id	sid	tid	token	lemma	pos
ijpds-3935	1	1	shanbhag	shanbhag	NOUN
ijpds-3935	1	2	et	et	PROPN
ijpds-3935	1	3	al	al	PROPN
ijpds-3935	1	4	.	.	PUNCT
ijpds-3935	1	5	cancer	cancer	NOUN
ijpds-3935	1	6	therapy	therapy	NOUN
ijpds-3935	1	7	:	:	PUNCT
ijpds-3935	1	8	an	an	DET
ijpds-3935	1	9	overview	overview	NOUN
ijpds-3935	1	10	of	of	ADP
ijpds-3935	1	11	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	1	12	strategies	strategy	NOUN
ijpds-3935	1	13	vol	vol	VERB
ijpds-3935	1	14	2|	2|	NUM
ijpds-3935	1	15	issue	issue	NOUN
ijpds-3935	1	16	2	2	NUM
ijpds-3935	1	17	|	|	ADV
ijpds-3935	1	18	apr	apr	ADV
ijpds-3935	1	19	–	–	PUNCT
ijpds-3935	1	20	jun	jun	PROPN
ijpds-3935	1	21	2023	2023	NUM
ijpds-3935	1	22	indian	indian	PROPN
ijpds-3935	1	23	j	j	PROPN
ijpds-3935	1	24	pharm	pharm	PROPN
ijpds-3935	1	25	drug	drug	PROPN
ijpds-3935	1	26	studies	study	NOUN
ijpds-3935	1	27	|	|	ADV
ijpds-3935	1	28	63	63	NUM
ijpds-3935	1	29	review	review	NOUN
ijpds-3935	1	30	article	article	NOUN
ijpds-3935	1	31	the	the	DET
ijpds-3935	1	32	potential	potential	NOUN
ijpds-3935	1	33	of	of	ADP
ijpds-3935	1	34	sirna	sirna	PROPN
ijpds-3935	1	35	-	-	PUNCT
ijpds-3935	1	36	mediated	mediate	VERB
ijpds-3935	1	37	oncogene	oncogene	NOUN
ijpds-3935	1	38	silencing	silence	VERB
ijpds-3935	1	39	in	in	ADP
ijpds-3935	1	40	cancer	cancer	NOUN
ijpds-3935	1	41	therapy	therapy	NOUN
ijpds-3935	1	42	:	:	PUNCT
ijpds-3935	1	43	an	an	DET
ijpds-3935	1	44	overview	overview	NOUN
ijpds-3935	1	45	of	of	ADP
ijpds-3935	1	46	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	1	47	strategies	strategy	NOUN
ijpds-3935	1	48	preeti	preeti	PROPN
ijpds-3935	1	49	shanbhag1	shanbhag1	PROPN
ijpds-3935	1	50	,	,	PUNCT
ijpds-3935	1	51	ramdas	ramdas	PROPN
ijpds-3935	1	52	bhat2	bhat2	PROPN
ijpds-3935	1	53	,	,	PUNCT
ijpds-3935	1	54	a	a	DET
ijpds-3935	1	55	r	r	NOUN
ijpds-3935	1	56	shabaraya3	shabaraya3	NOUN
ijpds-3935	1	57	from	from	ADP
ijpds-3935	1	58	1pg	1pg	ADJ
ijpds-3935	1	59	scholar	scholar	NOUN
ijpds-3935	1	60	,	,	PUNCT
ijpds-3935	1	61	2assistant	2assistant	NUM
ijpds-3935	1	62	professor	professor	NOUN
ijpds-3935	1	63	,	,	PUNCT
ijpds-3935	1	64	department	department	NOUN
ijpds-3935	1	65	of	of	ADP
ijpds-3935	1	66	pharmacology	pharmacology	NOUN
ijpds-3935	1	67	,	,	PUNCT
ijpds-3935	1	68	3principle	3principle	NUM
ijpds-3935	1	69	and	and	CCONJ
ijpds-3935	1	70	head	head	NOUN
ijpds-3935	1	71	of	of	ADP
ijpds-3935	1	72	the	the	DET
ijpds-3935	1	73	department	department	NOUN
ijpds-3935	1	74	of	of	ADP
ijpds-3935	1	75	pharmaceutics	pharmaceutic	NOUN
ijpds-3935	1	76	,	,	PUNCT
ijpds-3935	1	77	srinivas	srinivas	PROPN
ijpds-3935	1	78	college	college	PROPN
ijpds-3935	1	79	of	of	ADP
ijpds-3935	1	80	pharmacy	pharmacy	NOUN
ijpds-3935	1	81	,	,	PUNCT
ijpds-3935	1	82	valachil	valachil	NOUN
ijpds-3935	1	83	,	,	PUNCT
ijpds-3935	1	84	post	post	NOUN
ijpds-3935	1	85	farangipete	farangipete	NOUN
ijpds-3935	1	86	,	,	PUNCT
ijpds-3935	1	87	mangalore	mangalore	PROPN
ijpds-3935	1	88	,	,	PUNCT
ijpds-3935	1	89	karnataka	karnataka	ADJ
ijpds-3935	1	90	,	,	PUNCT
ijpds-3935	1	91	india-574143	india-574143	NOUN
ijpds-3935	1	92	.	.	PUNCT
ijpds-3935	2	1	correspondence	correspondence	NOUN
ijpds-3935	2	2	to	to	ADP
ijpds-3935	2	3	:	:	PUNCT
ijpds-3935	2	4	ramdas	ramdas	PROPN
ijpds-3935	2	5	bhat	bhat	PROPN
ijpds-3935	2	6	,	,	PUNCT
ijpds-3935	2	7	assistant	assistant	NOUN
ijpds-3935	2	8	professor	professor	NOUN
ijpds-3935	2	9	,	,	PUNCT
ijpds-3935	2	10	department	department	NOUN
ijpds-3935	2	11	of	of	ADP
ijpds-3935	2	12	pharmacology	pharmacology	NOUN
ijpds-3935	2	13	,	,	PUNCT
ijpds-3935	2	14	srinivas	srinivas	PROPN
ijpds-3935	2	15	college	college	PROPN
ijpds-3935	2	16	of	of	ADP
ijpds-3935	2	17	pharmacy	pharmacy	NOUN
ijpds-3935	2	18	,	,	PUNCT
ijpds-3935	2	19	valachil	valachil	NOUN
ijpds-3935	2	20	,	,	PUNCT
ijpds-3935	2	21	post	post	NOUN
ijpds-3935	2	22	farangipete	farangipete	NOUN
ijpds-3935	2	23	,	,	PUNCT
ijpds-3935	2	24	mangalore	mangalore	PROPN
ijpds-3935	2	25	,	,	PUNCT
ijpds-3935	2	26	karnataka	karnataka	PROPN
ijpds-3935	2	27	,	,	PUNCT
ijpds-3935	2	28	india	india	PROPN
ijpds-3935	2	29	.	.	PUNCT
ijpds-3935	2	30	email	email	NOUN
ijpds-3935	2	31	:	:	PUNCT
ijpds-3935	2	32	ramdas21@gmail.com	ramdas21@gmail.com	PROPN
ijpds-3935	2	33	tel	tel	PROPN
ijpds-3935	2	34	.	.	PUNCT
ijpds-3935	2	35	:	:	PUNCT
ijpds-3935	3	1	+91	+91	NOUN
ijpds-3935	3	2	7795772463	7795772463	NUM
ijpds-3935	3	3	abstract	abstract	ADJ
ijpds-3935	3	4	sirna	sirna	PROPN
ijpds-3935	3	5	-	-	PUNCT
ijpds-3935	3	6	mediated	mediate	VERB
ijpds-3935	3	7	silencing	silencing	NOUN
ijpds-3935	3	8	of	of	ADP
ijpds-3935	3	9	oncogenes	oncogene	NOUN
ijpds-3935	3	10	holds	hold	VERB
ijpds-3935	3	11	great	great	ADJ
ijpds-3935	3	12	promise	promise	NOUN
ijpds-3935	3	13	as	as	ADP
ijpds-3935	3	14	a	a	DET
ijpds-3935	3	15	potential	potential	ADJ
ijpds-3935	3	16	cancer	cancer	NOUN
ijpds-3935	3	17	therapy	therapy	NOUN
ijpds-3935	3	18	.	.	PUNCT
ijpds-3935	4	1	by	by	ADP
ijpds-3935	4	2	selectively	selectively	ADV
ijpds-3935	4	3	silencing	silence	VERB
ijpds-3935	4	4	genes	gene	NOUN
ijpds-3935	4	5	involved	involve	VERB
ijpds-3935	4	6	in	in	ADP
ijpds-3935	4	7	cancer	cancer	NOUN
ijpds-3935	4	8	progression	progression	NOUN
ijpds-3935	4	9	,	,	PUNCT
ijpds-3935	4	10	sirna	sirna	PROPN
ijpds-3935	4	11	-	-	PUNCT
ijpds-3935	4	12	based	base	VERB
ijpds-3935	4	13	therapies	therapy	NOUN
ijpds-3935	4	14	have	have	VERB
ijpds-3935	4	15	the	the	DET
ijpds-3935	4	16	potential	potential	NOUN
ijpds-3935	4	17	to	to	PART
ijpds-3935	4	18	be	be	AUX
ijpds-3935	4	19	highly	highly	ADV
ijpds-3935	4	20	specific	specific	ADJ
ijpds-3935	4	21	and	and	CCONJ
ijpds-3935	4	22	effective	effective	ADJ
ijpds-3935	4	23	,	,	PUNCT
ijpds-3935	4	24	while	while	SCONJ
ijpds-3935	4	25	minimizing	minimize	VERB
ijpds-3935	4	26	off	off	ADP
ijpds-3935	4	27	-	-	PUNCT
ijpds-3935	4	28	target	target	NOUN
ijpds-3935	4	29	effects	effect	NOUN
ijpds-3935	4	30	and	and	CCONJ
ijpds-3935	4	31	toxicity	toxicity	NOUN
ijpds-3935	4	32	.	.	PUNCT
ijpds-3935	5	1	however	however	ADV
ijpds-3935	5	2	,	,	PUNCT
ijpds-3935	5	3	several	several	ADJ
ijpds-3935	5	4	challenges	challenge	NOUN
ijpds-3935	5	5	need	need	VERB
ijpds-3935	5	6	to	to	PART
ijpds-3935	5	7	be	be	AUX
ijpds-3935	5	8	addressed	address	VERB
ijpds-3935	5	9	before	before	SCONJ
ijpds-3935	5	10	sirna	sirna	PROPN
ijpds-3935	5	11	-	-	PUNCT
ijpds-3935	5	12	based	base	VERB
ijpds-3935	5	13	therapies	therapy	NOUN
ijpds-3935	5	14	can	can	AUX
ijpds-3935	5	15	be	be	AUX
ijpds-3935	5	16	widely	widely	ADV
ijpds-3935	5	17	used	use	VERB
ijpds-3935	5	18	in	in	ADP
ijpds-3935	5	19	clinical	clinical	ADJ
ijpds-3935	5	20	settings	setting	NOUN
ijpds-3935	5	21	.	.	PUNCT
ijpds-3935	6	1	one	one	NUM
ijpds-3935	6	2	of	of	ADP
ijpds-3935	6	3	the	the	DET
ijpds-3935	6	4	major	major	ADJ
ijpds-3935	6	5	challenges	challenge	NOUN
ijpds-3935	6	6	is	be	AUX
ijpds-3935	6	7	the	the	DET
ijpds-3935	6	8	development	development	NOUN
ijpds-3935	6	9	of	of	ADP
ijpds-3935	6	10	efficient	efficient	ADJ
ijpds-3935	6	11	and	and	CCONJ
ijpds-3935	6	12	safe	safe	ADJ
ijpds-3935	6	13	delivery	delivery	NOUN
ijpds-3935	6	14	systems	system	NOUN
ijpds-3935	6	15	for	for	ADP
ijpds-3935	6	16	sirnas	sirna	NOUN
ijpds-3935	6	17	.	.	PUNCT
ijpds-3935	7	1	additionally	additionally	ADV
ijpds-3935	7	2	,	,	PUNCT
ijpds-3935	7	3	more	more	ADV
ijpds-3935	7	4	clinical	clinical	ADJ
ijpds-3935	7	5	trials	trial	NOUN
ijpds-3935	7	6	are	be	AUX
ijpds-3935	7	7	needed	need	VERB
ijpds-3935	7	8	to	to	PART
ijpds-3935	7	9	evaluate	evaluate	VERB
ijpds-3935	7	10	the	the	DET
ijpds-3935	7	11	safety	safety	NOUN
ijpds-3935	7	12	and	and	CCONJ
ijpds-3935	7	13	efficacy	efficacy	NOUN
ijpds-3935	7	14	of	of	ADP
ijpds-3935	7	15	sirna	sirna	PROPN
ijpds-3935	7	16	-	-	PUNCT
ijpds-3935	7	17	based	base	VERB
ijpds-3935	7	18	therapies	therapy	NOUN
ijpds-3935	7	19	for	for	ADP
ijpds-3935	7	20	cancer	cancer	NOUN
ijpds-3935	7	21	treatment	treatment	NOUN
ijpds-3935	7	22	.	.	PUNCT
ijpds-3935	8	1	despite	despite	SCONJ
ijpds-3935	8	2	these	these	DET
ijpds-3935	8	3	challenges	challenge	NOUN
ijpds-3935	8	4	,	,	PUNCT
ijpds-3935	8	5	ongoing	ongoing	ADJ
ijpds-3935	8	6	research	research	NOUN
ijpds-3935	8	7	and	and	CCONJ
ijpds-3935	8	8	development	development	NOUN
ijpds-3935	8	9	in	in	ADP
ijpds-3935	8	10	the	the	DET
ijpds-3935	8	11	field	field	NOUN
ijpds-3935	8	12	of	of	ADP
ijpds-3935	8	13	sirna	sirna	PROPN
ijpds-3935	8	14	-	-	PUNCT
ijpds-3935	8	15	based	base	VERB
ijpds-3935	8	16	therapies	therapy	NOUN
ijpds-3935	8	17	are	be	AUX
ijpds-3935	8	18	promising	promise	VERB
ijpds-3935	8	19	.	.	PUNCT
ijpds-3935	9	1	new	new	ADJ
ijpds-3935	9	2	delivery	delivery	NOUN
ijpds-3935	9	3	systems	system	NOUN
ijpds-3935	9	4	,	,	PUNCT
ijpds-3935	9	5	personalized	personalize	VERB
ijpds-3935	9	6	medicine	medicine	NOUN
ijpds-3935	9	7	approaches	approach	NOUN
ijpds-3935	9	8	,	,	PUNCT
ijpds-3935	9	9	and	and	CCONJ
ijpds-3935	9	10	combination	combination	NOUN
ijpds-3935	9	11	therapies	therapy	NOUN
ijpds-3935	9	12	are	be	AUX
ijpds-3935	9	13	being	be	AUX
ijpds-3935	9	14	explored	explore	VERB
ijpds-3935	9	15	,	,	PUNCT
ijpds-3935	9	16	which	which	PRON
ijpds-3935	9	17	could	could	AUX
ijpds-3935	9	18	potentially	potentially	ADV
ijpds-3935	9	19	lead	lead	VERB
ijpds-3935	9	20	to	to	ADP
ijpds-3935	9	21	more	more	ADV
ijpds-3935	9	22	effective	effective	ADJ
ijpds-3935	9	23	and	and	CCONJ
ijpds-3935	9	24	personalized	personalized	ADJ
ijpds-3935	9	25	cancer	cancer	NOUN
ijpds-3935	9	26	treatment	treatment	NOUN
ijpds-3935	9	27	.	.	PUNCT
ijpds-3935	10	1	with	with	ADP
ijpds-3935	10	2	continued	continued	ADJ
ijpds-3935	10	3	research	research	NOUN
ijpds-3935	10	4	and	and	CCONJ
ijpds-3935	10	5	development	development	NOUN
ijpds-3935	10	6	,	,	PUNCT
ijpds-3935	10	7	it	it	PRON
ijpds-3935	10	8	is	be	AUX
ijpds-3935	10	9	hoped	hope	VERB
ijpds-3935	10	10	that	that	SCONJ
ijpds-3935	10	11	sirna	sirna	PROPN
ijpds-3935	10	12	-	-	PUNCT
ijpds-3935	10	13	based	base	VERB
ijpds-3935	10	14	therapies	therapy	NOUN
ijpds-3935	10	15	will	will	AUX
ijpds-3935	10	16	eventually	eventually	ADV
ijpds-3935	10	17	become	become	VERB
ijpds-3935	10	18	cancer	cancer	NOUN
ijpds-3935	10	19	treatments	treatment	NOUN
ijpds-3935	10	20	,	,	PUNCT
ijpds-3935	10	21	providing	provide	VERB
ijpds-3935	10	22	patients	patient	NOUN
ijpds-3935	10	23	with	with	ADP
ijpds-3935	10	24	a	a	DET
ijpds-3935	10	25	more	more	ADV
ijpds-3935	10	26	targeted	targeted	ADJ
ijpds-3935	10	27	and	and	CCONJ
ijpds-3935	10	28	effective	effective	ADJ
ijpds-3935	10	29	treatment	treatment	NOUN
ijpds-3935	10	30	option	option	NOUN
ijpds-3935	10	31	.	.	PUNCT
ijpds-3935	11	1	keywords	keyword	NOUN
ijpds-3935	11	2	:	:	PUNCT
ijpds-3935	12	1	sirna	sirna	PROPN
ijpds-3935	12	2	,	,	PUNCT
ijpds-3935	12	3	oncogenes	oncogene	NOUN
ijpds-3935	12	4	,	,	PUNCT
ijpds-3935	12	5	cancer	cancer	NOUN
ijpds-3935	12	6	therapy	therapy	NOUN
ijpds-3935	12	7	,	,	PUNCT
ijpds-3935	12	8	gene	gene	NOUN
ijpds-3935	12	9	silencing	silencing	NOUN
ijpds-3935	12	10	,	,	PUNCT
ijpds-3935	12	11	targeted	target	VERB
ijpds-3935	12	12	therapy	therapy	NOUN
ijpds-3935	12	13	,	,	PUNCT
ijpds-3935	12	14	delivery	delivery	NOUN
ijpds-3935	12	15	systems	system	NOUN
ijpds-3935	12	16	.	.	PUNCT
ijpds-3935	13	1	potent	potent	ADJ
ijpds-3935	13	2	biological	biological	ADJ
ijpds-3935	13	3	mechanism	mechanism	NOUN
ijpds-3935	13	4	called	call	VERB
ijpds-3935	13	5	rna	rna	NOUN
ijpds-3935	13	6	interference	interference	NOUN
ijpds-3935	13	7	(	(	PUNCT
ijpds-3935	13	8	rnai	rnai	PROPN
ijpds-3935	13	9	)	)	PUNCT
ijpds-3935	13	10	enables	enable	VERB
ijpds-3935	13	11	the	the	DET
ijpds-3935	13	12	post	post	ADJ
ijpds-3935	13	13	-	-	ADJ
ijpds-3935	13	14	transcriptional	transcriptional	ADJ
ijpds-3935	13	15	selective	selective	ADJ
ijpds-3935	13	16	suppression	suppression	NOUN
ijpds-3935	13	17	of	of	ADP
ijpds-3935	13	18	gene	gene	NOUN
ijpds-3935	13	19	expression	expression	NOUN
ijpds-3935	13	20	.	.	PUNCT
ijpds-3935	14	1	this	this	DET
ijpds-3935	14	2	mechanism	mechanism	NOUN
ijpds-3935	14	3	has	have	AUX
ijpds-3935	14	4	undergone	undergo	VERB
ijpds-3935	14	5	substantial	substantial	ADJ
ijpds-3935	14	6	research	research	NOUN
ijpds-3935	14	7	and	and	CCONJ
ijpds-3935	14	8	has	have	AUX
ijpds-3935	14	9	emerged	emerge	VERB
ijpds-3935	14	10	as	as	ADP
ijpds-3935	14	11	a	a	DET
ijpds-3935	14	12	potentially	potentially	ADV
ijpds-3935	14	13	useful	useful	ADJ
ijpds-3935	14	14	therapeutic	therapeutic	ADJ
ijpds-3935	14	15	tool	tool	NOUN
ijpds-3935	14	16	for	for	ADP
ijpds-3935	14	17	the	the	DET
ijpds-3935	14	18	management	management	NOUN
ijpds-3935	14	19	of	of	ADP
ijpds-3935	14	20	a	a	DET
ijpds-3935	14	21	number	number	NOUN
ijpds-3935	14	22	of	of	ADP
ijpds-3935	14	23	illnesses	illness	NOUN
ijpds-3935	14	24	,	,	PUNCT
ijpds-3935	14	25	including	include	VERB
ijpds-3935	14	26	cancer	cancer	NOUN
ijpds-3935	14	27	[	[	X
ijpds-3935	14	28	1	1	NUM
ijpds-3935	14	29	]	]	PUNCT
ijpds-3935	14	30	.	.	PUNCT
ijpds-3935	15	1	small	small	ADJ
ijpds-3935	15	2	interfering	interfere	VERB
ijpds-3935	15	3	rnas	rna	NOUN
ijpds-3935	15	4	(	(	PUNCT
ijpds-3935	15	5	sirnas	sirnas	PROPN
ijpds-3935	15	6	)	)	PUNCT
ijpds-3935	15	7	are	be	AUX
ijpds-3935	15	8	double	double	ADJ
ijpds-3935	15	9	-	-	PUNCT
ijpds-3935	15	10	stranded	strand	VERB
ijpds-3935	15	11	rna	rna	NOUN
ijpds-3935	15	12	molecules	molecule	NOUN
ijpds-3935	15	13	that	that	PRON
ijpds-3935	15	14	target	target	VERB
ijpds-3935	15	15	and	and	CCONJ
ijpds-3935	15	16	degrade	degrade	VERB
ijpds-3935	15	17	particular	particular	ADJ
ijpds-3935	15	18	mrna	mrna	NOUN
ijpds-3935	15	19	regions	region	NOUN
ijpds-3935	15	20	to	to	PART
ijpds-3935	15	21	silence	silence	VERB
ijpds-3935	15	22	genes	gene	NOUN
ijpds-3935	15	23	.	.	PUNCT
ijpds-3935	16	1	oncogenes	oncogene	NOUN
ijpds-3935	16	2	,	,	PUNCT
ijpds-3935	16	3	which	which	PRON
ijpds-3935	16	4	are	be	AUX
ijpds-3935	16	5	genes	gene	NOUN
ijpds-3935	16	6	that	that	PRON
ijpds-3935	16	7	promote	promote	VERB
ijpds-3935	16	8	the	the	DET
ijpds-3935	16	9	growth	growth	NOUN
ijpds-3935	16	10	and	and	CCONJ
ijpds-3935	16	11	proliferation	proliferation	NOUN
ijpds-3935	16	12	of	of	ADP
ijpds-3935	16	13	cancer	cancer	NOUN
ijpds-3935	16	14	cells	cell	NOUN
ijpds-3935	16	15	,	,	PUNCT
ijpds-3935	16	16	have	have	AUX
ijpds-3935	16	17	been	be	AUX
ijpds-3935	16	18	discovered	discover	VERB
ijpds-3935	16	19	as	as	ADP
ijpds-3935	16	20	promising	promise	VERB
ijpds-3935	16	21	targets	target	NOUN
ijpds-3935	16	22	for	for	ADP
ijpds-3935	16	23	sirna	sirna	NOUN
ijpds-3935	16	24	-	-	PUNCT
ijpds-3935	16	25	mediated	mediate	VERB
ijpds-3935	16	26	gene	gene	NOUN
ijpds-3935	16	27	silencing	silence	VERB
ijpds-3935	16	28	in	in	ADP
ijpds-3935	16	29	cancer	cancer	NOUN
ijpds-3935	16	30	therapy	therapy	NOUN
ijpds-3935	16	31	[	[	X
ijpds-3935	16	32	2	2	NUM
ijpds-3935	16	33	]	]	PUNCT
ijpds-3935	16	34	.	.	PUNCT
ijpds-3935	17	1	an	an	DET
ijpds-3935	17	2	enormous	enormous	ADJ
ijpds-3935	17	3	amount	amount	NOUN
ijpds-3935	17	4	of	of	ADP
ijpds-3935	17	5	work	work	NOUN
ijpds-3935	17	6	has	have	AUX
ijpds-3935	17	7	gone	go	VERB
ijpds-3935	17	8	into	into	ADP
ijpds-3935	17	9	creating	create	VERB
ijpds-3935	17	10	sirna	sirna	PROPN
ijpds-3935	17	11	-	-	PUNCT
ijpds-3935	17	12	based	base	VERB
ijpds-3935	17	13	cancer	cancer	NOUN
ijpds-3935	17	14	medicines	medicine	NOUN
ijpds-3935	17	15	in	in	ADP
ijpds-3935	17	16	recent	recent	ADJ
ijpds-3935	17	17	years	year	NOUN
ijpds-3935	17	18	.	.	PUNCT
ijpds-3935	18	1	the	the	DET
ijpds-3935	18	2	capacity	capacity	NOUN
ijpds-3935	18	3	of	of	ADP
ijpds-3935	18	4	sirnas	sirna	NOUN
ijpds-3935	18	5	to	to	PART
ijpds-3935	18	6	specifically	specifically	ADV
ijpds-3935	18	7	target	target	VERB
ijpds-3935	18	8	oncogenes	oncogene	NOUN
ijpds-3935	18	9	offers	offer	VERB
ijpds-3935	18	10	a	a	DET
ijpds-3935	18	11	promising	promising	ADJ
ijpds-3935	18	12	strategy	strategy	NOUN
ijpds-3935	18	13	for	for	ADP
ijpds-3935	18	14	the	the	DET
ijpds-3935	18	15	creation	creation	NOUN
ijpds-3935	18	16	of	of	ADP
ijpds-3935	18	17	highly	highly	ADV
ijpds-3935	18	18	effective	effective	ADJ
ijpds-3935	18	19	cancer	cancer	NOUN
ijpds-3935	18	20	treatments	treatment	NOUN
ijpds-3935	18	21	with	with	ADP
ijpds-3935	18	22	little	little	ADJ
ijpds-3935	18	23	offtarget	offtarget	NOUN
ijpds-3935	18	24	side	side	NOUN
ijpds-3935	18	25	effects	effect	NOUN
ijpds-3935	18	26	.	.	PUNCT
ijpds-3935	19	1	moreover	moreover	ADV
ijpds-3935	19	2	,	,	PUNCT
ijpds-3935	19	3	sirnas	sirna	NOUN
ijpds-3935	19	4	have	have	VERB
ijpds-3935	19	5	the	the	DET
ijpds-3935	19	6	potential	potential	NOUN
ijpds-3935	19	7	to	to	PART
ijpds-3935	19	8	address	address	VERB
ijpds-3935	19	9	the	the	DET
ijpds-3935	19	10	drawbacks	drawback	NOUN
ijpds-3935	19	11	of	of	ADP
ijpds-3935	19	12	conventional	conventional	ADJ
ijpds-3935	19	13	cancer	cancer	NOUN
ijpds-3935	19	14	therapies	therapy	NOUN
ijpds-3935	19	15	,	,	PUNCT
ijpds-3935	19	16	such	such	ADJ
ijpds-3935	19	17	as	as	ADP
ijpds-3935	19	18	chemotherapy	chemotherapy	NOUN
ijpds-3935	19	19	medicines	medicine	NOUN
ijpds-3935	19	20	,	,	PUNCT
ijpds-3935	19	21	which	which	PRON
ijpds-3935	19	22	frequently	frequently	ADV
ijpds-3935	19	23	exhibit	exhibit	VERB
ijpds-3935	19	24	low	low	ADJ
ijpds-3935	19	25	selectivity	selectivity	NOUN
ijpds-3935	19	26	and	and	CCONJ
ijpds-3935	19	27	high	high	ADJ
ijpds-3935	19	28	levels	level	NOUN
ijpds-3935	19	29	of	of	ADP
ijpds-3935	19	30	toxicity	toxicity	NOUN
ijpds-3935	19	31	[	[	X
ijpds-3935	19	32	3	3	NUM
ijpds-3935	19	33	]	]	PUNCT
ijpds-3935	19	34	.	.	PUNCT
ijpds-3935	20	1	an	an	DET
ijpds-3935	20	2	overview	overview	NOUN
ijpds-3935	20	3	of	of	ADP
ijpds-3935	20	4	the	the	DET
ijpds-3935	20	5	present	present	ADJ
ijpds-3935	20	6	status	status	NOUN
ijpds-3935	20	7	of	of	ADP
ijpds-3935	20	8	sirna	sirna	PROPN
ijpds-3935	20	9	-	-	PUNCT
ijpds-3935	20	10	mediated	mediate	VERB
ijpds-3935	20	11	oncogene	oncogene	NOUN
ijpds-3935	20	12	silencing	silence	VERB
ijpds-3935	20	13	for	for	ADP
ijpds-3935	20	14	cancer	cancer	NOUN
ijpds-3935	20	15	therapy	therapy	NOUN
ijpds-3935	20	16	will	will	AUX
ijpds-3935	20	17	be	be	AUX
ijpds-3935	20	18	given	give	VERB
ijpds-3935	20	19	in	in	ADP
ijpds-3935	20	20	this	this	DET
ijpds-3935	20	21	thorough	thorough	ADJ
ijpds-3935	20	22	review	review	NOUN
ijpds-3935	20	23	.	.	PUNCT
ijpds-3935	21	1	the	the	DET
ijpds-3935	21	2	review	review	NOUN
ijpds-3935	21	3	will	will	AUX
ijpds-3935	21	4	go	go	VERB
ijpds-3935	21	5	over	over	ADP
ijpds-3935	21	6	the	the	DET
ijpds-3935	21	7	various	various	ADJ
ijpds-3935	21	8	sirna	sirna	PROPN
ijpds-3935	21	9	delivery	delivery	NOUN
ijpds-3935	21	10	methods	method	NOUN
ijpds-3935	21	11	,	,	PUNCT
ijpds-3935	21	12	the	the	DET
ijpds-3935	21	13	difficulties	difficulty	NOUN
ijpds-3935	21	14	faced	face	VERB
ijpds-3935	21	15	by	by	ADP
ijpds-3935	21	16	sirna	sirna	PROPN
ijpds-3935	21	17	-	-	PUNCT
ijpds-3935	21	18	based	base	VERB
ijpds-3935	21	19	therapies	therapy	NOUN
ijpds-3935	21	20	,	,	PUNCT
ijpds-3935	21	21	and	and	CCONJ
ijpds-3935	21	22	the	the	DET
ijpds-3935	21	23	development	development	NOUN
ijpds-3935	21	24	of	of	ADP
ijpds-3935	21	25	sirna	sirna	PROPN
ijpds-3935	21	26	-	-	PUNCT
ijpds-3935	21	27	based	base	VERB
ijpds-3935	21	28	cancer	cancer	NOUN
ijpds-3935	21	29	therapy	therapy	NOUN
ijpds-3935	21	30	in	in	ADP
ijpds-3935	21	31	the	the	DET
ijpds-3935	21	32	clinic	clinic	NOUN
ijpds-3935	21	33	[	[	X
ijpds-3935	21	34	4	4	NUM
ijpds-3935	21	35	]	]	PUNCT
ijpds-3935	21	36	.	.	PUNCT
ijpds-3935	22	1	future	future	ADJ
ijpds-3935	22	2	developments	development	NOUN
ijpds-3935	22	3	in	in	ADP
ijpds-3935	22	4	this	this	DET
ijpds-3935	22	5	area	area	NOUN
ijpds-3935	22	6	as	as	ADV
ijpds-3935	22	7	well	well	ADV
ijpds-3935	22	8	as	as	ADP
ijpds-3935	22	9	the	the	DET
ijpds-3935	22	10	possibilities	possibility	NOUN
ijpds-3935	22	11	of	of	ADP
ijpds-3935	22	12	sirna	sirna	PROPN
ijpds-3935	22	13	-	-	PUNCT
ijpds-3935	22	14	based	base	VERB
ijpds-3935	22	15	cancer	cancer	NOUN
ijpds-3935	22	16	therapeutics	therapeutic	NOUN
ijpds-3935	22	17	will	will	AUX
ijpds-3935	22	18	be	be	AUX
ijpds-3935	22	19	covered	cover	VERB
ijpds-3935	22	20	.	.	PUNCT
ijpds-3935	23	1	ultimately	ultimately	ADV
ijpds-3935	23	2	,	,	PUNCT
ijpds-3935	23	3	the	the	DET
ijpds-3935	23	4	goal	goal	NOUN
ijpds-3935	23	5	of	of	ADP
ijpds-3935	23	6	this	this	DET
ijpds-3935	23	7	study	study	NOUN
ijpds-3935	23	8	is	be	AUX
ijpds-3935	23	9	to	to	PART
ijpds-3935	23	10	provide	provide	VERB
ijpds-3935	23	11	a	a	DET
ijpds-3935	23	12	thorough	thorough	ADJ
ijpds-3935	23	13	grasp	grasp	NOUN
ijpds-3935	23	14	of	of	ADP
ijpds-3935	23	15	the	the	DET
ijpds-3935	23	16	status	status	NOUN
ijpds-3935	23	17	and	and	CCONJ
ijpds-3935	23	18	potential	potential	ADJ
ijpds-3935	23	19	applications	application	NOUN
ijpds-3935	23	20	of	of	ADP
ijpds-3935	23	21	sirna	sirna	PROPN
ijpds-3935	23	22	-	-	PUNCT
ijpds-3935	23	23	mediated	mediate	VERB
ijpds-3935	23	24	oncogene	oncogene	NOUN
ijpds-3935	23	25	silencing	silence	VERB
ijpds-3935	23	26	for	for	ADP
ijpds-3935	23	27	cancer	cancer	NOUN
ijpds-3935	23	28	therapy	therapy	NOUN
ijpds-3935	23	29	[	[	X
ijpds-3935	23	30	5	5	NUM
