NOUN
ijpds-3133	218	11	vol	vol	NOUN
ijpds-3133	218	12	1	1	NUM
ijpds-3133	218	13	|	|	NOUN
ijpds-3133	218	14	issue	issue	NOUN
ijpds-3133	218	15	2	2	NUM
ijpds-3133	218	16	|	|	ADV
ijpds-3133	218	17	jul	jul	PROPN
ijpds-3133	218	18	–	–	PUNCT
ijpds-3133	218	19	sep	sep	PROPN
ijpds-3133	218	20	2022	2022	NUM
ijpds-3133	218	21	indian	indian	PROPN
ijpds-3133	218	22	j	j	PROPN
ijpds-3133	218	23	pharm	pharm	PROPN
ijpds-3133	218	24	drug	drug	PROPN
ijpds-3133	218	25	studies	study	NOUN
ijpds-3133	218	26	|	|	ADV
ijpds-3133	218	27	43	43	NUM
ijpds-3133	218	28	drug	drug	NOUN
ijpds-3133	218	29	release	release	NOUN
ijpds-3133	218	30	rate	rate	NOUN
ijpds-3133	218	31	was	be	AUX
ijpds-3133	218	32	nearly	nearly	ADV
ijpds-3133	218	33	zero	zero	NUM
ijpds-3133	218	34	-	-	PUNCT
ijpds-3133	218	35	order	order	NOUN
ijpds-3133	218	36	for	for	ADP
ijpds-3133	218	37	over	over	ADP
ijpds-3133	218	38	three	three	NUM
ijpds-3133	218	39	months	month	NOUN
ijpds-3133	218	40	with	with	ADP
ijpds-3133	218	41	virtually	virtually	ADV
ijpds-3133	218	42	no	no	PRON
ijpds-3133	218	43	initial	initial	ADJ
ijpds-3133	218	44	burst	burst	NOUN
ijpds-3133	218	45	.	.	PUNCT
ijpds-3133	219	1	solidropsolidrop	solidropsolidrop	NOUN
ijpds-3133	219	2	by	by	ADP
ijpds-3133	219	3	otero	otero	NOUN
ijpds-3133	219	4	therapeutics	therapeutic	NOUN
ijpds-3133	219	5	consists	consist	VERB
ijpds-3133	219	6	of	of	ADP
ijpds-3133	219	7	a	a	DET
ijpds-3133	219	8	thermoresponsive	thermoresponsive	ADJ
ijpds-3133	219	9	hydrogel	hydrogel	NOUN
ijpds-3133	219	10	carrier	carrier	NOUN
ijpds-3133	219	11	and	and	CCONJ
ijpds-3133	219	12	drug	drug	NOUN
ijpds-3133	219	13	-	-	PUNCT
ijpds-3133	219	14	loaded	load	VERB
ijpds-3133	219	15	polymer	polymer	NOUN
ijpds-3133	219	16	microspheres	microsphere	NOUN
ijpds-3133	219	17	.	.	PUNCT
ijpds-3133	220	1	on	on	ADP
ijpds-3133	220	2	administering	administer	VERB
ijpds-3133	220	3	a	a	DET
ijpds-3133	220	4	single	single	ADJ
ijpds-3133	220	5	brimonidine	brimonidine	NOUN
ijpds-3133	220	6	-	-	PUNCT
ijpds-3133	220	7	loaded	load	VERB
ijpds-3133	220	8	gel	gel	NOUN
ijpds-3133	220	9	/	/	SYM
ijpds-3133	220	10	microsphere	microsphere	NOUN
ijpds-3133	220	11	drop	drop	VERB
ijpds-3133	220	12	,	,	PUNCT
ijpds-3133	220	13	the	the	DET
ijpds-3133	220	14	ioplowering	ioplowere	VERB
ijpds-3133	220	15	efficacy	efficacy	NOUN
ijpds-3133	220	16	(	(	PUNCT
ijpds-3133	220	17	reduced	reduce	VERB
ijpds-3133	220	18	by	by	ADP
ijpds-3133	220	19	30	30	NUM
ijpds-3133	220	20	%	%	NOUN
ijpds-3133	220	21	of	of	ADP
ijpds-3133	220	22	baseline	baseline	PROPN
ijpds-3133	220	23	iop	iop	PROPN
ijpds-3133	220	24	)	)	PUNCT
ijpds-3133	220	25	was	be	AUX
ijpds-3133	220	26	comparable	comparable	ADJ
ijpds-3133	220	27	to	to	ADP
ijpds-3133	220	28	that	that	PRON
ijpds-3133	220	29	of	of	ADP
ijpds-3133	220	30	rabbits	rabbit	NOUN
ijpds-3133	220	31	receiving	receive	VERB
ijpds-3133	220	32	twice	twice	ADV
ijpds-3133	220	33	-	-	PUNCT
ijpds-3133	220	34	daily	daily	ADJ
ijpds-3133	220	35	,	,	PUNCT
ijpds-3133	220	36	standard	standard	ADJ
ijpds-3133	220	37	brimonidine	brimonidine	NOUN
ijpds-3133	220	38	drops	drop	VERB
ijpds-3133	220	39	for	for	ADP
ijpds-3133	220	40	28	28	NUM
ijpds-3133	220	41	days	day	NOUN
ijpds-3133	220	42	.	.	PUNCT
ijpds-3133	221	1	the	the	DET
ijpds-3133	221	2	gel	gel	NOUN
ijpds-3133	221	3	drops	drop	NOUN
ijpds-3133	221	4	were	be	AUX
ijpds-3133	221	5	retained	retain	VERB
ijpds-3133	221	6	in	in	ADP
ijpds-3133	221	7	the	the	DET
ijpds-3133	221	8	fornix	fornix	NOUN
ijpds-3133	221	9	during	during	ADP
ijpds-3133	221	10	the	the	DET
ijpds-3133	221	11	entire	entire	ADJ
ijpds-3133	221	12	period	period	NOUN
ijpds-3133	221	13	of	of	ADP
ijpds-3133	221	14	the	the	DET
ijpds-3133	221	15	study	study	NOUN
ijpds-3133	221	16	[	[	X
ijpds-3133	221	17	64	64	NUM
ijpds-3133	221	18	]	]	PUNCT
ijpds-3133	221	19	.	.	PUNCT
ijpds-3133	222	1	env	env	NOUN
ijpds-3133	222	2	515	515	NUM
ijpds-3133	222	3	/	/	SYM
ijpds-3133	222	4	travoprost	travoprost	ADJ
ijpds-3133	222	5	xrenv515	xrenv515	PROPN
ijpds-3133	222	6	pga	pga	PROPN
ijpds-3133	222	7	/	/	SYM
ijpds-3133	222	8	travoprost	travoprost	ADJ
ijpds-3133	222	9	xr	xr	PROPN
ijpds-3133	222	10	therapy	therapy	NOUN
ijpds-3133	222	11	is	be	AUX
ijpds-3133	222	12	a	a	DET
ijpds-3133	222	13	particle	particle	NOUN
ijpds-3133	222	14	replication	replication	NOUN
ijpds-3133	222	15	in	in	ADP
ijpds-3133	222	16	a	a	DET
ijpds-3133	222	17	nonwetting	nonwetting	NOUN
ijpds-3133	222	18	templatebased	templatebase	VERB
ijpds-3133	222	19	biodegradable	biodegradable	ADJ
ijpds-3133	222	20	polymer	polymer	NOUN
ijpds-3133	222	21	drug	drug	NOUN
ijpds-3133	222	22	delivery	delivery	NOUN
ijpds-3133	222	23	system	system	NOUN
ijpds-3133	222	24	.	.	PUNCT
ijpds-3133	223	1	the	the	DET
ijpds-3133	223	2	implant	implant	NOUN
ijpds-3133	223	3	is	be	AUX
ijpds-3133	223	4	rod	rod	NOUN
ijpds-3133	223	5	-	-	PUNCT
ijpds-3133	223	6	shaped	shape	VERB
ijpds-3133	223	7	and	and	CCONJ
ijpds-3133	223	8	fits	fit	VERB
ijpds-3133	223	9	the	the	DET
ijpds-3133	223	10	anatomy	anatomy	NOUN
ijpds-3133	223	11	of	of	ADP
ijpds-3133	223	12	the	the	DET
ijpds-3133	223	13	iridocorneal	iridocorneal	ADJ
ijpds-3133	223	14	angle	angle	NOUN
ijpds-3133	223	15	in	in	ADP
ijpds-3133	223	16	the	the	DET
ijpds-3133	223	17	anterior	anterior	ADJ
ijpds-3133	223	18	chamber	chamber	NOUN
ijpds-3133	223	19	,	,	PUNCT
ijpds-3133	223	20	allowing	allow	VERB
ijpds-3133	223	21	its	its	PRON
ijpds-3133	223	22	administration	administration	NOUN
ijpds-3133	223	23	via	via	ADP
ijpds-3133	223	24	an	an	DET
ijpds-3133	223	25	acceptably	acceptably	ADV
ijpds-3133	223	26	sized	sized	ADJ
ijpds-3133	223	27	needle	needle	NOUN
ijpds-3133	223	28	.	.	PUNCT
ijpds-3133	224	1	the	the	DET
ijpds-3133	224	2	result	result	NOUN
ijpds-3133	224	3	from	from	ADP
ijpds-3133	224	4	the	the	DET
ijpds-3133	224	5	phase	phase	NOUN
ijpds-3133	224	6	ii	ii	NOUN
ijpds-3133	224	7	clinical	clinical	ADJ
ijpds-3133	224	8	trial	trial	NOUN
ijpds-3133	224	9	reported	report	VERB
ijpds-3133	224	10	that	that	SCONJ
ijpds-3133	224	11	a	a	DET
ijpds-3133	224	12	single	single	ADJ
ijpds-3133	224	13	low	low	ADJ
ijpds-3133	224	14	dose	dose	NOUN
ijpds-3133	224	15	of	of	ADP
ijpds-3133	224	16	env515	env515	PROPN
ijpds-3133	224	17	decreases	decrease	VERB
ijpds-3133	224	18	the	the	DET
ijpds-3133	224	19	mean	mean	ADJ
ijpds-3133	224	20	iop	iop	NOUN
ijpds-3133	224	21	by	by	ADP
ijpds-3133	224	22	6.7	6.7	NUM
ijpds-3133	224	23	±	±	NUM
ijpds-3133	224	24	3.7	3.7	NUM
ijpds-3133	224	25	mmhg	mmhg	NOUN
ijpds-3133	224	26	over	over	ADP
ijpds-3133	224	27	eleven	eleven	NUM
ijpds-3133	224	28	months	month	NOUN
ijpds-3133	224	29	.	.	PUNCT
ijpds-3133	225	1	the	the	DET
ijpds-3133	225	2	mean	mean	ADJ
ijpds-3133	225	3	iop	iop	NOUN
ijpds-3133	225	4	after	after	ADP
ijpds-3133	225	5	a	a	DET
ijpds-3133	225	6	single	single	ADJ
ijpds-3133	225	7	low	low	ADJ
ijpds-3133	225	8	dose	dose	NOUN
ijpds-3133	225	9	of	of	ADP
ijpds-3133	225	10	env515	env515	PROPN
ijpds-3133	225	11	was	be	AUX
ijpds-3133	225	12	19.5	19.5	NUM
ijpds-3133	225	13	mmhg	mmhg	NOUN
ijpds-3133	225	14	over	over	ADP
ijpds-3133	225	15	the	the	DET
ijpds-3133	225	16	11	11	NUM
ijpds-3133	225	17	months	month	NOUN
ijpds-3133	225	18	[	[	X
ijpds-3133	225	19	68	68	NUM
ijpds-3133	225	20	]	]	PUNCT
ijpds-3133	225	21	.	.	PUNCT
ijpds-3133	226	1	bimatoprost	bimatoprost	PROPN
ijpds-3133	226	2	srbimatoprost	srbimatoprost	PROPN
ijpds-3133	226	3	sr	sr	PROPN
ijpds-3133	226	4	is	be	AUX
ijpds-3133	226	5	a	a	DET
ijpds-3133	226	6	biodegradable	biodegradable	ADJ
ijpds-3133	226	7	implant	implant	NOUN
ijpds-3133	226	8	for	for	ADP
ijpds-3133	226	9	the	the	DET
ijpds-3133	226	10	decrement	decrement	NOUN
ijpds-3133	226	11	of	of	ADP
ijpds-3133	226	12	iop	iop	PROPN
ijpds-3133	226	13	with	with	ADP
ijpds-3133	226	14	a	a	DET
ijpds-3133	226	15	4	4	NUM
ijpds-3133	226	16	-	-	PUNCT
ijpds-3133	226	17	month	month	NOUN
ijpds-3133	226	18	sustained	sustained	ADJ
ijpds-3133	226	19	release	release	NOUN
ijpds-3133	226	20	period	period	NOUN
ijpds-3133	226	21	[	[	X
ijpds-3133	226	22	69	69	NUM
ijpds-3133	226	23	]	]	PUNCT
ijpds-3133	226	24	.	.	PUNCT
ijpds-3133	227	1	in	in	ADP
ijpds-3133	227	2	the	the	DET
ijpds-3133	227	3	first	first	ADJ
ijpds-3133	227	4	phase	phase	NOUN
ijpds-3133	227	5	iii	iii	NUM
ijpds-3133	227	6	clinical	clinical	ADJ
ijpds-3133	227	7	study	study	NOUN
ijpds-3133	227	8	,	,	PUNCT
ijpds-3133	227	9	bimatoprost	bimatoprost	ADJ
ijpds-3133	227	10	sr	sr	PROPN
ijpds-3133	227	11	reduced	reduce	VERB
ijpds-3133	227	12	iop	iop	NOUN
ijpds-3133	227	13	by	by	ADP
ijpds-3133	227	14	30	30	NUM
ijpds-3133	227	15	%	%	NOUN
ijpds-3133	227	16	over	over	ADP
ijpds-3133	227	17	the	the	DET
ijpds-3133	227	18	12	12	NUM
ijpds-3133	227	19	-	-	PUNCT
ijpds-3133	227	20	week	week	NOUN
ijpds-3133	227	21	primary	primary	ADJ
ijpds-3133	227	22	efficacy	efficacy	NOUN
ijpds-3133	227	23	period	period	NOUN
ijpds-3133	227	24	.	.	PUNCT
ijpds-3133	228	1	the	the	DET
ijpds-3133	228	2	results	result	NOUN
ijpds-3133	228	3	showed	show	VERB
ijpds-3133	228	4	no	no	DET
ijpds-3133	228	5	requirement	requirement	NOUN
ijpds-3133	228	6	of	of	ADP
ijpds-3133	228	7	supplementary	supplementary	ADJ
ijpds-3133	228	8	treatment	treatment	NOUN
ijpds-3133	228	9	for	for	ADP
ijpds-3133	228	10	iop	iop	NOUN
ijpds-3133	228	11	lowering	lower	VERB
ijpds-3133	228	12	for	for	ADP
ijpds-3133	228	13	one	one	NUM
ijpds-3133	228	14	year	year	NOUN
ijpds-3133	228	15	after	after	ADP
ijpds-3133	228	16	the	the	DET
ijpds-3133	228	17	last	last	ADJ
ijpds-3133	228	18	implant	implant	ADJ
ijpds-3133	228	19	insertion	insertion	NOUN
ijpds-3133	228	20	.	.	PUNCT
ijpds-3133	229	1	the	the	DET
ijpds-3133	229	2	magnitude	magnitude	NOUN
ijpds-3133	229	3	of	of	ADP
ijpds-3133	229	4	ioplowering	ioplowere	VERB
ijpds-3133	229	5	efficacy	efficacy	NOUN
ijpds-3133	229	6	with	with	ADP
ijpds-3133	229	7	bimatoprost	bimatoprost	NOUN
ijpds-3133	229	8	sr	sr	PROPN
ijpds-3133	229	9	observed	observe	VERB
ijpds-3133	229	10	in	in	ADP
ijpds-3133	229	11	this	this	DET
ijpds-3133	229	12	study	study	NOUN
ijpds-3133	229	13	is	be	AUX
ijpds-3133	229	14	similar	similar	ADJ
ijpds-3133	229	15	to	to	ADP
ijpds-3133	229	16	that	that	PRON
ijpds-3133	229	17	observed	observe	VERB
ijpds-3133	229	18	with	with	ADP
ijpds-3133	229	19	daily	daily	ADJ
ijpds-3133	229	20	topical	topical	ADJ
ijpds-3133	229	21	prostaglandin	prostaglandin	NOUN
ijpds-3133	229	22	analogs	analog	NOUN
ijpds-3133	229	23	.	.	PUNCT
ijpds-3133	230	1	bimatoprost	bimatoprost	PROPN
ijpds-3133	230	2	sr	sr	PROPN
ijpds-3133	230	3	was	be	AUX
ijpds-3133	230	4	well	well	ADV
ijpds-3133	230	5	tolerated	tolerate	VERB
ijpds-3133	230	6	in	in	ADP
ijpds-3133	230	7	the	the	DET
ijpds-3133	230	8	majority	majority	NOUN
ijpds-3133	230	9	of	of	ADP
ijpds-3133	230	10	patients	patient	NOUN
ijpds-3133	230	11	.	.	PUNCT
ijpds-3133	231	1	graybuggraybug	graybuggraybug	PROPN
ijpds-3133	231	2	is	be	AUX
ijpds-3133	231	3	a	a	DET
ijpds-3133	231	4	drug	drug	NOUN
ijpds-3133	231	5	-	-	PUNCT
ijpds-3133	231	6	encapsulated	encapsulate	VERB
ijpds-3133	231	7	microparticle	microparticle	NOUN
ijpds-3133	231	8	formulation	formulation	NOUN
ijpds-3133	231	9	to	to	PART
ijpds-3133	231	10	provide	provide	VERB
ijpds-3133	231	11	continuous	continuous	ADJ
ijpds-3133	231	12	iop	iop	NOUN
ijpds-3133	231	13	lowering	lower	VERB
ijpds-3133	231	14	that	that	PRON
ijpds-3133	231	15	is	be	AUX
ijpds-3133	231	16	administrated	administrate	VERB
ijpds-3133	231	17	by	by	ADP
ijpds-3133	231	18	the	the	DET
ijpds-3133	231	19	treating	treat	VERB
ijpds-3133	231	20	physician	physician	NOUN
ijpds-3133	231	21	every	every	DET
ijpds-3133	231	22	3	3	NUM
ijpds-3133	231	23	–	–	SYM
ijpds-3133	231	24	6	6	NUM
ijpds-3133	231	25	months	month	NOUN
ijpds-3133	231	26	using	use	VERB
ijpds-3133	231	27	a	a	DET
ijpds-3133	231	28	subconjunctival	subconjunctival	ADJ
ijpds-3133	231	29	injection	injection	NOUN
ijpds-3133	231	30	.	.	PUNCT
ijpds-3133	232	1	gb-203	gb-203	PROPN
ijpds-3133	232	2	is	be	AUX
ijpds-3133	232	3	a	a	DET
ijpds-3133	232	4	preclinical	preclinical	ADJ
ijpds-3133	232	5	stage	stage	NOUN
ijpds-3133	232	6	dual	dual	ADJ
ijpds-3133	232	7	mode	mode	NOUN
ijpds-3133	232	8	of	of	ADP
ijpds-3133	232	9	action	action	NOUN
ijpds-3133	232	10	,	,	PUNCT
ijpds-3133	232	11	single	single	ADJ
ijpds-3133	232	12	molecular	molecular	ADJ
ijpds-3133	232	13	entity	entity	NOUN
ijpds-3133	232	14	agent	agent	NOUN
ijpds-3133	232	15	that	that	PRON
ijpds-3133	232	16	can	can	AUX
ijpds-3133	232	17	hydrolyze	hydrolyze	VERB
ijpds-3133	232	18	into	into	ADP
ijpds-3133	232	19	an	an	DET
ijpds-3133	232	20	active	active	ADJ
ijpds-3133	232	21	agent	agent	NOUN
ijpds-3133	232	22	that	that	PRON
ijpds-3133	232	23	has	have	VERB
ijpds-3133	232	24	the	the	DET
ijpds-3133	232	25	potential	potential	NOUN
ijpds-3133	232	26	to	to	PART
ijpds-3133	232	27	lower	lower	VERB
ijpds-3133	232	28	iop	iop	NOUN
ijpds-3133	232	29	and	and	CCONJ
ijpds-3133	232	30	a	a	DET
ijpds-3133	232	31	second	second	ADJ
ijpds-3133	232	32	active	active	ADJ
ijpds-3133	232	33	agent	agent	NOUN
ijpds-3133	232	34	that	that	PRON
ijpds-3133	232	35	can	can	AUX
ijpds-3133	232	36	provide	provide	VERB
ijpds-3133	232	37	longterm	longterm	NOUN
ijpds-3133	232	38	neuroprotection	neuroprotection	NOUN
ijpds-3133	232	39	[	[	X
ijpds-3133	232	40	70	70	NUM
ijpds-3133	232	41	]	]	PUNCT
ijpds-3133	232	42	.	.	PUNCT
ijpds-3133	233	1	another	another	DET
ijpds-3133	233	2	pilot	pilot	NOUN
ijpds-3133	233	3	polymer	polymer	NOUN
ijpds-3133	233	4	depot	depot	NOUN
ijpds-3133	233	5	formulation	formulation	NOUN
ijpds-3133	233	6	of	of	ADP
ijpds-3133	233	7	gb-6249	gb-6249	PROPN
ijpds-3133	233	8	-	-	PUNCT
ijpds-3133	233	9	103	103	NUM
ijpds-3133	233	10	developed	develop	VERB
ijpds-3133	233	11	on	on	ADP
ijpds-3133	233	12	the	the	DET
ijpds-3133	233	13	graybug	graybug	ADJ
ijpds-3133	233	14	platform	platform	NOUN
ijpds-3133	233	15	safely	safely	ADV
ijpds-3133	233	16	has	have	AUX
ijpds-3133	233	17	been	be	AUX
ijpds-3133	233	18	shown	show	VERB
ijpds-3133	233	19	to	to	PART
ijpds-3133	233	20	deliver	deliver	VERB
ijpds-3133	233	21	its	its	PRON
ijpds-3133	233	22	payload	payload	NOUN
ijpds-3133	233	23	in	in	ADP
ijpds-3133	233	24	a	a	DET
ijpds-3133	233	25	sustained	sustained	ADJ
ijpds-3133	233	26	manner	manner	NOUN
ijpds-3133	233	27	both	both	CCONJ
ijpds-3133	233	28	in	in	ADP
ijpds-3133	233	29	vitro	vitro	X
ijpds-3133	233	30	and	and	CCONJ
ijpds-3133	233	31	in	in	ADP
ijpds-3133	233	32	vivo	vivo	NOUN
ijpds-3133	234	1	[	[	X
ijpds-3133	234	2	71	71	NUM
ijpds-3133	234	3	]	]	PUNCT
ijpds-3133	234	4	.	.	PUNCT
ijpds-3133	235	1	a	a	DET
ijpds-3133	235	2	significant	significant	ADJ
ijpds-3133	235	3	reduction	reduction	NOUN
ijpds-3133	235	4	in	in	ADP
ijpds-3133	235	5	iop	iop	PROPN
ijpds-3133	235	6	was	be	AUX
ijpds-3133	235	7	observed	observe	VERB
ijpds-3133	235	8	within	within	ADP
ijpds-3133	235	9	the	the	DET
ijpds-3133	235	10	first	first	ADJ
ijpds-3133	235	11	week	week	NOUN
ijpds-3133	235	12	following	follow	VERB
ijpds-3133	235	13	injection	injection	NOUN
ijpds-3133	235	14	of	of	ADP
ijpds-3133	235	15	the	the	DET
ijpds-3133	235	16	formulation	formulation	NOUN
ijpds-3133	235	17	in	in	ADP
ijpds-3133	235	18	rabbits	rabbit	NOUN
ijpds-3133	235	19	.	.	PUNCT
ijpds-3133	236	1	the	the	DET
ijpds-3133	236	2	results	result	NOUN
ijpds-3133	236	3	recorded	record	VERB
ijpds-3133	236	4	a	a	DET
ijpds-3133	236	5	sustained	sustained	ADJ
ijpds-3133	236	6	maximum	maximum	ADJ
ijpds-3133	236	7	iop	iop	NOUN
ijpds-3133	236	8	lowering	lowering	NOUN
ijpds-3133	236	9	of	of	ADP
ijpds-3133	236	10	~20	~20	NOUN
ijpds-3133	236	11	%	%	NOUN
ijpds-3133	236	12	over	over	ADP
ijpds-3133	236	13	two	two	NUM
ijpds-3133	236	14	months	month	NOUN
ijpds-3133	236	15	.	.	PUNCT
ijpds-3133	237	1	otx	otx	ADJ
ijpds-3133	237	2	-	-	PUNCT
ijpds-3133	237	3	tpthe	tpthe	NOUN
ijpds-3133	237	4	otx	otx	NOUN
ijpds-3133	237	5	-	-	PUNCT
ijpds-3133	237	6	tp	tp	NOUN
ijpds-3133	237	7	(	(	PUNCT
ijpds-3133	237	8	ocular	ocular	ADJ
ijpds-3133	237	9	therapeutix	therapeutix	NOUN
ijpds-3133	237	10	)	)	PUNCT
ijpds-3133	237	11	delivered	deliver	VERB
ijpds-3133	237	12	travoprost	travoprost	NOUN
ijpds-3133	237	13	to	to	ADP
ijpds-3133	237	14	the	the	DET
ijpds-3133	237	15	ocular	ocular	ADJ
ijpds-3133	237	16	surface	surface	NOUN
ijpds-3133	237	17	via	via	ADP
ijpds-3133	237	18	an	an	DET
ijpds-3133	237	19	intracanalicular	intracanalicular	ADJ
ijpds-3133	237	20	punctal	punctal	NOUN
ijpds-3133	237	21	plug	plug	NOUN
ijpds-3133	237	22	for	for	ADP
ijpds-3133	237	23	up	up	ADP
ijpds-3133	237	24	to	to	PART
ijpds-3133	237	25	three	three	NUM
ijpds-3133	237	26	months	month	NOUN
ijpds-3133	237	27	,	,	PUNCT
ijpds-3133	237	28	resorbs	resorb	NOUN
ijpds-3133	237	29	,	,	PUNCT
ijpds-3133	237	30	and	and	CCONJ
ijpds-3133	237	31	drains	drain	VERB
ijpds-3133	237	32	through	through	ADP
ijpds-3133	237	33	the	the	DET
ijpds-3133	237	34	nasolacrimal	nasolacrimal	ADJ
ijpds-3133	237	35	system	system	NOUN
ijpds-3133	237	36	[	[	X
ijpds-3133	237	37	72	72	NUM
ijpds-3133	237	38	]	]	PUNCT
ijpds-3133	237	39	.	.	PUNCT
ijpds-3133	238	1	it	it	PRON
ijpds-3133	238	2	consists	consist	VERB
ijpds-3133	238	3	of	of	ADP
ijpds-3133	238	4	pegbased	pegbase	VERB
ijpds-3133	238	5	hydrogel	hydrogel	NOUN
ijpds-3133	238	6	with	with	ADP
ijpds-3133	238	7	embedded	embed	VERB
ijpds-3133	238	8	travoprost	travoprost	VERB
ijpds-3133	238	9	–	–	PUNCT
ijpds-3133	238	10	loaded	load	VERB
ijpds-3133	238	11	pla	pla	NOUN
ijpds-3133	238	12	microspheres	microsphere	NOUN
ijpds-3133	238	13	.	.	PUNCT
ijpds-3133	239	1	these	these	DET
ijpds-3133	239	2	microspheres	microsphere	NOUN
ijpds-3133	239	3	slowly	slowly	ADV
ijpds-3133	239	4	degrade	degrade	VERB
ijpds-3133	239	5	and	and	CCONJ
ijpds-3133	239	6	show	show	VERB
ijpds-3133	239	7	a	a	DET
ijpds-3133	239	8	sustained	sustained	ADJ
ijpds-3133	239	9	drug	drug	NOUN
ijpds-3133	239	10	release	release	NOUN
ijpds-3133	239	11	over	over	ADP
ijpds-3133	239	12	30	30	NUM
ijpds-3133	239	13	days	day	NOUN
ijpds-3133	239	14	.	.	PUNCT
ijpds-3133	240	1	perera	perera	PROPN
ijpds-3133	240	2	et	et	PROPN
ijpds-3133	240	3	al	al	PROPN
ijpds-3133	240	4	.	.	PUNCT
ijpds-3133	241	1	[	[	X
ijpds-3133	241	2	73	73	NUM
ijpds-3133	241	3	]	]	PUNCT
ijpds-3133	241	4	in	in	ADP
ijpds-3133	241	5	a	a	DET
ijpds-3133	241	6	study	study	NOUN
ijpds-3133	241	7	reported	report	VERB
ijpds-3133	241	8	a	a	DET
ijpds-3133	241	9	100	100	NUM
ijpds-3133	241	10	%	%	NOUN
ijpds-3133	241	11	retention	retention	NOUN
ijpds-3133	241	12	rate	rate	NOUN
ijpds-3133	241	13	of	of	ADP
ijpds-3133	241	14	the	the	DET
ijpds-3133	241	15	plugs	plug	NOUN
ijpds-3133	241	16	,	,	PUNCT
ijpds-3133	241	17	ten	ten	NUM
ijpds-3133	241	18	days	day	NOUN
ijpds-3133	241	19	post	post	ADJ
ijpds-3133	241	20	-	-	NOUN
ijpds-3133	241	21	implantation	implantation	NOUN
ijpds-3133	241	22	,	,	PUNCT
ijpds-3133	241	23	and	and	CCONJ
ijpds-3133	241	24	a	a	DET
ijpds-3133	241	25	reduction	reduction	NOUN
ijpds-3133	241	26	in	in	ADP
ijpds-3133	241	27	iop	iop	NOUN
ijpds-3133	241	28	by	by	ADP
ijpds-3133	241	29	5.4–7.5	5.4–7.5	NUM
ijpds-3133	241	30	mmhg	mmhg	NOUN
ijpds-3133	241	31	.	.	PUNCT
ijpds-3133	242	1	it	it	PRON
ijpds-3133	242	2	is	be	AUX
ijpds-3133	242	3	minimally	minimally	ADV
ijpds-3133	242	4	invasive	invasive	ADJ
ijpds-3133	242	5	,	,	PUNCT
ijpds-3133	242	6	contains	contain	VERB
ijpds-3133	242	7	fluorescein	fluorescein	NOUN
ijpds-3133	242	8	to	to	PART
ijpds-3133	242	9	monitor	monitor	VERB
