id	sid	tid	token	lemma	pos
ijpds-4738	1	1	patil	patil	PROPN
ijpds-4738	1	2	et	et	PROPN
ijpds-4738	1	3	al	al	PROPN
ijpds-4738	1	4	.	.	PROPN
ijpds-4738	2	1	analytical	analytical	ADJ
ijpds-4738	2	2	method	method	PROPN
ijpds-4738	2	3	development	development	NOUN
ijpds-4738	2	4	and	and	CCONJ
ijpds-4738	2	5	validation	validation	NOUN
ijpds-4738	2	6	online	online	ADJ
ijpds-4738	2	7	first	first	PROPN
ijpds-4738	2	8	indian	indian	PROPN
ijpds-4738	2	9	j	j	PROPN
ijpds-4738	2	10	pharm	pharm	PROPN
ijpds-4738	2	11	drug	drug	PROPN
ijpds-4738	2	12	studies	study	NOUN
ijpds-4738	2	13	|	|	ADV
ijpds-4738	2	14	1	1	NUM
ijpds-4738	2	15	review	review	NOUN
ijpds-4738	2	16	article	article	NOUN
ijpds-4738	2	17	analytical	analytical	ADJ
ijpds-4738	2	18	method	method	NOUN
ijpds-4738	2	19	development	development	NOUN
ijpds-4738	2	20	and	and	CCONJ
ijpds-4738	2	21	validation	validation	NOUN
ijpds-4738	2	22	rutik	rutik	PROPN
ijpds-4738	2	23	nitin	nitin	PROPN
ijpds-4738	2	24	patil1	patil1	PROPN
ijpds-4738	2	25	,	,	PUNCT
ijpds-4738	2	26	bhupendra	bhupendra	PROPN
ijpds-4738	2	27	l	l	PROPN
ijpds-4738	2	28	deore2	deore2	PROPN
ijpds-4738	2	29	,	,	PUNCT
ijpds-4738	2	30	darshan	darshan	PROPN
ijpds-4738	2	31	ganesh	ganesh	PROPN
ijpds-4738	2	32	gurav1	gurav1	PROPN
ijpds-4738	2	33	from	from	ADP
ijpds-4738	2	34	,	,	PUNCT
ijpds-4738	2	35	1m.pharm	1m.pharm	NUM
ijpds-4738	2	36	,	,	PUNCT
ijpds-4738	2	37	2phd	2phd	PROPN
ijpds-4738	2	38	&	&	CCONJ
ijpds-4738	2	39	m	m	PROPN
ijpds-4738	2	40	pharm	pharm	PROPN
ijpds-4738	2	41	,	,	PUNCT
ijpds-4738	2	42	department	department	NOUN
ijpds-4738	2	43	of	of	ADP
ijpds-4738	2	44	quality	quality	NOUN
ijpds-4738	2	45	assurance	assurance	NOUN
ijpds-4738	2	46	,	,	PUNCT
ijpds-4738	2	47	a.r.a	a.r.a	ADJ
ijpds-4738	2	48	college	college	NOUN
ijpds-4738	2	49	of	of	ADP
ijpds-4738	2	50	pharmacy	pharmacy	NOUN
ijpds-4738	2	51	,	,	PUNCT
ijpds-4738	2	52	dhule	dhule	NOUN
ijpds-4738	2	53	,	,	PUNCT
ijpds-4738	2	54	india	india	PROPN
ijpds-4738	2	55	.	.	PUNCT
ijpds-4738	3	1	abstract	abstract	ADJ
ijpds-4738	3	2	the	the	DET
ijpds-4738	3	3	main	main	ADJ
ijpds-4738	3	4	objective	objective	NOUN
ijpds-4738	3	5	of	of	ADP
ijpds-4738	3	6	the	the	DET
ijpds-4738	3	7	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	3	8	business	business	NOUN
ijpds-4738	3	9	is	be	AUX
ijpds-4738	3	10	to	to	PART
ijpds-4738	3	11	consistently	consistently	ADV
ijpds-4738	3	12	and	and	CCONJ
ijpds-4738	3	13	economically	economically	ADV
ijpds-4738	3	14	create	create	VERB
ijpds-4738	3	15	goods	good	NOUN
ijpds-4738	3	16	with	with	ADP
ijpds-4738	3	17	the	the	DET
ijpds-4738	3	18	requisite	requisite	ADJ
ijpds-4738	3	19	features	feature	NOUN
ijpds-4738	3	20	and	and	CCONJ
ijpds-4738	3	21	quality	quality	NOUN
ijpds-4738	3	22	.	.	PUNCT
ijpds-4738	4	1	the	the	DET
ijpds-4738	4	2	process	process	NOUN
ijpds-4738	4	3	of	of	ADP
ijpds-4738	4	4	finding	finding	NOUN
ijpds-4738	4	5	,	,	PUNCT
ijpds-4738	4	6	creating	create	VERB
ijpds-4738	4	7	,	,	PUNCT
ijpds-4738	4	8	and	and	CCONJ
ijpds-4738	4	9	assessing	assess	VERB
ijpds-4738	4	10	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	4	11	formulations	formulation	NOUN
ijpds-4738	4	12	requires	require	VERB
ijpds-4738	4	13	the	the	DET
ijpds-4738	4	14	creation	creation	NOUN
ijpds-4738	4	15	of	of	ADP
ijpds-4738	4	16	a	a	DET
ijpds-4738	4	17	methodology	methodology	NOUN
ijpds-4738	4	18	.	.	PUNCT
ijpds-4738	5	1	the	the	DET
ijpds-4738	5	2	primary	primary	ADJ
ijpds-4738	5	3	goal	goal	NOUN
ijpds-4738	5	4	of	of	ADP
ijpds-4738	5	5	this	this	DET
ijpds-4738	5	6	review	review	NOUN
ijpds-4738	5	7	article	article	NOUN
ijpds-4738	5	8	is	be	AUX
ijpds-4738	5	9	to	to	PART
ijpds-4738	5	10	examine	examine	VERB
ijpds-4738	5	11	how	how	SCONJ
ijpds-4738	5	12	the	the	DET
ijpds-4738	5	13	medication	medication	NOUN
ijpds-4738	5	14	development	development	NOUN
ijpds-4738	5	15	and	and	CCONJ
ijpds-4738	5	16	validation	validation	NOUN
ijpds-4738	5	17	process	process	NOUN
ijpds-4738	5	18	was	be	AUX
ijpds-4738	5	19	carried	carry	VERB
ijpds-4738	5	20	out	out	ADP
ijpds-4738	5	21	,	,	PUNCT
ijpds-4738	5	22	from	from	ADP
ijpds-4738	5	23	the	the	DET
ijpds-4738	5	24	beginning	beginning	NOUN
ijpds-4738	5	25	of	of	ADP
ijpds-4738	5	26	the	the	DET
ijpds-4738	5	27	formulation	formulation	NOUN
ijpds-4738	5	28	to	to	ADP
ijpds-4738	5	29	the	the	DET
ijpds-4738	5	30	end	end	NOUN
ijpds-4738	5	31	of	of	ADP
ijpds-4738	5	32	the	the	DET
ijpds-4738	5	33	commercial	commercial	ADJ
ijpds-4738	5	34	batch	batch	NOUN
ijpds-4738	5	35	.	.	PUNCT
ijpds-4738	6	1	reliability	reliability	NOUN
ijpds-4738	6	2	of	of	ADP
ijpds-4738	6	3	the	the	DET
ijpds-4738	6	4	results	result	NOUN
ijpds-4738	6	5	is	be	AUX
ijpds-4738	6	6	essential	essential	ADJ
ijpds-4738	6	7	whenever	whenever	SCONJ
ijpds-4738	6	8	an	an	DET
ijpds-4738	6	9	analytical	analytical	ADJ
ijpds-4738	6	10	method	method	NOUN
ijpds-4738	6	11	is	be	AUX
ijpds-4738	6	12	used	use	VERB
ijpds-4738	6	13	to	to	PART
ijpds-4738	6	14	generate	generate	VERB
ijpds-4738	6	15	results	result	NOUN
ijpds-4738	6	16	for	for	ADP
ijpds-4738	6	17	an	an	DET
ijpds-4738	6	18	array	array	NOUN
ijpds-4738	6	19	of	of	ADP
ijpds-4738	6	20	samples	sample	NOUN
ijpds-4738	6	21	related	relate	VERB
ijpds-4738	6	22	to	to	ADP
ijpds-4738	6	23	medicine	medicine	NOUN
ijpds-4738	6	24	.	.	PUNCT
ijpds-4738	7	1	in	in	ADP
ijpds-4738	7	2	the	the	DET
ijpds-4738	7	3	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	7	4	sector	sector	NOUN
ijpds-4738	7	5	,	,	PUNCT
ijpds-4738	7	6	good	good	ADJ
ijpds-4738	7	7	manufacturing	manufacturing	NOUN
ijpds-4738	7	8	practice	practice	NOUN
ijpds-4738	7	9	(	(	PUNCT
ijpds-4738	7	10	gmp	gmp	PROPN
ijpds-4738	7	11	)	)	PUNCT
ijpds-4738	7	12	rules	rule	NOUN
ijpds-4738	7	13	and	and	CCONJ
ijpds-4738	7	14	good	good	ADJ
ijpds-4738	7	15	laboratory	laboratory	NOUN
ijpds-4738	7	16	practices	practice	NOUN
ijpds-4738	7	17	(	(	PUNCT
ijpds-4738	7	18	glp	glp	NOUN
ijpds-4738	7	19	)	)	PUNCT
ijpds-4738	7	20	are	be	AUX
ijpds-4738	7	21	adhered	adhere	VERB
ijpds-4738	7	22	to	to	ADP
ijpds-4738	7	23	by	by	ADP
ijpds-4738	7	24	means	mean	NOUN
ijpds-4738	7	25	of	of	ADP
ijpds-4738	7	26	defined	define	VERB
ijpds-4738	7	27	validation	validation	NOUN
ijpds-4738	7	28	policies	policy	NOUN
ijpds-4738	7	29	,	,	PUNCT
ijpds-4738	7	30	forms	form	NOUN
ijpds-4738	7	31	of	of	ADP
ijpds-4738	7	32	validation	validation	NOUN
ijpds-4738	7	33	,	,	PUNCT
ijpds-4738	7	34	and	and	CCONJ
ijpds-4738	7	35	validation	validation	NOUN
ijpds-4738	7	36	criteria	criterion	NOUN
ijpds-4738	7	37	.	.	PUNCT
ijpds-4738	8	1	validation	validation	NOUN
ijpds-4738	8	2	is	be	AUX
ijpds-4738	8	3	crucial	crucial	ADJ
ijpds-4738	8	4	to	to	ADP
ijpds-4738	8	5	the	the	DET
ijpds-4738	8	6	efficient	efficient	ADJ
ijpds-4738	8	7	operation	operation	NOUN
ijpds-4738	8	8	of	of	ADP
ijpds-4738	8	9	the	the	DET
ijpds-4738	8	10	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	8	11	sector	sector	NOUN
ijpds-4738	8	12	.	.	PUNCT
ijpds-4738	9	1	validation	validation	NOUN
ijpds-4738	9	2	was	be	AUX
ijpds-4738	9	3	done	do	VERB
ijpds-4738	9	4	everywhere	everywhere	ADV
ijpds-4738	9	5	,	,	PUNCT
ijpds-4738	9	6	from	from	ADP
ijpds-4738	9	7	the	the	DET
ijpds-4738	9	8	raw	raw	ADJ
ijpds-4738	9	9	material	material	NOUN
ijpds-4738	9	10	to	to	ADP
ijpds-4738	9	11	the	the	DET
ijpds-4738	9	12	final	final	ADJ
ijpds-4738	9	13	,	,	PUNCT
ijpds-4738	9	14	stable	stable	ADJ
ijpds-4738	9	15	state	state	NOUN
ijpds-4738	9	16	.	.	PUNCT
ijpds-4738	10	1	the	the	DET
ijpds-4738	10	2	procedure	procedure	NOUN
ijpds-4738	10	3	was	be	AUX
ijpds-4738	10	4	appropriately	appropriately	ADV
ijpds-4738	10	5	designed	design	VERB
ijpds-4738	10	6	,	,	PUNCT
ijpds-4738	10	7	and	and	CCONJ
ijpds-4738	10	8	the	the	DET
ijpds-4738	10	9	validation	validation	NOUN
ijpds-4738	10	10	parameters	parameter	NOUN
ijpds-4738	10	11	—	—	PUNCT
ijpds-4738	10	12	specificity	specificity	NOUN
ijpds-4738	10	13	,	,	PUNCT
ijpds-4738	10	14	accuracy	accuracy	NOUN
ijpds-4738	10	15	,	,	PUNCT
ijpds-4738	10	16	quantitation	quantitation	NOUN
ijpds-4738	10	17	,	,	PUNCT
ijpds-4738	10	18	ruggedness	ruggedness	NOUN
ijpds-4738	10	19	,	,	PUNCT
ijpds-4738	10	20	robustness	robustness	NOUN
ijpds-4738	10	21	,	,	PUNCT
ijpds-4738	10	22	and	and	CCONJ
ijpds-4738	10	23	system	system	NOUN
ijpds-4738	10	24	appropriateness	appropriateness	NOUN
ijpds-4738	10	25	testing	testing	NOUN
ijpds-4738	10	26	—	—	PUNCT
ijpds-4738	10	27	are	be	AUX
ijpds-4738	10	28	specified	specify	VERB
ijpds-4738	10	29	in	in	ADP
ijpds-4738	10	30	terms	term	NOUN
ijpds-4738	10	31	of	of	ADP
ijpds-4738	10	32	limit	limit	NOUN
ijpds-4738	10	33	of	of	ADP