ijpds-3935	23	31	]	]	PUNCT
ijpds-3935	23	32	.	.	PUNCT
ijpds-3935	24	1	fig	fig	NOUN
ijpds-3935	24	2	no.1	no.1	NOUN
ijpds-3935	24	3	:	:	PUNCT
ijpds-3935	24	4	delivery	delivery	NOUN
ijpds-3935	24	5	systems	system	NOUN
ijpds-3935	24	6	for	for	ADP
ijpds-3935	24	7	sirna	sirna	PROPN
ijpds-3935	24	8	drug	drug	PROPN
ijpds-3935	24	9	development	development	NOUN
ijpds-3935	24	10	in	in	ADP
ijpds-3935	24	11	cancer	cancer	NOUN
ijpds-3935	24	12	therapy	therapy	NOUN
ijpds-3935	25	1	[	[	X
ijpds-3935	25	2	6	6	NUM
ijpds-3935	25	3	]	]	PUNCT
ijpds-3935	25	4	a	a	DET
ijpds-3935	25	5	mailto:ramdas21@gmail.com	mailto:ramdas21@gmail.com	NOUN
ijpds-3935	25	6	shanbhag	shanbhag	NOUN
ijpds-3935	25	7	et	et	PROPN
ijpds-3935	25	8	al	al	PROPN
ijpds-3935	25	9	.	.	PUNCT
ijpds-3935	25	10	cancer	cancer	NOUN
ijpds-3935	25	11	therapy	therapy	NOUN
ijpds-3935	25	12	:	:	PUNCT
ijpds-3935	25	13	an	an	DET
ijpds-3935	25	14	overview	overview	NOUN
ijpds-3935	25	15	of	of	ADP
ijpds-3935	25	16	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	25	17	strategies	strategy	NOUN
ijpds-3935	25	18	vol	vol	VERB
ijpds-3935	25	19	2|	2|	NUM
ijpds-3935	25	20	issue	issue	NOUN
ijpds-3935	25	21	2	2	NUM
ijpds-3935	25	22	|	|	ADV
ijpds-3935	25	23	apr	apr	ADV
ijpds-3935	25	24	–	–	PUNCT
ijpds-3935	25	25	jun	jun	PROPN
ijpds-3935	25	26	2023	2023	NUM
ijpds-3935	25	27	indian	indian	PROPN
ijpds-3935	25	28	j	j	PROPN
ijpds-3935	25	29	pharm	pharm	PROPN
ijpds-3935	25	30	drug	drug	PROPN
ijpds-3935	25	31	studies	study	NOUN
ijpds-3935	25	32	|	|	ADV
ijpds-3935	25	33	64	64	NUM
ijpds-3935	25	34	different	different	ADJ
ijpds-3935	25	35	approaches	approach	NOUN
ijpds-3935	25	36	used	use	VERB
ijpds-3935	25	37	for	for	ADP
ijpds-3935	25	38	sirna	sirna	PROPN
ijpds-3935	25	39	delivery	delivery	NOUN
ijpds-3935	25	40	for	for	ADP
ijpds-3935	25	41	cancer	cancer	NOUN
ijpds-3935	25	42	therapy	therapy	NOUN
ijpds-3935	25	43	the	the	DET
ijpds-3935	25	44	development	development	NOUN
ijpds-3935	25	45	of	of	ADP
ijpds-3935	25	46	sirna	sirna	PROPN
ijpds-3935	25	47	-	-	PUNCT
ijpds-3935	25	48	based	base	VERB
ijpds-3935	25	49	cancer	cancer	NOUN
ijpds-3935	25	50	therapeutics	therapeutic	NOUN
ijpds-3935	25	51	faces	face	VERB
ijpds-3935	25	52	significant	significant	ADJ
ijpds-3935	25	53	challenges	challenge	NOUN
ijpds-3935	25	54	in	in	ADP
ijpds-3935	25	55	the	the	DET
ijpds-3935	25	56	efficient	efficient	ADJ
ijpds-3935	25	57	delivery	delivery	NOUN
ijpds-3935	25	58	of	of	ADP
ijpds-3935	25	59	sirna	sirna	PROPN
ijpds-3935	25	60	to	to	ADP
ijpds-3935	25	61	cancer	cancer	NOUN
ijpds-3935	25	62	cells	cell	NOUN
ijpds-3935	25	63	.	.	PUNCT
ijpds-3935	26	1	delivering	deliver	VERB
ijpds-3935	26	2	sirnas	sirna	NOUN
ijpds-3935	26	3	to	to	PART
ijpds-3935	26	4	target	target	VERB
ijpds-3935	26	5	cells	cell	NOUN
ijpds-3935	26	6	can	can	AUX
ijpds-3935	26	7	be	be	AUX
ijpds-3935	26	8	difficult	difficult	ADJ
ijpds-3935	26	9	since	since	SCONJ
ijpds-3935	26	10	they	they	PRON
ijpds-3935	26	11	are	be	AUX
ijpds-3935	26	12	generally	generally	ADV
ijpds-3935	26	13	big	big	ADJ
ijpds-3935	26	14	,	,	PUNCT
ijpds-3935	26	15	negatively	negatively	ADV
ijpds-3935	26	16	charged	charge	VERB
ijpds-3935	26	17	molecules	molecule	NOUN
ijpds-3935	26	18	that	that	PRON
ijpds-3935	26	19	are	be	AUX
ijpds-3935	26	20	prone	prone	ADJ
ijpds-3935	26	21	to	to	ADP
ijpds-3935	26	22	nuclease	nuclease	ADJ
ijpds-3935	26	23	destruction	destruction	NOUN
ijpds-3935	27	1	[	[	X
ijpds-3935	27	2	5	5	NUM
ijpds-3935	27	3	]	]	PUNCT
ijpds-3935	27	4	.	.	PUNCT
ijpds-3935	28	1	biological	biological	ADJ
ijpds-3935	28	2	obstacles	obstacle	NOUN
ijpds-3935	28	3	like	like	ADP
ijpds-3935	28	4	the	the	DET
ijpds-3935	28	5	extracellular	extracellular	ADJ
ijpds-3935	28	6	matrix	matrix	NOUN
ijpds-3935	28	7	,	,	PUNCT
ijpds-3935	28	8	cellular	cellular	ADJ
ijpds-3935	28	9	membranes	membrane	NOUN
ijpds-3935	28	10	,	,	PUNCT
ijpds-3935	28	11	and	and	CCONJ
ijpds-3935	28	12	endosomal	endosomal	ADJ
ijpds-3935	28	13	compartments	compartment	NOUN
ijpds-3935	28	14	must	must	AUX
ijpds-3935	28	15	also	also	ADV
ijpds-3935	28	16	be	be	AUX
ijpds-3935	28	17	surmounted	surmount	VERB
ijpds-3935	28	18	by	by	ADP
ijpds-3935	28	19	the	the	DET
ijpds-3935	28	20	sirna	sirna	PROPN
ijpds-3935	28	21	delivery	delivery	NOUN
ijpds-3935	28	22	mechanism	mechanism	NOUN
ijpds-3935	28	23	.	.	PUNCT
ijpds-3935	29	1	to	to	PART
ijpds-3935	29	2	get	get	VERB
ijpds-3935	29	3	over	over	ADP
ijpds-3935	29	4	these	these	DET
ijpds-3935	29	5	obstacles	obstacle	NOUN
ijpds-3935	29	6	and	and	CCONJ
ijpds-3935	29	7	make	make	VERB
ijpds-3935	29	8	sirna	sirna	PROPN
ijpds-3935	29	9	distribution	distribution	NOUN
ijpds-3935	29	10	to	to	ADP
ijpds-3935	29	11	cancer	cancer	NOUN
ijpds-3935	29	12	cells	cell	NOUN
ijpds-3935	29	13	easier	easy	ADJ
ijpds-3935	29	14	,	,	PUNCT
ijpds-3935	29	15	a	a	DET
ijpds-3935	29	16	number	number	NOUN
ijpds-3935	29	17	of	of	ADP
ijpds-3935	29	18	strategies	strategy	NOUN
ijpds-3935	29	19	have	have	AUX
ijpds-3935	29	20	been	be	AUX
ijpds-3935	29	21	devised	devise	VERB
ijpds-3935	29	22	[	[	PUNCT
ijpds-3935	29	23	7	7	NUM
ijpds-3935	29	24	]	]	PUNCT
ijpds-3935	29	25	.	.	PUNCT
ijpds-3935	30	1	lipid	lipid	NOUN
ijpds-3935	30	2	-	-	PUNCT
ijpds-3935	30	3	based	base	VERB
ijpds-3935	30	4	delivery	delivery	NOUN
ijpds-3935	30	5	systems	system	NOUN
ijpds-3935	30	6	one	one	NUM
ijpds-3935	30	7	of	of	ADP
ijpds-3935	30	8	the	the	DET
ijpds-3935	30	9	most	most	ADV
ijpds-3935	30	10	widely	widely	ADV
ijpds-3935	30	11	used	use	VERB
ijpds-3935	30	12	methods	method	NOUN
ijpds-3935	30	13	for	for	ADP
ijpds-3935	30	14	sirna	sirna	PROPN
ijpds-3935	30	15	distribution	distribution	NOUN
ijpds-3935	30	16	is	be	AUX
ijpds-3935	30	17	lipid	lipid	NOUN
ijpds-3935	30	18	-	-	PUNCT
ijpds-3935	30	19	based	base	VERB
ijpds-3935	30	20	delivery	delivery	NOUN
ijpds-3935	30	21	systems	system	NOUN
ijpds-3935	30	22	.	.	PUNCT
ijpds-3935	31	1	a	a	DET
ijpds-3935	31	2	hydrophobic	hydrophobic	NOUN
ijpds-3935	31	3	core	core	NOUN
ijpds-3935	31	4	that	that	PRON
ijpds-3935	31	5	can	can	AUX
ijpds-3935	31	6	enclose	enclose	VERB
ijpds-3935	31	7	sirnas	sirna	NOUN
ijpds-3935	31	8	is	be	AUX
ijpds-3935	31	9	often	often	ADV
ijpds-3935	31	10	surrounded	surround	VERB
ijpds-3935	31	11	by	by	ADP
ijpds-3935	31	12	a	a	DET
ijpds-3935	31	13	lipid	lipid	NOUN
ijpds-3935	31	14	bilayer	bilayer	NOUN
ijpds-3935	31	15	in	in	ADP
ijpds-3935	31	16	lipid	lipid	ADJ
ijpds-3935	31	17	nanoparticles	nanoparticle	NOUN
ijpds-3935	31	18	[	[	X
ijpds-3935	31	19	8	8	NUM
ijpds-3935	31	20	]	]	PUNCT
ijpds-3935	31	21	.	.	PUNCT
ijpds-3935	32	1	these	these	DET
ijpds-3935	32	2	nanoparticles	nanoparticle	NOUN
ijpds-3935	32	3	can	can	AUX
ijpds-3935	32	4	passively	passively	ADV
ijpds-3935	32	5	gather	gather	VERB
ijpds-3935	32	6	in	in	ADP
ijpds-3935	32	7	tumor	tumor	NOUN
ijpds-3935	32	8	tissues	tissue	NOUN
ijpds-3935	32	9	due	due	ADP
ijpds-3935	32	10	to	to	ADP
ijpds-3935	32	11	the	the	DET
ijpds-3935	32	12	improved	improved	ADJ
ijpds-3935	32	13	permeability	permeability	NOUN
ijpds-3935	32	14	and	and	CCONJ
ijpds-3935	32	15	retention	retention	NOUN
ijpds-3935	32	16	impact	impact	NOUN
ijpds-3935	32	17	because	because	SCONJ
ijpds-3935	32	18	their	their	PRON
ijpds-3935	32	19	size	size	NOUN
ijpds-3935	32	20	ranges	range	VERB
ijpds-3935	32	21	from	from	ADP
ijpds-3935	32	22	20	20	NUM
ijpds-3935	32	23	to	to	PART
ijpds-3935	32	24	100	100	NUM
ijpds-3935	32	25	nm	nm	NOUN
ijpds-3935	32	26	(	(	PUNCT
ijpds-3935	32	27	epr	epr	PROPN
ijpds-3935	32	28	)	)	PUNCT
ijpds-3935	32	29	.	.	PUNCT
ijpds-3935	33	1	by	by	ADP
ijpds-3935	33	2	integrating	integrate	VERB
ijpds-3935	33	3	targeting	target	VERB
ijpds-3935	33	4	moieties	moiety	NOUN
ijpds-3935	33	5	like	like	ADP
ijpds-3935	33	6	antibodies	antibody	NOUN
ijpds-3935	33	7	,	,	PUNCT
ijpds-3935	33	8	peptides	peptide	NOUN
ijpds-3935	33	9	,	,	PUNCT
ijpds-3935	33	10	or	or	CCONJ
ijpds-3935	33	11	aptamers	aptamer	NOUN
ijpds-3935	33	12	,	,	PUNCT
ijpds-3935	33	13	lipid	lipid	NOUN
ijpds-3935	33	14	-	-	PUNCT
ijpds-3935	33	15	based	base	VERB
ijpds-3935	33	16	delivery	delivery	NOUN
ijpds-3935	33	17	systems	system	NOUN
ijpds-3935	33	18	can	can	AUX
ijpds-3935	33	19	also	also	ADV
ijpds-3935	33	20	be	be	AUX
ijpds-3935	33	21	designed	design	VERB
ijpds-3935	33	22	to	to	PART
ijpds-3935	33	23	target	target	VERB
ijpds-3935	33	24	particular	particular	ADJ
ijpds-3935	33	25	cell	cell	NOUN
ijpds-3935	33	26	types	type	NOUN
ijpds-3935	34	1	[	[	X
ijpds-3935	34	2	9	9	NUM
ijpds-3935	34	3	]	]	PUNCT
ijpds-3935	34	4	.	.	PUNCT
ijpds-3935	34	5	polymer	polymer	NOUN
ijpds-3935	34	6	-	-	PUNCT
ijpds-3935	34	7	based	base	VERB
ijpds-3935	34	8	delivery	delivery	NOUN
ijpds-3935	34	9	systems	system	NOUN
ijpds-3935	34	10	are	be	AUX
ijpds-3935	34	11	biodegradable	biodegradable	ADJ
ijpds-3935	34	12	polymers	polymer	NOUN
ijpds-3935	34	13	used	use	VERB
ijpds-3935	34	14	to	to	PART
ijpds-3935	34	15	encase	encase	VERB
ijpds-3935	34	16	sirnas	sirna	NOUN
ijpds-3935	34	17	in	in	ADP
ijpds-3935	34	18	polymer	polymer	NOUN
ijpds-3935	34	19	-	-	PUNCT
ijpds-3935	34	20	based	base	VERB
ijpds-3935	34	21	delivery	delivery	NOUN
ijpds-3935	34	22	systems	system	NOUN
ijpds-3935	34	23	.	.	PUNCT
ijpds-3935	35	1	these	these	DET
ijpds-3935	35	2	systems	system	NOUN
ijpds-3935	35	3	can	can	AUX
ijpds-3935	35	4	be	be	AUX
ijpds-3935	35	5	made	make	VERB
ijpds-3935	35	6	to	to	PART
ijpds-3935	35	7	have	have	VERB
ijpds-3935	35	8	different	different	ADJ
ijpds-3935	35	9	characteristics	characteristic	NOUN
ijpds-3935	35	10	,	,	PUNCT
ijpds-3935	35	11	such	such	ADJ
ijpds-3935	35	12	as	as	ADP
ijpds-3935	35	13	size	size	NOUN
ijpds-3935	35	14	,	,	PUNCT
ijpds-3935	35	15	charge	charge	NOUN
ijpds-3935	35	16	,	,	PUNCT
ijpds-3935	35	17	and	and	CCONJ
ijpds-3935	35	18	hydrophobicity	hydrophobicity	NOUN
ijpds-3935	35	19	,	,	PUNCT
ijpds-3935	35	20	which	which	PRON
ijpds-3935	35	21	can	can	AUX
ijpds-3935	35	22	influence	influence	VERB
ijpds-3935	35	23	how	how	SCONJ
ijpds-3935	35	24	they	they	PRON
ijpds-3935	35	25	are	be	AUX
ijpds-3935	35	26	taken	take	VERB
ijpds-3935	35	27	up	up	ADP
ijpds-3935	35	28	by	by	ADP
ijpds-3935	35	29	cells	cell	NOUN
ijpds-3935	35	30	and	and	CCONJ
ijpds-3935	35	31	transported	transport	VERB
ijpds-3935	35	32	within	within	ADP
ijpds-3935	35	33	them	they	PRON
ijpds-3935	35	34	.	.	PUNCT
ijpds-3935	36	1	by	by	ADP
ijpds-3935	36	2	adding	add	VERB
ijpds-3935	36	3	targeting	target	VERB
ijpds-3935	36	4	moieties	moiety	NOUN
ijpds-3935	36	5	,	,	PUNCT
ijpds-3935	36	6	polymer	polymer	NOUN
ijpds-3935	36	7	-	-	PUNCT
ijpds-3935	36	8	based	base	VERB
ijpds-3935	36	9	systems	system	NOUN
ijpds-3935	36	10	can	can	AUX
ijpds-3935	36	11	also	also	ADV
ijpds-3935	36	12	be	be	AUX
ijpds-3935	36	13	created	create	VERB
ijpds-3935	36	14	to	to	PART
ijpds-3935	36	15	target	target	VERB
ijpds-3935	36	16	particular	particular	ADJ
ijpds-3935	36	17	cell	cell	NOUN
ijpds-3935	36	18	types	type	NOUN
ijpds-3935	37	1	[	[	X
ijpds-3935	37	2	10	10	NUM
ijpds-3935	37	3	]	]	PUNCT
ijpds-3935	37	4	.	.	PUNCT
ijpds-3935	38	1	delivery	delivery	NOUN
ijpds-3935	38	2	methods	method	NOUN
ijpds-3935	38	3	based	base	VERB
ijpds-3935	38	4	on	on	ADP
ijpds-3935	38	5	inorganic	inorganic	ADJ
ijpds-3935	38	6	nanoparticles	nanoparticle	NOUN
ijpds-3935	38	7	for	for	ADP
ijpds-3935	38	8	the	the	DET
ijpds-3935	38	9	transport	transport	NOUN
ijpds-3935	38	10	of	of	ADP
ijpds-3935	38	11	sirna	sirna	PROPN
ijpds-3935	38	12	,	,	PUNCT
ijpds-3935	38	13	and	and	CCONJ
ijpds-3935	38	14	inorganic	inorganic	ADJ
ijpds-3935	38	15	nanoparticles	nanoparticle	NOUN
ijpds-3935	38	16	like	like	ADP
ijpds-3935	38	17	gold	gold	NOUN
ijpds-3935	38	18	,	,	PUNCT
ijpds-3935	38	19	silica	silica	NOUN
ijpds-3935	38	20	,	,	PUNCT
ijpds-3935	38	21	and	and	CCONJ
ijpds-3935	38	22	iron	iron	NOUN
ijpds-3935	38	23	oxide	oxide	NOUN
ijpds-3935	38	24	have	have	AUX
ijpds-3935	38	25	been	be	AUX
ijpds-3935	38	26	researched	research	VERB
ijpds-3935	38	27	.	.	PUNCT
ijpds-3935	39	1	to	to	PART
ijpds-3935	39	2	make	make	VERB
ijpds-3935	39	3	these	these	DET
ijpds-3935	39	4	particles	particle	NOUN
ijpds-3935	39	5	easier	easy	ADJ
ijpds-3935	39	6	for	for	SCONJ
ijpds-3935	39	7	cancer	cancer	NOUN
ijpds-3935	39	8	cells	cell	NOUN
ijpds-3935	39	9	to	to	PART
ijpds-3935	39	10	absorb	absorb	VERB
ijpds-3935	39	11	,	,	PUNCT
ijpds-3935	39	12	they	they	PRON
ijpds-3935	39	13	can	can	AUX
ijpds-3935	39	14	be	be	AUX
ijpds-3935	39	15	functionalized	functionalize	VERB
ijpds-3935	39	16	with	with	ADP
ijpds-3935	39	17	sirnas	sirna	NOUN
ijpds-3935	39	18	and/or	and/or	CCONJ
ijpds-3935	39	19	target	target	VERB
ijpds-3935	39	20	molecules	molecule	NOUN
ijpds-3935	39	21	[	[	X
ijpds-3935	39	22	11	11	NUM
ijpds-3935	39	23	]	]	PUNCT
ijpds-3935	39	24	.	.	PUNCT
ijpds-3935	40	1	the	the	DET
ijpds-3935	40	2	special	special	ADJ
ijpds-3935	40	3	physicochemical	physicochemical	ADJ
ijpds-3935	40	4	characteristics	characteristic	NOUN
ijpds-3935	40	5	of	of	ADP
ijpds-3935	40	6	inorganic	inorganic	ADJ
ijpds-3935	40	7	nanoparticles	nanoparticle	NOUN
ijpds-3935	40	8	can	can	AUX
ijpds-3935	40	9	be	be	AUX
ijpds-3935	40	10	used	use	VERB
ijpds-3935	40	11	to	to	PART
ijpds-3935	40	12	promote	promote	VERB
ijpds-3935	40	13	cellular	cellular	ADJ
ijpds-3935	40	14	absorption	absorption	NOUN
ijpds-3935	40	15	,	,	PUNCT
ijpds-3935	40	16	endosomal	endosomal	ADJ
ijpds-3935	40	17	escape	escape	NOUN
ijpds-3935	40	18	,	,	PUNCT
ijpds-3935	40	19	and	and	CCONJ
ijpds-3935	40	20	gene	gene	NOUN
ijpds-3935	40	21	silencing	silence	VERB
ijpds-3935	40	22	[	[	X
ijpds-3935	40	23	12	12	NUM
ijpds-3935	40	24	]	]	PUNCT
ijpds-3935	40	25	.	.	PUNCT
ijpds-3935	41	1	viral	viral	ADJ
ijpds-3935	41	2	vectors	vector	NOUN
ijpds-3935	41	3	have	have	AUX
ijpds-3935	41	4	been	be	AUX
ijpds-3935	41	5	used	use	VERB
ijpds-3935	41	6	to	to	PART
ijpds-3935	41	7	distribute	distribute	VERB
ijpds-3935	41	8	sirna	sirna	PROPN
ijpds-3935	41	9	because	because	SCONJ
ijpds-3935	41	10	they	they	PRON
ijpds-3935	41	11	are	be	AUX
ijpds-3935	41	12	particularly	particularly	ADV
ijpds-3935	41	13	effective	effective	ADJ
ijpds-3935	41	14	in	in	ADP
ijpds-3935	41	15	delivering	deliver	VERB
ijpds-3935	41	16	genes	gene	NOUN
ijpds-3935	41	17	to	to	ADP
ijpds-3935	41	18	cells	cell	NOUN
ijpds-3935	41	19	.	.	PUNCT
ijpds-3935	42	1	however	however	ADV
ijpds-3935	42	2	,	,	PUNCT
ijpds-3935	42	3	because	because	SCONJ
ijpds-3935	42	4	of	of	ADP
ijpds-3935	42	5	safety	safety	NOUN
ijpds-3935	42	6	issues	issue	NOUN
ijpds-3935	42	7	such	such	ADJ
ijpds-3935	42	8	as	as	ADP
ijpds-3935	42	9	immunogenicity	immunogenicity	NOUN
ijpds-3935	42	10	and	and	CCONJ
ijpds-3935	42	11	mutagenicity	mutagenicity	NOUN
ijpds-3935	42	12	,	,	PUNCT
ijpds-3935	42	13	their	their	PRON
ijpds-3935	42	14	use	use	NOUN
ijpds-3935	42	15	is	be	AUX
ijpds-3935	42	16	restricted	restrict	VERB
ijpds-3935	42	17	.	.	PUNCT
ijpds-3935	43	1	usually	usually	ADV
ijpds-3935	43	2	,	,	PUNCT
ijpds-3935	43	3	viral	viral	ADJ
ijpds-3935	43	4	vectors	vector	NOUN
ijpds-3935	43	5	are	be	AUX
ijpds-3935	43	6	altered	alter	VERB
ijpds-3935	43	7	to	to	PART
ijpds-3935	43	8	lose	lose	VERB
ijpds-3935	43	9	their	their	PRON
ijpds-3935	43	10	pathogenicity	pathogenicity	NOUN
ijpds-3935	43	11	and	and	CCONJ
ijpds-3935	43	12	designed	design	VERB
ijpds-3935	43	13	to	to	PART
ijpds-3935	43	14	express	express	VERB
ijpds-3935	43	15	sirnas	sirna	NOUN
ijpds-3935	43	16	for	for	ADP
ijpds-3935	43	17	certain	certain	ADJ
ijpds-3935	43	18	targets	target	NOUN
ijpds-3935	43	19	[	[	X
ijpds-3935	43	20	13	13	NUM
ijpds-3935	43	21	]	]	PUNCT
ijpds-3935	43	22	.	.	PUNCT
ijpds-3935	44	1	cell	cell	NOUN
ijpds-3935	44	2	-	-	PUNCT
ijpds-3935	44	3	penetrating	penetrate	VERB
ijpds-3935	44	4	peptides	peptide	NOUN
ijpds-3935	44	5	(	(	PUNCT
ijpds-3935	44	6	cpps	cpp	NOUN
ijpds-3935	44	7	)	)	PUNCT
ijpds-3935	44	8	are	be	AUX
ijpds-3935	44	9	short	short	ADJ
ijpds-3935	44	10	peptides	peptide	NOUN
ijpds-3935	44	11	that	that	PRON
ijpds-3935	44	12	can	can	AUX
ijpds-3935	44	13	penetrate	penetrate	VERB
ijpds-3935	44	14	cell	cell	NOUN
ijpds-3935	44	15	membranes	membrane	NOUN
ijpds-3935	44	16	and	and	CCONJ
ijpds-3935	44	17	facilitate	facilitate	VERB
ijpds-3935	44	18	the	the	DET
ijpds-3935	44	19	delivery	delivery	NOUN
ijpds-3935	44	20	of	of	ADP
ijpds-3935	44	21	sirnas	sirna	NOUN
ijpds-3935	44	22	into	into	ADP
ijpds-3935	44	23	cells	cell	NOUN
ijpds-3935	44	24	.	.	PUNCT
ijpds-3935	45	1	cpps	cpps	PROPN
ijpds-3935	45	2	can	can	AUX
ijpds-3935	45	3	be	be	AUX
ijpds-3935	45	4	fused	fuse	VERB
ijpds-3935	45	5	to	to	ADP
ijpds-3935	45	6	sirnas	sirna	NOUN
ijpds-3935	45	7	to	to	PART
ijpds-3935	45	8	enhance	enhance	VERB
ijpds-3935	45	9	their	their	PRON
ijpds-3935	45	10	cellular	cellular	ADJ
ijpds-3935	45	11	uptake	uptake	NOUN
ijpds-3935	45	12	and	and	CCONJ
ijpds-3935	45	13	endosomal	endosomal	ADJ
ijpds-3935	45	14	escape	escape	NOUN
ijpds-3935	45	15	.	.	PUNCT
ijpds-3935	46	1	however	however	ADV
ijpds-3935	46	2	,	,	PUNCT
ijpds-3935	46	3	the	the	DET
ijpds-3935	46	4	delivery	delivery	NOUN
ijpds-3935	46	5	efficiency	efficiency	NOUN
ijpds-3935	46	6	of	of	ADP
ijpds-3935	46	7	cpps	cpps	NOUN
ijpds-3935	46	8	is	be	AUX
ijpds-3935	46	9	often	often	ADV
ijpds-3935	46	10	low	low	ADJ
ijpds-3935	46	11	and	and	CCONJ
ijpds-3935	46	12	is	be	AUX
ijpds-3935	46	13	dependent	dependent	ADJ
ijpds-3935	46	14	on	on	ADP
ijpds-3935	46	15	the	the	DET
ijpds-3935	46	16	type	type	NOUN
ijpds-3935	46	17	of	of	ADP
ijpds-3935	46	18	cpp	cpp	NOUN
ijpds-3935	46	19	used	use	VERB
ijpds-3935	46	20	[	[	X
ijpds-3935	46	21	14	14	NUM
ijpds-3935	46	22	]	]	PUNCT
ijpds-3935	46	23	.	.	PUNCT
ijpds-3935	47	1	overall	overall	ADV
ijpds-3935	47	2	,	,	PUNCT
ijpds-3935	47	3	each	each	DET
ijpds-3935	47	4	delivery	delivery	NOUN
ijpds-3935	47	5	system	system	NOUN
ijpds-3935	47	6	has	have	VERB
ijpds-3935	47	7	its	its	PRON
ijpds-3935	47	8	advantages	advantage	NOUN
ijpds-3935	47	9	and	and	CCONJ
ijpds-3935	47	10	limitations	limitation	NOUN
ijpds-3935	47	11	,	,	PUNCT
ijpds-3935	47	12	and	and	CCONJ
ijpds-3935	47	13	the	the	DET
ijpds-3935	47	14	choice	choice	NOUN
ijpds-3935	47	15	of	of	ADP
ijpds-3935	47	16	delivery	delivery	NOUN
ijpds-3935	47	17	system	system	NOUN
ijpds-3935	47	18	will	will	AUX
ijpds-3935	47	19	depend	depend	VERB
ijpds-3935	47	20	on	on	ADP
ijpds-3935	47	21	the	the	DET
ijpds-3935	47	22	specific	specific	ADJ
ijpds-3935	47	23	application	application	NOUN
ijpds-3935	47	24	and	and	CCONJ
ijpds-3935	47	25	target	target	NOUN
ijpds-3935	47	26	.	.	PUNCT
ijpds-3935	48	1	to	to	PART
ijpds-3935	48	2	overcome	overcome	VERB
ijpds-3935	48	3	the	the	DET
ijpds-3935	48	4	challenges	challenge	NOUN
ijpds-3935	48	5	associated	associate	VERB
ijpds-3935	48	6	with	with	ADP
ijpds-3935	48	7	sirna	sirna	PROPN
ijpds-3935	48	8	delivery	delivery	NOUN
ijpds-3935	48	9	,	,	PUNCT
ijpds-3935	48	10	researchers	researcher	NOUN
ijpds-3935	48	11	are	be	AUX
ijpds-3935	48	12	continuing	continue	VERB
ijpds-3935	48	13	to	to	PART
ijpds-3935	48	14	develop	develop	VERB
ijpds-3935	48	15	new	new	ADJ
ijpds-3935	48	16	and	and	CCONJ
ijpds-3935	48	17	innovative	innovative	ADJ
ijpds-3935	48	18	delivery	delivery	NOUN
ijpds-3935	48	19	strategies	strategy	NOUN
ijpds-3935	48	20	for	for	ADP
ijpds-3935	48	21	sirna	sirna	PROPN
ijpds-3935	48	22	-	-	PUNCT
ijpds-3935	48	23	based	base	VERB
ijpds-3935	48	24	cancer	cancer	NOUN
ijpds-3935	48	25	therapies	therapy	NOUN
ijpds-3935	48	26	.	.	PUNCT
ijpds-3935	49	1	fig	fig	PROPN
ijpds-3935	49	2	no.2	no.2	PROPN
ijpds-3935	49	3	:	:	PUNCT
ijpds-3935	50	1	different	different	ADJ
ijpds-3935	50	2	approaches	approach	NOUN
ijpds-3935	50	3	used	use	VERB
ijpds-3935	50	4	for	for	ADP
ijpds-3935	50	5	sirna	sirna	PROPN
ijpds-3935	50	6	delivery	delivery	NOUN
ijpds-3935	50	7	for	for	ADP
ijpds-3935	50	8	cancer	cancer	NOUN
ijpds-3935	50	9	therapy	therapy	NOUN
ijpds-3935	50	10	[	[	X
ijpds-3935	50	11	15	15	NUM
ijpds-3935	50	12	]	]	PUNCT
ijpds-3935	50	13	challenges	challenge	NOUN
ijpds-3935	50	14	associated	associate	VERB
ijpds-3935	50	15	with	with	ADP
ijpds-3935	50	16	sirna	sirna	PROPN
ijpds-3935	50	17	-	-	PUNCT
ijpds-3935	50	18	based	base	VERB
ijpds-3935	50	19	therapies	therapy	NOUN
ijpds-3935	50	20	while	while	SCONJ
ijpds-3935	50	21	sirna	sirna	PROPN
ijpds-3935	50	22	-	-	PUNCT
ijpds-3935	50	23	based	base	VERB
ijpds-3935	50	24	therapies	therapy	NOUN
ijpds-3935	50	25	have	have	AUX
ijpds-3935	50	26	shown	show	VERB
ijpds-3935	50	27	great	great	ADJ
ijpds-3935	50	28	promise	promise	NOUN
ijpds-3935	50	29	in	in	ADP
ijpds-3935	50	30	preclinical	preclinical	ADJ
ijpds-3935	50	31	studies	study	NOUN
ijpds-3935	50	32	and	and	CCONJ
ijpds-3935	50	33	have	have	AUX
ijpds-3935	50	34	advanced	advance	VERB
ijpds-3935	50	35	to	to	ADP
ijpds-3935	50	36	clinical	clinical	ADJ
ijpds-3935	50	37	trials	trial	NOUN
ijpds-3935	50	38	,	,	PUNCT
ijpds-3935	50	39	there	there	PRON
ijpds-3935	50	40	are	be	VERB
ijpds-3935	50	41	still	still	ADV
ijpds-3935	50	42	several	several	ADJ
ijpds-3935	50	43	challenges	challenge	NOUN
ijpds-3935	50	44	that	that	PRON
ijpds-3935	50	45	need	need	VERB
ijpds-3935	50	46	to	to	PART
ijpds-3935	50	47	be	be	AUX
ijpds-3935	50	48	overcome	overcome	VERB
ijpds-3935	50	49	to	to	PART