ijpds-3133	242	10	any	any	DET
ijpds-3133	242	11	retention	retention	NOUN
ijpds-3133	242	12	,	,	PUNCT
ijpds-3133	242	13	and	and	CCONJ
ijpds-3133	242	14	clears	clear	VERB
ijpds-3133	242	15	from	from	ADP
ijpds-3133	242	16	the	the	DET
ijpds-3133	242	17	body	body	NOUN
ijpds-3133	242	18	through	through	ADP
ijpds-3133	242	19	absorption	absorption	NOUN
ijpds-3133	242	20	.	.	PUNCT
ijpds-3133	243	1	the	the	DET
ijpds-3133	243	2	studies	study	NOUN
ijpds-3133	243	3	have	have	AUX
ijpds-3133	243	4	shown	show	VERB
ijpds-3133	243	5	an	an	DET
ijpds-3133	243	6	enhanced	enhanced	ADJ
ijpds-3133	243	7	therapeutic	therapeutic	ADJ
ijpds-3133	243	8	benefit	benefit	NOUN
ijpds-3133	243	9	for	for	ADP
ijpds-3133	243	10	90	90	NUM
ijpds-3133	243	11	days	day	NOUN
ijpds-3133	243	12	with	with	ADP
ijpds-3133	243	13	a	a	DET
ijpds-3133	243	14	consistent	consistent	ADJ
ijpds-3133	243	15	90	90	NUM
ijpds-3133	243	16	%	%	NOUN
ijpds-3133	243	17	retention	retention	NOUN
ijpds-3133	243	18	rate	rate	NOUN
ijpds-3133	243	19	.	.	PUNCT
ijpds-3133	244	1	the	the	DET
ijpds-3133	244	2	phase	phase	NOUN
ijpds-3133	244	3	ii	ii	NOUN
ijpds-3133	244	4	trial	trial	NOUN
ijpds-3133	244	5	did	do	AUX
ijpds-3133	244	6	not	not	PART
ijpds-3133	244	7	find	find	VERB
ijpds-3133	244	8	any	any	DET
ijpds-3133	244	9	serious	serious	ADJ
ijpds-3133	244	10	adverse	adverse	ADJ
ijpds-3133	244	11	effects	effect	NOUN
ijpds-3133	244	12	and	and	CCONJ
ijpds-3133	244	13	showed	show	VERB
ijpds-3133	244	14	only	only	ADV
ijpds-3133	244	15	slightly	slightly	ADV
ijpds-3133	244	16	less	less	ADJ
ijpds-3133	244	17	hypotensive	hypotensive	ADJ
ijpds-3133	244	18	effects	effect	NOUN
ijpds-3133	244	19	as	as	SCONJ
ijpds-3133	244	20	compared	compare	VERB
ijpds-3133	244	21	with	with	ADP
ijpds-3133	244	22	timolol	timolol	NOUN
ijpds-3133	244	23	.	.	PUNCT
ijpds-3133	245	1	latanoprost	latanoprost	VERB
ijpds-3133	245	2	punctal	punctal	ADJ
ijpds-3133	245	3	plug	plug	NOUN
ijpds-3133	245	4	delivery	delivery	NOUN
ijpds-3133	245	5	systemgoldberg	systemgoldberg	PROPN
ijpds-3133	245	6	and	and	CCONJ
ijpds-3133	245	7	williams	williams	PROPN
ijpds-3133	246	1	[	[	X
ijpds-3133	246	2	74	74	NUM
ijpds-3133	246	3	]	]	PUNCT
ijpds-3133	246	4	used	use	VERB
ijpds-3133	246	5	the	the	DET
ijpds-3133	246	6	latanoprost	latanoprost	ADJ
ijpds-3133	246	7	punctal	punctal	ADJ
ijpds-3133	246	8	plug	plug	NOUN
ijpds-3133	246	9	delivery	delivery	NOUN
ijpds-3133	246	10	system	system	NOUN
ijpds-3133	246	11	(	(	PUNCT
ijpds-3133	246	12	l	l	NOUN
ijpds-3133	246	13	-	-	NOUN
ijpds-3133	246	14	ppds	ppds	NOUN
ijpds-3133	246	15	)	)	PUNCT
ijpds-3133	246	16	for	for	ADP
ijpds-3133	246	17	lowering	lower	VERB
ijpds-3133	246	18	iop	iop	NOUN
ijpds-3133	246	19	in	in	ADP
ijpds-3133	246	20	oag	oag	PROPN
ijpds-3133	246	21	patients	patient	NOUN
ijpds-3133	246	22	.	.	PUNCT
ijpds-3133	247	1	the	the	DET
ijpds-3133	247	2	data	datum	NOUN
ijpds-3133	247	3	reported	report	VERB
ijpds-3133	247	4	by	by	ADP
ijpds-3133	247	5	the	the	DET
ijpds-3133	247	6	authors	author	NOUN
ijpds-3133	247	7	showed	show	VERB
ijpds-3133	247	8	a	a	DET
ijpds-3133	247	9	reduction	reduction	NOUN
ijpds-3133	247	10	in	in	ADP
ijpds-3133	247	11	mean	mean	PROPN
ijpds-3133	247	12	iop	iop	NOUN
ijpds-3133	247	13	by	by	ADP
ijpds-3133	247	14	5.7	5.7	NUM
ijpds-3133	247	15	mmhg	mmhg	NOUN
ijpds-3133	247	16	.	.	PUNCT
ijpds-3133	248	1	they	they	PRON
ijpds-3133	248	2	also	also	ADV
ijpds-3133	248	3	reported	report	VERB
ijpds-3133	248	4	that	that	SCONJ
ijpds-3133	248	5	60	60	NUM
ijpds-3133	248	6	%	%	NOUN
ijpds-3133	248	7	of	of	ADP
ijpds-3133	248	8	subjects	subject	NOUN
ijpds-3133	248	9	in	in	ADP
ijpds-3133	248	10	the	the	DET
ijpds-3133	248	11	study	study	NOUN
ijpds-3133	248	12	showed	show	VERB
ijpds-3133	248	13	at	at	ADP
ijpds-3133	248	14	least	least	ADV
ijpds-3133	248	15	5	5	NUM
ijpds-3133	248	16	mmhg	mmhg	NOUN
ijpds-3133	248	17	or	or	CCONJ
ijpds-3133	248	18	higher	high	ADJ
ijpds-3133	248	19	iop	iop	NOUN
ijpds-3133	248	20	reduction	reduction	NOUN
ijpds-3133	248	21	,	,	PUNCT
ijpds-3133	248	22	and	and	CCONJ
ijpds-3133	248	23	47	47	NUM
ijpds-3133	248	24	%	%	NOUN
ijpds-3133	248	25	of	of	ADP
ijpds-3133	248	26	the	the	DET
ijpds-3133	248	27	subjects	subject	NOUN
ijpds-3133	248	28	showed	show	VERB
ijpds-3133	248	29	a	a	DET
ijpds-3133	248	30	reduction	reduction	NOUN
ijpds-3133	248	31	of	of	ADP
ijpds-3133	248	32	at	at	ADV
ijpds-3133	248	33	least	least	ADV
ijpds-3133	248	34	6	6	NUM
ijpds-3133	248	35	mmhg	mmhg	NOUN
ijpds-3133	248	36	.	.	PUNCT
ijpds-3133	249	1	a	a	DET
ijpds-3133	249	2	statistically	statistically	ADV
ijpds-3133	249	3	significant	significant	ADJ
ijpds-3133	249	4	22.3	22.3	NUM
ijpds-3133	249	5	%	%	NOUN
ijpds-3133	249	6	mean	mean	NOUN
ijpds-3133	249	7	change	change	NOUN
ijpds-3133	249	8	in	in	ADP
ijpds-3133	249	9	iop	iop	PROPN
ijpds-3133	249	10	was	be	AUX
ijpds-3133	249	11	recorded	record	VERB
ijpds-3133	249	12	in	in	ADP
ijpds-3133	249	13	the	the	DET
ijpds-3133	249	14	subjects	subject	NOUN
ijpds-3133	249	15	with	with	ADP
ijpds-3133	249	16	l	l	NOUN
ijpds-3133	249	17	-	-	NOUN
ijpds-3133	249	18	ppds	ppds	NOUN
ijpds-3133	249	19	when	when	SCONJ
ijpds-3133	249	20	compared	compare	VERB
ijpds-3133	249	21	with	with	ADP
ijpds-3133	249	22	controls	control	NOUN
ijpds-3133	249	23	.	.	PUNCT
ijpds-3133	250	1	evoluteevolute	evoluteevolute	NOUN
ijpds-3133	250	2	,	,	PUNCT
ijpds-3133	250	3	a	a	DET
ijpds-3133	250	4	punctal	punctal	ADJ
ijpds-3133	250	5	plug	plug	NOUN
ijpds-3133	250	6	delivery	delivery	NOUN
ijpds-3133	250	7	system	system	NOUN
ijpds-3133	250	8	developed	develop	VERB
ijpds-3133	250	9	by	by	ADP
ijpds-3133	250	10	mati	mati	PROPN
ijpds-3133	250	11	therapeutics	therapeutic	NOUN
ijpds-3133	250	12	has	have	AUX
ijpds-3133	250	13	been	be	AUX
ijpds-3133	250	14	tested	test	VERB
ijpds-3133	250	15	with	with	ADP
ijpds-3133	250	16	latanoprost	latanoprost	ADJ
ijpds-3133	250	17	in	in	ADP
ijpds-3133	250	18	patients	patient	NOUN
ijpds-3133	250	19	with	with	ADP
ijpds-3133	250	20	oag	oag	PROPN
ijpds-3133	250	21	or	or	CCONJ
ijpds-3133	250	22	ocular	ocular	ADJ
ijpds-3133	250	23	hypertension	hypertension	NOUN
ijpds-3133	250	24	[	[	X
ijpds-3133	250	25	75	75	NUM
ijpds-3133	250	26	]	]	PUNCT
ijpds-3133	250	27	.	.	PUNCT
ijpds-3133	251	1	the	the	DET
ijpds-3133	251	2	plug	plug	NOUN
ijpds-3133	251	3	consists	consist	VERB
ijpds-3133	251	4	of	of	ADP
ijpds-3133	251	5	a	a	DET
ijpds-3133	251	6	drug	drug	NOUN
ijpds-3133	251	7	core	core	NOUN
ijpds-3133	251	8	,	,	PUNCT
ijpds-3133	251	9	which	which	PRON
ijpds-3133	251	10	allows	allow	VERB
ijpds-3133	251	11	unidirectional	unidirectional	ADJ
ijpds-3133	251	12	sustained	sustained	ADJ
ijpds-3133	251	13	drug	drug	NOUN
ijpds-3133	251	14	elution	elution	NOUN
ijpds-3133	251	15	into	into	ADP
ijpds-3133	251	16	the	the	DET
ijpds-3133	251	17	tear	tear	ADJ
ijpds-3133	251	18	film	film	NOUN
ijpds-3133	251	19	.	.	PUNCT
ijpds-3133	252	1	in	in	ADP
ijpds-3133	252	2	phase	phase	NOUN
ijpds-3133	252	3	ii	ii	PROPN
ijpds-3133	252	4	clinical	clinical	ADJ
ijpds-3133	252	5	trial	trial	NOUN
ijpds-3133	252	6	,	,	PUNCT
ijpds-3133	252	7	an	an	DET
ijpds-3133	252	8	overall	overall	ADJ
ijpds-3133	252	9	punctal	punctal	ADJ
ijpds-3133	252	10	plug	plug	NOUN
ijpds-3133	252	11	retention	retention	NOUN
ijpds-3133	252	12	rate	rate	NOUN
ijpds-3133	252	13	of	of	ADP
ijpds-3133	252	14	96	96	NUM
ijpds-3133	252	15	%	%	NOUN
ijpds-3133	252	16	was	be	AUX
ijpds-3133	252	17	reported	report	VERB
ijpds-3133	252	18	at	at	ADP
ijpds-3133	252	19	12	12	NUM
ijpds-3133	252	20	weeks	week	NOUN
ijpds-3133	252	21	.	.	PUNCT
ijpds-3133	253	1	in	in	ADP
ijpds-3133	253	2	the	the	DET
ijpds-3133	253	3	second	second	ADJ
ijpds-3133	253	4	phase	phase	NOUN
ijpds-3133	253	5	,	,	PUNCT
ijpds-3133	253	6	the	the	DET
ijpds-3133	253	7	retention	retention	NOUN
ijpds-3133	253	8	rate	rate	NOUN
ijpds-3133	253	9	of	of	ADP
ijpds-3133	253	10	plugs	plug	NOUN
ijpds-3133	253	11	was	be	AUX
ijpds-3133	253	12	92	92	NUM
ijpds-3133	253	13	%	%	NOUN
ijpds-3133	253	14	in	in	ADP
ijpds-3133	253	15	the	the	DET
ijpds-3133	253	16	12th	12th	ADJ
ijpds-3133	253	17	week	week	NOUN
ijpds-3133	253	18	.	.	PUNCT
ijpds-3133	254	1	the	the	DET
ijpds-3133	254	2	punctal	punctal	ADJ
ijpds-3133	254	3	plugs	plug	NOUN
ijpds-3133	254	4	loaded	load	VERB
ijpds-3133	254	5	with	with	ADP
ijpds-3133	254	6	travoprost	travoprost	NOUN
ijpds-3133	254	7	reduced	reduce	VERB
ijpds-3133	254	8	the	the	DET
ijpds-3133	254	9	pressure	pressure	NOUN
ijpds-3133	254	10	by	by	ADP
ijpds-3133	254	11	7	7	NUM
ijpds-3133	254	12	mm	mm	NOUN
ijpds-3133	254	13	compared	compare	VERB
ijpds-3133	254	14	with	with	ADP
ijpds-3133	254	15	a	a	DET
ijpds-3133	254	16	5	5	NUM
ijpds-3133	254	17	-	-	PUNCT
ijpds-3133	254	18	mmhg	mmhg	NOUN
ijpds-3133	254	19	decreased	decrease	VERB
ijpds-3133	254	20	pressure	pressure	NOUN
ijpds-3133	254	21	with	with	ADP
ijpds-3133	254	22	latanoprost	latanoprost	ADJ
ijpds-3133	254	23	.	.	PUNCT
ijpds-3133	255	1	pentablock	pentablock	PROPN
ijpds-3133	255	2	copolymer	copolymer	PROPN
ijpds-3133	255	3	gelsthe	gelsthe	PROPN
ijpds-3133	255	4	pentablock	pentablock	NOUN
ijpds-3133	255	5	copolymer	copolymer	NOUN
ijpds-3133	255	6	gels	gel	NOUN
ijpds-3133	255	7	were	be	AUX
ijpds-3133	255	8	used	use	VERB
ijpds-3133	255	9	as	as	ADP
ijpds-3133	255	10	a	a	DET
ijpds-3133	255	11	vehicle	vehicle	NOUN
ijpds-3133	255	12	for	for	ADP
ijpds-3133	255	13	topical	topical	ADJ
ijpds-3133	255	14	and	and	CCONJ
ijpds-3133	255	15	intraocular	intraocular	ADJ
ijpds-3133	255	16	delivery	delivery	NOUN
ijpds-3133	255	17	of	of	ADP
ijpds-3133	255	18	glaucoma	glaucoma	NOUN
ijpds-3133	255	19	drugs	drug	NOUN
ijpds-3133	255	20	like	like	ADP
ijpds-3133	255	21	bimatoprost	bimatoprost	NOUN
ijpds-3133	255	22	.	.	PUNCT
ijpds-3133	256	1	the	the	DET
ijpds-3133	256	2	food	food	NOUN
ijpds-3133	256	3	and	and	CCONJ
ijpds-3133	256	4	drug	drug	PROPN
ijpds-3133	256	5	administration	administration	PROPN
ijpds-3133	256	6	(	(	PUNCT
ijpds-3133	256	7	fda	fda	PROPN
ijpds-3133	256	8	)	)	PUNCT
ijpds-3133	256	9	has	have	AUX
ijpds-3133	256	10	approved	approve	VERB
ijpds-3133	256	11	five	five	NUM
ijpds-3133	256	12	different	different	ADJ
ijpds-3133	256	13	pentablock	pentablock	NOUN
ijpds-3133	256	14	copolymers	copolymer	NOUN
ijpds-3133	256	15	for	for	ADP
ijpds-3133	256	16	use	use	NOUN
ijpds-3133	256	17	in	in	ADP
ijpds-3133	256	18	the	the	DET
ijpds-3133	256	19	eye	eye	NOUN
ijpds-3133	256	20	.	.	PUNCT
ijpds-3133	257	1	these	these	PRON
ijpds-3133	257	2	include	include	VERB
ijpds-3133	257	3	polyglycolic	polyglycolic	ADJ
ijpds-3133	257	4	acid	acid	NOUN
ijpds-3133	257	5	(	(	PUNCT
ijpds-3133	257	6	pga	pga	PROPN
ijpds-3133	257	7	)	)	PUNCT
ijpds-3133	257	8	,	,	PUNCT
ijpds-3133	257	9	pcl	pcl	PROPN
ijpds-3133	257	10	,	,	PUNCT
ijpds-3133	257	11	peg	peg	NOUN
ijpds-3133	257	12	,	,	PUNCT
ijpds-3133	257	13	pla	pla	NOUN
ijpds-3133	257	14	,	,	PUNCT
ijpds-3133	257	15	and	and	CCONJ
ijpds-3133	257	16	plga	plga	VERB
ijpds-3133	257	17	[	[	X
ijpds-3133	257	18	76	76	NUM
ijpds-3133	257	19	]	]	PUNCT
ijpds-3133	257	20	.	.	PUNCT
ijpds-3133	258	1	the	the	DET
ijpds-3133	258	2	drug	drug	NOUN
ijpds-3133	258	3	was	be	AUX
ijpds-3133	258	4	introduced	introduce	VERB
ijpds-3133	258	5	as	as	ADP
ijpds-3133	258	6	an	an	DET
ijpds-3133	258	7	eye	eye	NOUN
ijpds-3133	258	8	drop	drop	NOUN
ijpds-3133	258	9	,	,	PUNCT
ijpds-3133	258	10	then	then	ADV
ijpds-3133	258	11	changes	change	VERB
ijpds-3133	258	12	physical	physical	ADJ
ijpds-3133	258	13	characteristics	characteristic	NOUN
ijpds-3133	258	14	based	base	VERB
ijpds-3133	258	15	on	on	ADP
ijpds-3133	258	16	body	body	NOUN
ijpds-3133	258	17	temperature	temperature	NOUN
ijpds-3133	258	18	at	at	ADP
ijpds-3133	258	19	contact	contact	NOUN
ijpds-3133	258	20	.	.	PUNCT
ijpds-3133	259	1	the	the	DET
ijpds-3133	259	2	change	change	NOUN
ijpds-3133	259	3	in	in	ADP
ijpds-3133	259	4	viscosity	viscosity	NOUN
ijpds-3133	259	5	gives	give	VERB
ijpds-3133	259	6	the	the	DET
ijpds-3133	259	7	vehicle	vehicle	NOUN
ijpds-3133	259	8	copolymer	copolymer	NOUN
ijpds-3133	259	9	gel	gel	NOUN
ijpds-3133	259	10	-	-	PUNCT
ijpds-3133	259	11	like	like	ADJ
ijpds-3133	259	12	characteristics	characteristic	NOUN
ijpds-3133	259	13	gets	get	AUX
ijpds-3133	259	14	accumulated	accumulate	VERB
ijpds-3133	259	15	under	under	ADP
ijpds-3133	259	16	the	the	DET
ijpds-3133	259	17	lower	low	ADJ
ijpds-3133	259	18	palpebra	palpebra	NOUN
ijpds-3133	259	19	,	,	PUNCT
ijpds-3133	259	20	releasing	release	VERB
ijpds-3133	259	21	the	the	DET
ijpds-3133	259	22	drug	drug	NOUN
ijpds-3133	259	23	over	over	ADP
ijpds-3133	259	24	a	a	DET
ijpds-3133	259	25	longer	long	ADJ
ijpds-3133	259	26	period	period	NOUN
ijpds-3133	259	27	.	.	PUNCT
ijpds-3133	260	1	microneedlesmicroneedles	microneedlesmicroneedle	NOUN
ijpds-3133	260	2	are	be	AUX
ijpds-3133	260	3	drug	drug	NOUN
ijpds-3133	260	4	delivery	delivery	NOUN
ijpds-3133	260	5	devices	device	NOUN
ijpds-3133	260	6	manufactured	manufacture	VERB
ijpds-3133	260	7	using	use	VERB
ijpds-3133	260	8	metals	metal	NOUN
ijpds-3133	260	9	or	or	CCONJ
ijpds-3133	260	10	polymers	polymer	NOUN
ijpds-3133	260	11	with	with	ADP
ijpds-3133	260	12	dimensions	dimension	NOUN
ijpds-3133	260	13	between	between	ADP
ijpds-3133	260	14	10	10	NUM
ijpds-3133	260	15	and	and	CCONJ
ijpds-3133	260	16	200	200	NUM
ijpds-3133	260	17	μm	μm	NOUN
ijpds-3133	260	18	.	.	PUNCT
ijpds-3133	261	1	the	the	DET
ijpds-3133	261	2	ultra	ultra	ADJ
ijpds-3133	261	3	-	-	NOUN
ijpds-3133	261	4	dimensions	dimension	NOUN
ijpds-3133	261	5	of	of	ADP
ijpds-3133	261	6	these	these	DET
ijpds-3133	261	7	devices	device	NOUN
ijpds-3133	261	8	make	make	VERB
ijpds-3133	261	9	the	the	DET
ijpds-3133	261	10	drug	drug	NOUN
ijpds-3133	261	11	delivery	delivery	NOUN
ijpds-3133	261	12	less	less	ADV
ijpds-3133	261	13	invasive	invasive	ADJ
ijpds-3133	261	14	and	and	CCONJ
ijpds-3133	261	15	more	more	ADV
ijpds-3133	261	16	targeted	target	VERB
ijpds-3133	261	17	to	to	ADP
ijpds-3133	261	18	the	the	DET
ijpds-3133	261	19	sites	site	NOUN
ijpds-3133	261	20	of	of	ADP
ijpds-3133	261	21	drug	drug	NOUN
ijpds-3133	261	22	action	action	NOUN
ijpds-3133	261	23	.	.	PUNCT
ijpds-3133	262	1	jiang	jiang	PROPN
ijpds-3133	262	2	et	et	PROPN
ijpds-3133	262	3	al	al	PROPN
ijpds-3133	262	4	.	.	PROPN
ijpds-3133	262	5	used	use	VERB
ijpds-3133	262	6	500	500	NUM
ijpds-3133	262	7	to	to	PART
ijpds-3133	262	8	750	750	NUM
ijpds-3133	262	9	μm	μm	NOUN
ijpds-3133	262	10	longcoated	longcoate	VERB
ijpds-3133	262	11	stainless	stainless	ADJ
ijpds-3133	262	12	-	-	PUNCT
ijpds-3133	262	13	steel	steel	NOUN
ijpds-3133	262	14	microneedles	microneedle	NOUN
ijpds-3133	262	15	delivering	deliver	VERB
ijpds-3133	262	16	pilocarpine	pilocarpine	NOUN
ijpds-3133	262	17	into	into	ADP
ijpds-3133	262	18	the	the	DET
ijpds-3133	262	19	anterior	anterior	ADJ
ijpds-3133	262	20	chamber	chamber	NOUN
ijpds-3133	262	21	via	via	ADP
ijpds-3133	262	22	the	the	DET
ijpds-3133	262	23	intrascleral	intrascleral	ADJ
ijpds-3133	262	24	route	route	NOUN
ijpds-3133	262	25	.	.	PUNCT
ijpds-3133	263	1	the	the	DET
ijpds-3133	263	2	authors	author	NOUN
ijpds-3133	263	3	reported	report	VERB
ijpds-3133	263	4	a	a	DET
ijpds-3133	263	5	45	45	NUM
ijpds-3133	263	6	-	-	ADJ
ijpds-3133	263	7	fold	fold	ADJ
ijpds-3133	263	8	increase	increase	NOUN
ijpds-3133	263	9	in	in	ADP
ijpds-3133	263	10	drug	drug	NOUN
ijpds-3133	263	11	absorption	absorption	NOUN
ijpds-3133	263	12	compared	compare	VERB
ijpds-3133	263	13	with	with	ADP
ijpds-3133	263	14	conventional	conventional	ADJ
ijpds-3133	263	15	eye	eye	NOUN
ijpds-3133	263	16	drops	drop	NOUN
ijpds-3133	263	17	[	[	X
ijpds-3133	263	18	77	77	NUM
ijpds-3133	263	19	,	,	PUNCT
ijpds-3133	263	20	78	78	NUM
ijpds-3133	263	21	]	]	PUNCT
ijpds-3133	263	22	.	.	PUNCT
ijpds-3133	264	1	rai	rai	PROPN
ijpds-3133	264	2	et	et	PROPN
ijpds-3133	264	3	al	al	PROPN
ijpds-3133	264	4	mindful	mindful	ADJ
ijpds-3133	264	5	-	-	PUNCT
ijpds-3133	264	6	based	base	VERB
ijpds-3133	264	7	stress	stress	NOUN
ijpds-3133	264	8	reduction	reduction	NOUN
ijpds-3133	264	9	impact	impact	NOUN
ijpds-3133	264	10	vol	vol	NOUN
ijpds-3133	264	11	1	1	NUM
ijpds-3133	264	12	|	|	NOUN
ijpds-3133	264	13	issue	issue	NOUN
ijpds-3133	264	14	2	2	NUM
ijpds-3133	265	1	|	|	ADV
ijpds-3133	265	2	jul	jul	PROPN
ijpds-3133	265	3	–	–	PUNCT
ijpds-3133	265	4	sep	sep	PROPN
ijpds-3133	265	5	2022	2022	NUM
ijpds-3133	266	1	indian	indian	PROPN
ijpds-3133	266	2	j	j	PROPN
ijpds-3133	266	3	pharm	pharm	PROPN
ijpds-3133	266	4	drug	drug	PROPN
ijpds-3133	266	5	studies	study	NOUN
ijpds-3133	266	6	|	|	ADV
ijpds-3133	266	7	44	44	NUM
ijpds-3133	266	8	discussion	discussion	NOUN
ijpds-3133	266	9	in	in	ADP
ijpds-3133	266	10	this	this	DET
ijpds-3133	266	11	review	review	NOUN
ijpds-3133	266	12	article	article	NOUN
ijpds-3133	266	13	,	,	PUNCT
ijpds-3133	266	14	we	we	PRON
ijpds-3133	266	15	described	describe	VERB
ijpds-3133	266	16	the	the	DET
ijpds-3133	266	17	development	development	NOUN
ijpds-3133	266	18	of	of	ADP
ijpds-3133	266	19	welltolerated	welltolerate	VERB
ijpds-3133	266	20	drug	drug	NOUN
ijpds-3133	266	21	delivery	delivery	NOUN
ijpds-3133	266	22	systems	system	NOUN
ijpds-3133	266	23	that	that	PRON
ijpds-3133	266	24	helps	help	VERB
ijpds-3133	266	25	to	to	PART
ijpds-3133	266	26	overcome	overcome	VERB
ijpds-3133	266	27	the	the	DET
ijpds-3133	266	28	factors	factor	NOUN
ijpds-3133	266	29	limiting	limit	VERB
ijpds-3133	266	30	adequate	adequate	ADJ
ijpds-3133	266	31	drug	drug	NOUN
ijpds-3133	266	32	delivery	delivery	NOUN
ijpds-3133	266	33	to	to	ADP
ijpds-3133	266	34	the	the	DET
ijpds-3133	266	35	glaucomatous	glaucomatous	ADJ
ijpds-3133	266	36	patients	patient	NOUN
ijpds-3133	266	37	targeting	target	VERB
ijpds-3133	266	38	infected	infect	VERB
ijpds-3133	266	39	tissues	tissue	NOUN
ijpds-3133	266	40	with	with	ADP
ijpds-3133	266	41	traditional	traditional	ADJ
ijpds-3133	266	42	techniques	technique	NOUN
ijpds-3133	266	43	.	.	PUNCT
ijpds-3133	267	1	ocusert	ocusert	PROPN
ijpds-3133	267	2	did	do	AUX
ijpds-3133	267	3	not	not	PART
ijpds-3133	267	4	become	become	VERB
ijpds-3133	267	5	a	a	DET
ijpds-3133	267	6	widely	widely	ADV
ijpds-3133	267	7	accepted	accept	VERB
ijpds-3133	267	8	method	method	NOUN
ijpds-3133	267	9	of	of	ADP
ijpds-3133	267	10	drug	drug	NOUN
ijpds-3133	267	11	delivery	delivery	NOUN
ijpds-3133	267	12	although	although	SCONJ
ijpds-3133	267	13	the	the	DET
ijpds-3133	267	14	clinical	clinical	ADJ
ijpds-3133	267	15	studies	study	NOUN
ijpds-3133	267	16	showed	show	VERB
ijpds-3133	267	17	positive	positive	ADJ
ijpds-3133	267	18	outcomes	outcome	NOUN
ijpds-3133	267	19	the	the	DET
ijpds-3133	267	20	difficulty	difficulty	NOUN
ijpds-3133	267	21	of	of	ADP
ijpds-3133	267	22	device	device	NOUN
ijpds-3133	267	23	insertion	insertion	NOUN
ijpds-3133	267	24	,	,	PUNCT
ijpds-3133	267	25	failure	failure	NOUN
ijpds-3133	267	26	in	in	ADP
ijpds-3133	267	27	satisfactorily	satisfactorily	ADV
ijpds-3133	267	28	controlling	control	VERB
ijpds-3133	267	29	iop	iop	NOUN
ijpds-3133	267	30	in	in	ADP
ijpds-3133	267	31	many	many	ADJ
ijpds-3133	267	32	patients	patient	NOUN
ijpds-3133	267	33	,	,	PUNCT
ijpds-3133	267	34	ejection	ejection	NOUN
ijpds-3133	267	35	of	of	ADP
ijpds-3133	267	36	the	the	DET
ijpds-3133	267	37	device	device	NOUN
ijpds-3133	267	38	from	from	ADP
ijpds-3133	267	39	the	the	DET
ijpds-3133	267	40	eye	eye	NOUN
ijpds-3133	267	41	,	,	PUNCT
ijpds-3133	267	42	irritation	irritation	NOUN
ijpds-3133	267	43	during	during	ADP
