id	sid	tid	token	lemma	pos
ijpds-4639	1	1	singha	singha	PROPN
ijpds-4639	1	2	et	et	PROPN
ijpds-4639	1	3	al	al	PROPN
ijpds-4639	1	4	.	.	PROPN
ijpds-4639	1	5	leptin	leptin	PROPN
ijpds-4639	1	6	:	:	PUNCT
ijpds-4639	1	7	its	its	PRON
ijpds-4639	1	8	crucial	crucial	ADJ
ijpds-4639	1	9	role	role	NOUN
ijpds-4639	1	10	in	in	ADP
ijpds-4639	1	11	the	the	DET
ijpds-4639	1	12	fight	fight	NOUN
ijpds-4639	1	13	against	against	ADP
ijpds-4639	1	14	obesity	obesity	NOUN
ijpds-4639	1	15	online	online	ADJ
ijpds-4639	1	16	first	first	PROPN
ijpds-4639	1	17	indian	indian	PROPN
ijpds-4639	1	18	j	j	PROPN
ijpds-4639	1	19	pharm	pharm	PROPN
ijpds-4639	1	20	drug	drug	PROPN
ijpds-4639	1	21	studies	study	NOUN
ijpds-4639	1	22	|	|	ADV
ijpds-4639	1	23	1	1	NUM
ijpds-4639	1	24	review	review	NOUN
ijpds-4639	1	25	article	article	NOUN
ijpds-4639	1	26	decoding	decode	VERB
ijpds-4639	1	27	leptin	leptin	NOUN
ijpds-4639	1	28	:	:	PUNCT
ijpds-4639	1	29	unraveling	unravel	VERB
ijpds-4639	1	30	the	the	DET
ijpds-4639	1	31	role	role	NOUN
ijpds-4639	1	32	of	of	ADP
ijpds-4639	1	33	leptin	leptin	NOUN
ijpds-4639	1	34	signaling	signal	VERB
ijpds-4639	1	35	in	in	ADP
ijpds-4639	1	36	the	the	DET
ijpds-4639	1	37	battle	battle	NOUN
ijpds-4639	1	38	against	against	ADP
ijpds-4639	1	39	obesity	obesity	NOUN
ijpds-4639	1	40	soumyadip	soumyadip	ADJ
ijpds-4639	1	41	singha1	singha1	PROPN
ijpds-4639	1	42	,	,	PUNCT
ijpds-4639	1	43	soumyadip	soumyadip	VERB
ijpds-4639	1	44	nayak2	nayak2	PROPN
ijpds-4639	1	45	,	,	PUNCT
ijpds-4639	1	46	rahul	rahul	PROPN
ijpds-4639	1	47	bishayee2	bishayee2	PROPN
ijpds-4639	1	48	,	,	PUNCT
ijpds-4639	1	49	pritam	pritam	PROPN
ijpds-4639	1	50	sarkar3	sarkar3	PROPN
ijpds-4639	1	51	,	,	PUNCT
ijpds-4639	1	52	priyanka	priyanka	PROPN
ijpds-4639	1	53	ghosh3	ghosh3	PROPN
ijpds-4639	1	54	,	,	PUNCT
ijpds-4639	1	55	udita	udita	PROPN
ijpds-4639	1	56	dutta4	dutta4	NOUN
ijpds-4639	1	57	,	,	PUNCT
ijpds-4639	1	58	poulomi	poulomi	X
ijpds-4639	1	59	mishra5	mishra5	NOUN
ijpds-4639	1	60	from	from	ADP
ijpds-4639	1	61	,	,	PUNCT
ijpds-4639	1	62	1lecturer	1lecturer	NUM
ijpds-4639	1	63	,	,	PUNCT
ijpds-4639	1	64	pandaveswar	pandaveswar	ADJ
ijpds-4639	1	65	school	school	NOUN
ijpds-4639	1	66	of	of	ADP
ijpds-4639	1	67	pharmacy	pharmacy	NOUN
ijpds-4639	1	68	,	,	PUNCT
ijpds-4639	1	69	pandaveswar	pandaveswar	NOUN
ijpds-4639	1	70	,	,	PUNCT
ijpds-4639	1	71	west	west	PROPN
ijpds-4639	1	72	bengal	bengal	PROPN
ijpds-4639	1	73	,	,	PUNCT
ijpds-4639	1	74	india	india	PROPN
ijpds-4639	1	75	,	,	PUNCT
ijpds-4639	1	76	2pg	2pg	ADJ
ijpds-4639	1	77	student	student	NOUN
ijpds-4639	1	78	,	,	PUNCT
ijpds-4639	1	79	department	department	NOUN
ijpds-4639	1	80	of	of	ADP
ijpds-4639	1	81	pharmacology	pharmacology	NOUN
ijpds-4639	1	82	,	,	PUNCT
ijpds-4639	1	83	school	school	NOUN
ijpds-4639	1	84	of	of	ADP
ijpds-4639	1	85	pharmaceutical	pharmaceutical	NOUN
ijpds-4639	1	86	sciences	science	NOUN
ijpds-4639	1	87	,	,	PUNCT
ijpds-4639	1	88	lovely	lovely	ADJ
ijpds-4639	1	89	professional	professional	ADJ
ijpds-4639	1	90	university	university	NOUN
ijpds-4639	1	91	,	,	PUNCT
ijpds-4639	1	92	phagwara	phagwara	ADJ
ijpds-4639	1	93	,	,	PUNCT
ijpds-4639	1	94	punjab	punjab	PROPN
ijpds-4639	1	95	,	,	PUNCT
ijpds-4639	1	96	india	india	PROPN
ijpds-4639	1	97	,	,	PUNCT
ijpds-4639	1	98	3ug	3ug	ADJ
ijpds-4639	1	99	student	student	NOUN
ijpds-4639	1	100	,	,	PUNCT
ijpds-4639	1	101	department	department	NOUN
ijpds-4639	1	102	of	of	ADP
ijpds-4639	1	103	pharmacy	pharmacy	NOUN
ijpds-4639	1	104	,	,	PUNCT
ijpds-4639	1	105	school	school	NOUN
ijpds-4639	1	106	of	of	ADP
ijpds-4639	1	107	pharmacy	pharmacy	NOUN
ijpds-4639	1	108	,	,	PUNCT
ijpds-4639	1	109	seacom	seacom	PROPN
ijpds-4639	1	110	skills	skill	VERB
ijpds-4639	1	111	university	university	NOUN
ijpds-4639	1	112	,	,	PUNCT
ijpds-4639	1	113	bolpur	bolpur	PROPN
ijpds-4639	1	114	,	,	PUNCT
ijpds-4639	1	115	west	west	PROPN
ijpds-4639	1	116	bengal	bengal	PROPN
ijpds-4639	1	117	,	,	PUNCT
ijpds-4639	1	118	india	india	PROPN
ijpds-4639	1	119	,	,	PUNCT
ijpds-4639	1	120	4ug	4ug	ADJ
ijpds-4639	1	121	student	student	NOUN
ijpds-4639	1	122	,	,	PUNCT
ijpds-4639	1	123	department	department	NOUN
ijpds-4639	1	124	of	of	ADP
ijpds-4639	1	125	pharmacy	pharmacy	NOUN
ijpds-4639	1	126	,	,	PUNCT
ijpds-4639	1	127	eminent	eminent	ADJ
ijpds-4639	1	128	college	college	NOUN
ijpds-4639	1	129	of	of	ADP
ijpds-4639	1	130	pharmaceutical	pharmaceutical	NOUN
ijpds-4639	1	131	technology	technology	NOUN
ijpds-4639	1	132	,	,	PUNCT
ijpds-4639	1	133	moshpukur	moshpukur	NOUN
ijpds-4639	1	134	,	,	PUNCT
ijpds-4639	1	135	barbaria	barbaria	NOUN
ijpds-4639	1	136	,	,	PUNCT
ijpds-4639	1	137	paschim	paschim	NOUN
ijpds-4639	1	138	khilkapur	khilkapur	NOUN
ijpds-4639	1	139	,	,	PUNCT
ijpds-4639	1	140	barasat	barasat	VERB
ijpds-4639	1	141	,	,	PUNCT
ijpds-4639	1	142	jagannathpur	jagannathpur	PROPN
ijpds-4639	1	143	,	,	PUNCT
ijpds-4639	1	144	west	west	PROPN
ijpds-4639	1	145	bengal	bengal	PROPN
ijpds-4639	1	146	,	,	PUNCT
ijpds-4639	1	147	india	india	PROPN
ijpds-4639	1	148	.	.	PUNCT
ijpds-4639	2	1	5assistant	5assistant	NUM
ijpds-4639	2	2	professor	professor	NOUN
ijpds-4639	2	3	,	,	PUNCT
ijpds-4639	2	4	pandaveswar	pandaveswar	ADJ
ijpds-4639	2	5	school	school	NOUN
ijpds-4639	2	6	of	of	ADP
ijpds-4639	2	7	pharmacy	pharmacy	NOUN
ijpds-4639	2	8	,	,	PUNCT
ijpds-4639	2	9	pandaveswar	pandaveswar	NOUN
ijpds-4639	2	10	,	,	PUNCT
ijpds-4639	2	11	west	west	PROPN
ijpds-4639	2	12	bengal	bengal	PROPN
ijpds-4639	2	13	,	,	PUNCT
ijpds-4639	2	14	india	india	PROPN
ijpds-4639	2	15	abstract	abstract	ADJ
ijpds-4639	2	16	obesity	obesity	NOUN
ijpds-4639	2	17	represents	represent	VERB
ijpds-4639	2	18	a	a	DET
ijpds-4639	2	19	major	major	ADJ
ijpds-4639	2	20	global	global	ADJ
ijpds-4639	2	21	health	health	NOUN
ijpds-4639	2	22	crisis	crisis	NOUN
ijpds-4639	2	23	,	,	PUNCT
ijpds-4639	2	24	linked	link	VERB
ijpds-4639	2	25	to	to	ADP
ijpds-4639	2	26	a	a	DET
ijpds-4639	2	27	spectrum	spectrum	NOUN
ijpds-4639	2	28	of	of	ADP
ijpds-4639	2	29	metabolic	metabolic	NOUN
ijpds-4639	2	30	disorders	disorder	NOUN
ijpds-4639	2	31	,	,	PUNCT
ijpds-4639	2	32	including	include	VERB
ijpds-4639	2	33	diabetes	diabetes	NOUN
ijpds-4639	2	34	,	,	PUNCT
ijpds-4639	2	35	cardiovascular	cardiovascular	ADJ
ijpds-4639	2	36	diseases	disease	NOUN
ijpds-4639	2	37	,	,	PUNCT
ijpds-4639	2	38	and	and	CCONJ
ijpds-4639	2	39	hypertension	hypertension	NOUN
ijpds-4639	2	40	.	.	PUNCT
ijpds-4639	3	1	leptin	leptin	PROPN
ijpds-4639	3	2	,	,	PUNCT
ijpds-4639	3	3	a	a	DET
ijpds-4639	3	4	hormone	hormone	NOUN
ijpds-4639	3	5	predominantly	predominantly	ADV
ijpds-4639	3	6	produced	produce	VERB
ijpds-4639	3	7	by	by	ADP
ijpds-4639	3	8	adipose	adipose	ADJ
ijpds-4639	3	9	tissue	tissue	NOUN
ijpds-4639	3	10	,	,	PUNCT
ijpds-4639	3	11	plays	play	VERB
ijpds-4639	3	12	a	a	DET
ijpds-4639	3	13	critical	critical	ADJ
ijpds-4639	3	14	role	role	NOUN
ijpds-4639	3	15	in	in	ADP
ijpds-4639	3	16	regulating	regulate	VERB
ijpds-4639	3	17	energy	energy	NOUN
ijpds-4639	3	18	balance	balance	NOUN
ijpds-4639	3	19	,	,	PUNCT
ijpds-4639	3	20	appetite	appetite	NOUN
ijpds-4639	3	21	,	,	PUNCT
ijpds-4639	3	22	and	and	CCONJ
ijpds-4639	3	23	metabolism	metabolism	NOUN
ijpds-4639	3	24	.	.	PUNCT
ijpds-4639	4	1	historically	historically	ADV
ijpds-4639	4	2	,	,	PUNCT
ijpds-4639	4	3	leptin	leptin	PROPN
ijpds-4639	4	4	was	be	AUX
ijpds-4639	4	5	believed	believe	VERB
ijpds-4639	4	6	to	to	PART
ijpds-4639	4	7	be	be	AUX
ijpds-4639	4	8	a	a	DET
ijpds-4639	4	9	cornerstone	cornerstone	NOUN
ijpds-4639	4	10	in	in	ADP
ijpds-4639	4	11	the	the	DET
ijpds-4639	4	12	management	management	NOUN
ijpds-4639	4	13	of	of	ADP
ijpds-4639	4	14	obesity	obesity	NOUN
ijpds-4639	4	15	due	due	ADP
ijpds-4639	4	16	to	to	ADP
ijpds-4639	4	17	its	its	PRON
ijpds-4639	4	18	ability	ability	NOUN
ijpds-4639	4	19	to	to	PART
ijpds-4639	4	20	suppress	suppress	VERB
ijpds-4639	4	21	appetite	appetite	NOUN
ijpds-4639	4	22	.	.	PUNCT
ijpds-4639	5	1	however	however	ADV
ijpds-4639	5	2	,	,	PUNCT
ijpds-4639	5	3	the	the	DET
ijpds-4639	5	4	effectiveness	effectiveness	NOUN
ijpds-4639	5	5	of	of	ADP
ijpds-4639	5	6	leptin	leptin	NOUN
ijpds-4639	5	7	therapy	therapy	NOUN
ijpds-4639	5	8	has	have	AUX
ijpds-4639	5	9	been	be	AUX
ijpds-4639	5	10	limited	limit	VERB
ijpds-4639	5	11	by	by	ADP
ijpds-4639	5	12	the	the	DET
ijpds-4639	5	13	phenomenon	phenomenon	NOUN
ijpds-4639	5	14	of	of	ADP
ijpds-4639	5	15	leptin	leptin	NOUN
ijpds-4639	5	16	resistance	resistance	NOUN
ijpds-4639	5	17	in	in	ADP
ijpds-4639	5	18	obese	obese	ADJ
ijpds-4639	5	19	individuals	individual	NOUN
ijpds-4639	5	20	.	.	PUNCT
ijpds-4639	6	1	this	this	DET
ijpds-4639	6	2	review	review	NOUN
ijpds-4639	6	3	,	,	PUNCT
ijpds-4639	6	4	titled	title	VERB
ijpds-4639	6	5	"	"	PUNCT
ijpds-4639	6	6	decoding	decode	VERB
ijpds-4639	6	7	leptin	leptin	NOUN
ijpds-4639	6	8	:	:	PUNCT
ijpds-4639	6	9	unraveling	unravel	VERB
ijpds-4639	6	10	the	the	DET
ijpds-4639	6	11	role	role	NOUN
ijpds-4639	6	12	of	of	ADP
ijpds-4639	6	13	leptin	leptin	NOUN
ijpds-4639	6	14	signaling	signal	VERB
ijpds-4639	6	15	in	in	ADP
ijpds-4639	6	16	the	the	DET
ijpds-4639	6	17	battle	battle	NOUN
ijpds-4639	6	18	against	against	ADP
ijpds-4639	6	19	obesity	obesity	NOUN
ijpds-4639	6	20	,	,	PUNCT
ijpds-4639	6	21	"	"	PUNCT
ijpds-4639	6	22	aims	aim	VERB
ijpds-4639	6	23	to	to	PART
ijpds-4639	6	24	delve	delve	VERB
ijpds-4639	6	25	into	into	ADP
ijpds-4639	6	26	the	the	DET
ijpds-4639	6	27	molecular	molecular	ADJ
ijpds-4639	6	28	intricacies	intricacy	NOUN
ijpds-4639	6	29	of	of	ADP
ijpds-4639	6	30	leptin	leptin	NOUN
ijpds-4639	6	31	signaling	signal	VERB
ijpds-4639	6	32	pathways	pathway	NOUN
ijpds-4639	6	33	and	and	CCONJ
ijpds-4639	6	34	their	their	PRON
ijpds-4639	6	35	implications	implication	NOUN
ijpds-4639	6	36	in	in	ADP
ijpds-4639	6	37	obesity	obesity	NOUN
ijpds-4639	6	38	management	management	NOUN
ijpds-4639	6	39	.	.	PUNCT
ijpds-4639	7	1	we	we	PRON
ijpds-4639	7	2	explore	explore	VERB
ijpds-4639	7	3	the	the	DET
ijpds-4639	7	4	mechanisms	mechanism	NOUN
ijpds-4639	7	5	underlying	underlie	VERB
ijpds-4639	7	6	leptin	leptin	NOUN
ijpds-4639	7	7	resistance	resistance	NOUN
ijpds-4639	7	8	,	,	PUNCT
ijpds-4639	7	9	the	the	DET
ijpds-4639	7	10	impact	impact	NOUN
ijpds-4639	7	11	of	of	ADP
ijpds-4639	7	12	leptin	leptin	NOUN
ijpds-4639	7	13	on	on	ADP
ijpds-4639	7	14	neuroendocrine	neuroendocrine	ADJ
ijpds-4639	7	15	pathways	pathway	NOUN
ijpds-4639	7	16	,	,	PUNCT
ijpds-4639	7	17	and	and	CCONJ
ijpds-4639	7	18	the	the	DET
ijpds-4639	7	19	potential	potential	NOUN
ijpds-4639	7	20	for	for	ADP
ijpds-4639	7	21	resetting	reset	VERB
ijpds-4639	7	22	leptin	leptin	NOUN
ijpds-4639	7	23	sensitivity	sensitivity	NOUN
ijpds-4639	7	24	as	as	ADP
ijpds-4639	7	25	a	a	DET
ijpds-4639	7	26	therapeutic	therapeutic	ADJ
ijpds-4639	7	27	strategy	strategy	NOUN
ijpds-4639	7	28	.	.	PUNCT
ijpds-4639	8	1	additionally	additionally	ADV
ijpds-4639	8	2	,	,	PUNCT
ijpds-4639	8	3	we	we	PRON
ijpds-4639	8	4	discuss	discuss	VERB
ijpds-4639	8	5	recent	recent	ADJ
ijpds-4639	8	6	advances	advance	NOUN
ijpds-4639	8	7	in	in	ADP
ijpds-4639	8	8	therapeutic	therapeutic	ADJ
ijpds-4639	8	9	approaches	approach	NOUN
ijpds-4639	8	10	aiming	aim	VERB
ijpds-4639	8	11	to	to	PART
ijpds-4639	8	12	enhance	enhance	VERB
ijpds-4639	8	13	leptin	leptin	NOUN
ijpds-4639	8	14	sensitivity	sensitivity	NOUN
ijpds-4639	8	15	or	or	CCONJ
ijpds-4639	8	16	mimic	mimic	VERB
ijpds-4639	8	17	its	its	PRON
ijpds-4639	8	18	effects	effect	NOUN
ijpds-4639	8	19	,	,	PUNCT
ijpds-4639	8	20	including	include	VERB
ijpds-4639	8	21	novel	novel	ADJ
ijpds-4639	8	22	pharmacological	pharmacological	ADJ
ijpds-4639	8	23	agents	agent	NOUN
ijpds-4639	8	24	and	and	CCONJ
ijpds-4639	8	25	lifestyle	lifestyle	NOUN
ijpds-4639	8	26	modifications	modification	NOUN
ijpds-4639	8	27	that	that	PRON
ijpds-4639	8	28	influence	influence	NOUN
ijpds-4639	8	29	leptin	leptin	VERB
ijpds-4639	8	30	signaling	signal	VERB
ijpds-4639	8	31	.	.	PUNCT
ijpds-4639	9	1	by	by	ADP
ijpds-4639	9	2	providing	provide	VERB
ijpds-4639	9	3	a	a	DET
ijpds-4639	9	4	comprehensive	comprehensive	ADJ
ijpds-4639	9	5	overview	overview	NOUN
ijpds-4639	9	6	of	of	ADP
ijpds-4639	9	7	current	current	ADJ
ijpds-4639	9	8	research	research	NOUN
ijpds-4639	9	9	and	and	CCONJ
ijpds-4639	9	10	emerging	emerge	VERB
ijpds-4639	9	11	therapies	therapy	NOUN
ijpds-4639	9	12	,	,	PUNCT
ijpds-4639	9	13	this	this	DET
ijpds-4639	9	14	review	review	NOUN
ijpds-4639	9	15	seeks	seek	VERB
ijpds-4639	9	16	to	to	PART
ijpds-4639	9	17	illuminate	illuminate	VERB
ijpds-4639	9	18	the	the	DET
ijpds-4639	9	19	path	path	NOUN
ijpds-4639	9	20	forward	forward	ADV
ijpds-4639	9	21	in	in	ADP
ijpds-4639	9	22	leveraging	leverage	VERB
ijpds-4639	9	23	leptin	leptin	NOUN
ijpds-4639	9	24	signaling	signal	VERB
ijpds-4639	9	25	for	for	ADP
ijpds-4639	9	26	more	more	ADV
ijpds-4639	9	27	effective	effective	ADJ
ijpds-4639	9	28	obesity	obesity	NOUN
ijpds-4639	9	29	interventions	intervention	NOUN
ijpds-4639	9	30	.	.	PUNCT
ijpds-4639	10	1	key	key	ADJ
ijpds-4639	10	2	words	word	NOUN
ijpds-4639	10	3	:	:	PUNCT
ijpds-4639	10	4	leptin	leptin	NOUN
ijpds-4639	10	5	resistance	resistance	NOUN
ijpds-4639	10	6	,	,	PUNCT
ijpds-4639	10	7	obesity	obesity	NOUN
ijpds-4639	10	8	management	management	NOUN
ijpds-4639	10	9	,	,	PUNCT
ijpds-4639	10	10	therapeutic	therapeutic	ADJ
ijpds-4639	10	11	strategies	strategy	NOUN
ijpds-4639	10	12	,	,	PUNCT
ijpds-4639	10	13	neuroendocrine	neuroendocrine	ADJ
ijpds-4639	10	14	regulation	regulation	NOUN
ijpds-4639	10	15	besity	besity	NOUN
ijpds-4639	10	16	can	can	AUX
ijpds-4639	10	17	be	be	AUX
ijpds-4639	10	18	defined	define	VERB
ijpds-4639	10	19	as	as	ADP
ijpds-4639	10	20	a	a	DET
ijpds-4639	10	21	condition	condition	NOUN
ijpds-4639	10	22	which	which	PRON
ijpds-4639	10	23	can	can	AUX
ijpds-4639	10	24	be	be	AUX
ijpds-4639	10	25	characterized	characterize	VERB
ijpds-4639	10	26	by	by	ADP
ijpds-4639	10	27	excessive	excessive	ADJ
ijpds-4639	10	28	accumulation	accumulation	NOUN
ijpds-4639	10	29	of	of	ADP
ijpds-4639	10	30	body	body	NOUN
ijpds-4639	10	31	fat	fat	NOUN
ijpds-4639	10	32	which	which	PRON
ijpds-4639	10	33	has	have	VERB
ijpds-4639	10	34	the	the	DET
ijpds-4639	10	35	capability	capability	NOUN
ijpds-4639	10	36	to	to	PART
ijpds-4639	10	37	show	show	VERB
ijpds-4639	10	38	negative	negative	ADJ
ijpds-4639	10	39	impact	impact	NOUN
ijpds-4639	10	40	of	of	ADP
ijpds-4639	10	41	health	health	NOUN
ijpds-4639	10	42	,	,	PUNCT
ijpds-4639	10	43	in	in	ADP
ijpds-4639	10	44	general	general	ADJ
ijpds-4639	10	45	a	a	DET
ijpds-4639	10	46	person	person	NOUN
ijpds-4639	10	47	could	could	AUX
ijpds-4639	10	48	be	be	AUX
ijpds-4639	10	49	said	say	VERB
ijpds-4639	10	50	that	that	SCONJ
ijpds-4639	10	51	he	he	PRON
ijpds-4639	10	52	or	or	CCONJ
ijpds-4639	10	53	she	she	PRON
ijpds-4639	10	54	is	be	AUX
ijpds-4639	10	55	suffering	suffer	VERB
ijpds-4639	10	56	from	from	ADP
ijpds-4639	10	57	obesity	obesity	NOUN
ijpds-4639	10	58	by	by	ADP
ijpds-4639	10	59	checking	check	VERB
ijpds-4639	10	60	the	the	DET
ijpds-4639	10	61	bmi	bmi	NOUN
ijpds-4639	10	62	over	over	ADP
ijpds-4639	10	63	30	30	NUM
ijpds-4639	10	64	kg	kg	NOUN
ijpds-4639	10	65	/	/	SYM
ijpds-4639	10	66	m3[1	m3[1	PROPN
ijpds-4639	10	67	]	]	PUNCT
ijpds-4639	10	68	.	.	PUNCT
ijpds-4639	11	1	there	there	PRON
ijpds-4639	11	2	are	be	VERB
ijpds-4639	11	3	certain	certain	ADJ
ijpds-4639	11	4	east	east	ADJ
ijpds-4639	11	5	asian	asian	ADJ
ijpds-4639	11	6	countries	country	NOUN
ijpds-4639	11	7	they	they	PRON
ijpds-4639	11	8	apply	apply	VERB
ijpds-4639	11	9	lower	low	ADJ
ijpds-4639	11	10	value	value	NOUN
ijpds-4639	11	11	for	for	ADP
ijpds-4639	11	12	defining	define	VERB
ijpds-4639	11	13	the	the	DET
ijpds-4639	11	14	obese	obese	ADJ
ijpds-4639	11	15	condition	condition	NOUN
ijpds-4639	11	16	.	.	PUNCT
ijpds-4639	12	1	obesity	obesity	NOUN
ijpds-4639	12	2	can	can	AUX
ijpds-4639	12	3	be	be	AUX
ijpds-4639	12	4	linked	link	VERB
ijpds-4639	12	5	with	with	ADP
ijpds-4639	12	6	various	various	ADJ
ijpds-4639	12	7	other	other	ADJ
ijpds-4639	12	8	health	health	NOUN
ijpds-4639	12	9	risk	risk	NOUN
ijpds-4639	12	10	factors	factor	NOUN
ijpds-4639	12	11	,	,	PUNCT
ijpds-4639	12	12	such	such	ADJ
ijpds-4639	12	13	as	as	ADP
ijpds-4639	12	14	cardiovascular	cardiovascular	ADJ
ijpds-4639	12	15	diseases	disease	NOUN
ijpds-4639	12	16	,	,	PUNCT
ijpds-4639	12	17	type	type	NOUN
ijpds-4639	12	18	ii	ii	NOUN
ijpds-4639	12	19	diabetes	diabetes	NOUN
ijpds-4639	12	20	,	,	PUNCT
ijpds-4639	12	21	obstructive	obstructive	ADJ
ijpds-4639	12	22	sleep	sleep	NOUN
ijpds-4639	12	23	apnea	apnea	NOUN
ijpds-4639	12	24	,	,	PUNCT
ijpds-4639	12	25	certain	certain	ADJ
ijpds-4639	12	26	cancers	cancer	NOUN
ijpds-4639	12	27	,	,	PUNCT
ijpds-4639	12	28	osteoarthritis	osteoarthritis	NOUN
ijpds-4639	12	29	,	,	PUNCT
ijpds-4639	12	30	obesity	obesity	NOUN
ijpds-4639	12	31	can	can	AUX
ijpds-4639	12	32	also	also	ADV
ijpds-4639	12	33	be	be	AUX
ijpds-4639	12	34	influenced	influence	VERB
ijpds-4639	12	35	by	by	ADP
ijpds-4639	12	36	a	a	DET
ijpds-4639	12	37	reciprocal	reciprocal	ADJ
ijpds-4639	12	38	relationship	relationship	NOUN
ijpds-4639	12	39	by	by	ADP
ijpds-4639	12	40	depression	depression	NOUN
ijpds-4639	12	41	.	.	PUNCT
ijpds-4639	13	1	obese	obese	ADJ
ijpds-4639	13	2	condition	condition	NOUN
ijpds-4639	13	3	for	for	ADP
ijpds-4639	13	4	children	child	NOUN
ijpds-4639	13	5	ranging	range	VERB
ijpds-4639	13	6	between	between	ADP
ijpds-4639	13	7	the	the	DET
ijpds-4639	13	8	age	age	NOUN
ijpds-4639	13	9	of	of	ADP
ijpds-4639	13	10	519	519	NUM
ijpds-4639	13	11	,	,	PUNCT
ijpds-4639	13	12	can	can	AUX
ijpds-4639	13	13	be	be	AUX
ijpds-4639	13	14	defined	define	VERB
ijpds-4639	13	15	with	with	ADP
ijpds-4639	13	16	the	the	DET
ijpds-4639	13	17	bmi	bmi	NOUN
ijpds-4639	13	18	with	with	ADP
ijpds-4639	13	19	two	two	NUM
ijpds-4639	13	20	standard	standard	ADJ
ijpds-4639	13	21	deviations	deviation	NOUN
ijpds-4639	13	22	above	above	ADP
ijpds-4639	13	23	the	the	DET
ijpds-4639	13	24	median	median	NOUN
ijpds-4639	13	25	their	their	PRON
ijpds-4639	13	26	age	age	NOUN
ijpds-4639	13	27	group	group	NOUN
ijpds-4639	14	1	[	[	X
ijpds-4639	14	2	2	2	NUM
ijpds-4639	14	3	]	]	PUNCT
ijpds-4639	14	4	,	,	PUNCT
ijpds-4639	14	5	and	and	CCONJ
ijpds-4639	14	6	for	for	ADP
ijpds-4639	14	7	the	the	DET
ijpds-4639	14	8	age	age	NOUN
ijpds-4639	14	9	group	group	NOUN
ijpds-4639	14	10	below	below	ADP
ijpds-4639	14	11	the	the	DET
ijpds-4639	14	12	age	age	NOUN
ijpds-4639	14	13	of	of	ADP
ijpds-4639	14	14	5	5	NUM
ijpds-4639	14	15	,	,	PUNCT
ijpds-4639	14	16	the	the	DET
ijpds-4639	14	17	obese	obese	ADJ
ijpds-4639	14	18	condition	condition	NOUN
ijpds-4639	14	19	is	be	AUX
ijpds-4639	14	20	considered	consider	VERB
ijpds-4639	14	21	to	to	PART
ijpds-4639	14	22	be	be	AUX
ijpds-4639	14	23	the	the	DET
ijpds-4639	14	24	three	three	NUM
ijpds-4639	14	25	-	-	PUNCT
ijpds-4639	14	26	standard	standard	ADJ
ijpds-4639	14	27	deviation	deviation	NOUN
ijpds-4639	14	28	above	above	ADP
ijpds-4639	14	29	the	the	DET
ijpds-4639	14	30	median	median	NOUN
ijpds-4639	14	31	.	.	PUNCT
ijpds-4639	15	1	the	the	DET
ijpds-4639	15	2	assessment	assessment	NOUN
ijpds-4639	15	3	of	of	ADP
ijpds-4639	15	4	fat	fat	ADJ
ijpds-4639	15	5	distribution	distribution	NOUN
ijpds-4639	15	6	and	and	CCONJ
ijpds-4639	15	7	cardiovascular	cardiovascular	ADJ
ijpds-4639	15	8	risk	risk	NOUN
ijpds-4639	15	9	factorcould	factorcould	AUX
ijpds-4639	15	10	be	be	AUX
ijpds-4639	15	11	done	do	VERB
ijpds-4639	15	12	by	by	ADP
ijpds-4639	15	13	subdividing	subdivide	VERB
ijpds-4639	15	14	bmi	bmi	NOUN
ijpds-4639	15	15	by	by	ADP
ijpds-4639	15	16	the	the	DET
ijpds-4639	15	17	cdc	cdc	PROPN
ijpds-4639	16	1	[	[	X
ijpds-4639	16	2	3	3	NUM
ijpds-4639	16	3	]	]	PUNCT
ijpds-4639	16	4	.	.	PUNCT
ijpds-4639	17	1	when	when	SCONJ
ijpds-4639	17	2	it	it	PRON
ijpds-4639	17	3	comes	come	VERB
ijpds-4639	17	4	to	to	ADP
ijpds-4639	17	5	the	the	DET
ijpds-4639	17	6	etiological	etiological	ADJ
ijpds-4639	17	7	factors	factor	NOUN
ijpds-4639	17	8	of	of	ADP
ijpds-4639	17	9	obesity	obesity	NOUN
ijpds-4639	17	10	,	,	PUNCT
ijpds-4639	17	11	excessive	excessive	ADJ
ijpds-4639	17	12	calorie	calorie	NOUN
ijpds-4639	17	13	intake	intake	NOUN
ijpds-4639	17	14	and	and	CCONJ
ijpds-4639	17	15	access	access	NOUN
ijpds-4639	17	16	this	this	DET
ijpds-4639	17	17	article	article	NOUN
ijpds-4639	17	18	online	online	ADV
ijpds-4639	17	19	received	receive	VERB
ijpds-4639	17	20	–	–	PUNCT
ijpds-4639	17	21	24th	24th	NOUN
ijpds-4639	17	22	may	may	AUX
ijpds-4639	17	23	2024	2024	NUM
ijpds-4639	17	24	initial	initial	ADJ
ijpds-4639	17	25	review	review	NOUN
ijpds-4639	17	26	–	–	PUNCT
ijpds-4639	17	27	30th	30th	ADJ
ijpds-4639	17	28	september	september	PROPN
ijpds-4639	17	29	2024	2024	NUM
ijpds-4639	17	30	accepted	accept	VERB
ijpds-4639	17	31	–	–	PUNCT
ijpds-4639	17	32	28th	28th	ADJ
ijpds-4639	17	33	october	october	NOUN
ijpds-4639	17	34	2024	2024	NUM
ijpds-4639	17	35	quick	quick	ADJ
ijpds-4639	17	36	response	response	NOUN
ijpds-4639	17	37	code	code	NOUN
ijpds-4639	17	38	leading	lead	VERB
ijpds-4639	17	39	a	a	DET
ijpds-4639	17	40	sedentary	sedentary	ADJ
ijpds-4639	17	41	life	life	NOUN
ijpds-4639	17	42	plays	play	VERB
ijpds-4639	17	43	major	major	ADJ
ijpds-4639	17	44	role	role	NOUN
ijpds-4639	17	45	,	,	PUNCT
ijpds-4639	17	46	while	while	SCONJ
ijpds-4639	17	47	the	the	DET
ijpds-4639	17	48	genetics	genetic	NOUN
ijpds-4639	17	49	also	also	ADV
ijpds-4639	17	50	have	have	VERB
ijpds-4639	17	51	some	some	DET
ijpds-4639	17	52	role	role	NOUN
ijpds-4639	17	53	when	when	SCONJ
ijpds-4639	17	54	it	it	PRON
ijpds-4639	17	55	comes	come	VERB
ijpds-4639	17	56	to	to	ADP
ijpds-4639	17	57	obesity	obesity	NOUN
ijpds-4639	17	58	with	with	ADP
ijpds-4639	17	59	certain	certain	ADJ
ijpds-4639	17	60	genes	gene	NOUN
ijpds-4639	17	61	showing	show	VERB
ijpds-4639	17	62	influence	influence	NOUN
ijpds-4639	17	63	towards	towards	ADP
ijpds-4639	17	64	susceptibility	susceptibility	NOUN
ijpds-4639	17	65	to	to	ADP
ijpds-4639	17	66	obesity	obesity	NOUN
ijpds-4639	18	1	[	[	X
ijpds-4639	18	2	6][9	6][9	NOUN
ijpds-4639	18	3	]	]	PUNCT
ijpds-4639	18	4	.	.	PUNCT
ijpds-4639	19	1	in	in	ADP
ijpds-4639	19	2	addition	addition	NOUN
ijpds-4639	19	3	,	,	PUNCT
ijpds-4639	19	4	there	there	PRON
ijpds-4639	19	5	are	be	VERB
ijpds-4639	19	6	certain	certain	ADJ
ijpds-4639	19	7	drug	drug	NOUN
ijpds-4639	19	8	metabolism	metabolism	NOUN
ijpds-4639	19	9	system	system	NOUN
ijpds-4639	19	10	which	which	PRON
ijpds-4639	19	11	also	also	ADV
ijpds-4639	19	12	contributes	contribute	VERB
ijpds-4639	19	13	to	to	ADP
ijpds-4639	19	14	the	the	DET
ijpds-4639	19	15	condition	condition	NOUN
ijpds-4639	19	16	of	of	ADP
ijpds-4639	19	17	obesity	obesity	NOUN
ijpds-4639	19	18	,	,	PUNCT
ijpds-4639	19	19	particularly	particularly	ADV
ijpds-4639	19	20	fat	fat	ADJ
ijpds-4639	19	21	-	-	PUNCT
ijpds-4639	19	22	soluble	soluble	ADJ
ijpds-4639	19	23	drugs	drug	NOUN
ijpds-4639	19	24	,	,	PUNCT
ijpds-4639	19	25	like	like	ADP
ijpds-4639	19	26	anti	anti	ADJ
ijpds-4639	19	27	-	-	ADJ
ijpds-4639	19	28	tuberculosis	tuberculosis	ADJ
ijpds-4639	19	29	medications	medication	NOUN
ijpds-4639	19	30	[	[	X
ijpds-4639	19	31	10	10	NUM
ijpds-4639	19	32	]	]	PUNCT
ijpds-4639	19	33	.	.	PUNCT
ijpds-4639	20	1	the	the	DET
ijpds-4639	20	2	increase	increase	NOUN
ijpds-4639	20	3	risk	risk	NOUN
ijpds-4639	20	4	of	of	ADP
ijpds-4639	20	5	obesity	obesity	NOUN
ijpds-4639	20	6	is	be	AUX
ijpds-4639	20	7	also	also	ADV
ijpds-4639	20	8	accompanied	accompany	VERB
ijpds-4639	20	9	with	with	ADP
ijpds-4639	20	10	the	the	DET
ijpds-4639	20	11	treatment	treatment	NOUN
ijpds-4639	20	12	for	for	ADP
ijpds-4639	20	13	certain	certain	ADJ
ijpds-4639	20	14	physical	physical	ADJ
ijpds-4639	20	15	and	and	CCONJ
ijpds-4639	20	16	mental	mental	ADJ
ijpds-4639	20	17	illness	illness	NOUN
ijpds-4639	20	18	like	like	ADP
ijpds-4639	20	19	psychiatric	psychiatric	ADJ
ijpds-4639	20	20	disorder	disorder	NOUN
ijpds-4639	20	21	[	[	X
ijpds-4639	20	22	11	11	NUM
ijpds-4639	20	23	]	]	PUNCT
ijpds-4639	20	24	.	.	PUNCT
ijpds-4639	21	1	finally	finally	ADV
ijpds-4639	21	2	,	,	PUNCT
ijpds-4639	21	3	the	the	DET
ijpds-4639	21	4	contribution	contribution	NOUN
ijpds-4639	21	5	of	of	ADP
ijpds-4639	21	6	the	the	DET
ijpds-4639	21	7	hormone	hormone	NOUN
ijpds-4639	21	8	leptins	leptin	NOUN
ijpds-4639	21	9	plays	play	VERB
ijpds-4639	21	10	the	the	DET
ijpds-4639	21	11	vital	vital	ADJ
ijpds-4639	21	12	role	role	NOUN
ijpds-4639	21	13	in	in	ADP
ijpds-4639	21	14	obesity	obesity	NOUN
ijpds-4639	21	15	.	.	PUNCT
ijpds-4639	22	1	leptin	leptin	NOUN
ijpds-4639	22	2	is	be	AUX
ijpds-4639	22	3	a	a	DET
ijpds-4639	22	4	hormone	hormone	NOUN
ijpds-4639	22	5	with	with	ADP
ijpds-4639	22	6	helps	help	NOUN
ijpds-4639	22	7	in	in	ADP
ijpds-4639	22	8	regulating	regulate	VERB
ijpds-4639	22	9	the	the	DET
ijpds-4639	22	10	intake	intake	NOUN
ijpds-4639	22	11	of	of	ADP
ijpds-4639	22	12	food	food	NOUN
ijpds-4639	22	13	and	and	CCONJ
ijpds-4639	22	14	energy	energy	NOUN
ijpds-4639	22	15	usage	usage	NOUN
ijpds-4639	22	16	.	.	PUNCT
ijpds-4639	23	1	obsess	obsess	NOUN
ijpds-4639	23	2	condition	condition	NOUN
ijpds-4639	23	3	may	may	AUX
ijpds-4639	23	4	occur	occur	VERB
ijpds-4639	23	5	when	when	SCONJ
ijpds-4639	23	6	the	the	DET
ijpds-4639	23	7	hormone	hormone	NOUN
ijpds-4639	23	8	leptin	leptin	NOUN
ijpds-4639	23	9	have	have	AUX
ijpds-4639	23	10	lost	lose	VERB
ijpds-4639	23	11	its	its	PRON
ijpds-4639	23	12	ability	ability	NOUN
ijpds-4639	23	13	to	to	PART
ijpds-4639	23	14	signal	signal	VERB
ijpds-4639	23	15	the	the	DET
ijpds-4639	23	16	brain	brain	NOUN
ijpds-4639	23	17	about	about	ADP
ijpds-4639	23	18	proper	proper	ADJ
ijpds-4639	23	19	functioning	functioning	NOUN
ijpds-4639	23	20	of	of	ADP
ijpds-4639	23	21	food	food	NOUN
ijpds-4639	23	22	intake	intake	NOUN
ijpds-4639	23	23	and	and	CCONJ
ijpds-4639	23	24	usage	usage	NOUN
ijpds-4639	23	25	of	of	ADP
ijpds-4639	23	26	energy	energy	NOUN
ijpds-4639	23	27	.	.	PUNCT
ijpds-4639	24	1	leptin	leptin	NOUN
ijpds-4639	24	2	and	and	CCONJ
ijpds-4639	24	3	its	its	PRON
ijpds-4639	24	4	receptors	receptor	NOUN
ijpds-4639	24	5	:	:	PUNCT
ijpds-4639	24	6	leptin	leptin	NOUN
ijpds-4639	24	7	is	be	AUX
ijpds-4639	24	8	a	a	DET
ijpds-4639	24	9	neurohormone	neurohormone	NOUN
ijpds-4639	24	10	that	that	PRON
ijpds-4639	24	11	acts	act	VERB
ijpds-4639	24	12	in	in	ADP
ijpds-4639	24	13	the	the	DET
ijpds-4639	24	14	hypothalamus	hypothalamus	NOUN
ijpds-4639	24	15	to	to	PART
ijpds-4639	24	16	regulate	regulate	VERB
ijpds-4639	24	17	energy	energy	NOUN
ijpds-4639	24	18	balance	balance	NOUN
ijpds-4639	24	19	and	and	CCONJ
ijpds-4639	24	20	food	food	NOUN
ijpds-4639	24	21	intake	intake	NOUN
ijpds-4639	25	1	[	[	X
ijpds-4639	25	2	12	12	NUM
ijpds-4639	25	3	]	]	PUNCT
ijpds-4639	25	4	.	.	PUNCT
ijpds-4639	26	1	recessive	recessive	ADJ
ijpds-4639	26	2	mutations	mutation	NOUN
ijpds-4639	26	3	in	in	ADP
ijpds-4639	26	4	the	the	DET
ijpds-4639	26	5	leptin	leptin	NOUN
ijpds-4639	26	6	(	(	PUNCT
ijpds-4639	26	7	obese	obese	ADJ
ijpds-4639	26	8	,	,	PUNCT
ijpds-4639	26	9	ob	ob	NOUN
ijpds-4639	26	10	)	)	PUNCT
ijpds-4639	26	11	or	or	CCONJ
ijpds-4639	26	12	its	its	PRON
ijpds-4639	26	13	receptor	receptor	NOUN
ijpds-4639	26	14	obr	obr	NOUN
ijpds-4639	26	15	gene	gene	NOUN
ijpds-4639	26	16	result	result	NOUN
ijpds-4639	26	17	in	in	ADP
ijpds-4639	26	18	profound	profound	ADJ
ijpds-4639	26	19	obesity	obesity	NOUN
ijpds-4639	26	20	and	and	CCONJ
ijpds-4639	26	21	type	type	NOUN
ijpds-4639	26	22	ii	ii	PROPN
ijpds-4639	26	23	diabetes	diabetes	NOUN
ijpds-4639	26	24	mellitus	mellitus	NOUN
ijpds-4639	26	25	.	.	PUNCT
ijpds-4639	27	1	further	further	ADJ
ijpds-4639	27	2	studies	study	NOUN
ijpds-4639	27	3	demonstrated	demonstrate	VERB
ijpds-4639	27	4	that	that	SCONJ
ijpds-4639	27	5	in	in	ADP
ijpds-4639	27	6	_	_	PROPN
ijpds-4639	27	7	_	_	PUNCT
ijpds-4639	27	8	_	_	PUNCT
ijpds-4639	28	1	_	_	PUNCT
ijpds-4639	29	1	_	_	PUNCT
ijpds-4639	30	1	_	_	PUNCT
ijpds-4639	31	1	_	_	PUNCT
ijpds-4639	32	1	_	_	PUNCT
ijpds-4639	33	1	_	_	PUNCT
ijpds-4639	34	1	_	_	PUNCT
ijpds-4639	35	1	_	_	PUNCT
ijpds-4639	36	1	_	_	PUNCT
ijpds-4639	37	1	_	_	PUNCT