ijpds-3935	50	50	ensure	ensure	VERB
ijpds-3935	50	51	their	their	PRON
ijpds-3935	50	52	clinical	clinical	ADJ
ijpds-3935	50	53	success	success	NOUN
ijpds-3935	50	54	.	.	PUNCT
ijpds-3935	51	1	as	as	SCONJ
ijpds-3935	51	2	was	be	AUX
ijpds-3935	51	3	already	already	ADV
ijpds-3935	51	4	indicated	indicate	VERB
ijpds-3935	51	5	,	,	PUNCT
ijpds-3935	51	6	one	one	NUM
ijpds-3935	51	7	of	of	ADP
ijpds-3935	51	8	the	the	DET
ijpds-3935	51	9	main	main	ADJ
ijpds-3935	51	10	difficulties	difficulty	NOUN
ijpds-3935	51	11	with	with	ADP
ijpds-3935	51	12	sirna	sirna	PROPN
ijpds-3935	51	13	-	-	PUNCT
ijpds-3935	51	14	based	base	VERB
ijpds-3935	51	15	therapeutics	therapeutic	NOUN
ijpds-3935	51	16	is	be	AUX
ijpds-3935	51	17	getting	get	VERB
ijpds-3935	51	18	sirnas	sirna	NOUN
ijpds-3935	51	19	into	into	ADP
ijpds-3935	51	20	the	the	DET
ijpds-3935	51	21	target	target	NOUN
ijpds-3935	51	22	cells	cell	NOUN
ijpds-3935	51	23	.	.	PUNCT
ijpds-3935	52	1	it	it	PRON
ijpds-3935	52	2	is	be	AUX
ijpds-3935	52	3	difficult	difficult	ADJ
ijpds-3935	52	4	to	to	PART
ijpds-3935	52	5	deliver	deliver	VERB
ijpds-3935	52	6	sirnas	sirna	NOUN
ijpds-3935	52	7	because	because	SCONJ
ijpds-3935	52	8	they	they	PRON
ijpds-3935	52	9	are	be	AUX
ijpds-3935	52	10	big	big	ADJ
ijpds-3935	52	11	,	,	PUNCT
ijpds-3935	52	12	negatively	negatively	ADV
ijpds-3935	52	13	charged	charge	VERB
ijpds-3935	52	14	molecules	molecule	NOUN
ijpds-3935	52	15	that	that	PRON
ijpds-3935	52	16	are	be	AUX
ijpds-3935	52	17	vulnerable	vulnerable	ADJ
ijpds-3935	52	18	to	to	ADP
ijpds-3935	52	19	nuclease	nuclease	NOUN
ijpds-3935	52	20	destruction	destruction	NOUN
ijpds-3935	52	21	.	.	PUNCT
ijpds-3935	53	1	a	a	DET
ijpds-3935	53	2	delivery	delivery	NOUN
ijpds-3935	53	3	mechanism	mechanism	NOUN
ijpds-3935	53	4	that	that	PRON
ijpds-3935	53	5	can	can	AUX
ijpds-3935	53	6	shield	shield	VERB
ijpds-3935	53	7	sirnas	sirna	NOUN
ijpds-3935	53	8	from	from	ADP
ijpds-3935	53	9	deterioration	deterioration	NOUN
ijpds-3935	53	10	,	,	PUNCT
ijpds-3935	53	11	promote	promote	VERB
ijpds-3935	53	12	their	their	PRON
ijpds-3935	53	13	cellular	cellular	ADJ
ijpds-3935	53	14	uptake	uptake	NOUN
ijpds-3935	53	15	,	,	PUNCT
ijpds-3935	53	16	and	and	CCONJ
ijpds-3935	53	17	guarantee	guarantee	VERB
ijpds-3935	53	18	their	their	PRON
ijpds-3935	53	19	intracellular	intracellular	ADJ
ijpds-3935	53	20	trafficking	trafficking	NOUN
ijpds-3935	53	21	is	be	AUX
ijpds-3935	53	22	necessary	necessary	ADJ
ijpds-3935	53	23	for	for	ADP
ijpds-3935	53	24	effective	effective	ADJ
ijpds-3935	53	25	sirna	sirna	PROPN
ijpds-3935	53	26	delivery	delivery	NOUN
ijpds-3935	54	1	[	[	X
ijpds-3935	54	2	16	16	NUM
ijpds-3935	54	3	]	]	PUNCT
ijpds-3935	54	4	.	.	PUNCT
ijpds-3935	55	1	although	although	SCONJ
ijpds-3935	55	2	sirnas	sirna	NOUN
ijpds-3935	55	3	are	be	AUX
ijpds-3935	55	4	made	make	VERB
ijpds-3935	55	5	to	to	PART
ijpds-3935	55	6	target	target	VERB
ijpds-3935	55	7	particular	particular	ADJ
ijpds-3935	55	8	genes	gene	NOUN
ijpds-3935	55	9	,	,	PUNCT
ijpds-3935	55	10	they	they	PRON
ijpds-3935	55	11	can	can	AUX
ijpds-3935	55	12	potentially	potentially	ADV
ijpds-3935	55	13	have	have	VERB
ijpds-3935	55	14	unwanted	unwanted	ADJ
ijpds-3935	55	15	side	side	NOUN
ijpds-3935	55	16	effects	effect	NOUN
ijpds-3935	55	17	.	.	PUNCT
ijpds-3935	56	1	when	when	SCONJ
ijpds-3935	56	2	sirnas	sirna	NOUN
ijpds-3935	56	3	bind	bind	VERB
ijpds-3935	56	4	to	to	ADP
ijpds-3935	56	5	undesired	undesired	ADJ
ijpds-3935	56	6	mrna	mrna	NOUN
ijpds-3935	56	7	targets	target	NOUN
ijpds-3935	56	8	that	that	PRON
ijpds-3935	56	9	shanbhag	shanbhag	NOUN
ijpds-3935	56	10	et	et	PROPN
ijpds-3935	56	11	al	al	PROPN
ijpds-3935	56	12	.	.	PUNCT
ijpds-3935	57	1	cancer	cancer	NOUN
ijpds-3935	57	2	therapy	therapy	NOUN
ijpds-3935	57	3	:	:	PUNCT
ijpds-3935	57	4	an	an	DET
ijpds-3935	57	5	overview	overview	NOUN
ijpds-3935	57	6	of	of	ADP
ijpds-3935	57	7	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	57	8	strategies	strategy	NOUN
ijpds-3935	57	9	vol	vol	VERB
ijpds-3935	57	10	2|	2|	NUM
ijpds-3935	57	11	issue	issue	NOUN
ijpds-3935	57	12	2	2	NUM
ijpds-3935	57	13	|	|	ADV
ijpds-3935	57	14	apr	apr	ADV
ijpds-3935	57	15	–	–	PUNCT
ijpds-3935	57	16	jun	jun	PROPN
ijpds-3935	57	17	2023	2023	NUM
ijpds-3935	57	18	indian	indian	PROPN
ijpds-3935	57	19	j	j	PROPN
ijpds-3935	57	20	pharm	pharm	PROPN
ijpds-3935	57	21	drug	drug	PROPN
ijpds-3935	57	22	studies	study	NOUN
ijpds-3935	57	23	|	|	ADV
ijpds-3935	57	24	65	65	NUM
ijpds-3935	57	25	have	have	VERB
ijpds-3935	57	26	partial	partial	ADJ
ijpds-3935	57	27	sequence	sequence	NOUN
ijpds-3935	57	28	complementarity	complementarity	NOUN
ijpds-3935	57	29	to	to	ADP
ijpds-3935	57	30	the	the	DET
ijpds-3935	57	31	sirna	sirna	PROPN
ijpds-3935	57	32	,	,	PUNCT
ijpds-3935	57	33	off	off	ADP
ijpds-3935	57	34	-	-	PUNCT
ijpds-3935	57	35	target	target	NOUN
ijpds-3935	57	36	effects	effect	NOUN
ijpds-3935	57	37	may	may	AUX
ijpds-3935	57	38	result	result	VERB
ijpds-3935	57	39	.	.	PUNCT
ijpds-3935	58	1	unwanted	unwanted	ADJ
ijpds-3935	58	2	side	side	NOUN
ijpds-3935	58	3	effects	effect	NOUN
ijpds-3935	58	4	may	may	AUX
ijpds-3935	58	5	happen	happen	VERB
ijpds-3935	58	6	if	if	SCONJ
ijpds-3935	58	7	undesired	undesired	ADJ
ijpds-3935	58	8	genes	gene	NOUN
ijpds-3935	58	9	are	be	AUX
ijpds-3935	58	10	silenced	silence	VERB
ijpds-3935	58	11	as	as	ADP
ijpds-3935	58	12	a	a	DET
ijpds-3935	58	13	result	result	NOUN
ijpds-3935	58	14	of	of	ADP
ijpds-3935	58	15	this	this	PRON
ijpds-3935	58	16	[	[	X
ijpds-3935	58	17	17	17	NUM
ijpds-3935	58	18	]	]	PUNCT
ijpds-3935	58	19	.	.	PUNCT
ijpds-3935	59	1	sirnas	sirna	NOUN
ijpds-3935	59	2	have	have	VERB
ijpds-3935	59	3	the	the	DET
ijpds-3935	59	4	ability	ability	NOUN
ijpds-3935	59	5	to	to	PART
ijpds-3935	59	6	elicit	elicit	VERB
ijpds-3935	59	7	an	an	DET
ijpds-3935	59	8	immune	immune	ADJ
ijpds-3935	59	9	response	response	NOUN
ijpds-3935	59	10	,	,	PUNCT
ijpds-3935	59	11	which	which	PRON
ijpds-3935	59	12	can	can	AUX
ijpds-3935	59	13	result	result	VERB
ijpds-3935	59	14	in	in	ADP
ijpds-3935	59	15	the	the	DET
ijpds-3935	59	16	release	release	NOUN
ijpds-3935	59	17	of	of	ADP
ijpds-3935	59	18	cytokines	cytokine	NOUN
ijpds-3935	59	19	and	and	CCONJ
ijpds-3935	59	20	chemokines	chemokine	NOUN
ijpds-3935	59	21	that	that	PRON
ijpds-3935	59	22	can	can	AUX
ijpds-3935	59	23	cause	cause	VERB
ijpds-3935	59	24	cytotoxicity	cytotoxicity	NOUN
ijpds-3935	59	25	and	and	CCONJ
ijpds-3935	59	26	inflammation	inflammation	NOUN
ijpds-3935	59	27	.	.	PUNCT
ijpds-3935	60	1	although	although	SCONJ
ijpds-3935	60	2	the	the	DET
ijpds-3935	60	3	immune	immune	ADJ
ijpds-3935	60	4	system	system	NOUN
ijpds-3935	60	5	might	might	AUX
ijpds-3935	60	6	become	become	VERB
ijpds-3935	60	7	adapted	adapt	VERB
ijpds-3935	60	8	to	to	ADP
ijpds-3935	60	9	the	the	DET
ijpds-3935	60	10	sirna	sirna	PROPN
ijpds-3935	60	11	delivery	delivery	NOUN
ijpds-3935	60	12	mechanism	mechanism	NOUN
ijpds-3935	60	13	,	,	PUNCT
ijpds-3935	60	14	this	this	DET
ijpds-3935	60	15	immune	immune	ADJ
ijpds-3935	60	16	response	response	NOUN
ijpds-3935	60	17	can	can	AUX
ijpds-3935	60	18	be	be	AUX
ijpds-3935	60	19	particularly	particularly	ADV
ijpds-3935	60	20	problematic	problematic	ADJ
ijpds-3935	60	21	for	for	ADP
ijpds-3935	60	22	repeated	repeat	VERB
ijpds-3935	60	23	sirna	sirna	PROPN
ijpds-3935	60	24	treatment	treatment	NOUN
ijpds-3935	60	25	[	[	X
ijpds-3935	60	26	18	18	NUM
ijpds-3935	60	27	]	]	PUNCT
ijpds-3935	60	28	.	.	PUNCT
ijpds-3935	61	1	because	because	SCONJ
ijpds-3935	61	2	of	of	ADP
ijpds-3935	61	3	their	their	PRON
ijpds-3935	61	4	vulnerability	vulnerability	NOUN
ijpds-3935	61	5	to	to	ADP
ijpds-3935	61	6	nuclease	nuclease	NOUN
ijpds-3935	61	7	-	-	PUNCT
ijpds-3935	61	8	mediated	mediate	VERB
ijpds-3935	61	9	degradation	degradation	NOUN
ijpds-3935	61	10	,	,	PUNCT
ijpds-3935	61	11	sirnas	sirna	NOUN
ijpds-3935	61	12	have	have	VERB
ijpds-3935	61	13	a	a	DET
ijpds-3935	61	14	short	short	ADJ
ijpds-3935	61	15	half	half	ADJ
ijpds-3935	61	16	-	-	PUNCT
ijpds-3935	61	17	life	life	NOUN
ijpds-3935	61	18	in	in	ADP
ijpds-3935	61	19	the	the	DET
ijpds-3935	61	20	bloodstream	bloodstream	NOUN
ijpds-3935	61	21	.	.	PUNCT
ijpds-3935	62	1	moreover	moreover	ADV
ijpds-3935	62	2	,	,	PUNCT
ijpds-3935	62	3	sirnas	sirnas	PROPN
ijpds-3935	62	4	'	'	PART
ijpds-3935	62	5	bioavailability	bioavailability	NOUN
ijpds-3935	62	6	can	can	AUX
ijpds-3935	62	7	be	be	AUX
ijpds-3935	62	8	decreased	decrease	VERB
ijpds-3935	62	9	by	by	ADP
ijpds-3935	62	10	the	the	DET
ijpds-3935	62	11	kidneys	kidney	NOUN
ijpds-3935	62	12	'	'	PART
ijpds-3935	62	13	quick	quick	ADJ
ijpds-3935	62	14	clearance	clearance	NOUN
ijpds-3935	62	15	of	of	ADP
ijpds-3935	62	16	the	the	DET
ijpds-3935	62	17	molecules	molecule	NOUN
ijpds-3935	62	18	.	.	PUNCT
ijpds-3935	63	1	to	to	PART
ijpds-3935	63	2	enable	enable	VERB
ijpds-3935	63	3	the	the	DET
ijpds-3935	63	4	optimal	optimal	ADJ
ijpds-3935	63	5	distribution	distribution	NOUN
ijpds-3935	63	6	of	of	ADP
ijpds-3935	63	7	sirnas	sirna	NOUN
ijpds-3935	63	8	to	to	PART
ijpds-3935	63	9	target	target	VERB
ijpds-3935	63	10	cells	cell	NOUN
ijpds-3935	63	11	,	,	PUNCT
ijpds-3935	63	12	the	the	DET
ijpds-3935	63	13	pharmacokinetics	pharmacokinetic	NOUN
ijpds-3935	63	14	of	of	ADP
ijpds-3935	63	15	these	these	DET
ijpds-3935	63	16	molecules	molecule	NOUN
ijpds-3935	63	17	must	must	AUX
ijpds-3935	63	18	be	be	AUX
ijpds-3935	63	19	adjusted	adjust	VERB
ijpds-3935	63	20	[	[	X
ijpds-3935	63	21	19	19	NUM
ijpds-3935	63	22	]	]	PUNCT
ijpds-3935	63	23	.	.	PUNCT
ijpds-3935	64	1	tumors	tumor	NOUN
ijpds-3935	64	2	are	be	AUX
ijpds-3935	64	3	diverse	diverse	ADJ
ijpds-3935	64	4	,	,	PUNCT
ijpds-3935	64	5	and	and	CCONJ
ijpds-3935	64	6	various	various	ADJ
ijpds-3935	64	7	tumor	tumor	NOUN
ijpds-3935	64	8	cells	cell	NOUN
ijpds-3935	64	9	may	may	AUX
ijpds-3935	64	10	exhibit	exhibit	VERB
ijpds-3935	64	11	unique	unique	ADJ
ijpds-3935	64	12	patterns	pattern	NOUN
ijpds-3935	64	13	of	of	ADP
ijpds-3935	64	14	gene	gene	NOUN
ijpds-3935	64	15	expression	expression	NOUN
ijpds-3935	64	16	.	.	PUNCT
ijpds-3935	65	1	because	because	SCONJ
ijpds-3935	65	2	of	of	ADP
ijpds-3935	65	3	this	this	PRON
ijpds-3935	65	4	,	,	PUNCT
ijpds-3935	65	5	achieving	achieve	VERB
ijpds-3935	65	6	uniform	uniform	NOUN
ijpds-3935	65	7	and	and	CCONJ
ijpds-3935	65	8	efficient	efficient	ADJ
ijpds-3935	65	9	gene	gene	NOUN
ijpds-3935	65	10	silencing	silence	VERB
ijpds-3935	65	11	across	across	ADP
ijpds-3935	65	12	all	all	DET
ijpds-3935	65	13	tumor	tumor	NOUN
ijpds-3935	65	14	cells	cell	NOUN
ijpds-3935	65	15	may	may	AUX
ijpds-3935	65	16	be	be	AUX
ijpds-3935	65	17	challenging	challenge	VERB
ijpds-3935	65	18	.	.	PUNCT
ijpds-3935	66	1	because	because	SCONJ
ijpds-3935	66	2	of	of	ADP
ijpds-3935	66	3	the	the	DET
ijpds-3935	66	4	intricacy	intricacy	NOUN
ijpds-3935	66	5	of	of	ADP
ijpds-3935	66	6	sirna	sirna	PROPN
ijpds-3935	66	7	production	production	PROPN
ijpds-3935	66	8	and	and	CCONJ
ijpds-3935	66	9	delivery	delivery	NOUN
ijpds-3935	66	10	systems	system	NOUN
ijpds-3935	66	11	,	,	PUNCT
ijpds-3935	66	12	sirna	sirna	PROPN
ijpds-3935	66	13	-	-	PUNCT
ijpds-3935	66	14	based	base	VERB
ijpds-3935	66	15	medicines	medicine	NOUN
ijpds-3935	66	16	can	can	AUX
ijpds-3935	66	17	be	be	AUX
ijpds-3935	66	18	expensive	expensive	ADJ
ijpds-3935	66	19	to	to	PART
ijpds-3935	66	20	produce	produce	VERB
ijpds-3935	66	21	.	.	PUNCT
ijpds-3935	67	1	the	the	DET
ijpds-3935	67	2	cost	cost	NOUN
ijpds-3935	67	3	of	of	ADP
ijpds-3935	67	4	production	production	NOUN
ijpds-3935	67	5	may	may	AUX
ijpds-3935	67	6	restrict	restrict	VERB
ijpds-3935	67	7	the	the	DET
ijpds-3935	67	8	accessibility	accessibility	NOUN
ijpds-3935	67	9	of	of	ADP
ijpds-3935	67	10	sirna	sirna	PROPN
ijpds-3935	67	11	-	-	PUNCT
ijpds-3935	67	12	based	base	VERB
ijpds-3935	67	13	medicines	medicine	NOUN
ijpds-3935	67	14	and	and	CCONJ
ijpds-3935	67	15	the	the	DET
ijpds-3935	67	16	scope	scope	NOUN
ijpds-3935	67	17	of	of	ADP
ijpds-3935	67	18	their	their	PRON
ijpds-3935	67	19	extensive	extensive	ADJ
ijpds-3935	67	20	clinical	clinical	ADJ
ijpds-3935	67	21	use	use	NOUN
ijpds-3935	67	22	[	[	X
ijpds-3935	67	23	20	20	NUM
ijpds-3935	67	24	]	]	PUNCT
ijpds-3935	67	25	.	.	PUNCT
ijpds-3935	68	1	overall	overall	ADJ
ijpds-3935	68	2	,	,	PUNCT
ijpds-3935	68	3	while	while	SCONJ
ijpds-3935	68	4	sirna	sirna	PROPN
ijpds-3935	68	5	-	-	PUNCT
ijpds-3935	68	6	based	base	VERB
ijpds-3935	68	7	therapies	therapy	NOUN
ijpds-3935	68	8	have	have	VERB
ijpds-3935	68	9	great	great	ADJ
ijpds-3935	68	10	potential	potential	NOUN
ijpds-3935	68	11	,	,	PUNCT
ijpds-3935	68	12	there	there	PRON
ijpds-3935	68	13	are	be	VERB
ijpds-3935	68	14	still	still	ADV
ijpds-3935	68	15	several	several	ADJ
ijpds-3935	68	16	challenges	challenge	NOUN
ijpds-3935	68	17	that	that	PRON
ijpds-3935	68	18	need	need	VERB
ijpds-3935	68	19	to	to	PART
ijpds-3935	68	20	be	be	AUX
ijpds-3935	68	21	overcome	overcome	VERB
ijpds-3935	68	22	to	to	PART
ijpds-3935	68	23	ensure	ensure	VERB
ijpds-3935	68	24	their	their	PRON
ijpds-3935	68	25	clinical	clinical	ADJ
ijpds-3935	68	26	success	success	NOUN
ijpds-3935	68	27	.	.	PUNCT
ijpds-3935	69	1	researchers	researcher	NOUN
ijpds-3935	69	2	are	be	AUX
ijpds-3935	69	3	continuing	continue	VERB
ijpds-3935	69	4	to	to	PART
ijpds-3935	69	5	develop	develop	VERB
ijpds-3935	69	6	and	and	CCONJ
ijpds-3935	69	7	refine	refine	VERB
ijpds-3935	69	8	sirna	sirna	PROPN
ijpds-3935	69	9	delivery	delivery	NOUN
ijpds-3935	69	10	systems	system	NOUN
ijpds-3935	69	11	and	and	CCONJ
ijpds-3935	69	12	optimize	optimize	VERB
ijpds-3935	69	13	the	the	DET
ijpds-3935	69	14	pharmacokinetics	pharmacokinetic	NOUN
ijpds-3935	69	15	of	of	ADP
ijpds-3935	69	16	sirnas	sirna	NOUN
ijpds-3935	69	17	to	to	PART
ijpds-3935	69	18	address	address	VERB
ijpds-3935	69	19	these	these	DET
ijpds-3935	69	20	challenges	challenge	NOUN
ijpds-3935	69	21	and	and	CCONJ
ijpds-3935	69	22	advance	advance	PROPN
ijpds-3935	69	23	sirna	sirna	PROPN
ijpds-3935	69	24	-	-	PUNCT
ijpds-3935	69	25	based	base	VERB
ijpds-3935	69	26	therapies	therapy	NOUN
ijpds-3935	69	27	to	to	ADP
ijpds-3935	69	28	clinical	clinical	ADJ
ijpds-3935	69	29	practice	practice	NOUN
ijpds-3935	69	30	.	.	PUNCT
ijpds-3935	70	1	clinical	clinical	ADJ
ijpds-3935	70	2	progress	progress	NOUN
ijpds-3935	70	3	of	of	ADP
ijpds-3935	70	4	sirna	sirna	PROPN
ijpds-3935	70	5	-	-	PUNCT
ijpds-3935	70	6	based	base	VERB
ijpds-3935	70	7	cancer	cancer	NOUN
ijpds-3935	70	8	therapeutics	therapeutic	NOUN
ijpds-3935	70	9	sirna	sirna	PROPN
ijpds-3935	70	10	-	-	PUNCT
ijpds-3935	70	11	based	base	VERB
ijpds-3935	70	12	cancer	cancer	NOUN
ijpds-3935	70	13	therapeutics	therapeutic	NOUN
ijpds-3935	70	14	have	have	AUX
ijpds-3935	70	15	shown	show	VERB
ijpds-3935	70	16	great	great	ADJ
ijpds-3935	70	17	promise	promise	NOUN
ijpds-3935	70	18	in	in	ADP
ijpds-3935	70	19	preclinical	preclinical	ADJ
ijpds-3935	70	20	studies	study	NOUN
ijpds-3935	70	21	,	,	PUNCT
ijpds-3935	70	22	but	but	CCONJ
ijpds-3935	70	23	their	their	PRON
ijpds-3935	70	24	translation	translation	NOUN
ijpds-3935	70	25	to	to	ADP
ijpds-3935	70	26	clinical	clinical	ADJ
ijpds-3935	70	27	practice	practice	NOUN
ijpds-3935	70	28	has	have	AUX
ijpds-3935	70	29	been	be	AUX
ijpds-3935	70	30	challenging	challenge	VERB
ijpds-3935	70	31	.	.	PUNCT
ijpds-3935	71	1	despite	despite	SCONJ
ijpds-3935	71	2	these	these	DET
ijpds-3935	71	3	challenges	challenge	NOUN
ijpds-3935	71	4	,	,	PUNCT
ijpds-3935	71	5	several	several	ADJ
ijpds-3935	71	6	sirnabased	sirnabase	VERB
ijpds-3935	71	7	cancer	cancer	NOUN
ijpds-3935	71	8	therapeutics	therapeutic	NOUN
ijpds-3935	71	9	have	have	AUX
ijpds-3935	71	10	advanced	advance	VERB
ijpds-3935	71	11	to	to	ADP
ijpds-3935	71	12	clinical	clinical	ADJ
ijpds-3935	71	13	trials	trial	NOUN
ijpds-3935	71	14	[	[	X
ijpds-3935	71	15	21	21	NUM
ijpds-3935	71	16	]	]	PUNCT
ijpds-3935	71	17	.	.	PUNCT
ijpds-3935	72	1	several	several	ADJ
ijpds-3935	72	2	sirna	sirna	PROPN
ijpds-3935	72	3	-	-	PUNCT
ijpds-3935	72	4	based	base	VERB
ijpds-3935	72	5	therapies	therapy	NOUN
ijpds-3935	72	6	are	be	AUX
ijpds-3935	72	7	currently	currently	ADV
ijpds-3935	72	8	being	be	AUX
ijpds-3935	72	9	tested	test	VERB
ijpds-3935	72	10	in	in	ADP
ijpds-3935	72	11	humans	human	NOUN
ijpds-3935	72	12	for	for	ADP
ijpds-3935	72	13	a	a	DET
ijpds-3935	72	14	range	range	NOUN
ijpds-3935	72	15	of	of	ADP
ijpds-3935	72	16	cancer	cancer	NOUN
ijpds-3935	72	17	types	type	NOUN
ijpds-3935	72	18	,	,	PUNCT
ijpds-3935	72	19	including	include	VERB
ijpds-3935	72	20	ovarian	ovarian	ADJ
ijpds-3935	72	21	,	,	PUNCT
ijpds-3935	72	22	pancreatic	pancreatic	ADJ
ijpds-3935	72	23	,	,	PUNCT
ijpds-3935	72	24	and	and	CCONJ
ijpds-3935	72	25	liver	liver	NOUN
ijpds-3935	72	26	cancer	cancer	NOUN
ijpds-3935	72	27	[	[	X
ijpds-3935	72	28	21	21	NUM
ijpds-3935	72	29	]	]	PUNCT
ijpds-3935	72	30	.	.	PUNCT
ijpds-3935	73	1	patisiran	patisiran	PROPN
ijpds-3935	73	2	can	can	AUX
ijpds-3935	73	3	be	be	AUX
ijpds-3935	73	4	used	use	VERB
ijpds-3935	73	5	for	for	ADP
ijpds-3935	73	6	the	the	DET
ijpds-3935	73	7	treatment	treatment	NOUN
ijpds-3935	73	8	of	of	ADP
ijpds-3935	73	9	hereditary	hereditary	ADJ
ijpds-3935	73	10	transthyretin	transthyretin	ADV
ijpds-3935	73	11	-	-	PUNCT
ijpds-3935	73	12	mediated	mediate	VERB
ijpds-3935	73	13	amyloidosis	amyloidosis	NOUN
ijpds-3935	73	14	(	(	PUNCT
ijpds-3935	73	15	hattr	hattr	NOUN
ijpds-3935	73	16	)	)	PUNCT
ijpds-3935	73	17	,	,	PUNCT
ijpds-3935	73	18	a	a	DET
ijpds-3935	73	19	rare	rare	ADJ
ijpds-3935	73	20	genetic	genetic	ADJ
ijpds-3935	73	21	condition	condition	NOUN
ijpds-3935	73	22	that	that	PRON
ijpds-3935	73	23	affects	affect	VERB
ijpds-3935	73	24	the	the	DET
ijpds-3935	73	25	heart	heart	NOUN
ijpds-3935	73	26	and	and	CCONJ
ijpds-3935	73	27	nervous	nervous	ADJ
ijpds-3935	73	28	system	system	NOUN
ijpds-3935	73	29	,	,	PUNCT
ijpds-3935	73	30	patisiran	patisiran	NOUN
ijpds-3935	73	31	is	be	AUX
ijpds-3935	73	32	a	a	DET
ijpds-3935	73	33	sirna	sirna	PROPN
ijpds-3935	73	34	-	-	PUNCT
ijpds-3935	73	35	based	base	VERB
ijpds-3935	73	36	therapy	therapy	NOUN
ijpds-3935	73	37	.	.	PUNCT
ijpds-3935	74	1	in	in	ADP
ijpds-3935	74	2	clinical	clinical	ADJ
ijpds-3935	74	3	trials	trial	NOUN
ijpds-3935	74	4	,	,	PUNCT
ijpds-3935	74	5	the	the	DET
ijpds-3935	74	6	drug	drug	NOUN
ijpds-3935	74	7	patisiran	patisiran	NOUN
ijpds-3935	74	8	—	—	PUNCT
ijpds-3935	74	9	which	which	PRON
ijpds-3935	74	10	inhibits	inhibit	VERB
ijpds-3935	74	11	the	the	DET
ijpds-3935	74	12	transthyretin	transthyretin	PROPN
ijpds-3935	74	13	gene	gene	NOUN
ijpds-3935	74	14	—	—	PUNCT
ijpds-3935	74	15	promisingly	promisingly	ADV
ijpds-3935	74	16	improved	improve	VERB
ijpds-3935	74	17	patient	patient	ADJ
ijpds-3935	74	18	quality	quality	NOUN
ijpds-3935	74	19	of	of	ADP
ijpds-3935	74	20	life	life	NOUN
ijpds-3935	74	21	and	and	CCONJ
ijpds-3935	74	22	nerve	nerve	NOUN
ijpds-3935	74	23	function	function	NOUN
ijpds-3935	74	24	[	[	X
ijpds-3935	74	25	22	22	NUM
ijpds-3935	74	26	]	]	PUNCT
ijpds-3935	74	27	.	.	PUNCT
ijpds-3935	75	1	a	a	DET
ijpds-3935	75	2	sirna	sirna	PROPN
ijpds-3935	75	3	-	-	PUNCT
ijpds-3935	75	4	based	base	VERB
ijpds-3935	75	5	therapy	therapy	NOUN
ijpds-3935	75	6	called	call	VERB
ijpds-3935	75	7	inclisiran	inclisiran	NOUN
ijpds-3935	75	8	is	be	AUX
ijpds-3935	75	9	used	use	VERB
ijpds-3935	75	10	to	to	PART
ijpds-3935	75	11	treat	treat	VERB
ijpds-3935	75	12	hypercholesterolemia	hypercholesterolemia	NOUN
ijpds-3935	75	13	.	.	PUNCT
ijpds-3935	76	1	pcsk9	pcsk9	PROPN
ijpds-3935	76	2	,	,	PUNCT
ijpds-3935	76	3	a	a	DET
ijpds-3935	76	4	protein	protein	NOUN
ijpds-3935	76	5	that	that	PRON
ijpds-3935	76	6	controls	control	VERB
ijpds-3935	76	7	blood	blood	NOUN
ijpds-3935	76	8	levels	level	NOUN
ijpds-3935	76	9	of	of	ADP
ijpds-3935	76	10	ldl	ldl	NOUN
ijpds-3935	76	11	cholesterol	cholesterol	NOUN
ijpds-3935	76	12	,	,	PUNCT
ijpds-3935	76	13	is	be	AUX
ijpds-3935	76	14	the	the	DET
ijpds-3935	76	15	target	target	NOUN
ijpds-3935	76	16	of	of	ADP
ijpds-3935	76	17	inclisiran	inclisiran	NOUN
ijpds-3935	76	18	.	.	PUNCT
ijpds-3935	77	1	clinical	clinical	ADJ
ijpds-3935	77	2	trials	trial	NOUN
ijpds-3935	77	3	on	on	ADP
ijpds-3935	77	4	inclisiran	inclisiran	NOUN
ijpds-3935	77	5	have	have	AUX
ijpds-3935	77	6	yielded	yield	VERB
ijpds-3935	77	7	positive	positive	ADJ
ijpds-3935	77	8	outcomes	outcome	NOUN
ijpds-3935	77	9	,	,	PUNCT
ijpds-3935	77	10	with	with	ADP
ijpds-3935	77	11	notable	notable	ADJ
ijpds-3935	77	12	drops	drop	NOUN
ijpds-3935	77	13	in	in	ADP
ijpds-3935	77	14	ldl	ldl	NOUN
ijpds-3935	77	15	cholesterol	cholesterol	NOUN
ijpds-3935	77	16	levels	level	NOUN
ijpds-3935	77	17	[	[	X
ijpds-3935	77	18	23	23	NUM
ijpds-3935	77	19	]	]	PUNCT
ijpds-3935	77	20	.	.	PUNCT
ijpds-3935	78	1	a	a	DET
ijpds-3935	78	2	sirna	sirna	PROPN
ijpds-3935	78	3	-	-	PUNCT
ijpds-3935	78	4	based	base	VERB
ijpds-3935	78	5	therapy	therapy	NOUN
ijpds-3935	78	6	called	call	VERB
ijpds-3935	78	7	aln	aln	PROPN
ijpds-3935	78	8	-	-	PUNCT
ijpds-3935	78	9	ttrsc02	ttrsc02	NOUN
ijpds-3935	78	10	is	be	AUX
ijpds-3935	78	11	being	be	AUX
ijpds-3935	78	12	developed	develop	VERB
ijpds-3935	78	13	to	to	PART
