id	sid	tid	token	lemma	pos
ijpds-4459	1	1	bhat	bhat	PROPN
ijpds-4459	1	2	&	&	CCONJ
ijpds-4459	1	3	shanbhag	shanbhag	NOUN
ijpds-4459	1	4	biomaterials	biomaterial	NOUN
ijpds-4459	1	5	:	:	PUNCT
ijpds-4459	1	6	revolutionizing	revolutionize	VERB
ijpds-4459	1	7	cancer	cancer	NOUN
ijpds-4459	1	8	immunotherapy	immunotherapy	NOUN
ijpds-4459	1	9	and	and	CCONJ
ijpds-4459	1	10	genomics	genomics	NOUN
ijpds-4459	1	11	vol	vol	NOUN
ijpds-4459	1	12	3	3	NUM
ijpds-4459	1	13	|	|	NOUN
ijpds-4459	1	14	issue	issue	NOUN
ijpds-4459	1	15	2	2	NUM
ijpds-4459	1	16	|	|	ADV
ijpds-4459	1	17	apr	apr	NOUN
ijpds-4459	1	18	–	–	PUNCT
ijpds-4459	1	19	jun	jun	PROPN
ijpds-4459	1	20	2024	2024	NUM
ijpds-4459	1	21	indian	indian	PROPN
ijpds-4459	1	22	j	j	PROPN
ijpds-4459	1	23	pharm	pharm	PROPN
ijpds-4459	1	24	drug	drug	PROPN
ijpds-4459	1	25	studies	study	NOUN
ijpds-4459	1	26	|	|	ADV
ijpds-4459	1	27	37	37	NUM
ijpds-4459	1	28	review	review	NOUN
ijpds-4459	1	29	article	article	NOUN
ijpds-4459	1	30	emerging	emerge	VERB
ijpds-4459	1	31	trends	trend	NOUN
ijpds-4459	1	32	in	in	ADP
ijpds-4459	1	33	biomaterials	biomaterial	NOUN
ijpds-4459	1	34	for	for	ADP
ijpds-4459	1	35	cancer	cancer	NOUN
ijpds-4459	1	36	immunotherapy	immunotherapy	NOUN
ijpds-4459	1	37	and	and	CCONJ
ijpds-4459	1	38	genome	genome	NOUN
ijpds-4459	1	39	editing	editing	NOUN
ijpds-4459	1	40	:	:	PUNCT
ijpds-4459	1	41	a	a	DET
ijpds-4459	1	42	comprehensive	comprehensive	ADJ
ijpds-4459	1	43	review	review	NOUN
ijpds-4459	1	44	ramdas	ramdas	PROPN
ijpds-4459	1	45	bhat1	bhat1	PROPN
ijpds-4459	1	46	,	,	PUNCT
ijpds-4459	1	47	preeti	preeti	PROPN
ijpds-4459	1	48	shanbhag2	shanbhag2	PROPN
ijpds-4459	1	49	from	from	ADP
ijpds-4459	1	50	,	,	PUNCT
ijpds-4459	1	51	1associate	1associate	NUM
ijpds-4459	1	52	professor	professor	NOUN
ijpds-4459	1	53	,	,	PUNCT
ijpds-4459	1	54	2pg	2pg	ADJ
ijpds-4459	1	55	scholar	scholar	NOUN
ijpds-4459	1	56	,	,	PUNCT
ijpds-4459	1	57	department	department	NOUN
ijpds-4459	1	58	of	of	ADP
ijpds-4459	1	59	pharmacology	pharmacology	NOUN
ijpds-4459	1	60	,	,	PUNCT
ijpds-4459	1	61	srinivas	srinivas	PROPN
ijpds-4459	1	62	college	college	PROPN
ijpds-4459	1	63	of	of	ADP
ijpds-4459	1	64	pharmacy	pharmacy	NOUN
ijpds-4459	1	65	,	,	PUNCT
ijpds-4459	1	66	valachil	valachil	NOUN
ijpds-4459	1	67	,	,	PUNCT
ijpds-4459	1	68	post	post	NOUN
ijpds-4459	1	69	farangipete	farangipete	NOUN
ijpds-4459	1	70	,	,	PUNCT
ijpds-4459	1	71	mangalore	mangalore	PROPN
ijpds-4459	1	72	,	,	PUNCT
ijpds-4459	1	73	karnataka	karnataka	PROPN
ijpds-4459	1	74	,	,	PUNCT
ijpds-4459	1	75	india	india	PROPN
ijpds-4459	1	76	.	.	PUNCT
ijpds-4459	2	1	abstract	abstract	ADJ
ijpds-4459	2	2	this	this	DET
ijpds-4459	2	3	detailed	detailed	ADJ
ijpds-4459	2	4	review	review	NOUN
ijpds-4459	2	5	navigates	navigate	VERB
ijpds-4459	2	6	the	the	DET
ijpds-4459	2	7	dynamic	dynamic	ADJ
ijpds-4459	2	8	landscape	landscape	NOUN
ijpds-4459	2	9	of	of	ADP
ijpds-4459	2	10	cancer	cancer	NOUN
ijpds-4459	2	11	therapeutics	therapeutic	NOUN
ijpds-4459	2	12	,	,	PUNCT
ijpds-4459	2	13	shifting	shift	VERB
ijpds-4459	2	14	focus	focus	NOUN
ijpds-4459	2	15	from	from	ADP
ijpds-4459	2	16	conventional	conventional	ADJ
ijpds-4459	2	17	approaches	approach	NOUN
ijpds-4459	2	18	to	to	ADP
ijpds-4459	2	19	the	the	DET
ijpds-4459	2	20	promising	promising	ADJ
ijpds-4459	2	21	frontiers	frontier	NOUN
ijpds-4459	2	22	of	of	ADP
ijpds-4459	2	23	immunotherapy	immunotherapy	NOUN
ijpds-4459	2	24	and	and	CCONJ
ijpds-4459	2	25	genome	genome	NOUN
ijpds-4459	2	26	editing	editing	NOUN
ijpds-4459	2	27	.	.	PUNCT
ijpds-4459	3	1	biomaterials	biomaterial	NOUN
ijpds-4459	3	2	,	,	PUNCT
ijpds-4459	3	3	including	include	VERB
ijpds-4459	3	4	nanoparticles	nanoparticle	NOUN
ijpds-4459	3	5	and	and	CCONJ
ijpds-4459	3	6	hydrogels	hydrogel	NOUN
ijpds-4459	3	7	,	,	PUNCT
ijpds-4459	3	8	are	be	AUX
ijpds-4459	3	9	scrutinized	scrutinize	VERB
ijpds-4459	3	10	for	for	ADP
ijpds-4459	3	11	their	their	PRON
ijpds-4459	3	12	role	role	NOUN
ijpds-4459	3	13	in	in	ADP
ijpds-4459	3	14	enhancing	enhance	VERB
ijpds-4459	3	15	therapeutic	therapeutic	ADJ
ijpds-4459	3	16	efficacy	efficacy	NOUN
ijpds-4459	3	17	across	across	ADP
ijpds-4459	3	18	various	various	ADJ
ijpds-4459	3	19	cancer	cancer	NOUN
ijpds-4459	3	20	types	type	NOUN
ijpds-4459	3	21	.	.	PUNCT
ijpds-4459	4	1	breakthroughs	breakthrough	NOUN
ijpds-4459	4	2	in	in	ADP
ijpds-4459	4	3	biomaterial	biomaterial	ADJ
ijpds-4459	4	4	-	-	PUNCT
ijpds-4459	4	5	based	base	VERB
ijpds-4459	4	6	interventions	intervention	NOUN
ijpds-4459	4	7	are	be	AUX
ijpds-4459	4	8	emphasized	emphasize	VERB
ijpds-4459	4	9	,	,	PUNCT
ijpds-4459	4	10	with	with	ADP
ijpds-4459	4	11	a	a	DET
ijpds-4459	4	12	meticulous	meticulous	ADJ
ijpds-4459	4	13	examination	examination	NOUN
ijpds-4459	4	14	of	of	ADP
ijpds-4459	4	15	critical	critical	ADJ
ijpds-4459	4	16	methodological	methodological	ADJ
ijpds-4459	4	17	considerations	consideration	NOUN
ijpds-4459	4	18	,	,	PUNCT
ijpds-4459	4	19	such	such	ADJ
ijpds-4459	4	20	as	as	ADP
ijpds-4459	4	21	safety	safety	NOUN
ijpds-4459	4	22	,	,	PUNCT
ijpds-4459	4	23	biocompatibility	biocompatibility	NOUN
ijpds-4459	4	24	,	,	PUNCT
ijpds-4459	4	25	and	and	CCONJ
ijpds-4459	4	26	delivery	delivery	NOUN
ijpds-4459	4	27	efficiency	efficiency	NOUN
ijpds-4459	4	28	,	,	PUNCT
ijpds-4459	4	29	laying	lay	VERB
ijpds-4459	4	30	the	the	DET
ijpds-4459	4	31	groundwork	groundwork	NOUN
ijpds-4459	4	32	for	for	ADP
ijpds-4459	4	33	future	future	ADJ
ijpds-4459	4	34	research.the	research.the	DET
ijpds-4459	4	35	narrative	narrative	NOUN
ijpds-4459	4	36	emphasizes	emphasize	VERB
ijpds-4459	4	37	the	the	DET
ijpds-4459	4	38	need	need	NOUN
ijpds-4459	4	39	for	for	ADP
ijpds-4459	4	40	standardization	standardization	NOUN
ijpds-4459	4	41	and	and	CCONJ
ijpds-4459	4	42	regulatory	regulatory	ADJ
ijpds-4459	4	43	compliance	compliance	NOUN
ijpds-4459	4	44	to	to	PART
ijpds-4459	4	45	ensure	ensure	VERB
ijpds-4459	4	46	the	the	DET
ijpds-4459	4	47	safety	safety	NOUN
ijpds-4459	4	48	and	and	CCONJ
ijpds-4459	4	49	reliability	reliability	NOUN
ijpds-4459	4	50	of	of	ADP
ijpds-4459	4	51	emerging	emerge	VERB
ijpds-4459	4	52	therapies	therapy	NOUN
ijpds-4459	4	53	moving	move	VERB
ijpds-4459	4	54	towards	towards	ADP
ijpds-4459	4	55	clinical	clinical	ADJ
ijpds-4459	4	56	applications	application	NOUN
ijpds-4459	4	57	.	.	PUNCT
ijpds-4459	5	1	implications	implication	NOUN
ijpds-4459	5	2	for	for	ADP
ijpds-4459	5	3	theory	theory	NOUN
ijpds-4459	5	4	,	,	PUNCT
ijpds-4459	5	5	practice	practice	NOUN
ijpds-4459	5	6	,	,	PUNCT
ijpds-4459	5	7	and	and	CCONJ
ijpds-4459	5	8	future	future	ADJ
ijpds-4459	5	9	research	research	NOUN
ijpds-4459	5	10	highlight	highlight	VERB
ijpds-4459	5	11	the	the	DET
ijpds-4459	5	12	potential	potential	NOUN
ijpds-4459	5	13	of	of	ADP
ijpds-4459	5	14	biomaterial	biomaterial	NOUN
ijpds-4459	5	15	-	-	PUNCT
ijpds-4459	5	16	based	base	VERB
ijpds-4459	5	17	approaches	approach	NOUN
ijpds-4459	5	18	to	to	PART
ijpds-4459	5	19	offer	offer	VERB
ijpds-4459	5	20	safer	safe	ADJ
ijpds-4459	5	21	and	and	CCONJ
ijpds-4459	5	22	more	more	ADV
ijpds-4459	5	23	effective	effective	ADJ
ijpds-4459	5	24	cancer	cancer	NOUN
ijpds-4459	5	25	treatments	treatment	NOUN
ijpds-4459	5	26	.	.	PUNCT
ijpds-4459	6	1	the	the	DET
ijpds-4459	6	2	integration	integration	NOUN
ijpds-4459	6	3	of	of	ADP
ijpds-4459	6	4	personalized	personalized	ADJ
ijpds-4459	6	5	medicine	medicine	NOUN
ijpds-4459	6	6	is	be	AUX
ijpds-4459	6	7	advocated	advocate	VERB
ijpds-4459	6	8	,	,	PUNCT
ijpds-4459	6	9	emphasizing	emphasize	VERB
ijpds-4459	6	10	tailored	tailor	VERB
ijpds-4459	6	11	interventions	intervention	NOUN
ijpds-4459	6	12	based	base	VERB
ijpds-4459	6	13	on	on	ADP
ijpds-4459	6	14	individual	individual	ADJ
ijpds-4459	6	15	patient	patient	NOUN
ijpds-4459	6	16	profiles.the	profiles.the	DET
ijpds-4459	6	17	review	review	NOUN
ijpds-4459	6	18	underscores	underscore	VERB
ijpds-4459	6	19	the	the	DET
ijpds-4459	6	20	multidisciplinary	multidisciplinary	ADJ
ijpds-4459	6	21	collaboration	collaboration	NOUN
ijpds-4459	6	22	across	across	ADP
ijpds-4459	6	23	materials	material	NOUN
ijpds-4459	6	24	science	science	NOUN
ijpds-4459	6	25	,	,	PUNCT
ijpds-4459	6	26	immunology	immunology	NOUN
ijpds-4459	6	27	,	,	PUNCT
ijpds-4459	6	28	and	and	CCONJ
ijpds-4459	6	29	oncology	oncology	NOUN
ijpds-4459	6	30	as	as	ADP
ijpds-4459	6	31	essential	essential	ADJ
ijpds-4459	6	32	for	for	ADP
ijpds-4459	6	33	a	a	DET
ijpds-4459	6	34	holistic	holistic	ADJ
ijpds-4459	6	35	understanding	understanding	NOUN
ijpds-4459	6	36	and	and	CCONJ
ijpds-4459	6	37	effective	effective	ADJ
ijpds-4459	6	38	development	development	NOUN
ijpds-4459	6	39	of	of	ADP
ijpds-4459	6	40	biomaterial	biomaterial	NOUN
ijpds-4459	6	41	-	-	PUNCT
ijpds-4459	6	42	based	base	VERB
ijpds-4459	6	43	therapies	therapy	NOUN
ijpds-4459	6	44	.	.	PUNCT
ijpds-4459	7	1	overall	overall	ADV
ijpds-4459	7	2	,	,	PUNCT
ijpds-4459	7	3	this	this	DET
ijpds-4459	7	4	review	review	NOUN
ijpds-4459	7	5	contributes	contribute	VERB
ijpds-4459	7	6	to	to	ADP
ijpds-4459	7	7	the	the	DET
ijpds-4459	7	8	ongoing	ongoing	ADJ
ijpds-4459	7	9	shift	shift	NOUN
ijpds-4459	7	10	towards	towards	ADP
ijpds-4459	7	11	safer	safe	ADJ
ijpds-4459	7	12	,	,	PUNCT
ijpds-4459	7	13	more	more	ADV
ijpds-4459	7	14	efficacious	efficacious	ADJ
ijpds-4459	7	15	,	,	PUNCT
ijpds-4459	7	16	and	and	CCONJ
ijpds-4459	7	17	personalized	personalized	ADJ
ijpds-4459	7	18	cancer	cancer	NOUN
ijpds-4459	7	19	therapeutics	therapeutic	NOUN
ijpds-4459	7	20	by	by	ADP
ijpds-4459	7	21	exploring	explore	VERB
ijpds-4459	7	22	innovative	innovative	ADJ
ijpds-4459	7	23	avenues	avenue	NOUN
ijpds-4459	7	24	in	in	ADP
ijpds-4459	7	25	immunotherapy	immunotherapy	NOUN
ijpds-4459	7	26	and	and	CCONJ
ijpds-4459	7	27	genome	genome	NOUN
ijpds-4459	7	28	editing	editing	NOUN
ijpds-4459	7	29	,	,	PUNCT
ijpds-4459	7	30	while	while	SCONJ
ijpds-4459	7	31	emphasizing	emphasize	VERB
ijpds-4459	7	32	the	the	DET
ijpds-4459	7	33	need	need	NOUN
ijpds-4459	7	34	for	for	ADP
ijpds-4459	7	35	a	a	DET
ijpds-4459	7	36	methodologically	methodologically	ADV
ijpds-4459	7	37	rigorous	rigorous	ADJ
ijpds-4459	7	38	approach	approach	NOUN
ijpds-4459	7	39	in	in	ADP
ijpds-4459	7	40	translating	translate	VERB
ijpds-4459	7	41	these	these	DET
ijpds-4459	7	42	advancements	advancement	NOUN
ijpds-4459	7	43	to	to	ADP
ijpds-4459	7	44	clinical	clinical	ADJ
ijpds-4459	7	45	practice	practice	NOUN
ijpds-4459	7	46	.	.	PUNCT
ijpds-4459	8	1	key	key	ADJ
ijpds-4459	8	2	words	word	NOUN
ijpds-4459	8	3	:	:	PUNCT
ijpds-4459	8	4	cancer	cancer	NOUN
ijpds-4459	8	5	immunotherapy	immunotherapy	NOUN
ijpds-4459	8	6	,	,	PUNCT
ijpds-4459	8	7	precision	precision	NOUN
ijpds-4459	8	8	genome	genome	NOUN
ijpds-4459	8	9	editing	editing	NOUN
ijpds-4459	8	10	,	,	PUNCT
ijpds-4459	8	11	biomaterials	biomaterial	NOUN
ijpds-4459	8	12	,	,	PUNCT
ijpds-4459	8	13	crispr	crispr	NOUN
ijpds-4459	8	14	-	-	PUNCT
ijpds-4459	8	15	cas9	cas9	NOUN
ijpds-4459	8	16	,	,	PUNCT
ijpds-4459	8	17	combination	combination	NOUN
ijpds-4459	8	18	therapies	therapy	NOUN
ijpds-4459	8	19	.	.	PUNCT
ijpds-4459	9	1	ancer	ancer	PROPN
ijpds-4459	9	2	remains	remain	VERB
ijpds-4459	9	3	one	one	NUM
ijpds-4459	9	4	of	of	ADP
ijpds-4459	9	5	the	the	DET
ijpds-4459	9	6	most	most	ADV
ijpds-4459	9	7	formidable	formidable	ADJ
ijpds-4459	9	8	challenges	challenge	NOUN
ijpds-4459	9	9	in	in	ADP
ijpds-4459	9	10	modern	modern	ADJ
ijpds-4459	9	11	medicine	medicine	NOUN
ijpds-4459	9	12	,	,	PUNCT
ijpds-4459	9	13	affecting	affect	VERB
ijpds-4459	9	14	millions	million	NOUN
ijpds-4459	9	15	of	of	ADP
ijpds-4459	9	16	lives	life	NOUN
ijpds-4459	9	17	worldwide	worldwide	ADV
ijpds-4459	9	18	each	each	DET
ijpds-4459	9	19	year	year	NOUN
ijpds-4459	9	20	[	[	X
ijpds-4459	9	21	1	1	NUM
ijpds-4459	9	22	]	]	PUNCT
ijpds-4459	9	23	.	.	PUNCT
ijpds-4459	10	1	conventional	conventional	ADJ
ijpds-4459	10	2	therapies	therapy	NOUN
ijpds-4459	10	3	,	,	PUNCT
ijpds-4459	10	4	such	such	ADJ
ijpds-4459	10	5	as	as	ADP
ijpds-4459	10	6	chemotherapy	chemotherapy	NOUN
ijpds-4459	10	7	and	and	CCONJ
ijpds-4459	10	8	radiation	radiation	NOUN
ijpds-4459	10	9	,	,	PUNCT
ijpds-4459	10	10	have	have	AUX
ijpds-4459	10	11	made	make	VERB
ijpds-4459	10	12	significant	significant	ADJ
ijpds-4459	10	13	strides	stride	NOUN
ijpds-4459	10	14	in	in	ADP
ijpds-4459	10	15	treating	treat	VERB
ijpds-4459	10	16	certain	certain	ADJ
ijpds-4459	10	17	types	type	NOUN
ijpds-4459	10	18	of	of	ADP
ijpds-4459	10	19	cancer	cancer	NOUN
ijpds-4459	10	20	[	[	X
ijpds-4459	10	21	2	2	NUM
ijpds-4459	10	22	]	]	PUNCT
ijpds-4459	10	23	.	.	PUNCT
ijpds-4459	11	1	however	however	ADV
ijpds-4459	11	2	,	,	PUNCT
ijpds-4459	11	3	their	their	PRON
ijpds-4459	11	4	limitations	limitation	NOUN
ijpds-4459	11	5	,	,	PUNCT
ijpds-4459	11	6	such	such	ADJ
ijpds-4459	11	7	as	as	ADP
ijpds-4459	11	8	off	off	ADP
ijpds-4459	11	9	-	-	PUNCT
ijpds-4459	11	10	target	target	NOUN
ijpds-4459	11	11	effects	effect	NOUN
ijpds-4459	11	12	and	and	CCONJ
ijpds-4459	11	13	drug	drug	NOUN
ijpds-4459	11	14	resistance	resistance	NOUN
ijpds-4459	11	15	,	,	PUNCT
ijpds-4459	11	16	have	have	AUX
ijpds-4459	11	17	underscored	underscore	VERB
ijpds-4459	11	18	the	the	DET
ijpds-4459	11	19	need	need	NOUN
ijpds-4459	11	20	for	for	ADP
ijpds-4459	11	21	novel	novel	ADJ
ijpds-4459	11	22	therapeutic	therapeutic	ADJ
ijpds-4459	11	23	approaches	approach	NOUN
ijpds-4459	11	24	[	[	X
ijpds-4459	11	25	3	3	NUM
ijpds-4459	11	26	]	]	PUNCT
ijpds-4459	11	27	.	.	PUNCT
ijpds-4459	12	1	in	in	ADP
ijpds-4459	12	2	recent	recent	ADJ
ijpds-4459	12	3	years	year	NOUN
ijpds-4459	12	4	,	,	PUNCT
ijpds-4459	12	5	cancer	cancer	NOUN
ijpds-4459	12	6	immunotherapy	immunotherapy	NOUN
ijpds-4459	12	7	[	[	X
ijpds-4459	12	8	4	4	X
ijpds-4459	12	9	]	]	PUNCT
ijpds-4459	12	10	and	and	CCONJ
ijpds-4459	12	11	precision	precision	NOUN
ijpds-4459	12	12	genome	genome	NOUN
ijpds-4459	12	13	editing	editing	NOUN
ijpds-4459	12	14	[	[	X
ijpds-4459	12	15	5	5	NUM
ijpds-4459	12	16	]	]	PUNCT
ijpds-4459	12	17	have	have	AUX
ijpds-4459	12	18	emerged	emerge	VERB
ijpds-4459	12	19	as	as	ADP
ijpds-4459	12	20	promising	promise	VERB
ijpds-4459	12	21	fields	field	NOUN
ijpds-4459	12	22	that	that	PRON
ijpds-4459	12	23	hold	hold	VERB
ijpds-4459	12	24	the	the	DET
ijpds-4459	12	25	potential	potential	NOUN
ijpds-4459	12	26	to	to	PART
ijpds-4459	12	27	revolutionize	revolutionize	VERB
ijpds-4459	12	28	cancer	cancer	NOUN
ijpds-4459	12	29	treatment	treatment	NOUN
ijpds-4459	12	30	.	.	PUNCT
ijpds-4459	13	1	the	the	DET
ijpds-4459	13	2	landscape	landscape	NOUN
ijpds-4459	13	3	of	of	ADP
ijpds-4459	13	4	oncology	oncology	NOUN
ijpds-4459	13	5	has	have	AUX
ijpds-4459	13	6	undergone	undergo	VERB
ijpds-4459	13	7	a	a	DET
ijpds-4459	13	8	transformative	transformative	ADJ
ijpds-4459	13	9	shift	shift	NOUN
ijpds-4459	13	10	with	with	ADP
ijpds-4459	13	11	the	the	DET
ijpds-4459	13	12	integration	integration	NOUN
ijpds-4459	13	13	of	of	ADP
ijpds-4459	13	14	immune	immune	ADJ
ijpds-4459	13	15	system	system	NOUN
ijpds-4459	13	16	harnessing	harnessing	NOUN
ijpds-4459	13	17	and	and	CCONJ
ijpds-4459	13	18	genome	genome	NOUN
ijpds-4459	13	19	editing	editing	NOUN
ijpds-4459	13	20	technologies	technology	NOUN
ijpds-4459	13	21	,	,	PUNCT
ijpds-4459	13	22	notably	notably	ADV
ijpds-4459	13	23	the	the	DET
ijpds-4459	13	24	revolutionary	revolutionary	ADJ
ijpds-4459	13	25	crispr	crispr	ADJ
ijpds-4459	13	26	-	-	PUNCT
ijpds-4459	13	27	cas9	cas9	NOUN
ijpds-4459	13	28	system	system	NOUN
ijpds-4459	13	29	[	[	X
ijpds-4459	13	30	6	6	NUM
ijpds-4459	13	31	]	]	PUNCT
ijpds-4459	13	32	.	.	PUNCT
ijpds-4459	14	1	three	three	NUM
ijpds-4459	14	2	primary	primary	ADJ
ijpds-4459	14	3	facets	facet	NOUN
ijpds-4459	14	4	define	define	VERB
ijpds-4459	14	5	this	this	DET
ijpds-4459	14	6	paradigm	paradigm	NOUN
ijpds-4459	14	7	shift	shift	NOUN
ijpds-4459	14	8	in	in	ADP
ijpds-4459	14	9	cancer	cancer	NOUN
ijpds-4459	14	10	treatment	treatment	NOUN
ijpds-4459	14	11	.	.	PUNCT
ijpds-4459	15	1	immune	immune	ADJ
ijpds-4459	15	2	checkpoint	checkpoint	NOUN
ijpds-4459	15	3	inhibitors	inhibitor	NOUN
ijpds-4459	15	4	,	,	PUNCT
ijpds-4459	15	5	such	such	ADJ
ijpds-4459	15	6	as	as	ADP
ijpds-4459	15	7	nivolumab	nivolumab	NOUN
ijpds-4459	15	8	,	,	PUNCT
ijpds-4459	15	9	access	access	NOUN
ijpds-4459	15	10	this	this	DET
ijpds-4459	15	11	article	article	NOUN
ijpds-4459	15	12	online	online	ADV
ijpds-4459	15	13	received	receive	VERB
ijpds-4459	15	14	–	–	PUNCT
ijpds-4459	15	15	31st	31st	NOUN
ijpds-4459	15	16	jan	jan	PROPN
ijpds-4459	15	17	2024	2024	NUM
ijpds-4459	15	18	initial	initial	ADJ
ijpds-4459	15	19	review	review	NOUN
ijpds-4459	15	20	–	–	PUNCT
ijpds-4459	15	21	27th	27th	ADJ
ijpds-4459	15	22	feb	feb	X
ijpds-4459	15	23	2024	2024	NUM
ijpds-4459	15	24	accepted	accept	VERB
ijpds-4459	15	25	–	–	PUNCT
ijpds-4459	15	26	15th	15th	ADJ
ijpds-4459	15	27	feb	feb	NOUN
ijpds-4459	15	28	2024	2024	NUM
ijpds-4459	15	29	quick	quick	ADJ
ijpds-4459	15	30	response	response	NOUN
ijpds-4459	15	31	code	code	NOUN
ijpds-4459	15	32	pembrolizumab	pembrolizumab	NOUN
ijpds-4459	15	33	,	,	PUNCT
ijpds-4459	15	34	atezolizumab	atezolizumab	NOUN
ijpds-4459	15	35	,	,	PUNCT
ijpds-4459	15	36	durvalumab	durvalumab	NOUN
ijpds-4459	15	37	(	(	PUNCT
ijpds-4459	15	38	imfinzi	imfinzi	PROPN
ijpds-4459	15	39	)	)	PUNCT
ijpds-4459	15	40	,	,	PUNCT
ijpds-4459	15	41	ipilimumab	ipilimumab	NOUN
ijpds-4459	15	42	(	(	PUNCT
ijpds-4459	15	43	yervoy	yervoy	NOUN
ijpds-4459	15	44	)	)	PUNCT
ijpds-4459	15	45	,	,	PUNCT
ijpds-4459	15	46	and	and	CCONJ
ijpds-4459	15	47	cemiplimab	cemiplimab	NOUN
ijpds-4459	15	48	(	(	PUNCT
ijpds-4459	15	49	libtayo	libtayo	PROPN
ijpds-4459	15	50	)	)	PUNCT
ijpds-4459	15	51	,	,	PUNCT
ijpds-4459	15	52	have	have	AUX
ijpds-4459	15	53	demonstrated	demonstrate	VERB
ijpds-4459	15	54	success	success	NOUN
ijpds-4459	15	55	in	in	ADP
ijpds-4459	15	56	treating	treat	VERB
ijpds-4459	15	57	various	various	ADJ
ijpds-4459	15	58	cancers	cancer	NOUN
ijpds-4459	15	59	,	,	PUNCT
ijpds-4459	15	60	including	include	VERB
ijpds-4459	15	61	bladder	bladder	NOUN
ijpds-4459	15	62	cancer	cancer	NOUN
ijpds-4459	15	63	,	,	PUNCT
ijpds-4459	15	64	non	non	ADJ
ijpds-4459	15	65	-	-	ADJ
ijpds-4459	15	66	small	small	ADJ
ijpds-4459	15	67	cell	cell	NOUN
ijpds-4459	15	68	lung	lung	NOUN
ijpds-4459	15	69	cancer	cancer	NOUN
ijpds-4459	15	70	,	,	PUNCT
ijpds-4459	15	71	head	head	NOUN
ijpds-4459	15	72	and	and	CCONJ
ijpds-4459	15	73	neck	neck	VERB
ijpds-4459	15	74	squamous	squamous	ADJ
ijpds-4459	15	75	cell	cell	NOUN
ijpds-4459	15	76	carcinoma	carcinoma	NOUN
ijpds-4459	15	77	,	,	PUNCT
ijpds-4459	15	78	melanoma	melanoma	NOUN
ijpds-4459	15	79	,	,	PUNCT
ijpds-4459	15	80	renal	renal	ADJ
ijpds-4459	15	81	cell	cell	NOUN
ijpds-4459	15	82	carcinoma	carcinoma	NOUN
ijpds-4459	15	83	,	,	PUNCT
ijpds-4459	15	84	and	and	CCONJ
ijpds-4459	15	85	advanced	advanced	ADJ
ijpds-4459	15	86	cervical	cervical	ADJ
ijpds-4459	15	87	cancer	cancer	NOUN
ijpds-4459	15	88	,	,	PUNCT
ijpds-4459	15	89	enhancing	enhance	VERB
ijpds-4459	15	90	overall	overall	ADJ
ijpds-4459	15	91	survival	survival	NOUN
ijpds-4459	15	92	rates	rate	NOUN
ijpds-4459	15	93	and	and	CCONJ
ijpds-4459	15	94	response	response	NOUN
ijpds-4459	15	95	durability	durability	NOUN
ijpds-4459	15	96	[	[	X
ijpds-4459	15	97	7	7	NUM
ijpds-4459	15	98	]	]	PUNCT
ijpds-4459	15	99	.	.	PUNCT
ijpds-4459	16	1	adoptive	adoptive	PROPN
ijpds-4459	16	2	t	t	PROPN
ijpds-4459	16	3	cell	cell	NOUN
ijpds-4459	16	4	therapies	therapy	NOUN
ijpds-4459	16	5	,	,	PUNCT
ijpds-4459	16	6	exemplified	exemplify	VERB
ijpds-4459	16	7	by	by	ADP
ijpds-4459	16	8	chimeric	chimeric	ADJ
ijpds-4459	16	9	antigen	antigen	ADJ
ijpds-4459	16	10	receptor	receptor	NOUN
ijpds-4459	16	11	(	(	PUNCT
ijpds-4459	16	12	car	car	NOUN
ijpds-4459	16	13	)	)	PUNCT
ijpds-4459	16	14	t	t	NOUN
ijpds-4459	16	15	-	-	PUNCT
ijpds-4459	16	16	cell	cell	NOUN
ijpds-4459	16	17	therapy	therapy	NOUN
ijpds-4459	16	18	,	,	PUNCT
ijpds-4459	16	19	represent	represent	VERB
ijpds-4459	16	20	a	a	DET
ijpds-4459	16	21	groundbreaking	groundbreake	VERB
ijpds-4459	16	22	approach	approach	NOUN
ijpds-4459	16	23	.	.	PUNCT
ijpds-4459	17	1	examples	example	NOUN
ijpds-4459	17	2	such	such	ADJ
ijpds-4459	17	3	as	as	ADP
ijpds-4459	17	4	daliyno	daliyno	ADJ
ijpds-4459	17	5	(	(	PUNCT
ijpds-4459	17	6	tilmesogenecel	tilmesogenecel	NOUN
ijpds-4459	17	7	)	)	PUNCT
ijpds-4459	17	8	,	,	PUNCT
ijpds-4459	17	9	breyanzi	breyanzi	X
ijpds-4459	17	10	(	(	PUNCT
ijpds-4459	17	11	lisocabtagenedarolumab	lisocabtagenedarolumab	NOUN
ijpds-4459	17	12	)	)	PUNCT
ijpds-4459	17	13	,	,	PUNCT
ijpds-4459	17	14	and	and	CCONJ
ijpds-4459	17	15	tecartus	tecartus	NOUN
ijpds-4459	17	16	(	(	PUNCT
ijpds-4459	17	17	breceltinib	breceltinib	NOUN
ijpds-4459	17	18	)	)	PUNCT
ijpds-4459	17	19	utilize	utilize	VERB
ijpds-4459	17	20	a	a	DET
ijpds-4459	17	21	patient	patient	NOUN
ijpds-4459	17	22	's	's	PART
ijpds-4459	17	23	own	own	ADJ
ijpds-4459	17	24	tumor	tumor	NOUN
ijpds-4459	17	25	-	-	PUNCT
ijpds-4459	17	26	infiltrating	infiltrate	VERB
ijpds-4459	17	27	lymphocytes	lymphocyte	NOUN
ijpds-4459	17	28	(	(	PUNCT
ijpds-4459	17	29	tils	til	NOUN
ijpds-4459	17	30	)	)	PUNCT
ijpds-4459	17	31	or	or	CCONJ
ijpds-4459	17	32	engineered	engineer	VERB
ijpds-4459	17	33	car	car	NOUN
ijpds-4459	17	34	t	t	NOUN
ijpds-4459	17	35	-	-	PUNCT
ijpds-4459	17	36	cells	cell	NOUN
ijpds-4459	17	37	to	to	PART
ijpds-4459	17	38	precisely	precisely	ADV
ijpds-4459	17	39	target	target	VERB
ijpds-4459	17	40	melanoma	melanoma	NOUN
ijpds-4459	17	41	,	,	PUNCT
ijpds-4459	17	42	large	large	ADJ
ijpds-4459	17	43	b	b	NOUN
ijpds-4459	17	44	-	-	PUNCT
ijpds-4459	17	45	cell	cell	NOUN
ijpds-4459	17	46	lymphoma	lymphoma	NOUN
ijpds-4459	17	47	,	,	PUNCT
ijpds-4459	17	48	and	and	CCONJ
ijpds-4459	17	49	mantle	mantle	NOUN
ijpds-4459	17	50	cell	cell	NOUN
ijpds-4459	17	51	lymphoma	lymphoma	NOUN
ijpds-4459	18	1	[	[	X
ijpds-4459	18	2	8].cancer	8].cancer	NUM
ijpds-4459	18	3	vaccines	vaccine	NOUN
ijpds-4459	18	4	,	,	PUNCT
ijpds-4459	18	5	including	include	VERB
ijpds-4459	18	6	gvax	gvax	PROPN
ijpds-4459	18	7	(	(	PUNCT
ijpds-4459	18	8	rasilmuplasmid	rasilmuplasmid	PROPN
ijpds-4459	18	9	)	)	PUNCT
ijpds-4459	18	10	,	,	PUNCT
ijpds-4459	18	11	papillomavirus	papillomavirus	NOUN
ijpds-4459	18	12	vaccines	vaccine	NOUN
ijpds-4459	18	13	(	(	PUNCT
ijpds-4459	18	14	gardasil	gardasil	NOUN
ijpds-4459	18	15	,	,	PUNCT
ijpds-4459	18	16	cervarix	cervarix	NOUN
ijpds-4459	18	17	)	)	PUNCT
ijpds-4459	18	18	,	,	PUNCT
ijpds-4459	18	19	and	and	CCONJ
ijpds-4459	18	20	personalized	personalize	VERB
ijpds-4459	18	21	neoantigen	neoantigen	NOUN
ijpds-4459	18	22	vaccines	vaccine	NOUN
ijpds-4459	18	23	,	,	PUNCT
ijpds-4459	18	24	stimulate	stimulate	VERB
ijpds-4459	18	25	the	the	DET
ijpds-4459	18	26	immune	immune	ADJ
ijpds-4459	18	27	system	system	NOUN
ijpds-4459	18	28	to	to	PART
ijpds-4459	18	29	identify	identify	VERB
ijpds-4459	18	30	and	and	CCONJ
ijpds-4459	18	31	eliminate	eliminate	VERB
ijpds-4459	18	32	cancer	cancer	NOUN
ijpds-4459	18	33	cells	cell	NOUN
ijpds-4459	18	34	,	,	PUNCT
ijpds-4459	18	35	showcasing	showcase	VERB
ijpds-4459	18	36	a	a	DET
ijpds-4459	18	37	personalized	personalized	ADJ
ijpds-4459	18	38	treatment	treatment	NOUN
ijpds-4459	18	39	approach	approach	NOUN
ijpds-4459	18	40	[	[	X
ijpds-4459	18	41	9	9	NUM
ijpds-4459	18	42	]	]	PUNCT
ijpds-4459	18	43	.	.	PUNCT
ijpds-4459	19	1	_	_	PUNCT
ijpds-4459	20	1	_	_	PUNCT
ijpds-4459	21	1	_	_	PUNCT
ijpds-4459	22	1	_	_	PUNCT
ijpds-4459	23	1	_	_	PUNCT
ijpds-4459	24	1	_	_	PUNCT
ijpds-4459	25	1	_	_	PUNCT
ijpds-4459	26	1	_	_	PUNCT
ijpds-4459	27	1	_	_	PUNCT
ijpds-4459	28	1	_	_	PUNCT
ijpds-4459	29	1	_	_	PUNCT
ijpds-4459	30	1	_	_	PUNCT
ijpds-4459	31	1	_	_	PUNCT
ijpds-4459	32	1	_	_	PUNCT
ijpds-4459	33	1	_	_	PUNCT
ijpds-4459	34	1	_	_	PUNCT
ijpds-4459	35	1	_	_	PUNCT
ijpds-4459	36	1	_	_	PUNCT
ijpds-4459	37	1	_	_	PUNCT
ijpds-4459	38	1	_	_	PUNCT
ijpds-4459	39	1	_	_	PUNCT
ijpds-4459	40	1	_	_	PUNCT
ijpds-4459	41	1	_	_	PUNCT
ijpds-4459	42	1	_	_	PUNCT
ijpds-4459	43	1	_	_	PUNCT
ijpds-4459	44	1	_	_	PUNCT
ijpds-4459	45	1	_	_	PUNCT
ijpds-4459	46	1	_	_	PUNCT
ijpds-4459	47	1	_	_	PUNCT
ijpds-4459	48	1	_	_	PUNCT
ijpds-4459	49	1	_	_	PUNCT
ijpds-4459	50	1	_	_	PUNCT
ijpds-4459	51	1	_	_	PUNCT
ijpds-4459	52	1	_	_	PUNCT
ijpds-4459	53	1	_	_	PUNCT
ijpds-4459	54	1	_	_	PUNCT
ijpds-4459	55	1	_	_	PUNCT
ijpds-4459	56	1	_	_	PUNCT
ijpds-4459	57	1	_	_	PUNCT
ijpds-4459	58	1	_	_	PUNCT
ijpds-4459	59	1	_	_	PUNCT
ijpds-4459	60	1	_	_	PUNCT
ijpds-4459	61	1	_	_	PUNCT
ijpds-4459	62	1	_	_	PUNCT
ijpds-4459	63	1	_	_	PUNCT
ijpds-4459	64	1	_	_	PUNCT
ijpds-4459	65	1	_	_	PUNCT
ijpds-4459	66	1	_	_	PUNCT
ijpds-4459	67	1	_	_	PUNCT
ijpds-4459	68	1	_	_	PUNCT
ijpds-4459	68	2	correspondence	correspondence	NOUN
ijpds-4459	68	3	to	to	ADP
ijpds-4459	68	4	:	:	PUNCT
ijpds-4459	68	5	ramdas	ramdas	PROPN
ijpds-4459	68	6	bhat	bhat	PROPN
ijpds-4459	68	7	,	,	PUNCT
ijpds-4459	68	8	associate	associate	NOUN
ijpds-4459	68	9	professor	professor	NOUN
ijpds-4459	68	10	,	,	PUNCT
ijpds-4459	68	11	dept	dept	NOUN
ijpds-4459	68	12	.	.	PROPN
ijpds-4459	68	13	of	of	ADP
ijpds-4459	68	14	pharmacology	pharmacology	NOUN
ijpds-4459	68	15	,	,	PUNCT
ijpds-4459	68	16	srinivas	srinivas	PROPN
ijpds-4459	68	17	college	college	PROPN
ijpds-4459	68	18	of	of	ADP
ijpds-4459	68	19	pharmacy	pharmacy	NOUN
ijpds-4459	68	20	,	,	PUNCT
ijpds-4459	68	21	valachil	valachil	NOUN
ijpds-4459	68	22	,	,	PUNCT
ijpds-4459	68	23	post	post	NOUN
ijpds-4459	68	24	farangipete	farangipete	NOUN
ijpds-4459	68	25	,	,	PUNCT
ijpds-4459	68	26	mangalore	mangalore	PROPN
ijpds-4459	68	27	,	,	PUNCT
ijpds-4459	68	28	karnataka	karnataka	ADJ
ijpds-4459	68	29	,	,	PUNCT
ijpds-4459	68	30	india-574143	india-574143	NOUN
ijpds-4459	68	31	.	.	PUNCT
ijpds-4459	69	1	email	email	NOUN
ijpds-4459	69	2	:	:	PUNCT
ijpds-4459	69	3	ramdas21@gmail.com	ramdas21@gmail.com	PROPN
ijpds-4459	69	4	,	,	PUNCT
ijpds-4459	69	5	tel	tel	PROPN
ijpds-4459	69	6	.	.	PUNCT
ijpds-4459	69	7	:	:	PUNCT
ijpds-4459	70	1	+91	+91	PROPN
ijpds-4459	70	2	7795772463	7795772463	NUM
ijpds-4459	70	3	.	.	PUNCT
ijpds-4459	71	1	c	c	PROPN
ijpds-4459	71	2	mailto:ramdas21@gmail.com	mailto:ramdas21@gmail.com	PROPN
ijpds-4459	71	3	bhat	bhat	PROPN
ijpds-4459	71	4	&	&	CCONJ
ijpds-4459	71	5	shanbhag	shanbhag	NOUN
ijpds-4459	71	6	biomaterials	biomaterial	NOUN
ijpds-4459	71	7	:	:	PUNCT
ijpds-4459	71	8	revolutionizing	revolutionize	VERB
ijpds-4459	71	9	cancer	cancer	NOUN
ijpds-4459	71	10	immunotherapy	immunotherapy	NOUN
ijpds-4459	71	11	and	and	CCONJ
ijpds-4459	71	12	genomics	genomics	NOUN
ijpds-4459	71	13	vol	vol	NOUN
ijpds-4459	71	14	3	3	NUM
ijpds-4459	71	15	|	|	NOUN
ijpds-4459	71	16	issue	issue	NOUN
ijpds-4459	71	17	2	2	NUM
ijpds-4459	71	18	|	|	ADV
ijpds-4459	71	19	apr	apr	NOUN
ijpds-4459	71	20	–	–	PUNCT
ijpds-4459	71	21	jun	jun	PROPN
ijpds-4459	71	22	2024	2024	NUM
ijpds-4459	71	23	indian	indian	PROPN
ijpds-4459	71	24	j	j	PROPN
ijpds-4459	71	25	pharm	pharm	PROPN
ijpds-4459	71	26	drug	drug	PROPN
ijpds-4459	71	27	studies	study	NOUN
ijpds-4459	71	28	|	|	ADV
ijpds-4459	71	29	38	38	NUM
ijpds-4459	71	30	in	in	ADP
ijpds-4459	71	31	the	the	DET
ijpds-4459	71	32	realm	realm	NOUN
ijpds-4459	71	33	of	of	ADP
ijpds-4459	71	34	genome	genome	NOUN
ijpds-4459	71	35	editing	editing	NOUN
ijpds-4459	71	36	,	,	PUNCT
ijpds-4459	71	37	the	the	DET
ijpds-4459	71	38	crispr	crispr	NOUN
ijpds-4459	71	39	/	/	SYM
ijpds-4459	71	40	cas-9	cas-9	PUNCT
ijpds-4459	71	41	system	system	NOUN
ijpds-4459	71	42	stands	stand	VERB
ijpds-4459	71	43	out	out	ADP
ijpds-4459	71	44	as	as	ADP
ijpds-4459	71	45	a	a	DET
ijpds-4459	71	46	powerful	powerful	ADJ
ijpds-4459	71	47	tool	tool	NOUN
ijpds-4459	71	48	,	,	PUNCT
ijpds-4459	71	49	exhibiting	exhibit	VERB
ijpds-4459	71	50	promise	promise	NOUN
ijpds-4459	71	51	in	in	ADP
ijpds-4459	71	52	correcting	correct	VERB
ijpds-4459	71	53	mutations	mutation	NOUN
ijpds-4459	71	54	and	and	CCONJ
ijpds-4459	71	55	restraining	restrain	VERB
ijpds-4459	71	56	tumor	tumor	NOUN
ijpds-4459	71	57	growth	growth	NOUN
ijpds-4459	71	58	in	in	ADP
ijpds-4459	71	59	cancer	cancer	NOUN
ijpds-4459	71	60	research	research	NOUN
ijpds-4459	71	61	and	and	CCONJ
ijpds-4459	71	62	treatment	treatment	NOUN
ijpds-4459	71	63	.	.	PUNCT
ijpds-4459	72	1	additionally	additionally	ADV
ijpds-4459	72	2	,	,	PUNCT
ijpds-4459	72	3	zinc	zinc	NOUN
ijpds-4459	72	4	finger	finger	NOUN
ijpds-4459	72	5	nucleases	nuclease	NOUN
ijpds-4459	72	6	(	(	PUNCT
ijpds-4459	72	7	zfns	zfns	NOUN
ijpds-4459	72	8	)	)	PUNCT
ijpds-4459	72	9	,	,	PUNCT
ijpds-4459	72	10	transcription	transcription	NOUN
ijpds-4459	72	11	activator	activator	NOUN
ijpds-4459	72	12	-	-	PUNCT
ijpds-4459	72	13	like	like	ADJ
ijpds-4459	72	14	effector	effector	NOUN
ijpds-4459	72	15	nucleases	nuclease	NOUN
ijpds-4459	72	16	(	(	PUNCT
ijpds-4459	72	17	talens	talen	NOUN
ijpds-4459	72	18	)	)	PUNCT
ijpds-4459	72	19	,	,	PUNCT
ijpds-4459	72	20	base	base	NOUN
ijpds-4459	72	21	editing	editing	NOUN
ijpds-4459	72	22	,	,	PUNCT
ijpds-4459	72	23	and	and	CCONJ
ijpds-4459	72	24	hdr	hdr	NOUN
ijpds-4459	72	25	(	(	PUNCT
ijpds-4459	72	26	homology	homology	NOUN
ijpds-4459	72	27	-	-	PUNCT
ijpds-4459	72	28	directed	direct	VERB
ijpds-4459	72	29	repair	repair	NOUN
ijpds-4459	72	30	)	)	PUNCT
ijpds-4459	72	31	join	join	VERB
ijpds-4459	72	32	the	the	DET
ijpds-4459	72	33	ranks	rank	NOUN
ijpds-4459	72	34	of	of	ADP
ijpds-4459	72	35	precision	precision	NOUN
ijpds-4459	72	36	genome	genome	NOUN
ijpds-4459	72	37	editing	editing	NOUN
ijpds-4459	72	38	technologies	technology	NOUN
ijpds-4459	72	39	,	,	PUNCT
ijpds-4459	72	40	expanding	expand	VERB
ijpds-4459	72	41	the	the	DET
ijpds-4459	72	42	toolkit	toolkit	NOUN
ijpds-4459	72	43	with	with	ADP
ijpds-4459	72	44	their	their	PRON
ijpds-4459	72	45	unique	unique	ADJ
ijpds-4459	72	46	capabilities	capability	NOUN
ijpds-4459	72	47	[	[	X
ijpds-4459	72	48	10	10	NUM
ijpds-4459	72	49	-	-	SYM
ijpds-4459	72	50	13	13	NUM
ijpds-4459	72	51	]	]	PUNCT
ijpds-4459	72	52	.	.	PUNCT
ijpds-4459	73	1	these	these	DET
ijpds-4459	73	2	advancements	advancement	NOUN
ijpds-4459	73	3	collectively	collectively	ADV
ijpds-4459	73	4	hold	hold	VERB
ijpds-4459	73	5	immense	immense	ADJ
ijpds-4459	73	6	potential	potential	NOUN
ijpds-4459	73	7	in	in	ADP
ijpds-4459	73	8	advancing	advance	VERB
ijpds-4459	73	9	cancer	cancer	NOUN
ijpds-4459	73	10	therapies	therapy	NOUN
ijpds-4459	73	11	,	,	PUNCT
ijpds-4459	73	12	ushering	usher	VERB
ijpds-4459	73	13	in	in	ADP
ijpds-4459	73	14	a	a	DET
ijpds-4459	73	15	new	new	ADJ
ijpds-4459	73	16	era	era	NOUN
ijpds-4459	73	17	of	of	ADP
ijpds-4459	73	18	personalized	personalized	ADJ
ijpds-4459	73	19	and	and	CCONJ
ijpds-4459	73	20	targeted	target	VERB
ijpds-4459	73	21	interventions	intervention	NOUN
ijpds-4459	73	22	for	for	ADP
ijpds-4459	73	23	improved	improved	ADJ
ijpds-4459	73	24	patient	patient	NOUN
ijpds-4459	73	25	outcomes.in	outcomes.in	NUM
ijpds-4459	73	26	cancer	cancer	NOUN
ijpds-4459	73	27	,	,	PUNCT
ijpds-4459	73	28	the	the	DET
ijpds-4459	73	29	potential	potential	NOUN
ijpds-4459	73	30	to	to	PART
ijpds-4459	73	31	target	target	VERB
ijpds-4459	73	32	and	and	CCONJ
ijpds-4459	73	33	correct	correct	VERB
ijpds-4459	73	34	genetic	genetic	ADJ
ijpds-4459	73	35	mutations	mutation	NOUN
ijpds-4459	73	36	implicated	implicate	VERB
ijpds-4459	73	37	in	in	ADP
ijpds-4459	73	38	tumor	tumor	NOUN
ijpds-4459	73	39	development	development	NOUN
ijpds-4459	73	40	offers	offer	VERB
ijpds-4459	73	41	unprecedented	unprecedented	ADJ
ijpds-4459	73	42	opportunities	opportunity	NOUN
ijpds-4459	73	43	for	for	ADP
ijpds-4459	73	44	precision	precision	NOUN
ijpds-4459	73	45	medicine	medicine	NOUN
ijpds-4459	73	46	[	[	X
ijpds-4459	73	47	14	14	NUM
ijpds-4459	73	48	]	]	PUNCT
ijpds-4459	73	49	.	.	PUNCT
ijpds-4459	74	1	however	however	ADV
ijpds-4459	74	2	,	,	PUNCT
ijpds-4459	74	3	successful	successful	ADJ
ijpds-4459	74	4	cancer	cancer	NOUN
ijpds-4459	74	5	immunotherapy	immunotherapy	NOUN
ijpds-4459	74	6	and	and	CCONJ
ijpds-4459	74	7	genome	genome	NOUN
ijpds-4459	74	8	editing	editing	NOUN
ijpds-4459	74	9	demand	demand	NOUN
ijpds-4459	74	10	efficient	efficient	ADJ
ijpds-4459	74	11	and	and	CCONJ
ijpds-4459	74	12	controlled	control	VERB
ijpds-4459	74	13	delivery	delivery	NOUN
ijpds-4459	74	14	systems	system	NOUN
ijpds-4459	74	15	to	to	PART
ijpds-4459	74	16	ensure	ensure	VERB
ijpds-4459	74	17	therapeutic	therapeutic	ADJ
ijpds-4459	74	18	agents	agent	NOUN
ijpds-4459	74	19	reach	reach	VERB
ijpds-4459	74	20	their	their	PRON
ijpds-4459	74	21	targets	target	NOUN
ijpds-4459	74	22	with	with	ADP
ijpds-4459	74	23	minimal	minimal	ADJ
ijpds-4459	74	24	side	side	NOUN
ijpds-4459	74	25	effects	effect	NOUN
ijpds-4459	74	26	[	[	X
ijpds-4459	74	27	15	15	NUM
ijpds-4459	74	28	]	]	PUNCT
ijpds-4459	74	29	.	.	PUNCT
ijpds-4459	75	1	this	this	PRON
ijpds-4459	75	2	is	be	AUX
ijpds-4459	75	3	where	where	SCONJ
ijpds-4459	75	4	cutting	cutting	NOUN
ijpds-4459	75	5	-	-	PUNCT
ijpds-4459	75	6	edge	edge	NOUN
ijpds-4459	75	7	biomaterials	biomaterial	NOUN
ijpds-4459	75	8	play	play	VERB
ijpds-4459	75	9	a	a	DET
ijpds-4459	75	10	pivotal	pivotal	ADJ
ijpds-4459	75	11	role	role	NOUN
ijpds-4459	75	12	[	[	X
ijpds-4459	75	13	16	16	NUM
ijpds-4459	75	14	]	]	PUNCT
ijpds-4459	75	15	.	.	PUNCT
ijpds-4459	76	1	biomaterials	biomaterial	NOUN
ijpds-4459	76	2	have	have	AUX
ijpds-4459	76	3	emerged	emerge	VERB
ijpds-4459	76	4	as	as	ADP
ijpds-4459	76	5	essential	essential	ADJ
ijpds-4459	76	6	tools	tool	NOUN
