id	sid	tid	token	lemma	pos
ijpds-3217	1	1	soares	soar	VERB
ijpds-3217	1	2	et	et	PROPN
ijpds-3217	1	3	al	al	PROPN
ijpds-3217	1	4	hsa	hsa	PROPN
ijpds-3217	1	5	-	-	PUNCT
ijpds-3217	1	6	hctz	hctz	ADJ
ijpds-3217	1	7	interactions	interaction	NOUN
ijpds-3217	1	8	based	base	VERB
ijpds-3217	1	9	on	on	ADP
ijpds-3217	1	10	glucose	glucose	NOUN
ijpds-3217	1	11	concentrations	concentration	NOUN
ijpds-3217	1	12	vol	vol	NOUN
ijpds-3217	1	13	1	1	NUM
ijpds-3217	1	14	|	|	NOUN
ijpds-3217	1	15	issue	issue	NOUN
ijpds-3217	1	16	2	2	NUM
ijpds-3217	2	1	|	|	ADV
ijpds-3217	2	2	jul	jul	PROPN
ijpds-3217	2	3	sep	sep	PROPN
ijpds-3217	2	4	2022	2022	NUM
ijpds-3217	2	5	indian	indian	PROPN
ijpds-3217	2	6	j	j	PROPN
ijpds-3217	2	7	pharm	pharm	PROPN
ijpds-3217	2	8	drug	drug	PROPN
ijpds-3217	2	9	studies	study	NOUN
ijpds-3217	2	10	|	|	ADV
ijpds-3217	2	11	56	56	NUM
ijpds-3217	2	12	original	original	ADJ
ijpds-3217	2	13	article	article	NOUN
ijpds-3217	2	14	effect	effect	NOUN
ijpds-3217	2	15	of	of	ADP
ijpds-3217	2	16	glucose	glucose	NOUN
ijpds-3217	2	17	concentrations	concentration	NOUN
ijpds-3217	2	18	on	on	ADP
ijpds-3217	2	19	the	the	DET
ijpds-3217	2	20	hsa	hsa	PROPN
ijpds-3217	2	21	-	-	PUNCT
ijpds-3217	2	22	hydrochlorothiazide	hydrochlorothiazide	NOUN
ijpds-3217	2	23	interaction	interaction	NOUN
ijpds-3217	2	24	–	–	PUNCT
ijpds-3217	2	25	a	a	DET
ijpds-3217	2	26	study	study	NOUN
ijpds-3217	2	27	using	use	VERB
ijpds-3217	2	28	circular	circular	ADJ
ijpds-3217	2	29	dichroism	dichroism	NOUN
ijpds-3217	2	30	and	and	CCONJ
ijpds-3217	2	31	molecular	molecular	ADJ
ijpds-3217	2	32	docking	docking	NOUN
ijpds-3217	2	33	marilia	marilia	PROPN
ijpds-3217	2	34	amável	amável	PROPN
ijpds-3217	2	35	gomes	gome	NOUN
ijpds-3217	2	36	soares1	soares1	PROPN
ijpds-3217	2	37	,	,	PUNCT
ijpds-3217	2	38	otávio	otávio	NOUN
ijpds-3217	2	39	augusto	augusto	PROPN
ijpds-3217	2	40	chaves	chave	NOUN
ijpds-3217	2	41	2	2	NUM
ijpds-3217	2	42	,	,	PUNCT
ijpds-3217	2	43	antônio	antônio	NOUN
ijpds-3217	2	44	augusto	augusto	PROPN
ijpds-3217	2	45	fidalgo	fidalgo	PROPN
ijpds-3217	2	46	neto2	neto2	PROPN
ijpds-3217	2	47	,	,	PUNCT
ijpds-3217	2	48	dilson	dilson	NOUN
ijpds-3217	2	49	silva1	silva1	PROPN
ijpds-3217	2	50	,	,	PUNCT
ijpds-3217	2	51	dari	dari	PROPN
ijpds-3217	2	52	cesarin	cesarin	PROPN
ijpds-3217	2	53	-	-	PUNCT
ijpds-3217	2	54	sobrinho3	sobrinho3	PROPN
ijpds-3217	2	55	,	,	PUNCT
ijpds-3217	2	56	célia	célia	PROPN
ijpds-3217	2	57	martins	martin	NOUN
ijpds-3217	2	58	cortez1	cortez1	PROPN
ijpds-3217	3	1	from,1postgraduation	from,1postgraduation	NOUN
ijpds-3217	3	2	in	in	ADP
ijpds-3217	3	3	medical	medical	ADJ
ijpds-3217	3	4	sciences	sciences	PROPN
ijpds-3217	3	5	,	,	PUNCT
ijpds-3217	3	6	rio	rio	PROPN
ijpds-3217	3	7	de	de	PROPN
ijpds-3217	3	8	janeiro	janeiro	PROPN
ijpds-3217	3	9	state	state	PROPN
ijpds-3217	3	10	university	university	PROPN
ijpds-3217	3	11	,	,	PUNCT
ijpds-3217	3	12	brazil	brazil	PROPN
ijpds-3217	3	13	,	,	PUNCT
ijpds-3217	3	14	2institute	2institute	NUM
ijpds-3217	3	15	of	of	ADP
ijpds-3217	3	16	chemistry	chemistry	NOUN
ijpds-3217	3	17	,	,	PUNCT
ijpds-3217	3	18	federal	federal	ADJ
ijpds-3217	3	19	rural	rural	ADJ
ijpds-3217	3	20	university	university	PROPN
ijpds-3217	3	21	of	of	ADP
ijpds-3217	3	22	rio	rio	PROPN
ijpds-3217	3	23	de	de	PROPN
ijpds-3217	3	24	janeiro	janeiro	PROPN
ijpds-3217	3	25	correspondence	correspondence	NOUN
ijpds-3217	3	26	to	to	ADP
ijpds-3217	3	27	:	:	PUNCT
ijpds-3217	3	28	celia	celia	PROPN
ijpds-3217	3	29	martins	martins	PROPN
ijpds-3217	3	30	cortez	cortez	PROPN
ijpds-3217	3	31	,	,	PUNCT
ijpds-3217	3	32	rio	rio	PROPN
ijpds-3217	3	33	de	de	PROPN
ijpds-3217	3	34	janeiro	janeiro	PROPN
ijpds-3217	3	35	state	state	PROPN
ijpds-3217	3	36	university	university	PROPN
ijpds-3217	3	37	,	,	PUNCT
ijpds-3217	3	38	postgraduation	postgraduation	NOUN
ijpds-3217	3	39	in	in	ADP
ijpds-3217	3	40	medical	medical	ADJ
ijpds-3217	3	41	sciences	science	NOUN
ijpds-3217	3	42	,	,	PUNCT
ijpds-3217	3	43	av	av	PROPN
ijpds-3217	3	44	.	.	PROPN
ijpds-3217	3	45	prof	prof	PROPN
ijpds-3217	3	46	.	.	PUNCT
ijpds-3217	4	1	manuel	manuel	PROPN
ijpds-3217	4	2	de	de	PROPN
ijpds-3217	4	3	abreu	abreu	PROPN
ijpds-3217	4	4	,	,	PUNCT
ijpds-3217	4	5	444	444	NUM
ijpds-3217	4	6	.	.	PUNCT
ijpds-3217	5	1	cep	cep	ADV
ijpds-3217	5	2	20551	20551	NUM
ijpds-3217	5	3	-	-	SYM
ijpds-3217	5	4	170	170	NUM
ijpds-3217	5	5	rio	rio	PROPN
ijpds-3217	5	6	de	de	PROPN
ijpds-3217	5	7	janeiro	janeiro	PROPN
ijpds-3217	5	8	,	,	PUNCT
ijpds-3217	5	9	rj	rj	PROPN
ijpds-3217	5	10	brazil	brazil	PROPN
ijpds-3217	5	11	.	.	PUNCT
ijpds-3217	6	1	email	email	NOUN
ijpds-3217	6	2	:	:	PUNCT
ijpds-3217	6	3	ccortezs@ime.uerj.br	ccortezs@ime.uerj.br	ADJ
ijpds-3217	6	4	abstract	abstract	ADJ
ijpds-3217	6	5	diabetes	diabetes	NOUN
ijpds-3217	6	6	mellitus	mellitus	NOUN
ijpds-3217	6	7	is	be	AUX
ijpds-3217	6	8	a	a	DET
ijpds-3217	6	9	chronic	chronic	ADJ
ijpds-3217	6	10	disease	disease	NOUN
ijpds-3217	6	11	characterized	characterize	VERB
ijpds-3217	6	12	by	by	ADP
ijpds-3217	6	13	hyperglycemia	hyperglycemia	NOUN
ijpds-3217	6	14	and	and	CCONJ
ijpds-3217	6	15	is	be	AUX
ijpds-3217	6	16	accompanied	accompany	VERB
ijpds-3217	6	17	by	by	ADP
ijpds-3217	6	18	disturbances	disturbance	NOUN
ijpds-3217	6	19	in	in	ADP
ijpds-3217	6	20	the	the	DET
ijpds-3217	6	21	metabolism	metabolism	NOUN
ijpds-3217	6	22	of	of	ADP
ijpds-3217	6	23	carbohydrates	carbohydrate	NOUN
ijpds-3217	6	24	,	,	PUNCT
ijpds-3217	6	25	lipids	lipid	NOUN
ijpds-3217	6	26	,	,	PUNCT
ijpds-3217	6	27	and	and	CCONJ
ijpds-3217	6	28	proteins	protein	NOUN
ijpds-3217	6	29	.	.	PUNCT
ijpds-3217	7	1	it	it	PRON
ijpds-3217	7	2	requires	require	VERB
ijpds-3217	7	3	a	a	DET
ijpds-3217	7	4	lot	lot	NOUN
ijpds-3217	7	5	of	of	ADP
ijpds-3217	7	6	attention	attention	NOUN
ijpds-3217	7	7	,	,	PUNCT
ijpds-3217	7	8	as	as	ADP
ijpds-3217	7	9	its	its	PRON
ijpds-3217	7	10	complications	complication	NOUN
ijpds-3217	7	11	l	l	NOUN
ijpds-3217	7	12	ead	ead	NOUN
ijpds-3217	7	13	to	to	ADP
ijpds-3217	7	14	serious	serious	ADJ
ijpds-3217	7	15	health	health	NOUN
ijpds-3217	7	16	damage	damage	NOUN
ijpds-3217	7	17	and	and	CCONJ
ijpds-3217	7	18	even	even	ADV
ijpds-3217	7	19	death	death	NOUN
ijpds-3217	7	20	.	.	PUNCT
ijpds-3217	8	1	hydrochlorothiazide	hydrochlorothiazide	PROPN
ijpds-3217	8	2	(	(	PUNCT
ijpds-3217	8	3	hctz	hctz	PROPN
ijpds-3217	8	4	)	)	PUNCT
ijpds-3217	8	5	is	be	AUX
ijpds-3217	8	6	a	a	DET
ijpds-3217	8	7	diuretic	diuretic	NOUN
ijpds-3217	8	8	that	that	PRON
ijpds-3217	8	9	is	be	AUX
ijpds-3217	8	10	well	well	ADV
ijpds-3217	8	11	-	-	PUNCT
ijpds-3217	8	12	tolerated	tolerate	VERB
ijpds-3217	8	13	in	in	ADP
ijpds-3217	8	14	antihypertensive	antihypertensive	ADJ
ijpds-3217	8	15	treatments	treatment	NOUN
ijpds-3217	8	16	,	,	PUNCT
ijpds-3217	8	17	it	it	PRON
ijpds-3217	8	18	reduces	reduce	VERB
ijpds-3217	8	19	blood	blood	NOUN
ijpds-3217	8	20	volume	volume	NOUN
ijpds-3217	8	21	and	and	CCONJ
ijpds-3217	8	22	,	,	PUNCT
ijpds-3217	8	23	therefore	therefore	ADV
ijpds-3217	8	24	,	,	PUNCT
ijpds-3217	8	25	decreases	decrease	VERB
ijpds-3217	8	26	peripheral	peripheral	ADJ
ijpds-3217	8	27	vascular	vascular	ADJ
ijpds-3217	8	28	resistance	resistance	NOUN
ijpds-3217	8	29	.	.	PUNCT
ijpds-3217	9	1	however	however	ADV
ijpds-3217	9	2	,	,	PUNCT
ijpds-3217	9	3	there	there	PRON
ijpds-3217	9	4	are	be	VERB
ijpds-3217	9	5	some	some	DET
ijpds-3217	9	6	comments	comment	NOUN
ijpds-3217	9	7	in	in	ADP
ijpds-3217	9	8	the	the	DET
ijpds-3217	9	9	literature	literature	NOUN
ijpds-3217	9	10	on	on	ADP
ijpds-3217	9	11	the	the	DET
ijpds-3217	9	12	possibility	possibility	NOUN
ijpds-3217	9	13	that	that	SCONJ
ijpds-3217	9	14	high	high	ADJ
ijpds-3217	9	15	blood	blood	NOUN
ijpds-3217	9	16	concentrations	concentration	NOUN
ijpds-3217	9	17	of	of	ADP
ijpds-3217	9	18	blood	blood	NOUN
ijpds-3217	9	19	glucose	glucose	NOUN
ijpds-3217	9	20	(	(	PUNCT
ijpds-3217	9	21	glu	glu	NOUN
ijpds-3217	9	22	)	)	PUNCT
ijpds-3217	9	23	induce	induce	VERB
ijpds-3217	9	24	tolerance	tolerance	NOUN
ijpds-3217	9	25	and	and	CCONJ
ijpds-3217	9	26	cause	cause	VERB
ijpds-3217	9	27	adverse	adverse	ADJ
ijpds-3217	9	28	metabolic	metabolic	NOUN
ijpds-3217	9	29	effects	effect	NOUN
ijpds-3217	9	30	,	,	PUNCT
ijpds-3217	9	31	which	which	PRON
ijpds-3217	9	32	might	might	AUX
ijpds-3217	9	33	generate	generate	VERB
ijpds-3217	9	34	clinical	clinical	ADJ
ijpds-3217	9	35	complications	complication	NOUN
ijpds-3217	9	36	.	.	PUNCT
ijpds-3217	10	1	this	this	DET
ijpds-3217	10	2	study	study	NOUN
ijpds-3217	10	3	aimed	aim	VERB
ijpds-3217	10	4	to	to	PART
ijpds-3217	10	5	present	present	VERB
ijpds-3217	10	6	results	result	NOUN
ijpds-3217	10	7	by	by	ADP
ijpds-3217	10	8	using	use	VERB
ijpds-3217	10	9	circular	circular	ADJ
ijpds-3217	10	10	dichroism	dichroism	NOUN
ijpds-3217	10	11	(	(	PUNCT
ijpds-3217	10	12	f	f	PROPN
ijpds-3217	10	13	ar	ar	PROPN
ijpds-3217	10	14	and	and	CCONJ
ijpds-3217	10	15	near	near	ADP
ijpds-3217	10	16	uv	uv	NOUN
ijpds-3217	10	17	)	)	PUNCT
ijpds-3217	10	18	to	to	PART
ijpds-3217	10	19	study	study	VERB
ijpds-3217	10	20	the	the	DET
ijpds-3217	10	21	interaction	interaction	NOUN
ijpds-3217	10	22	between	between	ADP
ijpds-3217	10	23	human	human	ADJ
ijpds-3217	10	24	serum	serum	NOUN
ijpds-3217	10	25	albumin	albumin	PROPN
ijpds-3217	10	26	(	(	PUNCT
ijpds-3217	10	27	hsa	hsa	PROPN
ijpds-3217	10	28	)	)	PUNCT
ijpds-3217	10	29	and	and	CCONJ
ijpds-3217	10	30	hydrochlorothiazide	hydrochlorothiazide	VERB
ijpds-3217	10	31	in	in	ADP
ijpds-3217	10	32	the	the	DET
ijpds-3217	10	33	absence	absence	NOUN
ijpds-3217	10	34	and	and	CCONJ
ijpds-3217	10	35	presence	presence	NOUN
ijpds-3217	10	36	of	of	ADP
ijpds-3217	10	37	glucose	glucose	NOUN
ijpds-3217	10	38	at	at	ADP
ijpds-3217	10	39	37ºc	37ºc	ADJ
ijpds-3217	10	40	.	.	PUNCT
ijpds-3217	11	1	methodsexperimental	methodsexperimental	ADJ
ijpds-3217	11	2	data	datum	NOUN
ijpds-3217	11	3	were	be	AUX
ijpds-3217	11	4	correlated	correlate	VERB
ijpds-3217	11	5	for	for	ADP
ijpds-3217	11	6	theoretical	theoretical	ADJ
ijpds-3217	11	7	analysis	analysis	NOUN
ijpds-3217	11	8	through	through	ADP
ijpds-3217	11	9	molecular	molecular	ADJ
ijpds-3217	11	10	docking	docking	NOUN
ijpds-3217	11	11	simulations	simulation	NOUN
ijpds-3217	11	12	.	.	PUNCT
ijpds-3217	12	1	th	th	X
ijpds-3217	12	2	e	e	NOUN
ijpds-3217	12	3	ability	ability	NOUN
ijpds-3217	12	4	of	of	ADP
ijpds-3217	12	5	hydrochlorothiazide	hydrochlorothiazide	NOUN
ijpds-3217	12	6	to	to	PART
ijpds-3217	12	7	bind	bind	VERB
ijpds-3217	12	8	with	with	ADP
ijpds-3217	12	9	hsa	hsa	PROPN
ijpds-3217	12	10	was	be	AUX
ijpds-3217	12	11	verified	verify	VERB
ijpds-3217	12	12	in	in	ADP
ijpds-3217	12	13	normoglycemic	normoglycemic	NOUN
ijpds-3217	12	14	(	(	PUNCT
ijpds-3217	12	15	containing	contain	VERB
ijpds-3217	12	16	glucose	glucose	NOUN
ijpds-3217	12	17	80	80	NUM
ijpds-3217	12	18	mg	mg	PROPN
ijpds-3217	12	19	/	/	SYM
ijpds-3217	12	20	dl	dl	PROPN
ijpds-3217	12	21	)	)	PUNCT
ijpds-3217	12	22	and	and	CCONJ
ijpds-3217	12	23	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	12	24	(	(	PUNCT
ijpds-3217	12	25	containing	contain	VERB
ijpds-3217	12	26	glucose	glucose	NOUN
ijpds-3217	12	27	320	320	NUM
ijpds-3217	12	28	mg	mg	PROPN
ijpds-3217	12	29	/	/	SYM
ijpds-3217	12	30	dl	dl	NOUN
ijpds-3217	12	31	)	)	PUNCT
ijpds-3217	12	32	solutions	solution	NOUN
ijpds-3217	12	33	.	.	PUNCT
ijpds-3217	13	1	far	far	ADV
ijpds-3217	13	2	-	-	PUNCT
ijpds-3217	13	3	uv	uv	NOUN
ijpds-3217	13	4	analysis	analysis	NOUN
ijpds-3217	13	5	showed	show	VERB
ijpds-3217	13	6	that	that	SCONJ
ijpds-3217	13	7	hctz	hctz	PROPN
ijpds-3217	13	8	caused	cause	VERB
ijpds-3217	13	9	little	little	ADJ
ijpds-3217	13	10	perturbation	perturbation	NOUN
ijpds-3217	13	11	on	on	ADP
ijpds-3217	13	12	the	the	DET
ijpds-3217	13	13	secondary	secondary	ADJ
ijpds-3217	13	14	structure	structure	NOUN
ijpds-3217	13	15	of	of	ADP
ijpds-3217	13	16	albumin	albumin	NOUN
ijpds-3217	13	17	for	for	ADP
ijpds-3217	13	18	the	the	DET
ijpds-3217	13	19	three	three	NUM
ijpds-3217	13	20	hsa	hsa	NOUN
ijpds-3217	13	21	:	:	PUNCT
ijpds-3217	13	22	hctz	hctz	PROPN
ijpds-3217	13	23	ratios	ratio	NOUN
ijpds-3217	13	24	(	(	PUNCT
ijpds-3217	13	25	1:12	1:12	NUM
ijpds-3217	13	26	,	,	PUNCT
ijpds-3217	13	27	1:24	1:24	NUM
ijpds-3217	13	28	,	,	PUNCT
ijpds-3217	13	29	and	and	CCONJ
ijpds-3217	13	30	1:48	1:48	NUM
ijpds-3217	13	31	)	)	PUNCT
ijpds-3217	13	32	.	.	PUNCT
ijpds-3217	14	1	we	we	PRON
ijpds-3217	14	2	observed	observe	VERB
ijpds-3217	14	3	a	a	DET
ijpds-3217	14	4	strong	strong	ADJ
ijpds-3217	14	5	disturbance	disturbance	NOUN
ijpds-3217	14	6	in	in	ADP
ijpds-3217	14	7	the	the	DET
ijpds-3217	14	8	secondary	secondary	ADJ
ijpds-3217	14	9	structure	structure	NOUN
ijpds-3217	14	10	of	of	ADP
ijpds-3217	14	11	albumin	albumin	NOUN
ijpds-3217	14	12	was	be	AUX
ijpds-3217	14	13	for	for	ADP
ijpds-3217	14	14	glu	glu	NOUN
ijpds-3217	14	15	in	in	ADP
ijpds-3217	14	16	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	14	17	concentration	concentration	NOUN
ijpds-3217	14	18	,	,	PUNCT
ijpds-3217	14	19	with	with	ADP
ijpds-3217	14	20	a	a	DET
ijpds-3217	14	21	maximum	maximum	ADJ
ijpds-3217	14	22	reduction	reduction	NOUN
ijpds-3217	14	23	of	of	ADP
ijpds-3217	14	24	12.66	12.66	NUM
ijpds-3217	14	25	%	%	NOUN
ijpds-3217	14	26	at	at	ADP
ijpds-3217	14	27	222	222	NUM
ijpds-3217	14	28	nm	nm	NOUN
ijpds-3217	14	29	.	.	PUNCT
ijpds-3217	15	1	an	an	DET
ijpds-3217	15	2	increase	increase	NOUN
ijpds-3217	15	3	in	in	ADP
ijpds-3217	15	4	the	the	DET
ijpds-3217	15	5	blood	blood	NOUN
ijpds-3217	15	6	glu	glu	NOUN
ijpds-3217	15	7	level	level	NOUN
ijpds-3217	15	8	causes	cause	VERB
ijpds-3217	15	9	a	a	DET
ijpds-3217	15	10	functional	functional	ADJ
ijpds-3217	15	11	perturbation	perturbation	NOUN
ijpds-3217	15	12	in	in	ADP
ijpds-3217	15	13	the	the	DET
ijpds-3217	15	14	binding	binding	NOUN
ijpds-3217	15	15	of	of	ADP
ijpds-3217	15	16	hctz	hctz	PROPN
ijpds-3217	15	17	with	with	ADP
ijpds-3217	15	18	hsa	hsa	PROPN
ijpds-3217	15	19	.	.	PUNCT
ijpds-3217	16	1	hctzhsa	hctzhsa	NOUN
ijpds-3217	16	2	binding	bind	VERB
ijpds-3217	16	3	is	be	AUX
ijpds-3217	16	4	spontaneous	spontaneous	ADJ
ijpds-3217	16	5	and	and	CCONJ
ijpds-3217	16	6	causes	cause	VERB
ijpds-3217	16	7	weak	weak	ADJ
ijpds-3217	16	8	perturbation	perturbation	NOUN
ijpds-3217	16	9	on	on	ADP
ijpds-3217	16	10	the	the	DET
ijpds-3217	16	11	secondary	secondary	ADJ
ijpds-3217	16	12	and	and	CCONJ
ijpds-3217	16	13	tertiary	tertiary	ADJ
ijpds-3217	16	14	structure	structure	NOUN
ijpds-3217	16	15	of	of	ADP
ijpds-3217	16	16	albumin	albumin	NOUN
ijpds-3217	16	17	,	,	PUNCT
ijpds-3217	16	18	however	however	ADV
ijpds-3217	16	19	,	,	PUNCT
ijpds-3217	16	20	at	at	ADP
ijpds-3217	16	21	high	high	ADJ
ijpds-3217	16	22	glu	glu	NOUN
ijpds-3217	16	23	concentration	concentration	NOUN
ijpds-3217	16	24	,	,	PUNCT
ijpds-3217	16	25	the	the	DET
ijpds-3217	16	26	perturbation	perturbation	NOUN
ijpds-3217	16	27	increases	increase	NOUN
ijpds-3217	16	28	which	which	PRON
ijpds-3217	16	29	makes	make	VERB
ijpds-3217	16	30	the	the	DET
ijpds-3217	16	31	albumin	albumin	ADJ
ijpds-3217	16	32	structure	structure	NOUN
ijpds-3217	16	33	unstable	unstable	ADJ
ijpds-3217	16	34	.	.	PUNCT
ijpds-3217	17	1	key	key	ADJ
ijpds-3217	17	2	words	word	NOUN
ijpds-3217	17	3	:	:	PUNCT
ijpds-3217	17	4	diabetes	diabetes	NOUN
ijpds-3217	17	5	mellitus	mellitus	NOUN
ijpds-3217	17	6	,	,	PUNCT
ijpds-3217	17	7	glucose	glucose	NOUN
ijpds-3217	17	8	,	,	PUNCT
ijpds-3217	17	9	hydrochlorothiazide	hydrochlorothiazide	NOUN
ijpds-3217	17	10	,	,	PUNCT
ijpds-3217	17	11	human	human	ADJ
ijpds-3217	17	12	serum	serum	NOUN
ijpds-3217	17	13	albumin	albumin	PROPN
ijpds-3217	17	14	,	,	PUNCT
ijpds-3217	17	15	cd	cd	NOUN
ijpds-3217	17	16	-	-	PUNCT
ijpds-3217	17	17	spectroscopy	spectroscopy	NOUN
ijpds-3217	17	18	,	,	PUNCT
ijpds-3217	17	19	molecular	molecular	ADJ
ijpds-3217	17	20	docking	docking	NOUN
ijpds-3217	17	21	n	n	CCONJ
ijpds-3217	17	22	the	the	DET
ijpds-3217	17	23	study	study	NOUN
ijpds-3217	17	24	performed	perform	VERB
ijpds-3217	17	25	by	by	ADP
ijpds-3217	17	26	soares	soare	NOUN
ijpds-3217	17	27	.	.	PUNCT
ijpds-3217	18	1	et	et	PROPN
ijpds-3217	18	2	al	al	PROPN
ijpds-3217	18	3	we	we	PRON
ijpds-3217	18	4	saw	see	VERB
ijpds-3217	18	5	the	the	DET
ijpds-3217	18	6	interaction	interaction	NOUN
ijpds-3217	18	7	of	of	ADP
ijpds-3217	18	8	hsa	hsa	PROPN
ijpds-3217	18	9	with	with	ADP
ijpds-3217	18	10	hydrochlorothiazide	hydrochlorothiazide	PROPN
ijpds-3217	18	11	(	(	PUNCT
ijpds-3217	18	12	hctz	hctz	NOUN
ijpds-3217	18	13	)	)	PUNCT
ijpds-3217	18	14	in	in	ADP
ijpds-3217	18	15	both	both	CCONJ
ijpds-3217	18	16	the	the	DET
ijpds-3217	18	17	absence	absence	NOUN
ijpds-3217	18	18	and	and	CCONJ
ijpds-3217	18	19	presence	presence	NOUN
ijpds-3217	18	20	of	of	ADP
ijpds-3217	18	21	glucose	glucose	NOUN
ijpds-3217	18	22	using	use	VERB
ijpds-3217	18	23	uv	uv	NOUN
ijpds-3217	18	24	-	-	PUNCT
ijpds-3217	18	25	vis	vis	X
ijpds-3217	18	26	absorption	absorption	NOUN
ijpds-3217	18	27	and	and	CCONJ
ijpds-3217	18	28	spectro	spectro	PROPN
ijpds-3217	18	29	fluorescence	fluorescence	NOUN
ijpds-3217	18	30	spectroscopy	spectroscopy	VERB
ijpds-3217	18	31	at	at	ADP
ijpds-3217	18	32	37	37	NUM
ijpds-3217	18	33	ºc	ºc	NOUN
ijpds-3217	18	34	.	.	PUNCT
ijpds-3217	19	1	the	the	DET
ijpds-3217	19	2	study	study	NOUN
ijpds-3217	19	3	also	also	ADV
ijpds-3217	19	4	demonstrated	demonstrate	VERB
ijpds-3217	19	5	competitive	competitive	ADJ
ijpds-3217	19	6	binding	binding	ADJ
ijpds-3217	19	7	using	use	VERB
ijpds-3217	19	8	warfarin	warfarin	NOUN
ijpds-3217	19	9	and	and	CCONJ
ijpds-3217	19	10	digitoxin	digitoxin	PROPN
ijpds-3217	19	11	,	,	PUNCT
ijpds-3217	19	12	markers	marker	NOUN
ijpds-3217	19	13	for	for	ADP
ijpds-3217	19	14	sudlow	sudlow	ADJ
ijpds-3217	19	15	i	i	PROPN
ijpds-3217	19	16	and	and	CCONJ
ijpds-3217	19	17	sudlow	sudlow	PROPN
ijpds-3217	19	18	iii	iii	PROPN
ijpds-3217	19	19	sites	site	NOUN
ijpds-3217	19	20	,	,	PUNCT
ijpds-3217	19	21	respectively	respectively	ADV
ijpds-3217	19	22	.	.	PUNCT
ijpds-3217	20	1	as	as	SCONJ
ijpds-3217	20	2	this	this	DET
ijpds-3217	20	3	drug	drug	NOUN
ijpds-3217	20	4	was	be	AUX
ijpds-3217	20	5	used	use	VERB
ijpds-3217	20	6	in	in	ADP
ijpds-3217	20	7	the	the	DET
ijpds-3217	20	8	treatment	treatment	NOUN
ijpds-3217	20	9	of	of	ADP
ijpds-3217	20	10	hypertensive	hypertensive	ADJ
ijpds-3217	20	11	diabetic	diabetic	ADJ
ijpds-3217	20	12	patients	patient	NOUN
ijpds-3217	20	13	,	,	PUNCT
ijpds-3217	20	14	we	we	PRON
ijpds-3217	20	15	were	be	AUX
ijpds-3217	20	16	interested	interested	ADJ
ijpds-3217	20	17	in	in	ADP
ijpds-3217	20	18	verifying	verify	VERB
ijpds-3217	20	19	if	if	SCONJ
ijpds-3217	20	20	blood	blood	NOUN
ijpds-3217	20	21	glucose	glucose	NOUN
ijpds-3217	20	22	(	(	PUNCT
ijpds-3217	20	23	glu	glu	NOUN
ijpds-3217	20	24	)	)	PUNCT
ijpds-3217	20	25	concentration	concentration	NOUN
ijpds-3217	20	26	could	could	AUX
ijpds-3217	20	27	interfere	interfere	VERB
ijpds-3217	20	28	with	with	ADP
ijpds-3217	20	29	this	this	DET
ijpds-3217	20	30	drug	drug	NOUN
ijpds-3217	20	31	-	-	PUNCT
ijpds-3217	20	32	protein	protein	NOUN
ijpds-3217	20	33	interaction	interaction	NOUN
ijpds-3217	20	34	.	.	PUNCT
ijpds-3217	21	1	for	for	ADP
ijpds-3217	21	2	this	this	PRON
ijpds-3217	21	3	,	,	PUNCT
ijpds-3217	21	4	hsa	hsa	PROPN
ijpds-3217	21	5	solutions	solution	NOUN
ijpds-3217	21	6	containing	contain	VERB
ijpds-3217	21	7	glu	glu	NOUN
ijpds-3217	21	8	80	80	NUM
ijpds-3217	21	9	mg	mg	PROPN
ijpds-3217	21	10	/	/	SYM
ijpds-3217	21	11	dl	dl	PROPN
ijpds-3217	21	12	and	and	CCONJ
ijpds-3217	21	13	320	320	NUM
ijpds-3217	21	14	mg	mg	PROPN
ijpds-3217	21	15	/	/	SYM
ijpds-3217	21	16	dl	dl	PROPN
ijpds-3217	21	17	were	be	AUX
ijpds-3217	21	18	used	use	VERB
ijpds-3217	21	19	named	name	VERB
ijpds-3217	21	20	normoglycemic	normoglycemic	ADJ
ijpds-3217	21	21	and	and	CCONJ
ijpds-3217	21	22	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	21	23	solutions	solution	NOUN
ijpds-3217	21	24	,	,	PUNCT
ijpds-3217	21	25	respectively	respectively	ADV
ijpds-3217	21	26	.	.	PUNCT
ijpds-3217	22	1	diabetes	diabetes	NOUN
ijpds-3217	22	2	mellitus	mellitus	NOUN
ijpds-3217	22	3	(	(	PUNCT
ijpds-3217	22	4	dm	dm	PROPN
ijpds-3217	22	5	)	)	PUNCT
ijpds-3217	22	6	is	be	AUX
ijpds-3217	22	7	a	a	DET
ijpds-3217	22	8	chronic	chronic	ADJ
ijpds-3217	22	9	disease	disease	NOUN
ijpds-3217	22	10	characterized	characterize	VERB
ijpds-3217	22	11	by	by	ADP
ijpds-3217	22	12	high	high	ADJ
ijpds-3217	22	13	blood	blood	NOUN
ijpds-3217	22	14	sugar	sugar	NOUN
ijpds-3217	22	15	levels	level	NOUN
ijpds-3217	22	16	,	,	PUNCT
ijpds-3217	22	17	resulting	result	VERB
ijpds-3217	22	18	from	from	ADP
ijpds-3217	22	19	reduced	reduced	ADJ
ijpds-3217	22	20	or	or	CCONJ
ijpds-3217	22	21	non	non	ADJ
ijpds-3217	22	22	-	-	ADJ
ijpds-3217	22	23	insulin	insulin	ADJ
ijpds-3217	22	24	production	production	NOUN
ijpds-3217	22	25	and/or	and/or	CCONJ
ijpds-3217	22	26	reduced	reduce	VERB
ijpds-3217	22	27	tissue	tissue	NOUN
ijpds-3217	22	28	sensitivity	sensitivity	NOUN
ijpds-3217	22	29	[	[	X
ijpds-3217	22	30	2	2	NUM
ijpds-3217	22	31	]	]	PUNCT
ijpds-3217	22	32	.	.	PUNCT
ijpds-3217	23	1	hyperglycemia	hyperglycemia	NOUN
ijpds-3217	23	2	is	be	AUX
ijpds-3217	23	3	accompanied	accompany	VERB
ijpds-3217	23	4	by	by	ADP
ijpds-3217	23	5	disturbances	disturbance	NOUN
ijpds-3217	23	6	in	in	ADP
ijpds-3217	23	7	the	the	DET
ijpds-3217	23	8	metabolism	metabolism	NOUN
ijpds-3217	23	9	of	of	ADP
ijpds-3217	23	10	carbohydrates	carbohydrate	NOUN
ijpds-3217	23	11	,	,	PUNCT
ijpds-3217	23	12	lipids	lipid	NOUN
ijpds-3217	23	13	,	,	PUNCT
ijpds-3217	23	14	and	and	CCONJ
ijpds-3217	23	15	proteins	protein	NOUN
ijpds-3217	23	16	.	.	PUNCT
ijpds-3217	24	1	it	it	PRON
ijpds-3217	24	2	is	be	AUX
ijpds-3217	24	3	a	a	DET
ijpds-3217	24	4	disease	disease	NOUN
ijpds-3217	24	5	that	that	PRON
ijpds-3217	24	6	requires	require	VERB
ijpds-3217	24	7	a	a	DET
ijpds-3217	24	8	lot	lot	NOUN
ijpds-3217	24	9	of	of	ADP
ijpds-3217	24	10	attention	attention	NOUN
ijpds-3217	24	11	,	,	PUNCT
ijpds-3217	24	12	as	as	SCONJ
ijpds-3217	24	13	its	its	PRON
ijpds-3217	24	14	complications	complication	NOUN
ijpds-3217	24	15	can	can	AUX
ijpds-3217	24	16	cause	cause	VERB
ijpds-3217	24	17	serious	serious	ADJ
ijpds-3217	24	18	health	health	NOUN
ijpds-3217	24	19	damage	damage	NOUN
ijpds-3217	24	20	and	and	CCONJ
ijpds-3217	24	21	even	even	ADV
ijpds-3217	24	22	death	death	NOUN
ijpds-3217	24	23	,	,	PUNCT
ijpds-3217	24	24	especially	especially	ADV
ijpds-3217	24	25	among	among	ADP
ijpds-3217	24	26	young	young	ADJ
ijpds-3217	24	27	people	people	NOUN
ijpds-3217	25	1	[	[	X
ijpds-3217	25	2	3	3	X
ijpds-3217	25	3	]	]	X
ijpds-3217	25	4	[	[	X
ijpds-3217	25	5	4	4	NUM
ijpds-3217	25	6	]	]	PUNCT
ijpds-3217	25	7	.	.	PUNCT
ijpds-3217	26	1	by	by	ADP
ijpds-3217	26	2	its	its	PRON
ijpds-3217	26	3	diuretic	diuretic	ADJ
ijpds-3217	26	4	effect	effect	NOUN
ijpds-3217	26	5	,	,	PUNCT
ijpds-3217	26	6	hctz	hctz	NOUN
ijpds-3217	26	7	reduces	reduce	VERB
ijpds-3217	26	8	blood	blood	NOUN
ijpds-3217	26	9	volume	volume	NOUN
ijpds-3217	26	10	and	and	CCONJ
ijpds-3217	26	11	,	,	PUNCT
ijpds-3217	26	12	therefore	therefore	ADV
ijpds-3217	26	13	,	,	PUNCT
ijpds-3217	26	14	decreases	decrease	VERB
ijpds-3217	26	15	peripheral	peripheral	ADJ
ijpds-3217	26	16	vascular	vascular	ADJ
ijpds-3217	26	17	resistance	resistance	NOUN
ijpds-3217	26	18	,	,	PUNCT
ijpds-3217	26	19	being	be	AUX
ijpds-3217	26	20	in	in	ADP
ijpds-3217	26	21	general	general	ADJ
ijpds-3217	26	22	a	a	DET
ijpds-3217	26	23	well	well	ADV
ijpds-3217	26	24	-	-	PUNCT
ijpds-3217	26	25	tolerated	tolerate	VERB
ijpds-3217	26	26	drug	drug	NOUN
ijpds-3217	26	27	in	in	ADP
ijpds-3217	26	28	antihypertensive	antihypertensive	ADJ
ijpds-3217	26	29	treatments	treatment	NOUN
ijpds-3217	26	30	[	[	X
ijpds-3217	26	31	5	5	X
ijpds-3217	26	32	]	]	X
ijpds-3217	27	1	[	[	X
ijpds-3217	27	2	6	6	NUM
ijpds-3217	27	3	]	]	X
ijpds-3217	27	4	[	[	X
ijpds-3217	27	5	7	7	NUM
ijpds-3217	27	6	]	]	PUNCT
ijpds-3217	27	7	.	.	PUNCT
ijpds-3217	28	1	however	however	ADV
ijpds-3217	28	2	,	,	PUNCT
ijpds-3217	28	3	there	there	PRON
ijpds-3217	28	4	are	be	VERB
ijpds-3217	28	5	some	some	DET
ijpds-3217	28	6	comments	comment	NOUN
ijpds-3217	28	7	in	in	ADP
ijpds-3217	28	8	the	the	DET
ijpds-3217	28	9	literature	literature	NOUN
ijpds-3217	28	10	on	on	ADP
ijpds-3217	28	11	the	the	DET
ijpds-3217	28	12	possibility	possibility	NOUN
ijpds-3217	28	13	that	that	SCONJ
ijpds-3217	28	14	high	high	ADJ
ijpds-3217	28	15	blood	blood	NOUN
ijpds-3217	28	16	concentrations	concentration	NOUN
ijpds-3217	28	17	of	of	ADP
ijpds-3217	28	18	glu	glu	NOUN
ijpds-3217	28	19	induce	induce	VERB
ijpds-3217	28	20	tolerance	tolerance	NOUN
ijpds-3217	28	21	and	and	CCONJ
ijpds-3217	28	22	cause	cause	VERB
ijpds-3217	28	23	adverse	adverse	ADJ
ijpds-3217	28	24	metabolic	metabolic	NOUN
ijpds-3217	28	25	effects	effect	NOUN
ijpds-3217	28	26	,	,	PUNCT
ijpds-3217	28	27	which	which	PRON