ijpds-3935	78	14	treat	treat	VERB
ijpds-3935	78	15	attr	attr	NOUN
ijpds-3935	78	16	amyloidosis	amyloidosis	NOUN
ijpds-3935	78	17	.	.	PUNCT
ijpds-3935	79	1	in	in	ADP
ijpds-3935	79	2	clinical	clinical	ADJ
ijpds-3935	79	3	studies	study	NOUN
ijpds-3935	79	4	,	,	PUNCT
ijpds-3935	79	5	the	the	DET
ijpds-3935	79	6	transthyretin	transthyretin	PROPN
ijpds-3935	79	7	gene	gene	NOUN
ijpds-3935	79	8	-	-	PUNCT
ijpds-3935	79	9	targeting	target	VERB
ijpds-3935	79	10	drug	drug	NOUN
ijpds-3935	79	11	aln	aln	PROPN
ijpds-3935	79	12	-	-	PUNCT
ijpds-3935	79	13	ttrsc02	ttrsc02	NOUN
ijpds-3935	79	14	demonstrated	demonstrate	VERB
ijpds-3935	79	15	encouraging	encourage	VERB
ijpds-3935	79	16	outcomes	outcome	NOUN
ijpds-3935	79	17	with	with	ADP
ijpds-3935	79	18	notable	notable	ADJ
ijpds-3935	79	19	improvements	improvement	NOUN
ijpds-3935	79	20	in	in	ADP
ijpds-3935	79	21	patient	patient	ADJ
ijpds-3935	79	22	quality	quality	NOUN
ijpds-3935	79	23	of	of	ADP
ijpds-3935	79	24	life	life	NOUN
ijpds-3935	79	25	and	and	CCONJ
ijpds-3935	79	26	nerve	nerve	NOUN
ijpds-3935	79	27	function	function	NOUN
ijpds-3935	79	28	[	[	X
ijpds-3935	79	29	24	24	NUM
ijpds-3935	79	30	]	]	PUNCT
ijpds-3935	79	31	.	.	PUNCT
ijpds-3935	80	1	qpi-1002	qpi-1002	PROPN
ijpds-3935	80	2	is	be	AUX
ijpds-3935	80	3	used	use	VERB
ijpds-3935	80	4	to	to	PART
ijpds-3935	80	5	avoid	avoid	VERB
ijpds-3935	80	6	acute	acute	ADJ
ijpds-3935	80	7	kidney	kidney	NOUN
ijpds-3935	80	8	injury	injury	NOUN
ijpds-3935	80	9	,	,	PUNCT
ijpds-3935	80	10	qpi-1002	qpi-1002	NOUN
ijpds-3935	80	11	is	be	AUX
ijpds-3935	80	12	a	a	DET
ijpds-3935	80	13	sirna	sirna	PROPN
ijpds-3935	80	14	-	-	PUNCT
ijpds-3935	80	15	based	base	VERB
ijpds-3935	80	16	therapy	therapy	NOUN
ijpds-3935	80	17	.	.	PUNCT
ijpds-3935	81	1	in	in	ADP
ijpds-3935	81	2	clinical	clinical	ADJ
ijpds-3935	81	3	studies	study	NOUN
ijpds-3935	81	4	,	,	PUNCT
ijpds-3935	81	5	the	the	DET
ijpds-3935	81	6	p53	p53	NOUN
ijpds-3935	81	7	gene	gene	NOUN
ijpds-3935	81	8	-	-	PUNCT
ijpds-3935	81	9	targeting	target	VERB
ijpds-3935	81	10	drug	drug	NOUN
ijpds-3935	81	11	qpi-1002	qpi-1002	NOUN
ijpds-3935	81	12	had	have	AUX
ijpds-3935	81	13	encouraging	encouraging	ADJ
ijpds-3935	81	14	outcomes	outcome	NOUN
ijpds-3935	81	15	,	,	PUNCT
ijpds-3935	81	16	significantly	significantly	ADV
ijpds-3935	81	17	lowering	lower	VERB
ijpds-3935	81	18	the	the	DET
ijpds-3935	81	19	risk	risk	NOUN
ijpds-3935	81	20	of	of	ADP
ijpds-3935	81	21	acute	acute	ADJ
ijpds-3935	81	22	renal	renal	ADJ
ijpds-3935	81	23	damage	damage	NOUN
ijpds-3935	81	24	in	in	ADP
ijpds-3935	81	25	patients	patient	NOUN
ijpds-3935	81	26	having	have	VERB
ijpds-3935	81	27	heart	heart	NOUN
ijpds-3935	81	28	surgery	surgery	NOUN
ijpds-3935	81	29	[	[	X
ijpds-3935	81	30	25	25	NUM
ijpds-3935	81	31	]	]	PUNCT
ijpds-3935	81	32	.	.	PUNCT
ijpds-3935	82	1	although	although	SCONJ
ijpds-3935	82	2	sirna	sirna	PROPN
ijpds-3935	82	3	-	-	PUNCT
ijpds-3935	82	4	based	base	VERB
ijpds-3935	82	5	cancer	cancer	NOUN
ijpds-3935	82	6	treatments	treatment	NOUN
ijpds-3935	82	7	are	be	AUX
ijpds-3935	82	8	currently	currently	ADV
ijpds-3935	82	9	in	in	ADP
ijpds-3935	82	10	the	the	DET
ijpds-3935	82	11	early	early	ADJ
ijpds-3935	82	12	phases	phase	NOUN
ijpds-3935	82	13	of	of	ADP
ijpds-3935	82	14	clinical	clinical	ADJ
ijpds-3935	82	15	research	research	NOUN
ijpds-3935	82	16	,	,	PUNCT
ijpds-3935	82	17	they	they	PRON
ijpds-3935	82	18	have	have	VERB
ijpds-3935	82	19	the	the	DET
ijpds-3935	82	20	potential	potential	NOUN
ijpds-3935	82	21	to	to	PART
ijpds-3935	82	22	completely	completely	ADV
ijpds-3935	82	23	change	change	VERB
ijpds-3935	82	24	the	the	DET
ijpds-3935	82	25	way	way	NOUN
ijpds-3935	82	26	cancer	cancer	NOUN
ijpds-3935	82	27	is	be	AUX
ijpds-3935	82	28	treated	treat	VERB
ijpds-3935	82	29	.	.	PUNCT
ijpds-3935	83	1	it	it	PRON
ijpds-3935	83	2	is	be	AUX
ijpds-3935	83	3	hoped	hope	VERB
ijpds-3935	83	4	that	that	SCONJ
ijpds-3935	83	5	sirna	sirna	PROPN
ijpds-3935	83	6	-	-	PUNCT
ijpds-3935	83	7	based	base	VERB
ijpds-3935	83	8	cancer	cancer	NOUN
ijpds-3935	83	9	treatments	treatment	NOUN
ijpds-3935	83	10	would	would	AUX
ijpds-3935	83	11	advance	advance	VERB
ijpds-3935	83	12	and	and	CCONJ
ijpds-3935	83	13	eventually	eventually	ADV
ijpds-3935	83	14	become	become	VERB
ijpds-3935	83	15	a	a	DET
ijpds-3935	83	16	standard	standard	ADJ
ijpds-3935	83	17	component	component	NOUN
ijpds-3935	83	18	of	of	ADP
ijpds-3935	83	19	cancer	cancer	NOUN
ijpds-3935	83	20	treatment	treatment	NOUN
ijpds-3935	83	21	with	with	ADP
ijpds-3935	83	22	continued	continue	VERB
ijpds-3935	83	23	research	research	NOUN
ijpds-3935	83	24	and	and	CCONJ
ijpds-3935	83	25	clinical	clinical	ADJ
ijpds-3935	83	26	studies	study	NOUN
ijpds-3935	83	27	[	[	X
ijpds-3935	83	28	5	5	NUM
ijpds-3935	83	29	]	]	PUNCT
ijpds-3935	83	30	.	.	PUNCT
ijpds-3935	84	1	sirna	sirna	PROPN
ijpds-3935	84	2	-	-	PUNCT
ijpds-3935	84	3	based	base	VERB
ijpds-3935	84	4	therapies	therapy	NOUN
ijpds-3935	84	5	for	for	ADP
ijpds-3935	84	6	cancer	cancer	NOUN
ijpds-3935	84	7	treatment	treatment	NOUN
ijpds-3935	84	8	.	.	PUNCT
ijpds-3935	85	1	the	the	DET
ijpds-3935	85	2	potential	potential	NOUN
ijpds-3935	85	3	of	of	ADP
ijpds-3935	85	4	sirna	sirna	PROPN
ijpds-3935	85	5	-	-	PUNCT
ijpds-3935	85	6	based	base	VERB
ijpds-3935	85	7	therapies	therapy	NOUN
ijpds-3935	85	8	for	for	ADP
ijpds-3935	85	9	cancer	cancer	NOUN
ijpds-3935	85	10	treatment	treatment	NOUN
ijpds-3935	85	11	is	be	AUX
ijpds-3935	85	12	significant	significant	ADJ
ijpds-3935	85	13	,	,	PUNCT
ijpds-3935	85	14	and	and	CCONJ
ijpds-3935	85	15	these	these	DET
ijpds-3935	85	16	therapies	therapy	NOUN
ijpds-3935	85	17	hold	hold	VERB
ijpds-3935	85	18	great	great	ADJ
ijpds-3935	85	19	promise	promise	NOUN
ijpds-3935	85	20	for	for	ADP
ijpds-3935	85	21	improving	improve	VERB
ijpds-3935	85	22	the	the	DET
ijpds-3935	85	23	effectiveness	effectiveness	NOUN
ijpds-3935	85	24	of	of	ADP
ijpds-3935	85	25	cancer	cancer	NOUN
ijpds-3935	85	26	treatment	treatment	NOUN
ijpds-3935	85	27	.	.	PUNCT
ijpds-3935	86	1	targeted	target	VERB
ijpds-3935	86	2	gene	gene	NOUN
ijpds-3935	86	3	silencing	silence	VERB
ijpds-3935	86	4	is	be	AUX
ijpds-3935	86	5	a	a	DET
ijpds-3935	86	6	very	very	ADV
ijpds-3935	86	7	specific	specific	ADJ
ijpds-3935	86	8	and	and	CCONJ
ijpds-3935	86	9	exact	exact	ADJ
ijpds-3935	86	10	sirna	sirna	PROPN
ijpds-3935	86	11	-	-	PUNCT
ijpds-3935	86	12	based	base	VERB
ijpds-3935	86	13	therapeutics	therapeutic	NOUN
ijpds-3935	86	14	can	can	AUX
ijpds-3935	86	15	be	be	AUX
ijpds-3935	86	16	created	create	VERB
ijpds-3935	86	17	to	to	PART
ijpds-3935	86	18	target	target	VERB
ijpds-3935	86	19	particular	particular	ADJ
ijpds-3935	86	20	genes	gene	NOUN
ijpds-3935	86	21	that	that	PRON
ijpds-3935	86	22	contribute	contribute	VERB
ijpds-3935	86	23	to	to	ADP
ijpds-3935	86	24	the	the	DET
ijpds-3935	86	25	development	development	NOUN
ijpds-3935	86	26	of	of	ADP
ijpds-3935	86	27	cancer	cancer	NOUN
ijpds-3935	86	28	.	.	PUNCT
ijpds-3935	87	1	this	this	DET
ijpds-3935	87	2	method	method	NOUN
ijpds-3935	87	3	of	of	ADP
ijpds-3935	87	4	targeted	target	VERB
ijpds-3935	87	5	gene	gene	NOUN
ijpds-3935	87	6	silencing	silence	VERB
ijpds-3935	87	7	may	may	AUX
ijpds-3935	87	8	help	help	VERB
ijpds-3935	87	9	to	to	PART
ijpds-3935	87	10	lessen	lessen	VERB
ijpds-3935	87	11	the	the	DET
ijpds-3935	87	12	toxicity	toxicity	NOUN
ijpds-3935	87	13	and	and	CCONJ
ijpds-3935	87	14	side	side	NOUN
ijpds-3935	87	15	effects	effect	NOUN
ijpds-3935	87	16	of	of	ADP
ijpds-3935	87	17	conventional	conventional	ADJ
ijpds-3935	87	18	cancer	cancer	NOUN
ijpds-3935	87	19	therapies	therapy	NOUN
ijpds-3935	87	20	like	like	ADP
ijpds-3935	87	21	chemotherapy	chemotherapy	NOUN
ijpds-3935	87	22	[	[	X
ijpds-3935	87	23	26	26	NUM
ijpds-3935	87	24	]	]	PUNCT
ijpds-3935	87	25	.	.	PUNCT
ijpds-3935	88	1	potentially	potentially	ADV
ijpds-3935	88	2	synergistic	synergistic	ADJ
ijpds-3935	88	3	with	with	ADP
ijpds-3935	88	4	other	other	ADJ
ijpds-3935	88	5	therapies	therapy	NOUN
ijpds-3935	88	6	where	where	SCONJ
ijpds-3935	88	7	sirna	sirna	PROPN
ijpds-3935	88	8	-	-	PUNCT
ijpds-3935	88	9	based	base	VERB
ijpds-3935	88	10	cancer	cancer	NOUN
ijpds-3935	88	11	therapies	therapy	NOUN
ijpds-3935	88	12	may	may	AUX
ijpds-3935	88	13	be	be	AUX
ijpds-3935	88	14	used	use	VERB
ijpds-3935	88	15	in	in	ADP
ijpds-3935	88	16	conjunction	conjunction	NOUN
ijpds-3935	88	17	with	with	ADP
ijpds-3935	88	18	other	other	ADJ
ijpds-3935	88	19	cancer	cancer	NOUN
ijpds-3935	88	20	therapies	therapy	NOUN
ijpds-3935	88	21	,	,	PUNCT
ijpds-3935	88	22	such	such	ADJ
ijpds-3935	88	23	as	as	ADP
ijpds-3935	88	24	chemotherapy	chemotherapy	NOUN
ijpds-3935	88	25	or	or	CCONJ
ijpds-3935	88	26	immunotherapy	immunotherapy	NOUN
ijpds-3935	88	27	,	,	PUNCT
ijpds-3935	88	28	to	to	PART
ijpds-3935	88	29	increase	increase	VERB
ijpds-3935	88	30	the	the	DET
ijpds-3935	88	31	efficacy	efficacy	NOUN
ijpds-3935	88	32	of	of	ADP
ijpds-3935	88	33	both	both	PRON
ijpds-3935	88	34	.	.	PUNCT
ijpds-3935	89	1	for	for	ADP
ijpds-3935	89	2	example	example	NOUN
ijpds-3935	89	3	,	,	PUNCT
ijpds-3935	89	4	sirna	sirna	PROPN
ijpds-3935	89	5	-	-	PUNCT
ijpds-3935	89	6	based	base	VERB
ijpds-3935	89	7	therapeutics	therapeutic	NOUN
ijpds-3935	89	8	could	could	AUX
ijpds-3935	89	9	be	be	AUX
ijpds-3935	89	10	used	use	VERB
ijpds-3935	89	11	to	to	PART
ijpds-3935	89	12	target	target	VERB
ijpds-3935	89	13	genes	gene	NOUN
ijpds-3935	89	14	that	that	PRON
ijpds-3935	89	15	give	give	VERB
ijpds-3935	89	16	resistance	resistance	NOUN
ijpds-3935	89	17	to	to	ADP
ijpds-3935	89	18	chemotherapy	chemotherapy	NOUN
ijpds-3935	89	19	,	,	PUNCT
ijpds-3935	89	20	thus	thus	ADV
ijpds-3935	89	21	enhancing	enhance	VERB
ijpds-3935	89	22	the	the	DET
ijpds-3935	89	23	efficacy	efficacy	NOUN
ijpds-3935	89	24	of	of	ADP
ijpds-3935	89	25	the	the	DET
ijpds-3935	89	26	chemotherapy	chemotherapy	NOUN
ijpds-3935	90	1	[	[	X
ijpds-3935	90	2	27	27	NUM
ijpds-3935	90	3	]	]	PUNCT
ijpds-3935	90	4	.	.	PUNCT
ijpds-3935	91	1	sirna	sirna	PROPN
ijpds-3935	91	2	-	-	PUNCT
ijpds-3935	91	3	based	base	VERB
ijpds-3935	91	4	therapies	therapy	NOUN
ijpds-3935	91	5	can	can	AUX
ijpds-3935	91	6	be	be	AUX
ijpds-3935	91	7	designed	design	VERB
ijpds-3935	91	8	to	to	PART
ijpds-3935	91	9	target	target	VERB
ijpds-3935	91	10	a	a	DET
ijpds-3935	91	11	wide	wide	ADJ
ijpds-3935	91	12	range	range	NOUN
ijpds-3935	91	13	of	of	ADP
ijpds-3935	91	14	genes	gene	NOUN
ijpds-3935	91	15	that	that	PRON
ijpds-3935	91	16	play	play	VERB
ijpds-3935	91	17	a	a	DET
ijpds-3935	91	18	role	role	NOUN
ijpds-3935	91	19	in	in	ADP
ijpds-3935	91	20	cancer	cancer	NOUN
ijpds-3935	91	21	progression	progression	NOUN
ijpds-3935	91	22	,	,	PUNCT
ijpds-3935	91	23	including	include	VERB
ijpds-3935	91	24	oncogenes	oncogene	NOUN
ijpds-3935	91	25	,	,	PUNCT
ijpds-3935	91	26	tumor	tumor	NOUN
ijpds-3935	91	27	genes	gene	NOUN
ijpds-3935	91	28	,	,	PUNCT
ijpds-3935	91	29	and	and	CCONJ
ijpds-3935	91	30	genes	gene	NOUN
ijpds-3935	91	31	involved	involve	VERB
ijpds-3935	91	32	in	in	ADP
ijpds-3935	91	33	angiogenesis	angiogenesis	NOUN
ijpds-3935	91	34	and	and	CCONJ
ijpds-3935	91	35	metastasis	metastasis	NOUN
ijpds-3935	91	36	.	.	PUNCT
ijpds-3935	92	1	sirna	sirna	PROPN
ijpds-3935	92	2	-	-	PUNCT
ijpds-3935	92	3	based	base	VERB
ijpds-3935	92	4	therapies	therapy	NOUN
ijpds-3935	92	5	can	can	AUX
ijpds-3935	92	6	be	be	AUX
ijpds-3935	92	7	customized	customize	VERB
ijpds-3935	92	8	for	for	ADP
ijpds-3935	92	9	individual	individual	ADJ
ijpds-3935	92	10	patients	patient	NOUN
ijpds-3935	92	11	based	base	VERB
ijpds-3935	92	12	on	on	ADP
ijpds-3935	92	13	their	their	PRON
ijpds-3935	92	14	genetic	genetic	ADJ
ijpds-3935	92	15	profile	profile	NOUN
ijpds-3935	92	16	,	,	PUNCT
ijpds-3935	92	17	which	which	PRON
ijpds-3935	92	18	could	could	AUX
ijpds-3935	92	19	potentially	potentially	ADV
ijpds-3935	92	20	lead	lead	VERB
ijpds-3935	92	21	to	to	ADP
ijpds-3935	92	22	more	more	ADV
ijpds-3935	92	23	effective	effective	ADJ
ijpds-3935	92	24	and	and	CCONJ
ijpds-3935	92	25	personalized	personalized	ADJ
ijpds-3935	92	26	cancer	cancer	NOUN
ijpds-3935	92	27	treatment	treatment	NOUN
ijpds-3935	92	28	.	.	PUNCT
ijpds-3935	93	1	sirna	sirna	PROPN
ijpds-3935	93	2	-	-	PUNCT
ijpds-3935	93	3	based	base	VERB
ijpds-3935	93	4	therapies	therapy	NOUN
ijpds-3935	93	5	can	can	AUX
ijpds-3935	93	6	be	be	AUX
ijpds-3935	93	7	customized	customize	VERB
ijpds-3935	93	8	for	for	ADP
ijpds-3935	93	9	individual	individual	ADJ
ijpds-3935	93	10	patients	patient	NOUN
ijpds-3935	93	11	based	base	VERB
ijpds-3935	93	12	on	on	ADP
ijpds-3935	93	13	their	their	PRON
ijpds-3935	93	14	genetic	genetic	ADJ
ijpds-3935	93	15	profile	profile	NOUN
ijpds-3935	93	16	,	,	PUNCT
ijpds-3935	93	17	which	which	PRON
ijpds-3935	93	18	could	could	AUX
ijpds-3935	93	19	potentially	potentially	ADV
ijpds-3935	93	20	lead	lead	VERB
ijpds-3935	93	21	to	to	ADP
ijpds-3935	93	22	more	more	ADV
ijpds-3935	93	23	effective	effective	ADJ
ijpds-3935	93	24	and	and	CCONJ
ijpds-3935	93	25	personalized	personalized	ADJ
ijpds-3935	93	26	cancer	cancer	NOUN
ijpds-3935	93	27	treatment	treatment	NOUN
ijpds-3935	93	28	[	[	X
ijpds-3935	93	29	28	28	NUM
ijpds-3935	93	30	]	]	PUNCT
ijpds-3935	93	31	.	.	PUNCT
ijpds-3935	94	1	sirna	sirna	PROPN
ijpds-3935	94	2	-	-	PUNCT
ijpds-3935	94	3	based	base	VERB
ijpds-3935	94	4	therapies	therapy	NOUN
ijpds-3935	94	5	can	can	AUX
ijpds-3935	94	6	be	be	AUX
ijpds-3935	94	7	customized	customize	VERB
ijpds-3935	94	8	for	for	ADP
ijpds-3935	94	9	individual	individual	ADJ
ijpds-3935	94	10	patients	patient	NOUN
ijpds-3935	94	11	based	base	VERB
ijpds-3935	94	12	on	on	ADP
ijpds-3935	94	13	their	their	PRON
ijpds-3935	94	14	genetic	genetic	ADJ
ijpds-3935	94	15	profile	profile	NOUN
ijpds-3935	94	16	,	,	PUNCT
ijpds-3935	94	17	which	which	PRON
ijpds-3935	94	18	could	could	AUX
ijpds-3935	94	19	potentially	potentially	ADV
ijpds-3935	94	20	lead	lead	VERB
ijpds-3935	94	21	to	to	ADP
ijpds-3935	94	22	more	more	ADV
ijpds-3935	94	23	effective	effective	ADJ
ijpds-3935	94	24	and	and	CCONJ
ijpds-3935	94	25	personalized	personalized	ADJ
ijpds-3935	94	26	cancer	cancer	NOUN
ijpds-3935	94	27	treatment	treatment	NOUN
ijpds-3935	94	28	[	[	X
ijpds-3935	94	29	27	27	NUM
ijpds-3935	94	30	]	]	PUNCT
ijpds-3935	94	31	.	.	PUNCT
ijpds-3935	95	1	sirna	sirna	PROPN
ijpds-3935	95	2	-	-	PUNCT
ijpds-3935	95	3	based	base	VERB
ijpds-3935	95	4	therapies	therapy	NOUN
ijpds-3935	95	5	are	be	AUX
ijpds-3935	95	6	highly	highly	ADV
ijpds-3935	95	7	specific	specific	ADJ
ijpds-3935	95	8	,	,	PUNCT
ijpds-3935	95	9	which	which	PRON
ijpds-3935	95	10	means	mean	VERB
ijpds-3935	95	11	that	that	SCONJ
ijpds-3935	95	12	they	they	PRON
ijpds-3935	95	13	have	have	VERB
ijpds-3935	95	14	the	the	DET
ijpds-3935	95	15	potential	potential	NOUN
ijpds-3935	95	16	to	to	PART
ijpds-3935	95	17	be	be	AUX
ijpds-3935	95	18	less	less	ADV
ijpds-3935	95	19	toxic	toxic	ADJ
ijpds-3935	95	20	than	than	ADP
ijpds-3935	95	21	traditional	traditional	ADJ
ijpds-3935	95	22	cancer	cancer	NOUN
ijpds-3935	95	23	treatments	treatment	NOUN
ijpds-3935	95	24	,	,	PUNCT
ijpds-3935	95	25	which	which	PRON
ijpds-3935	95	26	can	can	AUX
ijpds-3935	95	27	have	have	VERB
ijpds-3935	95	28	significant	significant	ADJ
ijpds-3935	95	29	side	side	NOUN
ijpds-3935	95	30	effects	effect	NOUN
ijpds-3935	95	31	[	[	X
ijpds-3935	95	32	5	5	NUM
ijpds-3935	95	33	]	]	PUNCT
ijpds-3935	95	34	.	.	PUNCT
ijpds-3935	96	1	despite	despite	SCONJ
ijpds-3935	96	2	these	these	DET
ijpds-3935	96	3	potential	potential	ADJ
ijpds-3935	96	4	benefits	benefit	NOUN
ijpds-3935	96	5	,	,	PUNCT
ijpds-3935	96	6	there	there	PRON
ijpds-3935	96	7	are	be	VERB
ijpds-3935	96	8	still	still	ADV
ijpds-3935	96	9	several	several	ADJ
ijpds-3935	96	10	challenges	challenge	NOUN
ijpds-3935	96	11	associated	associate	VERB
ijpds-3935	96	12	with	with	ADP
ijpds-3935	96	13	sirna	sirna	PROPN
ijpds-3935	96	14	-	-	PUNCT
ijpds-3935	96	15	based	base	VERB
ijpds-3935	96	16	therapies	therapy	NOUN
ijpds-3935	96	17	,	,	PUNCT
ijpds-3935	96	18	as	as	SCONJ
ijpds-3935	96	19	discussed	discuss	VERB
ijpds-3935	96	20	earlier	early	ADV
ijpds-3935	96	21	.	.	PUNCT
ijpds-3935	97	1	the	the	DET
ijpds-3935	97	2	delivery	delivery	NOUN
ijpds-3935	97	3	of	of	ADP
ijpds-3935	97	4	sirnas	sirna	NOUN
ijpds-3935	97	5	to	to	PART
ijpds-3935	97	6	target	target	VERB
ijpds-3935	97	7	cells	cell	NOUN
ijpds-3935	97	8	is	be	AUX
ijpds-3935	97	9	one	one	NUM
ijpds-3935	97	10	of	of	ADP
ijpds-3935	97	11	the	the	DET
ijpds-3935	97	12	major	major	ADJ
ijpds-3935	97	13	challenges	challenge	NOUN
ijpds-3935	97	14	associated	associate	VERB
ijpds-3935	97	15	with	with	ADP
ijpds-3935	97	16	sirna	sirna	PROPN
ijpds-3935	97	17	-	-	PUNCT
ijpds-3935	97	18	based	base	VERB
ijpds-3935	97	19	therapies	therapy	NOUN
ijpds-3935	97	20	.	.	PUNCT
ijpds-3935	98	1	additionally	additionally	ADV
ijpds-3935	98	2	,	,	PUNCT
ijpds-3935	98	3	the	the	DET
ijpds-3935	98	4	high	high	ADJ
ijpds-3935	98	5	cost	cost	NOUN
ijpds-3935	98	6	of	of	ADP
ijpds-3935	98	7	manufacturing	manufacturing	NOUN
ijpds-3935	98	8	and	and	CCONJ
ijpds-3935	98	9	the	the	DET
ijpds-3935	98	10	potential	potential	NOUN
ijpds-3935	98	11	for	for	ADP
ijpds-3935	98	12	off	off	ADP
ijpds-3935	98	13	-	-	PUNCT
ijpds-3935	98	14	target	target	NOUN
ijpds-3935	98	15	effects	effect	NOUN
ijpds-3935	98	16	are	be	AUX
ijpds-3935	98	17	also	also	ADV
ijpds-3935	98	18	significant	significant	ADJ
ijpds-3935	98	19	challenges	challenge	NOUN
ijpds-3935	98	20	that	that	PRON
ijpds-3935	98	21	need	need	VERB
ijpds-3935	98	22	to	to	PART
ijpds-3935	98	23	be	be	AUX
ijpds-3935	98	24	addressed	address	VERB
ijpds-3935	98	25	.	.	PUNCT
ijpds-3935	99	1	overall	overall	ADV
ijpds-3935	99	2	,	,	PUNCT
ijpds-3935	99	3	sirna	sirna	PROPN
ijpds-3935	99	4	-	-	PUNCT
ijpds-3935	99	5	based	base	VERB
ijpds-3935	99	6	therapies	therapy	NOUN
ijpds-3935	99	7	have	have	VERB
ijpds-3935	99	8	the	the	DET
ijpds-3935	99	9	potential	potential	NOUN
ijpds-3935	99	10	to	to	PART
ijpds-3935	99	11	significantly	significantly	ADV
ijpds-3935	99	12	improve	improve	VERB
ijpds-3935	99	13	cancer	cancer	NOUN
ijpds-3935	99	14	treatment	treatment	NOUN
ijpds-3935	99	15	,	,	PUNCT
ijpds-3935	99	16	but	but	CCONJ
ijpds-3935	99	17	further	further	ADJ
ijpds-3935	99	18	research	research	NOUN
ijpds-3935	99	19	and	and	CCONJ
ijpds-3935	99	20	development	development	NOUN
ijpds-3935	99	21	are	be	AUX
ijpds-3935	99	22	needed	need	VERB
ijpds-3935	99	23	to	to	PART
ijpds-3935	99	24	optimize	optimize	VERB
ijpds-3935	99	25	their	their	PRON
ijpds-3935	99	26	efficacy	efficacy	NOUN
ijpds-3935	99	27	and	and	CCONJ
ijpds-3935	99	28	safety	safety	NOUN
ijpds-3935	99	29	.	.	PUNCT
ijpds-3935	100	1	with	with	ADP
ijpds-3935	100	2	ongoing	ongoing	ADJ
ijpds-3935	100	3	research	research	NOUN
ijpds-3935	100	4	and	and	CCONJ
ijpds-3935	100	5	clinical	clinical	ADJ
ijpds-3935	100	6	trials	trial	NOUN
ijpds-3935	100	7	,	,	PUNCT
ijpds-3935	100	8	it	it	PRON
ijpds-3935	100	9	is	be	AUX
ijpds-3935	100	10	hoped	hope	VERB
ijpds-3935	100	11	that	that	SCONJ
ijpds-3935	100	12	sirna	sirna	PROPN
ijpds-3935	100	13	-	-	PUNCT
ijpds-3935	100	14	based	base	VERB
ijpds-3935	100	15	therapies	therapy	NOUN
ijpds-3935	100	16	will	will	AUX
ijpds-3935	100	17	continue	continue	VERB
ijpds-3935	100	18	to	to	PART
ijpds-3935	100	19	advance	advance	VERB
ijpds-3935	100	20	and	and	CCONJ
ijpds-3935	100	21	eventually	eventually	ADV
ijpds-3935	100	22	become	become	VERB
ijpds-3935	100	23	a	a	DET
ijpds-3935	100	24	routine	routine	ADJ
ijpds-3935	100	25	part	part	NOUN
ijpds-3935	100	26	of	of	ADP
ijpds-3935	100	27	cancer	cancer	NOUN
ijpds-3935	100	28	treatment	treatment	NOUN
ijpds-3935	100	29	.	.	PUNCT
ijpds-3935	101	1	shanbhag	shanbhag	NOUN
ijpds-3935	101	2	et	et	PROPN
ijpds-3935	101	3	al	al	PROPN
ijpds-3935	101	4	.	.	PUNCT
ijpds-3935	102	1	cancer	cancer	NOUN
ijpds-3935	102	2	therapy	therapy	NOUN
ijpds-3935	102	3	:	:	PUNCT
ijpds-3935	102	4	an	an	DET
ijpds-3935	102	5	overview	overview	NOUN
ijpds-3935	102	6	of	of	ADP
ijpds-3935	102	7	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	102	8	strategies	strategy	NOUN
ijpds-3935	102	9	vol	vol	VERB
ijpds-3935	102	10	2|	2|	NUM
ijpds-3935	102	11	issue	issue	NOUN
ijpds-3935	102	12	2	2	NUM
ijpds-3935	102	13	|	|	ADV
ijpds-3935	102	14	apr	apr	ADV
ijpds-3935	102	15	–	–	PUNCT
ijpds-3935	102	16	jun	jun	PROPN
ijpds-3935	102	17	2023	2023	NUM
ijpds-3935	102	18	indian	indian	PROPN
ijpds-3935	102	19	j	j	PROPN
ijpds-3935	102	20	pharm	pharm	PROPN
ijpds-3935	102	21	drug	drug	PROPN
ijpds-3935	102	22	studies	study	NOUN
ijpds-3935	102	23	|	|	ADV
ijpds-3935	102	24	66	66	NUM
ijpds-3935	102	25	fig	fig	NOUN
ijpds-3935	102	26	no.3	no.3	NOUN
ijpds-3935	102	27	:	:	PUNCT
ijpds-3935	102	28	targeted	target	VERB
ijpds-3935	102	29	gene	gene	NOUN
ijpds-3935	102	30	silencing	silence	VERB
ijpds-3935	102	31	[	[	PUNCT
ijpds-3935	102	32	29	29	NUM
ijpds-3935	102	33	]	]	PUNCT
ijpds-3935	102	34	fig	fig	NOUN
ijpds-3935	102	35	no.4	no.4	PROPN
ijpds-3935	102	36	:	:	PUNCT
ijpds-3935	102	37	synergistic	synergistic	ADJ
ijpds-3935	102	38	chemotherapy	chemotherapy	NOUN
ijpds-3935	102	39	towards	towards	ADP