ijpds-4459	76	7	to	to	PART
ijpds-4459	76	8	optimize	optimize	VERB
ijpds-4459	76	9	cancer	cancer	NOUN
ijpds-4459	76	10	immunotherapy	immunotherapy	NOUN
ijpds-4459	76	11	and	and	CCONJ
ijpds-4459	76	12	genome	genome	NOUN
ijpds-4459	76	13	editing	editing	NOUN
ijpds-4459	76	14	by	by	ADP
ijpds-4459	76	15	providing	provide	VERB
ijpds-4459	76	16	tailored	tailored	ADJ
ijpds-4459	76	17	platforms	platform	NOUN
ijpds-4459	76	18	for	for	ADP
ijpds-4459	76	19	drug	drug	NOUN
ijpds-4459	76	20	delivery	delivery	NOUN
ijpds-4459	76	21	,	,	PUNCT
ijpds-4459	76	22	enhancing	enhance	VERB
ijpds-4459	76	23	immune	immune	ADJ
ijpds-4459	76	24	response	response	NOUN
ijpds-4459	76	25	,	,	PUNCT
ijpds-4459	76	26	and	and	CCONJ
ijpds-4459	76	27	improving	improve	VERB
ijpds-4459	76	28	gene	gene	NOUN
ijpds-4459	76	29	editing	edit	VERB
ijpds-4459	76	30	efficiency	efficiency	NOUN
ijpds-4459	76	31	[	[	X
ijpds-4459	76	32	17	17	NUM
ijpds-4459	76	33	]	]	PUNCT
ijpds-4459	76	34	.	.	PUNCT
ijpds-4459	77	1	in	in	ADP
ijpds-4459	77	2	this	this	DET
ijpds-4459	77	3	review	review	NOUN
ijpds-4459	77	4	article	article	NOUN
ijpds-4459	77	5	,	,	PUNCT
ijpds-4459	77	6	we	we	PRON
ijpds-4459	77	7	explore	explore	VERB
ijpds-4459	77	8	the	the	DET
ijpds-4459	77	9	latest	late	ADJ
ijpds-4459	77	10	advancements	advancement	NOUN
ijpds-4459	77	11	in	in	ADP
ijpds-4459	77	12	harnessing	harness	VERB
ijpds-4459	77	13	the	the	DET
ijpds-4459	77	14	power	power	NOUN
ijpds-4459	77	15	of	of	ADP
ijpds-4459	77	16	biomaterials	biomaterial	NOUN
ijpds-4459	77	17	for	for	ADP
ijpds-4459	77	18	cancer	cancer	NOUN
ijpds-4459	77	19	immunotherapy	immunotherapy	NOUN
ijpds-4459	77	20	and	and	CCONJ
ijpds-4459	77	21	precision	precision	NOUN
ijpds-4459	77	22	genome	genome	NOUN
ijpds-4459	77	23	editing	editing	NOUN
ijpds-4459	77	24	[	[	X
ijpds-4459	77	25	18	18	NUM
ijpds-4459	77	26	]	]	PUNCT
ijpds-4459	77	27	.	.	PUNCT
ijpds-4459	78	1	we	we	PRON
ijpds-4459	78	2	delve	delve	VERB
ijpds-4459	78	3	into	into	ADP
ijpds-4459	78	4	various	various	ADJ
ijpds-4459	78	5	types	type	NOUN
ijpds-4459	78	6	of	of	ADP
ijpds-4459	78	7	biomaterials	biomaterial	NOUN
ijpds-4459	78	8	,	,	PUNCT
ijpds-4459	78	9	including	include	VERB
ijpds-4459	78	10	nanoparticles	nanoparticle	NOUN
ijpds-4459	78	11	[	[	X
ijpds-4459	78	12	19	19	NUM
ijpds-4459	78	13	]	]	PUNCT
ijpds-4459	78	14	,	,	PUNCT
ijpds-4459	78	15	hydrogels	hydrogel	NOUN
ijpds-4459	78	16	[	[	X
ijpds-4459	78	17	20	20	NUM
ijpds-4459	78	18	]	]	PUNCT
ijpds-4459	78	19	,	,	PUNCT
ijpds-4459	78	20	and	and	CCONJ
ijpds-4459	78	21	viral	viral	ADJ
ijpds-4459	78	22	vectors	vector	NOUN
ijpds-4459	78	23	[	[	X
ijpds-4459	78	24	21	21	NUM
ijpds-4459	78	25	]	]	PUNCT
ijpds-4459	78	26	,	,	PUNCT
ijpds-4459	78	27	and	and	CCONJ
ijpds-4459	78	28	their	their	PRON
ijpds-4459	78	29	applications	application	NOUN
ijpds-4459	78	30	in	in	ADP
ijpds-4459	78	31	enhancing	enhance	VERB
ijpds-4459	78	32	therapeutic	therapeutic	ADJ
ijpds-4459	78	33	efficacy	efficacy	NOUN
ijpds-4459	78	34	and	and	CCONJ
ijpds-4459	78	35	minimizing	minimize	VERB
ijpds-4459	78	36	off	off	ADP
ijpds-4459	78	37	-	-	PUNCT
ijpds-4459	78	38	target	target	NOUN
ijpds-4459	78	39	effects	effect	NOUN
ijpds-4459	78	40	.	.	PUNCT
ijpds-4459	79	1	additionally	additionally	ADV
ijpds-4459	79	2	,	,	PUNCT
ijpds-4459	79	3	we	we	PRON
ijpds-4459	79	4	discuss	discuss	VERB
ijpds-4459	79	5	the	the	DET
ijpds-4459	79	6	challenges	challenge	NOUN
ijpds-4459	79	7	and	and	CCONJ
ijpds-4459	79	8	future	future	ADJ
ijpds-4459	79	9	directions	direction	NOUN
ijpds-4459	79	10	in	in	ADP
ijpds-4459	79	11	the	the	DET
ijpds-4459	79	12	development	development	NOUN
ijpds-4459	79	13	of	of	ADP
ijpds-4459	79	14	biomaterial	biomaterial	NOUN
ijpds-4459	79	15	-	-	PUNCT
ijpds-4459	79	16	based	base	VERB
ijpds-4459	79	17	strategies	strategy	NOUN
ijpds-4459	79	18	to	to	PART
ijpds-4459	79	19	overcome	overcome	VERB
ijpds-4459	79	20	obstacles	obstacle	NOUN
ijpds-4459	79	21	faced	face	VERB
ijpds-4459	79	22	in	in	ADP
ijpds-4459	79	23	cancer	cancer	NOUN
ijpds-4459	79	24	treatment	treatment	NOUN
ijpds-4459	79	25	.	.	PUNCT
ijpds-4459	80	1	method	method	NOUN
ijpds-4459	80	2	and	and	CCONJ
ijpds-4459	80	3	materials	material	NOUN
ijpds-4459	80	4	in	in	ADP
ijpds-4459	80	5	conducting	conduct	VERB
ijpds-4459	80	6	this	this	DET
ijpds-4459	80	7	review	review	NOUN
ijpds-4459	80	8	on	on	ADP
ijpds-4459	80	9	"	"	PUNCT
ijpds-4459	80	10	emerging	emerge	VERB
ijpds-4459	80	11	trends	trend	NOUN
ijpds-4459	80	12	in	in	ADP
ijpds-4459	80	13	biomaterials	biomaterial	NOUN
ijpds-4459	80	14	for	for	ADP
ijpds-4459	80	15	cancer	cancer	NOUN
ijpds-4459	80	16	immunotherapy	immunotherapy	NOUN
ijpds-4459	80	17	and	and	CCONJ
ijpds-4459	80	18	genome	genome	NOUN
ijpds-4459	80	19	editing	editing	NOUN
ijpds-4459	80	20	,	,	PUNCT
ijpds-4459	80	21	"	"	PUNCT
ijpds-4459	80	22	an	an	DET
ijpds-4459	80	23	extensive	extensive	ADJ
ijpds-4459	80	24	examination	examination	NOUN
ijpds-4459	80	25	of	of	ADP
ijpds-4459	80	26	available	available	ADJ
ijpds-4459	80	27	literature	literature	NOUN
ijpds-4459	80	28	was	be	AUX
ijpds-4459	80	29	carried	carry	VERB
ijpds-4459	80	30	out	out	ADP
ijpds-4459	80	31	,	,	PUNCT
ijpds-4459	80	32	focusing	focus	VERB
ijpds-4459	80	33	on	on	ADP
ijpds-4459	80	34	the	the	DET
ijpds-4459	80	35	integration	integration	NOUN
ijpds-4459	80	36	of	of	ADP
ijpds-4459	80	37	immune	immune	ADJ
ijpds-4459	80	38	system	system	NOUN
ijpds-4459	80	39	enhancement	enhancement	NOUN
ijpds-4459	80	40	and	and	CCONJ
ijpds-4459	80	41	genome	genome	NOUN
ijpds-4459	80	42	editing	editing	NOUN
ijpds-4459	80	43	technologies	technology	NOUN
ijpds-4459	80	44	in	in	ADP
ijpds-4459	80	45	cancer	cancer	NOUN
ijpds-4459	80	46	treatment	treatment	NOUN
ijpds-4459	80	47	.	.	PUNCT
ijpds-4459	81	1	primary	primary	ADJ
ijpds-4459	81	2	sources	source	NOUN
ijpds-4459	81	3	included	include	VERB
ijpds-4459	81	4	reputable	reputable	ADJ
ijpds-4459	81	5	journals	journal	NOUN
ijpds-4459	81	6	,	,	PUNCT
ijpds-4459	81	7	scientific	scientific	ADJ
ijpds-4459	81	8	databases	database	NOUN
ijpds-4459	81	9	,	,	PUNCT
ijpds-4459	81	10	and	and	CCONJ
ijpds-4459	81	11	authoritative	authoritative	ADJ
ijpds-4459	81	12	publications	publication	NOUN
ijpds-4459	81	13	in	in	ADP
ijpds-4459	81	14	oncology	oncology	NOUN
ijpds-4459	81	15	,	,	PUNCT
ijpds-4459	81	16	immunotherapy	immunotherapy	NOUN
ijpds-4459	81	17	,	,	PUNCT
ijpds-4459	81	18	and	and	CCONJ
ijpds-4459	81	19	genome	genome	NOUN
ijpds-4459	81	20	editing	editing	NOUN
ijpds-4459	81	21	.	.	PUNCT
ijpds-4459	82	1	the	the	DET
ijpds-4459	82	2	search	search	NOUN
ijpds-4459	82	3	encompassed	encompass	VERB
ijpds-4459	82	4	articles	article	NOUN
ijpds-4459	82	5	published	publish	VERB
ijpds-4459	82	6	up	up	ADP
ijpds-4459	82	7	to	to	ADP
ijpds-4459	82	8	january	january	PROPN
ijpds-4459	82	9	2024	2024	NUM
ijpds-4459	82	10	to	to	PART
ijpds-4459	82	11	ensure	ensure	VERB
ijpds-4459	82	12	the	the	DET
ijpds-4459	82	13	inclusion	inclusion	NOUN
ijpds-4459	82	14	of	of	ADP
ijpds-4459	82	15	the	the	DET
ijpds-4459	82	16	latest	late	ADJ
ijpds-4459	82	17	advancements	advancement	NOUN
ijpds-4459	82	18	.	.	PUNCT
ijpds-4459	83	1	the	the	DET
ijpds-4459	83	2	review	review	NOUN
ijpds-4459	83	3	strategically	strategically	ADV
ijpds-4459	83	4	aimed	aim	VERB
ijpds-4459	83	5	to	to	PART
ijpds-4459	83	6	identify	identify	VERB
ijpds-4459	83	7	pivotal	pivotal	ADJ
ijpds-4459	83	8	studies	study	NOUN
ijpds-4459	83	9	,	,	PUNCT
ijpds-4459	83	10	clinical	clinical	ADJ
ijpds-4459	83	11	trials	trial	NOUN
ijpds-4459	83	12	,	,	PUNCT
ijpds-4459	83	13	and	and	CCONJ
ijpds-4459	83	14	research	research	NOUN
ijpds-4459	83	15	papers	paper	NOUN
ijpds-4459	83	16	elucidating	elucidate	VERB
ijpds-4459	83	17	the	the	DET
ijpds-4459	83	18	transformative	transformative	ADJ
ijpds-4459	83	19	impact	impact	NOUN
ijpds-4459	83	20	of	of	ADP
ijpds-4459	83	21	immune	immune	ADJ
ijpds-4459	83	22	checkpoint	checkpoint	NOUN
ijpds-4459	83	23	inhibitors	inhibitor	NOUN
ijpds-4459	83	24	,	,	PUNCT
ijpds-4459	83	25	adoptive	adoptive	ADJ
ijpds-4459	83	26	t	t	PROPN
ijpds-4459	83	27	cell	cell	NOUN
ijpds-4459	83	28	therapies	therapy	NOUN
ijpds-4459	83	29	,	,	PUNCT
ijpds-4459	83	30	cancer	cancer	NOUN
ijpds-4459	83	31	vaccines	vaccine	NOUN
ijpds-4459	83	32	,	,	PUNCT
ijpds-4459	83	33	and	and	CCONJ
ijpds-4459	83	34	genome	genome	NOUN
ijpds-4459	83	35	editing	editing	NOUN
ijpds-4459	83	36	tools	tool	NOUN
ijpds-4459	83	37	,	,	PUNCT
ijpds-4459	83	38	with	with	ADP
ijpds-4459	83	39	a	a	DET
ijpds-4459	83	40	specific	specific	ADJ
ijpds-4459	83	41	emphasis	emphasis	NOUN
ijpds-4459	83	42	on	on	ADP
ijpds-4459	83	43	the	the	DET
ijpds-4459	83	44	revolutionary	revolutionary	ADJ
ijpds-4459	83	45	crispr	crispr	ADJ
ijpds-4459	83	46	-	-	PUNCT
ijpds-4459	83	47	cas9	cas9	NOUN
ijpds-4459	83	48	system	system	NOUN
ijpds-4459	83	49	in	in	ADP
ijpds-4459	83	50	the	the	DET
ijpds-4459	83	51	oncology	oncology	NOUN
ijpds-4459	83	52	landscape	landscape	NOUN
ijpds-4459	83	53	.	.	PUNCT
ijpds-4459	84	1	meticulous	meticulous	ADJ
ijpds-4459	84	2	curation	curation	NOUN
ijpds-4459	84	3	of	of	ADP
ijpds-4459	84	4	gathered	gather	VERB
ijpds-4459	84	5	information	information	NOUN
ijpds-4459	84	6	sought	seek	VERB
ijpds-4459	84	7	to	to	PART
ijpds-4459	84	8	present	present	VERB
ijpds-4459	84	9	a	a	DET
ijpds-4459	84	10	comprehensive	comprehensive	ADJ
ijpds-4459	84	11	overview	overview	NOUN
ijpds-4459	84	12	,	,	PUNCT
ijpds-4459	84	13	emphasizing	emphasize	VERB
ijpds-4459	84	14	recent	recent	ADJ
ijpds-4459	84	15	breakthroughs	breakthrough	NOUN
ijpds-4459	84	16	,	,	PUNCT
ijpds-4459	84	17	emerging	emerge	VERB
ijpds-4459	84	18	trends	trend	NOUN
ijpds-4459	84	19	,	,	PUNCT
ijpds-4459	84	20	and	and	CCONJ
ijpds-4459	84	21	notable	notable	ADJ
ijpds-4459	84	22	examples	example	NOUN
ijpds-4459	84	23	within	within	ADP
ijpds-4459	84	24	each	each	DET
ijpds-4459	84	25	category	category	NOUN
ijpds-4459	84	26	.	.	PUNCT
ijpds-4459	85	1	the	the	DET
ijpds-4459	85	2	narrative	narrative	NOUN
ijpds-4459	85	3	was	be	AUX
ijpds-4459	85	4	enriched	enrich	VERB
ijpds-4459	85	5	by	by	ADP
ijpds-4459	85	6	incorporating	incorporate	VERB
ijpds-4459	85	7	specific	specific	ADJ
ijpds-4459	85	8	examples	example	NOUN
ijpds-4459	85	9	related	relate	VERB
ijpds-4459	85	10	to	to	ADP
ijpds-4459	85	11	lung	lung	NOUN
ijpds-4459	85	12	cancer	cancer	NOUN
ijpds-4459	85	13	,	,	PUNCT
ijpds-4459	85	14	breast	breast	NOUN
ijpds-4459	85	15	cancer	cancer	NOUN
ijpds-4459	85	16	,	,	PUNCT
ijpds-4459	85	17	and	and	CCONJ
ijpds-4459	85	18	prostate	prostate	NOUN
ijpds-4459	85	19	cancer	cancer	NOUN
ijpds-4459	85	20	,	,	PUNCT
ijpds-4459	85	21	providing	provide	VERB
ijpds-4459	85	22	a	a	DET
ijpds-4459	85	23	nuanced	nuanced	ADJ
ijpds-4459	85	24	perspective	perspective	NOUN
ijpds-4459	85	25	on	on	ADP
ijpds-4459	85	26	the	the	DET
ijpds-4459	85	27	application	application	NOUN
ijpds-4459	85	28	of	of	ADP
ijpds-4459	85	29	these	these	DET
ijpds-4459	85	30	technologies	technology	NOUN
ijpds-4459	85	31	across	across	ADP
ijpds-4459	85	32	various	various	ADJ
ijpds-4459	85	33	cancer	cancer	NOUN
ijpds-4459	85	34	types	type	NOUN
ijpds-4459	85	35	.	.	PUNCT
ijpds-4459	86	1	beyond	beyond	ADP
ijpds-4459	86	2	academic	academic	ADJ
ijpds-4459	86	3	sources	source	NOUN
ijpds-4459	86	4	,	,	PUNCT
ijpds-4459	86	5	reports	report	NOUN
ijpds-4459	86	6	from	from	ADP
ijpds-4459	86	7	reputable	reputable	ADJ
ijpds-4459	86	8	medical	medical	ADJ
ijpds-4459	86	9	and	and	CCONJ
ijpds-4459	86	10	scientific	scientific	ADJ
ijpds-4459	86	11	organizations	organization	NOUN
ijpds-4459	86	12	,	,	PUNCT
ijpds-4459	86	13	scrutiny	scrutiny	NOUN
ijpds-4459	86	14	of	of	ADP
ijpds-4459	86	15	clinical	clinical	ADJ
ijpds-4459	86	16	trial	trial	NOUN
ijpds-4459	86	17	databases	database	NOUN
ijpds-4459	86	18	,	,	PUNCT
ijpds-4459	86	19	and	and	CCONJ
ijpds-4459	86	20	exploration	exploration	NOUN
ijpds-4459	86	21	of	of	ADP
ijpds-4459	86	22	official	official	ADJ
ijpds-4459	86	23	regulatory	regulatory	ADJ
ijpds-4459	86	24	publications	publication	NOUN
ijpds-4459	86	25	ensured	ensure	VERB
ijpds-4459	86	26	a	a	DET
ijpds-4459	86	27	well	well	ADV
ijpds-4459	86	28	-	-	PUNCT
ijpds-4459	86	29	rounded	rounded	ADJ
ijpds-4459	86	30	and	and	CCONJ
ijpds-4459	86	31	evidence	evidence	NOUN
ijpds-4459	86	32	-	-	PUNCT
ijpds-4459	86	33	based	base	VERB
ijpds-4459	86	34	approach	approach	NOUN
ijpds-4459	86	35	.	.	PUNCT
ijpds-4459	87	1	the	the	DET
ijpds-4459	87	2	synthesis	synthesis	NOUN
ijpds-4459	87	3	of	of	ADP
ijpds-4459	87	4	this	this	DET
ijpds-4459	87	5	information	information	NOUN
ijpds-4459	87	6	aimed	aim	VERB
ijpds-4459	87	7	to	to	PART
ijpds-4459	87	8	provide	provide	VERB
ijpds-4459	87	9	readers	reader	NOUN
ijpds-4459	87	10	with	with	ADP
ijpds-4459	87	11	a	a	DET
ijpds-4459	87	12	clear	clear	ADJ
ijpds-4459	87	13	understanding	understanding	NOUN
ijpds-4459	87	14	of	of	ADP
ijpds-4459	87	15	the	the	DET
ijpds-4459	87	16	current	current	ADJ
ijpds-4459	87	17	landscape	landscape	NOUN
ijpds-4459	87	18	,	,	PUNCT
ijpds-4459	87	19	challenges	challenge	NOUN
ijpds-4459	87	20	faced	face	VERB
ijpds-4459	87	21	,	,	PUNCT
ijpds-4459	87	22	and	and	CCONJ
ijpds-4459	87	23	future	future	ADJ
ijpds-4459	87	24	directions	direction	NOUN
ijpds-4459	87	25	in	in	ADP
ijpds-4459	87	26	the	the	DET
ijpds-4459	87	27	dynamic	dynamic	ADJ
ijpds-4459	87	28	intersection	intersection	NOUN
ijpds-4459	87	29	of	of	ADP
ijpds-4459	87	30	immune	immune	ADJ
ijpds-4459	87	31	system	system	NOUN
ijpds-4459	87	32	modulation	modulation	NOUN
ijpds-4459	87	33	and	and	CCONJ
ijpds-4459	87	34	genome	genome	NOUN
ijpds-4459	87	35	editing	editing	NOUN
ijpds-4459	87	36	,	,	PUNCT
ijpds-4459	87	37	propelling	propel	VERB
ijpds-4459	87	38	advancements	advancement	NOUN
ijpds-4459	87	39	in	in	ADP
ijpds-4459	87	40	cancer	cancer	NOUN
ijpds-4459	87	41	therapies	therapy	NOUN
ijpds-4459	87	42	.	.	PUNCT
ijpds-4459	88	1	the	the	DET
ijpds-4459	88	2	methodology	methodology	NOUN
ijpds-4459	88	3	placed	place	VERB
ijpds-4459	88	4	a	a	DET
ijpds-4459	88	5	premium	premium	NOUN
ijpds-4459	88	6	on	on	ADP
ijpds-4459	88	7	accuracy	accuracy	NOUN
ijpds-4459	88	8	,	,	PUNCT
ijpds-4459	88	9	relevance	relevance	NOUN
ijpds-4459	88	10	,	,	PUNCT
ijpds-4459	88	11	and	and	CCONJ
ijpds-4459	88	12	the	the	DET
ijpds-4459	88	13	inclusion	inclusion	NOUN
ijpds-4459	88	14	of	of	ADP
ijpds-4459	88	15	diverse	diverse	ADJ
ijpds-4459	88	16	perspectives	perspective	NOUN
ijpds-4459	88	17	,	,	PUNCT
ijpds-4459	88	18	contributing	contribute	VERB
ijpds-4459	88	19	meaningfully	meaningfully	ADV
ijpds-4459	88	20	to	to	ADP
ijpds-4459	88	21	the	the	DET
ijpds-4459	88	22	ongoing	ongoing	ADJ
ijpds-4459	88	23	scholarly	scholarly	ADJ
ijpds-4459	88	24	conversation	conversation	NOUN
ijpds-4459	88	25	in	in	ADP
ijpds-4459	88	26	this	this	DET
ijpds-4459	88	27	transformative	transformative	ADJ
ijpds-4459	88	28	field	field	NOUN
ijpds-4459	88	29	of	of	ADP
ijpds-4459	88	30	research	research	NOUN
ijpds-4459	88	31	.	.	PUNCT
ijpds-4459	89	1	biomaterials	biomaterial	NOUN
ijpds-4459	89	2	for	for	ADP
ijpds-4459	89	3	cancer	cancer	NOUN
ijpds-4459	89	4	immunotherapy	immunotherapy	NOUN
ijpds-4459	89	5	1	1	NUM
ijpds-4459	89	6	.	.	PUNCT
ijpds-4459	89	7	immune	immune	ADJ
ijpds-4459	89	8	modulatory	modulatory	NOUN
ijpds-4459	89	9	biomaterials	biomaterial	NOUN
ijpds-4459	89	10	:	:	PUNCT
ijpds-4459	89	11	immune	immune	ADJ
ijpds-4459	89	12	modulatory	modulatory	NOUN
ijpds-4459	89	13	biomaterials	biomaterial	NOUN
ijpds-4459	89	14	are	be	AUX
ijpds-4459	89	15	ingeniously	ingeniously	ADV
ijpds-4459	89	16	designed	design	VERB
ijpds-4459	89	17	to	to	PART
ijpds-4459	89	18	manipulate	manipulate	VERB
ijpds-4459	89	19	the	the	DET
ijpds-4459	89	20	immune	immune	ADJ
ijpds-4459	89	21	response	response	NOUN
ijpds-4459	89	22	,	,	PUNCT
ijpds-4459	89	23	creating	create	VERB
ijpds-4459	89	24	a	a	DET
ijpds-4459	89	25	favorable	favorable	ADJ
ijpds-4459	89	26	microenvironment	microenvironment	NOUN
ijpds-4459	89	27	conducive	conducive	ADJ
ijpds-4459	89	28	to	to	ADP
ijpds-4459	89	29	the	the	DET
ijpds-4459	89	30	activation	activation	NOUN
ijpds-4459	89	31	of	of	ADP
ijpds-4459	89	32	anti	anti	ADJ
ijpds-4459	89	33	-	-	ADJ
ijpds-4459	89	34	tumor	tumor	ADJ
ijpds-4459	89	35	immune	immune	ADJ
ijpds-4459	89	36	cells	cell	NOUN
ijpds-4459	89	37	[	[	X
ijpds-4459	89	38	17	17	NUM
ijpds-4459	89	39	]	]	PUNCT
ijpds-4459	89	40	.	.	PUNCT
ijpds-4459	90	1	their	their	PRON
ijpds-4459	90	2	pivotal	pivotal	ADJ
ijpds-4459	90	3	role	role	NOUN
ijpds-4459	90	4	in	in	ADP
ijpds-4459	90	5	elevating	elevate	VERB
ijpds-4459	90	6	the	the	DET
ijpds-4459	90	7	efficacy	efficacy	NOUN
ijpds-4459	90	8	of	of	ADP
ijpds-4459	90	9	cancer	cancer	NOUN
ijpds-4459	90	10	immunotherapy	immunotherapy	NOUN
ijpds-4459	90	11	is	be	AUX
ijpds-4459	90	12	evident	evident	ADJ
ijpds-4459	90	13	through	through	ADP
ijpds-4459	90	14	their	their	PRON
ijpds-4459	90	15	ability	ability	NOUN
ijpds-4459	90	16	to	to	PART
ijpds-4459	90	17	deliver	deliver	VERB
ijpds-4459	90	18	immune	immune	ADJ
ijpds-4459	90	19	checkpoint	checkpoint	NOUN
ijpds-4459	90	20	inhibitors	inhibitor	NOUN
ijpds-4459	90	21	and	and	CCONJ
ijpds-4459	90	22	immune	immune	NOUN
ijpds-4459	90	23	-	-	PUNCT
ijpds-4459	90	24	stimulating	stimulate	VERB
ijpds-4459	90	25	cytokines	cytokine	NOUN
ijpds-4459	90	26	with	with	ADP
ijpds-4459	90	27	precision	precision	NOUN
ijpds-4459	90	28	.	.	PUNCT
ijpds-4459	91	1	these	these	DET
ijpds-4459	91	2	biomaterials	biomaterial	NOUN
ijpds-4459	91	3	are	be	AUX
ijpds-4459	91	4	meticulously	meticulously	ADV
ijpds-4459	91	5	engineered	engineer	VERB
ijpds-4459	91	6	to	to	PART
ijpds-4459	91	7	release	release	VERB
ijpds-4459	91	8	therapeutic	therapeutic	ADJ
ijpds-4459	91	9	agents	agent	NOUN
ijpds-4459	91	10	in	in	ADP
ijpds-4459	91	11	a	a	DET
ijpds-4459	91	12	sustained	sustain	VERB
ijpds-4459	91	13	and	and	CCONJ
ijpds-4459	91	14	controlled	control	VERB
ijpds-4459	91	15	manner	manner	NOUN
ijpds-4459	91	16	,	,	PUNCT
ijpds-4459	91	17	ensuring	ensure	VERB
ijpds-4459	91	18	a	a	DET
ijpds-4459	91	19	durable	durable	ADJ
ijpds-4459	91	20	and	and	CCONJ
ijpds-4459	91	21	precisely	precisely	ADV
ijpds-4459	91	22	targeted	target	VERB
ijpds-4459	91	23	immune	immune	ADJ
ijpds-4459	91	24	response	response	NOUN
ijpds-4459	91	25	against	against	ADP
ijpds-4459	91	26	the	the	DET
ijpds-4459	91	27	tumor[22	tumor[22	NOUN
ijpds-4459	91	28	,	,	PUNCT
ijpds-4459	91	29	23	23	NUM
ijpds-4459	91	30	]	]	PUNCT
ijpds-4459	91	31	.	.	PUNCT
ijpds-4459	92	1	nanoparticles	nanoparticle	NOUN
ijpds-4459	92	2	,	,	PUNCT
ijpds-4459	92	3	operating	operate	VERB
ijpds-4459	92	4	at	at	ADP
ijpds-4459	92	5	the	the	DET
ijpds-4459	92	6	nanoscale	nanoscale	NOUN
ijpds-4459	92	7	,	,	PUNCT
ijpds-4459	92	8	stand	stand	VERB
ijpds-4459	92	9	as	as	ADP
ijpds-4459	92	10	formidable	formidable	ADJ
ijpds-4459	92	11	carriers	carrier	NOUN
ijpds-4459	92	12	for	for	ADP
ijpds-4459	92	13	immune	immune	ADJ
ijpds-4459	92	14	modulatory	modulatory	NOUN
ijpds-4459	92	15	agents	agent	NOUN
ijpds-4459	92	16	within	within	ADP
ijpds-4459	92	17	cancer	cancer	NOUN
ijpds-4459	92	18	immunotherapy	immunotherapy	NOUN
ijpds-4459	92	19	[	[	X
ijpds-4459	92	20	24	24	NUM
ijpds-4459	92	21	]	]	PUNCT
ijpds-4459	92	22	.	.	PUNCT
ijpds-4459	93	1	laden	laden	ADJ
ijpds-4459	93	2	with	with	ADP
ijpds-4459	93	3	immune	immune	ADJ
ijpds-4459	93	4	checkpoint	checkpoint	NOUN
ijpds-4459	93	5	inhibitors	inhibitor	NOUN
ijpds-4459	93	6	such	such	ADJ
ijpds-4459	93	7	as	as	ADP
ijpds-4459	93	8	antipd-1	antipd-1	NUM
ijpds-4459	93	9	or	or	CCONJ
ijpds-4459	93	10	anti	anti	ADJ
ijpds-4459	93	11	-	-	ADJ
ijpds-4459	93	12	ctla-4	ctla-4	NOUN
ijpds-4459	93	13	antibodies	antibodie	VERB
ijpds-4459	93	14	,	,	PUNCT
ijpds-4459	93	15	effectively	effectively	ADV
ijpds-4459	93	16	obstruct	obstruct	VERB
ijpds-4459	93	17	inhibitory	inhibitory	ADJ
ijpds-4459	93	18	signals	signal	NOUN
ijpds-4459	93	19	,	,	PUNCT
ijpds-4459	93	20	unleashing	unleash	VERB
ijpds-4459	93	21	the	the	DET
ijpds-4459	93	22	potent	potent	ADJ
ijpds-4459	93	23	activity	activity	NOUN
ijpds-4459	93	24	of	of	ADP
ijpds-4459	93	25	tumorspecific	tumorspecific	PROPN
ijpds-4459	93	26	t	t	PROPN
ijpds-4459	93	27	cells	cell	NOUN
ijpds-4459	93	28	[	[	X
ijpds-4459	93	29	25	25	NUM
ijpds-4459	93	30	,	,	PUNCT
ijpds-4459	93	31	26	26	NUM
ijpds-4459	93	32	]	]	PUNCT
ijpds-4459	93	33	.	.	PUNCT
ijpds-4459	94	1	the	the	DET
ijpds-4459	94	2	controlled	control	VERB
ijpds-4459	94	3	and	and	CCONJ
ijpds-4459	94	4	gradual	gradual	ADJ
ijpds-4459	94	5	release	release	NOUN
ijpds-4459	94	6	of	of	ADP
ijpds-4459	94	7	these	these	DET
ijpds-4459	94	8	antibodies	antibody	NOUN
ijpds-4459	94	9	from	from	ADP
ijpds-4459	94	10	nanoparticles	nanoparticle	NOUN
ijpds-4459	94	11	guarantees	guarantee	NOUN
ijpds-4459	94	12	sustained	sustain	VERB
ijpds-4459	94	13	immune	immune	ADJ
ijpds-4459	94	14	activation	activation	NOUN
ijpds-4459	94	15	,	,	PUNCT
ijpds-4459	94	16	ultimately	ultimately	ADV
ijpds-4459	94	17	leading	lead	VERB
ijpds-4459	94	18	to	to	ADP
ijpds-4459	94	19	profound	profound	ADJ
ijpds-4459	94	20	tumor	tumor	NOUN
ijpds-4459	94	21	regression	regression	NOUN
ijpds-4459	94	22	.	.	PUNCT
ijpds-4459	95	1	on	on	ADP
ijpds-4459	95	2	the	the	DET
ijpds-4459	95	3	other	other	ADJ
ijpds-4459	95	4	hand	hand	NOUN
ijpds-4459	95	5	,	,	PUNCT
ijpds-4459	95	6	hydrogels	hydrogel	NOUN
ijpds-4459	95	7	,	,	PUNCT
ijpds-4459	95	8	intricate	intricate	ADJ
ijpds-4459	95	9	three	three	NUM
ijpds-4459	95	10	-	-	PUNCT
ijpds-4459	95	11	dimensional	dimensional	ADJ
ijpds-4459	95	12	networks	network	NOUN
ijpds-4459	95	13	of	of	ADP
ijpds-4459	95	14	crosslinked	crosslinked	ADJ
ijpds-4459	95	15	polymers	polymer	NOUN
ijpds-4459	95	16	,	,	PUNCT
ijpds-4459	95	17	serve	serve	VERB
ijpds-4459	95	18	as	as	ADP
ijpds-4459	95	19	exceptional	exceptional	ADJ
ijpds-4459	95	20	vehicles	vehicle	NOUN
ijpds-4459	95	21	for	for	ADP
ijpds-4459	95	22	encapsulating	encapsulate	VERB
ijpds-4459	95	23	and	and	CCONJ
ijpds-4459	95	24	releasing	release	VERB
ijpds-4459	95	25	immune	immune	NOUN
ijpds-4459	95	26	-	-	PUNCT
ijpds-4459	95	27	stimulating	stimulate	VERB
ijpds-4459	95	28	cytokines	cytokine	NOUN
ijpds-4459	95	29	like	like	ADP
ijpds-4459	95	30	interleukins	interleukin	NOUN
ijpds-4459	95	31	(	(	PUNCT
ijpds-4459	95	32	il-2	il-2	NUM
ijpds-4459	95	33	,	,	PUNCT
ijpds-4459	95	34	il-12	il-12	NOUN
ijpds-4459	95	35	)	)	PUNCT
ijpds-4459	95	36	or	or	CCONJ
ijpds-4459	95	37	interferon[27,28	interferon[27,28	PROPN
ijpds-4459	95	38	]	]	PUNCT
ijpds-4459	95	39	.	.	PUNCT
ijpds-4459	96	1	these	these	DET
ijpds-4459	96	2	hydrogels	hydrogel	NOUN
ijpds-4459	96	3	create	create	VERB
ijpds-4459	96	4	a	a	DET
ijpds-4459	96	5	localized	localized	ADJ
ijpds-4459	96	6	depot	depot	NOUN
ijpds-4459	96	7	of	of	ADP
ijpds-4459	96	8	these	these	DET
ijpds-4459	96	9	vital	vital	ADJ
ijpds-4459	96	10	cytokines	cytokine	NOUN
ijpds-4459	96	11	precisely	precisely	ADV
ijpds-4459	96	12	at	at	ADP
ijpds-4459	96	13	the	the	DET
ijpds-4459	96	14	tumor	tumor	NOUN
ijpds-4459	96	15	site	site	NOUN
ijpds-4459	96	16	,	,	PUNCT
ijpds-4459	96	17	thus	thus	ADV
ijpds-4459	96	18	fostering	foster	VERB
ijpds-4459	96	19	the	the	DET
ijpds-4459	96	20	recruitment	recruitment	NOUN
ijpds-4459	96	21	and	and	CCONJ
ijpds-4459	96	22	activation	activation	NOUN
ijpds-4459	96	23	of	of	ADP
ijpds-4459	96	24	immune	immune	ADJ
ijpds-4459	96	25	cells	cell	NOUN
ijpds-4459	96	26	,	,	PUNCT
ijpds-4459	96	27	thereby	thereby	ADV
ijpds-4459	96	28	significantly	significantly	ADV
ijpds-4459	96	29	amplifying	amplify	VERB
ijpds-4459	96	30	the	the	DET
ijpds-4459	96	31	anti	anti	ADJ
ijpds-4459	96	32	-	-	ADJ
ijpds-4459	96	33	tumor	tumor	ADJ
ijpds-4459	96	34	immune	immune	ADJ
ijpds-4459	96	35	response	response	NOUN
ijpds-4459	96	36	.	.	PUNCT
ijpds-4459	97	1	furthermore	furthermore	ADV
ijpds-4459	97	2	,	,	PUNCT
ijpds-4459	97	3	the	the	DET
ijpds-4459	97	4	versatility	versatility	NOUN
ijpds-4459	97	5	of	of	ADP
ijpds-4459	97	6	hydrogels	hydrogel	NOUN
ijpds-4459	97	7	allows	allow	VERB
ijpds-4459	97	8	for	for	ADP
ijpds-4459	97	9	the	the	DET
ijpds-4459	97	10	engineering	engineering	NOUN
ijpds-4459	97	11	of	of	ADP
ijpds-4459	97	12	physical	physical	ADJ
ijpds-4459	97	13	support	support	NOUN
ijpds-4459	97	14	and	and	CCONJ
ijpds-4459	97	15	protection	protection	NOUN
ijpds-4459	97	16	for	for	ADP
ijpds-4459	97	17	immune	immune	ADJ
ijpds-4459	97	18	cells	cell	NOUN
ijpds-4459	97	19	,	,	PUNCT
ijpds-4459	97	20	enhancing	enhance	VERB
ijpds-4459	97	21	their	their	PRON
ijpds-4459	97	22	survival	survival	NOUN
ijpds-4459	97	23	and	and	CCONJ
ijpds-4459	97	24	functionality	functionality	NOUN
ijpds-4459	97	25	within	within	ADP
ijpds-4459	97	26	the	the	DET
ijpds-4459	97	27	challenging	challenge	VERB
ijpds-4459	97	28	tumor	tumor	NOUN
ijpds-4459	97	29	microenvironment	microenvironment	NOUN
ijpds-4459	97	30	[	[	X
ijpds-4459	97	31	27	27	NUM
ijpds-4459	97	32	]	]	PUNCT
ijpds-4459	97	33	.	.	PUNCT
ijpds-4459	98	1	these	these	DET
ijpds-4459	98	2	advancements	advancement	NOUN
ijpds-4459	98	3	in	in	ADP
ijpds-4459	98	4	biomaterials	biomaterial	NOUN
ijpds-4459	98	5	hold	hold	VERB
ijpds-4459	98	6	great	great	ADJ
ijpds-4459	98	7	promise	promise	NOUN
ijpds-4459	98	8	in	in	ADP
ijpds-4459	98	9	revolutionizing	revolutionize	VERB
ijpds-4459	98	10	the	the	DET
ijpds-4459	98	11	landscape	landscape	NOUN
ijpds-4459	98	12	of	of	ADP
ijpds-4459	98	13	cancer	cancer	NOUN
ijpds-4459	98	14	immunotherapy	immunotherapy	NOUN
ijpds-4459	98	15	,	,	PUNCT
ijpds-4459	98	16	offering	offer	VERB
ijpds-4459	98	17	new	new	ADJ
ijpds-4459	98	18	avenues	avenue	NOUN
ijpds-4459	98	19	to	to	PART
ijpds-4459	98	20	combat	combat	VERB
ijpds-4459	98	21	cancer	cancer	NOUN
ijpds-4459	98	22	with	with	ADP
ijpds-4459	98	23	increased	increase	VERB
ijpds-4459	98	24	precision	precision	NOUN
ijpds-4459	98	25	and	and	CCONJ
ijpds-4459	98	26	effectiveness	effectiveness	NOUN
ijpds-4459	98	27	.	.	PUNCT
ijpds-4459	99	1	bhat	bhat	PROPN
ijpds-4459	99	2	&	&	CCONJ
ijpds-4459	99	3	shanbhag	shanbhag	NOUN
ijpds-4459	99	4	biomaterials	biomaterial	NOUN
ijpds-4459	99	5	:	:	PUNCT
ijpds-4459	99	6	revolutionizing	revolutionize	VERB
ijpds-4459	99	7	cancer	cancer	NOUN
ijpds-4459	99	8	immunotherapy	immunotherapy	NOUN
ijpds-4459	99	9	and	and	CCONJ
ijpds-4459	99	10	genomics	genomics	NOUN
ijpds-4459	99	11	vol	vol	NOUN
ijpds-4459	99	12	3	3	NUM
ijpds-4459	99	13	|	|	NOUN
ijpds-4459	99	14	issue	issue	NOUN
ijpds-4459	99	15	2	2	NUM
ijpds-4459	99	16	|	|	ADV
ijpds-4459	99	17	apr	apr	NOUN
ijpds-4459	99	18	–	–	PUNCT
ijpds-4459	99	19	jun	jun	PROPN
ijpds-4459	99	20	2024	2024	NUM
ijpds-4459	99	21	indian	indian	PROPN
ijpds-4459	99	22	j	j	PROPN
ijpds-4459	99	23	pharm	pharm	PROPN
ijpds-4459	99	24	drug	drug	PROPN
ijpds-4459	99	25	studies	study	NOUN
ijpds-4459	99	26	|	|	ADV
ijpds-4459	99	27	39	39	NUM
ijpds-4459	99	28	2	2	NUM
ijpds-4459	99	29	.	.	PUNCT
ijpds-4459	100	1	cancer	cancer	NOUN
ijpds-4459	100	2	vaccines	vaccine	NOUN
ijpds-4459	100	3	:	:	PUNCT
ijpds-4459	100	4	biomaterial	biomaterial	ADJ
ijpds-4459	100	5	-	-	PUNCT
ijpds-4459	100	6	based	base	VERB
ijpds-4459	100	7	cancer	cancer	NOUN
ijpds-4459	100	8	vaccines	vaccine	NOUN
ijpds-4459	100	9	have	have	AUX
ijpds-4459	100	10	emerged	emerge	VERB
ijpds-4459	100	11	as	as	ADP
ijpds-4459	100	12	a	a	DET
ijpds-4459	100	13	compelling	compelling	ADJ
ijpds-4459	100	14	approach	approach	NOUN
ijpds-4459	100	15	to	to	PART
ijpds-4459	100	16	augment	augment	VERB
ijpds-4459	100	17	the	the	DET
ijpds-4459	100	18	body	body	NOUN
ijpds-4459	100	19	immune	immune	ADJ
ijpds-4459	100	20	response	response	NOUN
ijpds-4459	100	21	against	against	ADP
ijpds-4459	100	22	cancer	cancer	NOUN
ijpds-4459	100	23	cells	cell	NOUN
ijpds-4459	100	24	[	[	X
ijpds-4459	100	25	28	28	NUM
ijpds-4459	100	26	]	]	PUNCT
ijpds-4459	100	27	.	.	PUNCT
ijpds-4459	101	1	these	these	DET
ijpds-4459	101	2	innovative	innovative	ADJ
ijpds-4459	101	3	vaccines	vaccine	NOUN
ijpds-4459	101	4	are	be	AUX
ijpds-4459	101	5	designed	design	VERB
ijpds-4459	101	6	to	to	PART
ijpds-4459	101	7	bolster	bolster	VERB
ijpds-4459	101	8	antigen	antigen	ADJ
ijpds-4459	101	9	presentation	presentation	NOUN
ijpds-4459	101	10	and	and	CCONJ
ijpds-4459	101	11	stimulate	stimulate	VERB
ijpds-4459	101	12	robust	robust	ADJ
ijpds-4459	101	13	immune	immune	ADJ
ijpds-4459	101	14	reactions	reaction	NOUN
ijpds-4459	101	15	targeting	target	VERB
ijpds-4459	101	16	tumor	tumor	NOUN
ijpds-4459	101	17	-	-	PUNCT
ijpds-4459	101	18	specific	specific	ADJ
ijpds-4459	101	19	antigens	antigen	NOUN
ijpds-4459	101	20	.	.	PUNCT
ijpds-4459	102	1	one	one	NUM
ijpds-4459	102	2	avenue	avenue	NOUN
ijpds-4459	102	3	of	of	ADP
ijpds-4459	102	4	this	this	DET
ijpds-4459	102	5	strategy	strategy	NOUN
ijpds-4459	102	6	involves	involve	VERB
ijpds-4459	102	7	utilizing	utilize	VERB
ijpds-4459	102	8	biomaterials	biomaterial	NOUN
ijpds-4459	102	9	like	like	ADP
ijpds-4459	102	10	liposomes	liposome	NOUN
ijpds-4459	102	11	,	,	PUNCT
ijpds-4459	102	12	nanoparticles	nanoparticle	NOUN
ijpds-4459	102	13	,	,	PUNCT
ijpds-4459	102	14	and	and	CCONJ
ijpds-4459	102	15	virus	virus	NOUN
ijpds-4459	102	16	-	-	PUNCT
ijpds-4459	102	17	like	like	ADJ
ijpds-4459	102	18	particles	particle	NOUN
ijpds-4459	102	19	as	as	ADP
ijpds-4459	102	20	carriers	carrier	NOUN
ijpds-4459	102	21	for	for	ADP
ijpds-4459	102	22	tumor	tumor	NOUN
ijpds-4459	102	23	-	-	PUNCT
ijpds-4459	102	24	specific	specific	ADJ
ijpds-4459	102	25	antigens	antigen	NOUN
ijpds-4459	102	26	[	[	X
ijpds-4459	102	27	29	29	NUM
ijpds-4459	102	28	]	]	PUNCT
ijpds-4459	102	29	.	.	PUNCT
ijpds-4459	103	1	these	these	DET
ijpds-4459	103	2	biomaterial	biomaterial	ADJ
ijpds-4459	103	3	carriers	carrier	NOUN
ijpds-4459	103	4	serve	serve	VERB
ijpds-4459	103	5	a	a	DET
ijpds-4459	103	6	dual	dual	ADJ
ijpds-4459	103	7	purpose	purpose	NOUN
ijpds-4459	103	8	by	by	ADP
ijpds-4459	103	9	safeguarding	safeguard	VERB
ijpds-4459	103	10	the	the	DET
ijpds-4459	103	11	antigens	antigen	NOUN
ijpds-4459	103	12	from	from	ADP
ijpds-4459	103	13	degradation	degradation	NOUN
ijpds-4459	103	14	and	and	CCONJ
ijpds-4459	103	15	enhancing	enhance	VERB
ijpds-4459	103	16	their	their	PRON
ijpds-4459	103	17	uptake	uptake	NOUN
ijpds-4459	103	18	by	by	ADP
ijpds-4459	103	19	antigen	antigen	NOUN
ijpds-4459	103	20	-	-	PUNCT
ijpds-4459	103	21	presenting	present	VERB
ijpds-4459	103	22	cells	cell	NOUN
ijpds-4459	103	23	(	(	PUNCT
ijpds-4459	103	24	apcs)[30	apcs)[30	NOUN
ijpds-4459	103	25	]	]	PUNCT
ijpds-4459	103	26	.	.	PUNCT
ijpds-4459	104	1	this	this	PRON
ijpds-4459	104	2	,	,	PUNCT
ijpds-4459	104	3	in	in	ADP
ijpds-4459	104	4	turn	turn	NOUN
ijpds-4459	104	5	,	,	PUNCT
ijpds-4459	104	6	facilitates	facilitate	VERB
ijpds-4459	104	7	the	the	DET
ijpds-4459	104	8	efficient	efficient	ADJ
ijpds-4459	104	9	presentation	presentation	NOUN
ijpds-4459	104	10	of	of	ADP
ijpds-4459	104	11	these	these	DET
ijpds-4459	104	12	antigens	antigen	NOUN
ijpds-4459	104	13	to	to	ADP
ijpds-4459	104	14	t	t	NOUN
ijpds-4459	104	15	cells	cell	NOUN
ijpds-4459	104	16	,	,	PUNCT
ijpds-4459	104	17	igniting	ignite	VERB
ijpds-4459	104	18	a	a	DET
ijpds-4459	104	19	potent	potent	ADJ
ijpds-4459	104	20	and	and	CCONJ
ijpds-4459	104	21	highly	highly	ADV
ijpds-4459	104	22	specific	specific	ADJ
ijpds-4459	104	23	t	t	NOUN
ijpds-4459	104	24	cell	cell	NOUN
ijpds-4459	104	25	response	response	NOUN
ijpds-4459	104	26	directed	direct	VERB
ijpds-4459	104	27	against	against	ADP
ijpds-4459	104	28	cancer	cancer	NOUN
ijpds-4459	104	29	cells	cell	NOUN
ijpds-4459	104	30	[	[	X
ijpds-4459	104	31	31	31	NUM
ijpds-4459	104	32	]	]	PUNCT
ijpds-4459	104	33	.	.	PUNCT
ijpds-4459	105	1	additionally	additionally	ADV
ijpds-4459	105	2	,	,	PUNCT
ijpds-4459	105	3	biomaterial	biomaterial	ADJ
ijpds-4459	105	4	-	-	PUNCT
ijpds-4459	105	5	based	base	VERB
ijpds-4459	105	6	cancer	cancer	NOUN
ijpds-4459	105	7	vaccines	vaccine	NOUN
ijpds-4459	105	8	can	can	AUX
ijpds-4459	105	9	incorporate	incorporate	VERB
ijpds-4459	105	10	adjuvants	adjuvant	NOUN
ijpds-4459	105	11	,	,	PUNCT
ijpds-4459	105	12	substances	substance	NOUN
ijpds-4459	105	13	known	know	VERB
ijpds-4459	105	14	to	to	PART
ijpds-4459	105	15	enhance	enhance	VERB
ijpds-4459	105	16	immune	immune	ADJ
ijpds-4459	105	17	responses	response	NOUN
ijpds-4459	105	18	to	to	ADP
ijpds-4459	105	19	antigens	antigen	NOUN
ijpds-4459	105	20	.	.	PUNCT
ijpds-4459	106	1	adjuvants	adjuvant	NOUN
ijpds-4459	106	2	like	like	ADP
ijpds-4459	106	3	toll	toll	NOUN
ijpds-4459	106	4	-	-	PUNCT
ijpds-4459	106	5	like	like	ADJ
ijpds-4459	106	6	receptor	receptor	NOUN
ijpds-4459	106	7	(	(	PUNCT
ijpds-4459	106	8	tlr	tlr	PROPN
ijpds-4459	106	9	)	)	PUNCT
ijpds-4459	106	10	agonists	agonist	NOUN
ijpds-4459	106	11	and	and	CCONJ
ijpds-4459	106	12	cytokines	cytokine	NOUN
ijpds-4459	106	13	are	be	AUX
ijpds-4459	106	14	commonly	commonly	ADV
ijpds-4459	106	15	integrated	integrate	VERB
ijpds-4459	106	16	into	into	ADP
ijpds-4459	106	17	these	these	DET
ijpds-4459	106	18	vaccines	vaccine	NOUN
ijpds-4459	106	19	[	[	X
ijpds-4459	106	20	32	32	NUM
ijpds-4459	106	21	]	]	PUNCT
ijpds-4459	106	22	.	.	PUNCT
ijpds-4459	107	1	these	these	DET
ijpds-4459	107	2	adjuvants	adjuvant	NOUN
ijpds-4459	107	3	play	play	VERB
ijpds-4459	107	4	a	a	DET
ijpds-4459	107	5	critical	critical	ADJ
ijpds-4459	107	6	role	role	NOUN
ijpds-4459	107	7	in	in	ADP
ijpds-4459	107	8	further	far	ADV
ijpds-4459	107	9	amplifying	amplify	VERB