ijpds-3133	267	44	insertion	insertion	NOUN
ijpds-3133	267	45	,	,	PUNCT
ijpds-3133	267	46	and	and	CCONJ
ijpds-3133	267	47	the	the	DET
ijpds-3133	267	48	difficulty	difficulty	NOUN
ijpds-3133	267	49	in	in	ADP
ijpds-3133	267	50	device	device	NOUN
ijpds-3133	267	51	insertion	insertion	NOUN
ijpds-3133	267	52	[	[	X
ijpds-3133	267	53	14	14	NUM
ijpds-3133	267	54	]	]	PUNCT
ijpds-3133	267	55	.	.	PUNCT
ijpds-3133	268	1	the	the	DET
ijpds-3133	268	2	ease	ease	NOUN
ijpds-3133	268	3	of	of	ADP
ijpds-3133	268	4	availability	availability	NOUN
ijpds-3133	268	5	and	and	CCONJ
ijpds-3133	268	6	application	application	NOUN
ijpds-3133	268	7	of	of	ADP
ijpds-3133	268	8	therapeutic	therapeutic	ADJ
ijpds-3133	268	9	contact	contact	NOUN
ijpds-3133	268	10	lenses	lense	NOUN
ijpds-3133	268	11	make	make	VERB
ijpds-3133	268	12	them	they	PRON
ijpds-3133	268	13	an	an	DET
ijpds-3133	268	14	ideal	ideal	ADJ
ijpds-3133	268	15	drug	drug	NOUN
ijpds-3133	268	16	delivery	delivery	NOUN
ijpds-3133	268	17	system	system	NOUN
ijpds-3133	268	18	.	.	PUNCT
ijpds-3133	269	1	the	the	DET
ijpds-3133	269	2	therapeutic	therapeutic	ADJ
ijpds-3133	269	3	contact	contact	NOUN
ijpds-3133	269	4	lenses	lense	NOUN
ijpds-3133	269	5	help	help	VERB
ijpds-3133	269	6	in	in	ADP
ijpds-3133	269	7	sustained	sustained	ADJ
ijpds-3133	269	8	and	and	CCONJ
ijpds-3133	269	9	regulated	regulate	VERB
ijpds-3133	269	10	ocular	ocular	ADJ
ijpds-3133	269	11	drug	drug	NOUN
ijpds-3133	269	12	delivery	delivery	NOUN
ijpds-3133	269	13	due	due	ADP
ijpds-3133	269	14	to	to	ADP
ijpds-3133	269	15	their	their	PRON
ijpds-3133	269	16	unique	unique	ADJ
ijpds-3133	269	17	properties	property	NOUN
ijpds-3133	269	18	like	like	ADP
ijpds-3133	269	19	extended	extend	VERB
ijpds-3133	269	20	wear	wear	NOUN
ijpds-3133	269	21	and	and	CCONJ
ijpds-3133	269	22	more	more	ADJ
ijpds-3133	269	23	than	than	ADP
ijpds-3133	269	24	50	50	NUM
ijpds-3133	269	25	%	%	NOUN
ijpds-3133	269	26	bioavailability	bioavailability	NOUN
ijpds-3133	269	27	comparison	comparison	NOUN
ijpds-3133	269	28	with	with	ADP
ijpds-3133	269	29	eye	eye	NOUN
ijpds-3133	269	30	drop	drop	NOUN
ijpds-3133	269	31	formulations	formulation	NOUN
ijpds-3133	269	32	[	[	X
ijpds-3133	269	33	27	27	NUM
ijpds-3133	269	34	,	,	PUNCT
ijpds-3133	269	35	28	28	NUM
ijpds-3133	269	36	]	]	PUNCT
ijpds-3133	269	37	.	.	PUNCT
ijpds-3133	270	1	soft	soft	ADJ
ijpds-3133	270	2	contact	contact	NOUN
ijpds-3133	270	3	lenses	lense	NOUN
ijpds-3133	270	4	are	be	AUX
ijpds-3133	270	5	water	water	NOUN
ijpds-3133	270	6	-	-	PUNCT
ijpds-3133	270	7	soluble	soluble	ADJ
ijpds-3133	270	8	polymeric	polymeric	ADJ
ijpds-3133	270	9	hydrogels	hydrogel	NOUN
ijpds-3133	270	10	crosslinked	crosslinke	VERB
ijpds-3133	270	11	to	to	PART
ijpds-3133	270	12	form	form	VERB
ijpds-3133	270	13	networks	network	NOUN
ijpds-3133	270	14	.	.	PUNCT
ijpds-3133	271	1	these	these	DET
ijpds-3133	271	2	hydrogel	hydrogel	NOUN
ijpds-3133	271	3	lenses	lense	NOUN
ijpds-3133	271	4	are	be	AUX
ijpds-3133	271	5	widely	widely	ADV
ijpds-3133	271	6	used	use	VERB
ijpds-3133	271	7	for	for	ADP
ijpds-3133	271	8	drug	drug	NOUN
ijpds-3133	271	9	delivery	delivery	NOUN
ijpds-3133	271	10	,	,	PUNCT
ijpds-3133	271	11	even	even	ADV
ijpds-3133	271	12	though	though	SCONJ
ijpds-3133	271	13	the	the	DET
ijpds-3133	271	14	delivery	delivery	NOUN
ijpds-3133	271	15	of	of	ADP
ijpds-3133	271	16	watersoluble	watersoluble	ADJ
ijpds-3133	271	17	drugs	drug	NOUN
ijpds-3133	271	18	,	,	PUNCT
ijpds-3133	271	19	such	such	ADJ
ijpds-3133	271	20	as	as	ADP
ijpds-3133	271	21	timolol	timolol	NOUN
ijpds-3133	271	22	and	and	CCONJ
ijpds-3133	271	23	dorzolamide	dorzolamide	NOUN
ijpds-3133	271	24	,	,	PUNCT
ijpds-3133	271	25	elutes	elute	VERB
ijpds-3133	271	26	from	from	ADP
ijpds-3133	271	27	the	the	DET
ijpds-3133	271	28	highly	highly	ADV
ijpds-3133	271	29	hydrated	hydrated	ADJ
ijpds-3133	271	30	polymer	polymer	NOUN
ijpds-3133	271	31	networks	network	NOUN
ijpds-3133	271	32	rapidly	rapidly	ADV
ijpds-3133	271	33	[	[	X
ijpds-3133	271	34	29	29	NUM
ijpds-3133	271	35	]	]	PUNCT
ijpds-3133	271	36	.	.	PUNCT
ijpds-3133	272	1	in	in	ADP
ijpds-3133	272	2	comparison	comparison	NOUN
ijpds-3133	272	3	,	,	PUNCT
ijpds-3133	272	4	the	the	DET
ijpds-3133	272	5	soft	soft	ADJ
ijpds-3133	272	6	contact	contact	NOUN
ijpds-3133	272	7	lenses	lense	NOUN
ijpds-3133	272	8	manufactured	manufacture	VERB
ijpds-3133	272	9	by	by	ADP
ijpds-3133	272	10	polymerization	polymerization	NOUN
ijpds-3133	272	11	n	n	CCONJ
ijpds-3133	272	12	,	,	PUNCT
ijpds-3133	272	13	n	n	CCONJ
ijpds-3133	272	14	-	-	PUNCT
ijpds-3133	272	15	diethyl	diethyl	NOUN
ijpds-3133	272	16	acrylamide	acrylamide	NOUN
ijpds-3133	272	17	methacrylic	methacrylic	NOUN
ijpds-3133	272	18	acid	acid	NOUN
ijpds-3133	272	19	deliver	deliver	VERB
ijpds-3133	272	20	timolol	timolol	NOUN
ijpds-3133	272	21	over	over	ADP
ijpds-3133	272	22	a	a	DET
ijpds-3133	272	23	prolonged	prolonged	ADJ
ijpds-3133	272	24	period	period	NOUN
ijpds-3133	272	25	[	[	X
ijpds-3133	272	26	30	30	NUM
ijpds-3133	272	27	]	]	PUNCT
ijpds-3133	272	28	.	.	PUNCT
ijpds-3133	273	1	injectable	injectable	ADJ
ijpds-3133	273	2	systems	system	NOUN
ijpds-3133	273	3	are	be	AUX
ijpds-3133	273	4	passive	passive	ADJ
ijpds-3133	273	5	delivery	delivery	NOUN
ijpds-3133	273	6	systems	system	NOUN
ijpds-3133	273	7	capable	capable	ADJ
ijpds-3133	273	8	of	of	ADP
ijpds-3133	273	9	delivering	deliver	VERB
ijpds-3133	273	10	medications	medication	NOUN
ijpds-3133	273	11	to	to	ADP
ijpds-3133	273	12	the	the	DET
ijpds-3133	273	13	target	target	NOUN
ijpds-3133	273	14	tissues	tissue	NOUN
ijpds-3133	273	15	for	for	ADP
ijpds-3133	273	16	an	an	DET
ijpds-3133	273	17	extended	extended	ADJ
ijpds-3133	273	18	period	period	NOUN
ijpds-3133	273	19	.	.	PUNCT
ijpds-3133	274	1	the	the	DET
ijpds-3133	274	2	injectable	injectable	ADJ
ijpds-3133	274	3	systems	system	NOUN
ijpds-3133	274	4	are	be	AUX
ijpds-3133	274	5	typically	typically	ADV
ijpds-3133	274	6	implanted	implant	VERB
ijpds-3133	274	7	at	at	ADP
ijpds-3133	274	8	the	the	DET
ijpds-3133	274	9	site	site	NOUN
ijpds-3133	274	10	of	of	ADP
ijpds-3133	274	11	drug	drug	NOUN
ijpds-3133	274	12	release	release	NOUN
ijpds-3133	274	13	through	through	ADP
ijpds-3133	274	14	a	a	DET
ijpds-3133	274	15	minimally	minimally	ADV
ijpds-3133	274	16	invasive	invasive	ADJ
ijpds-3133	274	17	procedure	procedure	NOUN
ijpds-3133	274	18	,	,	PUNCT
ijpds-3133	274	19	usually	usually	ADV
ijpds-3133	274	20	in	in	ADP
ijpds-3133	274	21	an	an	DET
ijpds-3133	274	22	outpatient	outpatient	NOUN
ijpds-3133	274	23	setting	setting	NOUN
ijpds-3133	274	24	.	.	PUNCT
ijpds-3133	275	1	the	the	DET
ijpds-3133	275	2	injectable	injectable	ADJ
ijpds-3133	275	3	systems	system	NOUN
ijpds-3133	275	4	use	use	VERB
ijpds-3133	275	5	a	a	DET
ijpds-3133	275	6	polymer	polymer	NOUN
ijpds-3133	275	7	delivery	delivery	NOUN
ijpds-3133	275	8	vehicle	vehicle	NOUN
ijpds-3133	275	9	to	to	PART
ijpds-3133	275	10	prolong	prolong	VERB
ijpds-3133	275	11	delivery	delivery	NOUN
ijpds-3133	275	12	up	up	ADP
ijpds-3133	275	13	to	to	ADP
ijpds-3133	275	14	a	a	DET
ijpds-3133	275	15	few	few	ADJ
ijpds-3133	275	16	months	month	NOUN
ijpds-3133	275	17	around	around	ADP
ijpds-3133	275	18	the	the	DET
ijpds-3133	275	19	surrounding	surround	VERB
ijpds-3133	275	20	tissue	tissue	NOUN
ijpds-3133	275	21	.	.	PUNCT
ijpds-3133	276	1	both	both	CCONJ
ijpds-3133	276	2	degradable	degradable	ADJ
ijpds-3133	276	3	and	and	CCONJ
ijpds-3133	276	4	non	non	ADJ
ijpds-3133	276	5	-	-	ADJ
ijpds-3133	276	6	degradable	degradable	ADJ
ijpds-3133	276	7	polymers	polymer	NOUN
ijpds-3133	276	8	have	have	AUX
ijpds-3133	276	9	been	be	AUX
ijpds-3133	276	10	developed	develop	VERB
ijpds-3133	276	11	used	use	VERB
ijpds-3133	276	12	as	as	ADP
ijpds-3133	276	13	injectable	injectable	ADJ
ijpds-3133	276	14	systems	system	NOUN
ijpds-3133	276	15	for	for	ADP
ijpds-3133	276	16	drug	drug	NOUN
ijpds-3133	276	17	delivery	delivery	NOUN
ijpds-3133	276	18	in	in	ADP
ijpds-3133	276	19	the	the	DET
ijpds-3133	276	20	eye	eye	NOUN
ijpds-3133	277	1	[	[	X
ijpds-3133	277	2	65	65	NUM
ijpds-3133	277	3	]	]	PUNCT
ijpds-3133	277	4	.	.	PUNCT
ijpds-3133	278	1	degradable	degradable	ADJ
ijpds-3133	278	2	plgas	plgas	NOUN
ijpds-3133	278	3	are	be	AUX
ijpds-3133	278	4	materials	material	NOUN
ijpds-3133	278	5	of	of	ADP
ijpds-3133	278	6	choice	choice	NOUN
ijpds-3133	278	7	for	for	ADP
ijpds-3133	278	8	developing	develop	VERB
ijpds-3133	278	9	such	such	DET
ijpds-3133	278	10	a	a	DET
ijpds-3133	278	11	system	system	NOUN
ijpds-3133	278	12	.	.	PUNCT
ijpds-3133	279	1	the	the	DET
ijpds-3133	279	2	non	non	ADJ
ijpds-3133	279	3	-	-	ADJ
ijpds-3133	279	4	degradable	degradable	ADJ
ijpds-3133	279	5	alternative	alternative	NOUN
ijpds-3133	279	6	such	such	ADJ
ijpds-3133	279	7	as	as	ADP
ijpds-3133	279	8	the	the	DET
ijpds-3133	279	9	polymer	polymer	NOUN
ijpds-3133	279	10	of	of	ADP
ijpds-3133	279	11	ethylene	ethylene	NOUN
ijpds-3133	279	12	-	-	PUNCT
ijpds-3133	279	13	co	co	NOUN
ijpds-3133	279	14	-	-	ADJ
ijpds-3133	279	15	vinyl	vinyl	ADJ
ijpds-3133	279	16	acetate	acetate	NOUN
ijpds-3133	279	17	may	may	AUX
ijpds-3133	279	18	lead	lead	VERB
ijpds-3133	279	19	to	to	ADP
ijpds-3133	279	20	an	an	DET
ijpds-3133	279	21	immune	immune	ADJ
ijpds-3133	279	22	response	response	NOUN
ijpds-3133	279	23	due	due	ADP
ijpds-3133	279	24	to	to	ADP
ijpds-3133	279	25	the	the	DET
ijpds-3133	279	26	prolonged	prolonged	ADJ
ijpds-3133	279	27	presence	presence	NOUN
ijpds-3133	279	28	of	of	ADP
ijpds-3133	279	29	a	a	DET
ijpds-3133	279	30	foreign	foreign	ADJ
ijpds-3133	279	31	body	body	NOUN
ijpds-3133	279	32	[	[	X
ijpds-3133	279	33	66	66	NUM
ijpds-3133	279	34	]	]	PUNCT
ijpds-3133	279	35	.	.	PUNCT
ijpds-3133	280	1	the	the	DET
ijpds-3133	280	2	rate	rate	NOUN
ijpds-3133	280	3	of	of	ADP
ijpds-3133	280	4	dispersion	dispersion	NOUN
ijpds-3133	280	5	of	of	ADP
ijpds-3133	280	6	drugs	drug	NOUN
ijpds-3133	280	7	from	from	ADP
ijpds-3133	280	8	these	these	DET
ijpds-3133	280	9	systems	system	NOUN
ijpds-3133	280	10	is	be	AUX
ijpds-3133	280	11	variable	variable	ADJ
ijpds-3133	280	12	,	,	PUNCT
ijpds-3133	280	13	with	with	ADP
ijpds-3133	280	14	an	an	DET
ijpds-3133	280	15	initially	initially	ADV
ijpds-3133	280	16	more	more	ADV
ijpds-3133	280	17	massive	massive	ADJ
ijpds-3133	280	18	quantity	quantity	NOUN
ijpds-3133	280	19	release	release	NOUN
ijpds-3133	280	20	.	.	PUNCT
ijpds-3133	281	1	the	the	DET
ijpds-3133	281	2	water	water	NOUN
ijpds-3133	281	3	solubility	solubility	NOUN
ijpds-3133	281	4	of	of	ADP
ijpds-3133	281	5	the	the	DET
ijpds-3133	281	6	drug	drug	NOUN
ijpds-3133	281	7	affects	affect	VERB
ijpds-3133	281	8	the	the	DET
ijpds-3133	281	9	efficacy	efficacy	NOUN
ijpds-3133	281	10	because	because	SCONJ
ijpds-3133	281	11	hydrophilic	hydrophilic	ADJ
ijpds-3133	281	12	drugs	drug	NOUN
ijpds-3133	281	13	interact	interact	VERB
ijpds-3133	281	14	poorly	poorly	ADV
ijpds-3133	281	15	with	with	ADP
ijpds-3133	281	16	degradable	degradable	ADJ
ijpds-3133	281	17	polymers	polymer	NOUN
ijpds-3133	281	18	as	as	SCONJ
ijpds-3133	281	19	they	they	PRON
ijpds-3133	281	20	are	be	AUX
ijpds-3133	281	21	hydrophobic	hydrophobic	ADJ
ijpds-3133	281	22	[	[	X
ijpds-3133	281	23	67	67	NUM
ijpds-3133	281	24	]	]	PUNCT
ijpds-3133	281	25	.	.	PUNCT
ijpds-3133	282	1	several	several	ADJ
ijpds-3133	282	2	methods	method	NOUN
ijpds-3133	282	3	of	of	ADP
ijpds-3133	282	4	treatment	treatment	NOUN
ijpds-3133	282	5	of	of	ADP
ijpds-3133	282	6	glaucoma	glaucoma	NOUN
ijpds-3133	282	7	in	in	ADP
ijpds-3133	282	8	the	the	DET
ijpds-3133	282	9	patient	patient	NOUN
ijpds-3133	282	10	’s	’s	PART
ijpds-3133	282	11	eye	eye	NOUN
ijpds-3133	282	12	were	be	AUX
ijpds-3133	282	13	discussed	discuss	VERB
ijpds-3133	282	14	in	in	ADP
ijpds-3133	282	15	this	this	DET
ijpds-3133	282	16	review	review	NOUN
ijpds-3133	282	17	and	and	CCONJ
ijpds-3133	282	18	also	also	ADV
ijpds-3133	282	19	,	,	PUNCT
ijpds-3133	282	20	we	we	PRON
ijpds-3133	282	21	discussed	discuss	VERB
ijpds-3133	282	22	the	the	DET
ijpds-3133	282	23	development	development	NOUN
ijpds-3133	282	24	of	of	ADP
ijpds-3133	282	25	the	the	DET
ijpds-3133	282	26	well	well	ADV
ijpds-3133	282	27	-	-	PUNCT
ijpds-3133	282	28	tolerated	tolerate	VERB
ijpds-3133	282	29	drug	drug	NOUN
ijpds-3133	282	30	delivery	delivery	NOUN
ijpds-3133	282	31	systems	system	NOUN
ijpds-3133	282	32	that	that	PRON
ijpds-3133	282	33	helps	help	VERB
ijpds-3133	282	34	to	to	PART
ijpds-3133	282	35	overcome	overcome	VERB
ijpds-3133	282	36	the	the	DET
ijpds-3133	282	37	limiting	limit	VERB
ijpds-3133	282	38	factor	factor	NOUN
ijpds-3133	282	39	of	of	ADP
ijpds-3133	282	40	adequate	adequate	ADJ
ijpds-3133	282	41	drug	drug	NOUN
ijpds-3133	282	42	delivery	delivery	NOUN
ijpds-3133	282	43	systems	system	NOUN
ijpds-3133	282	44	.	.	PUNCT
ijpds-3133	283	1	in	in	ADP
ijpds-3133	283	2	the	the	DET
ijpds-3133	283	3	past	past	NOUN
ijpds-3133	283	4	,	,	PUNCT
ijpds-3133	283	5	many	many	ADJ
ijpds-3133	283	6	studies	study	NOUN
ijpds-3133	283	7	have	have	AUX
ijpds-3133	283	8	emphasized	emphasize	VERB
ijpds-3133	283	9	the	the	DET
ijpds-3133	283	10	importance	importance	NOUN
ijpds-3133	283	11	of	of	ADP
ijpds-3133	283	12	adherence	adherence	NOUN
ijpds-3133	283	13	,	,	PUNCT
ijpds-3133	283	14	compliance	compliance	NOUN
ijpds-3133	283	15	,	,	PUNCT
ijpds-3133	283	16	and	and	CCONJ
ijpds-3133	283	17	persistence	persistence	NOUN
ijpds-3133	283	18	for	for	ADP
ijpds-3133	283	19	the	the	DET
ijpds-3133	283	20	management	management	NOUN
ijpds-3133	283	21	of	of	ADP
ijpds-3133	283	22	glaucoma	glaucoma	NOUN
ijpds-3133	283	23	.	.	PUNCT
ijpds-3133	284	1	we	we	PRON
ijpds-3133	284	2	know	know	VERB
ijpds-3133	284	3	the	the	DET
ijpds-3133	284	4	available	available	ADJ
ijpds-3133	284	5	drugs	drug	NOUN
ijpds-3133	284	6	are	be	AUX
ijpds-3133	284	7	efficacious	efficacious	ADJ
ijpds-3133	284	8	in	in	ADP
ijpds-3133	284	9	lowering	lower	VERB
ijpds-3133	284	10	iop	iop	NOUN
ijpds-3133	284	11	and	and	CCONJ
ijpds-3133	284	12	neuroprotection	neuroprotection	NOUN
ijpds-3133	284	13	,	,	PUNCT
ijpds-3133	284	14	the	the	DET
ijpds-3133	284	15	traditional	traditional	ADJ
ijpds-3133	284	16	methods	method	NOUN
ijpds-3133	284	17	of	of	ADP
ijpds-3133	284	18	topical	topical	ADJ
ijpds-3133	284	19	drug	drug	NOUN
ijpds-3133	284	20	delivery	delivery	NOUN
ijpds-3133	284	21	have	have	AUX
ijpds-3133	284	22	been	be	AUX
ijpds-3133	284	23	not	not	PART
ijpds-3133	284	24	satisfactory	satisfactory	ADJ
ijpds-3133	284	25	due	due	ADP
ijpds-3133	284	26	to	to	ADP
ijpds-3133	284	27	poor	poor	ADJ
ijpds-3133	284	28	target	target	NOUN
ijpds-3133	284	29	bioavailability	bioavailability	NOUN
ijpds-3133	284	30	,	,	PUNCT
ijpds-3133	284	31	increased	increase	VERB
ijpds-3133	284	32	systemic	systemic	ADJ
ijpds-3133	284	33	absorption	absorption	NOUN
ijpds-3133	284	34	,	,	PUNCT
ijpds-3133	284	35	and	and	CCONJ
ijpds-3133	284	36	poor	poor	ADJ
ijpds-3133	284	37	patient	patient	ADJ
ijpds-3133	284	38	compliance	compliance	NOUN
ijpds-3133	284	39	.	.	PUNCT
ijpds-3133	285	1	conclusion	conclusion	NOUN
ijpds-3133	285	2	this	this	DET
ijpds-3133	285	3	review	review	NOUN
ijpds-3133	285	4	described	describe	VERB
ijpds-3133	285	5	the	the	DET
ijpds-3133	285	6	direction	direction	NOUN
ijpds-3133	285	7	and	and	CCONJ
ijpds-3133	285	8	ongoing	ongoing	ADJ
ijpds-3133	285	9	innovation	innovation	NOUN
ijpds-3133	285	10	/	/	SYM
ijpds-3133	285	11	research	research	NOUN
ijpds-3133	285	12	to	to	PART
ijpds-3133	285	13	address	address	VERB
ijpds-3133	285	14	the	the	DET
ijpds-3133	285	15	challenges	challenge	NOUN
ijpds-3133	285	16	of	of	ADP
ijpds-3133	285	17	safer	safe	ADJ
ijpds-3133	285	18	and	and	CCONJ
ijpds-3133	285	19	more	more	ADV
ijpds-3133	285	20	effective	effective	ADJ
ijpds-3133	285	21	drug	drug	NOUN
ijpds-3133	285	22	delivery	delivery	NOUN
ijpds-3133	285	23	challenges	challenge	NOUN
ijpds-3133	285	24	associated	associate	VERB
ijpds-3133	285	25	with	with	ADP
ijpds-3133	285	26	the	the	DET
ijpds-3133	285	27	previous	previous	ADJ
ijpds-3133	285	28	one	one	NUM
ijpds-3133	285	29	.	.	PUNCT
ijpds-3133	286	1	the	the	DET
ijpds-3133	286	2	majority	majority	NOUN
ijpds-3133	286	3	of	of	ADP
ijpds-3133	286	4	the	the	DET
ijpds-3133	286	5	devices	device	NOUN
ijpds-3133	286	6	studied	study	VERB
ijpds-3133	286	7	in	in	ADP
ijpds-3133	286	8	this	this	DET
ijpds-3133	286	9	article	article	NOUN
ijpds-3133	286	10	are	be	AUX
ijpds-3133	286	11	currently	currently	ADV
ijpds-3133	286	12	in	in	ADP
ijpds-3133	286	13	various	various	ADJ
ijpds-3133	286	14	stages	stage	NOUN
ijpds-3133	286	15	of	of	ADP
ijpds-3133	286	16	development	development	NOUN
ijpds-3133	286	17	and	and	CCONJ
ijpds-3133	286	18	are	be	AUX
ijpds-3133	286	19	not	not	PART
ijpds-3133	286	20	commercially	commercially	ADV
ijpds-3133	286	21	available	available	ADJ
ijpds-3133	286	22	.	.	PUNCT
ijpds-3133	287	1	the	the	DET
ijpds-3133	287	2	impact	impact	NOUN
ijpds-3133	287	3	of	of	ADP
ijpds-3133	287	4	these	these	DET
ijpds-3133	287	5	devices	device	NOUN
ijpds-3133	287	6	on	on	ADP
ijpds-3133	287	7	the	the	DET
ijpds-3133	287	8	patients	patient	NOUN
ijpds-3133	287	9	can	can	AUX
ijpds-3133	287	10	only	only	ADV
ijpds-3133	287	11	be	be	AUX
ijpds-3133	287	12	gauged	gauge	VERB
ijpds-3133	287	13	once	once	SCONJ
ijpds-3133	287	14	they	they	PRON
ijpds-3133	287	15	are	be	AUX
ijpds-3133	287	16	available	available	ADJ
ijpds-3133	287	17	for	for	ADP
ijpds-3133	287	18	clinical	clinical	ADJ
ijpds-3133	287	19	use	use	NOUN
ijpds-3133	287	20	and	and	CCONJ
ijpds-3133	287	21	extensive	extensive	ADJ
ijpds-3133	287	22	clinical	clinical	ADJ
ijpds-3133	287	23	data	datum	NOUN
ijpds-3133	287	24	are	be	AUX
ijpds-3133	287	25	available	available	ADJ
ijpds-3133	287	26	for	for	ADP
ijpds-3133	287	27	scrutiny	scrutiny	NOUN
ijpds-3133	287	28	.	.	PUNCT
ijpds-3133	288	1	notwithstanding	notwithstanding	ADP
ijpds-3133	288	2	the	the	DET
ijpds-3133	288	3	lack	lack	NOUN
ijpds-3133	288	4	of	of	ADP
ijpds-3133	288	5	data	datum	NOUN
ijpds-3133	288	6	,	,	PUNCT
ijpds-3133	288	7	the	the	DET
ijpds-3133	288	8	critical	critical	ADJ
ijpds-3133	288	9	role	role	NOUN
ijpds-3133	288	10	of	of	ADP
ijpds-3133	288	11	these	these	DET
ijpds-3133	288	12	devices	device	NOUN
ijpds-3133	288	13	in	in	ADP
ijpds-3133	288	14	glaucoma	glaucoma	NOUN
ijpds-3133	288	15	management	management	NOUN
ijpds-3133	288	16	shortly	shortly	ADV
ijpds-3133	288	17	needs	need	VERB
ijpds-3133	288	18	to	to	PART
ijpds-3133	288	19	be	be	AUX
ijpds-3133	288	20	emphasized	emphasize	VERB
ijpds-3133	288	21	.	.	PUNCT
ijpds-3133	289	1	the	the	DET
ijpds-3133	289	2	potential	potential	NOUN
ijpds-3133	289	3	of	of	ADP
ijpds-3133	289	4	increasing	increase	VERB
ijpds-3133	289	5	patient	patient	ADJ
ijpds-3133	289	6	compliance	compliance	NOUN
ijpds-3133	289	7	and	and	CCONJ
ijpds-3133	289	8	persistence	persistence	NOUN
ijpds-3133	289	9	for	for	ADP
ijpds-3133	289	10	optimum	optimum	ADJ
ijpds-3133	289	11	outcomes	outcome	NOUN
ijpds-3133	289	12	with	with	ADP
ijpds-3133	289	13	the	the	DET
ijpds-3133	289	14	help	help	NOUN
ijpds-3133	289	15	of	of	ADP
ijpds-3133	289	16	these	these	DET
ijpds-3133	289	17	devices	device	NOUN
ijpds-3133	289	18	is	be	AUX
ijpds-3133	289	19	unprecedented	unprecedented	ADJ
ijpds-3133	289	20	.	.	PUNCT
ijpds-3133	290	1	eye	eye	NOUN
ijpds-3133	290	2	drop	drop	NOUN
ijpds-3133	290	3	installation	installation	NOUN
ijpds-3133	290	4	has	have	AUX
ijpds-3133	290	5	always	always	ADV
ijpds-3133	290	6	been	be	AUX
ijpds-3133	290	7	a	a	DET