ijpds-4639	38	1	_	_	PUNCT
ijpds-4639	39	1	_	_	PUNCT
ijpds-4639	40	1	_	_	PUNCT
ijpds-4639	41	1	_	_	PUNCT
ijpds-4639	42	1	_	_	PUNCT
ijpds-4639	43	1	_	_	PUNCT
ijpds-4639	44	1	_	_	PUNCT
ijpds-4639	45	1	_	_	PUNCT
ijpds-4639	46	1	_	_	PUNCT
ijpds-4639	47	1	_	_	PUNCT
ijpds-4639	48	1	_	_	PUNCT
ijpds-4639	49	1	_	_	PUNCT
ijpds-4639	50	1	_	_	PUNCT
ijpds-4639	51	1	_	_	PUNCT
ijpds-4639	52	1	_	_	PUNCT
ijpds-4639	53	1	_	_	PUNCT
ijpds-4639	54	1	_	_	PUNCT
ijpds-4639	55	1	_	_	PUNCT
ijpds-4639	56	1	_	_	PUNCT
ijpds-4639	57	1	_	_	PUNCT
ijpds-4639	58	1	_	_	PUNCT
ijpds-4639	59	1	_	_	PUNCT
ijpds-4639	60	1	_	_	PUNCT
ijpds-4639	61	1	_	_	PUNCT
ijpds-4639	62	1	_	_	PUNCT
ijpds-4639	63	1	_	_	PUNCT
ijpds-4639	64	1	_	_	PUNCT
ijpds-4639	65	1	_	_	PUNCT
ijpds-4639	66	1	_	_	PUNCT
ijpds-4639	67	1	_	_	PUNCT
ijpds-4639	68	1	_	_	PUNCT
ijpds-4639	69	1	_	_	PUNCT
ijpds-4639	70	1	_	_	PUNCT
ijpds-4639	71	1	_	_	PUNCT
ijpds-4639	72	1	_	_	PUNCT
ijpds-4639	73	1	_	_	PUNCT
ijpds-4639	74	1	_	_	PUNCT
ijpds-4639	74	2	correspondence	correspondence	NOUN
ijpds-4639	74	3	to	to	ADP
ijpds-4639	74	4	:	:	PUNCT
ijpds-4639	74	5	poulomi	poulomi	PROPN
ijpds-4639	74	6	mishra	mishra	PROPN
ijpds-4639	74	7	.	.	PROPN
ijpds-4639	74	8	pandaveswar	pandaveswar	PROPN
ijpds-4639	74	9	school	school	NOUN
ijpds-4639	74	10	of	of	ADP
ijpds-4639	74	11	pharmacy	pharmacy	NOUN
ijpds-4639	74	12	,	,	PUNCT
ijpds-4639	74	13	pandaveswar	pandaveswar	NOUN
ijpds-4639	74	14	,	,	PUNCT
ijpds-4639	74	15	west	west	PROPN
ijpds-4639	74	16	bengal	bengal	PROPN
ijpds-4639	74	17	,	,	PUNCT
ijpds-4639	74	18	india	india	PROPN
ijpds-4639	74	19	.	.	PUNCT
ijpds-4639	74	20	email	email	NOUN
ijpds-4639	74	21	:	:	PUNCT
ijpds-4639	75	1	mishrapoulomibeliatore@gmail.com	mishrapoulomibeliatore@gmail.com	X
ijpds-4639	76	1	o	o	X
ijpds-4639	76	2	mailto:mishrapoulomibeliatore@gmail.com	mailto:mishrapoulomibeliatore@gmail.com	PROPN
ijpds-4639	76	3	singha	singha	PROPN
ijpds-4639	76	4	et	et	PROPN
ijpds-4639	76	5	al	al	PROPN
ijpds-4639	76	6	.	.	PROPN
ijpds-4639	76	7	leptin	leptin	PROPN
ijpds-4639	76	8	:	:	PUNCT
ijpds-4639	76	9	its	its	PRON
ijpds-4639	76	10	crucial	crucial	ADJ
ijpds-4639	76	11	role	role	NOUN
ijpds-4639	76	12	in	in	ADP
ijpds-4639	76	13	the	the	DET
ijpds-4639	76	14	fight	fight	NOUN
ijpds-4639	76	15	against	against	ADP
ijpds-4639	76	16	obesity	obesity	NOUN
ijpds-4639	76	17	online	online	ADJ
ijpds-4639	76	18	first	first	PROPN
ijpds-4639	76	19	indian	indian	PROPN
ijpds-4639	76	20	j	j	PROPN
ijpds-4639	76	21	pharm	pharm	PROPN
ijpds-4639	76	22	drug	drug	PROPN
ijpds-4639	76	23	studies	study	NOUN
ijpds-4639	76	24	|	|	ADV
ijpds-4639	76	25	2	2	NUM
ijpds-4639	76	26	addition	addition	NOUN
ijpds-4639	76	27	to	to	ADP
ijpds-4639	76	28	its	its	PRON
ijpds-4639	76	29	role	role	NOUN
ijpds-4639	76	30	as	as	ADP
ijpds-4639	76	31	a	a	DET
ijpds-4639	76	32	neurohormone	neurohormone	NOUN
ijpds-4639	76	33	,	,	PUNCT
ijpds-4639	76	34	leptin	leptin	NOUN
ijpds-4639	76	35	can	can	AUX
ijpds-4639	76	36	modulate	modulate	VERB
ijpds-4639	76	37	immune	immune	ADJ
ijpds-4639	76	38	response	response	NOUN
ijpds-4639	76	39	,	,	PUNCT
ijpds-4639	76	40	fertility	fertility	NOUN
ijpds-4639	76	41	,	,	PUNCT
ijpds-4639	76	42	and	and	CCONJ
ijpds-4639	76	43	hematopoiesis	hematopoiesis	NOUN
ijpds-4639	76	44	,	,	PUNCT
ijpds-4639	76	45	acting	act	VERB
ijpds-4639	76	46	as	as	ADP
ijpds-4639	76	47	a	a	DET
ijpds-4639	76	48	mitogen	mitogen	NOUN
ijpds-4639	76	49	,	,	PUNCT
ijpds-4639	76	50	metabolic	metabolic	NOUN
ijpds-4639	76	51	regulator	regulator	NOUN
ijpds-4639	76	52	,	,	PUNCT
ijpds-4639	76	53	or	or	CCONJ
ijpds-4639	76	54	pro	pro	ADJ
ijpds-4639	76	55	angiogenic	angiogenic	ADJ
ijpds-4639	76	56	factor	factor	NOUN
ijpds-4639	76	57	[	[	X
ijpds-4639	76	58	13	13	NUM
ijpds-4639	76	59	]	]	PUNCT
ijpds-4639	76	60	.	.	PUNCT
ijpds-4639	77	1	the	the	DET
ijpds-4639	77	2	central	central	ADJ
ijpds-4639	77	3	regulation	regulation	NOUN
ijpds-4639	77	4	of	of	ADP
ijpds-4639	77	5	food	food	NOUN
ijpds-4639	77	6	intake	intake	NOUN
ijpds-4639	77	7	and	and	CCONJ
ijpds-4639	77	8	energy	energy	NOUN
ijpds-4639	77	9	expenditure	expenditure	NOUN
ijpds-4639	77	10	is	be	AUX
ijpds-4639	77	11	mediated	mediate	VERB
ijpds-4639	77	12	through	through	ADP
ijpds-4639	77	13	the	the	DET
ijpds-4639	77	14	binding	binding	NOUN
ijpds-4639	77	15	of	of	ADP
ijpds-4639	77	16	leptin	leptin	NOUN
ijpds-4639	77	17	to	to	ADP
ijpds-4639	77	18	its	its	PRON
ijpds-4639	77	19	receptor	receptor	NOUN
ijpds-4639	77	20	obr	obr	PROPN
ijpds-4639	77	21	,	,	PUNCT
ijpds-4639	77	22	a	a	DET
ijpds-4639	77	23	type	type	NOUN
ijpds-4639	77	24	1	1	NUM
ijpds-4639	77	25	cytokine	cytokine	NOUN
ijpds-4639	77	26	receptor	receptor	NOUN
ijpds-4639	77	27	.	.	PUNCT
ijpds-4639	78	1	several	several	ADJ
ijpds-4639	78	2	isoforms	isoform	NOUN
ijpds-4639	78	3	of	of	ADP
ijpds-4639	78	4	obr	obr	PROPN
ijpds-4639	78	5	have	have	AUX
ijpds-4639	78	6	been	be	AUX
ijpds-4639	78	7	described	describe	VERB
ijpds-4639	78	8	as	as	ADP
ijpds-4639	78	9	a	a	DET
ijpds-4639	78	10	result	result	NOUN
ijpds-4639	78	11	of	of	ADP
ijpds-4639	78	12	alternative	alternative	ADJ
ijpds-4639	78	13	mrna	mrna	PROPN
ijpds-4639	78	14	splicing	splicing	NOUN
ijpds-4639	78	15	leading	lead	VERB
ijpds-4639	78	16	to	to	ADP
ijpds-4639	78	17	several	several	ADJ
ijpds-4639	78	18	short	short	ADJ
ijpds-4639	78	19	isoforms	isoform	NOUN
ijpds-4639	78	20	(	(	PUNCT
ijpds-4639	78	21	obra	obra	PROPN
ijpds-4639	78	22	,	,	PUNCT
ijpds-4639	78	23	obrc	obrc	NOUN
ijpds-4639	78	24	,	,	PUNCT
ijpds-4639	78	25	obrd	obrd	PROPN
ijpds-4639	78	26	,	,	PUNCT
ijpds-4639	78	27	and	and	CCONJ
ijpds-4639	78	28	obrf	obrf	ADV
ijpds-4639	78	29	)	)	PUNCT
ijpds-4639	78	30	,	,	PUNCT
ijpds-4639	78	31	one	one	NUM
ijpds-4639	78	32	long	long	ADJ
ijpds-4639	78	33	isoform	isoform	NOUN
ijpds-4639	78	34	obrb	obrb	VERB
ijpds-4639	78	35	with	with	ADP
ijpds-4639	78	36	a	a	DET
ijpds-4639	78	37	long	long	ADJ
ijpds-4639	78	38	cytosolic	cytosolic	ADJ
ijpds-4639	78	39	c	c	NOUN
ijpds-4639	78	40	-	-	PUNCT
ijpds-4639	78	41	terminus	terminus	NOUN
ijpds-4639	78	42	tail	tail	NOUN
ijpds-4639	78	43	and	and	CCONJ
ijpds-4639	78	44	one	one	NUM
ijpds-4639	78	45	soluble	soluble	ADJ
ijpds-4639	78	46	isoform	isoform	NOUN
ijpds-4639	78	47	obre	obre	NOUN
ijpds-4639	79	1	[	[	X
ijpds-4639	79	2	14	14	NUM
ijpds-4639	79	3	]	]	PUNCT
ijpds-4639	79	4	.	.	PUNCT
ijpds-4639	80	1	hence	hence	ADV
ijpds-4639	80	2	,	,	PUNCT
ijpds-4639	80	3	obr	obr	PROPN
ijpds-4639	80	4	isoforms	isoform	NOUN
ijpds-4639	80	5	differ	differ	VERB
ijpds-4639	80	6	in	in	ADP
ijpds-4639	80	7	the	the	DET
ijpds-4639	80	8	length	length	NOUN
ijpds-4639	80	9	of	of	ADP
ijpds-4639	80	10	their	their	PRON
ijpds-4639	80	11	intracellular	intracellular	ADJ
ijpds-4639	80	12	region	region	NOUN
ijpds-4639	80	13	but	but	CCONJ
ijpds-4639	80	14	share	share	NOUN
ijpds-4639	80	15	identical	identical	ADJ
ijpds-4639	80	16	extracellular	extracellular	ADJ
ijpds-4639	80	17	domains	domain	NOUN
ijpds-4639	80	18	.	.	PUNCT
ijpds-4639	81	1	while	while	SCONJ
ijpds-4639	81	2	short	short	ADJ
ijpds-4639	81	3	isoforms	isoform	NOUN
ijpds-4639	81	4	are	be	AUX
ijpds-4639	81	5	ubiquitously	ubiquitously	ADV
ijpds-4639	81	6	expressed	express	VERB
ijpds-4639	81	7	,	,	PUNCT
ijpds-4639	81	8	obrb	obrb	VERB
ijpds-4639	81	9	expression	expression	NOUN
ijpds-4639	81	10	is	be	AUX
ijpds-4639	81	11	more	more	ADV
ijpds-4639	81	12	restricted	restrict	VERB
ijpds-4639	81	13	with	with	ADP
ijpds-4639	81	14	high	high	ADJ
ijpds-4639	81	15	levels	level	NOUN
ijpds-4639	81	16	in	in	ADP
ijpds-4639	81	17	hypothalamic	hypothalamic	ADJ
ijpds-4639	81	18	nuclei	nucleus	NOUN
ijpds-4639	81	19	such	such	ADJ
ijpds-4639	81	20	as	as	ADP
ijpds-4639	81	21	the	the	DET
ijpds-4639	81	22	arcuate	arcuate	ADJ
ijpds-4639	81	23	nucleus	nucleus	NOUN
ijpds-4639	81	24	(	(	PUNCT
ijpds-4639	81	25	arc	arc	NOUN
ijpds-4639	81	26	)	)	PUNCT
ijpds-4639	81	27	.	.	PUNCT
ijpds-4639	82	1	the	the	DET
ijpds-4639	82	2	hypothalamic	hypothalamic	ADJ
ijpds-4639	82	3	arc	arc	NOUN
ijpds-4639	82	4	has	have	VERB
ijpds-4639	82	5	an	an	DET
ijpds-4639	82	6	important	important	ADJ
ijpds-4639	82	7	role	role	NOUN
ijpds-4639	82	8	in	in	ADP
ijpds-4639	82	9	the	the	DET
ijpds-4639	82	10	development	development	NOUN
ijpds-4639	82	11	of	of	ADP
ijpds-4639	82	12	leptin	leptin	NOUN
ijpds-4639	82	13	resistance	resistance	NOUN
ijpds-4639	82	14	.	.	PUNCT
ijpds-4639	83	1	accordingly	accordingly	ADV
ijpds-4639	83	2	,	,	PUNCT
ijpds-4639	83	3	exposure	exposure	NOUN
ijpds-4639	83	4	of	of	ADP
ijpds-4639	83	5	rodents	rodent	NOUN
ijpds-4639	83	6	to	to	ADP
ijpds-4639	83	7	a	a	DET
ijpds-4639	83	8	high	high	ADJ
ijpds-4639	83	9	-	-	PUNCT
ijpds-4639	83	10	fat	fat	NOUN
ijpds-4639	83	11	diet	diet	NOUN
ijpds-4639	83	12	rapidly	rapidly	ADV
ijpds-4639	83	13	decreases	decrease	VERB
ijpds-4639	83	14	the	the	DET
ijpds-4639	83	15	phosphorylation	phosphorylation	NOUN
ijpds-4639	83	16	of	of	ADP
ijpds-4639	83	17	stat3	stat3	NOUN
ijpds-4639	83	18	in	in	ADP
ijpds-4639	83	19	the	the	DET
ijpds-4639	83	20	arc	arc	NOUN
ijpds-4639	83	21	or	or	CCONJ
ijpds-4639	83	22	the	the	DET
ijpds-4639	83	23	ventral	ventral	ADJ
ijpds-4639	83	24	tegmental	tegmental	ADJ
ijpds-4639	83	25	area	area	NOUN
ijpds-4639	83	26	(	(	PUNCT
ijpds-4639	83	27	vta	vta	PROPN
ijpds-4639	83	28	)	)	PUNCT
ijpds-4639	83	29	,	,	PUNCT
ijpds-4639	83	30	while	while	SCONJ
ijpds-4639	83	31	leptin	leptin	NOUN
ijpds-4639	83	32	-	-	PUNCT
ijpds-4639	83	33	sensitivity	sensitivity	NOUN
ijpds-4639	83	34	is	be	AUX
ijpds-4639	83	35	simultaneously	simultaneously	ADV
ijpds-4639	83	36	maintained	maintain	VERB
ijpds-4639	83	37	in	in	ADP
ijpds-4639	83	38	some	some	DET
ijpds-4639	83	39	other	other	ADJ
ijpds-4639	83	40	hypothalamic	hypothalamic	ADJ
ijpds-4639	83	41	nuclei	nucleus	NOUN
ijpds-4639	83	42	.	.	PUNCT
ijpds-4639	84	1	while	while	SCONJ
ijpds-4639	84	2	the	the	DET
ijpds-4639	84	3	biological	biological	ADJ
ijpds-4639	84	4	function	function	NOUN
ijpds-4639	84	5	of	of	ADP
ijpds-4639	84	6	the	the	DET
ijpds-4639	84	7	short	short	ADJ
ijpds-4639	84	8	isoforms	isoform	NOUN
ijpds-4639	84	9	is	be	AUX
ijpds-4639	84	10	still	still	ADV
ijpds-4639	84	11	elusive	elusive	ADJ
ijpds-4639	84	12	,	,	PUNCT
ijpds-4639	84	13	it	it	PRON
ijpds-4639	84	14	is	be	AUX
ijpds-4639	84	15	well	well	ADV
ijpds-4639	84	16	established	establish	VERB
ijpds-4639	84	17	that	that	SCONJ
ijpds-4639	84	18	obftb	obftb	NOUN
ijpds-4639	84	19	is	be	AUX
ijpds-4639	84	20	the	the	DET
ijpds-4639	84	21	main	main	ADJ
ijpds-4639	84	22	isoform	isoform	NOUN
ijpds-4639	84	23	responsible	responsible	ADJ
ijpds-4639	84	24	for	for	ADP
ijpds-4639	84	25	the	the	DET
ijpds-4639	84	26	effect	effect	NOUN
ijpds-4639	84	27	of	of	ADP
ijpds-4639	84	28	leptin	leptin	NOUN
ijpds-4639	84	29	on	on	ADP
ijpds-4639	84	30	body	body	NOUN
ijpds-4639	84	31	weight	weight	NOUN
ijpds-4639	84	32	control	control	NOUN
ijpds-4639	84	33	.	.	PUNCT
ijpds-4639	85	1	the	the	DET
ijpds-4639	85	2	weight	weight	NOUN
ijpds-4639	85	3	lowering	lower	VERB
ijpds-4639	85	4	properties	property	NOUN
ijpds-4639	85	5	of	of	ADP
ijpds-4639	85	6	leptin	leptin	NOUN
ijpds-4639	85	7	via	via	ADP
ijpds-4639	85	8	obrh	obrh	PROPN
ijpds-4639	85	9	has	have	AUX
ijpds-4639	85	10	been	be	AUX
ijpds-4639	85	11	suggested	suggest	VERB
ijpds-4639	85	12	to	to	PART
ijpds-4639	85	13	be	be	AUX
ijpds-4639	85	14	centrally	centrally	ADV
ijpds-4639	85	15	mediated	mediate	VERB
ijpds-4639	85	16	.	.	PUNCT
ijpds-4639	86	1	once	once	ADV
ijpds-4639	86	2	activated	activate	VERB
ijpds-4639	86	3	after	after	ADP
ijpds-4639	86	4	leptin	leptin	NOUN
ijpds-4639	86	5	binding	bind	VERB
ijpds-4639	86	6	,	,	PUNCT
ijpds-4639	86	7	obrh	obrh	ADJ
ijpds-4639	86	8	is	be	AUX
ijpds-4639	86	9	able	able	ADJ
ijpds-4639	86	10	to	to	PART
ijpds-4639	86	11	trigger	trigger	VERB
ijpds-4639	86	12	various	various	ADJ
ijpds-4639	86	13	signal	signal	ADJ
ijpds-4639	86	14	transduction	transduction	NOUN
ijpds-4639	86	15	pathways	pathway	NOUN
ijpds-4639	86	16	.	.	PUNCT
ijpds-4639	87	1	activation	activation	NOUN
ijpds-4639	87	2	of	of	ADP
ijpds-4639	87	3	the	the	DET
ijpds-4639	87	4	janus	janus	PROPN
ijpds-4639	87	5	tyrosine	tyrosine	PROPN
ijpds-4639	87	6	kinase	kinase	PROPN
ijpds-4639	87	7	2	2	NUM
ijpds-4639	87	8	(	(	PUNCT
ijpds-4639	87	9	jak2)/signal	jak2)/signal	ADJ
ijpds-4639	87	10	transducer	transducer	NOUN
ijpds-4639	87	11	and	and	CCONJ
ijpds-4639	87	12	activator	activator	NOUN
ijpds-4639	87	13	of	of	ADP
ijpds-4639	87	14	transcription	transcription	NOUN
ijpds-4639	87	15	3	3	NUM
ijpds-4639	87	16	(	(	PUNCT
ijpds-4639	87	17	stat3	stat3	NOUN
ijpds-4639	87	18	)	)	PUNCT
ijpds-4639	87	19	pathway	pathway	NOUN
ijpds-4639	87	20	leads	lead	VERB
ijpds-4639	87	21	to	to	ADP
ijpds-4639	87	22	an	an	DET
ijpds-4639	87	23	increase	increase	NOUN
ijpds-4639	87	24	of	of	ADP
ijpds-4639	87	25	anorexigenic	anorexigenic	ADJ
ijpds-4639	87	26	signals	signal	NOUN
ijpds-4639	87	27	and	and	CCONJ
ijpds-4639	87	28	a	a	DET
ijpds-4639	87	29	decrease	decrease	NOUN
ijpds-4639	87	30	of	of	ADP
ijpds-4639	87	31	orexigenic	orexigenic	ADJ
ijpds-4639	87	32	signals	signal	NOUN
ijpds-4639	87	33	[	[	X
ijpds-4639	87	34	15	15	NUM
ijpds-4639	87	35	]	]	PUNCT
ijpds-4639	87	36	.	.	PUNCT
ijpds-4639	88	1	leptin	leptin	NOUN
ijpds-4639	88	2	is	be	AUX
ijpds-4639	88	3	also	also	ADV
ijpds-4639	88	4	able	able	ADJ
ijpds-4639	88	5	to	to	PART
ijpds-4639	88	6	activate	activate	VERB
ijpds-4639	88	7	the	the	DET
ijpds-4639	88	8	insulin	insulin	NOUN
ijpds-4639	88	9	receptor	receptor	NOUN
ijpds-4639	88	10	substrate	substrate	NOUN
ijpds-4639	88	11	(	(	PUNCT
ijpds-4639	88	12	irs)/phosphatidylinositide	irs)/phosphatidylinositide	NOUN
ijpds-4639	88	13	3	3	NUM
ijpds-4639	88	14	-	-	PUNCT
ijpds-4639	88	15	kinase	kinase	NOUN
ijpds-4639	88	16	(	(	PUNCT
ijpds-4639	88	17	pi3k	pi3k	NOUN
ijpds-4639	88	18	)	)	PUNCT
ijpds-4639	88	19	pathway	pathway	NOUN
ijpds-4639	88	20	,	,	PUNCT
ijpds-4639	88	21	essential	essential	ADJ
ijpds-4639	88	22	for	for	ADP
ijpds-4639	88	23	the	the	DET
ijpds-4639	88	24	regulation	regulation	NOUN
ijpds-4639	88	25	of	of	ADP
ijpds-4639	88	26	glucose	glucose	NOUN
ijpds-4639	88	27	homeostasis	homeostasis	NOUN
ijpds-4639	89	1	[	[	X
ijpds-4639	89	2	16	16	NUM
ijpds-4639	89	3	]	]	PUNCT
ijpds-4639	89	4	.	.	PUNCT
ijpds-4639	90	1	moreover	moreover	ADV
ijpds-4639	90	2	,	,	PUNCT
ijpds-4639	90	3	leptin	leptin	NOUN
ijpds-4639	90	4	inhibits	inhibit	VERB
ijpds-4639	90	5	the	the	DET
ijpds-4639	90	6	energy	energy	NOUN
ijpds-4639	90	7	10	10	NUM
ijpds-4639	90	8	sensor	sensor	NOUN
ijpds-4639	90	9	adenosine	adenosine	NOUN
ijpds-4639	90	10	monophosphate	monophosphate	NOUN
ijpds-4639	90	11	activated	activate	VERB
ijpds-4639	90	12	protein	protein	NOUN
ijpds-4639	90	13	kinase	kinase	NOUN
ijpds-4639	90	14	(	(	PUNCT
ijpds-4639	90	15	ampk	ampk	PROPN
ijpds-4639	90	16	)	)	PUNCT
ijpds-4639	90	17	in	in	ADP
ijpds-4639	90	18	the	the	DET
ijpds-4639	90	19	brain	brain	NOUN
ijpds-4639	90	20	,	,	PUNCT
ijpds-4639	90	21	to	to	PART
ijpds-4639	90	22	decrease	decrease	VERB
ijpds-4639	90	23	eating	eat	VERB
ijpds-4639	90	24	.	.	PUNCT
ijpds-4639	91	1	the	the	DET
ijpds-4639	91	2	activation	activation	NOUN
ijpds-4639	91	3	of	of	ADP
ijpds-4639	91	4	extracellular	extracellular	ADJ
ijpds-4639	91	5	signal	signal	NOUN
ijpds-4639	91	6	regulated	regulate	VERB
ijpds-4639	91	7	kinase	kinase	PROPN
ijpds-4639	91	8	(	(	PUNCT
ijpds-4639	91	9	erk	erk	PROPN
ijpds-4639	91	10	)	)	PUNCT
ijpds-4639	91	11	is	be	AUX
ijpds-4639	91	12	another	another	DET
ijpds-4639	91	13	pathway	pathway	NOUN
ijpds-4639	91	14	mediating	mediate	VERB
ijpds-4639	91	15	the	the	DET
ijpds-4639	91	16	anorectic	anorectic	ADJ
ijpds-4639	91	17	action	action	NOUN
ijpds-4639	91	18	of	of	ADP
ijpds-4639	91	19	leptin	leptin	NOUN
ijpds-4639	91	20	in	in	ADP
ijpds-4639	91	21	the	the	DET
ijpds-4639	91	22	hypothalamus	hypothalamus	PROPN
ijpds-4639	91	23	.	.	PUNCT
ijpds-4639	92	1	leptin	leptin	NOUN
ijpds-4639	92	2	expression	expression	NOUN
ijpds-4639	92	3	in	in	ADP
ijpds-4639	92	4	obesity	obesity	NOUN
ijpds-4639	92	5	:	:	PUNCT
ijpds-4639	92	6	early	early	ADJ
ijpds-4639	92	7	onset	onset	NOUN
ijpds-4639	92	8	obesities	obesity	NOUN
ijpds-4639	92	9	has	have	VERB
ijpds-4639	92	10	the	the	DET
ijpds-4639	92	11	capability	capability	NOUN
ijpds-4639	92	12	to	to	PART
ijpds-4639	92	13	form	form	VERB
ijpds-4639	92	14	rare	rare	ADJ
ijpds-4639	92	15	genetic	genetic	ADJ
ijpds-4639	92	16	mutations	mutation	NOUN
ijpds-4639	92	17	which	which	PRON
ijpds-4639	92	18	can	can	AUX
ijpds-4639	92	19	hamper	hamper	VERB
ijpds-4639	92	20	leptin	leptin	NOUN
ijpds-4639	92	21	signaling	signaling	NOUN
ijpds-4639	92	22	which	which	PRON
ijpds-4639	92	23	might	might	AUX
ijpds-4639	92	24	lead	lead	VERB
ijpds-4639	92	25	to	to	ADP
ijpds-4639	92	26	congenital	congenital	ADJ
ijpds-4639	92	27	leptin	leptin	NOUN
ijpds-4639	92	28	deficiency	deficiency	NOUN
ijpds-4639	92	29	or	or	CCONJ
ijpds-4639	92	30	leptin	leptin	NOUN
ijpds-4639	92	31	resistance	resistance	NOUN
ijpds-4639	92	32	.	.	PUNCT
ijpds-4639	93	1	hyperleptinemia	hyperleptinemia	NOUN
ijpds-4639	93	2	and	and	CCONJ
ijpds-4639	93	3	resistance	resistance	NOUN
ijpds-4639	93	4	to	to	ADP
ijpds-4639	93	5	reducing	reduce	VERB
ijpds-4639	93	6	body	body	NOUN
ijpds-4639	93	7	mass	mass	NOUN
ijpds-4639	93	8	is	be	AUX
ijpds-4639	93	9	the	the	DET
ijpds-4639	93	10	general	general	ADJ
ijpds-4639	93	11	characteristics	characteristic	NOUN
ijpds-4639	93	12	of	of	ADP
ijpds-4639	93	13	leptin	leptin	NOUN
ijpds-4639	93	14	resistance	resistance	NOUN
ijpds-4639	94	1	[	[	X
ijpds-4639	94	2	5][6][17][18	5][6][17][18	NUM
ijpds-4639	94	3	]	]	PUNCT
ijpds-4639	94	4	.	.	PUNCT
ijpds-4639	95	1	a	a	DET
ijpds-4639	95	2	person	person	NOUN
ijpds-4639	95	3	is	be	AUX
ijpds-4639	95	4	leptin	leptin	NOUN
ijpds-4639	95	5	resistant	resistant	ADJ
ijpds-4639	95	6	,	,	PUNCT
ijpds-4639	95	7	can	can	AUX
ijpds-4639	95	8	only	only	ADV
ijpds-4639	95	9	be	be	AUX
ijpds-4639	95	10	said	say	VERB
ijpds-4639	95	11	with	with	ADP
ijpds-4639	95	12	the	the	DET
ijpds-4639	95	13	presence	presence	NOUN
ijpds-4639	95	14	of	of	ADP
ijpds-4639	95	15	leptin	leptin	NOUN
ijpds-4639	95	16	in	in	ADP
ijpds-4639	95	17	plasma	plasma	NOUN
ijpds-4639	95	18	at	at	ADP
ijpds-4639	95	19	higher	high	ADJ
ijpds-4639	95	20	amount	amount	NOUN
ijpds-4639	95	21	,	,	PUNCT
ijpds-4639	95	22	high	high	ADJ
ijpds-4639	95	23	amount	amount	NOUN
ijpds-4639	95	24	of	of	ADP
ijpds-4639	95	25	leptin	leptin	NOUN
ijpds-4639	95	26	in	in	ADP
ijpds-4639	95	27	blood	blood	NOUN
ijpds-4639	95	28	plasma	plasma	NOUN
ijpds-4639	95	29	certainly	certainly	ADV
ijpds-4639	95	30	corelates	corelate	VERB
ijpds-4639	95	31	with	with	ADP
ijpds-4639	95	32	body	body	NOUN
ijpds-4639	95	33	fat	fat	ADJ
ijpds-4639	95	34	percentage	percentage	NOUN
ijpds-4639	95	35	.	.	PUNCT
ijpds-4639	96	1	several	several	ADJ
ijpds-4639	96	2	weight	weight	NOUN
ijpds-4639	96	3	loss	loss	NOUN
ijpds-4639	96	4	studies	study	NOUN
ijpds-4639	96	5	have	have	AUX
ijpds-4639	96	6	revealed	reveal	VERB
ijpds-4639	96	7	that	that	SCONJ
ijpds-4639	96	8	the	the	DET
ijpds-4639	96	9	level	level	NOUN
ijpds-4639	96	10	of	of	ADP
ijpds-4639	96	11	leptin	leptin	NOUN
ijpds-4639	96	12	can	can	AUX
ijpds-4639	96	13	decrease	decrease	VERB
ijpds-4639	96	14	initially	initially	ADV
ijpds-4639	96	15	and	and	CCONJ
ijpds-4639	96	16	then	then	ADV
ijpds-4639	96	17	gradually	gradually	ADV
ijpds-4639	96	18	rise	rise	VERB
ijpds-4639	96	19	with	with	ADP
ijpds-4639	96	20	continued	continue	VERB
ijpds-4639	96	21	weight	weight	NOUN
ijpds-4639	96	22	loss	loss	NOUN
ijpds-4639	96	23	.	.	PUNCT
ijpds-4639	97	1	matheny	matheny	PROPN
ijpds-4639	97	2	et	et	PROPN
ijpds-4639	97	3	al	al	PROPN
ijpds-4639	97	4	.	.	PROPN
ijpds-4639	97	5	’s	’s	PART
ijpds-4639	97	6	research	research	NOUN
ijpds-4639	97	7	put	put	VERB
ijpds-4639	97	8	light	light	NOUN
ijpds-4639	97	9	on	on	ADP
ijpds-4639	97	10	leptin	leptin	NOUN
ijpds-4639	97	11	resistance	resistance	NOUN
ijpds-4639	97	12	can	can	AUX
ijpds-4639	97	13	be	be	AUX
ijpds-4639	97	14	induced	induce	VERB
ijpds-4639	97	15	in	in	ADP
ijpds-4639	97	16	the	the	DET
ijpds-4639	97	17	arcuate	arcuate	ADJ
ijpds-4639	97	18	nucleus	nucleus	NOUN
ijpds-4639	97	19	(	(	PUNCT
ijpds-4639	97	20	arc	arc	NOUN
ijpds-4639	97	21	)	)	PUNCT
ijpds-4639	97	22	and	and	CCONJ
ijpds-4639	97	23	ventral	ventral	ADJ
ijpds-4639	97	24	tegmental	tegmental	NOUN
ijpds-4639	97	25	are	be	AUX
ijpds-4639	97	26	(	(	PUNCT
ijpds-4639	97	27	vta	vta	PROPN
ijpds-4639	97	28	)	)	PUNCT
ijpds-4639	97	29	of	of	ADP
ijpds-4639	97	30	the	the	DET
ijpds-4639	97	31	brain	brain	NOUN
ijpds-4639	97	32	with	with	ADP
ijpds-4639	97	33	high	high	ADJ
ijpds-4639	97	34	fat	fat	ADJ
ijpds-4639	97	35	diets	diet	NOUN
ijpds-4639	97	36	,	,	PUNCT
ijpds-4639	97	37	while	while	SCONJ
ijpds-4639	97	38	when	when	SCONJ
ijpds-4639	97	39	it	it	PRON
ijpds-4639	97	40	comes	come	VERB
ijpds-4639	97	41	to	to	ADP
ijpds-4639	97	42	medial	medial	ADJ
ijpds-4639	97	43	basal	basal	ADJ
ijpds-4639	97	44	hypothalamic	hypothalamic	ADJ
ijpds-4639	97	45	region	region	NOUN
ijpds-4639	97	46	it	it	PRON
ijpds-4639	97	47	retains	retain	VERB
ijpds-4639	97	48	sensitivity	sensitivity	NOUN
ijpds-4639	97	49	[	[	X
ijpds-4639	97	50	20][21	20][21	PROPN
ijpds-4639	97	51	]	]	X
ijpds-4639	97	52	.	.	PUNCT
ijpds-4639	98	1	the	the	DET
ijpds-4639	98	2	critical	critical	ADJ
ijpds-4639	98	3	role	role	NOUN
ijpds-4639	98	4	of	of	ADP
ijpds-4639	98	5	arc	arc	NOUN
ijpds-4639	98	6	in	in	ADP
ijpds-4639	98	7	leptin	leptin	NOUN
ijpds-4639	98	8	can	can	AUX
ijpds-4639	98	9	be	be	AUX
ijpds-4639	98	10	indicated	indicate	VERB
ijpds-4639	98	11	by	by	ADP
ijpds-4639	98	12	targeting	target	VERB
ijpds-4639	98	13	downregulation	downregulation	NOUN
ijpds-4639	98	14	of	of	ADP
ijpds-4639	98	15	leptin	leptin	NOUN
ijpds-4639	98	16	receptor	receptor	NOUN
ijpds-4639	98	17	expression	expression	NOUN
ijpds-4639	98	18	in	in	ADP
ijpds-4639	98	19	the	the	DET
ijpds-4639	98	20	arc	arc	NOUN
ijpds-4639	98	21	promoting	promote	VERB
ijpds-4639	98	22	diet	diet	NOUN
ijpds-4639	98	23	-	-	PUNCT
ijpds-4639	98	24	induced	induce	VERB
ijpds-4639	98	25	obesity	obesity	NOUN
ijpds-4639	98	26	.	.	PUNCT
ijpds-4639	99	1	activation	activation	NOUN
ijpds-4639	99	2	of	of	ADP
ijpds-4639	99	3	socs3	socs3	ADJ
ijpds-4639	99	4	and	and	CCONJ
ijpds-4639	99	5	stat3	stat3	NOUN
ijpds-4639	99	6	resistance	resistance	NOUN
ijpds-4639	99	7	to	to	PART
ijpds-4639	99	8	leptin	leptin	VERB
ijpds-4639	99	9	in	in	ADP
ijpds-4639	99	10	neuron	neuron	NOUN
ijpds-4639	99	11	such	such	ADJ
ijpds-4639	99	12	as	as	ADP
ijpds-4639	99	13	pro	pro	ADJ
ijpds-4639	99	14	-	-	ADJ
ijpds-4639	99	15	opiomelanocortin	opiomelanocortin	ADJ
ijpds-4639	99	16	(	(	PUNCT
ijpds-4639	99	17	pomc	pomc	NOUN
ijpds-4639	99	18	)	)	PUNCT
ijpds-4639	99	19	and	and	CCONJ
ijpds-4639	99	20	agrp	agrp	NOUN
ijpds-4639	99	21	in	in	ADP
ijpds-4639	99	22	rodents	rodent	NOUN
ijpds-4639	99	23	with	with	ADP
ijpds-4639	99	24	high	high	ADJ
ijpds-4639	99	25	-	-	PUNCT
ijpds-4639	99	26	fat	fat	NOUN
ijpds-4639	99	27	content	content	NOUN
ijpds-4639	99	28	diet	diet	PROPN
ijpds-4639	99	29	.	.	PUNCT
ijpds-4639	100	1	while	while	SCONJ
ijpds-4639	100	2	agrp	agrp	NOUN
ijpds-4639	100	3	neurons	neuron	NOUN
ijpds-4639	100	4	shows	show	VERB
ijpds-4639	100	5	increased	increase	VERB
ijpds-4639	100	6	sensitivity	sensitivity	NOUN
ijpds-4639	100	7	towards	towards	ADP
ijpds-4639	100	8	leptin	leptin	NOUN
ijpds-4639	100	9	when	when	SCONJ
ijpds-4639	100	10	the	the	DET
ijpds-4639	100	11	rodents	rodent	NOUN
ijpds-4639	100	12	are	be	AUX
ijpds-4639	100	13	shifted	shift	VERB
ijpds-4639	100	14	to	to	ADP
ijpds-4639	100	15	low	low	ADJ
ijpds-4639	100	16	-	-	PUNCT
ijpds-4639	100	17	fat	fat	NOUN
ijpds-4639	100	18	content	content	NOUN
ijpds-4639	100	19	diet	diet	NOUN
ijpds-4639	100	20	.	.	PUNCT
ijpds-4639	101	1	polymorphism	polymorphism	NOUN
ijpds-4639	101	2	in	in	ADP
ijpds-4639	101	3	the	the	DET
ijpds-4639	101	4	crystalline	crystalline	ADJ
ijpds-4639	101	5	structure	structure	NOUN
ijpds-4639	101	6	of	of	ADP
ijpds-4639	101	7	the	the	DET
ijpds-4639	101	8	leptin	leptin	NOUN
ijpds-4639	101	9	(	(	PUNCT
ijpds-4639	101	10	ob	ob	NOUN
ijpds-4639	101	11	)	)	PUNCT
ijpds-4639	101	12	and	and	CCONJ
ijpds-4639	101	13	leptin	leptin	NOUN
ijpds-4639	101	14	receptor	receptor	NOUN
ijpds-4639	101	15	(	(	PUNCT
ijpds-4639	101	16	lep	lep	PROPN
ijpds-4639	101	17	-	-	PUNCT
ijpds-4639	101	18	r	r	NOUN
ijpds-4639	101	19	)	)	PUNCT
ijpds-4639	101	20	genes	gene	NOUN
ijpds-4639	101	21	which	which	PRON
ijpds-4639	101	22	has	have	VERB
ijpds-4639	101	23	the	the	DET
ijpds-4639	101	24	capability	capability	NOUN
ijpds-4639	101	25	to	to	PART
ijpds-4639	101	26	disrupt	disrupt	VERB
ijpds-4639	101	27	leptin	leptin	NOUN
ijpds-4639	101	28	functions	function	NOUN
ijpds-4639	101	29	resulting	result	VERB
ijpds-4639	101	30	in	in	ADP
ijpds-4639	101	31	obesity	obesity	NOUN
ijpds-4639	101	32	[	[	X
ijpds-4639	101	33	22][23][24	22][23][24	X
ijpds-4639	101	34	]	]	X
ijpds-4639	101	35	.	.	PUNCT
ijpds-4639	102	1	the	the	DET
ijpds-4639	102	2	polymorphism	polymorphism	NOUN
ijpds-4639	102	3	of	of	ADP
ijpds-4639	102	4	lep-2548	lep-2548	NOUN
ijpds-4639	102	5	g	g	PROPN
ijpds-4639	102	6	/	/	SYM
ijpds-4639	102	7	a	a	PRON
ijpds-4639	102	8	are	be	AUX
ijpds-4639	102	9	widely	widely	ADV
ijpds-4639	102	10	studied	study	VERB
ijpds-4639	102	11	in	in	ADP
ijpds-4639	102	12	humans	human	NOUN
ijpds-4639	102	13	for	for	ADP
ijpds-4639	102	14	understanding	understand	VERB
ijpds-4639	102	15	obesity	obesity	NOUN
ijpds-4639	102	16	.	.	PUNCT
ijpds-4639	103	1	a	a	DET
ijpds-4639	103	2	protein	protein	NOUN
ijpds-4639	103	3	quantitative	quantitative	ADJ
ijpds-4639	103	4	trait	trait	NOUN
ijpds-4639	103	5	locus	locus	NOUN
ijpds-4639	103	6	(	(	PUNCT
ijpds-4639	103	7	pqtl	pqtl	NOUN
ijpds-4639	103	8	)	)	PUNCT
ijpds-4639	103	9	analysis	analysis	NOUN
ijpds-4639	103	10	study	study	NOUN
ijpds-4639	103	11	was	be	AUX
ijpds-4639	103	12	performed	perform	VERB
ijpds-4639	103	13	by	by	ADP
ijpds-4639	103	14	carayol	carayol	PROPN
ijpds-4639	103	15	et	et	PROPN
ijpds-4639	103	16	al	al	PROPN
ijpds-4639	103	17	.	.	PUNCT
ijpds-4639	104	1	to	to	PART
ijpds-4639	104	2	understand	understand	VERB
ijpds-4639	104	3	the	the	DET
ijpds-4639	104	4	genetic	genetic	ADJ
ijpds-4639	104	5	influences	influence	NOUN
ijpds-4639	104	6	on	on	ADP
ijpds-4639	104	7	leptin	leptin	NOUN
ijpds-4639	104	8	levels	level	NOUN
ijpds-4639	104	9	and	and	CCONJ
ijpds-4639	104	10	identified	identify	VERB
ijpds-4639	104	11	fam46a	fam46a	PRON
ijpds-4639	104	12	as	as	ADP
ijpds-4639	104	13	the	the	DET
ijpds-4639	104	14	negative	negative	ADJ
ijpds-4639	104	15	signaling	signal	VERB
ijpds-4639	104	16	regulator	regulator	NOUN
ijpds-4639	104	17	in	in	ADP
ijpds-4639	104	18	adipose	adipose	PRON
ijpds-4639	104	19	tissue	tissue	NOUN
ijpds-4639	105	1	[	[	X
ijpds-4639	105	2	25][26	25][26	NUM
ijpds-4639	105	3	]	]	X
ijpds-4639	105	4	.	.	PUNCT
ijpds-4639	106	1	in	in	ADP
ijpds-4639	106	2	addition	addition	NOUN
ijpds-4639	106	3	to	to	ADP
ijpds-4639	106	4	that	that	DET
ijpds-4639	106	5	distant	distant	ADJ
ijpds-4639	106	6	enhance	enhance	NOUN
ijpds-4639	106	7	sequences	sequence	NOUN
ijpds-4639	106	8	,	,	PUNCT
ijpds-4639	106	9	le1	le1	NOUN
ijpds-4639	106	10	and	and	CCONJ
ijpds-4639	106	11	leprei	leprei	NOUN
ijpds-4639	106	12	,	,	PUNCT
ijpds-4639	106	13	modulate	modulate	VERB
ijpds-4639	106	14	leptin	leptin	NOUN
ijpds-4639	106	15	gene	gene	NOUN
ijpds-4639	106	16	expression	expression	NOUN
ijpds-4639	106	17	through	through	ADP
ijpds-4639	106	18	ppar	ppar	NOUN
ijpds-4639	106	19	gama/	gama/	NUM
ijpds-4639	106	20	rxra	rxra	VERB
ijpds-4639	106	21	binding	bind	VERB
ijpds-4639	106	22	sites	site	NOUN
ijpds-4639	106	23	.	.	PUNCT
ijpds-4639	107	1	noncoding	noncode	VERB
ijpds-4639	107	2	rnas	rna	NOUN
ijpds-4639	107	3	and	and	CCONJ
ijpds-4639	107	4	epigenetic	epigenetic	ADJ
ijpds-4639	107	5	factors	factor	NOUN
ijpds-4639	107	6	like	like	ADP
ijpds-4639	107	7	dna	dna	PROPN
ijpds-4639	107	8	methylation	methylation	NOUN
ijpds-4639	107	9	found	find	VERB
ijpds-4639	107	10	in	in	ADP
ijpds-4639	107	11	the	the	DET
ijpds-4639	107	12	leptin	leptin	NOUN