ijpds-3935	102	40	breast	breast	NOUN
ijpds-3935	102	41	cancer	cancer	NOUN
ijpds-3935	102	42	[	[	X
ijpds-3935	102	43	30	30	NUM
ijpds-3935	102	44	]	]	X
ijpds-3935	102	45	future	future	ADJ
ijpds-3935	102	46	directions	direction	NOUN
ijpds-3935	102	47	in	in	ADP
ijpds-3935	102	48	the	the	DET
ijpds-3935	102	49	field	field	NOUN
ijpds-3935	102	50	of	of	ADP
ijpds-3935	102	51	sirna	sirna	PROPN
ijpds-3935	102	52	-	-	PUNCT
ijpds-3935	102	53	mediated	mediate	VERB
ijpds-3935	102	54	silencing	silencing	NOUN
ijpds-3935	102	55	of	of	ADP
ijpds-3935	102	56	oncogenes	oncogene	NOUN
ijpds-3935	102	57	for	for	ADP
ijpds-3935	102	58	cancer	cancer	NOUN
ijpds-3935	102	59	therapy	therapy	NOUN
ijpds-3935	102	60	the	the	DET
ijpds-3935	102	61	field	field	NOUN
ijpds-3935	102	62	of	of	ADP
ijpds-3935	102	63	sirna	sirna	PROPN
ijpds-3935	102	64	-	-	PUNCT
ijpds-3935	102	65	mediated	mediate	VERB
ijpds-3935	102	66	oncogene	oncogene	NOUN
ijpds-3935	102	67	silencing	silence	VERB
ijpds-3935	102	68	for	for	ADP
ijpds-3935	102	69	cancer	cancer	NOUN
ijpds-3935	102	70	therapy	therapy	NOUN
ijpds-3935	102	71	is	be	AUX
ijpds-3935	102	72	quickly	quickly	ADV
ijpds-3935	102	73	developing	develop	VERB
ijpds-3935	102	74	,	,	PUNCT
ijpds-3935	102	75	and	and	CCONJ
ijpds-3935	102	76	it	it	PRON
ijpds-3935	102	77	is	be	AUX
ijpds-3935	102	78	moving	move	VERB
ijpds-3935	102	79	in	in	ADP
ijpds-3935	102	80	fascinating	fascinating	ADJ
ijpds-3935	102	81	directions	direction	NOUN
ijpds-3935	102	82	.	.	PUNCT
ijpds-3935	103	1	combining	combine	VERB
ijpds-3935	103	2	sirna	sirna	PROPN
ijpds-3935	103	3	-	-	PUNCT
ijpds-3935	103	4	based	base	VERB
ijpds-3935	103	5	therapies	therapy	NOUN
ijpds-3935	103	6	with	with	ADP
ijpds-3935	103	7	other	other	ADJ
ijpds-3935	103	8	cancer	cancer	NOUN
ijpds-3935	103	9	treatments	treatment	NOUN
ijpds-3935	103	10	,	,	PUNCT
ijpds-3935	103	11	such	such	ADJ
ijpds-3935	103	12	as	as	ADP
ijpds-3935	103	13	chemotherapy	chemotherapy	NOUN
ijpds-3935	103	14	or	or	CCONJ
ijpds-3935	103	15	immunotherapy	immunotherapy	NOUN
ijpds-3935	103	16	,	,	PUNCT
ijpds-3935	103	17	is	be	AUX
ijpds-3935	103	18	one	one	NUM
ijpds-3935	103	19	of	of	ADP
ijpds-3935	103	20	the	the	DET
ijpds-3935	103	21	most	most	ADV
ijpds-3935	103	22	promising	promising	ADJ
ijpds-3935	103	23	areas	area	NOUN
ijpds-3935	103	24	of	of	ADP
ijpds-3935	103	25	research	research	NOUN
ijpds-3935	103	26	.	.	PUNCT
ijpds-3935	104	1	it	it	PRON
ijpds-3935	104	2	might	might	AUX
ijpds-3935	104	3	be	be	AUX
ijpds-3935	104	4	possible	possible	ADJ
ijpds-3935	104	5	to	to	PART
ijpds-3935	104	6	improve	improve	VERB
ijpds-3935	104	7	therapeutic	therapeutic	ADJ
ijpds-3935	104	8	outcomes	outcome	NOUN
ijpds-3935	104	9	by	by	ADP
ijpds-3935	104	10	combining	combine	VERB
ijpds-3935	104	11	sirna	sirna	PROPN
ijpds-3935	104	12	-	-	PUNCT
ijpds-3935	104	13	based	base	VERB
ijpds-3935	104	14	medicines	medicine	NOUN
ijpds-3935	104	15	with	with	ADP
ijpds-3935	104	16	other	other	ADJ
ijpds-3935	104	17	cancer	cancer	NOUN
ijpds-3935	104	18	medications	medication	NOUN
ijpds-3935	104	19	[	[	X
ijpds-3935	104	20	31	31	NUM
ijpds-3935	104	21	]	]	PUNCT
ijpds-3935	104	22	.	.	PUNCT
ijpds-3935	105	1	a	a	DET
ijpds-3935	105	2	key	key	ADJ
ijpds-3935	105	3	area	area	NOUN
ijpds-3935	105	4	of	of	ADP
ijpds-3935	105	5	research	research	NOUN
ijpds-3935	105	6	focuses	focus	VERB
ijpds-3935	105	7	on	on	ADP
ijpds-3935	105	8	delivering	deliver	VERB
ijpds-3935	105	9	sirnas	sirna	NOUN
ijpds-3935	105	10	to	to	ADP
ijpds-3935	105	11	cancer	cancer	NOUN
ijpds-3935	105	12	cells	cell	NOUN
ijpds-3935	105	13	in	in	ADP
ijpds-3935	105	14	certain	certain	ADJ
ijpds-3935	105	15	tissues	tissue	NOUN
ijpds-3935	105	16	.	.	PUNCT
ijpds-3935	106	1	to	to	PART
ijpds-3935	106	2	deliver	deliver	VERB
ijpds-3935	106	3	sirnas	sirna	NOUN
ijpds-3935	106	4	to	to	ADP
ijpds-3935	106	5	cancer	cancer	NOUN
ijpds-3935	106	6	cells	cell	NOUN
ijpds-3935	106	7	in	in	ADP
ijpds-3935	106	8	certain	certain	ADJ
ijpds-3935	106	9	organs	organ	NOUN
ijpds-3935	106	10	while	while	SCONJ
ijpds-3935	106	11	limiting	limit	VERB
ijpds-3935	106	12	toxicity	toxicity	NOUN
ijpds-3935	106	13	and	and	CCONJ
ijpds-3935	106	14	off	off	ADP
ijpds-3935	106	15	-	-	PUNCT
ijpds-3935	106	16	target	target	NOUN
ijpds-3935	106	17	effects	effect	NOUN
ijpds-3935	106	18	,	,	PUNCT
ijpds-3935	106	19	researchers	researcher	NOUN
ijpds-3935	106	20	are	be	AUX
ijpds-3935	106	21	creating	create	VERB
ijpds-3935	106	22	innovative	innovative	ADJ
ijpds-3935	106	23	delivery	delivery	NOUN
ijpds-3935	106	24	mechanisms	mechanism	NOUN
ijpds-3935	106	25	[	[	X
ijpds-3935	106	26	32	32	NUM
ijpds-3935	106	27	]	]	PUNCT
ijpds-3935	106	28	.	.	PUNCT
ijpds-3935	107	1	sirna	sirna	PROPN
ijpds-3935	107	2	-	-	PUNCT
ijpds-3935	107	3	based	base	VERB
ijpds-3935	107	4	therapies	therapy	NOUN
ijpds-3935	107	5	can	can	AUX
ijpds-3935	107	6	be	be	AUX
ijpds-3935	107	7	customized	customize	VERB
ijpds-3935	107	8	for	for	ADP
ijpds-3935	107	9	individual	individual	ADJ
ijpds-3935	107	10	patients	patient	NOUN
ijpds-3935	107	11	based	base	VERB
ijpds-3935	107	12	on	on	ADP
ijpds-3935	107	13	their	their	PRON
ijpds-3935	107	14	genetic	genetic	ADJ
ijpds-3935	107	15	profiles	profile	NOUN
ijpds-3935	107	16	.	.	PUNCT
ijpds-3935	108	1	developing	develop	VERB
ijpds-3935	108	2	methods	method	NOUN
ijpds-3935	108	3	to	to	PART
ijpds-3935	108	4	identify	identify	VERB
ijpds-3935	108	5	patient	patient	NOUN
ijpds-3935	108	6	-	-	PUNCT
ijpds-3935	108	7	specific	specific	ADJ
ijpds-3935	108	8	targets	target	NOUN
ijpds-3935	108	9	and	and	CCONJ
ijpds-3935	108	10	designing	design	VERB
ijpds-3935	108	11	sirnas	sirna	NOUN
ijpds-3935	108	12	that	that	PRON
ijpds-3935	108	13	specifically	specifically	ADV
ijpds-3935	108	14	target	target	VERB
ijpds-3935	108	15	these	these	DET
ijpds-3935	108	16	genes	gene	NOUN
ijpds-3935	108	17	is	be	AUX
ijpds-3935	108	18	an	an	DET
ijpds-3935	108	19	area	area	NOUN
ijpds-3935	108	20	of	of	ADP
ijpds-3935	108	21	active	active	ADJ
ijpds-3935	108	22	research	research	NOUN
ijpds-3935	108	23	[	[	X
ijpds-3935	108	24	33	33	NUM
ijpds-3935	108	25	]	]	PUNCT
ijpds-3935	108	26	.	.	PUNCT
ijpds-3935	109	1	combating	combat	VERB
ijpds-3935	109	2	drug	drug	NOUN
ijpds-3935	109	3	resistance	resistance	NOUN
ijpds-3935	109	4	is	be	AUX
ijpds-3935	109	5	one	one	NUM
ijpds-3935	109	6	of	of	ADP
ijpds-3935	109	7	the	the	DET
ijpds-3935	109	8	main	main	ADJ
ijpds-3935	109	9	obstacles	obstacle	NOUN
ijpds-3935	109	10	in	in	ADP
ijpds-3935	109	11	the	the	DET
ijpds-3935	109	12	fight	fight	NOUN
ijpds-3935	109	13	against	against	ADP
ijpds-3935	109	14	cancer	cancer	NOUN
ijpds-3935	109	15	.	.	PUNCT
ijpds-3935	110	1	to	to	PART
ijpds-3935	110	2	increase	increase	VERB
ijpds-3935	110	3	the	the	DET
ijpds-3935	110	4	efficiency	efficiency	NOUN
ijpds-3935	110	5	of	of	ADP
ijpds-3935	110	6	chemotherapy	chemotherapy	NOUN
ijpds-3935	110	7	and	and	CCONJ
ijpds-3935	110	8	other	other	ADJ
ijpds-3935	110	9	cancer	cancer	NOUN
ijpds-3935	110	10	treatments	treatment	NOUN
ijpds-3935	110	11	,	,	PUNCT
ijpds-3935	110	12	researchers	researcher	NOUN
ijpds-3935	110	13	are	be	AUX
ijpds-3935	110	14	investigating	investigate	VERB
ijpds-3935	110	15	the	the	DET
ijpds-3935	110	16	potential	potential	NOUN
ijpds-3935	110	17	of	of	ADP
ijpds-3935	110	18	sirna	sirna	PROPN
ijpds-3935	110	19	-	-	PUNCT
ijpds-3935	110	20	based	base	VERB
ijpds-3935	110	21	therapeutics	therapeutic	NOUN
ijpds-3935	110	22	to	to	PART
ijpds-3935	110	23	target	target	VERB
ijpds-3935	110	24	genes	gene	NOUN
ijpds-3935	110	25	that	that	PRON
ijpds-3935	110	26	are	be	AUX
ijpds-3935	110	27	involved	involve	VERB
ijpds-3935	110	28	in	in	ADP
ijpds-3935	110	29	drug	drug	NOUN
ijpds-3935	110	30	resistance	resistance	NOUN
ijpds-3935	110	31	[	[	X
ijpds-3935	110	32	34	34	NUM
ijpds-3935	110	33	]	]	PUNCT
ijpds-3935	110	34	.	.	PUNCT
ijpds-3935	111	1	the	the	DET
ijpds-3935	111	2	development	development	NOUN
ijpds-3935	111	3	of	of	ADP
ijpds-3935	111	4	innovative	innovative	ADJ
ijpds-3935	111	5	delivery	delivery	NOUN
ijpds-3935	111	6	technologies	technology	NOUN
ijpds-3935	111	7	that	that	PRON
ijpds-3935	111	8	might	might	AUX
ijpds-3935	111	9	increase	increase	VERB
ijpds-3935	111	10	the	the	DET
ijpds-3935	111	11	effectiveness	effectiveness	NOUN
ijpds-3935	111	12	of	of	ADP
ijpds-3935	111	13	sirna	sirna	PROPN
ijpds-3935	111	14	distribution	distribution	NOUN
ijpds-3935	111	15	is	be	AUX
ijpds-3935	111	16	a	a	DET
ijpds-3935	111	17	key	key	ADJ
ijpds-3935	111	18	area	area	NOUN
ijpds-3935	111	19	of	of	ADP
ijpds-3935	111	20	scientific	scientific	ADJ
ijpds-3935	111	21	interest	interest	NOUN
ijpds-3935	111	22	.	.	PUNCT
ijpds-3935	112	1	to	to	PART
ijpds-3935	112	2	improve	improve	VERB
ijpds-3935	112	3	the	the	DET
ijpds-3935	112	4	transport	transport	NOUN
ijpds-3935	112	5	of	of	ADP
ijpds-3935	112	6	sirnas	sirna	NOUN
ijpds-3935	112	7	to	to	PART
ijpds-3935	112	8	target	target	VERB
ijpds-3935	112	9	cells	cell	NOUN
ijpds-3935	112	10	,	,	PUNCT
ijpds-3935	112	11	researchers	researcher	NOUN
ijpds-3935	112	12	are	be	AUX
ijpds-3935	112	13	experimenting	experiment	VERB
ijpds-3935	112	14	with	with	ADP
ijpds-3935	112	15	the	the	DET
ijpds-3935	112	16	use	use	NOUN
ijpds-3935	112	17	of	of	ADP
ijpds-3935	112	18	nanoparticles	nanoparticle	NOUN
ijpds-3935	112	19	,	,	PUNCT
ijpds-3935	112	20	liposomes	liposome	NOUN
ijpds-3935	112	21	,	,	PUNCT
ijpds-3935	112	22	and	and	CCONJ
ijpds-3935	112	23	other	other	ADJ
ijpds-3935	112	24	technologies	technology	NOUN
ijpds-3935	112	25	[	[	X
ijpds-3935	112	26	35	35	NUM
ijpds-3935	112	27	]	]	PUNCT
ijpds-3935	112	28	.	.	PUNCT
ijpds-3935	113	1	further	further	ADJ
ijpds-3935	113	2	clinical	clinical	ADJ
ijpds-3935	113	3	trials	trial	NOUN
ijpds-3935	113	4	are	be	AUX
ijpds-3935	113	5	required	require	VERB
ijpds-3935	113	6	to	to	PART
ijpds-3935	113	7	assess	assess	VERB
ijpds-3935	113	8	the	the	DET
ijpds-3935	113	9	security	security	NOUN
ijpds-3935	113	10	and	and	CCONJ
ijpds-3935	113	11	effectiveness	effectiveness	NOUN
ijpds-3935	113	12	of	of	ADP
ijpds-3935	113	13	sirna	sirna	PROPN
ijpds-3935	113	14	-	-	PUNCT
ijpds-3935	113	15	based	base	VERB
ijpds-3935	113	16	treatments	treatment	NOUN
ijpds-3935	113	17	for	for	ADP
ijpds-3935	113	18	the	the	DET
ijpds-3935	113	19	treatment	treatment	NOUN
ijpds-3935	113	20	of	of	ADP
ijpds-3935	113	21	cancer	cancer	NOUN
ijpds-3935	113	22	.	.	PUNCT
ijpds-3935	114	1	to	to	PART
ijpds-3935	114	2	maximize	maximize	VERB
ijpds-3935	114	3	the	the	DET
ijpds-3935	114	4	clinical	clinical	ADJ
ijpds-3935	114	5	translation	translation	NOUN
ijpds-3935	114	6	of	of	ADP
ijpds-3935	114	7	sirna	sirna	PROPN
ijpds-3935	114	8	-	-	PUNCT
ijpds-3935	114	9	based	base	VERB
ijpds-3935	114	10	therapeutics	therapeutic	NOUN
ijpds-3935	114	11	,	,	PUNCT
ijpds-3935	114	12	ongoing	ongoing	ADJ
ijpds-3935	114	13	research	research	NOUN
ijpds-3935	114	14	,	,	PUNCT
ijpds-3935	114	15	and	and	CCONJ
ijpds-3935	114	16	development	development	NOUN
ijpds-3935	114	17	are	be	AUX
ijpds-3935	114	18	required	require	VERB
ijpds-3935	114	19	[	[	X
ijpds-3935	114	20	36	36	NUM
ijpds-3935	114	21	]	]	PUNCT
ijpds-3935	114	22	.	.	PUNCT
ijpds-3935	115	1	overall	overall	ADV
ijpds-3935	115	2	,	,	PUNCT
ijpds-3935	115	3	the	the	DET
ijpds-3935	115	4	field	field	NOUN
ijpds-3935	115	5	of	of	ADP
ijpds-3935	115	6	sirna	sirna	PROPN
ijpds-3935	115	7	-	-	PUNCT
ijpds-3935	115	8	mediated	mediate	VERB
ijpds-3935	115	9	silencing	silencing	NOUN
ijpds-3935	115	10	of	of	ADP
ijpds-3935	115	11	oncogenes	oncogene	NOUN
ijpds-3935	115	12	for	for	ADP
ijpds-3935	115	13	cancer	cancer	NOUN
ijpds-3935	115	14	therapy	therapy	NOUN
ijpds-3935	115	15	is	be	AUX
ijpds-3935	115	16	rapidly	rapidly	ADV
ijpds-3935	115	17	advancing	advance	VERB
ijpds-3935	115	18	,	,	PUNCT
ijpds-3935	115	19	and	and	CCONJ
ijpds-3935	115	20	there	there	PRON
ijpds-3935	115	21	is	be	VERB
ijpds-3935	115	22	great	great	ADJ
ijpds-3935	115	23	potential	potential	NOUN
ijpds-3935	115	24	for	for	SCONJ
ijpds-3935	115	25	these	these	DET
ijpds-3935	115	26	therapies	therapy	NOUN
ijpds-3935	115	27	to	to	PART
ijpds-3935	115	28	significantly	significantly	ADV
ijpds-3935	115	29	improve	improve	VERB
ijpds-3935	115	30	cancer	cancer	NOUN
ijpds-3935	115	31	treatment	treatment	NOUN
ijpds-3935	115	32	.	.	PUNCT
ijpds-3935	116	1	with	with	ADP
ijpds-3935	116	2	continued	continued	ADJ
ijpds-3935	116	3	research	research	NOUN
ijpds-3935	116	4	and	and	CCONJ
ijpds-3935	116	5	development	development	NOUN
ijpds-3935	116	6	,	,	PUNCT
ijpds-3935	116	7	it	it	PRON
ijpds-3935	116	8	is	be	AUX
ijpds-3935	116	9	hoped	hope	VERB
ijpds-3935	116	10	that	that	SCONJ
ijpds-3935	116	11	sirna	sirna	PROPN
ijpds-3935	116	12	-	-	PUNCT
ijpds-3935	116	13	based	base	VERB
ijpds-3935	116	14	therapies	therapy	NOUN
ijpds-3935	116	15	eventually	eventually	ADV
ijpds-3935	116	16	become	become	VERB
ijpds-3935	116	17	integral	integral	ADJ
ijpds-3935	116	18	to	to	ADP
ijpds-3935	116	19	cancer	cancer	NOUN
ijpds-3935	116	20	treatment	treatment	NOUN
ijpds-3935	116	21	.	.	PUNCT
ijpds-3935	117	1	advantages	advantage	NOUN
ijpds-3935	117	2	of	of	ADP
ijpds-3935	117	3	sirna	sirna	PROPN
ijpds-3935	117	4	-	-	PUNCT
ijpds-3935	117	5	based	base	VERB
ijpds-3935	117	6	therapies	therapy	NOUN
ijpds-3935	117	7	for	for	ADP
ijpds-3935	117	8	cancer	cancer	NOUN
ijpds-3935	117	9	treatment	treatment	NOUN
ijpds-3935	117	10	very	very	ADV
ijpds-3935	117	11	targeted	targeted	ADJ
ijpds-3935	117	12	and	and	CCONJ
ijpds-3935	117	13	precise	precise	ADJ
ijpds-3935	117	14	sirna	sirna	PROPN
ijpds-3935	117	15	-	-	PUNCT
ijpds-3935	117	16	based	base	VERB
ijpds-3935	117	17	therapeutics	therapeutic	NOUN
ijpds-3935	117	18	can	can	AUX
ijpds-3935	117	19	be	be	AUX
ijpds-3935	117	20	created	create	VERB
ijpds-3935	117	21	to	to	PART
ijpds-3935	117	22	target	target	VERB
ijpds-3935	117	23	particular	particular	ADJ
ijpds-3935	117	24	genes	gene	NOUN
ijpds-3935	117	25	that	that	PRON
ijpds-3935	117	26	contribute	contribute	VERB
ijpds-3935	117	27	to	to	ADP
ijpds-3935	117	28	the	the	DET
ijpds-3935	117	29	development	development	NOUN
ijpds-3935	117	30	of	of	ADP
ijpds-3935	117	31	cancer	cancer	NOUN
ijpds-3935	118	1	[	[	X
ijpds-3935	118	2	2	2	NUM
ijpds-3935	118	3	]	]	PUNCT
ijpds-3935	118	4	.	.	PUNCT
ijpds-3935	119	1	sirna	sirna	PROPN
ijpds-3935	119	2	-	-	PUNCT
ijpds-3935	119	3	based	base	VERB
ijpds-3935	119	4	therapies	therapy	NOUN
ijpds-3935	119	5	have	have	VERB
ijpds-3935	119	6	the	the	DET
ijpds-3935	119	7	potential	potential	NOUN
ijpds-3935	119	8	to	to	PART
ijpds-3935	119	9	be	be	AUX
ijpds-3935	119	10	utilized	utilize	VERB
ijpds-3935	119	11	in	in	ADP
ijpds-3935	119	12	conjunction	conjunction	NOUN
ijpds-3935	119	13	with	with	ADP
ijpds-3935	119	14	other	other	ADJ
ijpds-3935	119	15	cancer	cancer	NOUN
ijpds-3935	119	16	treatments	treatment	NOUN
ijpds-3935	119	17	like	like	ADP
ijpds-3935	119	18	chemotherapy	chemotherapy	NOUN
ijpds-3935	119	19	or	or	CCONJ
ijpds-3935	119	20	immunotherapy	immunotherapy	NOUN
ijpds-3935	119	21	to	to	PART
ijpds-3935	119	22	increase	increase	VERB
ijpds-3935	119	23	the	the	DET
ijpds-3935	119	24	efficacy	efficacy	NOUN
ijpds-3935	119	25	of	of	ADP
ijpds-3935	119	26	both	both	PRON
ijpds-3935	119	27	[	[	X
ijpds-3935	119	28	37	37	NUM
ijpds-3935	119	29	]	]	PUNCT
ijpds-3935	119	30	.	.	PUNCT
ijpds-3935	120	1	sirna	sirna	PROPN
ijpds-3935	120	2	-	-	PUNCT
ijpds-3935	120	3	based	base	VERB
ijpds-3935	120	4	cancer	cancer	NOUN
ijpds-3935	120	5	therapies	therapy	NOUN
ijpds-3935	120	6	can	can	AUX
ijpds-3935	120	7	be	be	AUX
ijpds-3935	120	8	created	create	VERB
ijpds-3935	120	9	to	to	PART
ijpds-3935	120	10	target	target	VERB
ijpds-3935	120	11	a	a	DET
ijpds-3935	120	12	multitude	multitude	NOUN
ijpds-3935	120	13	of	of	ADP
ijpds-3935	120	14	genes	gene	NOUN
ijpds-3935	120	15	,	,	PUNCT
ijpds-3935	120	16	including	include	VERB
ijpds-3935	120	17	oncogenes	oncogene	NOUN
ijpds-3935	120	18	,	,	PUNCT
ijpds-3935	120	19	shanbhag	shanbhag	NOUN
ijpds-3935	120	20	et	et	PROPN
ijpds-3935	120	21	al	al	PROPN
ijpds-3935	120	22	.	.	PUNCT
ijpds-3935	121	1	cancer	cancer	NOUN
ijpds-3935	121	2	therapy	therapy	NOUN
ijpds-3935	121	3	:	:	PUNCT
ijpds-3935	121	4	an	an	DET
ijpds-3935	121	5	overview	overview	NOUN
ijpds-3935	121	6	of	of	ADP
ijpds-3935	121	7	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	121	8	strategies	strategy	NOUN
ijpds-3935	121	9	vol	vol	VERB
ijpds-3935	121	10	2|	2|	NUM
ijpds-3935	121	11	issue	issue	NOUN
ijpds-3935	121	12	2	2	NUM
ijpds-3935	121	13	|	|	ADV
ijpds-3935	121	14	apr	apr	ADV
ijpds-3935	121	15	–	–	PUNCT
ijpds-3935	121	16	jun	jun	PROPN
ijpds-3935	121	17	2023	2023	NUM
ijpds-3935	121	18	indian	indian	PROPN
ijpds-3935	121	19	j	j	PROPN
ijpds-3935	121	20	pharm	pharm	PROPN
ijpds-3935	121	21	drug	drug	PROPN
ijpds-3935	121	22	studies	study	NOUN
ijpds-3935	121	23	|	|	ADV
ijpds-3935	121	24	67	67	NUM
ijpds-3935	121	25	tumor	tumor	NOUN
ijpds-3935	121	26	suppressors	suppressor	NOUN
ijpds-3935	121	27	,	,	PUNCT
ijpds-3935	121	28	and	and	CCONJ
ijpds-3935	121	29	genes	gene	NOUN
ijpds-3935	121	30	involved	involve	VERB
ijpds-3935	121	31	in	in	ADP
ijpds-3935	121	32	angiogenesis	angiogenesis	NOUN
ijpds-3935	121	33	and	and	CCONJ
ijpds-3935	121	34	metastasis	metastasis	NOUN
ijpds-3935	121	35	,	,	PUNCT
ijpds-3935	121	36	that	that	PRON
ijpds-3935	121	37	are	be	AUX
ijpds-3935	121	38	implicated	implicate	VERB
ijpds-3935	121	39	in	in	ADP
ijpds-3935	121	40	the	the	DET
ijpds-3935	121	41	development	development	NOUN
ijpds-3935	121	42	of	of	ADP
ijpds-3935	121	43	cancer	cancer	NOUN
ijpds-3935	121	44	[	[	X
ijpds-3935	121	45	38	38	NUM
ijpds-3935	121	46	]	]	PUNCT
ijpds-3935	121	47	.	.	PUNCT
ijpds-3935	122	1	sirna	sirna	PROPN
ijpds-3935	122	2	-	-	PUNCT
ijpds-3935	122	3	based	base	VERB
ijpds-3935	122	4	therapies	therapy	NOUN
ijpds-3935	122	5	have	have	VERB
ijpds-3935	122	6	the	the	DET
ijpds-3935	122	7	potential	potential	NOUN
ijpds-3935	122	8	to	to	PART
ijpds-3935	122	9	advance	advance	VERB
ijpds-3935	122	10	personalized	personalized	ADJ
ijpds-3935	122	11	medicine	medicine	NOUN
ijpds-3935	122	12	since	since	SCONJ
ijpds-3935	122	13	they	they	PRON
ijpds-3935	122	14	can	can	AUX
ijpds-3935	122	15	be	be	AUX
ijpds-3935	122	16	tailored	tailor	VERB
ijpds-3935	122	17	for	for	ADP
ijpds-3935	122	18	specific	specific	ADJ
ijpds-3935	122	19	patients	patient	NOUN
ijpds-3935	122	20	based	base	VERB
ijpds-3935	122	21	on	on	ADP
ijpds-3935	122	22	their	their	PRON
ijpds-3935	122	23	genetic	genetic	ADJ
ijpds-3935	122	24	profiles	profile	NOUN
ijpds-3935	122	25	,	,	PUNCT
ijpds-3935	122	26	which	which	PRON
ijpds-3935	122	27	may	may	AUX
ijpds-3935	122	28	result	result	VERB
ijpds-3935	122	29	in	in	ADP
ijpds-3935	122	30	more	more	ADV
ijpds-3935	122	31	efficient	efficient	ADJ
ijpds-3935	122	32	and	and	CCONJ
ijpds-3935	122	33	specialized	specialized	ADJ
ijpds-3935	122	34	cancer	cancer	NOUN
ijpds-3935	122	35	treatment	treatment	NOUN
ijpds-3935	122	36	[	[	X
ijpds-3935	122	37	39	39	NUM
ijpds-3935	122	38	]	]	PUNCT
ijpds-3935	122	39	.	.	PUNCT
ijpds-3935	123	1	sirnabased	sirnabase	VERB
ijpds-3935	123	2	therapies	therapy	NOUN
ijpds-3935	123	3	are	be	AUX
ijpds-3935	123	4	highly	highly	ADV
ijpds-3935	123	5	specific	specific	ADJ
ijpds-3935	123	6	,	,	PUNCT
ijpds-3935	123	7	which	which	PRON
ijpds-3935	123	8	means	mean	VERB
ijpds-3935	123	9	that	that	SCONJ
ijpds-3935	123	10	they	they	PRON
ijpds-3935	123	11	have	have	VERB
ijpds-3935	123	12	the	the	DET
ijpds-3935	123	13	potential	potential	NOUN
ijpds-3935	123	14	to	to	PART
ijpds-3935	123	15	be	be	AUX
ijpds-3935	123	16	less	less	ADV
ijpds-3935	123	17	toxic	toxic	ADJ
ijpds-3935	123	18	than	than	ADP
ijpds-3935	123	19	traditional	traditional	ADJ
ijpds-3935	123	20	cancer	cancer	NOUN
ijpds-3935	123	21	treatments	treatment	NOUN
ijpds-3935	123	22	,	,	PUNCT
ijpds-3935	123	23	which	which	PRON
ijpds-3935	123	24	can	can	AUX
ijpds-3935	123	25	have	have	VERB
ijpds-3935	123	26	significant	significant	ADJ
ijpds-3935	123	27	side	side	NOUN
ijpds-3935	123	28	effects	effect	NOUN
ijpds-3935	123	29	[	[	X
ijpds-3935	123	30	40	40	NUM
ijpds-3935	123	31	]	]	PUNCT
ijpds-3935	123	32	.	.	PUNCT
ijpds-3935	124	1	limitations	limitation	NOUN
ijpds-3935	124	2	of	of	ADP
ijpds-3935	124	3	sirna	sirna	PROPN
ijpds-3935	124	4	-	-	PUNCT
ijpds-3935	124	5	based	base	VERB
ijpds-3935	124	6	therapies	therapy	NOUN
ijpds-3935	124	7	for	for	ADP
ijpds-3935	124	8	cancer	cancer	NOUN
ijpds-3935	124	9	treatment	treatment	NOUN
ijpds-3935	124	10	include	include	VERB
ijpds-3935	124	11	sirnas	sirna	NOUN
ijpds-3935	124	12	are	be	AUX
ijpds-3935	124	13	substantial	substantial	ADJ
ijpds-3935	124	14	,	,	PUNCT
ijpds-3935	124	15	negatively	negatively	ADV
ijpds-3935	124	16	charged	charge	VERB
ijpds-3935	124	17	molecules	molecule	NOUN
ijpds-3935	124	18	that	that	PRON
ijpds-3935	124	19	are	be	AUX
ijpds-3935	124	20	difficult	difficult	ADJ
ijpds-3935	124	21	to	to	PART
ijpds-3935	124	22	get	get	VERB
ijpds-3935	124	23	through	through	ADP
ijpds-3935	124	24	cell	cell	NOUN
ijpds-3935	124	25	membranes	membrane	NOUN
ijpds-3935	124	26	.	.	PUNCT
ijpds-3935	125	1	the	the	DET
ijpds-3935	125	2	creation	creation	NOUN