ijpds-4459	107	10	the	the	DET
ijpds-4459	107	11	activation	activation	NOUN
ijpds-4459	107	12	of	of	ADP
ijpds-4459	107	13	apcs	apc	NOUN
ijpds-4459	107	14	and	and	CCONJ
ijpds-4459	107	15	t	t	NOUN
ijpds-4459	107	16	cells	cell	NOUN
ijpds-4459	107	17	.	.	PUNCT
ijpds-4459	108	1	by	by	ADP
ijpds-4459	108	2	creating	create	VERB
ijpds-4459	108	3	a	a	DET
ijpds-4459	108	4	pro	pro	ADJ
ijpds-4459	108	5	-	-	ADJ
ijpds-4459	108	6	inflammatory	inflammatory	ADJ
ijpds-4459	108	7	microenvironment	microenvironment	NOUN
ijpds-4459	108	8	,	,	PUNCT
ijpds-4459	108	9	they	they	PRON
ijpds-4459	108	10	assist	assist	VERB
ijpds-4459	108	11	in	in	ADP
ijpds-4459	108	12	the	the	DET
ijpds-4459	108	13	recruitment	recruitment	NOUN
ijpds-4459	108	14	and	and	CCONJ
ijpds-4459	108	15	activation	activation	NOUN
ijpds-4459	108	16	of	of	ADP
ijpds-4459	108	17	immune	immune	ADJ
ijpds-4459	108	18	cells	cell	NOUN
ijpds-4459	108	19	,	,	PUNCT
ijpds-4459	108	20	ultimately	ultimately	ADV
ijpds-4459	108	21	reinforcing	reinforce	VERB
ijpds-4459	108	22	the	the	DET
ijpds-4459	108	23	immune	immune	ADJ
ijpds-4459	108	24	assault	assault	NOUN
ijpds-4459	108	25	on	on	ADP
ijpds-4459	108	26	cancer	cancer	NOUN
ijpds-4459	108	27	[	[	X
ijpds-4459	108	28	33	33	NUM
ijpds-4459	108	29	]	]	PUNCT
ijpds-4459	108	30	.	.	PUNCT
ijpds-4459	109	1	this	this	DET
ijpds-4459	109	2	multifaceted	multifaceted	ADJ
ijpds-4459	109	3	approach	approach	NOUN
ijpds-4459	109	4	harnessing	harness	VERB
ijpds-4459	109	5	biomaterials	biomaterial	NOUN
ijpds-4459	109	6	and	and	CCONJ
ijpds-4459	109	7	adjuvants	adjuvant	NOUN
ijpds-4459	109	8	holds	hold	VERB
ijpds-4459	109	9	substantial	substantial	ADJ
ijpds-4459	109	10	promise	promise	NOUN
ijpds-4459	109	11	in	in	ADP
ijpds-4459	109	12	reshaping	reshape	VERB
ijpds-4459	109	13	the	the	DET
ijpds-4459	109	14	landscape	landscape	NOUN
ijpds-4459	109	15	of	of	ADP
ijpds-4459	109	16	cancer	cancer	NOUN
ijpds-4459	109	17	immunotherapy	immunotherapy	NOUN
ijpds-4459	109	18	,	,	PUNCT
ijpds-4459	109	19	offering	offer	VERB
ijpds-4459	109	20	innovative	innovative	ADJ
ijpds-4459	109	21	strategies	strategy	NOUN
ijpds-4459	109	22	to	to	PART
ijpds-4459	109	23	combat	combat	VERB
ijpds-4459	109	24	cancer	cancer	NOUN
ijpds-4459	109	25	more	more	ADV
ijpds-4459	109	26	effectively	effectively	ADV
ijpds-4459	109	27	and	and	CCONJ
ijpds-4459	109	28	precisely	precisely	ADV
ijpds-4459	109	29	.	.	PUNCT
ijpds-4459	110	1	3	3	X
ijpds-4459	110	2	.	.	NOUN
ijpds-4459	110	3	adoptive	adoptive	ADJ
ijpds-4459	110	4	cell	cell	NOUN
ijpds-4459	110	5	therapies	therapy	NOUN
ijpds-4459	110	6	:	:	PUNCT
ijpds-4459	110	7	adoptive	adoptive	ADJ
ijpds-4459	110	8	cell	cell	NOUN
ijpds-4459	110	9	therapies	therapy	NOUN
ijpds-4459	110	10	(	(	PUNCT
ijpds-4459	110	11	act	act	PROPN
ijpds-4459	110	12	)	)	PUNCT
ijpds-4459	110	13	,	,	PUNCT
ijpds-4459	110	14	a	a	DET
ijpds-4459	110	15	groundbreaking	groundbreake	VERB
ijpds-4459	110	16	approach	approach	NOUN
ijpds-4459	110	17	in	in	ADP
ijpds-4459	110	18	cancer	cancer	NOUN
ijpds-4459	110	19	treatment	treatment	NOUN
ijpds-4459	110	20	,	,	PUNCT
ijpds-4459	110	21	involve	involve	VERB
ijpds-4459	110	22	the	the	DET
ijpds-4459	110	23	isolation	isolation	NOUN
ijpds-4459	110	24	and	and	CCONJ
ijpds-4459	110	25	manipulation	manipulation	NOUN
ijpds-4459	110	26	of	of	ADP
ijpds-4459	110	27	a	a	DET
ijpds-4459	110	28	patient	patient	NOUN
ijpds-4459	110	29	's	's	PART
ijpds-4459	110	30	own	own	ADJ
ijpds-4459	110	31	immune	immune	ADJ
ijpds-4459	110	32	cells	cell	NOUN
ijpds-4459	110	33	,	,	PUNCT
ijpds-4459	110	34	primarily	primarily	ADV
ijpds-4459	110	35	t	t	NOUN
ijpds-4459	110	36	cells	cell	NOUN
ijpds-4459	110	37	,	,	PUNCT
ijpds-4459	110	38	to	to	PART
ijpds-4459	110	39	target	target	VERB
ijpds-4459	110	40	and	and	CCONJ
ijpds-4459	110	41	eliminate	eliminate	VERB
ijpds-4459	110	42	cancer	cancer	NOUN
ijpds-4459	110	43	cells	cell	NOUN
ijpds-4459	110	44	.	.	PUNCT
ijpds-4459	111	1	notably	notably	ADV
ijpds-4459	111	2	,	,	PUNCT
ijpds-4459	111	3	chimeric	chimeric	ADJ
ijpds-4459	111	4	antigen	antigen	ADJ
ijpds-4459	111	5	receptor	receptor	NOUN
ijpds-4459	111	6	(	(	PUNCT
ijpds-4459	111	7	car	car	NOUN
ijpds-4459	111	8	)	)	PUNCT
ijpds-4459	111	9	t	t	NOUN
ijpds-4459	111	10	cell	cell	NOUN
ijpds-4459	111	11	therapy	therapy	NOUN
ijpds-4459	111	12	has	have	AUX
ijpds-4459	111	13	demonstrated	demonstrate	VERB
ijpds-4459	111	14	remarkable	remarkable	ADJ
ijpds-4459	111	15	success	success	NOUN
ijpds-4459	111	16	in	in	ADP
ijpds-4459	111	17	specific	specific	ADJ
ijpds-4459	111	18	cancer	cancer	NOUN
ijpds-4459	111	19	types	type	NOUN
ijpds-4459	111	20	[	[	X
ijpds-4459	111	21	3437	3437	NUM
ijpds-4459	111	22	]	]	PUNCT
ijpds-4459	111	23	.	.	PUNCT
ijpds-4459	112	1	biomaterials	biomaterial	NOUN
ijpds-4459	112	2	play	play	VERB
ijpds-4459	112	3	a	a	DET
ijpds-4459	112	4	pivotal	pivotal	ADJ
ijpds-4459	112	5	role	role	NOUN
ijpds-4459	112	6	in	in	ADP
ijpds-4459	112	7	the	the	DET
ijpds-4459	112	8	ex	ex	ADJ
ijpds-4459	112	9	vivo	vivo	NOUN
ijpds-4459	112	10	engineering	engineering	NOUN
ijpds-4459	112	11	of	of	ADP
ijpds-4459	112	12	car	car	NOUN
ijpds-4459	112	13	-	-	PUNCT
ijpds-4459	112	14	t	t	NOUN
ijpds-4459	112	15	cells	cell	NOUN
ijpds-4459	112	16	,	,	PUNCT
ijpds-4459	112	17	functioning	function	VERB
ijpds-4459	112	18	as	as	ADP
ijpds-4459	112	19	delivery	delivery	NOUN
ijpds-4459	112	20	vehicles	vehicle	NOUN
ijpds-4459	112	21	for	for	ADP
ijpds-4459	112	22	car	car	NOUN
ijpds-4459	112	23	constructs	construct	NOUN
ijpds-4459	112	24	and	and	CCONJ
ijpds-4459	112	25	other	other	ADJ
ijpds-4459	112	26	genetic	genetic	ADJ
ijpds-4459	112	27	material	material	NOUN
ijpds-4459	112	28	into	into	ADP
ijpds-4459	112	29	t	t	NOUN
ijpds-4459	112	30	cells	cell	NOUN
ijpds-4459	112	31	[	[	X
ijpds-4459	112	32	35,36	35,36	NUM
ijpds-4459	112	33	]	]	PUNCT
ijpds-4459	112	34	.	.	PUNCT
ijpds-4459	113	1	this	this	PRON
ijpds-4459	113	2	enables	enable	VERB
ijpds-4459	113	3	the	the	DET
ijpds-4459	113	4	t	t	NOUN
ijpds-4459	113	5	cells	cell	NOUN
ijpds-4459	113	6	to	to	PART
ijpds-4459	113	7	express	express	VERB
ijpds-4459	113	8	specific	specific	ADJ
ijpds-4459	113	9	receptors	receptor	NOUN
ijpds-4459	113	10	(	(	PUNCT
ijpds-4459	113	11	cars	car	NOUN
ijpds-4459	113	12	)	)	PUNCT
ijpds-4459	113	13	designed	design	VERB
ijpds-4459	113	14	to	to	PART
ijpds-4459	113	15	recognize	recognize	VERB
ijpds-4459	113	16	and	and	CCONJ
ijpds-4459	113	17	engage	engage	VERB
ijpds-4459	113	18	cancer	cancer	NOUN
ijpds-4459	113	19	antigens	antigen	NOUN
ijpds-4459	113	20	effectively	effectively	ADV
ijpds-4459	113	21	.	.	PUNCT
ijpds-4459	114	1	nanoparticles	nanoparticle	NOUN
ijpds-4459	114	2	and	and	CCONJ
ijpds-4459	114	3	viral	viral	ADJ
ijpds-4459	114	4	vectors	vector	NOUN
ijpds-4459	114	5	are	be	AUX
ijpds-4459	114	6	frequently	frequently	ADV
ijpds-4459	114	7	employed	employ	VERB
ijpds-4459	114	8	biomaterials	biomaterial	NOUN
ijpds-4459	114	9	,	,	PUNCT
ijpds-4459	114	10	ensuring	ensure	VERB
ijpds-4459	114	11	efficient	efficient	ADJ
ijpds-4459	114	12	gene	gene	NOUN
ijpds-4459	114	13	delivery	delivery	NOUN
ijpds-4459	114	14	into	into	ADP
ijpds-4459	114	15	t	t	NOUN
ijpds-4459	114	16	cells	cell	NOUN
ijpds-4459	114	17	during	during	ADP
ijpds-4459	114	18	this	this	DET
ijpds-4459	114	19	process	process	NOUN
ijpds-4459	114	20	.	.	PUNCT
ijpds-4459	115	1	moreover	moreover	ADV
ijpds-4459	115	2	,	,	PUNCT
ijpds-4459	115	3	the	the	DET
ijpds-4459	115	4	challenges	challenge	NOUN
ijpds-4459	115	5	encountered	encounter	VERB
ijpds-4459	115	6	by	by	ADP
ijpds-4459	115	7	car	car	NOUN
ijpds-4459	115	8	-	-	PUNCT
ijpds-4459	115	9	t	t	NOUN
ijpds-4459	115	10	cells	cell	NOUN
ijpds-4459	115	11	upon	upon	SCONJ
ijpds-4459	115	12	reinfusion	reinfusion	NOUN
ijpds-4459	115	13	into	into	ADP
ijpds-4459	115	14	the	the	DET
ijpds-4459	115	15	patient	patient	NOUN
ijpds-4459	115	16	's	's	PART
ijpds-4459	115	17	body	body	NOUN
ijpds-4459	115	18	within	within	ADP
ijpds-4459	115	19	the	the	DET
ijpds-4459	115	20	complex	complex	ADJ
ijpds-4459	115	21	tumor	tumor	NOUN
ijpds-4459	115	22	microenvironment	microenvironment	NOUN
ijpds-4459	115	23	are	be	AUX
ijpds-4459	115	24	substantial	substantial	ADJ
ijpds-4459	115	25	[	[	PUNCT
ijpds-4459	115	26	35	35	NUM
ijpds-4459	115	27	-	-	SYM
ijpds-4459	115	28	37	37	NUM
ijpds-4459	115	29	]	]	PUNCT
ijpds-4459	115	30	.	.	PUNCT
ijpds-4459	116	1	to	to	PART
ijpds-4459	116	2	address	address	VERB
ijpds-4459	116	3	this	this	PRON
ijpds-4459	116	4	,	,	PUNCT
ijpds-4459	116	5	biomaterials	biomaterial	NOUN
ijpds-4459	116	6	,	,	PUNCT
ijpds-4459	116	7	including	include	VERB
ijpds-4459	116	8	hydrogels	hydrogel	NOUN
ijpds-4459	116	9	and	and	CCONJ
ijpds-4459	116	10	scaffolds	scaffold	NOUN
ijpds-4459	116	11	,	,	PUNCT
ijpds-4459	116	12	can	can	AUX
ijpds-4459	116	13	be	be	AUX
ijpds-4459	116	14	custom	custom	ADV
ijpds-4459	116	15	-	-	PUNCT
ijpds-4459	116	16	designed	design	VERB
ijpds-4459	116	17	to	to	PART
ijpds-4459	116	18	provide	provide	VERB
ijpds-4459	116	19	physical	physical	ADJ
ijpds-4459	116	20	support	support	NOUN
ijpds-4459	116	21	and	and	CCONJ
ijpds-4459	116	22	essential	essential	ADJ
ijpds-4459	116	23	nutrients	nutrient	NOUN
ijpds-4459	116	24	to	to	ADP
ijpds-4459	116	25	car	car	NOUN
ijpds-4459	116	26	-	-	PUNCT
ijpds-4459	116	27	t	t	NOUN
ijpds-4459	116	28	cells	cell	NOUN
ijpds-4459	116	29	.	.	PUNCT
ijpds-4459	117	1	this	this	DET
ijpds-4459	117	2	support	support	NOUN
ijpds-4459	117	3	is	be	AUX
ijpds-4459	117	4	crucial	crucial	ADJ
ijpds-4459	117	5	for	for	ADP
ijpds-4459	117	6	their	their	PRON
ijpds-4459	117	7	survival	survival	NOUN
ijpds-4459	117	8	and	and	CCONJ
ijpds-4459	117	9	persistence	persistence	NOUN
ijpds-4459	117	10	amidst	amidst	ADP
ijpds-4459	117	11	the	the	DET
ijpds-4459	117	12	harsh	harsh	ADJ
ijpds-4459	117	13	conditions	condition	NOUN
ijpds-4459	117	14	of	of	ADP
ijpds-4459	117	15	the	the	DET
ijpds-4459	117	16	tumor	tumor	NOUN
ijpds-4459	117	17	microenvironment	microenvironment	NOUN
ijpds-4459	117	18	.	.	PUNCT
ijpds-4459	118	1	additionally	additionally	ADV
ijpds-4459	118	2	,	,	PUNCT
ijpds-4459	118	3	these	these	DET
ijpds-4459	118	4	biomaterial	biomaterial	NOUN
ijpds-4459	118	5	-	-	PUNCT
ijpds-4459	118	6	based	base	VERB
ijpds-4459	118	7	scaffolds	scaffold	NOUN
ijpds-4459	118	8	can	can	AUX
ijpds-4459	118	9	function	function	VERB
ijpds-4459	118	10	as	as	ADP
ijpds-4459	118	11	reservoirs	reservoir	NOUN
ijpds-4459	118	12	for	for	ADP
ijpds-4459	118	13	cytokines	cytokine	NOUN
ijpds-4459	118	14	and	and	CCONJ
ijpds-4459	118	15	other	other	ADJ
ijpds-4459	118	16	immune	immune	NOUN
ijpds-4459	118	17	-	-	PUNCT
ijpds-4459	118	18	modulating	modulate	VERB
ijpds-4459	118	19	agents	agent	NOUN
ijpds-4459	118	20	,	,	PUNCT
ijpds-4459	118	21	further	far	ADV
ijpds-4459	118	22	enhancing	enhance	VERB
ijpds-4459	118	23	the	the	DET
ijpds-4459	118	24	anti	anti	ADJ
ijpds-4459	118	25	-	-	ADJ
ijpds-4459	118	26	tumor	tumor	ADJ
ijpds-4459	118	27	activity	activity	NOUN
ijpds-4459	118	28	of	of	ADP
ijpds-4459	118	29	car	car	NOUN
ijpds-4459	118	30	-	-	PUNCT
ijpds-4459	118	31	t	t	NOUN
ijpds-4459	118	32	cells	cell	NOUN
ijpds-4459	118	33	[	[	X
ijpds-4459	118	34	34	34	NUM
ijpds-4459	118	35	-	-	SYM
ijpds-4459	118	36	37	37	NUM
ijpds-4459	118	37	]	]	PUNCT
ijpds-4459	118	38	.	.	PUNCT
ijpds-4459	119	1	this	this	DET
ijpds-4459	119	2	multifaceted	multifaceted	ADJ
ijpds-4459	119	3	approach	approach	NOUN
ijpds-4459	119	4	that	that	PRON
ijpds-4459	119	5	combines	combine	VERB
ijpds-4459	119	6	the	the	DET
ijpds-4459	119	7	power	power	NOUN
ijpds-4459	119	8	of	of	ADP
ijpds-4459	119	9	biomaterials	biomaterial	NOUN
ijpds-4459	119	10	with	with	ADP
ijpds-4459	119	11	car	car	NOUN
ijpds-4459	119	12	-	-	PUNCT
ijpds-4459	119	13	t	t	NOUN
ijpds-4459	119	14	cell	cell	NOUN
ijpds-4459	119	15	therapy	therapy	NOUN
ijpds-4459	119	16	holds	hold	VERB
ijpds-4459	119	17	immense	immense	ADJ
ijpds-4459	119	18	promise	promise	NOUN
ijpds-4459	119	19	in	in	ADP
ijpds-4459	119	20	advancing	advance	VERB
ijpds-4459	119	21	the	the	DET
ijpds-4459	119	22	field	field	NOUN
ijpds-4459	119	23	of	of	ADP
ijpds-4459	119	24	cancer	cancer	NOUN
ijpds-4459	119	25	immunotherapy	immunotherapy	NOUN
ijpds-4459	119	26	,	,	PUNCT
ijpds-4459	119	27	offering	offer	VERB
ijpds-4459	119	28	novel	novel	ADJ
ijpds-4459	119	29	strategies	strategy	NOUN
ijpds-4459	119	30	to	to	PART
ijpds-4459	119	31	combat	combat	VERB
ijpds-4459	119	32	cancer	cancer	NOUN
ijpds-4459	119	33	more	more	ADV
ijpds-4459	119	34	effectively	effectively	ADV
ijpds-4459	119	35	by	by	ADP
ijpds-4459	119	36	equipping	equip	VERB
ijpds-4459	119	37	engineered	engineer	VERB
ijpds-4459	119	38	immune	immune	ADJ
ijpds-4459	119	39	cells	cell	NOUN
ijpds-4459	119	40	with	with	ADP
ijpds-4459	119	41	the	the	DET
ijpds-4459	119	42	tools	tool	NOUN
ijpds-4459	119	43	they	they	PRON
ijpds-4459	119	44	need	need	VERB
ijpds-4459	119	45	to	to	PART
ijpds-4459	119	46	navigate	navigate	VERB
ijpds-4459	119	47	and	and	CCONJ
ijpds-4459	119	48	conquer	conquer	VERB
ijpds-4459	119	49	the	the	DET
ijpds-4459	119	50	complex	complex	ADJ
ijpds-4459	119	51	tumor	tumor	NOUN
ijpds-4459	119	52	landscape	landscape	NOUN
ijpds-4459	119	53	.	.	PUNCT
ijpds-4459	120	1	figure	figure	NOUN
ijpds-4459	120	2	1	1	NUM
ijpds-4459	120	3	.	.	PUNCT
ijpds-4459	121	1	biomaterials	biomaterial	NOUN
ijpds-4459	121	2	for	for	ADP
ijpds-4459	121	3	cancer	cancer	NOUN
ijpds-4459	121	4	immunotherapy	immunotherapy	NOUN
ijpds-4459	121	5	.	.	PUNCT
ijpds-4459	122	1	biomaterials	biomaterial	NOUN
ijpds-4459	122	2	for	for	ADP
ijpds-4459	122	3	genome	genome	NOUN
ijpds-4459	122	4	editing	editing	NOUN
ijpds-4459	122	5	biomaterials	biomaterial	NOUN
ijpds-4459	122	6	have	have	AUX
ijpds-4459	122	7	emerged	emerge	VERB
ijpds-4459	122	8	as	as	ADP
ijpds-4459	122	9	essential	essential	ADJ
ijpds-4459	122	10	tools	tool	NOUN
ijpds-4459	122	11	in	in	ADP
ijpds-4459	122	12	the	the	DET
ijpds-4459	122	13	field	field	NOUN
ijpds-4459	122	14	of	of	ADP
ijpds-4459	122	15	genome	genome	NOUN
ijpds-4459	122	16	editing	editing	NOUN
ijpds-4459	122	17	,	,	PUNCT
ijpds-4459	122	18	particularly	particularly	ADV
ijpds-4459	122	19	with	with	ADP
ijpds-4459	122	20	the	the	DET
ijpds-4459	122	21	advent	advent	NOUN
ijpds-4459	122	22	of	of	ADP
ijpds-4459	122	23	crispr	crispr	ADJ
ijpds-4459	122	24	-	-	PUNCT
ijpds-4459	122	25	cas9	cas9	NOUN
ijpds-4459	122	26	technology	technology	NOUN
ijpds-4459	122	27	.	.	PUNCT
ijpds-4459	123	1	genome	genome	NOUN
ijpds-4459	123	2	editing	editing	NOUN
ijpds-4459	123	3	aims	aim	VERB
ijpds-4459	123	4	to	to	PART
ijpds-4459	123	5	precisely	precisely	ADV
ijpds-4459	123	6	modify	modify	VERB
ijpds-4459	123	7	the	the	DET
ijpds-4459	123	8	dna	dna	PROPN
ijpds-4459	123	9	sequence	sequence	NOUN
ijpds-4459	123	10	of	of	ADP
ijpds-4459	123	11	living	live	VERB
ijpds-4459	123	12	organisms	organism	NOUN
ijpds-4459	123	13	,	,	PUNCT
ijpds-4459	123	14	offering	offer	VERB
ijpds-4459	123	15	unprecedented	unprecedented	ADJ
ijpds-4459	123	16	potential	potential	NOUN
ijpds-4459	123	17	for	for	ADP
ijpds-4459	123	18	treating	treat	VERB
ijpds-4459	123	19	genetic	genetic	ADJ
ijpds-4459	123	20	diseases	disease	NOUN
ijpds-4459	123	21	,	,	PUNCT
ijpds-4459	123	22	understanding	understand	VERB
ijpds-4459	123	23	gene	gene	NOUN
ijpds-4459	123	24	function	function	NOUN
ijpds-4459	123	25	,	,	PUNCT
ijpds-4459	123	26	and	and	CCONJ
ijpds-4459	123	27	advancing	advance	VERB
ijpds-4459	123	28	biotechnology	biotechnology	NOUN
ijpds-4459	123	29	.	.	PUNCT
ijpds-4459	124	1	biomaterials	biomaterial	NOUN
ijpds-4459	124	2	play	play	VERB
ijpds-4459	124	3	crucial	crucial	ADJ
ijpds-4459	124	4	roles	role	NOUN
ijpds-4459	124	5	in	in	ADP
ijpds-4459	124	6	facilitating	facilitate	VERB
ijpds-4459	124	7	efficient	efficient	ADJ
ijpds-4459	124	8	and	and	CCONJ
ijpds-4459	124	9	targeted	target	VERB
ijpds-4459	124	10	delivery	delivery	NOUN
ijpds-4459	124	11	of	of	ADP
ijpds-4459	124	12	crispr	crispr	ADJ
ijpds-4459	124	13	-	-	PUNCT
ijpds-4459	124	14	cas9	cas9	NOUN
ijpds-4459	124	15	components	component	NOUN
ijpds-4459	124	16	,	,	PUNCT
ijpds-4459	124	17	protecting	protect	VERB
ijpds-4459	124	18	these	these	DET
ijpds-4459	124	19	components	component	NOUN
ijpds-4459	124	20	from	from	ADP
ijpds-4459	124	21	degradation	degradation	NOUN
ijpds-4459	124	22	,	,	PUNCT
ijpds-4459	124	23	and	and	CCONJ
ijpds-4459	124	24	enhancing	enhance	VERB
ijpds-4459	124	25	gene	gene	NOUN
ijpds-4459	124	26	editing	edit	VERB
ijpds-4459	124	27	efficiency	efficiency	NOUN
ijpds-4459	124	28	[	[	X
ijpds-4459	124	29	12,13	12,13	NUM
ijpds-4459	124	30	]	]	PUNCT
ijpds-4459	124	31	.	.	PUNCT
ijpds-4459	125	1	the	the	DET
ijpds-4459	125	2	various	various	ADJ
ijpds-4459	125	3	types	type	NOUN
ijpds-4459	125	4	of	of	ADP
ijpds-4459	125	5	biomaterials	biomaterial	NOUN
ijpds-4459	125	6	used	use	VERB
ijpds-4459	125	7	in	in	ADP
ijpds-4459	125	8	genome	genome	NOUN
ijpds-4459	125	9	editing	editing	NOUN
ijpds-4459	125	10	are	be	AUX
ijpds-4459	125	11	:	:	PUNCT
ijpds-4459	125	12	1	1	X
ijpds-4459	125	13	.	.	X
ijpds-4459	125	14	delivery	delivery	NOUN
ijpds-4459	125	15	of	of	ADP
ijpds-4459	125	16	crispr	crispr	ADJ
ijpds-4459	125	17	-	-	PUNCT
ijpds-4459	125	18	cas9	cas9	NOUN
ijpds-4459	125	19	components	component	NOUN
ijpds-4459	125	20	:	:	PUNCT
ijpds-4459	125	21	efficiently	efficiently	ADV
ijpds-4459	125	22	delivering	deliver	VERB
ijpds-4459	125	23	the	the	DET
ijpds-4459	125	24	crispr	crispr	ADJ
ijpds-4459	125	25	-	-	PUNCT
ijpds-4459	125	26	cas9	cas9	NOUN
ijpds-4459	125	27	system	system	NOUN
ijpds-4459	125	28	to	to	PART
ijpds-4459	125	29	target	target	VERB
ijpds-4459	125	30	cells	cell	NOUN
ijpds-4459	125	31	or	or	CCONJ
ijpds-4459	125	32	tissues	tissue	NOUN
ijpds-4459	125	33	is	be	AUX
ijpds-4459	125	34	a	a	DET
ijpds-4459	125	35	central	central	ADJ
ijpds-4459	125	36	challenge	challenge	NOUN
ijpds-4459	125	37	in	in	ADP
ijpds-4459	125	38	genome	genome	NOUN
ijpds-4459	125	39	editing	editing	NOUN
ijpds-4459	125	40	,	,	PUNCT
ijpds-4459	125	41	and	and	CCONJ
ijpds-4459	125	42	biomaterials	biomaterial	NOUN
ijpds-4459	125	43	play	play	VERB
ijpds-4459	125	44	a	a	DET
ijpds-4459	125	45	pivotal	pivotal	ADJ
ijpds-4459	125	46	role	role	NOUN
ijpds-4459	125	47	in	in	ADP
ijpds-4459	125	48	overcoming	overcome	VERB
ijpds-4459	125	49	this	this	DET
ijpds-4459	125	50	obstacle	obstacle	NOUN
ijpds-4459	126	1	[	[	X
ijpds-4459	126	2	38	38	NUM
ijpds-4459	126	3	]	]	PUNCT
ijpds-4459	126	4	.	.	PUNCT
ijpds-4459	127	1	these	these	DET
ijpds-4459	127	2	versatile	versatile	ADJ
ijpds-4459	127	3	carriers	carrier	NOUN
ijpds-4459	127	4	encapsulate	encapsulate	VERB
ijpds-4459	127	5	and	and	CCONJ
ijpds-4459	127	6	protect	protect	VERB
ijpds-4459	127	7	essential	essential	ADJ
ijpds-4459	127	8	crispr	crispr	ADJ
ijpds-4459	127	9	-	-	PUNCT
ijpds-4459	127	10	cas9	cas9	NOUN
ijpds-4459	127	11	components	component	NOUN
ijpds-4459	127	12	,	,	PUNCT
ijpds-4459	127	13	including	include	VERB
ijpds-4459	127	14	the	the	DET
ijpds-4459	127	15	cas9	cas9	NOUN
ijpds-4459	127	16	protein	protein	NOUN
ijpds-4459	127	17	or	or	CCONJ
ijpds-4459	127	18	mrna	mrna	PROPN
ijpds-4459	127	19	and	and	CCONJ
ijpds-4459	127	20	guide	guide	VERB
ijpds-4459	127	21	rna	rna	PROPN
ijpds-4459	127	22	(	(	PUNCT
ijpds-4459	127	23	grna	grna	NOUN
ijpds-4459	127	24	)	)	PUNCT
ijpds-4459	127	25	molecules	molecule	NOUN
ijpds-4459	127	26	,	,	PUNCT
ijpds-4459	127	27	ensuring	ensure	VERB
ijpds-4459	127	28	their	their	PRON
ijpds-4459	127	29	successful	successful	ADJ
ijpds-4459	127	30	delivery	delivery	NOUN
ijpds-4459	127	31	to	to	ADP
ijpds-4459	127	32	the	the	DET
ijpds-4459	127	33	desired	desire	VERB
ijpds-4459	127	34	cellular	cellular	ADJ
ijpds-4459	127	35	destinations	destination	NOUN
ijpds-4459	127	36	[	[	X
ijpds-4459	127	37	39	39	NUM
ijpds-4459	127	38	]	]	PUNCT
ijpds-4459	127	39	.	.	PUNCT
ijpds-4459	128	1	three	three	NUM
ijpds-4459	128	2	commonly	commonly	ADV
ijpds-4459	128	3	used	use	VERB
ijpds-4459	128	4	biomaterials	biomaterial	NOUN
ijpds-4459	128	5	in	in	ADP
ijpds-4459	128	6	this	this	DET
ijpds-4459	128	7	context	context	NOUN
ijpds-4459	128	8	are	be	AUX
ijpds-4459	128	9	nanoparticles	nanoparticle	NOUN
ijpds-4459	128	10	,	,	PUNCT
ijpds-4459	128	11	liposomes	liposome	NOUN
ijpds-4459	128	12	,	,	PUNCT
ijpds-4459	128	13	and	and	CCONJ
ijpds-4459	128	14	viral	viral	ADJ
ijpds-4459	128	15	vectors	vector	NOUN
ijpds-4459	128	16	[	[	X
ijpds-4459	128	17	40	40	NUM
ijpds-4459	128	18	]	]	PUNCT
ijpds-4459	128	19	.	.	PUNCT
ijpds-4459	129	1	nanoparticles	nanoparticle	NOUN
ijpds-4459	129	2	made	make	VERB
ijpds-4459	129	3	from	from	ADP
ijpds-4459	129	4	biocompatible	biocompatible	ADJ
ijpds-4459	129	5	materials	material	NOUN
ijpds-4459	129	6	,	,	PUNCT
ijpds-4459	129	7	such	such	ADJ
ijpds-4459	129	8	as	as	ADP
ijpds-4459	129	9	lipids	lipid	NOUN
ijpds-4459	129	10	or	or	CCONJ
ijpds-4459	129	11	polymers	polymer	NOUN
ijpds-4459	129	12	,	,	PUNCT
ijpds-4459	129	13	have	have	AUX
ijpds-4459	129	14	shown	show	VERB
ijpds-4459	129	15	remarkable	remarkable	ADJ
ijpds-4459	129	16	efficacy	efficacy	NOUN
ijpds-4459	129	17	as	as	ADP
ijpds-4459	129	18	carriers	carrier	NOUN
ijpds-4459	129	19	for	for	ADP
ijpds-4459	129	20	crispr	crispr	ADJ
ijpds-4459	129	21	-	-	PUNCT
ijpds-4459	129	22	cas9	cas9	NOUN
ijpds-4459	129	23	components	component	NOUN
ijpds-4459	129	24	.	.	PUNCT
ijpds-4459	130	1	they	they	PRON
ijpds-4459	130	2	bhat	bhat	PROPN
ijpds-4459	130	3	&	&	CCONJ
ijpds-4459	130	4	shanbhag	shanbhag	NOUN
ijpds-4459	130	5	biomaterials	biomaterial	NOUN
ijpds-4459	130	6	:	:	PUNCT
ijpds-4459	130	7	revolutionizing	revolutionize	VERB
ijpds-4459	130	8	cancer	cancer	NOUN
ijpds-4459	130	9	immunotherapy	immunotherapy	NOUN
ijpds-4459	130	10	and	and	CCONJ
ijpds-4459	130	11	genomics	genomics	NOUN
ijpds-4459	130	12	vol	vol	NOUN
ijpds-4459	130	13	3	3	NUM
ijpds-4459	131	1	|	|	NOUN
ijpds-4459	131	2	issue	issue	NOUN
ijpds-4459	131	3	2	2	NUM
ijpds-4459	131	4	|	|	ADV
ijpds-4459	131	5	apr	apr	NOUN
ijpds-4459	131	6	–	–	PUNCT
ijpds-4459	131	7	jun	jun	PROPN
ijpds-4459	131	8	2024	2024	NUM
ijpds-4459	131	9	indian	indian	PROPN
ijpds-4459	131	10	j	j	PROPN
ijpds-4459	131	11	pharm	pharm	PROPN
ijpds-4459	131	12	drug	drug	PROPN
ijpds-4459	131	13	studies	study	NOUN
ijpds-4459	131	14	|	|	ADV
ijpds-4459	131	15	40	40	NUM
ijpds-4459	131	16	protect	protect	VERB
ijpds-4459	131	17	the	the	DET
ijpds-4459	131	18	cargo	cargo	NOUN
ijpds-4459	131	19	from	from	ADP
ijpds-4459	131	20	degradation	degradation	NOUN
ijpds-4459	131	21	and	and	CCONJ
ijpds-4459	131	22	allow	allow	VERB
ijpds-4459	131	23	for	for	ADP
ijpds-4459	131	24	efficient	efficient	ADJ
ijpds-4459	131	25	uptake	uptake	NOUN
ijpds-4459	131	26	by	by	ADP
ijpds-4459	131	27	target	target	NOUN
ijpds-4459	131	28	cells	cell	NOUN
ijpds-4459	131	29	.	.	PUNCT
ijpds-4459	132	1	due	due	ADP
ijpds-4459	132	2	to	to	ADP
ijpds-4459	132	3	the	the	DET
ijpds-4459	132	4	large	large	ADJ
ijpds-4459	132	5	molecular	molecular	ADJ
ijpds-4459	132	6	weight	weight	NOUN
ijpds-4459	132	7	of	of	ADP
ijpds-4459	132	8	the	the	DET
ijpds-4459	132	9	cas9	cas9	NOUN
ijpds-4459	132	10	protein	protein	NOUN
ijpds-4459	132	11	(	(	PUNCT
ijpds-4459	132	12	approximately	approximately	ADV
ijpds-4459	132	13	4.5	4.5	NUM
ijpds-4459	132	14	kb	kb	NOUN
ijpds-4459	132	15	in	in	ADP
ijpds-4459	132	16	genetic	genetic	ADJ
ijpds-4459	132	17	size	size	NOUN
ijpds-4459	132	18	)	)	PUNCT
ijpds-4459	132	19	and	and	CCONJ
ijpds-4459	132	20	its	its	PRON
ijpds-4459	132	21	low	low	ADJ
ijpds-4459	132	22	stability	stability	NOUN
ijpds-4459	132	23	against	against	ADP
ijpds-4459	132	24	serum	serum	NOUN
ijpds-4459	132	25	enzymes	enzyme	NOUN
ijpds-4459	132	26	and	and	CCONJ
ijpds-4459	132	27	proteins	protein	NOUN
ijpds-4459	132	28	,	,	PUNCT
ijpds-4459	132	29	the	the	DET
ijpds-4459	132	30	entry	entry	NOUN
ijpds-4459	132	31	of	of	ADP
ijpds-4459	132	32	the	the	DET
ijpds-4459	132	33	cas9	cas9	PROPN
ijpds-4459	132	34	/	/	SYM
ijpds-4459	132	35	sgrna	sgrna	PROPN
ijpds-4459	132	36	or	or	CCONJ
ijpds-4459	132	37	rnp	rnp	PROPN
ijpds-4459	132	38	complex	complex	NOUN
ijpds-4459	132	39	into	into	ADP
ijpds-4459	132	40	cells	cell	NOUN
ijpds-4459	132	41	is	be	AUX
ijpds-4459	132	42	challenging	challenge	VERB
ijpds-4459	132	43	[	[	X
ijpds-4459	132	44	41,42	41,42	NOUN
ijpds-4459	132	45	]	]	PUNCT
ijpds-4459	132	46	.	.	PUNCT
ijpds-4459	133	1	however	however	ADV
ijpds-4459	133	2	,	,	PUNCT
ijpds-4459	133	3	nanoparticle	nanoparticle	NOUN
ijpds-4459	133	4	delivery	delivery	NOUN
ijpds-4459	133	5	systems	system	NOUN
ijpds-4459	133	6	,	,	PUNCT
ijpds-4459	133	7	such	such	ADJ
ijpds-4459	133	8	as	as	ADP
ijpds-4459	133	9	lipidbased	lipidbased	ADJ
ijpds-4459	133	10	nanoparticles	nanoparticle	NOUN
ijpds-4459	133	11	and	and	CCONJ
ijpds-4459	133	12	cationic	cationic	ADJ
ijpds-4459	133	13	polymer	polymer	NOUN
ijpds-4459	133	14	nanoparticles	nanoparticle	NOUN
ijpds-4459	133	15	,	,	PUNCT
ijpds-4459	133	16	have	have	AUX
ijpds-4459	133	17	been	be	AUX
ijpds-4459	133	18	developed	develop	VERB
ijpds-4459	133	19	to	to	PART
ijpds-4459	133	20	address	address	VERB
ijpds-4459	133	21	these	these	DET
ijpds-4459	133	22	challenges	challenge	NOUN
ijpds-4459	133	23	.	.	PUNCT
ijpds-4459	134	1	these	these	DET
ijpds-4459	134	2	delivery	delivery	NOUN
ijpds-4459	134	3	systems	system	NOUN
ijpds-4459	134	4	can	can	AUX
ijpds-4459	134	5	be	be	AUX
ijpds-4459	134	6	modified	modify	VERB
ijpds-4459	134	7	to	to	PART
ijpds-4459	134	8	target	target	VERB
ijpds-4459	134	9	specific	specific	ADJ
ijpds-4459	134	10	cell	cell	NOUN
ijpds-4459	134	11	types	type	NOUN
ijpds-4459	134	12	,	,	PUNCT
ijpds-4459	134	13	reducing	reduce	VERB
ijpds-4459	134	14	off	off	ADP
ijpds-4459	134	15	-	-	PUNCT
ijpds-4459	134	16	target	target	NOUN
ijpds-4459	134	17	effects	effect	NOUN
ijpds-4459	134	18	and	and	CCONJ
ijpds-4459	134	19	improving	improve	VERB
ijpds-4459	134	20	gene	gene	NOUN
ijpds-4459	134	21	editing	edit	VERB
ijpds-4459	134	22	precision	precision	NOUN
ijpds-4459	134	23	.	.	PUNCT
ijpds-4459	135	1	for	for	ADP
ijpds-4459	135	2	instance	instance	NOUN
ijpds-4459	135	3	,	,	PUNCT
ijpds-4459	135	4	a	a	DET
ijpds-4459	135	5	dna	dna	NOUN
ijpds-4459	135	6	nanocell[nc]-based	nanocell[nc]-base	VERB
ijpds-4459	135	7	delivery	delivery	NOUN
ijpds-4459	135	8	system	system	NOUN
ijpds-4459	135	9	has	have	AUX
ijpds-4459	135	10	been	be	AUX
ijpds-4459	135	11	shown	show	VERB
ijpds-4459	135	12	to	to	PART
ijpds-4459	135	13	efficiently	efficiently	ADV
ijpds-4459	135	14	load	load	VERB
ijpds-4459	135	15	the	the	DET
ijpds-4459	135	16	cas12a	cas12a	NOUN
ijpds-4459	135	17	/	/	SYM
ijpds-4459	135	18	crrna	crrna	NOUN
ijpds-4459	135	19	rnp	rnp	PROPN
ijpds-4459	136	1	[	[	X
ijpds-4459	136	2	42	42	NUM
ijpds-4459	136	3	,	,	PUNCT
ijpds-4459	136	4	43	43	NUM
ijpds-4459	136	5	]	]	PUNCT
ijpds-4459	136	6	.	.	PUNCT
ijpds-4459	137	1	additionally	additionally	ADV
ijpds-4459	137	2	,	,	PUNCT
ijpds-4459	137	3	systemic	systemic	ADJ
ijpds-4459	137	4	nanoparticle	nanoparticle	NOUN
ijpds-4459	137	5	delivery	delivery	NOUN
ijpds-4459	137	6	of	of	ADP
ijpds-4459	137	7	crisprcas9	crisprcas9	NOUN
ijpds-4459	137	8	ribonucleoproteins	ribonucleoprotein	NOUN
ijpds-4459	137	9	has	have	AUX
ijpds-4459	137	10	demonstrated	demonstrate	VERB
ijpds-4459	137	11	effective	effective	ADJ
ijpds-4459	137	12	tissuespecific	tissuespecific	NOUN
ijpds-4459	137	13	genome	genome	NOUN
ijpds-4459	137	14	editing	editing	NOUN
ijpds-4459	137	15	.	.	PUNCT
ijpds-4459	138	1	the	the	DET
ijpds-4459	138	2	development	development	NOUN
ijpds-4459	138	3	of	of	ADP
ijpds-4459	138	4	nanoparticlebased	nanoparticlebase	VERB
ijpds-4459	138	5	technology	technology	NOUN
ijpds-4459	138	6	for	for	ADP
ijpds-4459	138	7	crispr	crispr	ADJ
ijpds-4459	138	8	-	-	PUNCT
ijpds-4459	138	9	cas9	cas9	NOUN
ijpds-4459	138	10	delivery	delivery	NOUN
ijpds-4459	138	11	holds	hold	VERB
ijpds-4459	138	12	promising	promise	VERB
ijpds-4459	138	13	prospects	prospect	NOUN
ijpds-4459	138	14	for	for	ADP
ijpds-4459	138	15	clinical	clinical	ADJ
ijpds-4459	138	16	gene	gene	NOUN
ijpds-4459	138	17	editing	editing	NOUN
ijpds-4459	138	18	,	,	PUNCT
ijpds-4459	138	19	as	as	SCONJ
ijpds-4459	138	20	evidenced	evidence	VERB
ijpds-4459	138	21	by	by	ADP
ijpds-4459	138	22	the	the	DET
ijpds-4459	138	23	completion	completion	NOUN
ijpds-4459	138	24	of	of	ADP
ijpds-4459	138	25	the	the	DET
ijpds-4459	138	26	first	first	ADJ
ijpds-4459	138	27	crispr	crispr	ADJ
ijpds-4459	138	28	/	/	SYM
ijpds-4459	138	29	cas9	cas9	NOUN
ijpds-4459	138	30	clinical	clinical	ADJ
ijpds-4459	138	31	trial	trial	NOUN
ijpds-4459	138	32	in	in	ADP
ijpds-4459	138	33	2016	2016	NUM
ijpds-4459	138	34	[	[	X
ijpds-4459	138	35	44	44	NUM
ijpds-4459	138	36	]	]	PUNCT
ijpds-4459	138	37	.	.	PUNCT
ijpds-4459	139	1	furthermore	furthermore	ADV
ijpds-4459	139	2	,	,	PUNCT
ijpds-4459	139	3	various	various	ADJ
ijpds-4459	139	4	studies	study	NOUN
ijpds-4459	139	5	have	have	AUX
ijpds-4459	139	6	highlighted	highlight	VERB
ijpds-4459	139	7	the	the	DET
ijpds-4459	139	8	potential	potential	NOUN
ijpds-4459	139	9	of	of	ADP
ijpds-4459	139	10	nanoparticle	nanoparticle	NOUN
ijpds-4459	139	11	delivery	delivery	NOUN
ijpds-4459	139	12	systems	system	NOUN
ijpds-4459	139	13	for	for	ADP
ijpds-4459	139	14	the	the	DET
ijpds-4459	139	15	efficient	efficient	ADJ
ijpds-4459	139	16	and	and	CCONJ
ijpds-4459	139	17	targeted	target	VERB
ijpds-4459	139	18	delivery	delivery	NOUN
ijpds-4459	139	19	of	of	ADP
ijpds-4459	139	20	crispr	crispr	ADJ
ijpds-4459	139	21	-	-	PUNCT
ijpds-4459	139	22	cas9	cas9	NOUN
ijpds-4459	139	23	components	component	NOUN
ijpds-4459	139	24	.	.	PUNCT
ijpds-4459	140	1	lipid	lipid	ADJ
ijpds-4459	140	2	nanoparticles	nanoparticle	NOUN
ijpds-4459	140	3	,	,	PUNCT
ijpds-4459	140	4	polymeric	polymeric	ADJ
ijpds-4459	140	5	nanoparticles	nanoparticle	NOUN
ijpds-4459	140	6	,	,	PUNCT
ijpds-4459	140	7	solid	solid	ADJ
ijpds-4459	140	8	-	-	PUNCT
ijpds-4459	140	9	lipid	lipid	NOUN
ijpds-4459	140	10	nanoparticles	nanoparticle	NOUN
ijpds-4459	140	11	,	,	PUNCT
ijpds-4459	140	12	nanostructured	nanostructure	VERB
ijpds-4459	140	13	lipid	lipid	NOUN
ijpds-4459	140	14	carriers	carrier	NOUN
ijpds-4459	140	15	,	,	PUNCT
ijpds-4459	140	16	and	and	CCONJ
ijpds-4459	140	17	niosomes	niosome	NOUN
ijpds-4459	140	18	have	have	AUX
ijpds-4459	140	19	all	all	PRON
ijpds-4459	140	20	shown	show	VERB
ijpds-4459	140	21	great	great	ADJ
ijpds-4459	140	22	potential	potential	NOUN
ijpds-4459	140	23	in	in	ADP
ijpds-4459	140	24	the	the	DET
ijpds-4459	140	25	delivery	delivery	NOUN
ijpds-4459	140	26	of	of	ADP
ijpds-4459	140	27	crispr	crispr	ADJ
ijpds-4459	140	28	compounds	compound	NOUN
ijpds-4459	140	29	to	to	PART
ijpds-4459	140	30	target	target	VERB
ijpds-4459	140	31	cells	cell	NOUN
ijpds-4459	140	32	.	.	PUNCT
ijpds-4459	141	1	additionally	additionally	ADV
ijpds-4459	141	2	,	,	PUNCT
ijpds-4459	141	3	polyamidoamineaptamer	polyamidoamineaptamer	NOUN
ijpds-4459	141	4	modified	modify	VERB
ijpds-4459	141	5	crispr	crispr	ADJ
ijpds-4459	141	6	/	/	SYM
ijpds-4459	141	7	cas9	cas9	NOUN
ijpds-4459	141	8	and	and	CCONJ
ijpds-4459	141	9	sorafenib	sorafenib	NOUN
ijpds-4459	141	10	-	-	PUNCT
ijpds-4459	141	11	loaded	load	VERB
ijpds-4459	141	12	hollow	hollow	ADJ
ijpds-4459	141	13	mesoporous	mesoporous	ADJ
ijpds-4459	141	14	silica	silica	NOUN
ijpds-4459	141	15	nanoparticles	nanoparticle	NOUN
ijpds-4459	141	16	have	have	AUX
ijpds-4459	141	17	exhibited	exhibit	VERB
ijpds-4459	141	18	targeted	target	VERB
ijpds-4459	141	19	delivery	delivery	NOUN
ijpds-4459	141	20	of	of	ADP
ijpds-4459	141	21	crispr	crispr	NOUN
ijpds-4459	141	22	/	/	SYM
ijpds-4459	141	23	cas9	cas9	NOUN
ijpds-4459	141	24	for	for	ADP
ijpds-4459	141	25	precise	precise	ADJ
ijpds-4459	141	26	gene	gene	NOUN
ijpds-4459	141	27	editing	edit	VERB
ijpds-4459	141	28	[	[	X
ijpds-4459	141	29	45	45	NUM
ijpds-4459	141	30	]	]	PUNCT
ijpds-4459	141	31	.	.	PUNCT
ijpds-4459	142	1	2	2	X
ijpds-4459	142	2	.	.	X
ijpds-4459	142	3	liposomes	liposome	NOUN
ijpds-4459	142	4	:	:	PUNCT
ijpds-4459	142	5	liposomes	liposome	NOUN
ijpds-4459	142	6	,	,	PUNCT
ijpds-4459	142	7	characterized	characterize	VERB
ijpds-4459	142	8	by	by	ADP
ijpds-4459	142	9	a	a	DET
ijpds-4459	142	10	lipid	lipid	ADJ
ijpds-4459	142	11	bilayer	bilayer	NOUN
ijpds-4459	142	12	structure	structure	NOUN
ijpds-4459	142	13	,	,	PUNCT
ijpds-4459	142	14	play	play	VERB
ijpds-4459	142	15	a	a	DET
ijpds-4459	142	16	pivotal	pivotal	ADJ
ijpds-4459	142	17	role	role	NOUN
ijpds-4459	142	18	in	in	ADP
ijpds-4459	142	19	genome	genome	NOUN
ijpds-4459	142	20	editing	editing	NOUN
ijpds-4459	142	21	,	,	PUNCT
ijpds-4459	142	22	encapsulating	encapsulate	VERB
ijpds-4459	142	23	various	various	ADJ
ijpds-4459	142	24	agents	agent	NOUN
ijpds-4459	142	25	like	like	ADP
ijpds-4459	142	26	nucleic	nucleic	ADJ
ijpds-4459	142	27	acids	acid	NOUN
ijpds-4459	142	28	and	and	CCONJ
ijpds-4459	142	29	proteins	protein	NOUN
ijpds-4459	142	30	.	.	PUNCT
ijpds-4459	143	1	their	their	PRON
ijpds-4459	143	2	targeted	target	VERB
ijpds-4459	143	3	delivery	delivery	NOUN
ijpds-4459	143	4	,	,	PUNCT
ijpds-4459	143	5	responsiveness	responsiveness	NOUN
ijpds-4459	143	6	to	to	ADP
ijpds-4459	143	7	environmental	environmental	ADJ
ijpds-4459	143	8	cues	cue	NOUN
ijpds-4459	143	9	,	,	PUNCT
ijpds-4459	143	10	and	and	CCONJ
ijpds-4459	143	11	versatility	versatility	NOUN
ijpds-4459	143	12	in	in	ADP
ijpds-4459	143	13	crispr	crispr	ADJ
ijpds-4459	143	14	/	/	SYM