ijpds-4639	107	13	(	(	PUNCT
ijpds-4639	107	14	ob	ob	NOUN
ijpds-4639	107	15	)	)	PUNCT
ijpds-4639	107	16	and	and	CCONJ
ijpds-4639	107	17	lep	lep	PROPN
ijpds-4639	107	18	-	-	PUNCT
ijpds-4639	107	19	r	r	NOUN
ijpds-4639	107	20	genes	gene	NOUN
ijpds-4639	107	21	,	,	PUNCT
ijpds-4639	107	22	are	be	AUX
ijpds-4639	107	23	expressions	expression	NOUN
ijpds-4639	107	24	of	of	ADP
ijpds-4639	107	25	obesity	obesity	NOUN
ijpds-4639	107	26	and	and	CCONJ
ijpds-4639	107	27	leptin	leptin	NOUN
ijpds-4639	107	28	insensitivity	insensitivity	NOUN
ijpds-4639	107	29	[	[	X
ijpds-4639	107	30	27][28	27][28	PROPN
ijpds-4639	107	31	]	]	PUNCT
ijpds-4639	107	32	.	.	PUNCT
ijpds-4639	108	1	mechanisms	mechanism	NOUN
ijpds-4639	108	2	underpinning	underpin	VERB
ijpds-4639	108	3	leptin	leptin	NOUN
ijpds-4639	108	4	resistance	resistance	NOUN
ijpds-4639	108	5	:	:	PUNCT
ijpds-4639	108	6	it	it	PRON
ijpds-4639	108	7	is	be	AUX
ijpds-4639	108	8	worth	worth	ADJ
ijpds-4639	108	9	noting	note	VERB
ijpds-4639	108	10	that	that	SCONJ
ijpds-4639	108	11	leptin	leptin	NOUN
ijpds-4639	108	12	resistance	resistance	NOUN
ijpds-4639	108	13	occurs	occur	VERB
ijpds-4639	108	14	when	when	SCONJ
ijpds-4639	108	15	there	there	PRON
ijpds-4639	108	16	is	be	VERB
ijpds-4639	108	17	an	an	DET
ijpds-4639	108	18	impairment	impairment	NOUN
ijpds-4639	108	19	of	of	ADP
ijpds-4639	108	20	the	the	DET
ijpds-4639	108	21	effectiveness	effectiveness	NOUN
ijpds-4639	108	22	of	of	ADP
ijpds-4639	108	23	the	the	DET
ijpds-4639	108	24	obrb	obrb	ADJ
ijpds-4639	108	25	downstream	downstream	ADJ
ijpds-4639	108	26	signaling	signal	VERB
ijpds-4639	108	27	transduction	transduction	NOUN
ijpds-4639	108	28	,	,	PUNCT
ijpds-4639	108	29	although	although	SCONJ
ijpds-4639	108	30	in	in	ADP
ijpds-4639	108	31	the	the	DET
ijpds-4639	108	32	presence	presence	NOUN
ijpds-4639	108	33	of	of	ADP
ijpds-4639	108	34	hyperleptinemia	hyperleptinemia	NOUN
ijpds-4639	108	35	,	,	PUNCT
ijpds-4639	108	36	a	a	DET
ijpds-4639	108	37	lack	lack	NOUN
ijpds-4639	108	38	of	of	ADP
ijpds-4639	108	39	anti	anti	ADJ
ijpds-4639	108	40	obesity	obesity	NOUN
ijpds-4639	108	41	action	action	NOUN
ijpds-4639	108	42	of	of	ADP
ijpds-4639	108	43	leptin	leptin	NOUN
ijpds-4639	108	44	appears	appear	VERB
ijpds-4639	108	45	.	.	PUNCT
ijpds-4639	109	1	therefore	therefore	ADV
ijpds-4639	109	2	,	,	PUNCT
ijpds-4639	109	3	leptin	leptin	NOUN
ijpds-4639	109	4	resistance	resistance	NOUN
ijpds-4639	109	5	is	be	AUX
ijpds-4639	109	6	one	one	NUM
ijpds-4639	109	7	of	of	ADP
ijpds-4639	109	8	the	the	DET
ijpds-4639	109	9	most	most	ADV
ijpds-4639	109	10	frequent	frequent	ADJ
ijpds-4639	109	11	features	feature	NOUN
ijpds-4639	109	12	in	in	ADP
ijpds-4639	109	13	the	the	DET
ijpds-4639	109	14	onset	onset	NOUN
ijpds-4639	109	15	and	and	CCONJ
ijpds-4639	109	16	progression	progression	NOUN
ijpds-4639	109	17	of	of	ADP
ijpds-4639	109	18	obesity	obesity	NOUN
ijpds-4639	109	19	[	[	X
ijpds-4639	109	20	29	29	NUM
ijpds-4639	109	21	]	]	PUNCT
ijpds-4639	109	22	.	.	PUNCT
ijpds-4639	110	1	this	this	DET
ijpds-4639	110	2	condition	condition	NOUN
ijpds-4639	110	3	is	be	AUX
ijpds-4639	110	4	very	very	ADV
ijpds-4639	110	5	common	common	ADJ
ijpds-4639	110	6	in	in	ADP
ijpds-4639	110	7	obese	obese	ADJ
ijpds-4639	110	8	humans	human	NOUN
ijpds-4639	110	9	and	and	CCONJ
ijpds-4639	110	10	occurs	occur	VERB
ijpds-4639	110	11	after	after	ADP
ijpds-4639	110	12	only	only	ADV
ijpds-4639	110	13	few	few	ADJ
ijpds-4639	110	14	weeks	week	NOUN
ijpds-4639	110	15	of	of	ADP
ijpds-4639	110	16	high	high	ADJ
ijpds-4639	110	17	fat	fat	ADJ
ijpds-4639	110	18	diet	diet	NOUN
ijpds-4639	110	19	(	(	PUNCT
ijpds-4639	110	20	hfd	hfd	PROPN
ijpds-4639	110	21	)	)	PUNCT
ijpds-4639	110	22	in	in	ADP
ijpds-4639	110	23	rodents	rodent	NOUN
ijpds-4639	110	24	.	.	PUNCT
ijpds-4639	111	1	since	since	SCONJ
ijpds-4639	111	2	the	the	DET
ijpds-4639	111	3	hypothalamus	hypothalamus	PROPN
ijpds-4639	111	4	mediates	mediate	VERB
ijpds-4639	111	5	the	the	DET
ijpds-4639	111	6	anti	anti	ADJ
ijpds-4639	111	7	-	-	ADJ
ijpds-4639	111	8	obesity	obesity	ADJ
ijpds-4639	111	9	actions	action	NOUN
ijpds-4639	111	10	of	of	ADP
ijpds-4639	111	11	leptin	leptin	NOUN
ijpds-4639	111	12	,	,	PUNCT
ijpds-4639	111	13	three	three	NUM
ijpds-4639	111	14	mechanisms	mechanism	NOUN
ijpds-4639	111	15	are	be	AUX
ijpds-4639	111	16	currently	currently	ADV
ijpds-4639	111	17	accepted	accept	VERB
ijpds-4639	111	18	to	to	PART
ijpds-4639	111	19	mediate	mediate	VERB
ijpds-4639	111	20	central	central	ADJ
ijpds-4639	111	21	leptin	leptin	NOUN
ijpds-4639	111	22	resistance	resistance	NOUN
ijpds-4639	111	23	,	,	PUNCT
ijpds-4639	111	24	such	such	ADJ
ijpds-4639	111	25	as	as	ADP
ijpds-4639	111	26	the	the	DET
ijpds-4639	111	27	reduction	reduction	NOUN
ijpds-4639	111	28	in	in	ADP
ijpds-4639	111	29	leptin	leptin	NOUN
ijpds-4639	111	30	access	access	NOUN
ijpds-4639	111	31	to	to	ADP
ijpds-4639	111	32	cns	cns	NOUN
ijpds-4639	111	33	through	through	ADP
ijpds-4639	111	34	the	the	DET
ijpds-4639	111	35	bbb	bbb	PROPN
ijpds-4639	111	36	,	,	PUNCT
ijpds-4639	111	37	the	the	DET
ijpds-4639	111	38	impairment	impairment	NOUN
ijpds-4639	111	39	of	of	ADP
ijpds-4639	111	40	leptin	leptin	NOUN
ijpds-4639	111	41	signaling	signal	VERB
ijpds-4639	111	42	in	in	ADP
ijpds-4639	111	43	firstorder	firstorder	NOUN
ijpds-4639	111	44	neurons	neuron	NOUN
ijpds-4639	111	45	expressing	express	VERB
ijpds-4639	111	46	obrb	obrb	VERB
ijpds-4639	111	47	,	,	PUNCT
ijpds-4639	111	48	or	or	CCONJ
ijpds-4639	111	49	in	in	ADP
ijpds-4639	111	50	second	second	ADJ
ijpds-4639	111	51	-	-	PUNCT
ijpds-4639	111	52	order	order	NOUN
ijpds-4639	111	53	leptintargeted	leptintargeted	ADJ
ijpds-4639	111	54	neurons	neuron	NOUN
ijpds-4639	111	55	and	and	CCONJ
ijpds-4639	111	56	neural	neural	ADJ
ijpds-4639	111	57	circuits	circuit	NOUN
ijpds-4639	111	58	.	.	PUNCT
ijpds-4639	112	1	it	it	PRON
ijpds-4639	112	2	has	have	AUX
ijpds-4639	112	3	been	be	AUX
ijpds-4639	112	4	recently	recently	ADV
ijpds-4639	112	5	suggested	suggest	VERB
ijpds-4639	112	6	that	that	SCONJ
ijpds-4639	112	7	other	other	ADJ
ijpds-4639	112	8	mechanisms	mechanism	NOUN
ijpds-4639	112	9	,	,	PUNCT
ijpds-4639	112	10	such	such	ADJ
ijpds-4639	112	11	as	as	ADP
ijpds-4639	112	12	the	the	DET
ijpds-4639	112	13	onset	onset	NOUN
ijpds-4639	112	14	of	of	ADP
ijpds-4639	112	15	hypothalamic	hypothalamic	ADJ
ijpds-4639	112	16	inflammation	inflammation	NOUN
ijpds-4639	112	17	,	,	PUNCT
ijpds-4639	112	18	autophagy	autophagy	ADJ
ijpds-4639	112	19	deficiency	deficiency	NOUN
ijpds-4639	112	20	or	or	CCONJ
ijpds-4639	112	21	er	er	INTJ
ijpds-4639	112	22	stress	stress	NOUN
ijpds-4639	112	23	,	,	PUNCT
ijpds-4639	112	24	can	can	AUX
ijpds-4639	112	25	also	also	ADV
ijpds-4639	112	26	mediate	mediate	VERB
ijpds-4639	112	27	the	the	DET
ijpds-4639	112	28	obesityassociated	obesityassociate	VERB
ijpds-4639	112	29	central	central	ADJ
ijpds-4639	112	30	leptin	leptin	NOUN
ijpds-4639	112	31	resistance	resistance	NOUN
ijpds-4639	112	32	.	.	PUNCT
ijpds-4639	113	1	indeed	indeed	ADV
ijpds-4639	113	2	,	,	PUNCT
ijpds-4639	113	3	since	since	SCONJ
ijpds-4639	113	4	leptin	leptin	NOUN
ijpds-4639	113	5	exerts	exert	VERB
ijpds-4639	113	6	its	its	PRON
ijpds-4639	113	7	biological	biological	ADJ
ijpds-4639	113	8	effects	effect	NOUN
ijpds-4639	113	9	not	not	PART
ijpds-4639	113	10	only	only	ADV
ijpds-4639	113	11	in	in	ADP
ijpds-4639	113	12	cns	cns	NOUN
ijpds-4639	113	13	but	but	CCONJ
ijpds-4639	113	14	also	also	ADV
ijpds-4639	113	15	in	in	ADP
ijpds-4639	113	16	peripheral	peripheral	ADJ
ijpds-4639	113	17	tissues	tissue	NOUN
ijpds-4639	113	18	,	,	PUNCT
ijpds-4639	113	19	parallel	parallel	ADJ
ijpds-4639	113	20	to	to	ADP
ijpds-4639	113	21	central	central	ADJ
ijpds-4639	113	22	leptin	leptin	NOUN
ijpds-4639	113	23	resistance	resistance	NOUN
ijpds-4639	113	24	a	a	DET
ijpds-4639	113	25	peripheral	peripheral	ADJ
ijpds-4639	113	26	dampening	dampening	NOUN
ijpds-4639	113	27	in	in	ADP
ijpds-4639	113	28	leptin	leptin	NOUN
ijpds-4639	113	29	sensitivity	sensitivity	NOUN
ijpds-4639	113	30	can	can	AUX
ijpds-4639	113	31	occur	occur	VERB
ijpds-4639	113	32	.	.	PUNCT
ijpds-4639	114	1	reduction	reduction	NOUN
ijpds-4639	114	2	in	in	ADP
ijpds-4639	114	3	leptin	leptin	NOUN
ijpds-4639	114	4	access	access	NOUN
ijpds-4639	114	5	to	to	ADP
ijpds-4639	114	6	cns	cns	NOUN
ijpds-4639	114	7	:	:	PUNCT
ijpds-4639	114	8	as	as	SCONJ
ijpds-4639	114	9	it	it	PRON
ijpds-4639	114	10	is	be	AUX
ijpds-4639	114	11	well	well	ADV
ijpds-4639	114	12	-	-	PUNCT
ijpds-4639	114	13	known	know	VERB
ijpds-4639	114	14	,	,	PUNCT
ijpds-4639	114	15	obra	obra	PROPN
ijpds-4639	114	16	,	,	PUNCT
ijpds-4639	114	17	which	which	PRON
ijpds-4639	114	18	is	be	AUX
ijpds-4639	114	19	highly	highly	ADV
ijpds-4639	114	20	expressed	express	VERB
ijpds-4639	114	21	by	by	ADP
ijpds-4639	114	22	capillary	capillary	ADJ
ijpds-4639	114	23	cells	cell	NOUN
ijpds-4639	114	24	of	of	ADP
ijpds-4639	114	25	the	the	DET
ijpds-4639	114	26	choroid	choroid	NOUN
ijpds-4639	114	27	plexus	plexus	NOUN
ijpds-4639	114	28	,	,	PUNCT
ijpds-4639	114	29	actively	actively	ADV
ijpds-4639	114	30	transports	transport	VERB
ijpds-4639	114	31	leptin	leptin	VERB
ijpds-4639	114	32	across	across	ADP
ijpds-4639	114	33	the	the	DET
ijpds-4639	114	34	bbb	bbb	NOUN
ijpds-4639	114	35	to	to	PART
ijpds-4639	114	36	reach	reach	VERB
ijpds-4639	114	37	the	the	DET
ijpds-4639	114	38	majority	majority	NOUN
ijpds-4639	114	39	of	of	ADP
ijpds-4639	114	40	obrb	obrb	ADJ
ijpds-4639	114	41	expressing	express	VERB
ijpds-4639	114	42	neurons	neuron	NOUN
ijpds-4639	114	43	in	in	ADP
ijpds-4639	114	44	the	the	DET
ijpds-4639	114	45	cns	cns	NOUN
ijpds-4639	114	46	.	.	PUNCT
ijpds-4639	115	1	this	this	DET
ijpds-4639	115	2	transport	transport	NOUN
ijpds-4639	115	3	system	system	NOUN
ijpds-4639	115	4	is	be	AUX
ijpds-4639	115	5	saturable	saturable	ADJ
ijpds-4639	115	6	and	and	CCONJ
ijpds-4639	115	7	recently	recently	ADV
ijpds-4639	115	8	it	it	PRON
ijpds-4639	115	9	has	have	AUX
ijpds-4639	115	10	been	be	AUX
ijpds-4639	115	11	shown	show	VERB
ijpds-4639	115	12	to	to	PART
ijpds-4639	115	13	be	be	AUX
ijpds-4639	115	14	flanked	flank	VERB
ijpds-4639	115	15	by	by	ADP
ijpds-4639	115	16	another	another	DET
ijpds-4639	115	17	transport	transport	NOUN
ijpds-4639	115	18	mechanism	mechanism	NOUN
ijpds-4639	115	19	involving	involve	VERB
ijpds-4639	115	20	the	the	DET
ijpds-4639	115	21	endocytic	endocytic	ADJ
ijpds-4639	115	22	receptor	receptor	NOUN
ijpds-4639	115	23	megalin	megalin	NOUN
ijpds-4639	115	24	,	,	PUNCT
ijpds-4639	115	25	as	as	SCONJ
ijpds-4639	115	26	demonstrated	demonstrate	VERB
ijpds-4639	115	27	by	by	ADP
ijpds-4639	115	28	a	a	DET
ijpds-4639	115	29	decrease	decrease	NOUN
ijpds-4639	115	30	in	in	ADP
ijpds-4639	115	31	leptin	leptin	NOUN
ijpds-4639	115	32	cerebrospinal	cerebrospinal	ADJ
ijpds-4639	115	33	fluid	fluid	NOUN
ijpds-4639	115	34	(	(	PUNCT
ijpds-4639	115	35	csf	csf	NOUN
ijpds-4639	115	36	)	)	PUNCT
ijpds-4639	115	37	levels	level	NOUN
ijpds-4639	115	38	inmegalin	inmegalin	NOUN
ijpds-4639	115	39	deficiency	deficiency	NOUN
ijpds-4639	115	40	[	[	X
ijpds-4639	115	41	30	30	NUM
ijpds-4639	115	42	]	]	PUNCT
ijpds-4639	115	43	.	.	PUNCT
ijpds-4639	116	1	in	in	ADP
ijpds-4639	116	2	obese	obese	ADJ
ijpds-4639	116	3	individuals	individual	NOUN
ijpds-4639	116	4	the	the	DET
ijpds-4639	116	5	saturation	saturation	NOUN
ijpds-4639	116	6	of	of	ADP
ijpds-4639	116	7	leptin	leptin	PROPN
ijpds-4639	116	8	singha	singha	PROPN
ijpds-4639	116	9	et	et	PROPN
ijpds-4639	116	10	al	al	PROPN
ijpds-4639	116	11	.	.	PROPN
ijpds-4639	116	12	leptin	leptin	PROPN
ijpds-4639	116	13	:	:	PUNCT
ijpds-4639	116	14	its	its	PRON
ijpds-4639	116	15	crucial	crucial	ADJ
ijpds-4639	116	16	role	role	NOUN
ijpds-4639	116	17	in	in	ADP
ijpds-4639	116	18	the	the	DET
ijpds-4639	116	19	fight	fight	NOUN
ijpds-4639	116	20	against	against	ADP
ijpds-4639	116	21	obesity	obesity	NOUN
ijpds-4639	116	22	online	online	ADJ
ijpds-4639	116	23	first	first	PROPN
ijpds-4639	116	24	indian	indian	PROPN
ijpds-4639	116	25	j	j	PROPN
ijpds-4639	116	26	pharm	pharm	PROPN
ijpds-4639	116	27	drug	drug	PROPN
ijpds-4639	116	28	studies	study	NOUN
ijpds-4639	116	29	|	|	ADV
ijpds-4639	116	30	3	3	NUM
ijpds-4639	116	31	transport	transport	NOUN
ijpds-4639	116	32	can	can	AUX
ijpds-4639	116	33	occur	occur	VERB
ijpds-4639	116	34	due	due	ADP
ijpds-4639	116	35	to	to	ADP
ijpds-4639	116	36	the	the	DET
ijpds-4639	116	37	hyperleptinemia	hyperleptinemia	NOUN
ijpds-4639	116	38	,	,	PUNCT
ijpds-4639	116	39	resulting	result	VERB
ijpds-4639	116	40	in	in	ADP
ijpds-4639	116	41	an	an	DET
ijpds-4639	116	42	only	only	ADJ
ijpds-4639	116	43	slightly	slightly	ADJ
ijpds-4639	116	44	increase	increase	NOUN
ijpds-4639	116	45	in	in	ADP
ijpds-4639	116	46	the	the	DET
ijpds-4639	116	47	csf	csf	ADJ
ijpds-4639	116	48	leptin	leptin	NOUN
ijpds-4639	116	49	levels	level	NOUN
ijpds-4639	116	50	[	[	X
ijpds-4639	116	51	31	31	NUM
ijpds-4639	116	52	]	]	PUNCT
ijpds-4639	116	53	.	.	PUNCT
ijpds-4639	117	1	oh	oh	INTJ
ijpds-4639	117	2	-	-	INTJ
ijpds-4639	117	3	i	i	PRON
ijpds-4639	117	4	et	et	PROPN
ijpds-4639	117	5	al	al	PROPN
ijpds-4639	117	6	.	.	PROPN
ijpds-4639	117	7	showed	show	VERB
ijpds-4639	117	8	that	that	SCONJ
ijpds-4639	117	9	the	the	DET
ijpds-4639	117	10	impairment	impairment	NOUN
ijpds-4639	117	11	of	of	ADP
ijpds-4639	117	12	leptin	leptin	NOUN
ijpds-4639	117	13	transport	transport	NOUN
ijpds-4639	117	14	across	across	ADP
ijpds-4639	117	15	bbb	bbb	PROPN
ijpds-4639	117	16	can	can	AUX
ijpds-4639	117	17	also	also	ADV
ijpds-4639	117	18	be	be	AUX
ijpds-4639	117	19	caused	cause	VERB
ijpds-4639	117	20	by	by	ADP
ijpds-4639	117	21	the	the	DET
ijpds-4639	117	22	higher	high	ADJ
ijpds-4639	117	23	plasmatic	plasmatic	ADJ
ijpds-4639	117	24	levels	level	NOUN
ijpds-4639	117	25	of	of	ADP
ijpds-4639	117	26	cytokines	cytokine	NOUN
ijpds-4639	117	27	figure	figure	VERB
ijpds-4639	117	28	the	the	DET
ijpds-4639	117	29	pathophysiology	pathophysiology	NOUN
ijpds-4639	117	30	of	of	ADP
ijpds-4639	117	31	leptin	leptin	NOUN
ijpds-4639	117	32	signaling	signal	VERB
ijpds-4639	117	33	on	on	ADP
ijpds-4639	117	34	its	its	PRON
ijpds-4639	117	35	crucial	crucial	ADJ
ijpds-4639	117	36	role	role	NOUN
ijpds-4639	117	37	in	in	ADP
ijpds-4639	117	38	regulating	regulate	VERB
ijpds-4639	117	39	appetite	appetite	NOUN
ijpds-4639	117	40	and	and	CCONJ
ijpds-4639	117	41	maintaining	maintain	VERB
ijpds-4639	117	42	energy	energy	NOUN
ijpds-4639	117	43	balance	balance	NOUN
ijpds-4639	117	44	[	[	X
ijpds-4639	117	45	52	52	NUM
ijpds-4639	117	46	]	]	PUNCT
ijpds-4639	117	47	and	and	CCONJ
ijpds-4639	117	48	fatty	fatty	NOUN
ijpds-4639	117	49	acids	acid	NOUN
ijpds-4639	117	50	in	in	ADP
ijpds-4639	117	51	obese	obese	ADJ
ijpds-4639	117	52	individuals	individual	NOUN
ijpds-4639	117	53	relative	relative	ADJ
ijpds-4639	117	54	to	to	ADP
ijpds-4639	117	55	lean	lean	ADJ
ijpds-4639	117	56	subjects	subject	NOUN
ijpds-4639	117	57	.	.	PUNCT
ijpds-4639	118	1	to	to	ADP
ijpds-4639	118	2	date	date	NOUN
ijpds-4639	118	3	,	,	PUNCT
ijpds-4639	118	4	it	it	PRON
ijpds-4639	118	5	is	be	AUX
ijpds-4639	118	6	still	still	ADV
ijpds-4639	118	7	unclear	unclear	ADJ
ijpds-4639	118	8	the	the	DET
ijpds-4639	118	9	extent	extent	NOUN
ijpds-4639	118	10	to	to	PART
ijpds-4639	118	11	which	which	PRON
ijpds-4639	118	12	the	the	DET
ijpds-4639	118	13	impairment	impairment	NOUN
ijpds-4639	118	14	of	of	ADP
ijpds-4639	118	15	leptin	leptin	NOUN
ijpds-4639	118	16	transport	transport	NOUN
ijpds-4639	118	17	to	to	ADP
ijpds-4639	118	18	cns	cns	PROPN
ijpds-4639	118	19	can	can	AUX
ijpds-4639	118	20	contribute	contribute	VERB
ijpds-4639	118	21	to	to	ADP
ijpds-4639	118	22	the	the	DET
ijpds-4639	118	23	leptin	leptin	NOUN
ijpds-4639	118	24	resistance	resistance	NOUN
ijpds-4639	118	25	.	.	PUNCT
ijpds-4639	119	1	indeed	indeed	ADV
ijpds-4639	119	2	,	,	PUNCT
ijpds-4639	119	3	leptin	leptin	NOUN
ijpds-4639	119	4	can	can	AUX
ijpds-4639	119	5	reach	reach	VERB
ijpds-4639	119	6	the	the	DET
ijpds-4639	119	7	cns	cns	NOUN
ijpds-4639	119	8	through	through	ADP
ijpds-4639	119	9	the	the	DET
ijpds-4639	119	10	median	median	ADJ
ijpds-4639	119	11	eminence	eminence	NOUN
ijpds-4639	119	12	,	,	PUNCT
ijpds-4639	119	13	which	which	PRON
ijpds-4639	119	14	lacks	lack	VERB
ijpds-4639	119	15	the	the	DET
ijpds-4639	119	16	bbb	bbb	PROPN
ijpds-4639	119	17	.	.	PUNCT
ijpds-4639	120	1	therefore	therefore	ADV
ijpds-4639	120	2	,	,	PUNCT
ijpds-4639	120	3	arc	arc	NOUN
ijpds-4639	120	4	firstorder	firstorder	NOUN
ijpds-4639	120	5	neurons	neuron	NOUN
ijpds-4639	120	6	can	can	AUX
ijpds-4639	120	7	sense	sense	VERB
ijpds-4639	120	8	leptin	leptin	VERB
ijpds-4639	120	9	trough	trough	NOUN
ijpds-4639	120	10	their	their	PRON
ijpds-4639	120	11	projections	projection	NOUN
ijpds-4639	120	12	into	into	ADP
ijpds-4639	120	13	the	the	DET
ijpds-4639	120	14	median	median	ADJ
ijpds-4639	120	15	eminence	eminence	NOUN
ijpds-4639	120	16	[	[	X
ijpds-4639	120	17	32	32	NUM
ijpds-4639	120	18	]	]	PUNCT
ijpds-4639	120	19	.	.	PUNCT
ijpds-4639	121	1	impairment	impairment	NOUN
ijpds-4639	121	2	of	of	ADP
ijpds-4639	121	3	leptin	leptin	NOUN
ijpds-4639	121	4	signaling	signal	VERB
ijpds-4639	121	5	in	in	ADP
ijpds-4639	121	6	hypothalamic	hypothalamic	ADJ
ijpds-4639	121	7	neurons	neuron	NOUN
ijpds-4639	121	8	:	:	PUNCT
ijpds-4639	121	9	leptin	leptin	NOUN
ijpds-4639	121	10	resistance	resistance	NOUN
ijpds-4639	121	11	can	can	AUX
ijpds-4639	121	12	occur	occur	VERB
ijpds-4639	121	13	by	by	ADP
ijpds-4639	121	14	alterations	alteration	NOUN
ijpds-4639	121	15	in	in	ADP
ijpds-4639	121	16	each	each	DET
ijpds-4639	121	17	component	component	NOUN
ijpds-4639	121	18	of	of	ADP
ijpds-4639	121	19	the	the	DET
ijpds-4639	121	20	ob	ob	NOUN
ijpds-4639	121	21	-	-	PUNCT
ijpds-4639	121	22	rb	rb	NOUN
ijpds-4639	121	23	downstream	downstream	ADJ
ijpds-4639	121	24	signaling	signal	VERB
ijpds-4639	121	25	cascade	cascade	NOUN
ijpds-4639	121	26	.	.	PUNCT
ijpds-4639	122	1	in	in	ADP
ijpds-4639	122	2	particular	particular	ADJ
ijpds-4639	122	3	,	,	PUNCT
ijpds-4639	122	4	previous	previous	ADJ
ijpds-4639	122	5	findings	finding	NOUN
ijpds-4639	122	6	have	have	AUX
ijpds-4639	122	7	highlighted	highlight	VERB
ijpds-4639	122	8	three	three	NUM
ijpds-4639	122	9	potential	potential	ADJ
ijpds-4639	122	10	mechanisms	mechanism	NOUN
ijpds-4639	122	11	:	:	PUNCT
ijpds-4639	122	12	a	a	DET
ijpds-4639	122	13	reduced	reduced	ADJ
ijpds-4639	122	14	expression	expression	NOUN
ijpds-4639	122	15	of	of	ADP
ijpds-4639	122	16	ob	ob	NOUN
ijpds-4639	122	17	-	-	NOUN
ijpds-4639	122	18	rb	rb	NOUN
ijpds-4639	122	19	at	at	ADP
ijpds-4639	122	20	plasma	plasma	NOUN
ijpds-4639	122	21	membrane	membrane	NOUN
ijpds-4639	122	22	level	level	NOUN
ijpds-4639	122	23	,	,	PUNCT
ijpds-4639	122	24	an	an	DET
ijpds-4639	122	25	upregulation	upregulation	NOUN
ijpds-4639	122	26	of	of	ADP
ijpds-4639	122	27	negative	negative	ADJ
ijpds-4639	122	28	regulators	regulator	NOUN
ijpds-4639	122	29	of	of	ADP
ijpds-4639	122	30	leptin	leptin	NOUN
ijpds-4639	122	31	signaling	signal	VERB
ijpds-4639	122	32	,	,	PUNCT
ijpds-4639	122	33	and	and	CCONJ
ijpds-4639	122	34	a	a	DET
ijpds-4639	122	35	downregulation	downregulation	NOUN
ijpds-4639	122	36	of	of	ADP
ijpds-4639	122	37	its	its	PRON
ijpds-4639	122	38	positive	positive	ADJ
ijpds-4639	122	39	regulators	regulator	NOUN
ijpds-4639	122	40	.	.	PUNCT
ijpds-4639	123	1	diano	diano	PROPN
ijpds-4639	123	2	et	et	PROPN
ijpds-4639	123	3	al	al	PROPN
ijpds-4639	123	4	.	.	PROPN
ijpds-4639	123	5	have	have	AUX
ijpds-4639	123	6	demonstrated	demonstrate	VERB
ijpds-4639	123	7	that	that	SCONJ
ijpds-4639	123	8	ob	ob	NOUN
ijpds-4639	123	9	-	-	NOUN
ijpds-4639	123	10	rb	rb	NOUN
ijpds-4639	123	11	has	have	VERB
ijpds-4639	123	12	a	a	DET
ijpds-4639	123	13	predominant	predominant	ADJ
ijpds-4639	123	14	localization	localization	NOUN
ijpds-4639	123	15	in	in	ADP
ijpds-4639	123	16	the	the	DET
ijpds-4639	123	17	golgi	golgi	NOUN
ijpds-4639	123	18	apparatus	apparatus	NOUN
ijpds-4639	123	19	in	in	ADP
ijpds-4639	123	20	hypothalamic	hypothalamic	ADJ
ijpds-4639	123	21	neuronal	neuronal	ADJ
ijpds-4639	123	22	and	and	CCONJ
ijpds-4639	123	23	glial	glial	ADJ
ijpds-4639	123	24	cells	cell	NOUN
ijpds-4639	123	25	,	,	PUNCT
ijpds-4639	123	26	thus	thus	ADV
ijpds-4639	123	27	its	its	PRON
ijpds-4639	123	28	trafficking	trafficking	NOUN
ijpds-4639	123	29	to	to	ADP
ijpds-4639	123	30	the	the	DET
ijpds-4639	123	31	plasma	plasma	NOUN
ijpds-4639	123	32	membrane	membrane	NOUN
ijpds-4639	123	33	is	be	AUX
ijpds-4639	123	34	necessary	necessary	ADJ
ijpds-4639	123	35	to	to	PART
ijpds-4639	123	36	obtain	obtain	VERB
ijpds-4639	123	37	a	a	DET
ijpds-4639	123	38	physiological	physiological	ADJ
ijpds-4639	123	39	response	response	NOUN
ijpds-4639	123	40	to	to	PART
ijpds-4639	123	41	leptin	leptin	NOUN
ijpds-4639	123	42	stimulation	stimulation	NOUN
ijpds-4639	123	43	.	.	PUNCT
ijpds-4639	124	1	the	the	DET
ijpds-4639	124	2	ob	ob	NOUN
ijpds-4639	124	3	-	-	PUNCT
ijpds-4639	124	4	rb	rb	NOUN
ijpds-4639	124	5	expression	expression	NOUN
ijpds-4639	124	6	pattern	pattern	NOUN
ijpds-4639	124	7	at	at	ADP
ijpds-4639	124	8	cell	cell	NOUN
ijpds-4639	124	9	surface	surface	NOUN
ijpds-4639	124	10	depends	depend	VERB
ijpds-4639	124	11	on	on	ADP
ijpds-4639	124	12	a	a	DET
ijpds-4639	124	13	delicate	delicate	ADJ
ijpds-4639	124	14	balance	balance	NOUN
ijpds-4639	124	15	between	between	ADP
ijpds-4639	124	16	the	the	DET
ijpds-4639	124	17	activity	activity	NOUN
ijpds-4639	124	18	of	of	ADP
ijpds-4639	124	19	the	the	DET
ijpds-4639	124	20	bardet	bardet	NOUN
ijpds-4639	124	21	-	-	PUNCT
ijpds-4639	124	22	biedl	biedl	PROPN
ijpds-4639	124	23	syndrome	syndrome	PROPN
ijpds-4639	124	24	(	(	PUNCT
ijpds-4639	124	25	bbs	bbs	PROPN
ijpds-4639	124	26	)	)	PUNCT
ijpds-4639	124	27	proteins	protein	NOUN
ijpds-4639	124	28	,	,	PUNCT
ijpds-4639	124	29	which	which	PRON
ijpds-4639	124	30	mediate	mediate	VERB
ijpds-4639	124	31	its	its	PRON
ijpds-4639	124	32	transport	transport	NOUN
ijpds-4639	124	33	to	to	ADP
ijpds-4639	124	34	the	the	DET
ijpds-4639	124	35	plasma	plasma	NOUN
ijpds-4639	124	36	membrane	membrane	NOUN
ijpds-4639	124	37	,	,	PUNCT
ijpds-4639	124	38	and	and	CCONJ
ijpds-4639	124	39	the	the	DET
ijpds-4639	124	40	rate	rate	NOUN
ijpds-4639	124	41	of	of	ADP
ijpds-4639	124	42	the	the	DET
ijpds-4639	124	43	ligand	ligand	ADJ
ijpds-4639	124	44	independent	independent	ADJ
ijpds-4639	124	45	endocytosis	endocytosis	NOUN
ijpds-4639	124	46	,	,	PUNCT
ijpds-4639	124	47	a	a	DET
ijpds-4639	124	48	process	process	NOUN
ijpds-4639	124	49	that	that	PRON
ijpds-4639	124	50	promotes	promote	VERB
ijpds-4639	124	51	the	the	DET
ijpds-4639	124	52	ob	ob	NOUN
ijpds-4639	124	53	-	-	PUNCT
ijpds-4639	124	54	rb	rb	NOUN
ijpds-4639	124	55	internalization	internalization	NOUN
ijpds-4639	124	56	.	.	PUNCT
ijpds-4639	125	1	regarding	regard	VERB
ijpds-4639	125	2	the	the	DET
ijpds-4639	125	3	second	second	ADJ
ijpds-4639	125	4	molecular	molecular	ADJ
ijpds-4639	125	5	mechanism	mechanism	NOUN
ijpds-4639	125	6	underpinning	underpin	VERB
ijpds-4639	125	7	leptin	leptin	NOUN
ijpds-4639	125	8	resistance	resistance	NOUN
ijpds-4639	125	9	,	,	PUNCT
ijpds-4639	125	10	the	the	DET
ijpds-4639	125	11	ob	ob	NOUN
ijpds-4639	125	12	-	-	PUNCT
ijpds-4639	125	13	rb	rb	ADJ
ijpds-4639	125	14	physiological	physiological	ADJ
ijpds-4639	125	15	signaling	signaling	NOUN
ijpds-4639	125	16	is	be	AUX
ijpds-4639	125	17	under	under	ADP
ijpds-4639	125	18	control	control	NOUN
ijpds-4639	125	19	of	of	ADP
ijpds-4639	125	20	two	two	NUM
ijpds-4639	125	21	negative	negative	ADJ
ijpds-4639	125	22	regulators	regulator	NOUN
ijpds-4639	125	23	:	:	PUNCT
ijpds-4639	125	24	socs-3	socs-3	NUM
ijpds-4639	125	25	and	and	CCONJ
ijpds-4639	125	26	phosphor	phosphor	NOUN
ijpds-4639	125	27	tyrosine	tyrosine	NOUN
ijpds-4639	125	28	phosphatase	phosphatase	NOUN
ijpds-4639	125	29	(	(	PUNCT
ijpds-4639	125	30	ptp	ptp	PROPN
ijpds-4639	125	31	)	)	PUNCT
ijpds-4639	125	32	1b	1b	NOUN
ijpds-4639	126	1	[	[	X
ijpds-4639	126	2	33	33	NUM
ijpds-4639	126	3	]	]	PUNCT
ijpds-4639	126	4	.	.	PUNCT
ijpds-4639	127	1	socs3	socs3	PROPN
ijpds-4639	127	2	is	be	AUX
ijpds-4639	127	3	involved	involve	VERB
ijpds-4639	127	4	in	in	ADP
ijpds-4639	127	5	the	the	DET
ijpds-4639	127	6	onset	onset	NOUN
ijpds-4639	127	7	of	of	ADP
ijpds-4639	127	8	leptin	leptin	NOUN
ijpds-4639	127	9	resistance	resistance	NOUN
ijpds-4639	127	10	at	at	ADP
ijpds-4639	127	11	central	central	ADJ
ijpds-4639	127	12	level	level	NOUN
ijpds-4639	127	13	,	,	PUNCT
ijpds-4639	127	14	as	as	ADV
ijpds-4639	127	15	well	well	ADV
ijpds-4639	127	16	as	as	ADP
ijpds-4639	127	17	at	at	ADP
ijpds-4639	127	18	peripheral	peripheral	ADJ
ijpds-4639	127	19	level	level	NOUN
ijpds-4639	127	20	.	.	PUNCT
ijpds-4639	128	1	it	it	PRON
ijpds-4639	128	2	has	have	AUX
ijpds-4639	128	3	been	be	AUX
ijpds-4639	128	4	demonstrated	demonstrate	VERB
ijpds-4639	128	5	that	that	SCONJ
ijpds-4639	128	6	an	an	DET
ijpds-4639	128	7	increase	increase	NOUN
ijpds-4639	128	8	in	in	ADP
ijpds-4639	128	9	socs3	socs3	ADJ
ijpds-4639	128	10	mrna	mrna	NOUN
ijpds-4639	128	11	expression	expression	NOUN
ijpds-4639	128	12	is	be	AUX
ijpds-4639	128	13	involved	involve	VERB
ijpds-4639	128	14	in	in	ADP
ijpds-4639	128	15	the	the	DET
ijpds-4639	128	16	development	development	NOUN
ijpds-4639	128	17	of	of	ADP
ijpds-4639	128	18	leptin	leptin	NOUN
ijpds-4639	128	19	resistance	resistance	NOUN
ijpds-4639	128	20	in	in	ADP
ijpds-4639	128	21	skeletal	skeletal	ADJ
ijpds-4639	128	22	muscle	muscle	NOUN
ijpds-4639	128	23	from	from	ADP
ijpds-4639	128	24	rats	rat	NOUN
ijpds-4639	128	25	on	on	ADP
ijpds-4639	128	26	high	high	ADJ
ijpds-4639	128	27	-	-	PUNCT
ijpds-4639	128	28	fat	fat	NOUN
ijpds-4639	128	29	diet	diet	NOUN
ijpds-4639	128	30	(	(	PUNCT
ijpds-4639	128	31	hfd	hfd	PROPN
ijpds-4639	128	32	)	)	PUNCT
ijpds-4639	128	33	.	.	PUNCT
ijpds-4639	129	1	moreover	moreover	ADV
ijpds-4639	129	2	,	,	PUNCT
ijpds-4639	129	3	socs3	socs3	PROPN
ijpds-4639	129	4	inhibits	inhibit	VERB
ijpds-4639	129	5	ampk	ampk	NOUN
ijpds-4639	129	6	activation	activation	NOUN
ijpds-4639	129	7	in	in	ADP
ijpds-4639	129	8	peripheral	peripheral	ADJ
ijpds-4639	129	9	metabolically	metabolically	NOUN
ijpds-4639	129	10	active	active	ADJ
ijpds-4639	129	11	tissues	tissue	NOUN
ijpds-4639	129	12	,	,	PUNCT
ijpds-4639	129	13	such	such	DET
ijpds-4639	129	14	the	the	DET
ijpds-4639	129	15	liver	liver	NOUN
ijpds-4639	129	16	,	,	PUNCT
ijpds-4639	129	17	white	white	ADJ
ijpds-4639	129	18	adipose	adipose	PRON
ijpds-4639	129	19	tissue	tissue	NOUN
ijpds-4639	129	20	(	(	PUNCT
ijpds-4639	129	21	wat	wat	NOUN
ijpds-4639	129	22	)	)	PUNCT
ijpds-4639	129	23	and	and	CCONJ
ijpds-4639	129	24	skeletal	skeletal	ADJ
ijpds-4639	129	25	muscle	muscle	NOUN
ijpds-4639	129	26	,	,	PUNCT
ijpds-4639	129	27	contributing	contribute	VERB
ijpds-4639	129	28	to	to	ADP
ijpds-4639	129	29	abnormalities	abnormality	NOUN
ijpds-4639	129	30	of	of	ADP
ijpds-4639	129	31	fatty	fatty	NOUN
ijpds-4639	129	32	acid	acid	ADJ
ijpds-4639	129	33	metabolism	metabolism	NOUN
ijpds-4639	129	34	.	.	PUNCT
ijpds-4639	130	1	ampk	ampk	NOUN
ijpds-4639	130	2	is	be	AUX
ijpds-4639	130	3	a	a	DET
ijpds-4639	130	4	fuel	fuel	NOUN
ijpds-4639	130	5	-	-	PUNCT
ijpds-4639	130	6	sensing	sense	VERB
ijpds-4639	130	7	enzyme	enzyme	NOUN
ijpds-4639	130	8	,	,	PUNCT
ijpds-4639	130	9	whose	whose	DET
ijpds-4639	130	10	activity	activity	NOUN
ijpds-4639	130	11	is	be	AUX
ijpds-4639	130	12	finely	finely	ADV
ijpds-4639	130	13	regulated	regulate	VERB
ijpds-4639	130	14	by	by	ADP
ijpds-4639	130	15	leptin	leptin	NOUN
ijpds-4639	130	16	:	:	PUNCT
ijpds-4639	130	17	in	in	ADP
ijpds-4639	130	18	peripheral	peripheral	ADJ
ijpds-4639	130	19	tissues	tissue	NOUN
ijpds-4639	130	20	,	,	PUNCT
ijpds-4639	130	21	i.e.	i.e.	X
ijpds-4639	130	22	wat	wat	X
ijpds-4639	130	23	,	,	PUNCT
ijpds-4639	130	24	leptin	leptin	NOUN
ijpds-4639	130	25	increases	increase	VERB
ijpds-4639	130	26	its	its	PRON
ijpds-4639	130	27	enzyme	enzyme	NOUN
ijpds-4639	130	28	activity	activity	NOUN
ijpds-4639	130	29	,	,	PUNCT
ijpds-4639	130	30	promoting	promote	VERB
ijpds-4639	130	31	the	the	DET