ijpds-3935	125	3	of	of	ADP
ijpds-3935	125	4	effective	effective	ADJ
ijpds-3935	125	5	and	and	CCONJ
ijpds-3935	125	6	secure	secure	ADJ
ijpds-3935	125	7	sirna	sirna	PROPN
ijpds-3935	125	8	delivery	delivery	NOUN
ijpds-3935	125	9	methods	method	NOUN
ijpds-3935	125	10	is	be	AUX
ijpds-3935	125	11	a	a	DET
ijpds-3935	125	12	difficult	difficult	ADJ
ijpds-3935	125	13	task	task	NOUN
ijpds-3935	125	14	[	[	X
ijpds-3935	125	15	41	41	NUM
ijpds-3935	125	16	]	]	PUNCT
ijpds-3935	125	17	.	.	PUNCT
ijpds-3935	126	1	possibility	possibility	NOUN
ijpds-3935	126	2	for	for	ADP
ijpds-3935	126	3	harmful	harmful	ADJ
ijpds-3935	126	4	off	off	ADP
ijpds-3935	126	5	-	-	PUNCT
ijpds-3935	126	6	target	target	NOUN
ijpds-3935	126	7	effects	effect	NOUN
ijpds-3935	126	8	:	:	PUNCT
ijpds-3935	126	9	sirna	sirna	PROPN
ijpds-3935	126	10	-	-	PUNCT
ijpds-3935	126	11	mediated	mediate	VERB
ijpds-3935	126	12	gene	gene	NOUN
ijpds-3935	126	13	silencing	silence	VERB
ijpds-3935	126	14	may	may	AUX
ijpds-3935	126	15	have	have	VERB
ijpds-3935	126	16	unintended	unintended	ADJ
ijpds-3935	126	17	consequences	consequence	NOUN
ijpds-3935	126	18	on	on	ADP
ijpds-3935	126	19	genes	gene	NOUN
ijpds-3935	126	20	that	that	PRON
ijpds-3935	126	21	are	be	AUX
ijpds-3935	126	22	not	not	PART
ijpds-3935	126	23	intended	intend	VERB
ijpds-3935	126	24	targets	target	NOUN
ijpds-3935	126	25	[	[	X
ijpds-3935	126	26	42	42	NUM
ijpds-3935	126	27	]	]	PUNCT
ijpds-3935	126	28	.	.	PUNCT
ijpds-3935	127	1	sirna	sirna	PROPN
ijpds-3935	127	2	-	-	PUNCT
ijpds-3935	127	3	based	base	VERB
ijpds-3935	127	4	medicines	medicine	NOUN
ijpds-3935	127	5	still	still	ADV
ijpds-3935	127	6	have	have	VERB
ijpds-3935	127	7	a	a	DET
ijpds-3935	127	8	high	high	ADJ
ijpds-3935	127	9	production	production	NOUN
ijpds-3935	127	10	cost	cost	NOUN
ijpds-3935	127	11	,	,	PUNCT
ijpds-3935	127	12	and	and	CCONJ
ijpds-3935	127	13	patients	patient	NOUN
ijpds-3935	127	14	have	have	VERB
ijpds-3935	127	15	less	less	ADJ
ijpds-3935	127	16	access	access	NOUN
ijpds-3935	127	17	to	to	ADP
ijpds-3935	127	18	them	they	PRON
ijpds-3935	127	19	[	[	X
ijpds-3935	127	20	43	43	NUM
ijpds-3935	127	21	]	]	PUNCT
ijpds-3935	127	22	.	.	PUNCT
ijpds-3935	128	1	sirnas	sirna	NOUN
ijpds-3935	128	2	have	have	VERB
ijpds-3935	128	3	a	a	DET
ijpds-3935	128	4	short	short	ADJ
ijpds-3935	128	5	bloodstream	bloodstream	NOUN
ijpds-3935	128	6	half	half	ADJ
ijpds-3935	128	7	-	-	PUNCT
ijpds-3935	128	8	life	life	NOUN
ijpds-3935	128	9	;	;	PUNCT
ijpds-3935	128	10	regular	regular	ADJ
ijpds-3935	128	11	dosing	dosing	NOUN
ijpds-3935	128	12	may	may	AUX
ijpds-3935	128	13	be	be	AUX
ijpds-3935	128	14	required	require	VERB
ijpds-3935	128	15	[	[	X
ijpds-3935	128	16	44	44	NUM
ijpds-3935	128	17	]	]	PUNCT
ijpds-3935	128	18	.	.	PUNCT
ijpds-3935	129	1	only	only	ADV
ijpds-3935	129	2	a	a	DET
ijpds-3935	129	3	small	small	ADJ
ijpds-3935	129	4	number	number	NOUN
ijpds-3935	129	5	of	of	ADP
ijpds-3935	129	6	sirnabased	sirnabase	VERB
ijpds-3935	129	7	cancer	cancer	NOUN
ijpds-3935	129	8	medicines	medicine	NOUN
ijpds-3935	129	9	have	have	AUX
ijpds-3935	129	10	moved	move	VERB
ijpds-3935	129	11	to	to	ADP
ijpds-3935	129	12	clinical	clinical	ADJ
ijpds-3935	129	13	trials	trial	NOUN
ijpds-3935	129	14	,	,	PUNCT
ijpds-3935	129	15	and	and	CCONJ
ijpds-3935	129	16	none	none	NOUN
ijpds-3935	129	17	have	have	AUX
ijpds-3935	129	18	received	receive	VERB
ijpds-3935	129	19	approval	approval	NOUN
ijpds-3935	129	20	for	for	ADP
ijpds-3935	129	21	use	use	NOUN
ijpds-3935	129	22	in	in	ADP
ijpds-3935	129	23	humans	human	NOUN
ijpds-3935	129	24	despite	despite	SCONJ
ijpds-3935	129	25	extensive	extensive	ADJ
ijpds-3935	129	26	preclinical	preclinical	ADJ
ijpds-3935	129	27	research	research	NOUN
ijpds-3935	130	1	[	[	X
ijpds-3935	130	2	4	4	NUM
ijpds-3935	130	3	]	]	PUNCT
ijpds-3935	130	4	.	.	PUNCT
ijpds-3935	131	1	overall	overall	ADJ
ijpds-3935	131	2	,	,	PUNCT
ijpds-3935	131	3	while	while	SCONJ
ijpds-3935	131	4	sirna	sirna	PROPN
ijpds-3935	131	5	-	-	PUNCT
ijpds-3935	131	6	based	base	VERB
ijpds-3935	131	7	therapies	therapy	NOUN
ijpds-3935	131	8	hold	hold	VERB
ijpds-3935	131	9	great	great	ADJ
ijpds-3935	131	10	potential	potential	NOUN
ijpds-3935	131	11	for	for	ADP
ijpds-3935	131	12	improving	improve	VERB
ijpds-3935	131	13	cancer	cancer	NOUN
ijpds-3935	131	14	treatment	treatment	NOUN
ijpds-3935	131	15	,	,	PUNCT
ijpds-3935	131	16	several	several	ADJ
ijpds-3935	131	17	challenges	challenge	NOUN
ijpds-3935	131	18	still	still	ADV
ijpds-3935	131	19	need	need	VERB
ijpds-3935	131	20	to	to	PART
ijpds-3935	131	21	be	be	AUX
ijpds-3935	131	22	addressed	address	VERB
ijpds-3935	131	23	before	before	SCONJ
ijpds-3935	131	24	they	they	PRON
ijpds-3935	131	25	become	become	AUX
ijpds-3935	131	26	widely	widely	ADV
ijpds-3935	131	27	used	use	VERB
ijpds-3935	131	28	in	in	ADP
ijpds-3935	131	29	clinical	clinical	ADJ
ijpds-3935	131	30	settings	setting	NOUN
ijpds-3935	131	31	.	.	PUNCT
ijpds-3935	132	1	ongoing	ongoing	ADJ
ijpds-3935	132	2	research	research	NOUN
ijpds-3935	132	3	and	and	CCONJ
ijpds-3935	132	4	development	development	NOUN
ijpds-3935	132	5	are	be	AUX
ijpds-3935	132	6	necessary	necessary	ADJ
ijpds-3935	132	7	to	to	PART
ijpds-3935	132	8	optimize	optimize	VERB
ijpds-3935	132	9	the	the	DET
ijpds-3935	132	10	efficacy	efficacy	NOUN
ijpds-3935	132	11	,	,	PUNCT
ijpds-3935	132	12	safety	safety	NOUN
ijpds-3935	132	13	,	,	PUNCT
ijpds-3935	132	14	and	and	CCONJ
ijpds-3935	132	15	delivery	delivery	NOUN
ijpds-3935	132	16	of	of	ADP
ijpds-3935	132	17	sirna	sirna	PROPN
ijpds-3935	132	18	-	-	PUNCT
ijpds-3935	132	19	based	base	VERB
ijpds-3935	132	20	therapies	therapy	NOUN
ijpds-3935	132	21	.	.	PUNCT
ijpds-3935	133	1	conclusion	conclusion	NOUN
ijpds-3935	133	2	sirna	sirna	PROPN
ijpds-3935	133	3	-	-	PUNCT
ijpds-3935	133	4	mediated	mediate	VERB
ijpds-3935	133	5	cancer	cancer	NOUN
ijpds-3935	133	6	therapy	therapy	NOUN
ijpds-3935	133	7	has	have	VERB
ijpds-3935	133	8	great	great	ADJ
ijpds-3935	133	9	potential	potential	NOUN
ijpds-3935	133	10	for	for	ADP
ijpds-3935	133	11	highly	highly	ADV
ijpds-3935	133	12	specific	specific	ADJ
ijpds-3935	133	13	and	and	CCONJ
ijpds-3935	133	14	effective	effective	ADJ
ijpds-3935	133	15	treatment	treatment	NOUN
ijpds-3935	133	16	.	.	PUNCT
ijpds-3935	134	1	however	however	ADV
ijpds-3935	134	2	,	,	PUNCT
ijpds-3935	134	3	efficient	efficient	ADJ
ijpds-3935	134	4	and	and	CCONJ
ijpds-3935	134	5	safe	safe	ADJ
ijpds-3935	134	6	delivery	delivery	NOUN
ijpds-3935	134	7	systems	system	NOUN
ijpds-3935	134	8	need	need	VERB
ijpds-3935	134	9	to	to	PART
ijpds-3935	134	10	be	be	AUX
ijpds-3935	134	11	developed	develop	VERB
ijpds-3935	134	12	,	,	PUNCT
ijpds-3935	134	13	and	and	CCONJ
ijpds-3935	134	14	more	more	ADV
ijpds-3935	134	15	clinical	clinical	ADJ
ijpds-3935	134	16	trials	trial	NOUN
ijpds-3935	134	17	are	be	AUX
ijpds-3935	134	18	required	require	VERB
ijpds-3935	134	19	for	for	ADP
ijpds-3935	134	20	the	the	DET
ijpds-3935	134	21	evaluation	evaluation	NOUN
ijpds-3935	134	22	of	of	ADP
ijpds-3935	134	23	safety	safety	NOUN
ijpds-3935	134	24	and	and	CCONJ
ijpds-3935	134	25	efficacy	efficacy	NOUN
ijpds-3935	134	26	.	.	PUNCT
ijpds-3935	135	1	researchers	researcher	NOUN
ijpds-3935	135	2	are	be	AUX
ijpds-3935	135	3	working	work	VERB
ijpds-3935	135	4	on	on	ADP
ijpds-3935	135	5	developing	develop	VERB
ijpds-3935	135	6	new	new	ADJ
ijpds-3935	135	7	delivery	delivery	NOUN
ijpds-3935	135	8	systems	system	NOUN
ijpds-3935	135	9	,	,	PUNCT
ijpds-3935	135	10	personalized	personalize	VERB
ijpds-3935	135	11	medicine	medicine	NOUN
ijpds-3935	135	12	approaches	approach	NOUN
ijpds-3935	135	13	,	,	PUNCT
ijpds-3935	135	14	and	and	CCONJ
ijpds-3935	135	15	combination	combination	NOUN
ijpds-3935	135	16	therapies	therapy	NOUN
ijpds-3935	135	17	to	to	PART
ijpds-3935	135	18	overcome	overcome	VERB
ijpds-3935	135	19	these	these	DET
ijpds-3935	135	20	challenges	challenge	NOUN
ijpds-3935	135	21	.	.	PUNCT
ijpds-3935	136	1	continued	continue	VERB
ijpds-3935	136	2	development	development	NOUN
ijpds-3935	136	3	of	of	ADP
ijpds-3935	136	4	sirna	sirna	PROPN
ijpds-3935	136	5	-	-	PUNCT
ijpds-3935	136	6	based	base	VERB
ijpds-3935	136	7	therapies	therapy	NOUN
ijpds-3935	136	8	could	could	AUX
ijpds-3935	136	9	revolutionize	revolutionize	VERB
ijpds-3935	136	10	cancer	cancer	NOUN
ijpds-3935	136	11	treatment	treatment	NOUN
ijpds-3935	136	12	,	,	PUNCT
ijpds-3935	136	13	providing	provide	VERB
ijpds-3935	136	14	patients	patient	NOUN
ijpds-3935	136	15	with	with	ADP
ijpds-3935	136	16	targeted	targeted	ADJ
ijpds-3935	136	17	and	and	CCONJ
ijpds-3935	136	18	effective	effective	ADJ
ijpds-3935	136	19	options	option	NOUN
ijpds-3935	136	20	.	.	PUNCT
ijpds-3935	137	1	references	reference	NOUN
ijpds-3935	137	2	1	1	NUM
ijpds-3935	137	3	.	.	PUNCT
ijpds-3935	137	4	castanotto	castanotto	PROPN
ijpds-3935	137	5	d	d	PROPN
ijpds-3935	137	6	,	,	PUNCT
ijpds-3935	137	7	rossi	rossi	PROPN
ijpds-3935	137	8	jj	jj	PROPN
ijpds-3935	137	9	.	.	PUNCT
ijpds-3935	138	1	the	the	DET
ijpds-3935	138	2	promises	promise	NOUN
ijpds-3935	138	3	and	and	CCONJ
ijpds-3935	138	4	pitfalls	pitfall	NOUN
ijpds-3935	138	5	of	of	ADP
ijpds-3935	138	6	rnainterference	rnainterference	NOUN
ijpds-3935	138	7	-	-	PUNCT
ijpds-3935	138	8	based	base	VERB
ijpds-3935	138	9	therapeutics	therapeutic	NOUN
ijpds-3935	138	10	.	.	PUNCT
ijpds-3935	139	1	nature	nature	NOUN
ijpds-3935	139	2	.	.	PUNCT
ijpds-3935	140	1	2009	2009	NUM
ijpds-3935	140	2	jan	jan	NOUN
ijpds-3935	140	3	22;457(7228):426	22;457(7228):426	NUM
ijpds-3935	140	4	-	-	SYM
ijpds-3935	140	5	33	33	NUM
ijpds-3935	140	6	.	.	NOUN
ijpds-3935	140	7	2	2	NUM
ijpds-3935	140	8	.	.	X
ijpds-3935	140	9	guo	guo	PROPN
ijpds-3935	140	10	w	w	PROPN
ijpds-3935	140	11	,	,	PUNCT
ijpds-3935	140	12	chen	chen	PROPN
ijpds-3935	140	13	w	w	PROPN
ijpds-3935	140	14	,	,	PUNCT
ijpds-3935	140	15	yu	yu	PROPN
ijpds-3935	140	16	w	w	PROPN
ijpds-3935	140	17	,	,	PUNCT
ijpds-3935	140	18	et	et	PROPN
ijpds-3935	140	19	al	al	PROPN
ijpds-3935	140	20	.	.	PROPN
ijpds-3935	141	1	small	small	ADJ
ijpds-3935	141	2	interfering	interfere	VERB
ijpds-3935	141	3	rna	rna	NOUN
ijpds-3935	141	4	-	-	PUNCT
ijpds-3935	141	5	based	base	VERB
ijpds-3935	141	6	molecular	molecular	ADJ
ijpds-3935	141	7	therapy	therapy	NOUN
ijpds-3935	141	8	of	of	ADP
ijpds-3935	141	9	cancers	cancer	NOUN
ijpds-3935	141	10	.	.	PUNCT
ijpds-3935	142	1	chinese	chinese	ADJ
ijpds-3935	142	2	journal	journal	PROPN
ijpds-3935	142	3	of	of	ADP
ijpds-3935	142	4	cancer	cancer	NOUN
ijpds-3935	142	5	.	.	PUNCT
ijpds-3935	143	1	2013	2013	NUM
ijpds-3935	143	2	sep	sep	NOUN
ijpds-3935	143	3	5;32(9):488–93	5;32(9):488–93	NUM
ijpds-3935	143	4	.	.	PUNCT
ijpds-3935	144	1	3	3	X
ijpds-3935	144	2	.	.	X
ijpds-3935	144	3	wang	wang	PROPN
ijpds-3935	144	4	x	x	PROPN
ijpds-3935	144	5	,	,	PUNCT
ijpds-3935	144	6	yang	yang	PROPN
ijpds-3935	144	7	l	l	PROPN
ijpds-3935	144	8	,	,	PUNCT
ijpds-3935	144	9	chen	chen	PROPN
ijpds-3935	144	10	z	z	PROPN
ijpds-3935	144	11	,	,	PUNCT
ijpds-3935	144	12	et	et	PROPN
ijpds-3935	144	13	al	al	PROPN
ijpds-3935	144	14	.	.	PUNCT
ijpds-3935	144	15	application	application	NOUN
ijpds-3935	144	16	of	of	ADP
ijpds-3935	144	17	nanotechnology	nanotechnology	NOUN
ijpds-3935	144	18	in	in	ADP
ijpds-3935	144	19	cancer	cancer	NOUN
ijpds-3935	144	20	therapy	therapy	NOUN
ijpds-3935	144	21	and	and	CCONJ
ijpds-3935	144	22	imaging	imaging	NOUN
ijpds-3935	144	23	.	.	PUNCT
ijpds-3935	145	1	ca	can	AUX
ijpds-3935	145	2	:	:	PUNCT
ijpds-3935	145	3	a	a	DET
ijpds-3935	145	4	cancer	cancer	NOUN
ijpds-3935	145	5	journal	journal	NOUN
ijpds-3935	145	6	for	for	ADP
ijpds-3935	145	7	clinicians	clinician	NOUN
ijpds-3935	145	8	.	.	PUNCT
ijpds-3935	146	1	2008	2008	NUM
ijpds-3935	146	2	mar;58(2):97	mar;58(2):97	PROPN
ijpds-3935	146	3	-	-	PROPN
ijpds-3935	146	4	110	110	NUM
ijpds-3935	146	5	.	.	PUNCT
ijpds-3935	146	6	4	4	NUM
ijpds-3935	146	7	.	.	X
ijpds-3935	146	8	zuckerman	zuckerman	PROPN
ijpds-3935	146	9	je	je	PROPN
ijpds-3935	146	10	,	,	PUNCT
ijpds-3935	146	11	davis	davis	PROPN
ijpds-3935	146	12	me	i	PRON
ijpds-3935	146	13	.	.	PUNCT
ijpds-3935	147	1	clinical	clinical	ADJ
ijpds-3935	147	2	experiences	experience	NOUN
ijpds-3935	147	3	with	with	ADP
ijpds-3935	147	4	systemically	systemically	ADV
ijpds-3935	147	5	administered	administer	VERB
ijpds-3935	147	6	sirna	sirna	PROPN
ijpds-3935	147	7	-	-	PUNCT
ijpds-3935	147	8	based	base	VERB
ijpds-3935	147	9	therapeutics	therapeutic	NOUN
ijpds-3935	147	10	in	in	ADP
ijpds-3935	147	11	cancer	cancer	NOUN
ijpds-3935	147	12	.	.	PUNCT
ijpds-3935	148	1	nature	nature	NOUN
ijpds-3935	148	2	reviews	review	VERB
ijpds-3935	148	3	drug	drug	NOUN
ijpds-3935	148	4	discovery	discovery	NOUN
ijpds-3935	148	5	.	.	PUNCT
ijpds-3935	149	1	2015	2015	NUM
ijpds-3935	149	2	dec;14(12):843	dec;14(12):843	PROPN
ijpds-3935	149	3	-	-	PUNCT
ijpds-3935	149	4	56	56	NUM
ijpds-3935	149	5	.	.	NOUN
ijpds-3935	149	6	5	5	NUM
ijpds-3935	149	7	.	.	NOUN
ijpds-3935	149	8	ozpolat	ozpolat	PROPN
ijpds-3935	149	9	b	b	PROPN
ijpds-3935	149	10	,	,	PUNCT
ijpds-3935	149	11	sood	sood	PROPN
ijpds-3935	149	12	ak	ak	PROPN
ijpds-3935	149	13	,	,	PUNCT
ijpds-3935	149	14	lopez	lopez	NOUN
ijpds-3935	149	15	-	-	PUNCT
ijpds-3935	149	16	berestein	berestein	PROPN
ijpds-3935	149	17	g.	g.	PROPN
ijpds-3935	149	18	liposomal	liposomal	PROPN
ijpds-3935	149	19	sirna	sirna	PROPN
ijpds-3935	149	20	nanocarriers	nanocarrier	VERB
ijpds-3935	149	21	for	for	ADP
ijpds-3935	149	22	cancer	cancer	NOUN
ijpds-3935	149	23	therapy	therapy	NOUN
ijpds-3935	149	24	.	.	PUNCT
ijpds-3935	150	1	advanced	advanced	ADJ
ijpds-3935	150	2	drug	drug	NOUN
ijpds-3935	150	3	delivery	delivery	NOUN
ijpds-3935	150	4	reviews	review	NOUN
ijpds-3935	150	5	.	.	PUNCT
ijpds-3935	151	1	2014	2014	NUM
ijpds-3935	151	2	feb	feb	NOUN
ijpds-3935	151	3	1	1	NUM
ijpds-3935	151	4	;	;	PUNCT
ijpds-3935	151	5	66:110	66:110	PROPN
ijpds-3935	151	6	-	-	SYM
ijpds-3935	151	7	6	6	NUM
ijpds-3935	151	8	.	.	NOUN
ijpds-3935	151	9	6	6	NUM
ijpds-3935	151	10	.	.	X
ijpds-3935	151	11	xu	xu	PROPN
ijpds-3935	152	1	cf	cf	PROPN
ijpds-3935	152	2	,	,	PUNCT
ijpds-3935	152	3	wang	wang	PROPN
ijpds-3935	152	4	j.	j.	PROPN
ijpds-3935	152	5	delivery	delivery	PROPN
ijpds-3935	152	6	systems	system	NOUN
ijpds-3935	152	7	for	for	ADP
ijpds-3935	152	8	sirna	sirna	PROPN
ijpds-3935	152	9	drug	drug	PROPN
ijpds-3935	152	10	development	development	NOUN
ijpds-3935	152	11	in	in	ADP
ijpds-3935	152	12	cancer	cancer	NOUN
ijpds-3935	152	13	therapy	therapy	NOUN
ijpds-3935	152	14	.	.	PUNCT
ijpds-3935	153	1	asian	asian	ADJ
ijpds-3935	153	2	journal	journal	PROPN
ijpds-3935	153	3	of	of	ADP
ijpds-3935	153	4	pharmaceutical	pharmaceutical	NOUN
ijpds-3935	153	5	sciences	science	NOUN
ijpds-3935	153	6	.	.	PUNCT
ijpds-3935	154	1	2015	2015	NUM
ijpds-3935	154	2	feb	feb	X
ijpds-3935	154	3	1;10(1):1	1;10(1):1	NUM
ijpds-3935	154	4	-	-	SYM
ijpds-3935	154	5	2	2	NUM
ijpds-3935	154	6	.	.	NOUN
ijpds-3935	154	7	7	7	NUM
ijpds-3935	154	8	.	.	NOUN
ijpds-3935	154	9	au	au	PROPN
ijpds-3935	154	10	jl	jl	PROPN
ijpds-3935	154	11	,	,	PUNCT
ijpds-3935	154	12	yeung	yeung	PROPN
ijpds-3935	154	13	bz	bz	PROPN
ijpds-3935	154	14	,	,	PUNCT
ijpds-3935	154	15	wientjes	wientjes	VERB
ijpds-3935	154	16	mg	mg	PROPN
ijpds-3935	154	17	,	,	PUNCT
ijpds-3935	154	18	et	et	PROPN
ijpds-3935	154	19	al	al	PROPN
ijpds-3935	154	20	.	.	PUNCT
ijpds-3935	154	21	delivery	delivery	NOUN
ijpds-3935	154	22	of	of	ADP
ijpds-3935	154	23	cancer	cancer	NOUN
ijpds-3935	154	24	therapeutics	therapeutic	NOUN
ijpds-3935	154	25	to	to	ADP
ijpds-3935	154	26	extracellular	extracellular	ADJ
ijpds-3935	154	27	and	and	CCONJ
ijpds-3935	154	28	intracellular	intracellular	ADJ
ijpds-3935	154	29	targets	target	NOUN
ijpds-3935	154	30	:	:	PUNCT
ijpds-3935	154	31	determinants	determinant	NOUN
ijpds-3935	154	32	,	,	PUNCT
ijpds-3935	154	33	barriers	barrier	NOUN
ijpds-3935	154	34	,	,	PUNCT
ijpds-3935	154	35	challenges	challenge	NOUN
ijpds-3935	154	36	and	and	CCONJ
ijpds-3935	154	37	opportunities	opportunity	NOUN
ijpds-3935	154	38	.	.	PUNCT
ijpds-3935	155	1	advanced	advanced	ADJ
ijpds-3935	155	2	drug	drug	NOUN
ijpds-3935	155	3	delivery	delivery	NOUN
ijpds-3935	155	4	reviews	review	NOUN
ijpds-3935	155	5	.	.	PUNCT
ijpds-3935	156	1	2016	2016	NUM
ijpds-3935	156	2	feb	feb	NOUN
ijpds-3935	156	3	1	1	NUM
ijpds-3935	156	4	;	;	PUNCT
ijpds-3935	156	5	97:280	97:280	NUM
ijpds-3935	156	6	-	-	SYM
ijpds-3935	156	7	301	301	NUM
ijpds-3935	156	8	.	.	NOUN
ijpds-3935	156	9	8	8	NUM
ijpds-3935	156	10	.	.	PUNCT
ijpds-3935	157	1	yi	yi	PROPN
ijpds-3935	157	2	xue	xue	PROPN
ijpds-3935	157	3	h	h	PROPN
ijpds-3935	157	4	,	,	PUNCT
ijpds-3935	157	5	guo	guo	PROPN
ijpds-3935	157	6	p	p	X
ijpds-3935	157	7	,	,	PUNCT
ijpds-3935	157	8	wen	wen	PROPN
ijpds-3935	157	9	wc	wc	PROPN
ijpds-3935	157	10	,	,	PUNCT
ijpds-3935	157	11	et	et	PROPN
ijpds-3935	157	12	al	al	PROPN
ijpds-3935	157	13	.	.	PUNCT
ijpds-3935	157	14	lipid	lipid	NOUN
ijpds-3935	157	15	-	-	PUNCT
ijpds-3935	157	16	based	base	VERB
ijpds-3935	157	17	nanocarriers	nanocarrier	NOUN
ijpds-3935	157	18	for	for	ADP
ijpds-3935	157	19	rna	rna	NOUN
ijpds-3935	157	20	delivery	delivery	NOUN
ijpds-3935	157	21	.	.	PUNCT
ijpds-3935	158	1	current	current	ADJ
ijpds-3935	158	2	pharmaceutical	pharmaceutical	ADJ
ijpds-3935	158	3	design	design	NOUN
ijpds-3935	158	4	.	.	PUNCT
ijpds-3935	159	1	2015	2015	NUM
ijpds-3935	159	2	jul	jul	PROPN
ijpds-3935	159	3	1;21(22):3140	1;21(22):3140	NUM
ijpds-3935	159	4	-	-	SYM
ijpds-3935	159	5	7	7	NUM
ijpds-3935	159	6	.	.	NOUN
ijpds-3935	159	7	9	9	NUM
ijpds-3935	159	8	.	.	X
ijpds-3935	160	1	singhal	singhal	PROPN
ijpds-3935	160	2	s	s	PROPN
ijpds-3935	160	3	,	,	PUNCT
ijpds-3935	160	4	nie	nie	PROPN
ijpds-3935	160	5	s	s	PROPN
ijpds-3935	160	6	,	,	PUNCT
ijpds-3935	160	7	wang	wang	PROPN
ijpds-3935	160	8	md	md	PROPN
ijpds-3935	160	9	.	.	PROPN
ijpds-3935	161	1	nanotechnology	nanotechnology	PROPN
ijpds-3935	161	2	applications	application	NOUN
ijpds-3935	161	3	in	in	ADP
ijpds-3935	161	4	surgical	surgical	ADJ
ijpds-3935	161	5	oncology	oncology	NOUN
ijpds-3935	161	6	.	.	PUNCT
ijpds-3935	162	1	annual	annual	ADJ
ijpds-3935	162	2	review	review	NOUN
ijpds-3935	162	3	of	of	ADP
ijpds-3935	162	4	medicine	medicine	NOUN
ijpds-3935	162	5	.	.	PUNCT
ijpds-3935	163	1	2010	2010	NUM
ijpds-3935	163	2	feb	feb	NOUN
ijpds-3935	163	3	18	18	NUM
ijpds-3935	163	4	;	;	PUNCT
ijpds-3935	163	5	61:359	61:359	PROPN
ijpds-3935	163	6	-	-	SYM
ijpds-3935	163	7	73	73	NUM
ijpds-3935	163	8	.	.	PUNCT
ijpds-3935	163	9	10	10	NUM
ijpds-3935	163	10	.	.	PUNCT
ijpds-3935	164	1	danhier	danhier	ADV
ijpds-3935	164	2	f	f	NOUN
ijpds-3935	164	3	,	,	PUNCT
ijpds-3935	164	4	ansorena	ansorena	NOUN
ijpds-3935	164	5	e	e	NOUN
ijpds-3935	164	6	,	,	PUNCT
ijpds-3935	164	7	silva	silva	PROPN
ijpds-3935	164	8	jm	jm	PROPN
ijpds-3935	164	9	,	,	PUNCT
ijpds-3935	164	10	et	et	PROPN
ijpds-3935	164	11	al	al	PROPN
ijpds-3935	164	12	.	.	PROPN
ijpds-3935	164	13	plga	plga	NOUN
ijpds-3935	164	14	-	-	PUNCT
ijpds-3935	164	15	based	base	VERB
ijpds-3935	164	16	nanoparticles	nanoparticle	NOUN
ijpds-3935	164	17	:	:	PUNCT
ijpds-3935	164	18	an	an	DET
ijpds-3935	164	19	overview	overview	NOUN
ijpds-3935	164	20	of	of	ADP
ijpds-3935	164	21	biomedical	biomedical	ADJ
ijpds-3935	164	22	applications	application	NOUN
ijpds-3935	164	23	.	.	PUNCT
ijpds-3935	165	1	journal	journal	PROPN
ijpds-3935	165	2	of	of	ADP
ijpds-3935	165	3	controlled	control	VERB
ijpds-3935	165	4	release	release	NOUN
ijpds-3935	165	5	.	.	PUNCT
ijpds-3935	166	1	2012	2012	NUM
ijpds-3935	166	2	jul	jul	PROPN
ijpds-3935	166	3	20;161(2):505	20;161(2):505	PROPN
ijpds-3935	166	4	-	-	PUNCT
ijpds-3935	166	5	22	22	NUM
ijpds-3935	166	6	.	.	PUNCT
ijpds-3935	166	7	11	11	NUM
ijpds-3935	166	8	.	.	PUNCT
ijpds-3935	167	1	baeza	baeza	PROPN
ijpds-3935	167	2	a	a	PROPN
ijpds-3935	167	3	,	,	PUNCT
ijpds-3935	167	4	ruiz	ruiz	NOUN
ijpds-3935	167	5	-	-	PUNCT
ijpds-3935	167	6	molina	molina	PROPN
ijpds-3935	167	7	d	d	PROPN
ijpds-3935	167	8	,	,	PUNCT
ijpds-3935	167	9	vallet	vallet	NOUN
ijpds-3935	167	10	-	-	PUNCT
ijpds-3935	167	11	regí	regí	NOUN
ijpds-3935	167	12	m.	m.	NOUN
ijpds-3935	167	13	recent	recent	ADJ
ijpds-3935	167	14	advances	advance	NOUN
ijpds-3935	167	15	in	in	ADP
ijpds-3935	167	16	porous	porous	ADJ
ijpds-3935	167	17	nanoparticles	nanoparticle	NOUN
ijpds-3935	167	18	for	for	ADP
ijpds-3935	167	19	drug	drug	NOUN
ijpds-3935	167	20	delivery	delivery	NOUN
ijpds-3935	167	21	in	in	ADP
ijpds-3935	167	22	antitumoral	antitumoral	ADJ
ijpds-3935	167	23	applications	application	NOUN
ijpds-3935	167	24	:	:	PUNCT
ijpds-3935	167	25	inorganic	inorganic	ADJ
ijpds-3935	167	26	nanoparticles	nanoparticle	NOUN
ijpds-3935	167	27	and	and	CCONJ
ijpds-3935	167	28	nanoscale	nanoscale	NOUN
ijpds-3935	167	29	metal	metal	NOUN
ijpds-3935	167	30	-	-	PUNCT
ijpds-3935	167	31	organic	organic	ADJ
ijpds-3935	167	32	frameworks	framework	NOUN
ijpds-3935	167	33	.	.	PUNCT
ijpds-3935	168	1	expert	expert	ADJ
ijpds-3935	168	2	opinion	opinion	NOUN
ijpds-3935	168	3	on	on	ADP
ijpds-3935	168	4	drug	drug	NOUN
ijpds-3935	168	5	delivery	delivery	NOUN
ijpds-3935	168	6	.	.	PUNCT
ijpds-3935	169	1	2017	2017	NUM