ijpds-4459	143	15	cas9	cas9	NOUN
ijpds-4459	143	16	applications	application	NOUN
ijpds-4459	143	17	make	make	VERB
ijpds-4459	143	18	them	they	PRON
ijpds-4459	143	19	indispensable	indispensable	ADJ
ijpds-4459	143	20	.	.	PUNCT
ijpds-4459	144	1	key	key	ADJ
ijpds-4459	144	2	aspects	aspect	NOUN
ijpds-4459	144	3	in	in	ADP
ijpds-4459	144	4	crispr	crispr	ADJ
ijpds-4459	144	5	delivery	delivery	NOUN
ijpds-4459	144	6	include	include	VERB
ijpds-4459	144	7	:	:	PUNCT
ijpds-4459	144	8			PRON
ijpds-4459	144	9	pegylation	pegylation	NOUN
ijpds-4459	144	10	:	:	PUNCT
ijpds-4459	144	11	enhancing	enhance	VERB
ijpds-4459	144	12	efficiency	efficiency	NOUN
ijpds-4459	144	13	,	,	PUNCT
ijpds-4459	144	14	peg	peg	NOUN
ijpds-4459	144	15	-	-	PUNCT
ijpds-4459	144	16	modified	modify	VERB
ijpds-4459	144	17	liposomes	liposome	NOUN
ijpds-4459	144	18	optimize	optimize	VERB
ijpds-4459	144	19	crispr	crispr	ADJ
ijpds-4459	144	20	delivery	delivery	NOUN
ijpds-4459	144	21	by	by	ADP
ijpds-4459	144	22	improving	improve	VERB
ijpds-4459	144	23	pharmacokinetics	pharmacokinetic	NOUN
ijpds-4459	144	24	and	and	CCONJ
ijpds-4459	144	25	minimizing	minimize	VERB
ijpds-4459	144	26	immune	immune	ADJ
ijpds-4459	144	27	responses	response	NOUN
ijpds-4459	144	28	.	.	PUNCT
ijpds-4459	145	1			X
ijpds-4459	145	2	endosomal	endosomal	ADJ
ijpds-4459	145	3	escape	escape	NOUN
ijpds-4459	145	4	:	:	PUNCT
ijpds-4459	145	5	facilitating	facilitate	VERB
ijpds-4459	145	6	the	the	DET
ijpds-4459	145	7	release	release	NOUN
ijpds-4459	145	8	of	of	ADP
ijpds-4459	145	9	crisprcas9	crisprcas9	NOUN
ijpds-4459	145	10	cargo	cargo	NOUN
ijpds-4459	145	11	into	into	ADP
ijpds-4459	145	12	the	the	DET
ijpds-4459	145	13	cellular	cellular	ADJ
ijpds-4459	145	14	cytoplasm	cytoplasm	NOUN
ijpds-4459	145	15	,	,	PUNCT
ijpds-4459	145	16	liposomes	liposome	NOUN
ijpds-4459	145	17	ensure	ensure	VERB
ijpds-4459	145	18	effective	effective	ADJ
ijpds-4459	145	19	genome	genome	NOUN
ijpds-4459	145	20	editing	editing	NOUN
ijpds-4459	145	21	.	.	PUNCT
ijpds-4459	146	1			X
ijpds-4459	146	2	stimuli	stimuli	VERB
ijpds-4459	146	3	-	-	PUNCT
ijpds-4459	146	4	responsive	responsive	ADJ
ijpds-4459	146	5	design	design	NOUN
ijpds-4459	146	6	:	:	PUNCT
ijpds-4459	146	7	tailored	tailor	VERB
ijpds-4459	146	8	to	to	ADP
ijpds-4459	146	9	environmental	environmental	ADJ
ijpds-4459	146	10	cues	cue	NOUN
ijpds-4459	146	11	,	,	PUNCT
ijpds-4459	146	12	liposomes	liposome	NOUN
ijpds-4459	146	13	provide	provide	VERB
ijpds-4459	146	14	spatial	spatial	ADJ
ijpds-4459	146	15	and	and	CCONJ
ijpds-4459	146	16	temporal	temporal	ADJ
ijpds-4459	146	17	control	control	NOUN
ijpds-4459	146	18	over	over	ADP
ijpds-4459	146	19	crispr	crispr	ADJ
ijpds-4459	146	20	cargo	cargo	NOUN
ijpds-4459	146	21	release	release	NOUN
ijpds-4459	146	22	.	.	PUNCT
ijpds-4459	147	1			NOUN
ijpds-4459	147	2	targeting	target	VERB
ijpds-4459	147	3	strategies	strategy	NOUN
ijpds-4459	147	4	:	:	PUNCT
ijpds-4459	147	5	surface	surface	NOUN
ijpds-4459	147	6	modifications	modification	NOUN
ijpds-4459	147	7	enable	enable	VERB
ijpds-4459	147	8	precise	precise	ADJ
ijpds-4459	147	9	delivery	delivery	NOUN
ijpds-4459	147	10	to	to	ADP
ijpds-4459	147	11	specific	specific	ADJ
ijpds-4459	147	12	cells	cell	NOUN
ijpds-4459	147	13	or	or	CCONJ
ijpds-4459	147	14	tissues	tissue	NOUN
ijpds-4459	147	15	,	,	PUNCT
ijpds-4459	147	16	enhancing	enhance	VERB
ijpds-4459	147	17	crispr	crispr	ADJ
ijpds-4459	147	18	/	/	SYM
ijpds-4459	147	19	cas9	cas9	NOUN
ijpds-4459	147	20	precision	precision	NOUN
ijpds-4459	147	21	.	.	PUNCT
ijpds-4459	148	1			X
ijpds-4459	148	2	light	light	ADJ
ijpds-4459	148	3	-	-	PUNCT
ijpds-4459	148	4	sensitive	sensitive	ADJ
ijpds-4459	148	5	delivery	delivery	NOUN
ijpds-4459	148	6	:	:	PUNCT
ijpds-4459	148	7	innovative	innovative	ADJ
ijpds-4459	148	8	light	light	ADJ
ijpds-4459	148	9	-	-	PUNCT
ijpds-4459	148	10	sensitive	sensitive	ADJ
ijpds-4459	148	11	liposomes	liposome	NOUN
ijpds-4459	148	12	,	,	PUNCT
ijpds-4459	148	13	like	like	ADP
ijpds-4459	148	14	those	those	PRON
ijpds-4459	148	15	loaded	load	VERB
ijpds-4459	148	16	with	with	ADP
ijpds-4459	148	17	a	a	DET
ijpds-4459	148	18	photosensitizer	photosensitizer	NOUN
ijpds-4459	148	19	,	,	PUNCT
ijpds-4459	148	20	offer	offer	VERB
ijpds-4459	148	21	precise	precise	ADJ
ijpds-4459	148	22	spatial	spatial	ADJ
ijpds-4459	148	23	and	and	CCONJ
ijpds-4459	148	24	temporal	temporal	ADJ
ijpds-4459	148	25	control	control	NOUN
ijpds-4459	148	26	in	in	ADP
ijpds-4459	148	27	crispr	crispr	ADJ
ijpds-4459	148	28	/	/	SYM
ijpds-4459	148	29	cas9	cas9	NOUN
ijpds-4459	148	30	gene	gene	NOUN
ijpds-4459	148	31	editing	edit	VERB
ijpds-4459	148	32	.	.	PUNCT
ijpds-4459	149	1	despite	despite	SCONJ
ijpds-4459	149	2	challenges	challenge	NOUN
ijpds-4459	149	3	like	like	ADP
ijpds-4459	149	4	low	low	ADJ
ijpds-4459	149	5	transfection	transfection	NOUN
ijpds-4459	149	6	efficiency	efficiency	NOUN
ijpds-4459	149	7	,	,	PUNCT
ijpds-4459	149	8	the	the	DET
ijpds-4459	149	9	adaptability	adaptability	NOUN
ijpds-4459	149	10	of	of	ADP
ijpds-4459	149	11	liposome	liposome	NOUN
ijpds-4459	149	12	formulations	formulation	NOUN
ijpds-4459	149	13	allows	allow	VERB
ijpds-4459	149	14	customization	customization	NOUN
ijpds-4459	149	15	for	for	ADP
ijpds-4459	149	16	specific	specific	ADJ
ijpds-4459	149	17	crispr	crispr	ADJ
ijpds-4459	149	18	requirements	requirement	NOUN
ijpds-4459	149	19	.	.	PUNCT
ijpds-4459	150	1	noteworthy	noteworthy	ADJ
ijpds-4459	150	2	liposome	liposome	NOUN
ijpds-4459	150	3	types	type	NOUN
ijpds-4459	150	4	include	include	VERB
ijpds-4459	150	5	:	:	PUNCT
ijpds-4459	150	6			PRON
ijpds-4459	150	7	eg	eg	NOUN
ijpds-4459	150	8	-	-	PUNCT
ijpds-4459	150	9	bearing	bear	VERB
ijpds-4459	150	10	liposomes	liposome	NOUN
ijpds-4459	150	11	:	:	PUNCT
ijpds-4459	150	12	tailored	tailor	VERB
ijpds-4459	150	13	with	with	ADP
ijpds-4459	150	14	peg	peg	NOUN
ijpds-4459	150	15	,	,	PUNCT
ijpds-4459	150	16	these	these	DET
ijpds-4459	150	17	liposomes	liposome	NOUN
ijpds-4459	150	18	,	,	PUNCT
ijpds-4459	150	19	like	like	ADP
ijpds-4459	150	20	the	the	DET
ijpds-4459	150	21	ones	one	NOUN
ijpds-4459	150	22	carrying	carry	VERB
ijpds-4459	150	23	crispr	crispr	ADJ
ijpds-4459	150	24	components	component	NOUN
ijpds-4459	150	25	,	,	PUNCT
ijpds-4459	150	26	enhance	enhance	VERB
ijpds-4459	150	27	genome	genome	NOUN
ijpds-4459	150	28	editing	editing	NOUN
ijpds-4459	150	29	efficiency	efficiency	NOUN
ijpds-4459	150	30	by	by	ADP
ijpds-4459	150	31	improving	improve	VERB
ijpds-4459	150	32	pharmacokinetics	pharmacokinetic	NOUN
ijpds-4459	150	33	and	and	CCONJ
ijpds-4459	150	34	minimizing	minimize	VERB
ijpds-4459	150	35	immune	immune	ADJ
ijpds-4459	150	36	responses	response	NOUN
ijpds-4459	150	37	.	.	PUNCT
ijpds-4459	151	1			PRON
ijpds-4459	151	2	charged	charge	VERB
ijpds-4459	151	3	liposomes	liposome	NOUN
ijpds-4459	151	4	:	:	PUNCT
ijpds-4459	151	5	positively	positively	ADV
ijpds-4459	151	6	or	or	CCONJ
ijpds-4459	151	7	negatively	negatively	ADV
ijpds-4459	151	8	charged	charge	VERB
ijpds-4459	151	9	liposomes	liposome	NOUN
ijpds-4459	151	10	,	,	PUNCT
ijpds-4459	151	11	exemplified	exemplify	VERB
ijpds-4459	151	12	by	by	ADP
ijpds-4459	151	13	those	those	PRON
ijpds-4459	151	14	carrying	carry	VERB
ijpds-4459	151	15	crispr	crispr	ADJ
ijpds-4459	151	16	payloads	payload	NOUN
ijpds-4459	151	17	,	,	PUNCT
ijpds-4459	151	18	target	target	VERB
ijpds-4459	151	19	specific	specific	ADJ
ijpds-4459	151	20	cells	cell	NOUN
ijpds-4459	151	21	,	,	PUNCT
ijpds-4459	151	22	contributing	contribute	VERB
ijpds-4459	151	23	to	to	ADP
ijpds-4459	151	24	precise	precise	ADJ
ijpds-4459	151	25	genetic	genetic	ADJ
ijpds-4459	151	26	modifications	modification	NOUN
ijpds-4459	151	27	.	.	PUNCT
ijpds-4459	152	1			X
ijpds-4459	152	2	stimuli	stimuli	VERB
ijpds-4459	152	3	-	-	PUNCT
ijpds-4459	152	4	responsive	responsive	ADJ
ijpds-4459	152	5	liposomes	liposome	NOUN
ijpds-4459	152	6	:	:	PUNCT
ijpds-4459	152	7	engineered	engineer	VERB
ijpds-4459	152	8	to	to	PART
ijpds-4459	152	9	respond	respond	VERB
ijpds-4459	152	10	to	to	ADP
ijpds-4459	152	11	environmental	environmental	ADJ
ijpds-4459	152	12	cues	cue	NOUN
ijpds-4459	152	13	,	,	PUNCT
ijpds-4459	152	14	liposomes	liposome	NOUN
ijpds-4459	152	15	,	,	PUNCT
ijpds-4459	152	16	such	such	ADJ
ijpds-4459	152	17	as	as	ADP
ijpds-4459	152	18	those	those	PRON
ijpds-4459	152	19	used	use	VERB
ijpds-4459	152	20	in	in	ADP
ijpds-4459	152	21	crispr	crispr	ADJ
ijpds-4459	152	22	delivery	delivery	NOUN
ijpds-4459	152	23	,	,	PUNCT
ijpds-4459	152	24	ensure	ensure	VERB
ijpds-4459	152	25	spatial	spatial	ADJ
ijpds-4459	152	26	and	and	CCONJ
ijpds-4459	152	27	temporal	temporal	ADJ
ijpds-4459	152	28	control	control	NOUN
ijpds-4459	152	29	over	over	ADP
ijpds-4459	152	30	cargo	cargo	NOUN
ijpds-4459	152	31	release	release	NOUN
ijpds-4459	152	32	,	,	PUNCT
ijpds-4459	152	33	enhancing	enhance	VERB
ijpds-4459	152	34	gene	gene	NOUN
ijpds-4459	152	35	editing	edit	VERB
ijpds-4459	152	36	precision	precision	NOUN
ijpds-4459	152	37	.	.	PUNCT
ijpds-4459	153	1			X
ijpds-4459	153	2	light	light	ADJ
ijpds-4459	153	3	-	-	PUNCT
ijpds-4459	153	4	sensitive	sensitive	ADJ
ijpds-4459	153	5	liposomes	liposome	NOUN
ijpds-4459	153	6	:	:	PUNCT
ijpds-4459	153	7	innovations	innovation	NOUN
ijpds-4459	153	8	like	like	ADP
ijpds-4459	153	9	lightsensitive	lightsensitive	ADJ
ijpds-4459	153	10	liposomes	liposome	NOUN
ijpds-4459	153	11	loaded	load	VERB
ijpds-4459	153	12	with	with	ADP
ijpds-4459	153	13	crispr	crispr	ADJ
ijpds-4459	153	14	components	component	NOUN
ijpds-4459	153	15	provide	provide	VERB
ijpds-4459	153	16	high	high	ADJ
ijpds-4459	153	17	control	control	NOUN
ijpds-4459	153	18	in	in	ADP
ijpds-4459	153	19	gene	gene	NOUN
ijpds-4459	153	20	editing	editing	NOUN
ijpds-4459	153	21	,	,	PUNCT
ijpds-4459	153	22	allowing	allow	VERB
ijpds-4459	153	23	for	for	ADP
ijpds-4459	153	24	flexibility	flexibility	NOUN
ijpds-4459	153	25	and	and	CCONJ
ijpds-4459	153	26	precision	precision	NOUN
ijpds-4459	153	27	.	.	PUNCT
ijpds-4459	154	1			X
ijpds-4459	154	2	ad	ad	NOUN
ijpds-4459	154	3	liposomes	liposome	NOUN
ijpds-4459	154	4	and	and	CCONJ
ijpds-4459	154	5	cationic	cationic	ADJ
ijpds-4459	154	6	lipids	lipid	NOUN
ijpds-4459	154	7	:	:	PUNCT
ijpds-4459	154	8	liposomes	liposome	NOUN
ijpds-4459	154	9	derived	derive	VERB
ijpds-4459	154	10	from	from	ADP
ijpds-4459	154	11	ad	ad	NOUN
ijpds-4459	154	12	liposomes	liposome	NOUN
ijpds-4459	154	13	,	,	PUNCT
ijpds-4459	154	14	as	as	ADV
ijpds-4459	154	15	well	well	ADV
ijpds-4459	154	16	as	as	ADP
ijpds-4459	154	17	those	those	PRON
ijpds-4459	154	18	using	use	VERB
ijpds-4459	154	19	cationic	cationic	ADJ
ijpds-4459	154	20	lipids	lipid	NOUN
ijpds-4459	154	21	like	like	ADP
ijpds-4459	154	22	dotap	dotap	NOUN
ijpds-4459	154	23	and	and	CCONJ
ijpds-4459	154	24	dlin	dlin	PROPN
ijpds-4459	154	25	-	-	PUNCT
ijpds-4459	154	26	mc3	mc3	PROPN
ijpds-4459	154	27	-	-	PUNCT
ijpds-4459	154	28	dma	dma	PROPN
ijpds-4459	154	29	,	,	PUNCT
ijpds-4459	154	30	showcase	showcase	NOUN
ijpds-4459	154	31	enhanced	enhance	VERB
ijpds-4459	154	32	delivery	delivery	NOUN
ijpds-4459	154	33	efficiency	efficiency	NOUN
ijpds-4459	154	34	in	in	ADP
ijpds-4459	154	35	nucleic	nucleic	ADJ
ijpds-4459	154	36	acid	acid	NOUN
ijpds-4459	154	37	and	and	CCONJ
ijpds-4459	154	38	crispr	crispr	ADJ
ijpds-4459	154	39	/	/	SYM
ijpds-4459	154	40	cas9mediated	cas9mediate	VERB
ijpds-4459	154	41	gene	gene	NOUN
ijpds-4459	154	42	editing	editing	NOUN
ijpds-4459	154	43	.	.	PUNCT
ijpds-4459	155	1	these	these	DET
ijpds-4459	155	2	liposomes	liposome	NOUN
ijpds-4459	155	3	optimize	optimize	VERB
ijpds-4459	155	4	genomeediting	genomeediting	NOUN
ijpds-4459	155	5	efficiency	efficiency	NOUN
ijpds-4459	155	6	by	by	ADP
ijpds-4459	155	7	modulating	modulate	VERB
ijpds-4459	155	8	endocytic	endocytic	ADJ
ijpds-4459	155	9	pathways	pathway	NOUN
ijpds-4459	155	10	.	.	PUNCT
ijpds-4459	156	1	[	[	X
ijpds-4459	156	2	46,47	46,47	NUM
ijpds-4459	156	3	]	]	X
ijpds-4459	156	4	.	.	PUNCT
ijpds-4459	157	1	3	3	X
ijpds-4459	157	2	.	.	X
ijpds-4459	157	3	viral	viral	ADJ
ijpds-4459	157	4	vectors	vector	NOUN
ijpds-4459	157	5	:	:	PUNCT
ijpds-4459	157	6	viral	viral	ADJ
ijpds-4459	157	7	vectors	vector	NOUN
ijpds-4459	157	8	,	,	PUNCT
ijpds-4459	157	9	such	such	ADJ
ijpds-4459	157	10	as	as	ADP
ijpds-4459	157	11	adeno	adeno	NOUN
ijpds-4459	157	12	-	-	PUNCT
ijpds-4459	157	13	associated	associate	VERB
ijpds-4459	157	14	viruses	virus	NOUN
ijpds-4459	157	15	(	(	PUNCT
ijpds-4459	157	16	aavs	aavs	ADV
ijpds-4459	157	17	)	)	PUNCT
ijpds-4459	157	18	and	and	CCONJ
ijpds-4459	157	19	lentiviruses	lentiviruse	NOUN
ijpds-4459	157	20	,	,	PUNCT
ijpds-4459	157	21	have	have	VERB
ijpds-4459	157	22	a	a	DET
ijpds-4459	157	23	well	well	ADV
ijpds-4459	157	24	-	-	PUNCT
ijpds-4459	157	25	established	establish	VERB
ijpds-4459	157	26	history	history	NOUN
ijpds-4459	157	27	in	in	ADP
ijpds-4459	157	28	gene	gene	NOUN
ijpds-4459	157	29	therapy	therapy	NOUN
ijpds-4459	157	30	and	and	CCONJ
ijpds-4459	157	31	are	be	AUX
ijpds-4459	157	32	now	now	ADV
ijpds-4459	157	33	integral	integral	ADJ
ijpds-4459	157	34	to	to	ADP
ijpds-4459	157	35	genome	genome	NOUN
ijpds-4459	157	36	editing	editing	NOUN
ijpds-4459	157	37	.	.	PUNCT
ijpds-4459	158	1	these	these	DET
ijpds-4459	158	2	vectors	vector	NOUN
ijpds-4459	158	3	deliver	deliver	VERB
ijpds-4459	158	4	the	the	DET
ijpds-4459	158	5	crispr	crispr	ADJ
ijpds-4459	158	6	-	-	PUNCT
ijpds-4459	158	7	cas9	cas9	NOUN
ijpds-4459	158	8	system	system	NOUN
ijpds-4459	158	9	to	to	PART
ijpds-4459	158	10	target	target	VERB
ijpds-4459	158	11	cells	cell	NOUN
ijpds-4459	158	12	with	with	ADP
ijpds-4459	158	13	remarkable	remarkable	ADJ
ijpds-4459	158	14	efficiency	efficiency	NOUN
ijpds-4459	158	15	and	and	CCONJ
ijpds-4459	158	16	offer	offer	VERB
ijpds-4459	158	17	the	the	DET
ijpds-4459	158	18	advantage	advantage	NOUN
ijpds-4459	158	19	of	of	ADP
ijpds-4459	158	20	providing	provide	VERB
ijpds-4459	158	21	long	long	ADJ
ijpds-4459	158	22	-	-	PUNCT
ijpds-4459	158	23	term	term	NOUN
ijpds-4459	158	24	expression	expression	NOUN
ijpds-4459	158	25	of	of	ADP
ijpds-4459	158	26	cas9	cas9	NOUN
ijpds-4459	158	27	and	and	CCONJ
ijpds-4459	158	28	grna	grna	NOUN
ijpds-4459	158	29	,	,	PUNCT
ijpds-4459	158	30	making	make	VERB
ijpds-4459	158	31	them	they	PRON
ijpds-4459	158	32	particularly	particularly	ADV
ijpds-4459	158	33	suitable	suitable	ADJ
ijpds-4459	158	34	for	for	ADP
ijpds-4459	158	35	genetic	genetic	ADJ
ijpds-4459	158	36	diseases	disease	NOUN
ijpds-4459	158	37	requiring	require	VERB
ijpds-4459	158	38	sustained	sustained	ADJ
ijpds-4459	158	39	correction	correction	NOUN
ijpds-4459	158	40	[	[	X
ijpds-4459	158	41	42	42	NUM
ijpds-4459	158	42	]	]	PUNCT
ijpds-4459	158	43	.	.	PUNCT
ijpds-4459	159	1	the	the	DET
ijpds-4459	159	2	use	use	NOUN
ijpds-4459	159	3	of	of	ADP
ijpds-4459	159	4	viral	viral	ADJ
ijpds-4459	159	5	vectors	vector	NOUN
ijpds-4459	159	6	in	in	ADP
ijpds-4459	159	7	gene	gene	NOUN
ijpds-4459	159	8	therapy	therapy	NOUN
ijpds-4459	159	9	has	have	AUX
ijpds-4459	159	10	seen	see	VERB
ijpds-4459	159	11	significant	significant	ADJ
ijpds-4459	159	12	progress	progress	NOUN
ijpds-4459	159	13	,	,	PUNCT
ijpds-4459	159	14	with	with	ADP
ijpds-4459	159	15	nearly	nearly	ADV
ijpds-4459	159	16	70	70	NUM
ijpds-4459	159	17	%	%	NOUN
ijpds-4459	159	18	of	of	ADP
ijpds-4459	159	19	clinical	clinical	ADJ
ijpds-4459	159	20	trials	trial	NOUN
ijpds-4459	159	21	utilizing	utilize	VERB
ijpds-4459	159	22	viral	viral	ADJ
ijpds-4459	159	23	vectors	vector	NOUN
ijpds-4459	159	24	,	,	PUNCT
ijpds-4459	159	25	highlighting	highlight	VERB
ijpds-4459	159	26	their	their	PRON
ijpds-4459	159	27	continued	continue	VERB
ijpds-4459	159	28	importance	importance	NOUN
ijpds-4459	159	29	in	in	ADP
ijpds-4459	159	30	the	the	DET
ijpds-4459	159	31	field	field	NOUN
ijpds-4459	159	32	.	.	PUNCT
ijpds-4459	160	1	despite	despite	SCONJ
ijpds-4459	160	2	their	their	PRON
ijpds-4459	160	3	successes	success	NOUN
ijpds-4459	160	4	,	,	PUNCT
ijpds-4459	160	5	challenges	challenge	NOUN
ijpds-4459	160	6	still	still	ADV
ijpds-4459	160	7	limit	limit	VERB
ijpds-4459	160	8	their	their	PRON
ijpds-4459	160	9	full	full	ADJ
ijpds-4459	160	10	potential	potential	NOUN
ijpds-4459	160	11	,	,	PUNCT
ijpds-4459	160	12	and	and	CCONJ
ijpds-4459	160	13	ongoing	ongoing	ADJ
ijpds-4459	160	14	research	research	NOUN
ijpds-4459	160	15	aims	aim	VERB
ijpds-4459	160	16	to	to	PART
ijpds-4459	160	17	address	address	VERB
ijpds-4459	160	18	these	these	DET
ijpds-4459	160	19	limitations	limitation	NOUN
ijpds-4459	160	20	.	.	PUNCT
ijpds-4459	161	1	viral	viral	ADJ
ijpds-4459	161	2	vectors	vector	NOUN
ijpds-4459	161	3	have	have	AUX
ijpds-4459	161	4	been	be	AUX
ijpds-4459	161	5	employed	employ	VERB
ijpds-4459	161	6	for	for	ADP
ijpds-4459	161	7	the	the	DET
ijpds-4459	161	8	treatment	treatment	NOUN
ijpds-4459	161	9	of	of	ADP
ijpds-4459	161	10	various	various	ADJ
ijpds-4459	161	11	diseases	disease	NOUN
ijpds-4459	161	12	,	,	PUNCT
ijpds-4459	161	13	including	include	VERB
ijpds-4459	161	14	metabolic	metabolic	NOUN
ijpds-4459	161	15	,	,	PUNCT
ijpds-4459	161	16	cardiovascular	cardiovascular	ADJ
ijpds-4459	161	17	,	,	PUNCT
ijpds-4459	161	18	muscular	muscular	ADJ
ijpds-4459	161	19	,	,	PUNCT
ijpds-4459	161	20	hematologic	hematologic	NOUN
ijpds-4459	161	21	,	,	PUNCT
ijpds-4459	161	22	ophthalmologic	ophthalmologic	ADJ
ijpds-4459	161	23	,	,	PUNCT
ijpds-4459	161	24	and	and	CCONJ
ijpds-4459	161	25	infectious	infectious	ADJ
ijpds-4459	161	26	diseases	disease	NOUN
ijpds-4459	161	27	,	,	PUNCT
ijpds-4459	161	28	as	as	ADV
ijpds-4459	161	29	well	well	ADV
ijpds-4459	161	30	as	as	ADP
ijpds-4459	161	31	different	different	ADJ
ijpds-4459	161	32	types	type	NOUN
ijpds-4459	161	33	of	of	ADP
ijpds-4459	161	34	cancer	cancer	NOUN
ijpds-4459	161	35	[	[	X
ijpds-4459	161	36	43,44	43,44	X
ijpds-4459	161	37	]	]	X
ijpds-4459	161	38	.	.	PUNCT
ijpds-4459	162	1	for	for	ADP
ijpds-4459	162	2	example	example	NOUN
ijpds-4459	162	3	,	,	PUNCT
ijpds-4459	162	4	aav	aav	NOUN
ijpds-4459	162	5	-	-	PUNCT
ijpds-4459	162	6	based	base	VERB
ijpds-4459	162	7	gene	gene	NOUN
ijpds-4459	162	8	therapy	therapy	NOUN
ijpds-4459	162	9	has	have	AUX
ijpds-4459	162	10	been	be	AUX
ijpds-4459	162	11	used	use	VERB
ijpds-4459	162	12	to	to	PART
ijpds-4459	162	13	treat	treat	VERB
ijpds-4459	162	14	spinal	spinal	ADJ
ijpds-4459	162	15	muscular	muscular	ADJ
ijpds-4459	162	16	atrophy	atrophy	NOUN
ijpds-4459	162	17	,	,	PUNCT
ijpds-4459	162	18	a	a	DET
ijpds-4459	162	19	rare	rare	ADJ
ijpds-4459	162	20	genetic	genetic	ADJ
ijpds-4459	162	21	disease	disease	NOUN
ijpds-4459	162	22	that	that	PRON
ijpds-4459	162	23	causes	cause	VERB
ijpds-4459	162	24	muscle	muscle	NOUN
ijpds-4459	162	25	weakness	weakness	NOUN
ijpds-4459	162	26	and	and	CCONJ
ijpds-4459	162	27	wasting	wasting	NOUN
ijpds-4459	162	28	.	.	PUNCT
ijpds-4459	163	1	in	in	ADP
ijpds-4459	163	2	this	this	DET
ijpds-4459	163	3	case	case	NOUN
ijpds-4459	163	4	,	,	PUNCT
ijpds-4459	163	5	the	the	DET
ijpds-4459	163	6	aav	aav	NOUN
ijpds-4459	163	7	vector	vector	NOUN
ijpds-4459	163	8	was	be	AUX
ijpds-4459	163	9	used	use	VERB
ijpds-4459	163	10	to	to	PART
ijpds-4459	163	11	deliver	deliver	VERB
ijpds-4459	163	12	a	a	DET
ijpds-4459	163	13	functional	functional	ADJ
ijpds-4459	163	14	copy	copy	NOUN
ijpds-4459	163	15	of	of	ADP
ijpds-4459	163	16	the	the	DET
ijpds-4459	163	17	smn1	smn1	PROPN
ijpds-4459	163	18	gene	gene	NOUN
ijpds-4459	163	19	to	to	ADP
ijpds-4459	163	20	motor	motor	NOUN
ijpds-4459	163	21	neurons	neuron	NOUN
ijpds-4459	163	22	,	,	PUNCT
ijpds-4459	163	23	resulting	result	VERB
ijpds-4459	163	24	in	in	ADP
ijpds-4459	163	25	improved	improve	VERB
ijpds-4459	163	26	motor	motor	NOUN
ijpds-4459	163	27	function	function	NOUN
ijpds-4459	163	28	and	and	CCONJ
ijpds-4459	163	29	survival	survival	NOUN
ijpds-4459	163	30	in	in	ADP
ijpds-4459	163	31	patients	patient	NOUN
ijpds-4459	163	32	.	.	PUNCT
ijpds-4459	164	1	another	another	DET
ijpds-4459	164	2	example	example	NOUN
ijpds-4459	164	3	is	be	AUX
ijpds-4459	164	4	the	the	DET
ijpds-4459	164	5	use	use	NOUN
ijpds-4459	164	6	of	of	ADP
ijpds-4459	164	7	lentiviral	lentiviral	ADJ
ijpds-4459	164	8	vectors	vector	NOUN
ijpds-4459	164	9	in	in	ADP
ijpds-4459	164	10	the	the	DET
ijpds-4459	164	11	treatment	treatment	NOUN
ijpds-4459	164	12	of	of	ADP
ijpds-4459	164	13	hiv	hiv	PROPN
ijpds-4459	164	14	/	/	SYM
ijpds-4459	164	15	aids	aids	PROPN
ijpds-4459	164	16	.	.	PUNCT
ijpds-4459	165	1	lentiviral	lentiviral	ADJ
ijpds-4459	165	2	vectors	vector	NOUN
ijpds-4459	165	3	have	have	AUX
ijpds-4459	165	4	been	be	AUX
ijpds-4459	165	5	used	use	VERB
ijpds-4459	165	6	to	to	PART
ijpds-4459	165	7	deliver	deliver	VERB
ijpds-4459	165	8	functional	functional	ADJ
ijpds-4459	165	9	copies	copy	NOUN
ijpds-4459	165	10	of	of	ADP
ijpds-4459	165	11	the	the	DET
ijpds-4459	165	12	ccr5	ccr5	NOUN
ijpds-4459	165	13	gene	gene	NOUN
ijpds-4459	165	14	,	,	PUNCT
ijpds-4459	165	15	which	which	PRON
ijpds-4459	165	16	encodes	encode	VERB
ijpds-4459	165	17	a	a	DET
ijpds-4459	165	18	co	co	NOUN
ijpds-4459	165	19	-	-	NOUN
ijpds-4459	165	20	receptor	receptor	NOUN
ijpds-4459	165	21	for	for	ADP
ijpds-4459	165	22	hiv	hiv	PROPN
ijpds-4459	165	23	,	,	PUNCT
ijpds-4459	165	24	to	to	ADP
ijpds-4459	165	25	cd4	cd4	PROPN
ijpds-4459	165	26	+	+	PROPN
ijpds-4459	165	27	t	t	NOUN
ijpds-4459	165	28	cells	cell	NOUN
ijpds-4459	165	29	.	.	PUNCT
ijpds-4459	166	1	this	this	DET
ijpds-4459	166	2	approach	approach	NOUN
ijpds-4459	166	3	has	have	AUX
ijpds-4459	166	4	been	be	AUX
ijpds-4459	166	5	shown	show	VERB
ijpds-4459	166	6	to	to	PART
ijpds-4459	166	7	protect	protect	VERB
ijpds-4459	166	8	against	against	ADP
ijpds-4459	166	9	hiv	hiv	PROPN
ijpds-4459	166	10	infection	infection	NOUN
ijpds-4459	166	11	in	in	ADP
ijpds-4459	166	12	animal	animal	NOUN
ijpds-4459	166	13	models	model	NOUN
ijpds-4459	166	14	and	and	CCONJ
ijpds-4459	166	15	is	be	AUX
ijpds-4459	166	16	currently	currently	ADV
ijpds-4459	166	17	being	be	AUX
ijpds-4459	166	18	tested	test	VERB
ijpds-4459	166	19	in	in	ADP
ijpds-4459	166	20	bhat	bhat	PROPN
ijpds-4459	166	21	&	&	CCONJ
ijpds-4459	166	22	shanbhag	shanbhag	NOUN
ijpds-4459	166	23	biomaterials	biomaterial	NOUN
ijpds-4459	166	24	:	:	PUNCT
ijpds-4459	166	25	revolutionizing	revolutionize	VERB
ijpds-4459	166	26	cancer	cancer	NOUN
ijpds-4459	166	27	immunotherapy	immunotherapy	NOUN
ijpds-4459	166	28	and	and	CCONJ
ijpds-4459	166	29	genomics	genomics	NOUN
ijpds-4459	166	30	vol	vol	NOUN
ijpds-4459	166	31	3	3	NUM
ijpds-4459	166	32	|	|	NOUN
ijpds-4459	166	33	issue	issue	NOUN
ijpds-4459	166	34	2	2	NUM
ijpds-4459	166	35	|	|	ADV
ijpds-4459	166	36	apr	apr	NOUN
ijpds-4459	166	37	–	–	PUNCT
ijpds-4459	166	38	jun	jun	PROPN
ijpds-4459	166	39	2024	2024	NUM
ijpds-4459	166	40	indian	indian	PROPN
ijpds-4459	166	41	j	j	PROPN
ijpds-4459	166	42	pharm	pharm	PROPN
ijpds-4459	166	43	drug	drug	PROPN
ijpds-4459	166	44	studies	study	NOUN
ijpds-4459	166	45	|	|	ADV
ijpds-4459	166	46	41	41	NUM
ijpds-4459	166	47	clinical	clinical	ADJ
ijpds-4459	166	48	trials	trial	NOUN
ijpds-4459	166	49	[	[	X
ijpds-4459	166	50	48	48	NUM
ijpds-4459	166	51	]	]	PUNCT
ijpds-4459	166	52	.	.	PUNCT
ijpds-4459	167	1	the	the	DET
ijpds-4459	167	2	development	development	NOUN
ijpds-4459	167	3	of	of	ADP
ijpds-4459	167	4	nanoparticle	nanoparticle	NOUN
ijpds-4459	167	5	systems	system	NOUN
ijpds-4459	167	6	to	to	PART
ijpds-4459	167	7	deliver	deliver	VERB
ijpds-4459	167	8	the	the	DET
ijpds-4459	167	9	crispr	crispr	ADJ
ijpds-4459	167	10	-	-	PUNCT
ijpds-4459	167	11	cas9	cas9	NOUN
ijpds-4459	167	12	system	system	NOUN
ijpds-4459	167	13	to	to	PART
ijpds-4459	167	14	target	target	VERB
ijpds-4459	167	15	cells	cell	NOUN
ijpds-4459	167	16	has	have	AUX
ijpds-4459	167	17	overcome	overcome	VERB
ijpds-4459	167	18	obstacles	obstacle	NOUN
ijpds-4459	167	19	such	such	ADJ
ijpds-4459	167	20	as	as	ADP
ijpds-4459	167	21	the	the	DET
ijpds-4459	167	22	large	large	ADJ
ijpds-4459	167	23	molecular	molecular	ADJ
ijpds-4459	167	24	weight	weight	NOUN
ijpds-4459	167	25	of	of	ADP
ijpds-4459	167	26	the	the	DET
ijpds-4459	167	27	cas9	cas9	NOUN
ijpds-4459	167	28	protein	protein	NOUN
ijpds-4459	167	29	and	and	CCONJ
ijpds-4459	167	30	its	its	PRON
ijpds-4459	167	31	low	low	ADJ
ijpds-4459	167	32	stability	stability	NOUN
ijpds-4459	167	33	against	against	ADP
ijpds-4459	167	34	serum	serum	NOUN
ijpds-4459	167	35	enzymes	enzyme	NOUN
ijpds-4459	167	36	and	and	CCONJ
ijpds-4459	167	37	proteins	protein	NOUN
ijpds-4459	167	38	.	.	PUNCT
ijpds-4459	168	1	additionally	additionally	ADV
ijpds-4459	168	2	,	,	PUNCT
ijpds-4459	168	3	the	the	DET
ijpds-4459	168	4	use	use	NOUN
ijpds-4459	168	5	of	of	ADP
ijpds-4459	168	6	viral	viral	ADJ
ijpds-4459	168	7	carrier	carrier	NOUN
ijpds-4459	168	8	systems	system	NOUN
ijpds-4459	168	9	has	have	AUX
ijpds-4459	168	10	been	be	AUX
ijpds-4459	168	11	shown	show	VERB
ijpds-4459	168	12	to	to	PART
ijpds-4459	168	13	provide	provide	VERB
ijpds-4459	168	14	high	high	ADJ
ijpds-4459	168	15	efficiency	efficiency	NOUN
ijpds-4459	168	16	in	in	ADP
ijpds-4459	168	17	genome	genome	NOUN
ijpds-4459	168	18	editing	editing	NOUN
ijpds-4459	168	19	.	.	PUNCT
ijpds-4459	169	1	while	while	SCONJ
ijpds-4459	169	2	viral	viral	ADJ
ijpds-4459	169	3	vectors	vector	NOUN
ijpds-4459	169	4	have	have	AUX
ijpds-4459	169	5	demonstrated	demonstrate	VERB
ijpds-4459	169	6	significant	significant	ADJ
ijpds-4459	169	7	promise	promise	NOUN
ijpds-4459	169	8	,	,	PUNCT
ijpds-4459	169	9	ongoing	ongoing	ADJ
ijpds-4459	169	10	research	research	NOUN
ijpds-4459	169	11	and	and	CCONJ
ijpds-4459	169	12	development	development	NOUN
ijpds-4459	169	13	are	be	AUX
ijpds-4459	169	14	focused	focus	VERB
ijpds-4459	169	15	on	on	ADP
ijpds-4459	169	16	addressing	address	VERB
ijpds-4459	169	17	challenges	challenge	NOUN
ijpds-4459	169	18	and	and	CCONJ
ijpds-4459	169	19	further	far	ADV
ijpds-4459	169	20	improving	improve	VERB
ijpds-4459	169	21	their	their	PRON
ijpds-4459	169	22	applicability	applicability	NOUN
ijpds-4459	169	23	.	.	PUNCT
ijpds-4459	170	1	the	the	DET
ijpds-4459	170	2	field	field	NOUN
ijpds-4459	170	3	of	of	ADP
ijpds-4459	170	4	gene	gene	NOUN
ijpds-4459	170	5	therapy	therapy	NOUN
ijpds-4459	170	6	continues	continue	VERB
ijpds-4459	170	7	to	to	PART
ijpds-4459	170	8	see	see	VERB
ijpds-4459	170	9	innovative	innovative	ADJ
ijpds-4459	170	10	modifications	modification	NOUN
ijpds-4459	170	11	and	and	CCONJ
ijpds-4459	170	12	support	support	NOUN
ijpds-4459	170	13	from	from	ADP
ijpds-4459	170	14	the	the	DET
ijpds-4459	170	15	pharmaceutical	pharmaceutical	ADJ
ijpds-4459	170	16	and	and	CCONJ
ijpds-4459	170	17	biotech	biotech	NOUN
ijpds-4459	170	18	industries	industry	NOUN
ijpds-4459	170	19	,	,	PUNCT
ijpds-4459	170	20	indicating	indicate	VERB
ijpds-4459	170	21	a	a	DET
ijpds-4459	170	22	continued	continue	VERB
ijpds-4459	170	23	commitment	commitment	NOUN
ijpds-4459	170	24	to	to	ADP
ijpds-4459	170	25	advancing	advance	VERB
ijpds-4459	170	26	viral	viral	ADJ
ijpds-4459	170	27	vectorbased	vectorbase	VERB
ijpds-4459	170	28	therapy	therapy	NOUN
ijpds-4459	170	29	.	.	PUNCT
ijpds-4459	171	1	therefore	therefore	ADV
ijpds-4459	171	2	,	,	PUNCT
ijpds-4459	171	3	viral	viral	ADJ
ijpds-4459	171	4	vectors	vector	NOUN
ijpds-4459	171	5	,	,	PUNCT
ijpds-4459	171	6	particularly	particularly	ADV
ijpds-4459	171	7	aavs	aavs	VERB
ijpds-4459	171	8	and	and	CCONJ
ijpds-4459	171	9	lentiviruses	lentiviruse	NOUN
ijpds-4459	171	10	,	,	PUNCT
ijpds-4459	171	11	remain	remain	VERB
ijpds-4459	171	12	crucial	crucial	ADJ
ijpds-4459	171	13	tools	tool	NOUN
ijpds-4459	171	14	in	in	ADP
ijpds-4459	171	15	the	the	DET
ijpds-4459	171	16	landscape	landscape	NOUN
ijpds-4459	171	17	of	of	ADP
ijpds-4459	171	18	gene	gene	NOUN
ijpds-4459	171	19	therapy	therapy	NOUN
ijpds-4459	171	20	and	and	CCONJ
ijpds-4459	171	21	genome	genome	NOUN
ijpds-4459	171	22	editing	editing	NOUN
ijpds-4459	171	23	,	,	PUNCT
ijpds-4459	171	24	with	with	ADP
ijpds-4459	171	25	ongoing	ongoing	ADJ
ijpds-4459	171	26	efforts	effort	NOUN
ijpds-4459	171	27	to	to	PART
ijpds-4459	171	28	enhance	enhance	VERB
ijpds-4459	171	29	their	their	PRON
ijpds-4459	171	30	efficacy	efficacy	NOUN
ijpds-4459	171	31	and	and	CCONJ
ijpds-4459	171	32	safety	safety	NOUN
ijpds-4459	171	33	for	for	ADP
ijpds-4459	171	34	clinical	clinical	ADJ
ijpds-4459	171	35	applications	application	NOUN
ijpds-4459	171	36	[	[	X
ijpds-4459	171	37	46	46	NUM
ijpds-4459	171	38	-	-	SYM
ijpds-4459	171	39	48	48	NUM
ijpds-4459	171	40	]	]	PUNCT
ijpds-4459	171	41	.	.	PUNCT
ijpds-4459	172	1	4	4	X
ijpds-4459	172	2	.	.	X
ijpds-4459	172	3	gene	gene	NOUN
ijpds-4459	172	4	editing	edit	VERB
ijpds-4459	172	5	in	in	ADP
ijpds-4459	172	6	stem	stem	NOUN
ijpds-4459	172	7	cells	cell	NOUN
ijpds-4459	172	8	:	:	PUNCT
ijpds-4459	172	9	stem	stem	NOUN
ijpds-4459	172	10	cells	cell	NOUN
ijpds-4459	172	11	hold	hold	VERB
ijpds-4459	172	12	immense	immense	ADJ
ijpds-4459	172	13	potential	potential	NOUN
ijpds-4459	172	14	for	for	ADP
ijpds-4459	172	15	regenerative	regenerative	ADJ
ijpds-4459	172	16	medicine	medicine	NOUN
ijpds-4459	172	17	and	and	CCONJ
ijpds-4459	172	18	cell	cell	NOUN
ijpds-4459	172	19	-	-	PUNCT
ijpds-4459	172	20	based	base	VERB
ijpds-4459	172	21	therapies	therapy	NOUN
ijpds-4459	172	22	stem	stem	NOUN
ijpds-4459	172	23	cells	cell	NOUN
ijpds-4459	172	24	possess	possess	VERB
ijpds-4459	172	25	the	the	DET
ijpds-4459	172	26	unique	unique	ADJ
ijpds-4459	172	27	ability	ability	NOUN
ijpds-4459	172	28	to	to	PART
ijpds-4459	172	29	self	self	NOUN
ijpds-4459	172	30	-	-	PUNCT
ijpds-4459	172	31	renew	renew	VERB
ijpds-4459	172	32	and	and	CCONJ
ijpds-4459	172	33	differentiate	differentiate	VERB
ijpds-4459	172	34	into	into	ADP
ijpds-4459	172	35	various	various	ADJ
ijpds-4459	172	36	cell	cell	NOUN
ijpds-4459	172	37	types	type	NOUN
ijpds-4459	172	38	,	,	PUNCT
ijpds-4459	172	39	making	make	VERB
ijpds-4459	172	40	them	they	PRON
ijpds-4459	172	41	promising	promise	VERB
ijpds-4459	172	42	candidates	candidate	NOUN
ijpds-4459	172	43	for	for	ADP
ijpds-4459	172	44	regenerative	regenerative	ADJ
ijpds-4459	172	45	medicine	medicine	NOUN
ijpds-4459	172	46	and	and	CCONJ
ijpds-4459	172	47	cell	cell	NOUN
ijpds-4459	172	48	-	-	PUNCT
ijpds-4459	172	49	based	base	VERB
ijpds-4459	172	50	therapies	therapy	NOUN
ijpds-4459	172	51	[	[	X
ijpds-4459	172	52	49	49	NUM
ijpds-4459	172	53	]	]	PUNCT
ijpds-4459	172	54	.	.	PUNCT
ijpds-4459	173	1	precisely	precisely	ADV
ijpds-4459	173	2	modifying	modify	VERB
ijpds-4459	173	3	their	their	PRON
ijpds-4459	173	4	genes	gene	NOUN
ijpds-4459	173	5	via	via	ADP
ijpds-4459	173	6	crispr	crispr	ADJ
ijpds-4459	173	7	-	-	PUNCT
ijpds-4459	173	8	cas9	cas9	NOUN
ijpds-4459	173	9	unlocks	unlock	VERB
ijpds-4459	173	10	their	their	PRON
ijpds-4459	173	11	full	full	ADJ
ijpds-4459	173	12	therapeutic	therapeutic	ADJ
ijpds-4459	173	13	potential	potential	NOUN
ijpds-4459	173	14	,	,	PUNCT
ijpds-4459	173	15	and	and	CCONJ
ijpds-4459	173	16	biomaterials	biomaterial	NOUN
ijpds-4459	173	17	play	play	VERB
ijpds-4459	173	18	a	a	DET
ijpds-4459	173	19	crucial	crucial	ADJ
ijpds-4459	173	20	role	role	NOUN
ijpds-4459	173	21	in	in	ADP
ijpds-4459	173	22	achieving	achieve	VERB
ijpds-4459	173	23	this	this	PRON
ijpds-4459	173	24	effectively	effectively	ADV
ijpds-4459	173	25	.	.	PUNCT
ijpds-4459	174	1	let	let	VERB
ijpds-4459	174	2	's	us	PRON
ijpds-4459	174	3	dive	dive	VERB
ijpds-4459	174	4	deeper	deeply	ADV
ijpds-4459	174	5	into	into	ADP
ijpds-4459	174	6	recent	recent	ADJ
ijpds-4459	174	7	developmental	developmental	ADJ
ijpds-4459	174	8	examples	example	NOUN
ijpds-4459	174	9	across	across	ADP
ijpds-4459	174	10	different	different	ADJ
ijpds-4459	174	11	delivery	delivery	NOUN
ijpds-4459	174	12	strategies	strategy	NOUN
ijpds-4459	174	13	:	:	PUNCT
ijpds-4459	174	14	a.	a.	NOUN
ijpds-4459	174	15	transfection	transfection	NOUN
ijpds-4459	174	16	reagents	reagent	NOUN
ijpds-4459	174	17	:	:	PUNCT
ijpds-4459	175	1	lipid	lipid	ADJ
ijpds-4459	175	2	nanoparticles	nanoparticle	NOUN
ijpds-4459	175	3	(	(	PUNCT
ijpds-4459	175	4	lnps	lnps	PROPN
ijpds-4459	175	5	):	):	PUNCT
ijpds-4459	175	6	recent	recent	ADJ
ijpds-4459	175	7	advances	advance	NOUN
ijpds-4459	175	8	involve	involve	VERB
ijpds-4459	175	9	lnps	lnps	PROPN
ijpds-4459	175	10	modified	modify	VERB
ijpds-4459	175	11	with	with	ADP
ijpds-4459	175	12	cell	cell	NOUN
ijpds-4459	175	13	-	-	PUNCT
ijpds-4459	175	14	specific	specific	ADJ
ijpds-4459	175	15	targeting	targeting	NOUN
ijpds-4459	175	16	ligands	ligand	NOUN
ijpds-4459	175	17	.	.	PUNCT
ijpds-4459	176	1	for	for	ADP
ijpds-4459	176	2	instance	instance	NOUN
ijpds-4459	176	3	,	,	PUNCT
ijpds-4459	176	4	researchers	researcher	NOUN
ijpds-4459	176	5	conjugated	conjugate	VERB
ijpds-4459	176	6	folate	folate	VERB
ijpds-4459	176	7	ligands	ligand	NOUN
ijpds-4459	176	8	to	to	PART
ijpds-4459	176	9	lnps	lnps	VERB
ijpds-4459	176	10	for	for	ADP
ijpds-4459	176	11	targeted	target	VERB
ijpds-4459	176	12	delivery	delivery	NOUN
ijpds-4459	176	13	to	to	PART
ijpds-4459	176	14	pluripotent	pluripotent	VERB
ijpds-4459	176	15	stem	stem	NOUN
ijpds-4459	176	16	cells	cell	NOUN
ijpds-4459	176	17	expressing	express	VERB
ijpds-4459	176	18	folate	folate	NOUN
ijpds-4459	176	19	receptors	receptor	NOUN
ijpds-4459	176	20	.	.	PUNCT
ijpds-4459	177	1	this	this	PRON
ijpds-4459	177	2	led	lead	VERB
ijpds-4459	177	3	to	to	ADP
ijpds-4459	177	4	efficient	efficient	ADJ
ijpds-4459	177	5	gene	gene	NOUN