ijpds-4639	130	32	catabolic	catabolic	ADJ
ijpds-4639	130	33	pathways	pathway	NOUN
ijpds-4639	130	34	toward	toward	ADP
ijpds-4639	130	35	the	the	DET
ijpds-4639	130	36	fatty	fatty	NOUN
ijpds-4639	130	37	acid	acid	NOUN
ijpds-4639	130	38	oxidation	oxidation	NOUN
ijpds-4639	130	39	and	and	CCONJ
ijpds-4639	130	40	glucose	glucose	NOUN
ijpds-4639	130	41	internalization	internalization	NOUN
ijpds-4639	130	42	,	,	PUNCT
ijpds-4639	130	43	exceeding	exceed	VERB
ijpds-4639	130	44	the	the	DET
ijpds-4639	130	45	anabolism	anabolism	NOUN
ijpds-4639	130	46	rate	rate	NOUN
ijpds-4639	130	47	.	.	PUNCT
ijpds-4639	131	1	on	on	ADP
ijpds-4639	131	2	the	the	DET
ijpds-4639	131	3	contrary	contrary	NOUN
ijpds-4639	131	4	,	,	PUNCT
ijpds-4639	131	5	leptin	leptin	NOUN
ijpds-4639	131	6	inhibits	inhibit	VERB
ijpds-4639	131	7	ampk	ampk	NOUN
ijpds-4639	131	8	activity	activity	NOUN
ijpds-4639	131	9	at	at	ADP
ijpds-4639	131	10	central	central	ADJ
ijpds-4639	131	11	level	level	NOUN
ijpds-4639	131	12	,	,	PUNCT
ijpds-4639	131	13	where	where	SCONJ
ijpds-4639	131	14	this	this	DET
ijpds-4639	131	15	enzyme	enzyme	NOUN
ijpds-4639	131	16	is	be	AUX
ijpds-4639	131	17	involved	involve	VERB
ijpds-4639	131	18	in	in	ADP
ijpds-4639	131	19	food	food	NOUN
ijpds-4639	131	20	intake	intake	NOUN
ijpds-4639	131	21	regulation	regulation	PROPN
ijpds-4639	131	22	,	,	PUNCT
ijpds-4639	132	1	singha	singha	PROPN
ijpds-4639	132	2	et	et	PROPN
ijpds-4639	132	3	al	al	PROPN
ijpds-4639	132	4	.	.	PROPN
ijpds-4639	132	5	leptin	leptin	PROPN
ijpds-4639	132	6	:	:	PUNCT
ijpds-4639	132	7	its	its	PRON
ijpds-4639	132	8	crucial	crucial	ADJ
ijpds-4639	132	9	role	role	NOUN
ijpds-4639	132	10	in	in	ADP
ijpds-4639	132	11	the	the	DET
ijpds-4639	132	12	fight	fight	NOUN
ijpds-4639	132	13	against	against	ADP
ijpds-4639	132	14	obesity	obesity	NOUN
ijpds-4639	132	15	online	online	ADJ
ijpds-4639	132	16	first	first	PROPN
ijpds-4639	132	17	indian	indian	PROPN
ijpds-4639	132	18	j	j	PROPN
ijpds-4639	132	19	pharm	pharm	PROPN
ijpds-4639	132	20	drug	drug	PROPN
ijpds-4639	132	21	studies	study	NOUN
ijpds-4639	132	22	|	|	ADV
ijpds-4639	132	23	4	4	NUM
ijpds-4639	132	24	since	since	SCONJ
ijpds-4639	132	25	it	it	PRON
ijpds-4639	132	26	controls	control	VERB
ijpds-4639	132	27	the	the	DET
ijpds-4639	132	28	release	release	NOUN
ijpds-4639	132	29	of	of	ADP
ijpds-4639	132	30	hypothalamic	hypothalamic	ADJ
ijpds-4639	132	31	neuropeptides	neuropeptide	NOUN
ijpds-4639	132	32	.	.	PUNCT
ijpds-4639	133	1	in	in	ADP
ijpds-4639	133	2	addition	addition	NOUN
ijpds-4639	133	3	to	to	ADP
ijpds-4639	133	4	socs3	socs3	ADJ
ijpds-4639	133	5	,	,	PUNCT
ijpds-4639	133	6	ptp1b	ptp1b	PROPN
ijpds-4639	133	7	is	be	AUX
ijpds-4639	133	8	a	a	DET
ijpds-4639	133	9	negative	negative	ADJ
ijpds-4639	133	10	regulator	regulator	NOUN
ijpds-4639	133	11	of	of	ADP
ijpds-4639	133	12	both	both	CCONJ
ijpds-4639	133	13	leptin	leptin	NOUN
ijpds-4639	133	14	and	and	CCONJ
ijpds-4639	133	15	insulin	insulin	NOUN
ijpds-4639	133	16	signaling	signal	VERB
ijpds-4639	133	17	.	.	PUNCT
ijpds-4639	134	1	leptin	leptin	NOUN
ijpds-4639	134	2	resistance	resistance	NOUN
ijpds-4639	134	3	is	be	AUX
ijpds-4639	134	4	also	also	ADV
ijpds-4639	134	5	associated	associate	VERB
ijpds-4639	134	6	with	with	ADP
ijpds-4639	134	7	a	a	DET
ijpds-4639	134	8	downregulation	downregulation	NOUN
ijpds-4639	134	9	of	of	ADP
ijpds-4639	134	10	positive	positive	ADJ
ijpds-4639	134	11	regulators	regulator	NOUN
ijpds-4639	134	12	of	of	ADP
ijpds-4639	134	13	obrb	obrb	ADJ
ijpds-4639	134	14	signal	signal	PROPN
ijpds-4639	134	15	transduction	transduction	NOUN
ijpds-4639	134	16	.	.	PUNCT
ijpds-4639	135	1	in	in	ADP
ijpds-4639	135	2	particular	particular	ADJ
ijpds-4639	135	3	,	,	PUNCT
ijpds-4639	135	4	the	the	DET
ijpds-4639	135	5	leptin	leptin	NOUN
ijpds-4639	135	6	-	-	PUNCT
ijpds-4639	135	7	induced	induce	VERB
ijpds-4639	135	8	stat3	stat3	NOUN
ijpds-4639	135	9	phosphorylation	phosphorylation	NOUN
ijpds-4639	135	10	is	be	AUX
ijpds-4639	135	11	essential	essential	ADJ
ijpds-4639	135	12	to	to	PART
ijpds-4639	135	13	obtain	obtain	VERB
ijpds-4639	135	14	a	a	DET
ijpds-4639	135	15	clear	clear	ADJ
ijpds-4639	135	16	activation	activation	NOUN
ijpds-4639	135	17	of	of	ADP
ijpds-4639	135	18	hypothalamic	hypothalamic	ADJ
ijpds-4639	135	19	neurons	neuron	NOUN
ijpds-4639	135	20	,	,	PUNCT
ijpds-4639	135	21	releasing	release	VERB
ijpds-4639	135	22	thus	thus	ADV
ijpds-4639	135	23	the	the	DET
ijpds-4639	135	24	anorexigenic	anorexigenic	ADJ
ijpds-4639	135	25	neuropeptides	neuropeptide	NOUN
ijpds-4639	135	26	.	.	PUNCT
ijpds-4639	136	1	impairment	impairment	NOUN
ijpds-4639	136	2	of	of	ADP
ijpds-4639	136	3	mc4r	mc4r	PROPN
ijpds-4639	136	4	downstream	downstream	ADJ
ijpds-4639	136	5	signal	signal	NOUN
ijpds-4639	136	6	transduction	transduction	NOUN
ijpds-4639	136	7	in	in	ADP
ijpds-4639	136	8	neural	neural	ADJ
ijpds-4639	136	9	circuits	circuit	NOUN
ijpds-4639	136	10	:	:	PUNCT
ijpds-4639	136	11	the	the	DET
ijpds-4639	136	12	melanocortin	melanocortin	NOUN
ijpds-4639	136	13	system	system	NOUN
ijpds-4639	136	14	controls	control	VERB
ijpds-4639	136	15	the	the	DET
ijpds-4639	136	16	energy	energy	NOUN
ijpds-4639	136	17	balance	balance	NOUN
ijpds-4639	136	18	,	,	PUNCT
ijpds-4639	136	19	especially	especially	ADV
ijpds-4639	136	20	trough	trough	ADP
ijpds-4639	136	21	the	the	DET
ijpds-4639	136	22	mc4r	mc4r	PROPN
ijpds-4639	136	23	,	,	PUNCT
ijpds-4639	136	24	which	which	PRON
ijpds-4639	136	25	is	be	AUX
ijpds-4639	136	26	mostly	mostly	ADV
ijpds-4639	136	27	expressed	express	VERB
ijpds-4639	136	28	in	in	ADP
ijpds-4639	136	29	the	the	DET
ijpds-4639	136	30	brain	brain	NOUN
ijpds-4639	136	31	.	.	PUNCT
ijpds-4639	137	1	therefore	therefore	ADV
ijpds-4639	137	2	,	,	PUNCT
ijpds-4639	137	3	alterations	alteration	NOUN
ijpds-4639	137	4	in	in	ADP
ijpds-4639	137	5	the	the	DET
ijpds-4639	137	6	mcardependent	mcardependent	NOUN
ijpds-4639	137	7	brain	brain	NOUN
ijpds-4639	137	8	-	-	PUNCT
ijpds-4639	137	9	derived	derive	VERB
ijpds-4639	137	10	neurotrophic	neurotrophic	ADJ
ijpds-4639	137	11	factor	factor	NOUN
ijpds-4639	137	12	(	(	PUNCT
ijpds-4639	137	13	bdnf)/tropomyosin	bdnf)/tropomyosin	NOUN
ijpds-4639	137	14	receptor	receptor	NOUN
ijpds-4639	137	15	kinase	kinase	PROPN
ijpds-4639	137	16	(	(	PUNCT
ijpds-4639	137	17	trk	trk	PROPN
ijpds-4639	137	18	)	)	PUNCT
ijpds-4639	137	19	b	b	NOUN
ijpds-4639	137	20	signalling	signal	VERB
ijpds-4639	137	21	pathway	pathway	NOUN
ijpds-4639	137	22	,	,	PUNCT
ijpds-4639	137	23	in	in	ADP
ijpds-4639	137	24	the	the	DET
ijpds-4639	137	25	ventromedial	ventromedial	ADJ
ijpds-4639	137	26	nucleus	nucleus	NOUN
ijpds-4639	137	27	(	(	PUNCT
ijpds-4639	137	28	vmn	vmn	NOUN
ijpds-4639	137	29	)	)	PUNCT
ijpds-4639	137	30	,	,	PUNCT
ijpds-4639	137	31	can	can	AUX
ijpds-4639	137	32	affect	affect	VERB
ijpds-4639	137	33	leptin	leptin	NOUN
ijpds-4639	137	34	resistance	resistance	NOUN
ijpds-4639	137	35	.	.	PUNCT
ijpds-4639	138	1	as	as	SCONJ
ijpds-4639	138	2	demonstrated	demonstrate	VERB
ijpds-4639	138	3	by	by	ADP
ijpds-4639	138	4	liao	liao	PROPN
ijpds-4639	138	5	et	et	PROPN
ijpds-4639	138	6	al	al	PROPN
ijpds-4639	138	7	.	.	PUNCT
ijpds-4639	139	1	[	[	X
ijpds-4639	139	2	34	34	NUM
ijpds-4639	139	3	]	]	PUNCT
ijpds-4639	139	4	,	,	PUNCT
ijpds-4639	139	5	mice	mouse	NOUN
ijpds-4639	139	6	harbouring	harbour	VERB
ijpds-4639	139	7	a	a	DET
ijpds-4639	139	8	truncated	truncated	ADJ
ijpds-4639	139	9	long	long	ADJ
ijpds-4639	139	10	bdnf	bdnf	NOUN
ijpds-4639	139	11	3	3	NUM
ijpds-4639	139	12	utr	utr	NOUN
ijpds-4639	139	13	develop	develop	VERB
ijpds-4639	139	14	a	a	DET
ijpds-4639	139	15	severe	severe	ADJ
ijpds-4639	139	16	hyperphagia	hyperphagia	NOUN
ijpds-4639	139	17	and	and	CCONJ
ijpds-4639	139	18	a	a	DET
ijpds-4639	139	19	clear	clear	ADJ
ijpds-4639	139	20	obese	obese	ADJ
ijpds-4639	139	21	phenotype	phenotype	NOUN
ijpds-4639	139	22	.	.	PUNCT
ijpds-4639	140	1	in	in	ADP
ijpds-4639	140	2	this	this	DET
ijpds-4639	140	3	genetic	genetic	ADJ
ijpds-4639	140	4	model	model	NOUN
ijpds-4639	140	5	,	,	PUNCT
ijpds-4639	140	6	leptin	leptin	NOUN
ijpds-4639	140	7	is	be	AUX
ijpds-4639	140	8	unable	unable	ADJ
ijpds-4639	140	9	to	to	PART
ijpds-4639	140	10	activate	activate	VERB
ijpds-4639	140	11	hypothalamic	hypothalamic	ADJ
ijpds-4639	140	12	neurons	neuron	NOUN
ijpds-4639	140	13	and	and	CCONJ
ijpds-4639	140	14	reduce	reduce	VERB
ijpds-4639	140	15	food	food	NOUN
ijpds-4639	140	16	intake	intake	NOUN
ijpds-4639	140	17	.	.	PUNCT
ijpds-4639	141	1	role	role	NOUN
ijpds-4639	141	2	of	of	ADP
ijpds-4639	141	3	hypothalamic	hypothalamic	ADJ
ijpds-4639	141	4	er	er	INTJ
ijpds-4639	141	5	stress	stress	NOUN
ijpds-4639	141	6	in	in	ADP
ijpds-4639	141	7	central	central	ADJ
ijpds-4639	141	8	leptin	leptin	NOUN
ijpds-4639	141	9	resistance	resistance	NOUN
ijpds-4639	141	10	:	:	PUNCT
ijpds-4639	141	11	the	the	DET
ijpds-4639	141	12	er	er	INTJ
ijpds-4639	141	13	is	be	AUX
ijpds-4639	141	14	responsible	responsible	ADJ
ijpds-4639	141	15	for	for	ADP
ijpds-4639	141	16	folding	fold	VERB
ijpds-4639	141	17	nascent	nascent	ADJ
ijpds-4639	141	18	proteins	protein	NOUN
ijpds-4639	141	19	and	and	CCONJ
ijpds-4639	141	20	this	this	DET
ijpds-4639	141	21	process	process	NOUN
ijpds-4639	141	22	is	be	AUX
ijpds-4639	141	23	possible	possible	ADJ
ijpds-4639	141	24	until	until	SCONJ
ijpds-4639	141	25	there	there	PRON
ijpds-4639	141	26	is	be	VERB
ijpds-4639	141	27	a	a	DET
ijpds-4639	141	28	perfect	perfect	ADJ
ijpds-4639	141	29	balance	balance	NOUN
ijpds-4639	141	30	between	between	ADP
ijpds-4639	141	31	the	the	DET
ijpds-4639	141	32	er	er	INTJ
ijpds-4639	141	33	capability	capability	NOUN
ijpds-4639	141	34	to	to	PART
ijpds-4639	141	35	fold	fold	VERB
ijpds-4639	141	36	these	these	DET
ijpds-4639	141	37	macromolecules	macromolecule	NOUN
ijpds-4639	141	38	and	and	CCONJ
ijpds-4639	141	39	the	the	DET
ijpds-4639	141	40	amount	amount	NOUN
ijpds-4639	141	41	of	of	ADP
ijpds-4639	141	42	loaded	load	VERB
ijpds-4639	141	43	proteins	protein	NOUN
ijpds-4639	141	44	.	.	PUNCT
ijpds-4639	142	1	as	as	ADV
ijpds-4639	142	2	soon	soon	ADV
ijpds-4639	142	3	as	as	SCONJ
ijpds-4639	142	4	an	an	DET
ijpds-4639	142	5	imbalance	imbalance	NOUN
ijpds-4639	142	6	between	between	ADP
ijpds-4639	142	7	these	these	DET
ijpds-4639	142	8	folding	folding	NOUN
ijpds-4639	142	9	and	and	CCONJ
ijpds-4639	142	10	loading	loading	NOUN
ijpds-4639	142	11	processes	process	NOUN
ijpds-4639	142	12	occurs	occur	VERB
ijpds-4639	142	13	,	,	PUNCT
ijpds-4639	142	14	er	er	INTJ
ijpds-4639	142	15	stress	stress	NOUN
ijpds-4639	142	16	appears	appear	VERB
ijpds-4639	142	17	,	,	PUNCT
ijpds-4639	142	18	leading	lead	VERB
ijpds-4639	142	19	to	to	ADP
ijpds-4639	142	20	the	the	DET
ijpds-4639	142	21	activation	activation	NOUN
ijpds-4639	142	22	of	of	ADP
ijpds-4639	142	23	several	several	ADJ
ijpds-4639	142	24	pathways	pathway	NOUN
ijpds-4639	142	25	(	(	PUNCT
ijpds-4639	142	26	ie	ie	X
ijpds-4639	142	27	.	.	X
ijpds-4639	142	28	unfolded	unfold	VERB
ijpds-4639	142	29	protein	protein	NOUN
ijpds-4639	142	30	response	response	NOUN
ijpds-4639	142	31	(	(	PUNCT
ijpds-4639	142	32	upr	upr	NOUN
ijpds-4639	142	33	)	)	PUNCT
ijpds-4639	142	34	,	,	PUNCT
ijpds-4639	142	35	inositol	inositol	NOUN
ijpds-4639	142	36	-	-	PUNCT
ijpds-4639	142	37	requiring	require	VERB
ijpds-4639	142	38	protein	protein	NOUN
ijpds-4639	142	39	(	(	PUNCT
ijpds-4639	142	40	ire)-1	ire)-1	NOUN
ijpds-4639	142	41	and	and	CCONJ
ijpds-4639	142	42	protein	protein	NOUN
ijpds-4639	142	43	kinase	kinase	PROPN
ijpds-4639	142	44	rna	rna	PROPN
ijpds-4639	142	45	(	(	PUNCT
ijpds-4639	142	46	pkr)-like	pkr)-like	PROPN
ijpds-4639	142	47	kinase	kinase	PROPN
ijpds-4639	142	48	(	(	PUNCT
ijpds-4639	142	49	perk	perk	NOUN
ijpds-4639	142	50	)	)	PUNCT
ijpds-4639	142	51	pathways	pathway	NOUN
ijpds-4639	142	52	)	)	PUNCT
ijpds-4639	142	53	,	,	PUNCT
ijpds-4639	142	54	which	which	PRON
ijpds-4639	142	55	collectively	collectively	ADV
ijpds-4639	142	56	attempt	attempt	VERB
ijpds-4639	142	57	to	to	PART
ijpds-4639	142	58	counteract	counteract	VERB
ijpds-4639	142	59	the	the	DET
ijpds-4639	142	60	er	er	INTJ
ijpds-4639	142	61	stress	stress	NOUN
ijpds-4639	142	62	itself	itself	PRON
ijpds-4639	142	63	,	,	PUNCT
ijpds-4639	142	64	restoring	restore	VERB
ijpds-4639	142	65	the	the	DET
ijpds-4639	142	66	er	er	INTJ
ijpds-4639	142	67	homeostasis	homeostasis	NOUN
ijpds-4639	142	68	.	.	PUNCT
ijpds-4639	143	1	to	to	ADP
ijpds-4639	143	2	date	date	NOUN
ijpds-4639	143	3	,	,	PUNCT
ijpds-4639	143	4	a	a	DET
ijpds-4639	143	5	growing	grow	VERB
ijpds-4639	143	6	body	body	NOUN
ijpds-4639	143	7	of	of	ADP
ijpds-4639	143	8	evidence	evidence	NOUN
ijpds-4639	143	9	has	have	AUX
ijpds-4639	143	10	demonstrated	demonstrate	VERB
ijpds-4639	143	11	the	the	DET
ijpds-4639	143	12	involvement	involvement	NOUN
ijpds-4639	143	13	of	of	ADP
ijpds-4639	143	14	the	the	DET
ijpds-4639	143	15	hypothalamic	hypothalamic	ADJ
ijpds-4639	143	16	er	er	INTJ
ijpds-4639	143	17	stress	stress	NOUN
ijpds-4639	143	18	in	in	ADP
ijpds-4639	143	19	central	central	ADJ
ijpds-4639	143	20	leptin	leptin	NOUN
ijpds-4639	143	21	resistance	resistance	NOUN
ijpds-4639	143	22	and	and	CCONJ
ijpds-4639	143	23	obesity	obesity	NOUN
ijpds-4639	143	24	.	.	PUNCT
ijpds-4639	144	1	consistently	consistently	ADV
ijpds-4639	144	2	,	,	PUNCT
ijpds-4639	144	3	pharmacological	pharmacological	ADJ
ijpds-4639	144	4	approaches	approach	NOUN
ijpds-4639	144	5	,	,	PUNCT
ijpds-4639	144	6	consisting	consist	VERB
ijpds-4639	144	7	in	in	ADP
ijpds-4639	144	8	the	the	DET
ijpds-4639	144	9	central	central	ADJ
ijpds-4639	144	10	administration	administration	NOUN
ijpds-4639	144	11	of	of	ADP
ijpds-4639	144	12	er	er	INTJ
ijpds-4639	144	13	stress	stress	NOUN
ijpds-4639	144	14	inducers	inducer	NOUN
ijpds-4639	144	15	or	or	CCONJ
ijpds-4639	144	16	chemical	chemical	NOUN
ijpds-4639	144	17	er	er	INTJ
ijpds-4639	144	18	chaperons	chaperon	NOUN
ijpds-4639	144	19	,	,	PUNCT
ijpds-4639	144	20	are	be	AUX
ijpds-4639	144	21	able	able	ADJ
ijpds-4639	144	22	to	to	PART
ijpds-4639	144	23	modulate	modulate	VERB
ijpds-4639	144	24	leptin	leptin	NOUN
ijpds-4639	144	25	responsiveness	responsiveness	NOUN
ijpds-4639	144	26	in	in	ADP
ijpds-4639	144	27	an	an	DET
ijpds-4639	144	28	opposite	opposite	ADJ
ijpds-4639	144	29	manner	manner	NOUN
ijpds-4639	144	30	,	,	PUNCT
ijpds-4639	144	31	identifying	identify	VERB
ijpds-4639	144	32	a	a	DET
ijpds-4639	144	33	role	role	NOUN
ijpds-4639	144	34	of	of	ADP
ijpds-4639	144	35	er	er	INTJ
ijpds-4639	144	36	stress	stress	NOUN
ijpds-4639	144	37	in	in	ADP
ijpds-4639	144	38	leptin	leptin	NOUN
ijpds-4639	144	39	resistance	resistance	NOUN
ijpds-4639	145	1	[	[	X
ijpds-4639	145	2	35	35	NUM
ijpds-4639	145	3	]	]	PUNCT
ijpds-4639	145	4	.	.	PUNCT
ijpds-4639	146	1	defective	defective	ADJ
ijpds-4639	146	2	autophagy	autophagy	NOUN
ijpds-4639	146	3	as	as	ADP
ijpds-4639	146	4	a	a	DET
ijpds-4639	146	5	contributor	contributor	NOUN
ijpds-4639	146	6	of	of	ADP
ijpds-4639	146	7	leptin	leptin	NOUN
ijpds-4639	146	8	resistance	resistance	NOUN
ijpds-4639	146	9	:	:	PUNCT
ijpds-4639	146	10	it	it	PRON
ijpds-4639	146	11	has	have	AUX
ijpds-4639	146	12	been	be	AUX
ijpds-4639	146	13	recently	recently	ADV
ijpds-4639	146	14	emphasized	emphasize	VERB
ijpds-4639	146	15	a	a	DET
ijpds-4639	146	16	key	key	ADJ
ijpds-4639	146	17	role	role	NOUN
ijpds-4639	146	18	for	for	ADP
ijpds-4639	146	19	the	the	DET
ijpds-4639	146	20	autophagy	autophagy	NOUN
ijpds-4639	146	21	in	in	ADP
ijpds-4639	146	22	regulating	regulate	VERB
ijpds-4639	146	23	the	the	DET
ijpds-4639	146	24	overall	overall	ADJ
ijpds-4639	146	25	energy	energy	NOUN
ijpds-4639	146	26	balance	balance	NOUN
ijpds-4639	146	27	,	,	PUNCT
ijpds-4639	146	28	since	since	SCONJ
ijpds-4639	146	29	the	the	DET
ijpds-4639	146	30	inhibition	inhibition	NOUN
ijpds-4639	146	31	of	of	ADP
ijpds-4639	146	32	this	this	DET
ijpds-4639	146	33	process	process	NOUN
ijpds-4639	146	34	,	,	PUNCT
ijpds-4639	146	35	by	by	ADP
ijpds-4639	146	36	a	a	DET
ijpds-4639	146	37	neuronspecific	neuronspecific	ADJ
ijpds-4639	146	38	deletion	deletion	NOUN
ijpds-4639	146	39	of	of	ADP
ijpds-4639	146	40	autophagy	autophagy	ADV
ijpds-4639	146	41	related	relate	VERB
ijpds-4639	146	42	protein	protein	NOUN
ijpds-4639	146	43	(	(	PUNCT
ijpds-4639	146	44	atg	atg	PROPN
ijpds-4639	146	45	)	)	PUNCT
ijpds-4639	146	46	7	7	NUM
ijpds-4639	146	47	,	,	PUNCT
ijpds-4639	146	48	can	can	AUX
ijpds-4639	146	49	alter	alter	VERB
ijpds-4639	146	50	the	the	DET
ijpds-4639	146	51	phenotype	phenotype	NOUN
ijpds-4639	146	52	in	in	ADP
ijpds-4639	146	53	mice	mouse	NOUN
ijpds-4639	146	54	.	.	PUNCT
ijpds-4639	147	1	in	in	ADP
ijpds-4639	147	2	particular	particular	ADJ
ijpds-4639	147	3	,	,	PUNCT
ijpds-4639	147	4	mice	mouse	NOUN
ijpds-4639	147	5	show	show	VERB
ijpds-4639	147	6	an	an	DET
ijpds-4639	147	7	obese	obese	ADJ
ijpds-4639	147	8	phenotype	phenotype	NOUN
ijpds-4639	147	9	when	when	SCONJ
ijpds-4639	147	10	this	this	DET
ijpds-4639	147	11	wellknown	wellknown	ADJ
ijpds-4639	147	12	autophagy	autophagy	NOUN
ijpds-4639	147	13	component	component	NOUN
ijpds-4639	147	14	is	be	AUX
ijpds-4639	147	15	selectively	selectively	ADV
ijpds-4639	147	16	knocked	knock	VERB
ijpds-4639	147	17	down	down	ADP
ijpds-4639	147	18	in	in	ADP
ijpds-4639	147	19	pomc	pomc	NOUN
ijpds-4639	147	20	neurons	neuron	NOUN
ijpds-4639	147	21	,	,	PUNCT
ijpds-4639	147	22	probably	probably	ADV
ijpds-4639	147	23	because	because	SCONJ
ijpds-4639	147	24	this	this	DET
ijpds-4639	147	25	deletion	deletion	NOUN
ijpds-4639	147	26	is	be	AUX
ijpds-4639	147	27	associated	associate	VERB
ijpds-4639	147	28	also	also	ADV
ijpds-4639	147	29	with	with	ADP
ijpds-4639	147	30	a	a	DET
ijpds-4639	147	31	reduction	reduction	NOUN
ijpds-4639	147	32	of	of	ADP
ijpds-4639	147	33	leptininduced	leptininduce	VERB
ijpds-4639	147	34	stat3	stat3	NOUN
ijpds-4639	147	35	phosphorylation	phosphorylation	NOUN
ijpds-4639	147	36	;	;	PUNCT
ijpds-4639	147	37	in	in	ADP
ijpds-4639	147	38	agreement	agreement	NOUN
ijpds-4639	147	39	with	with	ADP
ijpds-4639	147	40	these	these	DET
ijpds-4639	147	41	results	result	NOUN
ijpds-4639	147	42	,	,	PUNCT
ijpds-4639	147	43	the	the	DET
ijpds-4639	147	44	deletion	deletion	NOUN
ijpds-4639	147	45	of	of	ADP
ijpds-4639	147	46	this	this	DET
ijpds-4639	147	47	gene	gene	NOUN
ijpds-4639	147	48	in	in	ADP
ijpds-4639	147	49	agrp	agrp	NOUN
ijpds-4639	147	50	neurons	neuron	NOUN
ijpds-4639	147	51	causes	cause	VERB
ijpds-4639	147	52	a	a	DET
ijpds-4639	147	53	reduction	reduction	NOUN
ijpds-4639	147	54	in	in	ADP
ijpds-4639	147	55	fat	fat	ADJ
ijpds-4639	147	56	mass	mass	NOUN
ijpds-4639	147	57	collectively	collectively	ADV
ijpds-4639	147	58	,	,	PUNCT
ijpds-4639	147	59	these	these	DET
ijpds-4639	147	60	data	datum	NOUN
ijpds-4639	147	61	highlight	highlight	VERB
ijpds-4639	147	62	that	that	SCONJ
ijpds-4639	147	63	the	the	DET
ijpds-4639	147	64	hypothalamic	hypothalamic	ADJ
ijpds-4639	147	65	autophagy	autophagy	ADJ
ijpds-4639	147	66	deficiency	deficiency	NOUN
ijpds-4639	147	67	is	be	AUX
ijpds-4639	147	68	involved	involve	VERB
ijpds-4639	147	69	in	in	ADP
ijpds-4639	147	70	leptin	leptin	NOUN
ijpds-4639	147	71	resistance	resistance	NOUN
ijpds-4639	147	72	and	and	CCONJ
ijpds-4639	147	73	obesity	obesity	NOUN
ijpds-4639	148	1	[	[	X
ijpds-4639	148	2	36	36	NUM
ijpds-4639	148	3	]	]	PUNCT
ijpds-4639	148	4	.	.	PUNCT
ijpds-4639	149	1	strategies	strategy	NOUN
ijpds-4639	149	2	to	to	PART
ijpds-4639	149	3	overcome	overcome	VERB
ijpds-4639	149	4	leptin	leptin	NOUN
ijpds-4639	149	5	resistance	resistance	NOUN
ijpds-4639	149	6	:	:	PUNCT
ijpds-4639	149	7	caloric	caloric	NOUN
ijpds-4639	149	8	restriction	restriction	NOUN
ijpds-4639	149	9	and	and	CCONJ
ijpds-4639	149	10	exercise	exercise	NOUN
ijpds-4639	149	11	:	:	PUNCT
ijpds-4639	149	12	caloric	caloric	NOUN
ijpds-4639	149	13	restriction	restriction	NOUN
ijpds-4639	149	14	is	be	AUX
ijpds-4639	149	15	the	the	DET
ijpds-4639	149	16	first	first	ADJ
ijpds-4639	149	17	approach	approach	NOUN
ijpds-4639	149	18	for	for	ADP
ijpds-4639	149	19	the	the	DET
ijpds-4639	149	20	treatment	treatment	NOUN
ijpds-4639	149	21	of	of	ADP
ijpds-4639	149	22	obesity	obesity	NOUN
ijpds-4639	149	23	able	able	ADJ
ijpds-4639	149	24	to	to	PART
ijpds-4639	149	25	reduce	reduce	VERB
ijpds-4639	149	26	circulating	circulate	VERB
ijpds-4639	149	27	leptin	leptin	NOUN
ijpds-4639	149	28	levels	level	NOUN
ijpds-4639	149	29	,	,	PUNCT
ijpds-4639	149	30	as	as	ADP
ijpds-4639	149	31	an	an	DET
ijpds-4639	149	32	alternative	alternative	NOUN
ijpds-4639	149	33	to	to	ADP
ijpds-4639	149	34	pharmacologic	pharmacologic	ADJ
ijpds-4639	149	35	reversal	reversal	NOUN
ijpds-4639	149	36	of	of	ADP
ijpds-4639	149	37	leptin	leptin	NOUN
ijpds-4639	149	38	resistance	resistance	NOUN
ijpds-4639	149	39	.	.	PUNCT
ijpds-4639	150	1	it	it	PRON
ijpds-4639	150	2	has	have	AUX
ijpds-4639	150	3	been	be	AUX
ijpds-4639	150	4	reported	report	VERB
ijpds-4639	150	5	that	that	SCONJ
ijpds-4639	150	6	long	long	ADJ
ijpds-4639	150	7	term	term	NOUN
ijpds-4639	150	8	exercise	exercise	NOUN
ijpds-4639	150	9	,	,	PUNCT
ijpds-4639	150	10	not	not	PART
ijpds-4639	150	11	only	only	ADV
ijpds-4639	150	12	decreased	decrease	VERB
ijpds-4639	150	13	leptin	leptin	NOUN
ijpds-4639	150	14	levels	level	NOUN
ijpds-4639	150	15	,	,	PUNCT
ijpds-4639	150	16	but	but	CCONJ
ijpds-4639	150	17	also	also	ADV
ijpds-4639	150	18	increases	increase	VERB
ijpds-4639	150	19	the	the	DET
ijpds-4639	150	20	activation	activation	NOUN
ijpds-4639	150	21	of	of	ADP
ijpds-4639	150	22	stat3	stat3	NOUN
ijpds-4639	150	23	and	and	CCONJ
ijpds-4639	150	24	ampk	ampk	NOUN
ijpds-4639	150	25	signalling	signal	VERB
ijpds-4639	150	26	pathways	pathway	NOUN
ijpds-4639	150	27	in	in	ADP
ijpds-4639	150	28	the	the	DET
ijpds-4639	150	29	hypothalamic	hypothalamic	ADJ
ijpds-4639	150	30	arcuate	arcuate	NOUN
ijpds-4639	150	31	nucleus	nucleus	PROPN
ijpds-4639	150	32	.	.	PUNCT
ijpds-4639	151	1	prevention	prevention	NOUN
ijpds-4639	151	2	of	of	ADP
ijpds-4639	151	3	leptin	leptin	NOUN
ijpds-4639	151	4	resistance	resistance	NOUN
ijpds-4639	151	5	by	by	ADP
ijpds-4639	151	6	exercise	exercise	NOUN
ijpds-4639	151	7	was	be	AUX
ijpds-4639	151	8	also	also	ADV
ijpds-4639	151	9	demonstrated	demonstrate	VERB
ijpds-4639	151	10	by	by	ADP
ijpds-4639	151	11	zhou	zhou	PROPN
ijpds-4639	152	1	[	[	X
ijpds-4639	152	2	37	37	NUM
ijpds-4639	152	3	]	]	PUNCT
ijpds-4639	152	4	,	,	PUNCT
ijpds-4639	152	5	who	who	PRON
ijpds-4639	152	6	showed	show	VERB
ijpds-4639	152	7	a	a	DET
ijpds-4639	152	8	reduction	reduction	NOUN
ijpds-4639	152	9	in	in	ADP
ijpds-4639	152	10	hypothalamic	hypothalamic	ADJ
ijpds-4639	152	11	socs3	socs3	ADJ
ijpds-4639	152	12	mrna	mrna	PROPN
ijpds-4639	152	13	expression	expression	NOUN
ijpds-4639	152	14	and	and	CCONJ
ijpds-4639	152	15	jak2	jak2	PROPN
ijpds-4639	152	16	/	/	SYM
ijpds-4639	152	17	stat3	stat3	NOUN
ijpds-4639	152	18	signalling	signal	VERB
ijpds-4639	152	19	pathway	pathway	NOUN
ijpds-4639	152	20	in	in	ADP
ijpds-4639	152	21	rats	rat	NOUN
ijpds-4639	152	22	fed	feed	VERB
ijpds-4639	152	23	a	a	DET
ijpds-4639	152	24	high	high	ADJ
ijpds-4639	152	25	fat	fat	ADJ
ijpds-4639	152	26	diet	diet	NOUN
ijpds-4639	152	27	by	by	ADP
ijpds-4639	152	28	exercise	exercise	NOUN
ijpds-4639	152	29	.	.	PUNCT
ijpds-4639	153	1	however	however	ADV
ijpds-4639	153	2	,	,	PUNCT
ijpds-4639	153	3	when	when	SCONJ
ijpds-4639	153	4	exercise	exercise	NOUN
ijpds-4639	153	5	was	be	AUX
ijpds-4639	153	6	combined	combine	VERB
ijpds-4639	153	7	with	with	ADP
ijpds-4639	153	8	caloric	caloric	NOUN
ijpds-4639	153	9	restriction	restriction	NOUN
ijpds-4639	153	10	the	the	DET
ijpds-4639	153	11	effect	effect	NOUN
ijpds-4639	153	12	was	be	AUX
ijpds-4639	153	13	more	more	ADV
ijpds-4639	153	14	evident	evident	ADJ
ijpds-4639	153	15	compared	compare	VERB
ijpds-4639	153	16	to	to	ADP
ijpds-4639	153	17	those	those	PRON
ijpds-4639	153	18	obtained	obtain	VERB
ijpds-4639	153	19	by	by	ADP
ijpds-4639	153	20	exercise	exercise	NOUN
ijpds-4639	153	21	or	or	CCONJ
ijpds-4639	153	22	diet	diet	NOUN
ijpds-4639	153	23	approach	approach	NOUN
ijpds-4639	153	24	alone	alone	ADV
ijpds-4639	153	25	[	[	X
ijpds-4639	153	26	38	38	NUM
ijpds-4639	153	27	]	]	PUNCT
ijpds-4639	153	28	.	.	PUNCT
ijpds-4639	154	1	reversal	reversal	NOUN
ijpds-4639	154	2	of	of	ADP
ijpds-4639	154	3	the	the	DET
ijpds-4639	154	4	inhibition	inhibition	NOUN
ijpds-4639	154	5	of	of	ADP
ijpds-4639	154	6	socs3	socs3	ADJ
ijpds-4639	154	7	and	and	CCONJ
ijpds-4639	154	8	ptp1b	ptp1b	NOUN
ijpds-4639	154	9	:	:	PUNCT
ijpds-4639	154	10	as	as	SCONJ
ijpds-4639	154	11	already	already	ADV
ijpds-4639	154	12	depicted	depict	VERB
ijpds-4639	154	13	,	,	PUNCT
ijpds-4639	154	14	socs3	socs3	ADJ
ijpds-4639	154	15	and	and	CCONJ
ijpds-4639	154	16	ptp1b	ptp1b	NOUN
ijpds-4639	154	17	are	be	AUX
ijpds-4639	154	18	negative	negative	ADJ
ijpds-4639	154	19	regulator	regulator	NOUN
ijpds-4639	154	20	proteins	protein	NOUN
ijpds-4639	154	21	of	of	ADP
ijpds-4639	154	22	leptin	leptin	NOUN
ijpds-4639	154	23	receptor	receptor	NOUN
ijpds-4639	154	24	signalling	signal	VERB
ijpds-4639	154	25	.	.	PUNCT
ijpds-4639	155	1	therefore	therefore	ADV
ijpds-4639	155	2	their	their	PRON
ijpds-4639	155	3	downregulation	downregulation	NOUN
ijpds-4639	155	4	can	can	AUX
ijpds-4639	155	5	be	be	AUX
ijpds-4639	155	6	considered	consider	VERB
ijpds-4639	155	7	a	a	DET
ijpds-4639	155	8	useful	useful	ADJ
ijpds-4639	155	9	approach	approach	NOUN
ijpds-4639	155	10	to	to	PART
ijpds-4639	155	11	revert	revert	VERB
ijpds-4639	155	12	leptin	leptin	NOUN
ijpds-4639	155	13	resistance	resistance	NOUN
ijpds-4639	155	14	[	[	X
ijpds-4639	155	15	39	39	NUM
ijpds-4639	155	16	]	]	PUNCT
ijpds-4639	155	17	.	.	PUNCT
ijpds-4639	156	1	the	the	DET
ijpds-4639	156	2	inhibition	inhibition	NOUN
ijpds-4639	156	3	of	of	ADP
ijpds-4639	156	4	socs3	socs3	ADJ
ijpds-4639	156	5	expression	expression	NOUN
ijpds-4639	156	6	and/or	and/or	CCONJ
ijpds-4639	156	7	activity	activity	NOUN
ijpds-4639	156	8	could	could	AUX
ijpds-4639	156	9	possibly	possibly	ADV
ijpds-4639	156	10	lead	lead	VERB
ijpds-4639	156	11	to	to	ADP
ijpds-4639	156	12	an	an	DET
ijpds-4639	156	13	interruption	interruption	NOUN
ijpds-4639	156	14	of	of	ADP
ijpds-4639	156	15	the	the	DET
ijpds-4639	156	16	negative	negative	ADJ
ijpds-4639	156	17	feedback	feedback	NOUN
ijpds-4639	156	18	loop	loop	NOUN
ijpds-4639	156	19	related	relate	VERB
ijpds-4639	156	20	to	to	PART
ijpds-4639	156	21	leptin	leptin	VERB
ijpds-4639	156	22	resistance	resistance	NOUN
ijpds-4639	156	23	and	and	CCONJ
ijpds-4639	156	24	restore	restore	VERB
ijpds-4639	156	25	leptin	leptin	NOUN
ijpds-4639	156	26	activity	activity	NOUN
ijpds-4639	156	27	.	.	PUNCT
ijpds-4639	157	1	accordingly	accordingly	ADV
ijpds-4639	157	2	,	,	PUNCT
ijpds-4639	157	3	obrb	obrb	VERB
ijpds-4639	157	4	mutation	mutation	NOUN
ijpds-4639	157	5	in	in	ADP
ijpds-4639	157	6	transgenic	transgenic	NOUN
ijpds-4639	157	7	mice	mouse	NOUN
ijpds-4639	157	8	,	,	PUNCT
ijpds-4639	157	9	disabling	disable	VERB
ijpds-4639	157	10	socs3	socs3	ADJ
ijpds-4639	157	11	binding	bind	VERB
ijpds-4639	158	1	[	[	X
ijpds-4639	158	2	40	40	NUM
ijpds-4639	158	3	]	]	PUNCT
ijpds-4639	158	4	.	.	PUNCT
ijpds-4639	159	1	reduced	reduce	VERB
ijpds-4639	159	2	food	food	NOUN
ijpds-4639	159	3	intake	intake	NOUN
ijpds-4639	159	4	,	,	PUNCT
ijpds-4639	159	5	increases	increase	VERB
ijpds-4639	159	6	leptin	leptin	NOUN
ijpds-4639	159	7	sensitivity	sensitivity	NOUN
ijpds-4639	159	8	and	and	CCONJ
ijpds-4639	159	9	reduced	reduce	VERB
ijpds-4639	159	10	weight	weight	NOUN
ijpds-4639	159	11	gain	gain	NOUN
ijpds-4639	159	12	.	.	PUNCT
ijpds-4639	160	1	besides	besides	SCONJ
ijpds-4639	160	2	socs3	socs3	ADJ
ijpds-4639	160	3	,	,	PUNCT
ijpds-4639	160	4	also	also	ADV
ijpds-4639	160	5	ptp1b	ptp1b	VERB
ijpds-4639	160	6	inhibition	inhibition	NOUN
ijpds-4639	160	7	seems	seem	VERB
ijpds-4639	160	8	to	to	PART
ijpds-4639	160	9	be	be	AUX
ijpds-4639	160	10	an	an	DET
ijpds-4639	160	11	attractive	attractive	ADJ
ijpds-4639	160	12	target	target	NOUN
ijpds-4639	160	13	to	to	PART
ijpds-4639	160	14	overcome	overcome	VERB
ijpds-4639	160	15	lentin	lentin	ADJ