ijpds-4738	10	34	detection	detection	NOUN
ijpds-4738	10	35	(	(	PUNCT
ijpds-4738	10	36	lod	lod	PROPN
ijpds-4738	10	37	)	)	PUNCT
ijpds-4738	10	38	,	,	PUNCT
ijpds-4738	10	39	limit	limit	NOUN
ijpds-4738	10	40	of	of	ADP
ijpds-4738	10	41	quantitation	quantitation	NOUN
ijpds-4738	10	42	(	(	PUNCT
ijpds-4738	10	43	loq	loq	PROPN
ijpds-4738	10	44	)	)	PUNCT
ijpds-4738	10	45	,	,	PUNCT
ijpds-4738	10	46	robustness	robustness	NOUN
ijpds-4738	10	47	,	,	PUNCT
ijpds-4738	10	48	and	and	CCONJ
ijpds-4738	10	49	ruggedness	ruggedness	NOUN
ijpds-4738	10	50	with	with	ADP
ijpds-4738	10	51	reference	reference	NOUN
ijpds-4738	10	52	to	to	ADP
ijpds-4738	10	53	specific	specific	ADJ
ijpds-4738	10	54	drug	drug	NOUN
ijpds-4738	10	55	examples	example	NOUN
ijpds-4738	10	56	.	.	PUNCT
ijpds-4738	11	1	both	both	CCONJ
ijpds-4738	11	2	the	the	DET
ijpds-4738	11	3	methodology	methodology	NOUN
ijpds-4738	11	4	and	and	CCONJ
ijpds-4738	11	5	evaluation	evaluation	NOUN
ijpds-4738	11	6	of	of	ADP
ijpds-4738	11	7	stability	stability	NOUN
ijpds-4738	11	8	make	make	VERB
ijpds-4738	11	9	use	use	NOUN
ijpds-4738	11	10	of	of	ADP
ijpds-4738	11	11	all	all	DET
ijpds-4738	11	12	the	the	DET
ijpds-4738	11	13	validation	validation	NOUN
ijpds-4738	11	14	parameters	parameter	NOUN
ijpds-4738	11	15	.	.	PUNCT
ijpds-4738	12	1	key	key	ADJ
ijpds-4738	12	2	words	word	NOUN
ijpds-4738	12	3	:	:	PUNCT
ijpds-4738	12	4	analytical	analytical	ADJ
ijpds-4738	12	5	validation	validation	NOUN
ijpds-4738	12	6	,	,	PUNCT
ijpds-4738	12	7	method	method	NOUN
ijpds-4738	12	8	development	development	NOUN
ijpds-4738	12	9	,	,	PUNCT
ijpds-4738	12	10	validation	validation	NOUN
ijpds-4738	12	11	on	on	ADP
ijpds-4738	12	12	hplc	hplc	NOUN
ijpds-4738	12	13	,	,	PUNCT
ijpds-4738	12	14	separation	separation	NOUN
ijpds-4738	12	15	technique	technique	NOUN
ijpds-4738	12	16	,	,	PUNCT
ijpds-4738	12	17	various	various	ADJ
ijpds-4738	12	18	parameters	parameter	NOUN
ijpds-4738	12	19	hese	hese	VERB
ijpds-4738	12	20	drugs	drug	NOUN
ijpds-4738	12	21	may	may	AUX
ijpds-4738	12	22	be	be	AUX
ijpds-4738	12	23	entirely	entirely	ADV
ijpds-4738	12	24	new	new	ADJ
ijpds-4738	12	25	or	or	CCONJ
ijpds-4738	12	26	partially	partially	ADV
ijpds-4738	12	27	structurally	structurally	ADV
ijpds-4738	12	28	modified	modify	VERB
ijpds-4738	12	29	versions	version	NOUN
ijpds-4738	12	30	of	of	ADP
ijpds-4738	12	31	ones	one	NOUN
ijpds-4738	12	32	currently	currently	ADV
ijpds-4738	12	33	on	on	ADP
ijpds-4738	12	34	the	the	DET
ijpds-4738	12	35	market	market	NOUN
ijpds-4738	12	36	.	.	PUNCT
ijpds-4738	13	1	the	the	DET
ijpds-4738	13	2	aim	aim	NOUN
ijpds-4738	13	3	of	of	ADP
ijpds-4738	13	4	every	every	DET
ijpds-4738	13	5	analytical	analytical	ADJ
ijpds-4738	13	6	measurement	measurement	NOUN
ijpds-4738	13	7	is	be	AUX
ijpds-4738	13	8	to	to	PART
ijpds-4738	13	9	generate	generate	VERB
ijpds-4738	13	10	data	datum	NOUN
ijpds-4738	13	11	that	that	PRON
ijpds-4738	13	12	is	be	AUX
ijpds-4738	13	13	consistent	consistent	ADJ
ijpds-4738	13	14	,	,	PUNCT
ijpds-4738	13	15	accurate	accurate	ADJ
ijpds-4738	13	16	,	,	PUNCT
ijpds-4738	13	17	and	and	CCONJ
ijpds-4738	13	18	reliable	reliable	ADJ
ijpds-4738	13	19	.	.	PUNCT
ijpds-4738	14	1	validated	validate	VERB
ijpds-4738	14	2	analytical	analytical	ADJ
ijpds-4738	14	3	methods	method	NOUN
ijpds-4738	14	4	are	be	AUX
ijpds-4738	14	5	necessary	necessary	ADJ
ijpds-4738	14	6	to	to	PART
ijpds-4738	14	7	do	do	VERB
ijpds-4738	14	8	this	this	PRON
ijpds-4738	14	9	.	.	PUNCT
ijpds-4738	15	1	any	any	DET
ijpds-4738	15	2	legitimate	legitimate	ADJ
ijpds-4738	15	3	analytical	analytical	ADJ
ijpds-4738	15	4	approach	approach	NOUN
ijpds-4738	15	5	must	must	AUX
ijpds-4738	15	6	include	include	VERB
ijpds-4738	15	7	a	a	DET
ijpds-4738	15	8	means	mean	NOUN
ijpds-4738	15	9	of	of	ADP
ijpds-4738	15	10	assessing	assess	VERB
ijpds-4738	15	11	the	the	DET
ijpds-4738	15	12	precision	precision	NOUN
ijpds-4738	15	13	,	,	PUNCT
ijpds-4738	15	14	dependability	dependability	NOUN
ijpds-4738	15	15	,	,	PUNCT
ijpds-4738	15	16	and	and	CCONJ
ijpds-4738	15	17	uniformity	uniformity	NOUN
ijpds-4738	15	18	of	of	ADP
ijpds-4738	15	19	the	the	DET
ijpds-4738	15	20	statistical	statistical	ADJ
ijpds-4738	15	21	investigation	investigation	NOUN
ijpds-4738	15	22	utilizing	utilize	VERB
ijpds-4738	15	23	its	its	PRON
ijpds-4738	15	24	findings	finding	NOUN
ijpds-4738	15	25	of	of	ADP
ijpds-4738	15	26	method	method	NOUN
ijpds-4738	15	27	validation	validation	NOUN
ijpds-4738	15	28	.	.	PUNCT
ijpds-4738	16	1	furthermore	furthermore	ADV
ijpds-4738	16	2	,	,	PUNCT
ijpds-4738	16	3	the	the	DET
ijpds-4738	16	4	validation	validation	NOUN
ijpds-4738	16	5	of	of	ADP
ijpds-4738	16	6	analytical	analytical	ADJ
ijpds-4738	16	7	techniques	technique	NOUN
ijpds-4738	16	8	is	be	AUX
ijpds-4738	16	9	a	a	DET
ijpds-4738	16	10	must	must	NOUN
ijpds-4738	16	11	around	around	ADP
ijpds-4738	16	12	numerous	numerous	ADJ
ijpds-4738	16	13	laws	law	NOUN
ijpds-4738	16	14	in	in	ADP
ijpds-4738	16	15	addition	addition	NOUN
ijpds-4738	16	16	to	to	ADP
ijpds-4738	16	17	criteria	criterion	NOUN
ijpds-4738	16	18	pertaining	pertain	VERB
ijpds-4738	16	19	to	to	ADP
ijpds-4738	16	20	facilities	facility	NOUN
ijpds-4738	16	21	.	.	PUNCT
ijpds-4738	17	1	the	the	DET
ijpds-4738	17	2	date	date	NOUN
ijpds-4738	17	3	a	a	DET
ijpds-4738	17	4	medication	medication	NOUN
ijpds-4738	17	5	is	be	AUX
ijpds-4738	17	6	added	add	VERB
ijpds-4738	17	7	to	to	ADP
ijpds-4738	17	8	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	17	9	protocols	protocol	NOUN
ijpds-4738	17	10	and	and	CCONJ
ijpds-4738	17	11	the	the	DET
ijpds-4738	17	12	moment	moment	NOUN
ijpds-4738	17	13	it	it	PRON
ijpds-4738	17	14	was	be	AUX
ijpds-4738	17	15	initially	initially	ADV
ijpds-4738	17	16	made	make	VERB
ijpds-4738	17	17	available	available	ADJ
ijpds-4738	17	18	to	to	ADP
ijpds-4738	17	19	consumers	consumer	NOUN
ijpds-4738	17	20	usually	usually	ADV
ijpds-4738	17	21	coincide	coincide	VERB
ijpds-4738	17	22	[	[	X
ijpds-4738	17	23	1	1	NUM
ijpds-4738	17	24	]	]	PUNCT
ijpds-4738	17	25	.	.	PUNCT
ijpds-4738	18	1	in	in	ADP
ijpds-4738	18	2	such	such	ADJ
ijpds-4738	18	3	circumstances	circumstance	NOUN
ijpds-4738	18	4	,	,	PUNCT
ijpds-4738	18	5	the	the	DET
ijpds-4738	18	6	pharmacopoeias	pharmacopoeia	NOUN
ijpds-4738	18	7	could	could	AUX
ijpds-4738	18	8	not	not	PART
ijpds-4738	18	9	have	have	AUX
ijpds-4738	18	10	specified	specify	VERB
ijpds-4738	18	11	the	the	DET
ijpds-4738	18	12	requirements	requirement	NOUN
ijpds-4738	18	13	and	and	CCONJ
ijpds-4738	18	14	testing	testing	NOUN
ijpds-4738	18	15	methodologies	methodology	NOUN
ijpds-4738	18	16	for	for	ADP
ijpds-4738	18	17	these	these	DET
ijpds-4738	18	18	drugs	drug	NOUN
ijpds-4738	18	19	.	.	PUNCT
ijpds-4738	19	1	thus	thus	ADV
ijpds-4738	19	2	,	,	PUNCT
ijpds-4738	19	3	it	it	PRON
ijpds-4738	19	4	may	may	AUX
ijpds-4738	19	5	be	be	AUX
ijpds-4738	19	6	possible	possible	ADJ
ijpds-4738	19	7	to	to	PART
ijpds-4738	19	8	develop	develop	VERB
ijpds-4738	19	9	fresher	fresh	ADJ
ijpds-4738	19	10	analytical	analytical	ADJ
ijpds-4738	19	11	methods	method	NOUN
ijpds-4738	19	12	for	for	ADP
ijpds-4738	19	13	these	these	DET
ijpds-4738	19	14	drugs	drug	NOUN
ijpds-4738	19	15	.	.	PUNCT
ijpds-4738	20	1	in	in	ADP
ijpds-4738	20	2	the	the	DET
ijpds-4738	20	3	process	process	NOUN
ijpds-4738	20	4	of	of	ADP
ijpds-4738	20	5	finding	finding	NOUN
ijpds-4738	20	6	,	,	PUNCT
ijpds-4738	20	7	developing	developing	NOUN
ijpds-4738	20	8	,	,	PUNCT
ijpds-4738	20	9	and	and	CCONJ
ijpds-4738	20	10	producing	produce	VERB
ijpds-4738	20	11	medications	medication	NOUN
ijpds-4738	20	12	,	,	PUNCT
ijpds-4738	20	13	analytical	analytical	ADJ
ijpds-4738	20	14	methods	method	NOUN
ijpds-4738	20	15	are	be	AUX
ijpds-4738	20	16	crucial	crucial	ADJ
ijpds-4738	20	17	.	.	PUNCT
ijpds-4738	21	1	drug	drug	NOUN
ijpds-4738	21	2	combination	combination	NOUN
ijpds-4738	21	3	products	product	NOUN
ijpds-4738	21	4	,	,	PUNCT
ijpds-4738	21	5	also	also	ADV
ijpds-4738	21	6	known	know	VERB
ijpds-4738	21	7	as	as	ADP
ijpds-4738	21	8	combination	combination	NOUN
ijpds-4738	21	9	products	product	NOUN
ijpds-4738	21	10	,	,	PUNCT
ijpds-4738	21	11	combine	combine	VERB
ijpds-4738	21	12	the	the	DET
ijpds-4738	21	13	therapeutic	therapeutic	ADJ
ijpds-4738	21	14	benefits	benefit	NOUN
ijpds-4738	21	15	of	of	ADP
ijpds-4738	21	16	two	two	NUM
ijpds-4738	21	17	or	or	CCONJ
ijpds-4738	21	18	more	more	ADJ
ijpds-4738	21	19	medications	medication	NOUN
ijpds-4738	21	20	into	into	ADP
ijpds-4738	21	21	a	a	DET
ijpds-4738	21	22	single	single	ADJ
ijpds-4738	21	23	item	item	NOUN
ijpds-4738	21	24	in	in	ADP
ijpds-4738	21	25	order	order	NOUN