ijpds-4459	177	6	editing	edit	VERB
ijpds-4459	177	7	with	with	ADP
ijpds-4459	177	8	minimal	minimal	ADJ
ijpds-4459	177	9	off	off	ADP
ijpds-4459	177	10	-	-	PUNCT
ijpds-4459	177	11	target	target	NOUN
ijpds-4459	177	12	effects	effect	NOUN
ijpds-4459	177	13	[	[	X
ijpds-4459	177	14	48	48	NUM
ijpds-4459	177	15	]	]	PUNCT
ijpds-4459	177	16	.	.	PUNCT
ijpds-4459	178	1	b.	b.	PROPN
ijpds-4459	178	2	polymer	polymer	NOUN
ijpds-4459	178	3	-	-	PUNCT
ijpds-4459	178	4	peptide	peptide	NOUN
ijpds-4459	178	5	hybrids	hybrid	NOUN
ijpds-4459	178	6	:	:	PUNCT
ijpds-4459	178	7	novel	novel	ADJ
ijpds-4459	178	8	synthetic	synthetic	ADJ
ijpds-4459	178	9	polymers	polymer	NOUN
ijpds-4459	178	10	with	with	ADP
ijpds-4459	178	11	peptide	peptide	ADJ
ijpds-4459	178	12	conjugation	conjugation	NOUN
ijpds-4459	178	13	offer	offer	NOUN
ijpds-4459	178	14	enhanced	enhance	VERB
ijpds-4459	178	15	cellular	cellular	ADJ
ijpds-4459	178	16	uptake	uptake	NOUN
ijpds-4459	178	17	and	and	CCONJ
ijpds-4459	178	18	endosomal	endosomal	ADJ
ijpds-4459	178	19	escape	escape	NOUN
ijpds-4459	178	20	.	.	PUNCT
ijpds-4459	179	1	a	a	DET
ijpds-4459	179	2	recent	recent	ADJ
ijpds-4459	179	3	study	study	NOUN
ijpds-4459	179	4	employed	employ	VERB
ijpds-4459	179	5	chitosanbased	chitosanbase	VERB
ijpds-4459	179	6	polymers	polymer	NOUN
ijpds-4459	179	7	conjugated	conjugate	VERB
ijpds-4459	179	8	with	with	ADP
ijpds-4459	179	9	cationic	cationic	ADJ
ijpds-4459	179	10	peptides	peptide	NOUN
ijpds-4459	179	11	for	for	ADP
ijpds-4459	179	12	crispr	crispr	ADJ
ijpds-4459	179	13	-	-	PUNCT
ijpds-4459	179	14	cas9	cas9	NOUN
ijpds-4459	179	15	delivery	delivery	NOUN
ijpds-4459	179	16	to	to	ADP
ijpds-4459	179	17	mesenchymal	mesenchymal	ADJ
ijpds-4459	179	18	stem	stem	NOUN
ijpds-4459	179	19	cells	cell	NOUN
ijpds-4459	179	20	,	,	PUNCT
ijpds-4459	179	21	achieving	achieve	VERB
ijpds-4459	179	22	high	high	ADJ
ijpds-4459	179	23	editing	edit	VERB
ijpds-4459	179	24	efficiency	efficiency	NOUN
ijpds-4459	179	25	with	with	ADP
ijpds-4459	179	26	improved	improved	ADJ
ijpds-4459	179	27	biocompatibility	biocompatibility	NOUN
ijpds-4459	180	1	[	[	X
ijpds-4459	180	2	48,49	48,49	X
ijpds-4459	180	3	]	]	PUNCT
ijpds-4459	180	4	.	.	PUNCT
ijpds-4459	181	1	c.	c.	PROPN
ijpds-4459	181	2	electroporation	electroporation	NOUN
ijpds-4459	181	3	platforms	platform	NOUN
ijpds-4459	181	4	:	:	PUNCT
ijpds-4459	181	5			X
ijpds-4459	181	6	microfluidic	microfluidic	ADJ
ijpds-4459	181	7	chips	chip	NOUN
ijpds-4459	181	8	:	:	PUNCT
ijpds-4459	181	9	researchers	researcher	NOUN
ijpds-4459	181	10	are	be	AUX
ijpds-4459	181	11	now	now	ADV
ijpds-4459	181	12	integrating	integrate	VERB
ijpds-4459	181	13	microfluidic	microfluidic	ADJ
ijpds-4459	181	14	chips	chip	NOUN
ijpds-4459	181	15	with	with	ADP
ijpds-4459	181	16	temperature	temperature	NOUN
ijpds-4459	181	17	control	control	NOUN
ijpds-4459	181	18	to	to	PART
ijpds-4459	181	19	enhance	enhance	VERB
ijpds-4459	181	20	cell	cell	NOUN
ijpds-4459	181	21	viability	viability	NOUN
ijpds-4459	181	22	during	during	ADP
ijpds-4459	181	23	electroporation	electroporation	NOUN
ijpds-4459	181	24	.	.	PUNCT
ijpds-4459	182	1	a	a	DET
ijpds-4459	182	2	recent	recent	ADJ
ijpds-4459	182	3	study	study	NOUN
ijpds-4459	182	4	used	use	VERB
ijpds-4459	182	5	a	a	DET
ijpds-4459	182	6	temperature	temperature	NOUN
ijpds-4459	182	7	-	-	PUNCT
ijpds-4459	182	8	controlled	control	VERB
ijpds-4459	182	9	microfluidic	microfluidic	ADJ
ijpds-4459	182	10	chip	chip	NOUN
ijpds-4459	182	11	for	for	ADP
ijpds-4459	182	12	crisprcas9	crisprcas9	NOUN
ijpds-4459	182	13	delivery	delivery	NOUN
ijpds-4459	182	14	to	to	ADP
ijpds-4459	182	15	neural	neural	ADJ
ijpds-4459	182	16	stem	stem	NOUN
ijpds-4459	182	17	cells	cell	NOUN
ijpds-4459	182	18	,	,	PUNCT
ijpds-4459	182	19	demonstrating	demonstrate	VERB
ijpds-4459	182	20	improved	improve	VERB
ijpds-4459	182	21	cell	cell	NOUN
ijpds-4459	182	22	survival	survival	NOUN
ijpds-4459	182	23	and	and	CCONJ
ijpds-4459	182	24	editing	edit	VERB
ijpds-4459	182	25	efficiency	efficiency	NOUN
ijpds-4459	182	26	compared	compare	VERB
ijpds-4459	182	27	to	to	ADP
ijpds-4459	182	28	conventional	conventional	ADJ
ijpds-4459	182	29	methods	method	NOUN
ijpds-4459	182	30	[	[	X
ijpds-4459	182	31	50	50	NUM
ijpds-4459	182	32	]	]	PUNCT
ijpds-4459	182	33	.	.	PUNCT
ijpds-4459	183	1			X
ijpds-4459	183	2	conductive	conductive	ADJ
ijpds-4459	183	3	hydrogels	hydrogel	NOUN
ijpds-4459	183	4	:	:	PUNCT
ijpds-4459	183	5	development	development	NOUN
ijpds-4459	183	6	of	of	ADP
ijpds-4459	183	7	hydrogels	hydrogel	NOUN
ijpds-4459	183	8	with	with	ADP
ijpds-4459	183	9	specific	specific	ADJ
ijpds-4459	183	10	electrical	electrical	ADJ
ijpds-4459	183	11	properties	property	NOUN
ijpds-4459	183	12	allows	allow	VERB
ijpds-4459	183	13	for	for	ADP
ijpds-4459	183	14	localized	localize	VERB
ijpds-4459	183	15	,	,	PUNCT
ijpds-4459	183	16	tissuespecific	tissuespecific	NOUN
ijpds-4459	183	17	crispr	crispr	ADJ
ijpds-4459	183	18	-	-	PUNCT
ijpds-4459	183	19	cas9	cas9	NOUN
ijpds-4459	183	20	delivery	delivery	NOUN
ijpds-4459	183	21	.	.	PUNCT
ijpds-4459	184	1	scientists	scientist	NOUN
ijpds-4459	184	2	developed	develop	VERB
ijpds-4459	184	3	a	a	DET
ijpds-4459	184	4	conductive	conductive	ADJ
ijpds-4459	184	5	hydrogel	hydrogel	NOUN
ijpds-4459	184	6	scaffold	scaffold	NOUN
ijpds-4459	184	7	for	for	ADP
ijpds-4459	184	8	in	in	ADP
ijpds-4459	184	9	vivo	vivo	ADJ
ijpds-4459	184	10	delivery	delivery	NOUN
ijpds-4459	184	11	to	to	ADP
ijpds-4459	184	12	cardiac	cardiac	ADJ
ijpds-4459	184	13	stem	stem	NOUN
ijpds-4459	184	14	cells	cell	NOUN
ijpds-4459	184	15	residing	reside	VERB
ijpds-4459	184	16	within	within	ADP
ijpds-4459	184	17	heart	heart	NOUN
ijpds-4459	184	18	tissue	tissue	NOUN
ijpds-4459	184	19	.	.	PUNCT
ijpds-4459	185	1	this	this	DET
ijpds-4459	185	2	approach	approach	NOUN
ijpds-4459	185	3	facilitated	facilitate	VERB
ijpds-4459	185	4	targeted	target	VERB
ijpds-4459	185	5	gene	gene	NOUN
ijpds-4459	185	6	editing	edit	VERB
ijpds-4459	185	7	with	with	ADP
ijpds-4459	185	8	minimal	minimal	ADJ
ijpds-4459	185	9	impact	impact	NOUN
ijpds-4459	185	10	on	on	ADP
ijpds-4459	185	11	surrounding	surround	VERB
ijpds-4459	185	12	tissues	tissue	NOUN
ijpds-4459	186	1	[	[	X
ijpds-4459	186	2	49,50	49,50	X
ijpds-4459	186	3	]	]	PUNCT
ijpds-4459	186	4	.	.	PUNCT
ijpds-4459	187	1	d.	d.	PROPN
ijpds-4459	187	2	viral	viral	ADJ
ijpds-4459	187	3	vectors	vector	NOUN
ijpds-4459	187	4	:	:	PUNCT
ijpds-4459	187	5			PRON
ijpds-4459	187	6	engineered	engineer	VERB
ijpds-4459	187	7	aav	aav	NOUN
ijpds-4459	187	8	vectors	vector	NOUN
ijpds-4459	187	9	:	:	PUNCT
ijpds-4459	187	10	adeno	adeno	NOUN
ijpds-4459	187	11	-	-	PUNCT
ijpds-4459	187	12	associated	associate	VERB
ijpds-4459	187	13	viral	viral	ADJ
ijpds-4459	187	14	(	(	PUNCT
ijpds-4459	187	15	aav	aav	NOUN
ijpds-4459	187	16	)	)	PUNCT
ijpds-4459	187	17	vectors	vector	NOUN
ijpds-4459	187	18	are	be	AUX
ijpds-4459	187	19	gaining	gain	VERB
ijpds-4459	187	20	popularity	popularity	NOUN
ijpds-4459	187	21	due	due	ADP
ijpds-4459	187	22	to	to	ADP
ijpds-4459	187	23	their	their	PRON
ijpds-4459	187	24	safety	safety	NOUN
ijpds-4459	187	25	and	and	CCONJ
ijpds-4459	187	26	low	low	ADJ
ijpds-4459	187	27	immunogenicity	immunogenicity	NOUN
ijpds-4459	187	28	.	.	PUNCT
ijpds-4459	188	1	recent	recent	ADJ
ijpds-4459	188	2	efforts	effort	NOUN
ijpds-4459	188	3	focus	focus	VERB
ijpds-4459	188	4	on	on	ADP
ijpds-4459	188	5	enhancing	enhance	VERB
ijpds-4459	188	6	their	their	PRON
ijpds-4459	188	7	targeting	targeting	NOUN
ijpds-4459	188	8	capabilities	capability	NOUN
ijpds-4459	188	9	.	.	PUNCT
ijpds-4459	189	1	researchers	researcher	NOUN
ijpds-4459	189	2	engineered	engineer	VERB
ijpds-4459	189	3	aav	aav	NOUN
ijpds-4459	189	4	vectors	vector	NOUN
ijpds-4459	189	5	with	with	ADP
ijpds-4459	189	6	stem	stem	NOUN
ijpds-4459	189	7	cell	cell	NOUN
ijpds-4459	189	8	-	-	PUNCT
ijpds-4459	189	9	specific	specific	ADJ
ijpds-4459	189	10	promoters	promoter	NOUN
ijpds-4459	189	11	,	,	PUNCT
ijpds-4459	189	12	achieving	achieve	VERB
ijpds-4459	189	13	efficient	efficient	ADJ
ijpds-4459	189	14	and	and	CCONJ
ijpds-4459	189	15	selective	selective	ADJ
ijpds-4459	189	16	gene	gene	NOUN
ijpds-4459	189	17	editing	edit	VERB
ijpds-4459	189	18	in	in	ADP
ijpds-4459	189	19	human	human	ADJ
ijpds-4459	189	20	embryonic	embryonic	ADJ
ijpds-4459	189	21	stem	stem	NOUN
ijpds-4459	189	22	cells	cell	NOUN
ijpds-4459	189	23	without	without	ADP
ijpds-4459	189	24	harming	harm	VERB
ijpds-4459	189	25	neighboring	neighboring	NOUN
ijpds-4459	189	26	cell	cell	NOUN
ijpds-4459	189	27	types	type	NOUN
ijpds-4459	189	28	[	[	X
ijpds-4459	189	29	51	51	NUM
ijpds-4459	189	30	]	]	PUNCT
ijpds-4459	189	31	.	.	PUNCT
ijpds-4459	190	1			X
ijpds-4459	190	2	hybrid	hybrid	ADJ
ijpds-4459	190	3	viral	viral	ADJ
ijpds-4459	190	4	vectors	vector	NOUN
ijpds-4459	190	5	:	:	PUNCT
ijpds-4459	190	6	combining	combine	VERB
ijpds-4459	190	7	different	different	ADJ
ijpds-4459	190	8	viral	viral	ADJ
ijpds-4459	190	9	vectors	vector	NOUN
ijpds-4459	190	10	leverages	leverage	VERB
ijpds-4459	190	11	their	their	PRON
ijpds-4459	190	12	unique	unique	ADJ
ijpds-4459	190	13	strengths	strength	NOUN
ijpds-4459	190	14	.	.	PUNCT
ijpds-4459	191	1	a	a	DET
ijpds-4459	191	2	recent	recent	ADJ
ijpds-4459	191	3	study	study	NOUN
ijpds-4459	191	4	used	use	VERB
ijpds-4459	191	5	a	a	DET
ijpds-4459	191	6	hybrid	hybrid	ADJ
ijpds-4459	191	7	vector	vector	NOUN
ijpds-4459	191	8	combining	combine	VERB
ijpds-4459	191	9	aav	aav	NOUN
ijpds-4459	191	10	and	and	CCONJ
ijpds-4459	191	11	lentiviral	lentiviral	ADJ
ijpds-4459	191	12	vectors	vector	NOUN
ijpds-4459	191	13	,	,	PUNCT
ijpds-4459	191	14	achieving	achieve	VERB
ijpds-4459	191	15	sustained	sustained	ADJ
ijpds-4459	191	16	and	and	CCONJ
ijpds-4459	191	17	efficient	efficient	ADJ
ijpds-4459	191	18	gene	gene	NOUN
ijpds-4459	191	19	editing	edit	VERB
ijpds-4459	191	20	in	in	ADP
ijpds-4459	191	21	hematopoietic	hematopoietic	ADJ
ijpds-4459	191	22	stem	stem	NOUN
ijpds-4459	191	23	cells	cell	NOUN
ijpds-4459	191	24	with	with	ADP
ijpds-4459	191	25	minimal	minimal	ADJ
ijpds-4459	191	26	insertional	insertional	ADJ
ijpds-4459	191	27	mutagenesis	mutagenesis	NOUN
ijpds-4459	191	28	[	[	X
ijpds-4459	191	29	52	52	NUM
ijpds-4459	191	30	]	]	PUNCT
ijpds-4459	191	31	.	.	PUNCT
ijpds-4459	192	1	e.	e.	PROPN
ijpds-4459	192	2	in	in	ADP
ijpds-4459	192	3	-	-	PUNCT
ijpds-4459	192	4	vivo	vivo	NOUN
ijpds-4459	192	5	genome	genome	NOUN
ijpds-4459	192	6	editing	editing	NOUN
ijpds-4459	192	7	:	:	PUNCT
ijpds-4459	192	8	in	in	ADP
ijpds-4459	192	9	vivo	vivo	ADJ
ijpds-4459	192	10	genome	genome	NOUN
ijpds-4459	192	11	editing	editing	NOUN
ijpds-4459	192	12	holds	hold	VERB
ijpds-4459	192	13	immense	immense	ADJ
ijpds-4459	192	14	promise	promise	NOUN
ijpds-4459	192	15	for	for	ADP
ijpds-4459	192	16	treating	treat	VERB
ijpds-4459	192	17	genetic	genetic	ADJ
ijpds-4459	192	18	disorders	disorder	NOUN
ijpds-4459	192	19	directly	directly	ADV
ijpds-4459	192	20	within	within	ADP
ijpds-4459	192	21	the	the	DET
ijpds-4459	192	22	patient	patient	NOUN
ijpds-4459	192	23	's	's	PART
ijpds-4459	192	24	body	body	NOUN
ijpds-4459	192	25	[	[	X
ijpds-4459	192	26	40	40	NUM
ijpds-4459	192	27	]	]	PUNCT
ijpds-4459	192	28	.	.	PUNCT
ijpds-4459	193	1	however	however	ADV
ijpds-4459	193	2	,	,	PUNCT
ijpds-4459	193	3	delivering	deliver	VERB
ijpds-4459	193	4	crispr	crispr	ADJ
ijpds-4459	193	5	-	-	PUNCT
ijpds-4459	193	6	cas9	cas9	NOUN
ijpds-4459	193	7	components	component	NOUN
ijpds-4459	193	8	to	to	PART
ijpds-4459	193	9	target	target	VERB
ijpds-4459	193	10	tissues	tissue	NOUN
ijpds-4459	193	11	or	or	CCONJ
ijpds-4459	193	12	organs	organ	NOUN
ijpds-4459	193	13	in	in	ADP
ijpds-4459	193	14	a	a	DET
ijpds-4459	193	15	specific	specific	ADJ
ijpds-4459	193	16	and	and	CCONJ
ijpds-4459	193	17	efficient	efficient	ADJ
ijpds-4459	193	18	manner	manner	NOUN
ijpds-4459	193	19	remains	remain	VERB
ijpds-4459	193	20	a	a	DET
ijpds-4459	193	21	significant	significant	ADJ
ijpds-4459	193	22	challenge	challenge	NOUN
ijpds-4459	193	23	.	.	PUNCT
ijpds-4459	194	1	innovative	innovative	ADJ
ijpds-4459	194	2	strategies	strategy	NOUN
ijpds-4459	194	3	are	be	AUX
ijpds-4459	194	4	being	be	AUX
ijpds-4459	194	5	developed	develop	VERB
ijpds-4459	194	6	to	to	PART
ijpds-4459	194	7	overcome	overcome	VERB
ijpds-4459	194	8	these	these	DET
ijpds-4459	194	9	challenges	challenge	NOUN
ijpds-4459	194	10	and	and	CCONJ
ijpds-4459	194	11	propel	propel	VERB
ijpds-4459	194	12	the	the	DET
ijpds-4459	194	13	field	field	NOUN
ijpds-4459	194	14	forward	forward	ADV
ijpds-4459	194	15	.	.	PUNCT
ijpds-4459	195	1	f.	f.	PROPN
ijpds-4459	195	2	targeted	target	VERB
ijpds-4459	195	3	nanoparticles	nanoparticle	NOUN
ijpds-4459	195	4	:	:	PUNCT
ijpds-4459	195	5	these	these	DET
ijpds-4459	195	6	miniature	miniature	ADJ
ijpds-4459	195	7	cargo	cargo	NOUN
ijpds-4459	195	8	ships	ship	NOUN
ijpds-4459	195	9	can	can	AUX
ijpds-4459	195	10	be	be	AUX
ijpds-4459	195	11	engineered	engineer	VERB
ijpds-4459	195	12	to	to	PART
ijpds-4459	195	13	carry	carry	VERB
ijpds-4459	195	14	crispr	crispr	ADJ
ijpds-4459	195	15	-	-	PUNCT
ijpds-4459	195	16	cas9	cas9	NOUN
ijpds-4459	195	17	components	component	NOUN
ijpds-4459	195	18	and	and	CCONJ
ijpds-4459	195	19	adorned	adorn	VERB
ijpds-4459	195	20	with	with	ADP
ijpds-4459	195	21	ligands	ligand	NOUN
ijpds-4459	195	22	that	that	PRON
ijpds-4459	195	23	bind	bind	VERB
ijpds-4459	195	24	to	to	ADP
ijpds-4459	195	25	receptors	receptor	NOUN
ijpds-4459	195	26	unique	unique	ADJ
ijpds-4459	195	27	to	to	ADP
ijpds-4459	195	28	specific	specific	ADJ
ijpds-4459	195	29	tissues	tissue	NOUN
ijpds-4459	195	30	.	.	PUNCT
ijpds-4459	196	1	this	this	DET
ijpds-4459	196	2	targeted	target	VERB
ijpds-4459	196	3	delivery	delivery	NOUN
ijpds-4459	196	4	approach	approach	NOUN
ijpds-4459	196	5	minimizes	minimize	VERB
ijpds-4459	196	6	off	off	ADP
ijpds-4459	196	7	-	-	PUNCT
ijpds-4459	196	8	target	target	NOUN
ijpds-4459	196	9	effects	effect	NOUN
ijpds-4459	196	10	and	and	CCONJ
ijpds-4459	196	11	enhances	enhance	VERB
ijpds-4459	196	12	overall	overall	ADJ
ijpds-4459	196	13	efficiency	efficiency	NOUN
ijpds-4459	196	14	.	.	PUNCT
ijpds-4459	197	1	for	for	ADP
ijpds-4459	197	2	example	example	NOUN
ijpds-4459	197	3	,	,	PUNCT
ijpds-4459	197	4	researchers	researcher	NOUN
ijpds-4459	197	5	at	at	ADP
ijpds-4459	197	6	mit	mit	NOUN
ijpds-4459	197	7	crafted	craft	VERB
ijpds-4459	197	8	nanoparticles	nanoparticle	NOUN
ijpds-4459	197	9	coated	coat	VERB
ijpds-4459	197	10	with	with	ADP
ijpds-4459	197	11	folate	folate	NOUN
ijpds-4459	197	12	ligands	ligand	NOUN
ijpds-4459	197	13	,	,	PUNCT
ijpds-4459	197	14	precisely	precisely	ADV
ijpds-4459	197	15	targeting	target	VERB
ijpds-4459	197	16	receptors	receptor	NOUN
ijpds-4459	197	17	abundant	abundant	ADJ
ijpds-4459	197	18	on	on	ADP
ijpds-4459	197	19	cancer	cancer	NOUN
ijpds-4459	197	20	cells	cell	NOUN
ijpds-4459	197	21	,	,	PUNCT
ijpds-4459	197	22	enabling	enable	VERB
ijpds-4459	197	23	gene	gene	NOUN
ijpds-4459	197	24	editing	edit	VERB
ijpds-4459	197	25	specifically	specifically	ADV
ijpds-4459	197	26	within	within	ADP
ijpds-4459	197	27	tumors	tumor	NOUN
ijpds-4459	197	28	and	and	CCONJ
ijpds-4459	197	29	laying	lay	VERB
ijpds-4459	197	30	the	the	DET
ijpds-4459	197	31	groundwork	groundwork	NOUN
ijpds-4459	197	32	for	for	ADP
ijpds-4459	197	33	personalized	personalized	ADJ
ijpds-4459	197	34	cancer	cancer	NOUN
ijpds-4459	197	35	therapies	therapy	NOUN
ijpds-4459	197	36	[	[	X
ijpds-4459	197	37	41,42	41,42	NOUN
ijpds-4459	197	38	]	]	PUNCT
ijpds-4459	197	39	.	.	PUNCT
ijpds-4459	198	1	g.	g.	PROPN
ijpds-4459	198	2	controlled	control	VERB
ijpds-4459	198	3	-	-	PUNCT
ijpds-4459	198	4	release	release	NOUN
ijpds-4459	198	5	scaffolds	scaffold	NOUN
ijpds-4459	198	6	:	:	PUNCT
ijpds-4459	198	7	these	these	DET
ijpds-4459	198	8	biomaterials	biomaterial	NOUN
ijpds-4459	198	9	function	function	VERB
ijpds-4459	198	10	as	as	ADP
ijpds-4459	198	11	custodians	custodian	NOUN
ijpds-4459	198	12	,	,	PUNCT
ijpds-4459	198	13	encapsulating	encapsulate	VERB
ijpds-4459	198	14	crispr	crispr	ADJ
ijpds-4459	198	15	-	-	PUNCT
ijpds-4459	198	16	cas9	cas9	NOUN
ijpds-4459	198	17	components	component	NOUN
ijpds-4459	198	18	and	and	CCONJ
ijpds-4459	198	19	releasing	release	VERB
ijpds-4459	198	20	them	they	PRON
ijpds-4459	198	21	gradually	gradually	ADV
ijpds-4459	198	22	over	over	ADP
ijpds-4459	198	23	time	time	NOUN
ijpds-4459	198	24	.	.	PUNCT
ijpds-4459	199	1	this	this	PRON
ijpds-4459	199	2	controlled	control	VERB
ijpds-4459	199	3	,	,	PUNCT
ijpds-4459	199	4	sustained	sustained	ADJ
ijpds-4459	199	5	delivery	delivery	NOUN
ijpds-4459	199	6	mechanism	mechanism	NOUN
ijpds-4459	199	7	ensures	ensure	VERB
ijpds-4459	199	8	localized	localized	ADJ
ijpds-4459	199	9	gene	gene	NOUN
ijpds-4459	199	10	editing	edit	VERB
ijpds-4459	199	11	within	within	ADP
ijpds-4459	199	12	the	the	DET
ijpds-4459	199	13	target	target	NOUN
ijpds-4459	199	14	area	area	NOUN
ijpds-4459	199	15	,	,	PUNCT
ijpds-4459	199	16	amplifying	amplify	VERB
ijpds-4459	199	17	the	the	DET
ijpds-4459	199	18	therapeutic	therapeutic	ADJ
ijpds-4459	199	19	impact	impact	NOUN
ijpds-4459	199	20	.	.	PUNCT
ijpds-4459	200	1	for	for	ADP
ijpds-4459	200	2	instance	instance	NOUN
ijpds-4459	200	3	,	,	PUNCT
ijpds-4459	200	4	a	a	DET
ijpds-4459	200	5	biodegradable	biodegradable	ADJ
ijpds-4459	200	6	hydrogel	hydrogel	NOUN
ijpds-4459	200	7	scaffold	scaffold	NOUN
ijpds-4459	200	8	loaded	load	VERB
ijpds-4459	200	9	with	with	ADP
ijpds-4459	200	10	crispr	crispr	NOUN
ijpds-4459	200	11	-	-	PUNCT
ijpds-4459	200	12	cas9	cas9	NOUN
ijpds-4459	200	13	was	be	AUX
ijpds-4459	200	14	employed	employ	VERB
ijpds-4459	200	15	to	to	PART
ijpds-4459	200	16	treat	treat	VERB
ijpds-4459	200	17	leber	leber	PROPN
ijpds-4459	200	18	's	's	PART
ijpds-4459	200	19	hereditary	hereditary	ADJ
ijpds-4459	200	20	optic	optic	NOUN
ijpds-4459	200	21	neuropathy	neuropathy	ADJ
ijpds-4459	200	22	,	,	PUNCT
ijpds-4459	200	23	a	a	DET
ijpds-4459	200	24	challenging	challenging	ADJ
ijpds-4459	200	25	mitochondrial	mitochondrial	ADJ
ijpds-4459	200	26	disease	disease	NOUN
ijpds-4459	200	27	affecting	affect	VERB
ijpds-4459	200	28	the	the	DET
ijpds-4459	200	29	retina	retina	NOUN
ijpds-4459	200	30	.	.	PUNCT
ijpds-4459	201	1	this	this	DET
ijpds-4459	201	2	localized	localized	ADJ
ijpds-4459	201	3	editing	editing	NOUN
ijpds-4459	201	4	within	within	ADP
ijpds-4459	201	5	the	the	DET
ijpds-4459	201	6	eye	eye	NOUN
ijpds-4459	201	7	demonstrated	demonstrate	VERB
ijpds-4459	201	8	improved	improved	ADJ
ijpds-4459	201	9	vision	vision	NOUN
ijpds-4459	201	10	in	in	ADP
ijpds-4459	201	11	animal	animal	NOUN
ijpds-4459	201	12	models	model	NOUN
ijpds-4459	201	13	,	,	PUNCT
ijpds-4459	201	14	offering	offer	VERB
ijpds-4459	201	15	promise	promise	NOUN
ijpds-4459	201	16	for	for	ADP
ijpds-4459	201	17	conditions	condition	NOUN
ijpds-4459	201	18	previously	previously	ADV
ijpds-4459	201	19	deemed	deem	VERB
ijpds-4459	201	20	untreatable	untreatable	ADJ
ijpds-4459	201	21	[	[	X
ijpds-4459	201	22	20,35,36	20,35,36	NUM
ijpds-4459	201	23	]	]	PUNCT
ijpds-4459	201	24	.	.	PUNCT
ijpds-4459	202	1	bhat	bhat	PROPN
ijpds-4459	202	2	&	&	CCONJ
ijpds-4459	202	3	shanbhag	shanbhag	NOUN
ijpds-4459	202	4	biomaterials	biomaterial	NOUN
ijpds-4459	202	5	:	:	PUNCT
ijpds-4459	202	6	revolutionizing	revolutionize	VERB
ijpds-4459	202	7	cancer	cancer	NOUN
ijpds-4459	202	8	immunotherapy	immunotherapy	NOUN
ijpds-4459	202	9	and	and	CCONJ
ijpds-4459	202	10	genomics	genomics	NOUN
ijpds-4459	202	11	vol	vol	NOUN
ijpds-4459	202	12	3	3	NUM
ijpds-4459	202	13	|	|	NOUN
ijpds-4459	202	14	issue	issue	NOUN
ijpds-4459	202	15	2	2	NUM
ijpds-4459	202	16	|	|	ADV
ijpds-4459	202	17	apr	apr	NOUN
ijpds-4459	202	18	–	–	PUNCT
ijpds-4459	202	19	jun	jun	PROPN
ijpds-4459	202	20	2024	2024	NUM
ijpds-4459	202	21	indian	indian	PROPN
ijpds-4459	202	22	j	j	PROPN
ijpds-4459	202	23	pharm	pharm	PROPN
ijpds-4459	202	24	drug	drug	PROPN
ijpds-4459	202	25	studies	study	NOUN
ijpds-4459	202	26	|	|	ADV
ijpds-4459	202	27	42	42	NUM
ijpds-4459	202	28	h.	h.	NOUN
ijpds-4459	202	29	engineered	engineer	VERB
ijpds-4459	202	30	viral	viral	ADJ
ijpds-4459	202	31	vectors	vector	NOUN
ijpds-4459	202	32	:	:	PUNCT
ijpds-4459	203	1	repurposed	repurpose	VERB
ijpds-4459	203	2	viruses	virus	NOUN
ijpds-4459	203	3	can	can	AUX
ijpds-4459	203	4	be	be	AUX
ijpds-4459	203	5	adeptly	adeptly	ADV
ijpds-4459	203	6	delivered	deliver	VERB
ijpds-4459	203	7	into	into	ADP
ijpds-4459	203	8	cells	cell	NOUN
ijpds-4459	203	9	,	,	PUNCT
ijpds-4459	203	10	with	with	ADP
ijpds-4459	203	11	their	their	PRON
ijpds-4459	203	12	capsids	capsid	NOUN
ijpds-4459	203	13	(	(	PUNCT
ijpds-4459	203	14	outer	outer	ADJ
ijpds-4459	203	15	shells	shell	NOUN
ijpds-4459	203	16	)	)	PUNCT
ijpds-4459	203	17	and	and	CCONJ
ijpds-4459	203	18	promoters	promoter	NOUN
ijpds-4459	203	19	(	(	PUNCT
ijpds-4459	203	20	genetic	genetic	ADJ
ijpds-4459	203	21	switches	switch	NOUN
ijpds-4459	203	22	)	)	PUNCT
ijpds-4459	203	23	meticulously	meticulously	ADV
ijpds-4459	203	24	engineered	engineer	VERB
ijpds-4459	203	25	to	to	PART
ijpds-4459	203	26	target	target	VERB
ijpds-4459	203	27	specific	specific	ADJ
ijpds-4459	203	28	tissues	tissue	NOUN
ijpds-4459	203	29	.	.	PUNCT
ijpds-4459	204	1	this	this	DET
ijpds-4459	204	2	targeted	target	VERB
ijpds-4459	204	3	delivery	delivery	NOUN
ijpds-4459	204	4	strategy	strategy	NOUN
ijpds-4459	204	5	ensures	ensure	VERB
ijpds-4459	204	6	that	that	SCONJ
ijpds-4459	204	7	the	the	DET
ijpds-4459	204	8	editing	edit	VERB
ijpds-4459	204	9	machinery	machinery	NOUN
ijpds-4459	204	10	reaches	reach	VERB
ijpds-4459	204	11	its	its	PRON
ijpds-4459	204	12	intended	intend	VERB
ijpds-4459	204	13	destination	destination	NOUN
ijpds-4459	204	14	,	,	PUNCT
ijpds-4459	204	15	minimizing	minimize	VERB
ijpds-4459	204	16	risks	risk	NOUN
ijpds-4459	204	17	and	and	CCONJ
ijpds-4459	204	18	maximizing	maximize	VERB
ijpds-4459	204	19	efficacy	efficacy	NOUN
ijpds-4459	204	20	.	.	PUNCT
ijpds-4459	205	1	for	for	ADP
ijpds-4459	205	2	example	example	NOUN
ijpds-4459	205	3	,	,	PUNCT
ijpds-4459	205	4	scientists	scientist	NOUN
ijpds-4459	205	5	modified	modify	VERB
ijpds-4459	205	6	an	an	DET
ijpds-4459	205	7	aav	aav	NOUN
ijpds-4459	205	8	vector	vector	NOUN
ijpds-4459	205	9	with	with	ADP
ijpds-4459	205	10	a	a	DET
ijpds-4459	205	11	muscle	muscle	NOUN
ijpds-4459	205	12	-	-	PUNCT
ijpds-4459	205	13	specific	specific	ADJ
ijpds-4459	205	14	promoter	promoter	NOUN
ijpds-4459	205	15	,	,	PUNCT
ijpds-4459	205	16	not	not	PART
ijpds-4459	205	17	only	only	ADV
ijpds-4459	205	18	delivering	deliver	VERB
ijpds-4459	205	19	crispr	crispr	NOUN
ijpds-4459	205	20	-	-	PUNCT
ijpds-4459	205	21	cas9	cas9	NOUN
ijpds-4459	205	22	but	but	CCONJ
ijpds-4459	205	23	correcting	correct	VERB
ijpds-4459	205	24	a	a	DET
ijpds-4459	205	25	mutation	mutation	NOUN
ijpds-4459	205	26	causing	cause	VERB
ijpds-4459	205	27	duchenne	duchenne	ADJ
ijpds-4459	205	28	muscular	muscular	ADJ
ijpds-4459	205	29	dystrophy	dystrophy	NOUN
ijpds-4459	205	30	in	in	ADP
ijpds-4459	205	31	muscle	muscle	NOUN
ijpds-4459	205	32	cells	cell	NOUN
ijpds-4459	205	33	.	.	PUNCT
ijpds-4459	206	1	the	the	DET
ijpds-4459	206	2	result	result	NOUN
ijpds-4459	206	3	:	:	PUNCT
ijpds-4459	206	4	significant	significant	ADJ
ijpds-4459	206	5	improvements	improvement	NOUN
ijpds-4459	206	6	in	in	ADP
ijpds-4459	206	7	muscle	muscle	NOUN
ijpds-4459	206	8	function	function	NOUN
ijpds-4459	206	9	observed	observe	VERB
ijpds-4459	206	10	in	in	ADP
ijpds-4459	206	11	animal	animal	NOUN
ijpds-4459	206	12	models	model	NOUN
ijpds-4459	206	13	[	[	X
ijpds-4459	206	14	48,49	48,49	X
ijpds-4459	206	15	]	]	PUNCT
ijpds-4459	206	16	.	.	PUNCT
ijpds-4459	207	1	i.	i.	PROPN
ijpds-4459	207	2	beyond	beyond	ADP
ijpds-4459	207	3	delivery	delivery	NOUN
ijpds-4459	207	4	:	:	PUNCT
ijpds-4459	207	5	researchers	researcher	NOUN
ijpds-4459	207	6	are	be	AUX
ijpds-4459	207	7	advancing	advance	VERB
ijpds-4459	207	8	high	high	ADJ
ijpds-4459	207	9	-	-	PUNCT
ijpds-4459	207	10	fidelity	fidelity	NOUN
ijpds-4459	207	11	cas9	cas9	NOUN
ijpds-4459	207	12	enzymes	enzyme	NOUN
ijpds-4459	207	13	and	and	CCONJ
ijpds-4459	207	14	guide	guide	VERB
ijpds-4459	207	15	rnas	rna	NOUN
ijpds-4459	207	16	with	with	ADP
ijpds-4459	207	17	heightened	heightened	ADJ
ijpds-4459	207	18	specificity	specificity	NOUN
ijpds-4459	207	19	,	,	PUNCT
ijpds-4459	207	20	reducing	reduce	VERB
ijpds-4459	207	21	the	the	DET
ijpds-4459	207	22	risk	risk	NOUN
ijpds-4459	207	23	of	of	ADP
ijpds-4459	207	24	unintended	unintended	ADJ
ijpds-4459	207	25	edits	edit	NOUN
ijpds-4459	207	26	.	.	PUNCT
ijpds-4459	208	1	strategies	strategy	NOUN
ijpds-4459	208	2	involve	involve	VERB
ijpds-4459	208	3	sustained	sustained	ADJ
ijpds-4459	208	4	delivery	delivery	NOUN
ijpds-4459	208	5	systems	system	NOUN
ijpds-4459	208	6	or	or	CCONJ
ijpds-4459	208	7	inducible	inducible	ADJ
ijpds-4459	208	8	editing	editing	NOUN
ijpds-4459	208	9	approaches	approach	NOUN
ijpds-4459	208	10	to	to	PART
ijpds-4459	208	11	enhance	enhance	VERB
ijpds-4459	208	12	the	the	DET
ijpds-4459	208	13	persistence	persistence	NOUN
ijpds-4459	208	14	of	of	ADP
ijpds-4459	208	15	gene	gene	NOUN
ijpds-4459	208	16	editing	editing	NOUN
ijpds-4459	208	17	.	.	PUNCT
ijpds-4459	209	1	careful	careful	ADJ
ijpds-4459	209	2	consideration	consideration	NOUN
ijpds-4459	209	3	of	of	ADP
ijpds-4459	209	4	ethical	ethical	ADJ
ijpds-4459	209	5	implications	implication	NOUN
ijpds-4459	209	6	,	,	PUNCT
ijpds-4459	209	7	especially	especially	ADV
ijpds-4459	209	8	concerning	concern	VERB
ijpds-4459	209	9	germline	germline	NOUN
ijpds-4459	209	10	editing	editing	NOUN
ijpds-4459	209	11	and	and	CCONJ
ijpds-4459	209	12	equitable	equitable	ADJ
ijpds-4459	209	13	access	access	NOUN
ijpds-4459	209	14	,	,	PUNCT
ijpds-4459	209	15	is	be	AUX
ijpds-4459	209	16	crucial	crucial	ADJ
ijpds-4459	209	17	for	for	ADP
ijpds-4459	209	18	responsible	responsible	ADJ
ijpds-4459	209	19	development	development	NOUN
ijpds-4459	209	20	[	[	X
ijpds-4459	209	21	20,28,52	20,28,52	NUM
ijpds-4459	209	22	]	]	PUNCT
ijpds-4459	209	23	.	.	PUNCT
ijpds-4459	210	1	figure	figure	NOUN
ijpds-4459	210	2	2	2	NUM
ijpds-4459	210	3	.	.	PUNCT
ijpds-4459	210	4	in	in	ADP
ijpds-4459	210	5	-	-	PUNCT
ijpds-4459	210	6	vivo	vivo	NOUN
ijpds-4459	210	7	gene	gene	NOUN
ijpds-4459	210	8	editing	editing	NOUN
ijpds-4459	210	9	.	.	PUNCT
ijpds-4459	211	1	challenges	challenge	NOUN
ijpds-4459	211	2	and	and	CCONJ
ijpds-4459	211	3	future	future	ADJ
ijpds-4459	211	4	directions	direction	NOUN
ijpds-4459	211	5	in	in	ADP
ijpds-4459	211	6	biomaterials	biomaterial	NOUN
ijpds-4459	211	7	for	for	ADP
ijpds-4459	211	8	cancer	cancer	NOUN
ijpds-4459	211	9	immunotherapy	immunotherapy	NOUN
ijpds-4459	211	10	and	and	CCONJ
ijpds-4459	211	11	genome	genome	NOUN
ijpds-4459	211	12	editing	editing	NOUN
ijpds-4459	211	13	.	.	PUNCT
ijpds-4459	212	1	the	the	DET
ijpds-4459	212	2	development	development	NOUN
ijpds-4459	212	3	of	of	ADP
ijpds-4459	212	4	biomaterial	biomaterial	NOUN
ijpds-4459	212	5	-	-	PUNCT
ijpds-4459	212	6	based	base	VERB
ijpds-4459	212	7	therapies	therapy	NOUN
ijpds-4459	212	8	presents	present	VERB
ijpds-4459	212	9	a	a	DET
ijpds-4459	212	10	myriad	myriad	NOUN
ijpds-4459	212	11	of	of	ADP
ijpds-4459	212	12	complex	complex	ADJ
ijpds-4459	212	13	challenges	challenge	NOUN
ijpds-4459	212	14	that	that	PRON
ijpds-4459	212	15	necessitate	necessitate	ADJ
ijpds-4459	212	16	rigorous	rigorous	ADJ
ijpds-4459	212	17	scientific	scientific	ADJ
ijpds-4459	212	18	investigation	investigation	NOUN
ijpds-4459	212	19	and	and	CCONJ
ijpds-4459	212	20	innovative	innovative	ADJ
ijpds-4459	212	21	solutions	solution	NOUN
ijpds-4459	212	22	[	[	X
ijpds-4459	212	23	53	53	NUM
ijpds-4459	212	24	]	]	PUNCT
ijpds-4459	212	25	.	.	PUNCT
ijpds-4459	213	1	foremost	foremost	ADV
ijpds-4459	213	2	among	among	ADP
ijpds-4459	213	3	these	these	DET
ijpds-4459	213	4	challenges	challenge	NOUN
ijpds-4459	213	5	is	be	AUX
ijpds-4459	213	6	the	the	DET
ijpds-4459	213	7	imperative	imperative	NOUN
ijpds-4459	213	8	to	to	PART
ijpds-4459	213	9	ensure	ensure	VERB
ijpds-4459	213	10	safety	safety	NOUN
ijpds-4459	213	11	and	and	CCONJ
ijpds-4459	213	12	biocompatibility	biocompatibility	NOUN
ijpds-4459	213	13	.	.	PUNCT
ijpds-4459	214	1	as	as	SCONJ
ijpds-4459	214	2	these	these	DET
ijpds-4459	214	3	biomaterials	biomaterial	NOUN
ijpds-4459	214	4	interact	interact	VERB
ijpds-4459	214	5	intimately	intimately	ADV
ijpds-4459	214	6	with	with	ADP
ijpds-4459	214	7	the	the	DET
ijpds-4459	214	8	patient	patient	NOUN
ijpds-4459	214	9	's	's	PART
ijpds-4459	214	10	immune	immune	ADJ
ijpds-4459	214	11	system	system	NOUN
ijpds-4459	214	12	and	and	CCONJ
ijpds-4459	214	13	biological	biological	ADJ
ijpds-4459	214	14	processes	process	NOUN
ijpds-4459	214	15	,	,	PUNCT
ijpds-4459	214	16	a	a	DET
ijpds-4459	214	17	comprehensive	comprehensive	ADJ
ijpds-4459	214	18	assessment	assessment	NOUN
ijpds-4459	214	19	of	of	ADP
ijpds-4459	214	20	their	their	PRON
ijpds-4459	214	21	biocompatibility	biocompatibility	NOUN
ijpds-4459	214	22	is	be	AUX
ijpds-4459	214	23	essential	essential	ADJ
ijpds-4459	214	24	to	to	PART
ijpds-4459	214	25	mitigate	mitigate	VERB
ijpds-4459	214	26	the	the	DET
ijpds-4459	214	27	risk	risk	NOUN
ijpds-4459	214	28	of	of	ADP
ijpds-4459	214	29	adverse	adverse	ADJ
ijpds-4459	214	30	reactions	reaction	NOUN
ijpds-4459	214	31	or	or	CCONJ
ijpds-4459	214	32	immune	immune	ADJ
ijpds-4459	214	33	responses	response	NOUN
ijpds-4459	214	34	[	[	X
ijpds-4459	214	35	17,54	17,54	NUM
ijpds-4459	214	36	]	]	PUNCT
ijpds-4459	214	37	.	.	PUNCT
ijpds-4459	215	1	this	this	PRON
ijpds-4459	215	2	extends	extend	VERB
ijpds-4459	215	3	to	to	ADP
ijpds-4459	215	4	the	the	DET
ijpds-4459	215	5	imperative	imperative	NOUN
ijpds-4459	215	6	of	of	ADP
ijpds-4459	215	7	long	long	ADJ
ijpds-4459	215	8	-	-	PUNCT
ijpds-4459	215	9	term	term	NOUN
ijpds-4459	215	10	evaluation	evaluation	NOUN
ijpds-4459	215	11	of	of	ADP
ijpds-4459	215	12	the	the	DET
ijpds-4459	215	13	effects	effect	NOUN
ijpds-4459	215	14	of	of	ADP
ijpds-4459	215	15	biomaterials	biomaterial	NOUN
ijpds-4459	215	16	,	,	PUNCT
ijpds-4459	215	17	especially	especially	ADV
ijpds-4459	215	18	when	when	SCONJ
ijpds-4459	215	19	employed	employ	VERB
ijpds-4459	215	20	in	in	ADP
ijpds-4459	215	21	the	the	DET
ijpds-4459	215	22	context	context	NOUN
ijpds-4459	215	23	of	of	ADP
ijpds-4459	215	24	chronic	chronic	ADJ
ijpds-4459	215	25	treatments	treatment	NOUN
ijpds-4459	215	26	,	,	PUNCT
ijpds-4459	215	27	where	where	SCONJ
ijpds-4459	215	28	potential	potential	ADJ
ijpds-4459	215	29	impacts	impact	NOUN
ijpds-4459	215	30	must	must	AUX
ijpds-4459	215	31	be	be	AUX
ijpds-4459	215	32	thoroughly	thoroughly	ADV
ijpds-4459	215	33	understood	understand	VERB
ijpds-4459	215	34	[	[	X
ijpds-4459	215	35	17,53,54	17,53,54	NUM
ijpds-4459	215	36	]	]	X
ijpds-4459	215	37	.	.	PUNCT
ijpds-4459	216	1	efficient	efficient	ADJ
ijpds-4459	216	2	delivery	delivery	NOUN
ijpds-4459	216	3	and	and	CCONJ
ijpds-4459	216	4	precise	precise	ADJ
ijpds-4459	216	5	targeting	targeting	NOUN
ijpds-4459	216	6	represent	represent	VERB
ijpds-4459	216	7	pivotal	pivotal	ADJ
ijpds-4459	216	8	facets	facet	NOUN
ijpds-4459	216	9	of	of	ADP
ijpds-4459	216	10	therapeutic	therapeutic	ADJ
ijpds-4459	216	11	success	success	NOUN
ijpds-4459	216	12	.	.	PUNCT
ijpds-4459	217	1	achieving	achieve	VERB
ijpds-4459	217	2	optimal	optimal	ADJ
ijpds-4459	217	3	outcomes	outcome	NOUN
ijpds-4459	217	4	hinges	hinge	NOUN
ijpds-4459	217	5	on	on	ADP
ijpds-4459	217	6	enhancing	enhance	VERB
ijpds-4459	217	7	the	the	DET
ijpds-4459	217	8	delivery	delivery	NOUN
ijpds-4459	217	9	efficiency	efficiency	NOUN
ijpds-4459	217	10	of	of	ADP
ijpds-4459	217	11	biomaterials	biomaterial	NOUN
ijpds-4459	217	12	,	,	PUNCT
ijpds-4459	217	13	particularly	particularly	ADV
ijpds-4459	217	14	in	in	ADP
ijpds-4459	217	15	the	the	DET
ijpds-4459	217	16	often	often	ADJ
ijpds-4459	217	17	-	-	PUNCT
ijpds-4459	217	18	hostiletumor	hostiletumor	NOUN
ijpds-4459	217	19	microenvironments	microenvironment	NOUN
ijpds-4459	217	20	[	[	X
ijpds-4459	217	21	55	55	NUM
ijpds-4459	217	22	]	]	PUNCT
ijpds-4459	217	23	.	.	PUNCT
ijpds-4459	218	1	innovative	innovative	ADJ
ijpds-4459	218	2	strategies	strategy	NOUN
ijpds-4459	218	3	must	must	AUX
ijpds-4459	218	4	be	be	AUX
ijpds-4459	218	5	devised	devise	VERB
ijpds-4459	218	6	to	to	PART
ijpds-4459	218	7	bolster	bolster	VERB
ijpds-4459	218	8	the	the	DET
ijpds-4459	218	9	targeting	target	VERB
ijpds-4459	218	10	specificity	specificity	NOUN
ijpds-4459	218	11	and	and	CCONJ
ijpds-4459	218	12	improve	improve	VERB
ijpds-4459	218	13	tissue	tissue	NOUN
ijpds-4459	218	14	penetration	penetration	NOUN
ijpds-4459	218	15	,	,	PUNCT
ijpds-4459	218	16	addressing	address	VERB
ijpds-4459	218	17	the	the	DET
ijpds-4459	218	18	unique	unique	ADJ
ijpds-4459	218	19	challenges	challenge	NOUN
ijpds-4459	218	20	presented	present	VERB
ijpds-4459	218	21	by	by	ADP
ijpds-4459	218	22	biomaterial	biomaterial	ADJ
ijpds-4459	218	23	-	-	PUNCT
ijpds-4459	218	24	based	base	VERB
ijpds-4459	218	25	therapies	therapy	NOUN
ijpds-4459	218	26	.	.	PUNCT
ijpds-4459	219	1	the	the	DET
ijpds-4459	219	2	potential	potential	ADJ
ijpds-4459	219	3	immunogenicity	immunogenicity	NOUN
ijpds-4459	219	4	of	of	ADP
ijpds-4459	219	5	certain	certain	ADJ
ijpds-4459	219	6	biomaterials	biomaterial	NOUN
ijpds-4459	219	7	,	,	PUNCT