ijpds-3133	290	8	challenge	challenge	NOUN
ijpds-3133	290	9	,	,	PUNCT
ijpds-3133	290	10	especially	especially	ADV
ijpds-3133	290	11	in	in	ADP
ijpds-3133	290	12	the	the	DET
ijpds-3133	290	13	geriatric	geriatric	ADJ
ijpds-3133	290	14	and	and	CCONJ
ijpds-3133	290	15	pediatric	pediatric	ADJ
ijpds-3133	290	16	age	age	NOUN
ijpds-3133	290	17	group	group	NOUN
ijpds-3133	290	18	patients	patient	NOUN
ijpds-3133	290	19	.	.	PUNCT
ijpds-3133	291	1	effective	effective	ADJ
ijpds-3133	291	2	localized	localized	ADJ
ijpds-3133	291	3	delivery	delivery	NOUN
ijpds-3133	291	4	will	will	AUX
ijpds-3133	291	5	prevent	prevent	VERB
ijpds-3133	291	6	drug	drug	NOUN
ijpds-3133	291	7	loss	loss	NOUN
ijpds-3133	291	8	due	due	ADP
ijpds-3133	291	9	to	to	ADP
ijpds-3133	291	10	systemic	systemic	ADJ
ijpds-3133	291	11	absorption	absorption	NOUN
ijpds-3133	291	12	and	and	CCONJ
ijpds-3133	291	13	firstpass	firstpass	VERB
ijpds-3133	291	14	metabolism	metabolism	NOUN
ijpds-3133	291	15	thereby	thereby	ADV
ijpds-3133	291	16	,	,	PUNCT
ijpds-3133	291	17	minimizing	minimize	VERB
ijpds-3133	291	18	drug	drug	NOUN
ijpds-3133	291	19	wastage	wastage	NOUN
ijpds-3133	291	20	.	.	PUNCT
ijpds-3133	292	1	the	the	DET
ijpds-3133	292	2	prevalence	prevalence	NOUN
ijpds-3133	292	3	of	of	ADP
ijpds-3133	292	4	ocular	ocular	ADJ
ijpds-3133	292	5	surface	surface	NOUN
ijpds-3133	292	6	disease	disease	NOUN
ijpds-3133	292	7	in	in	ADP
ijpds-3133	292	8	patients	patient	NOUN
ijpds-3133	292	9	installing	instal	VERB
ijpds-3133	292	10	antiglaucoma	antiglaucoma	NOUN
ijpds-3133	292	11	drugs	drug	NOUN
ijpds-3133	292	12	with	with	ADP
ijpds-3133	292	13	added	add	VERB
ijpds-3133	292	14	preservatives	preservative	NOUN
ijpds-3133	292	15	may	may	AUX
ijpds-3133	292	16	be	be	AUX
ijpds-3133	292	17	overcome	overcome	VERB
ijpds-3133	292	18	with	with	ADP
ijpds-3133	292	19	the	the	DET
ijpds-3133	292	20	newer	new	ADJ
ijpds-3133	292	21	devices	device	NOUN
ijpds-3133	292	22	.	.	PUNCT
ijpds-3133	293	1	the	the	DET
ijpds-3133	293	2	most	most	ADV
ijpds-3133	293	3	significant	significant	ADJ
ijpds-3133	293	4	advantage	advantage	NOUN
ijpds-3133	293	5	of	of	ADP
ijpds-3133	293	6	these	these	DET
ijpds-3133	293	7	devices	device	NOUN
ijpds-3133	293	8	was	be	AUX
ijpds-3133	293	9	the	the	DET
ijpds-3133	293	10	improved	improved	ADJ
ijpds-3133	293	11	quality	quality	NOUN
ijpds-3133	293	12	of	of	ADP
ijpds-3133	293	13	life	life	NOUN
ijpds-3133	293	14	of	of	ADP
ijpds-3133	293	15	the	the	DET
ijpds-3133	293	16	patients	patient	NOUN
ijpds-3133	293	17	who	who	PRON
ijpds-3133	293	18	adhere	adhere	VERB
ijpds-3133	293	19	to	to	ADP
ijpds-3133	293	20	a	a	DET
ijpds-3133	293	21	strict	strict	ADJ
ijpds-3133	293	22	regime	regime	NOUN
ijpds-3133	293	23	of	of	ADP
ijpds-3133	293	24	repeatedly	repeatedly	ADV
ijpds-3133	293	25	putting	put	VERB
ijpds-3133	293	26	eye	eye	NOUN
ijpds-3133	293	27	drops	drop	NOUN
ijpds-3133	293	28	throughout	throughout	ADP
ijpds-3133	293	29	the	the	DET
ijpds-3133	293	30	day	day	NOUN
ijpds-3133	293	31	.	.	PUNCT
ijpds-3133	294	1	references	reference	NOUN
ijpds-3133	294	2	1	1	NUM
ijpds-3133	294	3	.	.	PUNCT
ijpds-3133	295	1	kingman	kingman	PROPN
ijpds-3133	295	2	s.	s.	PROPN
ijpds-3133	295	3	glaucoma	glaucoma	PROPN
ijpds-3133	295	4	is	be	AUX
ijpds-3133	295	5	second	second	ADJ
ijpds-3133	295	6	leading	leading	ADJ
ijpds-3133	295	7	cause	cause	NOUN
ijpds-3133	295	8	of	of	ADP
ijpds-3133	295	9	blindness	blindness	NOUN
ijpds-3133	295	10	globally	globally	ADV
ijpds-3133	295	11	.	.	PUNCT
ijpds-3133	296	1	bull	bull	PROPN
ijpds-3133	296	2	world	world	PROPN
ijpds-3133	296	3	health	health	NOUN
ijpds-3133	296	4	organ	organ	NOUN
ijpds-3133	296	5	.	.	PUNCT
ijpds-3133	297	1	2004	2004	NUM
ijpds-3133	297	2	;	;	PUNCT
ijpds-3133	297	3	82:887	82:887	NUM
ijpds-3133	297	4	-	-	SYM
ijpds-3133	297	5	88	88	NUM
ijpds-3133	297	6	.	.	PUNCT
ijpds-3133	298	1	2	2	X
ijpds-3133	298	2	.	.	X
ijpds-3133	298	3	quigley	quigley	PROPN
ijpds-3133	298	4	ha	ha	PROPN
ijpds-3133	298	5	,	,	PUNCT
ijpds-3133	298	6	broman	broman	NOUN
ijpds-3133	298	7	at	at	ADP
ijpds-3133	298	8	.	.	PUNCT
ijpds-3133	299	1	the	the	DET
ijpds-3133	299	2	number	number	NOUN
ijpds-3133	299	3	of	of	ADP
ijpds-3133	299	4	people	people	NOUN
ijpds-3133	299	5	with	with	ADP
ijpds-3133	299	6	glaucoma	glaucoma	NOUN
ijpds-3133	299	7	worldwide	worldwide	ADV
ijpds-3133	299	8	in	in	ADP
ijpds-3133	299	9	2010	2010	NUM
ijpds-3133	299	10	and	and	CCONJ
ijpds-3133	299	11	2020	2020	NUM
ijpds-3133	299	12	.	.	PUNCT
ijpds-3133	300	1	br	br	PROPN
ijpds-3133	300	2	j	j	PROPN
ijpds-3133	300	3	ophthalmol	ophthalmol	PROPN
ijpds-3133	300	4	.	.	PUNCT
ijpds-3133	301	1	2006	2006	NUM
ijpds-3133	301	2	;	;	PUNCT
ijpds-3133	301	3	90:262	90:262	NUM
ijpds-3133	301	4	-	-	SYM
ijpds-3133	301	5	67	67	NUM
ijpds-3133	301	6	.	.	PUNCT
ijpds-3133	302	1	3	3	NUM
ijpds-3133	302	2	.	.	X
ijpds-3133	302	3	hattenhauer	hattenhauer	PROPN
ijpds-3133	302	4	mg	mg	PROPN
ijpds-3133	302	5	,	,	PUNCT
ijpds-3133	302	6	johnson	johnson	PROPN
ijpds-3133	302	7	dh	dh	PROPN
ijpds-3133	302	8	,	,	PUNCT
ijpds-3133	302	9	ing	ing	NOUN
ijpds-3133	302	10	hh	hh	PROPN
ijpds-3133	302	11	,	,	PUNCT
ijpds-3133	302	12	et	et	PROPN
ijpds-3133	302	13	al	al	PROPN
ijpds-3133	302	14	.	.	PUNCT
ijpds-3133	303	1	the	the	DET
ijpds-3133	303	2	probability	probability	NOUN
ijpds-3133	303	3	of	of	ADP
ijpds-3133	303	4	blindness	blindness	NOUN
ijpds-3133	303	5	from	from	ADP
ijpds-3133	303	6	open	open	ADJ
ijpds-3133	303	7	-	-	PUNCT
ijpds-3133	303	8	angle	angle	NOUN
ijpds-3133	303	9	glaucoma	glaucoma	NOUN
ijpds-3133	303	10	.	.	PUNCT
ijpds-3133	304	1	ophthalmology	ophthalmology	NOUN
ijpds-3133	304	2	.	.	PUNCT
ijpds-3133	305	1	2001	2001	NUM
ijpds-3133	305	2	;	;	PUNCT
ijpds-3133	305	3	105:2099	105:2099	NUM
ijpds-3133	305	4	-	-	SYM
ijpds-3133	305	5	104	104	NUM
ijpds-3133	305	6	.	.	PUNCT
ijpds-3133	306	1	4	4	NUM
ijpds-3133	306	2	.	.	NUM
ijpds-3133	306	3	mohindroo	mohindroo	PROPN
ijpds-3133	306	4	c	c	PROPN
ijpds-3133	306	5	,	,	PUNCT
ijpds-3133	306	6	ichhpujani	ichhpujani	PROPN
ijpds-3133	306	7	p	p	X
ijpds-3133	306	8	,	,	PUNCT
ijpds-3133	306	9	kumar	kumar	PROPN
ijpds-3133	306	10	s.	s.	PROPN
ijpds-3133	306	11	how	how	SCONJ
ijpds-3133	306	12	‘	'	PUNCT
ijpds-3133	306	13	drug	drug	NOUN
ijpds-3133	306	14	aware	aware	ADJ
ijpds-3133	306	15	’	'	PUNCT
ijpds-3133	306	16	are	be	AUX
ijpds-3133	306	17	our	our	PRON
ijpds-3133	306	18	glaucoma	glaucoma	NOUN
ijpds-3133	306	19	patients	patient	NOUN
ijpds-3133	306	20	.	.	PUNCT
ijpds-3133	307	1	j	j	PROPN
ijpds-3133	307	2	curr	curr	PROPN
ijpds-3133	307	3	glaucoma	glaucoma	PROPN
ijpds-3133	307	4	pract	pract	PROPN
ijpds-3133	307	5	.	.	PUNCT
ijpds-3133	308	1	2015	2015	NUM
ijpds-3133	308	2	;	;	PUNCT
ijpds-3133	308	3	9:33	9:33	NUM
ijpds-3133	308	4	-	-	SYM
ijpds-3133	308	5	37	37	NUM
ijpds-3133	308	6	.	.	PUNCT
ijpds-3133	309	1	5	5	NUM
ijpds-3133	309	2	.	.	X
ijpds-3133	309	3	wilson	wilson	PROPN
ijpds-3133	309	4	cg	cg	PROPN
ijpds-3133	309	5	,	,	PUNCT
ijpds-3133	309	6	zhu	zhu	PROPN
ijpds-3133	309	7	yp	yp	PROPN
ijpds-3133	309	8	,	,	PUNCT
ijpds-3133	309	9	frier	frier	NOUN
ijpds-3133	309	10	m	m	PROPN
ijpds-3133	309	11	,	,	PUNCT
ijpds-3133	309	12	et	et	PROPN
ijpds-3133	309	13	al	al	PROPN
ijpds-3133	309	14	.	.	PROPN
ijpds-3133	310	1	ocular	ocular	ADJ
ijpds-3133	310	2	contact	contact	NOUN
ijpds-3133	310	3	time	time	NOUN
ijpds-3133	310	4	of	of	ADP
ijpds-3133	310	5	a	a	DET
ijpds-3133	310	6	carbomer	carbomer	NOUN
ijpds-3133	310	7	gel	gel	NOUN
ijpds-3133	310	8	(	(	PUNCT
ijpds-3133	310	9	geltears	geltear	NOUN
ijpds-3133	310	10	)	)	PUNCT
ijpds-3133	310	11	in	in	ADP
ijpds-3133	310	12	humans	human	NOUN
ijpds-3133	310	13	.	.	PUNCT
ijpds-3133	311	1	br	br	PROPN
ijpds-3133	312	1	j	j	PROPN
ijpds-3133	312	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	312	3	.	.	PUNCT
ijpds-3133	313	1	2000	2000	NUM
ijpds-3133	313	2	;	;	PUNCT
ijpds-3133	313	3	82:1131	82:1131	PROPN
ijpds-3133	313	4	-	-	SYM
ijpds-3133	313	5	34	34	NUM
ijpds-3133	313	6	.	.	NOUN
ijpds-3133	314	1	6	6	NUM
ijpds-3133	314	2	.	.	PUNCT
ijpds-3133	314	3	lee	lee	PROPN
ijpds-3133	314	4	vh	vh	PROPN
ijpds-3133	314	5	,	,	PUNCT
ijpds-3133	314	6	robinson	robinson	PROPN
ijpds-3133	314	7	jr	jr	PROPN
ijpds-3133	314	8	.	.	PROPN
ijpds-3133	314	9	topical	topical	ADJ
ijpds-3133	314	10	ocular	ocular	ADJ
ijpds-3133	314	11	drug	drug	NOUN
ijpds-3133	314	12	delivery	delivery	NOUN
ijpds-3133	314	13	:	:	PUNCT
ijpds-3133	314	14	recent	recent	ADJ
ijpds-3133	314	15	developments	development	NOUN
ijpds-3133	314	16	and	and	CCONJ
ijpds-3133	314	17	future	future	ADJ
ijpds-3133	314	18	challenges	challenge	NOUN
ijpds-3133	314	19	.	.	PUNCT
ijpds-3133	315	1	j	j	PROPN
ijpds-3133	315	2	ocul	ocul	PROPN
ijpds-3133	315	3	pharmacol	pharmacol	PROPN
ijpds-3133	315	4	.	.	PUNCT
ijpds-3133	316	1	2001	2001	NUM
ijpds-3133	316	2	;	;	PUNCT
ijpds-3133	316	3	2:67	2:67	NUM
ijpds-3133	316	4	-	-	SYM
ijpds-3133	316	5	108	108	NUM
ijpds-3133	316	6	.	.	PUNCT
ijpds-3133	317	1	7	7	X
ijpds-3133	317	2	.	.	PUNCT
ijpds-3133	317	3	wei	wei	PROPN
ijpds-3133	317	4	g	g	PROPN
ijpds-3133	317	5	,	,	PUNCT
ijpds-3133	317	6	xu	xu	PROPN
ijpds-3133	317	7	h	h	NOUN
ijpds-3133	317	8	,	,	PUNCT
ijpds-3133	317	9	ding	ding	NOUN
ijpds-3133	317	10	pt	pt	PROPN
ijpds-3133	317	11	,	,	PUNCT
ijpds-3133	317	12	et	et	PROPN
ijpds-3133	317	13	al	al	PROPN
ijpds-3133	317	14	.	.	PUNCT
ijpds-3133	317	15	thermosetting	thermosette	VERB
ijpds-3133	317	16	gels	gel	NOUN
ijpds-3133	317	17	with	with	ADP
ijpds-3133	317	18	modulated	modulate	VERB
ijpds-3133	317	19	gelation	gelation	NOUN
ijpds-3133	317	20	temperature	temperature	NOUN
ijpds-3133	317	21	for	for	ADP
ijpds-3133	317	22	ophthalmic	ophthalmic	ADJ
ijpds-3133	317	23	use	use	NOUN
ijpds-3133	317	24	:	:	PUNCT
ijpds-3133	317	25	the	the	DET
ijpds-3133	317	26	rheological	rheological	ADJ
ijpds-3133	317	27	and	and	CCONJ
ijpds-3133	317	28	gamma	gamma	NOUN
ijpds-3133	317	29	scintigraphic	scintigraphic	PROPN
ijpds-3133	317	30	studies	study	NOUN
ijpds-3133	317	31	.	.	PUNCT
ijpds-3133	318	1	j	j	PROPN
ijpds-3133	318	2	control	control	PROPN
ijpds-3133	318	3	release	release	PROPN
ijpds-3133	318	4	.	.	PUNCT
ijpds-3133	319	1	2002	2002	NUM
ijpds-3133	319	2	;	;	PUNCT
ijpds-3133	319	3	83:65	83:65	NUM
ijpds-3133	319	4	-	-	SYM
ijpds-3133	319	5	74	74	NUM
ijpds-3133	319	6	.	.	NOUN
ijpds-3133	320	1	8	8	NUM
ijpds-3133	320	2	.	.	X
ijpds-3133	320	3	walt	walt	PROPN
ijpds-3133	320	4	jg	jg	PROPN
ijpds-3133	320	5	,	,	PUNCT
ijpds-3133	320	6	wilensky	wilensky	PROPN
ijpds-3133	320	7	jt	jt	PROPN
ijpds-3133	320	8	,	,	PUNCT
ijpds-3133	320	9	fiscella	fiscella	PROPN
ijpds-3133	320	10	r	r	PROPN
ijpds-3133	320	11	,	,	PUNCT
ijpds-3133	320	12	et	et	PROPN
ijpds-3133	320	13	al	al	PROPN
ijpds-3133	320	14	.	.	PROPN
ijpds-3133	320	15	refill	refill	NOUN
ijpds-3133	320	16	rates	rate	NOUN
ijpds-3133	320	17	and	and	CCONJ
ijpds-3133	320	18	budget	budget	NOUN
ijpds-3133	320	19	impact	impact	NOUN
ijpds-3133	320	20	of	of	ADP
ijpds-3133	320	21	glaucoma	glaucoma	NOUN
ijpds-3133	320	22	lipid	lipid	NOUN
ijpds-3133	320	23	therapy	therapy	NOUN
ijpds-3133	320	24	:	:	PUNCT
ijpds-3133	320	25	a	a	DET
ijpds-3133	320	26	retrospective	retrospective	ADJ
ijpds-3133	320	27	database	database	NOUN
ijpds-3133	320	28	analysis	analysis	NOUN
ijpds-3133	320	29	.	.	PUNCT
ijpds-3133	321	1	clin	clin	PROPN
ijpds-3133	321	2	drug	drug	PROPN
ijpds-3133	321	3	investig	investig	PROPN
ijpds-3133	321	4	.	.	PROPN
ijpds-3133	321	5	2007	2007	NUM
ijpds-3133	321	6	;	;	PUNCT
ijpds-3133	321	7	27(12):819	27(12):819	NUM
ijpds-3133	321	8	-	-	SYM
ijpds-3133	321	9	25	25	NUM
ijpds-3133	321	10	.	.	NOUN
ijpds-3133	322	1	9	9	NUM
ijpds-3133	322	2	.	.	X
ijpds-3133	323	1	kumari	kumari	PROPN
ijpds-3133	323	2	a	a	PROPN
ijpds-3133	323	3	,	,	PUNCT
ijpds-3133	323	4	sharma	sharma	PROPN
ijpds-3133	323	5	pk	pk	PROPN
ijpds-3133	323	6	,	,	PUNCT
ijpds-3133	323	7	garg	garg	NOUN
ijpds-3133	323	8	vk	vk	PROPN
ijpds-3133	323	9	,	,	PUNCT
ijpds-3133	323	10	et	et	PROPN
ijpds-3133	323	11	al	al	PROPN
ijpds-3133	323	12	.	.	PROPN
ijpds-3133	323	13	ocular	ocular	ADJ
ijpds-3133	323	14	insertsadvancement	insertsadvancement	NOUN
ijpds-3133	323	15	in	in	ADP
ijpds-3133	323	16	therapy	therapy	NOUN
ijpds-3133	323	17	of	of	ADP
ijpds-3133	323	18	eye	eye	NOUN
ijpds-3133	323	19	diseases	disease	NOUN
ijpds-3133	323	20	.	.	PUNCT
ijpds-3133	324	1	j	j	PROPN
ijpds-3133	324	2	adv	adv	PROPN
ijpds-3133	324	3	pharm	pharm	PROPN
ijpds-3133	324	4	technol	technol	PROPN
ijpds-3133	324	5	res	re	NOUN
ijpds-3133	324	6	.	.	PUNCT
ijpds-3133	324	7	2010	2010	NUM
ijpds-3133	324	8	;	;	PUNCT
ijpds-3133	324	9	1:291	1:291	NUM
ijpds-3133	324	10	-	-	SYM
ijpds-3133	324	11	96	96	NUM
ijpds-3133	324	12	.	.	PUNCT
ijpds-3133	325	1	10	10	NUM
ijpds-3133	325	2	.	.	PUNCT
ijpds-3133	326	1	bensinger	bensinger	NOUN
ijpds-3133	326	2	r	r	PROPN
ijpds-3133	326	3	,	,	PUNCT
ijpds-3133	326	4	shin	shin	NOUN
ijpds-3133	326	5	dh	dh	PROPN
ijpds-3133	326	6	,	,	PUNCT
ijpds-3133	326	7	kass	kass	PROPN
ijpds-3133	326	8	ma	ma	PROPN
ijpds-3133	326	9	,	,	PUNCT
ijpds-3133	326	10	et	et	PROPN
ijpds-3133	326	11	al	al	PROPN
ijpds-3133	326	12	.	.	PROPN
ijpds-3133	326	13	pilocarpine	pilocarpine	PROPN
ijpds-3133	326	14	ocular	ocular	ADJ
ijpds-3133	326	15	inserts	insert	NOUN
ijpds-3133	326	16	.	.	PUNCT
ijpds-3133	327	1	invest	invest	VERB
ijpds-3133	327	2	ophthalmol	ophthalmol	NOUN
ijpds-3133	327	3	.	.	PUNCT
ijpds-3133	328	1	1976	1976	NUM
ijpds-3133	328	2	;	;	PUNCT
ijpds-3133	328	3	15:1008	15:1008	NUM
ijpds-3133	328	4	-	-	SYM
ijpds-3133	328	5	10	10	NUM
ijpds-3133	328	6	.	.	PUNCT
ijpds-3133	329	1	11	11	NUM
ijpds-3133	329	2	.	.	X
ijpds-3133	330	1	maichuk	maichuk	PROPN
ijpds-3133	330	2	yf	yf	PROPN
ijpds-3133	330	3	.	.	PUNCT
ijpds-3133	330	4	soluble	soluble	ADJ
ijpds-3133	330	5	ophthalmic	ophthalmic	ADJ
ijpds-3133	330	6	drug	drug	NOUN
ijpds-3133	330	7	inserts	insert	NOUN
ijpds-3133	330	8	.	.	PUNCT
ijpds-3133	331	1	lancet	lancet	PROPN
ijpds-3133	331	2	.	.	PUNCT
ijpds-3133	332	1	2013	2013	NUM
ijpds-3133	332	2	;	;	PUNCT
ijpds-3133	333	1	305:173	305:173	NUM
ijpds-3133	333	2	.	.	PUNCT
ijpds-3133	334	1	rai	rai	PROPN
ijpds-3133	334	2	et	et	PROPN
ijpds-3133	334	3	al	al	PROPN
ijpds-3133	334	4	mindful	mindful	ADJ
ijpds-3133	334	5	-	-	PUNCT
ijpds-3133	334	6	based	base	VERB
ijpds-3133	334	7	stress	stress	NOUN
ijpds-3133	334	8	reduction	reduction	NOUN
ijpds-3133	334	9	impact	impact	NOUN
ijpds-3133	334	10	vol	vol	NOUN
ijpds-3133	334	11	1	1	NUM
ijpds-3133	334	12	|	|	NOUN
ijpds-3133	334	13	issue	issue	NOUN
ijpds-3133	334	14	2	2	NUM
ijpds-3133	334	15	|	|	ADV
ijpds-3133	334	16	jul	jul	PROPN
ijpds-3133	334	17	–	–	PUNCT
ijpds-3133	334	18	sep	sep	PROPN
ijpds-3133	334	19	2022	2022	NUM
ijpds-3133	334	20	indian	indian	PROPN
ijpds-3133	334	21	j	j	PROPN
ijpds-3133	334	22	pharm	pharm	PROPN
ijpds-3133	334	23	drug	drug	PROPN
ijpds-3133	334	24	studies	study	NOUN
ijpds-3133	334	25	|	|	ADV
ijpds-3133	334	26	45	45	NUM
ijpds-3133	334	27	12	12	NUM
ijpds-3133	334	28	.	.	PUNCT
ijpds-3133	335	1	armaly	armaly	PROPN
ijpds-3133	335	2	mf	mf	PROPN
ijpds-3133	335	3	,	,	PUNCT
ijpds-3133	335	4	rao	rao	PROPN
ijpds-3133	335	5	kr	kr	PROPN
ijpds-3133	335	6	.	.	PUNCT
ijpds-3133	336	1	the	the	DET
ijpds-3133	336	2	effect	effect	NOUN
ijpds-3133	336	3	pf	pf	PROPN
ijpds-3133	336	4	pilocarpine	pilocarpine	NOUN
ijpds-3133	336	5	ocusert	ocusert	VERB
ijpds-3133	336	6	with	with	ADP
ijpds-3133	336	7	different	different	ADJ
ijpds-3133	336	8	release	release	NOUN
ijpds-3133	336	9	rates	rate	NOUN
ijpds-3133	336	10	on	on	ADP
ijpds-3133	336	11	ocular	ocular	ADJ
ijpds-3133	336	12	pressure	pressure	NOUN
ijpds-3133	336	13	.	.	PUNCT
ijpds-3133	337	1	invest	invest	VERB
ijpds-3133	337	2	ophthalmol	ophthalmol	NOUN
ijpds-3133	337	3	.	.	PUNCT
ijpds-3133	338	1	2003	2003	NUM
ijpds-3133	338	2	;	;	PUNCT
ijpds-3133	338	3	12:491	12:491	NUM
ijpds-3133	338	4	-	-	SYM
ijpds-3133	338	5	96	96	NUM
ijpds-3133	338	6	.	.	NOUN
ijpds-3133	339	1	13	13	NUM
ijpds-3133	339	2	.	.	PUNCT
ijpds-3133	340	1	worthen	worthen	PROPN
ijpds-3133	340	2	dm	dm	PROPN
ijpds-3133	340	3	,	,	PUNCT
ijpds-3133	340	4	zimmerman	zimmerman	PROPN
ijpds-3133	340	5	tj	tj	PROPN
ijpds-3133	340	6	,	,	PUNCT
ijpds-3133	340	7	wind	wind	NOUN
ijpds-3133	340	8	ca	ca	NOUN
ijpds-3133	340	9	.	.	PUNCT
ijpds-3133	341	1	an	an	DET
ijpds-3133	341	2	evaluation	evaluation	NOUN
ijpds-3133	341	3	of	of	ADP
ijpds-3133	341	4	the	the	DET
ijpds-3133	341	5	pilocarpine	pilocarpine	NOUN
ijpds-3133	341	6	ocusert	ocusert	PROPN
ijpds-3133	341	7	.	.	PUNCT
ijpds-3133	341	8	invest	invest	VERB
ijpds-3133	341	9	ophthalmol	ophthalmol	NOUN
ijpds-3133	341	10	.	.	PUNCT
ijpds-3133	342	1	2010	2010	NUM
ijpds-3133	342	2	;	;	PUNCT
ijpds-3133	343	1	13:29699	13:29699	X
ijpds-3133	343	2	.	.	X
ijpds-3133	344	1	14	14	NUM
ijpds-3133	344	2	.	.	X
ijpds-3133	344	3	macoul	macoul	PROPN
ijpds-3133	344	4	kl	kl	PROPN
ijpds-3133	344	5	,	,	PUNCT
ijpds-3133	344	6	pavan	pavan	PROPN
ijpds-3133	344	7	-	-	PUNCT
ijpds-3133	344	8	langton	langton	PROPN
ijpds-3133	344	9	d.	d.	PROPN
ijpds-3133	344	10	pilocarpine	pilocarpine	PROPN
ijpds-3133	344	11	ocusert	ocusert	PROPN
ijpds-3133	344	12	system	system	NOUN
ijpds-3133	344	13	for	for	ADP
ijpds-3133	344	14	sustained	sustained	ADJ
ijpds-3133	344	15	control	control	NOUN
ijpds-3133	344	16	of	of	ADP
ijpds-3133	344	17	ocular	ocular	ADJ
ijpds-3133	344	18	hypertension	hypertension	NOUN
ijpds-3133	344	19	.	.	PUNCT
ijpds-3133	345	1	arch	arch	PROPN
ijpds-3133	345	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	345	3	.	.	PUNCT
ijpds-3133	346	1	2010	2010	NUM
ijpds-3133	346	2	;	;	PUNCT
ijpds-3133	347	1	93:587	93:587	NUM
ijpds-3133	347	2	-	-	SYM
ijpds-3133	347	3	90	90	NUM
ijpds-3133	347	4	.	.	NOUN
ijpds-3133	347	5	15	15	NUM
ijpds-3133	347	6	.	.	PUNCT
ijpds-3133	348	1	sihvola	sihvola	NOUN
ijpds-3133	348	2	p	p	X
ijpds-3133	348	3	,	,	PUNCT
ijpds-3133	348	4	puustjarvi	puustjarvi	PROPN
ijpds-3133	348	5	t.	t.	NOUN
ijpds-3133	348	6	practical	practical	ADJ
ijpds-3133	348	7	problems	problem	NOUN
ijpds-3133	348	8	in	in	ADP
ijpds-3133	348	9	the	the	DET
ijpds-3133	348	10	use	use	NOUN
ijpds-3133	348	11	of	of	ADP
ijpds-3133	348	12	ocusertpilocarpine	ocusertpilocarpine	ADJ
ijpds-3133	348	13	delivery	delivery	NOUN
ijpds-3133	348	14	system	system	NOUN
ijpds-3133	348	15	.	.	PUNCT
ijpds-3133	349	1	acta	acta	PROPN
ijpds-3133	349	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	349	3	.	.	PUNCT
ijpds-3133	350	1	2002	2002	NUM
ijpds-3133	350	2	;	;	PUNCT
ijpds-3133	350	3	58:933	58:933	NUM
ijpds-3133	350	4	-	-	SYM
ijpds-3133	350	5	37	37	NUM
ijpds-3133	350	6	.	.	PUNCT
ijpds-3133	351	1	16	16	NUM
ijpds-3133	351	2	.	.	PUNCT
ijpds-3133	352	1	finne	finne	PROPN
ijpds-3133	352	2	u	u	NOUN
ijpds-3133	352	3	,	,	PUNCT
ijpds-3133	352	4	vaisanen	vaisanen	PROPN
ijpds-3133	352	5	v	v	NOUN
ijpds-3133	352	6	,	,	PUNCT
ijpds-3133	352	7	urtti	urtti	PROPN
ijpds-3133	352	8	a.	a.	NOUN
ijpds-3133	352	9	modification	modification	NOUN
ijpds-3133	352	10	of	of	ADP
ijpds-3133	352	11	ocular	ocular	ADJ
ijpds-3133	352	12	and	and	CCONJ
ijpds-3133	352	13	systemic	systemic	ADJ
ijpds-3133	352	14	absorption	absorption	NOUN
ijpds-3133	352	15	of	of	ADP
ijpds-3133	352	16	timolol	timolol	NOUN
ijpds-3133	352	17	from	from	ADP
ijpds-3133	352	18	ocular	ocular	ADJ
ijpds-3133	352	19	inserts	insert	NOUN
ijpds-3133	352	20	by	by	ADP
ijpds-3133	352	21	a	a	DET
ijpds-3133	352	22	buffering	buffering	NOUN
ijpds-3133	352	23	agent	agent	NOUN