ijpds-4639	160	16	resistance	resistance	NOUN
ijpds-4639	161	1	[	[	X
ijpds-4639	161	2	41	41	NUM
ijpds-4639	161	3	]	]	PUNCT
ijpds-4639	161	4	.	.	PUNCT
ijpds-4639	162	1	in	in	ADP
ijpds-4639	162	2	fact	fact	NOUN
ijpds-4639	162	3	deletion	deletion	NOUN
ijpds-4639	162	4	of	of	ADP
ijpds-4639	162	5	ptp1b	ptp1b	NOUN
ijpds-4639	162	6	in	in	ADP
ijpds-4639	162	7	mice	mouse	NOUN
ijpds-4639	162	8	increases	increase	VERB
ijpds-4639	162	9	lentin	lentin	ADJ
ijpds-4639	162	10	sensitivity	sensitivity	NOUN
ijpds-4639	162	11	,	,	PUNCT
ijpds-4639	162	12	reduces	reduce	VERB
ijpds-4639	162	13	body	body	NOUN
ijpds-4639	162	14	weight	weight	NOUN
ijpds-4639	162	15	and	and	CCONJ
ijpds-4639	162	16	increases	increase	VERB
ijpds-4639	162	17	energy	energy	NOUN
ijpds-4639	162	18	expenditure	expenditure	NOUN
ijpds-4639	162	19	.	.	PUNCT
ijpds-4639	163	1	these	these	DET
ijpds-4639	163	2	animals	animal	NOUN
ijpds-4639	163	3	also	also	ADV
ijpds-4639	163	4	showed	show	VERB
ijpds-4639	163	5	an	an	DET
ijpds-4639	163	6	improvement	improvement	NOUN
ijpds-4639	163	7	in	in	ADP
ijpds-4639	163	8	glucose	glucose	NOUN
ijpds-4639	163	9	metabolism	metabolism	NOUN
ijpds-4639	163	10	and	and	CCONJ
ijpds-4639	163	11	uptake	uptake	ADJ
ijpds-4639	163	12	,	,	PUNCT
ijpds-4639	163	13	and	and	CCONJ
ijpds-4639	163	14	they	they	PRON
ijpds-4639	163	15	were	be	AUX
ijpds-4639	163	16	protected	protect	VERB
ijpds-4639	163	17	by	by	ADP
ijpds-4639	163	18	dio	dio	NOUN
ijpds-4639	163	19	.	.	PUNCT
ijpds-4639	164	1	the	the	DET
ijpds-4639	164	2	selective	selective	ADJ
ijpds-4639	164	3	inhibition	inhibition	NOUN
ijpds-4639	164	4	of	of	ADP
ijpds-4639	164	5	ptp1b	ptp1b	NOUN
ijpds-4639	164	6	resulted	result	VERB
ijpds-4639	164	7	in	in	ADP
ijpds-4639	164	8	dampening	dampen	VERB
ijpds-4639	164	9	of	of	ADP
ijpds-4639	164	10	stat3	stat3	NOUN
ijpds-4639	164	11	activation	activation	NOUN
ijpds-4639	164	12	by	by	ADP
ijpds-4639	164	13	leptin	leptin	NOUN
ijpds-4639	164	14	in	in	ADP
ijpds-4639	164	15	hek	hek	PROPN
ijpds-4639	164	16	cells	cell	NOUN
ijpds-4639	164	17	.	.	PUNCT
ijpds-4639	165	1	to	to	ADP
ijpds-4639	165	2	date	date	NOUN
ijpds-4639	165	3	,	,	PUNCT
ijpds-4639	165	4	inhibitors	inhibitor	NOUN
ijpds-4639	165	5	of	of	ADP
ijpds-4639	165	6	ptp1b	ptp1b	NOUN
ijpds-4639	165	7	based	base	VERB
ijpds-4639	165	8	on	on	ADP
ijpds-4639	165	9	capability	capability	NOUN
ijpds-4639	165	10	to	to	PART
ijpds-4639	165	11	bind	bind	VERB
ijpds-4639	165	12	ptpb1	ptpb1	ADJ
ijpds-4639	165	13	active	active	ADJ
ijpds-4639	165	14	site	site	NOUN
ijpds-4639	165	15	(	(	PUNCT
ijpds-4639	165	16	without	without	ADP
ijpds-4639	165	17	hydrolysis	hydrolysis	NOUN
ijpds-4639	165	18	)	)	PUNCT
ijpds-4639	165	19	have	have	AUX
ijpds-4639	165	20	been	be	AUX
ijpds-4639	165	21	designed	design	VERB
ijpds-4639	165	22	.	.	PUNCT
ijpds-4639	166	1	in	in	ADP
ijpds-4639	166	2	particular	particular	ADJ
ijpds-4639	166	3	,	,	PUNCT
ijpds-4639	166	4	thiazolidinedione	thiazolidinedione	ADJ
ijpds-4639	166	5	compounds	compound	NOUN
ijpds-4639	166	6	have	have	AUX
ijpds-4639	166	7	been	be	AUX
ijpds-4639	166	8	shown	show	VERB
ijpds-4639	166	9	to	to	PART
ijpds-4639	166	10	exert	exert	VERB
ijpds-4639	166	11	anti	anti	ADJ
ijpds-4639	166	12	obesity	obesity	NOUN
ijpds-4639	166	13	effects	effect	NOUN
ijpds-4639	166	14	as	as	ADP
ijpds-4639	166	15	ptp1b	ptp1b	NOUN
ijpds-4639	166	16	inhibitors	inhibitor	NOUN
ijpds-4639	166	17	and	and	CCONJ
ijpds-4639	166	18	ppar	ppar	NOUN
ijpds-4639	166	19	-	-	PUNCT
ijpds-4639	166	20	a	a	DET
ijpds-4639	166	21	activators	activator	NOUN
ijpds-4639	166	22	,	,	PUNCT
ijpds-4639	166	23	ameliorating	ameliorate	VERB
ijpds-4639	166	24	blood	blood	NOUN
ijpds-4639	166	25	lipid	lipid	NOUN
ijpds-4639	166	26	profile	profile	NOUN
ijpds-4639	166	27	in	in	ADP
ijpds-4639	166	28	mice	mouse	NOUN
ijpds-4639	166	29	on	on	ADP
ijpds-4639	166	30	high	high	ADJ
ijpds-4639	166	31	fat	fat	ADJ
ijpds-4639	166	32	diet	diet	NOUN
ijpds-4639	167	1	[	[	X
ijpds-4639	167	2	42	42	NUM
ijpds-4639	167	3	]	]	PUNCT
ijpds-4639	167	4	.	.	PUNCT
ijpds-4639	168	1	pomc	pomc	PROPN
ijpds-4639	168	2	neuron	neuron	PROPN
ijpds-4639	168	3	activation	activation	NOUN
ijpds-4639	168	4	:	:	PUNCT
ijpds-4639	168	5	last	last	ADJ
ijpds-4639	168	6	molecular	molecular	ADJ
ijpds-4639	168	7	targets	target	NOUN
ijpds-4639	168	8	of	of	ADP
ijpds-4639	168	9	leptin	leptin	NOUN
ijpds-4639	168	10	effect	effect	NOUN
ijpds-4639	168	11	on	on	ADP
ijpds-4639	168	12	energy	energy	NOUN
ijpds-4639	168	13	balance	balance	NOUN
ijpds-4639	168	14	are	be	AUX
ijpds-4639	168	15	pom	pom	NOUN
ijpds-4639	168	16	neurons	neuron	NOUN
ijpds-4639	168	17	,	,	PUNCT
ijpds-4639	168	18	therefore	therefore	ADV
ijpds-4639	168	19	their	their	PRON
ijpds-4639	168	20	activation	activation	NOUN
ijpds-4639	168	21	seems	seem	VERB
ijpds-4639	168	22	another	another	DET
ijpds-4639	168	23	attractive	attractive	ADJ
ijpds-4639	168	24	strategy	strategy	NOUN
ijpds-4639	168	25	to	to	PART
ijpds-4639	168	26	overcome	overcome	VERB
ijpds-4639	168	27	leptin	leptin	NOUN
ijpds-4639	168	28	receptor	receptor	NOUN
ijpds-4639	168	29	signal	signal	NOUN
ijpds-4639	168	30	to	to	PART
ijpds-4639	168	31	induce	induce	VERB
ijpds-4639	168	32	a	a	DET
ijpds-4639	168	33	-	-	PUNCT
ijpds-4639	168	34	msh	msh	NOUN
ijpds-4639	168	35	-	-	PUNCT
ijpds-4639	168	36	mediated	mediate	VERB
ijpds-4639	168	37	suppression	suppression	NOUN
ijpds-4639	168	38	of	of	ADP
ijpds-4639	168	39	food	food	NOUN
ijpds-4639	168	40	intake	intake	NOUN
ijpds-4639	168	41	and	and	CCONJ
ijpds-4639	168	42	weight	weight	NOUN
ijpds-4639	168	43	gain	gain	NOUN
ijpds-4639	168	44	together	together	ADV
ijpds-4639	168	45	with	with	ADP
ijpds-4639	168	46	an	an	DET
ijpds-4639	168	47	increase	increase	NOUN
ijpds-4639	168	48	in	in	ADP
ijpds-4639	168	49	energy	energy	NOUN
ijpds-4639	168	50	expenditure	expenditure	NOUN
ijpds-4639	168	51	[	[	X
ijpds-4639	168	52	43	43	NUM
ijpds-4639	168	53	]	]	PUNCT
ijpds-4639	168	54	.	.	PUNCT
ijpds-4639	169	1	increase	increase	VERB
ijpds-4639	169	2	in	in	ADP
ijpds-4639	169	3	leptin	leptin	NOUN
ijpds-4639	169	4	receptor	receptor	NOUN
ijpds-4639	169	5	expression	expression	NOUN
ijpds-4639	169	6	and	and	CCONJ
ijpds-4639	169	7	cell	cell	NOUN
ijpds-4639	169	8	surface	surface	NOUN
ijpds-4639	169	9	localization	localization	NOUN
ijpds-4639	169	10	:	:	PUNCT
ijpds-4639	169	11	an	an	DET
ijpds-4639	169	12	increase	increase	NOUN
ijpds-4639	169	13	in	in	ADP
ijpds-4639	169	14	obr	obr	NOUN
ijpds-4639	169	15	expression	expression	NOUN
ijpds-4639	169	16	and	and	CCONJ
ijpds-4639	169	17	its	its	PRON
ijpds-4639	169	18	localization	localization	NOUN
ijpds-4639	169	19	at	at	ADP
ijpds-4639	169	20	the	the	DET
ijpds-4639	169	21	cell	cell	NOUN
ijpds-4639	169	22	surface	surface	NOUN
ijpds-4639	169	23	are	be	AUX
ijpds-4639	169	24	key	key	ADJ
ijpds-4639	169	25	determinants	determinant	NOUN
ijpds-4639	169	26	for	for	ADP
ijpds-4639	169	27	cell	cell	NOUN
ijpds-4639	169	28	sensitivity	sensitivity	NOUN
ijpds-4639	169	29	to	to	PART
ijpds-4639	169	30	leptin	leptin	VERB
ijpds-4639	169	31	[	[	X
ijpds-4639	169	32	44	44	NUM
ijpds-4639	169	33	]	]	PUNCT
ijpds-4639	169	34	.	.	PUNCT
ijpds-4639	170	1	we	we	PRON
ijpds-4639	170	2	demonstrated	demonstrate	VERB
ijpds-4639	170	3	that	that	SCONJ
ijpds-4639	170	4	in	in	ADP
ijpds-4639	170	5	leptin	leptin	NOUN
ijpds-4639	170	6	resistant	resistant	ADJ
ijpds-4639	170	7	ovariectomized	ovariectomize	VERB
ijpds-4639	170	8	obese	obese	ADJ
ijpds-4639	170	9	rats	rat	NOUN
ijpds-4639	170	10	,	,	PUNCT
ijpds-4639	170	11	estradiol	estradiol	PROPN
ijpds-4639	170	12	replacement	replacement	NOUN
ijpds-4639	170	13	therapy	therapy	NOUN
ijpds-4639	170	14	or	or	CCONJ
ijpds-4639	170	15	long	long	ADJ
ijpds-4639	170	16	term	term	NOUN
ijpds-4639	170	17	raloxifene	raloxifene	NOUN
ijpds-4639	170	18	treatment	treatment	NOUN
ijpds-4639	170	19	,	,	PUNCT
ijpds-4639	170	20	reduced	reduce	VERB
ijpds-4639	170	21	leptin	leptin	NOUN
ijpds-4639	170	22	levels	level	NOUN
ijpds-4639	170	23	and	and	CCONJ
ijpds-4639	170	24	body	body	NOUN
ijpds-4639	170	25	weight	weight	NOUN
ijpds-4639	170	26	and	and	CCONJ
ijpds-4639	170	27	restored	restore	VERB
ijpds-4639	170	28	leptin	leptin	NOUN
ijpds-4639	170	29	receptor	receptor	NOUN
ijpds-4639	170	30	expression	expression	NOUN
ijpds-4639	170	31	both	both	CCONJ
ijpds-4639	170	32	in	in	ADP
ijpds-4639	170	33	adipose	adipose	ADJ
ijpds-4639	170	34	tissue	tissue	NOUN
ijpds-4639	170	35	and	and	CCONJ
ijpds-4639	170	36	hypothalamus	hypothalamus	NOUN
ijpds-4639	171	1	[	[	X
ijpds-4639	171	2	45	45	NUM
ijpds-4639	171	3	]	]	PUNCT
ijpds-4639	171	4	.	.	PUNCT
ijpds-4639	172	1	unfortunately	unfortunately	ADV
ijpds-4639	172	2	,	,	PUNCT
ijpds-4639	172	3	singha	singha	PROPN
ijpds-4639	172	4	et	et	PROPN
ijpds-4639	172	5	al	al	PROPN
ijpds-4639	172	6	.	.	PROPN
ijpds-4639	172	7	leptin	leptin	PROPN
ijpds-4639	172	8	:	:	PUNCT
ijpds-4639	172	9	its	its	PRON
ijpds-4639	172	10	crucial	crucial	ADJ
ijpds-4639	172	11	role	role	NOUN
ijpds-4639	172	12	in	in	ADP
ijpds-4639	172	13	the	the	DET
ijpds-4639	172	14	fight	fight	NOUN
ijpds-4639	172	15	against	against	ADP
ijpds-4639	172	16	obesity	obesity	NOUN
ijpds-4639	172	17	online	online	ADJ
ijpds-4639	172	18	first	first	PROPN
ijpds-4639	172	19	indian	indian	PROPN
ijpds-4639	172	20	j	j	PROPN
ijpds-4639	172	21	pharm	pharm	PROPN
ijpds-4639	172	22	drug	drug	PROPN
ijpds-4639	172	23	studies	study	NOUN
ijpds-4639	172	24	|	|	ADV
ijpds-4639	172	25	5	5	NUM
ijpds-4639	172	26	differently	differently	ADV
ijpds-4639	172	27	from	from	ADP
ijpds-4639	172	28	rodent	rodent	ADJ
ijpds-4639	172	29	studies	study	NOUN
ijpds-4639	172	30	,	,	PUNCT
ijpds-4639	172	31	a	a	DET
ijpds-4639	172	32	recent	recent	ADJ
ijpds-4639	172	33	review	review	NOUN
ijpds-4639	172	34	of	of	ADP
ijpds-4639	172	35	the	the	DET
ijpds-4639	172	36	literature	literature	NOUN
ijpds-4639	172	37	regarding	regard	VERB
ijpds-4639	172	38	estrogen	estrogen	NOUN
ijpds-4639	172	39	effect	effect	NOUN
ijpds-4639	172	40	on	on	ADP
ijpds-4639	172	41	leptin	leptin	NOUN
ijpds-4639	172	42	levels	level	NOUN
ijpds-4639	172	43	in	in	ADP
ijpds-4639	172	44	postmenopausal	postmenopausal	ADJ
ijpds-4639	172	45	women	woman	NOUN
ijpds-4639	172	46	,	,	PUNCT
ijpds-4639	172	47	did	do	AUX
ijpds-4639	172	48	not	not	PART
ijpds-4639	172	49	show	show	VERB
ijpds-4639	172	50	evident	evident	ADJ
ijpds-4639	172	51	beneficial	beneficial	ADJ
ijpds-4639	172	52	effects	effect	NOUN
ijpds-4639	172	53	by	by	ADP
ijpds-4639	172	54	hormonal	hormonal	ADJ
ijpds-4639	172	55	intervention	intervention	NOUN
ijpds-4639	172	56	in	in	ADP
ijpds-4639	172	57	modulating	modulate	VERB
ijpds-4639	172	58	leptin	leptin	NOUN
ijpds-4639	172	59	levels	level	NOUN
ijpds-4639	172	60	and	and	CCONJ
ijpds-4639	172	61	attenuating	attenuate	VERB
ijpds-4639	172	62	weight	weight	NOUN
ijpds-4639	172	63	gain	gain	NOUN
ijpds-4639	172	64	.	.	PUNCT
ijpds-4639	173	1	therefore	therefore	ADV
ijpds-4639	173	2	,	,	PUNCT
ijpds-4639	173	3	the	the	DET
ijpds-4639	173	4	authors	author	NOUN
ijpds-4639	173	5	discourage	discourage	VERB
ijpds-4639	173	6	the	the	DET
ijpds-4639	173	7	hormonal	hormonal	ADJ
ijpds-4639	173	8	intervention	intervention	NOUN
ijpds-4639	173	9	in	in	ADP
ijpds-4639	173	10	relation	relation	NOUN
ijpds-4639	173	11	to	to	ADP
ijpds-4639	173	12	cardiovascular	cardiovascular	ADJ
ijpds-4639	173	13	and	and	CCONJ
ijpds-4639	173	14	neoplastic	neoplastic	ADJ
ijpds-4639	173	15	risk	risk	NOUN
ijpds-4639	173	16	associated	associate	VERB
ijpds-4639	173	17	with	with	ADP
ijpds-4639	173	18	the	the	DET
ijpds-4639	173	19	replacement	replacement	NOUN
ijpds-4639	173	20	therapy	therapy	NOUN
ijpds-4639	173	21	[	[	X
ijpds-4639	173	22	46	46	NUM
ijpds-4639	173	23	]	]	PUNCT
ijpds-4639	173	24	.	.	PUNCT
ijpds-4639	174	1	previously	previously	ADV
ijpds-4639	174	2	,	,	PUNCT
ijpds-4639	174	3	clinical	clinical	ADJ
ijpds-4639	174	4	studies	study	NOUN
ijpds-4639	174	5	showed	show	VERB
ijpds-4639	174	6	an	an	DET
ijpds-4639	174	7	increase	increase	NOUN
ijpds-4639	174	8	in	in	ADP
ijpds-4639	174	9	leptin	leptin	NOUN
ijpds-4639	174	10	levels	level	NOUN
ijpds-4639	174	11	and	and	CCONJ
ijpds-4639	174	12	body	body	NOUN
ijpds-4639	174	13	fat	fat	ADJ
ijpds-4639	174	14	content	content	NOUN
ijpds-4639	174	15	in	in	ADP
ijpds-4639	174	16	other	other	ADJ
ijpds-4639	174	17	studies	study	NOUN
ijpds-4639	174	18	reported	report	VERB
ijpds-4639	174	19	an	an	DET
ijpds-4639	174	20	increase	increase	NOUN
ijpds-4639	174	21	in	in	ADP
ijpds-4639	174	22	leptin	leptin	NOUN
ijpds-4639	174	23	levels	level	NOUN
ijpds-4639	174	24	in	in	ADP
ijpds-4639	174	25	treated	treat	VERB
ijpds-4639	174	26	woman	woman	NOUN
ijpds-4639	174	27	,	,	PUNCT
ijpds-4639	174	28	not	not	PART
ijpds-4639	174	29	related	relate	VERB
ijpds-4639	174	30	to	to	PART
ijpds-4639	174	31	change	change	VERB
ijpds-4639	174	32	in	in	ADP
ijpds-4639	174	33	fat	fat	ADJ
ijpds-4639	174	34	mass	mass	PROPN
ijpds-4639	174	35	.	.	PUNCT
ijpds-4639	175	1	it	it	PRON
ijpds-4639	175	2	has	have	AUX
ijpds-4639	175	3	also	also	ADV
ijpds-4639	175	4	been	be	AUX
ijpds-4639	175	5	shown	show	VERB
ijpds-4639	175	6	that	that	SCONJ
ijpds-4639	175	7	metformin	metformin	NOUN
ijpds-4639	175	8	,	,	PUNCT
ijpds-4639	175	9	acting	act	VERB
ijpds-4639	175	10	at	at	ADP
ijpds-4639	175	11	obrb	obrb	ADJ
ijpds-4639	175	12	hypothalamic	hypothalamic	ADJ
ijpds-4639	175	13	gene	gene	NOUN
ijpds-4639	175	14	level	level	NOUN
ijpds-4639	175	15	,	,	PUNCT
ijpds-4639	175	16	is	be	AUX
ijpds-4639	175	17	able	able	ADJ
ijpds-4639	175	18	to	to	PART
ijpds-4639	175	19	increase	increase	VERB
ijpds-4639	175	20	receptor	receptor	NOUN
ijpds-4639	175	21	expression	expression	NOUN
ijpds-4639	175	22	and	and	CCONJ
ijpds-4639	175	23	leptin	leptin	NOUN
ijpds-4639	175	24	sensitivity	sensitivity	NOUN
ijpds-4639	175	25	,	,	PUNCT
ijpds-4639	175	26	and	and	CCONJ
ijpds-4639	175	27	exert	exert	VERB
ijpds-4639	175	28	an	an	DET
ijpds-4639	175	29	anorectic	anorectic	ADJ
ijpds-4639	175	30	effect	effect	NOUN
ijpds-4639	175	31	.	.	PUNCT
ijpds-4639	176	1	moreover	moreover	ADV
ijpds-4639	176	2	,	,	PUNCT
ijpds-4639	176	3	the	the	DET
ijpds-4639	176	4	inverse	inverse	ADJ
ijpds-4639	176	5	agonist	agonist	NOUN
ijpds-4639	176	6	of	of	ADP
ijpds-4639	176	7	cannabinoid	cannabinoid	NOUN
ijpds-4639	176	8	receptor	receptor	NOUN
ijpds-4639	176	9	1	1	NUM
ijpds-4639	176	10	,	,	PUNCT
ijpds-4639	176	11	jd5037,can	jd5037,can	NOUN
ijpds-4639	176	12	overcome	overcome	VERB
ijpds-4639	176	13	leptin	leptin	NOUN
ijpds-4639	176	14	resistance	resistance	NOUN
ijpds-4639	176	15	and	and	CCONJ
ijpds-4639	176	16	reduce	reduce	VERB
ijpds-4639	176	17	weight	weight	NOUN
ijpds-4639	176	18	gain	gain	NOUN
ijpds-4639	176	19	[	[	X
ijpds-4639	176	20	47	47	NUM
ijpds-4639	176	21	]	]	PUNCT
ijpds-4639	176	22	.	.	PUNCT
ijpds-4639	177	1	treatment	treatment	NOUN
ijpds-4639	177	2	of	of	ADP
ijpds-4639	177	3	obesity	obesity	NOUN
ijpds-4639	177	4	based	base	VERB
ijpds-4639	177	5	on	on	ADP
ijpds-4639	177	6	leptin	leptin	NOUN
ijpds-4639	177	7	:	:	PUNCT
ijpds-4639	177	8	leptin	leptin	NOUN
ijpds-4639	177	9	analogous	analogous	NOUN
ijpds-4639	177	10	:	:	PUNCT
ijpds-4639	177	11	metreleptin	metreleptin	PROPN
ijpds-4639	177	12	is	be	AUX
ijpds-4639	177	13	a	a	DET
ijpds-4639	177	14	once	once	ADV
ijpds-4639	177	15	daily	daily	ADJ
ijpds-4639	177	16	subcutaneously	subcutaneously	ADV
ijpds-4639	177	17	administered	administer	VERB
ijpds-4639	177	18	leptin	leptin	NOUN
ijpds-4639	177	19	analogue	analogue	NOUN
ijpds-4639	177	20	approved	approve	VERB
ijpds-4639	177	21	by	by	ADP
ijpds-4639	177	22	the	the	DET
ijpds-4639	177	23	fda	fda	PROPN
ijpds-4639	177	24	in	in	ADP
ijpds-4639	177	25	2014	2014	NUM
ijpds-4639	177	26	for	for	ADP
ijpds-4639	177	27	use	use	NOUN
ijpds-4639	177	28	in	in	ADP
ijpds-4639	177	29	people	people	NOUN
ijpds-4639	177	30	with	with	ADP
ijpds-4639	177	31	leptin	leptin	NOUN
ijpds-4639	177	32	deficiency	deficiency	NOUN
ijpds-4639	177	33	or	or	CCONJ
ijpds-4639	177	34	congenital	congenital	ADJ
ijpds-4639	177	35	/	/	SYM
ijpds-4639	177	36	acquired	acquire	VERB
ijpds-4639	177	37	lipodystrophy	lipodystrophy	NOUN
ijpds-4639	177	38	,	,	PUNCT
ijpds-4639	177	39	with	with	ADP
ijpds-4639	177	40	good	good	ADJ
ijpds-4639	177	41	clinical	clinical	ADJ
ijpds-4639	177	42	results	result	NOUN
ijpds-4639	177	43	in	in	ADP
ijpds-4639	177	44	these	these	DET
ijpds-4639	177	45	conditions	condition	NOUN
ijpds-4639	177	46	.	.	PUNCT
ijpds-4639	178	1	whilst	whilst	SCONJ
ijpds-4639	178	2	metreleptin	metreleptin	NOUN
ijpds-4639	178	3	monotherapy	monotherapy	NOUN
ijpds-4639	178	4	supports	support	VERB
ijpds-4639	178	5	weight	weight	NOUN
ijpds-4639	178	6	loss	loss	NOUN
ijpds-4639	178	7	in	in	ADP
ijpds-4639	178	8	obese	obese	ADJ
ijpds-4639	178	9	individuals	individual	NOUN
ijpds-4639	178	10	,	,	PUNCT
ijpds-4639	178	11	it	it	PRON
ijpds-4639	178	12	is	be	AUX
ijpds-4639	178	13	not	not	PART
ijpds-4639	178	14	clinically	clinically	ADV
ijpds-4639	178	15	meaningful	meaningful	ADJ
ijpds-4639	178	16	with	with	ADP
ijpds-4639	178	17	a	a	DET
ijpds-4639	178	18	mean	mean	ADJ
ijpds-4639	178	19	1.5	1.5	NUM
ijpds-4639	178	20	kg	kg	NOUN
ijpds-4639	178	21	additional	additional	ADJ
ijpds-4639	178	22	weight	weight	NOUN
ijpds-4639	178	23	loss	loss	NOUN
ijpds-4639	178	24	over	over	ADP
ijpds-4639	178	25	24	24	NUM
ijpds-4639	178	26	weeks	week	NOUN
ijpds-4639	178	27	noted	note	VERB
ijpds-4639	178	28	in	in	ADP
ijpds-4639	178	29	a	a	DET
ijpds-4639	178	30	previous	previous	ADJ
ijpds-4639	178	31	trial	trial	NOUN
ijpds-4639	178	32	[	[	X
ijpds-4639	178	33	48	48	NUM
ijpds-4639	178	34	]	]	PUNCT
ijpds-4639	178	35	.	.	PUNCT
ijpds-4639	179	1	to	to	PART
ijpds-4639	179	2	enhance	enhance	VERB
ijpds-4639	179	3	the	the	DET
ijpds-4639	179	4	effect	effect	NOUN
ijpds-4639	179	5	of	of	ADP
ijpds-4639	179	6	leptin	leptin	NOUN
ijpds-4639	179	7	analogues	analogue	NOUN
ijpds-4639	179	8	,	,	PUNCT
ijpds-4639	179	9	amylin	amylin	NOUN
ijpds-4639	179	10	mimetics	mimetic	NOUN
ijpds-4639	179	11	such	such	ADJ
ijpds-4639	179	12	as	as	ADP
ijpds-4639	179	13	pramlintide	pramlintide	NOUN
ijpds-4639	179	14	have	have	AUX
ijpds-4639	179	15	been	be	AUX
ijpds-4639	179	16	used	use	VERB
ijpds-4639	179	17	in	in	ADP
ijpds-4639	179	18	combination	combination	NOUN
ijpds-4639	179	19	with	with	ADP
ijpds-4639	179	20	metreleptin	metreleptin	NOUN
ijpds-4639	179	21	.	.	PUNCT
ijpds-4639	180	1	one	one	NUM
ijpds-4639	180	2	study	study	NOUN
ijpds-4639	180	3	found	find	VERB
ijpds-4639	180	4	that	that	SCONJ
ijpds-4639	180	5	use	use	NOUN
ijpds-4639	180	6	of	of	ADP
ijpds-4639	180	7	the	the	DET
ijpds-4639	180	8	pramlintide	pramlintide	NOUN
ijpds-4639	180	9	/	/	SYM
ijpds-4639	180	10	metreleptin	metreleptin	NOUN
ijpds-4639	180	11	combination	combination	NOUN
ijpds-4639	180	12	resulted	result	VERB
ijpds-4639	180	13	in	in	ADP
ijpds-4639	180	14	11.5	11.5	NUM
ijpds-4639	180	15	kg	kg	NOUN
ijpds-4639	180	16	weight	weight	NOUN
ijpds-4639	180	17	loss	loss	NOUN
ijpds-4639	180	18	over	over	ADP
ijpds-4639	180	19	20	20	NUM
ijpds-4639	180	20	weeks	week	NOUN
ijpds-4639	180	21	compared	compare	VERB
ijpds-4639	180	22	with	with	ADP
ijpds-4639	180	23	7.4	7.4	NUM
ijpds-4639	180	24	kg	kg	NOUN
ijpds-4639	180	25	and	and	CCONJ
ijpds-4639	180	26	7.9	7.9	NUM
ijpds-4639	180	27	kg	kg	NOUN
ijpds-4639	180	28	weight	weight	NOUN
ijpds-4639	180	29	loss	loss	NOUN
ijpds-4639	180	30	respectively	respectively	ADV
ijpds-4639	180	31	in	in	ADP
ijpds-4639	180	32	participants	participant	NOUN
ijpds-4639	180	33	receiving	receive	VERB
ijpds-4639	180	34	either	either	CCONJ
ijpds-4639	180	35	metreleptin	metreleptin	NOUN
ijpds-4639	180	36	or	or	CCONJ
ijpds-4639	180	37	pramlintide	pramlintide	ADJ
ijpds-4639	180	38	monotherapy	monotherapy	NOUN
ijpds-4639	180	39	.	.	PUNCT
ijpds-4639	181	1	unfortunately	unfortunately	ADV
ijpds-4639	181	2	,	,	PUNCT
ijpds-4639	181	3	the	the	DET
ijpds-4639	181	4	development	development	NOUN
ijpds-4639	181	5	of	of	ADP
ijpds-4639	181	6	the	the	DET
ijpds-4639	181	7	combination	combination	NOUN
ijpds-4639	181	8	therapy	therapy	NOUN
ijpds-4639	181	9	was	be	AUX
ijpds-4639	181	10	discontinued	discontinue	VERB
ijpds-4639	181	11	in	in	ADP
ijpds-4639	181	12	2011	2011	NUM
ijpds-4639	181	13	following	follow	VERB
ijpds-4639	181	14	commercial	commercial	ADJ
ijpds-4639	181	15	reassessment	reassessment	NOUN
ijpds-4639	181	16	[	[	X
ijpds-4639	181	17	49	49	NUM
ijpds-4639	181	18	]	]	PUNCT
ijpds-4639	181	19	.	.	PUNCT
ijpds-4639	182	1	phentermine	phentermine	NOUN
ijpds-4639	182	2	and	and	CCONJ
ijpds-4639	182	3	topiramate	topiramate	ADJ
ijpds-4639	182	4	combination	combination	NOUN
ijpds-4639	182	5	therapy	therapy	NOUN
ijpds-4639	182	6	:	:	PUNCT
ijpds-4639	182	7	phentermine	phentermine	NOUN
ijpds-4639	182	8	plus	plus	CCONJ
ijpds-4639	182	9	topiramate	topiramate	ADJ
ijpds-4639	182	10	food	food	NOUN
ijpds-4639	182	11	intake	intake	NOUN
ijpds-4639	182	12	may	may	AUX
ijpds-4639	182	13	be	be	AUX
ijpds-4639	182	14	due	due	ADJ
ijpds-4639	182	15	to	to	ADP
ijpds-4639	182	16	an	an	DET
ijpds-4639	182	17	increase	increase	NOUN
ijpds-4639	182	18	in	in	ADP
ijpds-4639	182	19	hypothalamic	hypothalamic	ADJ
ijpds-4639	182	20	crh	crh	PROPN
ijpds-4639	182	21	,	,	PUNCT
ijpds-4639	182	22	which	which	PRON
ijpds-4639	182	23	is	be	AUX
ijpds-4639	182	24	an	an	DET
ijpds-4639	182	25	anorexigenic	anorexigenic	ADJ
ijpds-4639	182	26	neuropeptide	neuropeptide	NOUN
ijpds-4639	182	27	[	[	X
ijpds-4639	182	28	50	50	NUM
ijpds-4639	182	29	]	]	PUNCT
ijpds-4639	182	30	.	.	PUNCT
ijpds-4639	183	1	furthermore	furthermore	ADV
ijpds-4639	183	2	,	,	PUNCT
ijpds-4639	183	3	tpm	tpm	PROPN
ijpds-4639	183	4	seems	seem	VERB
ijpds-4639	183	5	to	to	PART
ijpds-4639	183	6	reduce	reduce	VERB
ijpds-4639	183	7	energy	energy	NOUN
ijpds-4639	183	8	deposition	deposition	NOUN
ijpds-4639	183	9	even	even	ADV
ijpds-4639	183	10	in	in	ADP
ijpds-4639	183	11	the	the	DET
ijpds-4639	183	12	absence	absence	NOUN
ijpds-4639	183	13	of	of	ADP
ijpds-4639	183	14	changes	change	NOUN
ijpds-4639	183	15	in	in	ADP
ijpds-4639	183	16	food	food	NOUN
ijpds-4639	183	17	intake	intake	NOUN
ijpds-4639	183	18	,	,	PUNCT
ijpds-4639	183	19	suggesting	suggest	VERB
ijpds-4639	183	20	a	a	DET
ijpds-4639	183	21	role	role	NOUN
ijpds-4639	183	22	for	for	ADP
ijpds-4639	183	23	tpm	tpm	PROPN
ijpds-4639	183	24	in	in	ADP
ijpds-4639	183	25	increasing	increase	VERB
ijpds-4639	183	26	energy	energy	NOUN
ijpds-4639	183	27	expenditure	expenditure	NOUN
ijpds-4639	183	28	.	.	PUNCT
ijpds-4639	184	1	nonetheless	nonetheless	ADV
ijpds-4639	184	2	,	,	PUNCT
ijpds-4639	184	3	(	(	PUNCT
ijpds-4639	184	4	tpm	tpm	NOUN
ijpds-4639	184	5	)	)	PUNCT
ijpds-4639	184	6	in	in	ADP
ijpds-4639	184	7	combination	combination	NOUN
ijpds-4639	184	8	markedly	markedly	ADV
ijpds-4639	184	9	decreased	decrease	VERB
ijpds-4639	184	10	body	body	NOUN
ijpds-4639	184	11	weight	weight	NOUN
ijpds-4639	184	12	in	in	ADP
ijpds-4639	184	13	overweight	overweight	ADJ
ijpds-4639	184	14	and	and	CCONJ
ijpds-4639	184	15	obese	obese	ADJ
ijpds-4639	184	16	patients	patient	NOUN
ijpds-4639	184	17	and	and	CCONJ
ijpds-4639	184	18	the	the	DET
ijpds-4639	184	19	us	us	PROPN
ijpds-4639	184	20	.	.	PUNCT
ijpds-4639	185	1	food	food	NOUN
ijpds-4639	185	2	and	and	CCONJ
ijpds-4639	185	3	drug	drug	PROPN
ijpds-4639	185	4	administration	administration	NOUN
ijpds-4639	185	5	just	just	ADV
ijpds-4639	185	6	recommended	recommend	VERB
ijpds-4639	185	7	this	this	DET
ijpds-4639	185	8	drug	drug	NOUN
ijpds-4639	185	9	to	to	PART
ijpds-4639	185	10	be	be	AUX
ijpds-4639	185	11	approved	approve	VERB
ijpds-4639	185	12	to	to	PART
ijpds-4639	185	13	treat	treat	VERB
ijpds-4639	185	14	obesity	obesity	NOUN
ijpds-4639	185	15	tpm	tpm	PROPN
ijpds-4639	185	16	treatment	treatment	NOUN
ijpds-4639	185	17	has	have	AUX
ijpds-4639	185	18	been	be	AUX
ijpds-4639	185	19	shown	show	VERB
ijpds-4639	185	20	to	to	PART
ijpds-4639	185	21	reduce	reduce	VERB
ijpds-4639	185	22	adiposity	adiposity	NOUN
ijpds-4639	185	23	in	in	ADP
ijpds-4639	185	24	humans	human	NOUN
ijpds-4639	185	25	and	and	CCONJ
ijpds-4639	185	26	rodents	rodent	NOUN
ijpds-4639	185	27	.	.	PUNCT
ijpds-4639	186	1	this	this	DET
ijpds-4639	186	2	reduction	reduction	NOUN
ijpds-4639	186	3	in	in	ADP
ijpds-4639	186	4	adiposity	adiposity	NOUN
ijpds-4639	186	5	is	be	AUX
ijpds-4639	186	6	related	relate	VERB
ijpds-4639	186	7	to	to	PART
ijpds-4639	186	8	decreased	decrease	VERB
ijpds-4639	186	9	food	food	NOUN
ijpds-4639	186	10	intake	intake	NOUN
ijpds-4639	186	11	and	and	CCONJ
ijpds-4639	186	12	reduced	reduced	ADJ
ijpds-4639	186	13	body	body	NOUN
ijpds-4639	186	14	fat	fat	ADJ
ijpds-4639	186	15	gain	gain	NOUN
ijpds-4639	186	16	.	.	PUNCT
ijpds-4639	187	1	in	in	ADP
ijpds-4639	187	2	rodents	rodent	NOUN
ijpds-4639	187	3	,	,	PUNCT
ijpds-4639	187	4	the	the	DET
ijpds-4639	187	5	tpm	tpm	PROPN
ijpds-4639	187	6	treatment	treatment	NOUN
ijpds-4639	187	7	induced	induce	VERB
ijpds-4639	187	8	reduction	reduction	NOUN
ijpds-4639	187	9	in	in	ADP
ijpds-4639	187	10	the	the	DET
ijpds-4639	187	11	molecular	molecular	ADJ
ijpds-4639	187	12	mechanisms	mechanism	NOUN
ijpds-4639	187	13	by	by	ADP
ijpds-4639	187	14	which	which	PRON
ijpds-4639	187	15	tpminduced	tpminduce	VERB
ijpds-4639	187	16	weight	weight	NOUN
ijpds-4639	187	17	loss	loss	NOUN
ijpds-4639	187	18	occurs	occur	VERB
ijpds-4639	187	19	are	be	AUX
ijpds-4639	187	20	contradictory	contradictory	ADJ
ijpds-4639	187	21	and	and	CCONJ
ijpds-4639	187	22	remain	remain	VERB
ijpds-4639	187	23	to	to	PART
ijpds-4639	187	24	be	be	AUX
ijpds-4639	187	25	clarified	clarify	VERB
ijpds-4639	187	26	[	[	X
ijpds-4639	187	27	51	51	NUM
ijpds-4639	187	28	]	]	PUNCT
ijpds-4639	187	29	.	.	PUNCT
ijpds-4639	188	1	conclusion	conclusion	NOUN
ijpds-4639	188	2	obesity	obesity	NOUN
ijpds-4639	188	3	is	be	AUX
ijpds-4639	188	4	a	a	DET
ijpds-4639	188	5	global	global	ADJ
ijpds-4639	188	6	health	health	NOUN
ijpds-4639	188	7	concern	concern	NOUN
ijpds-4639	188	8	till	till	SCONJ
ijpds-4639	188	9	date	date	NOUN
ijpds-4639	188	10	,	,	PUNCT
ijpds-4639	188	11	it	it	PRON
ijpds-4639	188	12	having	have	VERB
ijpds-4639	188	13	such	such	ADJ
ijpds-4639	188	14	strong	strong	ADJ
ijpds-4639	188	15	epidemiological	epidemiological	ADJ
ijpds-4639	188	16	evidences	evidence	NOUN
ijpds-4639	188	17	which	which	PRON
ijpds-4639	188	18	link	link	VERB
ijpds-4639	188	19	it	it	PRON
ijpds-4639	188	20	to	to	ADP
ijpds-4639	188	21	various	various	ADJ
ijpds-4639	188	22	other	other	ADJ
ijpds-4639	188	23	health	health	NOUN
ijpds-4639	188	24	issues	issue	NOUN
ijpds-4639	188	25	.	.	PUNCT
ijpds-4639	189	1	genetic	genetic	ADJ
ijpds-4639	189	2	factors	factor	NOUN
ijpds-4639	189	3	like	like	ADP
ijpds-4639	189	4	mutation	mutation	NOUN
ijpds-4639	189	5	in	in	ADP
ijpds-4639	189	6	leptin	leptin	NOUN
ijpds-4639	189	7	signaling	signal	VERB
ijpds-4639	189	8	plays	play	VERB
ijpds-4639	189	9	an	an	DET
ijpds-4639	189	10	important	important	ADJ
ijpds-4639	189	11	role	role	NOUN
ijpds-4639	189	12	in	in	ADP
ijpds-4639	189	13	obesity	obesity	NOUN
ijpds-4639	189	14	.	.	PUNCT
ijpds-4639	190	1	this	this	PRON
ijpds-4639	190	2	influences	influence	VERB
ijpds-4639	190	3	both	both	CCONJ
ijpds-4639	190	4	somatic	somatic	ADJ
ijpds-4639	190	5	and	and	CCONJ
ijpds-4639	190	6	hereditary	hereditary	ADJ
ijpds-4639	190	7	genomic	genomic	ADJ
ijpds-4639	190	8	events	event	NOUN
ijpds-4639	190	9	.	.	PUNCT
ijpds-4639	191	1	activation	activation	NOUN
ijpds-4639	191	2	of	of	ADP
ijpds-4639	191	3	specific	specific	ADJ
ijpds-4639	191	4	pathways	pathway	NOUN
ijpds-4639	191	5	due	due	ADP
ijpds-4639	191	6	to	to	ADP
ijpds-4639	191	7	metabolic	metabolic	NOUN
ijpds-4639	191	8	shift	shift	NOUN
ijpds-4639	191	9	which	which	PRON
ijpds-4639	191	10	is	be	AUX
ijpds-4639	191	11	associated	associate	VERB
ijpds-4639	191	12	with	with	ADP
ijpds-4639	191	13	obesity	obesity	NOUN
ijpds-4639	191	14	and	and	CCONJ
ijpds-4639	191	15	tumor	tumor	NOUN
ijpds-4639	191	16	progression	progression	NOUN
ijpds-4639	191	17	is	be	AUX
ijpds-4639	191	18	contributed	contribute	VERB
ijpds-4639	191	19	by	by	ADP
ijpds-4639	191	20	these	these	DET
ijpds-4639	191	21	genetic	genetic	ADJ