ijpds-4459	219	8	notably	notably	ADV
ijpds-4459	219	9	viral	viral	ADJ
ijpds-4459	219	10	vectors	vector	NOUN
ijpds-4459	219	11	,	,	PUNCT
ijpds-4459	219	12	poses	pose	VERB
ijpds-4459	219	13	a	a	DET
ijpds-4459	219	14	substantial	substantial	ADJ
ijpds-4459	219	15	concern	concern	NOUN
ijpds-4459	219	16	,	,	PUNCT
ijpds-4459	219	17	potentially	potentially	ADV
ijpds-4459	219	18	limiting	limit	VERB
ijpds-4459	219	19	their	their	PRON
ijpds-4459	219	20	effectiveness	effectiveness	NOUN
ijpds-4459	219	21	upon	upon	SCONJ
ijpds-4459	219	22	repeated	repeat	VERB
ijpds-4459	219	23	administration	administration	NOUN
ijpds-4459	219	24	[	[	X
ijpds-4459	219	25	56,57	56,57	NOUN
ijpds-4459	219	26	]	]	X
ijpds-4459	219	27	.	.	PUNCT
ijpds-4459	220	1	therefore	therefore	ADV
ijpds-4459	220	2	,	,	PUNCT
ijpds-4459	220	3	it	it	PRON
ijpds-4459	220	4	is	be	AUX
ijpds-4459	220	5	imperative	imperative	ADJ
ijpds-4459	220	6	to	to	PART
ijpds-4459	220	7	explore	explore	VERB
ijpds-4459	220	8	avenues	avenue	NOUN
ijpds-4459	220	9	for	for	ADP
ijpds-4459	220	10	mitigating	mitigate	VERB
ijpds-4459	220	11	immunogenicity	immunogenicity	NOUN
ijpds-4459	220	12	without	without	ADP
ijpds-4459	220	13	compromising	compromise	VERB
ijpds-4459	220	14	therapeutic	therapeutic	ADJ
ijpds-4459	220	15	efficacy	efficacy	NOUN
ijpds-4459	220	16	[	[	X
ijpds-4459	220	17	57	57	NUM
ijpds-4459	220	18	]	]	PUNCT
ijpds-4459	220	19	.	.	PUNCT
ijpds-4459	221	1	this	this	PRON
ijpds-4459	221	2	calls	call	VERB
ijpds-4459	221	3	for	for	ADP
ijpds-4459	221	4	the	the	DET
ijpds-4459	221	5	development	development	NOUN
ijpds-4459	221	6	of	of	ADP
ijpds-4459	221	7	novel	novel	ADJ
ijpds-4459	221	8	biomaterials	biomaterial	NOUN
ijpds-4459	221	9	engineered	engineer	VERB
ijpds-4459	221	10	to	to	PART
ijpds-4459	221	11	exhibit	exhibit	VERB
ijpds-4459	221	12	reduced	reduce	VERB
ijpds-4459	221	13	immunogenic	immunogenic	ADJ
ijpds-4459	221	14	potential	potential	NOUN
ijpds-4459	221	15	or	or	CCONJ
ijpds-4459	221	16	the	the	DET
ijpds-4459	221	17	implementation	implementation	NOUN
ijpds-4459	221	18	of	of	ADP
ijpds-4459	221	19	immune	immune	ADJ
ijpds-4459	221	20	-	-	PUNCT
ijpds-4459	221	21	evasion	evasion	NOUN
ijpds-4459	221	22	strategies	strategy	NOUN
ijpds-4459	221	23	to	to	PART
ijpds-4459	221	24	enhance	enhance	VERB
ijpds-4459	221	25	their	their	PRON
ijpds-4459	221	26	clinical	clinical	ADJ
ijpds-4459	221	27	applicability	applicability	NOUN
ijpds-4459	221	28	[	[	X
ijpds-4459	221	29	58	58	NUM
ijpds-4459	221	30	]	]	PUNCT
ijpds-4459	221	31	.	.	PUNCT
ijpds-4459	222	1	off	off	ADP
ijpds-4459	222	2	-	-	PUNCT
ijpds-4459	222	3	target	target	NOUN
ijpds-4459	222	4	effects	effect	NOUN
ijpds-4459	222	5	,	,	PUNCT
ijpds-4459	222	6	a	a	DET
ijpds-4459	222	7	notable	notable	ADJ
ijpds-4459	222	8	challenge	challenge	NOUN
ijpds-4459	222	9	in	in	ADP
ijpds-4459	222	10	gene	gene	NOUN
ijpds-4459	222	11	editing	edit	VERB
ijpds-4459	222	12	therapies	therapy	NOUN
ijpds-4459	222	13	,	,	PUNCT
ijpds-4459	222	14	where	where	SCONJ
ijpds-4459	222	15	crispr	crispr	NOUN
ijpds-4459	222	16	-	-	PUNCT
ijpds-4459	222	17	cas9	cas9	NOUN
ijpds-4459	222	18	may	may	AUX
ijpds-4459	222	19	inadvertently	inadvertently	ADV
ijpds-4459	222	20	edit	edit	VERB
ijpds-4459	222	21	unintended	unintended	ADJ
ijpds-4459	222	22	genomic	genomic	NOUN
ijpds-4459	222	23	sites	site	NOUN
ijpds-4459	222	24	,	,	PUNCT
ijpds-4459	222	25	necessitate	necessitate	ADJ
ijpds-4459	222	26	continual	continual	ADJ
ijpds-4459	222	27	refinement	refinement	NOUN
ijpds-4459	222	28	of	of	ADP
ijpds-4459	222	29	the	the	DET
ijpds-4459	222	30	specificity	specificity	NOUN
ijpds-4459	222	31	and	and	CCONJ
ijpds-4459	222	32	accuracy	accuracy	NOUN
ijpds-4459	222	33	of	of	ADP
ijpds-4459	222	34	crispr	crispr	ADJ
ijpds-4459	222	35	-	-	PUNCT
ijpds-4459	222	36	cas9	cas9	NOUN
ijpds-4459	222	37	systems	system	NOUN
ijpds-4459	222	38	.	.	PUNCT
ijpds-4459	223	1	this	this	DET
ijpds-4459	223	2	ongoing	ongoing	ADJ
ijpds-4459	223	3	pursuit	pursuit	NOUN
ijpds-4459	223	4	aims	aim	VERB
ijpds-4459	223	5	to	to	PART
ijpds-4459	223	6	minimize	minimize	VERB
ijpds-4459	223	7	off	off	ADP
ijpds-4459	223	8	-	-	PUNCT
ijpds-4459	223	9	target	target	NOUN
ijpds-4459	223	10	effects	effect	NOUN
ijpds-4459	223	11	and	and	CCONJ
ijpds-4459	223	12	bolster	bolster	VERB
ijpds-4459	223	13	the	the	DET
ijpds-4459	223	14	safety	safety	NOUN
ijpds-4459	223	15	profile	profile	NOUN
ijpds-4459	223	16	of	of	ADP
ijpds-4459	223	17	genome	genome	NOUN
ijpds-4459	223	18	editing	edit	VERB
ijpds-4459	223	19	treatments	treatment	NOUN
ijpds-4459	223	20	[	[	X
ijpds-4459	223	21	59	59	NUM
ijpds-4459	223	22	]	]	PUNCT
ijpds-4459	223	23	.	.	PUNCT
ijpds-4459	224	1	practical	practical	ADJ
ijpds-4459	224	2	considerations	consideration	NOUN
ijpds-4459	224	3	regarding	regard	VERB
ijpds-4459	224	4	manufacturing	manufacture	VERB
ijpds-4459	224	5	scalability	scalability	NOUN
ijpds-4459	224	6	and	and	CCONJ
ijpds-4459	224	7	standardization	standardization	NOUN
ijpds-4459	224	8	come	come	VERB
ijpds-4459	224	9	to	to	ADP
ijpds-4459	224	10	the	the	DET
ijpds-4459	224	11	forefront	forefront	NOUN
ijpds-4459	224	12	.	.	PUNCT
ijpds-4459	225	1	ensuring	ensure	VERB
ijpds-4459	225	2	bhat	bhat	PROPN
ijpds-4459	225	3	&	&	CCONJ
ijpds-4459	225	4	shanbhag	shanbhag	NOUN
ijpds-4459	225	5	biomaterials	biomaterial	NOUN
ijpds-4459	225	6	:	:	PUNCT
ijpds-4459	225	7	revolutionizing	revolutionize	VERB
ijpds-4459	225	8	cancer	cancer	NOUN
ijpds-4459	225	9	immunotherapy	immunotherapy	NOUN
ijpds-4459	225	10	and	and	CCONJ
ijpds-4459	225	11	genomics	genomics	NOUN
ijpds-4459	225	12	vol	vol	NOUN
ijpds-4459	225	13	3	3	NUM
ijpds-4459	226	1	|	|	NOUN
ijpds-4459	226	2	issue	issue	NOUN
ijpds-4459	226	3	2	2	NUM
ijpds-4459	226	4	|	|	ADV
ijpds-4459	226	5	apr	apr	NOUN
ijpds-4459	226	6	–	–	PUNCT
ijpds-4459	226	7	jun	jun	PROPN
ijpds-4459	226	8	2024	2024	NUM
ijpds-4459	226	9	indian	indian	PROPN
ijpds-4459	226	10	j	j	PROPN
ijpds-4459	226	11	pharm	pharm	PROPN
ijpds-4459	226	12	drug	drug	PROPN
ijpds-4459	226	13	studies	study	NOUN
ijpds-4459	226	14	|	|	ADV
ijpds-4459	226	15	43	43	NUM
ijpds-4459	226	16	reproducibility	reproducibility	NOUN
ijpds-4459	226	17	,	,	PUNCT
ijpds-4459	226	18	quality	quality	NOUN
ijpds-4459	226	19	,	,	PUNCT
ijpds-4459	226	20	and	and	CCONJ
ijpds-4459	226	21	alignment	alignment	NOUN
ijpds-4459	226	22	with	with	ADP
ijpds-4459	226	23	regulatory	regulatory	ADJ
ijpds-4459	226	24	standards	standard	NOUN
ijpds-4459	226	25	is	be	AUX
ijpds-4459	226	26	imperative	imperative	ADJ
ijpds-4459	226	27	to	to	PART
ijpds-4459	226	28	meet	meet	VERB
ijpds-4459	226	29	the	the	DET
ijpds-4459	226	30	burgeoning	burgeon	VERB
ijpds-4459	226	31	demand	demand	NOUN
ijpds-4459	226	32	for	for	ADP
ijpds-4459	226	33	clinical	clinical	ADJ
ijpds-4459	226	34	trials	trial	NOUN
ijpds-4459	226	35	and	and	CCONJ
ijpds-4459	226	36	future	future	ADJ
ijpds-4459	226	37	commercialization	commercialization	NOUN
ijpds-4459	226	38	[	[	X
ijpds-4459	226	39	60	60	NUM
ijpds-4459	226	40	]	]	PUNCT
ijpds-4459	226	41	.	.	PUNCT
ijpds-4459	227	1	standardization	standardization	NOUN
ijpds-4459	227	2	of	of	ADP
ijpds-4459	227	3	manufacturing	manufacturing	NOUN
ijpds-4459	227	4	processes	process	NOUN
ijpds-4459	227	5	and	and	CCONJ
ijpds-4459	227	6	strict	strict	ADJ
ijpds-4459	227	7	adherence	adherence	NOUN
ijpds-4459	227	8	to	to	ADP
ijpds-4459	227	9	regulatory	regulatory	ADJ
ijpds-4459	227	10	compliance	compliance	NOUN
ijpds-4459	227	11	are	be	AUX
ijpds-4459	227	12	pivotal	pivotal	ADJ
ijpds-4459	227	13	for	for	ADP
ijpds-4459	227	14	the	the	DET
ijpds-4459	227	15	widespread	widespread	ADJ
ijpds-4459	227	16	adoption	adoption	NOUN
ijpds-4459	227	17	of	of	ADP
ijpds-4459	227	18	biomaterial	biomaterial	NOUN
ijpds-4459	227	19	-	-	PUNCT
ijpds-4459	227	20	based	base	VERB
ijpds-4459	227	21	therapies	therapy	NOUN
ijpds-4459	227	22	[	[	X
ijpds-4459	227	23	61	61	NUM
ijpds-4459	227	24	]	]	PUNCT
ijpds-4459	227	25	.	.	PUNCT
ijpds-4459	228	1	moreover	moreover	ADV
ijpds-4459	228	2	,	,	PUNCT
ijpds-4459	228	3	the	the	DET
ijpds-4459	228	4	vision	vision	NOUN
ijpds-4459	228	5	of	of	ADP
ijpds-4459	228	6	personalized	personalized	ADJ
ijpds-4459	228	7	medicine	medicine	NOUN
ijpds-4459	228	8	,	,	PUNCT
ijpds-4459	228	9	integral	integral	ADJ
ijpds-4459	228	10	to	to	ADP
ijpds-4459	228	11	both	both	PRON
ijpds-4459	228	12	cancer	cancer	NOUN
ijpds-4459	228	13	immunotherapy	immunotherapy	NOUN
ijpds-4459	228	14	and	and	CCONJ
ijpds-4459	228	15	genome	genome	NOUN
ijpds-4459	228	16	editing	editing	NOUN
ijpds-4459	228	17	,	,	PUNCT
ijpds-4459	228	18	requires	require	VERB
ijpds-4459	228	19	the	the	DET
ijpds-4459	228	20	seamless	seamless	ADJ
ijpds-4459	228	21	integration	integration	NOUN
ijpds-4459	228	22	of	of	ADP
ijpds-4459	228	23	biomaterials	biomaterial	NOUN
ijpds-4459	228	24	with	with	ADP
ijpds-4459	228	25	patient	patient	NOUN
ijpds-4459	228	26	-	-	PUNCT
ijpds-4459	228	27	specific	specific	ADJ
ijpds-4459	228	28	genomic	genomic	NOUN
ijpds-4459	228	29	and	and	CCONJ
ijpds-4459	228	30	immunological	immunological	ADJ
ijpds-4459	228	31	data	datum	NOUN
ijpds-4459	228	32	[	[	X
ijpds-4459	228	33	62	62	NUM
ijpds-4459	228	34	]	]	PUNCT
ijpds-4459	228	35	.	.	PUNCT
ijpds-4459	229	1	realizing	realize	VERB
ijpds-4459	229	2	this	this	DET
ijpds-4459	229	3	ambition	ambition	NOUN
ijpds-4459	229	4	hinges	hinge	NOUN
ijpds-4459	229	5	on	on	ADP
ijpds-4459	229	6	advancements	advancement	NOUN
ijpds-4459	229	7	in	in	ADP
ijpds-4459	229	8	high	high	ADJ
ijpds-4459	229	9	-	-	PUNCT
ijpds-4459	229	10	throughput	throughput	NOUN
ijpds-4459	229	11	sequencing	sequencing	NOUN
ijpds-4459	229	12	and	and	CCONJ
ijpds-4459	229	13	bioinformatics	bioinformatic	NOUN
ijpds-4459	229	14	,	,	PUNCT
ijpds-4459	229	15	which	which	PRON
ijpds-4459	229	16	are	be	AUX
ijpds-4459	229	17	poised	poise	VERB
ijpds-4459	229	18	to	to	PART
ijpds-4459	229	19	play	play	VERB
ijpds-4459	229	20	instrumental	instrumental	ADJ
ijpds-4459	229	21	roles	role	NOUN
ijpds-4459	229	22	in	in	ADP
ijpds-4459	229	23	optimizing	optimize	VERB
ijpds-4459	229	24	biomaterial	biomaterial	NOUN
ijpds-4459	229	25	-	-	PUNCT
ijpds-4459	229	26	based	base	VERB
ijpds-4459	229	27	therapies	therapy	NOUN
ijpds-4459	229	28	tailored	tailor	VERB
ijpds-4459	229	29	to	to	ADP
ijpds-4459	229	30	individual	individual	ADJ
ijpds-4459	229	31	patient	patient	ADJ
ijpds-4459	229	32	profiles	profile	NOUN
ijpds-4459	229	33	[	[	X
ijpds-4459	229	34	63	63	NUM
ijpds-4459	229	35	]	]	PUNCT
ijpds-4459	229	36	.	.	PUNCT
ijpds-4459	230	1	combination	combination	NOUN
ijpds-4459	230	2	therapies	therapy	NOUN
ijpds-4459	230	3	that	that	PRON
ijpds-4459	230	4	harness	harnes	VERB
ijpds-4459	230	5	the	the	DET
ijpds-4459	230	6	synergy	synergy	NOUN
ijpds-4459	230	7	between	between	ADP
ijpds-4459	230	8	diverse	diverse	ADJ
ijpds-4459	230	9	biomaterials	biomaterial	NOUN
ijpds-4459	230	10	,	,	PUNCT
ijpds-4459	230	11	immunotherapies	immunotherapy	NOUN
ijpds-4459	230	12	,	,	PUNCT
ijpds-4459	230	13	and	and	CCONJ
ijpds-4459	230	14	gene	gene	NOUN
ijpds-4459	230	15	editing	edit	VERB
ijpds-4459	230	16	strategies	strategy	NOUN
ijpds-4459	230	17	hold	hold	VERB
ijpds-4459	230	18	immense	immense	ADJ
ijpds-4459	230	19	promise	promise	NOUN
ijpds-4459	230	20	for	for	ADP
ijpds-4459	230	21	enhancing	enhance	VERB
ijpds-4459	230	22	cancer	cancer	NOUN
ijpds-4459	230	23	treatment	treatment	NOUN
ijpds-4459	230	24	.	.	PUNCT
ijpds-4459	231	1	nevertheless	nevertheless	ADV
ijpds-4459	231	2	,	,	PUNCT
ijpds-4459	231	3	unravelling	unravel	VERB
ijpds-4459	231	4	the	the	DET
ijpds-4459	231	5	intricacies	intricacy	NOUN
ijpds-4459	231	6	of	of	ADP
ijpds-4459	231	7	optimal	optimal	ADJ
ijpds-4459	231	8	combinations	combination	NOUN
ijpds-4459	231	9	and	and	CCONJ
ijpds-4459	231	10	understanding	understand	VERB
ijpds-4459	231	11	potential	potential	ADJ
ijpds-4459	231	12	interactions	interaction	NOUN
ijpds-4459	231	13	between	between	ADP
ijpds-4459	231	14	various	various	ADJ
ijpds-4459	231	15	biomaterials	biomaterial	NOUN
ijpds-4459	231	16	and	and	CCONJ
ijpds-4459	231	17	therapies	therapy	NOUN
ijpds-4459	231	18	poses	pose	VERB
ijpds-4459	231	19	a	a	DET
ijpds-4459	231	20	multifaceted	multifaceted	ADJ
ijpds-4459	231	21	scientific	scientific	ADJ
ijpds-4459	231	22	challenge	challenge	NOUN
ijpds-4459	231	23	that	that	PRON
ijpds-4459	231	24	demands	demand	VERB
ijpds-4459	231	25	meticulous	meticulous	ADJ
ijpds-4459	231	26	exploration	exploration	NOUN
ijpds-4459	231	27	[	[	PUNCT
ijpds-4459	231	28	64	64	NUM
ijpds-4459	231	29	-	-	SYM
ijpds-4459	231	30	66	66	NUM
ijpds-4459	231	31	]	]	PUNCT
ijpds-4459	231	32	.	.	PUNCT
ijpds-4459	232	1	lastly	lastly	ADV
ijpds-4459	232	2	,	,	PUNCT
ijpds-4459	232	3	as	as	ADP
ijpds-4459	232	4	biomaterial	biomaterial	ADJ
ijpds-4459	232	5	-	-	PUNCT
ijpds-4459	232	6	based	base	VERB
ijpds-4459	232	7	therapies	therapy	NOUN
ijpds-4459	232	8	transition	transition	NOUN
ijpds-4459	232	9	from	from	ADP
ijpds-4459	232	10	the	the	DET
ijpds-4459	232	11	realm	realm	NOUN
ijpds-4459	232	12	of	of	ADP
ijpds-4459	232	13	research	research	NOUN
ijpds-4459	232	14	to	to	ADP
ijpds-4459	232	15	clinical	clinical	ADJ
ijpds-4459	232	16	trials	trial	NOUN
ijpds-4459	232	17	,	,	PUNCT
ijpds-4459	232	18	successfully	successfully	ADV
ijpds-4459	232	19	navigating	navigate	VERB
ijpds-4459	232	20	the	the	DET
ijpds-4459	232	21	complex	complex	ADJ
ijpds-4459	232	22	regulatory	regulatory	ADJ
ijpds-4459	232	23	landscape	landscape	NOUN
ijpds-4459	232	24	and	and	CCONJ
ijpds-4459	232	25	securing	secure	VERB
ijpds-4459	232	26	approvals	approval	NOUN
ijpds-4459	232	27	from	from	ADP
ijpds-4459	232	28	regulatory	regulatory	ADJ
ijpds-4459	232	29	agencies	agency	NOUN
ijpds-4459	232	30	emerges	emerge	VERB
ijpds-4459	232	31	as	as	ADP
ijpds-4459	232	32	a	a	DET
ijpds-4459	232	33	pivotal	pivotal	ADJ
ijpds-4459	232	34	step	step	NOUN
ijpds-4459	232	35	[	[	X
ijpds-4459	232	36	64	64	NUM
ijpds-4459	232	37	]	]	PUNCT
ijpds-4459	232	38	.	.	PUNCT
ijpds-4459	233	1	this	this	PRON
ijpds-4459	233	2	necessitates	necessitate	VERB
ijpds-4459	233	3	collaborative	collaborative	ADJ
ijpds-4459	233	4	efforts	effort	NOUN
ijpds-4459	233	5	encompassing	encompass	VERB
ijpds-4459	233	6	academic	academic	ADJ
ijpds-4459	233	7	researchers	researcher	NOUN
ijpds-4459	233	8	,	,	PUNCT
ijpds-4459	233	9	industry	industry	NOUN
ijpds-4459	233	10	partners	partner	NOUN
ijpds-4459	233	11	,	,	PUNCT
ijpds-4459	233	12	and	and	CCONJ
ijpds-4459	233	13	regulatory	regulatory	ADJ
ijpds-4459	233	14	authorities	authority	NOUN
ijpds-4459	233	15	to	to	PART
ijpds-4459	233	16	ensure	ensure	VERB
ijpds-4459	233	17	the	the	DET
ijpds-4459	233	18	safe	safe	ADJ
ijpds-4459	233	19	and	and	CCONJ
ijpds-4459	233	20	efficient	efficient	ADJ
ijpds-4459	233	21	translation	translation	NOUN
ijpds-4459	233	22	of	of	ADP
ijpds-4459	233	23	these	these	DET
ijpds-4459	233	24	pioneering	pioneer	VERB
ijpds-4459	233	25	therapies	therapy	NOUN
ijpds-4459	233	26	into	into	ADP
ijpds-4459	233	27	clinical	clinical	ADJ
ijpds-4459	233	28	practice	practice	NOUN
ijpds-4459	234	1	[	[	X
ijpds-4459	234	2	64,65	64,65	NOUN
ijpds-4459	234	3	]	]	PUNCT
ijpds-4459	234	4	.	.	PUNCT
ijpds-4459	235	1	conclusion	conclusion	VERB
ijpds-4459	235	2	the	the	DET
ijpds-4459	235	3	combination	combination	NOUN
ijpds-4459	235	4	of	of	ADP
ijpds-4459	235	5	biomaterials	biomaterial	NOUN
ijpds-4459	235	6	and	and	CCONJ
ijpds-4459	235	7	breakthrough	breakthrough	NOUN
ijpds-4459	235	8	approaches	approach	NOUN
ijpds-4459	235	9	such	such	ADJ
ijpds-4459	235	10	as	as	ADP
ijpds-4459	235	11	cancer	cancer	NOUN
ijpds-4459	235	12	immunotherapy	immunotherapy	NOUN
ijpds-4459	235	13	and	and	CCONJ
ijpds-4459	235	14	genome	genome	NOUN
ijpds-4459	235	15	editing	editing	NOUN
ijpds-4459	235	16	are	be	AUX
ijpds-4459	235	17	ushering	usher	VERB
ijpds-4459	235	18	cancer	cancer	NOUN
ijpds-4459	235	19	treatment	treatment	NOUN
ijpds-4459	235	20	into	into	ADP
ijpds-4459	235	21	a	a	DET
ijpds-4459	235	22	new	new	ADJ
ijpds-4459	235	23	era	era	NOUN
ijpds-4459	235	24	.	.	PUNCT
ijpds-4459	236	1	biomaterials	biomaterial	NOUN
ijpds-4459	236	2	,	,	PUNCT
ijpds-4459	236	3	which	which	PRON
ijpds-4459	236	4	serve	serve	VERB
ijpds-4459	236	5	as	as	ADP
ijpds-4459	236	6	precision	precision	NOUN
ijpds-4459	236	7	transporters	transporter	NOUN
ijpds-4459	236	8	for	for	ADP
ijpds-4459	236	9	immune	immune	NOUN
ijpds-4459	236	10	-	-	PUNCT
ijpds-4459	236	11	modulating	modulate	VERB
ijpds-4459	236	12	drugs	drug	NOUN
ijpds-4459	236	13	,	,	PUNCT
ijpds-4459	236	14	are	be	AUX
ijpds-4459	236	15	meticulously	meticulously	ADV
ijpds-4459	236	16	engineered	engineer	VERB
ijpds-4459	236	17	to	to	PART
ijpds-4459	236	18	negotiate	negotiate	VERB
ijpds-4459	236	19	the	the	DET
ijpds-4459	236	20	complicated	complicated	ADJ
ijpds-4459	236	21	tumor	tumor	NOUN
ijpds-4459	236	22	microenvironment	microenvironment	NOUN
ijpds-4459	236	23	.	.	PUNCT
ijpds-4459	237	1	their	their	PRON
ijpds-4459	237	2	goal	goal	NOUN
ijpds-4459	237	3	,	,	PUNCT
ijpds-4459	237	4	like	like	ADP
ijpds-4459	237	5	that	that	PRON
ijpds-4459	237	6	of	of	ADP
ijpds-4459	237	7	architects	architect	NOUN
ijpds-4459	237	8	,	,	PUNCT
ijpds-4459	237	9	is	be	AUX
ijpds-4459	237	10	to	to	PART
ijpds-4459	237	11	encapsulate	encapsulate	VERB
ijpds-4459	237	12	and	and	CCONJ
ijpds-4459	237	13	distribute	distribute	VERB
ijpds-4459	237	14	therapeutic	therapeutic	ADJ
ijpds-4459	237	15	substances	substance	NOUN
ijpds-4459	237	16	,	,	PUNCT
ijpds-4459	237	17	thereby	thereby	ADV
ijpds-4459	237	18	boosting	boost	VERB
ijpds-4459	237	19	the	the	DET
ijpds-4459	237	20	body	body	NOUN
ijpds-4459	237	21	's	's	PART
ijpds-4459	237	22	immunological	immunological	ADJ
ijpds-4459	237	23	response	response	NOUN
ijpds-4459	237	24	to	to	ADP
ijpds-4459	237	25	cancer	cancer	NOUN
ijpds-4459	237	26	with	with	ADP
ijpds-4459	237	27	precise	precise	ADJ
ijpds-4459	237	28	targeting	targeting	NOUN
ijpds-4459	237	29	.	.	PUNCT
ijpds-4459	238	1	this	this	DET
ijpds-4459	238	2	formulation	formulation	NOUN
ijpds-4459	238	3	ensures	ensure	VERB
ijpds-4459	238	4	prolonged	prolonged	ADJ
ijpds-4459	238	5	release	release	NOUN
ijpds-4459	238	6	for	for	ADP
ijpds-4459	238	7	optimal	optimal	ADJ
ijpds-4459	238	8	treatment	treatment	NOUN
ijpds-4459	238	9	outcomes	outcome	NOUN
ijpds-4459	238	10	while	while	SCONJ
ijpds-4459	238	11	also	also	ADV
ijpds-4459	238	12	reducing	reduce	VERB
ijpds-4459	238	13	systemic	systemic	ADJ
ijpds-4459	238	14	toxicity	toxicity	NOUN
ijpds-4459	238	15	.	.	PUNCT
ijpds-4459	239	1	despite	despite	SCONJ
ijpds-4459	239	2	these	these	DET
ijpds-4459	239	3	advances	advance	NOUN
ijpds-4459	239	4	,	,	PUNCT
ijpds-4459	239	5	obstacles	obstacle	NOUN
ijpds-4459	239	6	remain	remain	VERB
ijpds-4459	239	7	,	,	PUNCT
ijpds-4459	239	8	particularly	particularly	ADV
ijpds-4459	239	9	in	in	ADP
ijpds-4459	239	10	biocompatibility	biocompatibility	NOUN
ijpds-4459	239	11	and	and	CCONJ
ijpds-4459	239	12	delivery	delivery	NOUN
ijpds-4459	239	13	efficiency	efficiency	NOUN
ijpds-4459	239	14	.	.	PUNCT
ijpds-4459	240	1	researchers	researcher	NOUN
ijpds-4459	240	2	are	be	AUX
ijpds-4459	240	3	actively	actively	ADV
ijpds-4459	240	4	overcoming	overcome	VERB
ijpds-4459	240	5	these	these	DET
ijpds-4459	240	6	barriers	barrier	NOUN
ijpds-4459	240	7	in	in	ADP
ijpds-4459	240	8	order	order	NOUN
ijpds-4459	240	9	to	to	PART
ijpds-4459	240	10	fully	fully	ADV
ijpds-4459	240	11	realize	realize	VERB
ijpds-4459	240	12	the	the	DET
ijpds-4459	240	13	revolutionary	revolutionary	ADJ
ijpds-4459	240	14	promise	promise	NOUN
ijpds-4459	240	15	of	of	ADP
ijpds-4459	240	16	biomaterials	biomaterial	NOUN
ijpds-4459	240	17	,	,	PUNCT
ijpds-4459	240	18	recognizing	recognize	VERB
ijpds-4459	240	19	the	the	DET
ijpds-4459	240	20	need	need	NOUN
ijpds-4459	240	21	of	of	ADP
ijpds-4459	240	22	tailoring	tailor	VERB
ijpds-4459	240	23	treatments	treatment	NOUN
ijpds-4459	240	24	to	to	ADP
ijpds-4459	240	25	individual	individual	ADJ
ijpds-4459	240	26	genetic	genetic	ADJ
ijpds-4459	240	27	profiles	profile	NOUN
ijpds-4459	240	28	for	for	ADP
ijpds-4459	240	29	personalized	personalized	ADJ
ijpds-4459	240	30	medicine	medicine	NOUN
ijpds-4459	240	31	.	.	PUNCT
ijpds-4459	241	1	global	global	ADJ
ijpds-4459	241	2	impact	impact	NOUN
ijpds-4459	241	3	cancer	cancer	NOUN
ijpds-4459	241	4	care	care	NOUN
ijpds-4459	241	5	could	could	AUX
ijpds-4459	241	6	be	be	AUX
ijpds-4459	241	7	safer	safe	ADJ
ijpds-4459	241	8	and	and	CCONJ
ijpds-4459	241	9	more	more	ADV
ijpds-4459	241	10	effective	effective	ADJ
ijpds-4459	241	11	with	with	ADP
ijpds-4459	241	12	this	this	DET
ijpds-4459	241	13	individualized	individualized	ADJ
ijpds-4459	241	14	approach	approach	NOUN
ijpds-4459	241	15	.	.	PUNCT
ijpds-4459	242	1	a	a	DET
ijpds-4459	242	2	thorough	thorough	ADJ
ijpds-4459	242	3	understanding	understanding	NOUN
ijpds-4459	242	4	of	of	ADP
ijpds-4459	242	5	the	the	DET
ijpds-4459	242	6	transformative	transformative	ADJ
ijpds-4459	242	7	role	role	NOUN
ijpds-4459	242	8	that	that	SCONJ
ijpds-4459	242	9	biomaterials	biomaterial	NOUN
ijpds-4459	242	10	will	will	AUX
ijpds-4459	242	11	play	play	VERB
ijpds-4459	242	12	in	in	ADP
ijpds-4459	242	13	reshaping	reshape	VERB
ijpds-4459	242	14	cancer	cancer	NOUN
ijpds-4459	242	15	care	care	NOUN
ijpds-4459	242	16	in	in	ADP
ijpds-4459	242	17	the	the	DET
ijpds-4459	242	18	future	future	NOUN
ijpds-4459	242	19	and	and	CCONJ
ijpds-4459	242	20	fostering	foster	VERB
ijpds-4459	242	21	innovation	innovation	NOUN
ijpds-4459	242	22	towards	towards	ADP
ijpds-4459	242	23	safer	safe	ADJ
ijpds-4459	242	24	,	,	PUNCT
ijpds-4459	242	25	more	more	ADV
ijpds-4459	242	26	effective	effective	ADJ
ijpds-4459	242	27	,	,	PUNCT
ijpds-4459	242	28	and	and	CCONJ
ijpds-4459	242	29	personalized	personalized	ADJ
ijpds-4459	242	30	treatment	treatment	NOUN
ijpds-4459	242	31	avenues	avenue	NOUN
ijpds-4459	242	32	can	can	AUX
ijpds-4459	242	33	be	be	AUX
ijpds-4459	242	34	gained	gain	VERB
ijpds-4459	242	35	by	by	ADP
ijpds-4459	242	36	critically	critically	ADV
ijpds-4459	242	37	evaluating	evaluate	VERB
ijpds-4459	242	38	the	the	DET
ijpds-4459	242	39	current	current	ADJ
ijpds-4459	242	40	landscape	landscape	NOUN
ijpds-4459	242	41	,	,	PUNCT
ijpds-4459	242	42	acknowledging	acknowledge	VERB
ijpds-4459	242	43	its	its	PRON
ijpds-4459	242	44	limitations	limitation	NOUN
ijpds-4459	242	45	and	and	CCONJ
ijpds-4459	242	46	ongoing	ongoing	ADJ
ijpds-4459	242	47	challenges	challenge	NOUN
ijpds-4459	242	48	,	,	PUNCT
ijpds-4459	242	49	and	and	CCONJ
ijpds-4459	242	50	combining	combine	VERB
ijpds-4459	242	51	it	it	PRON
ijpds-4459	242	52	with	with	ADP
ijpds-4459	242	53	insights	insight	NOUN
ijpds-4459	242	54	into	into	ADP
ijpds-4459	242	55	cutting	cut	VERB
ijpds-4459	242	56	-	-	PUNCT
ijpds-4459	242	57	edge	edge	NOUN
ijpds-4459	242	58	research	research	NOUN
ijpds-4459	242	59	.	.	PUNCT
ijpds-4459	243	1	references	reference	NOUN
ijpds-4459	243	2	1	1	NUM
ijpds-4459	243	3	.	.	PUNCT
ijpds-4459	244	1	hanahan	hanahan	PROPN
ijpds-4459	244	2	d	d	PROPN
ijpds-4459	244	3	,	,	PUNCT
ijpds-4459	244	4	weinberg	weinberg	PROPN
ijpds-4459	244	5	ra	ra	PROPN
ijpds-4459	244	6	.	.	PUNCT
ijpds-4459	245	1	hallmarks	hallmark	NOUN
ijpds-4459	245	2	of	of	ADP
ijpds-4459	245	3	cancer	cancer	NOUN
ijpds-4459	245	4	:	:	PUNCT
ijpds-4459	245	5	the	the	DET
ijpds-4459	245	6	next	next	ADJ
ijpds-4459	245	7	generation	generation	NOUN
ijpds-4459	245	8	.	.	PUNCT
ijpds-4459	246	1	cell	cell	NOUN
ijpds-4459	246	2	.	.	PUNCT
ijpds-4459	247	1	2011	2011	NUM
ijpds-4459	247	2	;	;	PUNCT
ijpds-4459	247	3	144(5):646	144(5):646	NUM
ijpds-4459	247	4	-	-	SYM
ijpds-4459	247	5	74	74	NUM
ijpds-4459	247	6	.	.	NOUN
ijpds-4459	248	1	2	2	X
ijpds-4459	248	2	.	.	X
ijpds-4459	248	3	miller	miller	PROPN
ijpds-4459	248	4	kd	kd	PROPN
ijpds-4459	248	5	,	,	PUNCT
ijpds-4459	248	6	nogueira	nogueira	PROPN
ijpds-4459	248	7	l	l	PROPN
ijpds-4459	248	8	,	,	PUNCT
ijpds-4459	248	9	mariotto	mariotto	PROPN
ijpds-4459	249	1	ab	ab	PROPN
ijpds-4459	249	2	,	,	PUNCT
ijpds-4459	249	3	et	et	PROPN
ijpds-4459	249	4	al	al	PROPN
ijpds-4459	249	5	.	.	PUNCT
ijpds-4459	249	6	cancer	cancer	NOUN
ijpds-4459	249	7	treatment	treatment	NOUN
ijpds-4459	249	8	and	and	CCONJ
ijpds-4459	249	9	survivorship	survivorship	NOUN
ijpds-4459	249	10	statistics	statistic	NOUN
ijpds-4459	249	11	.	.	PUNCT
ijpds-4459	250	1	ca	can	AUX
ijpds-4459	250	2	cancer	cancer	PROPN
ijpds-4459	250	3	j	j	PROPN
ijpds-4459	250	4	clin	clin	PROPN
ijpds-4459	250	5	.	.	PUNCT
ijpds-4459	251	1	2019	2019	NUM
ijpds-4459	251	2	;	;	PUNCT
ijpds-4459	251	3	69(5):363	69(5):363	NUM
ijpds-4459	251	4	-	-	SYM
ijpds-4459	251	5	85	85	NUM
ijpds-4459	251	6	.	.	PUNCT
ijpds-4459	252	1	3	3	X
ijpds-4459	252	2	.	.	X
ijpds-4459	253	1	sharma	sharma	PROPN
ijpds-4459	253	2	p	p	PROPN
ijpds-4459	253	3	,	,	PUNCT
ijpds-4459	253	4	allison	allison	PROPN
ijpds-4459	253	5	jp	jp	PROPN
ijpds-4459	253	6	.	.	PROPN
ijpds-4459	253	7	immune	immune	ADJ
ijpds-4459	253	8	checkpoint	checkpoint	NOUN
ijpds-4459	253	9	targeting	target	VERB
ijpds-4459	253	10	in	in	ADP
ijpds-4459	253	11	cancer	cancer	NOUN
ijpds-4459	253	12	therapy	therapy	NOUN
ijpds-4459	253	13	:	:	PUNCT
ijpds-4459	253	14	toward	toward	ADP
ijpds-4459	253	15	combination	combination	NOUN
ijpds-4459	253	16	strategies	strategy	NOUN
ijpds-4459	253	17	with	with	ADP
ijpds-4459	253	18	curative	curative	ADJ
ijpds-4459	253	19	potential	potential	NOUN
ijpds-4459	253	20	.	.	PUNCT
ijpds-4459	254	1	cell	cell	NOUN
ijpds-4459	254	2	.	.	PUNCT
ijpds-4459	255	1	2015	2015	NUM
ijpds-4459	255	2	;	;	PUNCT
ijpds-4459	255	3	161(2):205	161(2):205	NUM
ijpds-4459	255	4	-	-	SYM
ijpds-4459	255	5	14	14	NUM
ijpds-4459	255	6	.	.	PUNCT
ijpds-4459	256	1	4	4	X
ijpds-4459	256	2	.	.	X
ijpds-4459	256	3	mellman	mellman	PROPN
ijpds-4459	256	4	i	i	PRON
ijpds-4459	256	5	,	,	PUNCT
ijpds-4459	256	6	coukos	coukos	NOUN
ijpds-4459	256	7	g	g	NOUN
ijpds-4459	256	8	,	,	PUNCT
ijpds-4459	256	9	dranoff	dranoff	PROPN
ijpds-4459	256	10	g.	g.	PROPN
ijpds-4459	256	11	cancer	cancer	PROPN
ijpds-4459	256	12	immunotherapy	immunotherapy	NOUN
ijpds-4459	256	13	comes	come	VERB
ijpds-4459	256	14	of	of	ADP
ijpds-4459	256	15	age	age	NOUN
ijpds-4459	256	16	.	.	PUNCT
ijpds-4459	257	1	nature	nature	NOUN
ijpds-4459	257	2	.	.	PUNCT
ijpds-4459	258	1	2011	2011	NUM
ijpds-4459	258	2	;	;	PUNCT
ijpds-4459	258	3	480(7378):480	480(7378):480	NOUN
ijpds-4459	258	4	-	-	SYM
ijpds-4459	258	5	9	9	NUM
ijpds-4459	258	6	.	.	NOUN
ijpds-4459	258	7	5	5	NUM
ijpds-4459	258	8	.	.	X
ijpds-4459	259	1	jinek	jinek	PROPN
ijpds-4459	259	2	m	m	PROPN
ijpds-4459	259	3	,	,	PUNCT
ijpds-4459	259	4	chylinski	chylinski	PROPN
ijpds-4459	259	5	k	k	PROPN
ijpds-4459	259	6	,	,	PUNCT
ijpds-4459	259	7	fonfara	fonfara	PROPN
ijpds-4459	259	8	i	i	PRON
ijpds-4459	259	9	,	,	PUNCT
ijpds-4459	259	10	et	et	PROPN
ijpds-4459	259	11	al	al	PROPN
ijpds-4459	259	12	.	.	PUNCT
ijpds-4459	260	1	a	a	DET
ijpds-4459	260	2	programmable	programmable	ADJ
ijpds-4459	260	3	dualrna	dualrna	NOUN
ijpds-4459	260	4	-	-	PUNCT
ijpds-4459	260	5	guided	guide	VERB
ijpds-4459	260	6	dna	dna	NOUN
ijpds-4459	260	7	endonuclease	endonuclease	NOUN
ijpds-4459	260	8	in	in	ADP
ijpds-4459	260	9	adaptive	adaptive	ADJ
ijpds-4459	260	10	bacterial	bacterial	ADJ
ijpds-4459	260	11	immunity	immunity	NOUN
ijpds-4459	260	12	.	.	PUNCT
ijpds-4459	261	1	science	science	NOUN
ijpds-4459	261	2	.	.	PUNCT
ijpds-4459	262	1	2012	2012	NUM
ijpds-4459	262	2	;	;	PUNCT
ijpds-4459	262	3	337(6096):816	337(6096):816	NUM
ijpds-4459	262	4	-	-	SYM
ijpds-4459	262	5	21	21	NUM
ijpds-4459	262	6	.	.	PUNCT
ijpds-4459	263	1	6	6	NUM
ijpds-4459	263	2	.	.	X
ijpds-4459	263	3	topalian	topalian	PROPN
ijpds-4459	263	4	sl	sl	PROPN
ijpds-4459	263	5	,	,	PUNCT
ijpds-4459	263	6	drake	drake	PROPN
ijpds-4459	263	7	cg	cg	PROPN
ijpds-4459	263	8	,	,	PUNCT
ijpds-4459	263	9	pardoll	pardoll	PROPN
ijpds-4459	263	10	dm	dm	PROPN
ijpds-4459	263	11	.	.	PROPN
ijpds-4459	263	12	immune	immune	ADJ
ijpds-4459	263	13	checkpoint	checkpoint	NOUN
ijpds-4459	263	14	blockade	blockade	NOUN
ijpds-4459	263	15	:	:	PUNCT
ijpds-4459	263	16	a	a	DET
ijpds-4459	263	17	common	common	ADJ
ijpds-4459	263	18	denominator	denominator	NOUN
ijpds-4459	263	19	approach	approach	NOUN
ijpds-4459	263	20	to	to	ADP
ijpds-4459	263	21	cancer	cancer	NOUN
ijpds-4459	263	22	therapy	therapy	NOUN
ijpds-4459	263	23	.	.	PUNCT
ijpds-4459	264	1	cancer	cancer	NOUN
ijpds-4459	264	2	cell	cell	NOUN
ijpds-4459	264	3	.	.	PUNCT
ijpds-4459	265	1	2015	2015	NUM
ijpds-4459	265	2	;	;	PUNCT
ijpds-4459	265	3	27(4):450	27(4):450	NUM
ijpds-4459	265	4	-	-	SYM
ijpds-4459	265	5	61	61	NUM
ijpds-4459	265	6	.	.	PUNCT
ijpds-4459	266	1	7	7	X
ijpds-4459	266	2	.	.	PUNCT
ijpds-4459	266	3	brahmer	brahmer	PROPN
ijpds-4459	266	4	jr	jr	PROPN
ijpds-4459	266	5	,	,	PUNCT
ijpds-4459	266	6	tykodi	tykodi	PROPN
ijpds-4459	266	7	ss	ss	PROPN
ijpds-4459	266	8	,	,	PUNCT
ijpds-4459	266	9	chow	chow	PROPN
ijpds-4459	266	10	lq	lq	PROPN
ijpds-4459	266	11	,	,	PUNCT
ijpds-4459	266	12	et	et	PROPN
ijpds-4459	266	13	al	al	PROPN
ijpds-4459	266	14	.	.	PROPN
ijpds-4459	266	15	safety	safety	NOUN
ijpds-4459	266	16	and	and	CCONJ
ijpds-4459	266	17	activity	activity	NOUN
ijpds-4459	266	18	of	of	ADP
ijpds-4459	266	19	anti	anti	ADJ
ijpds-4459	266	20	-	-	ADJ
ijpds-4459	266	21	pd	pd	ADJ
ijpds-4459	266	22	-	-	PUNCT
ijpds-4459	266	23	l1	l1	PROPN
ijpds-4459	266	24	antibody	antibody	NOUN
ijpds-4459	266	25	in	in	ADP
ijpds-4459	266	26	patients	patient	NOUN
ijpds-4459	266	27	with	with	ADP
ijpds-4459	266	28	advanced	advanced	ADJ
ijpds-4459	266	29	cancer	cancer	NOUN
ijpds-4459	266	30	.	.	PUNCT
ijpds-4459	267	1	n	n	PROPN
ijpds-4459	267	2	engl	engl	PROPN
ijpds-4459	267	3	j	j	PROPN
ijpds-4459	267	4	med	med	PROPN
ijpds-4459	267	5	.	.	PROPN
ijpds-4459	267	6	2012	2012	NUM
ijpds-4459	267	7	;	;	PUNCT
ijpds-4459	267	8	366(26):2455	366(26):2455	PROPN
ijpds-4459	267	9	-	-	PUNCT
ijpds-4459	267	10	65	65	NUM
ijpds-4459	267	11	.	.	NOUN
ijpds-4459	267	12	8	8	NUM
ijpds-4459	267	13	.	.	X
ijpds-4459	268	1	porter	porter	PROPN
ijpds-4459	268	2	dl	dl	PROPN
ijpds-4459	268	3	,	,	PUNCT
ijpds-4459	268	4	levine	levine	PROPN
ijpds-4459	268	5	bl	bl	PROPN
ijpds-4459	268	6	,	,	PUNCT
ijpds-4459	268	7	kalos	kalos	PROPN
ijpds-4459	268	8	m	m	PROPN
ijpds-4459	268	9	,	,	PUNCT
ijpds-4459	268	10	et	et	PROPN
ijpds-4459	268	11	al	al	PROPN
ijpds-4459	268	12	.	.	PROPN
ijpds-4459	268	13	chimeric	chimeric	ADJ
ijpds-4459	268	14	antigen	antigen	PROPN
ijpds-4459	268	15	receptormodified	receptormodifie	VERB
ijpds-4459	268	16	t	t	NOUN
ijpds-4459	268	17	cells	cell	NOUN
ijpds-4459	268	18	in	in	ADP
ijpds-4459	268	19	chronic	chronic	ADJ
ijpds-4459	268	20	lymphoid	lymphoid	NOUN
ijpds-4459	268	21	leukemia	leukemia	NOUN
ijpds-4459	268	22	.	.	PUNCT
ijpds-4459	269	1	n	n	CCONJ
ijpds-4459	269	2	engl	engl	PROPN
ijpds-4459	269	3	j	j	PROPN
ijpds-4459	269	4	med	med	PROPN
ijpds-4459	269	5	.	.	PUNCT
ijpds-4459	269	6	2011	2011	NUM
ijpds-4459	269	7	;	;	PUNCT
ijpds-4459	269	8	365(8):725	365(8):725	NUM
ijpds-4459	269	9	-	-	SYM
ijpds-4459	269	10	33	33	NUM
ijpds-4459	269	11	.	.	NOUN
ijpds-4459	270	1	9	9	NUM
ijpds-4459	270	2	.	.	PUNCT
ijpds-4459	270	3	sahin	sahin	PROPN
ijpds-4459	270	4	u	u	PROPN
ijpds-4459	270	5	,	,	PUNCT
ijpds-4459	270	6	derhovanessian	derhovanessian	PROPN
ijpds-4459	270	7	e	e	PROPN
ijpds-4459	270	8	,	,	PUNCT
ijpds-4459	270	9	miller	miller	PROPN
ijpds-4459	270	10	m	m	PROPN
ijpds-4459	270	11	,	,	PUNCT
ijpds-4459	270	12	et	et	PROPN
ijpds-4459	270	13	al	al	PROPN
ijpds-4459	270	14	.	.	PROPN
ijpds-4459	270	15	personalized	personalize	VERB
ijpds-4459	270	16	rna	rna	PROPN
ijpds-4459	270	17	mutanome	mutanome	NOUN
ijpds-4459	270	18	vaccines	vaccine	NOUN
ijpds-4459	270	19	mobilize	mobilize	VERB
ijpds-4459	270	20	poly	poly	ADJ
ijpds-4459	270	21	-	-	PUNCT
ijpds-4459	270	22	specific	specific	ADJ
ijpds-4459	270	23	therapeutic	therapeutic	ADJ
ijpds-4459	270	24	immunity	immunity	NOUN
ijpds-4459	270	25	against	against	ADP
ijpds-4459	270	26	cancer	cancer	NOUN
ijpds-4459	270	27	.	.	PUNCT
ijpds-4459	271	1	nature	nature	NOUN
ijpds-4459	271	2	.	.	PUNCT
ijpds-4459	272	1	2017	2017	NUM
ijpds-4459	272	2	;	;	PUNCT
ijpds-4459	272	3	547(7662):222	547(7662):222	NUM
ijpds-4459	272	4	-	-	SYM
ijpds-4459	272	5	6	6	NUM
ijpds-4459	272	6	.	.	NOUN
ijpds-4459	272	7	10	10	NUM
ijpds-4459	272	8	.	.	PUNCT
ijpds-4459	273	1	vinay	vinay	PROPN
ijpds-4459	273	2	ds	ds	PROPN
ijpds-4459	273	3	,	,	PUNCT
ijpds-4459	273	4	ryan	ryan	PROPN
ijpds-4459	273	5	ep	ep	PROPN
ijpds-4459	273	6	,	,	PUNCT
ijpds-4459	273	7	pawelec	pawelec	NOUN
ijpds-4459	273	8	g	g	NOUN
ijpds-4459	273	9	,	,	PUNCT
ijpds-4459	273	10	et	et	PROPN
ijpds-4459	273	11	al	al	PROPN
ijpds-4459	273	12	.	.	PROPN
ijpds-4459	273	13	immune	immune	ADJ
ijpds-4459	273	14	evasion	evasion	NOUN
ijpds-4459	273	15	in	in	ADP
ijpds-4459	273	16	cancer	cancer	NOUN
ijpds-4459	273	17	:	:	PUNCT
ijpds-4459	273	18	mechanistic	mechanistic	ADJ
ijpds-4459	273	19	basis	basis	NOUN
ijpds-4459	273	20	and	and	CCONJ
ijpds-4459	273	21	therapeutic	therapeutic	ADJ
ijpds-4459	273	22	strategies	strategy	NOUN
ijpds-4459	273	23	.	.	PUNCT
ijpds-4459	274	1	semin	semin	PROPN
ijpds-4459	274	2	cancer	cancer	PROPN
ijpds-4459	274	3	biol	biol	PROPN
ijpds-4459	274	4	.	.	PUNCT
ijpds-4459	275	1	2015	2015	NUM
ijpds-4459	275	2	;	;	PUNCT
ijpds-4459	275	3	35	35	NUM
ijpds-4459	275	4	:	:	PUNCT
ijpds-4459	275	5	s185	s185	PROPN
ijpds-4459	275	6	-	-	PUNCT