ijpds-3217	28	28	might	might	AUX
ijpds-3217	28	29	generate	generate	VERB
ijpds-3217	28	30	clinical	clinical	ADJ
ijpds-3217	28	31	complications	complication	NOUN
ijpds-3217	28	32	[	[	X
ijpds-3217	28	33	8	8	X
ijpds-3217	28	34	]	]	X
ijpds-3217	29	1	[	[	X
ijpds-3217	29	2	9	9	NUM
ijpds-3217	29	3	]	]	X
ijpds-3217	29	4	[	[	X
ijpds-3217	29	5	10	10	NUM
ijpds-3217	29	6	]	]	X
ijpds-3217	30	1	[	[	X
ijpds-3217	30	2	11	11	NUM
ijpds-3217	30	3	]	]	PUNCT
ijpds-3217	30	4	.	.	PUNCT
ijpds-3217	31	1	g	g	PROPN
ijpds-3217	31	2	however	however	ADV
ijpds-3217	31	3	,	,	PUNCT
ijpds-3217	31	4	some	some	DET
ijpds-3217	31	5	studies	study	NOUN
ijpds-3217	31	6	disagree	disagree	VERB
ijpds-3217	31	7	with	with	ADP
ijpds-3217	31	8	these	these	DET
ijpds-3217	31	9	opinions	opinion	NOUN
ijpds-3217	31	10	[	[	X
ijpds-3217	31	11	12	12	NUM
ijpds-3217	31	12	]	]	PUNCT
ijpds-3217	31	13	,	,	PUNCT
ijpds-3217	31	14	suggesting	suggest	VERB
ijpds-3217	31	15	longterm	longterm	NOUN
ijpds-3217	31	16	use	use	NOUN
ijpds-3217	31	17	and	and	CCONJ
ijpds-3217	31	18	high	high	ADJ
ijpds-3217	31	19	doses	dose	NOUN
ijpds-3217	31	20	(	(	PUNCT
ijpds-3217	31	21	>	>	SYM
ijpds-3217	31	22	50	50	NUM
ijpds-3217	31	23	mg	mg	NUM
ijpds-3217	31	24	/	/	SYM
ijpds-3217	31	25	day	day	NOUN
ijpds-3217	31	26	)	)	PUNCT
ijpds-3217	31	27	as	as	ADP
ijpds-3217	31	28	factors	factor	NOUN
ijpds-3217	31	29	that	that	PRON
ijpds-3217	31	30	may	may	AUX
ijpds-3217	31	31	be	be	AUX
ijpds-3217	31	32	behind	behind	ADP
ijpds-3217	31	33	the	the	DET
ijpds-3217	31	34	adverse	adverse	ADJ
ijpds-3217	31	35	effects	effect	NOUN
ijpds-3217	31	36	of	of	ADP
ijpds-3217	31	37	hctz	hctz	PROPN
ijpds-3217	31	38	[	[	X
ijpds-3217	31	39	13	13	NUM
ijpds-3217	31	40	]	]	PUNCT
ijpds-3217	32	1	[	[	X
ijpds-3217	32	2	14	14	NUM
ijpds-3217	32	3	]	]	PUNCT
ijpds-3217	32	4	.	.	PUNCT
ijpds-3217	33	1	the	the	DET
ijpds-3217	33	2	comparison	comparison	NOUN
ijpds-3217	33	3	of	of	ADP
ijpds-3217	33	4	our	our	PRON
ijpds-3217	33	5	results	result	NOUN
ijpds-3217	33	6	of	of	ADP
ijpds-3217	33	7	the	the	DET
ijpds-3217	33	8	experiments	experiment	NOUN
ijpds-3217	33	9	using	use	VERB
ijpds-3217	33	10	spectrofluorescence	spectrofluorescence	NOUN
ijpds-3217	33	11	and	and	CCONJ
ijpds-3217	33	12	uv	uv	NOUN
ijpds-3217	33	13	-	-	PUNCT
ijpds-3217	33	14	vis	vis	X
ijpds-3217	33	15	spectroscopy	spectroscopy	NOUN
ijpds-3217	33	16	showed	show	VERB
ijpds-3217	33	17	that	that	SCONJ
ijpds-3217	33	18	the	the	DET
ijpds-3217	33	19	microenvironment	microenvironment	ADJ
ijpds-3217	33	20	disturbance	disturbance	NOUN
ijpds-3217	33	21	around	around	ADP
ijpds-3217	33	22	aromatic	aromatic	ADJ
ijpds-3217	33	23	amino	amino	NOUN
ijpds-3217	33	24	acid	acid	NOUN
ijpds-3217	33	25	residues	residue	NOUN
ijpds-3217	33	26	of	of	ADP
ijpds-3217	33	27	hsa	hsa	NOUN
ijpds-3217	33	28	by	by	ADP
ijpds-3217	33	29	its	its	PRON
ijpds-3217	33	30	interaction	interaction	NOUN
ijpds-3217	33	31	with	with	ADP
ijpds-3217	33	32	hctz	hctz	PROPN
ijpds-3217	33	33	was	be	AUX
ijpds-3217	33	34	considerably	considerably	ADV
ijpds-3217	33	35	greater	great	ADJ
ijpds-3217	33	36	in	in	ADP
ijpds-3217	33	37	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	33	38	solution	solution	NOUN
ijpds-3217	33	39	than	than	ADP
ijpds-3217	33	40	in	in	ADP
ijpds-3217	33	41	normoglycemic	normoglycemic	ADJ
ijpds-3217	33	42	solution	solution	NOUN
ijpds-3217	33	43	[	[	X
ijpds-3217	33	44	15	15	NUM
ijpds-3217	33	45	]	]	PUNCT
ijpds-3217	33	46	.	.	PUNCT
ijpds-3217	34	1	the	the	DET
ijpds-3217	34	2	fluorescence	fluorescence	NOUN
ijpds-3217	34	3	quenching	quenching	NOUN
ijpds-3217	34	4	experiments	experiment	NOUN
ijpds-3217	34	5	showed	show	VERB
ijpds-3217	34	6	that	that	SCONJ
ijpds-3217	34	7	this	this	DET
ijpds-3217	34	8	drug	drug	NOUN
ijpds-3217	34	9	binds	bind	VERB
ijpds-3217	34	10	to	to	ADP
ijpds-3217	34	11	albumin	albumin	NOUN
ijpds-3217	34	12	forming	form	VERB
ijpds-3217	34	13	a	a	DET
ijpds-3217	34	14	complex	complex	NOUN
ijpds-3217	34	15	in	in	ADP
ijpds-3217	34	16	the	the	DET
ijpds-3217	34	17	absence	absence	NOUN
ijpds-3217	34	18	that	that	PRON
ijpds-3217	34	19	might	might	AUX
ijpds-3217	34	20	generate	generate	VERB
ijpds-3217	34	21	a	a	DET
ijpds-3217	34	22	conformational	conformational	ADJ
ijpds-3217	34	23	change	change	NOUN
ijpds-3217	34	24	in	in	ADP
ijpds-3217	34	25	albumin	albumin	NOUN
ijpds-3217	34	26	and	and	CCONJ
ijpds-3217	34	27	a	a	DET
ijpds-3217	34	28	reduction	reduction	NOUN
ijpds-3217	34	29	in	in	ADP
ijpds-3217	34	30	the	the	DET
ijpds-3217	34	31	number	number	NOUN
ijpds-3217	34	32	of	of	ADP
ijpds-3217	34	33	sites	site	NOUN
ijpds-3217	34	34	available	available	ADJ
ijpds-3217	34	35	for	for	ADP
ijpds-3217	34	36	drug	drug	NOUN
ijpds-3217	34	37	binding	bind	VERB
ijpds-3217	34	38	in	in	ADP
ijpds-3217	34	39	the	the	DET
ijpds-3217	34	40	iia	iia	NOUN
ijpds-3217	34	41	subdomain	subdomain	NOUN
ijpds-3217	34	42	.	.	PUNCT
ijpds-3217	35	1	i	i	PRON
ijpds-3217	35	2	soares	soar	VERB
ijpds-3217	35	3	et	et	PROPN
ijpds-3217	35	4	al	al	PROPN
ijpds-3217	35	5	hsa	hsa	PROPN
ijpds-3217	35	6	-	-	PUNCT
ijpds-3217	35	7	hctz	hctz	ADJ
ijpds-3217	35	8	interactions	interaction	NOUN
ijpds-3217	35	9	based	base	VERB
ijpds-3217	35	10	on	on	ADP
ijpds-3217	35	11	glucose	glucose	NOUN
ijpds-3217	35	12	concentrations	concentration	NOUN
ijpds-3217	35	13	vol	vol	NOUN
ijpds-3217	35	14	1	1	NUM
ijpds-3217	35	15	|	|	NOUN
ijpds-3217	35	16	issue	issue	NOUN
ijpds-3217	35	17	2	2	NUM
ijpds-3217	36	1	|	|	ADV
ijpds-3217	36	2	jul	jul	PROPN
ijpds-3217	36	3	sep	sep	PROPN
ijpds-3217	36	4	2022	2022	NUM
ijpds-3217	36	5	indian	indian	PROPN
ijpds-3217	36	6	j	j	PROPN
ijpds-3217	36	7	pharm	pharm	PROPN
ijpds-3217	36	8	drug	drug	PROPN
ijpds-3217	36	9	studies	study	NOUN
ijpds-3217	36	10	|	|	ADV
ijpds-3217	36	11	57	57	NUM
ijpds-3217	36	12	as	as	SCONJ
ijpds-3217	36	13	the	the	DET
ijpds-3217	36	14	biodistribution	biodistribution	NOUN
ijpds-3217	36	15	and	and	CCONJ
ijpds-3217	36	16	effects	effect	NOUN
ijpds-3217	36	17	of	of	ADP
ijpds-3217	36	18	drugs	drug	NOUN
ijpds-3217	36	19	depend	depend	VERB
ijpds-3217	36	20	on	on	ADP
ijpds-3217	36	21	their	their	PRON
ijpds-3217	36	22	ability	ability	NOUN
ijpds-3217	36	23	to	to	PART
ijpds-3217	36	24	bind	bind	VERB
ijpds-3217	36	25	to	to	ADP
ijpds-3217	36	26	plasma	plasma	NOUN
ijpds-3217	36	27	proteins	protein	NOUN
ijpds-3217	36	28	,	,	PUNCT
ijpds-3217	36	29	especially	especially	ADV
ijpds-3217	36	30	albumin	albumin	ADJ
ijpds-3217	36	31	,	,	PUNCT
ijpds-3217	36	32	which	which	PRON
ijpds-3217	36	33	is	be	AUX
ijpds-3217	36	34	the	the	DET
ijpds-3217	36	35	main	main	ADJ
ijpds-3217	36	36	drug	drug	NOUN
ijpds-3217	36	37	transporter	transporter	NOUN
ijpds-3217	36	38	,	,	PUNCT
ijpds-3217	36	39	it	it	PRON
ijpds-3217	36	40	becomes	become	VERB
ijpds-3217	36	41	relevant	relevant	ADJ
ijpds-3217	36	42	to	to	PART
ijpds-3217	36	43	enlarge	enlarge	VERB
ijpds-3217	36	44	the	the	DET
ijpds-3217	36	45	study	study	NOUN
ijpds-3217	36	46	on	on	ADP
ijpds-3217	36	47	disturbances	disturbance	NOUN
ijpds-3217	36	48	caused	cause	VERB
ijpds-3217	36	49	by	by	ADP
ijpds-3217	36	50	elevated	elevated	ADJ
ijpds-3217	36	51	blood	blood	NOUN
ijpds-3217	36	52	glucose	glucose	NOUN
ijpds-3217	36	53	in	in	ADP
ijpds-3217	36	54	the	the	DET
ijpds-3217	36	55	hsa	hsa	PROPN
ijpds-3217	36	56	structure	structure	NOUN
ijpds-3217	36	57	and	and	CCONJ
ijpds-3217	36	58	in	in	ADP
ijpds-3217	36	59	the	the	DET
ijpds-3217	36	60	hctz	hctz	PROPN
ijpds-3217	36	61	-	-	PUNCT
ijpds-3217	36	62	hsa	hsa	PROPN
ijpds-3217	36	63	interaction	interaction	NOUN
ijpds-3217	36	64	.	.	PUNCT
ijpds-3217	37	1	circular	circular	ADJ
ijpds-3217	37	2	dichroism	dichroism	NOUN
ijpds-3217	37	3	(	(	PUNCT
ijpds-3217	37	4	cd	cd	NOUN
ijpds-3217	37	5	)	)	PUNCT
ijpds-3217	37	6	spectroscopy	spectroscopy	NOUN
ijpds-3217	37	7	is	be	AUX
ijpds-3217	37	8	a	a	DET
ijpds-3217	37	9	widespread	widespread	ADJ
ijpds-3217	37	10	technique	technique	NOUN
ijpds-3217	37	11	for	for	ADP
ijpds-3217	37	12	checking	check	VERB
ijpds-3217	37	13	perturbation	perturbation	NOUN
ijpds-3217	37	14	on	on	ADP
ijpds-3217	37	15	the	the	DET
ijpds-3217	37	16	secondary	secondary	ADJ
ijpds-3217	37	17	(	(	PUNCT
ijpds-3217	37	18	far	far	ADV
ijpds-3217	37	19	-	-	PUNCT
ijpds-3217	37	20	uv	uv	NOUN
ijpds-3217	37	21	)	)	PUNCT
ijpds-3217	37	22	and	and	CCONJ
ijpds-3217	37	23	tertiary	tertiary	ADJ
ijpds-3217	37	24	(	(	PUNCT
ijpds-3217	37	25	near	near	ADP
ijpds-3217	37	26	-	-	PUNCT
ijpds-3217	37	27	uv	uv	NOUN
ijpds-3217	37	28	)	)	PUNCT
ijpds-3217	37	29	structures	structure	NOUN
ijpds-3217	37	30	of	of	ADP
ijpds-3217	37	31	macromolecules	macromolecule	NOUN
ijpds-3217	37	32	upon	upon	SCONJ
ijpds-3217	37	33	ligand	ligand	NOUN
ijpds-3217	37	34	binding	bind	VERB
ijpds-3217	37	35	[	[	X
ijpds-3217	37	36	15	15	NUM
ijpds-3217	37	37	]	]	PUNCT
ijpds-3217	37	38	.	.	PUNCT
ijpds-3217	38	1	it	it	PRON
ijpds-3217	38	2	is	be	AUX
ijpds-3217	38	3	known	know	VERB
ijpds-3217	38	4	that	that	SCONJ
ijpds-3217	38	5	hsa	hsa	VERB
ijpds-3217	38	6	exhibits	exhibit	VERB
ijpds-3217	38	7	two	two	NUM
ijpds-3217	38	8	negative	negative	ADJ
ijpds-3217	38	9	bands	band	NOUN
ijpds-3217	38	10	in	in	ADP
ijpds-3217	38	11	the	the	DET
ijpds-3217	38	12	far	far	ADV
ijpds-3217	38	13	-	-	PUNCT
ijpds-3217	38	14	uv	uv	NOUN
ijpds-3217	38	15	:	:	PUNCT
ijpds-3217	38	16	one	one	NUM
ijpds-3217	38	17	at	at	ADP
ijpds-3217	38	18	208	208	NUM
ijpds-3217	38	19	nm	nm	NOUN
ijpds-3217	38	20	(	(	PUNCT
ijpds-3217	38	21	π	π	PROPN
ijpds-3217	38	22	-	-	PUNCT
ijpds-3217	38	23	π	π	PROPN
ijpds-3217	38	24	*	*	NOUN
ijpds-3217	38	25	transition	transition	NOUN
ijpds-3217	38	26	)	)	PUNCT
ijpds-3217	38	27	and	and	CCONJ
ijpds-3217	38	28	the	the	DET
ijpds-3217	38	29	other	other	ADJ
ijpds-3217	38	30	at	at	ADP
ijpds-3217	38	31	222	222	NUM
ijpds-3217	38	32	nm	nm	NOUN
ijpds-3217	38	33	(	(	PUNCT
ijpds-3217	38	34	n	n	CCONJ
ijpds-3217	38	35	-	-	PUNCT
ijpds-3217	38	36	π	π	NOUN
ijpds-3217	38	37	*	*	PROPN
ijpds-3217	38	38	transition	transition	NOUN
ijpds-3217	38	39	)	)	PUNCT
ijpds-3217	38	40	,	,	PUNCT
ijpds-3217	38	41	which	which	PRON
ijpds-3217	38	42	are	be	AUX
ijpds-3217	38	43	characteristic	characteristic	ADJ
ijpds-3217	38	44	of	of	ADP
ijpds-3217	38	45	the	the	DET
ijpds-3217	38	46	protein	protein	NOUN
ijpds-3217	38	47	's	's	PART
ijpds-3217	38	48	structural	structural	ADJ
ijpds-3217	38	49	units	unit	NOUN
ijpds-3217	38	50	[	[	X
ijpds-3217	38	51	16	16	NUM
ijpds-3217	38	52	]	]	PUNCT
ijpds-3217	38	53	.	.	PUNCT
ijpds-3217	39	1	complementing	complement	VERB
ijpds-3217	39	2	spectroscopic	spectroscopic	ADJ
ijpds-3217	39	3	analysis	analysis	NOUN
ijpds-3217	39	4	,	,	PUNCT
ijpds-3217	39	5	which	which	PRON
ijpds-3217	39	6	allows	allow	VERB
ijpds-3217	39	7	obtaining	obtain	VERB
ijpds-3217	39	8	experimental	experimental	ADJ
ijpds-3217	39	9	data	datum	NOUN
ijpds-3217	39	10	on	on	ADP
ijpds-3217	39	11	the	the	DET
ijpds-3217	39	12	binding	bind	VERB
ijpds-3217	39	13	affinity	affinity	NOUN
ijpds-3217	39	14	of	of	ADP
ijpds-3217	39	15	a	a	DET
ijpds-3217	39	16	ligand	ligand	NOUN
ijpds-3217	39	17	with	with	ADP
ijpds-3217	39	18	hsa	hsa	PROPN
ijpds-3217	39	19	and	and	CCONJ
ijpds-3217	39	20	theoretical	theoretical	ADJ
ijpds-3217	39	21	analysis	analysis	NOUN
ijpds-3217	39	22	using	use	VERB
ijpds-3217	39	23	molecular	molecular	ADJ
ijpds-3217	39	24	docking	docking	NOUN
ijpds-3217	39	25	explains	explain	VERB
ijpds-3217	39	26	the	the	DET
ijpds-3217	39	27	binding	bind	VERB
ijpds-3217	39	28	ability	ability	NOUN
ijpds-3217	39	29	at	at	ADP
ijpds-3217	39	30	the	the	DET
ijpds-3217	39	31	molecular	molecular	ADJ
ijpds-3217	39	32	level	level	NOUN
ijpds-3217	39	33	,	,	PUNCT
ijpds-3217	39	34	which	which	PRON
ijpds-3217	39	35	helps	help	VERB
ijpds-3217	39	36	in	in	ADP
ijpds-3217	39	37	understanding	understand	VERB
ijpds-3217	39	38	the	the	DET
ijpds-3217	39	39	experimental	experimental	ADJ
ijpds-3217	39	40	data	datum	NOUN
ijpds-3217	40	1	[	[	X
ijpds-3217	40	2	17	17	NUM
ijpds-3217	40	3	]	]	X
ijpds-3217	40	4	[	[	X
ijpds-3217	40	5	18	18	NUM
ijpds-3217	40	6	]	]	PUNCT
ijpds-3217	40	7	.	.	PUNCT
ijpds-3217	41	1	aiming	aim	VERB
ijpds-3217	41	2	to	to	PART
ijpds-3217	41	3	complement	complement	VERB
ijpds-3217	41	4	the	the	DET
ijpds-3217	41	5	results	result	NOUN
ijpds-3217	41	6	obtained	obtain	VERB
ijpds-3217	41	7	in	in	ADP
ijpds-3217	41	8	the	the	DET
ijpds-3217	41	9	previous	previous	ADJ
ijpds-3217	41	10	work	work	NOUN
ijpds-3217	41	11	[	[	X
ijpds-3217	41	12	1	1	NUM
ijpds-3217	41	13	]	]	PUNCT
ijpds-3217	41	14	,	,	PUNCT
ijpds-3217	41	15	we	we	PRON
ijpds-3217	41	16	studied	study	VERB
ijpds-3217	41	17	the	the	DET
ijpds-3217	41	18	interaction	interaction	NOUN
ijpds-3217	41	19	of	of	ADP
ijpds-3217	41	20	hsa	hsa	PROPN
ijpds-3217	41	21	-	-	PUNCT
ijpds-3217	41	22	hctz	hctz	PROPN
ijpds-3217	41	23	in	in	ADP
ijpds-3217	41	24	the	the	DET
ijpds-3217	41	25	presence	presence	NOUN
ijpds-3217	41	26	and	and	CCONJ
ijpds-3217	41	27	absence	absence	NOUN
ijpds-3217	41	28	of	of	ADP
ijpds-3217	41	29	glu	glu	NOUN
ijpds-3217	41	30	through	through	ADP
ijpds-3217	41	31	the	the	DET
ijpds-3217	41	32	circular	circular	ADJ
ijpds-3217	41	33	dichroism	dichroism	NOUN
ijpds-3217	41	34	technique	technique	NOUN
ijpds-3217	41	35	(	(	PUNCT
ijpds-3217	41	36	far	far	ADV
ijpds-3217	41	37	and	and	CCONJ
ijpds-3217	41	38	near	near	ADP
ijpds-3217	41	39	uv	uv	NOUN
ijpds-3217	41	40	)	)	PUNCT
ijpds-3217	41	41	also	also	ADV
ijpds-3217	41	42	at	at	ADP
ijpds-3217	41	43	37	37	NUM
ijpds-3217	41	44	ºc	ºc	NOUN
ijpds-3217	41	45	.	.	PUNCT
ijpds-3217	42	1	current	current	ADJ
ijpds-3217	42	2	and	and	CCONJ
ijpds-3217	42	3	previous	previous	ADJ
ijpds-3217	42	4	data	datum	NOUN
ijpds-3217	42	5	were	be	AUX
ijpds-3217	42	6	correlated	correlate	VERB
ijpds-3217	42	7	to	to	ADP
ijpds-3217	42	8	theoretical	theoretical	ADJ
ijpds-3217	42	9	analysis	analysis	NOUN
ijpds-3217	42	10	through	through	ADP
ijpds-3217	42	11	molecular	molecular	ADJ
ijpds-3217	42	12	docking	docking	NOUN
ijpds-3217	42	13	simulations	simulation	NOUN
ijpds-3217	42	14	,	,	PUNCT
ijpds-3217	42	15	including	include	VERB
ijpds-3217	42	16	the	the	DET
ijpds-3217	42	17	evaluation	evaluation	NOUN
ijpds-3217	42	18	of	of	ADP
ijpds-3217	42	19	the	the	DET
ijpds-3217	42	20	main	main	ADJ
ijpds-3217	42	21	glu	glu	NOUN
ijpds-3217	42	22	conformation	conformation	NOUN
ijpds-3217	42	23	(	(	PUNCT
ijpds-3217	42	24	open	open	ADJ
ijpds-3217	42	25	or	or	CCONJ
ijpds-3217	42	26	cyclic	cyclic	ADJ
ijpds-3217	42	27	)	)	PUNCT
ijpds-3217	42	28	in	in	ADP
ijpds-3217	42	29	the	the	DET
ijpds-3217	42	30	protein	protein	NOUN
ijpds-3217	42	31	binding	bind	VERB
ijpds-3217	42	32	pocket	pocket	NOUN
ijpds-3217	42	33	.	.	PUNCT
ijpds-3217	43	1	material	material	NOUN
ijpds-3217	43	2	and	and	CCONJ
ijpds-3217	43	3	methods	method	NOUN
ijpds-3217	43	4	materials	material	NOUN
ijpds-3217	43	5	and	and	CCONJ
ijpds-3217	43	6	equipment	equipment	NOUN
ijpds-3217	43	7	hctz	hctz	NOUN
ijpds-3217	43	8	(	(	PUNCT
ijpds-3217	43	9	6	6	NUM
ijpds-3217	43	10	-	-	PUNCT
ijpds-3217	43	11	chloro-3	chloro-3	NUM
ijpds-3217	43	12	-	-	PUNCT
ijpds-3217	43	13	3	3	NUM
ijpds-3217	43	14	,	,	PUNCT
ijpds-3217	43	15	4dihydro2h-1,2,4	4dihydro2h-1,2,4	NUM
ijpds-3217	43	16	-	-	PUNCT
ijpds-3217	43	17	benzothiadiazole-7	benzothiadiazole-7	NOUN
ijpds-3217	43	18	-	-	PUNCT
ijpds-3217	43	19	sulfonamide1,1dioxide	sulfonamide1,1dioxide	NOUN
ijpds-3217	43	20	)	)	PUNCT
ijpds-3217	43	21	,	,	PUNCT
ijpds-3217	43	22	dglucose	dglucose	PROPN
ijpds-3217	43	23	,	,	PUNCT
ijpds-3217	43	24	hsa	hsa	PROPN
ijpds-3217	43	25	,	,	PUNCT
ijpds-3217	43	26	warfarin	warfarin	NOUN
ijpds-3217	43	27	,	,	PUNCT
ijpds-3217	43	28	digitoxin	digitoxin	PROPN
ijpds-3217	43	29	as	as	ADV
ijpds-3217	43	30	well	well	ADV
ijpds-3217	43	31	as	as	ADP
ijpds-3217	43	32	phosphate	phosphate	ADJ
ijpds-3217	43	33	buffer	buffer	NOUN
ijpds-3217	43	34	solution	solution	NOUN
ijpds-3217	43	35	(	(	PUNCT
ijpds-3217	43	36	pbs	pbs	PROPN
ijpds-3217	43	37	)	)	PUNCT
ijpds-3217	43	38	were	be	AUX
ijpds-3217	43	39	purchased	purchase	VERB
ijpds-3217	43	40	from	from	ADP
ijpds-3217	43	41	sigma	sigma	PROPN
ijpds-3217	43	42	-	-	PUNCT
ijpds-3217	43	43	aldrich	aldrich	PROPN
ijpds-3217	43	44	chemical	chemical	PROPN
ijpds-3217	43	45	company	company	NOUN
ijpds-3217	43	46	,	,	PUNCT
ijpds-3217	43	47	st	st	PROPN
ijpds-3217	43	48	.	.	PROPN
ijpds-3217	43	49	louis	louis	PROPN
ijpds-3217	43	50	,	,	PUNCT
ijpds-3217	43	51	usa	usa	PROPN
ijpds-3217	43	52	.	.	PROPN
ijpds-3217	44	1	there	there	PRON
ijpds-3217	44	2	was	be	VERB
ijpds-3217	44	3	no	no	DET
ijpds-3217	44	4	further	further	ADJ
ijpds-3217	44	5	purification	purification	NOUN
ijpds-3217	44	6	.	.	PUNCT
ijpds-3217	45	1	methanol	methanol	NOUN
ijpds-3217	45	2	(	(	PUNCT
ijpds-3217	45	3	spectroscopic	spectroscopic	ADJ
ijpds-3217	45	4	grade	grade	NOUN
ijpds-3217	45	5	)	)	PUNCT
ijpds-3217	45	6	was	be	AUX
ijpds-3217	45	7	obtained	obtain	VERB
ijpds-3217	45	8	from	from	ADP
ijpds-3217	45	9	vetec	vetec	ADJ
ijpds-3217	45	10	,	,	PUNCT
ijpds-3217	45	11	química	química	PROPN
ijpds-3217	45	12	fina	fina	PROPN
ijpds-3217	45	13	ltda	ltda	PROPN
ijpds-3217	45	14	,	,	PUNCT
ijpds-3217	45	15	rio	rio	PROPN
ijpds-3217	45	16	de	de	PROPN
ijpds-3217	45	17	janeiro	janeiro	PROPN
ijpds-3217	45	18	,	,	PUNCT
ijpds-3217	45	19	brazil	brazil	PROPN
ijpds-3217	45	20	.	.	PUNCT
ijpds-3217	46	1	a	a	DET
ijpds-3217	46	2	millipore	millipore	PROPN
ijpds-3217	46	3	milli	milli	PROPN
ijpds-3217	46	4	-	-	PUNCT
ijpds-3217	46	5	q	q	NOUN
ijpds-3217	46	6	system	system	NOUN
ijpds-3217	46	7	(	(	PUNCT
ijpds-3217	46	8	merck	merck	PROPN
ijpds-3217	46	9	kgaa	kgaa	PROPN
ijpds-3217	46	10	,	,	PUNCT
ijpds-3217	46	11	darmstadt	darmstadt	PROPN
ijpds-3217	46	12	,	,	PUNCT
ijpds-3217	46	13	germany	germany	PROPN
ijpds-3217	46	14	)	)	PUNCT
ijpds-3217	46	15	was	be	AUX
ijpds-3217	46	16	used	use	VERB
ijpds-3217	46	17	to	to	PART
ijpds-3217	46	18	obtain	obtain	VERB
ijpds-3217	46	19	purified	purified	ADJ
ijpds-3217	46	20	water.circular	water.circular	ADJ
ijpds-3217	46	21	dichroism	dichroism	NOUN
ijpds-3217	46	22	(	(	PUNCT
ijpds-3217	46	23	cd	cd	PROPN
ijpds-3217	46	24	)	)	PUNCT
ijpds-3217	46	25	spectra	spectra	NOUN
ijpds-3217	46	26	were	be	AUX
ijpds-3217	46	27	measured	measure	VERB
ijpds-3217	46	28	on	on	ADP
ijpds-3217	46	29	a	a	DET
ijpds-3217	46	30	jasco	jasco	PROPN
ijpds-3217	46	31	j-815	j-815	PROPN
ijpds-3217	46	32	spectrophotometer	spectrophotometer	NOUN
ijpds-3217	46	33	coupled	couple	VERB
ijpds-3217	46	34	to	to	ADP
ijpds-3217	46	35	a	a	DET
ijpds-3217	46	36	jasco	jasco	PROPN
ijpds-3217	46	37	pfd425s15f	pfd425s15f	PROPN
ijpds-3217	46	38	thermostatic	thermostatic	ADJ
ijpds-3217	46	39	cuvette	cuvette	NOUN
ijpds-3217	46	40	door	door	NOUN
ijpds-3217	46	41	with	with	ADP
ijpds-3217	46	42	0.1	0.1	NUM
ijpds-3217	46	43	ºc	ºc	NUM
ijpds-3217	46	44	accuracy	accuracy	NOUN
ijpds-3217	46	45	,	,	PUNCT
ijpds-3217	46	46	with	with	ADP
ijpds-3217	46	47	3	3	NUM
ijpds-3217	46	48	channels	channel	NOUN
ijpds-3217	46	49	,	,	PUNCT
ijpds-3217	46	50	one	one	NUM
ijpds-3217	46	51	for	for	ADP
ijpds-3217	46	52	steady	steady	ADJ
ijpds-3217	46	53	-	-	PUNCT
ijpds-3217	46	54	state	state	NOUN
ijpds-3217	46	55	fluorescence	fluorescence	NOUN
ijpds-3217	46	56	,	,	PUNCT
ijpds-3217	46	57	another	another	PRON
ijpds-3217	46	58	for	for	ADP
ijpds-3217	46	59	the	the	DET
ijpds-3217	46	60	cd	cd	PROPN
ijpds-3217	46	61	and	and	CCONJ
ijpds-3217	46	62	the	the	DET
ijpds-3217	46	63	third	third	ADJ
ijpds-3217	46	64	for	for	ADP
ijpds-3217	46	65	the	the	DET
ijpds-3217	46	66	uv	uv	NOUN
ijpds-3217	46	67	-	-	PUNCT
ijpds-3217	46	68	vis	vis	X
ijpds-3217	46	69	(	(	PUNCT
ijpds-3217	46	70	jasco	jasco	PROPN
ijpds-3217	46	71	easton	easton	PROPN
ijpds-3217	46	72	,	,	PUNCT
ijpds-3217	46	73	md	md	PROPN
ijpds-3217	46	74	,	,	PUNCT
ijpds-3217	46	75	usa	usa	PROPN
ijpds-3217	46	76	)	)	PUNCT
ijpds-3217	47	1	[	[	X
ijpds-3217	47	2	19	19	NUM
ijpds-3217	47	3	]	]	PUNCT
ijpds-3217	47	4	.	.	PUNCT
ijpds-3217	48	1	circular	circular	ADJ
ijpds-3217	48	2	dichroism	dichroism	NOUN
ijpds-3217	48	3	(	(	PUNCT
ijpds-3217	48	4	cd	cd	NOUN
ijpds-3217	48	5	)	)	PUNCT
ijpds-3217	48	6	measurements	measurement	VERB
ijpds-3217	48	7	the	the	DET
ijpds-3217	48	8	circular	circular	ADJ
ijpds-3217	48	9	dichroism	dichroism	NOUN
ijpds-3217	48	10	(	(	PUNCT
ijpds-3217	48	11	cd	cd	PROPN
ijpds-3217	48	12	)	)	PUNCT
ijpds-3217	48	13	analysis	analysis	NOUN
ijpds-3217	48	14	was	be	AUX
ijpds-3217	48	15	performed	perform	VERB
ijpds-3217	48	16	using	use	VERB
ijpds-3217	48	17	3.0	3.0	NUM
ijpds-3217	48	18	ml	ml	NOUN
ijpds-3217	48	19	of	of	ADP
ijpds-3217	48	20	hsa	hsa	PROPN
ijpds-3217	48	21	solution	solution	NOUN
ijpds-3217	48	22	(	(	PUNCT
ijpds-3217	48	23	10	10	NUM
ijpds-3217	48	24	-	-	SYM
ijpds-3217	48	25	6	6	NUM
ijpds-3217	48	26	m	m	NOUN
ijpds-3217	48	27	,	,	PUNCT
ijpds-3217	48	28	in	in	ADP
ijpds-3217	48	29	pbs	pbs	PROPN
ijpds-3217	48	30	,	,	PUNCT
ijpds-3217	48	31	ph=7.4	ph=7.4	PROPN
ijpds-3217	48	32	)	)	PUNCT
ijpds-3217	48	33	in	in	ADP
ijpds-3217	48	34	the	the	DET
ijpds-3217	48	35	absence	absence	NOUN
ijpds-3217	48	36	and	and	CCONJ
ijpds-3217	48	37	presence	presence	NOUN
ijpds-3217	48	38	of	of	ADP
ijpds-3217	48	39	hctz	hctz	PROPN
ijpds-3217	48	40	(	(	PUNCT
ijpds-3217	48	41	1:12	1:12	NUM
ijpds-3217	48	42	,	,	PUNCT
ijpds-3217	48	43	1:24	1:24	NUM
ijpds-3217	48	44	,	,	PUNCT
ijpds-3217	48	45	and	and	CCONJ
ijpds-3217	48	46	1:48	1:48	NUM
ijpds-3217	48	47	hsa	hsa	PROPN
ijpds-3217	48	48	-	-	PUNCT
ijpds-3217	48	49	hctz	hctz	PROPN
ijpds-3217	48	50	solution	solution	NOUN
ijpds-3217	48	51	,	,	PUNCT
ijpds-3217	48	52	in	in	ADP
ijpds-3217	48	53	pbs	pbs	PROPN
ijpds-3217	48	54	)	)	PUNCT
ijpds-3217	48	55	.	.	PUNCT
ijpds-3217	49	1	the	the	DET
ijpds-3217	49	2	effect	effect	NOUN
ijpds-3217	49	3	of	of	ADP
ijpds-3217	49	4	the	the	DET
ijpds-3217	49	5	glu	glu	NOUN
ijpds-3217	49	6	concentration	concentration	NOUN
ijpds-3217	49	7	on	on	ADP
ijpds-3217	49	8	hsa	hsa	PROPN
ijpds-3217	49	9	-	-	PUNCT
ijpds-3217	49	10	hctz	hctz	PROPN
ijpds-3217	49	11	cd	cd	PROPN
ijpds-3217	49	12	spectra	spectra	NOUN
ijpds-3217	49	13	were	be	AUX
ijpds-3217	49	14	evaluated	evaluate	VERB
ijpds-3217	49	15	in	in	ADP
ijpds-3217	49	16	solutions	solution	NOUN
ijpds-3217	49	17	containing	contain	VERB
ijpds-3217	49	18	80	80	NUM
ijpds-3217	49	19	mg	mg	PROPN
ijpds-3217	49	20	/	/	SYM
ijpds-3217	49	21	dl	dl	PROPN
ijpds-3217	49	22	and	and	CCONJ
ijpds-3217	49	23	320	320	NUM
ijpds-3217	49	24	mg	mg	PROPN
ijpds-3217	49	25	/	/	SYM
ijpds-3217	49	26	dl	dl	PROPN
ijpds-3217	49	27	glu	glu	PROPN
ijpds-3217	49	28	.	.	PUNCT
ijpds-3217	50	1	all	all	DET
ijpds-3217	50	2	cd	cd	PROPN
ijpds-3217	50	3	spectra	spectra	NOUN
ijpds-3217	50	4	were	be	AUX
ijpds-3217	50	5	recorded	record	VERB
ijpds-3217	50	6	to	to	ADP
ijpds-3217	50	7	both	both	PRON
ijpds-3217	50	8	far	far	ADV
ijpds-3217	50	9	-	-	PUNCT
ijpds-3217	50	10	uv	uv	NOUN
ijpds-3217	50	11	(	(	PUNCT
ijpds-3217	50	12	200	200	NUM
ijpds-3217	50	13	-	-	SYM
ijpds-3217	50	14	250	250	NUM
ijpds-3217	50	15	nm	nm	NOUN
ijpds-3217	50	16	,	,	PUNCT
ijpds-3217	50	17	for	for	ADP
ijpds-3217	50	18	secondary	secondary	ADJ
ijpds-3217	50	19	structure	structure	NOUN
ijpds-3217	50	20	)	)	PUNCT
ijpds-3217	50	21	and	and	CCONJ
ijpds-3217	50	22	near	near	ADP
ijpds-3217	50	23	-	-	PUNCT
ijpds-3217	50	24	uv	uv	NOUN
ijpds-3217	50	25	(	(	PUNCT
ijpds-3217	50	26	260	260	NUM
ijpds-3217	50	27	-	-	SYM
ijpds-3217	50	28	320	320	NUM
ijpds-3217	50	29	nm	nm	NOUN
ijpds-3217	50	30	,	,	PUNCT
ijpds-3217	50	31	for	for	ADP
ijpds-3217	50	32	tertiary	tertiary	ADJ
ijpds-3217	50	33	structure	structure	NOUN
ijpds-3217	50	34	)	)	PUNCT
ijpds-3217	51	1	[	[	X
ijpds-3217	51	2	20	20	NUM
ijpds-3217	51	3	,	,	PUNCT
ijpds-3217	51	4	21	21	NUM
ijpds-3217	51	5	]	]	PUNCT
ijpds-3217	51	6	.	.	PUNCT
ijpds-3217	52	1	the	the	DET
ijpds-3217	52	2	intensity	intensity	NOUN
ijpds-3217	52	3	of	of	ADP
ijpds-3217	52	4	the	the	DET
ijpds-3217	52	5	signals	signal	NOUN
ijpds-3217	52	6	in	in	ADP
ijpds-3217	52	7	the	the	DET
ijpds-3217	52	8	cd	cd	PROPN
ijpds-3217	52	9	spectra	spectra	NOUN
ijpds-3217	52	10	was	be	AUX
ijpds-3217	52	11	expressed	express	VERB
ijpds-3217	52	12	as	as	ADP
ijpds-3217	52	13	molar	molar	ADJ
ijpds-3217	52	14	residue	residue	NOUN
ijpds-3217	52	15	ellipticity	ellipticity	NOUN
ijpds-3217	52	16	(	(	PUNCT
ijpds-3217	52	17	mre	mre	NOUN
ijpds-3217	52	18	,	,	PUNCT
ijpds-3217	52	19	in	in	ADP
ijpds-3217	52	20	deg	deg	PROPN
ijpds-3217	52	21	cm2	cm2	PROPN
ijpds-3217	52	22	dmol-1	dmol-1	PROPN
ijpds-3217	52	23	)	)	PUNCT
ijpds-3217	52	24	,	,	PUNCT
ijpds-3217	52	25	defined	define	VERB
ijpds-3217	52	26	according	accord	VERB
ijpds-3217	52	27	to	to	ADP
ijpds-3217	52	28	the	the	DET
ijpds-3217	52	29	following	follow	VERB
ijpds-3217	52	30	equation	equation	NOUN
ijpds-3217	52	31	[	[	X
ijpds-3217	52	32	21	21	NUM
ijpds-3217	52	33	]	]	PUNCT
ijpds-3217	52	34	.	.	PUNCT
ijpds-3217	53	1	,	,	PUNCT
ijpds-3217	53	2	(	(	PUNCT
ijpds-3217	53	3	3	3	X