ijpds-3133	352	24	and	and	CCONJ
ijpds-3133	352	25	a	a	DET
ijpds-3133	352	26	vasoconstrictor	vasoconstrictor	NOUN
ijpds-3133	352	27	.	.	PUNCT
ijpds-3133	353	1	int	int	PROPN
ijpds-3133	353	2	j	j	PROPN
ijpds-3133	353	3	pharm	pharm	PROPN
ijpds-3133	353	4	.	.	PUNCT
ijpds-3133	354	1	1990	1990	NUM
ijpds-3133	354	2	;	;	PUNCT
ijpds-3133	354	3	65:1927	65:1927	NUM
ijpds-3133	354	4	.	.	PROPN
ijpds-3133	354	5	17	17	NUM
ijpds-3133	354	6	.	.	PUNCT
ijpds-3133	355	1	tannebaum	tannebaum	PROPN
ijpds-3133	355	2	s	s	PROPN
ijpds-3133	355	3	,	,	PUNCT
ijpds-3133	355	4	svyatoslav	svyatoslav	PROPN
ijpds-3133	355	5	f.	f.	PROPN
ijpds-3133	355	6	innovative	innovative	PROPN
ijpds-3133	355	7	eye	eye	NOUN
ijpds-3133	355	8	surgeon	surgeon	NOUN
ijpds-3133	355	9	.	.	PUNCT
ijpds-3133	356	1	j	j	PROPN
ijpds-3133	356	2	am	be	AUX
ijpds-3133	356	3	optom	optom	PROPN
ijpds-3133	356	4	assoc	assoc	NOUN
ijpds-3133	356	5	.	.	PUNCT
ijpds-3133	357	1	2006	2006	NUM
ijpds-3133	357	2	;	;	PUNCT
ijpds-3133	357	3	66:652	66:652	NUM
ijpds-3133	357	4	-	-	SYM
ijpds-3133	357	5	54	54	NUM
ijpds-3133	357	6	.	.	PUNCT
ijpds-3133	358	1	18	18	NUM
ijpds-3133	358	2	.	.	PUNCT
ijpds-3133	359	1	bloomfield	bloomfield	PROPN
ijpds-3133	359	2	se	se	PROPN
ijpds-3133	359	3	,	,	PUNCT
ijpds-3133	359	4	miyata	miyata	PROPN
ijpds-3133	359	5	t	t	PROPN
ijpds-3133	359	6	,	,	PUNCT
ijpds-3133	359	7	dunn	dunn	PROPN
ijpds-3133	359	8	mw	mw	PROPN
ijpds-3133	359	9	,	,	PUNCT
ijpds-3133	359	10	et	et	PROPN
ijpds-3133	359	11	al	al	PROPN
ijpds-3133	359	12	.	.	PROPN
ijpds-3133	360	1	soluble	soluble	ADJ
ijpds-3133	360	2	gentamicin	gentamicin	VERB
ijpds-3133	360	3	ophthalmic	ophthalmic	ADJ
ijpds-3133	360	4	inserts	insert	NOUN
ijpds-3133	360	5	as	as	ADP
ijpds-3133	360	6	a	a	DET
ijpds-3133	360	7	drug	drug	NOUN
ijpds-3133	360	8	delivery	delivery	NOUN
ijpds-3133	360	9	system	system	NOUN
ijpds-3133	360	10	.	.	PUNCT
ijpds-3133	361	1	arch	arch	PROPN
ijpds-3133	361	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	361	3	.	.	PUNCT
ijpds-3133	362	1	1978	1978	NUM
ijpds-3133	362	2	;	;	PUNCT
ijpds-3133	362	3	96:885	96:885	NUM
ijpds-3133	362	4	-	-	SYM
ijpds-3133	362	5	87	87	NUM
ijpds-3133	362	6	.	.	PUNCT
ijpds-3133	363	1	19	19	NUM
ijpds-3133	363	2	.	.	PUNCT
ijpds-3133	364	1	agban	agban	NOUN
ijpds-3133	364	2	y	y	PROPN
ijpds-3133	364	3	,	,	PUNCT
ijpds-3133	364	4	lian	lian	PROPN
ijpds-3133	364	5	j	j	PROPN
ijpds-3133	364	6	,	,	PUNCT
ijpds-3133	364	7	prabakar	prabakar	NOUN
ijpds-3133	364	8	s	s	PROPN
ijpds-3133	364	9	,	,	PUNCT
ijpds-3133	364	10	et	et	PROPN
ijpds-3133	364	11	al	al	PROPN
ijpds-3133	364	12	.	.	PROPN
ijpds-3133	364	13	nanoparticle	nanoparticle	PROPN
ijpds-3133	364	14	cross	cross	PROPN
ijpds-3133	364	15	linked	link	VERB
ijpds-3133	364	16	collagen	collagen	NOUN
ijpds-3133	364	17	shields	shield	NOUN
ijpds-3133	364	18	for	for	ADP
ijpds-3133	364	19	sustained	sustained	ADJ
ijpds-3133	364	20	delivery	delivery	NOUN
ijpds-3133	364	21	of	of	ADP
ijpds-3133	364	22	pilocarpine	pilocarpine	NOUN
ijpds-3133	364	23	hydrochloride	hydrochloride	NOUN
ijpds-3133	364	24	.	.	PUNCT
ijpds-3133	365	1	int	int	NOUN
ijpds-3133	365	2	j	j	PROPN
ijpds-3133	365	3	pharm	pharm	PROPN
ijpds-3133	365	4	.	.	PUNCT
ijpds-3133	366	1	2016	2016	NUM
ijpds-3133	366	2	;	;	PUNCT
ijpds-3133	367	1	501:96	501:96	NUM
ijpds-3133	367	2	-	-	SYM
ijpds-3133	367	3	101	101	NUM
ijpds-3133	367	4	.	.	NOUN
ijpds-3133	367	5	20	20	NUM
ijpds-3133	367	6	.	.	PUNCT
ijpds-3133	368	1	katz	katz	PROPN
ijpds-3133	368	2	i	i	PRON
ijpds-3133	368	3	m	m	PROPN
ijpds-3133	368	4	,	,	PUNCT
ijpds-3133	368	5	blackman	blackman	PROPN
ijpds-3133	368	6	wm	wm	PROPN
ijpds-3133	368	7	.	.	PROPN
ijpds-3133	369	1	a	a	DET
ijpds-3133	369	2	soluble	soluble	ADJ
ijpds-3133	369	3	sustained	sustained	ADJ
ijpds-3133	369	4	release	release	NOUN
ijpds-3133	369	5	ophthalmic	ophthalmic	ADJ
ijpds-3133	369	6	delivery	delivery	NOUN
ijpds-3133	369	7	unit	unit	NOUN
ijpds-3133	369	8	.	.	PUNCT
ijpds-3133	370	1	am	be	AUX
ijpds-3133	370	2	j	j	PROPN
ijpds-3133	370	3	ophthalmol	ophthalmol	PROPN
ijpds-3133	370	4	.	.	PUNCT
ijpds-3133	371	1	2010	2010	NUM
ijpds-3133	371	2	;	;	PUNCT
ijpds-3133	371	3	83:728	83:728	NUM
ijpds-3133	371	4	-	-	SYM
ijpds-3133	371	5	34	34	NUM
ijpds-3133	371	6	.	.	PUNCT
ijpds-3133	372	1	21	21	NUM
ijpds-3133	372	2	.	.	PUNCT
ijpds-3133	373	1	bawa	bawa	PROPN
ijpds-3133	373	2	r	r	PROPN
ijpds-3133	373	3	,	,	PUNCT
ijpds-3133	373	4	nandu	nandu	NOUN
ijpds-3133	373	5	m.	m.	NOUN
ijpds-3133	373	6	physico	physico	NOUN
ijpds-3133	373	7	-	-	PUNCT
ijpds-3133	373	8	chemical	chemical	NOUN
ijpds-3133	373	9	considerations	consideration	NOUN
ijpds-3133	373	10	in	in	ADP
ijpds-3133	373	11	the	the	DET
ijpds-3133	373	12	development	development	NOUN
ijpds-3133	373	13	of	of	ADP
ijpds-3133	373	14	an	an	DET
ijpds-3133	373	15	ocular	ocular	ADJ
ijpds-3133	373	16	polymeric	polymeric	ADJ
ijpds-3133	373	17	drug	drug	NOUN
ijpds-3133	373	18	delivery	delivery	NOUN
ijpds-3133	373	19	system	system	NOUN
ijpds-3133	373	20	.	.	PUNCT
ijpds-3133	374	1	biomaterials	biomaterial	NOUN
ijpds-3133	374	2	.	.	PUNCT
ijpds-3133	375	1	2002	2002	NUM
ijpds-3133	375	2	;	;	PUNCT
ijpds-3133	375	3	11:724	11:724	NUM
ijpds-3133	375	4	-	-	SYM
ijpds-3133	375	5	28	28	NUM
ijpds-3133	375	6	.	.	PUNCT
ijpds-3133	376	1	22	22	NUM
ijpds-3133	376	2	.	.	PUNCT
ijpds-3133	377	1	diestelhorst	diestelhorst	PROPN
ijpds-3133	377	2	m	m	PROPN
ijpds-3133	377	3	,	,	PUNCT
ijpds-3133	377	4	krieglstein	krieglstein	PROPN
ijpds-3133	377	5	gk	gk	PROPN
ijpds-3133	377	6	.	.	PUNCT
ijpds-3133	378	1	the	the	DET
ijpds-3133	378	2	ocular	ocular	ADJ
ijpds-3133	378	3	tolerability	tolerability	NOUN
ijpds-3133	378	4	of	of	ADP
ijpds-3133	378	5	a	a	DET
ijpds-3133	378	6	new	new	ADJ
ijpds-3133	378	7	ophthalmic	ophthalmic	ADJ
ijpds-3133	378	8	drug	drug	NOUN
ijpds-3133	378	9	delivery	delivery	NOUN
ijpds-3133	378	10	system	system	NOUN
ijpds-3133	378	11	(	(	PUNCT
ijpds-3133	378	12	nods	nod	VERB
ijpds-3133	378	13	)	)	PUNCT
ijpds-3133	378	14	.	.	PUNCT
ijpds-3133	379	1	int	int	PROPN
ijpds-3133	379	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	379	3	.	.	PUNCT
ijpds-3133	379	4	1994	1994	NUM
ijpds-3133	379	5	;	;	PUNCT
ijpds-3133	379	6	18:1	18:1	NUM
ijpds-3133	379	7	-	-	SYM
ijpds-3133	379	8	4	4	NUM
ijpds-3133	379	9	.	.	NOUN
ijpds-3133	379	10	23	23	NUM
ijpds-3133	379	11	.	.	PUNCT
ijpds-3133	380	1	greaves	greave	VERB
ijpds-3133	380	2	j	j	PROPN
ijpds-3133	380	3	,	,	PUNCT
ijpds-3133	380	4	wilson	wilson	PROPN
ijpds-3133	380	5	c	c	PROPN
ijpds-3133	380	6	,	,	PUNCT
ijpds-3133	380	7	birmingham	birmingham	PROPN
ijpds-3133	380	8	a	a	X
ijpds-3133	380	9	,	,	PUNCT
ijpds-3133	380	10	et	et	PROPN
ijpds-3133	380	11	al	al	PROPN
ijpds-3133	380	12	.	.	PROPN
ijpds-3133	380	13	scintigraphic	scintigraphic	PROPN
ijpds-3133	380	14	studies	study	NOUN
ijpds-3133	380	15	on	on	ADP
ijpds-3133	380	16	the	the	DET
ijpds-3133	380	17	corneal	corneal	ADJ
ijpds-3133	380	18	residence	residence	NOUN
ijpds-3133	380	19	of	of	ADP
ijpds-3133	380	20	a	a	DET
ijpds-3133	380	21	new	new	ADJ
ijpds-3133	380	22	ophthalmic	ophthalmic	ADJ
ijpds-3133	380	23	delivery	delivery	NOUN
ijpds-3133	380	24	system	system	NOUN
ijpds-3133	380	25	(	(	PUNCT
ijpds-3133	380	26	nods	nod	VERB
ijpds-3133	380	27	):	):	PUNCT
ijpds-3133	380	28	rate	rate	NOUN
ijpds-3133	380	29	of	of	ADP
ijpds-3133	380	30	clearance	clearance	NOUN
ijpds-3133	380	31	of	of	ADP
ijpds-3133	380	32	a	a	DET
ijpds-3133	380	33	soluble	soluble	ADJ
ijpds-3133	380	34	marker	marker	NOUN
ijpds-3133	380	35	in	in	ADP
ijpds-3133	380	36	relation	relation	NOUN
ijpds-3133	380	37	to	to	ADP
ijpds-3133	380	38	duration	duration	NOUN
ijpds-3133	380	39	of	of	ADP
ijpds-3133	380	40	pharmacological	pharmacological	ADJ
ijpds-3133	380	41	action	action	NOUN
ijpds-3133	380	42	of	of	ADP
ijpds-3133	380	43	pilocarpine	pilocarpine	NOUN
ijpds-3133	380	44	.	.	PUNCT
ijpds-3133	381	1	br	br	PROPN
ijpds-3133	382	1	j	j	PROPN
ijpds-3133	382	2	clin	clin	PROPN
ijpds-3133	382	3	pharmacol	pharmacol	PROPN
ijpds-3133	382	4	.	.	PROPN
ijpds-3133	382	5	2000	2000	NUM
ijpds-3133	382	6	;	;	PUNCT
ijpds-3133	382	7	33:603	33:603	NUM
ijpds-3133	382	8	-	-	SYM
ijpds-3133	382	9	09	09	NUM
ijpds-3133	382	10	.	.	PUNCT
ijpds-3133	383	1	24	24	NUM
ijpds-3133	383	2	.	.	PUNCT
ijpds-3133	384	1	brandt	brandt	PROPN
ijpds-3133	384	2	jd	jd	PROPN
ijpds-3133	384	3	,	,	PUNCT
ijpds-3133	384	4	sall	sall	PROPN
ijpds-3133	384	5	k	k	PROPN
ijpds-3133	384	6	,	,	PUNCT
ijpds-3133	384	7	dubiner	dubiner	PROPN
ijpds-3133	384	8	h	h	PROPN
ijpds-3133	384	9	,	,	PUNCT
ijpds-3133	384	10	et	et	PROPN
ijpds-3133	384	11	al	al	PROPN
ijpds-3133	384	12	.	.	PROPN
ijpds-3133	384	13	six	six	NUM
ijpds-3133	384	14	months	month	NOUN
ijpds-3133	384	15	intraocular	intraocular	ADJ
ijpds-3133	384	16	pressure	pressure	NOUN
ijpds-3133	384	17	reduction	reduction	NOUN
ijpds-3133	384	18	with	with	ADP
ijpds-3133	384	19	a	a	DET
ijpds-3133	384	20	topical	topical	ADJ
ijpds-3133	384	21	bimatoprost	bimatoprost	NOUN
ijpds-3133	384	22	ocular	ocular	ADJ
ijpds-3133	384	23	insert	insert	NOUN
ijpds-3133	384	24	:	:	PUNCT
ijpds-3133	384	25	results	result	NOUN
ijpds-3133	384	26	of	of	ADP
ijpds-3133	384	27	a	a	DET
ijpds-3133	384	28	phase	phase	NOUN
ijpds-3133	384	29	ii	ii	NOUN
ijpds-3133	384	30	randomized	randomize	VERB
ijpds-3133	384	31	controlled	control	VERB
ijpds-3133	384	32	study	study	NOUN
ijpds-3133	384	33	.	.	PUNCT
ijpds-3133	385	1	ophthalmology	ophthalmology	NOUN
ijpds-3133	385	2	.	.	PUNCT
ijpds-3133	386	1	2016	2016	NUM
ijpds-3133	386	2	;	;	PUNCT
ijpds-3133	386	3	123:1685	123:1685	NUM
ijpds-3133	386	4	-	-	SYM
ijpds-3133	386	5	94	94	NUM
ijpds-3133	386	6	.	.	PUNCT
ijpds-3133	387	1	25	25	NUM
ijpds-3133	387	2	.	.	PUNCT
ijpds-3133	387	3	de	de	PROPN
ijpds-3133	387	4	souza	souza	PROPN
ijpds-3133	387	5	jf	jf	PROPN
ijpds-3133	387	6	,	,	PUNCT
ijpds-3133	387	7	maia	maia	PROPN
ijpds-3133	387	8	kn	kn	PROPN
ijpds-3133	387	9	,	,	PUNCT
ijpds-3133	387	10	de	de	PROPN
ijpds-3133	387	11	oliveria	oliveria	PROPN
ijpds-3133	387	12	patricio	patricio	PROPN
ijpds-3133	387	13	ps	ps	PROPN
ijpds-3133	387	14	,	,	PUNCT
ijpds-3133	387	15	et	et	PROPN
ijpds-3133	387	16	al	al	PROPN
ijpds-3133	387	17	.	.	PROPN
ijpds-3133	387	18	ocular	ocular	ADJ
ijpds-3133	387	19	inserts	insert	NOUN
ijpds-3133	387	20	based	base	VERB
ijpds-3133	387	21	on	on	ADP
ijpds-3133	387	22	chitosan	chitosan	NOUN
ijpds-3133	387	23	and	and	CCONJ
ijpds-3133	387	24	brimonidine	brimonidine	NOUN
ijpds-3133	387	25	tartrate	tartrate	NOUN
ijpds-3133	387	26	:	:	PUNCT
ijpds-3133	387	27	development	development	NOUN
ijpds-3133	387	28	,	,	PUNCT
ijpds-3133	387	29	characterization	characterization	NOUN
ijpds-3133	387	30	and	and	CCONJ
ijpds-3133	387	31	biocompatibility	biocompatibility	NOUN
ijpds-3133	387	32	.	.	PUNCT
ijpds-3133	388	1	j	j	PROPN
ijpds-3133	388	2	drug	drug	PROPN
ijpds-3133	388	3	deliv	deliv	VERB
ijpds-3133	388	4	sci	sci	PROPN
ijpds-3133	388	5	tech	tech	NOUN
ijpds-3133	388	6	.	.	PUNCT
ijpds-3133	389	1	2016	2016	NUM
ijpds-3133	389	2	;	;	PUNCT
ijpds-3133	389	3	32:21	32:21	NUM
ijpds-3133	389	4	-	-	SYM
ijpds-3133	389	5	30	30	NUM
ijpds-3133	389	6	.	.	PUNCT
ijpds-3133	390	1	26	26	NUM
ijpds-3133	390	2	.	.	PUNCT
ijpds-3133	391	1	stewart	stewart	PROPN
ijpds-3133	391	2	rh	rh	PROPN
ijpds-3133	391	3	,	,	PUNCT
ijpds-3133	391	4	novak	novak	PROPN
ijpds-3133	391	5	s.	s.	PROPN
ijpds-3133	391	6	introduction	introduction	NOUN
ijpds-3133	391	7	of	of	ADP
ijpds-3133	391	8	the	the	DET
ijpds-3133	391	9	ocusert	ocusert	ADJ
ijpds-3133	391	10	ocular	ocular	ADJ
ijpds-3133	391	11	system	system	NOUN
ijpds-3133	391	12	to	to	ADP
ijpds-3133	391	13	an	an	DET
ijpds-3133	391	14	ophthalmic	ophthalmic	ADJ
ijpds-3133	391	15	practice	practice	NOUN
ijpds-3133	391	16	.	.	PUNCT
ijpds-3133	391	17	am	be	AUX
ijpds-3133	391	18	ophthalmol	ophthalmol	ADJ
ijpds-3133	391	19	.	.	PUNCT
ijpds-3133	392	1	2000	2000	NUM
ijpds-3133	392	2	;	;	PUNCT
ijpds-3133	392	3	10:325	10:325	NUM
ijpds-3133	392	4	-	-	SYM
ijpds-3133	392	5	30	30	NUM
ijpds-3133	392	6	.	.	PUNCT
ijpds-3133	393	1	27	27	NUM
ijpds-3133	393	2	.	.	PUNCT
ijpds-3133	394	1	hitoshi	hitoshi	PROPN
ijpds-3133	394	2	s	s	PROPN
ijpds-3133	394	3	,	,	PUNCT
ijpds-3133	394	4	choyu	choyu	PROPN
ijpds-3133	394	5	t	t	PROPN
ijpds-3133	394	6	,	,	PUNCT
ijpds-3133	394	7	koyo	koyo	PROPN
ijpds-3133	394	8	n	n	CCONJ
ijpds-3133	394	9	,	,	PUNCT
ijpds-3133	394	10	et	et	PROPN
ijpds-3133	394	11	al	al	PROPN
ijpds-3133	394	12	.	.	PROPN
ijpds-3133	394	13	drug	drug	NOUN
ijpds-3133	394	14	release	release	NOUN
ijpds-3133	394	15	from	from	ADP
ijpds-3133	394	16	an	an	DET
ijpds-3133	394	17	ophthalmic	ophthalmic	ADJ
ijpds-3133	394	18	insert	insert	NOUN
ijpds-3133	394	19	of	of	ADP
ijpds-3133	394	20	a	a	DET
ijpds-3133	394	21	beta	beta	NOUN
ijpds-3133	394	22	-	-	PUNCT
ijpds-3133	394	23	blocker	blocker	NOUN
ijpds-3133	394	24	as	as	ADP
ijpds-3133	394	25	an	an	DET
ijpds-3133	394	26	ocular	ocular	ADJ
ijpds-3133	394	27	drug	drug	NOUN
ijpds-3133	394	28	delivery	delivery	NOUN
ijpds-3133	394	29	system	system	NOUN
ijpds-3133	394	30	.	.	PUNCT
ijpds-3133	395	1	j	j	PROPN
ijpds-3133	395	2	control	control	PROPN
ijpds-3133	395	3	release	release	PROPN
ijpds-3133	395	4	.	.	PUNCT
ijpds-3133	396	1	2001	2001	NUM
ijpds-3133	396	2	;	;	PUNCT
ijpds-3133	396	3	27:127	27:127	NUM
ijpds-3133	396	4	-	-	SYM
ijpds-3133	396	5	37	37	NUM
ijpds-3133	396	6	.	.	PUNCT
ijpds-3133	397	1	28	28	NUM
ijpds-3133	397	2	.	.	PUNCT
ijpds-3133	398	1	li	li	PROPN
ijpds-3133	398	2	cc	cc	PROPN
ijpds-3133	398	3	,	,	PUNCT
ijpds-3133	398	4	chauhan	chauhan	PROPN
ijpds-3133	398	5	a.	a.	NOUN
ijpds-3133	398	6	modeling	model	VERB
ijpds-3133	398	7	ophthalmic	ophthalmic	ADJ
ijpds-3133	398	8	drug	drug	NOUN
ijpds-3133	398	9	delivery	delivery	NOUN
ijpds-3133	398	10	by	by	ADP
ijpds-3133	398	11	soaked	soaked	ADJ
ijpds-3133	398	12	contact	contact	NOUN
ijpds-3133	398	13	lenses	lense	NOUN
ijpds-3133	398	14	.	.	PUNCT
ijpds-3133	399	1	ind	ind	PROPN
ijpds-3133	399	2	eng	eng	PROPN
ijpds-3133	399	3	chem	chem	NOUN
ijpds-3133	399	4	res	re	NOUN
ijpds-3133	399	5	.	.	PUNCT
ijpds-3133	400	1	2006	2006	NUM
ijpds-3133	400	2	;	;	PUNCT
ijpds-3133	400	3	45:3718	45:3718	NUM
ijpds-3133	400	4	-	-	SYM
ijpds-3133	400	5	34	34	NUM
ijpds-3133	400	6	.	.	NOUN
ijpds-3133	400	7	29	29	NUM
ijpds-3133	400	8	.	.	PUNCT
ijpds-3133	401	1	peng	peng	PROPN
ijpds-3133	401	2	cc	cc	PROPN
ijpds-3133	401	3	,	,	PUNCT
ijpds-3133	401	4	kim	kim	PROPN
ijpds-3133	401	5	j	j	PROPN
ijpds-3133	401	6	,	,	PUNCT
ijpds-3133	401	7	chauhan	chauhan	PROPN
ijpds-3133	401	8	a.	a.	PROPN
ijpds-3133	401	9	extended	extend	VERB
ijpds-3133	401	10	delivery	delivery	NOUN
ijpds-3133	401	11	of	of	ADP
ijpds-3133	401	12	hydrophilic	hydrophilic	ADJ
ijpds-3133	401	13	drugs	drug	NOUN
ijpds-3133	401	14	from	from	ADP
ijpds-3133	401	15	siliconehydrogel	siliconehydrogel	NOUN
ijpds-3133	401	16	contact	contact	NOUN
ijpds-3133	401	17	lenses	lense	NOUN
ijpds-3133	401	18	containing	contain	VERB
ijpds-3133	401	19	vitamin	vitamin	NOUN
ijpds-3133	401	20	e	e	NOUN
ijpds-3133	401	21	diffusion	diffusion	NOUN
ijpds-3133	401	22	barriers	barrier	NOUN
ijpds-3133	401	23	.	.	PUNCT
ijpds-3133	402	1	biomaterials	biomaterial	NOUN
ijpds-3133	402	2	.	.	PUNCT
ijpds-3133	403	1	2010	2010	NUM
ijpds-3133	403	2	;	;	PUNCT
ijpds-3133	403	3	31:4032	31:4032	NOUN
ijpds-3133	403	4	-	-	PROPN
ijpds-3133	403	5	47	47	NUM
ijpds-3133	403	6	.	.	PUNCT
ijpds-3133	404	1	30	30	NUM
ijpds-3133	404	2	.	.	PUNCT
ijpds-3133	405	1	peppas	peppas	PROPN
ijpds-3133	405	2	na	na	NOUN
ijpds-3133	405	3	,	,	PUNCT
ijpds-3133	405	4	bures	bure	NOUN
ijpds-3133	405	5	p	p	NOUN
ijpds-3133	405	6	,	,	PUNCT
ijpds-3133	405	7	leobandung	leobandung	PROPN
ijpds-3133	405	8	w	w	PROPN
ijpds-3133	405	9	,	,	PUNCT
ijpds-3133	405	10	et	et	PROPN
ijpds-3133	405	11	al	al	PROPN
ijpds-3133	405	12	.	.	PROPN
ijpds-3133	405	13	hydrogels	hydrogel	NOUN
ijpds-3133	405	14	in	in	ADP
ijpds-3133	405	15	pharmaceutical	pharmaceutical	ADJ
ijpds-3133	405	16	formulations	formulation	NOUN
ijpds-3133	405	17	.	.	PUNCT
ijpds-3133	406	1	eur	eur	PROPN
ijpds-3133	406	2	j	j	PROPN
ijpds-3133	406	3	pharm	pharm	PROPN
ijpds-3133	406	4	biopharm	biopharm	PROPN
ijpds-3133	406	5	.	.	PUNCT
ijpds-3133	407	1	2000	2000	NUM
ijpds-3133	407	2	;	;	PUNCT
ijpds-3133	407	3	50:27	50:27	NUM
ijpds-3133	407	4	-	-	SYM
ijpds-3133	407	5	46	46	NUM
ijpds-3133	407	6	.	.	PUNCT
ijpds-3133	408	1	31	31	NUM
ijpds-3133	408	2	.	.	PUNCT
ijpds-3133	409	1	hiratani	hiratani	PROPN
ijpds-3133	409	2	h	h	PROPN
ijpds-3133	409	3	,	,	PUNCT
ijpds-3133	409	4	alvarez	alvarez	PROPN
ijpds-3133	409	5	-	-	PUNCT
ijpds-3133	409	6	lorenzo	lorenzo	PROPN
ijpds-3133	409	7	c.	c.	PROPN
ijpds-3133	409	8	timolol	timolol	VERB
ijpds-3133	409	9	uptake	uptake	NOUN
ijpds-3133	409	10	and	and	CCONJ
ijpds-3133	409	11	release	release	VERB
ijpds-3133	409	12	by	by	ADP
ijpds-3133	409	13	imprinted	imprint	VERB
ijpds-3133	409	14	soft	soft	ADJ
ijpds-3133	409	15	contact	contact	NOUN
ijpds-3133	409	16	lenses	lense	NOUN
ijpds-3133	409	17	made	make	VERB
ijpds-3133	409	18	of	of	ADP
ijpds-3133	409	19	n	n	CCONJ
ijpds-3133	409	20	,	,	PUNCT
ijpds-3133	409	21	ndiethylacrylamide	ndiethylacrylamide	NOUN
ijpds-3133	409	22	and	and	CCONJ
ijpds-3133	409	23	methylacrylic	methylacrylic	ADJ
ijpds-3133	409	24	acid	acid	PROPN
ijpds-3133	409	25	.	.	PUNCT
ijpds-3133	410	1	j	j	PROPN
ijpds-3133	410	2	control	control	PROPN
ijpds-3133	410	3	release	release	PROPN
ijpds-3133	410	4	.	.	PUNCT
ijpds-3133	411	1	2002	2002	NUM
ijpds-3133	411	2	;	;	PUNCT
ijpds-3133	411	3	83:223	83:223	NUM
ijpds-3133	411	4	-	-	SYM
ijpds-3133	411	5	30	30	NUM
ijpds-3133	411	6	.	.	PUNCT
ijpds-3133	412	1	32	32	NUM
ijpds-3133	412	2	.	.	PUNCT
ijpds-3133	413	1	waltman	waltman	PROPN
ijpds-3133	413	2	sr	sr	PROPN
ijpds-3133	413	3	,	,	PUNCT
ijpds-3133	413	4	kaufman	kaufman	PROPN
ijpds-3133	413	5	he	he	PRON
ijpds-3133	413	6	.	.	PUNCT
ijpds-3133	414	1	use	use	NOUN
ijpds-3133	414	2	of	of	ADP
ijpds-3133	414	3	hydrophilic	hydrophilic	ADJ
ijpds-3133	414	4	contact	contact	NOUN
ijpds-3133	414	5	lenses	lense	NOUN
ijpds-3133	414	6	to	to	PART
ijpds-3133	414	7	increase	increase	VERB
ijpds-3133	414	8	ocular	ocular	ADJ
ijpds-3133	414	9	penetration	penetration	NOUN
ijpds-3133	414	10	of	of	ADP
ijpds-3133	414	11	topical	topical	ADJ
ijpds-3133	414	12	drugs	drug	NOUN
ijpds-3133	414	13	.	.	PUNCT
ijpds-3133	415	1	invest	invest	VERB
ijpds-3133	415	2	ophthalmol	ophthalmol	NOUN
ijpds-3133	415	3	.	.	PUNCT
ijpds-3133	415	4	2008	2008	NUM
ijpds-3133	415	5	;	;	PUNCT
ijpds-3133	415	6	9:250	9:250	NUM
ijpds-3133	415	7	-	-	SYM
ijpds-3133	415	8	55	55	NUM
ijpds-3133	415	9	.	.	PUNCT
ijpds-3133	416	1	33	33	NUM
ijpds-3133	416	2	.	.	PUNCT
ijpds-3133	417	1	hillman	hillman	PROPN
ijpds-3133	417	2	js	js	PROPN
ijpds-3133	417	3	.	.	PUNCT
ijpds-3133	418	1	management	management	NOUN
ijpds-3133	418	2	of	of	ADP
ijpds-3133	418	3	acute	acute	ADJ
ijpds-3133	418	4	glaucoma	glaucoma	NOUN
ijpds-3133	418	5	with	with	ADP
ijpds-3133	418	6	pilocarpine	pilocarpine	NOUN
ijpds-3133	418	7	soaked	soak	VERB
ijpds-3133	418	8	hydrophilic	hydrophilic	ADJ
ijpds-3133	418	9	lens	len	NOUN
ijpds-3133	418	10	.	.	PUNCT
ijpds-3133	419	1	br	br	PROPN
ijpds-3133	420	1	j	j	PROPN
ijpds-3133	420	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	420	3	.	.	PUNCT
ijpds-3133	421	1	2009	2009	NUM
ijpds-3133	421	2	;	;	PUNCT
ijpds-3133	421	3	58:674	58:674	NUM
ijpds-3133	421	4	-	-	SYM
ijpds-3133	421	5	79	79	NUM
ijpds-3133	421	6	.	.	PUNCT
ijpds-3133	422	1	34	34	NUM