ijpds-4738	21	26	to	to	PART
ijpds-4738	21	27	fulfil	fulfil	VERB
ijpds-4738	21	28	the	the	DET
ijpds-4738	21	29	needs	need	NOUN
ijpds-4738	21	30	of	of	ADP
ijpds-4738	21	31	individuals	individual	NOUN
ijpds-4738	21	32	whose	whose	DET
ijpds-4738	21	33	work	work	NOUN
ijpds-4738	21	34	is	be	AUX
ijpds-4738	21	35	not	not	PART
ijpds-4738	21	36	formerly	formerly	ADV
ijpds-4738	21	37	treated	treat	VERB
ijpds-4738	21	38	by	by	ADP
ijpds-4738	21	39	them	they	PRON
ijpds-4738	21	40	.	.	PUNCT
ijpds-4738	22	1	this	this	PRON
ijpds-4738	22	2	requires	require	VERB
ijpds-4738	22	3	the	the	DET
ijpds-4738	22	4	invention	invention	NOUN
ijpds-4738	22	5	and	and	CCONJ
ijpds-4738	22	6	development	development	NOUN
ijpds-4738	22	7	of	of	ADP
ijpds-4738	22	8	analytical	analytical	ADJ
ijpds-4738	22	9	methods	method	NOUN
ijpds-4738	22	10	.	.	PUNCT
ijpds-4738	23	1	the	the	DET
ijpds-4738	23	2	analytical	analytical	ADJ
ijpds-4738	23	3	chemist	chemist	NOUN
ijpds-4738	23	4	in	in	ADP
ijpds-4738	23	5	charge	charge	NOUN
ijpds-4738	23	6	of	of	ADP
ijpds-4738	23	7	creating	create	VERB
ijpds-4738	23	8	and	and	CCONJ
ijpds-4738	23	9	verifying	verifying	NOUN
ijpds-4738	23	10	access	access	NOUN
ijpds-4738	23	11	this	this	DET
ijpds-4738	23	12	article	article	NOUN
ijpds-4738	23	13	online	online	ADV
ijpds-4738	23	14	received	receive	VERB
ijpds-4738	23	15	–	–	PUNCT
ijpds-4738	23	16	20th	20th	ADJ
ijpds-4738	23	17	july	july	PROPN
ijpds-4738	23	18	2024	2024	NUM
ijpds-4738	23	19	initial	initial	ADJ
ijpds-4738	23	20	review	review	NOUN
ijpds-4738	23	21	–	–	PUNCT
ijpds-4738	23	22	28th	28th	ADJ
ijpds-4738	23	23	september	september	PROPN
ijpds-4738	23	24	2024	2024	NUM
ijpds-4738	23	25	accepted	accept	VERB
ijpds-4738	23	26	–	–	PUNCT
ijpds-4738	23	27	28th	28th	ADJ
ijpds-4738	23	28	october	october	NOUN
ijpds-4738	23	29	2024	2024	NUM
ijpds-4738	23	30	quick	quick	ADJ
ijpds-4738	23	31	response	response	NOUN
ijpds-4738	23	32	code	code	NOUN
ijpds-4738	23	33	analytical	analytical	ADJ
ijpds-4738	23	34	procedures	procedure	NOUN
ijpds-4738	23	35	may	may	AUX
ijpds-4738	23	36	face	face	VERB
ijpds-4738	23	37	significant	significant	ADJ
ijpds-4738	23	38	challenges	challenge	NOUN
ijpds-4738	23	39	as	as	ADP
ijpds-4738	23	40	a	a	DET
ijpds-4738	23	41	result	result	NOUN
ijpds-4738	23	42	of	of	ADP
ijpds-4738	23	43	these	these	DET
ijpds-4738	23	44	combination	combination	NOUN
ijpds-4738	23	45	products	product	NOUN
ijpds-4738	23	46	.	.	PUNCT
ijpds-4738	24	1	to	to	PART
ijpds-4738	24	2	verify	verify	VERB
ijpds-4738	24	3	the	the	DET
ijpds-4738	24	4	identification	identification	NOUN
ijpds-4738	24	5	,	,	PUNCT
ijpds-4738	24	6	purity	purity	NOUN
ijpds-4738	24	7	,	,	PUNCT
ijpds-4738	24	8	potency	potency	NOUN
ijpds-4738	24	9	,	,	PUNCT
ijpds-4738	24	10	and	and	CCONJ
ijpds-4738	24	11	effectiveness	effectiveness	NOUN
ijpds-4738	24	12	of	of	ADP
ijpds-4738	24	13	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	24	14	items	item	NOUN
ijpds-4738	24	15	,	,	PUNCT
ijpds-4738	24	16	regulatory	regulatory	ADJ
ijpds-4738	24	17	laboratories	laboratory	NOUN
ijpds-4738	24	18	employ	employ	VERB
ijpds-4738	24	19	legitimate	legitimate	ADJ
ijpds-4738	24	20	test	test	NOUN
ijpds-4738	24	21	techniques	technique	NOUN
ijpds-4738	24	22	that	that	PRON
ijpds-4738	24	23	are	be	AUX
ijpds-4738	24	24	produced	produce	VERB
ijpds-4738	24	25	by	by	ADP
ijpds-4738	24	26	these	these	DET
ijpds-4738	24	27	procedures	procedure	NOUN
ijpds-4738	24	28	.	.	PUNCT
ijpds-4738	25	1	identification	identification	NOUN
ijpds-4738	25	2	and	and	CCONJ
ijpds-4738	25	3	measurement	measurement	NOUN
ijpds-4738	25	4	of	of	ADP
ijpds-4738	25	5	contaminants	contaminant	NOUN
ijpds-4738	25	6	belong	belong	VERB
ijpds-4738	25	7	to	to	ADP
ijpds-4738	25	8	one	one	NUM
ijpds-4738	25	9	of	of	ADP
ijpds-4738	25	10	the	the	DET
ijpds-4738	25	11	most	most	ADV
ijpds-4738	25	12	crucial	crucial	ADJ
ijpds-4738	25	13	steps	step	NOUN
ijpds-4738	25	14	in	in	ADP
ijpds-4738	25	15	creating	create	VERB
ijpds-4738	25	16	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	25	17	procedures	procedure	NOUN
ijpds-4738	25	18	for	for	ADP
ijpds-4738	25	19	quality	quality	NOUN
ijpds-4738	25	20	and	and	CCONJ
ijpds-4738	25	21	safety	safety	NOUN
ijpds-4738	25	22	[	[	X
ijpds-4738	25	23	1	1	NUM
ijpds-4738	25	24	]	]	PUNCT
ijpds-4738	25	25	.	.	PUNCT
ijpds-4738	26	1			X
ijpds-4738	26	2	basic	basic	ADJ
ijpds-4738	26	3	criteria	criterion	NOUN
ijpds-4738	26	4	for	for	ADP
ijpds-4738	26	5	new	new	ADJ
ijpds-4738	26	6	method	method	NOUN
ijpds-4738	26	7	development	development	NOUN
ijpds-4738	26	8	for	for	ADP
ijpds-4738	26	9	drug	drug	NOUN
ijpds-4738	26	10	analysis	analysis	NOUN
ijpds-4738	26	11	a.	a.	NOUN
ijpds-4738	26	12	the	the	DET
ijpds-4738	26	13	medication	medication	NOUN
ijpds-4738	26	14	is	be	AUX
ijpds-4738	26	15	unlikely	unlikely	ADJ
ijpds-4738	26	16	to	to	PART
ijpds-4738	26	17	be	be	AUX
ijpds-4738	26	18	listed	list	VERB
ijpds-4738	26	19	as	as	ADP
ijpds-4738	26	20	official	official	NOUN
ijpds-4738	26	21	in	in	ADP
ijpds-4738	26	22	any	any	DET
ijpds-4738	26	23	pharmacopoeias	pharmacopoeia	NOUN
ijpds-4738	26	24	.	.	PUNCT
ijpds-4738	27	1	b.	b.	PROPN
ijpds-4738	27	2	analytical	analytical	ADJ
ijpds-4738	27	3	methods	method	NOUN
ijpds-4738	27	4	for	for	ADP
ijpds-4738	27	5	a	a	DET
ijpds-4738	27	6	medicine	medicine	NOUN
ijpds-4738	27	7	may	may	AUX
ijpds-4738	27	8	not	not	PART
ijpds-4738	27	9	be	be	AUX
ijpds-4738	27	10	permitted	permit	VERB
ijpds-4738	27	11	in	in	ADP
ijpds-4738	27	12	publishing	publish	VERB
ijpds-4738	27	13	under	under	ADP
ijpds-4738	27	14	any	any	DET
ijpds-4738	27	15	specific	specific	ADJ
ijpds-4738	27	16	creation	creation	NOUN
ijpds-4738	27	17	aspect	aspect	NOUN
ijpds-4738	27	18	due	due	ADP
ijpds-4738	27	19	to	to	PART
ijpds-4738	27	20	interference	interference	VERB
ijpds-4738	27	21	through	through	ADP
ijpds-4738	27	22	formulation	formulation	NOUN
ijpds-4738	27	23	excipients	excipient	NOUN
ijpds-4738	27	24	.	.	PUNCT
ijpds-4738	28	1	c.	c.	NOUN
ijpds-4738	28	2	due	due	ADP
ijpds-4738	28	3	to	to	ADP
ijpds-4738	28	4	patent	patent	NOUN
ijpds-4738	28	5	laws	law	NOUN
ijpds-4738	28	6	,	,	PUNCT
ijpds-4738	28	7	appropriate	appropriate	ADJ
ijpds-4738	28	8	analytical	analytical	ADJ
ijpds-4738	28	9	techniques	technique	NOUN
ijpds-4738	28	10	for	for	ADP
ijpds-4738	28	11	the	the	DET
ijpds-4738	28	12	drug	drug	NOUN
ijpds-4738	28	13	could	could	AUX
ijpds-4738	28	14	not	not	PART
ijpds-4738	28	15	be	be	AUX
ijpds-4738	28	16	accessible	accessible	ADJ
ijpds-4738	28	17	.	.	PUNCT
ijpds-4738	29	1	d.	d.	PROPN
ijpds-4738	29	2	there	there	PRON
ijpds-4738	29	3	could	could	AUX
ijpds-4738	29	4	not	not	PART
ijpds-4738	29	5	be	be	AUX
ijpds-4738	29	6	adequate	adequate	ADJ
ijpds-4738	29	7	analytical	analytical	ADJ
ijpds-4738	29	8	techniques	technique	NOUN
ijpds-4738	29	9	obtainable	obtainable	ADJ
ijpds-4738	29	10	for	for	ADP
ijpds-4738	29	11	assessing	assess	VERB
ijpds-4738	29	12	the	the	DET
ijpds-4738	29	13	drug	drug	NOUN
ijpds-4738	29	14	through	through	ADP
ijpds-4738	29	15	your	your	PRON
ijpds-4738	29	16	system	system	NOUN
ijpds-4738	29	17	.	.	PUNCT
ijpds-4738	30	1			X
ijpds-4738	30	2	various	various	ADJ
ijpds-4738	30	3	reasoning	reasoning	NOUN
ijpds-4738	30	4	for	for	ADP
ijpds-4738	30	5	analytical	analytical	ADJ
ijpds-4738	30	6	technique	technique	NOUN
ijpds-4738	30	7	analytical	analytical	ADJ
ijpds-4738	30	8	techniques	technique	NOUN
ijpds-4738	30	9	have	have	AUX
ijpds-4738	30	10	progressed	progress	VERB
ijpds-4738	30	11	,	,	PUNCT
ijpds-4738	30	12	and	and	CCONJ
ijpds-4738	30	13	during	during	ADP
ijpds-4738	30	14	analytical	analytical	ADJ
ijpds-4738	30	15	analyses	analysis	NOUN
ijpds-4738	30	16	,	,	PUNCT
ijpds-4738	30	17	hplc	hplc	NOUN
ijpds-4738	30	18	procedures	procedure	NOUN
ijpds-4738	30	19	produce	produce	VERB
ijpds-4738	30	20	vast	vast	ADJ
ijpds-4738	30	21	amounts	amount	NOUN
ijpds-4738	30	22	of	of	ADP
ijpds-4738	30	23	data	datum	NOUN
ijpds-4738	30	24	.	.	PUNCT
ijpds-4738	31	1	even	even	ADV
ijpds-4738	31	2	though	though	SCONJ
ijpds-4738	31	3	hplc	hplc	NOUN
ijpds-4738	31	4	is	be	AUX
ijpds-4738	31	5	a	a	DET
ijpds-4738	31	6	flexible	flexible	ADJ
ijpds-4738	31	7	separation	separation	NOUN
ijpds-4738	31	8	method	method	NOUN
ijpds-4738	31	9	with	with	ADP
ijpds-4738	31	10	many	many	ADJ
ijpds-4738	31	11	_	_	PUNCT
ijpds-4738	32	1	_	_	PUNCT
ijpds-4738	33	1	_	_	PUNCT
ijpds-4738	34	1	_	_	PUNCT
ijpds-4738	35	1	_	_	PUNCT
ijpds-4738	36	1	_	_	PUNCT
ijpds-4738	37	1	_	_	PUNCT
ijpds-4738	38	1	_	_	PUNCT
ijpds-4738	39	1	_	_	PUNCT
ijpds-4738	40	1	_	_	PUNCT
ijpds-4738	41	1	_	_	PUNCT
ijpds-4738	42	1	_	_	PUNCT