ijpds-3217	53	4	)	)	PUNCT
ijpds-3217	53	5	where	where	SCONJ
ijpds-3217	53	6	θ	θ	NOUN
ijpds-3217	53	7	,	,	PUNCT
ijpds-3217	53	8	n	n	CCONJ
ijpds-3217	53	9	,	,	PUNCT
ijpds-3217	53	10	l	l	NOUN
ijpds-3217	53	11	,	,	PUNCT
ijpds-3217	53	12	and	and	CCONJ
ijpds-3217	53	13	cp	cp	PRON
ijpds-3217	53	14	are	be	AUX
ijpds-3217	53	15	the	the	DET
ijpds-3217	53	16	observed	observed	ADJ
ijpds-3217	53	17	ellipticity	ellipticity	NOUN
ijpds-3217	53	18	(	(	PUNCT
ijpds-3217	53	19	mdeg	mdeg	ADJ
ijpds-3217	53	20	)	)	PUNCT
ijpds-3217	53	21	,	,	PUNCT
ijpds-3217	53	22	a	a	DET
ijpds-3217	53	23	number	number	NOUN
ijpds-3217	53	24	of	of	ADP
ijpds-3217	53	25	amino	amino	NOUN
ijpds-3217	53	26	acid	acid	NOUN
ijpds-3217	53	27	residues	residue	NOUN
ijpds-3217	53	28	(	(	PUNCT
ijpds-3217	53	29	585	585	NUM
ijpds-3217	53	30	to	to	PART
ijpds-3217	53	31	hsa	hsa	PROPN
ijpds-3217	53	32	)	)	PUNCT
ijpds-3217	54	1	[	[	X
ijpds-3217	54	2	22	22	NUM
ijpds-3217	54	3	]	]	PUNCT
ijpds-3217	54	4	,	,	PUNCT
ijpds-3217	54	5	optical	optical	ADJ
ijpds-3217	54	6	cuvette	cuvette	NOUN
ijpds-3217	54	7	length	length	NOUN
ijpds-3217	54	8	(	(	PUNCT
ijpds-3217	54	9	1.0	1.0	NUM
ijpds-3217	54	10	cm	cm	NOUN
ijpds-3217	54	11	)	)	PUNCT
ijpds-3217	54	12	,	,	PUNCT
ijpds-3217	54	13	and	and	CCONJ
ijpds-3217	54	14	molar	molar	ADJ
ijpds-3217	54	15	hsa	hsa	NOUN
ijpds-3217	54	16	concentration	concentration	NOUN
ijpds-3217	54	17	(	(	PUNCT
ijpds-3217	54	18	10	10	NUM
ijpds-3217	54	19	-	-	SYM
ijpds-3217	54	20	6	6	NUM
ijpds-3217	54	21	m	m	NOUN
ijpds-3217	54	22	)	)	PUNCT
ijpds-3217	54	23	,	,	PUNCT
ijpds-3217	54	24	respectively	respectively	ADV
ijpds-3217	54	25	.	.	PUNCT
ijpds-3217	55	1	in	in	ADP
ijpds-3217	55	2	order	order	NOUN
ijpds-3217	55	3	to	to	PART
ijpds-3217	55	4	calculate	calculate	VERB
ijpds-3217	55	5	the	the	DET
ijpds-3217	55	6	quantitative	quantitative	ADJ
ijpds-3217	55	7	loss	loss	NOUN
ijpds-3217	55	8	of	of	ADP
ijpds-3217	55	9	the	the	DET
ijpds-3217	55	10	helical	helical	ADJ
ijpds-3217	55	11	structure	structure	NOUN
ijpds-3217	55	12	of	of	ADP
ijpds-3217	55	13	the	the	DET
ijpds-3217	55	14	protein	protein	NOUN
ijpds-3217	55	15	due	due	ADJ
ijpds-3217	55	16	to	to	ADP
ijpds-3217	55	17	hctz	hctz	PROPN
ijpds-3217	55	18	binding	binding	NOUN
ijpds-3217	55	19	,	,	PUNCT
ijpds-3217	55	20	the	the	DET
ijpds-3217	55	21	mre	mre	PROPN
ijpds-3217	55	22	values	value	NOUN
ijpds-3217	55	23	at	at	ADP
ijpds-3217	55	24	208	208	NUM
ijpds-3217	55	25	and	and	CCONJ
ijpds-3217	55	26	222	222	NUM
ijpds-3217	55	27	nm	nm	NOUN
ijpds-3217	55	28	were	be	AUX
ijpds-3217	55	29	obtained	obtain	VERB
ijpds-3217	55	30	according	accord	VERB
ijpds-3217	55	31	to	to	ADP
ijpds-3217	55	32	the	the	DET
ijpds-3217	55	33	equations	equation	NOUN
ijpds-3217	55	34	[	[	X
ijpds-3217	55	35	23	23	NUM
ijpds-3217	55	36	]	]	PUNCT
ijpds-3217	55	37	.	.	PUNCT
ijpds-3217	56	1	,	,	PUNCT
ijpds-3217	56	2	(	(	PUNCT
ijpds-3217	56	3	4	4	NUM
ijpds-3217	56	4	)	)	PUNCT
ijpds-3217	56	5	,	,	PUNCT
ijpds-3217	56	6	(	(	PUNCT
ijpds-3217	56	7	5	5	X
ijpds-3217	56	8	)	)	PUNCT
ijpds-3217	56	9	where	where	SCONJ
ijpds-3217	56	10	𝑀𝑅𝐸208	𝑀𝑅𝐸208	NOUN
ijpds-3217	56	11	and	and	CCONJ
ijpds-3217	56	12	𝑀𝑅𝐸222	𝑀𝑅𝐸222	PROPN
ijpds-3217	56	13	are	be	AUX
ijpds-3217	56	14	the	the	DET
ijpds-3217	56	15	significant	significant	ADJ
ijpds-3217	56	16	ellipticity	ellipticity	NOUN
ijpds-3217	56	17	molar	molar	ADJ
ijpds-3217	56	18	residues	residue	NOUN
ijpds-3217	56	19	(	(	PUNCT
ijpds-3217	56	20	deg.cm2	deg.cm2	NOUN
ijpds-3217	56	21	/	/	SYM
ijpds-3217	56	22	dmol	dmol	PROPN
ijpds-3217	56	23	)	)	PUNCT
ijpds-3217	56	24	at	at	ADP
ijpds-3217	56	25	208	208	NUM
ijpds-3217	56	26	nm	nm	NOUN
ijpds-3217	56	27	and	and	CCONJ
ijpds-3217	56	28	222	222	NUM
ijpds-3217	56	29	nm	nm	NOUN
ijpds-3217	56	30	,	,	PUNCT
ijpds-3217	56	31	respectively	respectively	ADV
ijpds-3217	56	32	.	.	PUNCT
ijpds-3217	57	1	molecular	molecular	ADJ
ijpds-3217	57	2	docking	docking	NOUN
ijpds-3217	57	3	simulations	simulation	VERB
ijpds-3217	57	4	the	the	DET
ijpds-3217	57	5	crystallographic	crystallographic	ADJ
ijpds-3217	57	6	structure	structure	NOUN
ijpds-3217	57	7	of	of	ADP
ijpds-3217	57	8	hsa	hsa	PROPN
ijpds-3217	57	9	was	be	AUX
ijpds-3217	57	10	obtained	obtain	VERB
ijpds-3217	57	11	from	from	ADP
ijpds-3217	57	12	protein	protein	NOUN
ijpds-3217	57	13	data	data	PROPN
ijpds-3217	57	14	bank	bank	PROPN
ijpds-3217	57	15	(	(	PUNCT
ijpds-3217	57	16	pdb	pdb	PROPN
ijpds-3217	57	17	)	)	PUNCT
ijpds-3217	57	18	with	with	ADP
ijpds-3217	57	19	access	access	NOUN
ijpds-3217	57	20	code	code	NOUN
ijpds-3217	57	21	1n5u	1n5u	NUM
ijpds-3217	58	1	[	[	X
ijpds-3217	58	2	22l	22l	NOUN
ijpds-3217	58	3	]	]	PUNCT
ijpds-3217	58	4	.	.	PUNCT
ijpds-3217	59	1	the	the	DET
ijpds-3217	59	2	chemical	chemical	ADJ
ijpds-3217	59	3	structure	structure	NOUN
ijpds-3217	59	4	of	of	ADP
ijpds-3217	59	5	hctz	hctz	PROPN
ijpds-3217	59	6	and	and	CCONJ
ijpds-3217	59	7	glu	glu	NOUN
ijpds-3217	59	8	(	(	PUNCT
ijpds-3217	59	9	open	open	ADJ
ijpds-3217	59	10	and	and	CCONJ
ijpds-3217	59	11	cyclic	cyclic	ADJ
ijpds-3217	59	12	forms	form	NOUN
ijpds-3217	59	13	)	)	PUNCT
ijpds-3217	59	14	were	be	AUX
ijpds-3217	59	15	built	build	VERB
ijpds-3217	59	16	and	and	CCONJ
ijpds-3217	59	17	minimized	minimize	VERB
ijpds-3217	59	18	in	in	ADP
ijpds-3217	59	19	terms	term	NOUN
ijpds-3217	59	20	of	of	ADP
ijpds-3217	59	21	energy	energy	NOUN
ijpds-3217	59	22	using	use	VERB
ijpds-3217	59	23	the	the	DET
ijpds-3217	59	24	functional	functional	ADJ
ijpds-3217	59	25	density	density	NOUN
ijpds-3217	59	26	theory	theory	NOUN
ijpds-3217	59	27	(	(	PUNCT
ijpds-3217	59	28	dft	dft	PROPN
ijpds-3217	59	29	)	)	PUNCT
ijpds-3217	59	30	by	by	ADP
ijpds-3217	59	31	becke-3	becke-3	PROPN
ijpds-3217	59	32	-	-	PROPN
ijpds-3217	59	33	lee	lee	PROPN
ijpds-3217	59	34	yang	yang	PROPN
ijpds-3217	59	35	parr	parr	PROPN
ijpds-3217	59	36	(	(	PUNCT
ijpds-3217	59	37	b3lyp	b3lyp	NUM
ijpds-3217	59	38	)	)	PUNCT
ijpds-3217	59	39	with	with	ADP
ijpds-3217	59	40	the	the	DET
ijpds-3217	59	41	standard	standard	ADJ
ijpds-3217	59	42	base	base	NOUN
ijpds-3217	59	43	set	set	VERB
ijpds-3217	59	44	631	631	NUM
ijpds-3217	59	45	g	g	NOUN
ijpds-3217	59	46	*	*	PUNCT
ijpds-3217	59	47	,	,	PUNCT
ijpds-3217	59	48	available	available	ADJ
ijpds-3217	59	49	in	in	ADP
ijpds-3217	59	50	the	the	DET
ijpds-3217	59	51	spartan'14	spartan'14	PROPN
ijpds-3217	59	52	software	software	NOUN
ijpds-3217	59	53	(	(	PUNCT
ijpds-3217	59	54	wavefunction	wavefunction	NOUN
ijpds-3217	59	55	,	,	PUNCT
ijpds-3217	59	56	inc	inc	PROPN
ijpds-3217	59	57	.	.	PUNCT
ijpds-3217	59	58	)	)	PUNCT
ijpds-3217	60	1	[	[	X
ijpds-3217	60	2	24	24	NUM
ijpds-3217	60	3	]	]	PUNCT
ijpds-3217	60	4	.	.	PUNCT
ijpds-3217	61	1	figure	figure	VERB
ijpds-3217	61	2	1	1	NUM
ijpds-3217	61	3	far	far	ADV
ijpds-3217	61	4	-	-	PUNCT
ijpds-3217	61	5	uv	uv	NOUN
ijpds-3217	61	6	cd	cd	NOUN
ijpds-3217	61	7	spectra	spectra	NOUN
ijpds-3217	61	8	for	for	ADP
ijpds-3217	61	9	hsa	hsa	PROPN
ijpds-3217	61	10	-	-	PUNCT
ijpds-3217	61	11	hctz	hctz	PROPN
ijpds-3217	61	12	(	(	PUNCT
ijpds-3217	61	13	a	a	NOUN
ijpds-3217	61	14	)	)	PUNCT
ijpds-3217	61	15	and	and	CCONJ
ijpds-3217	61	16	hsa	hsa	PROPN
ijpds-3217	61	17	-	-	PUNCT
ijpds-3217	61	18	glucose	glucose	NOUN
ijpds-3217	61	19	(	(	PUNCT
ijpds-3217	61	20	b	b	NOUN
ijpds-3217	61	21	)	)	PUNCT
ijpds-3217	61	22	at	at	ADP
ijpds-3217	61	23	37	37	NUM
ijpds-3217	61	24	ºc	ºc	NOUN
ijpds-3217	61	25	,	,	PUNCT
ijpds-3217	61	26	respectively	respectively	ADV
ijpds-3217	61	27	.	.	PUNCT
ijpds-3217	62	1	near	near	ADP
ijpds-3217	62	2	-	-	PUNCT
ijpds-3217	62	3	uv	uv	NOUN
ijpds-3217	62	4	cd	cd	NOUN
ijpds-3217	62	5	spectra	spectra	NOUN
ijpds-3217	62	6	for	for	ADP
ijpds-3217	62	7	hsahctz	hsahctz	PROPN
ijpds-3217	62	8	(	(	PUNCT
ijpds-3217	62	9	c	c	NOUN
ijpds-3217	62	10	)	)	PUNCT
ijpds-3217	62	11	and	and	CCONJ
ijpds-3217	62	12	hsa	hsa	NOUN
ijpds-3217	62	13	-	-	PUNCT
ijpds-3217	62	14	glucose	glucose	NOUN
ijpds-3217	62	15	(	(	PUNCT
ijpds-3217	62	16	d	d	NOUN
ijpds-3217	62	17	)	)	PUNCT
ijpds-3217	62	18	at	at	ADP
ijpds-3217	62	19	37	37	NUM
ijpds-3217	62	20	ºc	ºc	NOUN
ijpds-3217	62	21	,	,	PUNCT
ijpds-3217	62	22	respectively	respectively	ADV
ijpds-3217	62	23	.	.	PUNCT
ijpds-3217	63	1	[	[	X
ijpds-3217	63	2	hsa]=	hsa]=	NOUN
ijpds-3217	63	3	1.00	1.00	NUM
ijpds-3217	63	4	×	×	NOUN
ijpds-3217	63	5	10	10	NUM
ijpds-3217	63	6	-	-	SYM
ijpds-3217	63	7	6	6	NUM
ijpds-3217	63	8	m	m	NOUN
ijpds-3217	63	9	and	and	CCONJ
ijpds-3217	63	10	[	[	X
ijpds-3217	63	11	glucose	glucose	X
ijpds-3217	63	12	]	]	X
ijpds-3217	63	13	=	=	SYM
ijpds-3217	63	14	80	80	NUM
ijpds-3217	63	15	and	and	CCONJ
ijpds-3217	63	16	320	320	NUM
ijpds-3217	63	17	mg	mg	PROPN
ijpds-3217	63	18	/	/	SYM
ijpds-3217	63	19	dl	dl	PROPN
ijpds-3217	63	20	soares	soar	VERB
ijpds-3217	63	21	et	et	PROPN
ijpds-3217	63	22	al	al	PROPN
ijpds-3217	63	23	hsa	hsa	PROPN
ijpds-3217	63	24	-	-	PUNCT
ijpds-3217	63	25	hctz	hctz	ADJ
ijpds-3217	63	26	interactions	interaction	NOUN
ijpds-3217	63	27	based	base	VERB
ijpds-3217	63	28	on	on	ADP
ijpds-3217	63	29	glucose	glucose	NOUN
ijpds-3217	63	30	concentrations	concentration	NOUN
ijpds-3217	63	31	vol	vol	NOUN
ijpds-3217	63	32	1	1	NUM
ijpds-3217	63	33	|	|	NOUN
ijpds-3217	63	34	issue	issue	NOUN
ijpds-3217	63	35	2	2	NUM
ijpds-3217	64	1	|	|	ADV
ijpds-3217	64	2	jul	jul	PROPN
ijpds-3217	64	3	sep	sep	PROPN
ijpds-3217	64	4	2022	2022	NUM
ijpds-3217	64	5	indian	indian	PROPN
ijpds-3217	64	6	j	j	PROPN
ijpds-3217	64	7	pharm	pharm	PROPN
ijpds-3217	64	8	drug	drug	PROPN
ijpds-3217	64	9	studies	study	NOUN
ijpds-3217	64	10	|	|	ADV
ijpds-3217	64	11	58	58	NUM
ijpds-3217	64	12	figure	figure	NOUN
ijpds-3217	64	13	2	2	NUM
ijpds-3217	64	14	far	far	ADV
ijpds-3217	64	15	-	-	PUNCT
ijpds-3217	64	16	uv	uv	NOUN
ijpds-3217	64	17	cd	cd	NOUN
ijpds-3217	64	18	spectra	spectra	NOUN
ijpds-3217	64	19	for	for	ADP
ijpds-3217	64	20	hsa	hsa	PROPN
ijpds-3217	64	21	-	-	PUNCT
ijpds-3217	64	22	hctz	hctz	PROPN
ijpds-3217	64	23	in	in	ADP
ijpds-3217	64	24	the	the	DET
ijpds-3217	64	25	presence	presence	NOUN
ijpds-3217	64	26	of	of	ADP
ijpds-3217	64	27	glucose	glucose	NOUN
ijpds-3217	64	28	,	,	PUNCT
ijpds-3217	64	29	80	80	NUM
ijpds-3217	64	30	mg	mg	PROPN
ijpds-3217	64	31	/	/	SYM
ijpds-3217	64	32	dl	dl	PROPN
ijpds-3217	64	33	(	(	PUNCT
ijpds-3217	64	34	a	a	NOUN
ijpds-3217	64	35	)	)	PUNCT
ijpds-3217	64	36	and	and	CCONJ
ijpds-3217	64	37	320	320	NUM
ijpds-3217	64	38	mg	mg	PROPN
ijpds-3217	64	39	/	/	SYM
ijpds-3217	64	40	dl	dl	PROPN
ijpds-3217	64	41	(	(	PUNCT
ijpds-3217	64	42	b	b	NOUN
ijpds-3217	64	43	)	)	PUNCT
ijpds-3217	64	44	at	at	ADP
ijpds-3217	64	45	37	37	NUM
ijpds-3217	64	46	ºc	ºc	NUM
ijpds-3217	64	47	.	.	PROPN
ijpds-3217	65	1	near	near	ADP
ijpds-3217	65	2	-	-	PUNCT
ijpds-3217	65	3	uv	uv	NOUN
ijpds-3217	65	4	cd	cd	NOUN
ijpds-3217	65	5	spectra	spectra	NOUN
ijpds-3217	65	6	for	for	ADP
ijpds-3217	65	7	hsa	hsa	PROPN
ijpds-3217	65	8	-	-	PUNCT
ijpds-3217	65	9	hctz	hctz	PROPN
ijpds-3217	65	10	in	in	ADP
ijpds-3217	65	11	the	the	DET
ijpds-3217	65	12	presence	presence	NOUN
ijpds-3217	65	13	of	of	ADP
ijpds-3217	65	14	glucose	glucose	NOUN
ijpds-3217	65	15	,	,	PUNCT
ijpds-3217	65	16	80	80	NUM
ijpds-3217	65	17	mg	mg	PROPN
ijpds-3217	65	18	/	/	SYM
ijpds-3217	65	19	dl	dl	PROPN
ijpds-3217	65	20	(	(	PUNCT
ijpds-3217	65	21	c	c	NOUN
ijpds-3217	65	22	)	)	PUNCT
ijpds-3217	65	23	and	and	CCONJ
ijpds-3217	65	24	320	320	NUM
ijpds-3217	65	25	mg	mg	PROPN
ijpds-3217	65	26	/	/	SYM
ijpds-3217	65	27	dl	dl	PROPN
ijpds-3217	65	28	(	(	PUNCT
ijpds-3217	65	29	d	d	NOUN
ijpds-3217	65	30	)	)	PUNCT
ijpds-3217	65	31	at	at	ADP
ijpds-3217	65	32	37	37	NUM
ijpds-3217	65	33	ºc	ºc	NOUN
ijpds-3217	65	34	.	.	PUNCT
ijpds-3217	66	1	[	[	X
ijpds-3217	66	2	hsa	hsa	X
ijpds-3217	66	3	]	]	X
ijpds-3217	66	4	=	=	SYM
ijpds-3217	66	5	1.00	1.00	NUM
ijpds-3217	66	6	×	×	NOUN
ijpds-3217	66	7	10	10	NUM
ijpds-3217	66	8	-	-	SYM
ijpds-3217	66	9	6	6	NUM
ijpds-3217	66	10	m	m	NOUN
ijpds-3217	66	11	and	and	CCONJ
ijpds-3217	67	1	[	[	X
ijpds-3217	67	2	glucose	glucose	X
ijpds-3217	67	3	]	]	X
ijpds-3217	67	4	=	=	SYM
ijpds-3217	67	5	80	80	NUM
ijpds-3217	67	6	and	and	CCONJ
ijpds-3217	67	7	320	320	NUM
ijpds-3217	67	8	mg	mg	PROPN
ijpds-3217	67	9	/	/	SYM
ijpds-3217	67	10	dl	dl	PROPN
ijpds-3217	67	11	.	.	NOUN
ijpds-3217	67	12	molecular	molecular	ADJ
ijpds-3217	67	13	docking	docking	NOUN
ijpds-3217	67	14	studies	study	NOUN
ijpds-3217	67	15	were	be	AUX
ijpds-3217	67	16	performed	perform	VERB
ijpds-3217	67	17	using	use	VERB
ijpds-3217	67	18	gold	gold	NOUN
ijpds-3217	67	19	5.7	5.7	NUM
ijpds-3217	67	20	software	software	NOUN
ijpds-3217	67	21	(	(	PUNCT
ijpds-3217	67	22	cambridge	cambridge	PROPN
ijpds-3217	67	23	crystallographic	crystallographic	PROPN
ijpds-3217	67	24	data	data	PROPN
ijpds-3217	67	25	centre	centre	PROPN
ijpds-3217	67	26	ccdc	ccdc	PROPN
ijpds-3217	67	27	)	)	PUNCT
ijpds-3217	68	1	[	[	X
ijpds-3217	68	2	25	25	NUM
ijpds-3217	68	3	]	]	PUNCT
ijpds-3217	68	4	.	.	PUNCT
ijpds-3217	69	1	hydrogen	hydrogen	NOUN
ijpds-3217	69	2	atoms	atom	NOUN
ijpds-3217	69	3	were	be	AUX
ijpds-3217	69	4	added	add	VERB
ijpds-3217	69	5	to	to	ADP
ijpds-3217	69	6	the	the	DET
ijpds-3217	69	7	albumin	albumin	ADJ
ijpds-3217	69	8	structure	structure	NOUN
ijpds-3217	69	9	according	accord	VERB
ijpds-3217	69	10	to	to	ADP
ijpds-3217	69	11	the	the	DET
ijpds-3217	69	12	data	datum	NOUN
ijpds-3217	69	13	inferred	infer	VERB
ijpds-3217	69	14	by	by	ADP
ijpds-3217	69	15	the	the	DET
ijpds-3217	69	16	program	program	NOUN
ijpds-3217	69	17	on	on	ADP
ijpds-3217	69	18	the	the	DET
ijpds-3217	69	19	ionization	ionization	NOUN
ijpds-3217	69	20	and	and	CCONJ
ijpds-3217	69	21	tautomeric	tautomeric	ADJ
ijpds-3217	69	22	states	state	NOUN
ijpds-3217	69	23	.	.	PUNCT
ijpds-3217	70	1	it	it	PRON
ijpds-3217	70	2	is	be	AUX
ijpds-3217	70	3	known	know	VERB
ijpds-3217	70	4	that	that	SCONJ
ijpds-3217	70	5	hsa	hsa	PROPN
ijpds-3217	70	6	presents	present	VERB
ijpds-3217	70	7	three	three	NUM
ijpds-3217	70	8	main	main	ADJ
ijpds-3217	70	9	binding	bind	VERB
ijpds-3217	70	10	pockets	pocket	NOUN
ijpds-3217	70	11	for	for	ADP
ijpds-3217	70	12	different	different	ADJ
ijpds-3217	70	13	ligands	ligand	NOUN
ijpds-3217	70	14	(	(	PUNCT
ijpds-3217	70	15	sites	site	NOUN
ijpds-3217	70	16	i	i	PRON
ijpds-3217	70	17	,	,	PUNCT
ijpds-3217	70	18	ii	ii	PROPN
ijpds-3217	70	19	,	,	PUNCT
ijpds-3217	70	20	and	and	CCONJ
ijpds-3217	70	21	iii	iii	NOUN
ijpds-3217	70	22	,	,	PUNCT
ijpds-3217	70	23	which	which	PRON
ijpds-3217	70	24	are	be	AUX
ijpds-3217	70	25	identified	identify	VERB
ijpds-3217	70	26	through	through	ADP
ijpds-3217	70	27	trp214	trp214	PROPN
ijpds-3217	70	28	,	,	PUNCT
ijpds-3217	70	29	tyr-411	tyr-411	ADJ
ijpds-3217	70	30	,	,	PUNCT
ijpds-3217	70	31	and	and	CCONJ
ijpds-3217	70	32	tyr-161	tyr-161	ADJ
ijpds-3217	70	33	residues	residue	NOUN
ijpds-3217	70	34	[	[	X
ijpds-3217	70	35	23	23	NUM
ijpds-3217	70	36	]	]	PUNCT
ijpds-3217	71	1	[	[	X
ijpds-3217	71	2	26	26	NUM
ijpds-3217	71	3	]	]	X
ijpds-3217	71	4	[	[	X
ijpds-3217	71	5	27	27	NUM
ijpds-3217	71	6	]	]	PUNCT
ijpds-3217	71	7	.	.	PUNCT
ijpds-3217	72	1	in	in	ADP
ijpds-3217	72	2	order	order	NOUN
ijpds-3217	72	3	to	to	PART
ijpds-3217	72	4	identify	identify	VERB
ijpds-3217	72	5	the	the	DET
ijpds-3217	72	6	main	main	ADJ
ijpds-3217	72	7	amino	amino	NOUN
ijpds-3217	72	8	acid	acid	NOUN
ijpds-3217	72	9	residues	residue	NOUN
ijpds-3217	72	10	involved	involve	VERB
ijpds-3217	72	11	in	in	ADP
ijpds-3217	72	12	the	the	DET
ijpds-3217	72	13	interaction	interaction	NOUN
ijpds-3217	72	14	hsa	hsa	PROPN
ijpds-3217	72	15	-	-	PUNCT
ijpds-3217	72	16	hctz	hctz	NOUN
ijpds-3217	72	17	,	,	PUNCT
ijpds-3217	72	18	as	as	ADV
ijpds-3217	72	19	well	well	ADV
ijpds-3217	72	20	as	as	ADP
ijpds-3217	72	21	to	to	PART
ijpds-3217	72	22	evaluate	evaluate	VERB
ijpds-3217	72	23	the	the	DET
ijpds-3217	72	24	main	main	ADJ
ijpds-3217	72	25	possible	possible	ADJ
ijpds-3217	72	26	binding	bind	VERB
ijpds-3217	72	27	site	site	NOUN
ijpds-3217	72	28	,	,	PUNCT
ijpds-3217	72	29	a	a	DET
ijpds-3217	72	30	spherical	spherical	ADJ
ijpds-3217	72	31	10	10	NUM
ijpds-3217	72	32	å	å	PROPN
ijpds-3217	72	33	radius	radius	NOUN
ijpds-3217	72	34	around	around	ADP
ijpds-3217	72	35	trp-214	trp-214	ADJ
ijpds-3217	72	36	,	,	PUNCT
ijpds-3217	72	37	tyr-411	tyr-411	ADJ
ijpds-3217	72	38	,	,	PUNCT
ijpds-3217	72	39	and	and	CCONJ
ijpds-3217	72	40	tyr-161	tyr-161	ADJ
ijpds-3217	72	41	residues	residue	NOUN
ijpds-3217	72	42	was	be	AUX
ijpds-3217	72	43	defined	define	VERB
ijpds-3217	72	44	,	,	PUNCT
ijpds-3217	72	45	and	and	CCONJ
ijpds-3217	72	46	molecular	molecular	ADJ
ijpds-3217	72	47	docking	docking	NOUN
ijpds-3217	72	48	simulations	simulation	NOUN
ijpds-3217	72	49	were	be	AUX
ijpds-3217	72	50	carried	carry	VERB
ijpds-3217	72	51	out	out	ADP
ijpds-3217	72	52	[	[	X
ijpds-3217	72	53	28	28	NUM
ijpds-3217	72	54	]	]	PUNCT
ijpds-3217	72	55	.	.	PUNCT
ijpds-3217	73	1	furthermore	furthermore	ADV
ijpds-3217	73	2	,	,	PUNCT
ijpds-3217	73	3	the	the	DET
ijpds-3217	73	4	theoretical	theoretical	ADJ
ijpds-3217	73	5	evaluation	evaluation	NOUN
ijpds-3217	73	6	of	of	ADP
ijpds-3217	73	7	the	the	DET
ijpds-3217	73	8	glu	glu	NOUN
ijpds-3217	73	9	effect	effect	NOUN
ijpds-3217	73	10	(	(	PUNCT
ijpds-3217	73	11	in	in	ADP
ijpds-3217	73	12	the	the	DET
ijpds-3217	73	13	open	open	ADJ
ijpds-3217	73	14	and	and	CCONJ
ijpds-3217	73	15	cyclic	cyclic	ADJ
ijpds-3217	73	16	forms	form	NOUN
ijpds-3217	73	17	)	)	PUNCT
ijpds-3217	73	18	on	on	ADP
ijpds-3217	73	19	hsa	hsa	PROPN
ijpds-3217	73	20	-	-	ADJ
ijpds-3217	73	21	hctz	hctz	ADJ
ijpds-3217	73	22	binding	binding	NOUN
ijpds-3217	73	23	was	be	AUX
ijpds-3217	73	24	simulated	simulate	VERB
ijpds-3217	73	25	,	,	PUNCT
ijpds-3217	73	26	as	as	ADV
ijpds-3217	73	27	well	well	ADV
ijpds-3217	73	28	as	as	ADP
ijpds-3217	73	29	the	the	DET
ijpds-3217	73	30	docking	docking	NOUN
ijpds-3217	73	31	calculations	calculation	NOUN
ijpds-3217	73	32	were	be	AUX
ijpds-3217	73	33	carried	carry	VERB
ijpds-3217	73	34	out	out	ADP
ijpds-3217	73	35	to	to	ADP
ijpds-3217	73	36	hctz	hctz	PROPN
ijpds-3217	73	37	and	and	CCONJ
ijpds-3217	73	38	glu	glu	PROPN
ijpds-3217	73	39	(	(	PUNCT
ijpds-3217	73	40	in	in	ADP
ijpds-3217	73	41	both	both	DET
ijpds-3217	73	42	forms	form	NOUN
ijpds-3217	73	43	)	)	PUNCT
ijpds-3217	73	44	at	at	ADP
ijpds-3217	73	45	the	the	DET
ijpds-3217	73	46	same	same	ADJ
ijpds-3217	73	47	time	time	NOUN
ijpds-3217	73	48	under	under	ADP
ijpds-3217	73	49	the	the	DET
ijpds-3217	73	50	same	same	ADJ
ijpds-3217	73	51	spherical	spherical	ADJ
ijpds-3217	73	52	radius	radius	NOUN
ijpds-3217	73	53	described	describe	VERB
ijpds-3217	73	54	above	above	ADV
ijpds-3217	73	55	.	.	PUNCT
ijpds-3217	74	1	a	a	DET
ijpds-3217	74	2	more	more	ADV
ijpds-3217	74	3	positive	positive	ADJ
ijpds-3217	74	4	docking	docking	NOUN
ijpds-3217	74	5	score	score	NOUN
ijpds-3217	74	6	value	value	NOUN
ijpds-3217	74	7	indicates	indicate	VERB
ijpds-3217	74	8	better	well	ADJ
ijpds-3217	74	9	interaction	interaction	NOUN
ijpds-3217	74	10	,	,	PUNCT
ijpds-3217	74	11	due	due	ADP
ijpds-3217	74	12	to	to	ADP
ijpds-3217	74	13	the	the	DET
ijpds-3217	74	14	negative	negative	ADJ
ijpds-3217	74	15	sum	sum	NOUN
ijpds-3217	74	16	of	of	ADP
ijpds-3217	74	17	a	a	DET
ijpds-3217	74	18	series	series	NOUN
ijpds-3217	74	19	of	of	ADP
ijpds-3217	74	20	energy	energy	NOUN
ijpds-3217	74	21	terms	term	NOUN
ijpds-3217	74	22	involved	involve	VERB
ijpds-3217	74	23	in	in	ADP
ijpds-3217	74	24	the	the	DET
ijpds-3217	74	25	protein	protein	NOUN
ijpds-3217	74	26	binding	bind	VERB
ijpds-3217	74	27	interaction	interaction	NOUN
ijpds-3217	74	28	process	process	NOUN
ijpds-3217	74	29	.	.	PUNCT
ijpds-3217	75	1	the	the	DET
ijpds-3217	75	2	number	number	NOUN
ijpds-3217	75	3	of	of	ADP
ijpds-3217	75	4	genetic	genetic	ADJ
ijpds-3217	75	5	operations	operation	NOUN
ijpds-3217	75	6	(	(	PUNCT
ijpds-3217	75	7	crossing	crossing	NOUN
ijpds-3217	75	8	,	,	PUNCT
ijpds-3217	75	9	migration	migration	NOUN
ijpds-3217	75	10	,	,	PUNCT
ijpds-3217	75	11	and	and	CCONJ
ijpds-3217	75	12	mutation	mutation	NOUN
ijpds-3217	75	13	)	)	PUNCT
ijpds-3217	75	14	in	in	ADP
ijpds-3217	75	15	each	each	DET
ijpds-3217	75	16	docking	docking	NOUN
ijpds-3217	75	17	run	run	NOUN
ijpds-3217	75	18	was	be	AUX
ijpds-3217	75	19	defined	define	VERB
ijpds-3217	75	20	as	as	ADP
ijpds-3217	75	21	100,000	100,000	NUM
ijpds-3217	75	22	.	.	PUNCT
ijpds-3217	76	1	the	the	DET
ijpds-3217	76	2	scoring	scoring	NOUN
ijpds-3217	76	3	function	function	NOUN
ijpds-3217	76	4	used	use	VERB
ijpds-3217	76	5	was	be	AUX
ijpds-3217	76	6	“	"	PUNCT
ijpds-3217	76	7	chemplp	chemplp	NOUN
ijpds-3217	76	8	”	"	PUNCT
ijpds-3217	76	9	,	,	PUNCT
ijpds-3217	76	10	which	which	PRON
ijpds-3217	76	11	is	be	AUX
ijpds-3217	76	12	the	the	DET
ijpds-3217	76	13	standard	standard	ADJ
ijpds-3217	76	14	function	function	NOUN
ijpds-3217	76	15	of	of	ADP
ijpds-3217	76	16	the	the	DET
ijpds-3217	76	17	gold	gold	ADJ
ijpds-3217	76	18	5.7	5.7	NUM
ijpds-3217	76	19	software	software	NOUN
ijpds-3217	76	20	.	.	PUNCT
ijpds-3217	77	1	the	the	DET
ijpds-3217	77	2	figure	figure	NOUN
ijpds-3217	77	3	of	of	ADP
ijpds-3217	77	4	the	the	DET
ijpds-3217	77	5	best	good	ADJ
ijpds-3217	77	6	docking	docking	NOUN
ijpds-3217	77	7	pose	pose	VERB
ijpds-3217	77	8	for	for	SCONJ
ijpds-3217	77	9	each	each	DET
ijpds-3217	77	10	case	case	NOUN
ijpds-3217	77	11	was	be	AUX
ijpds-3217	77	12	generated	generate	VERB
ijpds-3217	77	13	with	with	ADP
ijpds-3217	77	14	pymol	pymol	PROPN
ijpds-3217	77	15	delano	delano	PROPN
ijpds-3217	77	16	scientific	scientific	PROPN
ijpds-3217	77	17	llc	llc	PROPN
ijpds-3217	77	18	software	software	NOUN
ijpds-3217	78	1	[	[	X
ijpds-3217	78	2	29	29	NUM
ijpds-3217	78	3	]	]	PUNCT
ijpds-3217	78	4	.	.	PUNCT
ijpds-3217	79	1	results	result	NOUN
ijpds-3217	79	2	and	and	CCONJ
ijpds-3217	79	3	discussion	discussion	NOUN
ijpds-3217	79	4	three	three	NUM
ijpds-3217	79	5	different	different	ADJ
ijpds-3217	79	6	cases	case	NOUN
ijpds-3217	79	7	were	be	AUX
ijpds-3217	79	8	analyzed	analyze	VERB
ijpds-3217	79	9	by	by	ADP
ijpds-3217	79	10	cd	cd	PROPN
ijpds-3217	79	11	measurements	measurement	NOUN
ijpds-3217	79	12	:	:	PUNCT
ijpds-3217	79	13	(	(	PUNCT
ijpds-3217	79	14	i	i	NOUN
ijpds-3217	79	15	)	)	PUNCT
ijpds-3217	79	16	evaluation	evaluation	NOUN
ijpds-3217	79	17	of	of	ADP
ijpds-3217	79	18	the	the	DET
ijpds-3217	79	19	albumin	albumin	ADJ
ijpds-3217	79	20	structure	structure	NOUN
ijpds-3217	79	21	upon	upon	SCONJ
ijpds-3217	79	22	hctz	hctz	PROPN
ijpds-3217	79	23	binding	binding	NOUN
ijpds-3217	79	24	,	,	PUNCT
ijpds-3217	79	25	(	(	PUNCT
ijpds-3217	79	26	ii	ii	NOUN
ijpds-3217	79	27	)	)	PUNCT
ijpds-3217	79	28	evaluation	evaluation	NOUN
ijpds-3217	79	29	of	of	ADP
ijpds-3217	79	30	the	the	DET
ijpds-3217	79	31	albumin	albumin	ADJ
ijpds-3217	79	32	structure	structure	NOUN
ijpds-3217	79	33	upon	upon	SCONJ
ijpds-3217	79	34	glu	glu	NOUN
ijpds-3217	79	35	binding	binding	NOUN
ijpds-3217	79	36	,	,	PUNCT
ijpds-3217	79	37	and	and	CCONJ
ijpds-3217	79	38	(	(	PUNCT
ijpds-3217	79	39	iii	iii	X
ijpds-3217	79	40	)	)	PUNCT
ijpds-3217	79	41	glu	glu	NOUN
ijpds-3217	79	42	effect	effect	NOUN
ijpds-3217	79	43	on	on	ADP
ijpds-3217	79	44	hsa	hsa	PROPN
ijpds-3217	79	45	-	-	PUNCT
ijpds-3217	79	46	hctz	hctz	PROPN
ijpds-3217	79	47	cd	cd	PROPN
ijpds-3217	79	48	spectra	spectra	PROPN
ijpds-3217	79	49	.	.	PUNCT
ijpds-3217	80	1	figure	figure	VERB
ijpds-3217	80	2	1	1	NUM
ijpds-3217	80	3	a	a	DET
ijpds-3217	80	4	shows	show	NOUN
ijpds-3217	80	5	that	that	SCONJ
ijpds-3217	80	6	in	in	ADP
ijpds-3217	80	7	the	the	DET
ijpds-3217	80	8	far	far	ADV
ijpds-3217	80	9	-	-	PUNCT
ijpds-3217	80	10	uv	uv	NOUN
ijpds-3217	80	11	,	,	PUNCT
ijpds-3217	80	12	hctz	hctz	PROPN
ijpds-3217	80	13	caused	cause	VERB
ijpds-3217	80	14	little	little	ADJ
ijpds-3217	80	15	perturbation	perturbation	NOUN
ijpds-3217	80	16	on	on	ADP
ijpds-3217	80	17	the	the	DET
ijpds-3217	80	18	secondary	secondary	ADJ
ijpds-3217	80	19	structure	structure	NOUN
ijpds-3217	80	20	of	of	ADP
ijpds-3217	80	21	albumin	albumin	NOUN
ijpds-3217	80	22	for	for	ADP
ijpds-3217	80	23	the	the	DET
ijpds-3217	80	24	three	three	NUM
ijpds-3217	80	25	investigated	investigate	VERB
ijpds-3217	80	26	hsa	hsa	PROPN
ijpds-3217	80	27	:	:	PUNCT
ijpds-3217	80	28	hctz	hctz	PROPN
ijpds-3217	80	29	ratios	ratio	NOUN
ijpds-3217	80	30	(	(	PUNCT
ijpds-3217	80	31	1:12	1:12	NUM
ijpds-3217	80	32	,	,	PUNCT
ijpds-3217	80	33	1:24	1:24	NUM
ijpds-3217	80	34	,	,	PUNCT
ijpds-3217	80	35	and	and	CCONJ
ijpds-3217	80	36	1:48	1:48	NUM
ijpds-3217	80	37	)	)	PUNCT
ijpds-3217	80	38	.	.	PUNCT
ijpds-3217	81	1	the	the	DET
ijpds-3217	81	2	content	content	NOUN
ijpds-3217	81	3	of	of	ADP
ijpds-3217	81	4	α	α	NOUN
ijpds-3217	81	5	-	-	NOUN
ijpds-3217	81	6	helix	helix	NOUN
ijpds-3217	81	7	(	(	PUNCT
ijpds-3217	81	8	%	%	INTJ
ijpds-3217	81	9	)	)	PUNCT
ijpds-3217	81	10	at	at	ADP
ijpds-3217	81	11	208	208	NUM
ijpds-3217	81	12	and	and	CCONJ
ijpds-3217	81	13	222	222	NUM
ijpds-3217	81	14	nm	nm	ADJ
ijpds-3217	81	15	(	(	PUNCT