ijpds-3133	422	2	.	.	PUNCT
ijpds-3133	422	3	gulsen	gulsen	PROPN
ijpds-3133	423	1	d	d	PROPN
ijpds-3133	423	2	,	,	PUNCT
ijpds-3133	423	3	chauhan	chauhan	PROPN
ijpds-3133	423	4	a.	a.	NOUN
ijpds-3133	423	5	dispersion	dispersion	NOUN
ijpds-3133	423	6	of	of	ADP
ijpds-3133	423	7	micro	micro	ADJ
ijpds-3133	423	8	emulsion	emulsion	NOUN
ijpds-3133	423	9	drops	drop	VERB
ijpds-3133	423	10	in	in	ADP
ijpds-3133	423	11	hema	hema	PROPN
ijpds-3133	423	12	hydrogel	hydrogel	PROPN
ijpds-3133	423	13	:	:	PUNCT
ijpds-3133	423	14	a	a	DET
ijpds-3133	423	15	potential	potential	ADJ
ijpds-3133	423	16	ophthalmic	ophthalmic	ADJ
ijpds-3133	423	17	drug	drug	NOUN
ijpds-3133	423	18	delivery	delivery	NOUN
ijpds-3133	423	19	vehicle	vehicle	NOUN
ijpds-3133	423	20	.	.	PUNCT
ijpds-3133	424	1	int	int	PROPN
ijpds-3133	424	2	j	j	PROPN
ijpds-3133	424	3	pharm	pharm	PROPN
ijpds-3133	424	4	.	.	PUNCT
ijpds-3133	425	1	2005	2005	NUM
ijpds-3133	425	2	;	;	PUNCT
ijpds-3133	426	1	292:95	292:95	PROPN
ijpds-3133	426	2	-	-	SYM
ijpds-3133	426	3	117	117	NUM
ijpds-3133	426	4	.	.	NOUN
ijpds-3133	426	5	35	35	NUM
ijpds-3133	426	6	.	.	PUNCT
ijpds-3133	427	1	li	li	PROPN
ijpds-3133	427	2	cc	cc	PROPN
ijpds-3133	427	3	,	,	PUNCT
ijpds-3133	427	4	abrahamson	abrahamson	PROPN
ijpds-3133	427	5	m	m	PROPN
ijpds-3133	427	6	,	,	PUNCT
ijpds-3133	427	7	kapoor	kapoor	PROPN
ijpds-3133	427	8	y	y	PROPN
ijpds-3133	427	9	,	,	PUNCT
ijpds-3133	427	10	et	et	PROPN
ijpds-3133	427	11	al	al	PROPN
ijpds-3133	427	12	.	.	PROPN
ijpds-3133	427	13	timolol	timolol	PROPN
ijpds-3133	427	14	transport	transport	NOUN
ijpds-3133	427	15	from	from	ADP
ijpds-3133	427	16	micro	micro	ADJ
ijpds-3133	427	17	emulsion	emulsion	NOUN
ijpds-3133	427	18	trapped	trap	VERB
ijpds-3133	427	19	in	in	ADP
ijpds-3133	427	20	hema	hema	PROPN
ijpds-3133	427	21	gels	gel	NOUN
ijpds-3133	427	22	.	.	PUNCT
ijpds-3133	428	1	j	j	PROPN
ijpds-3133	428	2	colloid	colloid	PROPN
ijpds-3133	428	3	interface	interface	PROPN
ijpds-3133	428	4	sci	sci	PROPN
ijpds-3133	428	5	.	.	PROPN
ijpds-3133	428	6	2007	2007	NUM
ijpds-3133	428	7	;	;	PUNCT
ijpds-3133	428	8	315:297	315:297	PROPN
ijpds-3133	428	9	-	-	PUNCT
ijpds-3133	428	10	306	306	NUM
ijpds-3133	428	11	.	.	PUNCT
ijpds-3133	429	1	36	36	NUM
ijpds-3133	429	2	.	.	PUNCT
ijpds-3133	429	3	ciolino	ciolino	PROPN
ijpds-3133	429	4	jb	jb	PROPN
ijpds-3133	429	5	,	,	PUNCT
ijpds-3133	429	6	stefanescu	stefanescu	PROPN
ijpds-3133	429	7	cf	cf	PROPN
ijpds-3133	429	8	,	,	PUNCT
ijpds-3133	429	9	ross	ross	PROPN
ijpds-3133	429	10	ae	ae	PROPN
ijpds-3133	429	11	,	,	PUNCT
ijpds-3133	429	12	et	et	PROPN
ijpds-3133	429	13	al	al	PROPN
ijpds-3133	429	14	.	.	PROPN
ijpds-3133	430	1	in	in	ADP
ijpds-3133	430	2	vivo	vivo	ADJ
ijpds-3133	430	3	performance	performance	NOUN
ijpds-3133	430	4	of	of	ADP
ijpds-3133	430	5	a	a	DET
ijpds-3133	430	6	drug	drug	NOUN
ijpds-3133	430	7	eluting	eluting	NOUN
ijpds-3133	430	8	contact	contact	NOUN
ijpds-3133	430	9	lens	len	NOUN
ijpds-3133	430	10	to	to	PART
ijpds-3133	430	11	treat	treat	VERB
ijpds-3133	430	12	glaucoma	glaucoma	NOUN
ijpds-3133	430	13	for	for	ADP
ijpds-3133	430	14	a	a	DET
ijpds-3133	430	15	month	month	NOUN
ijpds-3133	430	16	.	.	PUNCT
ijpds-3133	431	1	biomaterials	biomaterial	NOUN
ijpds-3133	431	2	.	.	PUNCT
ijpds-3133	432	1	2014	2014	NUM
ijpds-3133	432	2	;	;	PUNCT
ijpds-3133	432	3	35:432	35:432	NUM
ijpds-3133	432	4	-	-	SYM
ijpds-3133	432	5	39	39	NUM
ijpds-3133	432	6	.	.	PUNCT
ijpds-3133	433	1	37	37	NUM
ijpds-3133	433	2	.	.	PUNCT
ijpds-3133	434	1	kim	kim	PROPN
ijpds-3133	434	2	hj	hj	PROPN
ijpds-3133	434	3	,	,	PUNCT
ijpds-3133	434	4	zhang	zhang	PROPN
ijpds-3133	434	5	k	k	PROPN
ijpds-3133	434	6	,	,	PUNCT
ijpds-3133	434	7	moore	moore	PROPN
ijpds-3133	434	8	l	l	PROPN
ijpds-3133	434	9	,	,	PUNCT
ijpds-3133	434	10	et	et	PROPN
ijpds-3133	434	11	al	al	PROPN
ijpds-3133	434	12	.	.	PROPN
ijpds-3133	434	13	diamond	diamond	PROPN
ijpds-3133	434	14	nano	nano	NOUN
ijpds-3133	434	15	gel	gel	NOUN
ijpds-3133	434	16	embedded	embed	VERB
ijpds-3133	434	17	contact	contact	NOUN
ijpds-3133	434	18	lenses	lense	NOUN
ijpds-3133	434	19	mediate	mediate	VERB
ijpds-3133	434	20	lysozyme	lysozyme	NOUN
ijpds-3133	434	21	dependent	dependent	ADJ
ijpds-3133	434	22	therapeutic	therapeutic	ADJ
ijpds-3133	434	23	release	release	NOUN
ijpds-3133	434	24	.	.	PUNCT
ijpds-3133	435	1	acs	acs	PROPN
ijpds-3133	435	2	nano	nano	PROPN
ijpds-3133	435	3	.	.	PUNCT
ijpds-3133	436	1	2014	2014	NUM
ijpds-3133	436	2	;	;	PUNCT
ijpds-3133	436	3	8:2998	8:2998	NUM
ijpds-3133	436	4	-	-	SYM
ijpds-3133	436	5	3005	3005	NUM
ijpds-3133	436	6	.	.	PUNCT
ijpds-3133	437	1	38	38	NUM
ijpds-3133	437	2	.	.	PUNCT
ijpds-3133	438	1	clinicaltrials.gov	clinicaltrials.gov	X
ijpds-3133	438	2	.	.	PUNCT
ijpds-3133	439	1	a	a	DET
ijpds-3133	439	2	safety	safety	NOUN
ijpds-3133	439	3	and	and	CCONJ
ijpds-3133	439	4	efficacy	efficacy	NOUN
ijpds-3133	439	5	study	study	NOUN
ijpds-3133	439	6	of	of	ADP
ijpds-3133	439	7	brimonidine	brimonidine	PROPN
ijpds-3133	439	8	intravitreal	intravitreal	NOUN
ijpds-3133	439	9	implant	implant	ADJ
ijpds-3133	439	10	in	in	ADP
ijpds-3133	439	11	geographic	geographic	ADJ
ijpds-3133	439	12	atrophy	atrophy	NOUN
ijpds-3133	439	13	secondary	secondary	ADJ
ijpds-3133	439	14	to	to	ADP
ijpds-3133	439	15	agerelated	agerelate	VERB
ijpds-3133	439	16	macular	macular	ADJ
ijpds-3133	439	17	degeneration	degeneration	NOUN
ijpds-3133	439	18	(	(	PUNCT
ijpds-3133	439	19	beacon	beacon	NOUN
ijpds-3133	439	20	)	)	PUNCT
ijpds-3133	439	21	.	.	PUNCT
ijpds-3133	440	1	https://clinicaltrials.gov/ct2/show/nct02087	https://clinicaltrials.gov/ct2/show/nct02087	NOUN
ijpds-3133	440	2	085	085	NUM
ijpds-3133	440	3	.	.	NOUN
ijpds-3133	441	1	39	39	NUM
ijpds-3133	441	2	.	.	PUNCT
ijpds-3133	442	1	clinicaltrials.gov	clinicaltrials.gov	X
ijpds-3133	442	2	.	.	PUNCT
ijpds-3133	443	1	a	a	DET
ijpds-3133	443	2	phase	phase	NOUN
ijpds-3133	443	3	1/2	1/2	NUM
ijpds-3133	443	4	multicenter	multicenter	NOUN
ijpds-3133	443	5	,	,	PUNCT
ijpds-3133	443	6	randomized	randomize	VERB
ijpds-3133	443	7	,	,	PUNCT
ijpds-3133	443	8	study	study	NOUN
ijpds-3133	443	9	to	to	PART
ijpds-3133	443	10	evaluate	evaluate	VERB
ijpds-3133	443	11	the	the	DET
ijpds-3133	443	12	safety	safety	NOUN
ijpds-3133	443	13	and	and	CCONJ
ijpds-3133	443	14	efficacy	efficacy	NOUN
ijpds-3133	443	15	of	of	ADP
ijpds-3133	443	16	vs101	vs101	PROPN
ijpds-3133	443	17	sub	sub	PROPN
ijpds-3133	443	18	conjunctival	conjunctival	NOUN
ijpds-3133	443	19	latanoprost	latanoprost	ADJ
ijpds-3133	443	20	insert	insert	NOUN
ijpds-3133	443	21	in	in	ADP
ijpds-3133	443	22	subjects	subject	NOUN
ijpds-3133	443	23	with	with	ADP
ijpds-3133	443	24	openangle	openangle	NOUN
ijpds-3133	443	25	glaucoma	glaucoma	NOUN
ijpds-3133	443	26	or	or	CCONJ
ijpds-3133	443	27	ocular	ocular	ADJ
ijpds-3133	443	28	hypertension	hypertension	NOUN
ijpds-3133	443	29	.	.	PUNCT
ijpds-3133	444	1	40	40	NUM
ijpds-3133	444	2	.	.	PUNCT
ijpds-3133	445	1	ng	ng	PROPN
ijpds-3133	445	2	xw	xw	PROPN
ijpds-3133	445	3	,	,	PUNCT
ijpds-3133	445	4	liu	liu	PROPN
ijpds-3133	445	5	kl	kl	PROPN
ijpds-3133	445	6	,	,	PUNCT
ijpds-3133	445	7	veluchamy	veluchamy	PROPN
ijpds-3133	445	8	ab	ab	PROPN
ijpds-3133	445	9	,	,	PUNCT
ijpds-3133	445	10	et	et	PROPN
ijpds-3133	445	11	al	al	PROPN
ijpds-3133	445	12	.	.	PUNCT
ijpds-3133	446	1	a	a	DET
ijpds-3133	446	2	biodegradable	biodegradable	ADJ
ijpds-3133	446	3	ocular	ocular	ADJ
ijpds-3133	446	4	implant	implant	NOUN
ijpds-3133	446	5	for	for	ADP
ijpds-3133	446	6	long	long	ADJ
ijpds-3133	446	7	-	-	PUNCT
ijpds-3133	446	8	term	term	NOUN
ijpds-3133	446	9	suppression	suppression	NOUN
ijpds-3133	446	10	of	of	ADP
ijpds-3133	446	11	intraocular	intraocular	ADJ
ijpds-3133	446	12	pressure	pressure	NOUN
ijpds-3133	446	13	.	.	PUNCT
ijpds-3133	447	1	drug	drug	NOUN
ijpds-3133	447	2	deliv	deliv	PROPN
ijpds-3133	447	3	transl	transl	PROPN
ijpds-3133	447	4	res	re	NOUN
ijpds-3133	447	5	2015	2015	NUM
ijpds-3133	447	6	;	;	PUNCT
ijpds-3133	447	7	5	5	NUM
ijpds-3133	447	8	:	:	PUNCT
ijpds-3133	447	9	469–479	469–479	NUM
ijpds-3133	447	10	.	.	NOUN
ijpds-3133	448	1	41	41	NUM
ijpds-3133	448	2	.	.	PUNCT
ijpds-3133	449	1	manickavasagam	manickavasagam	PROPN
ijpds-3133	450	1	d	d	X
ijpds-3133	450	2	,	,	PUNCT
ijpds-3133	450	3	wehrung	wehrung	PROPN
ijpds-3133	450	4	d	d	PROPN
ijpds-3133	450	5	,	,	PUNCT
ijpds-3133	450	6	chamsaz	chamsaz	PROPN
ijpds-3133	450	7	ea	ea	PROPN
ijpds-3133	450	8	,	,	PUNCT
ijpds-3133	450	9	et	et	PROPN
ijpds-3133	450	10	al	al	PROPN
ijpds-3133	450	11	.	.	PROPN
ijpds-3133	450	12	assessment	assessment	NOUN
ijpds-3133	450	13	of	of	ADP
ijpds-3133	450	14	alkoxylphenacyl	alkoxylphenacyl	NOUN
ijpds-3133	450	15	-	-	PUNCT
ijpds-3133	450	16	based	base	VERB
ijpds-3133	450	17	polycarbonates	polycarbonate	NOUN
ijpds-3133	450	18	as	as	ADP
ijpds-3133	450	19	a	a	DET
ijpds-3133	450	20	potential	potential	ADJ
ijpds-3133	450	21	platform	platform	NOUN
ijpds-3133	450	22	for	for	ADP
ijpds-3133	450	23	controlled	control	VERB
ijpds-3133	450	24	delivery	delivery	NOUN
ijpds-3133	450	25	of	of	ADP
ijpds-3133	450	26	a	a	DET
ijpds-3133	450	27	model	model	ADJ
ijpds-3133	450	28	anti	anti	ADJ
ijpds-3133	450	29	-	-	ADJ
ijpds-3133	450	30	glaucoma	glaucoma	ADJ
ijpds-3133	450	31	drug	drug	NOUN
ijpds-3133	450	32	.	.	PUNCT
ijpds-3133	451	1	eur	eur	PROPN
ijpds-3133	451	2	j	j	PROPN
ijpds-3133	451	3	pharm	pharm	PROPN
ijpds-3133	451	4	biopharm	biopharm	PROPN
ijpds-3133	451	5	2016	2016	NUM
ijpds-3133	451	6	;	;	PUNCT
ijpds-3133	451	7	107	107	NUM
ijpds-3133	451	8	:	:	PUNCT
ijpds-3133	451	9	56–66	56–66	NUM
ijpds-3133	451	10	.	.	PUNCT
ijpds-3133	451	11	42	42	NUM
ijpds-3133	451	12	.	.	PUNCT
ijpds-3133	452	1	saati	saati	PROPN
ijpds-3133	452	2	s	s	PROPN
ijpds-3133	452	3	,	,	PUNCT
ijpds-3133	452	4	lo	lo	PROPN
ijpds-3133	452	5	r	r	PROPN
ijpds-3133	452	6	,	,	PUNCT
ijpds-3133	452	7	li	li	PROPN
ijpds-3133	452	8	p	p	PROPN
ijpds-3133	452	9	-	-	PUNCT
ijpds-3133	452	10	y	y	PROPN
ijpds-3133	452	11	,	,	PUNCT
ijpds-3133	452	12	et	et	PROPN
ijpds-3133	452	13	al	al	PROPN
ijpds-3133	452	14	.	.	PUNCT
ijpds-3133	452	15	mini	mini	ADJ
ijpds-3133	452	16	drug	drug	NOUN
ijpds-3133	452	17	pump	pump	NOUN
ijpds-3133	452	18	for	for	ADP
ijpds-3133	452	19	ophthalmic	ophthalmic	ADJ
ijpds-3133	452	20	use	use	NOUN
ijpds-3133	452	21	.	.	PUNCT
ijpds-3133	453	1	trans	tran	NOUN
ijpds-3133	453	2	am	be	AUX
ijpds-3133	453	3	ophthalmol	ophthalmol	PROPN
ijpds-3133	453	4	soc	soc	NOUN
ijpds-3133	453	5	.	.	PUNCT
ijpds-3133	454	1	2009	2009	NUM
ijpds-3133	454	2	;	;	PUNCT
ijpds-3133	454	3	107	107	NUM
ijpds-3133	454	4	:	:	PUNCT
ijpds-3133	454	5	60–70	60–70	NUM
ijpds-3133	454	6	.	.	PUNCT
ijpds-3133	455	1	43	43	NUM
ijpds-3133	455	2	.	.	PUNCT
ijpds-3133	456	1	natarajan	natarajan	PROPN
ijpds-3133	456	2	jv	jv	PROPN
ijpds-3133	456	3	,	,	PUNCT
ijpds-3133	456	4	ang	ang	PROPN
ijpds-3133	456	5	m	m	PROPN
ijpds-3133	456	6	,	,	PUNCT
ijpds-3133	456	7	darwitan	darwitan	PROPN
ijpds-3133	456	8	a	a	PRON
ijpds-3133	456	9	,	,	PUNCT
ijpds-3133	456	10	et	et	PROPN
ijpds-3133	456	11	al	al	PROPN
ijpds-3133	456	12	.	.	PROPN
ijpds-3133	456	13	nanomedicine	nanomedicine	PROPN
ijpds-3133	456	14	for	for	ADP
ijpds-3133	456	15	glaucoma	glaucoma	NOUN
ijpds-3133	456	16	:	:	PUNCT
ijpds-3133	456	17	liposomes	liposome	NOUN
ijpds-3133	456	18	provide	provide	VERB
ijpds-3133	456	19	sustained	sustained	ADJ
ijpds-3133	456	20	release	release	NOUN
ijpds-3133	456	21	of	of	ADP
ijpds-3133	456	22	latanoprost	latanoprost	ADJ
ijpds-3133	456	23	in	in	ADP
ijpds-3133	456	24	the	the	DET
ijpds-3133	456	25	eye	eye	NOUN
ijpds-3133	456	26	.	.	PUNCT
ijpds-3133	457	1	int	int	PROPN
ijpds-3133	457	2	j	j	PROPN
ijpds-3133	457	3	nanomedicine	nanomedicine	PROPN
ijpds-3133	457	4	.	.	PUNCT
ijpds-3133	458	1	2012	2012	NUM
ijpds-3133	458	2	;	;	PUNCT
ijpds-3133	458	3	7	7	NUM
ijpds-3133	458	4	:	:	SYM
ijpds-3133	458	5	123–131	123–131	NUM
ijpds-3133	458	6	44	44	NUM
ijpds-3133	458	7	.	.	PUNCT
ijpds-3133	459	1	monem	monem	PROPN
ijpds-3133	459	2	as	as	ADP
ijpds-3133	459	3	,	,	PUNCT
ijpds-3133	459	4	ali	ali	PROPN
ijpds-3133	459	5	fm	fm	PROPN
ijpds-3133	459	6	,	,	PUNCT
ijpds-3133	459	7	ismail	ismail	PROPN
ijpds-3133	459	8	mw	mw	PROPN
ijpds-3133	459	9	.	.	PROPN
ijpds-3133	459	10	prolonged	prolonged	ADJ
ijpds-3133	459	11	effect	effect	NOUN
ijpds-3133	459	12	of	of	ADP
ijpds-3133	459	13	liposomes	liposome	NOUN
ijpds-3133	459	14	encapsulating	encapsulate	VERB
ijpds-3133	459	15	pilocarpine	pilocarpine	PROPN
ijpds-3133	459	16	hcl	hcl	PROPN
ijpds-3133	459	17	in	in	ADP
ijpds-3133	459	18	normal	normal	ADJ
ijpds-3133	459	19	and	and	CCONJ
ijpds-3133	459	20	glaucomatous	glaucomatous	ADJ
ijpds-3133	459	21	rabbits	rabbit	NOUN
ijpds-3133	459	22	.	.	PUNCT
ijpds-3133	460	1	int	int	NOUN
ijpds-3133	460	2	j	j	PROPN
ijpds-3133	460	3	pharm	pharm	PROPN
ijpds-3133	460	4	.	.	PUNCT
ijpds-3133	461	1	2000	2000	NUM
ijpds-3133	461	2	;	;	PUNCT
ijpds-3133	461	3	198	198	NUM
ijpds-3133	461	4	:	:	PUNCT
ijpds-3133	461	5	29–38	29–38	NUM
ijpds-3133	461	6	.	.	PUNCT
ijpds-3133	462	1	45	45	NUM
ijpds-3133	462	2	.	.	PUNCT
ijpds-3133	463	1	zarbin	zarbin	PROPN
ijpds-3133	463	2	ma	ma	PROPN
ijpds-3133	463	3	,	,	PUNCT
ijpds-3133	463	4	montemagno	montemagno	PROPN
ijpds-3133	463	5	c	c	PROPN
ijpds-3133	463	6	,	,	PUNCT
ijpds-3133	463	7	leary	leary	PROPN
ijpds-3133	463	8	jf	jf	PROPN
ijpds-3133	463	9	,	,	PUNCT
ijpds-3133	463	10	et	et	PROPN
ijpds-3133	463	11	al	al	PROPN
ijpds-3133	463	12	.	.	PROPN
ijpds-3133	463	13	nanotechnology	nanotechnology	PROPN
ijpds-3133	463	14	in	in	ADP
ijpds-3133	463	15	ophthalmology	ophthalmology	NOUN
ijpds-3133	463	16	.	.	PUNCT
ijpds-3133	464	1	can	can	AUX
ijpds-3133	464	2	j	j	PROPN
ijpds-3133	464	3	ophthalmol	ophthalmol	PROPN
ijpds-3133	464	4	.	.	PUNCT
ijpds-3133	465	1	2010	2010	NUM
ijpds-3133	465	2	;	;	PUNCT
ijpds-3133	465	3	45	45	NUM
ijpds-3133	465	4	:	:	SYM
ijpds-3133	465	5	457–476	457–476	NUM
ijpds-3133	465	6	.	.	NOUN
ijpds-3133	465	7	46	46	NUM
ijpds-3133	465	8	.	.	PUNCT
ijpds-3133	466	1	mehta	mehta	PROPN
ijpds-3133	466	2	p	p	PROPN
ijpds-3133	466	3	,	,	PUNCT
ijpds-3133	466	4	al	al	PROPN
ijpds-3133	466	5	-	-	PUNCT
ijpds-3133	466	6	kinani	kinani	PROPN
ijpds-3133	466	7	aa	aa	PROPN
ijpds-3133	466	8	,	,	PUNCT
ijpds-3133	466	9	haj	haj	PROPN
ijpds-3133	466	10	-	-	PUNCT
ijpds-3133	466	11	ahmad	ahmad	ADJ
ijpds-3133	466	12	r	r	NOUN
ijpds-3133	466	13	,	,	PUNCT
ijpds-3133	466	14	et	et	PROPN
ijpds-3133	466	15	al	al	PROPN
ijpds-3133	466	16	.	.	PROPN
ijpds-3133	466	17	electrically	electrically	PROPN
ijpds-3133	466	18	atomised	atomise	VERB
ijpds-3133	466	19	formulations	formulation	NOUN
ijpds-3133	466	20	of	of	ADP
ijpds-3133	466	21	timolol	timolol	NOUN
ijpds-3133	466	22	maleate	maleate	NOUN
ijpds-3133	466	23	for	for	ADP
ijpds-3133	466	24	direct	direct	ADJ
ijpds-3133	466	25	and	and	CCONJ
ijpds-3133	466	26	ondemand	ondemand	NOUN
ijpds-3133	466	27	ocular	ocular	ADJ
ijpds-3133	466	28	lens	lens	NOUN
ijpds-3133	466	29	coatings	coating	NOUN
ijpds-3133	466	30	.	.	PUNCT
ijpds-3133	467	1	eur	eur	PROPN
ijpds-3133	467	2	j	j	PROPN
ijpds-3133	467	3	pharm	pharm	PROPN
ijpds-3133	467	4	biopharm	biopharm	PROPN
ijpds-3133	467	5	2017	2017	NUM
ijpds-3133	467	6	;	;	PUNCT
ijpds-3133	467	7	119	119	NUM
ijpds-3133	467	8	:	:	PUNCT
ijpds-3133	467	9	170–184	170–184	NUM
ijpds-3133	467	10	.	.	PUNCT
ijpds-3133	468	1	47	47	NUM
ijpds-3133	468	2	.	.	PUNCT
ijpds-3133	469	1	ibrahim	ibrahim	PROPN
ijpds-3133	469	2	ka	ka	PROPN
ijpds-3133	469	3	,	,	PUNCT
ijpds-3133	469	4	el	el	PROPN
ijpds-3133	469	5	-	-	PUNCT
ijpds-3133	469	6	eswed	eswe	VERB
ijpds-3133	469	7	bi	bi	NOUN
ijpds-3133	469	8	,	,	PUNCT
ijpds-3133	469	9	abu	abu	PROPN
ijpds-3133	469	10	-	-	PUNCT
ijpds-3133	469	11	sbeih	sbeih	PROPN
ijpds-3133	469	12	ka	ka	PROPN
ijpds-3133	469	13	,	,	PUNCT
ijpds-3133	469	14	et	et	PROPN
ijpds-3133	469	15	al	al	PROPN
ijpds-3133	469	16	.	.	PUNCT
ijpds-3133	469	17	preparation	preparation	NOUN
ijpds-3133	469	18	of	of	ADP
ijpds-3133	469	19	chito	chito	PROPN
ijpds-3133	469	20	-	-	NOUN
ijpds-3133	469	21	oligomers	oligomer	NOUN
ijpds-3133	469	22	by	by	ADP
ijpds-3133	469	23	hydrolysis	hydrolysis	NOUN
ijpds-3133	469	24	of	of	ADP
ijpds-3133	469	25	chitosan	chitosan	NOUN
ijpds-3133	469	26	in	in	ADP
ijpds-3133	469	27	the	the	DET
ijpds-3133	469	28	presence	presence	NOUN
ijpds-3133	469	29	of	of	ADP
ijpds-3133	469	30	zeolite	zeolite	NOUN
ijpds-3133	469	31	as	as	ADP
ijpds-3133	469	32	adsorbent	adsorbent	NOUN
ijpds-3133	469	33	.	.	PUNCT
ijpds-3133	470	1	mar	mar	PROPN
ijpds-3133	470	2	drugs	drug	NOUN
ijpds-3133	470	3	2016	2016	NUM
ijpds-3133	470	4	;	;	PUNCT
ijpds-3133	470	5	14	14	NUM
ijpds-3133	470	6	:	:	SYM
ijpds-3133	470	7	43	43	NUM
ijpds-3133	470	8	.	.	PUNCT
ijpds-3133	470	9	48	48	NUM
ijpds-3133	470	10	.	.	PUNCT
ijpds-3133	471	1	li	li	PROPN
ijpds-3133	471	2	j	j	PROPN
ijpds-3133	471	3	,	,	PUNCT
ijpds-3133	471	4	tian	tian	PROPN
ijpds-3133	471	5	s	s	PROPN
ijpds-3133	471	6	,	,	PUNCT
ijpds-3133	471	7	tao	tao	PROPN
ijpds-3133	471	8	q	q	PROPN
ijpds-3133	471	9	,	,	PUNCT
ijpds-3133	471	10	et	et	PROPN
ijpds-3133	471	11	al	al	PROPN
ijpds-3133	471	12	.	.	PROPN
ijpds-3133	471	13	montmorillonite	montmorillonite	PROPN
ijpds-3133	471	14	/	/	SYM
ijpds-3133	471	15	chitosan	chitosan	ADJ
ijpds-3133	471	16	nanoparticles	nanoparticle	NOUN
ijpds-3133	471	17	as	as	ADP
ijpds-3133	471	18	a	a	DET
ijpds-3133	471	19	novel	novel	ADJ
ijpds-3133	471	20	controlled	control	VERB
ijpds-3133	471	21	-	-	PUNCT
ijpds-3133	471	22	release	release	NOUN
ijpds-3133	471	23	topical	topical	ADJ
ijpds-3133	471	24	ophthalmic	ophthalmic	ADJ
ijpds-3133	471	25	delivery	delivery	NOUN
ijpds-3133	471	26	system	system	NOUN
ijpds-3133	471	27	for	for	ADP
ijpds-3133	471	28	the	the	DET
ijpds-3133	471	29	treatment	treatment	NOUN
ijpds-3133	471	30	of	of	ADP
ijpds-3133	471	31	glaucoma	glaucoma	NOUN
ijpds-3133	471	32	.	.	PUNCT
ijpds-3133	472	1	int	int	NOUN
ijpds-3133	472	2	j	j	PROPN
ijpds-3133	472	3	nanomedicine	nanomedicine	PROPN
ijpds-3133	472	4	.	.	PUNCT
ijpds-3133	473	1	2018	2018	NUM
ijpds-3133	473	2	;	;	PUNCT
ijpds-3133	474	1	13	13	NUM
ijpds-3133	474	2	:	:	SYM
ijpds-3133	474	3	3975–87	3975–87	NUM
ijpds-3133	474	4	.	.	PUNCT
ijpds-3133	475	1	49	49	NUM
ijpds-3133	475	2	.	.	PUNCT
ijpds-3133	476	1	zhao	zhao	PROPN
ijpds-3133	476	2	r	r	PROPN
ijpds-3133	476	3	,	,	PUNCT
ijpds-3133	476	4	li	li	PROPN
ijpds-3133	476	5	j	j	PROPN
ijpds-3133	476	6	,	,	PUNCT
ijpds-3133	476	7	wang	wang	PROPN
ijpds-3133	476	8	j	j	PROPN
ijpds-3133	476	9	,	,	PUNCT
ijpds-3133	476	10	et	et	PROPN
ijpds-3133	476	11	al	al	PROPN
ijpds-3133	476	12	.	.	PUNCT
ijpds-3133	476	13	development	development	NOUN
ijpds-3133	476	14	of	of	ADP
ijpds-3133	476	15	timololloaded	timololloade	VERB
ijpds-3133	476	16	galactosylated	galactosylated	ADJ
ijpds-3133	476	17	chitosan	chitosan	ADJ
ijpds-3133	476	18	nanoparticles	nanoparticle	NOUN
ijpds-3133	476	19	and	and	CCONJ
ijpds-3133	476	20	evaluation	evaluation	NOUN
ijpds-3133	476	21	of	of	ADP
ijpds-3133	476	22	their	their	PRON
ijpds-3133	476	23	potential	potential	NOUN
ijpds-3133	476	24	for	for	ADP
ijpds-3133	476	25	ocular	ocular	ADJ
ijpds-3133	476	26	drug	drug	NOUN
ijpds-3133	476	27	delivery	delivery	NOUN
ijpds-3133	476	28	.	.	PUNCT
ijpds-3133	477	1	aaps	aap	NOUN
ijpds-3133	477	2	pharm	pharm	VERB
ijpds-3133	477	3	sci	sci	PROPN
ijpds-3133	477	4	tech	tech	NOUN
ijpds-3133	477	5	.	.	PUNCT
ijpds-3133	478	1	2017	2017	NUM
ijpds-3133	478	2	;	;	PUNCT
ijpds-3133	478	3	18	18	NUM
ijpds-3133	478	4	:	:	SYM