ijpds-4738	43	1	_	_	PUNCT
ijpds-4738	44	1	_	_	PUNCT
ijpds-4738	45	1	_	_	PUNCT
ijpds-4738	46	1	_	_	PUNCT
ijpds-4738	47	1	_	_	PUNCT
ijpds-4738	48	1	_	_	PUNCT
ijpds-4738	49	1	_	_	PUNCT
ijpds-4738	50	1	_	_	PUNCT
ijpds-4738	51	1	_	_	PUNCT
ijpds-4738	52	1	_	_	PUNCT
ijpds-4738	53	1	_	_	PUNCT
ijpds-4738	54	1	_	_	PUNCT
ijpds-4738	55	1	_	_	PUNCT
ijpds-4738	56	1	_	_	PUNCT
ijpds-4738	57	1	_	_	PUNCT
ijpds-4738	58	1	_	_	PUNCT
ijpds-4738	59	1	_	_	PUNCT
ijpds-4738	60	1	_	_	PUNCT
ijpds-4738	61	1	_	_	PUNCT
ijpds-4738	62	1	_	_	PUNCT
ijpds-4738	63	1	_	_	PUNCT
ijpds-4738	64	1	_	_	PUNCT
ijpds-4738	65	1	_	_	PUNCT
ijpds-4738	66	1	_	_	PUNCT
ijpds-4738	67	1	_	_	PUNCT
ijpds-4738	68	1	_	_	PUNCT
ijpds-4738	69	1	_	_	PUNCT
ijpds-4738	70	1	_	_	PUNCT
ijpds-4738	71	1	_	_	PUNCT
ijpds-4738	72	1	_	_	PUNCT
ijpds-4738	73	1	_	_	PUNCT
ijpds-4738	74	1	_	_	PUNCT
ijpds-4738	75	1	_	_	PUNCT
ijpds-4738	76	1	_	_	PUNCT
ijpds-4738	77	1	_	_	PUNCT
ijpds-4738	78	1	_	_	PUNCT
ijpds-4738	79	1	_	_	PUNCT
ijpds-4738	80	1	_	_	PUNCT
ijpds-4738	80	2	correspondence	correspondence	NOUN
ijpds-4738	80	3	to	to	PART
ijpds-4738	80	4	:	:	PUNCT
ijpds-4738	80	5	rutik	rutik	PROPN
ijpds-4738	80	6	nitin	nitin	PROPN
ijpds-4738	80	7	patil	patil	PROPN
ijpds-4738	80	8	.	.	PUNCT
ijpds-4738	81	1	department	department	PROPN
ijpds-4738	81	2	of	of	ADP
ijpds-4738	81	3	quality	quality	NOUN
ijpds-4738	81	4	assurance	assurance	NOUN
ijpds-4738	81	5	,	,	PUNCT
ijpds-4738	81	6	a.r.a	a.r.a	ADJ
ijpds-4738	81	7	college	college	NOUN
ijpds-4738	81	8	of	of	ADP
ijpds-4738	81	9	pharmacy	pharmacy	NOUN
ijpds-4738	81	10	,	,	PUNCT
ijpds-4738	81	11	dhule	dhule	NOUN
ijpds-4738	81	12	,	,	PUNCT
ijpds-4738	81	13	india	india	PROPN
ijpds-4738	81	14	.	.	PUNCT
ijpds-4738	81	15	email	email	NOUN
ijpds-4738	81	16	:	:	PUNCT
ijpds-4738	81	17	rutik.patil57@gmail.com	rutik.patil57@gmail.com	PROPN
ijpds-4738	81	18	t	t	PROPN
ijpds-4738	81	19	mailto:rutik.patil57@gmail.com	mailto:rutik.patil57@gmail.com	X
ijpds-4738	81	20	patil	patil	PROPN
ijpds-4738	81	21	et	et	PROPN
ijpds-4738	81	22	al	al	PROPN
ijpds-4738	81	23	.	.	PROPN
ijpds-4738	82	1	analytical	analytical	ADJ
ijpds-4738	82	2	method	method	PROPN
ijpds-4738	82	3	development	development	NOUN
ijpds-4738	82	4	and	and	CCONJ
ijpds-4738	82	5	validation	validation	NOUN
ijpds-4738	82	6	online	online	ADJ
ijpds-4738	82	7	first	first	PROPN
ijpds-4738	82	8	indian	indian	PROPN
ijpds-4738	82	9	j	j	PROPN
ijpds-4738	82	10	pharm	pharm	PROPN
ijpds-4738	82	11	drug	drug	PROPN
ijpds-4738	82	12	studies	study	NOUN
ijpds-4738	82	13	|	|	ADV
ijpds-4738	82	14	2	2	NUM
ijpds-4738	82	15	uses	use	NOUN
ijpds-4738	82	16	,	,	PUNCT
ijpds-4738	82	17	its	its	PRON
ijpds-4738	82	18	many	many	ADJ
ijpds-4738	82	19	variables	variable	NOUN
ijpds-4738	82	20	,	,	PUNCT
ijpds-4738	82	21	which	which	PRON
ijpds-4738	82	22	must	must	AUX
ijpds-4738	82	23	be	be	AUX
ijpds-4738	82	24	precisely	precisely	ADV
ijpds-4738	82	25	adjusted	adjust	VERB
ijpds-4738	82	26	before	before	ADP
ijpds-4738	82	27	each	each	DET
ijpds-4738	82	28	run	run	NOUN
ijpds-4738	82	29	,	,	PUNCT
ijpds-4738	82	30	can	can	AUX
ijpds-4738	82	31	occasionally	occasionally	ADV
ijpds-4738	82	32	make	make	VERB
ijpds-4738	82	33	the	the	DET
ijpds-4738	82	34	procedure	procedure	NOUN
ijpds-4738	82	35	dangerous	dangerous	ADJ
ijpds-4738	82	36	.	.	PUNCT
ijpds-4738	83	1	consequently	consequently	ADV
ijpds-4738	83	2	,	,	PUNCT
ijpds-4738	83	3	it	it	PRON
ijpds-4738	83	4	becomes	become	VERB
ijpds-4738	83	5	imperative	imperative	ADJ
ijpds-4738	83	6	to	to	PART
ijpds-4738	83	7	comprehend	comprehend	VERB
ijpds-4738	83	8	these	these	DET
ijpds-4738	83	9	methods	method	NOUN
ijpds-4738	83	10	on	on	ADP
ijpds-4738	83	11	a	a	DET
ijpds-4738	83	12	deeper	deep	ADJ
ijpds-4738	83	13	level	level	NOUN
ijpds-4738	83	14	.	.	PUNCT
ijpds-4738	84	1	furthermore	furthermore	ADV
ijpds-4738	84	2	,	,	PUNCT
ijpds-4738	84	3	the	the	DET
ijpds-4738	84	4	process	process	NOUN
ijpds-4738	84	5	of	of	ADP
ijpds-4738	84	6	optimizing	optimize	VERB
ijpds-4738	84	7	multiple	multiple	ADJ
ijpds-4738	84	8	variables	variable	NOUN
ijpds-4738	84	9	that	that	PRON
ijpds-4738	84	10	need	need	VERB
ijpds-4738	84	11	to	to	PART
ijpds-4738	84	12	be	be	AUX
ijpds-4738	84	13	controlled	control	VERB
ijpds-4738	84	14	at	at	ADP
ijpds-4738	84	15	the	the	DET
ijpds-4738	84	16	same	same	ADJ
ijpds-4738	84	17	time	time	NOUN
ijpds-4738	84	18	in	in	ADP
ijpds-4738	84	19	order	order	NOUN
ijpds-4738	84	20	to	to	PART
ijpds-4738	84	21	achieve	achieve	VERB
ijpds-4738	84	22	the	the	DET
ijpds-4738	84	23	required	require	VERB
ijpds-4738	84	24	separations	separation	NOUN
ijpds-4738	84	25	,	,	PUNCT
ijpds-4738	84	26	such	such	ADJ
ijpds-4738	84	27	as	as	ADP
ijpds-4738	84	28	the	the	DET
ijpds-4738	84	29	mobile	mobile	ADJ
ijpds-4738	84	30	phase	phase	NOUN
ijpds-4738	84	31	's	's	PART
ijpds-4738	84	32	ph	ph	ADJ
ijpds-4738	84	33	,	,	PUNCT
ijpds-4738	84	34	buffer	buffer	NOUN
ijpds-4738	84	35	concentration	concentration	NOUN
ijpds-4738	84	36	,	,	PUNCT
ijpds-4738	84	37	rate	rate	NOUN
ijpds-4738	84	38	of	of	ADP
ijpds-4738	84	39	flow	flow	NOUN
ijpds-4738	84	40	,	,	PUNCT
ijpds-4738	84	41	column	column	NOUN
ijpds-4738	84	42	temperature	temperature	NOUN
ijpds-4738	84	43	,	,	PUNCT
ijpds-4738	84	44	detector	detector	NOUN
ijpds-4738	84	45	raise	raise	NOUN
ijpds-4738	84	46	length	length	NOUN
ijpds-4738	84	47	,	,	PUNCT
ijpds-4738	84	48	etc	etc	X
ijpds-4738	85	1	[	[	X
ijpds-4738	85	2	2	2	NUM
ijpds-4738	85	3	]	]	PUNCT
ijpds-4738	85	4	.	.	PUNCT
ijpds-4738	86	1	the	the	DET
ijpds-4738	86	2	chemometric	chemometric	ADJ
ijpds-4738	86	3	technique	technique	NOUN
ijpds-4738	86	4	is	be	AUX
ijpds-4738	86	5	highlighted	highlight	VERB
ijpds-4738	86	6	in	in	ADP
ijpds-4738	86	7	all	all	PRON
ijpds-4738	86	8	of	of	ADP
ijpds-4738	86	9	these	these	DET
ijpds-4738	86	10	studies	study	NOUN
ijpds-4738	86	11	as	as	ADP
ijpds-4738	86	12	a	a	DET
ijpds-4738	86	13	new	new	ADJ
ijpds-4738	86	14	instrument	instrument	NOUN
ijpds-4738	86	15	in	in	ADP
ijpds-4738	86	16	the	the	DET
ijpds-4738	86	17	arena	arena	NOUN
ijpds-4738	86	18	of	of	ADP
ijpds-4738	86	19	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	86	20	analysis	analysis	NOUN
ijpds-4738	86	21	.	.	PUNCT
ijpds-4738	87	1	the	the	DET
ijpds-4738	87	2	use	use	NOUN
ijpds-4738	87	3	of	of	ADP
ijpds-4738	87	4	laboratory	laboratory	NOUN
ijpds-4738	87	5	patterns	pattern	NOUN
ijpds-4738	87	6	to	to	PART
ijpds-4738	87	7	establish	establish	VERB
ijpds-4738	87	8	design	design	NOUN
ijpds-4738	87	9	spaces	space	NOUN
ijpds-4738	87	10	—	—	PUNCT
ijpds-4738	87	11	a	a	DET
ijpds-4738	87	12	crucial	crucial	ADJ
ijpds-4738	87	13	element	element	NOUN
ijpds-4738	87	14	of	of	ADP
ijpds-4738	87	15	the	the	DET
ijpds-4738	87	16	quality	quality	NOUN
ijpds-4738	87	17	with	with	ADP
ijpds-4738	87	18	the	the	DET
ijpds-4738	87	19	design	design	NOUN
ijpds-4738	87	20	approach	approach	NOUN
ijpds-4738	87	21	of	of	ADP
ijpds-4738	87	22	analytical	analytical	ADJ
ijpds-4738	87	23	methods	method	NOUN
ijpds-4738	87	24	—	—	PUNCT
ijpds-4738	87	25	was	be	AUX
ijpds-4738	87	26	recently	recently	ADV
ijpds-4738	87	27	covered	cover	VERB
ijpds-4738	87	28	by	by	ADP
ijpds-4738	87	29	rozet	rozet	NOUN
ijpds-4738	87	30	et	et	NOUN
ijpds-4738	87	31	al	al	PROPN
ijpds-4738	88	1	[	[	X
ijpds-4738	88	2	3	3	NUM
ijpds-4738	88	3	]	]	PUNCT
ijpds-4738	88	4	.	.	PUNCT
ijpds-4738	89	1	figure	figure	NOUN
ijpds-4738	89	2	1	1	NUM
ijpds-4738	89	3	:	:	PUNCT
ijpds-4738	89	4	life	life	NOUN
ijpds-4738	89	5	cycle	cycle	NOUN
ijpds-4738	89	6	of	of	ADP
ijpds-4738	89	7	the	the	DET
ijpds-4738	89	8	analytical	analytical	ADJ
ijpds-4738	89	9	method	method	NOUN
ijpds-4738	89	10	[	[	X
ijpds-4738	89	11	4	4	NUM
ijpds-4738	89	12	]	]	ADJ
ijpds-4738	89	13	objectives	objective	NOUN
ijpds-4738	89	14	:	:	PUNCT
ijpds-4738	89	15	1	1	X
ijpds-4738	89	16	.	.	X
ijpds-4738	89	17	development	development	NOUN
ijpds-4738	89	18	and	and	CCONJ
ijpds-4738	89	19	validation	validation	NOUN
ijpds-4738	89	20	of	of	ADP
ijpds-4738	89	21	analytical	analytical	ADJ
ijpds-4738	89	22	methods	method	NOUN
ijpds-4738	89	23	:	:	PUNCT
ijpds-4738	89	24	from	from	ADP
ijpds-4738	89	25	the	the	DET
ijpds-4738	89	26	formulation	formulation	NOUN
ijpds-4738	89	27	phase	phase	NOUN
ijpds-4738	89	28	all	all	DET
ijpds-4738	89	29	the	the	DET
ijpds-4738	89	30	way	way	NOUN
ijpds-4738	89	31	up	up	ADP
ijpds-4738	89	32	to	to	ADP
ijpds-4738	89	33	the	the	DET
ijpds-4738	89	34	manufacturing	manufacturing	NOUN
ijpds-4738	89	35	of	of	ADP
ijpds-4738	89	36	commercial	commercial	ADJ
ijpds-4738	89	37	batches	batch	NOUN
ijpds-4738	89	38	,	,	PUNCT
ijpds-4738	89	39	analytical	analytical	ADJ