ijpds-3935	169	2	jun	jun	PROPN
ijpds-3935	169	3	3;14(6):783	3;14(6):783	NUM
ijpds-3935	169	4	-	-	SYM
ijpds-3935	169	5	96	96	NUM
ijpds-3935	169	6	.	.	PUNCT
ijpds-3935	169	7	12	12	NUM
ijpds-3935	169	8	.	.	PUNCT
ijpds-3935	170	1	ma	ma	PROPN
ijpds-3935	170	2	d.	d.	PROPN
ijpds-3935	170	3	enhancing	enhance	VERB
ijpds-3935	170	4	endosomal	endosomal	ADJ
ijpds-3935	170	5	escape	escape	NOUN
ijpds-3935	170	6	for	for	ADP
ijpds-3935	170	7	nanoparticle	nanoparticle	NOUN
ijpds-3935	170	8	mediated	mediate	VERB
ijpds-3935	170	9	sirna	sirna	PROPN
ijpds-3935	170	10	delivery	delivery	NOUN
ijpds-3935	170	11	.	.	PUNCT
ijpds-3935	171	1	nanoscale	nanoscale	NOUN
ijpds-3935	171	2	.	.	PUNCT
ijpds-3935	172	1	2014;6(12):6415	2014;6(12):6415	NUM
ijpds-3935	172	2	-	-	SYM
ijpds-3935	172	3	25	25	NUM
ijpds-3935	172	4	.	.	NOUN
ijpds-3935	173	1	13	13	NUM
ijpds-3935	173	2	.	.	X
ijpds-3935	174	1	zu	zu	NUM
ijpds-3935	174	2	h	h	NOUN
ijpds-3935	174	3	,	,	PUNCT
ijpds-3935	174	4	gao	gao	PROPN
ijpds-3935	174	5	d.	d.	PROPN
ijpds-3935	174	6	non	non	ADJ
ijpds-3935	174	7	-	-	ADJ
ijpds-3935	174	8	viral	viral	ADJ
ijpds-3935	174	9	vectors	vector	NOUN
ijpds-3935	174	10	in	in	ADP
ijpds-3935	174	11	gene	gene	NOUN
ijpds-3935	174	12	therapy	therapy	NOUN
ijpds-3935	174	13	:	:	PUNCT
ijpds-3935	174	14	recent	recent	ADJ
ijpds-3935	174	15	development	development	NOUN
ijpds-3935	174	16	,	,	PUNCT
ijpds-3935	174	17	challenges	challenge	NOUN
ijpds-3935	174	18	,	,	PUNCT
ijpds-3935	174	19	and	and	CCONJ
ijpds-3935	174	20	prospects	prospect	NOUN
ijpds-3935	174	21	.	.	PUNCT
ijpds-3935	175	1	the	the	DET
ijpds-3935	175	2	aaps	aaps	PROPN
ijpds-3935	175	3	journal	journal	NOUN
ijpds-3935	175	4	.	.	PUNCT
ijpds-3935	176	1	2021	2021	NUM
ijpds-3935	176	2	jun	jun	PROPN
ijpds-3935	176	3	2;23(4):78	2;23(4):78	NUM
ijpds-3935	176	4	-	-	PUNCT
ijpds-3935	176	5	9	9	NUM
ijpds-3935	176	6	.	.	NOUN
ijpds-3935	176	7	14	14	NUM
ijpds-3935	176	8	.	.	PUNCT
ijpds-3935	177	1	nakase	nakase	PROPN
ijpds-3935	177	2	i	i	PRON
ijpds-3935	177	3	,	,	PUNCT
ijpds-3935	177	4	tanaka	tanaka	PROPN
ijpds-3935	177	5	g	g	PROPN
ijpds-3935	177	6	,	,	PUNCT
ijpds-3935	177	7	futaki	futaki	NOUN
ijpds-3935	177	8	s.	s.	PROPN
ijpds-3935	177	9	cell	cell	NOUN
ijpds-3935	177	10	-	-	PUNCT
ijpds-3935	177	11	penetrating	penetrate	VERB
ijpds-3935	177	12	peptides	peptide	NOUN
ijpds-3935	177	13	(	(	PUNCT
ijpds-3935	177	14	cpps	cpps	NOUN
ijpds-3935	177	15	)	)	PUNCT
ijpds-3935	177	16	as	as	ADP
ijpds-3935	177	17	a	a	DET
ijpds-3935	177	18	vector	vector	NOUN
ijpds-3935	177	19	for	for	ADP
ijpds-3935	177	20	the	the	DET
ijpds-3935	177	21	delivery	delivery	NOUN
ijpds-3935	177	22	of	of	ADP
ijpds-3935	177	23	sirnas	sirna	NOUN
ijpds-3935	177	24	into	into	ADP
ijpds-3935	177	25	cells	cell	NOUN
ijpds-3935	177	26	.	.	PUNCT
ijpds-3935	178	1	molecular	molecular	ADJ
ijpds-3935	178	2	biosystems	biosystem	NOUN
ijpds-3935	178	3	.	.	PUNCT
ijpds-3935	179	1	2013;9(5):855	2013;9(5):855	X
ijpds-3935	179	2	-	-	SYM
ijpds-3935	179	3	61	61	NUM
ijpds-3935	179	4	.	.	PUNCT
ijpds-3935	180	1	15	15	NUM
ijpds-3935	180	2	.	.	PUNCT
ijpds-3935	181	1	mirzaei	mirzaei	PROPN
ijpds-3935	181	2	s	s	PROPN
ijpds-3935	181	3	,	,	PUNCT
ijpds-3935	181	4	gholami	gholami	PROPN
ijpds-3935	181	5	mh	mh	PROPN
ijpds-3935	181	6	,	,	PUNCT
ijpds-3935	181	7	ang	ang	PROPN
ijpds-3935	181	8	hl	hl	PROPN
ijpds-3935	181	9	,	,	PUNCT
ijpds-3935	181	10	et	et	PROPN
ijpds-3935	181	11	al	al	PROPN
ijpds-3935	181	12	.	.	PUNCT
ijpds-3935	182	1	pre	pre	ADJ
ijpds-3935	182	2	-	-	ADJ
ijpds-3935	182	3	clinical	clinical	ADJ
ijpds-3935	182	4	and	and	CCONJ
ijpds-3935	182	5	clinical	clinical	ADJ
ijpds-3935	182	6	applications	application	NOUN
ijpds-3935	182	7	of	of	ADP
ijpds-3935	182	8	small	small	ADJ
ijpds-3935	182	9	interfering	interfere	VERB
ijpds-3935	182	10	rnas	rna	NOUN
ijpds-3935	182	11	(	(	PUNCT
ijpds-3935	182	12	sirna	sirna	PROPN
ijpds-3935	182	13	)	)	PUNCT
ijpds-3935	182	14	and	and	CCONJ
ijpds-3935	182	15	co	co	NOUN
ijpds-3935	182	16	-	-	NOUN
ijpds-3935	182	17	delivery	delivery	NOUN
ijpds-3935	182	18	systems	system	NOUN
ijpds-3935	182	19	for	for	ADP
ijpds-3935	182	20	pancreatic	pancreatic	ADJ
ijpds-3935	182	21	cancer	cancer	NOUN
ijpds-3935	182	22	therapy	therapy	NOUN
ijpds-3935	182	23	.	.	PUNCT
ijpds-3935	183	1	cells	cell	NOUN
ijpds-3935	183	2	.	.	PUNCT
ijpds-3935	184	1	2021	2021	NUM
ijpds-3935	184	2	nov	nov	NOUN
ijpds-3935	184	3	29;10(12):3348	29;10(12):3348	NUM
ijpds-3935	184	4	-	-	SYM
ijpds-3935	184	5	9	9	NUM
ijpds-3935	184	6	.	.	NOUN
ijpds-3935	184	7	16	16	NUM
ijpds-3935	184	8	.	.	PUNCT
ijpds-3935	185	1	lam	lam	PROPN
ijpds-3935	185	2	jk	jk	PROPN
ijpds-3935	185	3	,	,	PUNCT
ijpds-3935	185	4	chow	chow	VERB
ijpds-3935	185	5	my	my	PRON
ijpds-3935	185	6	,	,	PUNCT
ijpds-3935	185	7	zhang	zhang	PROPN
ijpds-3935	185	8	y	y	PROPN
ijpds-3935	185	9	,	,	PUNCT
ijpds-3935	185	10	et	et	PROPN
ijpds-3935	185	11	al	al	PROPN
ijpds-3935	185	12	.	.	PUNCT
ijpds-3935	186	1	sirna	sirna	PROPN
ijpds-3935	186	2	versus	versus	ADP
ijpds-3935	186	3	mirna	mirna	PROPN
ijpds-3935	186	4	as	as	ADP
ijpds-3935	186	5	therapeutics	therapeutic	NOUN
ijpds-3935	186	6	for	for	ADP
ijpds-3935	186	7	gene	gene	NOUN
ijpds-3935	186	8	silencing	silence	VERB
ijpds-3935	186	9	.	.	PUNCT
ijpds-3935	187	1	molecular	molecular	ADJ
ijpds-3935	187	2	therapy	therapy	NOUN
ijpds-3935	187	3	-	-	PUNCT
ijpds-3935	187	4	nucleic	nucleic	ADJ
ijpds-3935	187	5	acids	acid	NOUN
ijpds-3935	187	6	.	.	PUNCT
ijpds-3935	188	1	2015	2015	NUM
ijpds-3935	188	2	jan	jan	NOUN
ijpds-3935	188	3	1;4	1;4	NUM
ijpds-3935	188	4	:	:	PUNCT
ijpds-3935	188	5	e252	e252	PROPN
ijpds-3935	188	6	.	.	PROPN
ijpds-3935	188	7	17	17	NUM
ijpds-3935	188	8	.	.	PUNCT
ijpds-3935	188	9	jackson	jackson	PROPN
ijpds-3935	188	10	al	al	PROPN
ijpds-3935	188	11	,	,	PUNCT
ijpds-3935	188	12	linsley	linsley	PROPN
ijpds-3935	188	13	ps	ps	PROPN
ijpds-3935	188	14	.	.	PUNCT
ijpds-3935	188	15	recognizing	recognize	VERB
ijpds-3935	188	16	and	and	CCONJ
ijpds-3935	188	17	avoiding	avoid	VERB
ijpds-3935	188	18	sirna	sirna	PROPN
ijpds-3935	188	19	offtarget	offtarget	NOUN
ijpds-3935	188	20	effects	effect	NOUN
ijpds-3935	188	21	for	for	ADP
ijpds-3935	188	22	target	target	NOUN
ijpds-3935	188	23	identification	identification	NOUN
ijpds-3935	188	24	and	and	CCONJ
ijpds-3935	188	25	therapeutic	therapeutic	ADJ
ijpds-3935	188	26	application	application	NOUN
ijpds-3935	188	27	.	.	PUNCT
ijpds-3935	189	1	nature	nature	NOUN
ijpds-3935	189	2	reviews	review	VERB
ijpds-3935	189	3	drug	drug	NOUN
ijpds-3935	189	4	discovery	discovery	NOUN
ijpds-3935	189	5	.	.	PUNCT
ijpds-3935	190	1	2010	2010	NUM
ijpds-3935	190	2	jan	jan	NOUN
ijpds-3935	190	3	;	;	PUNCT
ijpds-3935	190	4	9(1	9(1	NUM
ijpds-3935	190	5	):	):	PUNCT
ijpds-3935	190	6	57	57	NUM
ijpds-3935	190	7	-	-	SYM
ijpds-3935	190	8	67	67	NUM
ijpds-3935	190	9	.	.	PUNCT
ijpds-3935	190	10	18	18	NUM
ijpds-3935	190	11	.	.	PUNCT
ijpds-3935	191	1	julier	juli	ADJ
ijpds-3935	191	2	z	z	PROPN
ijpds-3935	191	3	,	,	PUNCT
ijpds-3935	191	4	park	park	PROPN
ijpds-3935	191	5	aj	aj	PROPN
ijpds-3935	191	6	,	,	PUNCT
ijpds-3935	191	7	briquez	briquez	NOUN
ijpds-3935	191	8	ps	ps	PROPN
ijpds-3935	191	9	,	,	PUNCT
ijpds-3935	191	10	et	et	PROPN
ijpds-3935	191	11	al	al	PROPN
ijpds-3935	191	12	.	.	PUNCT
ijpds-3935	192	1	promoting	promote	VERB
ijpds-3935	192	2	tissue	tissue	NOUN
ijpds-3935	192	3	regeneration	regeneration	NOUN
ijpds-3935	192	4	by	by	ADP
ijpds-3935	192	5	modulating	modulate	VERB
ijpds-3935	192	6	the	the	DET
ijpds-3935	192	7	immune	immune	ADJ
ijpds-3935	192	8	system	system	NOUN
ijpds-3935	192	9	.	.	PUNCT
ijpds-3935	193	1	acta	acta	PROPN
ijpds-3935	193	2	biomaterialia	biomaterialia	PROPN
ijpds-3935	193	3	.	.	PUNCT
ijpds-3935	194	1	2017	2017	NUM
ijpds-3935	194	2	apr	apr	NOUN
ijpds-3935	194	3	15	15	NUM
ijpds-3935	194	4	;	;	PUNCT
ijpds-3935	194	5	53:13	53:13	NUM
ijpds-3935	194	6	-	-	SYM
ijpds-3935	194	7	28	28	NUM
ijpds-3935	194	8	.	.	PUNCT
ijpds-3935	194	9	19	19	NUM
ijpds-3935	194	10	.	.	PUNCT
ijpds-3935	194	11	gomes	gomes	PROPN
ijpds-3935	194	12	-	-	PUNCT
ijpds-3935	194	13	da	da	PROPN
ijpds-3935	194	14	-	-	PUNCT
ijpds-3935	194	15	silva	silva	NOUN
ijpds-3935	194	16	lc	lc	PROPN
ijpds-3935	194	17	,	,	PUNCT
ijpds-3935	194	18	fonseca	fonseca	PROPN
ijpds-3935	194	19	na	na	PROPN
ijpds-3935	194	20	,	,	PUNCT
ijpds-3935	194	21	moura	moura	NOUN
ijpds-3935	194	22	v	v	PROPN
ijpds-3935	194	23	,	,	PUNCT
ijpds-3935	194	24	et	et	PROPN
ijpds-3935	194	25	al	al	PROPN
ijpds-3935	194	26	.	.	PUNCT
ijpds-3935	194	27	lipid	lipid	NOUN
ijpds-3935	194	28	-	-	PUNCT
ijpds-3935	194	29	based	base	VERB
ijpds-3935	194	30	nanoparticles	nanoparticle	NOUN
ijpds-3935	194	31	for	for	ADP
ijpds-3935	194	32	sirna	sirna	PROPN
ijpds-3935	194	33	delivery	delivery	NOUN
ijpds-3935	194	34	in	in	ADP
ijpds-3935	194	35	cancer	cancer	NOUN
ijpds-3935	194	36	therapy	therapy	NOUN
ijpds-3935	194	37	:	:	PUNCT
ijpds-3935	194	38	paradigms	paradigm	NOUN
ijpds-3935	194	39	and	and	CCONJ
ijpds-3935	194	40	challenges	challenge	NOUN
ijpds-3935	194	41	.	.	PUNCT
ijpds-3935	195	1	accounts	account	NOUN
ijpds-3935	195	2	of	of	ADP
ijpds-3935	195	3	chemical	chemical	ADJ
ijpds-3935	195	4	research	research	NOUN
ijpds-3935	195	5	.	.	PUNCT
ijpds-3935	196	1	2012	2012	NUM
ijpds-3935	196	2	jul	jul	PROPN
ijpds-3935	196	3	17;45(7):1163	17;45(7):1163	NUM
ijpds-3935	196	4	-	-	SYM
ijpds-3935	196	5	71	71	NUM
ijpds-3935	196	6	.	.	PUNCT
ijpds-3935	196	7	20	20	NUM
ijpds-3935	196	8	.	.	PUNCT
ijpds-3935	196	9	xu	xu	PROPN
ijpds-3935	197	1	l	l	NOUN
ijpds-3935	197	2	,	,	PUNCT
ijpds-3935	197	3	anchordoquy	anchordoquy	ADJ
ijpds-3935	197	4	t.	t.	NOUN
ijpds-3935	197	5	drug	drug	NOUN
ijpds-3935	197	6	delivery	delivery	NOUN
ijpds-3935	197	7	trends	trend	NOUN
ijpds-3935	197	8	in	in	ADP
ijpds-3935	197	9	clinical	clinical	ADJ
ijpds-3935	197	10	trials	trial	NOUN
ijpds-3935	197	11	and	and	CCONJ
ijpds-3935	197	12	translational	translational	ADJ
ijpds-3935	197	13	medicine	medicine	NOUN
ijpds-3935	197	14	:	:	PUNCT
ijpds-3935	197	15	challenges	challenge	NOUN
ijpds-3935	197	16	and	and	CCONJ
ijpds-3935	197	17	opportunities	opportunity	NOUN
ijpds-3935	197	18	in	in	ADP
ijpds-3935	197	19	the	the	DET
ijpds-3935	197	20	delivery	delivery	NOUN
ijpds-3935	197	21	of	of	ADP
ijpds-3935	197	22	nucleic	nucleic	ADJ
ijpds-3935	197	23	acid‐based	acid‐based	ADJ
ijpds-3935	197	24	therapeutics	therapeutic	NOUN
ijpds-3935	197	25	.	.	PUNCT
ijpds-3935	198	1	journal	journal	PROPN
ijpds-3935	198	2	of	of	ADP
ijpds-3935	198	3	pharmaceutical	pharmaceutical	NOUN
ijpds-3935	198	4	sciences	science	NOUN
ijpds-3935	198	5	.	.	PUNCT
ijpds-3935	199	1	2011	2011	NUM
ijpds-3935	199	2	jan;100(1):38	jan;100(1):38	PROPN
ijpds-3935	199	3	-	-	PUNCT
ijpds-3935	199	4	52	52	NUM
ijpds-3935	199	5	.	.	PUNCT
ijpds-3935	199	6	21	21	NUM
ijpds-3935	199	7	.	.	PUNCT
ijpds-3935	200	1	ozcan	ozcan	PROPN
ijpds-3935	200	2	g	g	NOUN
ijpds-3935	200	3	,	,	PUNCT
ijpds-3935	200	4	ozpolat	ozpolat	ADJ
ijpds-3935	200	5	b	b	NOUN
ijpds-3935	200	6	,	,	PUNCT
ijpds-3935	200	7	coleman	coleman	PROPN
ijpds-3935	200	8	rl	rl	PROPN
ijpds-3935	200	9	,	,	PUNCT
ijpds-3935	200	10	et	et	PROPN
ijpds-3935	200	11	al	al	PROPN
ijpds-3935	200	12	.	.	PROPN
ijpds-3935	201	1	preclinical	preclinical	ADJ
ijpds-3935	201	2	and	and	CCONJ
ijpds-3935	201	3	clinical	clinical	ADJ
ijpds-3935	201	4	development	development	NOUN
ijpds-3935	201	5	of	of	ADP
ijpds-3935	201	6	sirna	sirna	PROPN
ijpds-3935	201	7	-	-	PUNCT
ijpds-3935	201	8	based	base	VERB
ijpds-3935	201	9	therapeutics	therapeutic	NOUN
ijpds-3935	201	10	.	.	PUNCT
ijpds-3935	202	1	advanced	advanced	ADJ
ijpds-3935	202	2	drug	drug	NOUN
ijpds-3935	202	3	delivery	delivery	NOUN
ijpds-3935	202	4	reviews	review	NOUN
ijpds-3935	202	5	.	.	PUNCT
ijpds-3935	203	1	2015	2015	NUM
ijpds-3935	203	2	jun	jun	PROPN
ijpds-3935	203	3	29	29	NUM
ijpds-3935	203	4	;	;	PUNCT
ijpds-3935	203	5	87:108	87:108	NUM
ijpds-3935	203	6	-	-	SYM
ijpds-3935	203	7	19	19	NUM
ijpds-3935	203	8	.	.	NOUN
ijpds-3935	203	9	22	22	NUM
ijpds-3935	203	10	.	.	PUNCT
ijpds-3935	204	1	kristen	kristen	PROPN
ijpds-3935	204	2	av	av	PROPN
ijpds-3935	204	3	,	,	PUNCT
ijpds-3935	204	4	ajroud	ajroud	NOUN
ijpds-3935	204	5	-	-	PUNCT
ijpds-3935	204	6	driss	driss	PROPN
ijpds-3935	204	7	s	s	PROPN
ijpds-3935	204	8	,	,	PUNCT
ijpds-3935	204	9	conceição	conceição	PROPN
ijpds-3935	204	10	i	i	PROPN
ijpds-3935	204	11	,	,	PUNCT
ijpds-3935	204	12	et	et	PROPN
ijpds-3935	204	13	al	al	PROPN
ijpds-3935	204	14	.	.	PROPN
ijpds-3935	204	15	patisiran	patisiran	PROPN
ijpds-3935	204	16	,	,	PUNCT
ijpds-3935	204	17	an	an	DET
ijpds-3935	204	18	rnai	rnai	NOUN
ijpds-3935	204	19	therapeutic	therapeutic	ADJ
ijpds-3935	204	20	for	for	ADP
ijpds-3935	204	21	the	the	DET
ijpds-3935	204	22	treatment	treatment	NOUN
ijpds-3935	204	23	of	of	ADP
ijpds-3935	204	24	hereditary	hereditary	ADJ
ijpds-3935	204	25	transthyretin	transthyretin	ADV
ijpds-3935	204	26	-	-	PUNCT
ijpds-3935	204	27	mediated	mediate	VERB
ijpds-3935	204	28	amyloidosis	amyloidosis	NOUN
ijpds-3935	204	29	.	.	PUNCT
ijpds-3935	205	1	neurodegenerative	neurodegenerative	ADJ
ijpds-3935	205	2	disease	disease	NOUN
ijpds-3935	205	3	management	management	NOUN
ijpds-3935	205	4	.	.	PUNCT
ijpds-3935	206	1	2019	2019	NUM
ijpds-3935	206	2	feb;9(1):5	feb;9(1):5	NOUN
ijpds-3935	206	3	-	-	SYM
ijpds-3935	206	4	23	23	NUM
ijpds-3935	206	5	.	.	PUNCT
ijpds-3935	207	1	23	23	NUM
ijpds-3935	207	2	.	.	PUNCT
ijpds-3935	208	1	wang	wang	PROPN
ijpds-3935	208	2	x	x	PROPN
ijpds-3935	208	3	,	,	PUNCT
ijpds-3935	208	4	chen	chen	PROPN
ijpds-3935	208	5	x	x	PROPN
ijpds-3935	208	6	,	,	PUNCT
ijpds-3935	208	7	zhang	zhang	PROPN
ijpds-3935	208	8	x	x	PROPN
ijpds-3935	208	9	,	,	PUNCT
ijpds-3935	208	10	et	et	PROPN
ijpds-3935	208	11	al	al	PROPN
ijpds-3935	208	12	.	.	PUNCT
ijpds-3935	209	1	a	a	DET
ijpds-3935	209	2	small	small	ADJ
ijpds-3935	209	3	-	-	PUNCT
ijpds-3935	209	4	molecule	molecule	NOUN
ijpds-3935	209	5	inhibitor	inhibitor	NOUN
ijpds-3935	209	6	of	of	ADP
ijpds-3935	209	7	pcsk9	pcsk9	NOUN
ijpds-3935	209	8	transcription	transcription	NOUN
ijpds-3935	209	9	ameliorates	ameliorate	VERB
ijpds-3935	209	10	atherosclerosis	atherosclerosis	NOUN
ijpds-3935	209	11	through	through	ADP
ijpds-3935	209	12	the	the	DET
ijpds-3935	209	13	shanbhag	shanbhag	NOUN
ijpds-3935	209	14	et	et	PROPN
ijpds-3935	209	15	al	al	PROPN
ijpds-3935	209	16	.	.	PUNCT
ijpds-3935	209	17	cancer	cancer	NOUN
ijpds-3935	209	18	therapy	therapy	NOUN
ijpds-3935	209	19	:	:	PUNCT
ijpds-3935	209	20	an	an	DET
ijpds-3935	209	21	overview	overview	NOUN
ijpds-3935	209	22	of	of	ADP
ijpds-3935	209	23	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	209	24	strategies	strategy	NOUN
ijpds-3935	209	25	vol	vol	VERB
ijpds-3935	209	26	2|	2|	NUM
ijpds-3935	209	27	issue	issue	NOUN
ijpds-3935	209	28	2	2	NUM
ijpds-3935	209	29	|	|	ADV
ijpds-3935	209	30	apr	apr	ADV
ijpds-3935	209	31	–	–	PUNCT
ijpds-3935	209	32	jun	jun	PROPN
ijpds-3935	209	33	2023	2023	NUM
ijpds-3935	209	34	indian	indian	PROPN
ijpds-3935	209	35	j	j	PROPN
ijpds-3935	209	36	pharm	pharm	PROPN
ijpds-3935	209	37	drug	drug	PROPN
ijpds-3935	209	38	studies	study	NOUN
ijpds-3935	209	39	|	|	ADV
ijpds-3935	209	40	68	68	NUM
ijpds-3935	209	41	modulation	modulation	NOUN
ijpds-3935	209	42	of	of	ADP
ijpds-3935	209	43	foxo1/3	foxo1/3	NOUN
ijpds-3935	209	44	and	and	CCONJ
ijpds-3935	209	45	hnf1α	hnf1α	PROPN
ijpds-3935	209	46	.	.	PUNCT
ijpds-3935	210	1	ebiomedicine	ebiomedicine	PROPN
ijpds-3935	210	2	.	.	PUNCT
ijpds-3935	211	1	2020	2020	NUM
ijpds-3935	211	2	feb	feb	NOUN
ijpds-3935	211	3	1	1	NUM
ijpds-3935	211	4	;	;	PUNCT
ijpds-3935	211	5	52:102650	52:102650	NUM
ijpds-3935	211	6	.	.	NOUN
ijpds-3935	212	1	24	24	NUM
ijpds-3935	212	2	.	.	PUNCT
ijpds-3935	212	3	hu	hu	PROPN
ijpds-3935	213	1	b	b	PROPN
ijpds-3935	213	2	,	,	PUNCT
ijpds-3935	213	3	weng	weng	PROPN
ijpds-3935	213	4	y	y	PROPN
ijpds-3935	213	5	,	,	PUNCT
ijpds-3935	213	6	xia	xia	PROPN
ijpds-3935	213	7	xh	xh	PROPN
ijpds-3935	213	8	,	,	PUNCT
ijpds-3935	213	9	et	et	PROPN
ijpds-3935	213	10	al	al	PROPN
ijpds-3935	213	11	.	.	PUNCT
ijpds-3935	214	1	clinical	clinical	ADJ
ijpds-3935	214	2	advances	advance	NOUN
ijpds-3935	214	3	of	of	ADP
ijpds-3935	214	4	sirna	sirna	PROPN
ijpds-3935	214	5	therapeutics	therapeutic	NOUN
ijpds-3935	214	6	.	.	PUNCT
ijpds-3935	215	1	the	the	DET
ijpds-3935	215	2	journal	journal	NOUN
ijpds-3935	215	3	of	of	ADP
ijpds-3935	215	4	gene	gene	NOUN
ijpds-3935	215	5	medicine	medicine	NOUN
ijpds-3935	215	6	.	.	PUNCT
ijpds-3935	216	1	2019	2019	NUM
ijpds-3935	216	2	jul;21(7	jul;21(7	NOUN
ijpds-3935	216	3	):	):	PUNCT
ijpds-3935	216	4	e3097	e3097	PROPN
ijpds-3935	216	5	.	.	PROPN
ijpds-3935	217	1	25	25	NUM
ijpds-3935	217	2	.	.	PUNCT
ijpds-3935	217	3	yu	yu	PROPN
ijpds-3935	217	4	h	h	PROPN
ijpds-3935	217	5	,	,	PUNCT
ijpds-3935	217	6	liu	liu	PROPN
ijpds-3935	217	7	d	d	PROPN
ijpds-3935	217	8	,	,	PUNCT
ijpds-3935	217	9	shu	shu	PROPN
ijpds-3935	217	10	g	g	PROPN
ijpds-3935	217	11	,	,	PUNCT
ijpds-3935	217	12	et	et	PROPN
ijpds-3935	217	13	al	al	PROPN
ijpds-3935	217	14	.	.	PUNCT
ijpds-3935	218	1	recent	recent	ADJ
ijpds-3935	218	2	advances	advance	NOUN
ijpds-3935	218	3	in	in	ADP
ijpds-3935	218	4	nanotherapeutics	nanotherapeutic	NOUN
ijpds-3935	218	5	for	for	ADP
ijpds-3935	218	6	the	the	DET
ijpds-3935	218	7	treatment	treatment	NOUN
ijpds-3935	218	8	and	and	CCONJ
ijpds-3935	218	9	prevention	prevention	NOUN
ijpds-3935	218	10	of	of	ADP
ijpds-3935	218	11	acute	acute	ADJ
ijpds-3935	218	12	kidney	kidney	NOUN
ijpds-3935	218	13	injury	injury	NOUN
ijpds-3935	218	14	.	.	PUNCT
ijpds-3935	219	1	asian	asian	ADJ
ijpds-3935	219	2	journal	journal	PROPN
ijpds-3935	219	3	of	of	ADP
ijpds-3935	219	4	pharmaceutical	pharmaceutical	NOUN
ijpds-3935	219	5	sciences	science	NOUN
ijpds-3935	219	6	.	.	PUNCT
ijpds-3935	220	1	2021	2021	NUM
ijpds-3935	220	2	jul;16(4):432–43	jul;16(4):432–43	PROPN
ijpds-3935	220	3	.	.	PUNCT
ijpds-3935	221	1	26	26	NUM
ijpds-3935	221	2	.	.	PUNCT
ijpds-3935	222	1	chen	chen	PROPN
ijpds-3935	222	2	x	x	PROPN
ijpds-3935	222	3	,	,	PUNCT
ijpds-3935	222	4	mangala	mangala	PROPN
ijpds-3935	222	5	ls	ls	PROPN
ijpds-3935	222	6	,	,	PUNCT
ijpds-3935	222	7	rodriguez	rodriguez	NOUN
ijpds-3935	222	8	-	-	PUNCT
ijpds-3935	222	9	aguayo	aguayo	PROPN
ijpds-3935	222	10	c	c	PROPN
ijpds-3935	222	11	,	,	PUNCT
ijpds-3935	222	12	et	et	PROPN
ijpds-3935	222	13	al	al	PROPN
ijpds-3935	222	14	.	.	PUNCT
ijpds-3935	222	15	rna	rna	PROPN
ijpds-3935	222	16	interference	interference	NOUN
ijpds-3935	222	17	-	-	PUNCT
ijpds-3935	222	18	based	base	VERB
ijpds-3935	222	19	therapy	therapy	NOUN
ijpds-3935	222	20	and	and	CCONJ
ijpds-3935	222	21	its	its	PRON
ijpds-3935	222	22	delivery	delivery	NOUN
ijpds-3935	222	23	systems	system	NOUN
ijpds-3935	222	24	.	.	PUNCT
ijpds-3935	223	1	cancer	cancer	NOUN
ijpds-3935	223	2	and	and	CCONJ
ijpds-3935	223	3	metastasis	metastasis	NOUN
ijpds-3935	223	4	reviews	review	NOUN
ijpds-3935	223	5	.	.	PUNCT
ijpds-3935	224	1	2017	2017	NUM
ijpds-3935	224	2	dec	dec	PROPN
ijpds-3935	224	3	14;37(1):107–24	14;37(1):107–24	NUM
ijpds-3935	224	4	.	.	PROPN
ijpds-3935	224	5	27	27	NUM
ijpds-3935	224	6	.	.	PUNCT
ijpds-3935	225	1	lee	lee	PROPN
ijpds-3935	225	2	sj	sj	PROPN
ijpds-3935	225	3	,	,	PUNCT
ijpds-3935	225	4	kim	kim	PROPN
ijpds-3935	225	5	mj	mj	PROPN
ijpds-3935	225	6	,	,	PUNCT
ijpds-3935	225	7	kwon	kwon	VERB
ijpds-3935	225	8	ic	ic	PROPN
ijpds-3935	225	9	,	,	PUNCT
ijpds-3935	225	10	et	et	PROPN
ijpds-3935	225	11	al	al	PROPN
ijpds-3935	225	12	.	.	PUNCT
ijpds-3935	226	1	delivery	delivery	NOUN
ijpds-3935	226	2	strategies	strategy	NOUN
ijpds-3935	226	3	and	and	CCONJ
ijpds-3935	226	4	potential	potential	ADJ
ijpds-3935	226	5	targets	target	NOUN
ijpds-3935	226	6	for	for	ADP
ijpds-3935	226	7	sirna	sirna	PROPN
ijpds-3935	226	8	in	in	ADP
ijpds-3935	226	9	major	major	ADJ
ijpds-3935	226	10	cancer	cancer	NOUN
ijpds-3935	226	11	types	type	NOUN
ijpds-3935	226	12	.	.	PUNCT
ijpds-3935	227	1	advanced	advanced	ADJ
ijpds-3935	227	2	drug	drug	NOUN
ijpds-3935	227	3	delivery	delivery	NOUN
ijpds-3935	227	4	reviews	review	NOUN
ijpds-3935	227	5	.	.	PUNCT
ijpds-3935	228	1	2016	2016	NUM
ijpds-3935	228	2	sep	sep	NOUN
ijpds-3935	228	3	;	;	PUNCT
ijpds-3935	228	4	104:2–15	104:2–15	NUM
ijpds-3935	228	5	.	.	NOUN
ijpds-3935	228	6	28	28	NUM
ijpds-3935	228	7	.	.	PUNCT
ijpds-3935	229	1	hattab	hattab	PROPN
ijpds-3935	229	2	d	d	PROPN
ijpds-3935	229	3	,	,	PUNCT
ijpds-3935	229	4	gazzali	gazzali	PROPN
ijpds-3935	229	5	am	am	PROPN
ijpds-3935	229	6	,	,	PUNCT
ijpds-3935	229	7	bakhtiar	bakhtiar	ADJ
ijpds-3935	229	8	a.	a.	NOUN
ijpds-3935	229	9	clinical	clinical	PROPN
ijpds-3935	229	10	advances	advance	NOUN
ijpds-3935	229	11	of	of	ADP
ijpds-3935	229	12	sirnabased	sirnabase	VERB
ijpds-3935	229	13	nanotherapeutics	nanotherapeutic	NOUN
ijpds-3935	229	14	for	for	ADP
ijpds-3935	229	15	cancer	cancer	NOUN
ijpds-3935	229	16	treatment	treatment	NOUN
ijpds-3935	229	17	.	.	PUNCT
ijpds-3935	230	1	pharmaceutics	pharmaceutic	NOUN
ijpds-3935	230	2	.	.	PUNCT
ijpds-3935	231	1	2021	2021	NUM
ijpds-3935	231	2	jul	jul	PROPN
ijpds-3935	231	3	2;13(7):1009	2;13(7):1009	NUM
ijpds-3935	231	4	-	-	SYM
ijpds-3935	231	5	10	10	NUM