ijpds-3133	478	5	997–1008	997–1008	NOUN
ijpds-3133	478	6	.	.	NOUN
ijpds-3133	479	1	50	50	NUM
ijpds-3133	479	2	.	.	PUNCT
ijpds-3133	480	1	mehta	mehta	PROPN
ijpds-3133	480	2	p	p	PROPN
ijpds-3133	480	3	,	,	PUNCT
ijpds-3133	480	4	al	al	PROPN
ijpds-3133	480	5	-	-	PUNCT
ijpds-3133	480	6	kinani	kinani	PROPN
ijpds-3133	480	7	aa	aa	PROPN
ijpds-3133	480	8	,	,	PUNCT
ijpds-3133	480	9	arshad	arshad	PROPN
ijpds-3133	480	10	ms	ms	PROPN
ijpds-3133	480	11	,	,	PUNCT
ijpds-3133	480	12	et	et	PROPN
ijpds-3133	480	13	al	al	PROPN
ijpds-3133	480	14	.	.	PUNCT
ijpds-3133	480	15	engineering	engineering	PROPN
ijpds-3133	480	16	and	and	CCONJ
ijpds-3133	480	17	development	development	NOUN
ijpds-3133	480	18	of	of	ADP
ijpds-3133	480	19	chitosan	chitosan	NOUN
ijpds-3133	480	20	-	-	PUNCT
ijpds-3133	480	21	based	base	VERB
ijpds-3133	480	22	nanocoatings	nanocoating	NOUN
ijpds-3133	480	23	for	for	ADP
ijpds-3133	480	24	ocular	ocular	ADJ
ijpds-3133	480	25	contact	contact	NOUN
ijpds-3133	480	26	lenses	lense	NOUN
ijpds-3133	480	27	.	.	PUNCT
ijpds-3133	481	1	j	j	PROPN
ijpds-3133	481	2	pharm	pharm	PROPN
ijpds-3133	481	3	sci	sci	PROPN
ijpds-3133	481	4	.	.	PROPN
ijpds-3133	481	5	2019	2019	NUM
ijpds-3133	481	6	;	;	PUNCT
ijpds-3133	481	7	108	108	NUM
ijpds-3133	481	8	:	:	SYM
ijpds-3133	481	9	1540–51	1540–51	NUM
ijpds-3133	481	10	.	.	PUNCT
ijpds-3133	481	11	https://clinicaltrials.gov/ct2/show/nct02087085	https://clinicaltrials.gov/ct2/show/nct02087085	NOUN
ijpds-3133	481	12	https://clinicaltrials.gov/ct2/show/nct02087085	https://clinicaltrials.gov/ct2/show/nct02087085	PUNCT
ijpds-3133	481	13	https://clinicaltrials.gov/ct2/show/nct02087085	https://clinicaltrials.gov/ct2/show/nct02087085	X
ijpds-3133	481	14	rai	rai	X
ijpds-3133	481	15	et	et	PROPN
ijpds-3133	481	16	al	al	PROPN
ijpds-3133	481	17	mindful	mindful	ADJ
ijpds-3133	481	18	-	-	PUNCT
ijpds-3133	481	19	based	base	VERB
ijpds-3133	481	20	stress	stress	NOUN
ijpds-3133	481	21	reduction	reduction	NOUN
ijpds-3133	481	22	impact	impact	NOUN
ijpds-3133	481	23	vol	vol	NOUN
ijpds-3133	481	24	1	1	NUM
ijpds-3133	481	25	|	|	NOUN
ijpds-3133	481	26	issue	issue	NOUN
ijpds-3133	481	27	2	2	NUM
ijpds-3133	481	28	|	|	ADV
ijpds-3133	481	29	jul	jul	PROPN
ijpds-3133	481	30	–	–	PUNCT
ijpds-3133	481	31	sep	sep	PROPN
ijpds-3133	481	32	2022	2022	NUM
ijpds-3133	481	33	indian	indian	PROPN
ijpds-3133	481	34	j	j	PROPN
ijpds-3133	481	35	pharm	pharm	PROPN
ijpds-3133	481	36	drug	drug	PROPN
ijpds-3133	481	37	studies	study	NOUN
ijpds-3133	481	38	|	|	ADV
ijpds-3133	481	39	46	46	NUM
ijpds-3133	481	40	51	51	NUM
ijpds-3133	481	41	.	.	PUNCT
ijpds-3133	482	1	samadi	samadi	PROPN
ijpds-3133	482	2	n	n	CCONJ
ijpds-3133	482	3	,	,	PUNCT
ijpds-3133	482	4	abbadessa	abbadessa	PROPN
ijpds-3133	482	5	a	a	PRON
ijpds-3133	482	6	,	,	PUNCT
ijpds-3133	482	7	di	di	X
ijpds-3133	482	8	stefano	stefano	PROPN
ijpds-3133	482	9	a	a	PROPN
ijpds-3133	482	10	,	,	PUNCT
ijpds-3133	482	11	et	et	PROPN
ijpds-3133	482	12	al	al	PROPN
ijpds-3133	482	13	.	.	PUNCT
ijpds-3133	483	1	the	the	DET
ijpds-3133	483	2	effect	effect	NOUN
ijpds-3133	483	3	of	of	ADP
ijpds-3133	483	4	lauryl	lauryl	NOUN
ijpds-3133	483	5	capping	cap	VERB
ijpds-3133	483	6	group	group	NOUN
ijpds-3133	483	7	on	on	ADP
ijpds-3133	483	8	protein	protein	NOUN
ijpds-3133	483	9	release	release	NOUN
ijpds-3133	483	10	and	and	CCONJ
ijpds-3133	483	11	degradation	degradation	NOUN
ijpds-3133	483	12	of	of	ADP
ijpds-3133	483	13	poly	poly	ADJ
ijpds-3133	483	14	(	(	PUNCT
ijpds-3133	483	15	d	d	NOUN
ijpds-3133	483	16	,	,	PUNCT
ijpds-3133	483	17	l	l	NOUN
ijpds-3133	483	18	-	-	ADJ
ijpds-3133	483	19	lactic	lactic	ADJ
ijpds-3133	483	20	-	-	PUNCT
ijpds-3133	483	21	co	co	NOUN
ijpds-3133	483	22	-	-	ADJ
ijpds-3133	483	23	glycolic	glycolic	ADJ
ijpds-3133	483	24	acid	acid	NOUN
ijpds-3133	483	25	)	)	PUNCT
ijpds-3133	483	26	particles	particle	NOUN
ijpds-3133	483	27	.	.	PUNCT
ijpds-3133	484	1	j	j	PROPN
ijpds-3133	484	2	control	control	PROPN
ijpds-3133	484	3	release	release	PROPN
ijpds-3133	484	4	2013	2013	NUM
ijpds-3133	484	5	;	;	PUNCT
ijpds-3133	484	6	172	172	NUM
ijpds-3133	484	7	:	:	SYM
ijpds-3133	484	8	436–43	436–43	NUM
ijpds-3133	484	9	.	.	PUNCT
ijpds-3133	484	10	52	52	NUM
ijpds-3133	484	11	.	.	PUNCT
ijpds-3133	485	1	salama	salama	PROPN
ijpds-3133	485	2	ha	ha	INTJ
ijpds-3133	485	3	,	,	PUNCT
ijpds-3133	485	4	ghorab	ghorab	PROPN
ijpds-3133	485	5	m	m	PROPN
ijpds-3133	485	6	,	,	PUNCT
ijpds-3133	485	7	mahmoud	mahmoud	PROPN
ijpds-3133	485	8	aa	aa	PROPN
ijpds-3133	485	9	,	,	PUNCT
ijpds-3133	485	10	et	et	PROPN
ijpds-3133	485	11	al	al	PROPN
ijpds-3133	485	12	.	.	PROPN
ijpds-3133	485	13	plga	plga	NOUN
ijpds-3133	485	14	nanoparticles	nanoparticle	NOUN
ijpds-3133	485	15	as	as	ADP
ijpds-3133	485	16	subconjunctival	subconjunctival	ADJ
ijpds-3133	485	17	injection	injection	NOUN
ijpds-3133	485	18	for	for	ADP
ijpds-3133	485	19	management	management	NOUN
ijpds-3133	485	20	of	of	ADP
ijpds-3133	485	21	glaucoma	glaucoma	NOUN
ijpds-3133	485	22	.	.	PUNCT
ijpds-3133	486	1	aaps	aap	NOUN
ijpds-3133	486	2	pharm	pharm	PROPN
ijpds-3133	486	3	sci	sci	PROPN
ijpds-3133	486	4	tech	tech	NOUN
ijpds-3133	486	5	.	.	PUNCT
ijpds-3133	487	1	2017	2017	NUM
ijpds-3133	487	2	;	;	PUNCT
ijpds-3133	487	3	18	18	NUM
ijpds-3133	487	4	:	:	PUNCT
ijpds-3133	487	5	2517–28	2517–28	NUM
ijpds-3133	487	6	.	.	PUNCT
ijpds-3133	488	1	53	53	NUM
ijpds-3133	488	2	.	.	PUNCT
ijpds-3133	488	3	khan	khan	PROPN
ijpds-3133	488	4	n	n	CCONJ
ijpds-3133	488	5	,	,	PUNCT
ijpds-3133	488	6	ameeduzzafar	ameeduzzafar	PROPN
ijpds-3133	488	7	,	,	PUNCT
ijpds-3133	488	8	khanna	khanna	PROPN
ijpds-3133	488	9	k	k	PROPN
ijpds-3133	488	10	,	,	PUNCT
ijpds-3133	488	11	et	et	PROPN
ijpds-3133	488	12	al	al	PROPN
ijpds-3133	488	13	.	.	PUNCT
ijpds-3133	488	14	chitosan	chitosan	PROPN
ijpds-3133	488	15	coated	coat	VERB
ijpds-3133	488	16	plga	plga	NOUN
ijpds-3133	488	17	nanoparticles	nanoparticle	NOUN
ijpds-3133	488	18	amplify	amplify	VERB
ijpds-3133	488	19	the	the	DET
ijpds-3133	488	20	ocular	ocular	ADJ
ijpds-3133	488	21	hypotensive	hypotensive	ADJ
ijpds-3133	488	22	effect	effect	NOUN
ijpds-3133	488	23	of	of	ADP
ijpds-3133	488	24	forskolin	forskolin	NOUN
ijpds-3133	488	25	:	:	PUNCT
ijpds-3133	488	26	statistical	statistical	ADJ
ijpds-3133	488	27	design	design	NOUN
ijpds-3133	488	28	,	,	PUNCT
ijpds-3133	488	29	characterization	characterization	NOUN
ijpds-3133	488	30	and	and	CCONJ
ijpds-3133	488	31	in	in	ADP
ijpds-3133	488	32	vivo	vivo	ADJ
ijpds-3133	488	33	studies	study	NOUN
ijpds-3133	488	34	.	.	PUNCT
ijpds-3133	489	1	int	int	PROPN
ijpds-3133	489	2	j	j	PROPN
ijpds-3133	489	3	biol	biol	PROPN
ijpds-3133	489	4	macromol	macromol	PROPN
ijpds-3133	489	5	.	.	PUNCT
ijpds-3133	490	1	2018	2018	NUM
ijpds-3133	490	2	;	;	PUNCT
ijpds-3133	490	3	116	116	NUM
ijpds-3133	490	4	:	:	PUNCT
ijpds-3133	491	1	648–663	648–663	NUM
ijpds-3133	491	2	.	.	PUNCT
ijpds-3133	492	1	54	54	NUM
ijpds-3133	492	2	.	.	PUNCT
ijpds-3133	493	1	caprioli	caprioli	PROPN
ijpds-3133	493	2	j	j	PROPN
ijpds-3133	493	3	,	,	PUNCT
ijpds-3133	493	4	sears	sears	PROPN
ijpds-3133	493	5	m.	m.	NOUN
ijpds-3133	493	6	forskolin	forskolin	PROPN
ijpds-3133	493	7	lowers	lower	VERB
ijpds-3133	493	8	intraocular	intraocular	ADJ
ijpds-3133	493	9	pressure	pressure	NOUN
ijpds-3133	493	10	in	in	ADP
ijpds-3133	493	11	rabbits	rabbit	NOUN
ijpds-3133	493	12	,	,	PUNCT
ijpds-3133	493	13	monkeys	monkey	NOUN
ijpds-3133	493	14	,	,	PUNCT
ijpds-3133	493	15	and	and	CCONJ
ijpds-3133	493	16	man	man	NOUN
ijpds-3133	493	17	.	.	PUNCT
ijpds-3133	494	1	lancet	lancet	PROPN
ijpds-3133	494	2	.	.	PUNCT
ijpds-3133	495	1	2012	2012	NUM
ijpds-3133	495	2	;	;	PUNCT
ijpds-3133	495	3	1	1	NUM
ijpds-3133	495	4	:	:	PUNCT
ijpds-3133	495	5	958–60	958–60	NUM
ijpds-3133	495	6	.	.	PROPN
ijpds-3133	496	1	55	55	NUM
ijpds-3133	496	2	.	.	PUNCT
ijpds-3133	497	1	shokry	shokry	PROPN
ijpds-3133	497	2	m	m	PROPN
ijpds-3133	497	3	,	,	PUNCT
ijpds-3133	497	4	hathout	hathout	PROPN
ijpds-3133	497	5	rm	rm	PROPN
ijpds-3133	497	6	,	,	PUNCT
ijpds-3133	497	7	mansour	mansour	PROPN
ijpds-3133	497	8	s.	s.	PROPN
ijpds-3133	497	9	exploring	explore	VERB
ijpds-3133	497	10	gelatin	gelatin	NOUN
ijpds-3133	497	11	nanoparticles	nanoparticle	NOUN
ijpds-3133	497	12	as	as	ADP
ijpds-3133	497	13	novel	novel	ADJ
ijpds-3133	497	14	nano	nano	NOUN
ijpds-3133	497	15	-	-	PUNCT
ijpds-3133	497	16	carriers	carrier	NOUN
ijpds-3133	497	17	for	for	ADP
ijpds-3133	497	18	timolol	timolol	NOUN
ijpds-3133	497	19	maleate	maleate	NOUN
ijpds-3133	497	20	:	:	PUNCT
ijpds-3133	497	21	augmented	augment	VERB
ijpds-3133	497	22	in	in	ADP
ijpds-3133	497	23	-	-	PUNCT
ijpds-3133	497	24	vivo	vivo	NOUN
ijpds-3133	497	25	efficacy	efficacy	NOUN
ijpds-3133	497	26	and	and	CCONJ
ijpds-3133	497	27	safe	safe	ADJ
ijpds-3133	497	28	histological	histological	ADJ
ijpds-3133	497	29	profile	profile	NOUN
ijpds-3133	497	30	.	.	PUNCT
ijpds-3133	498	1	int	int	NOUN
ijpds-3133	498	2	j	j	PROPN
ijpds-3133	498	3	pharm	pharm	PROPN
ijpds-3133	498	4	.	.	PUNCT
ijpds-3133	499	1	2018	2018	NUM
ijpds-3133	499	2	;	;	PUNCT
ijpds-3133	500	1	545	545	NUM
ijpds-3133	500	2	:	:	PUNCT
ijpds-3133	500	3	229–239	229–239	NUM
ijpds-3133	500	4	.	.	PUNCT
ijpds-3133	501	1	56	56	NUM
ijpds-3133	501	2	.	.	PUNCT
ijpds-3133	501	3	liao	liao	PROPN
ijpds-3133	501	4	y	y	PROPN
ijpds-3133	501	5	,	,	PUNCT
ijpds-3133	501	6	te	te	PROPN
ijpds-3133	501	7	lee	lee	PROPN
ijpds-3133	501	8	ch	ch	PROPN
ijpds-3133	501	9	,	,	PUNCT
ijpds-3133	501	10	chen	chen	PROPN
ijpds-3133	501	11	st	st	PROPN
ijpds-3133	501	12	,	,	PUNCT
ijpds-3133	501	13	et	et	PROPN
ijpds-3133	501	14	al	al	PROPN
ijpds-3133	501	15	.	.	PUNCT
ijpds-3133	501	16	gelatin	gelatin	NOUN
ijpds-3133	501	17	-	-	PUNCT
ijpds-3133	501	18	functionalized	functionalize	VERB
ijpds-3133	501	19	mesoporous	mesoporous	ADJ
ijpds-3133	501	20	silica	silica	NOUN
ijpds-3133	501	21	nanoparticles	nanoparticle	NOUN
ijpds-3133	501	22	with	with	ADP
ijpds-3133	501	23	sustained	sustained	ADJ
ijpds-3133	501	24	release	release	NOUN
ijpds-3133	501	25	properties	property	NOUN
ijpds-3133	501	26	for	for	ADP
ijpds-3133	501	27	intracameral	intracameral	ADJ
ijpds-3133	501	28	pharmacotherapy	pharmacotherapy	NOUN
ijpds-3133	501	29	of	of	ADP
ijpds-3133	501	30	glaucoma	glaucoma	NOUN
ijpds-3133	501	31	.	.	PUNCT
ijpds-3133	502	1	j	j	PROPN
ijpds-3133	502	2	mater	mater	PROPN
ijpds-3133	502	3	chem	chem	PROPN
ijpds-3133	502	4	b.	b.	PROPN
ijpds-3133	502	5	2017	2017	NUM
ijpds-3133	502	6	;	;	PUNCT
ijpds-3133	502	7	5	5	NUM
ijpds-3133	502	8	:	:	PUNCT
ijpds-3133	502	9	7008–13	7008–13	NUM
ijpds-3133	502	10	.	.	X
ijpds-3133	502	11	57	57	NUM
ijpds-3133	502	12	.	.	PUNCT
ijpds-3133	502	13	jung	jung	PROPN
ijpds-3133	502	14	hj	hj	PROPN
ijpds-3133	502	15	,	,	PUNCT
ijpds-3133	502	16	abou	abou	PROPN
ijpds-3133	502	17	-	-	PUNCT
ijpds-3133	502	18	jaoude	jaoude	PROPN
ijpds-3133	502	19	m	m	PROPN
ijpds-3133	502	20	,	,	PUNCT
ijpds-3133	502	21	carbia	carbia	NOUN
ijpds-3133	502	22	be	be	VERB
ijpds-3133	502	23	,	,	PUNCT
ijpds-3133	502	24	et	et	PROPN
ijpds-3133	502	25	al	al	PROPN
ijpds-3133	502	26	.	.	PUNCT
ijpds-3133	502	27	glaucoma	glaucoma	NOUN
ijpds-3133	502	28	therapy	therapy	NOUN
ijpds-3133	502	29	by	by	ADP
ijpds-3133	502	30	extended	extended	ADJ
ijpds-3133	502	31	release	release	NOUN
ijpds-3133	502	32	of	of	ADP
ijpds-3133	502	33	timolol	timolol	NOUN
ijpds-3133	502	34	from	from	ADP
ijpds-3133	502	35	nanoparticle	nanoparticle	NOUN
ijpds-3133	502	36	loaded	load	VERB
ijpds-3133	502	37	siliconehydrogel	siliconehydrogel	NOUN
ijpds-3133	502	38	contact	contact	NOUN
ijpds-3133	502	39	lenses	lense	NOUN
ijpds-3133	502	40	.	.	PUNCT
ijpds-3133	503	1	j	j	PROPN
ijpds-3133	503	2	control	control	PROPN
ijpds-3133	503	3	release	release	PROPN
ijpds-3133	503	4	2013	2013	NUM
ijpds-3133	503	5	;	;	PUNCT
ijpds-3133	503	6	165	165	NUM
ijpds-3133	503	7	:	:	PUNCT
ijpds-3133	503	8	82–89	82–89	NUM
ijpds-3133	503	9	.	.	X
ijpds-3133	504	1	58	58	NUM
ijpds-3133	504	2	.	.	PUNCT
ijpds-3133	504	3	jung	jung	PROPN
ijpds-3133	504	4	hj	hj	PROPN
ijpds-3133	504	5	,	,	PUNCT
ijpds-3133	504	6	chauhan	chauhan	PROPN
ijpds-3133	504	7	a.	a.	NOUN
ijpds-3133	504	8	temperature	temperature	PROPN
ijpds-3133	504	9	sensitive	sensitive	ADJ
ijpds-3133	504	10	contact	contact	NOUN
ijpds-3133	504	11	lenses	lense	NOUN
ijpds-3133	504	12	for	for	ADP
ijpds-3133	504	13	triggered	trigger	VERB
ijpds-3133	504	14	ophthalmic	ophthalmic	ADJ
ijpds-3133	504	15	drug	drug	NOUN
ijpds-3133	504	16	delivery	delivery	NOUN
ijpds-3133	504	17	.	.	PUNCT
ijpds-3133	505	1	biomaterials	biomaterial	NOUN
ijpds-3133	505	2	.	.	PUNCT
ijpds-3133	506	1	2012	2012	NUM
ijpds-3133	506	2	;	;	PUNCT
ijpds-3133	506	3	33	33	NUM
ijpds-3133	506	4	:	:	SYM
ijpds-3133	506	5	2289–300	2289–300	ADJ
ijpds-3133	506	6	.	.	PUNCT
ijpds-3133	507	1	59	59	NUM
ijpds-3133	507	2	.	.	PUNCT
ijpds-3133	508	1	xu	xu	PROPN
ijpds-3133	508	2	j	j	PROPN
ijpds-3133	508	3	,	,	PUNCT
ijpds-3133	508	4	ge	ge	PROPN
ijpds-3133	508	5	y	y	PROPN
ijpds-3133	508	6	,	,	PUNCT
ijpds-3133	508	7	bu	bu	ADP
ijpds-3133	508	8	r	r	NOUN
ijpds-3133	508	9	,	,	PUNCT
ijpds-3133	508	10	et	et	PROPN
ijpds-3133	508	11	al	al	PROPN
ijpds-3133	508	12	.	.	PUNCT
ijpds-3133	509	1	co	co	NOUN
ijpds-3133	510	1	-	-	NOUN
ijpds-3133	511	1	delivery	delivery	NOUN
ijpds-3133	511	2	of	of	ADP
ijpds-3133	511	3	latanoprost	latanoprost	NOUN
ijpds-3133	511	4	and	and	CCONJ
ijpds-3133	511	5	timolol	timolol	VERB
ijpds-3133	511	6	from	from	ADP
ijpds-3133	511	7	micelles	micelle	NOUN
ijpds-3133	511	8	-	-	PUNCT
ijpds-3133	511	9	laden	laden	ADJ
ijpds-3133	511	10	contact	contact	NOUN
ijpds-3133	511	11	lenses	lense	NOUN
ijpds-3133	511	12	for	for	ADP
ijpds-3133	511	13	the	the	DET
ijpds-3133	511	14	treatment	treatment	NOUN
ijpds-3133	511	15	of	of	ADP
ijpds-3133	511	16	glaucoma	glaucoma	NOUN
ijpds-3133	511	17	.	.	PUNCT
ijpds-3133	512	1	j	j	PROPN
ijpds-3133	512	2	control	control	PROPN
ijpds-3133	512	3	rel	rel	PROPN
ijpds-3133	512	4	.	.	PUNCT
ijpds-3133	513	1	2019;305:18–28	2019;305:18–28	NUM
ijpds-3133	513	2	.	.	PROPN
ijpds-3133	514	1	60	60	NUM
ijpds-3133	514	2	.	.	PUNCT
ijpds-3133	515	1	cai	cai	PROPN
ijpds-3133	516	1	x	x	PROPN
ijpds-3133	516	2	,	,	PUNCT
ijpds-3133	516	3	conley	conley	PROPN
ijpds-3133	516	4	s	s	PROPN
ijpds-3133	516	5	,	,	PUNCT
ijpds-3133	516	6	naash	naash	ADJ
ijpds-3133	516	7	m.	m.	NOUN
ijpds-3133	516	8	nanoparticle	nanoparticle	NOUN
ijpds-3133	516	9	applications	application	NOUN
ijpds-3133	516	10	in	in	ADP
ijpds-3133	516	11	ocular	ocular	ADJ
ijpds-3133	516	12	gene	gene	NOUN
ijpds-3133	516	13	therapy	therapy	NOUN
ijpds-3133	516	14	.	.	PUNCT
ijpds-3133	517	1	vision	vision	NOUN
ijpds-3133	517	2	res	re	NOUN
ijpds-3133	517	3	.	.	PROPN
ijpds-3133	517	4	2008	2008	NUM
ijpds-3133	517	5	;	;	PUNCT
ijpds-3133	517	6	48	48	NUM
ijpds-3133	517	7	:	:	PUNCT
ijpds-3133	517	8	319–24	319–24	NUM
ijpds-3133	517	9	.	.	PUNCT
ijpds-3133	518	1	61	61	NUM
ijpds-3133	518	2	.	.	PUNCT
ijpds-3133	519	1	hillaireau	hillaireau	PROPN
ijpds-3133	519	2	h	h	PROPN
ijpds-3133	519	3	,	,	PUNCT
ijpds-3133	519	4	couvreur	couvreur	PROPN
ijpds-3133	519	5	p.	p.	PROPN
ijpds-3133	519	6	nanocarriers	nanocarrier	NOUN
ijpds-3133	519	7	’	'	PUNCT
ijpds-3133	519	8	entry	entry	NOUN
ijpds-3133	519	9	into	into	ADP
ijpds-3133	519	10	the	the	DET
ijpds-3133	519	11	cell	cell	NOUN
ijpds-3133	519	12	:	:	PUNCT
ijpds-3133	519	13	relevance	relevance	NOUN
ijpds-3133	519	14	to	to	ADP
ijpds-3133	519	15	drug	drug	NOUN
ijpds-3133	519	16	delivery	delivery	NOUN
ijpds-3133	519	17	.	.	PUNCT
ijpds-3133	520	1	cellular	cellular	ADJ
ijpds-3133	520	2	and	and	CCONJ
ijpds-3133	520	3	molecular	molecular	ADJ
ijpds-3133	520	4	life	life	NOUN
ijpds-3133	520	5	sciences	science	NOUN
ijpds-3133	520	6	.	.	PUNCT
ijpds-3133	521	1	2009	2009	NUM
ijpds-3133	521	2	;	;	PUNCT
ijpds-3133	521	3	66	66	NUM
ijpds-3133	521	4	:	:	PUNCT
ijpds-3133	521	5	2873–96	2873–96	NUM
ijpds-3133	521	6	.	.	PUNCT
ijpds-3133	522	1	62	62	NUM
ijpds-3133	522	2	.	.	PUNCT
ijpds-3133	523	1	chiang	chiang	PROPN
ijpds-3133	523	2	b	b	PROPN
ijpds-3133	523	3	,	,	PUNCT
ijpds-3133	523	4	kim	kim	PROPN
ijpds-3133	523	5	yc	yc	PROPN
ijpds-3133	523	6	,	,	PUNCT
ijpds-3133	523	7	doty	doty	NOUN
ijpds-3133	523	8	ac	ac	PROPN
ijpds-3133	523	9	,	,	PUNCT
ijpds-3133	523	10	et	et	PROPN
ijpds-3133	523	11	al	al	PROPN
ijpds-3133	523	12	.	.	PROPN
ijpds-3133	524	1	sustained	sustained	ADJ
ijpds-3133	524	2	reduction	reduction	NOUN
ijpds-3133	524	3	of	of	ADP
ijpds-3133	524	4	intraocular	intraocular	ADJ
ijpds-3133	524	5	pressure	pressure	NOUN
ijpds-3133	524	6	by	by	ADP
ijpds-3133	524	7	supraciliary	supraciliary	ADJ
ijpds-3133	524	8	delivery	delivery	NOUN
ijpds-3133	524	9	of	of	ADP
ijpds-3133	524	10	brimonidineloaded	brimonidineloaded	ADJ
ijpds-3133	524	11	poly	poly	ADJ
ijpds-3133	524	12	(	(	PUNCT
ijpds-3133	524	13	lactic	lactic	ADJ
ijpds-3133	524	14	acid	acid	NOUN
ijpds-3133	524	15	)	)	PUNCT
ijpds-3133	524	16	microspheres	microsphere	NOUN
ijpds-3133	524	17	for	for	ADP
ijpds-3133	524	18	the	the	DET
ijpds-3133	524	19	treatment	treatment	NOUN
ijpds-3133	524	20	of	of	ADP
ijpds-3133	524	21	glaucoma	glaucoma	NOUN
ijpds-3133	524	22	.	.	PUNCT
ijpds-3133	525	1	j	j	PROPN
ijpds-3133	525	2	control	control	PROPN
ijpds-3133	525	3	release	release	PROPN
ijpds-3133	525	4	2016	2016	NUM
ijpds-3133	525	5	;	;	PUNCT
ijpds-3133	525	6	228	228	NUM
ijpds-3133	525	7	:	:	PUNCT
ijpds-3133	526	1	48–57	48–57	NUM
ijpds-3133	526	2	.	.	NOUN
ijpds-3133	527	1	63	63	NUM
ijpds-3133	527	2	.	.	PUNCT
ijpds-3133	528	1	malavia	malavia	PROPN
ijpds-3133	528	2	n	n	CCONJ
ijpds-3133	528	3	,	,	PUNCT
ijpds-3133	528	4	reddy	reddy	PROPN
ijpds-3133	528	5	l	l	PROPN
ijpds-3133	528	6	,	,	PUNCT
ijpds-3133	528	7	szinai	szinai	PROPN
ijpds-3133	528	8	i	i	PROPN
ijpds-3133	528	9	,	,	PUNCT
ijpds-3133	528	10	et	et	PROPN
ijpds-3133	528	11	al	al	PROPN
ijpds-3133	528	12	.	.	PROPN
ijpds-3133	528	13	biodegradable	biodegradable	PROPN
ijpds-3133	528	14	sustainedrelease	sustainedrelease	PROPN
ijpds-3133	528	15	drug	drug	NOUN
ijpds-3133	528	16	delivery	delivery	NOUN
ijpds-3133	528	17	systems	system	NOUN
ijpds-3133	528	18	fabricated	fabricate	VERB
ijpds-3133	528	19	using	use	VERB
ijpds-3133	528	20	a	a	DET
ijpds-3133	528	21	dissolvable	dissolvable	ADJ
ijpds-3133	528	22	hydrogel	hydrogel	NOUN
ijpds-3133	528	23	template	template	NOUN
ijpds-3133	528	24	technology	technology	NOUN
ijpds-3133	528	25	for	for	ADP
ijpds-3133	528	26	the	the	DET
ijpds-3133	528	27	treatment	treatment	NOUN
ijpds-3133	528	28	of	of	ADP
ijpds-3133	528	29	ocular	ocular	ADJ
ijpds-3133	528	30	indications	indication	NOUN
ijpds-3133	528	31	.	.	PUNCT
ijpds-3133	529	1	invest	invest	VERB
ijpds-3133	529	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	529	3	vis	vis	X
ijpds-3133	529	4	sci	sci	PROPN
ijpds-3133	529	5	.	.	PROPN
ijpds-3133	529	6	2015	2015	NUM
ijpds-3133	529	7	;	;	PUNCT
ijpds-3133	529	8	56	56	NUM
ijpds-3133	529	9	:	:	SYM
ijpds-3133	529	10	1296	1296	NUM
ijpds-3133	529	11	.	.	PUNCT
ijpds-3133	530	1	64	64	NUM
ijpds-3133	530	2	.	.	PUNCT
ijpds-3133	530	3	fedorchak	fedorchak	PROPN
ijpds-3133	530	4	mv	mv	PROPN
ijpds-3133	530	5	,	,	PUNCT
ijpds-3133	530	6	conner	conner	PROPN
ijpds-3133	530	7	ip	ip	PROPN
ijpds-3133	530	8	,	,	PUNCT
ijpds-3133	530	9	schuman	schuman	PROPN
ijpds-3133	530	10	js	js	PROPN
ijpds-3133	530	11	,	,	PUNCT
ijpds-3133	530	12	et	et	PROPN
ijpds-3133	530	13	al	al	PROPN
ijpds-3133	530	14	.	.	PUNCT
ijpds-3133	530	15	long	long	ADJ