ijpds-3217	81	16	table	table	NOUN
ijpds-3217	81	17	1	1	NUM
ijpds-3217	81	18	)	)	PUNCT
ijpds-3217	81	19	confirms	confirm	VERB
ijpds-3217	81	20	that	that	SCONJ
ijpds-3217	81	21	hctz	hctz	PROPN
ijpds-3217	81	22	caused	cause	VERB
ijpds-3217	81	23	little	little	ADJ
ijpds-3217	81	24	perturbation	perturbation	NOUN
ijpds-3217	81	25	in	in	ADP
ijpds-3217	81	26	the	the	DET
ijpds-3217	81	27	secondary	secondary	ADJ
ijpds-3217	81	28	structure	structure	NOUN
ijpds-3217	81	29	of	of	ADP
ijpds-3217	81	30	albumin	albumin	NOUN
ijpds-3217	81	31	,	,	PUNCT
ijpds-3217	81	32	since	since	ADV
ijpds-3217	81	33	,	,	PUNCT
ijpds-3217	81	34	for	for	ADP
ijpds-3217	81	35	the	the	DET
ijpds-3217	81	36	1:48	1:48	NUM
ijpds-3217	81	37	ratio	ratio	NOUN
ijpds-3217	81	38	,	,	PUNCT
ijpds-3217	81	39	the	the	DET
ijpds-3217	81	40	maximum	maximum	ADJ
ijpds-3217	81	41	reductions	reduction	NOUN
ijpds-3217	81	42	of	of	ADP
ijpds-3217	81	43	3.47	3.47	NUM
ijpds-3217	81	44	%	%	NOUN
ijpds-3217	81	45	and	and	CCONJ
ijpds-3217	81	46	3.79	3.79	NUM
ijpds-3217	81	47	%	%	NOUN
ijpds-3217	81	48	at	at	ADP
ijpds-3217	81	49	208	208	NUM
ijpds-3217	81	50	and	and	CCONJ
ijpds-3217	81	51	222	222	NUM
ijpds-3217	81	52	nm	nm	NOUN
ijpds-3217	81	53	,	,	PUNCT
ijpds-3217	81	54	respectively	respectively	ADV
ijpds-3217	81	55	,	,	PUNCT
ijpds-3217	81	56	were	be	AUX
ijpds-3217	81	57	found	find	VERB
ijpds-3217	81	58	[	[	X
ijpds-3217	81	59	30	30	NUM
ijpds-3217	81	60	]	]	PUNCT
ijpds-3217	81	61	.	.	PUNCT
ijpds-3217	82	1	in	in	ADP
ijpds-3217	82	2	the	the	DET
ijpds-3217	82	3	absence	absence	NOUN
ijpds-3217	82	4	of	of	ADP
ijpds-3217	82	5	hctz	hctz	PROPN
ijpds-3217	82	6	,	,	PUNCT
ijpds-3217	82	7	glu	glu	NOUN
ijpds-3217	82	8	at	at	ADP
ijpds-3217	82	9	normoglycemic	normoglycemic	ADJ
ijpds-3217	82	10	concentration	concentration	NOUN
ijpds-3217	82	11	also	also	ADV
ijpds-3217	82	12	caused	cause	VERB
ijpds-3217	82	13	a	a	DET
ijpds-3217	82	14	weak	weak	ADJ
ijpds-3217	82	15	disturbance	disturbance	NOUN
ijpds-3217	82	16	,	,	PUNCT
ijpds-3217	82	17	with	with	ADP
ijpds-3217	82	18	a	a	DET
ijpds-3217	82	19	maximum	maximum	ADJ
ijpds-3217	82	20	reduction	reduction	NOUN
ijpds-3217	82	21	of	of	ADP
ijpds-3217	82	22	3.45	3.45	NUM
ijpds-3217	82	23	%	%	NOUN
ijpds-3217	82	24	at	at	ADP
ijpds-3217	82	25	222	222	NUM
ijpds-3217	82	26	nm	nm	NOUN
ijpds-3217	82	27	.	.	PUNCT
ijpds-3217	83	1	but	but	CCONJ
ijpds-3217	83	2	a	a	DET
ijpds-3217	83	3	relatively	relatively	ADV
ijpds-3217	83	4	strong	strong	ADJ
ijpds-3217	83	5	disturbance	disturbance	NOUN
ijpds-3217	83	6	in	in	ADP
ijpds-3217	83	7	the	the	DET
ijpds-3217	83	8	secondary	secondary	ADJ
ijpds-3217	83	9	structure	structure	NOUN
ijpds-3217	83	10	of	of	ADP
ijpds-3217	83	11	albumin	albumin	NOUN
ijpds-3217	83	12	was	be	AUX
ijpds-3217	83	13	observed	observe	VERB
ijpds-3217	83	14	for	for	ADP
ijpds-3217	83	15	glu	glu	NOUN
ijpds-3217	83	16	in	in	ADP
ijpds-3217	83	17	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	83	18	concentration	concentration	NOUN
ijpds-3217	83	19	,	,	PUNCT
ijpds-3217	83	20	with	with	ADP
ijpds-3217	83	21	a	a	DET
ijpds-3217	83	22	maximum	maximum	ADJ
ijpds-3217	83	23	reduction	reduction	NOUN
ijpds-3217	83	24	of	of	ADP
ijpds-3217	83	25	12.66	12.66	NUM
ijpds-3217	83	26	%	%	NOUN
ijpds-3217	83	27	at	at	ADP
ijpds-3217	83	28	222	222	NUM
ijpds-3217	83	29	nm	nm	NOUN
ijpds-3217	83	30	(	(	PUNCT
ijpds-3217	83	31	figure	figure	NOUN
ijpds-3217	83	32	1b	1b	NUM
ijpds-3217	83	33	and	and	CCONJ
ijpds-3217	83	34	table	table	NOUN
ijpds-3217	83	35	2	2	NUM
ijpds-3217	83	36	)	)	PUNCT
ijpds-3217	83	37	.	.	PUNCT
ijpds-3217	84	1	thus	thus	ADV
ijpds-3217	84	2	,	,	PUNCT
ijpds-3217	84	3	high	high	ADJ
ijpds-3217	84	4	concentrations	concentration	NOUN
ijpds-3217	84	5	of	of	ADP
ijpds-3217	84	6	glu	glu	NOUN
ijpds-3217	84	7	in	in	ADP
ijpds-3217	84	8	diabetic	diabetic	ADJ
ijpds-3217	84	9	patients	patient	NOUN
ijpds-3217	84	10	can	can	AUX
ijpds-3217	84	11	significantly	significantly	ADV
ijpds-3217	84	12	disrupt	disrupt	VERB
ijpds-3217	84	13	the	the	DET
ijpds-3217	84	14	secondary	secondary	ADJ
ijpds-3217	84	15	structure	structure	NOUN
ijpds-3217	84	16	of	of	ADP
ijpds-3217	84	17	albumin	albumin	NOUN
ijpds-3217	84	18	,	,	PUNCT
ijpds-3217	84	19	possibly	possibly	ADV
ijpds-3217	84	20	destabilizing	destabilize	VERB
ijpds-3217	84	21	the	the	DET
ijpds-3217	84	22	interaction	interaction	NOUN
ijpds-3217	84	23	forces	force	NOUN
ijpds-3217	84	24	(	(	PUNCT
ijpds-3217	84	25	e.g.	e.g.	ADV
ijpds-3217	84	26	,	,	PUNCT
ijpds-3217	84	27	hydrogen	hydrogen	NOUN
ijpds-3217	84	28	bonding	bonding	NOUN
ijpds-3217	84	29	)	)	PUNCT
ijpds-3217	84	30	responsible	responsible	ADJ
ijpds-3217	84	31	for	for	ADP
ijpds-3217	84	32	protein	protein	NOUN
ijpds-3217	84	33	stability	stability	NOUN
ijpds-3217	84	34	[	[	X
ijpds-3217	84	35	31	31	NUM
ijpds-3217	84	36	]	]	PUNCT
ijpds-3217	84	37	.	.	PUNCT
ijpds-3217	85	1	soares	soares	PROPN
ijpds-3217	85	2	et	et	PROPN
ijpds-3217	85	3	al	al	PROPN
ijpds-3217	85	4	hsa	hsa	PROPN
ijpds-3217	85	5	-	-	PUNCT
ijpds-3217	85	6	hctz	hctz	ADJ
ijpds-3217	85	7	interactions	interaction	NOUN
ijpds-3217	85	8	based	base	VERB
ijpds-3217	85	9	on	on	ADP
ijpds-3217	85	10	glucose	glucose	NOUN
ijpds-3217	85	11	concentrations	concentration	NOUN
ijpds-3217	85	12	vol	vol	NOUN
ijpds-3217	85	13	1	1	NUM
ijpds-3217	85	14	|	|	NOUN
ijpds-3217	85	15	issue	issue	NOUN
ijpds-3217	85	16	2	2	NUM
ijpds-3217	86	1	|	|	ADV
ijpds-3217	86	2	jul	jul	PROPN
ijpds-3217	86	3	sep	sep	PROPN
ijpds-3217	86	4	2022	2022	NUM
ijpds-3217	86	5	indian	indian	PROPN
ijpds-3217	86	6	j	j	PROPN
ijpds-3217	86	7	pharm	pharm	PROPN
ijpds-3217	86	8	drug	drug	PROPN
ijpds-3217	86	9	studies	study	NOUN
ijpds-3217	86	10	|	|	ADV
ijpds-3217	86	11	59	59	NUM
ijpds-3217	86	12	table	table	NOUN
ijpds-3217	86	13	1	1	NUM
ijpds-3217	86	14	α	α	NOUN
ijpds-3217	86	15	-	-	PUNCT
ijpds-3217	86	16	helix	helix	ADJ
ijpds-3217	86	17	%	%	NOUN
ijpds-3217	86	18	for	for	ADP
ijpds-3217	86	19	hsa	hsa	NOUN
ijpds-3217	86	20	without	without	ADP
ijpds-3217	86	21	and	and	CCONJ
ijpds-3217	86	22	in	in	ADP
ijpds-3217	86	23	the	the	DET
ijpds-3217	86	24	presence	presence	NOUN
ijpds-3217	86	25	of	of	ADP
ijpds-3217	86	26	hctz	hctz	PROPN
ijpds-3217	86	27	in	in	ADP
ijpds-3217	86	28	pbs	pbs	PROPN
ijpds-3217	86	29	solution	solution	NOUN
ijpds-3217	86	30	at	at	ADP
ijpds-3217	86	31	37	37	NUM
ijpds-3217	86	32	ºc	ºc	PROPN
ijpds-3217	86	33	ratio	ratio	PROPN
ijpds-3217	86	34	hsahctz	hsahctz	PROPN
ijpds-3217	86	35	hsahctz	hsahctz	PROPN
ijpds-3217	86	36	(	(	PUNCT
ijpds-3217	86	37	208	208	NUM
ijpds-3217	86	38	nm	nm	NOUN
ijpds-3217	86	39	)	)	PUNCT
ijpds-3217	86	40	hsahctz	hsahctz	PROPN
ijpds-3217	86	41	(	(	PUNCT
ijpds-3217	86	42	222	222	NUM
ijpds-3217	86	43	nm	nm	NOUN
ijpds-3217	86	44	)	)	PUNCT
ijpds-3217	86	45	reduction	reduction	NOUN
ijpds-3217	86	46	%	%	NOUN
ijpds-3217	86	47	(	(	PUNCT
ijpds-3217	86	48	208	208	NUM
ijpds-3217	86	49	nm	nm	NOUN
ijpds-3217	86	50	)	)	PUNCT
ijpds-3217	86	51	reduction	reduction	NOUN
ijpds-3217	86	52	%	%	NOUN
ijpds-3217	86	53	(	(	PUNCT
ijpds-3217	86	54	222	222	NUM
ijpds-3217	86	55	nm	nm	NOUN
ijpds-3217	86	56	)	)	PUNCT
ijpds-3217	86	57	1:0	1:0	NOUN
ijpds-3217	86	58	54.50	54.50	NUM
ijpds-3217	86	59	51.49	51.49	NUM
ijpds-3217	86	60	1:12	1:12	NUM
ijpds-3217	86	61	54.04	54.04	NUM
ijpds-3217	86	62	50.40	50.40	NUM
ijpds-3217	86	63	0.84	0.84	NUM
ijpds-3217	86	64	2.11	2.11	NUM
ijpds-3217	86	65	1:24	1:24	NUM
ijpds-3217	86	66	52.92	52.92	NUM
ijpds-3217	86	67	50.27	50.27	NUM
ijpds-3217	86	68	2.90	2.90	NUM
ijpds-3217	86	69	2.37	2.37	NUM
ijpds-3217	86	70	1:48	1:48	NUM
ijpds-3217	86	71	52.61	52.61	NUM
ijpds-3217	86	72	49.54	49.54	NUM
ijpds-3217	86	73	3.47	3.47	NUM
ijpds-3217	86	74	3.79	3.79	NUM
ijpds-3217	86	75	in	in	ADP
ijpds-3217	86	76	addition	addition	NOUN
ijpds-3217	86	77	,	,	PUNCT
ijpds-3217	86	78	the	the	DET
ijpds-3217	86	79	near	near	ADJ
ijpds-3217	86	80	-	-	PUNCT
ijpds-3217	86	81	uv	uv	NOUN
ijpds-3217	86	82	cd	cd	NOUN
ijpds-3217	86	83	spectra	spectra	NOUN
ijpds-3217	86	84	for	for	ADP
ijpds-3217	86	85	hsahctz	hsahctz	PROPN
ijpds-3217	86	86	reveal	reveal	VERB
ijpds-3217	86	87	weak	weak	ADJ
ijpds-3217	86	88	signals	signal	NOUN
ijpds-3217	86	89	in	in	ADP
ijpds-3217	86	90	the	the	DET
ijpds-3217	86	91	range	range	NOUN
ijpds-3217	86	92	290	290	NUM
ijpds-3217	86	93	-	-	SYM
ijpds-3217	86	94	305	305	NUM
ijpds-3217	86	95	nm	nm	NOUN
ijpds-3217	86	96	,	,	PUNCT
ijpds-3217	86	97	which	which	PRON
ijpds-3217	86	98	associates	associate	VERB
ijpds-3217	86	99	with	with	ADP
ijpds-3217	86	100	the	the	DET
ijpds-3217	86	101	amino	amino	NOUN
ijpds-3217	86	102	acid	acid	NOUN
ijpds-3217	86	103	residue	residue	NOUN
ijpds-3217	86	104	trp-214	trp-214	NOUN
ijpds-3217	86	105	(	(	PUNCT
ijpds-3217	86	106	figure	figure	NOUN
ijpds-3217	86	107	1c	1c	NOUN
ijpds-3217	86	108	)	)	PUNCT
ijpds-3217	86	109	.	.	PUNCT
ijpds-3217	87	1	this	this	PRON
ijpds-3217	87	2	indicates	indicate	VERB
ijpds-3217	87	3	that	that	SCONJ
ijpds-3217	87	4	the	the	DET
ijpds-3217	87	5	binding	binding	NOUN
ijpds-3217	87	6	of	of	ADP
ijpds-3217	87	7	hctz	hctz	NOUN
ijpds-3217	87	8	to	to	ADP
ijpds-3217	87	9	the	the	DET
ijpds-3217	87	10	subdomain	subdomain	NOUN
ijpds-3217	87	11	iia	iia	NOUN
ijpds-3217	87	12	,	,	PUNCT
ijpds-3217	87	13	which	which	PRON
ijpds-3217	87	14	is	be	AUX
ijpds-3217	87	15	located	locate	VERB
ijpds-3217	87	16	at	at	ADP
ijpds-3217	87	17	the	the	DET
ijpds-3217	87	18	primary	primary	ADJ
ijpds-3217	87	19	site	site	NOUN
ijpds-3217	87	20	for	for	ADP
ijpds-3217	87	21	this	this	DET
ijpds-3217	87	22	drug	drug	NOUN
ijpds-3217	87	23	in	in	ADP
ijpds-3217	87	24	hsa	hsa	PROPN
ijpds-3217	87	25	[	[	X
ijpds-3217	87	26	1	1	NUM
ijpds-3217	87	27	]	]	PUNCT
ijpds-3217	87	28	,	,	PUNCT
ijpds-3217	87	29	does	do	AUX
ijpds-3217	87	30	not	not	PART
ijpds-3217	87	31	significantly	significantly	ADV
ijpds-3217	87	32	perturb	perturb	VERB
ijpds-3217	87	33	the	the	DET
ijpds-3217	87	34	protein	protein	NOUN
ijpds-3217	87	35	tertiary	tertiary	ADJ
ijpds-3217	87	36	structure	structure	NOUN
ijpds-3217	87	37	,	,	PUNCT
ijpds-3217	87	38	as	as	SCONJ
ijpds-3217	87	39	demonstrated	demonstrate	VERB
ijpds-3217	87	40	by	by	ADP
ijpds-3217	87	41	the	the	DET
ijpds-3217	87	42	slight	slight	ADJ
ijpds-3217	87	43	increase	increase	NOUN
ijpds-3217	87	44	in	in	ADP
ijpds-3217	87	45	cd	cd	NOUN
ijpds-3217	87	46	signals	signal	NOUN
ijpds-3217	87	47	.	.	PUNCT
ijpds-3217	88	1	these	these	DET
ijpds-3217	88	2	results	result	NOUN
ijpds-3217	88	3	suggest	suggest	VERB
ijpds-3217	88	4	that	that	SCONJ
ijpds-3217	88	5	there	there	PRON
ijpds-3217	88	6	is	be	VERB
ijpds-3217	88	7	an	an	DET
ijpds-3217	88	8	increase	increase	NOUN
ijpds-3217	88	9	in	in	ADP
ijpds-3217	88	10	hydrophilicity	hydrophilicity	NOUN
ijpds-3217	88	11	in	in	ADP
ijpds-3217	88	12	the	the	DET
ijpds-3217	88	13	trp-214	trp-214	PROPN
ijpds-3217	88	14	environment	environment	PROPN
ijpds-3217	88	15	,	,	PUNCT
ijpds-3217	88	16	the	the	DET
ijpds-3217	88	17	same	same	ADJ
ijpds-3217	88	18	trend	trend	NOUN
ijpds-3217	88	19	observed	observe	VERB
ijpds-3217	88	20	in	in	ADP
ijpds-3217	88	21	the	the	DET
ijpds-3217	88	22	results	result	NOUN
ijpds-3217	88	23	of	of	ADP
ijpds-3217	88	24	steady	steady	ADJ
ijpds-3217	88	25	-	-	PUNCT
ijpds-3217	88	26	state	state	NOUN
ijpds-3217	88	27	fluorescence	fluorescence	NOUN
ijpds-3217	88	28	quenching	quenching	NOUN
ijpds-3217	88	29	[	[	X
ijpds-3217	88	30	32	32	NUM
ijpds-3217	88	31	]	]	PUNCT
ijpds-3217	88	32	.	.	PUNCT
ijpds-3217	89	1	verifying	verify	VERB
ijpds-3217	89	2	the	the	DET
ijpds-3217	89	3	effect	effect	NOUN
ijpds-3217	89	4	of	of	ADP
ijpds-3217	89	5	glu	glu	NOUN
ijpds-3217	89	6	in	in	ADP
ijpds-3217	89	7	pure	pure	ADJ
ijpds-3217	89	8	hsa	hsa	NOUN
ijpds-3217	89	9	solution	solution	NOUN
ijpds-3217	89	10	in	in	ADP
ijpds-3217	89	11	figure	figure	NOUN
ijpds-3217	89	12	1d	1d	NUM
ijpds-3217	89	13	,	,	PUNCT
ijpds-3217	89	14	we	we	PRON
ijpds-3217	89	15	observed	observe	VERB
ijpds-3217	89	16	that	that	SCONJ
ijpds-3217	89	17	the	the	DET
ijpds-3217	89	18	cd	cd	NOUN
ijpds-3217	89	19	signals	signal	NOUN
ijpds-3217	89	20	in	in	ADP
ijpds-3217	89	21	the	the	DET
ijpds-3217	89	22	trp-214	trp-214	ADJ
ijpds-3217	89	23	region	region	PROPN
ijpds-3217	89	24	show	show	VERB
ijpds-3217	89	25	a	a	DET
ijpds-3217	89	26	significant	significant	ADJ
ijpds-3217	89	27	decrease	decrease	NOUN
ijpds-3217	89	28	,	,	PUNCT
ijpds-3217	89	29	mainly	mainly	ADV
ijpds-3217	89	30	in	in	ADP
ijpds-3217	89	31	the	the	DET
ijpds-3217	89	32	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	89	33	condition	condition	NOUN
ijpds-3217	89	34	,	,	PUNCT
ijpds-3217	89	35	indicating	indicate	VERB
ijpds-3217	89	36	an	an	DET
ijpds-3217	89	37	increase	increase	NOUN
ijpds-3217	89	38	in	in	ADP
ijpds-3217	89	39	the	the	DET
ijpds-3217	89	40	tertiary	tertiary	ADJ
ijpds-3217	89	41	structure	structure	NOUN
ijpds-3217	89	42	of	of	ADP
ijpds-3217	89	43	the	the	DET
ijpds-3217	89	44	protein	protein	NOUN
ijpds-3217	89	45	by	by	ADP
ijpds-3217	89	46	an	an	DET
ijpds-3217	89	47	increase	increase	NOUN
ijpds-3217	89	48	in	in	ADP
ijpds-3217	89	49	hydrophobicity	hydrophobicity	NOUN
ijpds-3217	89	50	.	.	PUNCT
ijpds-3217	90	1	this	this	PRON
ijpds-3217	90	2	may	may	AUX
ijpds-3217	90	3	be	be	AUX
ijpds-3217	90	4	due	due	ADJ
ijpds-3217	90	5	to	to	ADP
ijpds-3217	90	6	a	a	DET
ijpds-3217	90	7	collapse	collapse	NOUN
ijpds-3217	90	8	transition	transition	NOUN
ijpds-3217	90	9	which	which	PRON
ijpds-3217	90	10	can	can	AUX
ijpds-3217	90	11	directly	directly	ADV
ijpds-3217	90	12	impact	impact	VERB
ijpds-3217	90	13	the	the	DET
ijpds-3217	90	14	capacity	capacity	NOUN
ijpds-3217	90	15	of	of	ADP
ijpds-3217	90	16	ligands	ligand	NOUN
ijpds-3217	90	17	binding	bind	VERB
ijpds-3217	90	18	to	to	ADP
ijpds-3217	90	19	hsa	hsa	PROPN
ijpds-3217	90	20	[	[	X
ijpds-3217	90	21	33	33	NUM
ijpds-3217	90	22	]	]	PUNCT
ijpds-3217	90	23	.	.	PUNCT
ijpds-3217	91	1	these	these	DET
ijpds-3217	91	2	results	result	NOUN
ijpds-3217	91	3	are	be	AUX
ijpds-3217	91	4	relevant	relevant	ADJ
ijpds-3217	91	5	since	since	SCONJ
ijpds-3217	91	6	they	they	PRON
ijpds-3217	91	7	are	be	AUX
ijpds-3217	91	8	suggesting	suggest	VERB
ijpds-3217	91	9	that	that	SCONJ
ijpds-3217	91	10	high	high	ADJ
ijpds-3217	91	11	blood	blood	NOUN
ijpds-3217	91	12	glu	glu	NOUN
ijpds-3217	91	13	levels	level	NOUN
ijpds-3217	91	14	cause	cause	VERB
ijpds-3217	91	15	conformational	conformational	ADJ
ijpds-3217	91	16	changes	change	NOUN
ijpds-3217	91	17	in	in	ADP
ijpds-3217	91	18	the	the	DET
ijpds-3217	91	19	albumin	albumin	ADJ
ijpds-3217	91	20	structure	structure	NOUN
ijpds-3217	91	21	,	,	PUNCT
ijpds-3217	91	22	which	which	PRON
ijpds-3217	91	23	can	can	AUX
ijpds-3217	91	24	decrease	decrease	VERB
ijpds-3217	91	25	the	the	DET
ijpds-3217	91	26	ability	ability	NOUN
ijpds-3217	91	27	to	to	PART
ijpds-3217	91	28	bind	bind	VERB
ijpds-3217	91	29	not	not	PART
ijpds-3217	91	30	only	only	ADV
ijpds-3217	91	31	to	to	ADP
ijpds-3217	91	32	hctz	hctz	NOUN
ijpds-3217	91	33	but	but	CCONJ
ijpds-3217	91	34	also	also	ADV
ijpds-3217	91	35	to	to	ADP
ijpds-3217	91	36	other	other	ADJ
ijpds-3217	91	37	drugs	drug	NOUN
ijpds-3217	91	38	[	[	X
ijpds-3217	91	39	34	34	NUM
ijpds-3217	91	40	]	]	PUNCT
ijpds-3217	91	41	.	.	PUNCT
ijpds-3217	92	1	table	table	NOUN
ijpds-3217	92	2	2	2	NUM
ijpds-3217	92	3	α	α	NOUN
ijpds-3217	92	4	-	-	PUNCT
ijpds-3217	92	5	helix	helix	ADJ
ijpds-3217	92	6	%	%	NOUN
ijpds-3217	92	7	for	for	ADP
ijpds-3217	92	8	hsa	hsa	NOUN
ijpds-3217	92	9	without	without	ADP
ijpds-3217	92	10	and	and	CCONJ
ijpds-3217	92	11	in	in	ADP
ijpds-3217	92	12	the	the	DET
ijpds-3217	92	13	presence	presence	NOUN
ijpds-3217	92	14	of	of	ADP
ijpds-3217	92	15	glucose	glucose	NOUN
ijpds-3217	92	16	in	in	ADP
ijpds-3217	92	17	pbs	pbs	PROPN
ijpds-3217	92	18	solution	solution	NOUN
ijpds-3217	92	19	at	at	ADP
ijpds-3217	92	20	37	37	NUM
ijpds-3217	92	21	ºc	ºc	NOUN
ijpds-3217	92	22	.	.	PUNCT
ijpds-3217	93	1	[	[	X
ijpds-3217	93	2	glucose	glucose	X
ijpds-3217	93	3	]	]	PUNCT
ijpds-3217	93	4	hsa	hsa	NOUN
ijpds-3217	93	5	-	-	PUNCT
ijpds-3217	93	6	glucose	glucose	NOUN
ijpds-3217	93	7	(	(	PUNCT
ijpds-3217	93	8	208	208	NUM
ijpds-3217	93	9	nm	nm	NOUN
ijpds-3217	93	10	)	)	PUNCT
ijpds-3217	93	11	hsa	hsa	PROPN
ijpds-3217	93	12	-	-	PUNCT
ijpds-3217	93	13	glucose	glucose	NOUN
ijpds-3217	93	14	(	(	PUNCT
ijpds-3217	93	15	222	222	NUM
ijpds-3217	93	16	nm	nm	NOUN
ijpds-3217	93	17	)	)	PUNCT
ijpds-3217	93	18	reduction	reduction	NOUN
ijpds-3217	93	19	%	%	NOUN
ijpds-3217	93	20	(	(	PUNCT
ijpds-3217	93	21	208	208	NUM
ijpds-3217	93	22	nm	nm	NOUN
ijpds-3217	93	23	)	)	PUNCT
ijpds-3217	93	24	reduction	reduction	NOUN
ijpds-3217	93	25	%	%	NOUN
ijpds-3217	93	26	(	(	PUNCT
ijpds-3217	93	27	222	222	NUM
ijpds-3217	93	28	nm	nm	NOUN
ijpds-3217	93	29	)	)	PUNCT
ijpds-3217	93	30	0	0	NUM
ijpds-3217	94	1	55.22	55.22	NUM
ijpds-3217	94	2	52.12	52.12	NUM
ijpds-3217	94	3	80	80	NUM
ijpds-3217	94	4	mg	mg	NUM
ijpds-3217	94	5	/	/	SYM
ijpds-3217	94	6	dl	dl	PROPN
ijpds-3217	94	7	52.68	52.68	NUM
ijpds-3217	94	8	50.32	50.32	NUM
ijpds-3217	94	9	4.60	4.60	NUM
ijpds-3217	94	10	3.45	3.45	NUM
ijpds-3217	94	11	320	320	NUM
ijpds-3217	94	12	mg	mg	PROPN
ijpds-3217	94	13	/	/	SYM
ijpds-3217	94	14	dl	dl	PROPN
ijpds-3217	94	15	47.26	47.26	NUM
ijpds-3217	94	16	45.52	45.52	NUM
ijpds-3217	94	17	14.42	14.42	NUM
ijpds-3217	94	18	12.66	12.66	NUM
ijpds-3217	94	19	table	table	NOUN
ijpds-3217	94	20	3	3	NUM
ijpds-3217	94	21	α	α	NOUN
ijpds-3217	94	22	-	-	PUNCT
ijpds-3217	94	23	helix	helix	ADJ
ijpds-3217	94	24	%	%	NOUN
ijpds-3217	94	25	for	for	ADP
ijpds-3217	94	26	hsa	hsa	PROPN
ijpds-3217	94	27	-	-	PUNCT
ijpds-3217	94	28	hctz	hctz	PROPN
ijpds-3217	94	29	in	in	ADP
ijpds-3217	94	30	the	the	DET
ijpds-3217	94	31	presence	presence	NOUN
ijpds-3217	94	32	of	of	ADP
ijpds-3217	94	33	glucose	glucose	NOUN
ijpds-3217	94	34	(	(	PUNCT
ijpds-3217	94	35	80	80	NUM
ijpds-3217	94	36	and	and	CCONJ
ijpds-3217	94	37	320	320	NUM
ijpds-3217	94	38	mg	mg	NUM
ijpds-3217	94	39	/	/	SYM
ijpds-3217	94	40	dl	dl	PROPN
ijpds-3217	94	41	)	)	PUNCT
ijpds-3217	94	42	in	in	ADP
ijpds-3217	94	43	pbs	pbs	PROPN
ijpds-3217	94	44	solution	solution	NOUN
ijpds-3217	94	45	at	at	ADP
ijpds-3217	94	46	37	37	NUM
ijpds-3217	94	47	ºc	ºc	NUM
ijpds-3217	94	48	80	80	NUM
ijpds-3217	94	49	mg	mg	PROPN
ijpds-3217	94	50	/	/	SYM
ijpds-3217	94	51	dl	dl	PROPN
ijpds-3217	94	52	glucose	glucose	NOUN
ijpds-3217	94	53	320	320	NUM
ijpds-3217	94	54	mg	mg	PROPN
ijpds-3217	94	55	/	/	SYM
ijpds-3217	94	56	dl	dl	PROPN
ijpds-3217	94	57	glucose	glucose	NOUN
ijpds-3217	94	58	ratio	ratio	NOUN
ijpds-3217	94	59	hsa	hsa	PROPN
ijpds-3217	94	60	-	-	PUNCT
ijpds-3217	94	61	hctz	hctz	PROPN
ijpds-3217	94	62	208	208	NUM
ijpds-3217	94	63	nm	nm	NUM
ijpds-3217	94	64	222	222	NUM
ijpds-3217	94	65	nm	nm	ADJ
ijpds-3217	94	66	reduction	reduction	NOUN
ijpds-3217	94	67	%	%	NOUN
ijpds-3217	94	68	(	(	PUNCT
ijpds-3217	94	69	222	222	NUM
ijpds-3217	94	70	nm	nm	NOUN
ijpds-3217	94	71	)	)	PUNCT
ijpds-3217	94	72	208	208	NUM
ijpds-3217	94	73	nm	nm	NOUN
ijpds-3217	94	74	(	(	PUNCT
ijpds-3217	94	75	222	222	NUM
ijpds-3217	94	76	nm	nm	NOUN
ijpds-3217	94	77	)	)	PUNCT
ijpds-3217	94	78	reductio	reductio	NOUN
ijpds-3217	94	79	n	n	PRON
ijpds-3217	94	80	%	%	NOUN
ijpds-3217	94	81	(	(	PUNCT
ijpds-3217	94	82	222	222	NUM
ijpds-3217	94	83	nm	nm	NOUN
ijpds-3217	94	84	)	)	PUNCT
ijpds-3217	94	85	1:0	1:0	NOUN
ijpds-3217	95	1	60.5	60.5	NUM
ijpds-3217	95	2	0	0	NUM
ijpds-3217	95	3	58.6	58.6	NUM
ijpds-3217	95	4	9	9	NUM
ijpds-3217	95	5	61.4	61.4	NUM
ijpds-3217	95	6	6	6	NUM
ijpds-3217	95	7	58.9	58.9	NUM
ijpds-3217	95	8	1	1	NUM
ijpds-3217	95	9	1:12	1:12	NUM
ijpds-3217	95	10	58.7	58.7	NUM
ijpds-3217	95	11	3	3	NUM
ijpds-3217	95	12	56.0	56.0	NUM
ijpds-3217	95	13	6	6	NUM
ijpds-3217	95	14	4.48	4.48	NUM
ijpds-3217	95	15	54.0	54.0	NUM
ijpds-3217	95	16	6	6	NUM
ijpds-3217	95	17	51.5	51.5	NUM
ijpds-3217	95	18	2	2	NUM
ijpds-3217	95	19	12.54	12.54	NUM
ijpds-3217	95	20	1:24	1:24	NUM
ijpds-3217	95	21	58.9	58.9	NUM
ijpds-3217	95	22	1	1	NUM
ijpds-3217	95	23	55.6	55.6	NUM
ijpds-3217	95	24	6	6	NUM
ijpds-3217	95	25	5.16	5.16	NUM
ijpds-3217	95	26	51.9	51.9	NUM
ijpds-3217	95	27	0	0	NUM
ijpds-3217	95	28	51.0	51.0	NUM
ijpds-3217	95	29	7	7	NUM
ijpds-3217	95	30	13.30	13.30	NUM
ijpds-3217	95	31	1:48	1:48	NUM
ijpds-3217	95	32	59.4	59.4	NUM
ijpds-3217	95	33	0	0	NUM
ijpds-3217	96	1	54.8	54.8	NUM
ijpds-3217	96	2	8	8	NUM
ijpds-3217	96	3	6.49	6.49	NUM
ijpds-3217	96	4	53.2	53.2	NUM
ijpds-3217	96	5	5	5	NUM
ijpds-3217	96	6	50.7	50.7	NUM
ijpds-3217	96	7	9	9	NUM
ijpds-3217	96	8	13.78	13.78	NUM
ijpds-3217	96	9	the	the	DET
ijpds-3217	96	10	same	same	ADJ
ijpds-3217	96	11	trend	trend	NOUN
ijpds-3217	96	12	was	be	AUX
ijpds-3217	96	13	also	also	ADV
ijpds-3217	96	14	observed	observe	VERB
ijpds-3217	96	15	in	in	ADP
ijpds-3217	96	16	the	the	DET
ijpds-3217	96	17	region	region	NOUN
ijpds-3217	96	18	of	of	ADP
ijpds-3217	96	19	the	the	DET
ijpds-3217	96	20	spectrum	spectrum	NOUN
ijpds-3217	96	21	associated	associate	VERB
ijpds-3217	96	22	with	with	ADP
ijpds-3217	96	23	phe–255	phe–255	PROPN
ijpds-3217	96	24	(	(	PUNCT
ijpds-3217	96	25	at	at	ADP
ijpds-3217	96	26	270	270	NUM
ijpds-3217	96	27	nm	nm	NOUN
ijpds-3217	96	28	)	)	PUNCT
ijpds-3217	96	29	and	and	CCONJ
ijpds-3217	96	30	tyr–275	tyr–275	PROPN
ijpds-3217	96	31	(	(	PUNCT
ijpds-3217	96	32	at	at	ADP
ijpds-3217	96	33	282	282	NUM
ijpds-3217	96	34	nm	nm	NOUN
ijpds-3217	96	35	)	)	PUNCT
ijpds-3217	96	36	residues	residue	NOUN
ijpds-3217	96	37	.	.	PUNCT
ijpds-3217	97	1	the	the	DET
ijpds-3217	97	2	same	same	ADJ
ijpds-3217	97	3	kind	kind	NOUN
ijpds-3217	97	4	of	of	ADP
ijpds-3217	97	5	analysis	analysis	NOUN
ijpds-3217	97	6	was	be	AUX
ijpds-3217	97	7	conducted	conduct	VERB
ijpds-3217	97	8	for	for	ADP
ijpds-3217	97	9	hsahctz	hsahctz	PROPN
ijpds-3217	97	10	in	in	ADP
ijpds-3217	97	11	the	the	DET
ijpds-3217	97	12	solutions	solution	NOUN
ijpds-3217	97	13	containing	contain	VERB
ijpds-3217	97	14	glu	glu	NOUN
ijpds-3217	97	15	80	80	NUM
ijpds-3217	97	16	and	and	CCONJ
ijpds-3217	97	17	320	320	NUM
ijpds-3217	97	18	mg	mg	PROPN
ijpds-3217	97	19	/	/	SYM
ijpds-3217	97	20	dl	dl	PROPN
ijpds-3217	97	21	.	.	PROPN
ijpds-3217	97	22	figures	figure	NOUN
ijpds-3217	97	23	2a	2a	NUM
ijpds-3217	97	24	and	and	CCONJ
ijpds-3217	97	25	2b	2b	NOUN
ijpds-3217	97	26	indicate	indicate	VERB
ijpds-3217	97	27	moderate	moderate	ADJ
ijpds-3217	97	28	and	and	CCONJ
ijpds-3217	97	29	strong	strong	ADJ
ijpds-3217	97	30	perturbations	perturbation	NOUN
ijpds-3217	97	31	in	in	ADP
ijpds-3217	97	32	the	the	DET
ijpds-3217	97	33	secondary	secondary	ADJ
ijpds-3217	97	34	structure	structure	NOUN
ijpds-3217	97	35	of	of	ADP
ijpds-3217	97	36	hsa	hsa	PROPN
ijpds-3217	97	37	for	for	ADP
ijpds-3217	97	38	normoglycemic	normoglycemic	ADJ
ijpds-3217	97	39	and	and	CCONJ
ijpds-3217	97	40	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	97	41	conditions	condition	NOUN
ijpds-3217	97	42	,	,	PUNCT
ijpds-3217	97	43	respectively	respectively	ADV
ijpds-3217	97	44	[	[	X
ijpds-3217	97	45	35	35	NUM
ijpds-3217	97	46	]	]	PUNCT
ijpds-3217	97	47	.	.	PUNCT
ijpds-3217	98	1	the	the	DET
ijpds-3217	98	2	α	α	NOUN
ijpds-3217	98	3	-	-	PUNCT
ijpds-3217	98	4	helix	helix	ADJ
ijpds-3217	98	5	content	content	NOUN
ijpds-3217	98	6	at	at	ADP
ijpds-3217	98	7	222	222	NUM
ijpds-3217	98	8	nm	nm	NOUN
ijpds-3217	98	9	(	(	PUNCT
ijpds-3217	98	10	table	table	NOUN
ijpds-3217	98	11	4	4	NUM
ijpds-3217	98	12	)	)	PUNCT
ijpds-3217	98	13	clearly	clearly	ADV
ijpds-3217	98	14	shows	show	VERB
ijpds-3217	98	15	a	a	DET
ijpds-3217	98	16	higher	high	ADJ
ijpds-3217	98	17	tendency	tendency	NOUN
ijpds-3217	98	18	of	of	ADP
ijpds-3217	98	19	perturbation	perturbation	NOUN
ijpds-3217	98	20	on	on	ADP
ijpds-3217	98	21	the	the	DET
ijpds-3217	98	22	secondary	secondary	ADJ
ijpds-3217	98	23	structure	structure	NOUN
ijpds-3217	98	24	upon	upon	SCONJ
ijpds-3217	98	25	hctz	hctz	PROPN
ijpds-3217	98	26	addition	addition	NOUN
ijpds-3217	98	27	in	in	ADP
ijpds-3217	98	28	the	the	DET
ijpds-3217	98	29	presence	presence	NOUN
ijpds-3217	98	30	than	than	ADP
ijpds-3217	98	31	in	in	ADP
ijpds-3217	98	32	the	the	DET
ijpds-3217	98	33	absence	absence	NOUN
ijpds-3217	98	34	of	of	ADP
ijpds-3217	98	35	glu	glu	NOUN
ijpds-3217	98	36	(	(	PUNCT
ijpds-3217	98	37	for	for	ADP
ijpds-3217	98	38	hsa	hsa	PROPN
ijpds-3217	98	39	:	:	PUNCT
ijpds-3217	98	40	hctz	hctz	PROPN
ijpds-3217	98	41	=	=	PROPN
ijpds-3217	98	42	1:4	1:4	NUM
ijpds-3217	98	43	,	,	PUNCT
ijpds-3217	98	44	maximum	maximum	ADJ
ijpds-3217	98	45	reduction	reduction	NOUN
ijpds-3217	98	46	of	of	ADP
ijpds-3217	98	47	6.49	6.49	NUM
ijpds-3217	98	48	%	%	NOUN
ijpds-3217	98	49	and	and	CCONJ
ijpds-3217	98	50	13.78	13.78	NUM
ijpds-3217	98	51	%	%	NOUN
ijpds-3217	98	52	at	at	ADP
ijpds-3217	98	53	222	222	NUM
ijpds-3217	98	54	nm	nm	NOUN
ijpds-3217	98	55	,	,	PUNCT
ijpds-3217	98	56	in	in	ADP
ijpds-3217	98	57	80	80	NUM
ijpds-3217	98	58	and	and	CCONJ
ijpds-3217	98	59	320	320	NUM