ijpds-4738	89	40	techniques	technique	NOUN
ijpds-4738	89	41	are	be	AUX
ijpds-4738	89	42	essential	essential	ADJ
ijpds-4738	89	43	.	.	PUNCT
ijpds-4738	90	1	to	to	PART
ijpds-4738	90	2	make	make	VERB
ijpds-4738	90	3	sure	sure	ADJ
ijpds-4738	90	4	that	that	SCONJ
ijpds-4738	90	5	these	these	DET
ijpds-4738	90	6	techniques	technique	NOUN
ijpds-4738	90	7	yield	yield	VERB
ijpds-4738	90	8	accurate	accurate	ADJ
ijpds-4738	90	9	and	and	CCONJ
ijpds-4738	90	10	trustworthy	trustworthy	ADJ
ijpds-4738	90	11	findings	finding	NOUN
ijpds-4738	90	12	,	,	PUNCT
ijpds-4738	90	13	they	they	PRON
ijpds-4738	90	14	must	must	AUX
ijpds-4738	90	15	be	be	AUX
ijpds-4738	90	16	researched	research	VERB
ijpds-4738	90	17	and	and	CCONJ
ijpds-4738	90	18	verified	verify	VERB
ijpds-4738	90	19	.	.	PUNCT
ijpds-4738	91	1	2	2	X
ijpds-4738	91	2	.	.	X
ijpds-4738	91	3	importance	importance	NOUN
ijpds-4738	91	4	of	of	ADP
ijpds-4738	91	5	validation	validation	NOUN
ijpds-4738	91	6	:	:	PUNCT
ijpds-4738	91	7	validation	validation	NOUN
ijpds-4738	91	8	guarantees	guarantee	VERB
ijpds-4738	91	9	that	that	SCONJ
ijpds-4738	91	10	analytical	analytical	ADJ
ijpds-4738	91	11	procedures	procedure	NOUN
ijpds-4738	91	12	satisfy	satisfy	VERB
ijpds-4738	91	13	specified	specify	VERB
ijpds-4738	91	14	requirements	requirement	NOUN
ijpds-4738	91	15	for	for	ADP
ijpds-4738	91	16	system	system	NOUN
ijpds-4738	91	17	appropriateness	appropriateness	NOUN
ijpds-4738	91	18	,	,	PUNCT
ijpds-4738	91	19	ruggedness	ruggedness	NOUN
ijpds-4738	91	20	,	,	PUNCT
ijpds-4738	91	21	robustness	robustness	NOUN
ijpds-4738	91	22	,	,	PUNCT
ijpds-4738	91	23	limit	limit	NOUN
ijpds-4738	91	24	of	of	ADP
ijpds-4738	91	25	detection	detection	NOUN
ijpds-4738	91	26	(	(	PUNCT
ijpds-4738	91	27	lod	lod	PROPN
ijpds-4738	91	28	)	)	PUNCT
ijpds-4738	91	29	,	,	PUNCT
ijpds-4738	91	30	limit	limit	NOUN
ijpds-4738	91	31	of	of	ADP
ijpds-4738	91	32	quantitation	quantitation	NOUN
ijpds-4738	91	33	(	(	PUNCT
ijpds-4738	91	34	loq	loq	PROPN
ijpds-4738	91	35	)	)	PUNCT
ijpds-4738	91	36	,	,	PUNCT
ijpds-4738	91	37	accuracy	accuracy	NOUN
ijpds-4738	91	38	,	,	PUNCT
ijpds-4738	91	39	specificity	specificity	NOUN
ijpds-4738	91	40	,	,	PUNCT
ijpds-4738	91	41	and	and	CCONJ
ijpds-4738	91	42	precision	precision	NOUN
ijpds-4738	91	43	.	.	PUNCT
ijpds-4738	92	1	these	these	DET
ijpds-4738	92	2	criteria	criterion	NOUN
ijpds-4738	92	3	are	be	AUX
ijpds-4738	92	4	necessary	necessary	ADJ
ijpds-4738	92	5	to	to	PART
ijpds-4738	92	6	guarantee	guarantee	VERB
ijpds-4738	92	7	the	the	DET
ijpds-4738	92	8	quality	quality	NOUN
ijpds-4738	92	9	of	of	ADP
ijpds-4738	92	10	pharmaceuticals	pharmaceutical	NOUN
ijpds-4738	92	11	.	.	PUNCT
ijpds-4738	93	1	3	3	X
ijpds-4738	93	2	.	.	X
ijpds-4738	93	3	regulatory	regulatory	ADJ
ijpds-4738	93	4	bodies	body	NOUN
ijpds-4738	93	5	:	:	PUNCT
ijpds-4738	93	6	validation	validation	NOUN
ijpds-4738	93	7	procedures	procedure	NOUN
ijpds-4738	93	8	follow	follow	VERB
ijpds-4738	93	9	gmp	gmp	PROPN
ijpds-4738	93	10	guidelines	guideline	NOUN
ijpds-4738	93	11	and	and	CCONJ
ijpds-4738	93	12	are	be	AUX
ijpds-4738	93	13	recorded	record	VERB
ijpds-4738	93	14	.	.	PUNCT
ijpds-4738	94	1	in	in	ADP
ijpds-4738	94	2	order	order	NOUN
ijpds-4738	94	3	to	to	PART
ijpds-4738	94	4	guarantee	guarantee	VERB
ijpds-4738	94	5	the	the	DET
ijpds-4738	94	6	security	security	NOUN
ijpds-4738	94	7	,	,	PUNCT
ijpds-4738	94	8	effectiveness	effectiveness	NOUN
ijpds-4738	94	9	,	,	PUNCT
ijpds-4738	94	10	and	and	CCONJ
ijpds-4738	94	11	caliber	caliber	NOUN
ijpds-4738	94	12	of	of	ADP
ijpds-4738	94	13	their	their	PRON
ijpds-4738	94	14	goods	good	NOUN
ijpds-4738	94	15	,	,	PUNCT
ijpds-4738	94	16	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	94	17	companies	company	NOUN
ijpds-4738	94	18	must	must	AUX
ijpds-4738	94	19	abide	abide	VERB
ijpds-4738	94	20	by	by	ADP
ijpds-4738	94	21	these	these	DET
ijpds-4738	94	22	rules	rule	NOUN
ijpds-4738	94	23	.	.	PUNCT
ijpds-4738	95	1	4	4	X
ijpds-4738	95	2	.	.	X
ijpds-4738	95	3	stages	stage	NOUN
ijpds-4738	95	4	of	of	ADP
ijpds-4738	95	5	validation	validation	NOUN
ijpds-4738	95	6	:	:	PUNCT
ijpds-4738	95	7	testing	testing	NOUN
ijpds-4738	95	8	is	be	AUX
ijpds-4738	95	9	done	do	VERB
ijpds-4738	95	10	on	on	ADP
ijpds-4738	95	11	raw	raw	ADJ
ijpds-4738	95	12	materials	material	NOUN
ijpds-4738	95	13	and	and	CCONJ
ijpds-4738	95	14	final	final	ADJ
ijpds-4738	95	15	products	product	NOUN
ijpds-4738	95	16	in	in	ADP
ijpds-4738	95	17	every	every	DET
ijpds-4738	95	18	stage	stage	NOUN
ijpds-4738	95	19	of	of	ADP
ijpds-4738	95	20	the	the	DET
ijpds-4738	95	21	production	production	NOUN
ijpds-4738	95	22	method	method	NOUN
ijpds-4738	95	23	to	to	PART
ijpds-4738	95	24	ensure	ensure	VERB
ijpds-4738	95	25	their	their	PRON
ijpds-4738	95	26	stability	stability	NOUN
ijpds-4738	95	27	.	.	PUNCT
ijpds-4738	96	1	this	this	DET
ijpds-4738	96	2	all	all	ADV
ijpds-4738	96	3	-	-	PUNCT
ijpds-4738	96	4	encompassing	encompass	VERB
ijpds-4738	96	5	strategy	strategy	NOUN
ijpds-4738	96	6	guarantees	guarantee	VERB
ijpds-4738	96	7	that	that	SCONJ
ijpds-4738	96	8	the	the	DET
ijpds-4738	96	9	procedure	procedure	NOUN
ijpds-4738	96	10	is	be	AUX
ijpds-4738	96	11	validated	validate	VERB
ijpds-4738	96	12	and	and	CCONJ
ijpds-4738	96	13	satisfies	satisfy	VERB
ijpds-4738	96	14	necessary	necessary	ADJ
ijpds-4738	96	15	requirements	requirement	NOUN
ijpds-4738	96	16	.	.	PUNCT
ijpds-4738	97	1	5	5	X
ijpds-4738	97	2	.	.	X
ijpds-4738	97	3	method	method	PROPN
ijpds-4738	97	4	development	development	NOUN
ijpds-4738	97	5	:	:	PUNCT
ijpds-4738	97	6	in	in	ADP
ijpds-4738	97	7	order	order	NOUN
ijpds-4738	97	8	to	to	PART
ijpds-4738	97	9	assure	assure	VERB
ijpds-4738	97	10	that	that	SCONJ
ijpds-4738	97	11	analyses	analysis	NOUN
ijpds-4738	97	12	are	be	AUX
ijpds-4738	97	13	sensitive	sensitive	ADJ
ijpds-4738	97	14	,	,	PUNCT
ijpds-4738	97	15	selective	selective	ADJ
ijpds-4738	97	16	,	,	PUNCT
ijpds-4738	97	17	and	and	CCONJ
ijpds-4738	97	18	capable	capable	ADJ
ijpds-4738	97	19	of	of	ADP
ijpds-4738	97	20	reliably	reliably	ADV
ijpds-4738	97	21	delivering	deliver	VERB
ijpds-4738	97	22	accurate	accurate	ADJ
ijpds-4738	97	23	findings	finding	NOUN
ijpds-4738	97	24	under	under	ADP
ijpds-4738	97	25	a	a	DET
ijpds-4738	97	26	variety	variety	NOUN
ijpds-4738	97	27	of	of	ADP
ijpds-4738	97	28	the	the	DET
ijpds-4738	97	29	settings	setting	NOUN
ijpds-4738	97	30	window	window	NOUN
ijpds-4738	97	31	,	,	PUNCT
ijpds-4738	97	32	proper	proper	ADJ
ijpds-4738	97	33	method	method	NOUN
ijpds-4738	97	34	development	development	NOUN
ijpds-4738	97	35	entails	entail	VERB
ijpds-4738	97	36	improving	improve	VERB
ijpds-4738	97	37	and	and	CCONJ
ijpds-4738	97	38	refining	refine	VERB
ijpds-4738	97	39	these	these	DET
ijpds-4738	97	40	processes	process	NOUN
ijpds-4738	97	41	.	.	PUNCT
ijpds-4738	98	1	6	6	NUM
ijpds-4738	98	2	.	.	NOUN
ijpds-4738	98	3	routine	routine	ADJ
ijpds-4738	98	4	and	and	CCONJ
ijpds-4738	98	5	stability	stability	NOUN
ijpds-4738	98	6	testing	testing	NOUN
ijpds-4738	98	7	:	:	PUNCT
ijpds-4738	98	8	validation	validation	NOUN
ijpds-4738	98	9	parameters	parameter	NOUN
ijpds-4738	98	10	are	be	AUX
ijpds-4738	98	11	used	use	VERB
ijpds-4738	98	12	in	in	ADP
ijpds-4738	98	13	stability	stability	NOUN
ijpds-4738	98	14	testing	testing	NOUN
ijpds-4738	98	15	as	as	ADV
ijpds-4738	98	16	well	well	ADV
ijpds-4738	98	17	as	as	ADP
ijpds-4738	98	18	routine	routine	ADJ
ijpds-4738	98	19	analysis	analysis	NOUN
ijpds-4738	98	20	,	,	PUNCT
ijpds-4738	98	21	as	as	SCONJ
ijpds-4738	98	22	the	the	DET
ijpds-4738	98	23	latter	latter	ADJ
ijpds-4738	98	24	evaluates	evaluate	VERB
ijpds-4738	98	25	the	the	DET
ijpds-4738	98	26	stability	stability	NOUN
ijpds-4738	98	27	of	of	ADP
ijpds-4738	98	28	the	the	DET
ijpds-4738	98	29	final	final	ADJ
ijpds-4738	98	30	product	product	NOUN
ijpds-4738	98	31	and	and	CCONJ
ijpds-4738	98	32	the	the	DET
ijpds-4738	98	33	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	98	34	ingredient	ingredient	NOUN
ijpds-4738	98	35	that	that	PRON
ijpds-4738	98	36	is	be	AUX
ijpds-4738	98	37	active	active	ADJ
ijpds-4738	98	38	(	(	PUNCT
ijpds-4738	98	39	api	api	NOUN
ijpds-4738	98	40	)	)	PUNCT
ijpds-4738	98	41	over	over	ADP
ijpds-4738	98	42	time	time	NOUN
ijpds-4738	99	1	[	[	X
ijpds-4738	99	2	5,6,7	5,6,7	NOUN
ijpds-4738	99	3	]	]	X
ijpds-4738	99	4	.	.	PUNCT
ijpds-4738	100	1	method	method	PROPN
ijpds-4738	100	2	development	development	NOUN
ijpds-4738	100	3	the	the	DET
ijpds-4738	100	4	development	development	NOUN
ijpds-4738	100	5	and	and	CCONJ
ijpds-4738	100	6	validation	validation	NOUN
ijpds-4738	100	7	of	of	ADP