ijpds-3133	530	16	term	term	NOUN
ijpds-3133	530	17	glaucoma	glaucoma	NOUN
ijpds-3133	530	18	drug	drug	NOUN
ijpds-3133	530	19	delivery	delivery	NOUN
ijpds-3133	530	20	using	use	VERB
ijpds-3133	530	21	a	a	DET
ijpds-3133	530	22	topically	topically	ADV
ijpds-3133	530	23	retained	retain	VERB
ijpds-3133	530	24	gel	gel	NOUN
ijpds-3133	530	25	/	/	SYM
ijpds-3133	530	26	microsphere	microsphere	NOUN
ijpds-3133	530	27	eye	eye	NOUN
ijpds-3133	530	28	drop	drop	NOUN
ijpds-3133	530	29	.	.	PUNCT
ijpds-3133	531	1	sci	sci	PROPN
ijpds-3133	531	2	rep	rep	PROPN
ijpds-3133	531	3	.	.	PROPN
ijpds-3133	531	4	2017	2017	NUM
ijpds-3133	531	5	;	;	PUNCT
ijpds-3133	531	6	7	7	NUM
ijpds-3133	531	7	:	:	SYM
ijpds-3133	531	8	8639	8639	NUM
ijpds-3133	531	9	.	.	PUNCT
ijpds-3133	532	1	65	65	NUM
ijpds-3133	532	2	.	.	PUNCT
ijpds-3133	533	1	mansoor	mansoor	PROPN
ijpds-3133	533	2	s	s	PROPN
ijpds-3133	533	3	,	,	PUNCT
ijpds-3133	533	4	kuppermann	kuppermann	PROPN
ijpds-3133	533	5	bd	bd	PROPN
ijpds-3133	533	6	,	,	PUNCT
ijpds-3133	533	7	kenney	kenney	PROPN
ijpds-3133	533	8	mc	mc	PROPN
ijpds-3133	533	9	.	.	PROPN
ijpds-3133	533	10	intraocular	intraocular	PROPN
ijpds-3133	533	11	sustainedrelease	sustainedrelease	PROPN
ijpds-3133	533	12	delivery	delivery	NOUN
ijpds-3133	533	13	systems	system	NOUN
ijpds-3133	533	14	for	for	ADP
ijpds-3133	533	15	triamcinolone	triamcinolone	NOUN
ijpds-3133	533	16	acetonide	acetonide	NOUN
ijpds-3133	533	17	.	.	PUNCT
ijpds-3133	534	1	pharm	pharm	NOUN
ijpds-3133	534	2	res	re	NOUN
ijpds-3133	534	3	.	.	PUNCT
ijpds-3133	534	4	2009	2009	NUM
ijpds-3133	534	5	;	;	PUNCT
ijpds-3133	534	6	26	26	NUM
ijpds-3133	534	7	:	:	PUNCT
ijpds-3133	534	8	770–84	770–84	NOUN
ijpds-3133	534	9	.	.	PUNCT
ijpds-3133	535	1	66	66	NUM
ijpds-3133	535	2	.	.	PUNCT
ijpds-3133	536	1	okabe	okabe	PROPN
ijpds-3133	536	2	k	k	PROPN
ijpds-3133	536	3	,	,	PUNCT
ijpds-3133	536	4	kimura	kimura	NOUN
ijpds-3133	536	5	h	h	NOUN
ijpds-3133	536	6	,	,	PUNCT
ijpds-3133	536	7	okabe	okabe	PROPN
ijpds-3133	536	8	j	j	PROPN
ijpds-3133	536	9	,	,	PUNCT
ijpds-3133	536	10	et	et	PROPN
ijpds-3133	536	11	al	al	PROPN
ijpds-3133	536	12	.	.	PUNCT
ijpds-3133	537	1	intraocular	intraocular	ADJ
ijpds-3133	537	2	tissue	tissue	NOUN
ijpds-3133	537	3	distribution	distribution	NOUN
ijpds-3133	537	4	of	of	ADP
ijpds-3133	537	5	betamethasone	betamethasone	NOUN
ijpds-3133	537	6	after	after	SCONJ
ijpds-3133	537	7	intrascleral	intrascleral	PROPN
ijpds-3133	537	8	administration	administration	NOUN
ijpds-3133	537	9	using	use	VERB
ijpds-3133	537	10	a	a	DET
ijpds-3133	537	11	non	non	ADJ
ijpds-3133	537	12	-	-	ADJ
ijpds-3133	537	13	biodegradable	biodegradable	ADJ
ijpds-3133	537	14	sustained	sustained	ADJ
ijpds-3133	537	15	drug	drug	NOUN
ijpds-3133	537	16	delivery	delivery	NOUN
ijpds-3133	537	17	device	device	NOUN
ijpds-3133	537	18	.	.	PUNCT
ijpds-3133	538	1	invest	invest	VERB
ijpds-3133	538	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	538	3	vis	vis	X
ijpds-3133	538	4	sci	sci	PROPN
ijpds-3133	538	5	.	.	PROPN
ijpds-3133	538	6	2003	2003	NUM
ijpds-3133	538	7	;	;	PUNCT
ijpds-3133	538	8	44	44	NUM
ijpds-3133	538	9	:	:	PUNCT
ijpds-3133	538	10	2702–07	2702–07	NUM
ijpds-3133	538	11	.	.	PUNCT
ijpds-3133	539	1	67	67	NUM
ijpds-3133	539	2	.	.	PUNCT
ijpds-3133	540	1	bao	bao	PROPN
ijpds-3133	540	2	w	w	PROPN
ijpds-3133	540	3	,	,	PUNCT
ijpds-3133	540	4	zhou	zhou	PROPN
ijpds-3133	540	5	j	j	PROPN
ijpds-3133	540	6	,	,	PUNCT
ijpds-3133	540	7	luo	luo	PROPN
ijpds-3133	540	8	j	j	PROPN
ijpds-3133	540	9	,	,	PUNCT
ijpds-3133	540	10	et	et	PROPN
ijpds-3133	540	11	al	al	PROPN
ijpds-3133	540	12	.	.	PROPN
ijpds-3133	540	13	plga	plga	PROPN
ijpds-3133	540	14	microspheres	microsphere	NOUN
ijpds-3133	540	15	with	with	ADP
ijpds-3133	540	16	high	high	ADJ
ijpds-3133	540	17	drug	drug	NOUN
ijpds-3133	540	18	loading	loading	NOUN
ijpds-3133	540	19	and	and	CCONJ
ijpds-3133	540	20	high	high	ADJ
ijpds-3133	540	21	encapsulation	encapsulation	NOUN
ijpds-3133	540	22	efficiency	efficiency	NOUN
ijpds-3133	540	23	prepared	prepare	VERB
ijpds-3133	540	24	by	by	ADP
ijpds-3133	540	25	a	a	DET
ijpds-3133	540	26	novel	novel	ADJ
ijpds-3133	540	27	solvent	solvent	NOUN
ijpds-3133	540	28	evaporation	evaporation	NOUN
ijpds-3133	540	29	technique	technique	NOUN
ijpds-3133	540	30	.	.	PUNCT
ijpds-3133	541	1	j	j	PROPN
ijpds-3133	541	2	micro	micro	PROPN
ijpds-3133	541	3	encapsule	encapsule	PROPN
ijpds-3133	541	4	.	.	PUNCT
ijpds-3133	542	1	2006	2006	NUM
ijpds-3133	542	2	;	;	PUNCT
ijpds-3133	542	3	23:471	23:471	NUM
ijpds-3133	542	4	-	-	SYM
ijpds-3133	542	5	79	79	NUM
ijpds-3133	542	6	.	.	PUNCT
ijpds-3133	543	1	68	68	NUM
ijpds-3133	543	2	.	.	PUNCT
ijpds-3133	544	1	clinicaltrials.gov	clinicaltrials.gov	X
ijpds-3133	544	2	.	.	NOUN
ijpds-3133	544	3	safety	safety	NOUN
ijpds-3133	544	4	and	and	CCONJ
ijpds-3133	544	5	efficacy	efficacy	NOUN
ijpds-3133	544	6	of	of	ADP
ijpds-3133	544	7	env515	env515	NOUN
ijpds-3133	544	8	travoprost	travoprost	VERB
ijpds-3133	544	9	extended	extend	VERB
ijpds-3133	544	10	release	release	NOUN
ijpds-3133	544	11	(	(	PUNCT
ijpds-3133	544	12	xr	xr	X
ijpds-3133	544	13	)	)	PUNCT
ijpds-3133	544	14	in	in	ADP
ijpds-3133	544	15	patients	patient	NOUN
ijpds-3133	544	16	with	with	ADP
ijpds-3133	544	17	bilateral	bilateral	ADJ
ijpds-3133	544	18	ocular	ocular	ADJ
ijpds-3133	544	19	hypertension	hypertension	NOUN
ijpds-3133	544	20	or	or	CCONJ
ijpds-3133	544	21	primary	primary	ADJ
ijpds-3133	544	22	open	open	ADJ
ijpds-3133	544	23	angle	angle	NOUN
ijpds-3133	544	24	glaucoma	glaucoma	NOUN
ijpds-3133	544	25	.	.	PUNCT
ijpds-3133	545	1	2019	2019	NUM
ijpds-3133	545	2	;	;	PUNCT
ijpds-3133	545	3	https://clinicaltrials.gov/ct2/show/nct02371746	https://clinicaltrials.gov/ct2/show/nct02371746	PROPN
ijpds-3133	545	4	.	.	PUNCT
ijpds-3133	546	1	69	69	NUM
ijpds-3133	546	2	.	.	PUNCT
ijpds-3133	547	1	allergan	allergan	PROPN
ijpds-3133	547	2	announces	announce	VERB
ijpds-3133	547	3	positive	positive	ADJ
ijpds-3133	547	4	topline	topline	NOUN
ijpds-3133	547	5	phase	phase	NOUN
ijpds-3133	547	6	3	3	NUM
ijpds-3133	547	7	clinical	clinical	ADJ
ijpds-3133	547	8	data	datum	NOUN
ijpds-3133	547	9	for	for	ADP
ijpds-3133	547	10	bimatoprost	bimatoprost	NOUN
ijpds-3133	547	11	sr	sr	PROPN
ijpds-3133	547	12	(	(	PUNCT
ijpds-3133	547	13	sustained	sustain	VERB
ijpds-3133	547	14	-	-	PUNCT
ijpds-3133	547	15	release	release	NOUN
ijpds-3133	547	16	)	)	PUNCT
ijpds-3133	547	17	implant	implant	NOUN
ijpds-3133	547	18	for	for	ADP
ijpds-3133	547	19	iop	iop	NOUN
ijpds-3133	547	20	lowering	lower	VERB
ijpds-3133	547	21	in	in	ADP
ijpds-3133	547	22	patients	patient	NOUN
ijpds-3133	547	23	with	with	ADP
ijpds-3133	547	24	open	open	ADJ
ijpds-3133	547	25	-	-	PUNCT
ijpds-3133	547	26	angle	angle	NOUN
ijpds-3133	547	27	glaucoma	glaucoma	NOUN
ijpds-3133	547	28	or	or	CCONJ
ijpds-3133	547	29	ocular	ocular	ADJ
ijpds-3133	547	30	hypertension	hypertension	NOUN
ijpds-3133	547	31	.	.	PUNCT
ijpds-3133	548	1	70	70	X
ijpds-3133	548	2	.	.	PUNCT
ijpds-3133	549	1	gb—201	gb—201	NOUN
ijpds-3133	549	2	,	,	PUNCT
ijpds-3133	549	3	gb—202	gb—202	PROPN
ijpds-3133	549	4	,	,	PUNCT
ijpds-3133	549	5	and	and	CCONJ
ijpds-3133	549	6	gb—203	gb—203	NOUN
ijpds-3133	549	7	—	—	PUNCT
ijpds-3133	549	8	glaucoma	glaucoma	NOUN
ijpds-3133	549	9	products	product	NOUN
ijpds-3133	549	10	.	.	PUNCT
ijpds-3133	550	1	graybug	graybug	ADJ
ijpds-3133	550	2	vision	vision	NOUN
ijpds-3133	550	3	.	.	PUNCT
ijpds-3133	551	1	71	71	NUM
ijpds-3133	551	2	.	.	PUNCT
ijpds-3133	551	3	hoang	hoang	PROPN
ijpds-3133	551	4	bp	bp	PROPN
ijpds-3133	551	5	,	,	PUNCT
ijpds-3133	551	6	crean	crean	PROPN
ijpds-3133	551	7	cs	cs	PROPN
ijpds-3133	551	8	,	,	PUNCT
ijpds-3133	551	9	yang	yang	PROPN
ijpds-3133	551	10	ml	ml	PROPN
ijpds-3133	551	11	,	,	PUNCT
ijpds-3133	551	12	et	et	PROPN
ijpds-3133	551	13	al	al	PROPN
ijpds-3133	551	14	.	.	PUNCT
ijpds-3133	552	1	an	an	DET
ijpds-3133	552	2	injectable	injectable	ADJ
ijpds-3133	552	3	depot	depot	NOUN
ijpds-3133	552	4	formulation	formulation	NOUN
ijpds-3133	552	5	of	of	ADP
ijpds-3133	552	6	an	an	DET
ijpds-3133	552	7	outflow	outflow	ADJ
ijpds-3133	552	8	prodrug	prodrug	NOUN
ijpds-3133	552	9	for	for	ADP
ijpds-3133	552	10	sustained	sustained	ADJ
ijpds-3133	552	11	reduction	reduction	NOUN
ijpds-3133	552	12	of	of	ADP
ijpds-3133	552	13	intraocular	intraocular	ADJ
ijpds-3133	552	14	pressure	pressure	NOUN
ijpds-3133	552	15	.	.	PUNCT
ijpds-3133	553	1	invest	invest	VERB
ijpds-3133	553	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	553	3	vis	vis	X
ijpds-3133	553	4	sci	sci	PROPN
ijpds-3133	553	5	.	.	PROPN
ijpds-3133	553	6	2018	2018	NUM
ijpds-3133	553	7	;	;	PUNCT
ijpds-3133	553	8	59	59	NUM
ijpds-3133	553	9	:	:	PUNCT
ijpds-3133	553	10	5710	5710	NUM
ijpds-3133	553	11	.	.	PUNCT
ijpds-3133	554	1	72	72	NUM
ijpds-3133	554	2	.	.	PUNCT
ijpds-3133	555	1	gebhart	gebhart	PROPN
ijpds-3133	555	2	f.	f.	PROPN
ijpds-3133	555	3	drug	drug	PROPN
ijpds-3133	555	4	-	-	PUNCT
ijpds-3133	555	5	delivery	delivery	NOUN
ijpds-3133	555	6	platforms	platform	NOUN
ijpds-3133	555	7	offer	offer	VERB
ijpds-3133	555	8	more	more	ADJ
ijpds-3133	555	9	options	option	NOUN
ijpds-3133	555	10	and	and	CCONJ
ijpds-3133	555	11	promise	promise	NOUN
ijpds-3133	555	12	for	for	ADP
ijpds-3133	555	13	clinicians	clinician	NOUN
ijpds-3133	555	14	.	.	PUNCT
ijpds-3133	556	1	ophthalmol	ophthalmol	PROPN
ijpds-3133	556	2	times	time	NOUN
ijpds-3133	556	3	.	.	PUNCT
ijpds-3133	557	1	2017	2017	NUM
ijpds-3133	557	2	;	;	PUNCT
ijpds-3133	557	3	2:35	2:35	NUM
ijpds-3133	557	4	-	-	SYM
ijpds-3133	557	5	42	42	NUM
ijpds-3133	557	6	.	.	PUNCT
ijpds-3133	558	1	73	73	NUM
ijpds-3133	558	2	.	.	PUNCT
ijpds-3133	559	1	perera	perera	PROPN
ijpds-3133	559	2	sa	sa	PROPN
ijpds-3133	559	3	,	,	PUNCT
ijpds-3133	559	4	ting	ting	PROPN
ijpds-3133	559	5	dsw	dsw	PROPN
ijpds-3133	559	6	,	,	PUNCT
ijpds-3133	559	7	nongpiur	nongpiur	VERB
ijpds-3133	559	8	me	i	PRON
ijpds-3133	559	9	,	,	PUNCT
ijpds-3133	559	10	et	et	PROPN
ijpds-3133	559	11	al	al	PROPN
ijpds-3133	559	12	.	.	PUNCT
ijpds-3133	560	1	feasibility	feasibility	NOUN
ijpds-3133	560	2	study	study	NOUN
ijpds-3133	560	3	of	of	ADP
ijpds-3133	560	4	sustained	sustain	VERB
ijpds-3133	560	5	-	-	PUNCT
ijpds-3133	560	6	release	release	NOUN
ijpds-3133	560	7	travoprost	travoprost	VERB
ijpds-3133	560	8	punctum	punctum	NOUN
ijpds-3133	560	9	plug	plug	NOUN
ijpds-3133	560	10	for	for	ADP
ijpds-3133	560	11	intraocular	intraocular	ADJ
ijpds-3133	560	12	pressure	pressure	NOUN
ijpds-3133	560	13	reduction	reduction	NOUN
ijpds-3133	560	14	in	in	ADP
ijpds-3133	560	15	an	an	DET
ijpds-3133	560	16	asian	asian	ADJ
ijpds-3133	560	17	population	population	NOUN
ijpds-3133	560	18	.	.	PUNCT
ijpds-3133	561	1	clin	clin	PROPN
ijpds-3133	561	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	561	3	.	.	PUNCT
ijpds-3133	562	1	2016	2016	NUM
ijpds-3133	562	2	;	;	PUNCT
ijpds-3133	562	3	10	10	NUM
ijpds-3133	562	4	:	:	PUNCT
ijpds-3133	562	5	757–64	757–64	NUM
ijpds-3133	562	6	.	.	NOUN
ijpds-3133	563	1	74	74	NUM
ijpds-3133	563	2	.	.	PUNCT
ijpds-3133	564	1	goldberg	goldberg	PROPN
ijpds-3133	564	2	df	df	PROPN
ijpds-3133	564	3	,	,	PUNCT
ijpds-3133	564	4	williams	williams	PROPN
ijpds-3133	564	5	r.a	r.a	PROPN
ijpds-3133	564	6	.	.	PROPN
ijpds-3133	564	7	phase	phase	NOUN
ijpds-3133	564	8	2	2	NUM
ijpds-3133	564	9	study	study	NOUN
ijpds-3133	564	10	evaluating	evaluate	VERB
ijpds-3133	564	11	safety	safety	NOUN
ijpds-3133	564	12	and	and	CCONJ
ijpds-3133	564	13	efficacy	efficacy	NOUN
ijpds-3133	564	14	of	of	ADP
ijpds-3133	564	15	the	the	DET
ijpds-3133	564	16	latanoprost	latanoprost	VERB
ijpds-3133	564	17	punctal	punctal	ADJ
ijpds-3133	564	18	plug	plug	NOUN
ijpds-3133	564	19	delivery	delivery	NOUN
ijpds-3133	564	20	system	system	NOUN
ijpds-3133	564	21	(	(	PUNCT
ijpds-3133	564	22	lppds	lppds	PROPN
ijpds-3133	564	23	)	)	PUNCT
ijpds-3133	564	24	in	in	ADP
ijpds-3133	564	25	subjects	subject	NOUN
ijpds-3133	564	26	with	with	ADP
ijpds-3133	564	27	ocular	ocular	ADJ
ijpds-3133	564	28	hypertension	hypertension	NOUN
ijpds-3133	564	29	(	(	PUNCT
ijpds-3133	564	30	oh	oh	INTJ
ijpds-3133	564	31	)	)	PUNCT
ijpds-3133	564	32	or	or	CCONJ
ijpds-3133	564	33	openangle	openangle	VERB
ijpds-3133	564	34	glaucoma	glaucoma	NOUN
ijpds-3133	564	35	(	(	PUNCT
ijpds-3133	564	36	oag	oag	PROPN
ijpds-3133	564	37	)	)	PUNCT
ijpds-3133	564	38	.	.	PUNCT
ijpds-3133	565	1	iovs	iovs	PROPN
ijpds-3133	565	2	arvo	arvo	PROPN
ijpds-3133	565	3	journals	journal	NOUN
ijpds-3133	565	4	.	.	PUNCT
ijpds-3133	566	1	2019	2019	NUM
ijpds-3133	566	2	;	;	PUNCT
ijpds-3133	566	3	22:13448	22:13448	X
ijpds-3133	566	4	.	.	X
ijpds-3133	567	1	75	75	NUM
ijpds-3133	567	2	.	.	PUNCT
ijpds-3133	568	1	utkhede	utkhede	ADJ
ijpds-3133	568	2	d	d	PROPN
ijpds-3133	568	3	,	,	PUNCT
ijpds-3133	568	4	william	william	PROPN
ijpds-3133	568	5	r.	r.	PROPN
ijpds-3133	568	6	improving	improve	VERB
ijpds-3133	568	7	retention	retention	NOUN
ijpds-3133	568	8	rates	rate	NOUN
ijpds-3133	568	9	for	for	ADP
ijpds-3133	568	10	sustained	sustain	VERB
ijpds-3133	568	11	therapeutic	therapeutic	ADJ
ijpds-3133	568	12	delivery	delivery	NOUN
ijpds-3133	568	13	through	through	ADP
ijpds-3133	568	14	punctal	punctal	ADJ
ijpds-3133	568	15	plugs	plug	NOUN
ijpds-3133	568	16	.	.	PUNCT
ijpds-3133	569	1	invest	invest	VERB
ijpds-3133	569	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	569	3	vis	vis	X
ijpds-3133	569	4	sci	sci	PROPN
ijpds-3133	569	5	.	.	PROPN
ijpds-3133	569	6	2018	2018	NUM
ijpds-3133	569	7	;	;	PUNCT
ijpds-3133	569	8	59	59	NUM
ijpds-3133	569	9	:	:	SYM
ijpds-3133	569	10	5675	5675	NUM
ijpds-3133	569	11	.	.	PUNCT
ijpds-3133	570	1	76	76	NUM
ijpds-3133	570	2	.	.	PUNCT
ijpds-3133	571	1	patel	patel	PROPN
ijpds-3133	571	2	sp	sp	PROPN
ijpds-3133	571	3	,	,	PUNCT
ijpds-3133	571	4	vaishya	vaishya	PROPN
ijpds-3133	571	5	r	r	NOUN
ijpds-3133	571	6	,	,	PUNCT
ijpds-3133	571	7	pal	pal	NOUN
ijpds-3133	571	8	d	d	NOUN
ijpds-3133	571	9	,	,	PUNCT
ijpds-3133	571	10	et	et	PROPN
ijpds-3133	571	11	al	al	PROPN
ijpds-3133	571	12	.	.	PROPN
ijpds-3133	571	13	novel	novel	PROPN
ijpds-3133	571	14	pentablock	pentablock	NOUN
ijpds-3133	571	15	copolymerbased	copolymerbase	VERB
ijpds-3133	571	16	nanoparticulate	nanoparticulate	ADJ
ijpds-3133	571	17	systems	system	NOUN
ijpds-3133	571	18	for	for	ADP
ijpds-3133	571	19	sustained	sustained	ADJ
ijpds-3133	571	20	protein	protein	NOUN
ijpds-3133	571	21	delivery	delivery	NOUN
ijpds-3133	571	22	.	.	PUNCT
ijpds-3133	572	1	aaps	aap	NOUN
ijpds-3133	572	2	pharm	pharm	VERB
ijpds-3133	572	3	sci	sci	PROPN
ijpds-3133	572	4	tech	tech	NOUN
ijpds-3133	572	5	.	.	PUNCT
ijpds-3133	573	1	2015;16	2015;16	NUM
ijpds-3133	573	2	:	:	PUNCT
ijpds-3133	574	1	327–43	327–43	NUM
ijpds-3133	574	2	.	.	PUNCT
ijpds-3133	575	1	77	77	NUM
ijpds-3133	575	2	.	.	PUNCT
ijpds-3133	575	3	shafiee	shafiee	PROPN
ijpds-3133	575	4	a	a	PRON
ijpds-3133	575	5	,	,	PUNCT
ijpds-3133	575	6	bowman	bowman	PROPN
ijpds-3133	575	7	lm	lm	PROPN
ijpds-3133	575	8	,	,	PUNCT
ijpds-3133	575	9	hou	hou	PROPN
ijpds-3133	575	10	e	e	PROPN
ijpds-3133	575	11	,	,	PUNCT
ijpds-3133	575	12	et	et	PROPN
ijpds-3133	575	13	al	al	PROPN
ijpds-3133	575	14	.	.	PROPN
ijpds-3133	576	1	ocular	ocular	ADJ
ijpds-3133	576	2	pharmacokinetics	pharmacokinetic	NOUN
ijpds-3133	576	3	of	of	ADP
ijpds-3133	576	4	bimatoprost	bimatoprost	NOUN
ijpds-3133	576	5	formulated	formulate	VERB
ijpds-3133	576	6	in	in	ADP
ijpds-3133	576	7	durasite	durasite	NOUN
ijpds-3133	576	8	compared	compare	VERB
ijpds-3133	576	9	to	to	ADP
ijpds-3133	576	10	bimatoprost	bimatoprost	NOUN
ijpds-3133	576	11	0.03	0.03	NUM
ijpds-3133	576	12	%	%	NOUN
ijpds-3133	576	13	ophthalmic	ophthalmic	ADJ
ijpds-3133	576	14	solution	solution	NOUN
ijpds-3133	576	15	in	in	ADP
ijpds-3133	576	16	pigmented	pigmented	ADJ
ijpds-3133	576	17	rabbit	rabbit	NOUN
ijpds-3133	576	18	eyes	eye	NOUN
ijpds-3133	576	19	.	.	PUNCT
ijpds-3133	577	1	clin	clin	PROPN
ijpds-3133	577	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	577	3	.	.	PUNCT
ijpds-3133	578	1	2013;7:1549	2013;7:1549	NUM
ijpds-3133	578	2	-	-	SYM
ijpds-3133	578	3	56	56	NUM
ijpds-3133	578	4	.	.	PUNCT
ijpds-3133	579	1	78	78	NUM
ijpds-3133	579	2	.	.	PUNCT
ijpds-3133	580	1	jiang	jiang	PROPN
ijpds-3133	580	2	j	j	PROPN
ijpds-3133	580	3	,	,	PUNCT
ijpds-3133	580	4	gill	gill	PROPN
ijpds-3133	580	5	hs	hs	PROPN
ijpds-3133	580	6	,	,	PUNCT
ijpds-3133	580	7	ghate	ghate	NOUN
ijpds-3133	580	8	d	d	NOUN
ijpds-3133	580	9	,	,	PUNCT
ijpds-3133	580	10	et	et	PROPN
ijpds-3133	580	11	al	al	PROPN
ijpds-3133	580	12	.	.	PUNCT
ijpds-3133	581	1	coated	coated	ADJ
ijpds-3133	581	2	microneedles	microneedle	NOUN
ijpds-3133	581	3	for	for	ADP
ijpds-3133	581	4	drug	drug	NOUN
ijpds-3133	581	5	delivery	delivery	NOUN
ijpds-3133	581	6	to	to	ADP
ijpds-3133	581	7	the	the	DET
ijpds-3133	581	8	eye	eye	NOUN
ijpds-3133	581	9	.	.	PUNCT
ijpds-3133	582	1	invest	invest	VERB
ijpds-3133	582	2	ophthalmol	ophthalmol	PROPN
ijpds-3133	582	3	vis	vis	X
ijpds-3133	582	4	sci	sci	PROPN
ijpds-3133	582	5	.	.	PROPN
ijpds-3133	582	6	2007	2007	NUM
ijpds-3133	582	7	;	;	PUNCT
ijpds-3133	582	8	48	48	NUM
ijpds-3133	582	9	:	:	SYM
ijpds-3133	582	10	4038	4038	NUM
ijpds-3133	582	11	–	–	PUNCT
ijpds-3133	582	12	43	43	NUM
ijpds-3133	582	13	.	.	PUNCT
ijpds-3133	583	1	how	how	SCONJ
ijpds-3133	583	2	to	to	PART
ijpds-3133	583	3	cite	cite	VERB
ijpds-3133	583	4	this	this	DET
ijpds-3133	583	5	article	article	NOUN
ijpds-3133	583	6	:	:	PUNCT
ijpds-3133	583	7	rai	rai	PROPN
ijpds-3133	583	8	a	a	X
ijpds-3133	583	9	,	,	PUNCT
ijpds-3133	583	10	castro	castro	VERB
ijpds-3133	583	11	a	a	PRON
ijpds-3133	583	12	,	,	PUNCT
ijpds-3133	583	13	brar	brar	PROPN
ijpds-3133	583	14	j	j	PROPN
ijpds-3133	583	15	,	,	PUNCT
ijpds-3133	583	16	smith	smith	PROPN
ijpds-3133	583	17	cr	cr	PROPN
ijpds-3133	583	18	.	.	PUNCT
ijpds-3133	583	19	impact	impact	NOUN
ijpds-3133	583	20	of	of	ADP
ijpds-3133	583	21	mindfulness	mindfulness	NOUN
ijpds-3133	583	22	-	-	PUNCT
ijpds-3133	583	23	based	base	VERB
ijpds-3133	583	24	stress	stress	NOUN
ijpds-3133	583	25	reduction	reduction	NOUN
ijpds-3133	583	26	techniques	technique	NOUN
ijpds-3133	583	27	on	on	ADP
ijpds-3133	583	28	general	general	ADJ
ijpds-3133	583	29	well	well	NOUN
ijpds-3133	583	30	-	-	PUNCT
ijpds-3133	583	31	being	being	NOUN
ijpds-3133	583	32	of	of	ADP
ijpds-3133	583	33	employees	employee	NOUN
ijpds-3133	583	34	working	work	VERB
ijpds-3133	583	35	on	on	ADP
ijpds-3133	583	36	a	a	DET
ijpds-3133	583	37	behavioral	behavioral	ADJ
ijpds-3133	583	38	health	health	NOUN
ijpds-3133	583	39	unit	unit	NOUN
ijpds-3133	583	40	.	.	PUNCT
ijpds-3133	584	1	indian	indian	PROPN
ijpds-3133	584	2	j	j	PROPN
ijpds-3133	584	3	pharm	pharm	PROPN
ijpds-3133	584	4	drug	drug	PROPN
ijpds-3133	584	5	studies	study	NOUN
ijpds-3133	584	6	.	.	PUNCT
ijpds-3133	584	7	2022	2022	NUM
ijpds-3133	584	8	;	;	PUNCT
ijpds-3133	584	9	1(2	1(2	NUM
ijpds-3133	584	10	):	):	PUNCT
ijpds-3133	584	11	38	38	NUM
ijpds-3133	584	12	-	-	SYM
ijpds-3133	584	13	46	46	NUM
ijpds-3133	584	14	.	.	PUNCT
ijpds-3133	585	1	funding	funding	NOUN
ijpds-3133	585	2	:	:	PUNCT
ijpds-3133	585	3	none	none	NOUN
ijpds-3133	585	4	conflict	conflict	NOUN
ijpds-3133	585	5	of	of	ADP
ijpds-3133	585	6	interest	interest	NOUN
ijpds-3133	585	7	:	:	PUNCT
ijpds-3133	585	8	none	none	NOUN
ijpds-3133	585	9	stated	state	VERB
ijpds-3133	585	10	https://clinicaltrials.gov/ct2/show/nct02371746	https://clinicaltrials.gov/ct2/show/nct02371746	PROPN
ijpds-3133	585	11	.	.	PUNCT