ijpds-4639	191	22	factors	factor	NOUN
ijpds-4639	191	23	along	along	ADP
ijpds-4639	191	24	with	with	ADP
ijpds-4639	191	25	the	the	DET
ijpds-4639	191	26	gut	gut	NOUN
ijpds-4639	191	27	microbiome	microbiome	NOUN
ijpds-4639	191	28	.	.	PUNCT
ijpds-4639	192	1	comprehensive	comprehensive	ADJ
ijpds-4639	192	2	approaches	approach	NOUN
ijpds-4639	192	3	are	be	AUX
ijpds-4639	192	4	required	require	VERB
ijpds-4639	192	5	to	to	PART
ijpds-4639	192	6	examine	examine	VERB
ijpds-4639	192	7	leptin	leptin	NOUN
ijpds-4639	192	8	’s	’s	PART
ijpds-4639	192	9	role	role	NOUN
ijpds-4639	192	10	in	in	ADP
ijpds-4639	192	11	obesity	obesity	NOUN
ijpds-4639	192	12	can	can	AUX
ijpds-4639	192	13	be	be	AUX
ijpds-4639	192	14	done	do	VERB
ijpds-4639	192	15	by	by	ADP
ijpds-4639	192	16	metagenomics	metagenomic	NOUN
ijpds-4639	192	17	,	,	PUNCT
ijpds-4639	192	18	metatranscriptomics	metatranscriptomic	NOUN
ijpds-4639	192	19	,	,	PUNCT
ijpds-4639	192	20	metaproteomics	metaproteomic	NOUN
ijpds-4639	192	21	and	and	CCONJ
ijpds-4639	192	22	metabolomic	metabolomic	ADJ
ijpds-4639	192	23	studies	study	NOUN
ijpds-4639	192	24	.	.	PUNCT
ijpds-4639	193	1	further	further	ADJ
ijpds-4639	193	2	research	research	NOUN
ijpds-4639	193	3	should	should	AUX
ijpds-4639	193	4	be	be	AUX
ijpds-4639	193	5	targeted	target	VERB
ijpds-4639	193	6	on	on	ADP
ijpds-4639	193	7	the	the	DET
ijpds-4639	193	8	biology	biology	NOUN
ijpds-4639	193	9	of	of	ADP
ijpds-4639	193	10	the	the	DET
ijpds-4639	193	11	leptin	leptin	NOUN
ijpds-4639	193	12	focusing	focus	VERB
ijpds-4639	193	13	more	more	ADV
ijpds-4639	193	14	on	on	ADP
ijpds-4639	193	15	the	the	DET
ijpds-4639	193	16	acquired	acquire	VERB
ijpds-4639	193	17	genetic	genetic	ADJ
ijpds-4639	193	18	variations	variation	NOUN
ijpds-4639	193	19	and	and	CCONJ
ijpds-4639	193	20	understand	understand	VERB
ijpds-4639	193	21	more	more	ADJ
ijpds-4639	193	22	about	about	ADP
ijpds-4639	193	23	there	there	ADV
ijpds-4639	193	24	interaction	interaction	NOUN
ijpds-4639	193	25	with	with	ADP
ijpds-4639	193	26	the	the	DET
ijpds-4639	193	27	gut	gut	NOUN
ijpds-4639	193	28	microbiome	microbiome	NOUN
ijpds-4639	193	29	.	.	PUNCT
ijpds-4639	194	1	longitudinal	longitudinal	ADJ
ijpds-4639	194	2	studies	study	NOUN
ijpds-4639	194	3	focusing	focus	VERB
ijpds-4639	194	4	on	on	ADP
ijpds-4639	194	5	unveiling	unveil	VERB
ijpds-4639	194	6	these	these	DET
ijpds-4639	194	7	factors	factor	NOUN
ijpds-4639	194	8	from	from	ADP
ijpds-4639	194	9	early	early	ADJ
ijpds-4639	194	10	life	life	NOUN
ijpds-4639	194	11	to	to	ADP
ijpds-4639	194	12	adulthood	adulthood	NOUN
ijpds-4639	194	13	may	may	AUX
ijpds-4639	194	14	contribute	contribute	VERB
ijpds-4639	194	15	to	to	ADP
ijpds-4639	194	16	future	future	ADJ
ijpds-4639	194	17	research	research	NOUN
ijpds-4639	194	18	in	in	ADP
ijpds-4639	194	19	building	build	VERB
ijpds-4639	194	20	critical	critical	ADJ
ijpds-4639	194	21	preventive	preventive	ADJ
ijpds-4639	194	22	strategies	strategy	NOUN
ijpds-4639	194	23	,	,	PUNCT
ijpds-4639	194	24	potentially	potentially	ADV
ijpds-4639	194	25	leading	lead	VERB
ijpds-4639	194	26	to	to	ADP
ijpds-4639	194	27	innovative	innovative	ADJ
ijpds-4639	194	28	treatments	treatment	NOUN
ijpds-4639	194	29	and	and	CCONJ
ijpds-4639	194	30	managing	manage	VERB
ijpds-4639	194	31	obesity	obesity	NOUN
ijpds-4639	194	32	in	in	ADP
ijpds-4639	194	33	a	a	DET
ijpds-4639	194	34	better	well	ADJ
ijpds-4639	194	35	way	way	NOUN
ijpds-4639	194	36	.	.	PUNCT
ijpds-4639	195	1	reference	reference	NOUN
ijpds-4639	195	2	1	1	NUM
ijpds-4639	195	3	.	.	PUNCT
ijpds-4639	196	1	wauters	wauter	NOUN
ijpds-4639	196	2	m	m	PROPN
ijpds-4639	196	3	,	,	PUNCT
ijpds-4639	196	4	considine	considine	PROPN
ijpds-4639	196	5	rv	rv	PROPN
ijpds-4639	196	6	,	,	PUNCT
ijpds-4639	196	7	van	van	PROPN
ijpds-4639	196	8	gaal	gaal	PROPN
ijpds-4639	196	9	lf	lf	PROPN
ijpds-4639	196	10	.	.	PUNCT
ijpds-4639	197	1	human	human	ADJ
ijpds-4639	197	2	leptin	leptin	PROPN
ijpds-4639	197	3	:	:	PUNCT
ijpds-4639	197	4	from	from	ADP
ijpds-4639	197	5	an	an	DET
ijpds-4639	197	6	adipocyte	adipocyte	ADJ
ijpds-4639	197	7	hormone	hormone	NOUN
ijpds-4639	197	8	to	to	ADP
ijpds-4639	197	9	an	an	DET
ijpds-4639	197	10	endocrine	endocrine	NOUN
ijpds-4639	197	11	mediator	mediator	NOUN
ijpds-4639	197	12	.	.	PUNCT
ijpds-4639	198	1	european	european	PROPN
ijpds-4639	198	2	journal	journal	PROPN
ijpds-4639	198	3	of	of	ADP
ijpds-4639	198	4	endocrinology	endocrinology	NOUN
ijpds-4639	198	5	.	.	PUNCT
ijpds-4639	199	1	2000	2000	NUM
ijpds-4639	199	2	;	;	PUNCT
ijpds-4639	199	3	143(3):293	143(3):293	NUM
ijpds-4639	199	4	-	-	SYM
ijpds-4639	199	5	311	311	NUM
ijpds-4639	199	6	.	.	PUNCT
ijpds-4639	200	1	doi:10.1530	doi:10.1530	NOUN
ijpds-4639	200	2	/	/	SYM
ijpds-4639	200	3	eje.0.1430293	eje.0.1430293	PROPN
ijpds-4639	200	4	2	2	NUM
ijpds-4639	200	5	.	.	PUNCT
ijpds-4639	200	6	lee	lee	PROPN
ijpds-4639	200	7	gh	gh	PROPN
ijpds-4639	200	8	,	,	PUNCT
ijpds-4639	200	9	proenca	proenca	PROPN
ijpds-4639	200	10	r	r	PROPN
ijpds-4639	200	11	,	,	PUNCT
ijpds-4639	200	12	montez	montez	PROPN
ijpds-4639	200	13	jm	jm	PROPN
ijpds-4639	200	14	,	,	PUNCT
ijpds-4639	200	15	et	et	PROPN
ijpds-4639	200	16	al	al	PROPN
ijpds-4639	200	17	.	.	PROPN
ijpds-4639	200	18	abnormal	abnormal	ADJ
ijpds-4639	200	19	splicing	splicing	NOUN
ijpds-4639	200	20	of	of	ADP
ijpds-4639	200	21	the	the	DET
ijpds-4639	200	22	leptin	leptin	NOUN
ijpds-4639	200	23	receptor	receptor	NOUN
ijpds-4639	200	24	in	in	ADP
ijpds-4639	200	25	diabetic	diabetic	ADJ
ijpds-4639	200	26	mice	mouse	NOUN
ijpds-4639	200	27	.	.	PUNCT
ijpds-4639	201	1	nature	nature	NOUN
ijpds-4639	201	2	.	.	PUNCT
ijpds-4639	202	1	1996	1996	NUM
ijpds-4639	202	2	;	;	PUNCT
ijpds-4639	202	3	379(6566):632	379(6566):632	NUM
ijpds-4639	202	4	-	-	SYM
ijpds-4639	202	5	5	5	NUM
ijpds-4639	202	6	.	.	PUNCT
ijpds-4639	203	1	doi:10.1038/379632a0	doi:10.1038/379632a0	VERB
ijpds-4639	204	1	3	3	NUM
ijpds-4639	204	2	.	.	X
ijpds-4639	204	3	bates	bates	PROPN
ijpds-4639	204	4	sh	sh	PROPN
ijpds-4639	204	5	,	,	PUNCT
ijpds-4639	204	6	stearns	stearns	PROPN
ijpds-4639	204	7	wh	wh	PROPN
ijpds-4639	204	8	,	,	PUNCT
ijpds-4639	204	9	dundon	dundon	PROPN
ijpds-4639	204	10	ta	ta	PROPN
ijpds-4639	204	11	,	,	PUNCT
ijpds-4639	204	12	et	et	PROPN
ijpds-4639	204	13	al	al	PROPN
ijpds-4639	204	14	.	.	PUNCT
ijpds-4639	205	1	stat3	stat3	NOUN
ijpds-4639	205	2	signalling	signal	VERB
ijpds-4639	205	3	is	be	AUX
ijpds-4639	205	4	required	require	VERB
ijpds-4639	205	5	for	for	ADP
ijpds-4639	205	6	leptin	leptin	NOUN
ijpds-4639	205	7	regulation	regulation	NOUN
ijpds-4639	205	8	of	of	ADP
ijpds-4639	205	9	energy	energy	NOUN
ijpds-4639	205	10	balance	balance	NOUN
ijpds-4639	205	11	but	but	CCONJ
ijpds-4639	205	12	not	not	PART
ijpds-4639	205	13	reproduction	reproduction	NOUN
ijpds-4639	205	14	.	.	PUNCT
ijpds-4639	206	1	nature	nature	NOUN
ijpds-4639	206	2	.	.	PUNCT
ijpds-4639	207	1	2003	2003	NUM
ijpds-4639	207	2	;	;	PUNCT
ijpds-4639	207	3	421(6925):856	421(6925):856	NUM
ijpds-4639	207	4	-	-	SYM
ijpds-4639	207	5	9	9	NUM
ijpds-4639	207	6	.	.	PUNCT
ijpds-4639	207	7	doi:10.1038	doi:10.1038	NOUN
ijpds-4639	207	8	/	/	SYM
ijpds-4639	207	9	nature01388	nature01388	PROPN
ijpds-4639	207	10	4	4	NUM
ijpds-4639	207	11	.	.	PUNCT
ijpds-4639	207	12	morton	morton	PROPN
ijpds-4639	207	13	gj	gj	PROPN
ijpds-4639	207	14	,	,	PUNCT
ijpds-4639	207	15	gelling	gel	VERB
ijpds-4639	207	16	rw	rw	NOUN
ijpds-4639	207	17	,	,	PUNCT
ijpds-4639	207	18	niswender	niswender	NOUN
ijpds-4639	207	19	kd	kd	PROPN
ijpds-4639	207	20	,	,	PUNCT
ijpds-4639	207	21	et	et	PROPN
ijpds-4639	207	22	al	al	PROPN
ijpds-4639	207	23	.	.	PROPN
ijpds-4639	207	24	leptin	leptin	PROPN
ijpds-4639	207	25	regulates	regulate	VERB
ijpds-4639	207	26	insulin	insulin	NOUN
ijpds-4639	207	27	sensitivity	sensitivity	NOUN
ijpds-4639	207	28	via	via	ADP
ijpds-4639	207	29	phosphatidylinositol-3	phosphatidylinositol-3	PROPN
ijpds-4639	207	30	-	-	PUNCT
ijpds-4639	207	31	oh	oh	NUM
ijpds-4639	207	32	kinase	kinase	NOUN
ijpds-4639	207	33	signaling	signal	VERB
ijpds-4639	207	34	in	in	ADP
ijpds-4639	207	35	mediobasal	mediobasal	ADJ
ijpds-4639	207	36	hypothalamic	hypothalamic	ADJ
ijpds-4639	207	37	neurons	neuron	NOUN
ijpds-4639	207	38	.	.	PUNCT
ijpds-4639	208	1	cell	cell	NOUN
ijpds-4639	208	2	metabolism	metabolism	NOUN
ijpds-4639	208	3	.	.	PUNCT
ijpds-4639	209	1	2005	2005	NUM
ijpds-4639	209	2	;	;	PUNCT
ijpds-4639	209	3	2(6):411	2(6):411	NUM
ijpds-4639	209	4	-	-	SYM
ijpds-4639	209	5	20	20	NUM
ijpds-4639	209	6	.	.	PUNCT
ijpds-4639	210	1	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	210	2	/	/	SYM
ijpds-4639	210	3	j.cmet.2005.10.009	j.cmet.2005.10.009	PROPN
ijpds-4639	210	4	5	5	NUM
ijpds-4639	210	5	.	.	PUNCT
ijpds-4639	211	1	farr	farr	PROPN
ijpds-4639	211	2	om	om	PROPN
ijpds-4639	211	3	,	,	PUNCT
ijpds-4639	211	4	gavrieli	gavrieli	VERB
ijpds-4639	211	5	a	a	PRON
ijpds-4639	211	6	,	,	PUNCT
ijpds-4639	211	7	mantzoros	mantzoros	PROPN
ijpds-4639	211	8	cs	cs	PROPN
ijpds-4639	211	9	.	.	PROPN
ijpds-4639	211	10	leptin	leptin	PROPN
ijpds-4639	211	11	applications	application	NOUN
ijpds-4639	211	12	in	in	ADP
ijpds-4639	211	13	2015	2015	NUM
ijpds-4639	211	14	:	:	PUNCT
ijpds-4639	211	15	what	what	PRON
ijpds-4639	211	16	have	have	AUX
ijpds-4639	211	17	we	we	PRON
ijpds-4639	211	18	learned	learn	VERB
ijpds-4639	211	19	about	about	ADP
ijpds-4639	211	20	leptin	leptin	NOUN
ijpds-4639	211	21	and	and	CCONJ
ijpds-4639	211	22	obesity	obesity	NOUN
ijpds-4639	211	23	?	?	PUNCT
ijpds-4639	211	24	.	.	PUNCT
ijpds-4639	212	1	current	current	ADJ
ijpds-4639	212	2	opinion	opinion	NOUN
ijpds-4639	212	3	in	in	ADP
ijpds-4639	212	4	endocrinology	endocrinology	NOUN
ijpds-4639	212	5	,	,	PUNCT
ijpds-4639	212	6	diabetes	diabetes	NOUN
ijpds-4639	212	7	and	and	CCONJ
ijpds-4639	212	8	obesity	obesity	NOUN
ijpds-4639	212	9	.	.	PUNCT
ijpds-4639	212	10	2015	2015	NUM
ijpds-4639	212	11	;	;	PUNCT
ijpds-4639	212	12	22(5):353	22(5):353	PROPN
ijpds-4639	212	13	-	-	SYM
ijpds-4639	212	14	9	9	NUM
ijpds-4639	212	15	.	.	PUNCT
ijpds-4639	212	16	doi	doi	NOUN
ijpds-4639	212	17	:	:	PUNCT
ijpds-4639	212	18	10.1097	10.1097	NUM
ijpds-4639	212	19	/	/	SYM
ijpds-4639	212	20	med.0000000000000184	med.0000000000000184	NUM
ijpds-4639	212	21	6	6	NUM
ijpds-4639	212	22	.	.	PUNCT
ijpds-4639	212	23	yazdi	yazdi	PROPN
ijpds-4639	212	24	ft	ft	PROPN
ijpds-4639	212	25	,	,	PUNCT
ijpds-4639	212	26	clee	clee	PROPN
ijpds-4639	212	27	sm	sm	PROPN
ijpds-4639	212	28	,	,	PUNCT
ijpds-4639	212	29	meyre	meyre	PROPN
ijpds-4639	212	30	d.	d.	PROPN
ijpds-4639	212	31	obesity	obesity	PROPN
ijpds-4639	212	32	genetics	genetic	NOUN
ijpds-4639	212	33	in	in	ADP
ijpds-4639	212	34	mouse	mouse	NOUN
ijpds-4639	212	35	and	and	CCONJ
ijpds-4639	212	36	human	human	NOUN
ijpds-4639	212	37	:	:	PUNCT
ijpds-4639	212	38	back	back	ADV
ijpds-4639	212	39	and	and	CCONJ
ijpds-4639	212	40	forth	forth	ADV
ijpds-4639	212	41	,	,	PUNCT
ijpds-4639	212	42	and	and	CCONJ
ijpds-4639	212	43	back	back	ADV
ijpds-4639	212	44	again	again	ADV
ijpds-4639	212	45	.	.	PUNCT
ijpds-4639	213	1	peerj	peerj	PROPN
ijpds-4639	213	2	.	.	PUNCT
ijpds-4639	214	1	2015	2015	NUM
ijpds-4639	214	2	;	;	PUNCT
ijpds-4639	214	3	3	3	NUM
ijpds-4639	214	4	:	:	PUNCT
ijpds-4639	214	5	e856	e856	PROPN
ijpds-4639	214	6	.	.	PUNCT
ijpds-4639	214	7	doi	doi	PROPN
ijpds-4639	214	8	:	:	PUNCT
ijpds-4639	214	9	10.7717	10.7717	NUM
ijpds-4639	214	10	/	/	SYM
ijpds-4639	214	11	peerj.856	peerj.856	PROPN
ijpds-4639	214	12	7	7	NUM
ijpds-4639	214	13	.	.	PUNCT
ijpds-4639	215	1	dubern	dubern	PROPN
ijpds-4639	215	2	b	b	PROPN
ijpds-4639	215	3	,	,	PUNCT
ijpds-4639	215	4	clement	clement	PROPN
ijpds-4639	215	5	k.	k.	PROPN
ijpds-4639	215	6	leptin	leptin	PROPN
ijpds-4639	215	7	and	and	CCONJ
ijpds-4639	215	8	leptin	leptin	VERB
ijpds-4639	215	9	receptor	receptor	NOUN
ijpds-4639	215	10	-	-	PUNCT
ijpds-4639	215	11	related	relate	VERB
ijpds-4639	215	12	monogenic	monogenic	ADJ
ijpds-4639	215	13	obesity	obesity	NOUN
ijpds-4639	215	14	.	.	PUNCT
ijpds-4639	216	1	biochimie	biochimie	PROPN
ijpds-4639	216	2	.	.	PUNCT
ijpds-4639	217	1	2012	2012	NUM
ijpds-4639	217	2	;	;	PUNCT
ijpds-4639	217	3	94(10):2111	94(10):2111	X
ijpds-4639	217	4	-	-	SYM
ijpds-4639	217	5	5	5	NUM
ijpds-4639	217	6	.	.	PUNCT
ijpds-4639	218	1	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	218	2	/	/	SYM
ijpds-4639	218	3	j.biochi.2012.05.010	j.biochi.2012.05.010	PROPN
ijpds-4639	218	4	8	8	NUM
ijpds-4639	218	5	.	.	PUNCT
ijpds-4639	219	1	izquierdo	izquierdo	PROPN
ijpds-4639	219	2	ag	ag	PROPN
ijpds-4639	219	3	,	,	PUNCT
ijpds-4639	219	4	crujeiras	crujeiras	PROPN
ijpds-4639	219	5	ab	ab	PROPN
ijpds-4639	219	6	,	,	PUNCT
ijpds-4639	219	7	casanueva	casanueva	PROPN
ijpds-4639	219	8	ff	ff	PROPN
ijpds-4639	219	9	,	,	PUNCT
ijpds-4639	219	10	et	et	PROPN
ijpds-4639	219	11	al	al	PROPN
ijpds-4639	219	12	.	.	PROPN
ijpds-4639	219	13	leptin	leptin	PROPN
ijpds-4639	219	14	,	,	PUNCT
ijpds-4639	219	15	obesity	obesity	NOUN
ijpds-4639	219	16	,	,	PUNCT
ijpds-4639	219	17	and	and	CCONJ
ijpds-4639	219	18	leptin	leptin	NOUN
ijpds-4639	219	19	resistance	resistance	NOUN
ijpds-4639	219	20	:	:	PUNCT
ijpds-4639	219	21	where	where	SCONJ
ijpds-4639	219	22	are	be	AUX
ijpds-4639	219	23	we	we	PRON
ijpds-4639	219	24	25	25	NUM
ijpds-4639	219	25	years	year	NOUN
ijpds-4639	219	26	later	later	ADV
ijpds-4639	219	27	?	?	PUNCT
ijpds-4639	220	1	nutrients	nutrient	NOUN
ijpds-4639	220	2	.	.	PUNCT
ijpds-4639	221	1	2019	2019	NUM
ijpds-4639	221	2	;	;	PUNCT
ijpds-4639	221	3	11(11):2704	11(11):2704	X
ijpds-4639	221	4	.	.	X
ijpds-4639	221	5	doi	doi	NOUN
ijpds-4639	221	6	:	:	PUNCT
ijpds-4639	221	7	10.3390	10.3390	NUM
ijpds-4639	221	8	/	/	SYM
ijpds-4639	221	9	nu11112704	nu11112704	NOUN
ijpds-4639	221	10	9	9	NUM
ijpds-4639	221	11	.	.	PUNCT
ijpds-4639	222	1	liu	liu	PROPN
ijpds-4639	222	2	w	w	PROPN
ijpds-4639	222	3	,	,	PUNCT
ijpds-4639	222	4	zhou	zhou	PROPN
ijpds-4639	222	5	x	x	PROPN
ijpds-4639	222	6	,	,	PUNCT
ijpds-4639	222	7	li	li	PROPN
ijpds-4639	222	8	y	y	PROPN
ijpds-4639	222	9	,	,	PUNCT
ijpds-4639	222	10	et	et	PROPN
ijpds-4639	222	11	al	al	PROPN
ijpds-4639	222	12	.	.	PROPN
ijpds-4639	222	13	serum	serum	PROPN
ijpds-4639	222	14	leptin	leptin	PROPN
ijpds-4639	222	15	,	,	PUNCT
ijpds-4639	222	16	resistin	resistin	NOUN
ijpds-4639	222	17	,	,	PUNCT
ijpds-4639	222	18	and	and	CCONJ
ijpds-4639	222	19	adiponectin	adiponectin	NOUN
ijpds-4639	222	20	levels	level	NOUN
ijpds-4639	222	21	in	in	ADP
ijpds-4639	222	22	obese	obese	ADJ
ijpds-4639	222	23	and	and	CCONJ
ijpds-4639	222	24	non	non	ADJ
ijpds-4639	222	25	-	-	ADJ
ijpds-4639	222	26	obese	obese	ADJ
ijpds-4639	222	27	patients	patient	NOUN
ijpds-4639	222	28	with	with	ADP
ijpds-4639	222	29	newly	newly	ADV
ijpds-4639	222	30	diagnosed	diagnose	VERB
ijpds-4639	222	31	type	type	NOUN
ijpds-4639	222	32	2	2	NUM
ijpds-4639	222	33	diabetes	diabetes	NOUN
ijpds-4639	222	34	mellitus	mellitus	NOUN
ijpds-4639	222	35	:	:	PUNCT
ijpds-4639	222	36	a	a	DET
ijpds-4639	222	37	population	population	NOUN
ijpds-4639	222	38	-	-	PUNCT
ijpds-4639	222	39	based	base	VERB
ijpds-4639	222	40	study	study	NOUN
ijpds-4639	222	41	.	.	PUNCT
ijpds-4639	223	1	medicine	medicine	NOUN
ijpds-4639	223	2	.	.	PUNCT
ijpds-4639	224	1	2020	2020	NUM
ijpds-4639	224	2	;	;	PUNCT
ijpds-4639	224	3	99(6):e19052	99(6):e19052	X
ijpds-4639	224	4	.	.	PUNCT
ijpds-4639	225	1	doi	doi	PROPN
ijpds-4639	225	2	:	:	PUNCT
ijpds-4639	225	3	10.1097	10.1097	NUM
ijpds-4639	225	4	/	/	SYM
ijpds-4639	225	5	md.0000000000019052	md.0000000000019052	PROPN
ijpds-4639	225	6	.	.	PROPN
ijpds-4639	226	1	10	10	NUM
ijpds-4639	226	2	.	.	PUNCT
ijpds-4639	226	3	bhui	bhui	PROPN
ijpds-4639	226	4	u	u	PROPN
ijpds-4639	226	5	,	,	PUNCT
ijpds-4639	226	6	sarkar	sarkar	PROPN
ijpds-4639	226	7	s	s	PROPN
ijpds-4639	226	8	,	,	PUNCT
ijpds-4639	226	9	das	das	PROPN
ijpds-4639	226	10	j	j	PROPN
ijpds-4639	226	11	,	,	PUNCT
ijpds-4639	226	12	et	et	PROPN
ijpds-4639	226	13	al	al	PROPN
ijpds-4639	226	14	.	.	PUNCT
ijpds-4639	227	1	unraveling	unravel	VERB
ijpds-4639	227	2	the	the	DET
ijpds-4639	227	3	enigma	enigma	NOUN
ijpds-4639	227	4	of	of	ADP
ijpds-4639	227	5	antitubercular	antitubercular	ADJ
ijpds-4639	227	6	drug	drug	NOUN
ijpds-4639	227	7	-	-	PUNCT
ijpds-4639	227	8	induced	induce	VERB
ijpds-4639	227	9	vitamin	vitamin	NOUN
ijpds-4639	227	10	b6	b6	NOUN
ijpds-4639	227	11	deficiency	deficiency	NOUN
ijpds-4639	227	12	and	and	CCONJ
ijpds-4639	227	13	its	its	PRON
ijpds-4639	227	14	role	role	NOUN
ijpds-4639	227	15	in	in	ADP
ijpds-4639	227	16	provoking	provoke	VERB
ijpds-4639	227	17	convulsive	convulsive	ADJ
ijpds-4639	227	18	seizures	seizure	NOUN
ijpds-4639	227	19	:	:	PUNCT
ijpds-4639	227	20	a	a	DET
ijpds-4639	227	21	revelatory	revelatory	ADJ
ijpds-4639	227	22	case	case	NOUN
ijpds-4639	227	23	report	report	NOUN
ijpds-4639	227	24	.	.	PUNCT
ijpds-4639	228	1	indian	indian	ADJ
ijpds-4639	228	2	journal	journal	PROPN
ijpds-4639	228	3	of	of	ADP
ijpds-4639	228	4	pharmacy	pharmacy	PROPN
ijpds-4639	228	5	&	&	CCONJ
ijpds-4639	228	6	drug	drug	NOUN
ijpds-4639	228	7	studies	study	NOUN
ijpds-4639	228	8	.	.	PUNCT
ijpds-4639	229	1	2023	2023	NUM
ijpds-4639	229	2	;	;	PUNCT
ijpds-4639	229	3	2(3):124	2(3):124	NUM
ijpds-4639	229	4	-	-	SYM
ijpds-4639	229	5	6	6	NUM
ijpds-4639	229	6	.	.	PUNCT
ijpds-4639	229	7	https://mansapublishers.com/index.php/ijpds/article/view/4052/3	https://mansapublishers.com/index.php/ijpds/article/view/4052/3	NOUN
ijpds-4639	230	1	488	488	NUM
ijpds-4639	230	2	https://doi.org/10.1530/eje.0.1430293	https://doi.org/10.1530/eje.0.1430293	PROPN
ijpds-4639	230	3	https://mansapublishers.com/index.php/ijpds/article/view/4052/3488	https://mansapublishers.com/index.php/ijpds/article/view/4052/3488	PROPN
ijpds-4639	230	4	https://mansapublishers.com/index.php/ijpds/article/view/4052/3488	https://mansapublishers.com/index.php/ijpds/article/view/4052/3488	PROPN
ijpds-4639	230	5	singha	singha	PROPN
ijpds-4639	230	6	et	et	PROPN
ijpds-4639	230	7	al	al	PROPN
ijpds-4639	230	8	.	.	PROPN
ijpds-4639	230	9	leptin	leptin	PROPN
ijpds-4639	230	10	:	:	PUNCT
ijpds-4639	230	11	its	its	PRON
ijpds-4639	230	12	crucial	crucial	ADJ
ijpds-4639	230	13	role	role	NOUN
ijpds-4639	230	14	in	in	ADP
ijpds-4639	230	15	the	the	DET
ijpds-4639	230	16	fight	fight	NOUN
ijpds-4639	230	17	against	against	ADP
ijpds-4639	230	18	obesity	obesity	NOUN
ijpds-4639	230	19	online	online	ADJ
ijpds-4639	230	20	first	first	PROPN
ijpds-4639	230	21	indian	indian	PROPN
ijpds-4639	230	22	j	j	PROPN
ijpds-4639	230	23	pharm	pharm	PROPN
ijpds-4639	230	24	drug	drug	PROPN
ijpds-4639	230	25	studies	study	NOUN
ijpds-4639	230	26	|	|	ADV
ijpds-4639	230	27	6	6	NUM
ijpds-4639	230	28	11	11	NUM
ijpds-4639	230	29	.	.	PUNCT
ijpds-4639	231	1	lönnqvist	lönnqvist	PROPN
ijpds-4639	231	2	f	f	PROPN
ijpds-4639	231	3	,	,	PUNCT
ijpds-4639	231	4	arner	arner	NOUN
ijpds-4639	231	5	p	p	NOUN
ijpds-4639	231	6	,	,	PUNCT
ijpds-4639	231	7	nordfors	nordfor	NOUN
ijpds-4639	231	8	l	l	PROPN
ijpds-4639	231	9	,	,	PUNCT
ijpds-4639	231	10	et	et	PROPN
ijpds-4639	231	11	al	al	PROPN
ijpds-4639	231	12	.	.	PROPN
ijpds-4639	232	1	overexpression	overexpression	NOUN
ijpds-4639	232	2	of	of	ADP
ijpds-4639	232	3	the	the	DET
ijpds-4639	232	4	obese	obese	NOUN
ijpds-4639	232	5	(	(	PUNCT
ijpds-4639	232	6	ob	ob	NOUN
ijpds-4639	232	7	)	)	PUNCT
ijpds-4639	232	8	gene	gene	NOUN
ijpds-4639	232	9	in	in	ADP
ijpds-4639	232	10	adipose	adipose	ADJ
ijpds-4639	232	11	tissue	tissue	NOUN
ijpds-4639	232	12	of	of	ADP
ijpds-4639	232	13	human	human	ADJ
ijpds-4639	232	14	obese	obese	ADJ
ijpds-4639	232	15	subjects	subject	NOUN
ijpds-4639	232	16	.	.	PUNCT
ijpds-4639	233	1	nature	nature	NOUN
ijpds-4639	233	2	medicine	medicine	NOUN
ijpds-4639	233	3	.	.	PUNCT
ijpds-4639	234	1	1995	1995	NUM
ijpds-4639	234	2	;	;	PUNCT
ijpds-4639	234	3	1(9):950	1(9):950	NUM
ijpds-4639	234	4	-	-	SYM
ijpds-4639	234	5	3	3	NUM
ijpds-4639	234	6	.	.	PUNCT
ijpds-4639	234	7	doi	doi	NOUN
ijpds-4639	234	8	:	:	PUNCT
ijpds-4639	234	9	10.1038	10.1038	NUM
ijpds-4639	234	10	/	/	SYM
ijpds-4639	234	11	nm0995	nm0995	PROPN
ijpds-4639	234	12	-	-	PUNCT
ijpds-4639	234	13	950	950	NUM
ijpds-4639	234	14	12	12	NUM
ijpds-4639	234	15	.	.	PUNCT
ijpds-4639	235	1	sáinz	sáinz	PROPN
ijpds-4639	235	2	n	n	CCONJ
ijpds-4639	235	3	,	,	PUNCT
ijpds-4639	235	4	barrenetxe	barrenetxe	PROPN
ijpds-4639	235	5	j	j	PROPN
ijpds-4639	235	6	,	,	PUNCT
ijpds-4639	235	7	moreno	moreno	PROPN
ijpds-4639	235	8	-	-	PUNCT
ijpds-4639	235	9	aliaga	aliaga	PROPN
ijpds-4639	235	10	mj	mj	PROPN
ijpds-4639	235	11	,	,	PUNCT
ijpds-4639	235	12	et	et	PROPN
ijpds-4639	235	13	al	al	PROPN
ijpds-4639	235	14	.	.	PROPN
ijpds-4639	235	15	leptin	leptin	PROPN
ijpds-4639	235	16	resistance	resistance	NOUN
ijpds-4639	235	17	and	and	CCONJ
ijpds-4639	235	18	diet	diet	NOUN
ijpds-4639	235	19	-	-	PUNCT
ijpds-4639	235	20	induced	induce	VERB
ijpds-4639	235	21	obesity	obesity	NOUN
ijpds-4639	235	22	:	:	PUNCT
ijpds-4639	235	23	central	central	ADJ
ijpds-4639	235	24	and	and	CCONJ
ijpds-4639	235	25	peripheral	peripheral	ADJ
ijpds-4639	235	26	actions	action	NOUN
ijpds-4639	235	27	of	of	ADP
ijpds-4639	235	28	leptin	leptin	NOUN
ijpds-4639	235	29	.	.	PUNCT
ijpds-4639	236	1	metabolism	metabolism	NOUN
ijpds-4639	236	2	.	.	PUNCT
ijpds-4639	237	1	2015	2015	NUM
ijpds-4639	237	2	;	;	PUNCT
ijpds-4639	237	3	64(1):35	64(1):35	PROPN
ijpds-4639	237	4	-	-	SYM
ijpds-4639	237	5	46	46	NUM
ijpds-4639	237	6	.	.	PUNCT
ijpds-4639	238	1	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	238	2	/	/	SYM
ijpds-4639	238	3	j.metabol.2014.10.015	j.metabol.2014.10.015	PROPN
ijpds-4639	238	4	13	13	NUM
ijpds-4639	238	5	.	.	PUNCT
ijpds-4639	239	1	matheny	matheny	PROPN
ijpds-4639	239	2	m	m	PROPN
ijpds-4639	239	3	,	,	PUNCT
ijpds-4639	239	4	shapiro	shapiro	PROPN
ijpds-4639	239	5	a	a	PRON
ijpds-4639	239	6	,	,	PUNCT
ijpds-4639	239	7	tümer	tümer	NOUN
ijpds-4639	239	8	n	n	CCONJ
ijpds-4639	239	9	,	,	PUNCT
ijpds-4639	239	10	et	et	PROPN
ijpds-4639	239	11	al	al	PROPN
ijpds-4639	239	12	.	.	PUNCT
ijpds-4639	239	13	region	region	NOUN
ijpds-4639	239	14	-	-	PUNCT
ijpds-4639	239	15	specific	specific	ADJ
ijpds-4639	239	16	dietinduced	dietinduce	VERB
ijpds-4639	239	17	and	and	CCONJ
ijpds-4639	239	18	leptin	leptin	NOUN
ijpds-4639	239	19	-	-	PUNCT
ijpds-4639	239	20	induced	induce	VERB
ijpds-4639	239	21	cellular	cellular	ADJ
ijpds-4639	239	22	leptin	leptin	NOUN
ijpds-4639	239	23	resistance	resistance	NOUN
ijpds-4639	239	24	includes	include	VERB
ijpds-4639	239	25	the	the	DET
ijpds-4639	239	26	ventral	ventral	ADJ
ijpds-4639	239	27	tegmental	tegmental	ADJ
ijpds-4639	239	28	area	area	NOUN
ijpds-4639	239	29	in	in	ADP
ijpds-4639	239	30	rats	rat	NOUN
ijpds-4639	239	31	.	.	PUNCT
ijpds-4639	240	1	neuropharmacology	neuropharmacology	NOUN
ijpds-4639	240	2	.	.	PUNCT
ijpds-4639	241	1	2011	2011	NUM
ijpds-4639	241	2	;	;	PUNCT
ijpds-4639	242	1	60(23):480	60(23):480	NUM
ijpds-4639	242	2	-	-	SYM
ijpds-4639	242	3	7	7	NUM
ijpds-4639	242	4	.	.	PUNCT
ijpds-4639	242	5	doi	doi	NOUN
ijpds-4639	242	6	:	:	PUNCT
ijpds-4639	242	7	10.1016	10.1016	NUM
ijpds-4639	242	8	/	/	SYM
ijpds-4639	242	9	j.neuropharm.2010.11.002	j.neuropharm.2010.11.002	PROPN
ijpds-4639	242	10	14	14	NUM
ijpds-4639	242	11	.	.	PUNCT
ijpds-4639	243	1	hirasawa	hirasawa	PROPN
ijpds-4639	243	2	t	t	PROPN
ijpds-4639	243	3	,	,	PUNCT
ijpds-4639	243	4	ohara	ohara	PROPN
ijpds-4639	243	5	t	t	PROPN
ijpds-4639	243	6	,	,	PUNCT
ijpds-4639	243	7	makino	makino	PROPN
ijpds-4639	243	8	s.	s.	PROPN
ijpds-4639	243	9	genetic	genetic	ADJ
ijpds-4639	243	10	typing	typing	NOUN
ijpds-4639	243	11	of	of	ADP
ijpds-4639	243	12	the	the	DET
ijpds-4639	243	13	mouse	mouse	PROPN
ijpds-4639	243	14	ob	ob	NOUN
ijpds-4639	243	15	mutation	mutation	NOUN
ijpds-4639	243	16	by	by	ADP
ijpds-4639	243	17	pcr	pcr	ADJ
ijpds-4639	243	18	and	and	CCONJ
ijpds-4639	243	19	restriction	restriction	NOUN
ijpds-4639	243	20	enzyme	enzyme	NOUN
ijpds-4639	243	21	analysis	analysis	NOUN
ijpds-4639	243	22	.	.	PUNCT
ijpds-4639	244	1	experimental	experimental	ADJ
ijpds-4639	244	2	animals	animal	NOUN
ijpds-4639	244	3	.	.	PUNCT
ijpds-4639	245	1	1997	1997	NUM
ijpds-4639	245	2	;	;	PUNCT
ijpds-4639	246	1	46(1):75	46(1):75	NUM
ijpds-4639	246	2	-	-	SYM
ijpds-4639	246	3	8	8	NUM
ijpds-4639	246	4	.	.	PUNCT
ijpds-4639	246	5	doi:10.1538	doi:10.1538	NOUN
ijpds-4639	246	6	/	/	SYM
ijpds-4639	246	7	expanim.46.75	expanim.46.75	ADJ
ijpds-4639	246	8	15	15	NUM
ijpds-4639	246	9	.	.	PUNCT
ijpds-4639	246	10	igel	igel	NOUN
ijpds-4639	246	11	m	m	PROPN
ijpds-4639	246	12	,	,	PUNCT
ijpds-4639	246	13	becker	becker	PROPN
ijpds-4639	246	14	w	w	PROPN
ijpds-4639	246	15	,	,	PUNCT
ijpds-4639	246	16	herberg	herberg	PROPN
ijpds-4639	246	17	l	l	NOUN
ijpds-4639	246	18	,	,	PUNCT
ijpds-4639	246	19	et	et	PROPN
ijpds-4639	246	20	al	al	PROPN
ijpds-4639	246	21	.	.	PROPN
ijpds-4639	246	22	hyperleptinemia	hyperleptinemia	PROPN
ijpds-4639	246	23	,	,	PUNCT
ijpds-4639	246	24	leptin	leptin	NOUN
ijpds-4639	246	25	resistance	resistance	NOUN
ijpds-4639	246	26	,	,	PUNCT
ijpds-4639	246	27	and	and	CCONJ
ijpds-4639	246	28	polymorphic	polymorphic	ADJ
ijpds-4639	246	29	leptin	leptin	NOUN
ijpds-4639	246	30	receptor	receptor	NOUN
ijpds-4639	246	31	in	in	ADP
ijpds-4639	246	32	the	the	DET
ijpds-4639	246	33	new	new	PROPN
ijpds-4639	246	34	zealand	zealand	PROPN
ijpds-4639	246	35	obese	obese	PROPN
ijpds-4639	246	36	mouse	mouse	PROPN
ijpds-4639	246	37	.	.	PUNCT
ijpds-4639	247	1	endocrinology	endocrinology	NOUN
ijpds-4639	247	2	.	.	PUNCT
ijpds-4639	248	1	1997	1997	NUM
ijpds-4639	248	2	;	;	PUNCT
ijpds-4639	248	3	138(10):4234	138(10):4234	X
ijpds-4639	248	4	-	-	SYM
ijpds-4639	248	5	9	9	NUM
ijpds-4639	248	6	.	.	PUNCT
ijpds-4639	248	7	doi	doi	NOUN
ijpds-4639	248	8	:	:	PUNCT
ijpds-4639	248	9	10.1210	10.1210	NUM
ijpds-4639	248	10	/	/	SYM
ijpds-4639	248	11	endo	endo	NOUN
ijpds-4639	248	12	.	.	PUNCT
ijpds-4639	249	1	138.10.5428	138.10.5428	NUM
ijpds-4639	249	2	16	16	NUM
ijpds-4639	249	3	.	.	PUNCT
ijpds-4639	250	1	lee	lee	PROPN
ijpds-4639	250	2	gh	gh	PROPN
ijpds-4639	250	3	,	,	PUNCT
ijpds-4639	250	4	proenca	proenca	PROPN
ijpds-4639	250	5	r	r	PROPN
ijpds-4639	250	6	,	,	PUNCT
ijpds-4639	250	7	montez	montez	PROPN
ijpds-4639	250	8	jm	jm	PROPN
ijpds-4639	250	9	,	,	PUNCT
ijpds-4639	250	10	et	et	PROPN
ijpds-4639	250	11	al	al	PROPN
ijpds-4639	250	12	.	.	PROPN
ijpds-4639	250	13	abnormal	abnormal	ADJ
ijpds-4639	250	14	splicing	splicing	NOUN
ijpds-4639	250	15	of	of	ADP
ijpds-4639	250	16	the	the	DET
ijpds-4639	250	17	leptin	leptin	NOUN
ijpds-4639	250	18	receptor	receptor	NOUN
ijpds-4639	250	19	in	in	ADP
ijpds-4639	250	20	diabetic	diabetic	ADJ
ijpds-4639	250	21	mice	mouse	NOUN
ijpds-4639	250	22	.	.	PUNCT
ijpds-4639	251	1	nature	nature	NOUN
ijpds-4639	251	2	.	.	PUNCT
ijpds-4639	252	1	1996	1996	NUM
ijpds-4639	252	2	;	;	PUNCT
ijpds-4639	252	3	379(6566):632	379(6566):632	NUM
ijpds-4639	252	4	-	-	SYM
ijpds-4639	252	5	5	5	NUM
ijpds-4639	252	6	.	.	PUNCT
ijpds-4639	253	1	doi:10.1038/379632a0	doi:10.1038/379632a0	PROPN
ijpds-4639	253	2	17	17	NUM
ijpds-4639	253	3	.	.	PUNCT
ijpds-4639	254	1	vaisse	vaisse	PROPN
ijpds-4639	254	2	c	c	PROPN
ijpds-4639	254	3	,	,	PUNCT
ijpds-4639	254	4	halaas	halaas	PROPN
ijpds-4639	254	5	jl	jl	PROPN
ijpds-4639	254	6	,	,	PUNCT
ijpds-4639	254	7	horvath	horvath	PROPN
ijpds-4639	254	8	cm	cm	PROPN
ijpds-4639	254	9	,	,	PUNCT
ijpds-4639	254	10	et	et	PROPN
ijpds-4639	254	11	al	al	PROPN
ijpds-4639	254	12	.	.	PROPN
ijpds-4639	254	13	leptin	leptin	NOUN
ijpds-4639	254	14	activation	activation	NOUN
ijpds-4639	254	15	of	of	ADP
ijpds-4639	254	16	stat3	stat3	NOUN
ijpds-4639	254	17	in	in	ADP
ijpds-4639	254	18	the	the	DET
ijpds-4639	254	19	hypothalamus	hypothalamus	NOUN
ijpds-4639	254	20	of	of	ADP
ijpds-4639	254	21	wild	wild	ADJ
ijpds-4639	254	22	–	–	PUNCT
ijpds-4639	254	23	type	type	NOUN
ijpds-4639	254	24	and	and	CCONJ
ijpds-4639	254	25	ob	ob	NOUN
ijpds-4639	254	26	/	/	SYM
ijpds-4639	254	27	ob	ob	VERB
ijpds-4639	254	28	mice	mouse	NOUN
ijpds-4639	254	29	but	but	CCONJ
ijpds-4639	254	30	not	not	PART
ijpds-4639	254	31	db	db	PROPN
ijpds-4639	254	32	/	/	SYM
ijpds-4639	254	33	db	db	NOUN