ijpds-4738	100	8	analytical	analytical	ADJ
ijpds-4738	100	9	methods	method	NOUN
ijpds-4738	100	10	are	be	AUX
ijpds-4738	100	11	crucial	crucial	ADJ
ijpds-4738	100	12	to	to	ADP
ijpds-4738	100	13	the	the	DET
ijpds-4738	100	14	process	process	NOUN
ijpds-4738	100	15	of	of	ADP
ijpds-4738	100	16	making	make	VERB
ijpds-4738	100	17	discoveries	discovery	NOUN
ijpds-4738	100	18	and	and	CCONJ
ijpds-4738	100	19	producing	produce	VERB
ijpds-4738	100	20	medications	medication	NOUN
ijpds-4738	100	21	.	.	PUNCT
ijpds-4738	101	1	these	these	DET
ijpds-4738	101	2	techniques	technique	NOUN
ijpds-4738	101	3	are	be	AUX
ijpds-4738	101	4	employed	employ	VERB
ijpds-4738	101	5	to	to	PART
ijpds-4738	101	6	guarantee	guarantee	VERB
ijpds-4738	101	7	drug	drug	NOUN
ijpds-4738	101	8	goods	good	NOUN
ijpds-4738	101	9	'	'	PART
ijpds-4738	101	10	authenticity	authenticity	NOUN
ijpds-4738	101	11	,	,	PUNCT
ijpds-4738	101	12	potency	potency	NOUN
ijpds-4738	101	13	,	,	PUNCT
ijpds-4738	101	14	purity	purity	NOUN
ijpds-4738	101	15	,	,	PUNCT
ijpds-4738	101	16	and	and	CCONJ
ijpds-4738	101	17	effectiveness	effectiveness	NOUN
ijpds-4738	101	18	.	.	PUNCT
ijpds-4738	102	1	when	when	SCONJ
ijpds-4738	102	2	creating	create	VERB
ijpds-4738	102	3	procedures	procedure	NOUN
ijpds-4738	102	4	,	,	PUNCT
ijpds-4738	102	5	there	there	PRON
ijpds-4738	102	6	are	be	VERB
ijpds-4738	102	7	several	several	ADJ
ijpds-4738	102	8	things	thing	NOUN
ijpds-4738	102	9	to	to	PART
ijpds-4738	102	10	take	take	VERB
ijpds-4738	102	11	into	into	ADP
ijpds-4738	102	12	account	account	NOUN
ijpds-4738	102	13	.	.	PUNCT
ijpds-4738	103	1	initially	initially	ADV
ijpds-4738	103	2	,	,	PUNCT
ijpds-4738	103	3	data	datum	NOUN
ijpds-4738	103	4	on	on	ADP
ijpds-4738	103	5	the	the	DET
ijpds-4738	103	6	analyte	analyte	NOUN
ijpds-4738	103	7	's	's	PART
ijpds-4738	103	8	physiochemical	physiochemical	ADJ
ijpds-4738	103	9	properties	property	NOUN
ijpds-4738	103	10	(	(	PUNCT
ijpds-4738	103	11	pka	pka	NOUN
ijpds-4738	103	12	,	,	PUNCT
ijpds-4738	103	13	log	log	VERB
ijpds-4738	103	14	p	p	NOUN
ijpds-4738	103	15	,	,	PUNCT
ijpds-4738	103	16	and	and	CCONJ
ijpds-4738	103	17	solubility	solubility	NOUN
ijpds-4738	103	18	)	)	PUNCT
ijpds-4738	103	19	are	be	AUX
ijpds-4738	103	20	recorded	record	VERB
ijpds-4738	103	21	,	,	PUNCT
ijpds-4738	103	22	and	and	CCONJ
ijpds-4738	103	23	if	if	SCONJ
ijpds-4738	103	24	uv	uv	NOUN
ijpds-4738	103	25	detection	detection	NOUN
ijpds-4738	103	26	is	be	AUX
ijpds-4738	103	27	required	require	VERB
ijpds-4738	103	28	,	,	PUNCT
ijpds-4738	103	29	the	the	DET
ijpds-4738	103	30	suitable	suitable	ADJ
ijpds-4738	103	31	detection	detection	NOUN
ijpds-4738	103	32	mode	mode	NOUN
ijpds-4738	103	33	is	be	AUX
ijpds-4738	103	34	chosen	choose	VERB
ijpds-4738	103	35	,	,	PUNCT
ijpds-4738	103	36	and	and	CCONJ
ijpds-4738	103	37	if	if	SCONJ
ijpds-4738	103	38	uv	uv	NOUN
ijpds-4738	103	39	detection	detection	NOUN
ijpds-4738	103	40	is	be	AUX
ijpds-4738	103	41	needed	need	VERB
ijpds-4738	103	42	,	,	PUNCT
ijpds-4738	103	43	the	the	DET
ijpds-4738	103	44	appropriate	appropriate	ADJ
ijpds-4738	103	45	mode	mode	NOUN
ijpds-4738	103	46	of	of	ADP
ijpds-4738	103	47	detection	detection	NOUN
ijpds-4738	103	48	is	be	AUX
ijpds-4738	103	49	determined	determine	VERB
ijpds-4738	103	50	.	.	PUNCT
ijpds-4738	104	1	the	the	DET
ijpds-4738	104	2	validation	validation	NOUN
ijpds-4738	104	3	of	of	ADP
ijpds-4738	104	4	a	a	DET
ijpds-4738	104	5	stabilityindicating	stabilityindicating	NOUN
ijpds-4738	104	6	hplc	hplc	NOUN
ijpds-4738	104	7	method	method	NOUN
ijpds-4738	104	8	constitutes	constitute	VERB
ijpds-4738	104	9	the	the	DET
ijpds-4738	104	10	principal	principal	ADJ
ijpds-4738	104	11	focus	focus	NOUN
ijpds-4738	104	12	of	of	ADP
ijpds-4738	104	13	analytical	analytical	ADJ
ijpds-4738	104	14	development	development	NOUN
ijpds-4738	104	15	efforts	effort	NOUN
ijpds-4738	104	16	.	.	PUNCT
ijpds-4738	105	1	trying	try	VERB
ijpds-4738	105	2	to	to	PART
ijpds-4738	105	3	isolate	isolate	VERB
ijpds-4738	105	4	and	and	CCONJ
ijpds-4738	105	5	quantify	quantify	VERB
ijpds-4738	105	6	the	the	DET
ijpds-4738	105	7	primary	primary	ADJ
ijpds-4738	105	8	active	active	ADJ
ijpds-4738	105	9	ingredient	ingredient	NOUN
ijpds-4738	105	10	,	,	PUNCT
ijpds-4738	105	11	any	any	DET
ijpds-4738	105	12	reaction	reaction	NOUN
ijpds-4738	105	13	impurities	impurity	NOUN
ijpds-4738	105	14	,	,	PUNCT
ijpds-4738	105	15	any	any	DET
ijpds-4738	105	16	synthetic	synthetic	ADJ
ijpds-4738	105	17	intermediates	intermediate	NOUN
ijpds-4738	105	18	that	that	PRON
ijpds-4738	105	19	are	be	AUX
ijpds-4738	105	20	accessible	accessible	ADJ
ijpds-4738	105	21	,	,	PUNCT
ijpds-4738	105	22	and	and	CCONJ
ijpds-4738	105	23	any	any	DET
ijpds-4738	105	24	degradants	degradant	NOUN
ijpds-4738	105	25	are	be	AUX
ijpds-4738	105	26	the	the	DET
ijpds-4738	105	27	objectives	objective	NOUN
ijpds-4738	105	28	of	of	ADP
ijpds-4738	105	29	the	the	DET
ijpds-4738	105	30	hplc	hplc	NOUN
ijpds-4738	105	31	-	-	PUNCT
ijpds-4738	105	32	method	method	NOUN
ijpds-4738	105	33	[	[	X
ijpds-4738	105	34	8	8	NUM
ijpds-4738	105	35	,	,	PUNCT
ijpds-4738	105	36	9	9	NUM
ijpds-4738	105	37	]	]	PUNCT
ijpds-4738	105	38	.	.	PUNCT
ijpds-4738	106	1	criteria	criterion	NOUN
ijpds-4738	106	2	for	for	ADP
ijpds-4738	106	3	the	the	DET
ijpds-4738	106	4	development	development	NOUN
ijpds-4738	106	5	of	of	ADP
ijpds-4738	106	6	new	new	ADJ
ijpds-4738	106	7	analytical	analytical	ADJ
ijpds-4738	106	8	method	method	NOUN
ijpds-4738	106	9	:	:	PUNCT
ijpds-4738	106	10	the	the	DET
ijpds-4738	106	11	identification	identification	NOUN
ijpds-4738	106	12	of	of	ADP
ijpds-4738	106	13	the	the	DET
ijpds-4738	106	14	product	product	NOUN
ijpds-4738	106	15	is	be	AUX
ijpds-4738	106	16	predicated	predicate	VERB
ijpds-4738	106	17	on	on	ADP
ijpds-4738	106	18	the	the	DET
ijpds-4738	106	19	evaluation	evaluation	NOUN
ijpds-4738	106	20	procedure	procedure	NOUN
ijpds-4738	106	21	of	of	ADP
ijpds-4738	106	22	pharmaceuticals	pharmaceutical	NOUN
ijpds-4738	106	23	.	.	PUNCT
ijpds-4738	107	1	the	the	DET
ijpds-4738	107	2	addition	addition	NOUN
ijpds-4738	107	3	of	of	ADP
ijpds-4738	107	4	a	a	DET
ijpds-4738	107	5	medicine	medicine	NOUN
ijpds-4738	107	6	to	to	ADP
ijpds-4738	107	7	pharmacopoeias	pharmacopoeia	NOUN
ijpds-4738	107	8	and	and	CCONJ
ijpds-4738	107	9	its	its	PRON
ijpds-4738	107	10	commercial	commercial	ADJ
ijpds-4738	107	11	release	release	NOUN
ijpds-4738	107	12	date	date	NOUN
ijpds-4738	107	13	frequently	frequently	ADV
ijpds-4738	107	14	fall	fall	VERB
ijpds-4738	107	15	on	on	ADP
ijpds-4738	107	16	the	the	DET
ijpds-4738	107	17	same	same	ADJ
ijpds-4738	107	18	day	day	NOUN
ijpds-4738	107	19	.	.	PUNCT
ijpds-4738	108	1	this	this	PRON
ijpds-4738	108	2	is	be	AUX
ijpds-4738	108	3	brought	bring	VERB
ijpds-4738	108	4	on	on	ADP
ijpds-4738	108	5	by	by	ADP
ijpds-4738	108	6	new	new	ADJ
ijpds-4738	108	7	toxicity	toxicity	NOUN
ijpds-4738	108	8	reports	report	NOUN
ijpds-4738	108	9	,	,	PUNCT
ijpds-4738	108	10	patient	patient	ADJ
ijpds-4738	108	11	resistance	resistance	NOUN
ijpds-4738	108	12	developing	develop	VERB
ijpds-4738	108	13	over	over	ADP
ijpds-4738	108	14	time	time	NOUN
ijpds-4738	108	15	,	,	PUNCT
ijpds-4738	108	16	potential	potential	ADJ
ijpds-4738	108	17	concerns	concern	NOUN
ijpds-4738	108	18	about	about	ADP
ijpds-4738	108	19	the	the	DET
ijpds-4738	108	20	prolonged	prolonged	ADJ
ijpds-4738	108	21	and	and	CCONJ
ijpds-4738	108	22	increased	increase	VERB
ijpds-4738	108	23	use	use	NOUN
ijpds-4738	108	24	of	of	ADP
ijpds-4738	108	25	these	these	DET
ijpds-4738	108	26	medicines	medicine	NOUN
ijpds-4738	108	27	,	,	PUNCT
ijpds-4738	108	28	and	and	CCONJ
ijpds-4738	108	29	the	the	DET
ijpds-4738	108	30	launch	launch	NOUN
ijpds-4738	108	31	of	of	ADP
ijpds-4738	108	32	more	more	ADV
ijpds-4738	108	33	potent	potent	ADJ
ijpds-4738	108	34	drugs	drug	NOUN
ijpds-4738	108	35	by	by	ADP
ijpds-4738	108	36	rival	rival	ADJ
ijpds-4738	108	37	companies	company	NOUN
ijpds-4738	108	38	.	.	PUNCT
ijpds-4738	109	1	the	the	DET
ijpds-4738	109	2	novel	novel	ADJ
ijpds-4738	109	3	medication	medication	NOUN
ijpds-4738	109	4	or	or	CCONJ
ijpds-4738	109	5	combination	combination	NOUN
ijpds-4738	109	6	of	of	ADP
ijpds-4738	109	7	medications	medication	NOUN
ijpds-4738	109	8	might	might	AUX
ijpds-4738	109	9	not	not	PART
ijpds-4738	109	10	be	be	AUX
ijpds-4738	109	11	classified	classify	VERB
ijpds-4738	109	12	in	in	ADP
ijpds-4738	109	13	any	any	DET
ijpds-4738	109	14	pharmacopoeia	pharmacopoeia	NOUN
ijpds-4738	109	15	.	.	PUNCT
ijpds-4738	110	1	it	it	PRON
ijpds-4738	110	2	's	be	AUX
ijpds-4738	110	3	possible	possible	ADJ