ijpds-3217	98	60	mg	mg	PROPN
ijpds-3217	98	61	/	/	SYM
ijpds-3217	98	62	dl	dl	PROPN
ijpds-3217	98	63	,	,	PUNCT
ijpds-3217	98	64	respectively	respectively	ADV
ijpds-3217	98	65	)	)	PUNCT
ijpds-3217	98	66	.	.	PUNCT
ijpds-3217	99	1	these	these	DET
ijpds-3217	99	2	results	result	NOUN
ijpds-3217	99	3	are	be	AUX
ijpds-3217	99	4	related	relate	VERB
ijpds-3217	99	5	to	to	ADP
ijpds-3217	99	6	spectrofluorimetry	spectrofluorimetry	NOUN
ijpds-3217	99	7	results	result	NOUN
ijpds-3217	99	8	that	that	PRON
ijpds-3217	99	9	suggested	suggest	VERB
ijpds-3217	99	10	a	a	DET
ijpds-3217	99	11	conformational	conformational	ADJ
ijpds-3217	99	12	change	change	NOUN
ijpds-3217	99	13	in	in	ADP
ijpds-3217	99	14	the	the	DET
ijpds-3217	99	15	hsa	hsa	PROPN
ijpds-3217	99	16	structure	structure	NOUN
ijpds-3217	99	17	caused	cause	VERB
ijpds-3217	99	18	by	by	ADP
ijpds-3217	99	19	glu	glu	NOUN
ijpds-3217	99	20	in	in	ADP
ijpds-3217	99	21	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	99	22	concentration	concentration	NOUN
ijpds-3217	99	23	as	as	ADP
ijpds-3217	99	24	responsible	responsible	ADJ
ijpds-3217	99	25	for	for	ADP
ijpds-3217	99	26	the	the	DET
ijpds-3217	99	27	marked	mark	VERB
ijpds-3217	99	28	decrease	decrease	NOUN
ijpds-3217	99	29	in	in	ADP
ijpds-3217	99	30	the	the	DET
ijpds-3217	99	31	binding	bind	VERB
ijpds-3217	99	32	capacity	capacity	NOUN
ijpds-3217	99	33	of	of	ADP
ijpds-3217	99	34	hctz	hctz	PROPN
ijpds-3217	99	35	to	to	PART
ijpds-3217	99	36	has	have	VERB
ijpds-3217	99	37	[	[	X
ijpds-3217	99	38	1	1	NUM
ijpds-3217	99	39	]	]	PUNCT
ijpds-3217	99	40	.	.	PUNCT
ijpds-3217	100	1	table	table	NOUN
ijpds-3217	100	2	4	4	NUM
ijpds-3217	100	3	α	α	NOUN
ijpds-3217	100	4	-	-	PUNCT
ijpds-3217	100	5	helix	helix	ADJ
ijpds-3217	100	6	%	%	NOUN
ijpds-3217	100	7	for	for	ADP
ijpds-3217	100	8	hsa	hsa	PROPN
ijpds-3217	100	9	-	-	PUNCT
ijpds-3217	100	10	hctz	hctz	PROPN
ijpds-3217	100	11	in	in	ADP
ijpds-3217	100	12	the	the	DET
ijpds-3217	100	13	presence	presence	NOUN
ijpds-3217	100	14	of	of	ADP
ijpds-3217	100	15	glucose	glucose	NOUN
ijpds-3217	100	16	(	(	PUNCT
ijpds-3217	100	17	80	80	NUM
ijpds-3217	100	18	and	and	CCONJ
ijpds-3217	100	19	320	320	NUM
ijpds-3217	100	20	mg	mg	NUM
ijpds-3217	100	21	/	/	SYM
ijpds-3217	100	22	dl	dl	PROPN
ijpds-3217	100	23	)	)	PUNCT
ijpds-3217	100	24	in	in	ADP
ijpds-3217	100	25	pbs	pbs	PROPN
ijpds-3217	100	26	solution	solution	NOUN
ijpds-3217	100	27	at	at	ADP
ijpds-3217	100	28	37	37	NUM
ijpds-3217	100	29	ºc	ºc	NOUN
ijpds-3217	100	30	.	.	PROPN
ijpds-3217	100	31	80	80	NUM
ijpds-3217	100	32	mg	mg	PROPN
ijpds-3217	100	33	/	/	SYM
ijpds-3217	100	34	dl	dl	PROPN
ijpds-3217	100	35	glucose	glucose	NOUN
ijpds-3217	100	36	320	320	NUM
ijpds-3217	100	37	mg	mg	PROPN
ijpds-3217	100	38	/	/	SYM
ijpds-3217	100	39	dl	dl	PROPN
ijpds-3217	100	40	glucose	glucose	NOUN
ijpds-3217	100	41	ratio	ratio	NOUN
ijpds-3217	100	42	hsa	hsa	PROPN
ijpds-3217	100	43	-	-	PUNCT
ijpds-3217	100	44	hctz	hctz	PROPN
ijpds-3217	100	45	208	208	NUM
ijpds-3217	100	46	nm	nm	NUM
ijpds-3217	100	47	222	222	NUM
ijpds-3217	100	48	nm	nm	ADJ
ijpds-3217	100	49	reduction	reduction	NOUN
ijpds-3217	100	50	%	%	NOUN
ijpds-3217	100	51	(	(	PUNCT
ijpds-3217	100	52	222	222	NUM
ijpds-3217	100	53	nm	nm	NOUN
ijpds-3217	100	54	)	)	PUNCT
ijpds-3217	100	55	208	208	NUM
ijpds-3217	100	56	nm	nm	NUM
ijpds-3217	100	57	222	222	NUM
ijpds-3217	100	58	nm	nm	ADJ
ijpds-3217	100	59	reduction	reduction	NOUN
ijpds-3217	100	60	%	%	NOUN
ijpds-3217	100	61	(	(	PUNCT
ijpds-3217	100	62	222	222	NUM
ijpds-3217	100	63	nm	nm	NOUN
ijpds-3217	100	64	)	)	PUNCT
ijpds-3217	100	65	1:0	1:0	NOUN
ijpds-3217	101	1	60.5	60.5	NUM
ijpds-3217	101	2	0	0	NUM
ijpds-3217	101	3	58.6	58.6	NUM
ijpds-3217	101	4	9	9	NUM
ijpds-3217	101	5	61.4	61.4	NUM
ijpds-3217	101	6	6	6	NUM
ijpds-3217	101	7	58.9	58.9	NUM
ijpds-3217	101	8	1	1	NUM
ijpds-3217	101	9	1:12	1:12	NUM
ijpds-3217	101	10	58.7	58.7	NUM
ijpds-3217	101	11	3	3	NUM
ijpds-3217	101	12	56.0	56.0	NUM
ijpds-3217	101	13	6	6	NUM
ijpds-3217	101	14	4.48	4.48	NUM
ijpds-3217	101	15	54.0	54.0	NUM
ijpds-3217	101	16	6	6	NUM
ijpds-3217	101	17	51.5	51.5	NUM
ijpds-3217	101	18	2	2	NUM
ijpds-3217	101	19	12.54	12.54	NUM
ijpds-3217	101	20	1:24	1:24	NUM
ijpds-3217	101	21	58.9	58.9	NUM
ijpds-3217	101	22	1	1	NUM
ijpds-3217	101	23	55.6	55.6	NUM
ijpds-3217	101	24	6	6	NUM
ijpds-3217	101	25	5.16	5.16	NUM
ijpds-3217	101	26	51.9	51.9	NUM
ijpds-3217	101	27	0	0	NUM
ijpds-3217	101	28	51.0	51.0	NUM
ijpds-3217	101	29	7	7	NUM
ijpds-3217	101	30	13.30	13.30	NUM
ijpds-3217	101	31	1:48	1:48	NUM
ijpds-3217	101	32	59.4	59.4	NUM
ijpds-3217	101	33	0	0	NUM
ijpds-3217	102	1	54.8	54.8	NUM
ijpds-3217	102	2	8	8	NUM
ijpds-3217	102	3	6.49	6.49	NUM
ijpds-3217	102	4	53.2	53.2	NUM
ijpds-3217	102	5	5	5	NUM
ijpds-3217	102	6	50.7	50.7	NUM
ijpds-3217	102	7	9	9	NUM
ijpds-3217	102	8	13.78	13.78	NUM
ijpds-3217	102	9	for	for	ADP
ijpds-3217	102	10	the	the	DET
ijpds-3217	102	11	near	near	ADJ
ijpds-3217	102	12	-	-	PUNCT
ijpds-3217	102	13	uv	uv	NOUN
ijpds-3217	102	14	cd	cd	NOUN
ijpds-3217	102	15	spectra	spectra	NOUN
ijpds-3217	102	16	of	of	ADP
ijpds-3217	102	17	hsa	hsa	PROPN
ijpds-3217	102	18	-	-	PUNCT
ijpds-3217	102	19	hctz	hctz	PROPN
ijpds-3217	102	20	in	in	ADP
ijpds-3217	102	21	the	the	DET
ijpds-3217	102	22	presence	presence	NOUN
ijpds-3217	102	23	of	of	ADP
ijpds-3217	102	24	glu	glu	NOUN
ijpds-3217	102	25	,	,	PUNCT
ijpds-3217	102	26	unusual	unusual	ADJ
ijpds-3217	102	27	behavior	behavior	NOUN
ijpds-3217	102	28	can	can	AUX
ijpds-3217	102	29	be	be	AUX
ijpds-3217	102	30	seen	see	VERB
ijpds-3217	102	31	(	(	PUNCT
ijpds-3217	102	32	figures	figure	NOUN
ijpds-3217	102	33	2c	2c	NOUN
ijpds-3217	102	34	and	and	CCONJ
ijpds-3217	102	35	2d	2d	NUM
ijpds-3217	102	36	)	)	PUNCT
ijpds-3217	102	37	.	.	PUNCT
ijpds-3217	103	1	in	in	ADP
ijpds-3217	103	2	the	the	DET
ijpds-3217	103	3	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	103	4	condition	condition	NOUN
ijpds-3217	103	5	,	,	PUNCT
ijpds-3217	103	6	the	the	DET
ijpds-3217	103	7	tertiary	tertiary	ADJ
ijpds-3217	103	8	contacts	contact	NOUN
ijpds-3217	103	9	decreased	decrease	VERB
ijpds-3217	103	10	in	in	ADP
ijpds-3217	103	11	phe	phe	PROPN
ijpds-3217	103	12	and	and	CCONJ
ijpds-3217	103	13	tyr	tyr	PROPN
ijpds-3217	103	14	regions	region	NOUN
ijpds-3217	103	15	,	,	PUNCT
ijpds-3217	103	16	due	due	ADP
ijpds-3217	103	17	to	to	ADP
ijpds-3217	103	18	the	the	DET
ijpds-3217	103	19	decreased	decrease	VERB
ijpds-3217	103	20	αhelical	αhelical	ADJ
ijpds-3217	103	21	content	content	NOUN
ijpds-3217	103	22	in	in	ADP
ijpds-3217	103	23	the	the	DET
ijpds-3217	103	24	glu	glu	NOUN
ijpds-3217	103	25	concentration	concentration	NOUN
ijpds-3217	103	26	range	range	NOUN
ijpds-3217	103	27	under	under	ADP
ijpds-3217	103	28	study	study	NOUN
ijpds-3217	103	29	,	,	PUNCT
ijpds-3217	103	30	which	which	PRON
ijpds-3217	103	31	may	may	AUX
ijpds-3217	103	32	be	be	AUX
ijpds-3217	103	33	responsible	responsible	ADJ
ijpds-3217	103	34	for	for	ADP
ijpds-3217	103	35	the	the	DET
ijpds-3217	103	36	structure	structure	NOUN
ijpds-3217	103	37	loss	loss	NOUN
ijpds-3217	103	38	[	[	X
ijpds-3217	103	39	32	32	NUM
ijpds-3217	103	40	]	]	PUNCT
ijpds-3217	103	41	.	.	PUNCT
ijpds-3217	104	1	but	but	CCONJ
ijpds-3217	104	2	an	an	DET
ijpds-3217	104	3	opposite	opposite	ADJ
ijpds-3217	104	4	effect	effect	NOUN
ijpds-3217	104	5	is	be	AUX
ijpds-3217	104	6	found	find	VERB
ijpds-3217	104	7	in	in	ADP
ijpds-3217	104	8	the	the	DET
ijpds-3217	104	9	trp-214	trp-214	ADJ
ijpds-3217	104	10	region	region	NOUN
ijpds-3217	104	11	(	(	PUNCT
ijpds-3217	104	12	290	290	NUM
ijpds-3217	104	13	-	-	SYM
ijpds-3217	104	14	305	305	NUM
ijpds-3217	104	15	nm	nm	NOUN
ijpds-3217	104	16	)	)	PUNCT
ijpds-3217	104	17	.	.	PUNCT
ijpds-3217	105	1	overall	overall	ADV
ijpds-3217	105	2	,	,	PUNCT
ijpds-3217	105	3	the	the	DET
ijpds-3217	105	4	presence	presence	NOUN
ijpds-3217	105	5	of	of	ADP
ijpds-3217	105	6	glu	glu	NOUN
ijpds-3217	105	7	destabilized	destabilize	VERB
ijpds-3217	105	8	the	the	DET
ijpds-3217	105	9	protein	protein	NOUN
ijpds-3217	105	10	structure	structure	NOUN
ijpds-3217	105	11	,	,	PUNCT
ijpds-3217	105	12	and	and	CCONJ
ijpds-3217	105	13	this	this	DET
ijpds-3217	105	14	destabilizing	destabilizing	ADJ
ijpds-3217	105	15	effect	effect	NOUN
ijpds-3217	105	16	of	of	ADP
ijpds-3217	105	17	glu	glu	NOUN
ijpds-3217	105	18	becomes	become	VERB
ijpds-3217	105	19	more	more	ADV
ijpds-3217	105	20	evident	evident	ADJ
ijpds-3217	105	21	with	with	ADP
ijpds-3217	105	22	the	the	DET
ijpds-3217	105	23	increase	increase	NOUN
ijpds-3217	105	24	in	in	ADP
ijpds-3217	105	25	the	the	DET
ijpds-3217	105	26	drug	drug	NOUN
ijpds-3217	105	27	concentration	concentration	NOUN
ijpds-3217	105	28	.	.	PUNCT
ijpds-3217	106	1	theoretical	theoretical	ADJ
ijpds-3217	106	2	evaluation	evaluation	NOUN
ijpds-3217	106	3	of	of	ADP
ijpds-3217	106	4	the	the	DET
ijpds-3217	106	5	binding	bind	VERB
ijpds-3217	106	6	ability	ability	NOUN
ijpds-3217	106	7	to	to	PART
ijpds-3217	106	8	identify	identify	VERB
ijpds-3217	106	9	the	the	DET
ijpds-3217	106	10	possible	possible	ADJ
ijpds-3217	106	11	main	main	ADJ
ijpds-3217	106	12	binding	bind	VERB
ijpds-3217	106	13	sites	site	NOUN
ijpds-3217	106	14	(	(	PUNCT
ijpds-3217	106	15	sites	site	NOUN
ijpds-3217	106	16	i	i	PRON
ijpds-3217	106	17	,	,	PUNCT
ijpds-3217	106	18	ii	ii	PROPN
ijpds-3217	106	19	,	,	PUNCT
ijpds-3217	106	20	or	or	CCONJ
ijpds-3217	106	21	iii	iii	NOUN
ijpds-3217	106	22	,	,	PUNCT
ijpds-3217	106	23	located	locate	VERB
ijpds-3217	106	24	in	in	ADP
ijpds-3217	106	25	subdomain	subdomain	NOUN
ijpds-3217	106	26	iia	iia	NOUN
ijpds-3217	106	27	,	,	PUNCT
ijpds-3217	106	28	iiia	iiia	VERB
ijpds-3217	106	29	,	,	PUNCT
ijpds-3217	106	30	and	and	CCONJ
ijpds-3217	106	31	ib	ib	INTJ
ijpds-3217	106	32	,	,	PUNCT
ijpds-3217	106	33	respectively	respectively	ADV
ijpds-3217	106	34	)	)	PUNCT
ijpds-3217	107	1	[	[	X
ijpds-3217	107	2	36	36	NUM
ijpds-3217	107	3	]	]	X
ijpds-3217	107	4	,	,	PUNCT
ijpds-3217	107	5	as	as	ADV
ijpds-3217	107	6	well	well	ADV
ijpds-3217	107	7	as	as	ADP
ijpds-3217	107	8	the	the	DET
ijpds-3217	107	9	amino	amino	NOUN
ijpds-3217	107	10	acid	acid	NOUN
ijpds-3217	107	11	residues	residue	NOUN
ijpds-3217	107	12	involved	involve	VERB
ijpds-3217	107	13	in	in	ADP
ijpds-3217	107	14	the	the	DET
ijpds-3217	107	15	hsahctz	hsahctz	PROPN
ijpds-3217	107	16	interaction	interaction	NOUN
ijpds-3217	107	17	,	,	PUNCT
ijpds-3217	107	18	and	and	CCONJ
ijpds-3217	107	19	the	the	DET
ijpds-3217	107	20	impact	impact	NOUN
ijpds-3217	107	21	of	of	ADP
ijpds-3217	107	22	glu	glu	NOUN
ijpds-3217	107	23	addition	addition	NOUN
ijpds-3217	107	24	(	(	PUNCT
ijpds-3217	107	25	in	in	ADP
ijpds-3217	107	26	open	open	ADJ
ijpds-3217	107	27	and	and	CCONJ
ijpds-3217	107	28	cyclic	cyclic	ADJ
ijpds-3217	107	29	forms	form	NOUN
ijpds-3217	107	30	)	)	PUNCT
ijpds-3217	107	31	in	in	ADP
ijpds-3217	107	32	the	the	DET
ijpds-3217	107	33	binding	bind	VERB
ijpds-3217	107	34	ability	ability	NOUN
ijpds-3217	107	35	,	,	PUNCT
ijpds-3217	107	36	molecular	molecular	ADJ
ijpds-3217	107	37	docking	docking	NOUN
ijpds-3217	107	38	calculations	calculation	NOUN
ijpds-3217	107	39	were	be	AUX
ijpds-3217	107	40	performed	perform	VERB
ijpds-3217	107	41	with	with	ADP
ijpds-3217	107	42	gold	gold	NOUN
ijpds-3217	107	43	5.7	5.7	NUM
ijpds-3217	107	44	software	software	NOUN
ijpds-3217	107	45	.	.	PUNCT
ijpds-3217	108	1	soares	soar	VERB
ijpds-3217	108	2	et	et	PROPN
ijpds-3217	108	3	al	al	PROPN
ijpds-3217	108	4	hsa	hsa	PROPN
ijpds-3217	108	5	-	-	PUNCT
ijpds-3217	108	6	hctz	hctz	ADJ
ijpds-3217	108	7	interactions	interaction	NOUN
ijpds-3217	108	8	based	base	VERB
ijpds-3217	108	9	on	on	ADP
ijpds-3217	108	10	glucose	glucose	NOUN
ijpds-3217	108	11	concentrations	concentration	NOUN
ijpds-3217	108	12	vol	vol	NOUN
ijpds-3217	108	13	1	1	NUM
ijpds-3217	108	14	|	|	NOUN
ijpds-3217	108	15	issue	issue	NOUN
ijpds-3217	108	16	2	2	NUM
ijpds-3217	109	1	|	|	ADV
ijpds-3217	109	2	jul	jul	PROPN
ijpds-3217	109	3	sep	sep	PROPN
ijpds-3217	109	4	2022	2022	NUM
ijpds-3217	109	5	indian	indian	PROPN
ijpds-3217	109	6	j	j	PROPN
ijpds-3217	109	7	pharm	pharm	PROPN
ijpds-3217	109	8	drug	drug	PROPN
ijpds-3217	109	9	studies	study	NOUN
ijpds-3217	109	10	|	|	ADV
ijpds-3217	109	11	60	60	NUM
ijpds-3217	109	12	from	from	ADP
ijpds-3217	109	13	literature	literature	NOUN
ijpds-3217	109	14	,	,	PUNCT
ijpds-3217	109	15	it	it	PRON
ijpds-3217	109	16	is	be	AUX
ijpds-3217	109	17	known	know	VERB
ijpds-3217	109	18	that	that	SCONJ
ijpds-3217	109	19	in	in	ADP
ijpds-3217	109	20	a	a	DET
ijpds-3217	109	21	plasma	plasma	NOUN
ijpds-3217	109	22	medium	medium	NOUN
ijpds-3217	109	23	,	,	PUNCT
ijpds-3217	109	24	dglucose	dglucose	NOUN
ijpds-3217	109	25	is	be	AUX
ijpds-3217	109	26	found	find	VERB
ijpds-3217	109	27	essentially	essentially	ADV
ijpds-3217	109	28	as	as	ADP
ijpds-3217	109	29	a	a	DET
ijpds-3217	109	30	mixture	mixture	NOUN
ijpds-3217	109	31	of	of	ADP
ijpds-3217	109	32	two	two	NUM
ijpds-3217	109	33	anomers	anomer	NOUN
ijpds-3217	109	34	(	(	PUNCT
ijpds-3217	109	35	roughly	roughly	ADV
ijpds-3217	109	36	one	one	NUM
ijpds-3217	109	37	-	-	PUNCT
ijpds-3217	109	38	third	third	NOUN
ijpds-3217	109	39	of	of	ADP
ijpds-3217	109	40	α	α	NOUN
ijpds-3217	109	41	-	-	PUNCT
ijpds-3217	109	42	d	d	NOUN
ijpds-3217	109	43	-	-	NOUN
ijpds-3217	109	44	glucopyranose	glucopyranose	NOUN
ijpds-3217	109	45	and	and	CCONJ
ijpds-3217	109	46	about	about	ADP
ijpds-3217	109	47	twothirds	twothird	NOUN
ijpds-3217	109	48	as	as	ADP
ijpds-3217	109	49	β	β	NOUN
ijpds-3217	109	50	-	-	ADJ
ijpds-3217	109	51	d	d	ADJ
ijpds-3217	109	52	glucopyranose	glucopyranose	NOUN
ijpds-3217	109	53	)	)	PUNCT
ijpds-3217	109	54	,	,	PUNCT
ijpds-3217	109	55	with	with	ADP
ijpds-3217	109	56	practically	practically	ADV
ijpds-3217	109	57	no	no	PRON
ijpds-3217	109	58	furanose	furanose	NOUN
ijpds-3217	109	59	forms	form	NOUN
ijpds-3217	109	60	[	[	X
ijpds-3217	109	61	37	37	NUM
ijpds-3217	109	62	]	]	PUNCT
ijpds-3217	109	63	and	and	CCONJ
ijpds-3217	109	64	the	the	DET
ijpds-3217	109	65	interconversion	interconversion	NOUN
ijpds-3217	109	66	between	between	ADP
ijpds-3217	109	67	open	open	ADJ
ijpds-3217	109	68	-	-	PUNCT
ijpds-3217	109	69	chain	chain	NOUN
ijpds-3217	109	70	aldehyde	aldehyde	NOUN
ijpds-3217	109	71	and	and	CCONJ
ijpds-3217	109	72	ring	ring	NOUN
ijpds-3217	109	73	forms	form	NOUN
ijpds-3217	109	74	is	be	AUX
ijpds-3217	109	75	fast	fast	ADJ
ijpds-3217	109	76	and	and	CCONJ
ijpds-3217	109	77	affected	affect	VERB
ijpds-3217	109	78	by	by	ADP
ijpds-3217	109	79	the	the	DET
ijpds-3217	109	80	medium	medium	ADJ
ijpds-3217	109	81	conditions	condition	NOUN
ijpds-3217	109	82	,	,	PUNCT
ijpds-3217	109	83	being	be	AUX
ijpds-3217	109	84	energetically	energetically	ADV
ijpds-3217	109	85	favorable	favorable	ADJ
ijpds-3217	109	86	in	in	ADP
ijpds-3217	109	87	the	the	DET
ijpds-3217	109	88	cyclic	cyclic	NOUN
ijpds-3217	109	89	than	than	ADP
ijpds-3217	109	90	the	the	DET
ijpds-3217	109	91	open	open	ADJ
ijpds-3217	109	92	form	form	NOUN
ijpds-3217	109	93	(	(	PUNCT
ijpds-3217	109	94	e.g.	e.g.	ADV
ijpds-3217	109	95	for	for	ADP
ijpds-3217	109	96	glu	glu	NOUN
ijpds-3217	109	97	,	,	PUNCT
ijpds-3217	109	98	about	about	ADV
ijpds-3217	109	99	99.98	99.98	NUM
ijpds-3217	109	100	%	%	NOUN
ijpds-3217	109	101	is	be	AUX
ijpds-3217	109	102	cyclic	cyclic	ADJ
ijpds-3217	109	103	in	in	ADP
ijpds-3217	109	104	water	water	NOUN
ijpds-3217	109	105	)	)	PUNCT
ijpds-3217	110	1	[	[	X
ijpds-3217	110	2	38	38	NUM
ijpds-3217	110	3	]	]	PUNCT
ijpds-3217	110	4	.	.	PUNCT
ijpds-3217	111	1	thus	thus	ADV
ijpds-3217	111	2	,	,	PUNCT
ijpds-3217	111	3	all	all	DET
ijpds-3217	111	4	molecular	molecular	ADJ
ijpds-3217	111	5	docking	docking	NOUN
ijpds-3217	111	6	calculations	calculation	NOUN
ijpds-3217	111	7	for	for	ADP
ijpds-3217	111	8	glu	glu	NOUN
ijpds-3217	111	9	were	be	AUX
ijpds-3217	111	10	carried	carry	VERB
ijpds-3217	111	11	out	out	ADP
ijpds-3217	111	12	only	only	ADV
ijpds-3217	111	13	assuming	assume	VERB
ijpds-3217	111	14	β	β	X
ijpds-3217	111	15	-	-	ADJ
ijpds-3217	111	16	d	d	NOUN
ijpds-3217	111	17	-	-	NOUN
ijpds-3217	111	18	glucose	glucose	NOUN
ijpds-3217	111	19	in	in	ADP
ijpds-3217	111	20	both	both	CCONJ
ijpds-3217	111	21	cyclic	cyclic	ADJ
ijpds-3217	111	22	and	and	CCONJ
ijpds-3217	111	23	open	open	ADJ
ijpds-3217	111	24	forms	form	NOUN
ijpds-3217	111	25	.	.	PUNCT
ijpds-3217	112	1	table	table	NOUN
ijpds-3217	112	2	5	5	NUM
ijpds-3217	112	3	shows	show	VERB
ijpds-3217	112	4	the	the	DET
ijpds-3217	112	5	docking	docking	NOUN
ijpds-3217	112	6	score	score	NOUN
ijpds-3217	112	7	values	value	NOUN
ijpds-3217	112	8	(	(	PUNCT
ijpds-3217	112	9	dimensionless	dimensionless	NOUN
ijpds-3217	112	10	)	)	PUNCT
ijpds-3217	112	11	for	for	SCONJ
ijpds-3217	112	12	the	the	DET
ijpds-3217	112	13	best	good	ADJ
ijpds-3217	112	14	docking	docking	NOUN
ijpds-3217	112	15	pose	pose	VERB
ijpds-3217	112	16	at	at	ADP
ijpds-3217	112	17	the	the	DET
ijpds-3217	112	18	three	three	NUM
ijpds-3217	112	19	main	main	ADJ
ijpds-3217	112	20	binding	bind	VERB
ijpds-3217	112	21	sites	site	NOUN
ijpds-3217	112	22	of	of	ADP
ijpds-3217	112	23	the	the	DET
ijpds-3217	112	24	hsa	hsa	PROPN
ijpds-3217	112	25	structure	structure	NOUN
ijpds-3217	112	26	available	available	ADJ
ijpds-3217	112	27	for	for	ADP
ijpds-3217	112	28	interaction	interaction	NOUN
ijpds-3217	112	29	hsa	hsa	PROPN
ijpds-3217	112	30	-	-	PUNCT
ijpds-3217	112	31	hctz	hctz	NOUN
ijpds-3217	112	32	,	,	PUNCT
ijpds-3217	112	33	hsa	hsa	PROPN
ijpds-3217	112	34	-	-	PUNCT
ijpds-3217	112	35	glu	glu	NOUN
ijpds-3217	112	36	,	,	PUNCT
ijpds-3217	112	37	and	and	CCONJ
ijpds-3217	112	38	hsa-glu.hctz	hsa-glu.hctz	NOUN
ijpds-3217	112	39	.	.	PUNCT
ijpds-3217	113	1	table	table	NOUN
ijpds-3217	113	2	5	5	NUM
ijpds-3217	113	3	docking	docking	NOUN
ijpds-3217	113	4	score	score	NOUN
ijpds-3217	113	5	values	value	NOUN
ijpds-3217	113	6	(	(	PUNCT
ijpds-3217	113	7	dimensionless	dimensionless	NOUN
ijpds-3217	113	8	)	)	PUNCT
ijpds-3217	113	9	for	for	ADP
ijpds-3217	113	10	the	the	DET
ijpds-3217	113	11	interaction	interaction	NOUN
ijpds-3217	113	12	of	of	ADP
ijpds-3217	113	13	hsa	hsa	PROPN
ijpds-3217	113	14	with	with	ADP
ijpds-3217	113	15	hctz	hctz	NOUN
ijpds-3217	113	16	and	and	CCONJ
ijpds-3217	113	17	glucose	glucose	NOUN
ijpds-3217	113	18	at	at	ADP
ijpds-3217	113	19	sites	site	NOUN
ijpds-3217	113	20	i	i	PROPN
ijpds-3217	113	21	-	-	PUNCT
ijpds-3217	113	22	iii	iii	PROPN
ijpds-3217	113	23	.	.	PUNCT
ijpds-3217	113	24	sample	sample	NOUN
ijpds-3217	113	25	site	site	NOUN
ijpds-3217	114	1	i	i	PRON
ijpds-3217	114	2	site	site	PROPN
ijpds-3217	114	3	ii	ii	PROPN
ijpds-3217	114	4	site	site	PROPN
ijpds-3217	114	5	iii	iii	NUM
ijpds-3217	114	6	hsa	hsa	PROPN
ijpds-3217	114	7	-	-	PUNCT
ijpds-3217	114	8	hctz	hctz	NOUN
ijpds-3217	114	9	58.3	58.3	NUM
ijpds-3217	114	10	51.1	51.1	NUM
ijpds-3217	114	11	40.8	40.8	NUM
ijpds-3217	114	12	hsa	hsa	NOUN
ijpds-3217	114	13	-	-	ADJ
ijpds-3217	114	14	open	open	ADJ
ijpds-3217	114	15	-	-	PUNCT
ijpds-3217	114	16	glu	glu	NOUN
ijpds-3217	114	17	56.6	56.6	NUM
ijpds-3217	114	18	43.5	43.5	NUM
ijpds-3217	114	19	43.6	43.6	NUM
ijpds-3217	114	20	hsa	hsa	PROPN
ijpds-3217	114	21	-	-	PUNCT
ijpds-3217	114	22	cyclic	cyclic	ADJ
ijpds-3217	114	23	-	-	PUNCT
ijpds-3217	114	24	glu	glu	NOUN
ijpds-3217	114	25	47.6	47.6	NUM
ijpds-3217	114	26	41.8	41.8	NUM
ijpds-3217	114	27	39.6	39.6	NUM
ijpds-3217	114	28	hsa-open-glu.hctz	hsa-open-glu.hctz	PROPN
ijpds-3217	114	29	64.6	64.6	NUM
ijpds-3217	114	30	41.2	41.2	NUM
ijpds-3217	114	31	50.4	50.4	NUM
ijpds-3217	114	32	hsa-cyclic-glu.hctz	hsa-cyclic-glu.hctz	PROPN
ijpds-3217	114	33	49.9	49.9	NUM
ijpds-3217	114	34	39.0	39.0	NUM
ijpds-3217	114	35	41.8	41.8	NUM
ijpds-3217	114	36	the	the	DET
ijpds-3217	114	37	site	site	NOUN
ijpds-3217	114	38	i	i	PRON
ijpds-3217	114	39	had	have	VERB
ijpds-3217	114	40	the	the	DET
ijpds-3217	114	41	highest	high	ADJ
ijpds-3217	114	42	docking	docking	NOUN
ijpds-3217	114	43	score	score	NOUN
ijpds-3217	114	44	value	value	NOUN
ijpds-3217	114	45	,	,	PUNCT
ijpds-3217	114	46	the	the	DET
ijpds-3217	114	47	results	result	NOUN
ijpds-3217	114	48	of	of	ADP
ijpds-3217	114	49	molecular	molecular	ADJ
ijpds-3217	114	50	docking	docking	NOUN
ijpds-3217	114	51	suggested	suggest	VERB
ijpds-3217	114	52	the	the	DET
ijpds-3217	114	53	subdomain	subdomain	NOUN
ijpds-3217	114	54	iia	iia	NOUN
ijpds-3217	114	55	as	as	ADP
ijpds-3217	114	56	the	the	DET
ijpds-3217	114	57	main	main	ADJ
ijpds-3217	114	58	binding	bind	VERB
ijpds-3217	114	59	site	site	NOUN
ijpds-3217	114	60	for	for	ADP
ijpds-3217	114	61	hsa	hsa	PROPN
ijpds-3217	114	62	-	-	PUNCT
ijpds-3217	114	63	hctz	hctz	NOUN
ijpds-3217	114	64	,	,	PUNCT
ijpds-3217	114	65	hsa	hsa	PROPN
ijpds-3217	114	66	-	-	ADJ
ijpds-3217	114	67	open	open	ADJ
ijpds-3217	114	68	-	-	PUNCT
ijpds-3217	114	69	glu	glu	NOUN
ijpds-3217	114	70	,	,	PUNCT
ijpds-3217	114	71	and	and	CCONJ
ijpds-3217	114	72	hsacyclic	hsacyclic	ADJ
ijpds-3217	114	73	-	-	PUNCT
ijpds-3217	114	74	glu	glu	NOUN
ijpds-3217	114	75	,	,	PUNCT
ijpds-3217	114	76	confirming	confirm	VERB
ijpds-3217	114	77	results	result	NOUN
ijpds-3217	114	78	from	from	ADP
ijpds-3217	114	79	spectrofluorimetric	spectrofluorimetric	ADJ
ijpds-3217	114	80	[	[	X
ijpds-3217	114	81	1	1	NUM
ijpds-3217	114	82	]	]	PUNCT
ijpds-3217	114	83	.	.	PUNCT
ijpds-3217	115	1	although	although	SCONJ
ijpds-3217	115	2	glu	glu	NOUN
ijpds-3217	115	3	in	in	ADP
ijpds-3217	115	4	its	its	PRON
ijpds-3217	115	5	open	open	ADJ
ijpds-3217	115	6	form	form	NOUN
ijpds-3217	115	7	is	be	AUX
ijpds-3217	115	8	in	in	ADP
ijpds-3217	115	9	a	a	DET
ijpds-3217	115	10	smaller	small	ADJ
ijpds-3217	115	11	proportion	proportion	NOUN
ijpds-3217	115	12	than	than	ADP
ijpds-3217	115	13	its	its	PRON
ijpds-3217	115	14	cyclic	cyclic	ADJ
ijpds-3217	115	15	form	form	NOUN
ijpds-3217	115	16	,	,	PUNCT
ijpds-3217	115	17	the	the	DET
ijpds-3217	115	18	results	result	NOUN
ijpds-3217	115	19	of	of	ADP
ijpds-3217	115	20	molecular	molecular	ADJ
ijpds-3217	115	21	docking	docking	NOUN
ijpds-3217	115	22	suggested	suggest	VERB
ijpds-3217	115	23	a	a	DET
ijpds-3217	115	24	higher	high	ADJ
ijpds-3217	115	25	docking	docking	NOUN
ijpds-3217	115	26	score	score	NOUN
ijpds-3217	115	27	for	for	ADP
ijpds-3217	115	28	the	the	DET
ijpds-3217	115	29	open	open	NOUN
ijpds-3217	115	30	than	than	ADP
ijpds-3217	115	31	for	for	ADP
ijpds-3217	115	32	the	the	DET
ijpds-3217	115	33	cyclic	cyclic	ADJ
ijpds-3217	115	34	form	form	NOUN
ijpds-3217	115	35	(	(	PUNCT
ijpds-3217	115	36	56.6	56.6	NUM
ijpds-3217	115	37	and	and	CCONJ
ijpds-3217	115	38	47.6	47.6	NUM
ijpds-3217	115	39	,	,	PUNCT
ijpds-3217	115	40	respectively	respectively	ADV
ijpds-3217	115	41	)	)	PUNCT
ijpds-3217	115	42	,	,	PUNCT
ijpds-3217	115	43	probably	probably	ADV
ijpds-3217	115	44	due	due	ADP
ijpds-3217	115	45	to	to	ADP
ijpds-3217	115	46	the	the	DET
ijpds-3217	115	47	greater	great	ADJ
ijpds-3217	115	48	flexibility	flexibility	NOUN
ijpds-3217	115	49	of	of	ADP
ijpds-3217	115	50	the	the	DET
ijpds-3217	115	51	open	open	ADJ
ijpds-3217	115	52	-	-	PUNCT
ijpds-3217	115	53	glu	glu	NOUN
ijpds-3217	115	54	to	to	PART
ijpds-3217	115	55	adapt	adapt	VERB
ijpds-3217	115	56	to	to	ADP
ijpds-3217	115	57	the	the	DET
ijpds-3217	115	58	protein	protein	NOUN
ijpds-3217	115	59	-	-	PUNCT
ijpds-3217	115	60	binding	bind	VERB
ijpds-3217	115	61	pocket	pocket	NOUN
ijpds-3217	115	62	.	.	PUNCT
ijpds-3217	116	1	in	in	ADP
ijpds-3217	116	2	addition	addition	NOUN
ijpds-3217	116	3	,	,	PUNCT
ijpds-3217	116	4	if	if	SCONJ
ijpds-3217	116	5	hctz	hctz	PROPN
ijpds-3217	116	6	and	and	CCONJ
ijpds-3217	116	7	glu	glu	NOUN
ijpds-3217	116	8	simultaneously	simultaneously	ADV
ijpds-3217	116	9	bind	bind	VERB
ijpds-3217	116	10	to	to	ADP
ijpds-3217	116	11	the	the	DET
ijpds-3217	116	12	same	same	ADJ
ijpds-3217	116	13	protein	protein	NOUN
ijpds-3217	116	14	pocket	pocket	NOUN
ijpds-3217	116	15	,	,	PUNCT
ijpds-3217	116	16	the	the	DET
ijpds-3217	116	17	results	result	NOUN
ijpds-3217	116	18	of	of	ADP
ijpds-3217	116	19	molecular	molecular	ADJ
ijpds-3217	116	20	docking	docking	NOUN
ijpds-3217	116	21	also	also	ADV
ijpds-3217	116	22	suggested	suggest	VERB
ijpds-3217	116	23	site	site	NOUN
ijpds-3217	116	24	i	i	PRON
ijpds-3217	116	25	as	as	ADP
ijpds-3217	116	26	the	the	DET
ijpds-3217	116	27	main	main	ADJ
ijpds-3217	116	28	region	region	NOUN
ijpds-3217	116	29	for	for	ADP
ijpds-3217	116	30	this	this	DET
ijpds-3217	116	31	interaction	interaction	NOUN
ijpds-3217	116	32	.	.	PUNCT
ijpds-3217	117	1	furthermore	furthermore	ADV
ijpds-3217	117	2	,	,	PUNCT
ijpds-3217	117	3	according	accord	VERB
ijpds-3217	117	4	to	to	ADP
ijpds-3217	117	5	the	the	DET
ijpds-3217	117	6	theoretical	theoretical	ADJ
ijpds-3217	117	7	analysis	analysis	NOUN
ijpds-3217	117	8	,	,	PUNCT
ijpds-3217	117	9	the	the	DET
ijpds-3217	117	10	interaction	interaction	NOUN
ijpds-3217	117	11	hsaopenglu.hctz	hsaopenglu.hctz	PROPN
ijpds-3217	117	12	is	be	AUX