ijpds-4639	254	34	mice	mouse	NOUN
ijpds-4639	254	35	.	.	PUNCT
ijpds-4639	255	1	nature	nature	NOUN
ijpds-4639	255	2	genetics	genetic	NOUN
ijpds-4639	255	3	.	.	PUNCT
ijpds-4639	256	1	1996	1996	NUM
ijpds-4639	256	2	;	;	PUNCT
ijpds-4639	256	3	14(1):95	14(1):95	NUM
ijpds-4639	256	4	-	-	SYM
ijpds-4639	256	5	7	7	NUM
ijpds-4639	256	6	.	.	PUNCT
ijpds-4639	256	7	doi	doi	NOUN
ijpds-4639	256	8	:	:	PUNCT
ijpds-4639	256	9	10.1038	10.1038	NUM
ijpds-4639	256	10	/	/	SYM
ijpds-4639	256	11	ng0996	ng0996	PROPN
ijpds-4639	257	1	95	95	NUM
ijpds-4639	257	2	18	18	NUM
ijpds-4639	257	3	.	.	PUNCT
ijpds-4639	258	1	dallner	dallner	PROPN
ijpds-4639	258	2	os	os	PROPN
ijpds-4639	258	3	,	,	PUNCT
ijpds-4639	258	4	marinis	marinis	PROPN
ijpds-4639	258	5	jm	jm	PROPN
ijpds-4639	258	6	,	,	PUNCT
ijpds-4639	258	7	lu	lu	PROPN
ijpds-4639	258	8	yh	yh	PROPN
ijpds-4639	258	9	,	,	PUNCT
ijpds-4639	258	10	et	et	PROPN
ijpds-4639	258	11	al	al	PROPN
ijpds-4639	258	12	.	.	PROPN
ijpds-4639	258	13	dysregulation	dysregulation	NOUN
ijpds-4639	258	14	of	of	ADP
ijpds-4639	258	15	a	a	DET
ijpds-4639	258	16	long	long	ADJ
ijpds-4639	258	17	noncoding	noncoding	NOUN
ijpds-4639	258	18	rna	rna	NOUN
ijpds-4639	258	19	reduces	reduce	VERB
ijpds-4639	258	20	leptin	leptin	NOUN
ijpds-4639	258	21	leading	lead	VERB
ijpds-4639	258	22	to	to	ADP
ijpds-4639	258	23	a	a	DET
ijpds-4639	258	24	leptin	leptin	NOUN
ijpds-4639	258	25	-	-	PUNCT
ijpds-4639	258	26	responsive	responsive	ADJ
ijpds-4639	258	27	form	form	NOUN
ijpds-4639	258	28	of	of	ADP
ijpds-4639	258	29	obesity	obesity	NOUN
ijpds-4639	258	30	.	.	PUNCT
ijpds-4639	259	1	nature	nature	NOUN
ijpds-4639	259	2	medicine	medicine	NOUN
ijpds-4639	259	3	.	.	PUNCT
ijpds-4639	260	1	2019	2019	NUM
ijpds-4639	260	2	;	;	PUNCT
ijpds-4639	260	3	25(3):507	25(3):507	NUM
ijpds-4639	260	4	-	-	SYM
ijpds-4639	260	5	16	16	NUM
ijpds-4639	260	6	.	.	PUNCT
ijpds-4639	261	1	doi	doi	NOUN
ijpds-4639	261	2	:	:	PUNCT
ijpds-4639	261	3	10.1038	10.1038	NUM
ijpds-4639	261	4	/	/	SYM
ijpds-4639	261	5	s41591	s41591	VERB
ijpds-4639	261	6	-	-	PUNCT
ijpds-4639	261	7	019	019	NUM
ijpds-4639	261	8	-	-	PUNCT
ijpds-4639	261	9	0370	0370	NUM
ijpds-4639	261	10	-	-	SYM
ijpds-4639	261	11	1	1	NUM
ijpds-4639	261	12	19	19	NUM
ijpds-4639	261	13	.	.	PUNCT
ijpds-4639	262	1	mattace	mattace	PROPN
ijpds-4639	262	2	raso	raso	VERB
ijpds-4639	262	3	g	g	PROPN
ijpds-4639	262	4	,	,	PUNCT
ijpds-4639	263	1	santoro	santoro	PROPN
ijpds-4639	263	2	a	a	PRON
ijpds-4639	263	3	,	,	PUNCT
ijpds-4639	263	4	russo	russo	ADJ
ijpds-4639	263	5	r	r	NOUN
ijpds-4639	263	6	,	,	PUNCT
ijpds-4639	263	7	et	et	PROPN
ijpds-4639	263	8	al	al	PROPN
ijpds-4639	263	9	.	.	PROPN
ijpds-4639	263	10	palmitoylethanolamide	palmitoylethanolamide	PROPN
ijpds-4639	263	11	prevents	prevent	VERB
ijpds-4639	263	12	metabolic	metabolic	NOUN
ijpds-4639	263	13	alterations	alteration	NOUN
ijpds-4639	263	14	and	and	CCONJ
ijpds-4639	263	15	restores	restore	VERB
ijpds-4639	263	16	leptin	leptin	NOUN
ijpds-4639	263	17	sensitivity	sensitivity	NOUN
ijpds-4639	263	18	in	in	ADP
ijpds-4639	263	19	ovariectomized	ovariectomize	VERB
ijpds-4639	263	20	rats	rat	NOUN
ijpds-4639	263	21	.	.	PUNCT
ijpds-4639	264	1	endocrinology	endocrinology	NOUN
ijpds-4639	264	2	.	.	PUNCT
ijpds-4639	265	1	2014	2014	NUM
ijpds-4639	265	2	;	;	PUNCT
ijpds-4639	265	3	155(4):1291	155(4):1291	PROPN
ijpds-4639	265	4	-	-	PUNCT
ijpds-4639	265	5	301	301	NUM
ijpds-4639	265	6	.	.	PUNCT
ijpds-4639	266	1	doi:10.1210	doi:10.1210	PROPN
ijpds-4639	266	2	/	/	SYM
ijpds-4639	266	3	en.2013	en.2013	VERB
ijpds-4639	266	4	-	-	PUNCT
ijpds-4639	266	5	1823	1823	NUM
ijpds-4639	266	6	20	20	NUM
ijpds-4639	266	7	.	.	PUNCT
ijpds-4639	267	1	münzberg	münzberg	PROPN
ijpds-4639	267	2	h	h	PROPN
ijpds-4639	267	3	,	,	PUNCT
ijpds-4639	267	4	myers	myers	PROPN
ijpds-4639	267	5	jr	jr	PROPN
ijpds-4639	267	6	mg	mg	PROPN
ijpds-4639	267	7	.	.	PUNCT
ijpds-4639	268	1	molecular	molecular	ADJ
ijpds-4639	268	2	and	and	CCONJ
ijpds-4639	268	3	anatomical	anatomical	ADJ
ijpds-4639	268	4	determinants	determinant	NOUN
ijpds-4639	268	5	of	of	ADP
ijpds-4639	268	6	central	central	ADJ
ijpds-4639	268	7	leptin	leptin	NOUN
ijpds-4639	268	8	resistance	resistance	NOUN
ijpds-4639	268	9	.	.	PUNCT
ijpds-4639	269	1	nature	nature	NOUN
ijpds-4639	269	2	neuroscience	neuroscience	NOUN
ijpds-4639	269	3	.	.	PUNCT
ijpds-4639	270	1	2005	2005	NUM
ijpds-4639	270	2	;	;	PUNCT
ijpds-4639	270	3	8(5):566	8(5):566	NUM
ijpds-4639	270	4	-	-	SYM
ijpds-4639	270	5	70	70	NUM
ijpds-4639	270	6	.	.	PUNCT
ijpds-4639	271	1	doi:10.1038	doi:10.1038	NOUN
ijpds-4639	271	2	/	/	SYM
ijpds-4639	271	3	nn1454	nn1454	PROPN
ijpds-4639	271	4	21	21	NUM
ijpds-4639	271	5	.	.	PUNCT
ijpds-4639	272	1	caro	caro	PROPN
ijpds-4639	272	2	jf	jf	PROPN
ijpds-4639	272	3	,	,	PUNCT
ijpds-4639	272	4	kolaczynski	kolaczynski	PROPN
ijpds-4639	272	5	jw	jw	PROPN
ijpds-4639	272	6	,	,	PUNCT
ijpds-4639	272	7	nyce	nyce	PROPN
ijpds-4639	272	8	mr	mr	PROPN
ijpds-4639	272	9	,	,	PUNCT
ijpds-4639	272	10	et	et	PROPN
ijpds-4639	272	11	al	al	PROPN
ijpds-4639	272	12	.	.	PROPN
ijpds-4639	272	13	decreased	decrease	VERB
ijpds-4639	272	14	cerebrospinal	cerebrospinal	ADJ
ijpds-4639	272	15	-	-	PUNCT
ijpds-4639	272	16	fluid	fluid	NOUN
ijpds-4639	272	17	/	/	SYM
ijpds-4639	272	18	serum	serum	NOUN
ijpds-4639	272	19	leptin	leptin	NOUN
ijpds-4639	272	20	ratio	ratio	NOUN
ijpds-4639	272	21	in	in	ADP
ijpds-4639	272	22	obesity	obesity	NOUN
ijpds-4639	272	23	:	:	PUNCT
ijpds-4639	272	24	a	a	DET
ijpds-4639	272	25	possible	possible	ADJ
ijpds-4639	272	26	mechanism	mechanism	NOUN
ijpds-4639	272	27	for	for	ADP
ijpds-4639	272	28	leptin	leptin	NOUN
ijpds-4639	272	29	resistance	resistance	NOUN
ijpds-4639	272	30	.	.	PUNCT
ijpds-4639	273	1	the	the	DET
ijpds-4639	273	2	lancet	lancet	NOUN
ijpds-4639	273	3	.	.	PUNCT
ijpds-4639	274	1	1996	1996	NUM
ijpds-4639	274	2	;	;	PUNCT
ijpds-4639	275	1	348(9021):159	348(9021):159	PROPN
ijpds-4639	275	2	-	-	SYM
ijpds-4639	275	3	61	61	NUM
ijpds-4639	275	4	.	.	PUNCT
ijpds-4639	276	1	doi	doi	NOUN
ijpds-4639	276	2	:	:	PUNCT
ijpds-4639	276	3	10.1016	10.1016	NUM
ijpds-4639	276	4	/	/	SYM
ijpds-4639	276	5	s0140	s0140	PROPN
ijpds-4639	276	6	-	-	PUNCT
ijpds-4639	276	7	6736(96)03173	6736(96)03173	NOUN
ijpds-4639	276	8	-	-	PUNCT
ijpds-4639	276	9	x	x	SYM
ijpds-4639	276	10	22	22	NUM
ijpds-4639	276	11	.	.	PUNCT
ijpds-4639	277	1	celik	celik	PROPN
ijpds-4639	277	2	o	o	NOUN
ijpds-4639	277	3	,	,	PUNCT
ijpds-4639	277	4	hascalik	hascalik	PROPN
ijpds-4639	277	5	s	s	PART
ijpds-4639	277	6	,	,	PUNCT
ijpds-4639	277	7	ozerol	ozerol	PROPN
ijpds-4639	277	8	e	e	NOUN
ijpds-4639	277	9	,	,	PUNCT
ijpds-4639	277	10	et	et	PROPN
ijpds-4639	277	11	al	al	PROPN
ijpds-4639	277	12	.	.	PUNCT
ijpds-4639	277	13	cerebrospinal	cerebrospinal	ADJ
ijpds-4639	277	14	fluid	fluid	ADJ
ijpds-4639	277	15	leptin	leptin	NOUN
ijpds-4639	277	16	levels	level	NOUN
ijpds-4639	277	17	in	in	ADP
ijpds-4639	277	18	preeclampsia	preeclampsia	NOUN
ijpds-4639	277	19	:	:	PUNCT
ijpds-4639	277	20	relation	relation	NOUN
ijpds-4639	277	21	to	to	ADP
ijpds-4639	277	22	maternal	maternal	ADJ
ijpds-4639	277	23	serum	serum	NOUN
ijpds-4639	277	24	leptin	leptin	NOUN
ijpds-4639	277	25	levels	level	NOUN
ijpds-4639	277	26	.	.	PUNCT
ijpds-4639	278	1	acta	acta	PROPN
ijpds-4639	278	2	obstetricia	obstetricia	PROPN
ijpds-4639	278	3	et	et	PROPN
ijpds-4639	278	4	gynecologica	gynecologica	PROPN
ijpds-4639	278	5	scandinavica	scandinavica	PROPN
ijpds-4639	278	6	.	.	PUNCT
ijpds-4639	279	1	2004	2004	NUM
ijpds-4639	279	2	;	;	PUNCT
ijpds-4639	279	3	83(6):51923	83(6):51923	NUM
ijpds-4639	279	4	.	.	PUNCT
ijpds-4639	280	1	doi:10.1080	doi:10.1080	NOUN
ijpds-4639	280	2	/	/	PUNCT
ijpds-4639	280	3	j.0001	j.0001	NOUN
ijpds-4639	280	4	-	-	PUNCT
ijpds-4639	280	5	6349.2004.00325.x	6349.2004.00325.x	NUM
ijpds-4639	280	6	23	23	NUM
ijpds-4639	280	7	.	.	PUNCT
ijpds-4639	281	1	coppari	coppari	PROPN
ijpds-4639	281	2	r	r	NOUN
ijpds-4639	281	3	,	,	PUNCT
ijpds-4639	281	4	bjørbæk	bjørbæk	PROPN
ijpds-4639	281	5	c.	c.	PROPN
ijpds-4639	281	6	leptin	leptin	PROPN
ijpds-4639	281	7	revisited	revisit	VERB
ijpds-4639	281	8	:	:	PUNCT
ijpds-4639	281	9	its	its	PRON
ijpds-4639	281	10	mechanism	mechanism	NOUN
ijpds-4639	281	11	of	of	ADP
ijpds-4639	281	12	action	action	NOUN
ijpds-4639	281	13	and	and	CCONJ
ijpds-4639	281	14	potential	potential	NOUN
ijpds-4639	281	15	for	for	ADP
ijpds-4639	281	16	treating	treat	VERB
ijpds-4639	281	17	diabetes	diabetes	NOUN
ijpds-4639	281	18	.	.	PUNCT
ijpds-4639	282	1	nature	nature	NOUN
ijpds-4639	282	2	reviews	review	VERB
ijpds-4639	282	3	drug	drug	NOUN
ijpds-4639	282	4	discovery	discovery	NOUN
ijpds-4639	282	5	.	.	PUNCT
ijpds-4639	283	1	2012	2012	NUM
ijpds-4639	283	2	;	;	PUNCT
ijpds-4639	283	3	11(9):692	11(9):692	NUM
ijpds-4639	283	4	-	-	SYM
ijpds-4639	283	5	708	708	NUM
ijpds-4639	283	6	.	.	PUNCT
ijpds-4639	283	7	doi:10.1038	doi:10.1038	NOUN
ijpds-4639	283	8	/	/	SYM
ijpds-4639	283	9	nrd3757	nrd3757	PROPN
ijpds-4639	283	10	24	24	NUM
ijpds-4639	283	11	.	.	PUNCT
ijpds-4639	284	1	bjørbæk	bjørbæk	PROPN
ijpds-4639	284	2	c	c	X
ijpds-4639	284	3	,	,	PUNCT
ijpds-4639	284	4	elmquist	elmquist	PROPN
ijpds-4639	284	5	jk	jk	PROPN
ijpds-4639	284	6	,	,	PUNCT
ijpds-4639	284	7	michl	michl	VERB
ijpds-4639	284	8	p	p	X
ijpds-4639	284	9	,	,	PUNCT
ijpds-4639	284	10	et	et	PROPN
ijpds-4639	284	11	al	al	PROPN
ijpds-4639	284	12	.	.	PUNCT
ijpds-4639	284	13	expression	expression	NOUN
ijpds-4639	284	14	of	of	ADP
ijpds-4639	284	15	leptin	leptin	NOUN
ijpds-4639	284	16	receptor	receptor	NOUN
ijpds-4639	284	17	isoforms	isoform	NOUN
ijpds-4639	284	18	in	in	ADP
ijpds-4639	284	19	rat	rat	NOUN
ijpds-4639	284	20	brain	brain	NOUN
ijpds-4639	284	21	microvessels	microvessel	NOUN
ijpds-4639	284	22	.	.	PUNCT
ijpds-4639	285	1	endocrinology	endocrinology	NOUN
ijpds-4639	285	2	.	.	PUNCT
ijpds-4639	286	1	1998	1998	NUM
ijpds-4639	286	2	;	;	PUNCT
ijpds-4639	286	3	139(8):3485	139(8):3485	PROPN
ijpds-4639	286	4	-	-	SYM
ijpds-4639	286	5	91	91	NUM
ijpds-4639	286	6	.	.	PUNCT
ijpds-4639	287	1	doi:10.1210	doi:10.1210	PROPN
ijpds-4639	287	2	/	/	SYM
ijpds-4639	287	3	endo.139.8.6154	endo.139.8.6154	NOUN
ijpds-4639	287	4	25	25	NUM
ijpds-4639	287	5	.	.	PUNCT
ijpds-4639	288	1	zabolotny	zabolotny	PROPN
ijpds-4639	288	2	jm	jm	PROPN
ijpds-4639	288	3	,	,	PUNCT
ijpds-4639	288	4	bence	bence	NOUN
ijpds-4639	288	5	-	-	PUNCT
ijpds-4639	288	6	hanulec	hanulec	NOUN
ijpds-4639	288	7	kk	kk	PROPN
ijpds-4639	288	8	,	,	PUNCT
ijpds-4639	288	9	stricker	stricker	PROPN
ijpds-4639	288	10	-	-	PUNCT
ijpds-4639	288	11	krongrad	krongrad	PROPN
ijpds-4639	288	12	a	a	PROPN
ijpds-4639	288	13	,	,	PUNCT
ijpds-4639	288	14	et	et	PROPN
ijpds-4639	288	15	al	al	PROPN
ijpds-4639	288	16	.	.	PUNCT
ijpds-4639	288	17	ptp1b	ptp1b	PROPN
ijpds-4639	288	18	regulates	regulate	VERB
ijpds-4639	288	19	leptin	leptin	NOUN
ijpds-4639	288	20	signal	signal	PROPN
ijpds-4639	288	21	transduction	transduction	NOUN
ijpds-4639	288	22	in	in	ADP
ijpds-4639	288	23	vivo	vivo	NOUN
ijpds-4639	288	24	.	.	PUNCT
ijpds-4639	289	1	developmental	developmental	ADJ
ijpds-4639	289	2	cell	cell	NOUN
ijpds-4639	289	3	.	.	PUNCT
ijpds-4639	290	1	2002	2002	NUM
ijpds-4639	290	2	apr	apr	PROPN
ijpds-4639	290	3	1;2(4):489	1;2(4):489	NUM
ijpds-4639	290	4	-	-	PUNCT
ijpds-4639	290	5	95	95	NUM
ijpds-4639	290	6	.	.	PUNCT
ijpds-4639	291	1	doi	doi	NOUN
ijpds-4639	291	2	:	:	PUNCT
ijpds-4639	291	3	10.1016	10.1016	NUM
ijpds-4639	291	4	/	/	SYM
ijpds-4639	291	5	s1534	s1534	NOUN
ijpds-4639	291	6	-	-	PUNCT
ijpds-4639	291	7	5807(02)00148	5807(02)00148	NOUN
ijpds-4639	291	8	-	-	PUNCT
ijpds-4639	291	9	x	x	SYM
ijpds-4639	291	10	26	26	NUM
ijpds-4639	291	11	.	.	PUNCT
ijpds-4639	292	1	liao	liao	PROPN
ijpds-4639	292	2	gy	gy	PROPN
ijpds-4639	292	3	,	,	PUNCT
ijpds-4639	292	4	an	an	DET
ijpds-4639	292	5	jj	jj	PROPN
ijpds-4639	292	6	,	,	PUNCT
ijpds-4639	292	7	gharami	gharami	NOUN
ijpds-4639	292	8	k	k	PROPN
ijpds-4639	292	9	,	,	PUNCT
ijpds-4639	292	10	et	et	PROPN
ijpds-4639	292	11	al	al	PROPN
ijpds-4639	292	12	.	.	PROPN
ijpds-4639	292	13	dendritically	dendritically	ADV
ijpds-4639	292	14	targeted	target	VERB
ijpds-4639	292	15	bdnf	bdnf	PROPN
ijpds-4639	292	16	mrna	mrna	PROPN
ijpds-4639	292	17	is	be	AUX
ijpds-4639	292	18	essential	essential	ADJ
ijpds-4639	292	19	for	for	SCONJ
ijpds-4639	292	20	energy	energy	NOUN
ijpds-4639	292	21	balance	balance	NOUN
ijpds-4639	292	22	and	and	CCONJ
ijpds-4639	292	23	response	response	NOUN
ijpds-4639	292	24	to	to	PART
ijpds-4639	292	25	leptin	leptin	VERB
ijpds-4639	292	26	.	.	PUNCT
ijpds-4639	293	1	nature	nature	NOUN
ijpds-4639	293	2	medicine	medicine	NOUN
ijpds-4639	293	3	.	.	PUNCT
ijpds-4639	294	1	2012	2012	NUM
ijpds-4639	294	2	apr;18(4):564	apr;18(4):564	PROPN
ijpds-4639	294	3	-	-	SYM
ijpds-4639	294	4	71	71	NUM
ijpds-4639	294	5	.	.	PUNCT
ijpds-4639	295	1	doi:10.1038	doi:10.1038	NOUN
ijpds-4639	295	2	/	/	SYM
ijpds-4639	295	3	nm.2687	nm.2687	PROPN
ijpds-4639	295	4	27	27	NUM
ijpds-4639	295	5	.	.	PUNCT
ijpds-4639	296	1	shaodong	shaodong	PROPN
ijpds-4639	296	2	c	c	PROPN
ijpds-4639	296	3	,	,	PUNCT
ijpds-4639	296	4	haihong	haihong	PROPN
ijpds-4639	296	5	z	z	PROPN
ijpds-4639	296	6	,	,	PUNCT
ijpds-4639	296	7	manting	mante	VERB
ijpds-4639	296	8	l	l	NOUN
ijpds-4639	296	9	,	,	PUNCT
ijpds-4639	296	10	et	et	PROPN
ijpds-4639	296	11	al	al	PROPN
ijpds-4639	296	12	.	.	PUNCT
ijpds-4639	296	13	research	research	NOUN
ijpds-4639	296	14	of	of	ADP
ijpds-4639	296	15	influence	influence	NOUN
ijpds-4639	296	16	and	and	CCONJ
ijpds-4639	296	17	mechanism	mechanism	NOUN
ijpds-4639	296	18	of	of	ADP
ijpds-4639	296	19	combining	combine	VERB
ijpds-4639	296	20	exercise	exercise	NOUN
ijpds-4639	296	21	with	with	ADP
ijpds-4639	296	22	diet	diet	NOUN
ijpds-4639	296	23	control	control	NOUN
ijpds-4639	296	24	on	on	ADP
ijpds-4639	296	25	a	a	DET
ijpds-4639	296	26	model	model	NOUN
ijpds-4639	296	27	of	of	ADP
ijpds-4639	296	28	lipid	lipid	ADJ
ijpds-4639	296	29	metabolism	metabolism	NOUN
ijpds-4639	296	30	rat	rat	NOUN
ijpds-4639	296	31	induced	induce	VERB
ijpds-4639	296	32	by	by	ADP
ijpds-4639	296	33	high	high	ADJ
ijpds-4639	296	34	fat	fat	ADJ
ijpds-4639	296	35	diet	diet	NOUN
ijpds-4639	296	36	.	.	PUNCT
ijpds-4639	297	1	lipids	lipid	NOUN
ijpds-4639	297	2	in	in	ADP
ijpds-4639	297	3	health	health	NOUN
ijpds-4639	297	4	and	and	CCONJ
ijpds-4639	297	5	disease	disease	NOUN
ijpds-4639	297	6	.	.	PUNCT
ijpds-4639	298	1	2013	2013	NUM
ijpds-4639	298	2	;	;	PUNCT
ijpds-4639	298	3	12:1	12:1	NUM
ijpds-4639	298	4	-	-	SYM
ijpds-4639	298	5	4	4	NUM
ijpds-4639	298	6	.	.	PUNCT
ijpds-4639	298	7	doi:10.1186/1476	doi:10.1186/1476	ADJ
ijpds-4639	298	8	-	-	PUNCT
ijpds-4639	298	9	511x-12	511x-12	NOUN
ijpds-4639	298	10	-	-	PUNCT
ijpds-4639	298	11	21	21	NUM
ijpds-4639	298	12	28	28	NUM
ijpds-4639	298	13	.	.	PUNCT
ijpds-4639	299	1	peng	peng	PROPN
ijpds-4639	299	2	j	j	PROPN
ijpds-4639	299	3	,	,	PUNCT
ijpds-4639	299	4	yin	yin	PROPN
ijpds-4639	299	5	l	l	PROPN
ijpds-4639	299	6	,	,	PUNCT
ijpds-4639	299	7	wang	wang	PROPN
ijpds-4639	299	8	x.	x.	PROPN
ijpds-4639	299	9	central	central	ADJ
ijpds-4639	299	10	and	and	CCONJ
ijpds-4639	299	11	peripheral	peripheral	ADJ
ijpds-4639	299	12	leptin	leptin	NOUN
ijpds-4639	299	13	resistance	resistance	NOUN
ijpds-4639	299	14	in	in	ADP
ijpds-4639	299	15	obesity	obesity	NOUN
ijpds-4639	299	16	and	and	CCONJ
ijpds-4639	299	17	improvements	improvement	NOUN
ijpds-4639	299	18	of	of	ADP
ijpds-4639	299	19	exercise	exercise	NOUN
ijpds-4639	299	20	.	.	PUNCT
ijpds-4639	300	1	hormones	hormone	NOUN
ijpds-4639	300	2	and	and	CCONJ
ijpds-4639	300	3	behavior	behavior	NOUN
ijpds-4639	300	4	.	.	PUNCT
ijpds-4639	301	1	2021	2021	NUM
ijpds-4639	301	2	;	;	PUNCT
ijpds-4639	301	3	133:105006	133:105006	NUM
ijpds-4639	301	4	.	.	X
ijpds-4639	301	5	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	301	6	/	/	SYM
ijpds-4639	301	7	j.yhbeh.2021.105006	j.yhbeh.2021.105006	PROPN
ijpds-4639	301	8	29	29	NUM
ijpds-4639	301	9	.	.	PUNCT
ijpds-4639	302	1	bhattarai	bhattarai	PROPN
ijpds-4639	302	2	br	br	PROPN
ijpds-4639	302	3	,	,	PUNCT
ijpds-4639	302	4	kafle	kafle	PROPN
ijpds-4639	302	5	b	b	PROPN
ijpds-4639	302	6	,	,	PUNCT
ijpds-4639	302	7	hwang	hwang	PROPN
ijpds-4639	302	8	js	js	PROPN
ijpds-4639	302	9	,	,	PUNCT
ijpds-4639	302	10	et	et	PROPN
ijpds-4639	302	11	al	al	PROPN
ijpds-4639	302	12	.	.	PROPN
ijpds-4639	302	13	novel	novel	PROPN
ijpds-4639	302	14	thiazolidinedione	thiazolidinedione	ADJ
ijpds-4639	302	15	derivatives	derivative	NOUN
ijpds-4639	302	16	with	with	ADP
ijpds-4639	302	17	anti	anti	ADJ
ijpds-4639	302	18	-	-	ADJ
ijpds-4639	302	19	obesity	obesity	ADJ
ijpds-4639	302	20	effects	effect	NOUN
ijpds-4639	302	21	:	:	PUNCT
ijpds-4639	302	22	dual	dual	ADJ
ijpds-4639	302	23	action	action	NOUN
ijpds-4639	302	24	as	as	ADP
ijpds-4639	302	25	ptp1b	ptp1b	NOUN
ijpds-4639	302	26	inhibitors	inhibitor	NOUN
ijpds-4639	302	27	and	and	CCONJ
ijpds-4639	302	28	ppar	ppar	NOUN
ijpds-4639	302	29	-	-	PUNCT
ijpds-4639	302	30	γ	γ	NOUN
ijpds-4639	302	31	activators	activator	NOUN
ijpds-4639	302	32	.	.	PUNCT
ijpds-4639	303	1	bioorganic	bioorganic	PROPN
ijpds-4639	303	2	&	&	CCONJ
ijpds-4639	303	3	medicinal	medicinal	ADJ
ijpds-4639	303	4	chemistry	chemistry	NOUN
ijpds-4639	303	5	letters	letter	NOUN
ijpds-4639	303	6	.	.	PUNCT
ijpds-4639	304	1	2010	2010	NUM
ijpds-4639	304	2	;	;	PUNCT
ijpds-4639	304	3	20(22):6758	20(22):6758	NUM
ijpds-4639	304	4	-	-	SYM
ijpds-4639	304	5	63	63	NUM
ijpds-4639	304	6	.	.	PUNCT
ijpds-4639	304	7	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	304	8	/	/	SYM
ijpds-4639	304	9	j.bmcl.2010.08.130	j.bmcl.2010.08.130	PROPN
ijpds-4639	304	10	30	30	NUM
ijpds-4639	304	11	.	.	PUNCT
ijpds-4639	305	1	springer	springer	PROPN
ijpds-4639	305	2	am	am	NOUN
ijpds-4639	305	3	,	,	PUNCT
ijpds-4639	305	4	foster	foster	NOUN
ijpds-4639	305	5	-	-	PUNCT
ijpds-4639	305	6	schubert	schubert	PROPN
ijpds-4639	305	7	k	k	PROPN
ijpds-4639	305	8	,	,	PUNCT
ijpds-4639	305	9	morton	morton	PROPN
ijpds-4639	305	10	gj	gj	PROPN
ijpds-4639	305	11	,	,	PUNCT
ijpds-4639	305	12	et	et	PROPN
ijpds-4639	305	13	al	al	PROPN
ijpds-4639	305	14	.	.	PROPN
ijpds-4639	305	15	is	be	AUX
ijpds-4639	305	16	there	there	PRON
ijpds-4639	305	17	evidence	evidence	NOUN
ijpds-4639	305	18	that	that	SCONJ
ijpds-4639	305	19	estrogen	estrogen	NOUN
ijpds-4639	305	20	therapy	therapy	NOUN
ijpds-4639	305	21	promotes	promote	VERB
ijpds-4639	305	22	weight	weight	NOUN
ijpds-4639	305	23	maintenance	maintenance	NOUN
ijpds-4639	305	24	via	via	ADP
ijpds-4639	305	25	effects	effect	NOUN
ijpds-4639	305	26	on	on	ADP
ijpds-4639	305	27	leptin	leptin	NOUN
ijpds-4639	305	28	?	?	PUNCT
ijpds-4639	305	29	.	.	PUNCT
ijpds-4639	306	1	menopause	menopause	NOUN
ijpds-4639	306	2	.	.	PUNCT
ijpds-4639	307	1	2014	2014	NUM
ijpds-4639	307	2	;	;	PUNCT
ijpds-4639	307	3	21(4):424	21(4):424	NUM
ijpds-4639	307	4	-	-	SYM
ijpds-4639	307	5	32	32	NUM
ijpds-4639	307	6	.	.	PUNCT
ijpds-4639	308	1	doi:10.1097	doi:10.1097	PROPN
ijpds-4639	308	2	/	/	SYM
ijpds-4639	309	1	gme.0000000000000117	gme.0000000000000117	NUM
ijpds-4639	309	2	31	31	NUM
ijpds-4639	309	3	.	.	PUNCT
ijpds-4639	309	4	di	di	PROPN
ijpds-4639	309	5	carlo	carlo	PROPN
ijpds-4639	309	6	c	c	PROPN
ijpds-4639	309	7	,	,	PUNCT
ijpds-4639	309	8	tommaselli	tommaselli	PROPN
ijpds-4639	309	9	ga	ga	PROPN
ijpds-4639	309	10	,	,	PUNCT
ijpds-4639	309	11	pisano	pisano	PROPN
ijpds-4639	309	12	g	g	PROPN
ijpds-4639	309	13	,	,	PUNCT
ijpds-4639	309	14	et	et	PROPN
ijpds-4639	309	15	al	al	PROPN
ijpds-4639	309	16	.	.	PROPN
ijpds-4639	309	17	serum	serum	PROPN
ijpds-4639	309	18	leptin	leptin	NOUN
ijpds-4639	309	19	levels	level	NOUN
ijpds-4639	309	20	in	in	ADP
ijpds-4639	309	21	postmenopausal	postmenopausal	ADJ
ijpds-4639	309	22	women	woman	NOUN
ijpds-4639	309	23	:	:	PUNCT
ijpds-4639	309	24	effects	effect	NOUN
ijpds-4639	309	25	of	of	ADP
ijpds-4639	309	26	transdermal	transdermal	ADJ
ijpds-4639	309	27	hormone	hormone	NOUN
ijpds-4639	309	28	replacement	replacement	NOUN
ijpds-4639	309	29	therapy	therapy	NOUN
ijpds-4639	309	30	.	.	PUNCT
ijpds-4639	310	1	menopause	menopause	NOUN
ijpds-4639	310	2	.	.	PUNCT
ijpds-4639	311	1	2000	2000	NUM
ijpds-4639	311	2	;	;	PUNCT
ijpds-4639	312	1	7(1):36	7(1):36	NOUN
ijpds-4639	312	2	-	-	SYM
ijpds-4639	312	3	41	41	NUM
ijpds-4639	312	4	.	.	PUNCT
ijpds-4639	313	1	doi	doi	NOUN
ijpds-4639	313	2	:	:	PUNCT
ijpds-4639	313	3	10.1097/00042192	10.1097/00042192	NUM
ijpds-4639	313	4	-	-	PUNCT
ijpds-4639	313	5	200007010	200007010	NUM
ijpds-4639	313	6	-	-	SYM
ijpds-4639	313	7	00007	00007	NUM
ijpds-4639	313	8	32	32	NUM
ijpds-4639	313	9	.	.	PUNCT
ijpds-4639	314	1	di	di	PROPN
ijpds-4639	314	2	carlo	carlo	PROPN
ijpds-4639	314	3	c	c	PROPN
ijpds-4639	314	4	,	,	PUNCT
ijpds-4639	314	5	tommaselli	tommaselli	PROPN
ijpds-4639	314	6	ga	ga	PROPN
ijpds-4639	314	7	,	,	PUNCT
ijpds-4639	314	8	sammartino	sammartino	PROPN
ijpds-4639	314	9	a	a	X
ijpds-4639	314	10	,	,	PUNCT
ijpds-4639	314	11	et	et	PROPN
ijpds-4639	314	12	al	al	PROPN
ijpds-4639	314	13	.	.	PROPN
ijpds-4639	314	14	serum	serum	PROPN
ijpds-4639	314	15	leptin	leptin	NOUN
ijpds-4639	314	16	levels	level	NOUN
ijpds-4639	314	17	and	and	CCONJ
ijpds-4639	314	18	body	body	NOUN
ijpds-4639	314	19	composition	composition	NOUN
ijpds-4639	314	20	in	in	ADP
ijpds-4639	314	21	postmenopausal	postmenopausal	ADJ
ijpds-4639	314	22	women	woman	NOUN
ijpds-4639	314	23	:	:	PUNCT
ijpds-4639	314	24	effects	effect	NOUN
ijpds-4639	314	25	of	of	ADP
ijpds-4639	314	26	hormone	hormone	NOUN
ijpds-4639	314	27	therapy	therapy	NOUN
ijpds-4639	314	28	.	.	PUNCT
ijpds-4639	315	1	menopause	menopause	NOUN
ijpds-4639	315	2	.	.	PUNCT
ijpds-4639	316	1	2004	2004	NUM
ijpds-4639	316	2	;	;	PUNCT
ijpds-4639	317	1	11(4):466	11(4):466	NUM
ijpds-4639	317	2	-	-	SYM
ijpds-4639	317	3	73	73	NUM
ijpds-4639	317	4	.	.	PUNCT
ijpds-4639	318	1	doi	doi	NOUN
ijpds-4639	318	2	:	:	PUNCT
ijpds-4639	318	3	10.1097/01.gme.0000109313.11228.2b	10.1097/01.gme.0000109313.11228.2b	NUM
ijpds-4639	318	4	33	33	NUM
ijpds-4639	318	5	.	.	PUNCT
ijpds-4639	319	1	y	y	PROPN
ijpds-4639	319	2	̈	̈	PUNCT
ijpds-4639	319	3	ksel	ksel	PROPN
ijpds-4639	319	4	h	h	NOUN
ijpds-4639	319	5	,	,	PUNCT
ijpds-4639	319	6	odabaşi	odabaşi	PROPN
ijpds-4639	319	7	ar	ar	PROPN
ijpds-4639	319	8	,	,	PUNCT
ijpds-4639	319	9	demircan	demircan	PROPN
ijpds-4639	319	10	s	s	PROPN
ijpds-4639	319	11	,	,	PUNCT
ijpds-4639	319	12	et	et	PROPN
ijpds-4639	319	13	al	al	PROPN
ijpds-4639	319	14	.	.	PUNCT
ijpds-4639	319	15	effects	effect	NOUN
ijpds-4639	319	16	of	of	ADP
ijpds-4639	319	17	oral	oral	ADJ
ijpds-4639	319	18	continuous	continuous	ADJ
ijpds-4639	319	19	17β	17β	NOUN
ijpds-4639	319	20	-	-	PUNCT
ijpds-4639	319	21	estradiol	estradiol	PROPN
ijpds-4639	319	22	plus	plus	CCONJ
ijpds-4639	319	23	norethisterone	norethisterone	ADJ
ijpds-4639	319	24	acetate	acetate	NOUN
ijpds-4639	319	25	replacement	replacement	NOUN
ijpds-4639	319	26	therapy	therapy	NOUN
ijpds-4639	319	27	on	on	ADP
ijpds-4639	319	28	abdominal	abdominal	ADJ
ijpds-4639	319	29	subcutaneous	subcutaneous	ADJ
ijpds-4639	319	30	fat	fat	NOUN
ijpds-4639	319	31	,	,	PUNCT
ijpds-4639	319	32	serum	serum	NOUN
ijpds-4639	319	33	leptin	leptin	NOUN
ijpds-4639	319	34	levels	level	NOUN
ijpds-4639	319	35	and	and	CCONJ
ijpds-4639	319	36	body	body	NOUN
ijpds-4639	319	37	composition	composition	NOUN
ijpds-4639	319	38	.	.	PUNCT
ijpds-4639	320	1	gynecological	gynecological	ADJ
ijpds-4639	320	2	endocrinology	endocrinology	NOUN
ijpds-4639	320	3	.	.	PUNCT
ijpds-4639	321	1	2006	2006	NUM
ijpds-4639	321	2	;	;	PUNCT
ijpds-4639	321	3	22(7):381	22(7):381	NOUN
ijpds-4639	321	4	-	-	SYM
ijpds-4639	321	5	7	7	NUM
ijpds-4639	321	6	.	.	PUNCT
ijpds-4639	321	7	doi:10.1080/09513590600842281	doi:10.1080/09513590600842281	ADJ
ijpds-4639	321	8	34	34	NUM
ijpds-4639	321	9	.	.	PUNCT
ijpds-4639	322	1	konukoglu	konukoglu	PROPN
ijpds-4639	322	2	d	d	PROPN
ijpds-4639	322	3	,	,	PUNCT
ijpds-4639	322	4	serin	serin	NOUN
ijpds-4639	322	5	ö	ö	PROPN
ijpds-4639	322	6	,	,	PUNCT
ijpds-4639	322	7	ercan	ercan	PROPN
ijpds-4639	322	8	m.	m.	NOUN
ijpds-4639	322	9	plasma	plasma	PROPN
ijpds-4639	322	10	leptin	leptin	NOUN
ijpds-4639	322	11	levels	level	NOUN
ijpds-4639	322	12	in	in	ADP
ijpds-4639	322	13	obese	obese	ADJ
ijpds-4639	322	14	and	and	CCONJ
ijpds-4639	322	15	non	non	ADJ
ijpds-4639	322	16	-	-	ADJ
ijpds-4639	322	17	obese	obese	ADJ
ijpds-4639	322	18	postmenopausal	postmenopausal	ADJ
ijpds-4639	322	19	women	woman	NOUN
ijpds-4639	322	20	before	before	ADP
ijpds-4639	322	21	and	and	CCONJ
ijpds-4639	322	22	after	after	ADP
ijpds-4639	322	23	hormone	hormone	NOUN
ijpds-4639	322	24	replacement	replacement	NOUN
ijpds-4639	322	25	therapy	therapy	NOUN
ijpds-4639	322	26	.	.	PUNCT
ijpds-4639	323	1	maturitas	maturita	NOUN
ijpds-4639	323	2	.	.	PUNCT
ijpds-4639	324	1	2000	2000	NUM
ijpds-4639	324	2	;	;	PUNCT
ijpds-4639	325	1	36(3):203	36(3):203	NUM
ijpds-4639	325	2	-	-	SYM
ijpds-4639	325	3	7	7	NUM
ijpds-4639	325	4	.	.	PUNCT
ijpds-4639	325	5	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	325	6	/	/	SYM
ijpds-4639	325	7	s0378	s0378	PROPN
ijpds-4639	325	8	-	-	PUNCT
ijpds-4639	325	9	5122(00)00153	5122(00)00153	NUM
ijpds-4639	325	10	-	-	SYM
ijpds-4639	325	11	5	5	NUM
ijpds-4639	325	12	35	35	NUM
ijpds-4639	325	13	.	.	PUNCT
ijpds-4639	326	1	castelo	castelo	NOUN
ijpds-4639	326	2	-	-	PUNCT
ijpds-4639	326	3	branco	branco	PROPN
ijpds-4639	326	4	c	c	NOUN
ijpds-4639	326	5	,	,	PUNCT
ijpds-4639	326	6	palacios	palacio	NOUN
ijpds-4639	326	7	s	s	PROPN
ijpds-4639	326	8	,	,	PUNCT
ijpds-4639	326	9	vázquez	vázquez	NOUN
ijpds-4639	326	10	f	f	NOUN
ijpds-4639	326	11	,	,	PUNCT
ijpds-4639	326	12	et	et	PROPN
ijpds-4639	326	13	al	al	PROPN
ijpds-4639	326	14	.	.	PUNCT
ijpds-4639	326	15	effects	effect	NOUN
ijpds-4639	326	16	on	on	ADP
ijpds-4639	326	17	serum	serum	NOUN
ijpds-4639	326	18	lipid	lipid	NOUN
ijpds-4639	326	19	and	and	CCONJ
ijpds-4639	326	20	leptin	leptin	NOUN
ijpds-4639	326	21	levels	level	NOUN
ijpds-4639	326	22	of	of	ADP
ijpds-4639	326	23	three	three	NUM
ijpds-4639	326	24	different	different	ADJ
ijpds-4639	326	25	doses	dose	NOUN
ijpds-4639	326	26	of	of	ADP
ijpds-4639	326	27	norethisterone	norethisterone	NOUN
ijpds-4639	326	28	continuously	continuously	ADV
ijpds-4639	326	29	combined	combine	VERB
ijpds-4639	326	30	with	with	ADP
ijpds-4639	326	31	a	a	DET
ijpds-4639	326	32	fixed	fix	VERB
ijpds-4639	326	33	dose	dose	NOUN
ijpds-4639	326	34	of	of	ADP
ijpds-4639	326	35	17β	17β	PROPN
ijpds-4639	326	36	-	-	PUNCT
ijpds-4639	326	37	estradiol	estradiol	PROPN
ijpds-4639	326	38	for	for	ADP
ijpds-4639	326	39	nasal	nasal	PROPN
ijpds-4639	326	40	administration	administration	PROPN
ijpds-4639	326	41	in	in	ADP
ijpds-4639	326	42	postmenopausal	postmenopausal	ADJ
ijpds-4639	326	43	women	woman	NOUN
ijpds-4639	326	44	:	:	PUNCT
ijpds-4639	326	45	a	a	DET
ijpds-4639	326	46	controlled	control	VERB
ijpds-4639	326	47	,	,	PUNCT
ijpds-4639	326	48	double	double	ADJ
ijpds-4639	326	49	-	-	PUNCT
ijpds-4639	326	50	blind	blind	ADJ
ijpds-4639	326	51	study	study	NOUN
ijpds-4639	326	52	.	.	PUNCT
ijpds-4639	327	1	fertility	fertility	NOUN
ijpds-4639	327	2	and	and	CCONJ
ijpds-4639	327	3	sterility	sterility	NOUN
ijpds-4639	327	4	.	.	PUNCT
ijpds-4639	328	1	2007	2007	NUM
ijpds-4639	328	2	;	;	PUNCT
ijpds-4639	328	3	88(2):383	88(2):383	NUM
ijpds-4639	328	4	-	-	SYM
ijpds-4639	328	5	9	9	NUM
ijpds-4639	328	6	.	.	PUNCT
ijpds-4639	329	1	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	329	2	/	/	SYM
ijpds-4639	329	3	j.fertnstert.2006.11.142	j.fertnstert.2006.11.142	PROPN
ijpds-4639	329	4	36	36	NUM
ijpds-4639	329	5	.	.	PUNCT
ijpds-4639	330	1	aubert	aubert	PROPN
ijpds-4639	330	2	g	g	PROPN
ijpds-4639	330	3	,	,	PUNCT
ijpds-4639	330	4	mansuy	mansuy	PROPN
ijpds-4639	330	5	v	v	NOUN
ijpds-4639	330	6	,	,	PUNCT
ijpds-4639	330	7	voirol	voirol	PROPN
ijpds-4639	330	8	mj	mj	PROPN
ijpds-4639	330	9	,	,	PUNCT
ijpds-4639	330	10	et	et	PROPN
ijpds-4639	330	11	al	al	PROPN
ijpds-4639	330	12	.	.	PUNCT
ijpds-4639	331	1	the	the	DET
ijpds-4639	331	2	anorexigenic	anorexigenic	ADJ
ijpds-4639	331	3	effects	effect	NOUN
ijpds-4639	331	4	of	of	ADP
ijpds-4639	331	5	metformin	metformin	NOUN