ijpds-4738	110	4	that	that	SCONJ
ijpds-4738	110	5	analytical	analytical	ADJ
ijpds-4738	110	6	methods	method	NOUN
ijpds-4738	110	7	for	for	ADP
ijpds-4738	110	8	quantifying	quantify	VERB
ijpds-4738	110	9	the	the	DET
ijpds-4738	110	10	drug	drug	NOUN
ijpds-4738	110	11	in	in	ADP
ijpds-4738	110	12	body	body	NOUN
ijpds-4738	110	13	fluids	fluid	NOUN
ijpds-4738	110	14	are	be	AUX
ijpds-4738	110	15	unavailable	unavailable	ADJ
ijpds-4738	110	16	.	.	PUNCT
ijpds-4738	111	1	the	the	DET
ijpds-4738	111	2	present	present	ADJ
ijpds-4738	111	3	tests	test	NOUN
ijpds-4738	111	4	may	may	AUX
ijpds-4738	111	5	require	require	VERB
ijpds-4738	111	6	the	the	DET
ijpds-4738	111	7	use	use	NOUN
ijpds-4738	111	8	of	of	ADP
ijpds-4738	111	9	pricey	pricey	ADJ
ijpds-4738	111	10	materials	material	NOUN
ijpds-4738	111	11	and	and	CCONJ
ijpds-4738	111	12	chemicals	chemical	NOUN
ijpds-4738	111	13	.	.	PUNCT
ijpds-4738	112	1	it	it	PRON
ijpds-4738	112	2	may	may	AUX
ijpds-4738	112	3	also	also	ADV
ijpds-4738	112	4	need	need	VERB
ijpds-4738	112	5	timeconsuming	timeconsuming	ADJ
ijpds-4738	112	6	and	and	CCONJ
ijpds-4738	112	7	sometimes	sometimes	ADV
ijpds-4738	112	8	unreliable	unreliable	ADJ
ijpds-4738	112	9	extraction	extraction	NOUN
ijpds-4738	112	10	and	and	CCONJ
ijpds-4738	112	11	separation	separation	NOUN
ijpds-4738	112	12	processes	process	NOUN
ijpds-4738	112	13	[	[	X
ijpds-4738	112	14	10	10	NUM
ijpds-4738	112	15	,	,	PUNCT
ijpds-4738	112	16	11	11	NUM
ijpds-4738	112	17	]	]	PUNCT
ijpds-4738	112	18	.	.	PUNCT
ijpds-4738	113	1			NOUN
ijpds-4738	113	2	hplc	hplc	PROPN
ijpds-4738	113	3	method	method	PROPN
ijpds-4738	113	4	development	development	NOUN
ijpds-4738	113	5	1	1	NUM
ijpds-4738	113	6	.	.	PUNCT
ijpds-4738	114	1	recognizing	recognize	VERB
ijpds-4738	114	2	the	the	DET
ijpds-4738	114	3	drug	drug	NOUN
ijpds-4738	114	4	molecule	molecule	NOUN
ijpds-4738	114	5	's	's	PART
ijpds-4738	114	6	physicochemical	physicochemical	ADJ
ijpds-4738	114	7	characteristics	characteristic	NOUN
ijpds-4738	114	8	.	.	PUNCT
ijpds-4738	115	1	when	when	SCONJ
ijpds-4738	115	2	developing	develop	VERB
ijpds-4738	115	3	a	a	DET
ijpds-4738	115	4	technique	technique	NOUN
ijpds-4738	115	5	,	,	PUNCT
ijpds-4738	115	6	a	a	DET
ijpds-4738	115	7	medicinal	medicinal	ADJ
ijpds-4738	115	8	molecule	molecule	NOUN
ijpds-4738	115	9	's	's	PART
ijpds-4738	115	10	physicochemical	physicochemical	ADJ
ijpds-4738	115	11	characteristics	characteristic	NOUN
ijpds-4738	115	12	are	be	AUX
ijpds-4738	115	13	crucial	crucial	ADJ
ijpds-4738	115	14	.	.	PUNCT
ijpds-4738	116	1	the	the	DET
ijpds-4738	116	2	physical	physical	ADJ
ijpds-4738	116	3	characteristics	characteristic	NOUN
ijpds-4738	116	4	of	of	ADP
ijpds-4738	116	5	the	the	DET
ijpds-4738	116	6	drug	drug	NOUN
ijpds-4738	116	7	molecule	molecule	NOUN
ijpds-4738	116	8	,	,	PUNCT
ijpds-4738	116	9	such	such	ADJ
ijpds-4738	116	10	as	as	ADP
ijpds-4738	116	11	its	its	PRON
ijpds-4738	116	12	ph	ph	NOUN
ijpds-4738	116	13	,	,	PUNCT
ijpds-4738	116	14	polarity	polarity	NOUN
ijpds-4738	116	15	,	,	PUNCT
ijpds-4738	116	16	solubility	solubility	NOUN
ijpds-4738	116	17	,	,	PUNCT
ijpds-4738	116	18	and	and	CCONJ
ijpds-4738	116	19	pka	pka	NOUN
ijpds-4738	116	20	,	,	PUNCT
ijpds-4738	116	21	must	must	AUX
ijpds-4738	116	22	be	be	AUX
ijpds-4738	116	23	studied	study	VERB
ijpds-4738	116	24	in	in	ADP
ijpds-4738	116	25	order	order	NOUN
ijpds-4738	116	26	to	to	PART
ijpds-4738	116	27	build	build	VERB
ijpds-4738	116	28	a	a	DET
ijpds-4738	116	29	method	method	NOUN
ijpds-4738	116	30	.	.	PUNCT
ijpds-4738	117	1	one	one	NUM
ijpds-4738	117	2	of	of	ADP
ijpds-4738	117	3	a	a	DET
ijpds-4738	117	4	compound	compound	NOUN
ijpds-4738	117	5	's	's	PART
ijpds-4738	117	6	physical	physical	ADJ
ijpds-4738	117	7	characteristics	characteristic	NOUN
ijpds-4738	117	8	is	be	AUX
ijpds-4738	117	9	polarity	polarity	NOUN
ijpds-4738	117	10	.	.	PUNCT
ijpds-4738	118	1	it	it	PRON
ijpds-4738	118	2	aids	aid	VERB
ijpds-4738	118	3	in	in	ADP
ijpds-4738	118	4	the	the	DET
ijpds-4738	118	5	determination	determination	NOUN
ijpds-4738	118	6	of	of	ADP
ijpds-4738	118	7	the	the	DET
ijpds-4738	118	8	mobile	mobile	ADJ
ijpds-4738	118	9	phase	phase	NOUN
ijpds-4738	118	10	's	's	PART
ijpds-4738	118	11	solvent	solvent	NOUN
ijpds-4738	118	12	and	and	CCONJ
ijpds-4738	118	13	composition	composition	NOUN
ijpds-4738	118	14	by	by	ADP
ijpds-4738	118	15	the	the	DET
ijpds-4738	118	16	analyzer	analyzer	NOUN
ijpds-4738	118	17	.	.	PUNCT
ijpds-4738	119	1	the	the	DET
ijpds-4738	119	2	polarity	polarity	NOUN
ijpds-4738	119	3	of	of	ADP
ijpds-4738	119	4	molecules	molecule	NOUN
ijpds-4738	119	5	that	that	PRON
ijpds-4738	119	6	are	be	AUX
ijpds-4738	119	7	provides	provide	VERB
ijpds-4738	119	8	an	an	DET
ijpds-4738	119	9	explanation	explanation	NOUN
ijpds-4738	119	10	for	for	ADP
ijpds-4738	119	11	their	their	PRON
ijpds-4738	119	12	solubility	solubility	NOUN
ijpds-4738	119	13	.	.	PUNCT
ijpds-4738	120	1	solvents	solvent	NOUN
ijpds-4738	120	2	that	that	PRON
ijpds-4738	120	3	are	be	AUX
ijpds-4738	120	4	polar	polar	ADJ
ijpds-4738	120	5	,	,	PUNCT
ijpds-4738	120	6	like	like	ADP
ijpds-4738	120	7	water	water	NOUN
ijpds-4738	120	8	,	,	PUNCT
ijpds-4738	120	9	and	and	CCONJ
ijpds-4738	120	10	nonpolar	nonpolar	ADJ
ijpds-4738	120	11	,	,	PUNCT
ijpds-4738	120	12	like	like	ADP
ijpds-4738	120	13	benzene	benzene	NOUN
ijpds-4738	120	14	,	,	PUNCT
ijpds-4738	120	15	do	do	AUX
ijpds-4738	120	16	not	not	PART
ijpds-4738	120	17	combine	combine	VERB
ijpds-4738	120	18	.	.	PUNCT
ijpds-4738	121	1	ph	ph	PROPN
ijpds-4738	121	2	is	be	AUX
ijpds-4738	121	3	characterized	characterize	VERB
ijpds-4738	121	4	as	as	ADP
ijpds-4738	121	5	the	the	DET
ijpds-4738	121	6	negative	negative	ADJ
ijpds-4738	121	7	logarithm	logarithm	NOUN
ijpds-4738	121	8	patil	patil	PROPN
ijpds-4738	121	9	et	et	PROPN
ijpds-4738	121	10	al	al	PROPN
ijpds-4738	121	11	.	.	PROPN
ijpds-4738	122	1	analytical	analytical	ADJ
ijpds-4738	122	2	method	method	PROPN
ijpds-4738	122	3	development	development	NOUN
ijpds-4738	122	4	and	and	CCONJ
ijpds-4738	122	5	validation	validation	NOUN
ijpds-4738	122	6	online	online	ADJ
ijpds-4738	122	7	first	first	PROPN
ijpds-4738	122	8	indian	indian	PROPN
ijpds-4738	122	9	j	j	PROPN
ijpds-4738	122	10	pharm	pharm	PROPN
ijpds-4738	122	11	drug	drug	PROPN
ijpds-4738	122	12	studies	study	NOUN
ijpds-4738	122	13	|	|	ADV
ijpds-4738	122	14	3	3	NUM
ijpds-4738	122	15	of	of	ADP
ijpds-4738	122	16	the	the	DET
ijpds-4738	122	17	h+	h+	X
ijpds-4738	122	18	ion	ion	NOUN
ijpds-4738	122	19	concentration	concentration	NOUN
ijpds-4738	122	20	to	to	PART
ijpds-4738	122	21	base	base	VERB
ijpds-4738	122	22	10	10	NUM
ijpds-4738	122	23	.	.	PUNCT
ijpds-4738	123	1	the	the	DET
ijpds-4738	123	2	ph	ph	ADJ
ijpds-4738	123	3	scale	scale	NOUN
ijpds-4738	123	4	is	be	AUX
ijpds-4738	123	5	log10[h3o+	log10[h3o+	NOUN
ijpds-4738	123	6	]	]	X
ijpds-4738	123	7	.	.	PUNCT
ijpds-4738	124	1	sharp	sharp	ADJ
ijpds-4738	124	2	,	,	PUNCT
ijpds-4738	124	3	symmetrical	symmetrical	ADJ
ijpds-4738	124	4	peaks	peak	NOUN
ijpds-4738	124	5	are	be	AUX
ijpds-4738	124	6	consistently	consistently	ADV
ijpds-4738	124	7	observed	observe	VERB
ijpds-4738	124	8	in	in	ADP
ijpds-4738	124	9	hplc	hplc	NOUN
ijpds-4738	124	10	when	when	SCONJ
ijpds-4738	124	11	ionizable	ionizable	ADJ
ijpds-4738	124	12	analytes	analyte	NOUN
ijpds-4738	124	13	are	be	AUX
ijpds-4738	124	14	selected	select	VERB
ijpds-4738	124	15	at	at	ADP
ijpds-4738	124	16	the	the	DET
ijpds-4738	124	17	proper	proper	ADJ
ijpds-4738	124	18	ph	ph	ADJ
ijpds-4738	124	19	.	.	PROPN
ijpds-4738	124	20	quantitative	quantitative	ADJ
ijpds-4738	124	21	analysis	analysis	NOUN
ijpds-4738	124	22	requires	require	VERB
ijpds-4738	124	23	sharply	sharply	ADV
ijpds-4738	124	24	symmetrical	symmetrical	ADJ
ijpds-4738	124	25	heights	height	NOUN
ijpds-4738	124	26	in	in	ADP
ijpds-4738	124	27	order	order	NOUN
ijpds-4738	124	28	to	to	PART
ijpds-4738	124	29	ensure	ensure	VERB
ijpds-4738	124	30	low	low	ADJ
ijpds-4738	124	31	relative	relative	ADJ
ijpds-4738	124	32	standard	standard	ADJ
ijpds-4738	124	33	deviations	deviation	NOUN
ijpds-4738	124	34	between	between	ADP
ijpds-4738	124	35	injections	injection	NOUN
ijpds-4738	124	36	,	,	PUNCT
ijpds-4738	124	37	minimal	minimal	ADJ
ijpds-4738	124	38	detection	detection	NOUN
ijpds-4738	124	39	limits	limit	NOUN
ijpds-4738	124	40	,	,	PUNCT
ijpds-4738	124	41	and	and	CCONJ
ijpds-4738	124	42	predictable	predictable	ADJ
ijpds-4738	124	43	retention	retention	NOUN
ijpds-4738	124	44	durations	duration	NOUN
ijpds-4738	125	1	[	[	X
ijpds-4738	125	2	12	12	NUM
ijpds-4738	125	3	,	,	PUNCT
ijpds-4738	125	4	13	13	NUM