ijpds-3217	117	13	more	more	ADV
ijpds-3217	117	14	favorable	favorable	ADJ
ijpds-3217	117	15	than	than	ADP
ijpds-3217	117	16	hsa	hsa	NOUN
ijpds-3217	117	17	-	-	ADJ
ijpds-3217	117	18	open	open	ADJ
ijpds-3217	117	19	-	-	PUNCT
ijpds-3217	117	20	glu	glu	NOUN
ijpds-3217	117	21	and	and	CCONJ
ijpds-3217	117	22	hsa	hsa	PROPN
ijpds-3217	117	23	-	-	PUNCT
ijpds-3217	117	24	hctz	hctz	PROPN
ijpds-3217	117	25	(	(	PUNCT
ijpds-3217	117	26	docking	dock	VERB
ijpds-3217	117	27	score	score	NOUN
ijpds-3217	117	28	values	value	NOUN
ijpds-3217	117	29	:	:	PUNCT
ijpds-3217	117	30	64.6	64.6	NUM
ijpds-3217	117	31	,	,	PUNCT
ijpds-3217	117	32	56.6	56.6	NUM
ijpds-3217	117	33	,	,	PUNCT
ijpds-3217	117	34	and	and	CCONJ
ijpds-3217	117	35	58.3	58.3	NUM
ijpds-3217	117	36	,	,	PUNCT
ijpds-3217	117	37	respectively	respectively	ADV
ijpds-3217	117	38	)	)	PUNCT
ijpds-3217	117	39	.	.	PUNCT
ijpds-3217	118	1	on	on	ADP
ijpds-3217	118	2	the	the	DET
ijpds-3217	118	3	other	other	ADJ
ijpds-3217	118	4	hand	hand	NOUN
ijpds-3217	118	5	,	,	PUNCT
ijpds-3217	118	6	cyclic	cyclic	ADJ
ijpds-3217	118	7	-	-	PUNCT
ijpds-3217	118	8	glu	glu	NOUN
ijpds-3217	118	9	showed	show	VERB
ijpds-3217	118	10	the	the	DET
ijpds-3217	118	11	opposite	opposite	ADJ
ijpds-3217	118	12	trend	trend	NOUN
ijpds-3217	118	13	,	,	PUNCT
ijpds-3217	118	14	decreasing	decrease	VERB
ijpds-3217	118	15	the	the	DET
ijpds-3217	118	16	binding	bind	VERB
ijpds-3217	118	17	capacity	capacity	NOUN
ijpds-3217	118	18	of	of	ADP
ijpds-3217	118	19	hctz	hctz	NOUN
ijpds-3217	118	20	to	to	ADP
ijpds-3217	118	21	the	the	DET
ijpds-3217	118	22	same	same	ADJ
ijpds-3217	118	23	binding	bind	VERB
ijpds-3217	118	24	pocket	pocket	NOUN
ijpds-3217	118	25	.	.	PUNCT
ijpds-3217	119	1	experimental	experimental	ADJ
ijpds-3217	119	2	data	datum	NOUN
ijpds-3217	119	3	also	also	ADV
ijpds-3217	119	4	indicated	indicate	VERB
ijpds-3217	119	5	a	a	DET
ijpds-3217	119	6	negative	negative	ADJ
ijpds-3217	119	7	effect	effect	NOUN
ijpds-3217	119	8	of	of	ADP
ijpds-3217	119	9	glu	glu	NOUN
ijpds-3217	119	10	on	on	ADP
ijpds-3217	119	11	the	the	DET
ijpds-3217	119	12	hsa	hsa	PROPN
ijpds-3217	119	13	-	-	PUNCT
ijpds-3217	119	14	hctz	hctz	ADJ
ijpds-3217	119	15	interaction	interaction	NOUN
ijpds-3217	119	16	[	[	X
ijpds-3217	119	17	1	1	NUM
ijpds-3217	119	18	]	]	PUNCT
ijpds-3217	119	19	,	,	PUNCT
ijpds-3217	119	20	which	which	PRON
ijpds-3217	119	21	may	may	AUX
ijpds-3217	119	22	probably	probably	ADV
ijpds-3217	119	23	be	be	AUX
ijpds-3217	119	24	associated	associate	VERB
ijpds-3217	119	25	with	with	ADP
ijpds-3217	119	26	the	the	DET
ijpds-3217	119	27	fact	fact	NOUN
ijpds-3217	119	28	that	that	SCONJ
ijpds-3217	119	29	glu	glu	NOUN
ijpds-3217	119	30	is	be	AUX
ijpds-3217	119	31	in	in	ADP
ijpds-3217	119	32	its	its	PRON
ijpds-3217	119	33	pyranose	pyranose	NOUN
ijpds-3217	119	34	form	form	NOUN
ijpds-3217	119	35	.	.	PUNCT
ijpds-3217	120	1	according	accord	VERB
ijpds-3217	120	2	to	to	ADP
ijpds-3217	120	3	the	the	DET
ijpds-3217	120	4	molecular	molecular	ADJ
ijpds-3217	120	5	docking	docking	NOUN
ijpds-3217	120	6	analysis	analysis	NOUN
ijpds-3217	120	7	(	(	PUNCT
ijpds-3217	120	8	figure	figure	NOUN
ijpds-3217	120	9	3	3	NUM
ijpds-3217	120	10	and	and	CCONJ
ijpds-3217	120	11	table	table	NOUN
ijpds-3217	120	12	3	3	NUM
ijpds-3217	120	13	)	)	PUNCT
ijpds-3217	120	14	,	,	PUNCT
ijpds-3217	120	15	hydrogen	hydrogen	NOUN
ijpds-3217	120	16	bonding	bonding	NOUN
ijpds-3217	120	17	and	and	CCONJ
ijpds-3217	120	18	van	van	PROPN
ijpds-3217	120	19	der	der	NOUN
ijpds-3217	120	20	waals	waal	NOUN
ijpds-3217	120	21	interactions	interaction	NOUN
ijpds-3217	120	22	are	be	AUX
ijpds-3217	120	23	the	the	DET
ijpds-3217	120	24	main	main	ADJ
ijpds-3217	120	25	intermolecular	intermolecular	ADJ
ijpds-3217	120	26	forces	force	NOUN
ijpds-3217	120	27	involved	involve	VERB
ijpds-3217	120	28	in	in	ADP
ijpds-3217	120	29	hsa	hsa	PROPN
ijpds-3217	120	30	-	-	PUNCT
ijpds-3217	120	31	hctz	hctz	PROPN
ijpds-3217	120	32	,	,	PUNCT
ijpds-3217	120	33	hsa	hsa	PROPN
ijpds-3217	120	34	-	-	PUNCT
ijpds-3217	120	35	glu	glu	NOUN
ijpds-3217	120	36	,	,	PUNCT
ijpds-3217	120	37	and	and	CCONJ
ijpds-3217	120	38	hsa-glu.hctz	hsa-glu.hctz	ADJ
ijpds-3217	120	39	interactions	interaction	NOUN
ijpds-3217	120	40	(	(	PUNCT
ijpds-3217	120	41	for	for	ADP
ijpds-3217	120	42	both	both	CCONJ
ijpds-3217	120	43	open	open	ADJ
ijpds-3217	120	44	and	and	CCONJ
ijpds-3217	120	45	cyclic	cyclic	ADJ
ijpds-3217	120	46	forms	form	NOUN
ijpds-3217	120	47	of	of	ADP
ijpds-3217	120	48	glu	glu	NOUN
ijpds-3217	120	49	)	)	PUNCT
ijpds-3217	120	50	.	.	PUNCT
ijpds-3217	121	1	as	as	ADP
ijpds-3217	121	2	an	an	DET
ijpds-3217	121	3	example	example	NOUN
ijpds-3217	121	4	,	,	PUNCT
ijpds-3217	121	5	the	the	DET
ijpds-3217	121	6	hydrogen	hydrogen	NOUN
ijpds-3217	121	7	atom	atom	NOUN
ijpds-3217	121	8	of	of	ADP
ijpds-3217	121	9	the	the	DET
ijpds-3217	121	10	-nh3	-nh3	PROPN
ijpds-3217	121	11	+	+	NUM
ijpds-3217	121	12	group	group	NOUN
ijpds-3217	121	13	of	of	ADP
ijpds-3217	121	14	lys194	lys194	PROPN
ijpds-3217	121	15	,	,	PUNCT
ijpds-3217	121	16	lys-198	lys-198	NOUN
ijpds-3217	121	17	,	,	PUNCT
ijpds-3217	121	18	and	and	CCONJ
ijpds-3217	121	19	lys-443	lys-443	NOUN
ijpds-3217	121	20	residues	residue	NOUN
ijpds-3217	121	21	is	be	AUX
ijpds-3217	121	22	a	a	DET
ijpds-3217	121	23	potential	potential	ADJ
ijpds-3217	121	24	donor	donor	NOUN
ijpds-3217	121	25	for	for	ADP
ijpds-3217	121	26	hydrogen	hydrogen	NOUN
ijpds-3217	121	27	bonding	bonding	NOUN
ijpds-3217	121	28	with	with	ADP
ijpds-3217	121	29	the	the	DET
ijpds-3217	121	30	sulfonamide	sulfonamide	NOUN
ijpds-3217	121	31	group	group	NOUN
ijpds-3217	121	32	of	of	ADP
ijpds-3217	121	33	hctz	hctz	PROPN
ijpds-3217	121	34	at	at	ADP
ijpds-3217	121	35	distances	distance	NOUN
ijpds-3217	121	36	of	of	ADP
ijpds-3217	121	37	2.10	2.10	NUM
ijpds-3217	121	38	,	,	PUNCT
ijpds-3217	121	39	3.50	3.50	NUM
ijpds-3217	121	40	,	,	PUNCT
ijpds-3217	121	41	and	and	CCONJ
ijpds-3217	121	42	3.70	3.70	NUM
ijpds-3217	121	43	å	å	NOUN
ijpds-3217	121	44	,	,	PUNCT
ijpds-3217	121	45	respectively	respectively	ADV
ijpds-3217	121	46	.	.	PUNCT
ijpds-3217	122	1	on	on	ADP
ijpds-3217	122	2	the	the	DET
ijpds-3217	122	3	other	other	ADJ
ijpds-3217	122	4	hand	hand	NOUN
ijpds-3217	122	5	,	,	PUNCT
ijpds-3217	122	6	the	the	DET
ijpds-3217	122	7	oxygen	oxygen	NOUN
ijpds-3217	122	8	atom	atom	NOUN
ijpds-3217	122	9	of	of	ADP
ijpds-3217	122	10	gln-220	gln-220	NOUN
ijpds-3217	122	11	,	,	PUNCT
ijpds-3217	122	12	glu-449	glu-449	PROPN
ijpds-3217	122	13	,	,	PUNCT
ijpds-3217	122	14	and	and	CCONJ
ijpds-3217	122	15	asp450	asp450	ADJ
ijpds-3217	122	16	residues	residue	NOUN
ijpds-3217	122	17	is	be	AUX
ijpds-3217	122	18	a	a	DET
ijpds-3217	122	19	potential	potential	ADJ
ijpds-3217	122	20	acceptor	acceptor	NOUN
ijpds-3217	122	21	for	for	ADP
ijpds-3217	122	22	hydrogen	hydrogen	NOUN
ijpds-3217	122	23	bonding	bonding	NOUN
ijpds-3217	122	24	with	with	ADP
ijpds-3217	122	25	the	the	DET
ijpds-3217	122	26	nh	nh	NOUN
ijpds-3217	122	27	-	-	PUNCT
ijpds-3217	122	28	portion	portion	NOUN
ijpds-3217	122	29	of	of	ADP
ijpds-3217	122	30	the	the	DET
ijpds-3217	122	31	hctz	hctz	PROPN
ijpds-3217	122	32	structure	structure	NOUN
ijpds-3217	122	33	at	at	ADP
ijpds-3217	122	34	distances	distance	NOUN
ijpds-3217	122	35	of	of	ADP
ijpds-3217	122	36	2.10	2.10	NUM
ijpds-3217	122	37	,	,	PUNCT
ijpds-3217	122	38	1.60	1.60	NUM
ijpds-3217	122	39	,	,	PUNCT
ijpds-3217	122	40	and	and	CCONJ
ijpds-3217	122	41	1.60	1.60	NUM
ijpds-3217	122	42	å	å	NOUN
ijpds-3217	122	43	,	,	PUNCT
ijpds-3217	122	44	respectively	respectively	ADV
ijpds-3217	122	45	.	.	PUNCT
ijpds-3217	123	1	in	in	ADP
ijpds-3217	123	2	addition	addition	NOUN
ijpds-3217	123	3	,	,	PUNCT
ijpds-3217	123	4	the	the	DET
ijpds-3217	123	5	amino	amino	NOUN
ijpds-3217	123	6	acid	acid	NOUN
ijpds-3217	123	7	residue	residue	NOUN
ijpds-3217	123	8	arg221	arg221	NOUN
ijpds-3217	123	9	also	also	ADV
ijpds-3217	123	10	interacts	interact	VERB
ijpds-3217	123	11	with	with	ADP
ijpds-3217	123	12	the	the	DET
ijpds-3217	123	13	sulfonamide	sulfonamide	NOUN
ijpds-3217	123	14	group	group	NOUN
ijpds-3217	123	15	of	of	ADP
ijpds-3217	123	16	hctz	hctz	PROPN
ijpds-3217	123	17	via	via	ADP
ijpds-3217	123	18	hydrogen	hydrogen	NOUN
ijpds-3217	123	19	bonding	bonding	NOUN
ijpds-3217	123	20	at	at	ADP
ijpds-3217	123	21	a	a	DET
ijpds-3217	123	22	distance	distance	NOUN
ijpds-3217	123	23	of	of	ADP
ijpds-3217	123	24	1.80	1.80	NUM
ijpds-3217	123	25	å	å	NOUN
ijpds-3217	123	26	.	.	PUNCT
ijpds-3217	124	1	finally	finally	ADV
ijpds-3217	124	2	,	,	PUNCT
ijpds-3217	124	3	van	van	PROPN
ijpds-3217	124	4	der	der	NOUN
ijpds-3217	124	5	waals	waal	NOUN
ijpds-3217	124	6	interactions	interaction	NOUN
ijpds-3217	124	7	between	between	ADP
ijpds-3217	124	8	hctz	hctz	NOUN
ijpds-3217	124	9	and	and	CCONJ
ijpds-3217	124	10	amino	amino	NOUN
ijpds-3217	124	11	acid	acid	NOUN
ijpds-3217	124	12	residues	residue	NOUN
ijpds-3217	124	13	trp-214	trp-214	NOUN
ijpds-3217	124	14	and	and	CCONJ
ijpds-3217	124	15	val-342	val-342	NOUN
ijpds-3217	124	16	at	at	ADP
ijpds-3217	124	17	distances	distance	NOUN
ijpds-3217	124	18	of	of	ADP
ijpds-3217	124	19	3.10	3.10	NUM
ijpds-3217	124	20	and	and	CCONJ
ijpds-3217	124	21	2.80	2.80	NUM
ijpds-3217	124	22	å	å	NOUN
ijpds-3217	124	23	,	,	PUNCT
ijpds-3217	124	24	respectively	respectively	ADV
ijpds-3217	124	25	,	,	PUNCT
ijpds-3217	124	26	have	have	AUX
ijpds-3217	124	27	also	also	ADV
ijpds-3217	124	28	been	be	AUX
ijpds-3217	124	29	observed	observe	VERB
ijpds-3217	124	30	.	.	PUNCT
ijpds-3217	125	1	figure	figure	NOUN
ijpds-3217	125	2	3	3	NUM
ijpds-3217	125	3	(	(	PUNCT
ijpds-3217	125	4	a	a	X
ijpds-3217	125	5	)	)	PUNCT
ijpds-3217	125	6	best	good	ADJ
ijpds-3217	125	7	docking	docking	NOUN
ijpds-3217	125	8	poses	pose	NOUN
ijpds-3217	125	9	for	for	ADP
ijpds-3217	125	10	the	the	DET
ijpds-3217	125	11	interaction	interaction	NOUN
ijpds-3217	125	12	of	of	ADP
ijpds-3217	125	13	hsa	hsa	PROPN
ijpds-3217	125	14	-	-	PUNCT
ijpds-3217	125	15	hctz	hctz	PROPN
ijpds-3217	125	16	at	at	ADP
ijpds-3217	125	17	sites	site	NOUN
ijpds-3217	125	18	i	i	PRON
ijpds-3217	125	19	,	,	PUNCT
ijpds-3217	125	20	ii	ii	PROPN
ijpds-3217	125	21	,	,	PUNCT
ijpds-3217	125	22	and	and	CCONJ
ijpds-3217	125	23	iii	iii	X
ijpds-3217	125	24	.	.	PUNCT
ijpds-3217	126	1	the	the	DET
ijpds-3217	126	2	zoom	zoom	NOUN
ijpds-3217	126	3	representation	representation	NOUN
ijpds-3217	126	4	shows	show	VERB
ijpds-3217	126	5	the	the	DET
ijpds-3217	126	6	main	main	ADJ
ijpds-3217	126	7	amino	amino	NOUN
ijpds-3217	126	8	acid	acid	NOUN
ijpds-3217	126	9	residues	residue	NOUN
ijpds-3217	126	10	involved	involve	VERB
ijpds-3217	126	11	in	in	ADP
ijpds-3217	126	12	the	the	DET
ijpds-3217	126	13	interaction	interaction	NOUN
ijpds-3217	126	14	hsa	hsa	PROPN
ijpds-3217	126	15	-	-	PUNCT
ijpds-3217	126	16	hctz	hctz	PROPN
ijpds-3217	126	17	at	at	ADP
ijpds-3217	126	18	a	a	DET
ijpds-3217	126	19	site	site	NOUN
ijpds-3217	126	20	i.	i.	NOUN
ijpds-3217	126	21	best	good	ADJ
ijpds-3217	126	22	docking	docking	NOUN
ijpds-3217	126	23	pose	pose	VERB
ijpds-3217	126	24	for	for	ADP
ijpds-3217	126	25	the	the	DET
ijpds-3217	126	26	interaction	interaction	NOUN
ijpds-3217	126	27	between	between	ADP
ijpds-3217	126	28	hsaglucose	hsaglucose	NOUN
ijpds-3217	126	29	(	(	PUNCT
ijpds-3217	126	30	b	b	NOUN
ijpds-3217	126	31	)	)	PUNCT
ijpds-3217	126	32	and	and	CCONJ
ijpds-3217	126	33	hsa-glu.hctz	hsa-glu.hctz	ADV
ijpds-3217	126	34	(	(	PUNCT
ijpds-3217	126	35	c	c	NOUN
ijpds-3217	126	36	)	)	PUNCT
ijpds-3217	126	37	,	,	PUNCT
ijpds-3217	126	38	respectively	respectively	ADV
ijpds-3217	126	39	for	for	ADP
ijpds-3217	126	40	glucose	glucose	NOUN
ijpds-3217	126	41	in	in	ADP
ijpds-3217	126	42	the	the	DET
ijpds-3217	126	43	open	open	ADJ
ijpds-3217	126	44	form	form	NOUN
ijpds-3217	126	45	at	at	ADP
ijpds-3217	126	46	a	a	DET
ijpds-3217	126	47	site	site	NOUN
ijpds-3217	126	48	i.	i.	NOUN
ijpds-3217	126	49	best	good	ADJ
ijpds-3217	126	50	docking	docking	NOUN
ijpds-3217	126	51	pose	pose	VERB
ijpds-3217	126	52	for	for	ADP
ijpds-3217	126	53	the	the	DET
ijpds-3217	126	54	interaction	interaction	NOUN
ijpds-3217	126	55	between	between	ADP
ijpds-3217	126	56	hsa	hsa	PROPN
ijpds-3217	126	57	-	-	PUNCT
ijpds-3217	126	58	glucose	glucose	NOUN
ijpds-3217	126	59	(	(	PUNCT
ijpds-3217	126	60	d	d	NOUN
ijpds-3217	126	61	)	)	PUNCT
ijpds-3217	126	62	and	and	CCONJ
ijpds-3217	126	63	hsa-glu.hctz	hsa-glu.hctz	ADV
ijpds-3217	126	64	(	(	PUNCT
ijpds-3217	126	65	e	e	NOUN
ijpds-3217	126	66	)	)	PUNCT
ijpds-3217	126	67	,	,	PUNCT
ijpds-3217	126	68	respectively	respectively	ADV
ijpds-3217	126	69	for	for	ADP
ijpds-3217	126	70	glucose	glucose	NOUN
ijpds-3217	126	71	in	in	ADP
ijpds-3217	126	72	the	the	DET
ijpds-3217	126	73	cyclic	cyclic	ADJ
ijpds-3217	126	74	form	form	NOUN
ijpds-3217	126	75	at	at	ADP
ijpds-3217	126	76	the	the	DET
ijpds-3217	126	77	site	site	NOUN
ijpds-3217	126	78	i.	i.	PROPN
ijpds-3217	126	79	amino	amino	PROPN
ijpds-3217	126	80	acid	acid	NOUN
ijpds-3217	126	81	residues	residue	NOUN
ijpds-3217	126	82	,	,	PUNCT
ijpds-3217	126	83	hctz	hctz	NOUN
ijpds-3217	126	84	,	,	PUNCT
ijpds-3217	126	85	and	and	CCONJ
ijpds-3217	126	86	glucose	glucose	NOUN
ijpds-3217	126	87	in	in	ADP
ijpds-3217	126	88	the	the	DET
ijpds-3217	126	89	open	open	ADJ
ijpds-3217	126	90	and	and	CCONJ
ijpds-3217	126	91	cyclic	cyclic	ADJ
ijpds-3217	126	92	forms	form	NOUN
ijpds-3217	126	93	are	be	AUX
ijpds-3217	126	94	in	in	ADP
ijpds-3217	126	95	cyan	cyan	ADJ
ijpds-3217	126	96	,	,	PUNCT
ijpds-3217	126	97	purple	purple	ADJ
ijpds-3217	126	98	,	,	PUNCT
ijpds-3217	126	99	beige	beige	ADJ
ijpds-3217	126	100	and	and	CCONJ
ijpds-3217	126	101	orange	orange	NOUN
ijpds-3217	126	102	colors	color	NOUN
ijpds-3217	126	103	,	,	PUNCT
ijpds-3217	126	104	respectively	respectively	ADV
ijpds-3217	126	105	.	.	PUNCT
ijpds-3217	127	1	hydrogen	hydrogen	NOUN
ijpds-3217	127	2	,	,	PUNCT
ijpds-3217	127	3	oxygen	oxygen	NOUN
ijpds-3217	127	4	,	,	PUNCT
ijpds-3217	127	5	nitrogen	nitrogen	NOUN
ijpds-3217	127	6	,	,	PUNCT
ijpds-3217	127	7	chloro	chloro	NOUN
ijpds-3217	127	8	,	,	PUNCT
ijpds-3217	127	9	and	and	CCONJ
ijpds-3217	127	10	sulfur	sulfur	NOUN
ijpds-3217	127	11	are	be	AUX
ijpds-3217	127	12	in	in	ADP
ijpds-3217	127	13	white	white	ADJ
ijpds-3217	127	14	,	,	PUNCT
ijpds-3217	127	15	red	red	ADJ
ijpds-3217	127	16	,	,	PUNCT
ijpds-3217	127	17	dark	dark	ADJ
ijpds-3217	127	18	blue	blue	NOUN
ijpds-3217	127	19	,	,	PUNCT
ijpds-3217	127	20	green	green	ADJ
ijpds-3217	127	21	,	,	PUNCT
ijpds-3217	127	22	and	and	CCONJ
ijpds-3217	127	23	yellow	yellow	ADJ
ijpds-3217	127	24	,	,	PUNCT
ijpds-3217	127	25	respectively	respectively	ADV
ijpds-3217	127	26	.	.	PUNCT
ijpds-3217	128	1	soares	soares	PROPN
ijpds-3217	128	2	et	et	PROPN
ijpds-3217	128	3	al	al	PROPN
ijpds-3217	128	4	hsa	hsa	PROPN
ijpds-3217	128	5	-	-	PUNCT
ijpds-3217	128	6	hctz	hctz	ADJ
ijpds-3217	128	7	interactions	interaction	NOUN
ijpds-3217	128	8	based	base	VERB
ijpds-3217	128	9	on	on	ADP
ijpds-3217	128	10	glucose	glucose	NOUN
ijpds-3217	128	11	concentrations	concentration	NOUN
ijpds-3217	128	12	vol	vol	NOUN
ijpds-3217	128	13	1	1	NUM
ijpds-3217	128	14	|	|	NOUN
ijpds-3217	128	15	issue	issue	NOUN
ijpds-3217	128	16	2	2	NUM
ijpds-3217	129	1	|	|	ADV
ijpds-3217	129	2	jul	jul	PROPN
ijpds-3217	129	3	sep	sep	PROPN
ijpds-3217	129	4	2022	2022	NUM
ijpds-3217	129	5	indian	indian	PROPN
ijpds-3217	129	6	j	j	PROPN
ijpds-3217	129	7	pharm	pharm	PROPN
ijpds-3217	129	8	drug	drug	PROPN
ijpds-3217	129	9	studies	study	NOUN
ijpds-3217	129	10	|	|	ADV
ijpds-3217	129	11	61	61	NUM
ijpds-3217	129	12	conclusion	conclusion	NOUN
ijpds-3217	129	13	circular	circular	ADJ
ijpds-3217	129	14	dichroism	dichroism	NOUN
ijpds-3217	129	15	confirms	confirm	VERB
ijpds-3217	129	16	the	the	DET
ijpds-3217	129	17	decrease	decrease	NOUN
ijpds-3217	129	18	in	in	ADP
ijpds-3217	129	19	the	the	DET
ijpds-3217	129	20	binding	bind	VERB
ijpds-3217	129	21	ability	ability	NOUN
ijpds-3217	129	22	of	of	ADP
ijpds-3217	129	23	hctz	hctz	NOUN
ijpds-3217	129	24	to	to	ADP
ijpds-3217	129	25	albumin	albumin	NOUN
ijpds-3217	129	26	with	with	ADP
ijpds-3217	129	27	an	an	DET
ijpds-3217	129	28	increase	increase	NOUN
ijpds-3217	129	29	in	in	ADP
ijpds-3217	129	30	glu	glu	NOUN
ijpds-3217	129	31	concentration	concentration	NOUN
ijpds-3217	129	32	due	due	ADP
ijpds-3217	129	33	to	to	ADP
ijpds-3217	129	34	the	the	DET
ijpds-3217	129	35	perturbation	perturbation	NOUN
ijpds-3217	129	36	of	of	ADP
ijpds-3217	129	37	the	the	DET
ijpds-3217	129	38	albumin	albumin	ADJ
ijpds-3217	129	39	structure	structure	NOUN
ijpds-3217	129	40	.	.	PUNCT
ijpds-3217	130	1	the	the	DET
ijpds-3217	130	2	binding	bind	VERB
ijpds-3217	130	3	hctz	hctz	NOUN
ijpds-3217	130	4	-	-	PUNCT
ijpds-3217	130	5	hsa	hsa	PROPN
ijpds-3217	130	6	is	be	AUX
ijpds-3217	130	7	spontaneous	spontaneous	ADJ
ijpds-3217	130	8	and	and	CCONJ
ijpds-3217	130	9	causes	cause	VERB
ijpds-3217	130	10	weak	weak	ADJ
ijpds-3217	130	11	perturbation	perturbation	NOUN
ijpds-3217	130	12	on	on	ADP
ijpds-3217	130	13	the	the	DET
ijpds-3217	130	14	secondary	secondary	ADJ
ijpds-3217	130	15	and	and	CCONJ
ijpds-3217	130	16	tertiary	tertiary	ADJ
ijpds-3217	130	17	structure	structure	NOUN
ijpds-3217	130	18	of	of	ADP
ijpds-3217	130	19	albumin	albumin	NOUN
ijpds-3217	130	20	,	,	PUNCT
ijpds-3217	130	21	however	however	ADV
ijpds-3217	130	22	,	,	PUNCT
ijpds-3217	130	23	at	at	ADP
ijpds-3217	130	24	high	high	ADJ
ijpds-3217	130	25	glu	glu	NOUN
ijpds-3217	130	26	concentration	concentration	NOUN
ijpds-3217	130	27	,	,	PUNCT
ijpds-3217	130	28	it	it	PRON
ijpds-3217	130	29	was	be	AUX
ijpds-3217	130	30	observed	observe	VERB
ijpds-3217	130	31	an	an	DET
ijpds-3217	130	32	increase	increase	NOUN
ijpds-3217	130	33	of	of	ADP
ijpds-3217	130	34	perturbation	perturbation	NOUN
ijpds-3217	130	35	on	on	ADP
ijpds-3217	130	36	these	these	DET
ijpds-3217	130	37	structures	structure	NOUN
ijpds-3217	130	38	increases	increase	NOUN
ijpds-3217	130	39	,	,	PUNCT
ijpds-3217	130	40	conducting	conduct	VERB
ijpds-3217	130	41	the	the	DET
ijpds-3217	130	42	albumin	albumin	ADJ
ijpds-3217	130	43	structure	structure	NOUN
ijpds-3217	130	44	to	to	ADP
ijpds-3217	130	45	an	an	DET
ijpds-3217	130	46	instability	instability	NOUN
ijpds-3217	130	47	condition	condition	NOUN
ijpds-3217	130	48	and	and	CCONJ
ijpds-3217	130	49	difficulty	difficulty	NOUN
ijpds-3217	130	50	the	the	DET
ijpds-3217	130	51	bind	bind	NOUN
ijpds-3217	130	52	of	of	ADP
ijpds-3217	130	53	hctz	hctz	NOUN
ijpds-3217	130	54	to	to	ADP
ijpds-3217	130	55	the	the	DET
ijpds-3217	130	56	protein	protein	NOUN
ijpds-3217	130	57	binding	bind	VERB
ijpds-3217	130	58	pocket	pocket	NOUN
ijpds-3217	130	59	.	.	PUNCT
ijpds-3217	131	1	there	there	PRON
ijpds-3217	131	2	is	be	VERB
ijpds-3217	131	3	just	just	ADV
ijpds-3217	131	4	one	one	NUM
ijpds-3217	131	5	primary	primary	ADJ
ijpds-3217	131	6	binding	bind	VERB
ijpds-3217	131	7	site	site	NOUN
ijpds-3217	131	8	for	for	ADP
ijpds-3217	131	9	hctz	hctz	NOUN
ijpds-3217	131	10	in	in	ADP
ijpds-3217	131	11	subdomain	subdomain	NOUN
ijpds-3217	131	12	iia	iia	NOUN
ijpds-3217	131	13	(	(	PUNCT
ijpds-3217	131	14	the	the	DET
ijpds-3217	131	15	site	site	NOUN
ijpds-3217	131	16	i	i	PROPN
ijpds-3217	131	17	)	)	PUNCT
ijpds-3217	131	18	,	,	PUNCT
ijpds-3217	131	19	and	and	CCONJ
ijpds-3217	131	20	in	in	ADP
ijpds-3217	131	21	this	this	DET
ijpds-3217	131	22	binding	bind	VERB
ijpds-3217	131	23	pocket	pocket	NOUN
ijpds-3217	131	24	of	of	ADP
ijpds-3217	131	25	hsa	hsa	PROPN
ijpds-3217	131	26	,	,	PUNCT
ijpds-3217	131	27	hydrogen	hydrogen	NOUN
ijpds-3217	131	28	bonding	bonding	NOUN
ijpds-3217	131	29	and	and	CCONJ
ijpds-3217	131	30	van	van	PROPN
ijpds-3217	131	31	der	der	NOUN
ijpds-3217	131	32	waals	waal	NOUN
ijpds-3217	131	33	interactions	interaction	NOUN
ijpds-3217	131	34	as	as	ADP
ijpds-3217	131	35	the	the	DET
ijpds-3217	131	36	key	key	ADJ
ijpds-3217	131	37	forces	force	NOUN
ijpds-3217	131	38	for	for	ADP
ijpds-3217	131	39	the	the	DET
ijpds-3217	131	40	association	association	NOUN
ijpds-3217	131	41	.	.	PUNCT
ijpds-3217	132	1	overall	overall	ADV
ijpds-3217	132	2	,	,	PUNCT
ijpds-3217	132	3	the	the	DET
ijpds-3217	132	4	experimental	experimental	ADJ
ijpds-3217	132	5	and	and	CCONJ
ijpds-3217	132	6	theoretical	theoretical	ADJ
ijpds-3217	132	7	results	result	NOUN
ijpds-3217	132	8	suggest	suggest	VERB
ijpds-3217	132	9	that	that	SCONJ
ijpds-3217	132	10	the	the	DET
ijpds-3217	132	11	increase	increase	NOUN
ijpds-3217	132	12	in	in	ADP
ijpds-3217	132	13	the	the	DET
ijpds-3217	132	14	blood	blood	NOUN
ijpds-3217	132	15	glu	glu	NOUN
ijpds-3217	132	16	level	level	NOUN
ijpds-3217	132	17	can	can	AUX
ijpds-3217	132	18	cause	cause	VERB
ijpds-3217	132	19	functional	functional	ADJ
ijpds-3217	132	20	perturbation	perturbation	NOUN
ijpds-3217	132	21	in	in	ADP
ijpds-3217	132	22	the	the	DET
ijpds-3217	132	23	ability	ability	NOUN
ijpds-3217	132	24	of	of	ADP
ijpds-3217	132	25	hctz	hctz	NOUN
ijpds-3217	132	26	to	to	PART
ijpds-3217	132	27	bind	bind	VERB
ijpds-3217	132	28	to	to	ADP
ijpds-3217	132	29	albumin	albumin	NOUN
ijpds-3217	132	30	.	.	PUNCT
ijpds-3217	133	1	it	it	PRON
ijpds-3217	133	2	suggests	suggest	VERB
ijpds-3217	133	3	that	that	SCONJ
ijpds-3217	133	4	the	the	DET
ijpds-3217	133	5	adverse	adverse	ADJ
ijpds-3217	133	6	effects	effect	NOUN
ijpds-3217	133	7	of	of	ADP
ijpds-3217	133	8	hctz	hctz	NOUN
ijpds-3217	133	9	in	in	ADP
ijpds-3217	133	10	hyperglycemic	hyperglycemic	ADJ
ijpds-3217	133	11	patients	patient	NOUN
ijpds-3217	133	12	may	may	AUX
ijpds-3217	133	13	be	be	AUX
ijpds-3217	133	14	related	relate	VERB
ijpds-3217	133	15	to	to	ADP
ijpds-3217	133	16	increased	increase	VERB
ijpds-3217	133	17	levels	level	NOUN
ijpds-3217	133	18	of	of	ADP
ijpds-3217	133	19	free	free	ADJ
ijpds-3217	133	20	drug	drug	NOUN
ijpds-3217	133	21	in	in	ADP
ijpds-3217	133	22	the	the	DET
ijpds-3217	133	23	bloodstream	bloodstream	NOUN
ijpds-3217	133	24	by	by	ADP
ijpds-3217	133	25	the	the	DET
ijpds-3217	133	26	decrease	decrease	NOUN
ijpds-3217	133	27	of	of	ADP
ijpds-3217	133	28	its	its	PRON
ijpds-3217	133	29	binding	binding	NOUN
ijpds-3217	133	30	to	to	ADP
ijpds-3217	133	31	albumin	albumin	NOUN
ijpds-3217	133	32	.	.	PUNCT
ijpds-3217	134	1	in	in	ADP
ijpds-3217	134	2	this	this	DET
ijpds-3217	134	3	way	way	NOUN
ijpds-3217	134	4	,	,	PUNCT
ijpds-3217	134	5	effective	effective	ADJ
ijpds-3217	134	6	treatment	treatment	NOUN
ijpds-3217	134	7	for	for	ADP
ijpds-3217	134	8	diabetic	diabetic	ADJ
ijpds-3217	134	9	patients	patient	NOUN
ijpds-3217	134	10	with	with	ADP
ijpds-3217	134	11	hctz	hctz	PROPN
ijpds-3217	134	12	is	be	AUX
ijpds-3217	134	13	linked	link	VERB
ijpds-3217	134	14	to	to	ADP
ijpds-3217	134	15	adequate	adequate	ADJ
ijpds-3217	134	16	control	control	NOUN
ijpds-3217	134	17	of	of	ADP
ijpds-3217	134	18	the	the	DET
ijpds-3217	134	19	glycemic	glycemic	ADJ
ijpds-3217	134	20	index	index	NOUN
ijpds-3217	134	21	.	.	PUNCT
ijpds-3217	135	1	references	reference	NOUN
ijpds-3217	135	2	1	1	NUM
ijpds-3217	135	3	.	.	PUNCT
ijpds-3217	135	4	soares	soares	PROPN
ijpds-3217	135	5	m.a.g	m.a.g	PROPN
ijpds-3217	135	6	.	.	PROPN
ijpds-3217	135	7	,	,	PUNCT
ijpds-3217	135	8	chaves	chaves	PROPN
ijpds-3217	135	9	o.a	o.a	PROPN
ijpds-3217	135	10	.	.	PROPN
ijpds-3217	135	11	,	,	PUNCT
ijpds-3217	135	12	cesarin	cesarin	NOUN
ijpds-3217	135	13	-	-	PUNCT
ijpds-3217	135	14	sobrinho	sobrinho	PROPN
ijpds-3217	135	15	d.	d.	PROPN
ijpds-3217	135	16	,	,	PUNCT
ijpds-3217	135	17	et	et	PROPN
ijpds-3217	135	18	al	al	PROPN
ijpds-3217	135	19	.	.	PROPN
ijpds-3217	135	20	effect	effect	NOUN
ijpds-3217	135	21	of	of	ADP
ijpds-3217	135	22	blood	blood	NOUN
ijpds-3217	135	23	glucose	glucose	NOUN
ijpds-3217	135	24	levels	level	NOUN
ijpds-3217	135	25	on	on	ADP
ijpds-3217	135	26	the	the	DET
ijpds-3217	135	27	hs	hs	PROPN
ijpds-3217	135	28	ahydrochlorothiazide	ahydrochlorothiazide	PROPN
ijpds-3217	135	29	interaction	interaction	NOUN
ijpds-3217	135	30	a	a	DET
ijpds-3217	135	31	spectrofluorimetric	spectrofluorimetric	ADJ
ijpds-3217	135	32	study	study	NOUN
ijpds-3217	135	33	.	.	PUNCT
ijpds-3217	136	1	int	int	PROPN
ijpds-3217	136	2	j	j	PROPN
ijpds-3217	136	3	health	health	PROPN
ijpds-3217	136	4	sci	sci	PROPN
ijpds-3217	136	5	.	.	PROPN
ijpds-3217	136	6	2021	2021	NUM
ijpds-3217	136	7	;	;	PUNCT
ijpds-3217	136	8	1(3):1	1(3):1	NUM
ijpds-3217	136	9	-	-	SYM
ijpds-3217	136	10	5	5	NUM
ijpds-3217	136	11	.	.	PUNCT
ijpds-3217	136	12	doi	doi	PROPN
ijpds-3217	136	13	https://www.atenaeditora.com.br/post-artigo/59467	https://www.atenaeditora.com.br/post-artigo/59467	PROPN
ijpds-3217	136	14	.	.	PROPN
ijpds-3217	137	1	2	2	NUM
ijpds-3217	137	2	.	.	X
ijpds-3217	137	3	shrivastva	shrivastva	PROPN
ijpds-3217	137	4	a	a	PROPN
ijpds-3217	137	5	,	,	PUNCT
ijpds-3217	137	6	phadnis	phadnis	NOUN
ijpds-3217	137	7	s	s	PART
ijpds-3217	137	8	,	,	PUNCT
ijpds-3217	137	9	karthik	karthik	PROPN
ijpds-3217	137	10	rao	rao	PROPN