ijpds-3935	231	6	.	.	PUNCT
ijpds-3935	231	7	29	29	NUM
ijpds-3935	231	8	.	.	PUNCT
ijpds-3935	232	1	deng	deng	PROPN
ijpds-3935	232	2	w	w	PROPN
ijpds-3935	232	3	,	,	PUNCT
ijpds-3935	232	4	chen	chen	PROPN
ijpds-3935	232	5	w	w	PROPN
ijpds-3935	232	6	,	,	PUNCT
ijpds-3935	232	7	clement	clement	PROPN
ijpds-3935	232	8	s	s	PROPN
ijpds-3935	232	9	,	,	PUNCT
ijpds-3935	232	10	et	et	PROPN
ijpds-3935	232	11	al	al	PROPN
ijpds-3935	232	12	.	.	PROPN
ijpds-3935	232	13	controlled	control	VERB
ijpds-3935	232	14	gene	gene	NOUN
ijpds-3935	232	15	and	and	CCONJ
ijpds-3935	232	16	drug	drug	NOUN
ijpds-3935	232	17	release	release	NOUN
ijpds-3935	232	18	from	from	ADP
ijpds-3935	232	19	a	a	DET
ijpds-3935	232	20	liposomal	liposomal	ADJ
ijpds-3935	232	21	delivery	delivery	NOUN
ijpds-3935	232	22	platform	platform	NOUN
ijpds-3935	232	23	triggered	trigger	VERB
ijpds-3935	232	24	by	by	ADP
ijpds-3935	232	25	x	x	NOUN
ijpds-3935	232	26	-	-	NOUN
ijpds-3935	232	27	ray	ray	NOUN
ijpds-3935	232	28	radiation	radiation	NOUN
ijpds-3935	232	29	.	.	PUNCT
ijpds-3935	233	1	nature	nature	NOUN
ijpds-3935	233	2	communications	communication	NOUN
ijpds-3935	233	3	.	.	PUNCT
ijpds-3935	234	1	2018	2018	NUM
ijpds-3935	234	2	jul	jul	PROPN
ijpds-3935	234	3	13;9(1):2713	13;9(1):2713	NUM
ijpds-3935	234	4	.	.	PUNCT
ijpds-3935	234	5	30	30	NUM
ijpds-3935	234	6	.	.	PUNCT
ijpds-3935	235	1	li	li	PROPN
ijpds-3935	235	2	rt	rt	PROPN
ijpds-3935	235	3	,	,	PUNCT
ijpds-3935	235	4	zhu	zhu	PROPN
ijpds-3935	235	5	yd	yd	PROPN
ijpds-3935	235	6	,	,	PUNCT
ijpds-3935	235	7	li	li	PROPN
ijpds-3935	235	8	wy	wy	PROPN
ijpds-3935	235	9	,	,	PUNCT
ijpds-3935	235	10	et	et	PROPN
ijpds-3935	235	11	al	al	PROPN
ijpds-3935	235	12	.	.	PROPN
ijpds-3935	236	1	synergistic	synergistic	ADJ
ijpds-3935	236	2	photothermalphotodynamic	photothermalphotodynamic	NOUN
ijpds-3935	236	3	-	-	PUNCT
ijpds-3935	236	4	chemotherapy	chemotherapy	NOUN
ijpds-3935	236	5	toward	toward	ADP
ijpds-3935	236	6	breast	breast	NOUN
ijpds-3935	236	7	cancer	cancer	NOUN
ijpds-3935	236	8	based	base	VERB
ijpds-3935	236	9	on	on	ADP
ijpds-3935	236	10	a	a	DET
ijpds-3935	236	11	liposome	liposome	NOUN
ijpds-3935	236	12	-	-	PUNCT
ijpds-3935	236	13	coated	coat	VERB
ijpds-3935	236	14	core	core	NOUN
ijpds-3935	236	15	–	–	PUNCT
ijpds-3935	236	16	shell	shell	ADJ
ijpds-3935	236	17	auns@	auns@	PROPN
ijpds-3935	236	18	nmofs	nmof	NOUN
ijpds-3935	236	19	nanocomposite	nanocomposite	PROPN
ijpds-3935	236	20	encapsulated	encapsulate	VERB
ijpds-3935	236	21	with	with	ADP
ijpds-3935	236	22	gambogic	gambogic	NOUN
ijpds-3935	236	23	acid	acid	NOUN
ijpds-3935	236	24	.	.	PUNCT
ijpds-3935	237	1	journal	journal	PROPN
ijpds-3935	237	2	of	of	ADP
ijpds-3935	237	3	nanobiotechnology	nanobiotechnology	NOUN
ijpds-3935	237	4	.	.	PUNCT
ijpds-3935	238	1	2022	2022	NUM
ijpds-3935	238	2	dec;20(1):1	dec;20(1):1	PROPN
ijpds-3935	238	3	-	-	PUNCT
ijpds-3935	238	4	22	22	NUM
ijpds-3935	238	5	.	.	PUNCT
ijpds-3935	239	1	31	31	NUM
ijpds-3935	239	2	.	.	PUNCT
ijpds-3935	240	1	gandhi	gandhi	PROPN
ijpds-3935	240	2	ns	ns	NUM
ijpds-3935	240	3	,	,	PUNCT
ijpds-3935	240	4	tekade	tekade	VERB
ijpds-3935	240	5	rk	rk	NOUN
ijpds-3935	240	6	,	,	PUNCT
ijpds-3935	240	7	chougule	chougule	NOUN
ijpds-3935	240	8	mb	mb	PROPN
ijpds-3935	240	9	.	.	PROPN
ijpds-3935	240	10	nanocarrier	nanocarrier	NOUN
ijpds-3935	240	11	mediated	mediate	VERB
ijpds-3935	240	12	delivery	delivery	NOUN
ijpds-3935	240	13	of	of	ADP
ijpds-3935	240	14	sirna	sirna	PROPN
ijpds-3935	240	15	/	/	SYM
ijpds-3935	240	16	mirna	mirna	PROPN
ijpds-3935	240	17	in	in	ADP
ijpds-3935	240	18	combination	combination	NOUN
ijpds-3935	240	19	with	with	ADP
ijpds-3935	240	20	chemotherapeutic	chemotherapeutic	ADJ
ijpds-3935	240	21	agents	agent	NOUN
ijpds-3935	240	22	for	for	ADP
ijpds-3935	240	23	cancer	cancer	NOUN
ijpds-3935	240	24	therapy	therapy	NOUN
ijpds-3935	240	25	:	:	PUNCT
ijpds-3935	240	26	current	current	ADJ
ijpds-3935	240	27	progress	progress	NOUN
ijpds-3935	240	28	and	and	CCONJ
ijpds-3935	240	29	advances	advance	NOUN
ijpds-3935	240	30	.	.	PUNCT
ijpds-3935	241	1	journal	journal	PROPN
ijpds-3935	241	2	of	of	ADP
ijpds-3935	241	3	controlled	control	VERB
ijpds-3935	241	4	release	release	NOUN
ijpds-3935	241	5	.	.	PUNCT
ijpds-3935	242	1	2014	2014	NUM
ijpds-3935	242	2	nov	nov	NOUN
ijpds-3935	242	3	28	28	NUM
ijpds-3935	242	4	;	;	PUNCT
ijpds-3935	242	5	194:238	194:238	NUM
ijpds-3935	242	6	-	-	SYM
ijpds-3935	242	7	56	56	NUM
ijpds-3935	242	8	.	.	PUNCT
ijpds-3935	242	9	32	32	NUM
ijpds-3935	242	10	.	.	PUNCT
ijpds-3935	243	1	hu	hu	PROPN
ijpds-3935	243	2	b	b	PROPN
ijpds-3935	243	3	,	,	PUNCT
ijpds-3935	243	4	zhong	zhong	PROPN
ijpds-3935	243	5	l	l	PROPN
ijpds-3935	243	6	,	,	PUNCT
ijpds-3935	243	7	weng	weng	PROPN
ijpds-3935	243	8	y	y	PROPN
ijpds-3935	243	9	,	,	PUNCT
ijpds-3935	243	10	et	et	PROPN
ijpds-3935	243	11	al	al	PROPN
ijpds-3935	243	12	.	.	PUNCT
ijpds-3935	244	1	therapeutic	therapeutic	PROPN
ijpds-3935	244	2	sirna	sirna	PROPN
ijpds-3935	244	3	:	:	PUNCT
ijpds-3935	244	4	state	state	NOUN
ijpds-3935	244	5	of	of	ADP
ijpds-3935	244	6	the	the	DET
ijpds-3935	244	7	art	art	NOUN
ijpds-3935	244	8	.	.	PUNCT
ijpds-3935	245	1	signal	signal	ADJ
ijpds-3935	245	2	transduction	transduction	NOUN
ijpds-3935	245	3	and	and	CCONJ
ijpds-3935	245	4	targeted	target	VERB
ijpds-3935	245	5	therapy	therapy	NOUN
ijpds-3935	245	6	.	.	PUNCT
ijpds-3935	246	1	2020	2020	NUM
ijpds-3935	246	2	jun	jun	PROPN
ijpds-3935	246	3	19;5(1):101	19;5(1):101	NUM
ijpds-3935	246	4	.	.	PUNCT
ijpds-3935	247	1	33	33	NUM
ijpds-3935	247	2	.	.	PUNCT
ijpds-3935	248	1	angart	angart	PROPN
ijpds-3935	248	2	p	p	NOUN
ijpds-3935	248	3	,	,	PUNCT
ijpds-3935	248	4	vocelle	vocelle	NOUN
ijpds-3935	248	5	d	d	PROPN
ijpds-3935	248	6	,	,	PUNCT
ijpds-3935	248	7	chan	chan	PROPN
ijpds-3935	248	8	c	c	PROPN
ijpds-3935	248	9	,	,	PUNCT
ijpds-3935	248	10	et	et	PROPN
ijpds-3935	248	11	al	al	PROPN
ijpds-3935	248	12	.	.	PUNCT
ijpds-3935	249	1	design	design	NOUN
ijpds-3935	249	2	of	of	ADP
ijpds-3935	249	3	sirna	sirna	PROPN
ijpds-3935	249	4	therapeutics	therapeutic	NOUN
ijpds-3935	249	5	from	from	ADP
ijpds-3935	249	6	the	the	DET
ijpds-3935	249	7	molecular	molecular	ADJ
ijpds-3935	249	8	scale	scale	NOUN
ijpds-3935	249	9	.	.	PUNCT
ijpds-3935	250	1	pharmaceuticals	pharmaceutical	NOUN
ijpds-3935	250	2	.	.	PUNCT
ijpds-3935	251	1	2013	2013	NUM
ijpds-3935	251	2	;	;	PUNCT
ijpds-3935	251	3	25;6(4):440	25;6(4):440	NUM
ijpds-3935	251	4	-	-	SYM
ijpds-3935	251	5	68	68	NUM
ijpds-3935	251	6	.	.	PUNCT
ijpds-3935	252	1	34	34	NUM
ijpds-3935	252	2	.	.	PUNCT
ijpds-3935	252	3	mansoori	mansoori	PROPN
ijpds-3935	252	4	b	b	PROPN
ijpds-3935	252	5	,	,	PUNCT
ijpds-3935	252	6	mohammadi	mohammadi	NOUN
ijpds-3935	252	7	a	a	X
ijpds-3935	252	8	,	,	PUNCT
ijpds-3935	252	9	davudian	davudian	PROPN
ijpds-3935	252	10	s	s	PROPN
ijpds-3935	252	11	,	,	PUNCT
ijpds-3935	252	12	et	et	PROPN
ijpds-3935	252	13	al	al	PROPN
ijpds-3935	252	14	.	.	PUNCT
ijpds-3935	253	1	the	the	DET
ijpds-3935	253	2	different	different	ADJ
ijpds-3935	253	3	mechanisms	mechanism	NOUN
ijpds-3935	253	4	of	of	ADP
ijpds-3935	253	5	cancer	cancer	NOUN
ijpds-3935	253	6	drug	drug	NOUN
ijpds-3935	253	7	resistance	resistance	NOUN
ijpds-3935	253	8	:	:	PUNCT
ijpds-3935	253	9	a	a	DET
ijpds-3935	253	10	brief	brief	ADJ
ijpds-3935	253	11	review	review	NOUN
ijpds-3935	253	12	.	.	PUNCT
ijpds-3935	254	1	advanced	advanced	ADJ
ijpds-3935	254	2	pharmaceutical	pharmaceutical	ADJ
ijpds-3935	254	3	bulletin	bulletin	NOUN
ijpds-3935	254	4	.	.	PUNCT
ijpds-3935	255	1	2017	2017	NUM
ijpds-3935	255	2	sep;7(3):339	sep;7(3):339	PROPN
ijpds-3935	255	3	.	.	PROPN
ijpds-3935	255	4	35	35	NUM
ijpds-3935	255	5	.	.	PUNCT
ijpds-3935	256	1	lee	lee	PROPN
ijpds-3935	256	2	j	j	PROPN
ijpds-3935	256	3	-	-	PROPN
ijpds-3935	256	4	m	m	PROPN
ijpds-3935	256	5	,	,	PUNCT
ijpds-3935	256	6	yoon	yoon	PROPN
ijpds-3935	256	7	t	t	PROPN
ijpds-3935	256	8	-	-	PUNCT
ijpds-3935	256	9	j	j	PROPN
ijpds-3935	256	10	,	,	PUNCT
ijpds-3935	256	11	cho	cho	PROPN
ijpds-3935	256	12	y	y	PROPN
ijpds-3935	256	13	-	-	PUNCT
ijpds-3935	256	14	s.	s.	PROPN
ijpds-3935	256	15	recent	recent	ADJ
ijpds-3935	256	16	developments	development	NOUN
ijpds-3935	256	17	in	in	ADP
ijpds-3935	256	18	nanoparticle	nanoparticle	NOUN
ijpds-3935	256	19	-	-	PUNCT
ijpds-3935	256	20	based	base	VERB
ijpds-3935	256	21	sirna	sirna	PROPN
ijpds-3935	256	22	delivery	delivery	NOUN
ijpds-3935	256	23	for	for	ADP
ijpds-3935	256	24	cancer	cancer	NOUN
ijpds-3935	256	25	therapy	therapy	NOUN
ijpds-3935	256	26	.	.	PUNCT
ijpds-3935	257	1	biomed	biome	VERB
ijpds-3935	257	2	research	research	NOUN
ijpds-3935	257	3	international	international	PROPN
ijpds-3935	257	4	.	.	PUNCT
ijpds-3935	258	1	2013	2013	NUM
ijpds-3935	258	2	;	;	PUNCT
ijpds-3935	258	3	2013:1–10	2013:1–10	NUM
ijpds-3935	258	4	.	.	NOUN
ijpds-3935	258	5	36	36	NUM
ijpds-3935	258	6	.	.	PUNCT
ijpds-3935	259	1	zhang	zhang	PROPN
ijpds-3935	259	2	mm	mm	PROPN
ijpds-3935	259	3	,	,	PUNCT
ijpds-3935	259	4	bahal	bahal	PROPN
ijpds-3935	259	5	r	r	NOUN
ijpds-3935	259	6	,	,	PUNCT
ijpds-3935	259	7	rasmussen	rasmussen	PROPN
ijpds-3935	259	8	tp	tp	PROPN
ijpds-3935	259	9	,	,	PUNCT
ijpds-3935	259	10	et	et	PROPN
ijpds-3935	259	11	al	al	PROPN
ijpds-3935	259	12	.	.	PUNCT
ijpds-3935	260	1	the	the	DET
ijpds-3935	260	2	growth	growth	NOUN
ijpds-3935	260	3	of	of	ADP
ijpds-3935	260	4	sirnabased	sirnabase	VERB
ijpds-3935	260	5	therapeutics	therapeutic	NOUN
ijpds-3935	260	6	:	:	PUNCT
ijpds-3935	260	7	updated	update	VERB
ijpds-3935	260	8	clinical	clinical	ADJ
ijpds-3935	260	9	studies	study	NOUN
ijpds-3935	260	10	.	.	PUNCT
ijpds-3935	261	1	biochemical	biochemical	ADJ
ijpds-3935	261	2	pharmacology	pharmacology	NOUN
ijpds-3935	261	3	.	.	PUNCT
ijpds-3935	262	1	2021	2021	NUM
ijpds-3935	262	2	jul	jul	PROPN
ijpds-3935	262	3	1	1	NUM
ijpds-3935	262	4	;	;	PUNCT
ijpds-3935	262	5	189:114432	189:114432	NUM
ijpds-3935	262	6	.	.	PROPN
ijpds-3935	262	7	37	37	NUM
ijpds-3935	262	8	.	.	PUNCT
ijpds-3935	263	1	huang	huang	PROPN
ijpds-3935	263	2	c	c	PROPN
ijpds-3935	263	3	,	,	PUNCT
ijpds-3935	263	4	li	li	PROPN
ijpds-3935	263	5	m	m	PROPN
ijpds-3935	263	6	,	,	PUNCT
ijpds-3935	263	7	chen	chen	PROPN
ijpds-3935	263	8	c	c	PROPN
ijpds-3935	263	9	,	,	PUNCT
ijpds-3935	263	10	et	et	PROPN
ijpds-3935	263	11	al	al	PROPN
ijpds-3935	263	12	.	.	PROPN
ijpds-3935	264	1	small	small	ADJ
ijpds-3935	264	2	interfering	interfere	VERB
ijpds-3935	264	3	rna	rna	NOUN
ijpds-3935	264	4	therapy	therapy	NOUN
ijpds-3935	264	5	in	in	ADP
ijpds-3935	264	6	cancer	cancer	NOUN
ijpds-3935	264	7	:	:	PUNCT
ijpds-3935	264	8	mechanism	mechanism	NOUN
ijpds-3935	264	9	,	,	PUNCT
ijpds-3935	264	10	potential	potential	ADJ
ijpds-3935	264	11	targets	target	NOUN
ijpds-3935	264	12	,	,	PUNCT
ijpds-3935	264	13	and	and	CCONJ
ijpds-3935	264	14	clinical	clinical	ADJ
ijpds-3935	264	15	applications	application	NOUN
ijpds-3935	264	16	.	.	PUNCT
ijpds-3935	265	1	expert	expert	ADJ
ijpds-3935	265	2	opinion	opinion	NOUN
ijpds-3935	265	3	on	on	ADP
ijpds-3935	265	4	therapeutic	therapeutic	ADJ
ijpds-3935	265	5	targets	target	NOUN
ijpds-3935	265	6	.	.	PUNCT
ijpds-3935	266	1	2008	2008	NUM
ijpds-3935	266	2	may	may	AUX
ijpds-3935	266	3	1;12(5):637	1;12(5):637	NUM
ijpds-3935	266	4	-	-	PUNCT
ijpds-3935	266	5	45	45	NUM
ijpds-3935	266	6	.	.	PUNCT
ijpds-3935	267	1	38	38	NUM
ijpds-3935	267	2	.	.	PUNCT
ijpds-3935	268	1	raguraman	raguraman	ADJ
ijpds-3935	268	2	r	r	NOUN
ijpds-3935	268	3	,	,	PUNCT
ijpds-3935	268	4	shanmugarama	shanmugarama	NOUN
ijpds-3935	268	5	s	s	PART
ijpds-3935	268	6	,	,	PUNCT
ijpds-3935	268	7	mehta	mehta	PROPN
ijpds-3935	268	8	m	m	PROPN
ijpds-3935	268	9	,	,	PUNCT
ijpds-3935	268	10	et	et	PROPN
ijpds-3935	268	11	al	al	PROPN
ijpds-3935	268	12	.	.	PROPN
ijpds-3935	268	13	drug	drug	NOUN
ijpds-3935	268	14	delivery	delivery	NOUN
ijpds-3935	268	15	approaches	approach	NOUN
ijpds-3935	268	16	for	for	ADP
ijpds-3935	268	17	hur	hur	NOUN
ijpds-3935	268	18	-	-	PUNCT
ijpds-3935	268	19	targeted	target	VERB
ijpds-3935	268	20	therapy	therapy	NOUN
ijpds-3935	268	21	for	for	ADP
ijpds-3935	268	22	lung	lung	NOUN
ijpds-3935	268	23	cancer	cancer	NOUN
ijpds-3935	268	24	.	.	PUNCT
ijpds-3935	269	1	advanced	advanced	ADJ
ijpds-3935	269	2	drug	drug	NOUN
ijpds-3935	269	3	delivery	delivery	NOUN
ijpds-3935	269	4	reviews	review	NOUN
ijpds-3935	269	5	.	.	PUNCT
ijpds-3935	270	1	2022	2022	NUM
ijpds-3935	270	2	jan	jan	PROPN
ijpds-3935	270	3	1	1	NUM
ijpds-3935	270	4	;	;	PUNCT
ijpds-3935	270	5	180:114068	180:114068	NUM
ijpds-3935	270	6	.	.	NOUN
ijpds-3935	270	7	39	39	NUM
ijpds-3935	270	8	.	.	PUNCT
ijpds-3935	271	1	ho	ho	PROPN
ijpds-3935	271	2	d	d	PROPN
ijpds-3935	271	3	,	,	PUNCT
ijpds-3935	271	4	quake	quake	PROPN
ijpds-3935	271	5	sr	sr	PROPN
ijpds-3935	271	6	,	,	PUNCT
ijpds-3935	271	7	mccabe	mccabe	PROPN
ijpds-3935	271	8	er	er	INTJ
ijpds-3935	271	9	,	,	PUNCT
ijpds-3935	271	10	et	et	PROPN
ijpds-3935	271	11	al	al	PROPN
ijpds-3935	271	12	.	.	PROPN
ijpds-3935	271	13	enabling	enable	VERB
ijpds-3935	271	14	technologies	technology	NOUN
ijpds-3935	271	15	for	for	ADP
ijpds-3935	271	16	personalized	personalized	ADJ
ijpds-3935	271	17	and	and	CCONJ
ijpds-3935	271	18	precision	precision	NOUN
ijpds-3935	271	19	medicine	medicine	NOUN
ijpds-3935	271	20	.	.	PUNCT
ijpds-3935	272	1	trends	trend	NOUN
ijpds-3935	272	2	in	in	ADP
ijpds-3935	272	3	biotechnology	biotechnology	NOUN
ijpds-3935	272	4	.	.	PUNCT
ijpds-3935	273	1	2020	2020	NUM
ijpds-3935	273	2	may	may	AUX
ijpds-3935	273	3	1;38(5):497	1;38(5):497	NUM
ijpds-3935	273	4	-	-	SYM
ijpds-3935	273	5	518	518	NUM
ijpds-3935	273	6	.	.	NUM
ijpds-3935	274	1	40	40	NUM
ijpds-3935	274	2	.	.	PUNCT
ijpds-3935	275	1	ozpolat	ozpolat	PROPN
ijpds-3935	275	2	b	b	PROPN
ijpds-3935	275	3	,	,	PUNCT
ijpds-3935	275	4	sood	sood	PROPN
ijpds-3935	275	5	ak	ak	PROPN
ijpds-3935	275	6	,	,	PUNCT
ijpds-3935	275	7	lopez	lopez	NOUN
ijpds-3935	275	8	-	-	PUNCT
ijpds-3935	275	9	berestein	berestein	PROPN
ijpds-3935	275	10	g.	g.	PROPN
ijpds-3935	275	11	liposomal	liposomal	PROPN
ijpds-3935	275	12	sirna	sirna	PROPN
ijpds-3935	275	13	nanocarriers	nanocarrier	VERB
ijpds-3935	275	14	for	for	ADP
ijpds-3935	275	15	cancer	cancer	NOUN
ijpds-3935	275	16	therapy	therapy	NOUN
ijpds-3935	275	17	.	.	PUNCT
ijpds-3935	276	1	advanced	advanced	ADJ
ijpds-3935	276	2	drug	drug	NOUN
ijpds-3935	276	3	delivery	delivery	NOUN
ijpds-3935	276	4	reviews	review	NOUN
ijpds-3935	276	5	.	.	PUNCT
ijpds-3935	277	1	2014	2014	NUM
ijpds-3935	277	2	feb	feb	NOUN
ijpds-3935	277	3	1	1	NUM
ijpds-3935	277	4	;	;	PUNCT
ijpds-3935	277	5	66:110	66:110	PROPN
ijpds-3935	277	6	-	-	SYM
ijpds-3935	277	7	6	6	NUM
ijpds-3935	277	8	.	.	NOUN
ijpds-3935	277	9	41	41	NUM
ijpds-3935	277	10	.	.	PUNCT
ijpds-3935	278	1	meade	meade	PROPN
ijpds-3935	278	2	br	br	PROPN
ijpds-3935	278	3	,	,	PUNCT
ijpds-3935	278	4	dowdy	dowdy	ADJ
ijpds-3935	278	5	sf	sf	PROPN
ijpds-3935	278	6	.	.	PUNCT
ijpds-3935	278	7	exogenous	exogenous	PROPN
ijpds-3935	278	8	sirna	sirna	PROPN
ijpds-3935	278	9	delivery	delivery	NOUN
ijpds-3935	278	10	using	use	VERB
ijpds-3935	278	11	peptide	peptide	ADJ
ijpds-3935	278	12	transduction	transduction	NOUN
ijpds-3935	278	13	domains	domain	NOUN
ijpds-3935	278	14	/	/	SYM
ijpds-3935	278	15	cell	cell	NOUN
ijpds-3935	278	16	penetrating	penetrate	VERB
ijpds-3935	278	17	peptides	peptide	NOUN
ijpds-3935	278	18	.	.	PUNCT
ijpds-3935	279	1	advanced	advanced	ADJ
ijpds-3935	279	2	drug	drug	NOUN
ijpds-3935	279	3	delivery	delivery	NOUN
ijpds-3935	279	4	reviews	review	NOUN
ijpds-3935	279	5	.	.	PUNCT
ijpds-3935	280	1	2007	2007	NUM
ijpds-3935	280	2	mar	mar	PROPN
ijpds-3935	280	3	30;59(2	30;59(2	PROPN
ijpds-3935	280	4	-	-	PUNCT
ijpds-3935	280	5	3):134	3):134	NUM
ijpds-3935	280	6	-	-	PUNCT
ijpds-3935	280	7	40	40	NUM
ijpds-3935	280	8	.	.	PUNCT
ijpds-3935	280	9	42	42	NUM
ijpds-3935	280	10	.	.	PUNCT
ijpds-3935	281	1	senthil	senthil	PROPN
ijpds-3935	281	2	-	-	PUNCT
ijpds-3935	281	3	kumar	kumar	PROPN
ijpds-3935	281	4	m	m	PROPN
ijpds-3935	281	5	,	,	PUNCT
ijpds-3935	281	6	mysore	mysore	PROPN
ijpds-3935	281	7	ks	ks	PROPN
ijpds-3935	281	8	.	.	PROPN
ijpds-3935	281	9	caveat	caveat	PROPN
ijpds-3935	281	10	of	of	ADP
ijpds-3935	281	11	rnai	rnai	PROPN
ijpds-3935	281	12	in	in	ADP
ijpds-3935	281	13	plants	plant	NOUN
ijpds-3935	281	14	:	:	PUNCT
ijpds-3935	281	15	the	the	DET
ijpds-3935	281	16	offtarget	offtarget	NOUN
ijpds-3935	281	17	effect	effect	NOUN
ijpds-3935	281	18	.	.	PUNCT
ijpds-3935	282	1	rnai	rnai	PROPN
ijpds-3935	282	2	and	and	CCONJ
ijpds-3935	282	3	plant	plant	NOUN
ijpds-3935	282	4	gene	gene	NOUN
ijpds-3935	282	5	function	function	NOUN
ijpds-3935	282	6	analysis	analysis	NOUN
ijpds-3935	282	7	:	:	PUNCT
ijpds-3935	282	8	methods	method	NOUN
ijpds-3935	282	9	and	and	CCONJ
ijpds-3935	282	10	protocols	protocol	NOUN
ijpds-3935	282	11	.	.	PUNCT
ijpds-3935	283	1	2011:13	2011:13	NUM
ijpds-3935	283	2	-	-	SYM
ijpds-3935	283	3	25	25	NUM
ijpds-3935	283	4	.	.	PUNCT
ijpds-3935	284	1	43	43	NUM
ijpds-3935	284	2	.	.	PUNCT
ijpds-3935	285	1	zhang	zhang	PROPN
ijpds-3935	285	2	mm	mm	PROPN
ijpds-3935	285	3	,	,	PUNCT
ijpds-3935	285	4	bahal	bahal	PROPN
ijpds-3935	285	5	r	r	NOUN
ijpds-3935	285	6	,	,	PUNCT
ijpds-3935	285	7	rasmussen	rasmussen	PROPN
ijpds-3935	285	8	tp	tp	PROPN
ijpds-3935	285	9	,	,	PUNCT
ijpds-3935	285	10	et	et	PROPN
ijpds-3935	285	11	al	al	PROPN
ijpds-3935	285	12	.	.	PUNCT
ijpds-3935	286	1	the	the	DET
ijpds-3935	286	2	growth	growth	NOUN
ijpds-3935	286	3	of	of	ADP
ijpds-3935	286	4	sirnabased	sirnabase	VERB
ijpds-3935	286	5	therapeutics	therapeutic	NOUN
ijpds-3935	286	6	:	:	PUNCT
ijpds-3935	286	7	updated	update	VERB
ijpds-3935	286	8	clinical	clinical	ADJ
ijpds-3935	286	9	studies	study	NOUN
ijpds-3935	286	10	.	.	PUNCT
ijpds-3935	287	1	biochemical	biochemical	ADJ
ijpds-3935	287	2	pharmacology	pharmacology	NOUN
ijpds-3935	287	3	.	.	PUNCT
ijpds-3935	288	1	2021	2021	NUM
ijpds-3935	288	2	jul	jul	PROPN
ijpds-3935	288	3	1	1	NUM
ijpds-3935	288	4	;	;	PUNCT
ijpds-3935	288	5	189:114432	189:114432	NUM
ijpds-3935	288	6	.	.	PROPN
ijpds-3935	288	7	44	44	NUM
ijpds-3935	288	8	.	.	PUNCT
ijpds-3935	289	1	iversen	iversen	PROPN
ijpds-3935	289	2	f	f	PROPN
ijpds-3935	289	3	,	,	PUNCT
ijpds-3935	289	4	yang	yang	PROPN
ijpds-3935	289	5	c	c	PROPN
ijpds-3935	289	6	,	,	PUNCT
ijpds-3935	289	7	dagnæs	dagnæs	NOUN
ijpds-3935	289	8	-	-	PUNCT
ijpds-3935	289	9	hansen	hansen	PROPN
ijpds-3935	289	10	f	f	PROPN
ijpds-3935	289	11	,	,	PUNCT
ijpds-3935	289	12	et	et	PROPN
ijpds-3935	289	13	al	al	PROPN
ijpds-3935	289	14	.	.	PROPN
ijpds-3935	289	15	optimized	optimize	VERB
ijpds-3935	289	16	sirnapeg	sirnapeg	NOUN
ijpds-3935	289	17	conjugates	conjugate	NOUN
ijpds-3935	289	18	for	for	ADP
ijpds-3935	289	19	extended	extended	ADJ
ijpds-3935	289	20	blood	blood	NOUN
ijpds-3935	289	21	circulation	circulation	NOUN
ijpds-3935	289	22	and	and	CCONJ
ijpds-3935	289	23	reduced	reduce	VERB
ijpds-3935	289	24	urine	urine	NOUN
ijpds-3935	289	25	excretion	excretion	NOUN
ijpds-3935	289	26	in	in	ADP
ijpds-3935	289	27	mice	mouse	NOUN
ijpds-3935	289	28	.	.	PUNCT
ijpds-3935	290	1	theranostics	theranostic	NOUN
ijpds-3935	290	2	.	.	PUNCT
ijpds-3935	291	1	2013;3(3):201	2013;3(3):201	NUM
ijpds-3935	291	2	-	-	SYM
ijpds-3935	291	3	2	2	NUM
ijpds-3935	291	4	.	.	PUNCT
ijpds-3935	292	1	how	how	SCONJ
ijpds-3935	292	2	to	to	PART
ijpds-3935	292	3	cite	cite	VERB
ijpds-3935	292	4	this	this	DET
ijpds-3935	292	5	article	article	NOUN
ijpds-3935	292	6	:	:	PUNCT
ijpds-3935	292	7	preeti	preeti	PROPN
ijpds-3935	292	8	shanbhag	shanbhag	PROPN
ijpds-3935	292	9	,	,	PUNCT
ijpds-3935	292	10	ramdas	ramdas	PROPN
ijpds-3935	292	11	bhat	bhat	PROPN
ijpds-3935	292	12	,	,	PUNCT
ijpds-3935	292	13	a	a	DET
ijpds-3935	292	14	r	r	NOUN
ijpds-3935	292	15	shabaraya	shabaraya	NOUN
ijpds-3935	292	16	.	.	PUNCT
ijpds-3935	293	1	the	the	DET
ijpds-3935	293	2	potential	potential	NOUN
ijpds-3935	293	3	of	of	ADP
ijpds-3935	293	4	sirna	sirna	PROPN
ijpds-3935	293	5	-	-	PUNCT
ijpds-3935	293	6	mediated	mediate	VERB
ijpds-3935	293	7	oncogene	oncogene	NOUN
ijpds-3935	293	8	silencing	silence	VERB
ijpds-3935	293	9	in	in	ADP
ijpds-3935	293	10	cancer	cancer	NOUN
ijpds-3935	293	11	therapy	therapy	NOUN
ijpds-3935	293	12	:	:	PUNCT
ijpds-3935	293	13	an	an	DET
ijpds-3935	293	14	overview	overview	NOUN
ijpds-3935	293	15	of	of	ADP
ijpds-3935	293	16	pharmacogenomics	pharmacogenomic	NOUN
ijpds-3935	293	17	strategies	strategy	NOUN
ijpds-3935	293	18	.	.	PUNCT
ijpds-3935	294	1	indian	indian	PROPN
ijpds-3935	294	2	j	j	PROPN
ijpds-3935	294	3	pharm	pharm	PROPN
ijpds-3935	294	4	drug	drug	PROPN
ijpds-3935	294	5	studies	study	NOUN
ijpds-3935	294	6	.	.	PUNCT
ijpds-3935	295	1	2023	2023	NUM
ijpds-3935	295	2	:	:	PUNCT
ijpds-3935	295	3	2(2	2(2	NUM
ijpds-3935	295	4	)	)	PUNCT
ijpds-3935	295	5	63	63	NUM
ijpds-3935	295	6	-	-	SYM
ijpds-3935	295	7	68	68	NUM
ijpds-3935	295	8	.	.	PUNCT
ijpds-3935	296	1	funding	funding	NOUN
ijpds-3935	296	2	:	:	PUNCT
ijpds-3935	296	3	none	none	NOUN
ijpds-3935	296	4	conflict	conflict	NOUN
ijpds-3935	296	5	of	of	ADP
ijpds-3935	296	6	interest	interest	NOUN
ijpds-3935	296	7	:	:	PUNCT
ijpds-3935	296	8	none	none	NOUN
ijpds-3935	296	9	stated	state	VERB