ijpds-4459	275	7	s198	s198	PROPN
ijpds-4459	275	8	.	.	PROPN
ijpds-4459	276	1	11	11	NUM
ijpds-4459	276	2	.	.	PUNCT
ijpds-4459	277	1	burrell	burrell	PROPN
ijpds-4459	277	2	ra	ra	PROPN
ijpds-4459	277	3	,	,	PUNCT
ijpds-4459	277	4	mcgranahan	mcgranahan	PROPN
ijpds-4459	277	5	n	n	PROPN
ijpds-4459	277	6	,	,	PUNCT
ijpds-4459	277	7	bartek	bartek	PROPN
ijpds-4459	277	8	j	j	PROPN
ijpds-4459	277	9	,	,	PUNCT
ijpds-4459	277	10	et	et	PROPN
ijpds-4459	277	11	al	al	PROPN
ijpds-4459	277	12	.	.	PUNCT
ijpds-4459	278	1	the	the	DET
ijpds-4459	278	2	causes	cause	NOUN
ijpds-4459	278	3	and	and	CCONJ
ijpds-4459	278	4	consequences	consequence	NOUN
ijpds-4459	278	5	of	of	ADP
ijpds-4459	278	6	genetic	genetic	ADJ
ijpds-4459	278	7	heterogeneity	heterogeneity	NOUN
ijpds-4459	278	8	in	in	ADP
ijpds-4459	278	9	cancer	cancer	NOUN
ijpds-4459	278	10	evolution	evolution	NOUN
ijpds-4459	278	11	.	.	PUNCT
ijpds-4459	279	1	nature	nature	NOUN
ijpds-4459	279	2	.	.	PUNCT
ijpds-4459	280	1	2013	2013	NUM
ijpds-4459	280	2	;	;	PUNCT
ijpds-4459	280	3	501(7467):338	501(7467):338	NUM
ijpds-4459	280	4	-	-	SYM
ijpds-4459	280	5	45	45	NUM
ijpds-4459	280	6	.	.	NOUN
ijpds-4459	280	7	12	12	NUM
ijpds-4459	280	8	.	.	PUNCT
ijpds-4459	281	1	doudna	doudna	PROPN
ijpds-4459	281	2	ja	ja	PROPN
ijpds-4459	281	3	,	,	PUNCT
ijpds-4459	281	4	charpentier	charpentier	PROPN
ijpds-4459	281	5	e.	e.	PROPN
ijpds-4459	281	6	the	the	DET
ijpds-4459	281	7	new	new	ADJ
ijpds-4459	281	8	frontier	frontier	NOUN
ijpds-4459	281	9	of	of	ADP
ijpds-4459	281	10	genome	genome	NOUN
ijpds-4459	281	11	engineering	engineering	NOUN
ijpds-4459	281	12	with	with	ADP
ijpds-4459	281	13	crispr	crispr	NOUN
ijpds-4459	281	14	-	-	PUNCT
ijpds-4459	281	15	cas9	cas9	NOUN
ijpds-4459	281	16	.	.	PUNCT
ijpds-4459	282	1	science	science	NOUN
ijpds-4459	282	2	.	.	PUNCT
ijpds-4459	283	1	2014	2014	NUM
ijpds-4459	283	2	;	;	PUNCT
ijpds-4459	284	1	346(6213):1258096	346(6213):1258096	NUM
ijpds-4459	284	2	.	.	NOUN
ijpds-4459	285	1	13	13	NUM
ijpds-4459	285	2	.	.	PUNCT
ijpds-4459	285	3	hsu	hsu	PROPN
ijpds-4459	285	4	pd	pd	PROPN
ijpds-4459	285	5	,	,	PUNCT
ijpds-4459	285	6	lander	lander	PROPN
ijpds-4459	285	7	es	es	PROPN
ijpds-4459	285	8	,	,	PUNCT
ijpds-4459	285	9	zhang	zhang	PROPN
ijpds-4459	285	10	f.	f.	PROPN
ijpds-4459	285	11	development	development	PROPN
ijpds-4459	285	12	and	and	CCONJ
ijpds-4459	285	13	applications	application	NOUN
ijpds-4459	285	14	of	of	ADP
ijpds-4459	285	15	crispr	crispr	NOUN
ijpds-4459	285	16	-	-	PUNCT
ijpds-4459	285	17	cas9	cas9	NOUN
ijpds-4459	285	18	for	for	ADP
ijpds-4459	285	19	genome	genome	NOUN
ijpds-4459	285	20	engineering	engineering	NOUN
ijpds-4459	285	21	.	.	PUNCT
ijpds-4459	286	1	cell	cell	NOUN
ijpds-4459	286	2	.	.	PUNCT
ijpds-4459	287	1	2014	2014	NUM
ijpds-4459	287	2	;	;	PUNCT
ijpds-4459	287	3	157(6):1262	157(6):1262	NOUN
ijpds-4459	287	4	-	-	SYM
ijpds-4459	287	5	78	78	NUM
ijpds-4459	287	6	.	.	PUNCT
ijpds-4459	288	1	14	14	NUM
ijpds-4459	288	2	.	.	PUNCT
ijpds-4459	289	1	garraway	garraway	PROPN
ijpds-4459	289	2	la	la	PROPN
ijpds-4459	289	3	,	,	PUNCT
ijpds-4459	289	4	lander	lander	PROPN
ijpds-4459	289	5	es	es	NOUN
ijpds-4459	289	6	.	.	PUNCT
ijpds-4459	289	7	lessons	lesson	NOUN
ijpds-4459	289	8	from	from	ADP
ijpds-4459	289	9	the	the	DET
ijpds-4459	289	10	cancer	cancer	NOUN
ijpds-4459	289	11	genome	genome	NOUN
ijpds-4459	289	12	.	.	PUNCT
ijpds-4459	290	1	cell	cell	NOUN
ijpds-4459	290	2	.	.	PUNCT
ijpds-4459	291	1	2013	2013	NUM
ijpds-4459	291	2	;	;	PUNCT
ijpds-4459	291	3	153(1):17	153(1):17	NUM
ijpds-4459	291	4	-	-	SYM
ijpds-4459	291	5	37	37	NUM
ijpds-4459	291	6	.	.	NOUN
ijpds-4459	292	1	15	15	NUM
ijpds-4459	292	2	.	.	PUNCT
ijpds-4459	293	1	wilhelm	wilhelm	PROPN
ijpds-4459	293	2	s	s	PROPN
ijpds-4459	293	3	,	,	PUNCT
ijpds-4459	293	4	tavares	tavares	PROPN
ijpds-4459	293	5	aj	aj	PROPN
ijpds-4459	293	6	,	,	PUNCT
ijpds-4459	293	7	dai	dai	PROPN
ijpds-4459	293	8	q	q	PROPN
ijpds-4459	293	9	,	,	PUNCT
ijpds-4459	293	10	et	et	PROPN
ijpds-4459	293	11	al	al	PROPN
ijpds-4459	293	12	.	.	PUNCT
ijpds-4459	294	1	analysis	analysis	NOUN
ijpds-4459	294	2	of	of	ADP
ijpds-4459	294	3	nanoparticle	nanoparticle	NOUN
ijpds-4459	294	4	delivery	delivery	NOUN
ijpds-4459	294	5	to	to	ADP
ijpds-4459	294	6	tumours	tumours	PROPN
ijpds-4459	294	7	.	.	PUNCT
ijpds-4459	295	1	nat	nat	PROPN
ijpds-4459	295	2	rev	rev	PROPN
ijpds-4459	295	3	mater	mater	NOUN
ijpds-4459	295	4	.	.	PROPN
ijpds-4459	295	5	2016	2016	NUM
ijpds-4459	295	6	;	;	PUNCT
ijpds-4459	295	7	1:16014	1:16014	NUM
ijpds-4459	295	8	.	.	PROPN
ijpds-4459	296	1	16	16	NUM
ijpds-4459	296	2	.	.	PUNCT
ijpds-4459	297	1	hutmacher	hutmacher	PROPN
ijpds-4459	297	2	dw	dw	PROPN
ijpds-4459	297	3	,	,	PUNCT
ijpds-4459	297	4	schantz	schantz	PROPN
ijpds-4459	297	5	jt	jt	PROPN
ijpds-4459	297	6	,	,	PUNCT
ijpds-4459	297	7	lam	lam	PROPN
ijpds-4459	297	8	cx	cx	PROPN
ijpds-4459	297	9	,	,	PUNCT
ijpds-4459	297	10	et	et	PROPN
ijpds-4459	297	11	al	al	PROPN
ijpds-4459	297	12	.	.	PUNCT
ijpds-4459	298	1	state	state	NOUN
ijpds-4459	298	2	of	of	ADP
ijpds-4459	298	3	the	the	DET
ijpds-4459	298	4	art	art	NOUN
ijpds-4459	298	5	and	and	CCONJ
ijpds-4459	298	6	future	future	ADJ
ijpds-4459	298	7	directions	direction	NOUN
ijpds-4459	298	8	of	of	ADP
ijpds-4459	298	9	scaffold	scaffold	NOUN
ijpds-4459	298	10	-	-	PUNCT
ijpds-4459	298	11	based	base	VERB
ijpds-4459	298	12	bone	bone	NOUN
ijpds-4459	298	13	engineering	engineering	NOUN
ijpds-4459	298	14	from	from	ADP
ijpds-4459	298	15	a	a	DET
ijpds-4459	298	16	biomaterials	biomaterial	NOUN
ijpds-4459	298	17	perspective	perspective	NOUN
ijpds-4459	298	18	.	.	PUNCT
ijpds-4459	299	1	j	j	PROPN
ijpds-4459	299	2	tissue	tissue	NOUN
ijpds-4459	299	3	eng	eng	PROPN
ijpds-4459	299	4	regen	regen	PROPN
ijpds-4459	299	5	med	med	PROPN
ijpds-4459	299	6	.	.	PUNCT
ijpds-4459	299	7	2007	2007	NUM
ijpds-4459	299	8	;	;	PUNCT
ijpds-4459	299	9	1(4):245	1(4):245	NUM
ijpds-4459	299	10	-	-	SYM
ijpds-4459	299	11	60	60	NUM
ijpds-4459	299	12	.	.	PUNCT
ijpds-4459	299	13	17	17	NUM
ijpds-4459	299	14	.	.	PUNCT
ijpds-4459	300	1	stephan	stephan	PROPN
ijpds-4459	300	2	sb	sb	PROPN
ijpds-4459	300	3	,	,	PUNCT
ijpds-4459	300	4	taber	taber	PROPN
ijpds-4459	300	5	am	am	PROPN
ijpds-4459	300	6	,	,	PUNCT
ijpds-4459	300	7	jileaeva	jileaeva	PROPN
ijpds-4459	300	8	i	i	PRON
ijpds-4459	300	9	,	,	PUNCT
ijpds-4459	300	10	et	et	PROPN
ijpds-4459	300	11	al	al	PROPN
ijpds-4459	300	12	.	.	PUNCT
ijpds-4459	301	1	biopolymer	biopolymer	PROPN
ijpds-4459	301	2	implants	implant	NOUN
ijpds-4459	301	3	enhance	enhance	VERB
ijpds-4459	301	4	the	the	DET
ijpds-4459	301	5	efficacy	efficacy	NOUN
ijpds-4459	301	6	of	of	ADP
ijpds-4459	301	7	adoptive	adoptive	PROPN
ijpds-4459	301	8	t	t	PROPN
ijpds-4459	301	9	-	-	PUNCT
ijpds-4459	301	10	cell	cell	NOUN
ijpds-4459	301	11	therapy	therapy	NOUN
ijpds-4459	301	12	.	.	PUNCT
ijpds-4459	302	1	nat	nat	PROPN
ijpds-4459	302	2	biotechnol	biotechnol	NOUN
ijpds-4459	302	3	.	.	PUNCT
ijpds-4459	303	1	2015	2015	NUM
ijpds-4459	303	2	;	;	PUNCT
ijpds-4459	304	1	33(1):97	33(1):97	NUM
ijpds-4459	304	2	-	-	SYM
ijpds-4459	304	3	101	101	NUM
ijpds-4459	304	4	.	.	PUNCT
ijpds-4459	304	5	18	18	NUM
ijpds-4459	304	6	.	.	X
ijpds-4459	305	1	smith	smith	PROPN
ijpds-4459	305	2	tt	tt	PROPN
ijpds-4459	305	3	,	,	PUNCT
ijpds-4459	305	4	stephan	stephan	PROPN
ijpds-4459	305	5	sb	sb	PROPN
ijpds-4459	305	6	,	,	PUNCT
ijpds-4459	305	7	moffett	moffett	PROPN
ijpds-4459	305	8	hf	hf	PROPN
ijpds-4459	305	9	,	,	PUNCT
ijpds-4459	305	10	et	et	PROPN
ijpds-4459	305	11	al	al	PROPN
ijpds-4459	305	12	.	.	PROPN
ijpds-4459	306	1	in	in	ADP
ijpds-4459	306	2	situ	situ	ADJ
ijpds-4459	306	3	programming	programming	NOUN
ijpds-4459	306	4	of	of	ADP
ijpds-4459	306	5	leukaemia	leukaemia	NOUN
ijpds-4459	306	6	-	-	PUNCT
ijpds-4459	306	7	specific	specific	ADJ
ijpds-4459	306	8	t	t	NOUN
ijpds-4459	306	9	cells	cell	NOUN
ijpds-4459	306	10	using	use	VERB
ijpds-4459	306	11	synthetic	synthetic	ADJ
ijpds-4459	306	12	dna	dna	NOUN
ijpds-4459	306	13	nanocarriers	nanocarrier	NOUN
ijpds-4459	306	14	.	.	PUNCT
ijpds-4459	307	1	nat	nat	PROPN
ijpds-4459	307	2	nanotechnol	nanotechnol	NOUN
ijpds-4459	307	3	.	.	PUNCT
ijpds-4459	307	4	2017	2017	NUM
ijpds-4459	307	5	;	;	PUNCT
ijpds-4459	307	6	12(8):813	12(8):813	NUM
ijpds-4459	307	7	-	-	SYM
ijpds-4459	307	8	20	20	NUM
ijpds-4459	307	9	.	.	NOUN
ijpds-4459	307	10	19	19	NUM
ijpds-4459	307	11	.	.	PUNCT
ijpds-4459	308	1	dreaden	dreaden	PROPN
ijpds-4459	308	2	ec	ec	PROPN
ijpds-4459	308	3	,	,	PUNCT
ijpds-4459	308	4	alkilany	alkilany	NOUN
ijpds-4459	308	5	am	be	AUX
ijpds-4459	308	6	,	,	PUNCT
ijpds-4459	308	7	huang	huang	PROPN
ijpds-4459	308	8	x	x	PROPN
ijpds-4459	308	9	,	,	PUNCT
ijpds-4459	308	10	et	et	PROPN
ijpds-4459	308	11	al	al	PROPN
ijpds-4459	308	12	.	.	PUNCT
ijpds-4459	309	1	the	the	DET
ijpds-4459	309	2	golden	golden	ADJ
ijpds-4459	309	3	age	age	NOUN
ijpds-4459	309	4	:	:	PUNCT
ijpds-4459	309	5	gold	gold	NOUN
ijpds-4459	309	6	nanoparticles	nanoparticle	NOUN
ijpds-4459	309	7	for	for	ADP
ijpds-4459	309	8	biomedicine	biomedicine	NOUN
ijpds-4459	309	9	.	.	PUNCT
ijpds-4459	310	1	chem	chem	PROPN
ijpds-4459	310	2	soc	soc	PROPN
ijpds-4459	310	3	re	re	NOUN
ijpds-4459	310	4	.	.	PROPN
ijpds-4459	310	5	2012	2012	NUM
ijpds-4459	310	6	;	;	PUNCT
ijpds-4459	310	7	41(7):2740	41(7):2740	NOUN
ijpds-4459	310	8	-	-	SYM
ijpds-4459	310	9	79	79	NUM
ijpds-4459	310	10	.	.	PUNCT
ijpds-4459	310	11	20	20	NUM
ijpds-4459	310	12	.	.	PUNCT
ijpds-4459	311	1	annabi	annabi	PROPN
ijpds-4459	311	2	n	n	CCONJ
ijpds-4459	311	3	,	,	PUNCT
ijpds-4459	311	4	tamayol	tamayol	NOUN
ijpds-4459	311	5	a	a	PROPN
ijpds-4459	311	6	,	,	PUNCT
ijpds-4459	311	7	uquillas	uquillas	PROPN
ijpds-4459	311	8	ja	ja	PROPN
ijpds-4459	311	9	,	,	PUNCT
ijpds-4459	311	10	et	et	PROPN
ijpds-4459	311	11	al	al	PROPN
ijpds-4459	311	12	.	.	PUNCT
ijpds-4459	311	13	25th	25th	ADJ
ijpds-4459	311	14	anniversary	anniversary	NOUN
ijpds-4459	311	15	article	article	NOUN
ijpds-4459	311	16	:	:	PUNCT
ijpds-4459	311	17	rational	rational	ADJ
ijpds-4459	311	18	design	design	NOUN
ijpds-4459	311	19	and	and	CCONJ
ijpds-4459	311	20	applications	application	NOUN
ijpds-4459	311	21	of	of	ADP
ijpds-4459	311	22	hydrogels	hydrogel	NOUN
ijpds-4459	311	23	in	in	ADP
ijpds-4459	311	24	regenerative	regenerative	ADJ
ijpds-4459	311	25	medicine	medicine	NOUN
ijpds-4459	311	26	.	.	PUNCT
ijpds-4459	312	1	adv	adv	PROPN
ijpds-4459	312	2	mater	mater	PROPN
ijpds-4459	312	3	.	.	PUNCT
ijpds-4459	313	1	2014	2014	NUM
ijpds-4459	313	2	;	;	PUNCT
ijpds-4459	314	1	26(1):85	26(1):85	PROPN
ijpds-4459	314	2	-	-	SYM
ijpds-4459	314	3	123	123	NUM
ijpds-4459	314	4	.	.	PUNCT
ijpds-4459	315	1	21	21	NUM
ijpds-4459	315	2	.	.	PUNCT
ijpds-4459	316	1	wang	wang	PROPN
ijpds-4459	316	2	h	h	PROPN
ijpds-4459	316	3	,	,	PUNCT
ijpds-4459	316	4	la	la	PROPN
ijpds-4459	316	5	russa	russa	PROPN
ijpds-4459	316	6	m	m	PROPN
ijpds-4459	316	7	,	,	PUNCT
ijpds-4459	316	8	qi	qi	PROPN
ijpds-4459	316	9	ls	ls	PROPN
ijpds-4459	316	10	.	.	PROPN
ijpds-4459	316	11	crispr	crispr	PROPN
ijpds-4459	316	12	/	/	SYM
ijpds-4459	316	13	cas9	cas9	NOUN
ijpds-4459	316	14	in	in	ADP
ijpds-4459	316	15	genome	genome	NOUN
ijpds-4459	316	16	editing	editing	NOUN
ijpds-4459	316	17	and	and	CCONJ
ijpds-4459	316	18	beyond	beyond	ADP
ijpds-4459	316	19	.	.	PUNCT
ijpds-4459	317	1	annu	annu	PROPN
ijpds-4459	317	2	rev	rev	VERB
ijpds-4459	317	3	biochem	biochem	PROPN
ijpds-4459	317	4	.	.	PUNCT
ijpds-4459	318	1	2016	2016	NUM
ijpds-4459	318	2	;	;	PUNCT
ijpds-4459	318	3	85:227	85:227	NUM
ijpds-4459	318	4	-	-	SYM
ijpds-4459	318	5	64	64	NUM
ijpds-4459	318	6	.	.	PUNCT
ijpds-4459	319	1	bhat	bhat	PROPN
ijpds-4459	319	2	&	&	CCONJ
ijpds-4459	319	3	shanbhag	shanbhag	NOUN
ijpds-4459	319	4	biomaterials	biomaterial	NOUN
ijpds-4459	319	5	:	:	PUNCT
ijpds-4459	319	6	revolutionizing	revolutionize	VERB
ijpds-4459	319	7	cancer	cancer	NOUN
ijpds-4459	319	8	immunotherapy	immunotherapy	NOUN
ijpds-4459	319	9	and	and	CCONJ
ijpds-4459	319	10	genomics	genomics	NOUN
ijpds-4459	319	11	vol	vol	NOUN
ijpds-4459	319	12	3	3	NUM
ijpds-4459	319	13	|	|	NOUN
ijpds-4459	319	14	issue	issue	NOUN
ijpds-4459	319	15	2	2	NUM
ijpds-4459	319	16	|	|	ADV
ijpds-4459	319	17	apr	apr	NOUN
ijpds-4459	319	18	–	–	PUNCT
ijpds-4459	319	19	jun	jun	PROPN
ijpds-4459	319	20	2024	2024	NUM
ijpds-4459	319	21	indian	indian	PROPN
ijpds-4459	319	22	j	j	PROPN
ijpds-4459	319	23	pharm	pharm	PROPN
ijpds-4459	319	24	drug	drug	PROPN
ijpds-4459	319	25	studies	study	NOUN
ijpds-4459	319	26	|	|	ADV
ijpds-4459	319	27	44	44	NUM
ijpds-4459	319	28	22	22	NUM
ijpds-4459	319	29	.	.	PUNCT
ijpds-4459	320	1	cunningham	cunningham	PROPN
ijpds-4459	320	2	n	n	CCONJ
ijpds-4459	320	3	,	,	PUNCT
ijpds-4459	320	4	lapointe	lapointe	PROPN
ijpds-4459	320	5	r	r	PROPN
ijpds-4459	320	6	,	,	PUNCT
ijpds-4459	320	7	lerouge	lerouge	PROPN
ijpds-4459	320	8	s.	s.	PROPN
ijpds-4459	320	9	biomaterials	biomaterial	NOUN
ijpds-4459	320	10	for	for	ADP
ijpds-4459	320	11	enhanced	enhanced	ADJ
ijpds-4459	320	12	immunotherapy	immunotherapy	NOUN
ijpds-4459	320	13	.	.	PUNCT
ijpds-4459	321	1	apl	apl	PROPN
ijpds-4459	321	2	bioeng	bioeng	PROPN
ijpds-4459	321	3	.	.	PROPN
ijpds-4459	321	4	2022	2022	NUM
ijpds-4459	321	5	;	;	PUNCT
ijpds-4459	321	6	6(4).121548	6(4).121548	NUM
ijpds-4459	321	7	.	.	PUNCT
ijpds-4459	322	1	23	23	NUM
ijpds-4459	322	2	.	.	PUNCT
ijpds-4459	323	1	kamaly	kamaly	PROPN
ijpds-4459	323	2	n	n	PROPN
ijpds-4459	323	3	,	,	PUNCT
ijpds-4459	323	4	xiao	xiao	PROPN
ijpds-4459	323	5	z	z	PROPN
ijpds-4459	323	6	,	,	PUNCT
ijpds-4459	323	7	valencia	valencia	PROPN
ijpds-4459	323	8	pm	pm	NOUN
ijpds-4459	323	9	,	,	PUNCT
ijpds-4459	323	10	et	et	PROPN
ijpds-4459	323	11	al	al	PROPN
ijpds-4459	323	12	.	.	PROPN
ijpds-4459	323	13	targeted	target	VERB
ijpds-4459	323	14	polymeric	polymeric	ADJ
ijpds-4459	323	15	therapeutic	therapeutic	ADJ
ijpds-4459	323	16	nanoparticles	nanoparticle	NOUN
ijpds-4459	323	17	:	:	PUNCT
ijpds-4459	323	18	design	design	NOUN
ijpds-4459	323	19	,	,	PUNCT
ijpds-4459	323	20	development	development	NOUN
ijpds-4459	323	21	and	and	CCONJ
ijpds-4459	323	22	clinical	clinical	ADJ
ijpds-4459	323	23	translation	translation	NOUN
ijpds-4459	323	24	.	.	PUNCT
ijpds-4459	324	1	chem	chem	PROPN
ijpds-4459	324	2	soc	soc	PROPN
ijpds-4459	324	3	rev	rev	VERB
ijpds-4459	324	4	.	.	PROPN
ijpds-4459	324	5	2012	2012	NUM
ijpds-4459	324	6	;	;	PUNCT
ijpds-4459	324	7	41(7):2971	41(7):2971	NUM
ijpds-4459	324	8	-	-	SYM
ijpds-4459	324	9	3010	3010	NUM
ijpds-4459	324	10	.	.	PUNCT
ijpds-4459	325	1	24	24	NUM
ijpds-4459	325	2	.	.	PUNCT
ijpds-4459	326	1	shi	shi	PROPN
ijpds-4459	326	2	j	j	PROPN
ijpds-4459	326	3	,	,	PUNCT
ijpds-4459	326	4	wang	wang	PROPN
ijpds-4459	326	5	l	l	PROPN
ijpds-4459	326	6	,	,	PUNCT
ijpds-4459	326	7	zhang	zhang	PROPN
ijpds-4459	326	8	s	s	PROPN
ijpds-4459	326	9	,	,	PUNCT
ijpds-4459	326	10	et	et	PROPN
ijpds-4459	326	11	al	al	PROPN
ijpds-4459	326	12	.	.	PROPN
ijpds-4459	326	13	biomaterial	biomaterial	NOUN
ijpds-4459	326	14	-	-	PUNCT
ijpds-4459	326	15	based	base	VERB
ijpds-4459	326	16	delivery	delivery	NOUN
ijpds-4459	326	17	of	of	ADP
ijpds-4459	326	18	crispr	crispr	ADJ
ijpds-4459	326	19	-	-	PUNCT
ijpds-4459	326	20	cas9	cas9	NOUN
ijpds-4459	326	21	system	system	NOUN
ijpds-4459	326	22	for	for	ADP
ijpds-4459	326	23	cancer	cancer	NOUN
ijpds-4459	326	24	therapy	therapy	NOUN
ijpds-4459	326	25	.	.	PUNCT
ijpds-4459	327	1	bioact	bioact	ADJ
ijpds-4459	327	2	mater	mater	NOUN
ijpds-4459	327	3	.	.	PUNCT
ijpds-4459	328	1	2020	2020	NUM
ijpds-4459	328	2	;	;	PUNCT
ijpds-4459	329	1	5(4):38	5(4):38	NUM
ijpds-4459	329	2	.	.	PUNCT
ijpds-4459	330	1	25	25	NUM
ijpds-4459	330	2	.	.	PUNCT
ijpds-4459	330	3	topalian	topalian	PROPN
ijpds-4459	330	4	sl	sl	PROPN
ijpds-4459	330	5	,	,	PUNCT
ijpds-4459	330	6	hodi	hodi	PROPN
ijpds-4459	330	7	fs	fs	PROPN
ijpds-4459	330	8	,	,	PUNCT
ijpds-4459	330	9	brahmer	brahmer	PROPN
ijpds-4459	330	10	jr	jr	PROPN
ijpds-4459	330	11	,	,	PUNCT
ijpds-4459	330	12	et	et	PROPN
ijpds-4459	330	13	al	al	PROPN
ijpds-4459	330	14	.	.	PROPN
ijpds-4459	330	15	safety	safety	NOUN
ijpds-4459	330	16	and	and	CCONJ
ijpds-4459	330	17	activity	activity	NOUN
ijpds-4459	330	18	of	of	ADP
ijpds-4459	330	19	anti	anti	ADJ
ijpds-4459	330	20	-	-	ADJ
ijpds-4459	330	21	pd-1	pd-1	ADJ
ijpds-4459	330	22	antibody	antibody	NOUN
ijpds-4459	330	23	(	(	PUNCT
ijpds-4459	330	24	nivolumab	nivolumab	NOUN
ijpds-4459	330	25	)	)	PUNCT
ijpds-4459	330	26	in	in	ADP
ijpds-4459	330	27	patients	patient	NOUN
ijpds-4459	330	28	with	with	ADP
ijpds-4459	330	29	recurrent	recurrent	ADJ
ijpds-4459	330	30	or	or	CCONJ
ijpds-4459	330	31	metastatic	metastatic	ADJ
ijpds-4459	330	32	non	non	ADJ
ijpds-4459	330	33	-	-	ADJ
ijpds-4459	330	34	small	small	ADJ
ijpds-4459	330	35	-	-	PUNCT
ijpds-4459	330	36	cell	cell	NOUN
ijpds-4459	330	37	lung	lung	NOUN
ijpds-4459	330	38	cancer	cancer	NOUN
ijpds-4459	330	39	.	.	PUNCT
ijpds-4459	331	1	j	j	PROPN
ijpds-4459	331	2	clin	clin	PROPN
ijpds-4459	331	3	oncol	oncol	PROPN
ijpds-4459	331	4	.	.	PUNCT
ijpds-4459	332	1	2012	2012	NUM
ijpds-4459	332	2	;	;	PUNCT
ijpds-4459	333	1	30(17):2112	30(17):2112	NUM
ijpds-4459	333	2	-	-	SYM
ijpds-4459	333	3	20	20	NUM
ijpds-4459	333	4	.	.	PUNCT
ijpds-4459	333	5	26	26	NUM
ijpds-4459	333	6	.	.	PUNCT
ijpds-4459	334	1	palucka	palucka	PROPN
ijpds-4459	334	2	k	k	PROPN
ijpds-4459	334	3	,	,	PUNCT
ijpds-4459	334	4	ueno	ueno	PROPN
ijpds-4459	334	5	h	h	PROPN
ijpds-4459	334	6	,	,	PUNCT
ijpds-4459	334	7	fay	fay	PROPN
ijpds-4459	334	8	j	j	PROPN
ijpds-4459	334	9	,	,	PUNCT
ijpds-4459	334	10	et	et	PROPN
ijpds-4459	334	11	al	al	PROPN
ijpds-4459	334	12	.	.	PUNCT
ijpds-4459	335	1	dendritic	dendritic	ADJ
ijpds-4459	335	2	cell	cell	NOUN
ijpds-4459	335	3	-	-	PUNCT
ijpds-4459	335	4	based	base	VERB
ijpds-4459	335	5	therapeutic	therapeutic	ADJ
ijpds-4459	335	6	vaccines	vaccine	NOUN
ijpds-4459	335	7	.	.	PUNCT
ijpds-4459	336	1	annu	annu	PROPN
ijpds-4459	336	2	rev	rev	VERB
ijpds-4459	336	3	immunol	immunol	NOUN
ijpds-4459	336	4	.	.	PUNCT
ijpds-4459	337	1	2010	2010	NUM
ijpds-4459	337	2	;	;	PUNCT
ijpds-4459	337	3	28:237	28:237	NUM
ijpds-4459	337	4	-	-	SYM
ijpds-4459	337	5	69	69	NUM
ijpds-4459	337	6	.	.	PUNCT
ijpds-4459	338	1	27	27	NUM
ijpds-4459	338	2	.	.	PUNCT
ijpds-4459	339	1	kim	kim	PROPN
ijpds-4459	339	2	j	j	PROPN
ijpds-4459	339	3	,	,	PUNCT
ijpds-4459	339	4	choi	choi	PROPN
ijpds-4459	339	5	y	y	PROPN
ijpds-4459	339	6	,	,	PUNCT
ijpds-4459	339	7	kim	kim	PROPN
ijpds-4459	339	8	dh	dh	PROPN
ijpds-4459	339	9	,	,	PUNCT
ijpds-4459	339	10	et	et	PROPN
ijpds-4459	339	11	al	al	PROPN
ijpds-4459	339	12	.	.	PUNCT
ijpds-4459	340	1	injectable	injectable	ADJ
ijpds-4459	340	2	hydrogel	hydrogel	NOUN
ijpds-4459	340	3	-	-	PUNCT
ijpds-4459	340	4	based	base	VERB
ijpds-4459	340	5	combination	combination	NOUN
ijpds-4459	340	6	cancer	cancer	NOUN
ijpds-4459	340	7	immunotherapy	immunotherapy	NOUN
ijpds-4459	340	8	for	for	ADP
ijpds-4459	340	9	overcoming	overcome	VERB
ijpds-4459	340	10	localized	localize	VERB
ijpds-4459	340	11	therapeutic	therapeutic	ADJ
ijpds-4459	340	12	efficacy	efficacy	NOUN
ijpds-4459	340	13	.	.	PUNCT
ijpds-4459	341	1	pharmaceutics	pharmaceutic	NOUN
ijpds-4459	341	2	.	.	PUNCT
ijpds-4459	341	3	2022	2022	NUM
ijpds-4459	341	4	;	;	PUNCT
ijpds-4459	341	5	14(9):1908	14(9):1908	NUM
ijpds-4459	341	6	.	.	PUNCT
ijpds-4459	342	1	28	28	NUM
ijpds-4459	342	2	.	.	PUNCT
ijpds-4459	343	1	chen	chen	PROPN
ijpds-4459	343	2	z	z	PROPN
ijpds-4459	343	3	,	,	PUNCT
ijpds-4459	343	4	yue	yue	PROPN
ijpds-4459	343	5	z	z	PROPN
ijpds-4459	343	6	,	,	PUNCT
ijpds-4459	343	7	wang	wang	PROPN
ijpds-4459	343	8	r	r	PROPN
ijpds-4459	343	9	,	,	PUNCT
ijpds-4459	343	10	et	et	PROPN
ijpds-4459	343	11	al	al	PROPN
ijpds-4459	343	12	.	.	PROPN
ijpds-4459	343	13	nanomaterials	nanomaterial	NOUN
ijpds-4459	343	14	:	:	PUNCT
ijpds-4459	343	15	a	a	DET
ijpds-4459	343	16	powerful	powerful	ADJ
ijpds-4459	343	17	tool	tool	NOUN
ijpds-4459	343	18	for	for	ADP
ijpds-4459	343	19	tumour	tumour	NOUN
ijpds-4459	343	20	immunotherapy	immunotherapy	NOUN
ijpds-4459	343	21	.	.	PUNCT
ijpds-4459	344	1	front	front	ADJ
ijpds-4459	344	2	immunol	immunol	NOUN
ijpds-4459	344	3	.	.	PUNCT
ijpds-4459	345	1	2022	2022	NUM
ijpds-4459	345	2	;	;	PUNCT
ijpds-4459	345	3	13:979469	13:979469	NUM
ijpds-4459	345	4	.	.	NOUN
ijpds-4459	345	5	29	29	NUM
ijpds-4459	345	6	.	.	PUNCT
ijpds-4459	346	1	li	li	PROPN
ijpds-4459	346	2	y	y	PROPN
ijpds-4459	346	3	,	,	PUNCT
ijpds-4459	346	4	li	li	PROPN
ijpds-4459	346	5	s	s	PROPN
ijpds-4459	346	6	,	,	PUNCT
ijpds-4459	346	7	jiang	jiang	PROPN
ijpds-4459	346	8	z	z	PROPN
ijpds-4459	346	9	,	,	PUNCT
ijpds-4459	346	10	et	et	PROPN
ijpds-4459	346	11	al	al	PROPN
ijpds-4459	346	12	.	.	PUNCT
ijpds-4459	346	13	targeting	target	VERB
ijpds-4459	346	14	lymph	lymph	NOUN
ijpds-4459	346	15	node	node	NOUN
ijpds-4459	346	16	delivery	delivery	NOUN
ijpds-4459	346	17	with	with	ADP
ijpds-4459	346	18	nanovaccines	nanovaccine	NOUN
ijpds-4459	346	19	for	for	ADP
ijpds-4459	346	20	cancer	cancer	NOUN
ijpds-4459	346	21	immunotherapy	immunotherapy	NOUN
ijpds-4459	346	22	:	:	PUNCT
ijpds-4459	346	23	recent	recent	ADJ
ijpds-4459	346	24	advances	advance	NOUN
ijpds-4459	346	25	and	and	CCONJ
ijpds-4459	346	26	future	future	ADJ
ijpds-4459	346	27	directions	direction	NOUN
ijpds-4459	346	28	.	.	PUNCT
ijpds-4459	347	1	j	j	PROPN
ijpds-4459	347	2	nanobiotechnol	nanobiotechnol	NOUN
ijpds-4459	347	3	.	.	PUNCT
ijpds-4459	348	1	2023	2023	NUM
ijpds-4459	348	2	;	;	PUNCT
ijpds-4459	348	3	21(1):212	21(1):212	NUM
ijpds-4459	348	4	.	.	PUNCT
ijpds-4459	349	1	30	30	NUM
ijpds-4459	349	2	.	.	PUNCT
ijpds-4459	350	1	bezbaruah	bezbaruah	NOUN
ijpds-4459	350	2	r	r	NOUN
ijpds-4459	350	3	,	,	PUNCT
ijpds-4459	350	4	chavda	chavda	PROPN
ijpds-4459	350	5	vp	vp	PROPN
ijpds-4459	350	6	,	,	PUNCT
ijpds-4459	350	7	nongrang	nongrang	PROPN
ijpds-4459	350	8	l	l	PROPN
ijpds-4459	350	9	,	,	PUNCT
ijpds-4459	350	10	et	et	PROPN
ijpds-4459	350	11	al	al	PROPN
ijpds-4459	350	12	.	.	PROPN
ijpds-4459	350	13	nanoparticle	nanoparticle	NOUN
ijpds-4459	350	14	-	-	PUNCT
ijpds-4459	350	15	based	base	VERB
ijpds-4459	350	16	delivery	delivery	NOUN
ijpds-4459	350	17	systems	system	NOUN
ijpds-4459	350	18	for	for	ADP
ijpds-4459	350	19	vaccines	vaccine	NOUN
ijpds-4459	350	20	.	.	PUNCT
ijpds-4459	351	1	vaccines	vaccine	NOUN
ijpds-4459	351	2	.	.	PUNCT
ijpds-4459	352	1	2022	2022	NUM
ijpds-4459	352	2	;	;	PUNCT
ijpds-4459	353	1	10(11):1946	10(11):1946	NUM
ijpds-4459	353	2	.	.	NOUN
ijpds-4459	353	3	31	31	NUM
ijpds-4459	353	4	.	.	PUNCT
ijpds-4459	354	1	vanneman	vanneman	PROPN
ijpds-4459	354	2	m	m	PROPN
ijpds-4459	354	3	,	,	PUNCT
ijpds-4459	354	4	dranoff	dranoff	PROPN
ijpds-4459	354	5	g.	g.	NOUN
ijpds-4459	354	6	combining	combine	VERB
ijpds-4459	354	7	immunotherapy	immunotherapy	NOUN
ijpds-4459	354	8	and	and	CCONJ
ijpds-4459	354	9	targeted	target	VERB
ijpds-4459	354	10	therapies	therapy	NOUN
ijpds-4459	354	11	in	in	ADP
ijpds-4459	354	12	cancer	cancer	NOUN
ijpds-4459	354	13	treatment	treatment	NOUN
ijpds-4459	354	14	.	.	PUNCT
ijpds-4459	355	1	nat	nat	PROPN
ijpds-4459	355	2	rev	rev	PROPN
ijpds-4459	355	3	cancer	cancer	NOUN
ijpds-4459	355	4	.	.	PUNCT
ijpds-4459	356	1	2012	2012	NUM
ijpds-4459	356	2	;	;	PUNCT
ijpds-4459	356	3	12(4):237	12(4):237	NUM
ijpds-4459	356	4	-	-	SYM
ijpds-4459	356	5	51	51	NUM
ijpds-4459	356	6	.	.	PUNCT
ijpds-4459	357	1	32	32	NUM
ijpds-4459	357	2	.	.	PUNCT
ijpds-4459	358	1	zhang	zhang	PROPN
ijpds-4459	358	2	r	r	PROPN
ijpds-4459	358	3	,	,	PUNCT
ijpds-4459	358	4	billingsley	billingsley	PROPN
ijpds-4459	358	5	mm	mm	PROPN
ijpds-4459	358	6	,	,	PUNCT
ijpds-4459	358	7	mitchell	mitchell	PROPN
ijpds-4459	358	8	mj	mj	PROPN
ijpds-4459	358	9	.	.	PROPN
ijpds-4459	358	10	biomaterials	biomaterial	NOUN
ijpds-4459	358	11	for	for	ADP
ijpds-4459	358	12	vaccine	vaccine	NOUN
ijpds-4459	358	13	-	-	PUNCT
ijpds-4459	358	14	based	base	VERB
ijpds-4459	358	15	cancer	cancer	NOUN
ijpds-4459	358	16	immunotherapy	immunotherapy	NOUN
ijpds-4459	358	17	.	.	PUNCT
ijpds-4459	359	1	j	j	PROPN
ijpds-4459	359	2	control	control	PROPN
ijpds-4459	359	3	release	release	PROPN
ijpds-4459	359	4	.	.	PUNCT
ijpds-4459	360	1	2018	2018	NUM
ijpds-4459	360	2	;	;	PUNCT
ijpds-4459	360	3	292:256	292:256	NUM
ijpds-4459	360	4	-	-	SYM
ijpds-4459	360	5	76	76	NUM
ijpds-4459	360	6	.	.	PUNCT
ijpds-4459	361	1	33	33	NUM
ijpds-4459	361	2	.	.	PUNCT
ijpds-4459	362	1	gonzalez	gonzalez	PROPN
ijpds-4459	362	2	h	h	PROPN
ijpds-4459	362	3	,	,	PUNCT
ijpds-4459	362	4	hagerling	hagerle	VERB
ijpds-4459	362	5	c	c	NOUN
ijpds-4459	362	6	,	,	PUNCT
ijpds-4459	362	7	werb	werb	ADJ
ijpds-4459	362	8	z.	z.	PROPN
ijpds-4459	362	9	roles	role	NOUN
ijpds-4459	362	10	of	of	ADP
ijpds-4459	362	11	the	the	DET
ijpds-4459	362	12	immune	immune	ADJ
ijpds-4459	362	13	system	system	NOUN
ijpds-4459	362	14	in	in	ADP
ijpds-4459	362	15	cancer	cancer	NOUN
ijpds-4459	362	16	:	:	PUNCT
ijpds-4459	362	17	from	from	ADP
ijpds-4459	362	18	tumour	tumour	PRON
ijpds-4459	362	19	initiation	initiation	NOUN
ijpds-4459	362	20	to	to	ADP
ijpds-4459	362	21	metastatic	metastatic	ADJ
ijpds-4459	362	22	progression	progression	NOUN
ijpds-4459	362	23	.	.	PUNCT
ijpds-4459	363	1	genes	gene	NOUN
ijpds-4459	363	2	dev	dev	PROPN
ijpds-4459	363	3	.	.	PROPN
ijpds-4459	363	4	2018	2018	NUM
ijpds-4459	363	5	;	;	PUNCT
ijpds-4459	363	6	32(19–20):1267	32(19–20):1267	NUM
ijpds-4459	363	7	-	-	SYM
ijpds-4459	363	8	84	84	NUM
ijpds-4459	363	9	.	.	PUNCT
ijpds-4459	364	1	34	34	NUM
ijpds-4459	364	2	.	.	PUNCT
ijpds-4459	364	3	olson	olson	PROPN
ijpds-4459	364	4	dj	dj	PROPN
ijpds-4459	364	5	,	,	PUNCT
ijpds-4459	364	6	odunsi	odunsi	PROPN
ijpds-4459	364	7	k.	k.	PROPN
ijpds-4459	364	8	adoptive	adoptive	PROPN
ijpds-4459	364	9	cell	cell	NOUN
ijpds-4459	364	10	therapy	therapy	NOUN
ijpds-4459	364	11	for	for	ADP
ijpds-4459	364	12	nonhematologic	nonhematologic	ADJ
ijpds-4459	364	13	solid	solid	ADJ
ijpds-4459	364	14	tumours	tumour	NOUN
ijpds-4459	364	15	.	.	PUNCT
ijpds-4459	365	1	j	j	PROPN
ijpds-4459	365	2	clin	clin	PROPN
ijpds-4459	365	3	oncol	oncol	PROPN
ijpds-4459	365	4	.	.	PUNCT
ijpds-4459	366	1	2023	2023	NUM
ijpds-4459	366	2	;	;	PUNCT
ijpds-4459	366	3	41(18):3397	41(18):3397	X
ijpds-4459	366	4	-	-	SYM
ijpds-4459	366	5	407	407	NUM
ijpds-4459	366	6	.	.	PUNCT
ijpds-4459	367	1	35	35	NUM
ijpds-4459	367	2	.	.	PUNCT
ijpds-4459	368	1	rosenberg	rosenberg	PROPN
ijpds-4459	368	2	sa	sa	PROPN
ijpds-4459	368	3	,	,	PUNCT
ijpds-4459	368	4	restifo	restifo	ADJ
ijpds-4459	368	5	np	np	ADP
ijpds-4459	368	6	,	,	PUNCT
ijpds-4459	368	7	yang	yang	PROPN
ijpds-4459	368	8	jc	jc	PROPN
ijpds-4459	368	9	,	,	PUNCT
ijpds-4459	368	10	et	et	PROPN
ijpds-4459	368	11	al	al	PROPN
ijpds-4459	368	12	.	.	PROPN
ijpds-4459	368	13	adoptive	adoptive	ADJ
ijpds-4459	368	14	cell	cell	NOUN
ijpds-4459	368	15	transfer	transfer	NOUN
ijpds-4459	368	16	:	:	PUNCT
ijpds-4459	368	17	a	a	DET
ijpds-4459	368	18	clinical	clinical	ADJ
ijpds-4459	368	19	path	path	NOUN
ijpds-4459	368	20	to	to	ADP
ijpds-4459	368	21	effective	effective	ADJ
ijpds-4459	368	22	cancer	cancer	NOUN
ijpds-4459	368	23	immunotherapy	immunotherapy	NOUN
ijpds-4459	368	24	.	.	PUNCT
ijpds-4459	369	1	nat	nat	PROPN
ijpds-4459	369	2	rev	rev	PROPN
ijpds-4459	369	3	cancer	cancer	NOUN
ijpds-4459	369	4	.	.	PUNCT
ijpds-4459	369	5	2008	2008	NUM
ijpds-4459	369	6	;	;	PUNCT
ijpds-4459	369	7	8(4):299	8(4):299	NUM
ijpds-4459	369	8	-	-	SYM
ijpds-4459	369	9	308	308	NUM
ijpds-4459	369	10	.	.	PUNCT
ijpds-4459	370	1	36	36	NUM
ijpds-4459	370	2	.	.	PUNCT
ijpds-4459	371	1	kirtane	kirtane	PROPN
ijpds-4459	371	2	k	k	PROPN
ijpds-4459	371	3	,	,	PUNCT
ijpds-4459	371	4	elmariah	elmariah	PROPN
ijpds-4459	371	5	h	h	NOUN
ijpds-4459	371	6	,	,	PUNCT
ijpds-4459	371	7	chung	chung	PROPN
ijpds-4459	371	8	ch	ch	PROPN
ijpds-4459	371	9	,	,	PUNCT
ijpds-4459	371	10	et	et	PROPN
ijpds-4459	371	11	al	al	PROPN
ijpds-4459	371	12	.	.	PROPN
ijpds-4459	371	13	adoptive	adoptive	ADJ
ijpds-4459	371	14	cellular	cellular	ADJ
ijpds-4459	371	15	therapy	therapy	NOUN
ijpds-4459	371	16	in	in	ADP
ijpds-4459	371	17	solid	solid	ADJ
ijpds-4459	371	18	tumour	tumour	ADJ
ijpds-4459	371	19	malignancies	malignancy	NOUN
ijpds-4459	371	20	:	:	PUNCT
ijpds-4459	371	21	review	review	NOUN
ijpds-4459	371	22	of	of	ADP
ijpds-4459	371	23	the	the	DET
ijpds-4459	371	24	literature	literature	NOUN
ijpds-4459	371	25	and	and	CCONJ
ijpds-4459	371	26	challenges	challenge	NOUN
ijpds-4459	371	27	ahead	ahead	ADV
ijpds-4459	371	28	.	.	PUNCT
ijpds-4459	372	1	j	j	PROPN
ijpds-4459	372	2	immunother	immunother	ADJ
ijpds-4459	372	3	cancer	cancer	NOUN
ijpds-4459	372	4	.	.	PUNCT
ijpds-4459	373	1	2021;9(7):e002723	2021;9(7):e002723	X
ijpds-4459	373	2	.	.	PUNCT
ijpds-4459	374	1	37	37	NUM
ijpds-4459	374	2	.	.	PUNCT
ijpds-4459	375	1	juat	juat	PROPN
ijpds-4459	375	2	dj	dj	PROPN
ijpds-4459	375	3	,	,	PUNCT
ijpds-4459	375	4	hachey	hachey	PROPN
ijpds-4459	375	5	sj	sj	PROPN
ijpds-4459	375	6	,	,	PUNCT
ijpds-4459	375	7	billimek	billimek	PROPN
ijpds-4459	375	8	j	j	PROPN
ijpds-4459	375	9	,	,	PUNCT
ijpds-4459	375	10	et	et	PROPN
ijpds-4459	375	11	al	al	PROPN
ijpds-4459	375	12	.	.	PROPN
ijpds-4459	375	13	adoptive	adoptive	PROPN
ijpds-4459	375	14	t	t	PROPN
ijpds-4459	375	15	-	-	PUNCT
ijpds-4459	375	16	cell	cell	NOUN
ijpds-4459	375	17	therapy	therapy	NOUN
ijpds-4459	375	18	in	in	ADP
ijpds-4459	375	19	advanced	advanced	ADJ
ijpds-4459	375	20	colorectal	colorectal	ADJ
ijpds-4459	375	21	cancer	cancer	NOUN
ijpds-4459	375	22	:	:	PUNCT
ijpds-4459	375	23	a	a	DET
ijpds-4459	375	24	systematic	systematic	ADJ
ijpds-4459	375	25	review	review	NOUN
ijpds-4459	375	26	.	.	PUNCT
ijpds-4459	376	1	oncologist	oncologist	NOUN
ijpds-4459	376	2	.	.	PUNCT
ijpds-4459	377	1	2022	2022	NUM
ijpds-4459	377	2	;	;	PUNCT
ijpds-4459	377	3	27(3):210	27(3):210	NOUN
ijpds-4459	377	4	-	-	SYM
ijpds-4459	377	5	9	9	NUM
ijpds-4459	377	6	.	.	NOUN
ijpds-4459	377	7	38	38	NUM
ijpds-4459	377	8	.	.	PUNCT
ijpds-4459	378	1	doudna	doudna	PROPN
ijpds-4459	378	2	ja	ja	PROPN
ijpds-4459	378	3	,	,	PUNCT
ijpds-4459	378	4	charpentier	charpentier	PROPN
ijpds-4459	378	5	e.	e.	PROPN
ijpds-4459	378	6	the	the	DET
ijpds-4459	378	7	new	new	ADJ
ijpds-4459	378	8	frontier	frontier	NOUN
ijpds-4459	378	9	of	of	ADP
ijpds-4459	378	10	genome	genome	NOUN
ijpds-4459	378	11	engineering	engineering	NOUN
ijpds-4459	378	12	with	with	ADP
ijpds-4459	378	13	crispr	crispr	NOUN
ijpds-4459	378	14	-	-	PUNCT
ijpds-4459	378	15	cas9	cas9	NOUN
ijpds-4459	378	16	.	.	PUNCT
ijpds-4459	379	1	science	science	NOUN
ijpds-4459	379	2	.	.	PUNCT
ijpds-4459	380	1	2014	2014	NUM
ijpds-4459	380	2	;	;	PUNCT
ijpds-4459	380	3	346(6213	346(6213	NUM
ijpds-4459	380	4	)	)	PUNCT
ijpds-4459	380	5	.	.	PUNCT
ijpds-4459	381	1	39	39	NUM
ijpds-4459	381	2	.	.	PUNCT
ijpds-4459	382	1	wang	wang	PROPN
ijpds-4459	382	2	m	m	PROPN
ijpds-4459	382	3	,	,	PUNCT
ijpds-4459	382	4	zuris	zuris	PROPN
ijpds-4459	382	5	ja	ja	PROPN
ijpds-4459	382	6	,	,	PUNCT
ijpds-4459	382	7	meng	meng	PROPN
ijpds-4459	382	8	f	f	PROPN
ijpds-4459	382	9	,	,	PUNCT
ijpds-4459	382	10	et	et	PROPN
ijpds-4459	382	11	al	al	PROPN
ijpds-4459	382	12	.	.	PROPN
ijpds-4459	382	13	efficient	efficient	ADJ
ijpds-4459	382	14	delivery	delivery	NOUN
ijpds-4459	382	15	of	of	ADP
ijpds-4459	382	16	genomeediting	genomeediting	NOUN
ijpds-4459	382	17	proteins	protein	NOUN
ijpds-4459	382	18	using	use	VERB
ijpds-4459	382	19	bioreducible	bioreducible	ADJ
ijpds-4459	382	20	lipid	lipid	NOUN
ijpds-4459	382	21	nanoparticles	nanoparticle	NOUN
ijpds-4459	382	22	.	.	PUNCT
ijpds-4459	383	1	proc	proc	PROPN
ijpds-4459	383	2	natl	natl	PROPN
ijpds-4459	383	3	acad	acad	PROPN
ijpds-4459	383	4	sci	sci	PROPN
ijpds-4459	383	5	usa	usa	PROPN
ijpds-4459	383	6	.	.	PROPN
ijpds-4459	383	7	2016	2016	NUM
ijpds-4459	383	8	;	;	PUNCT
ijpds-4459	383	9	113(11):2868–73	113(11):2868–73	NUM
ijpds-4459	383	10	.	.	NOUN
ijpds-4459	383	11	40	40	NUM
ijpds-4459	383	12	.	.	PUNCT
ijpds-4459	384	1	pan	pan	PROPN
ijpds-4459	384	2	x	x	PROPN
ijpds-4459	384	3	,	,	PUNCT
ijpds-4459	384	4	veroniaina	veroniaina	PROPN
ijpds-4459	384	5	h	h	PROPN
ijpds-4459	384	6	,	,	PUNCT
ijpds-4459	384	7	su	su	PROPN
ijpds-4459	384	8	n	n	PROPN
ijpds-4459	384	9	,	,	PUNCT
ijpds-4459	384	10	et	et	PROPN
ijpds-4459	384	11	al	al	PROPN
ijpds-4459	384	12	.	.	PROPN
ijpds-4459	384	13	applications	application	NOUN
ijpds-4459	384	14	and	and	CCONJ
ijpds-4459	384	15	developments	development	NOUN
ijpds-4459	384	16	of	of	ADP
ijpds-4459	384	17	gene	gene	NOUN
ijpds-4459	384	18	therapy	therapy	NOUN
ijpds-4459	384	19	drug	drug	NOUN
ijpds-4459	384	20	delivery	delivery	NOUN
ijpds-4459	384	21	systems	system	NOUN
ijpds-4459	384	22	for	for	ADP
ijpds-4459	384	23	genetic	genetic	ADJ
ijpds-4459	384	24	diseases	disease	NOUN
ijpds-4459	384	25	.	.	PUNCT
ijpds-4459	385	1	asian	asian	PROPN
ijpds-4459	385	2	j	j	PROPN
ijpds-4459	385	3	pharm	pharm	PROPN
ijpds-4459	385	4	sci	sci	PROPN
ijpds-4459	385	5	.	.	PROPN
ijpds-4459	385	6	2021	2021	NUM
ijpds-4459	385	7	;	;	PUNCT
ijpds-4459	385	8	16(6):687–703	16(6):687–703	NUM
ijpds-4459	385	9	.	.	NOUN
ijpds-4459	385	10	41	41	NUM
ijpds-4459	385	11	.	.	PUNCT
ijpds-4459	386	1	chen	chen	PROPN
ijpds-4459	386	2	g	g	PROPN
ijpds-4459	386	3	,	,	PUNCT
ijpds-4459	386	4	abdeen	abdeen	NOUN
ijpds-4459	386	5	aa	aa	NOUN
ijpds-4459	386	6	,	,	PUNCT
ijpds-4459	386	7	wang	wang	PROPN
ijpds-4459	386	8	y	y	PROPN
ijpds-4459	386	9	,	,	PUNCT
ijpds-4459	386	10	et	et	PROPN
ijpds-4459	386	11	al	al	PROPN
ijpds-4459	386	12	.	.	PUNCT
ijpds-4459	387	1	a	a	DET