ijpds-3217	137	11	n	n	CCONJ
ijpds-3217	137	12	,	,	PUNCT
ijpds-3217	137	13	et	et	PROPN
ijpds-3217	137	14	al	al	PROPN
ijpds-3217	137	15	.	.	PUNCT
ijpds-3217	138	1	a	a	DET
ijpds-3217	138	2	study	study	NOUN
ijpds-3217	138	3	on	on	ADP
ijpds-3217	138	4	knowledge	knowledge	NOUN
ijpds-3217	138	5	and	and	CCONJ
ijpds-3217	138	6	self	self	NOUN
ijpds-3217	138	7	-	-	PUNCT
ijpds-3217	138	8	care	care	NOUN
ijpds-3217	138	9	practices	practice	NOUN
ijpds-3217	138	10	about	about	ADP
ijpds-3217	138	11	diabetes	diabetes	NOUN
ijpds-3217	138	12	mellitus	mellitus	NOUN
ijpds-3217	138	13	among	among	ADP
ijpds-3217	138	14	patients	patient	NOUN
ijpds-3217	138	15	with	with	ADP
ijpds-3217	138	16	type	type	NOUN
ijpds-3217	138	17	2	2	NUM
ijpds-3217	138	18	diabetes	diabetes	NOUN
ijpds-3217	138	19	mellitus	mellitus	NOUN
ijpds-3217	138	20	attending	attend	VERB
ijpds-3217	138	21	selected	select	VERB
ijpds-3217	138	22	tertiary	tertiary	ADJ
ijpds-3217	138	23	healthcare	healthcare	NOUN
ijpds-3217	138	24	facilities	facility	NOUN
ijpds-3217	138	25	in	in	ADP
ijpds-3217	138	26	coastal	coastal	ADJ
ijpds-3217	138	27	karnataka	karnataka	PROPN
ijpds-3217	138	28	.	.	PUNCT
ijpds-3217	139	1	clin	clin	PROPN
ijpds-3217	139	2	.	.	PUNCT
ijpds-3217	140	1	epidemiol	epidemiol	PROPN
ijpds-3217	140	2	glob	glob	PROPN
ijpds-3217	140	3	health	health	NOUN
ijpds-3217	140	4	.	.	PUNCT
ijpds-3217	141	1	2020	2020	NUM
ijpds-3217	141	2	;	;	PUNCT
ijpds-3217	141	3	8	8	NUM
ijpds-3217	141	4	:	:	SYM
ijpds-3217	141	5	689	689	NUM
ijpds-3217	141	6	692	692	NUM
ijpds-3217	141	7	.	.	PUNCT
ijpds-3217	142	1	3	3	X
ijpds-3217	142	2	.	.	X
ijpds-3217	142	3	fu	fu	PROPN
ijpds-3217	143	1	x	x	PROPN
ijpds-3217	143	2	,	,	PUNCT
ijpds-3217	143	3	nan	nan	PROPN
ijpds-3217	143	4	h	h	PROPN
ijpds-3217	143	5	,	,	PUNCT
ijpds-3217	143	6	liu	liu	PROPN
ijpds-3217	143	7	z	z	PROPN
ijpds-3217	143	8	,	,	PUNCT
ijpds-3217	143	9	et	et	PROPN
ijpds-3217	143	10	al	al	PROPN
ijpds-3217	143	11	.	.	PROPN
ijpds-3217	143	12	association	association	PROPN
ijpds-3217	143	13	of	of	ADP
ijpds-3217	143	14	nad+	nad+	PROPN
ijpds-3217	143	15	ad	ad	NOUN
ijpds-3217	143	16	pribosyl	pribosyl	NOUN
ijpds-3217	143	17	transferase	transferase	NOUN
ijpds-3217	143	18	1	1	NUM
ijpds-3217	143	19	gene	gene	NOUN
ijpds-3217	143	20	polymorphism	polymorphism	NOUN
ijpds-3217	143	21	with	with	ADP
ijpds-3217	143	22	the	the	DET
ijpds-3217	143	23	development	development	NOUN
ijpds-3217	143	24	of	of	ADP
ijpds-3217	143	25	neonatal	neonatal	ADJ
ijpds-3217	143	26	diabetes	diabetes	NOUN
ijpds-3217	143	27	mellitus	mellitus	NOUN
ijpds-3217	143	28	..	..	PUNCT
ijpds-3217	143	29	jksus	jksus	PROPN
ijpds-3217	143	30	.	.	PUNCT
ijpds-3217	144	1	2020	2020	NUM
ijpds-3217	144	2	;	;	PUNCT
ijpds-3217	144	3	32	32	NUM
ijpds-3217	144	4	:	:	SYM
ijpds-3217	144	5	2069	2069	NUM
ijpds-3217	144	6	2073	2073	NUM
ijpds-3217	144	7	.	.	PUNCT
ijpds-3217	145	1	4	4	X
ijpds-3217	145	2	.	.	X
ijpds-3217	145	3	ramachandran	ramachandran	PROPN
ijpds-3217	145	4	,	,	PUNCT
ijpds-3217	145	5	a	a	PRON
ijpds-3217	145	6	,	,	PUNCT
ijpds-3217	145	7	ramachandran	ramachandran	PROPN
ijpds-3217	145	8	,	,	PUNCT
ijpds-3217	145	9	s	s	AUX
ijpds-3217	145	10	,	,	PUNCT
ijpds-3217	145	11	snehalatha	snehalatha	VERB
ijpds-3217	145	12	,	,	PUNCT
ijpds-3217	145	13	c	c	X
ijpds-3217	145	14	,	,	PUNCT
ijpds-3217	145	15	et	et	PROPN
ijpds-3217	145	16	al	al	PROPN
ijpds-3217	145	17	.	.	PUNCT
ijpds-3217	146	1	increasing	increase	VERB
ijpds-3217	146	2	expenditure	expenditure	NOUN
ijpds-3217	146	3	on	on	ADP
ijpds-3217	146	4	health	health	NOUN
ijpds-3217	146	5	care	care	NOUN
ijpds-3217	146	6	incurred	incur	VERB
ijpds-3217	146	7	by	by	ADP
ijpds-3217	146	8	diabetic	diabetic	ADJ
ijpds-3217	146	9	subjects	subject	NOUN
ijpds-3217	146	10	in	in	ADP
ijpds-3217	146	11	a	a	DET
ijpds-3217	146	12	developing	develop	VERB
ijpds-3217	146	13	country	country	NOUN
ijpds-3217	146	14	:	:	PUNCT
ijpds-3217	146	15	a	a	DET
ijpds-3217	146	16	study	study	NOUN
ijpds-3217	146	17	from	from	ADP
ijpds-3217	146	18	india	india	PROPN
ijpds-3217	146	19	.	.	PUNCT
ijpds-3217	147	1	diabetes	diabetes	NOUN
ijpds-3217	147	2	care	care	NOUN
ijpds-3217	147	3	.	.	PUNCT
ijpds-3217	148	1	2007	2007	NUM
ijpds-3217	148	2	;	;	PUNCT
ijpds-3217	148	3	30	30	NUM
ijpds-3217	148	4	:	:	PUNCT
ijpds-3217	148	5	252	252	NUM
ijpds-3217	148	6	256	256	NUM
ijpds-3217	148	7	.	.	PUNCT
ijpds-3217	149	1	5	5	NUM
ijpds-3217	149	2	.	.	X
ijpds-3217	150	1	lin	lin	PROPN
ijpds-3217	150	2	j.j	j.j	PROPN
ijpds-3217	150	3	,	,	PUNCT
ijpds-3217	150	4	chang	chang	PROPN
ijpds-3217	150	5	h.c	h.c	PROPN
ijpds-3217	150	6	,	,	PUNCT
ijpds-3217	150	7	ku	ku	PROPN
ijpds-3217	150	8	c.t	c.t	PROPN
ijpds-3217	150	9	,	,	PUNCT
ijpds-3217	150	10	et	et	PROPN
ijpds-3217	150	11	al	al	PROPN
ijpds-3217	150	12	.	.	PROPN
ijpds-3217	151	1	hydrochlorothiazide	hydrochlorothiazide	PROPN
ijpds-3217	151	2	hypertension	hypertension	NOUN
ijpds-3217	151	3	treatment	treatment	NOUN
ijpds-3217	151	4	induced	induce	VERB
ijpds-3217	151	5	metabolic	metabolic	NOUN
ijpds-3217	151	6	effects	effect	NOUN
ijpds-3217	151	7	in	in	ADP
ijpds-3217	151	8	type	type	NOUN
ijpds-3217	151	9	2	2	NUM
ijpds-3217	151	10	diabetes	diabetes	NOUN
ijpds-3217	151	11	:	:	PUNCT
ijpds-3217	151	12	a	a	DET
ijpds-3217	151	13	meta	meta	ADJ
ijpds-3217	151	14	-	-	PUNCT
ijpds-3217	151	15	analysis	analysis	NOUN
ijpds-3217	151	16	of	of	ADP
ijpds-3217	151	17	parallel	parallel	ADJ
ijpds-3217	151	18	design	design	NOUN
ijpds-3217	151	19	rcts	rct	NOUN
ijpds-3217	151	20	.	.	PUNCT
ijpds-3217	152	1	eur	eur	PROPN
ijpds-3217	152	2	rev	rev	PROPN
ijpds-3217	152	3	med	med	PROPN
ijpds-3217	152	4	pharmacol	pharmacol	PROPN
ijpds-3217	152	5	sci	sci	PROPN
ijpds-3217	152	6	.	.	PROPN
ijpds-3217	152	7	,	,	PUNCT
ijpds-3217	152	8	2016	2016	NUM
ijpds-3217	152	9	;	;	PUNCT
ijpds-3217	152	10	20	20	NUM
ijpds-3217	152	11	:	:	SYM
ijpds-3217	152	12	2926	2926	NUM
ijpds-3217	152	13	2934	2934	NUM
ijpds-3217	152	14	.	.	PUNCT
ijpds-3217	153	1	6	6	NUM
ijpds-3217	153	2	.	.	X
ijpds-3217	153	3	scheen	scheen	PROPN
ijpds-3217	153	4	a.j	a.j	PROPN
ijpds-3217	153	5	.	.	PROPN
ijpds-3217	153	6	type	type	NOUN
ijpds-3217	153	7	2	2	NUM
ijpds-3217	153	8	diabetes	diabetes	NOUN
ijpds-3217	153	9	and	and	CCONJ
ijpds-3217	153	10	thiazide	thiazide	ADP
ijpds-3217	153	11	diuretics	diuretic	NOUN
ijpds-3217	153	12	.	.	PUNCT
ijpds-3217	154	1	curr	curr	PROPN
ijpds-3217	154	2	.	.	PUNCT
ijpds-3217	155	1	diab	diab	PROPN
ijpds-3217	155	2	.	.	PUNCT
ijpds-3217	156	1	rep	rep	PROPN
ijpds-3217	156	2	.	.	PROPN
ijpds-3217	156	3	2018	2018	NUM
ijpds-3217	156	4	;	;	PUNCT
ijpds-3217	156	5	18	18	NUM
ijpds-3217	156	6	:	:	SYM
ijpds-3217	156	7	1	1	NUM
ijpds-3217	156	8	-	-	SYM
ijpds-3217	156	9	13	13	NUM
ijpds-3217	156	10	.	.	PUNCT
ijpds-3217	157	1	7	7	X
ijpds-3217	157	2	.	.	X
ijpds-3217	157	3	american	american	ADJ
ijpds-3217	157	4	diabetes	diabetes	PROPN
ijpds-3217	157	5	association	association	PROPN
ijpds-3217	157	6	.	.	PUNCT
ijpds-3217	158	1	standards	standard	NOUN
ijpds-3217	158	2	of	of	ADP
ijpds-3217	158	3	medical	medical	ADJ
ijpds-3217	158	4	care	care	NOUN
ijpds-3217	158	5	in	in	ADP
ijpds-3217	158	6	diabetes	diabetes	NOUN
ijpds-3217	158	7	.	.	PUNCT
ijpds-3217	159	1	diabetes	diabetes	NOUN
ijpds-3217	159	2	care	care	NOUN
ijpds-3217	159	3	.	.	PUNCT
ijpds-3217	160	1	2004	2004	NUM
ijpds-3217	160	2	;	;	PUNCT
ijpds-3217	160	3	27	27	NUM
ijpds-3217	160	4	:	:	PUNCT
ijpds-3217	160	5	s15	s15	PROPN
ijpds-3217	160	6	s35	s35	PROPN
ijpds-3217	160	7	.	.	PROPN
ijpds-3217	160	8	8	8	NUM
ijpds-3217	160	9	.	.	PUNCT
ijpds-3217	161	1	krum	krum	PROPN
ijpds-3217	161	2	h	h	PROPN
ijpds-3217	161	3	,	,	PUNCT
ijpds-3217	161	4	skiba	skiba	PROPN
ijpds-3217	161	5	,	,	PUNCT
ijpds-3217	161	6	m	m	PROPN
ijpds-3217	161	7	,	,	PUNCT
ijpds-3217	161	8	gilbert	gilbert	PROPN
ijpds-3217	161	9	r.e	r.e	PROPN
ijpds-3217	161	10	.	.	PROPN
ijpds-3217	161	11	comparative	comparative	ADJ
ijpds-3217	161	12	metabolic	metabolic	NOUN
ijpds-3217	161	13	effects	effect	NOUN
ijpds-3217	161	14	of	of	ADP
ijpds-3217	161	15	hydrochlorothiazide	hydrochlorothiazide	NOUN
ijpds-3217	161	16	and	and	CCONJ
ijpds-3217	161	17	indapamide	indapamide	ADV
ijpds-3217	161	18	in	in	ADP
ijpds-3217	161	19	hypertensive	hypertensive	ADJ
ijpds-3217	161	20	diabetic	diabetic	ADJ
ijpds-3217	161	21	patients	patient	NOUN
ijpds-3217	161	22	.	.	PUNCT
ijpds-3217	162	1	diabetic	diabetic	ADJ
ijpds-3217	162	2	medicine	medicine	NOUN
ijpds-3217	162	3	.	.	PUNCT
ijpds-3217	163	1	2003	2003	NUM
ijpds-3217	163	2	;	;	PUNCT
ijpds-3217	163	3	20	20	NUM
ijpds-3217	163	4	:	:	SYM
ijpds-3217	163	5	708	708	NUM
ijpds-3217	163	6	712	712	NUM
ijpds-3217	163	7	.	.	PUNCT
ijpds-3217	164	1	9	9	NUM
ijpds-3217	164	2	.	.	X
ijpds-3217	164	3	mazzuchello	mazzuchello	PROPN
ijpds-3217	164	4	f.r	f.r	PROPN
ijpds-3217	164	5	,	,	PUNCT
ijpds-3217	164	6	tuon	tuon	NOUN
ijpds-3217	164	7	l	l	NOUN
ijpds-3217	164	8	,	,	PUNCT
ijpds-3217	164	9	simões	simões	ADJ
ijpds-3217	164	10	p.w	p.w	PROPN
ijpds-3217	164	11	,	,	PUNCT
ijpds-3217	164	12	et	et	PROPN
ijpds-3217	164	13	al	al	PROPN
ijpds-3217	164	14	.	.	PROPN
ijpds-3217	164	15	knowledge	knowledge	PROPN
ijpds-3217	164	16	,	,	PUNCT
ijpds-3217	164	17	attitudes	attitude	NOUN
ijpds-3217	164	18	and	and	CCONJ
ijpds-3217	164	19	adherence	adherence	NOUN
ijpds-3217	164	20	to	to	ADP
ijpds-3217	164	21	treatment	treatment	NOUN
ijpds-3217	164	22	in	in	ADP
ijpds-3217	164	23	individuals	individual	NOUN
ijpds-3217	164	24	with	with	ADP
ijpds-3217	164	25	hypertension	hypertension	NOUN
ijpds-3217	164	26	and	and	CCONJ
ijpds-3217	164	27	diabetes	diabetes	NOUN
ijpds-3217	164	28	mellitus	mellitus	PROPN
ijpds-3217	164	29	.	.	PUNCT
ijpds-3217	165	1	mundo	mundo	PROPN
ijpds-3217	165	2	saúde	saúde	PROPN
ijpds-3217	165	3	.	.	PUNCT
ijpds-3217	166	1	2016	2016	NUM
ijpds-3217	166	2	;	;	PUNCT
ijpds-3217	166	3	40	40	NUM
ijpds-3217	166	4	:	:	SYM
ijpds-3217	166	5	418	418	NUM
ijpds-3217	166	6	432	432	NUM
ijpds-3217	166	7	.	.	PUNCT
ijpds-3217	167	1	10	10	NUM
ijpds-3217	167	2	.	.	X
ijpds-3217	167	3	rosendorff	rosendorff	NOUN
ijpds-3217	167	4	,	,	PUNCT
ijpds-3217	167	5	c.	c.	PROPN
ijpds-3217	167	6	why	why	SCONJ
ijpds-3217	167	7	are	be	AUX
ijpds-3217	167	8	we	we	PRON
ijpds-3217	167	9	still	still	ADV
ijpds-3217	167	10	using	use	VERB
ijpds-3217	167	11	hydrochlorothiazide	hydrochlorothiazide	NOUN
ijpds-3217	167	12	?	?	PUNCT
ijpds-3217	168	1	j.	j.	PROPN
ijpds-3217	168	2	clin	clin	PROPN
ijpds-3217	168	3	.	.	PUNCT
ijpds-3217	169	1	hypertens	hypertens	PROPN
ijpds-3217	169	2	.	.	PUNCT
ijpds-3217	170	1	2011	2011	NUM
ijpds-3217	170	2	;	;	PUNCT
ijpds-3217	170	3	13	13	NUM
ijpds-3217	170	4	:	:	SYM
ijpds-3217	170	5	867	867	NUM
ijpds-3217	170	6	869	869	NUM
ijpds-3217	170	7	.	.	PUNCT
ijpds-3217	171	1	11	11	NUM
ijpds-3217	171	2	.	.	PUNCT
ijpds-3217	172	1	ribeiro	ribeiro	PROPN
ijpds-3217	172	2	,	,	PUNCT
ijpds-3217	172	3	j.m	j.m	PROPN
ijpds-3217	172	4	.	.	PROPN
ijpds-3217	172	5	hypertension	hypertension	NOUN
ijpds-3217	172	6	guidelines	guideline	NOUN
ijpds-3217	172	7	:	:	PUNCT
ijpds-3217	172	8	a	a	DET
ijpds-3217	172	9	view	view	NOUN
ijpds-3217	172	10	from	from	ADP
ijpds-3217	172	11	latin	latin	PROPN
ijpds-3217	172	12	america	america	PROPN
ijpds-3217	172	13	.	.	PUNCT
ijpds-3217	173	1	j.	j.	PROPN
ijpds-3217	173	2	clin	clin	PROPN
ijpds-3217	173	3	.	.	PUNCT
ijpds-3217	174	1	hypertens	hypertens	PROPN
ijpds-3217	174	2	.	.	PUNCT
ijpds-3217	175	1	2014	2014	NUM
ijpds-3217	175	2	;	;	PUNCT
ijpds-3217	175	3	16	16	NUM
ijpds-3217	175	4	:	:	SYM
ijpds-3217	175	5	261	261	NUM
ijpds-3217	175	6	262	262	NUM
ijpds-3217	175	7	.	.	PUNCT
ijpds-3217	176	1	12	12	NUM
ijpds-3217	176	2	.	.	PUNCT
ijpds-3217	177	1	hall	hall	PROPN
ijpds-3217	177	2	j.j	j.j	PROPN
ijpds-3217	177	3	,	,	PUNCT
ijpds-3217	177	4	eurich	eurich	NOUN
ijpds-3217	177	5	d.t	d.t	PROPN
ijpds-3217	177	6	,	,	PUNCT
ijpds-3217	177	7	nagy	nagy	PROPN
ijpds-3217	177	8	d	d	PROPN
ijpds-3217	177	9	,	,	PUNCT
ijpds-3217	177	10	et	et	PROPN
ijpds-3217	177	11	al	al	PROPN
ijpds-3217	177	12	.	.	PROPN
ijpds-3217	178	1	thiazide	thiazide	PROPN
ijpds-3217	178	2	diuretic	diuretic	ADJ
ijpds-3217	178	3	–	–	PUNCT
ijpds-3217	178	4	induced	induce	VERB
ijpds-3217	178	5	change	change	NOUN
ijpds-3217	178	6	in	in	ADP
ijpds-3217	178	7	fasting	fast	VERB
ijpds-3217	178	8	plasma	plasma	NOUN
ijpds-3217	178	9	glucose	glucose	NOUN
ijpds-3217	178	10	:	:	PUNCT
ijpds-3217	178	11	a	a	DET
ijpds-3217	178	12	meta	meta	ADJ
ijpds-3217	178	13	-	-	PUNCT
ijpds-3217	178	14	analysis	analysis	NOUN
ijpds-3217	178	15	of	of	ADP
ijpds-3217	178	16	randomized	randomized	ADJ
ijpds-3217	178	17	clinical	clinical	ADJ
ijpds-3217	178	18	trials	trial	NOUN
ijpds-3217	178	19	.	.	PUNCT
ijpds-3217	179	1	j	j	PROPN
ijpds-3217	179	2	gen	gen	PROPN
ijpds-3217	179	3	intern	intern	NOUN
ijpds-3217	179	4	med	me	VERB
ijpds-3217	179	5	.	.	PUNCT
ijpds-3217	180	1	2020	2020	NUM
ijpds-3217	180	2	;	;	PUNCT
ijpds-3217	181	1	35	35	NUM
ijpds-3217	181	2	:	:	SYM
ijpds-3217	181	3	1849	1849	NUM
ijpds-3217	181	4	1860	1860	NUM
ijpds-3217	181	5	.	.	PUNCT
ijpds-3217	182	1	13	13	NUM
ijpds-3217	182	2	.	.	PUNCT
ijpds-3217	182	3	carter	carter	PROPN
ijpds-3217	182	4	b.l	b.l	PROPN
ijpds-3217	182	5	,	,	PUNCT
ijpds-3217	182	6	basile	basile	PROPN
ijpds-3217	182	7	j.	j.	PROPN
ijpds-3217	182	8	development	development	PROPN
ijpds-3217	182	9	of	of	ADP
ijpds-3217	182	10	diabetes	diabetes	NOUN
ijpds-3217	182	11	with	with	ADP
ijpds-3217	182	12	thiazide	thiazide	ADJ
ijpds-3217	182	13	diuretics	diuretic	NOUN
ijpds-3217	182	14	:	:	PUNCT
ijpds-3217	182	15	the	the	DET
ijpds-3217	182	16	potassium	potassium	NOUN
ijpds-3217	182	17	issue	issue	NOUN
ijpds-3217	182	18	.	.	PUNCT
ijpds-3217	183	1	j	j	PROPN
ijpds-3217	183	2	clin	clin	PROPN
ijpds-3217	183	3	hypert	hypert	PROPN
ijpds-3217	183	4	.	.	PROPN
ijpds-3217	184	1	2005	2005	NUM
ijpds-3217	184	2	;	;	PUNCT
ijpds-3217	184	3	7	7	NUM
ijpds-3217	184	4	:	:	SYM
ijpds-3217	184	5	638640	638640	NUM
ijpds-3217	184	6	.	.	PUNCT
ijpds-3217	185	1	14	14	NUM
ijpds-3217	185	2	.	.	PUNCT
ijpds-3217	186	1	burniera	burniera	PROPN
ijpds-3217	186	2	m	m	PROPN
ijpds-3217	186	3	,	,	PUNCT
ijpds-3217	186	4	bakrisc	bakrisc	VERB
ijpds-3217	186	5	g	g	PROPN
ijpds-3217	186	6	,	,	PUNCT
ijpds-3217	186	7	williams	williams	PROPN
ijpds-3217	186	8	b.	b.	PROPN
ijpds-3217	186	9	redefining	redefine	VERB
ijpds-3217	186	10	diuretics	diuretic	NOUN
ijpds-3217	186	11	use	use	NOUN
ijpds-3217	186	12	in	in	ADP
ijpds-3217	186	13	hypertension	hypertension	NOUN
ijpds-3217	186	14	:	:	PUNCT
ijpds-3217	186	15	why	why	SCONJ
ijpds-3217	186	16	select	select	VERB
ijpds-3217	186	17	a	a	DET
ijpds-3217	186	18	thiazide	thiazide	ADV
ijpds-3217	186	19	-	-	PUNCT
ijpds-3217	186	20	like	like	ADJ
ijpds-3217	186	21	diuretic	diuretic	NOUN
ijpds-3217	186	22	?	?	PUNCT
ijpds-3217	187	1	j	j	PROPN
ijpds-3217	187	2	hypert	hypert	PROPN
ijpds-3217	187	3	.	.	PROPN
ijpds-3217	188	1	2019	2019	NUM
ijpds-3217	188	2	;	;	PUNCT
ijpds-3217	188	3	37	37	NUM
ijpds-3217	188	4	:	:	SYM
ijpds-3217	188	5	1574	1574	NUM
ijpds-3217	188	6	1586	1586	NUM
ijpds-3217	188	7	.	.	PUNCT
ijpds-3217	189	1	15	15	NUM
ijpds-3217	189	2	.	.	X
ijpds-3217	189	3	berova	berova	PROPN
ijpds-3217	189	4	,	,	PUNCT
ijpds-3217	189	5	n	n	CCONJ
ijpds-3217	189	6	,	,	PUNCT
ijpds-3217	189	7	nakanishi	nakanishi	PROPN
ijpds-3217	189	8	,	,	PUNCT
ijpds-3217	189	9	k	k	PROPN
ijpds-3217	189	10	,	,	PUNCT
ijpds-3217	189	11	woody	woody	NOUN
ijpds-3217	189	12	.	.	PUNCT
ijpds-3217	190	1	r.w	r.w	PROPN
ijpds-3217	190	2	.	.	PROPN
ijpds-3217	190	3	circular	circular	ADJ
ijpds-3217	190	4	dichroism	dichroism	NOUN
ijpds-3217	190	5	:	:	PUNCT
ijpds-3217	190	6	principles	principle	NOUN
ijpds-3217	190	7	and	and	CCONJ
ijpds-3217	190	8	applications	application	NOUN
ijpds-3217	190	9	,	,	PUNCT
ijpds-3217	190	10	2nd	2nd	ADJ
ijpds-3217	190	11	ed	ed	NOUN
ijpds-3217	190	12	.	.	PROPN
ijpds-3217	190	13	,	,	PUNCT
ijpds-3217	190	14	wiley	wiley	PROPN
ijpds-3217	190	15	vch	vch	PROPN
ijpds-3217	190	16	:	:	PUNCT
ijpds-3217	190	17	new	new	PROPN
ijpds-3217	190	18	york	york	PROPN
ijpds-3217	190	19	,	,	PUNCT
ijpds-3217	190	20	2000	2000	NUM
ijpds-3217	190	21	.	.	PUNCT
ijpds-3217	191	1	16	16	NUM
ijpds-3217	191	2	.	.	PUNCT
ijpds-3217	192	1	xie	xie	PROPN
ijpds-3217	192	2	x.y	x.y	PROPN
ijpds-3217	192	3	,	,	PUNCT
ijpds-3217	192	4	lu	lu	PROPN
ijpds-3217	192	5	w.j	w.j	PROPN
ijpds-3217	192	6	,	,	PUNCT
ijpds-3217	192	7	chen	chen	PROPN
ijpds-3217	192	8	x.g	x.g	PROPN
ijpds-3217	192	9	.	.	PROPN
ijpds-3217	192	10	binding	bind	VERB
ijpds-3217	192	11	of	of	ADP
ijpds-3217	192	12	the	the	DET
ijpds-3217	192	13	endocrine	endocrine	ADJ
ijpds-3217	192	14	disruptors	disruptor	NOUN
ijpds-3217	192	15	4	4	NUM
ijpds-3217	192	16	–	–	PUNCT
ijpds-3217	192	17	tert	tert	NOUN
ijpds-3217	192	18	octylphenol	octylphenol	NOUN
ijpds-3217	192	19	and	and	CCONJ
ijpds-3217	192	20	4	4	NUM
ijpds-3217	192	21	nonylphenol	nonylphenol	NOUN
ijpds-3217	192	22	to	to	ADP
ijpds-3217	192	23	human	human	ADJ
ijpds-3217	192	24	serum	serum	NOUN
ijpds-3217	192	25	albumin	albumin	PROPN
ijpds-3217	192	26	.	.	PUNCT
ijpds-3217	193	1	j	j	PROPN
ijpds-3217	193	2	hazard	hazard	PROPN
ijpds-3217	193	3	mater	mater	NOUN
ijpds-3217	193	4	.	.	PUNCT
ijpds-3217	194	1	2013	2013	NUM
ijpds-3217	194	2	;	;	PUNCT
ijpds-3217	194	3	15	15	NUM
ijpds-3217	194	4	:	:	SYM
ijpds-3217	194	5	347	347	NUM
ijpds-3217	194	6	354	354	NUM
ijpds-3217	194	7	.	.	PUNCT
ijpds-3217	194	8	17	17	NUM
ijpds-3217	194	9	.	.	PUNCT
ijpds-3217	195	1	sekar	sekar	PROPN
ijpds-3217	195	2	g	g	PROPN
ijpds-3217	195	3	,	,	PUNCT
ijpds-3217	195	4	haldar	haldar	NOUN
ijpds-3217	195	5	m	m	PROPN
ijpds-3217	195	6	,	,	PUNCT
ijpds-3217	195	7	kumar	kumar	PROPN
ijpds-3217	195	8	d.t	d.t	PROPN
ijpds-3217	195	9	,	,	PUNCT
ijpds-3217	195	10	et	et	PROPN
ijpds-3217	195	11	al	al	PROPN
ijpds-3217	195	12	.	.	PUNCT
ijpds-3217	196	1	exploring	explore	VERB
ijpds-3217	196	2	the	the	DET
ijpds-3217	196	3	interaction	interaction	NOUN
ijpds-3217	196	4	between	between	ADP
ijpds-3217	196	5	iron	iron	NOUN
ijpds-3217	196	6	oxide	oxide	NOUN
ijpds-3217	196	7	nanoparticles	nanoparticle	NOUN
ijpds-3217	196	8	(	(	PUNCT
ijpds-3217	196	9	ionps	ionps	NOUN
ijpds-3217	196	10	)	)	PUNCT
ijpds-3217	196	11	and	and	CCONJ
ijpds-3217	196	12	human	human	ADJ
ijpds-3217	196	13	serum	serum	NOUN
ijpds-3217	196	14	albumin	albumin	PROPN
ijpds-3217	196	15	(	(	PUNCT
ijpds-3217	196	16	hsa	hsa	PROPN
ijpds-3217	196	17	):	):	PUNCT
ijpds-3217	196	18	spectroscopic	spectroscopic	ADJ
ijpds-3217	196	19	and	and	CCONJ
ijpds-3217	196	20	docking	dock	VERB
ijpds-3217	196	21	studies	study	NOUN
ijpds-3217	196	22	.	.	PUNCT
ijpds-3217	197	1	j	j	PROPN
ijpds-3217	197	2	mol	mol	ADP
ijpds-3217	197	3	liq	liq	PROPN
ijpds-3217	197	4	.	.	PUNCT
ijpds-3217	197	5	2017	2017	NUM
ijpds-3217	197	6	;	;	PUNCT
ijpds-3217	197	7	241	241	NUM
ijpds-3217	197	8	:	:	PUNCT
ijpds-3217	197	9	793	793	NUM
ijpds-3217	197	10	800	800	NUM
ijpds-3217	197	11	.	.	PUNCT
ijpds-3217	197	12	18	18	NUM
ijpds-3217	197	13	.	.	PUNCT
ijpds-3217	197	14	mu	mu	PROPN
ijpds-3217	197	15	h	h	PROPN
ijpds-3217	197	16	,	,	PUNCT
ijpds-3217	197	17	chen	chen	PROPN
ijpds-3217	197	18	s	s	PROPN
ijpds-3217	197	19	,	,	PUNCT
ijpds-3217	197	20	liu	liu	PROPN
ijpds-3217	197	21	,	,	PUNCT
ijpds-3217	197	22	f	f	PROPN
ijpds-3217	197	23	,	,	PUNCT
ijpds-3217	197	24	et	et	PROPN
ijpds-3217	197	25	al	al	PROPN
ijpds-3217	197	26	.	.	PUNCT
ijpds-3217	197	27	stereoselective	stereoselective	ADJ
ijpds-3217	197	28	interactions	interaction	NOUN
ijpds-3217	197	29	of	of	ADP
ijpds-3217	197	30	lactic	lactic	ADJ
ijpds-3217	197	31	acid	acid	NOUN
ijpds-3217	197	32	enantiomers	enantiomer	NOUN
ijpds-3217	197	33	with	with	ADP
ijpds-3217	197	34	hsaspectroscopy	hsaspectroscopy	NOUN
ijpds-3217	197	35	and	and	CCONJ
ijpds-3217	197	36	docking	dock	VERB
ijpds-3217	197	37	application	application	NOUN
ijpds-3217	197	38	.	.	PUNCT
ijpds-3217	198	1	food	food	NOUN
ijpds-3217	198	2	chem	chem	NOUN
ijpds-3217	198	3	.	.	PUNCT
ijpds-3217	199	1	2019	2019	NUM
ijpds-3217	199	2	;	;	PUNCT
ijpds-3217	200	1	270	270	NUM
ijpds-3217	200	2	:	:	SYM
ijpds-3217	200	3	429	429	NUM
ijpds-3217	200	4	435	435	NUM
ijpds-3217	200	5	.	.	PUNCT
ijpds-3217	201	1	19	19	NUM
ijpds-3217	201	2	.	.	X
ijpds-3217	201	3	jasco-815	jasco-815	PROPN
ijpds-3217	201	4	https://www.fresnostate.edu/csm/rimi/documents/equipme	https://www.fresnostate.edu/csm/rimi/documents/equipme	PROPN
ijpds-3217	201	5	nt	nt	PROPN
ijpds-3217	201	6	/	/	SYM
ijpds-3217	201	7	jasco%20815_s.pdf	jasco%20815_s.pdf	PROPN
ijpds-3217	201	8	,	,	PUNCT
ijpds-3217	201	9	(	(	PUNCT
ijpds-3217	201	10	accessed	access	VERB
ijpds-3217	201	11	ago	ago	ADV
ijpds-3217	201	12	30	30	NUM
ijpds-3217	201	13	,	,	PUNCT
ijpds-3217	201	14	2020	2020	NUM
ijpds-3217	201	15	)	)	PUNCT
ijpds-3217	201	16	.	.	PUNCT
ijpds-3217	202	1	20	20	NUM
ijpds-3217	202	2	.	.	X
ijpds-3217	202	3	silva	silva	PROPN
ijpds-3217	202	4	d	d	PROPN
ijpds-3217	202	5	,	,	PUNCT
ijpds-3217	202	6	cortez	cortez	PROPN
ijpds-3217	202	7	c.m	c.m	PROPN
ijpds-3217	202	8	,	,	PUNCT
ijpds-3217	202	9	nogueira	nogueira	PROPN
ijpds-3217	202	10	n.p	n.p	PROPN
ijpds-3217	202	11	,	,	PUNCT
ijpds-3217	202	12	et	et	PROPN
ijpds-3217	202	13	al	al	PROPN
ijpds-3217	202	14	.	.	PUNCT
ijpds-3217	203	1	purification	purification	NOUN
ijpds-3217	203	2	and	and	CCONJ
ijpds-3217	203	3	physic	physic	ADJ
ijpds-3217	203	4	chemical	chemical	NOUN
ijpds-3217	203	5	study	study	NOUN
ijpds-3217	203	6	of	of	ADP
ijpds-3217	203	7	serum	serum	NOUN
ijpds-3217	203	8	albumins	albumin	NOUN
ijpds-3217	203	9	of	of	ADP
ijpds-3217	203	10	two	two	NUM
ijpds-3217	203	11	neotropical	neotropical	ADJ
ijpds-3217	203	12	fish	fish	NOUN
ijpds-3217	203	13	species	specie	NOUN
ijpds-3217	203	14	from	from	ADP
ijpds-3217	203	15	the	the	DET
ijpds-3217	203	16	são	são	PROPN
ijpds-3217	203	17	francisco	francisco	PROPN
ijpds-3217	203	18	river	river	PROPN
ijpds-3217	203	19	bassin	bassin	PROPN
ijpds-3217	203	20	,	,	PUNCT
ijpds-3217	203	21	brazil	brazil	PROPN
ijpds-3217	203	22	.	.	PUNCT
ijpds-3217	204	1	biota	biota	NOUN
ijpds-3217	204	2	neotropica	neotropica	PROPN
ijpds-3217	204	3	.	.	PUNCT
ijpds-3217	205	1	2015	2015	NUM
ijpds-3217	205	2	;	;	PUNCT
ijpds-3217	205	3	15(3	15(3	NUM
ijpds-3217	205	4	):	):	PUNCT
ijpds-3217	205	5	e20140179	e20140179	NOUN
ijpds-3217	205	6	.	.	PUNCT
ijpds-3217	206	1	21	21	NUM
ijpds-3217	206	2	.	.	PUNCT
ijpds-3217	207	1	zaidi	zaidi	PROPN
ijpds-3217	207	2	n	n	CCONJ
ijpds-3217	207	3	,	,	PUNCT
ijpds-3217	207	4	ajmal	ajmal	PROPN
ijpds-3217	207	5	m.r	m.r	PROPN
ijpds-3217	207	6	,	,	PUNCT
ijpds-3217	207	7	rabbani	rabbani	PROPN
ijpds-3217	207	8	g	g	PROPN
ijpds-3217	207	9	,	,	PUNCT
ijpds-3217	207	10	et	et	PROPN
ijpds-3217	207	11	al	al	PROPN
ijpds-3217	207	12	.	.	PUNCT
ijpds-3217	208	1	a	a	DET
ijpds-3217	208	2	comprehensive	comprehensive	ADJ
ijpds-3217	208	3	insight	insight	NOUN
ijpds-3217	208	4	into	into	ADP
ijpds-3217	208	5	binding	bind	VERB
ijpds-3217	208	6	of	of	ADP
ijpds-3217	208	7	hippuric	hippuric	ADJ
ijpds-3217	208	8	acid	acid	NOUN
ijpds-3217	208	9	to	to	ADP
ijpds-3217	208	10	human	human	ADJ
ijpds-3217	208	11	serum	serum	NOUN
ijpds-3217	208	12	albumin	albumin	NOUN
ijpds-3217	208	13	:	:	PUNCT
ijpds-3217	208	14	a	a	DET
ijpds-3217	208	15	study	study	NOUN
ijpds-3217	208	16	to	to	PART
ijpds-3217	208	17	uncover	uncover	VERB
ijpds-3217	208	18	its	its	PRON
ijpds-3217	208	19	impaired	impaired	ADJ
ijpds-3217	208	20	elimination	elimination	NOUN
ijpds-3217	208	21	through	through	ADP
ijpds-3217	208	22	hemodialysis	hemodialysis	NOUN
ijpds-3217	208	23	.	.	PUNCT
ijpds-3217	209	1	plos	plos	PROPN
ijpds-3217	209	2	one	one	NUM
ijpds-3217	209	3	.	.	PUNCT
ijpds-3217	209	4	2013	2013	NUM
ijpds-3217	209	5	;	;	PUNCT
ijpds-3217	209	6	8	8	NUM
ijpds-3217	209	7	:	:	PUNCT
ijpds-3217	209	8	e71422	e71422	NUM
ijpds-3217	209	9	.	.	PUNCT
ijpds-3217	210	1	22	22	NUM
ijpds-3217	210	2	.	.	PUNCT
ijpds-3217	211	1	wardell	wardell	PROPN
ijpds-3217	211	2	m	m	PROPN
ijpds-3217	211	3	,	,	PUNCT
ijpds-3217	211	4	wang	wang	PROPN
ijpds-3217	211	5	z	z	PROPN
ijpds-3217	211	6	,	,	PUNCT
ijpds-3217	211	7	ho	ho	PROPN
ijpds-3217	211	8	j.x	j.x	PROPN
ijpds-3217	211	9	,	,	PUNCT
ijpds-3217	211	10	et	et	PROPN
ijpds-3217	211	11	al	al	PROPN
ijpds-3217	211	12	.	.	PUNCT
ijpds-3217	212	1	the	the	DET
ijpds-3217	212	2	atomic	atomic	ADJ
ijpds-3217	212	3	structure	structure	NOUN
ijpds-3217	212	4	of	of	ADP
ijpds-3217	212	5	human	human	ADJ
ijpds-3217	212	6	methemalbumin	methemalbumin	NOUN
ijpds-3217	212	7	at	at	ADP
ijpds-3217	212	8	1.9	1.9	NUM
ijpds-3217	212	9	a.	a.	NOUN
ijpds-3217	212	10	biochem	biochem	PROPN
ijpds-3217	212	11	biophys	biophys	PROPN
ijpds-3217	212	12	res	res	PROPN
ijpds-3217	212	13	commun	commun	PROPN
ijpds-3217	212	14	.	.	PUNCT
ijpds-3217	212	15	2002	2002	NUM
ijpds-3217	212	16	;	;	PUNCT
ijpds-3217	212	17	291	291	NUM
ijpds-3217	212	18	:	:	PUNCT
ijpds-3217	212	19	913	913	NUM
ijpds-3217	212	20	918	918	NUM
ijpds-3217	212	21	.	.	PUNCT