ijpds-4639	331	6	involve	involve	VERB
ijpds-4639	331	7	increases	increase	NOUN
ijpds-4639	331	8	in	in	ADP
ijpds-4639	331	9	hypothalamic	hypothalamic	ADJ
ijpds-4639	331	10	leptin	leptin	NOUN
ijpds-4639	331	11	receptor	receptor	NOUN
ijpds-4639	331	12	expression	expression	NOUN
ijpds-4639	331	13	.	.	PUNCT
ijpds-4639	332	1	metabolism	metabolism	NOUN
ijpds-4639	332	2	.	.	PUNCT
ijpds-4639	333	1	2011	2011	NUM
ijpds-4639	333	2	;	;	PUNCT
ijpds-4639	333	3	60(3):327	60(3):327	NUM
ijpds-4639	333	4	-	-	SYM
ijpds-4639	333	5	34	34	NUM
ijpds-4639	333	6	.	.	PUNCT
ijpds-4639	333	7	doi:10.1016	doi:10.1016	PROPN
ijpds-4639	333	8	/	/	SYM
ijpds-4639	333	9	j.metabol.2010.02.007	j.metabol.2010.02.007	PROPN
ijpds-4639	333	10	37	37	NUM
ijpds-4639	333	11	.	.	PUNCT
ijpds-4639	334	1	tam	tam	PROPN
ijpds-4639	334	2	j	j	PROPN
ijpds-4639	334	3	,	,	PUNCT
ijpds-4639	334	4	cinar	cinar	PROPN
ijpds-4639	334	5	r	r	PROPN
ijpds-4639	334	6	,	,	PUNCT
ijpds-4639	334	7	liu	liu	PROPN
ijpds-4639	334	8	j	j	PROPN
ijpds-4639	334	9	,	,	PUNCT
ijpds-4639	334	10	et	et	PROPN
ijpds-4639	334	11	al	al	PROPN
ijpds-4639	334	12	.	.	PUNCT
ijpds-4639	335	1	peripheral	peripheral	ADJ
ijpds-4639	335	2	cannabinoid-1	cannabinoid-1	NUM
ijpds-4639	336	1	receptor	receptor	NOUN
ijpds-4639	336	2	inverse	inverse	NOUN
ijpds-4639	336	3	agonism	agonism	NOUN
ijpds-4639	336	4	reduces	reduce	VERB
ijpds-4639	336	5	obesity	obesity	NOUN
ijpds-4639	336	6	by	by	ADP
ijpds-4639	336	7	reversing	reverse	VERB
ijpds-4639	336	8	leptin	leptin	NOUN
ijpds-4639	336	9	resistance	resistance	NOUN
ijpds-4639	336	10	.	.	PUNCT
ijpds-4639	337	1	cell	cell	NOUN
ijpds-4639	337	2	metabolism	metabolism	NOUN
ijpds-4639	337	3	.	.	PUNCT
ijpds-4639	338	1	2012	2012	NUM
ijpds-4639	338	2	;	;	PUNCT
ijpds-4639	339	1	16(2):167	16(2):167	NUM
ijpds-4639	339	2	-	-	SYM
ijpds-4639	339	3	79	79	NUM
ijpds-4639	339	4	.	.	PUNCT
ijpds-4639	340	1	doi	doi	NOUN
ijpds-4639	340	2	:	:	PUNCT
ijpds-4639	340	3	10.1016	10.1016	NUM
ijpds-4639	340	4	/	/	SYM
ijpds-4639	340	5	j.cmet.2012.07.002	j.cmet.2012.07.002	PROPN
ijpds-4639	340	6	38	38	NUM
ijpds-4639	340	7	.	.	PUNCT
ijpds-4639	341	1	baumann	baumann	PROPN
ijpds-4639	341	2	h	h	PROPN
ijpds-4639	341	3	,	,	PUNCT
ijpds-4639	341	4	morella	morella	PROPN
ijpds-4639	341	5	kk	kk	PROPN
ijpds-4639	341	6	,	,	PUNCT
ijpds-4639	341	7	white	white	PROPN
ijpds-4639	341	8	dw	dw	PROPN
ijpds-4639	341	9	,	,	PUNCT
ijpds-4639	341	10	et	et	PROPN
ijpds-4639	341	11	al	al	PROPN
ijpds-4639	341	12	.	.	PUNCT
ijpds-4639	342	1	the	the	DET
ijpds-4639	342	2	full	full	ADJ
ijpds-4639	342	3	-	-	PUNCT
ijpds-4639	342	4	length	length	NOUN
ijpds-4639	342	5	leptin	leptin	NOUN
ijpds-4639	342	6	receptor	receptor	NOUN
ijpds-4639	342	7	has	have	AUX
ijpds-4639	342	8	signaling	signal	VERB
ijpds-4639	342	9	capabilities	capability	NOUN
ijpds-4639	342	10	of	of	ADP
ijpds-4639	342	11	interleukin	interleukin	NOUN
ijpds-4639	342	12	6	6	NUM
ijpds-4639	342	13	-	-	PUNCT
ijpds-4639	342	14	type	type	NOUN
ijpds-4639	342	15	cytokine	cytokine	NOUN
ijpds-4639	342	16	receptors	receptor	NOUN
ijpds-4639	342	17	.	.	PUNCT
ijpds-4639	343	1	proceedings	proceeding	NOUN
ijpds-4639	343	2	of	of	ADP
ijpds-4639	343	3	the	the	DET
ijpds-4639	343	4	national	national	PROPN
ijpds-4639	343	5	academy	academy	PROPN
ijpds-4639	343	6	of	of	ADP
ijpds-4639	343	7	sciences	sciences	PROPN
ijpds-4639	343	8	.	.	PUNCT
ijpds-4639	343	9	1996	1996	NUM
ijpds-4639	343	10	;	;	PUNCT
ijpds-4639	343	11	93(16):8374	93(16):8374	NUM
ijpds-4639	343	12	-	-	SYM
ijpds-4639	343	13	8	8	NUM
ijpds-4639	343	14	.	.	PUNCT
ijpds-4639	344	1	doi:10.1073	doi:10.1073	NOUN
ijpds-4639	344	2	/	/	SYM
ijpds-4639	344	3	pnas.93.16.8374	pnas.93.16.8374	NOUN
ijpds-4639	344	4	39	39	NUM
ijpds-4639	344	5	.	.	PUNCT
ijpds-4639	345	1	ghilardi	ghilardi	PROPN
ijpds-4639	345	2	n	n	CCONJ
ijpds-4639	345	3	,	,	PUNCT
ijpds-4639	345	4	ziegler	ziegler	PROPN
ijpds-4639	345	5	s	s	PROPN
ijpds-4639	345	6	,	,	PUNCT
ijpds-4639	345	7	wiestner	wiestner	X
ijpds-4639	345	8	a	a	NOUN
ijpds-4639	345	9	,	,	PUNCT
ijpds-4639	345	10	et	et	PROPN
ijpds-4639	345	11	al	al	PROPN
ijpds-4639	345	12	.	.	PROPN
ijpds-4639	345	13	defective	defective	ADJ
ijpds-4639	345	14	stat	stat	NOUN
ijpds-4639	345	15	signaling	signal	VERB
ijpds-4639	345	16	by	by	ADP
ijpds-4639	345	17	the	the	DET
ijpds-4639	345	18	leptin	leptin	NOUN
ijpds-4639	345	19	receptor	receptor	NOUN
ijpds-4639	345	20	in	in	ADP
ijpds-4639	345	21	diabetic	diabetic	ADJ
ijpds-4639	345	22	mice	mouse	NOUN
ijpds-4639	345	23	.	.	PUNCT
ijpds-4639	346	1	proceedings	proceeding	NOUN
ijpds-4639	346	2	of	of	ADP
ijpds-4639	346	3	the	the	DET
ijpds-4639	346	4	national	national	PROPN
ijpds-4639	346	5	academy	academy	PROPN
ijpds-4639	346	6	of	of	ADP
ijpds-4639	346	7	sciences	sciences	PROPN
ijpds-4639	346	8	.	.	PUNCT
ijpds-4639	346	9	1996	1996	NUM
ijpds-4639	346	10	;	;	PUNCT
ijpds-4639	346	11	93(13):6231	93(13):6231	X
ijpds-4639	346	12	-	-	SYM
ijpds-4639	346	13	5	5	NUM
ijpds-4639	346	14	.	.	PUNCT
ijpds-4639	346	15	doi:10.1073	doi:10.1073	NOUN
ijpds-4639	346	16	/	/	SYM
ijpds-4639	346	17	pnas.93.13.6231	pnas.93.13.6231	PROPN
ijpds-4639	346	18	40	40	NUM
ijpds-4639	346	19	.	.	PUNCT
ijpds-4639	347	1	heinrich	heinrich	PROPN
ijpds-4639	347	2	pc	pc	PROPN
ijpds-4639	347	3	,	,	PUNCT
ijpds-4639	347	4	behrmann	behrmann	NOUN
ijpds-4639	347	5	i	i	PROPN
ijpds-4639	347	6	,	,	PUNCT
ijpds-4639	347	7	haan	haan	PROPN
ijpds-4639	347	8	s	s	PROPN
ijpds-4639	347	9	,	,	PUNCT
ijpds-4639	347	10	et	et	PROPN
ijpds-4639	347	11	al	al	PROPN
ijpds-4639	347	12	.	.	PUNCT
ijpds-4639	347	13	principles	principle	NOUN
ijpds-4639	347	14	of	of	ADP
ijpds-4639	347	15	interleukin	interleukin	NOUN
ijpds-4639	347	16	(	(	PUNCT
ijpds-4639	347	17	il)-6	il)-6	NUM
ijpds-4639	347	18	-	-	PUNCT
ijpds-4639	347	19	type	type	NOUN
ijpds-4639	347	20	cytokine	cytokine	NOUN
ijpds-4639	347	21	signalling	signal	VERB
ijpds-4639	347	22	and	and	CCONJ
ijpds-4639	347	23	its	its	PRON
ijpds-4639	347	24	regulation	regulation	NOUN
ijpds-4639	347	25	.	.	PUNCT
ijpds-4639	348	1	biochemical	biochemical	ADJ
ijpds-4639	348	2	journal	journal	NOUN
ijpds-4639	348	3	.	.	PUNCT
ijpds-4639	349	1	2003	2003	NUM
ijpds-4639	349	2	;	;	PUNCT
ijpds-4639	349	3	374(1):1	374(1):1	NUM
ijpds-4639	349	4	-	-	SYM
ijpds-4639	349	5	20	20	NUM
ijpds-4639	349	6	.	.	PUNCT
ijpds-4639	350	1	doi:10.1042	doi:10.1042	PROPN
ijpds-4639	350	2	/	/	SYM
ijpds-4639	350	3	bj20030407	bj20030407	PROPN
ijpds-4639	350	4	41	41	NUM
ijpds-4639	350	5	.	.	PUNCT
ijpds-4639	351	1	ihle	ihle	PROPN
ijpds-4639	351	2	jn	jn	PROPN
ijpds-4639	351	3	,	,	PUNCT
ijpds-4639	351	4	kerr	kerr	PROPN
ijpds-4639	351	5	i	i	PRON
ijpds-4639	351	6	m.	m.	NOUN
ijpds-4639	351	7	jaks	jak	NOUN
ijpds-4639	351	8	and	and	CCONJ
ijpds-4639	351	9	stats	stat	VERB
ijpds-4639	351	10	in	in	ADP
ijpds-4639	351	11	signaling	signal	VERB
ijpds-4639	351	12	by	by	ADP
ijpds-4639	351	13	the	the	DET
ijpds-4639	351	14	cytokine	cytokine	ADJ
ijpds-4639	351	15	receptor	receptor	NOUN
ijpds-4639	351	16	superfamily	superfamily	ADV
ijpds-4639	351	17	.	.	PUNCT
ijpds-4639	352	1	trends	trend	NOUN
ijpds-4639	352	2	in	in	ADP
ijpds-4639	352	3	genetics	genetic	NOUN
ijpds-4639	352	4	.	.	PUNCT
ijpds-4639	353	1	1995	1995	NUM
ijpds-4639	353	2	;	;	PUNCT
ijpds-4639	354	1	11(2):69	11(2):69	NUM
ijpds-4639	354	2	-	-	SYM
ijpds-4639	354	3	74	74	NUM
ijpds-4639	354	4	.	.	PUNCT
ijpds-4639	355	1	doi	doi	NOUN
ijpds-4639	355	2	:	:	PUNCT
ijpds-4639	355	3	10.1016	10.1016	NUM
ijpds-4639	355	4	/	/	SYM
ijpds-4639	355	5	s0168	s0168	NOUN
ijpds-4639	355	6	-	-	PUNCT
ijpds-4639	355	7	9525(00)89000	9525(00)89000	NUM
ijpds-4639	355	8	-	-	SYM
ijpds-4639	355	9	9	9	NUM
ijpds-4639	355	10	42	42	NUM
ijpds-4639	355	11	.	.	PUNCT
ijpds-4639	356	1	bahrenberg	bahrenberg	PROPN
ijpds-4639	356	2	g	g	PROPN
ijpds-4639	356	3	,	,	PUNCT
ijpds-4639	356	4	behrmann	behrmann	PROPN
ijpds-4639	356	5	i	i	PROPN
ijpds-4639	356	6	,	,	PUNCT
ijpds-4639	356	7	barthel	barthel	PROPN
ijpds-4639	356	8	a	a	PROPN
ijpds-4639	356	9	,	,	PUNCT
ijpds-4639	356	10	et	et	PROPN
ijpds-4639	356	11	al	al	PROPN
ijpds-4639	356	12	.	.	PUNCT
ijpds-4639	356	13	identification	identification	NOUN
ijpds-4639	356	14	of	of	ADP
ijpds-4639	356	15	the	the	DET
ijpds-4639	356	16	critical	critical	ADJ
ijpds-4639	356	17	sequence	sequence	NOUN
ijpds-4639	356	18	elements	element	NOUN
ijpds-4639	356	19	in	in	ADP
ijpds-4639	356	20	the	the	DET
ijpds-4639	356	21	cytoplasmic	cytoplasmic	ADJ
ijpds-4639	356	22	domain	domain	NOUN
ijpds-4639	356	23	of	of	ADP
ijpds-4639	356	24	leptin	leptin	NOUN
ijpds-4639	356	25	receptor	receptor	NOUN
ijpds-4639	356	26	isoforms	isoform	NOUN
ijpds-4639	356	27	required	require	VERB
ijpds-4639	356	28	for	for	ADP
ijpds-4639	356	29	janus	janus	PROPN
ijpds-4639	356	30	kinase	kinase	PROPN
ijpds-4639	356	31	/	/	SYM
ijpds-4639	356	32	signal	signal	NOUN
ijpds-4639	356	33	transducer	transducer	NOUN
ijpds-4639	356	34	and	and	CCONJ
ijpds-4639	356	35	activator	activator	NOUN
ijpds-4639	356	36	of	of	ADP
ijpds-4639	356	37	transcription	transcription	NOUN
ijpds-4639	356	38	activation	activation	NOUN
ijpds-4639	356	39	by	by	ADP
ijpds-4639	356	40	receptor	receptor	NOUN
ijpds-4639	356	41	heterodimers	heterodimer	NOUN
ijpds-4639	356	42	.	.	PUNCT
ijpds-4639	357	1	https://doi.org/10.1210/en.2013-1823	https://doi.org/10.1210/en.2013-1823	PROPN
ijpds-4639	357	2	https://doi.org/10.1016/s0140-6736(96)03173-x	https://doi.org/10.1016/s0140-6736(96)03173-x	PROPN
ijpds-4639	357	3	https://doi.org/10.1210/endo.139.8.6154	https://doi.org/10.1210/endo.139.8.6154	PROPN
ijpds-4639	357	4	https://doi.org/10.1016/s1534-5807(02)00148-x	https://doi.org/10.1016/s1534-5807(02)00148-x	PROPN
ijpds-4639	357	5	https://doi.org/10.1016/j.yhbeh.2021.105006	https://doi.org/10.1016/j.yhbeh.2021.105006	VERB
ijpds-4639	357	6	https://doi.org/10.1016/j.bmcl.2010.08.130	https://doi.org/10.1016/j.bmcl.2010.08.130	X
ijpds-4639	357	7	https://doi.org/10.1097/00042192-200007010-00007	https://doi.org/10.1097/00042192-200007010-00007	VERB
ijpds-4639	357	8	https://doi.org/10.1080/09513590600842281	https://doi.org/10.1080/09513590600842281	NOUN
ijpds-4639	357	9	https://doi.org/10.1016/s0378-5122(00)00153-5	https://doi.org/10.1016/s0378-5122(00)00153-5	VERB
ijpds-4639	357	10	https://doi.org/10.1016/j.fertnstert.2006.11.142	https://doi.org/10.1016/j.fertnstert.2006.11.142	NOUN
ijpds-4639	357	11	https://doi.org/10.1016/j.metabol.2010.02.007	https://doi.org/10.1016/j.metabol.2010.02.007	VERB
ijpds-4639	357	12	https://doi.org/10.1016/j.cmet.2012.07.002	https://doi.org/10.1016/j.cmet.2012.07.002	NOUN
ijpds-4639	357	13	https://doi.org/10.1073/pnas.93.16.8374	https://doi.org/10.1073/pnas.93.16.8374	NOUN
ijpds-4639	357	14	https://doi.org/10.1073/pnas.93.13.6231	https://doi.org/10.1073/pnas.93.13.6231	PROPN
ijpds-4639	357	15	https://doi.org/10.1042/bj20030407	https://doi.org/10.1042/bj20030407	VERB
ijpds-4639	358	1	https://doi.org/10.1016/s0168-9525(00)89000-9	https://doi.org/10.1016/s0168-9525(00)89000-9	PROPN
ijpds-4639	358	2	singha	singha	PROPN
ijpds-4639	358	3	et	et	PROPN
ijpds-4639	358	4	al	al	PROPN
ijpds-4639	358	5	.	.	PROPN
ijpds-4639	358	6	leptin	leptin	PROPN
ijpds-4639	358	7	:	:	PUNCT
ijpds-4639	358	8	its	its	PRON
ijpds-4639	358	9	crucial	crucial	ADJ
ijpds-4639	358	10	role	role	NOUN
ijpds-4639	358	11	in	in	ADP
ijpds-4639	358	12	the	the	DET
ijpds-4639	358	13	fight	fight	NOUN
ijpds-4639	358	14	against	against	ADP
ijpds-4639	358	15	obesity	obesity	NOUN
ijpds-4639	358	16	online	online	ADJ
ijpds-4639	358	17	first	first	PROPN
ijpds-4639	358	18	indian	indian	PROPN
ijpds-4639	358	19	j	j	PROPN
ijpds-4639	358	20	pharm	pharm	PROPN
ijpds-4639	358	21	drug	drug	PROPN
ijpds-4639	358	22	studies	study	NOUN
ijpds-4639	358	23	|	|	ADV
ijpds-4639	358	24	7	7	NUM
ijpds-4639	358	25	molecular	molecular	ADJ
ijpds-4639	358	26	endocrinology	endocrinology	NOUN
ijpds-4639	358	27	.	.	PUNCT
ijpds-4639	359	1	2002	2002	NUM
ijpds-4639	359	2	;	;	PUNCT
ijpds-4639	359	3	16(4):859	16(4):859	NUM
ijpds-4639	359	4	-	-	SYM
ijpds-4639	359	5	72	72	NUM
ijpds-4639	359	6	.	.	PUNCT
ijpds-4639	360	1	doi:10.1210	doi:10.1210	PROPN
ijpds-4639	360	2	/	/	SYM
ijpds-4639	360	3	mend.16.4.0800	mend.16.4.0800	PROPN
ijpds-4639	360	4	43	43	NUM
ijpds-4639	360	5	.	.	PUNCT
ijpds-4639	361	1	kloek	kloek	PROPN
ijpds-4639	361	2	c	c	PROPN
ijpds-4639	361	3	,	,	PUNCT
ijpds-4639	361	4	haq	haq	PROPN
ijpds-4639	361	5	ak	ak	PROPN
ijpds-4639	361	6	,	,	PUNCT
ijpds-4639	361	7	dunn	dunn	PROPN
ijpds-4639	361	8	sl	sl	PROPN
ijpds-4639	361	9	,	,	PUNCT
ijpds-4639	361	10	et	et	PROPN
ijpds-4639	361	11	al	al	PROPN
ijpds-4639	361	12	.	.	PUNCT
ijpds-4639	361	13	regulation	regulation	NOUN
ijpds-4639	361	14	of	of	ADP
ijpds-4639	361	15	jak	jak	PROPN
ijpds-4639	361	16	kinases	kinase	NOUN
ijpds-4639	361	17	by	by	ADP
ijpds-4639	361	18	intracellular	intracellular	ADJ
ijpds-4639	361	19	leptin	leptin	NOUN
ijpds-4639	361	20	receptor	receptor	NOUN
ijpds-4639	361	21	sequences	sequence	NOUN
ijpds-4639	361	22	.	.	PUNCT
ijpds-4639	362	1	journal	journal	PROPN
ijpds-4639	362	2	of	of	ADP
ijpds-4639	362	3	biological	biological	ADJ
ijpds-4639	362	4	chemistry	chemistry	NOUN
ijpds-4639	362	5	.	.	PUNCT
ijpds-4639	363	1	2002	2002	NUM
ijpds-4639	363	2	;	;	PUNCT
ijpds-4639	364	1	277(44):41547	277(44):41547	PROPN
ijpds-4639	364	2	-	-	SYM
ijpds-4639	364	3	55	55	NUM
ijpds-4639	364	4	.	.	PUNCT
ijpds-4639	365	1	doi	doi	NOUN
ijpds-4639	365	2	:	:	PUNCT
ijpds-4639	365	3	10.1074	10.1074	NUM
ijpds-4639	365	4	/	/	SYM
ijpds-4639	365	5	jbc.m205148200	jbc.m205148200	NOUN
ijpds-4639	365	6	44	44	NUM
ijpds-4639	365	7	.	.	PUNCT
ijpds-4639	366	1	murakami	murakami	PROPN
ijpds-4639	366	2	t	t	PROPN
ijpds-4639	366	3	,	,	PUNCT
ijpds-4639	366	4	yamashita	yamashita	PROPN
ijpds-4639	366	5	t	t	PROPN
ijpds-4639	366	6	,	,	PUNCT
ijpds-4639	366	7	iida	iida	PROPN
ijpds-4639	366	8	m	m	PROPN
ijpds-4639	366	9	,	,	PUNCT
ijpds-4639	366	10	et	et	PROPN
ijpds-4639	366	11	al	al	PROPN
ijpds-4639	366	12	.	.	PUNCT
ijpds-4639	367	1	a	a	DET
ijpds-4639	367	2	short	short	ADJ
ijpds-4639	367	3	form	form	NOUN
ijpds-4639	367	4	of	of	ADP
ijpds-4639	367	5	leptin	leptin	NOUN
ijpds-4639	367	6	receptor	receptor	NOUN
ijpds-4639	367	7	performs	perform	VERB
ijpds-4639	367	8	signal	signal	VERB
ijpds-4639	367	9	transduction	transduction	NOUN
ijpds-4639	367	10	.	.	PUNCT
ijpds-4639	368	1	biochemical	biochemical	ADJ
ijpds-4639	368	2	and	and	CCONJ
ijpds-4639	368	3	biophysical	biophysical	ADJ
ijpds-4639	368	4	research	research	NOUN
ijpds-4639	368	5	communications	communication	NOUN
ijpds-4639	368	6	.	.	PUNCT
ijpds-4639	369	1	1997	1997	NUM
ijpds-4639	369	2	;	;	PUNCT
ijpds-4639	369	3	231(1):26	231(1):26	NUM
ijpds-4639	369	4	-	-	SYM
ijpds-4639	369	5	9	9	NUM
ijpds-4639	369	6	.	.	PUNCT
ijpds-4639	369	7	doi	doi	NOUN
ijpds-4639	369	8	:	:	PUNCT
ijpds-4639	369	9	10.1006	10.1006	NUM
ijpds-4639	369	10	/	/	SYM
ijpds-4639	369	11	bbrc.1996.6030	bbrc.1996.6030	PROPN
ijpds-4639	369	12	45	45	NUM
ijpds-4639	369	13	.	.	PUNCT
ijpds-4639	370	1	bjørbæk	bjørbæk	PROPN
ijpds-4639	370	2	c	c	X
ijpds-4639	370	3	,	,	PUNCT
ijpds-4639	370	4	elmquist	elmquist	PROPN
ijpds-4639	370	5	jk	jk	PROPN
ijpds-4639	370	6	,	,	PUNCT
ijpds-4639	370	7	michl	michl	VERB
ijpds-4639	370	8	p	p	X
ijpds-4639	370	9	,	,	PUNCT
ijpds-4639	370	10	et	et	PROPN
ijpds-4639	370	11	al	al	PROPN
ijpds-4639	370	12	.	.	PUNCT
ijpds-4639	371	1	expression	expression	NOUN
ijpds-4639	371	2	of	of	ADP
ijpds-4639	371	3	leptin	leptin	NOUN
ijpds-4639	371	4	receptor	receptor	NOUN
ijpds-4639	371	5	isoforms	isoform	NOUN
ijpds-4639	371	6	in	in	ADP
ijpds-4639	371	7	rat	rat	NOUN
ijpds-4639	371	8	brain	brain	NOUN
ijpds-4639	371	9	microvessels	microvessel	NOUN
ijpds-4639	371	10	.	.	PUNCT
ijpds-4639	372	1	endocrinology	endocrinology	NOUN
ijpds-4639	372	2	.	.	PUNCT
ijpds-4639	373	1	1998	1998	NUM
ijpds-4639	373	2	;	;	PUNCT
ijpds-4639	374	1	139(8):3485	139(8):3485	PROPN
ijpds-4639	374	2	-	-	SYM
ijpds-4639	374	3	91	91	NUM
ijpds-4639	374	4	.	.	PUNCT
ijpds-4639	375	1	doi	doi	NOUN
ijpds-4639	375	2	:	:	PUNCT
ijpds-4639	375	3	10.1210	10.1210	NUM
ijpds-4639	375	4	/	/	SYM
ijpds-4639	375	5	endo.139.8.6154	endo.139.8.6154	NOUN
ijpds-4639	375	6	46	46	NUM
ijpds-4639	375	7	.	.	PUNCT
ijpds-4639	376	1	mori	mori	PROPN
ijpds-4639	376	2	h	h	PROPN
ijpds-4639	376	3	,	,	PUNCT
ijpds-4639	376	4	hanada	hanada	PROPN
ijpds-4639	376	5	r	r	NOUN
ijpds-4639	376	6	,	,	PUNCT
ijpds-4639	376	7	hanada	hanada	PROPN
ijpds-4639	376	8	t	t	PROPN
ijpds-4639	376	9	,	,	PUNCT
ijpds-4639	376	10	et	et	PROPN
ijpds-4639	376	11	al	al	PROPN
ijpds-4639	376	12	.	.	PUNCT
ijpds-4639	377	1	socs3	socs3	ADJ
ijpds-4639	377	2	deficiency	deficiency	NOUN
ijpds-4639	377	3	in	in	ADP
ijpds-4639	377	4	the	the	DET
ijpds-4639	377	5	brain	brain	NOUN
ijpds-4639	377	6	elevates	elevate	VERB
ijpds-4639	377	7	leptin	leptin	NOUN
ijpds-4639	377	8	sensitivity	sensitivity	NOUN
ijpds-4639	377	9	and	and	CCONJ
ijpds-4639	377	10	confers	confer	NOUN
ijpds-4639	377	11	resistance	resistance	NOUN
ijpds-4639	377	12	to	to	ADP
ijpds-4639	377	13	diet	diet	NOUN
ijpds-4639	377	14	-	-	PUNCT
ijpds-4639	377	15	induced	induce	VERB
ijpds-4639	377	16	obesity	obesity	NOUN
ijpds-4639	377	17	.	.	PUNCT
ijpds-4639	378	1	nature	nature	NOUN
ijpds-4639	378	2	medicine	medicine	NOUN
ijpds-4639	378	3	.	.	PUNCT
ijpds-4639	379	1	2004	2004	NUM
ijpds-4639	379	2	;	;	PUNCT
ijpds-4639	379	3	10(7):739	10(7):739	NUM
ijpds-4639	379	4	-	-	SYM
ijpds-4639	379	5	43	43	NUM
ijpds-4639	379	6	.	.	PUNCT
ijpds-4639	380	1	doi	doi	NOUN
ijpds-4639	380	2	:	:	PUNCT
ijpds-4639	380	3	10.1038	10.1038	NUM
ijpds-4639	380	4	/	/	SYM
ijpds-4639	380	5	nm1071	nm1071	PROPN
ijpds-4639	380	6	47	47	NUM
ijpds-4639	380	7	.	.	PUNCT
ijpds-4639	381	1	rahmouni	rahmouni	PROPN
ijpds-4639	381	2	k.	k.	PROPN
ijpds-4639	381	3	mitogen	mitogen	PROPN
ijpds-4639	381	4	activated	activate	VERB
ijpds-4639	381	5	protein	protein	NOUN
ijpds-4639	381	6	kinase	kinase	NOUN
ijpds-4639	381	7	:	:	PUNCT
ijpds-4639	381	8	a	a	DET
ijpds-4639	381	9	newly	newly	ADV
ijpds-4639	381	10	discovered	discover	VERB
ijpds-4639	381	11	mediator	mediator	NOUN
ijpds-4639	381	12	of	of	ADP
ijpds-4639	381	13	selective	selective	ADJ
ijpds-4639	381	14	leptin	leptin	NOUN
ijpds-4639	381	15	action	action	NOUN
ijpds-4639	381	16	.	.	PUNCT
ijpds-4639	382	1	hypertension	hypertension	NOUN
ijpds-4639	382	2	.	.	PUNCT
ijpds-4639	383	1	2005	2005	NUM
ijpds-4639	383	2	;	;	PUNCT
ijpds-4639	383	3	46:867	46:867	NUM
ijpds-4639	383	4	.	.	PUNCT
ijpds-4639	384	1	doi	doi	NOUN
ijpds-4639	384	2	:	:	PUNCT
ijpds-4639	384	3	10.1161	10.1161	NUM
ijpds-4639	384	4	/	/	SYM
ijpds-4639	384	5	hyp.46.5.814	hyp.46.5.814	PROPN
ijpds-4639	384	6	48	48	NUM
ijpds-4639	384	7	.	.	PUNCT
ijpds-4639	385	1	bates	bates	PROPN
ijpds-4639	385	2	sh	sh	PROPN
ijpds-4639	385	3	,	,	PUNCT
ijpds-4639	385	4	stearns	stearns	PROPN
ijpds-4639	385	5	wh	wh	PROPN
ijpds-4639	385	6	,	,	PUNCT
ijpds-4639	385	7	dundon	dundon	PROPN
ijpds-4639	385	8	ta	ta	PROPN
ijpds-4639	385	9	,	,	PUNCT
ijpds-4639	385	10	et	et	PROPN
ijpds-4639	385	11	al	al	PROPN
ijpds-4639	385	12	.	.	PUNCT
ijpds-4639	386	1	stat3	stat3	NOUN
ijpds-4639	386	2	signalling	signal	VERB
ijpds-4639	386	3	is	be	AUX
ijpds-4639	386	4	required	require	VERB
ijpds-4639	386	5	for	for	ADP
ijpds-4639	386	6	leptin	leptin	NOUN
ijpds-4639	386	7	regulation	regulation	NOUN
ijpds-4639	386	8	of	of	ADP
ijpds-4639	386	9	energy	energy	NOUN
ijpds-4639	386	10	balance	balance	NOUN
ijpds-4639	386	11	but	but	CCONJ
ijpds-4639	386	12	not	not	PART
ijpds-4639	386	13	reproduction	reproduction	NOUN
ijpds-4639	386	14	.	.	PUNCT
ijpds-4639	387	1	nature	nature	NOUN
ijpds-4639	387	2	.	.	PUNCT
ijpds-4639	388	1	2003	2003	NUM
ijpds-4639	388	2	;	;	PUNCT
ijpds-4639	388	3	421(6925):856	421(6925):856	NUM
ijpds-4639	388	4	-	-	SYM
ijpds-4639	388	5	9	9	NUM
ijpds-4639	388	6	.	.	PUNCT
ijpds-4639	388	7	doi	doi	NOUN
ijpds-4639	388	8	:	:	PUNCT
ijpds-4639	388	9	10.1038	10.1038	NUM
ijpds-4639	388	10	/	/	SYM
ijpds-4639	388	11	nature01388	nature01388	PROPN
ijpds-4639	388	12	49	49	NUM
ijpds-4639	388	13	.	.	PUNCT
ijpds-4639	389	1	faggioni	faggioni	PROPN
ijpds-4639	389	2	r	r	NOUN
ijpds-4639	389	3	,	,	PUNCT
ijpds-4639	389	4	fantuzzi	fantuzzi	NOUN
ijpds-4639	389	5	g	g	NOUN
ijpds-4639	389	6	,	,	PUNCT
ijpds-4639	389	7	fuller	full	ADJ
ijpds-4639	389	8	j	j	PROPN
ijpds-4639	389	9	,	,	PUNCT
ijpds-4639	389	10	et	et	PROPN
ijpds-4639	389	11	al	al	PROPN
ijpds-4639	389	12	.	.	PUNCT
ijpds-4639	390	1	il-1β	il-1β	PROPN
ijpds-4639	390	2	mediates	mediate	NOUN
ijpds-4639	390	3	leptin	leptin	VERB
ijpds-4639	390	4	induction	induction	NOUN
ijpds-4639	390	5	during	during	ADP
ijpds-4639	390	6	inflammation	inflammation	NOUN
ijpds-4639	390	7	.	.	PUNCT
ijpds-4639	391	1	american	american	ADJ
ijpds-4639	391	2	journal	journal	PROPN
ijpds-4639	391	3	of	of	ADP
ijpds-4639	391	4	physiology	physiology	NOUN
ijpds-4639	391	5	regulatory	regulatory	ADJ
ijpds-4639	391	6	,	,	PUNCT
ijpds-4639	391	7	integrative	integrative	ADJ
ijpds-4639	391	8	and	and	CCONJ
ijpds-4639	391	9	comparative	comparative	ADJ
ijpds-4639	391	10	physiology	physiology	NOUN
ijpds-4639	391	11	.	.	PUNCT
ijpds-4639	392	1	1998	1998	NUM
ijpds-4639	392	2	;	;	PUNCT
ijpds-4639	392	3	274(1):r204	274(1):r204	NUM
ijpds-4639	392	4	-	-	SYM
ijpds-4639	392	5	8	8	NUM
ijpds-4639	392	6	.	.	PUNCT
ijpds-4639	392	7	doi:10.1152	doi:10.1152	NOUN
ijpds-4639	392	8	/	/	SYM
ijpds-4639	392	9	ajpregu.1998.274.1.r204	ajpregu.1998.274.1.r204	NOUN
ijpds-4639	392	10	50	50	NUM
ijpds-4639	392	11	.	.	PUNCT
ijpds-4639	393	1	gabay	gabay	PROPN
ijpds-4639	393	2	c	c	PROPN
ijpds-4639	393	3	,	,	PUNCT
ijpds-4639	393	4	dreyer	dreyer	PROPN
ijpds-4639	393	5	mg	mg	PROPN
ijpds-4639	393	6	,	,	PUNCT
ijpds-4639	393	7	pellegrinelli	pellegrinelli	PROPN
ijpds-4639	393	8	n	n	CCONJ
ijpds-4639	393	9	,	,	PUNCT
ijpds-4639	393	10	et	et	PROPN
ijpds-4639	393	11	al	al	PROPN
ijpds-4639	393	12	.	.	PROPN
ijpds-4639	393	13	leptin	leptin	PROPN
ijpds-4639	393	14	directly	directly	ADV
ijpds-4639	393	15	induces	induce	VERB
ijpds-4639	393	16	the	the	DET
ijpds-4639	393	17	secretion	secretion	NOUN
ijpds-4639	393	18	of	of	ADP
ijpds-4639	393	19	interleukin	interleukin	NOUN
ijpds-4639	393	20	1	1	NUM
ijpds-4639	393	21	receptor	receptor	NOUN
ijpds-4639	393	22	antagonist	antagonist	NOUN
ijpds-4639	393	23	in	in	ADP
ijpds-4639	393	24	human	human	ADJ
ijpds-4639	393	25	monocytes	monocyte	NOUN
ijpds-4639	393	26	.	.	PUNCT
ijpds-4639	394	1	the	the	DET
ijpds-4639	394	2	journal	journal	NOUN
ijpds-4639	394	3	of	of	ADP
ijpds-4639	394	4	clinical	clinical	ADJ
ijpds-4639	394	5	endocrinology	endocrinology	NOUN
ijpds-4639	394	6	&	&	CCONJ
ijpds-4639	394	7	metabolism	metabolism	NOUN
ijpds-4639	394	8	.	.	PUNCT
ijpds-4639	395	1	2001	2001	NUM
ijpds-4639	395	2	;	;	PUNCT
ijpds-4639	395	3	86(2):783	86(2):783	NUM
ijpds-4639	395	4	-	-	SYM
ijpds-4639	395	5	91	91	NUM
ijpds-4639	395	6	.	.	PUNCT
ijpds-4639	396	1	doi:10.1210	doi:10.1210	PROPN
ijpds-4639	396	2	/	/	SYM
ijpds-4639	396	3	jcem.86.2.7245	jcem.86.2.7245	PROPN
ijpds-4639	396	4	51	51	NUM
ijpds-4639	396	5	.	.	PUNCT
ijpds-4639	397	1	weisberg	weisberg	PROPN
ijpds-4639	397	2	sp	sp	PROPN
ijpds-4639	397	3	,	,	PUNCT
ijpds-4639	397	4	mccann	mccann	PROPN
ijpds-4639	397	5	d	d	PROPN
ijpds-4639	397	6	,	,	PUNCT
ijpds-4639	397	7	desai	desai	PROPN
ijpds-4639	397	8	m	m	PROPN
ijpds-4639	397	9	,	,	PUNCT
ijpds-4639	397	10	et	et	PROPN
ijpds-4639	397	11	al	al	PROPN
ijpds-4639	397	12	.	.	PROPN
ijpds-4639	397	13	obesity	obesity	NOUN
ijpds-4639	397	14	is	be	AUX
ijpds-4639	397	15	associated	associate	VERB
ijpds-4639	397	16	with	with	ADP
ijpds-4639	397	17	macrophage	macrophage	ADJ
ijpds-4639	397	18	accumulation	accumulation	NOUN
ijpds-4639	397	19	in	in	ADP
ijpds-4639	397	20	adipose	adipose	ADJ
ijpds-4639	397	21	tissue	tissue	NOUN
ijpds-4639	397	22	.	.	PUNCT
ijpds-4639	398	1	the	the	DET
ijpds-4639	398	2	journal	journal	NOUN
ijpds-4639	398	3	of	of	ADP
ijpds-4639	398	4	clinical	clinical	ADJ
ijpds-4639	398	5	investigation	investigation	NOUN
ijpds-4639	398	6	.	.	PUNCT
ijpds-4639	399	1	2003	2003	NUM
ijpds-4639	399	2	;	;	PUNCT
ijpds-4639	399	3	112(12):1796	112(12):1796	PROPN
ijpds-4639	399	4	-	-	PUNCT
ijpds-4639	399	5	808	808	NUM
ijpds-4639	399	6	.	.	PUNCT
ijpds-4639	399	7	doi	doi	NOUN
ijpds-4639	399	8	:	:	PUNCT
ijpds-4639	399	9	10.1172	10.1172	NUM
ijpds-4639	399	10	/	/	SYM
ijpds-4639	399	11	jci200319246	jci200319246	PROPN
ijpds-4639	399	12	52	52	NUM
ijpds-4639	399	13	.	.	PUNCT
ijpds-4639	400	1	obradovic	obradovic	PROPN
ijpds-4639	400	2	m	m	NOUN
ijpds-4639	400	3	,	,	PUNCT
ijpds-4639	400	4	sudar	sudar	ADV
ijpds-4639	400	5	-	-	PUNCT
ijpds-4639	400	6	milovanovic	milovanovic	ADJ
ijpds-4639	400	7	e	e	NOUN
ijpds-4639	400	8	,	,	PUNCT
ijpds-4639	400	9	soskic	soskic	PROPN
ijpds-4639	400	10	s	s	PROPN
ijpds-4639	400	11	,	,	PUNCT
ijpds-4639	400	12	et	et	PROPN
ijpds-4639	400	13	al	al	PROPN
ijpds-4639	400	14	.	.	PROPN
ijpds-4639	400	15	leptin	leptin	PROPN
ijpds-4639	400	16	and	and	CCONJ
ijpds-4639	400	17	obesity	obesity	NOUN
ijpds-4639	400	18	:	:	PUNCT
ijpds-4639	400	19	role	role	NOUN
ijpds-4639	400	20	and	and	CCONJ
ijpds-4639	400	21	clinical	clinical	ADJ
ijpds-4639	400	22	implication	implication	NOUN
ijpds-4639	400	23	.	.	PUNCT
ijpds-4639	401	1	frontiers	frontier	NOUN
ijpds-4639	401	2	in	in	ADP
ijpds-4639	401	3	endocrinology	endocrinology	NOUN
ijpds-4639	401	4	.	.	PUNCT
ijpds-4639	401	5	2021	2021	NUM
ijpds-4639	401	6	;	;	PUNCT
ijpds-4639	401	7	12:585887	12:585887	NUM
ijpds-4639	401	8	.	.	PUNCT
ijpds-4639	402	1	doi:10.3389	doi:10.3389	PROPN
ijpds-4639	402	2	/	/	SYM
ijpds-4639	402	3	fendo.2021.585887	fendo.2021.585887	PROPN
ijpds-4639	402	4	how	how	SCONJ
ijpds-4639	402	5	to	to	PART
ijpds-4639	402	6	cite	cite	VERB
ijpds-4639	402	7	this	this	DET
ijpds-4639	402	8	article	article	NOUN
ijpds-4639	402	9	:	:	PUNCT
ijpds-4639	402	10	singha	singha	PROPN
ijpds-4639	402	11	s	s	PROPN
ijpds-4639	402	12	,	,	PUNCT
ijpds-4639	402	13	nayak	nayak	PROPN
ijpds-4639	402	14	s	s	PROPN
ijpds-4639	402	15	,	,	PUNCT
ijpds-4639	402	16	bishayee	bishayee	ADJ
ijpds-4639	402	17	r	r	NOUN
ijpds-4639	402	18	,	,	PUNCT
ijpds-4639	402	19	sarkar	sarkar	NOUN
ijpds-4639	402	20	p	p	X
ijpds-4639	402	21	,	,	PUNCT
ijpds-4639	402	22	ghosh	ghosh	PROPN
ijpds-4639	402	23	p	p	PROPN
ijpds-4639	402	24	,	,	PUNCT
ijpds-4639	402	25	dutta	dutta	PROPN
ijpds-4639	402	26	u	u	PROPN
ijpds-4639	402	27	,	,	PUNCT
ijpds-4639	402	28	mishra	mishra	PROPN
ijpds-4639	402	29	p.	p.	PROPN
ijpds-4639	402	30	decoding	decode	VERB
ijpds-4639	402	31	leptin	leptin	NOUN
ijpds-4639	402	32	:	:	PUNCT
ijpds-4639	402	33	unraveling	unravel	VERB
ijpds-4639	402	34	the	the	DET
ijpds-4639	402	35	role	role	NOUN
ijpds-4639	402	36	of	of	ADP
ijpds-4639	402	37	leptin	leptin	NOUN
ijpds-4639	402	38	signaling	signal	VERB
ijpds-4639	402	39	in	in	ADP
ijpds-4639	402	40	the	the	DET
ijpds-4639	402	41	battle	battle	NOUN
ijpds-4639	402	42	against	against	ADP
ijpds-4639	402	43	obesity	obesity	NOUN
ijpds-4639	402	44	.	.	PUNCT
ijpds-4639	403	1	indian	indian	PROPN
ijpds-4639	403	2	j	j	PROPN
ijpds-4639	403	3	pharm	pharm	PROPN
ijpds-4639	403	4	drug	drug	PROPN
ijpds-4639	403	5	studies	study	NOUN
ijpds-4639	403	6	.	.	PUNCT
ijpds-4639	403	7	2024	2024	NUM
ijpds-4639	403	8	;	;	PUNCT
ijpds-4639	403	9	online	online	ADJ
ijpds-4639	403	10	first	first	ADJ
ijpds-4639	403	11	.	.	PUNCT
ijpds-4639	404	1	funding	funding	NOUN
ijpds-4639	404	2	:	:	PUNCT
ijpds-4639	404	3	none	none	NOUN
ijpds-4639	404	4	;	;	PUNCT
ijpds-4639	404	5	conflicts	conflict	NOUN
ijpds-4639	404	6	of	of	ADP
ijpds-4639	404	7	interest	interest	NOUN
ijpds-4639	404	8	:	:	PUNCT
ijpds-4639	404	9	none	none	NOUN
ijpds-4639	404	10	stated	state	VERB
ijpds-4639	404	11	https://doi.org/10.1210/mend.16.4.0800	https://doi.org/10.1210/mend.16.4.0800	PROPN
ijpds-4639	404	12	https://doi.org/10.1152/ajpregu.1998.274.1.r204	https://doi.org/10.1152/ajpregu.1998.274.1.r204	PROPN
ijpds-4639	404	13	https://doi.org/10.1210/jcem.86.2.7245	https://doi.org/10.1210/jcem.86.2.7245	PROPN
ijpds-4639	404	14	https://doi.org/10.3389/fendo.2021.585887	https://doi.org/10.3389/fendo.2021.585887	PROPN