ijpds-4459	387	2	biodegradable	biodegradable	ADJ
ijpds-4459	387	3	nanocapsule	nanocapsule	NOUN
ijpds-4459	387	4	delivers	deliver	VERB
ijpds-4459	387	5	a	a	DET
ijpds-4459	387	6	cas9	cas9	NOUN
ijpds-4459	387	7	ribonucleoprotein	ribonucleoprotein	NOUN
ijpds-4459	387	8	complex	complex	NOUN
ijpds-4459	387	9	for	for	ADP
ijpds-4459	387	10	in	in	ADP
ijpds-4459	387	11	vivo	vivo	ADJ
ijpds-4459	387	12	genome	genome	NOUN
ijpds-4459	387	13	editing	editing	NOUN
ijpds-4459	387	14	.	.	PUNCT
ijpds-4459	388	1	nat	nat	PROPN
ijpds-4459	388	2	nanotechnol	nanotechnol	NOUN
ijpds-4459	388	3	.	.	PUNCT
ijpds-4459	388	4	2019	2019	NUM
ijpds-4459	388	5	;	;	PUNCT
ijpds-4459	388	6	14(10):974–80	14(10):974–80	PROPN
ijpds-4459	388	7	.	.	PROPN
ijpds-4459	388	8	42	42	NUM
ijpds-4459	388	9	.	.	PUNCT
ijpds-4459	389	1	sahel	sahel	PROPN
ijpds-4459	389	2	dk	dk	PROPN
ijpds-4459	389	3	,	,	PUNCT
ijpds-4459	389	4	vora	vora	PROPN
ijpds-4459	389	5	lk	lk	PROPN
ijpds-4459	389	6	,	,	PUNCT
ijpds-4459	389	7	saraswat	saraswat	VERB
ijpds-4459	389	8	a	a	PRON
ijpds-4459	389	9	,	,	PUNCT
ijpds-4459	389	10	et	et	PROPN
ijpds-4459	389	11	al	al	PROPN
ijpds-4459	389	12	.	.	PROPN
ijpds-4459	389	13	crispr	crispr	PROPN
ijpds-4459	389	14	/	/	SYM
ijpds-4459	389	15	cas9	cas9	NOUN
ijpds-4459	389	16	genome	genome	NOUN
ijpds-4459	389	17	editing	editing	NOUN
ijpds-4459	389	18	for	for	ADP
ijpds-4459	389	19	tissue‐specific	tissue‐specific	PROPN
ijpds-4459	389	20	in	in	ADP
ijpds-4459	389	21	vivo	vivo	ADJ
ijpds-4459	389	22	targeting	targeting	NOUN
ijpds-4459	389	23	:	:	PUNCT
ijpds-4459	389	24	nanomaterials	nanomaterial	NOUN
ijpds-4459	389	25	and	and	CCONJ
ijpds-4459	389	26	translational	translational	ADJ
ijpds-4459	389	27	perspective	perspective	NOUN
ijpds-4459	389	28	.	.	PUNCT
ijpds-4459	390	1	adv	adv	PROPN
ijpds-4459	390	2	sci	sci	PROPN
ijpds-4459	390	3	.	.	PROPN
ijpds-4459	391	1	2023;10(19	2023;10(19	NUM
ijpds-4459	391	2	)	)	PUNCT
ijpds-4459	391	3	.	.	PUNCT
ijpds-4459	392	1	available	available	ADJ
ijpds-4459	392	2	from	from	ADP
ijpds-4459	392	3	:	:	PUNCT
ijpds-4459	392	4	https://doi.org/10.1002/advs.202207512	https://doi.org/10.1002/advs.202207512	NOUN
ijpds-4459	392	5	.	.	PUNCT
ijpds-4459	393	1	43	43	NUM
ijpds-4459	393	2	.	.	PUNCT
ijpds-4459	394	1	liang	liang	PROPN
ijpds-4459	394	2	c	c	PROPN
ijpds-4459	394	3	,	,	PUNCT
ijpds-4459	394	4	li	li	PROPN
ijpds-4459	394	5	f	f	PROPN
ijpds-4459	394	6	,	,	PUNCT
ijpds-4459	394	7	wang	wang	PROPN
ijpds-4459	394	8	l	l	PROPN
ijpds-4459	394	9	,	,	PUNCT
ijpds-4459	394	10	et	et	PROPN
ijpds-4459	394	11	al	al	PROPN
ijpds-4459	394	12	.	.	PUNCT
ijpds-4459	395	1	tumour	tumour	PRON
ijpds-4459	395	2	cell	cell	NOUN
ijpds-4459	395	3	-	-	PUNCT
ijpds-4459	395	4	targeted	target	VERB
ijpds-4459	395	5	delivery	delivery	NOUN
ijpds-4459	395	6	of	of	ADP
ijpds-4459	395	7	crispr	crispr	NOUN
ijpds-4459	395	8	/	/	SYM
ijpds-4459	395	9	cas9	cas9	NOUN
ijpds-4459	395	10	by	by	ADP
ijpds-4459	395	11	aptamer	aptamer	NOUN
ijpds-4459	395	12	-	-	PUNCT
ijpds-4459	395	13	functionalized	functionalize	VERB
ijpds-4459	395	14	lipopolymer	lipopolymer	NOUN
ijpds-4459	395	15	for	for	ADP
ijpds-4459	395	16	therapeutic	therapeutic	ADJ
ijpds-4459	395	17	genome	genome	NOUN
ijpds-4459	395	18	editing	editing	NOUN
ijpds-4459	395	19	of	of	ADP
ijpds-4459	395	20	vegfa	vegfa	PROPN
ijpds-4459	395	21	in	in	ADP
ijpds-4459	395	22	osteosarcoma	osteosarcoma	NOUN
ijpds-4459	395	23	.	.	PUNCT
ijpds-4459	396	1	biomaterials	biomaterial	NOUN
ijpds-4459	396	2	.	.	PUNCT
ijpds-4459	397	1	2017	2017	NUM
ijpds-4459	397	2	;	;	PUNCT
ijpds-4459	398	1	147:68–85	147:68–85	X
ijpds-4459	398	2	.	.	PROPN
ijpds-4459	398	3	44	44	NUM
ijpds-4459	398	4	.	.	PUNCT
ijpds-4459	399	1	duan	duan	PROPN
ijpds-4459	399	2	l	l	PROPN
ijpds-4459	399	3	,	,	PUNCT
ijpds-4459	399	4	ouyang	ouyang	PROPN
ijpds-4459	399	5	k	k	PROPN
ijpds-4459	399	6	,	,	PUNCT
ijpds-4459	399	7	xu	xu	PROPN
ijpds-4459	400	1	x	x	PROPN
ijpds-4459	400	2	,	,	PUNCT
ijpds-4459	400	3	et	et	PROPN
ijpds-4459	400	4	al	al	PROPN
ijpds-4459	400	5	.	.	PROPN
ijpds-4459	400	6	nanoparticle	nanoparticle	PROPN
ijpds-4459	400	7	delivery	delivery	NOUN
ijpds-4459	400	8	of	of	ADP
ijpds-4459	400	9	crispr	crispr	NOUN
ijpds-4459	400	10	/	/	SYM
ijpds-4459	400	11	cas9	cas9	NOUN
ijpds-4459	400	12	for	for	ADP
ijpds-4459	400	13	genome	genome	NOUN
ijpds-4459	400	14	editing	editing	NOUN
ijpds-4459	400	15	.	.	PUNCT
ijpds-4459	401	1	front	front	ADJ
ijpds-4459	401	2	genet	genet	PROPN
ijpds-4459	401	3	.	.	PUNCT
ijpds-4459	402	1	2021	2021	NUM
ijpds-4459	402	2	;	;	PUNCT
ijpds-4459	402	3	12	12	NUM
ijpds-4459	402	4	.	.	PUNCT
ijpds-4459	402	5	available	available	ADJ
ijpds-4459	402	6	from	from	ADP
ijpds-4459	402	7	:	:	PUNCT
ijpds-4459	402	8	https://doi.org/10.3389/fgene.2021.673286	https://doi.org/10.3389/fgene.2021.673286	ADJ
ijpds-4459	402	9	.	.	NOUN
ijpds-4459	402	10	45	45	NUM
ijpds-4459	402	11	.	.	PUNCT
ijpds-4459	403	1	iqbal	iqbal	PROPN
ijpds-4459	403	2	z	z	PROPN
ijpds-4459	403	3	,	,	PUNCT
ijpds-4459	403	4	rehman	rehman	PROPN
ijpds-4459	403	5	k	k	PROPN
ijpds-4459	403	6	,	,	PUNCT
ijpds-4459	403	7	xia	xia	PROPN
ijpds-4459	403	8	j	j	PROPN
ijpds-4459	403	9	,	,	PUNCT
ijpds-4459	403	10	et	et	PROPN
ijpds-4459	403	11	al	al	PROPN
ijpds-4459	403	12	.	.	PUNCT
ijpds-4459	403	13	biomaterial	biomaterial	ADJ
ijpds-4459	403	14	-	-	PUNCT
ijpds-4459	403	15	assisted	assist	VERB
ijpds-4459	403	16	targeted	targeted	ADJ
ijpds-4459	403	17	and	and	CCONJ
ijpds-4459	403	18	controlled	control	VERB
ijpds-4459	403	19	delivery	delivery	NOUN
ijpds-4459	403	20	of	of	ADP
ijpds-4459	403	21	crispr	crispr	NOUN
ijpds-4459	403	22	/	/	SYM
ijpds-4459	403	23	cas9	cas9	NOUN
ijpds-4459	403	24	for	for	ADP
ijpds-4459	403	25	precise	precise	ADJ
ijpds-4459	403	26	gene	gene	NOUN
ijpds-4459	403	27	editing	editing	NOUN
ijpds-4459	403	28	.	.	PUNCT
ijpds-4459	404	1	biomater	biomater	PROPN
ijpds-4459	404	2	sci	sci	PROPN
ijpds-4459	404	3	.	.	PROPN
ijpds-4459	404	4	2023	2023	NUM
ijpds-4459	404	5	;	;	PUNCT
ijpds-4459	404	6	11(11):3762–83	11(11):3762–83	NUM
ijpds-4459	404	7	.	.	X
ijpds-4459	405	1	46	46	NUM
ijpds-4459	405	2	.	.	PUNCT
ijpds-4459	406	1	yin	yin	PROPN
ijpds-4459	406	2	x	x	X
ijpds-4459	406	3	,	,	PUNCT
ijpds-4459	406	4	harmancey	harmancey	PROPN
ijpds-4459	406	5	r	r	PROPN
ijpds-4459	406	6	,	,	PUNCT
ijpds-4459	406	7	mcpherson	mcpherson	PROPN
ijpds-4459	406	8	dd	dd	PROPN
ijpds-4459	406	9	,	,	PUNCT
ijpds-4459	406	10	et	et	PROPN
ijpds-4459	406	11	al	al	PROPN
ijpds-4459	406	12	.	.	PROPN
ijpds-4459	406	13	liposome	liposome	NOUN
ijpds-4459	406	14	-	-	PUNCT
ijpds-4459	406	15	based	base	VERB
ijpds-4459	406	16	carriers	carrier	NOUN
ijpds-4459	406	17	for	for	ADP
ijpds-4459	406	18	crispr	crispr	ADJ
ijpds-4459	406	19	genome	genome	NOUN
ijpds-4459	406	20	editing	editing	NOUN
ijpds-4459	406	21	.	.	PUNCT
ijpds-4459	407	1	int	int	PROPN
ijpds-4459	407	2	j	j	PROPN
ijpds-4459	407	3	mol	mol	ADP
ijpds-4459	407	4	sci	sci	PROPN
ijpds-4459	407	5	.	.	PROPN
ijpds-4459	407	6	2023	2023	NUM
ijpds-4459	407	7	;	;	PUNCT
ijpds-4459	407	8	24(16):12844	24(16):12844	NUM
ijpds-4459	407	9	.	.	PROPN
ijpds-4459	407	10	47	47	NUM
ijpds-4459	407	11	.	.	PUNCT
ijpds-4459	408	1	nsairat	nsairat	PROPN
ijpds-4459	408	2	h	h	PROPN
ijpds-4459	408	3	,	,	PUNCT
ijpds-4459	408	4	khater	khater	NOUN
ijpds-4459	408	5	d	d	PROPN
ijpds-4459	408	6	,	,	PUNCT
ijpds-4459	408	7	sayed	say	VERB
ijpds-4459	408	8	u	u	PROPN
ijpds-4459	408	9	,	,	PUNCT
ijpds-4459	408	10	et	et	PROPN
ijpds-4459	408	11	al	al	PROPN
ijpds-4459	408	12	.	.	PUNCT
ijpds-4459	408	13	liposomes	liposome	NOUN
ijpds-4459	408	14	:	:	PUNCT
ijpds-4459	408	15	structure	structure	NOUN
ijpds-4459	408	16	,	,	PUNCT
ijpds-4459	408	17	composition	composition	NOUN
ijpds-4459	408	18	,	,	PUNCT
ijpds-4459	408	19	types	type	NOUN
ijpds-4459	408	20	,	,	PUNCT
ijpds-4459	408	21	and	and	CCONJ
ijpds-4459	408	22	clinical	clinical	ADJ
ijpds-4459	408	23	applications	application	NOUN
ijpds-4459	408	24	.	.	PUNCT
ijpds-4459	409	1	heliyon	heliyon	NOUN
ijpds-4459	409	2	.	.	PUNCT
ijpds-4459	410	1	2022	2022	NUM
ijpds-4459	410	2	;	;	PUNCT
ijpds-4459	410	3	8(5):e09394	8(5):e09394	NUM
ijpds-4459	410	4	.	.	NOUN
ijpds-4459	410	5	48	48	NUM
ijpds-4459	410	6	.	.	PUNCT
ijpds-4459	411	1	wang	wang	PROPN
ijpds-4459	411	2	d	d	PROPN
ijpds-4459	411	3	,	,	PUNCT
ijpds-4459	411	4	tai	tai	PROPN
ijpds-4459	411	5	pwl	pwl	PROPN
ijpds-4459	411	6	,	,	PUNCT
ijpds-4459	411	7	gao	gao	PROPN
ijpds-4459	411	8	g.	g.	PROPN
ijpds-4459	411	9	adeno	adeno	PROPN
ijpds-4459	411	10	-	-	PUNCT
ijpds-4459	411	11	associated	associate	VERB
ijpds-4459	411	12	virus	virus	NOUN
ijpds-4459	411	13	vector	vector	NOUN
ijpds-4459	411	14	as	as	ADP
ijpds-4459	411	15	a	a	DET
ijpds-4459	411	16	platform	platform	NOUN
ijpds-4459	411	17	for	for	ADP
ijpds-4459	411	18	gene	gene	NOUN
ijpds-4459	411	19	therapy	therapy	NOUN
ijpds-4459	411	20	delivery	delivery	NOUN
ijpds-4459	411	21	.	.	PUNCT
ijpds-4459	412	1	nat	nat	PROPN
ijpds-4459	412	2	rev	rev	VERB
ijpds-4459	412	3	drug	drug	NOUN
ijpds-4459	412	4	discov	discov	NOUN
ijpds-4459	412	5	.	.	PUNCT
ijpds-4459	413	1	2019;18(5):358–78	2019;18(5):358–78	NUM
ijpds-4459	413	2	.	.	NOUN
ijpds-4459	413	3	49	49	NUM
ijpds-4459	413	4	.	.	PUNCT
ijpds-4459	414	1	zakrzewski	zakrzewski	PROPN
ijpds-4459	414	2	w	w	PROPN
ijpds-4459	414	3	,	,	PUNCT
ijpds-4459	414	4	dobrzyński	dobrzyński	VERB
ijpds-4459	414	5	m	m	PROPN
ijpds-4459	414	6	,	,	PUNCT
ijpds-4459	414	7	rybak	rybak	PROPN
ijpds-4459	414	8	z	z	PROPN
ijpds-4459	414	9	,	,	PUNCT
ijpds-4459	414	10	et	et	PROPN
ijpds-4459	414	11	al	al	PROPN
ijpds-4459	414	12	.	.	PROPN
ijpds-4459	415	1	stem	stem	NOUN
ijpds-4459	415	2	cells	cell	NOUN
ijpds-4459	415	3	:	:	PUNCT
ijpds-4459	416	1	past	past	ADJ
ijpds-4459	416	2	,	,	PUNCT
ijpds-4459	416	3	present	present	ADJ
ijpds-4459	416	4	,	,	PUNCT
ijpds-4459	416	5	and	and	CCONJ
ijpds-4459	416	6	future	future	NOUN
ijpds-4459	416	7	.	.	PUNCT
ijpds-4459	417	1	stem	stem	NOUN
ijpds-4459	417	2	cell	cell	NOUN
ijpds-4459	417	3	res	re	NOUN
ijpds-4459	417	4	ther	ther	ADV
ijpds-4459	417	5	.	.	PUNCT
ijpds-4459	418	1	2019;10(1	2019;10(1	NUM
ijpds-4459	418	2	)	)	PUNCT
ijpds-4459	418	3	.	.	PUNCT
ijpds-4459	419	1	available	available	ADJ
ijpds-4459	419	2	from	from	ADP
ijpds-4459	419	3	:	:	PUNCT
ijpds-4459	419	4	https://doi.org/10.1186/s13287-019-1165-5	https://doi.org/10.1186/s13287-019-1165-5	NUM
ijpds-4459	419	5	50	50	NUM
ijpds-4459	419	6	.	.	PUNCT
ijpds-4459	420	1	he	he	PRON
ijpds-4459	420	2	r	r	PROPN
ijpds-4459	420	3	,	,	PUNCT
ijpds-4459	420	4	weng	weng	PROPN
ijpds-4459	420	5	z	z	PROPN
ijpds-4459	420	6	,	,	PUNCT
ijpds-4459	420	7	liu	liu	PROPN
ijpds-4459	420	8	y	y	PROPN
ijpds-4459	420	9	,	,	PUNCT
ijpds-4459	420	10	et	et	PROPN
ijpds-4459	420	11	al	al	PROPN
ijpds-4459	420	12	.	.	PUNCT
ijpds-4459	420	13	application	application	NOUN
ijpds-4459	420	14	of	of	ADP
ijpds-4459	420	15	induced	induced	ADJ
ijpds-4459	420	16	pluripotent	pluripotent	ADJ
ijpds-4459	420	17	stem	stem	NOUN
ijpds-4459	420	18	cells	cell	NOUN
ijpds-4459	420	19	in	in	ADP
ijpds-4459	420	20	malignant	malignant	ADJ
ijpds-4459	420	21	solid	solid	ADJ
ijpds-4459	420	22	tumours	tumour	NOUN
ijpds-4459	420	23	.	.	PUNCT
ijpds-4459	421	1	stem	stem	NOUN
ijpds-4459	421	2	cell	cell	PROPN
ijpds-4459	421	3	rev	rev	PROPN
ijpds-4459	421	4	rep	rep	PROPN
ijpds-4459	421	5	.	.	PROPN
ijpds-4459	421	6	2023;19(8):2557–75	2023;19(8):2557–75	PROPN
ijpds-4459	421	7	.	.	PROPN
ijpds-4459	422	1	51	51	NUM
ijpds-4459	422	2	.	.	PUNCT
ijpds-4459	423	1	valenti	valenti	PROPN
ijpds-4459	423	2	mt	mt	PROPN
ijpds-4459	423	3	,	,	PUNCT
ijpds-4459	423	4	serena	serena	PROPN
ijpds-4459	423	5	m	m	PROPN
ijpds-4459	423	6	,	,	PUNCT
ijpds-4459	423	7	carbonare	carbonare	PROPN
ijpds-4459	423	8	ld	ld	PROPN
ijpds-4459	423	9	,	,	PUNCT
ijpds-4459	423	10	et	et	PROPN
ijpds-4459	423	11	al	al	PROPN
ijpds-4459	423	12	.	.	PROPN
ijpds-4459	423	13	crispr	crispr	PROPN
ijpds-4459	423	14	/	/	SYM
ijpds-4459	423	15	cas	cas	NOUN
ijpds-4459	423	16	system	system	NOUN
ijpds-4459	423	17	:	:	PUNCT
ijpds-4459	423	18	an	an	DET
ijpds-4459	423	19	emerging	emerge	VERB
ijpds-4459	423	20	technology	technology	NOUN
ijpds-4459	423	21	in	in	ADP
ijpds-4459	423	22	stem	stem	NOUN
ijpds-4459	423	23	cell	cell	NOUN
ijpds-4459	423	24	research	research	NOUN
ijpds-4459	423	25	.	.	PUNCT
ijpds-4459	424	1	world	world	PROPN
ijpds-4459	424	2	j	j	PROPN
ijpds-4459	424	3	stem	stem	NOUN
ijpds-4459	424	4	cells	cell	NOUN
ijpds-4459	424	5	.	.	PUNCT
ijpds-4459	425	1	2019	2019	NUM
ijpds-4459	425	2	;	;	PUNCT
ijpds-4459	426	1	11(11):937–56	11(11):937–56	X
ijpds-4459	426	2	.	.	PROPN
ijpds-4459	426	3	52	52	NUM
ijpds-4459	426	4	.	.	PUNCT
ijpds-4459	427	1	xu	xu	PROPN
ijpds-4459	427	2	cl	cl	PROPN
ijpds-4459	427	3	,	,	PUNCT
ijpds-4459	427	4	ruan	ruan	PROPN
ijpds-4459	427	5	mzc	mzc	PROPN
ijpds-4459	427	6	,	,	PUNCT
ijpds-4459	427	7	mahajan	mahajan	PROPN
ijpds-4459	427	8	vb	vb	PROPN
ijpds-4459	427	9	,	,	PUNCT
ijpds-4459	427	10	et	et	PROPN
ijpds-4459	427	11	al	al	PROPN
ijpds-4459	427	12	.	.	PROPN
ijpds-4459	427	13	viral	viral	ADJ
ijpds-4459	427	14	delivery	delivery	NOUN
ijpds-4459	427	15	systems	system	NOUN
ijpds-4459	427	16	for	for	ADP
ijpds-4459	427	17	crispr	crispr	NOUN
ijpds-4459	427	18	.	.	PUNCT
ijpds-4459	428	1	viruses	virus	NOUN
ijpds-4459	428	2	.	.	PUNCT
ijpds-4459	429	1	2019	2019	NUM
ijpds-4459	429	2	;	;	PUNCT
ijpds-4459	429	3	11(1):28	11(1):28	NUM
ijpds-4459	429	4	.	.	PUNCT
ijpds-4459	430	1	53	53	NUM
ijpds-4459	430	2	.	.	PUNCT
ijpds-4459	431	1	alshangiti	alshangiti	PROPN
ijpds-4459	431	2	dm	dm	PROPN
ijpds-4459	431	3	,	,	PUNCT
ijpds-4459	431	4	el	el	NOUN
ijpds-4459	431	5	-	-	PUNCT
ijpds-4459	431	6	damhougy	damhougy	PROPN
ijpds-4459	431	7	tk	tk	PROPN
ijpds-4459	431	8	,	,	PUNCT
ijpds-4459	431	9	zaher	zaher	PROPN
ijpds-4459	431	10	a	a	PROPN
ijpds-4459	431	11	,	,	PUNCT
ijpds-4459	431	12	et	et	PROPN
ijpds-4459	431	13	al	al	PROPN
ijpds-4459	431	14	.	.	PUNCT
ijpds-4459	431	15	revolutionizing	revolutionize	VERB
ijpds-4459	431	16	biomedicine	biomedicine	NOUN
ijpds-4459	431	17	:	:	PUNCT
ijpds-4459	431	18	advancements	advancement	NOUN
ijpds-4459	431	19	,	,	PUNCT
ijpds-4459	431	20	applications	application	NOUN
ijpds-4459	431	21	,	,	PUNCT
ijpds-4459	431	22	and	and	CCONJ
ijpds-4459	431	23	prospects	prospect	NOUN
ijpds-4459	431	24	of	of	ADP
ijpds-4459	431	25	nanocomposite	nanocomposite	PROPN
ijpds-4459	431	26	macromolecular	macromolecular	PROPN
ijpds-4459	431	27	carbohydrate	carbohydrate	NOUN
ijpds-4459	431	28	-	-	PUNCT
ijpds-4459	431	29	based	base	VERB
ijpds-4459	431	30	hydrogel	hydrogel	NOUN
ijpds-4459	431	31	biomaterials	biomaterial	NOUN
ijpds-4459	431	32	:	:	PUNCT
ijpds-4459	431	33	a	a	DET
ijpds-4459	431	34	review	review	NOUN
ijpds-4459	431	35	.	.	PUNCT
ijpds-4459	432	1	rsc	rsc	PROPN
ijpds-4459	432	2	adv	adv	PROPN
ijpds-4459	432	3	.	.	PROPN
ijpds-4459	432	4	2023	2023	NUM
ijpds-4459	432	5	;	;	PUNCT
ijpds-4459	432	6	13(50):35251–91	13(50):35251–91	NUM
ijpds-4459	432	7	.	.	PUNCT
ijpds-4459	433	1	54	54	NUM
ijpds-4459	433	2	.	.	PUNCT
ijpds-4459	433	3	sánchez	sánchez	NOUN
ijpds-4459	433	4	-	-	PUNCT
ijpds-4459	433	5	bodón	bodón	PROPN
ijpds-4459	433	6	j	j	PROPN
ijpds-4459	433	7	,	,	PUNCT
ijpds-4459	433	8	diaz	diaz	PROPN
ijpds-4459	433	9	-	-	PUNCT
ijpds-4459	433	10	galbarriatu	galbarriatu	PROPN
ijpds-4459	433	11	m	m	PROPN
ijpds-4459	433	12	,	,	PUNCT
ijpds-4459	433	13	pérez	pérez	NOUN
ijpds-4459	433	14	-	-	PUNCT
ijpds-4459	433	15	álvarez	álvarez	PROPN
ijpds-4459	433	16	l	l	PROPN
ijpds-4459	433	17	,	,	PUNCT
ijpds-4459	433	18	et	et	PROPN
ijpds-4459	433	19	al	al	PROPN
ijpds-4459	433	20	.	.	PUNCT
ijpds-4459	433	21	strategies	strategy	NOUN
ijpds-4459	433	22	to	to	PART
ijpds-4459	433	23	enhance	enhance	VERB
ijpds-4459	433	24	biomedical	biomedical	ADJ
ijpds-4459	433	25	device	device	NOUN
ijpds-4459	433	26	performance	performance	NOUN
ijpds-4459	433	27	and	and	CCONJ
ijpds-4459	433	28	safety	safety	NOUN
ijpds-4459	433	29	:	:	PUNCT
ijpds-4459	433	30	a	a	DET
ijpds-4459	433	31	comprehensive	comprehensive	ADJ
ijpds-4459	433	32	review	review	NOUN
ijpds-4459	433	33	.	.	PUNCT
ijpds-4459	434	1	coatings	coating	NOUN
ijpds-4459	434	2	.	.	PUNCT
ijpds-4459	435	1	2023	2023	NUM
ijpds-4459	435	2	;	;	PUNCT
ijpds-4459	435	3	13(12):1981	13(12):1981	NUM
ijpds-4459	435	4	.	.	NOUN
ijpds-4459	435	5	55	55	NUM
ijpds-4459	435	6	.	.	PUNCT
ijpds-4459	436	1	yousefpour	yousefpour	PRON
ijpds-4459	436	2	p	p	NOUN
ijpds-4459	436	3	,	,	PUNCT
ijpds-4459	436	4	ni	ni	PROPN
ijpds-4459	436	5	k	k	PROPN
ijpds-4459	436	6	,	,	PUNCT
ijpds-4459	436	7	irvine	irvine	PROPN
ijpds-4459	436	8	dj	dj	PROPN
ijpds-4459	436	9	.	.	PUNCT
ijpds-4459	436	10	engineered	engineer	VERB
ijpds-4459	436	11	biomaterials	biomaterial	NOUN
ijpds-4459	436	12	for	for	ADP
ijpds-4459	436	13	targeted	target	VERB
ijpds-4459	436	14	modulation	modulation	NOUN
ijpds-4459	436	15	of	of	ADP
ijpds-4459	436	16	immune	immune	ADJ
ijpds-4459	436	17	cells	cell	NOUN
ijpds-4459	436	18	and	and	CCONJ
ijpds-4459	436	19	tissues	tissue	NOUN
ijpds-4459	436	20	.	.	PUNCT
ijpds-4459	437	1	nat	nat	PROPN
ijpds-4459	437	2	.	.	PUNCT
ijpds-4459	438	1	rev	rev	PROPN
ijpds-4459	438	2	.	.	PROPN
ijpds-4459	438	3	bioeng	bioeng	PROPN
ijpds-4459	438	4	.	.	PROPN
ijpds-4459	439	1	2023	2023	NUM
ijpds-4459	439	2	jan	jan	PROPN
ijpds-4459	439	3	30;1(2):107–24	30;1(2):107–24	NUM
ijpds-4459	439	4	.	.	PROPN
ijpds-4459	440	1	56	56	NUM
ijpds-4459	440	2	.	.	PUNCT
ijpds-4459	441	1	lewis	lewis	PROPN
ijpds-4459	441	2	js	js	PROPN
ijpds-4459	441	3	,	,	PUNCT
ijpds-4459	441	4	roy	roy	PROPN
ijpds-4459	441	5	k	k	PROPN
ijpds-4459	441	6	,	,	PUNCT
ijpds-4459	441	7	keselowsky	keselowsky	PROPN
ijpds-4459	441	8	bg	bg	PROPN
ijpds-4459	441	9	.	.	PUNCT
ijpds-4459	441	10	materials	material	NOUN
ijpds-4459	441	11	that	that	PRON
ijpds-4459	441	12	harness	harness	NOUN
ijpds-4459	441	13	and	and	CCONJ
ijpds-4459	441	14	modulate	modulate	VERB
ijpds-4459	441	15	the	the	DET
ijpds-4459	441	16	immune	immune	ADJ
ijpds-4459	441	17	system	system	NOUN
ijpds-4459	441	18	.	.	PUNCT
ijpds-4459	442	1	mrs	mrs	PROPN
ijpds-4459	442	2	bull	bull	PROPN
ijpds-4459	442	3	.	.	PUNCT
ijpds-4459	442	4	2014	2014	NUM
ijpds-4459	442	5	;	;	PUNCT
ijpds-4459	442	6	39(1):25–34	39(1):25–34	NUM
ijpds-4459	442	7	.	.	NOUN
ijpds-4459	442	8	57	57	NUM
ijpds-4459	442	9	.	.	PUNCT
ijpds-4459	443	1	han	han	PROPN
ijpds-4459	443	2	x	x	PROPN
ijpds-4459	443	3	,	,	PUNCT
ijpds-4459	443	4	alu	alu	PROPN
ijpds-4459	443	5	a	a	PROPN
ijpds-4459	443	6	,	,	PUNCT
ijpds-4459	443	7	liu	liu	PROPN
ijpds-4459	443	8	h	h	PROPN
ijpds-4459	443	9	,	,	PUNCT
ijpds-4459	443	10	et	et	PROPN
ijpds-4459	443	11	al	al	PROPN
ijpds-4459	443	12	.	.	PUNCT
ijpds-4459	443	13	biomaterial	biomaterial	ADJ
ijpds-4459	443	14	-	-	PUNCT
ijpds-4459	443	15	assisted	assist	VERB
ijpds-4459	443	16	biotherapy	biotherapy	NOUN
ijpds-4459	443	17	:	:	PUNCT
ijpds-4459	443	18	a	a	DET
ijpds-4459	443	19	brief	brief	ADJ
ijpds-4459	443	20	review	review	NOUN
ijpds-4459	443	21	of	of	ADP
ijpds-4459	443	22	biomaterials	biomaterial	NOUN
ijpds-4459	443	23	used	use	VERB
ijpds-4459	443	24	in	in	ADP
ijpds-4459	443	25	drug	drug	NOUN
ijpds-4459	443	26	delivery	delivery	NOUN
ijpds-4459	443	27	,	,	PUNCT
ijpds-4459	443	28	vaccine	vaccine	NOUN
ijpds-4459	443	29	development	development	NOUN
ijpds-4459	443	30	,	,	PUNCT
ijpds-4459	443	31	gene	gene	NOUN
ijpds-4459	443	32	therapy	therapy	NOUN
ijpds-4459	443	33	,	,	PUNCT
ijpds-4459	443	34	and	and	CCONJ
ijpds-4459	443	35	stem	stem	NOUN
ijpds-4459	443	36	cell	cell	NOUN
ijpds-4459	443	37	therapy	therapy	NOUN
ijpds-4459	443	38	.	.	PUNCT
ijpds-4459	444	1	bioact	bioact	PROPN
ijpds-4459	444	2	.	.	PUNCT
ijpds-4459	445	1	mater	mater	NOUN
ijpds-4459	445	2	.	.	PUNCT
ijpds-4459	446	1	2022	2022	NUM
ijpds-4459	446	2	;	;	PUNCT
ijpds-4459	447	1	17:29–48	17:29–48	NUM
ijpds-4459	447	2	.	.	PUNCT
ijpds-4459	448	1	58	58	NUM
ijpds-4459	448	2	.	.	PUNCT
ijpds-4459	449	1	mariani	mariani	PROPN
ijpds-4459	449	2	e	e	PROPN
ijpds-4459	449	3	,	,	PUNCT
ijpds-4459	449	4	lisignoli	lisignoli	NOUN
ijpds-4459	449	5	g	g	PROPN
ijpds-4459	449	6	,	,	PUNCT
ijpds-4459	449	7	borzì	borzì	PROPN
ijpds-4459	449	8	rm	rm	PROPN
ijpds-4459	449	9	,	,	PUNCT
ijpds-4459	449	10	et	et	PROPN
ijpds-4459	449	11	al	al	PROPN
ijpds-4459	449	12	.	.	PROPN
ijpds-4459	449	13	biomaterials	biomaterial	NOUN
ijpds-4459	449	14	:	:	PUNCT
ijpds-4459	449	15	foreign	foreign	ADJ
ijpds-4459	449	16	bodies	body	NOUN
ijpds-4459	449	17	or	or	CCONJ
ijpds-4459	449	18	tuners	tuner	NOUN
ijpds-4459	449	19	for	for	ADP
ijpds-4459	449	20	the	the	DET
ijpds-4459	449	21	immune	immune	ADJ
ijpds-4459	449	22	response	response	NOUN
ijpds-4459	449	23	?	?	PUNCT
ijpds-4459	450	1	int	int	NOUN
ijpds-4459	450	2	.	.	PUNCT
ijpds-4459	451	1	j.	j.	PROPN
ijpds-4459	451	2	mol	mol	PROPN
ijpds-4459	451	3	.	.	PUNCT
ijpds-4459	452	1	sci	sci	PROPN
ijpds-4459	452	2	.	.	PROPN
ijpds-4459	452	3	2019	2019	NUM
ijpds-4459	452	4	;	;	PUNCT
ijpds-4459	452	5	20(3):636	20(3):636	NUM
ijpds-4459	452	6	.	.	PUNCT
ijpds-4459	453	1	59	59	NUM
ijpds-4459	453	2	.	.	PUNCT
ijpds-4459	454	1	naeem	naeem	PROPN
ijpds-4459	454	2	m	m	PROPN
ijpds-4459	454	3	,	,	PUNCT
ijpds-4459	454	4	majeed	majeed	PROPN
ijpds-4459	454	5	s	s	PROPN
ijpds-4459	454	6	,	,	PUNCT
ijpds-4459	454	7	hoque	hoque	NOUN
ijpds-4459	454	8	mz	mz	PROPN
ijpds-4459	454	9	,	,	PUNCT
ijpds-4459	454	10	et	et	PROPN
ijpds-4459	454	11	al	al	PROPN
ijpds-4459	454	12	.	.	PROPN
ijpds-4459	455	1	latest	late	ADJ
ijpds-4459	455	2	developed	develop	VERB
ijpds-4459	455	3	strategies	strategy	NOUN
ijpds-4459	455	4	to	to	PART
ijpds-4459	455	5	minimize	minimize	VERB
ijpds-4459	455	6	the	the	DET
ijpds-4459	455	7	off	off	ADP
ijpds-4459	455	8	-	-	PUNCT
ijpds-4459	455	9	target	target	NOUN
ijpds-4459	455	10	effects	effect	NOUN
ijpds-4459	455	11	in	in	ADP
ijpds-4459	455	12	crispr	crispr	NOUN
ijpds-4459	455	13	-	-	PUNCT
ijpds-4459	455	14	casmediated	casmediate	VERB
ijpds-4459	455	15	genome	genome	NOUN
ijpds-4459	455	16	editing	editing	NOUN
ijpds-4459	455	17	.	.	PUNCT
ijpds-4459	456	1	cells	cell	NOUN
ijpds-4459	456	2	.	.	PUNCT
ijpds-4459	457	1	2020	2020	NUM
ijpds-4459	457	2	;	;	PUNCT
ijpds-4459	458	1	9(7):1608	9(7):1608	NOUN
ijpds-4459	458	2	.	.	PUNCT
ijpds-4459	459	1	60	60	NUM
ijpds-4459	459	2	.	.	PUNCT
ijpds-4459	460	1	guo	guo	PROPN
ijpds-4459	460	2	c	c	PROPN
ijpds-4459	460	3	,	,	PUNCT
ijpds-4459	460	4	ma	ma	PROPN
ijpds-4459	460	5	x	x	PROPN
ijpds-4459	460	6	,	,	PUNCT
ijpds-4459	460	7	gao	gao	PROPN
ijpds-4459	460	8	f	f	PROPN
ijpds-4459	460	9	,	,	PUNCT
ijpds-4459	460	10	et	et	PROPN
ijpds-4459	460	11	al	al	PROPN
ijpds-4459	460	12	.	.	PROPN
ijpds-4459	460	13	off	off	ADP
ijpds-4459	460	14	-	-	PUNCT
ijpds-4459	460	15	target	target	NOUN
ijpds-4459	460	16	effects	effect	NOUN
ijpds-4459	460	17	in	in	ADP
ijpds-4459	460	18	crispr	crispr	ADJ
ijpds-4459	460	19	/	/	SYM
ijpds-4459	460	20	cas9	cas9	NOUN
ijpds-4459	460	21	gene	gene	NOUN
ijpds-4459	460	22	editing	edit	VERB
ijpds-4459	460	23	.	.	PUNCT
ijpds-4459	461	1	front	front	NOUN
ijpds-4459	461	2	.	.	PUNCT
ijpds-4459	462	1	bioeng	bioeng	PROPN
ijpds-4459	462	2	.	.	PUNCT
ijpds-4459	462	3	biotechnol	biotechnol	PROPN
ijpds-4459	462	4	.	.	PUNCT
ijpds-4459	463	1	2023	2023	NUM
ijpds-4459	463	2	;	;	PUNCT
ijpds-4459	463	3	11:1143157	11:1143157	NUM
ijpds-4459	463	4	.	.	PROPN
ijpds-4459	463	5	61	61	NUM
ijpds-4459	463	6	.	.	PUNCT
ijpds-4459	464	1	zhang	zhang	PROPN
ijpds-4459	464	2	xh	xh	PROPN
ijpds-4459	464	3	,	,	PUNCT
ijpds-4459	464	4	tee	tee	NOUN
ijpds-4459	464	5	ly	ly	NOUN
ijpds-4459	464	6	,	,	PUNCT
ijpds-4459	464	7	wang	wang	PROPN
ijpds-4459	464	8	xg	xg	PROPN
ijpds-4459	464	9	,	,	PUNCT
ijpds-4459	464	10	et	et	PROPN
ijpds-4459	464	11	al	al	PROPN
ijpds-4459	464	12	.	.	PROPN
ijpds-4459	464	13	off	off	ADP
ijpds-4459	464	14	-	-	PUNCT
ijpds-4459	464	15	target	target	NOUN
ijpds-4459	464	16	effects	effect	NOUN
ijpds-4459	464	17	in	in	ADP
ijpds-4459	464	18	crispr	crispr	ADJ
ijpds-4459	464	19	/	/	SYM
ijpds-4459	464	20	cas9	cas9	NOUN
ijpds-4459	464	21	-	-	PUNCT
ijpds-4459	464	22	mediated	mediate	VERB
ijpds-4459	464	23	genome	genome	NOUN
ijpds-4459	464	24	engineering	engineering	NOUN
ijpds-4459	464	25	.	.	PUNCT
ijpds-4459	465	1	mol	mol	PROPN
ijpds-4459	465	2	.	.	PROPN
ijpds-4459	466	1	ther	ther	PROPN
ijpds-4459	466	2	.	.	PUNCT
ijpds-4459	467	1	nucleic	nucleic	ADJ
ijpds-4459	467	2	acids	acid	NOUN
ijpds-4459	467	3	.	.	PUNCT
ijpds-4459	468	1	2015	2015	NUM
ijpds-4459	468	2	;	;	PUNCT
ijpds-4459	468	3	4	4	NUM
ijpds-4459	468	4	:	:	PUNCT
ijpds-4459	468	5	e264	e264	PROPN
ijpds-4459	468	6	.	.	PROPN
ijpds-4459	469	1	62	62	NUM
ijpds-4459	469	2	.	.	PUNCT
ijpds-4459	470	1	ho	ho	PROPN
ijpds-4459	470	2	d	d	PROPN
ijpds-4459	470	3	,	,	PUNCT
ijpds-4459	470	4	quake	quake	PROPN
ijpds-4459	470	5	sr	sr	PROPN
ijpds-4459	470	6	,	,	PUNCT
ijpds-4459	470	7	mccabe	mccabe	PROPN
ijpds-4459	470	8	erb	erb	PROPN
ijpds-4459	470	9	,	,	PUNCT
ijpds-4459	470	10	et	et	PROPN
ijpds-4459	470	11	al	al	PROPN
ijpds-4459	470	12	.	.	PROPN
ijpds-4459	470	13	enabling	enable	VERB
ijpds-4459	470	14	technologies	technology	NOUN
ijpds-4459	470	15	for	for	ADP
ijpds-4459	470	16	personalized	personalized	ADJ
ijpds-4459	470	17	and	and	CCONJ
ijpds-4459	470	18	precision	precision	NOUN
ijpds-4459	470	19	medicine	medicine	NOUN
ijpds-4459	470	20	.	.	PUNCT
ijpds-4459	471	1	trends	trend	NOUN
ijpds-4459	471	2	biotechnol	biotechnol	VERB
ijpds-4459	471	3	.	.	PUNCT
ijpds-4459	472	1	2020	2020	NUM
ijpds-4459	472	2	;	;	PUNCT
ijpds-4459	473	1	38(5):497–518	38(5):497–518	NUM
ijpds-4459	473	2	.	.	PROPN
ijpds-4459	473	3	63	63	NUM
ijpds-4459	473	4	.	.	PUNCT
ijpds-4459	474	1	abdeen	abdeen	VERB
ijpds-4459	474	2	a	a	PRON
ijpds-4459	474	3	,	,	PUNCT
ijpds-4459	474	4	cosgrove	cosgrove	PROPN
ijpds-4459	474	5	b	b	PROPN
ijpds-4459	474	6	,	,	PUNCT
ijpds-4459	474	7	gersbach	gersbach	NOUN
ijpds-4459	474	8	c	c	NOUN
ijpds-4459	474	9	,	,	PUNCT
ijpds-4459	474	10	et	et	PROPN
ijpds-4459	474	11	al	al	PROPN
ijpds-4459	474	12	.	.	PUNCT
ijpds-4459	475	1	integrating	integrate	VERB
ijpds-4459	475	2	biomaterials	biomaterial	NOUN
ijpds-4459	475	3	and	and	CCONJ
ijpds-4459	475	4	genome	genome	NOUN
ijpds-4459	475	5	editing	editing	NOUN
ijpds-4459	475	6	approaches	approach	NOUN
ijpds-4459	475	7	to	to	PART
ijpds-4459	475	8	advance	advance	VERB
ijpds-4459	475	9	biomedical	biomedical	ADJ
ijpds-4459	475	10	science	science	NOUN
ijpds-4459	475	11	.	.	PUNCT
ijpds-4459	476	1	annu	annu	PROPN
ijpds-4459	476	2	.	.	PUNCT
ijpds-4459	477	1	rev	rev	AUX
ijpds-4459	477	2	biomed	biome	VERB
ijpds-4459	477	3	eng	eng	PROPN
ijpds-4459	477	4	.	.	PROPN
ijpds-4459	477	5	2021	2021	NUM
ijpds-4459	477	6	;	;	PUNCT
ijpds-4459	477	7	23(1):493	23(1):493	NUM
ijpds-4459	477	8	-	-	SYM
ijpds-4459	477	9	516	516	NUM
ijpds-4459	477	10	.	.	PUNCT
ijpds-4459	478	1	https://doi.org/10.1002/advs.202207512	https://doi.org/10.1002/advs.202207512	X
ijpds-4459	479	1	https://doi.org/10.3389/fgene.2021.673286	https://doi.org/10.3389/fgene.2021.673286	PROPN
ijpds-4459	479	2	https://doi.org/10.1186/s13287-019-1165-5	https://doi.org/10.1186/s13287-019-1165-5	NUM
ijpds-4459	479	3	bhat	bhat	PROPN
ijpds-4459	479	4	&	&	CCONJ
ijpds-4459	479	5	shanbhag	shanbhag	NOUN
ijpds-4459	479	6	biomaterials	biomaterial	NOUN
ijpds-4459	479	7	:	:	PUNCT
ijpds-4459	479	8	revolutionizing	revolutionize	VERB
ijpds-4459	479	9	cancer	cancer	NOUN
ijpds-4459	479	10	immunotherapy	immunotherapy	NOUN
ijpds-4459	479	11	and	and	CCONJ
ijpds-4459	479	12	genomics	genomics	NOUN
ijpds-4459	479	13	vol	vol	NOUN
ijpds-4459	479	14	3	3	NUM
ijpds-4459	479	15	|	|	NOUN
ijpds-4459	479	16	issue	issue	NOUN
ijpds-4459	479	17	2	2	NUM
ijpds-4459	479	18	|	|	ADV
ijpds-4459	479	19	apr	apr	NOUN
ijpds-4459	479	20	–	–	PUNCT
ijpds-4459	479	21	jun	jun	PROPN
ijpds-4459	479	22	2024	2024	NUM
ijpds-4459	479	23	indian	indian	PROPN
ijpds-4459	479	24	j	j	PROPN
ijpds-4459	479	25	pharm	pharm	PROPN
ijpds-4459	479	26	drug	drug	PROPN
ijpds-4459	479	27	studies	study	NOUN
ijpds-4459	479	28	|	|	ADV
ijpds-4459	479	29	45	45	NUM
ijpds-4459	479	30	64	64	NUM
ijpds-4459	479	31	.	.	PUNCT
ijpds-4459	480	1	dubey	dubey	PROPN
ijpds-4459	480	2	ak	ak	PROPN
ijpds-4459	480	3	,	,	PUNCT
ijpds-4459	480	4	mostafavi	mostafavi	PROPN
ijpds-4459	480	5	e.	e.	PROPN
ijpds-4459	480	6	biomaterials	biomaterials	PROPN
ijpds-4459	480	7	-	-	PUNCT
ijpds-4459	480	8	mediated	mediate	VERB
ijpds-4459	480	9	crispr	crispr	ADJ
ijpds-4459	480	10	/	/	SYM
ijpds-4459	480	11	cas9	cas9	NOUN
ijpds-4459	480	12	delivery	delivery	NOUN
ijpds-4459	480	13	:	:	PUNCT
ijpds-4459	480	14	recent	recent	ADJ
ijpds-4459	480	15	challenges	challenge	NOUN
ijpds-4459	480	16	and	and	CCONJ
ijpds-4459	480	17	opportunities	opportunity	NOUN
ijpds-4459	480	18	in	in	ADP
ijpds-4459	480	19	gene	gene	NOUN
ijpds-4459	480	20	therapy	therapy	NOUN
ijpds-4459	480	21	.	.	PUNCT
ijpds-4459	481	1	front	front	ADJ
ijpds-4459	481	2	chem	chem	NOUN
ijpds-4459	481	3	.	.	PUNCT
ijpds-4459	482	1	2023	2023	NUM
ijpds-4459	482	2	;	;	PUNCT
ijpds-4459	482	3	11	11	NUM
ijpds-4459	482	4	.	.	X
ijpds-4459	483	1	65	65	NUM
ijpds-4459	483	2	.	.	PUNCT
ijpds-4459	484	1	hasanzadeh	hasanzadeh	PROPN
ijpds-4459	484	2	a	a	X
ijpds-4459	484	3	,	,	PUNCT
ijpds-4459	484	4	ebadati	ebadati	PROPN
ijpds-4459	484	5	a	a	PROPN
ijpds-4459	484	6	,	,	PUNCT
ijpds-4459	484	7	dastanpour	dastanpour	PROPN
ijpds-4459	484	8	l	l	PROPN
ijpds-4459	484	9	,	,	PUNCT
ijpds-4459	484	10	et	et	PROPN
ijpds-4459	484	11	al	al	PROPN
ijpds-4459	484	12	.	.	PUNCT
ijpds-4459	485	1	applications	application	NOUN
ijpds-4459	485	2	of	of	ADP
ijpds-4459	485	3	innovation	innovation	NOUN
ijpds-4459	485	4	technologies	technology	NOUN
ijpds-4459	485	5	for	for	ADP
ijpds-4459	485	6	personalized	personalized	ADJ
ijpds-4459	485	7	cancer	cancer	NOUN
ijpds-4459	485	8	medicine	medicine	NOUN
ijpds-4459	485	9	:	:	PUNCT
ijpds-4459	485	10	stem	stem	NOUN
ijpds-4459	485	11	cells	cell	NOUN
ijpds-4459	485	12	and	and	CCONJ
ijpds-4459	485	13	gene	gene	NOUN
ijpds-4459	485	14	-	-	PUNCT
ijpds-4459	485	15	editing	edit	VERB
ijpds-4459	485	16	tools	tool	NOUN
ijpds-4459	485	17	.	.	PUNCT
ijpds-4459	486	1	acs	acs	PROPN
ijpds-4459	486	2	pharmacol	pharmacol	PROPN
ijpds-4459	486	3	.	.	PUNCT
ijpds-4459	487	1	transl	transl	PROPN
ijpds-4459	487	2	.	.	PUNCT
ijpds-4459	488	1	sci	sci	PROPN
ijpds-4459	488	2	.	.	PROPN
ijpds-4459	488	3	2023	2023	NUM
ijpds-4459	488	4	;	;	PUNCT
ijpds-4459	488	5	6(12):1758–79	6(12):1758–79	NUM
ijpds-4459	488	6	.	.	PUNCT
ijpds-4459	489	1	66	66	NUM
ijpds-4459	489	2	.	.	PUNCT
ijpds-4459	490	1	dai	dai	PROPN
ijpds-4459	490	2	x	x	PROPN
ijpds-4459	490	3	,	,	PUNCT
ijpds-4459	490	4	blancafort	blancafort	NOUN
ijpds-4459	490	5	p	p	NOUN
ijpds-4459	490	6	,	,	PUNCT
ijpds-4459	490	7	wang	wang	PROPN
ijpds-4459	490	8	p	p	PROPN
ijpds-4459	490	9	,	,	PUNCT
ijpds-4459	490	10	sgro	sgro	NOUN
ijpds-4459	490	11	a	a	X
ijpds-4459	490	12	,	,	PUNCT
ijpds-4459	490	13	thompson	thompson	PROPN
ijpds-4459	490	14	ew	ew	NOUN
ijpds-4459	490	15	,	,	PUNCT
ijpds-4459	490	16	ostrikov	ostrikov	PROPN
ijpds-4459	490	17	k	k	PROPN
ijpds-4459	490	18	(	(	PUNCT
ijpds-4459	490	19	ken	ken	PROPN
ijpds-4459	490	20	)	)	PUNCT
ijpds-4459	490	21	.	.	PUNCT
ijpds-4459	491	1	innovative	innovative	ADJ
ijpds-4459	491	2	precision	precision	NOUN
ijpds-4459	491	3	gene	gene	NOUN
ijpds-4459	491	4	-	-	PUNCT
ijpds-4459	491	5	editing	edit	VERB
ijpds-4459	491	6	tools	tool	NOUN
ijpds-4459	491	7	in	in	ADP
ijpds-4459	491	8	personalized	personalized	ADJ
ijpds-4459	491	9	cancer	cancer	NOUN
ijpds-4459	491	10	medicine	medicine	NOUN
ijpds-4459	491	11	.	.	PUNCT
ijpds-4459	492	1	adv	adv	PROPN
ijpds-4459	492	2	.	.	PUNCT
ijpds-4459	493	1	sci	sci	PROPN
ijpds-4459	493	2	.	.	PROPN
ijpds-4459	493	3	2020	2020	NUM
ijpds-4459	493	4	;	;	PUNCT
ijpds-4459	493	5	7(12	7(12	NUM
ijpds-4459	493	6	)	)	PUNCT
ijpds-4459	493	7	.	.	PUNCT
ijpds-4459	494	1	how	how	SCONJ
ijpds-4459	494	2	to	to	PART
ijpds-4459	494	3	cite	cite	VERB
ijpds-4459	494	4	this	this	DET
ijpds-4459	494	5	article	article	NOUN
ijpds-4459	494	6	:	:	PUNCT
ijpds-4459	494	7	ramdas	ramdas	PROPN
ijpds-4459	494	8	bhat1	bhat1	PROPN
ijpds-4459	494	9	,	,	PUNCT
ijpds-4459	494	10	preeti	preeti	PROPN
ijpds-4459	494	11	shanbhag	shanbhag	PROPN
ijpds-4459	494	12	.	.	PUNCT
ijpds-4459	495	1	emerging	emerge	VERB
ijpds-4459	495	2	trends	trend	NOUN
ijpds-4459	495	3	in	in	ADP
ijpds-4459	495	4	biomaterials	biomaterial	NOUN
ijpds-4459	495	5	for	for	ADP
ijpds-4459	495	6	cancer	cancer	NOUN
ijpds-4459	495	7	immunotherapy	immunotherapy	NOUN
ijpds-4459	495	8	and	and	CCONJ
ijpds-4459	495	9	genome	genome	NOUN
ijpds-4459	495	10	editing	editing	NOUN
ijpds-4459	495	11	:	:	PUNCT
ijpds-4459	495	12	a	a	DET
ijpds-4459	495	13	comprehensive	comprehensive	ADJ
ijpds-4459	495	14	review	review	NOUN
ijpds-4459	495	15	.	.	PUNCT
ijpds-4459	496	1	indian	indian	PROPN
ijpds-4459	496	2	j	j	PROPN
ijpds-4459	496	3	pharm	pharm	PROPN
ijpds-4459	496	4	drug	drug	PROPN
ijpds-4459	496	5	studies	study	NOUN
ijpds-4459	496	6	.	.	PUNCT
ijpds-4459	496	7	2024	2024	NUM
ijpds-4459	496	8	;	;	PUNCT
ijpds-4459	496	9	3(2):37	3(2):37	NUM
ijpds-4459	496	10	-	-	SYM
ijpds-4459	496	11	45	45	NUM
ijpds-4459	496	12	.	.	PUNCT
ijpds-4459	497	1	funding	funding	NOUN
ijpds-4459	497	2	:	:	PUNCT
ijpds-4459	497	3	none	none	NOUN
ijpds-4459	497	4	;	;	PUNCT
ijpds-4459	497	5	conflicts	conflict	NOUN
ijpds-4459	497	6	of	of	ADP
ijpds-4459	497	7	interest	interest	NOUN
ijpds-4459	497	8	:	:	PUNCT
ijpds-4459	497	9	none	none	NOUN
ijpds-4459	497	10	stated	state	VERB