ijpds-3217	212	22	23	23	NUM
ijpds-3217	212	23	.	.	PUNCT
ijpds-3217	213	1	chaves	chaves	PROPN
ijpds-3217	213	2	o.a	o.a	PROPN
ijpds-3217	213	3	,	,	PUNCT
ijpds-3217	213	4	santos	santos	PROPN
ijpds-3217	213	5	m.r.l	m.r.l	NOUN
ijpds-3217	213	6	,	,	PUNCT
ijpds-3217	213	7	oliveira	oliveira	PROPN
ijpds-3217	213	8	m.c.c	m.c.c	PROPN
ijpds-3217	213	9	,	,	PUNCT
ijpds-3217	213	10	et	et	PROPN
ijpds-3217	213	11	al	al	PROPN
ijpds-3217	213	12	.	.	PUNCT
ijpds-3217	213	13	synthesis	synthesis	NOUN
ijpds-3217	213	14	,	,	PUNCT
ijpds-3217	213	15	tyrosinase	tyrosinase	NOUN
ijpds-3217	213	16	inhibition	inhibition	NOUN
ijpds-3217	213	17	and	and	CCONJ
ijpds-3217	213	18	transportation	transportation	NOUN
ijpds-3217	213	19	behavior	behavior	NOUN
ijpds-3217	213	20	of	of	ADP
ijpds-3217	213	21	650	650	NUM
ijpds-3217	213	22	novel	novel	NOUN
ijpds-3217	213	23	βenamino	βenamino	NOUN
ijpds-3217	213	24	thiosemicarbazide	thiosemicarbazide	NOUN
ijpds-3217	213	25	derivatives	derivative	NOUN
ijpds-3217	213	26	by	by	ADP
ijpds-3217	213	27	human	human	ADJ
ijpds-3217	213	28	serum	serum	NOUN
ijpds-3217	213	29	albumin	albumin	PROPN
ijpds-3217	213	30	.	.	PUNCT
ijpds-3217	214	1	j	j	PROPN
ijpds-3217	214	2	mol	mol	ADP
ijpds-3217	214	3	liq	liq	NOUN
ijpds-3217	214	4	.	.	PUNCT
ijpds-3217	215	1	2018	2018	NUM
ijpds-3217	215	2	;	;	PUNCT
ijpds-3217	215	3	254	254	NUM
ijpds-3217	215	4	:	:	SYM
ijpds-3217	215	5	280	280	NUM
ijpds-3217	215	6	290	290	NUM
ijpds-3217	215	7	.	.	PUNCT
ijpds-3217	216	1	24	24	NUM
ijpds-3217	216	2	.	.	X
ijpds-3217	216	3	spartan’14	spartan’14	PROPN
ijpds-3217	216	4	,	,	PUNCT
ijpds-3217	216	5	wavefunction	wavefunction	PROPN
ijpds-3217	216	6	inc	inc	PROPN
ijpds-3217	216	7	.	.	PROPN
ijpds-3217	216	8	https://www.wavefun.com/	https://www.wavefun.com/	PROPN
ijpds-3217	216	9	(	(	PUNCT
ijpds-3217	216	10	accessed	access	VERB
ijpds-3217	216	11	june	june	PROPN
ijpds-3217	216	12	16	16	NUM
ijpds-3217	216	13	,	,	PUNCT
ijpds-3217	216	14	2020	2020	NUM
ijpds-3217	216	15	)	)	PUNCT
ijpds-3217	216	16	.	.	PUNCT
ijpds-3217	217	1	25	25	NUM
ijpds-3217	217	2	.	.	PUNCT
ijpds-3217	218	1	gold	gold	NOUN
ijpds-3217	218	2	protein	protein	NOUN
ijpds-3217	218	3	ligand	ligand	NOUN
ijpds-3217	218	4	docking	docking	NOUN
ijpds-3217	218	5	software	software	NOUN
ijpds-3217	218	6	,	,	PUNCT
ijpds-3217	218	7	http://www.ccdc.cam.ac.uk/solutions/csd-discovery/	http://www.ccdc.cam.ac.uk/solutions/csd-discovery/	ADJ
ijpds-3217	218	8	components	component	NOUN
ijpds-3217	218	9	/	/	SYM
ijpds-3217	218	10	gold/	gold/	NUM
ijpds-3217	218	11	(	(	PUNCT
ijpds-3217	218	12	accessed	access	VERB
ijpds-3217	218	13	june	june	PROPN
ijpds-3217	218	14	16	16	NUM
ijpds-3217	218	15	,	,	PUNCT
ijpds-3217	218	16	2020	2020	NUM
ijpds-3217	218	17	)	)	PUNCT
ijpds-3217	218	18	.	.	PUNCT
ijpds-3217	219	1	26	26	NUM
ijpds-3217	219	2	.	.	X
ijpds-3217	220	1	morais	morais	PROPN
ijpds-3217	220	2	-	-	PROPN
ijpds-3217	220	3	coura	coura	PROPN
ijpds-3217	220	4	c.p	c.p	PROPN
ijpds-3217	220	5	,	,	PUNCT
ijpds-3217	220	6	fragoso	fragoso	NOUN
ijpds-3217	220	7	v.m.s	v.m.s	PROPN
ijpds-3217	220	8	,	,	PUNCT
ijpds-3217	220	9	valdez	valdez	PROPN
ijpds-3217	220	10	e.c.n	e.c.n	PROPN
ijpds-3217	220	11	,	,	PUNCT
ijpds-3217	220	12	et	et	PROPN
ijpds-3217	220	13	al	al	PROPN
ijpds-3217	220	14	.	.	PROPN
ijpds-3217	220	15	study	study	NOUN
ijpds-3217	220	16	on	on	ADP
ijpds-3217	220	17	the	the	DET
ijpds-3217	220	18	interaction	interaction	NOUN
ijpds-3217	220	19	of	of	ADP
ijpds-3217	220	20	three	three	NUM
ijpds-3217	220	21	classical	classical	ADJ
ijpds-3217	220	22	drugs	drug	NOUN
ijpds-3217	220	23	used	use	VERB
ijpds-3217	220	24	in	in	ADP
ijpds-3217	220	25	psychiatry	psychiatry	NOUN
ijpds-3217	220	26	in	in	ADP
ijpds-3217	220	27	albumin	albumin	NOUN
ijpds-3217	220	28	through	through	ADP
ijpds-3217	220	29	spectrofluorimetric	spectrofluorimetric	ADJ
ijpds-3217	220	30	modeling	modeling	NOUN
ijpds-3217	220	31	.	.	PUNCT
ijpds-3217	221	1	spectrochim	spectrochim	PROPN
ijpds-3217	221	2	acta	acta	PROPN
ijpds-3217	221	3	a	a	PRON
ijpds-3217	221	4	,	,	PUNCT
ijpds-3217	221	5	mol	mol	ADP
ijpds-3217	221	6	biomol	biomol	PROPN
ijpds-3217	221	7	spectrosc	spectrosc	PROPN
ijpds-3217	221	8	.	.	PUNCT
ijpds-3217	222	1	2021	2021	NUM
ijpds-3217	222	2	;	;	PUNCT
ijpds-3217	222	3	255	255	NUM
ijpds-3217	222	4	:	:	SYM
ijpds-3217	222	5	119638	119638	NUM
ijpds-3217	222	6	.	.	PUNCT
ijpds-3217	223	1	27	27	NUM
ijpds-3217	223	2	.	.	PUNCT
ijpds-3217	223	3	cortez	cortez	PROPN
ijpds-3217	223	4	c.m	c.m	PROPN
ijpds-3217	223	5	,	,	PUNCT
ijpds-3217	223	6	silva	silva	PROPN
ijpds-3217	223	7	d	d	PROPN
ijpds-3217	223	8	,	,	PUNCT
ijpds-3217	223	9	silva	silva	PROPN
ijpds-3217	223	10	c.m.c	c.m.c	PROPN
ijpds-3217	223	11	,	,	PUNCT
ijpds-3217	223	12	et	et	PROPN
ijpds-3217	223	13	al	al	PROPN
ijpds-3217	223	14	.	.	PUNCT
ijpds-3217	224	1	interactions	interaction	NOUN
ijpds-3217	224	2	of	of	ADP
ijpds-3217	224	3	aptamers	aptamer	NOUN
ijpds-3217	224	4	with	with	ADP
ijpds-3217	224	5	sera	sera	NOUN
ijpds-3217	224	6	albumins	albumin	NOUN
ijpds-3217	224	7	.	.	PUNCT
ijpds-3217	225	1	spectrochim	spectrochim	PROPN
ijpds-3217	225	2	.	.	PUNCT
ijpds-3217	226	1	acta	acta	PROPN
ijpds-3217	226	2	a	a	PRON
ijpds-3217	226	3	,	,	PUNCT
ijpds-3217	226	4	mol	mol	ADP
ijpds-3217	226	5	biomol	biomol	PROPN
ijpds-3217	226	6	spectrosc	spectrosc	PROPN
ijpds-3217	226	7	.	.	PUNCT
ijpds-3217	227	1	2012	2012	NUM
ijpds-3217	227	2	;	;	PUNCT
ijpds-3217	227	3	95	95	NUM
ijpds-3217	227	4	:	:	SYM
ijpds-3217	227	5	270	270	NUM
ijpds-3217	227	6	275	275	NUM
ijpds-3217	227	7	.	.	PUNCT
ijpds-3217	228	1	28	28	NUM
ijpds-3217	228	2	.	.	PUNCT
ijpds-3217	229	1	wu	wu	PROPN
ijpds-3217	229	2	d	d	PROPN
ijpds-3217	229	3	,	,	PUNCT
ijpds-3217	229	4	wang	wang	PROPN
ijpds-3217	229	5	j	j	PROPN
ijpds-3217	229	6	,	,	PUNCT
ijpds-3217	229	7	liu	liu	PROPN
ijpds-3217	229	8	d	d	PROPN
ijpds-3217	229	9	,	,	PUNCT
ijpds-3217	229	10	et	et	PROPN
ijpds-3217	229	11	al	al	PROPN
ijpds-3217	229	12	.	.	PROPN
ijpds-3217	229	13	computational	computational	ADJ
ijpds-3217	229	14	and	and	CCONJ
ijpds-3217	229	15	spectroscopic	spectroscopic	ADJ
ijpds-3217	229	16	analysis	analysis	NOUN
ijpds-3217	229	17	of	of	ADP
ijpds-3217	229	18	interaction	interaction	NOUN
ijpds-3217	229	19	between	between	ADP
ijpds-3217	229	20	food	food	NOUN
ijpds-3217	229	21	colorant	colorant	NOUN
ijpds-3217	229	22	citrus	citrus	NOUN
ijpds-3217	229	23	red	red	PROPN
ijpds-3217	229	24	2	2	PROPN
ijpds-3217	229	25	and	and	CCONJ
ijpds-3217	229	26	human	human	ADJ
ijpds-3217	229	27	serum	serum	NOUN
ijpds-3217	229	28	albumin	albumin	PROPN
ijpds-3217	229	29	.	.	PUNCT
ijpds-3217	230	1	scientific	scientific	ADJ
ijpds-3217	230	2	reports	report	NOUN
ijpds-3217	230	3	.	.	PUNCT
ijpds-3217	231	1	2019a	2019a	NUM
ijpds-3217	231	2	;	;	PUNCT
ijpds-3217	231	3	9	9	NUM
ijpds-3217	231	4	:	:	SYM
ijpds-3217	231	5	1615	1615	NUM
ijpds-3217	231	6	.	.	PUNCT
ijpds-3217	232	1	29	29	NUM
ijpds-3217	232	2	.	.	PUNCT
ijpds-3217	233	1	delano	delano	PROPN
ijpds-3217	233	2	w.l	w.l	PROPN
ijpds-3217	233	3	.	.	PROPN
ijpds-3217	233	4	pymol	pymol	PROPN
ijpds-3217	233	5	user	user	NOUN
ijpds-3217	233	6	’s	’s	PART
ijpds-3217	233	7	guide	guide	NOUN
ijpds-3217	233	8	,	,	PUNCT
ijpds-3217	233	9	delano	delano	PROPN
ijpds-3217	233	10	scientific	scientific	PROPN
ijpds-3217	233	11	llc	llc	PROPN
ijpds-3217	233	12	.	.	PUNCT
ijpds-3217	234	1	https://pymol.org/2/	https://pymol.org/2/	PROPN
ijpds-3217	234	2	(	(	PUNCT
ijpds-3217	234	3	accessed	access	VERB
ijpds-3217	234	4	june	june	PROPN
ijpds-3217	234	5	16	16	NUM
ijpds-3217	234	6	,	,	PUNCT
ijpds-3217	234	7	2020	2020	NUM
ijpds-3217	234	8	)	)	PUNCT
ijpds-3217	234	9	.	.	PUNCT
ijpds-3217	235	1	30	30	NUM
ijpds-3217	235	2	.	.	PUNCT
ijpds-3217	236	1	wu	wu	PROPN
ijpds-3217	236	2	d	d	PROPN
ijpds-3217	236	3	,	,	PUNCT
ijpds-3217	236	4	wang	wang	PROPN
ijpds-3217	236	5	j	j	PROPN
ijpds-3217	236	6	,	,	PUNCT
ijpds-3217	236	7	liu	liu	PROPN
ijpds-3217	236	8	d	d	PROPN
ijpds-3217	236	9	,	,	PUNCT
ijpds-3217	236	10	zhang	zhang	PROPN
ijpds-3217	236	11	y	y	PROPN
ijpds-3217	236	12	,	,	PUNCT
ijpds-3217	236	13	hu	hu	PROPN
ijpds-3217	236	14	x.	x.	PROPN
ijpds-3217	236	15	computational	computational	ADJ
ijpds-3217	236	16	and	and	CCONJ
ijpds-3217	236	17	spectroscopic	spectroscopic	ADJ
ijpds-3217	236	18	analysis	analysis	NOUN
ijpds-3217	236	19	of	of	ADP
ijpds-3217	236	20	interaction	interaction	NOUN
ijpds-3217	236	21	between	between	ADP
ijpds-3217	236	22	food	food	NOUN
ijpds-3217	236	23	colorant	colorant	NOUN
ijpds-3217	236	24	citrus	citrus	NOUN
ijpds-3217	236	25	soares	soar	VERB
ijpds-3217	236	26	et	et	PROPN
ijpds-3217	236	27	al	al	PROPN
ijpds-3217	236	28	hsa	hsa	PROPN
ijpds-3217	236	29	-	-	PUNCT
ijpds-3217	236	30	hctz	hctz	ADJ
ijpds-3217	236	31	interactions	interaction	NOUN
ijpds-3217	236	32	based	base	VERB
ijpds-3217	236	33	on	on	ADP
ijpds-3217	236	34	glucose	glucose	NOUN
ijpds-3217	236	35	concentrations	concentration	NOUN
ijpds-3217	236	36	vol	vol	NOUN
ijpds-3217	236	37	1	1	NUM
ijpds-3217	236	38	|	|	NOUN
ijpds-3217	236	39	issue	issue	NOUN
ijpds-3217	236	40	2	2	NUM
ijpds-3217	237	1	|	|	ADV
ijpds-3217	237	2	jul	jul	PROPN
ijpds-3217	237	3	sep	sep	PROPN
ijpds-3217	237	4	2022	2022	NUM
ijpds-3217	237	5	indian	indian	PROPN
ijpds-3217	237	6	j	j	PROPN
ijpds-3217	237	7	pharm	pharm	PROPN
ijpds-3217	237	8	drug	drug	PROPN
ijpds-3217	237	9	studies	study	NOUN
ijpds-3217	237	10	|	|	ADV
ijpds-3217	237	11	62	62	NUM
ijpds-3217	237	12	red	red	ADJ
ijpds-3217	237	13	2	2	NUM
ijpds-3217	237	14	and	and	CCONJ
ijpds-3217	237	15	human	human	ADJ
ijpds-3217	237	16	serum	serum	NOUN
ijpds-3217	237	17	albumin	albumin	PROPN
ijpds-3217	237	18	.	.	PUNCT
ijpds-3217	238	1	scientific	scientific	ADJ
ijpds-3217	238	2	reports	report	NOUN
ijpds-3217	238	3	.	.	PUNCT
ijpds-3217	239	1	2019a	2019a	NUM
ijpds-3217	239	2	;	;	PUNCT
ijpds-3217	239	3	9	9	NUM
ijpds-3217	239	4	:	:	SYM
ijpds-3217	239	5	1615	1615	NUM
ijpds-3217	239	6	.	.	PUNCT
ijpds-3217	240	1	31	31	NUM
ijpds-3217	240	2	.	.	PUNCT
ijpds-3217	241	1	mohamadi	mohamadi	PROPN
ijpds-3217	241	2	nejad	nejad	PROPN
ijpds-3217	241	3	a	a	PROPN
ijpds-3217	241	4	,	,	PUNCT
ijpds-3217	241	5	moosavi	moosavi	ADJ
ijpds-3217	241	6	movahedi	movahedi	PROPN
ijpds-3217	241	7	a.a	a.a	PROPN
ijpds-3217	241	8	,	,	PUNCT
ijpds-3217	241	9	hakimelahi	hakimelahi	PROPN
ijpds-3217	241	10	,	,	PUNCT
ijpds-3217	241	11	g.h	g.h	PROPN
ijpds-3217	241	12	,	,	PUNCT
ijpds-3217	241	13	et	et	PROPN
ijpds-3217	241	14	al	al	PROPN
ijpds-3217	241	15	.	.	PUNCT
ijpds-3217	242	1	thermodynamic	thermodynamic	ADJ
ijpds-3217	242	2	analysis	analysis	NOUN
ijpds-3217	242	3	of	of	ADP
ijpds-3217	242	4	human	human	ADJ
ijpds-3217	242	5	serum	serum	NOUN
ijpds-3217	242	6	albumin	albumin	ADJ
ijpds-3217	242	7	interactions	interaction	NOUN
ijpds-3217	242	8	with	with	ADP
ijpds-3217	242	9	glucose	glucose	NOUN
ijpds-3217	242	10	:	:	PUNCT
ijpds-3217	242	11	insights	insight	NOUN
ijpds-3217	242	12	into	into	ADP
ijpds-3217	242	13	the	the	DET
ijpds-3217	242	14	diabetic	diabetic	ADJ
ijpds-3217	242	15	range	range	NOUN
ijpds-3217	242	16	of	of	ADP
ijpds-3217	242	17	glucose	glucose	NOUN
ijpds-3217	242	18	concentration	concentration	NOUN
ijpds-3217	242	19	.	.	PUNCT
ijpds-3217	243	1	int	int	NOUN
ijpds-3217	243	2	.	.	PUNCT
ijpds-3217	244	1	j.	j.	PROPN
ijpds-3217	244	2	biochem	biochem	PROPN
ijpds-3217	244	3	.	.	PUNCT
ijpds-3217	245	1	cell	cell	NOUN
ijpds-3217	245	2	biol	biol	PROPN
ijpds-3217	245	3	.	.	PUNCT
ijpds-3217	246	1	2002	2002	NUM
ijpds-3217	246	2	;	;	PUNCT
ijpds-3217	246	3	34	34	NUM
ijpds-3217	246	4	:	:	SYM
ijpds-3217	246	5	1115	1115	NUM
ijpds-3217	246	6	1124	1124	NUM
ijpds-3217	246	7	.	.	PUNCT
ijpds-3217	247	1	32	32	NUM
ijpds-3217	247	2	.	.	PUNCT
ijpds-3217	248	1	amanian	amanian	PROPN
ijpds-3217	248	2	azodi	azodi	PROPN
ijpds-3217	248	3	m	m	PROPN
ijpds-3217	248	4	,	,	PUNCT
ijpds-3217	248	5	rezaei	rezaei	PROPN
ijpds-3217	248	6	tavirani	tavirani	PROPN
ijpds-3217	248	7	m	m	PROPN
ijpds-3217	248	8	,	,	PUNCT
ijpds-3217	248	9	vafaee	vafaee	PROPN
ijpds-3217	248	10	r.	r.	PROPN
ijpds-3217	248	11	critical	critical	ADJ
ijpds-3217	248	12	concentration	concentration	NOUN
ijpds-3217	248	13	of	of	ADP
ijpds-3217	248	14	glucose	glucose	NOUN
ijpds-3217	248	15	changes	change	NOUN
ijpds-3217	248	16	human	human	ADJ
ijpds-3217	248	17	serum	serum	NOUN
ijpds-3217	248	18	albumin	albumin	PROPN
ijpds-3217	248	19	conformation	conformation	NOUN
ijpds-3217	248	20	:	:	PUNCT
ijpds-3217	248	21	circular	circular	ADJ
ijpds-3217	248	22	dichroism	dichroism	NOUN
ijpds-3217	248	23	(	(	PUNCT
ijpds-3217	248	24	cd	cd	PROPN
ijpds-3217	248	25	)	)	PUNCT
ijpds-3217	248	26	and	and	CCONJ
ijpds-3217	248	27	uv	uv	NOUN
ijpds-3217	248	28	spectroscopy	spectroscopy	NOUN
ijpds-3217	248	29	approaches	approach	NOUN
ijpds-3217	248	30	.	.	PUNCT
ijpds-3217	249	1	j	j	PROPN
ijpds-3217	249	2	param	param	PROPN
ijpds-3217	249	3	sc	sc	PROPN
ijpds-3217	249	4	.	.	PROPN
ijpds-3217	249	5	2013	2013	NUM
ijpds-3217	249	6	;	;	PUNCT
ijpds-3217	249	7	4	4	NUM
ijpds-3217	249	8	:	:	SYM
ijpds-3217	249	9	56	56	NUM
ijpds-3217	249	10	61	61	NUM
ijpds-3217	249	11	.	.	PUNCT
ijpds-3217	250	1	33	33	NUM
ijpds-3217	250	2	.	.	PUNCT
ijpds-3217	250	3	gull	gull	PROPN
ijpds-3217	250	4	n	n	CCONJ
ijpds-3217	250	5	,	,	PUNCT
ijpds-3217	250	6	sen	sen	PROPN
ijpds-3217	250	7	p	p	PROPN
ijpds-3217	250	8	,	,	PUNCT
ijpds-3217	250	9	khan	khan	PROPN
ijpds-3217	250	10	r.h	r.h	PROPN
ijpds-3217	250	11	,	,	PUNCT
ijpds-3217	250	12	et	et	PROPN
ijpds-3217	250	13	al	al	PROPN
ijpds-3217	250	14	.	.	PROPN
ijpds-3217	250	15	spectroscopic	spectroscopic	ADJ
ijpds-3217	250	16	studies	study	NOUN
ijpds-3217	250	17	on	on	ADP
ijpds-3217	250	18	the	the	DET
ijpds-3217	250	19	comparative	comparative	ADJ
ijpds-3217	250	20	interaction	interaction	NOUN
ijpds-3217	250	21	of	of	ADP
ijpds-3217	250	22	cationic	cationic	ADJ
ijpds-3217	250	23	single	single	ADJ
ijpds-3217	250	24	-	-	PUNCT
ijpds-3217	250	25	chain	chain	NOUN
ijpds-3217	250	26	and	and	CCONJ
ijpds-3217	250	27	gemini	gemini	NOUN
ijpds-3217	250	28	surfactants	surfactant	NOUN
ijpds-3217	250	29	with	with	ADP
ijpds-3217	250	30	human	human	ADJ
ijpds-3217	250	31	serum	serum	NOUN
ijpds-3217	250	32	albumin	albumin	PROPN
ijpds-3217	250	33	.	.	PUNCT
ijpds-3217	251	1	j	j	PROPN
ijpds-3217	251	2	biochem	biochem	PROPN
ijpds-3217	251	3	.	.	PUNCT
ijpds-3217	252	1	2009	2009	NUM
ijpds-3217	252	2	;	;	PUNCT
ijpds-3217	252	3	145	145	NUM
ijpds-3217	252	4	:	:	SYM
ijpds-3217	252	5	67	67	NUM
ijpds-3217	252	6	77	77	NUM
ijpds-3217	252	7	.	.	PUNCT
ijpds-3217	253	1	34	34	NUM
ijpds-3217	253	2	.	.	PUNCT
ijpds-3217	253	3	ziv	ziv	PROPN
ijpds-3217	253	4	g	g	PROPN
ijpds-3217	253	5	,	,	PUNCT
ijpds-3217	253	6	thirumalai	thirumalai	NOUN
ijpds-3217	253	7	d	d	PROPN
ijpds-3217	253	8	,	,	PUNCT
ijpds-3217	253	9	haran	haran	PROPN
ijpds-3217	253	10	g.	g.	PROPN
ijpds-3217	253	11	collapse	collapse	PROPN
ijpds-3217	253	12	transition	transition	NOUN
ijpds-3217	253	13	in	in	ADP
ijpds-3217	253	14	proteins	protein	NOUN
ijpds-3217	253	15	.	.	PUNCT
ijpds-3217	254	1	phys	phy	NOUN
ijpds-3217	254	2	chem	chem	VERB
ijpds-3217	254	3	chem	chem	NOUN
ijpds-3217	254	4	phys	phy	NOUN
ijpds-3217	254	5	.	.	PUNCT
ijpds-3217	255	1	2009	2009	NUM
ijpds-3217	255	2	;	;	PUNCT
ijpds-3217	255	3	11	11	NUM
ijpds-3217	255	4	:	:	SYM
ijpds-3217	255	5	83	83	NUM
ijpds-3217	255	6	93	93	NUM
ijpds-3217	255	7	.	.	PUNCT
ijpds-3217	256	1	35	35	NUM
ijpds-3217	256	2	.	.	PUNCT
ijpds-3217	257	1	matei	matei	PROPN
ijpds-3217	257	2	i	i	PROPN
ijpds-3217	257	3	,	,	PUNCT
ijpds-3217	257	4	buta	buta	PROPN
ijpds-3217	257	5	c.m	c.m	PROPN
ijpds-3217	257	6	,	,	PUNCT
ijpds-3217	257	7	turcu	turcu	NOUN
ijpds-3217	257	8	i.m	i.m	PROPN
ijpds-3217	257	9	,	,	PUNCT
ijpds-3217	257	10	et	et	PROPN
ijpds-3217	257	11	al	al	PROPN
ijpds-3217	257	12	.	.	PUNCT
ijpds-3217	257	13	formation	formation	NOUN
ijpds-3217	257	14	and	and	CCONJ
ijpds-3217	257	15	stabilization	stabilization	NOUN
ijpds-3217	257	16	of	of	ADP
ijpds-3217	257	17	gold	gold	ADJ
ijpds-3217	257	18	nanoparticles	nanoparticle	NOUN
ijpds-3217	257	19	in	in	ADP
ijpds-3217	257	20	bovine	bovine	NOUN
ijpds-3217	257	21	serum	serum	NOUN
ijpds-3217	257	22	albumin	albumin	ADJ
ijpds-3217	257	23	solution	solution	NOUN
ijpds-3217	257	24	.	.	PUNCT
ijpds-3217	258	1	molecules	molecule	NOUN
ijpds-3217	258	2	.	.	PUNCT
ijpds-3217	259	1	2019	2019	NUM
ijpds-3217	259	2	;	;	PUNCT
ijpds-3217	259	3	24	24	NUM
ijpds-3217	259	4	:	:	SYM
ijpds-3217	259	5	3395	3395	NUM
ijpds-3217	259	6	3409	3409	NUM
ijpds-3217	259	7	.	.	PUNCT
ijpds-3217	260	1	36	36	NUM
ijpds-3217	260	2	.	.	X
ijpds-3217	260	3	tang	tang	PROPN
ijpds-3217	260	4	b	b	PROPN
ijpds-3217	260	5	,	,	PUNCT
ijpds-3217	260	6	huang	huang	PROPN
ijpds-3217	260	7	y	y	PROPN
ijpds-3217	260	8	,	,	PUNCT
ijpds-3217	260	9	ma	ma	PROPN
ijpds-3217	260	10	x	x	PROPN
ijpds-3217	260	11	,	,	PUNCT
ijpds-3217	260	12	et	et	PROPN
ijpds-3217	260	13	al	al	PROPN
ijpds-3217	260	14	.	.	PROPN
ijpds-3217	260	15	multispectroscopic	multispectroscopic	NOUN
ijpds-3217	260	16	and	and	CCONJ
ijpds-3217	260	17	docking	dock	VERB
ijpds-3217	260	18	studies	study	NOUN
ijpds-3217	260	19	on	on	ADP
ijpds-3217	260	20	the	the	DET
ijpds-3217	260	21	binding	binding	NOUN
ijpds-3217	260	22	of	of	ADP
ijpds-3217	260	23	chlorogenic	chlorogenic	ADJ
ijpds-3217	260	24	acid	acid	NOUN
ijpds-3217	260	25	isomers	isomer	NOUN
ijpds-3217	260	26	to	to	ADP
ijpds-3217	260	27	human	human	ADJ
ijpds-3217	260	28	serum	serum	NOUN
ijpds-3217	260	29	albumin	albumin	NOUN
ijpds-3217	260	30	:	:	PUNCT
ijpds-3217	260	31	effects	effect	NOUN
ijpds-3217	260	32	of	of	ADP
ijpds-3217	260	33	esteryl	esteryl	NOUN
ijpds-3217	260	34	position	position	NOUN
ijpds-3217	260	35	on	on	ADP
ijpds-3217	260	36	affinity	affinity	NOUN
ijpds-3217	260	37	.	.	PUNCT
ijpds-3217	261	1	food	food	NOUN
ijpds-3217	261	2	chem	chem	NOUN
ijpds-3217	261	3	.	.	PUNCT
ijpds-3217	262	1	2016	2016	NUM
ijpds-3217	262	2	;	;	PUNCT
ijpds-3217	262	3	212	212	NUM
ijpds-3217	262	4	:	:	SYM
ijpds-3217	262	5	434	434	NUM
ijpds-3217	262	6	442	442	NUM
ijpds-3217	262	7	.	.	PUNCT
ijpds-3217	263	1	37	37	NUM
ijpds-3217	263	2	.	.	PUNCT
ijpds-3217	264	1	chaves	chaves	PROPN
ijpds-3217	264	2	o.a	o.a	PROPN
ijpds-3217	264	3	,	,	PUNCT
ijpds-3217	264	4	menezes	menezes	PROPN
ijpds-3217	264	5	l.b	l.b	PROPN
ijpds-3217	264	6	,	,	PUNCT
ijpds-3217	264	7	iglesias	iglesias	PROPN
ijpds-3217	264	8	b.a	b.a	PROPN
ijpds-3217	264	9	.	.	PROPN
ijpds-3217	264	10	multiple	multiple	ADJ
ijpds-3217	264	11	spectroscopic	spectroscopic	ADJ
ijpds-3217	264	12	and	and	CCONJ
ijpds-3217	264	13	theoretical	theoretical	ADJ
ijpds-3217	264	14	investigation	investigation	NOUN
ijpds-3217	264	15	of	of	ADP
ijpds-3217	264	16	meso	meso	ADJ
ijpds-3217	264	17	tetra	tetra	NOUN
ijpds-3217	264	18	(	(	PUNCT
ijpds-3217	264	19	4	4	NUM
ijpds-3217	264	20	-	-	PUNCT
ijpds-3217	264	21	pyridyl	pyridyl	NOUN
ijpds-3217	264	22	)	)	PUNCT
ijpds-3217	264	23	porphyrin	porphyrin	NOUN
ijpds-3217	264	24	ruthenium	ruthenium	NOUN
ijpds-3217	264	25	(	(	PUNCT
ijpds-3217	264	26	ii	ii	NOUN
ijpds-3217	264	27	)	)	PUNCT
ijpds-3217	264	28	complexes	complex	NOUN
ijpds-3217	264	29	in	in	ADP
ijpds-3217	264	30	hsa	hsa	PROPN
ijpds-3217	264	31	-	-	PUNCT
ijpds-3217	264	32	binding	bind	VERB
ijpds-3217	264	33	studies	study	NOUN
ijpds-3217	264	34	.	.	PUNCT
ijpds-3217	265	1	effect	effect	NOUN
ijpds-3217	265	2	of	of	ADP
ijpds-3217	265	3	zn	zn	PROPN
ijpds-3217	265	4	(	(	PUNCT
ijpds-3217	265	5	ii	ii	PROPN
ijpds-3217	265	6	)	)	PUNCT
ijpds-3217	265	7	in	in	ADP
ijpds-3217	265	8	protein	protein	NOUN
ijpds-3217	265	9	binding	bind	VERB
ijpds-3217	265	10	.	.	PUNCT
ijpds-3217	266	1	j	j	PROPN
ijpds-3217	266	2	mol	mol	ADP
ijpds-3217	266	3	liq	liq	NOUN
ijpds-3217	266	4	.	.	PUNCT
ijpds-3217	266	5	2019	2019	NUM
ijpds-3217	266	6	;	;	PUNCT
ijpds-3217	266	7	294	294	NUM
ijpds-3217	266	8	:	:	PUNCT
ijpds-3217	266	9	111581	111581	NUM
ijpds-3217	266	10	.	.	PUNCT
ijpds-3217	267	1	38	38	NUM
ijpds-3217	267	2	.	.	PUNCT
ijpds-3217	268	1	oliva	oliva	PROPN
ijpds-3217	268	2	l	l	PROPN
ijpds-3217	268	3	,	,	PUNCT
ijpds-3217	268	4	fernandez	fernandez	PROPN
ijpds-3217	268	5	lopez	lopez	PROPN
ijpds-3217	268	6	j.a	j.a	PROPN
ijpds-3217	268	7	,	,	PUNCT
ijpds-3217	268	8	remesar	remesar	VERB
ijpds-3217	268	9	x	x	X
ijpds-3217	268	10	,	,	PUNCT
ijpds-3217	268	11	et	et	PROPN
ijpds-3217	268	12	al	al	PROPN
ijpds-3217	268	13	.	.	PUNCT
ijpds-3217	269	1	the	the	DET
ijpds-3217	269	2	anomeric	anomeric	ADJ
ijpds-3217	269	3	nature	nature	NOUN
ijpds-3217	269	4	of	of	ADP
ijpds-3217	269	5	glucose	glucose	NOUN
ijpds-3217	269	6	and	and	CCONJ
ijpds-3217	269	7	its	its	PRON
ijpds-3217	269	8	implications	implication	NOUN
ijpds-3217	269	9	on	on	ADP
ijpds-3217	269	10	its	its	PRON
ijpds-3217	269	11	analyses	analysis	NOUN
ijpds-3217	269	12	and	and	CCONJ
ijpds-3217	269	13	the	the	DET
ijpds-3217	269	14	influence	influence	NOUN
ijpds-3217	269	15	of	of	ADP
ijpds-3217	269	16	diet	diet	NOUN
ijpds-3217	269	17	:	:	PUNCT
ijpds-3217	269	18	are	be	AUX
ijpds-3217	269	19	routine	routine	ADJ
ijpds-3217	269	20	glycemia	glycemia	NOUN
ijpds-3217	269	21	measurements	measurement	NOUN
ijpds-3217	269	22	reliable	reliable	ADJ
ijpds-3217	269	23	enough	enough	ADV
ijpds-3217	269	24	?	?	PUNCT
ijpds-3217	270	1	j	j	PROPN
ijpds-3217	270	2	endocrinol	endocrinol	NOUN
ijpds-3217	270	3	metabol	metabol	NOUN
ijpds-3217	270	4	.	.	PUNCT
ijpds-3217	271	1	2019	2019	NUM
ijpds-3217	271	2	;	;	PUNCT
ijpds-3217	271	3	9	9	NUM
ijpds-3217	271	4	:	:	SYM
ijpds-3217	271	5	63	63	NUM
ijpds-3217	271	6	70	70	NUM
ijpds-3217	271	7	.	.	PUNCT
ijpds-3217	272	1	39	39	NUM
ijpds-3217	272	2	.	.	PUNCT
ijpds-3217	273	1	kuriyan	kuriyan	PROPN
ijpds-3217	273	2	j	j	PROPN
ijpds-3217	273	3	,	,	PUNCT
ijpds-3217	273	4	konforti	konforti	PROPN
ijpds-3217	273	5	b	b	PROPN
ijpds-3217	273	6	,	,	PUNCT
ijpds-3217	273	7	wemmer	wemmer	PROPN
ijpds-3217	273	8	d.	d.	PROPN
ijpds-3217	273	9	the	the	DET
ijpds-3217	273	10	molecules	molecule	NOUN
ijpds-3217	273	11	of	of	ADP
ijpds-3217	273	12	life	life	NOUN
ijpds-3217	273	13	.	.	PUNCT
ijpds-3217	274	1	1st	1st	ADJ
ijpds-3217	274	2	ed	ed	NOUN
ijpds-3217	274	3	.	.	PROPN
ijpds-3217	274	4	,	,	PUNCT
ijpds-3217	274	5	taylor	taylor	PROPN
ijpds-3217	274	6	&	&	CCONJ
ijpds-3217	274	7	francis	francis	PROPN
ijpds-3217	274	8	group	group	PROPN
ijpds-3217	274	9	,	,	PUNCT
ijpds-3217	274	10	2013	2013	NUM
ijpds-3217	274	11	.	.	PUNCT
ijpds-3217	275	1	how	how	SCONJ
ijpds-3217	275	2	to	to	PART
ijpds-3217	275	3	cite	cite	VERB
ijpds-3217	275	4	this	this	DET
ijpds-3217	275	5	article	article	NOUN
ijpds-3217	275	6	:	:	PUNCT
ijpds-3217	275	7	marilia	marilia	PROPN
ijpds-3217	275	8	amável	amável	PROPN
ijpds-3217	275	9	gomes	gomes	PROPN
ijpds-3217	275	10	soares	soares	PROPN
ijpds-3217	275	11	,	,	PUNCT
ijpds-3217	275	12	otávio	otávio	NOUN
ijpds-3217	275	13	augusto	augusto	PROPN
ijpds-3217	275	14	chaves	chave	NOUN
ijpds-3217	275	15	,	,	PUNCT
ijpds-3217	275	16	antônio	antônio	PROPN
ijpds-3217	275	17	augusto	augusto	PROPN
ijpds-3217	275	18	fidalgo	fidalgo	PROPN
ijpds-3217	275	19	neto	neto	PROPN
ijpds-3217	275	20	,	,	PUNCT
ijpds-3217	275	21	dilson	dilson	NOUN
ijpds-3217	275	22	silva	silva	PROPN
ijpds-3217	275	23	,	,	PUNCT
ijpds-3217	275	24	dari	dari	PROPN
ijpds-3217	275	25	cesarin	cesarin	PROPN
ijpds-3217	275	26	-	-	PUNCT
ijpds-3217	275	27	sobrinho	sobrinho	NOUN
ijpds-3217	275	28	,	,	PUNCT
ijpds-3217	275	29	célia	célia	PROPN
ijpds-3217	275	30	martins	martins	PROPN
ijpds-3217	275	31	cortez	cortez	PROPN
ijpds-3217	275	32	.	.	PUNCT
ijpds-3217	276	1	effect	effect	NOUN
ijpds-3217	276	2	of	of	ADP
ijpds-3217	276	3	glucose	glucose	NOUN
ijpds-3217	276	4	concentrations	concentration	NOUN
ijpds-3217	276	5	on	on	ADP
ijpds-3217	276	6	the	the	DET
ijpds-3217	276	7	hsahydrochlorothiazide	hsahydrochlorothiazide	ADJ
ijpds-3217	276	8	interaction	interaction	NOUN
ijpds-3217	276	9	–	–	PUNCT
ijpds-3217	276	10	a	a	DET
ijpds-3217	276	11	study	study	NOUN
ijpds-3217	276	12	using	use	VERB
ijpds-3217	276	13	circular	circular	ADJ
ijpds-3217	276	14	dichroism	dichroism	NOUN
ijpds-3217	276	15	and	and	CCONJ
ijpds-3217	276	16	molecular	molecular	ADJ
ijpds-3217	276	17	docking	docking	NOUN
ijpds-3217	276	18	.	.	PUNCT
ijpds-3217	277	1	indian	indian	PROPN
ijpds-3217	277	2	j	j	PROPN
ijpds-3217	277	3	pharm	pharm	PROPN
ijpds-3217	277	4	drug	drug	PROPN
ijpds-3217	277	5	studies	study	NOUN
ijpds-3217	277	6	.	.	PUNCT
ijpds-3217	278	1	2022	2022	NUM
ijpds-3217	278	2	:	:	PUNCT
ijpds-3217	278	3	1(2	1(2	NUM
ijpds-3217	278	4	)	)	PUNCT
ijpds-3217	278	5	56	56	NUM
ijpds-3217	278	6	-	-	SYM
ijpds-3217	278	7	62	62	NUM
ijpds-3217	278	8	.	.	PUNCT
ijpds-3217	279	1	funding	funding	NOUN
ijpds-3217	279	2	:	:	PUNCT
ijpds-3217	279	3	none	none	NOUN
ijpds-3217	279	4	conflict	conflict	NOUN
ijpds-3217	279	5	of	of	ADP
ijpds-3217	279	6	interest	interest	NOUN
ijpds-3217	279	7	:	:	PUNCT
ijpds-3217	279	8	none	none	NOUN
ijpds-3217	279	9	stated	state	VERB