ijpds-4738	125	5	]	]	PUNCT
ijpds-4738	125	6	.	.	PUNCT
ijpds-4738	126	1	2	2	X
ijpds-4738	126	2	.	.	X
ijpds-4738	126	3	the	the	DET
ijpds-4738	126	4	chromatographic	chromatographic	ADJ
ijpds-4738	126	5	conditions	condition	NOUN
ijpds-4738	126	6	chosen	choose	VERB
ijpds-4738	126	7	:	:	PUNCT
ijpds-4738	126	8	selection	selection	NOUN
ijpds-4738	126	9	of	of	ADP
ijpds-4738	126	10	column	column	NOUN
ijpds-4738	126	11	:	:	PUNCT
ijpds-4738	126	12	in	in	ADP
ijpds-4738	126	13	method	method	NOUN
ijpds-4738	126	14	development	development	NOUN
ijpds-4738	126	15	,	,	PUNCT
ijpds-4738	126	16	choosing	choose	VERB
ijpds-4738	126	17	the	the	DET
ijpds-4738	126	18	stationary	stationary	ADJ
ijpds-4738	126	19	phase	phase	NOUN
ijpds-4738	126	20	or	or	CCONJ
ijpds-4738	126	21	column	column	NOUN
ijpds-4738	126	22	is	be	AUX
ijpds-4738	126	23	the	the	DET
ijpds-4738	126	24	first	first	ADJ
ijpds-4738	126	25	and	and	CCONJ
ijpds-4738	126	26	most	most	ADV
ijpds-4738	126	27	crucial	crucial	ADJ
ijpds-4738	126	28	step	step	NOUN
ijpds-4738	126	29	.	.	PUNCT
ijpds-4738	127	1	without	without	ADP
ijpds-4738	127	2	a	a	DET
ijpds-4738	127	3	reliable	reliable	ADJ
ijpds-4738	127	4	,	,	PUNCT
ijpds-4738	127	5	high	high	ADV
ijpds-4738	127	6	-	-	PUNCT
ijpds-4738	127	7	performing	perform	VERB
ijpds-4738	127	8	column	column	NOUN
ijpds-4738	127	9	,	,	PUNCT
ijpds-4738	127	10	it	it	PRON
ijpds-4738	127	11	is	be	AUX
ijpds-4738	127	12	difficult	difficult	ADJ
ijpds-4738	127	13	to	to	PART
ijpds-4738	127	14	design	design	VERB
ijpds-4738	127	15	a	a	DET
ijpds-4738	127	16	robust	robust	ADJ
ijpds-4738	127	17	and	and	CCONJ
ijpds-4738	127	18	repeatable	repeatable	ADJ
ijpds-4738	127	19	procedure	procedure	NOUN
ijpds-4738	127	20	.	.	PUNCT
ijpds-4738	128	1	stable	stable	ADJ
ijpds-4738	128	2	and	and	CCONJ
ijpds-4738	128	3	repeatable	repeatable	ADJ
ijpds-4738	128	4	columns	column	NOUN
ijpds-4738	128	5	are	be	AUX
ijpds-4738	128	6	crucial	crucial	ADJ
ijpds-4738	128	7	to	to	PART
ijpds-4738	128	8	prevent	prevent	VERB
ijpds-4738	128	9	issues	issue	NOUN
ijpds-4738	128	10	with	with	ADP
ijpds-4738	128	11	irreproducible	irreproducible	ADJ
ijpds-4738	128	12	sample	sample	NOUN
ijpds-4738	128	13	retention	retention	NOUN
ijpds-4738	128	14	through	through	ADP
ijpds-4738	128	15	method	method	NOUN
ijpds-4738	128	16	development	development	NOUN
ijpds-4738	128	17	.	.	PUNCT
ijpds-4738	129	1	all	all	DET
ijpds-4738	129	2	samples	sample	NOUN
ijpds-4738	129	3	may	may	AUX
ijpds-4738	129	4	normally	normally	ADV
ijpds-4738	129	5	be	be	AUX
ijpds-4738	129	6	separated	separate	VERB
ijpds-4738	129	7	using	use	VERB
ijpds-4738	129	8	a	a	DET
ijpds-4738	129	9	c8	c8	NOUN
ijpds-4738	129	10	or	or	CCONJ
ijpds-4738	129	11	c18	c18	NOUN
ijpds-4738	129	12	column	column	NOUN
ijpds-4738	129	13	,	,	PUNCT
ijpds-4738	129	14	which	which	PRON
ijpds-4738	129	15	is	be	AUX
ijpds-4738	129	16	highly	highly	ADV
ijpds-4738	129	17	recommended	recommend	VERB
ijpds-4738	129	18	.	.	PUNCT
ijpds-4738	130	1	these	these	DET
ijpds-4738	130	2	columns	column	NOUN
ijpds-4738	130	3	are	be	AUX
ijpds-4738	130	4	built	build	VERB
ijpds-4738	130	5	from	from	ADP
ijpds-4738	130	6	carefully	carefully	ADV
ijpds-4738	130	7	purified	purify	VERB
ijpds-4738	130	8	,	,	PUNCT
ijpds-4738	130	9	lower	low	ADJ
ijpds-4738	130	10	-	-	PUNCT
ijpds-4738	130	11	acid	acid	NOUN
ijpds-4738	130	12	silica	silica	NOUN
ijpds-4738	130	13	as	as	ADV
ijpds-4738	130	14	well	well	ADV
ijpds-4738	130	15	as	as	ADP
ijpds-4738	130	16	being	be	AUX
ijpds-4738	130	17	particularly	particularly	ADV
ijpds-4738	130	18	developed	develop	VERB
ijpds-4738	130	19	for	for	ADP
ijpds-4738	130	20	the	the	DET
ijpds-4738	130	21	separation	separation	NOUN
ijpds-4738	130	22	from	from	ADP
ijpds-4738	130	23	basic	basic	ADJ
ijpds-4738	130	24	chemicals	chemical	NOUN
ijpds-4738	130	25	[	[	X
ijpds-4738	130	26	14	14	NUM
ijpds-4738	130	27	]	]	PUNCT
ijpds-4738	130	28	.	.	PUNCT
ijpds-4738	131	1	the	the	DET
ijpds-4738	131	2	primary	primary	ADJ
ijpds-4738	131	3	ones	one	NOUN
ijpds-4738	131	4	are	be	AUX
ijpds-4738	131	5	the	the	DET
ijpds-4738	131	6	column	column	NOUN
ijpds-4738	131	7	diameters	diameter	NOUN
ijpds-4738	131	8	,	,	PUNCT
ijpds-4738	131	9	the	the	DET
ijpds-4738	131	10	silica	silica	NOUN
ijpds-4738	131	11	substrate	substrate	NOUN
ijpds-4738	131	12	qualities	quality	NOUN
ijpds-4738	131	13	,	,	PUNCT
ijpds-4738	131	14	and	and	CCONJ
ijpds-4738	131	15	the	the	DET
ijpds-4738	131	16	bonded	bond	VERB
ijpds-4738	131	17	stationary	stationary	ADJ
ijpds-4738	131	18	phase	phase	NOUN
ijpds-4738	131	19	features	feature	VERB
ijpds-4738	131	20	.	.	PUNCT
ijpds-4738	132	1	for	for	ADP
ijpds-4738	132	2	a	a	DET
ijpds-4738	132	3	number	number	NOUN
ijpds-4738	132	4	of	of	ADP
ijpds-4738	132	5	physical	physical	ADJ
ijpds-4738	132	6	reasons	reason	NOUN
ijpds-4738	132	7	,	,	PUNCT
ijpds-4738	132	8	silica	silica	NOUN
ijpds-4738	132	9	-	-	PUNCT
ijpds-4738	132	10	based	base	VERB
ijpds-4738	132	11	packing	packing	NOUN
ijpds-4738	132	12	is	be	AUX
ijpds-4738	132	13	preferred	prefer	VERB
ijpds-4738	132	14	in	in	ADP
ijpds-4738	132	15	the	the	DET
ijpds-4738	132	16	majority	majority	NOUN
ijpds-4738	132	17	of	of	ADP
ijpds-4738	132	18	current	current	ADJ
ijpds-4738	132	19	hplc	hplc	NOUN
ijpds-4738	132	20	column	column	NOUN
ijpds-4738	132	21	[	[	X
ijpds-4738	132	22	15	15	NUM
ijpds-4738	132	23	]	]	PUNCT
ijpds-4738	132	24	.	.	PUNCT
ijpds-4738	133	1	3	3	X
ijpds-4738	133	2	.	.	X
ijpds-4738	133	3	improving	improve	VERB
ijpds-4738	133	4	the	the	DET
ijpds-4738	133	5	mobile	mobile	ADJ
ijpds-4738	133	6	stage	stage	NOUN
ijpds-4738	133	7	a	a	DET
ijpds-4738	133	8	)	)	PUNCT
ijpds-4738	133	9	buffer	buffer	NOUN
ijpds-4738	133	10	selection	selection	NOUN
ijpds-4738	133	11	:	:	PUNCT
ijpds-4738	133	12	the	the	DET
ijpds-4738	133	13	intended	intended	ADJ
ijpds-4738	133	14	ph	ph	ADJ
ijpds-4738	133	15	determines	determine	NOUN
ijpds-4738	133	16	which	which	PRON
ijpds-4738	133	17	buffer	buffer	VERB
ijpds-4738	133	18	to	to	AUX
ijpds-4738	133	19	use	use	VERB
ijpds-4738	133	20	.	.	PUNCT
ijpds-4738	134	1	when	when	SCONJ
ijpds-4738	134	2	reversed	reverse	VERB
ijpds-4738	134	3	phase	phase	NOUN
ijpds-4738	134	4	on	on	ADP
ijpds-4738	134	5	silica	silica	NOUN
ijpds-4738	134	6	-	-	PUNCT
ijpds-4738	134	7	based	base	VERB
ijpds-4738	134	8	packaging	packaging	NOUN
ijpds-4738	134	9	,	,	PUNCT
ijpds-4738	134	10	the	the	DET
ijpds-4738	134	11	usual	usual	ADJ
ijpds-4738	134	12	ph	ph	ADJ
ijpds-4738	134	13	range	range	NOUN
ijpds-4738	134	14	is	be	AUX
ijpds-4738	134	15	2	2	NUM
ijpds-4738	134	16	to	to	PART
ijpds-4738	134	17	8	8	NUM
ijpds-4738	134	18	.	.	PUNCT
ijpds-4738	135	1	since	since	SCONJ
ijpds-4738	135	2	buffers	buffer	NOUN
ijpds-4738	135	3	regulate	regulate	VERB
ijpds-4738	135	4	ph	ph	ADV
ijpds-4738	135	5	best	good	ADJ
ijpds-4738	135	6	at	at	ADP
ijpds-4738	135	7	their	their	PRON
ijpds-4738	135	8	pka	pka	NOUN
ijpds-4738	135	9	,	,	PUNCT
ijpds-4738	135	10	it	it	PRON
ijpds-4738	135	11	is	be	AUX
ijpds-4738	135	12	critical	critical	ADJ
ijpds-4738	135	13	that	that	SCONJ
ijpds-4738	135	14	the	the	DET
ijpds-4738	135	15	buffer	buffer	NOUN
ijpds-4738	135	16	's	's	PART
ijpds-4738	135	17	pka	pka	NOUN
ijpds-4738	135	18	be	be	AUX
ijpds-4738	135	19	somewhat	somewhat	ADV
ijpds-4738	135	20	near	near	ADP
ijpds-4738	135	21	the	the	DET
ijpds-4738	135	22	intended	intend	VERB
ijpds-4738	135	23	ph	ph	VERB
ijpds-4738	135	24	.	.	PROPN
ijpds-4738	135	25	generally	generally	ADV
ijpds-4738	135	26	speaking	speak	VERB
ijpds-4738	135	27	,	,	PUNCT
ijpds-4738	135	28	pick	pick	VERB
ijpds-4738	135	29	a	a	DET
ijpds-4738	135	30	buffer	buffer	NOUN
ijpds-4738	135	31	with	with	ADP
ijpds-4738	135	32	a	a	DET
ijpds-4738	135	33	pka	pka	NOUN
ijpds-4738	135	34	value	value	NOUN
ijpds-4738	135	35	.	.	PUNCT
ijpds-4738	136	1	general	general	ADJ
ijpds-4738	136	2	consideration	consideration	NOUN
ijpds-4738	136	3	for	for	ADP
ijpds-4738	136	4	buffer	buffer	NOUN
ijpds-4738	136	5	selection	selection	NOUN
ijpds-4738	136	6	:	:	PUNCT
ijpds-4738	136	7	a.	a.	NOUN
ijpds-4738	136	8	phosphate	phosphate	NOUN
ijpds-4738	136	9	seems	seem	VERB
ijpds-4738	136	10	to	to	PART
ijpds-4738	136	11	be	be	AUX
ijpds-4738	136	12	more	more	ADV
ijpds-4738	136	13	soluble	soluble	ADJ
ijpds-4738	136	14	in	in	ADP
ijpds-4738	136	15	methanol	methanol	NOUN
ijpds-4738	136	16	/	/	SYM
ijpds-4738	136	17	water	water	NOUN
ijpds-4738	136	18	than	than	ADP
ijpds-4738	136	19	in	in	ADP
ijpds-4738	136	20	acetonitrile	acetonitrile	NOUN
ijpds-4738	136	21	or	or	CCONJ
ijpds-4738	136	22	thf	thf	NOUN
ijpds-4738	136	23	/	/	SYM
ijpds-4738	136	24	water	water	NOUN
ijpds-4738	136	25	.	.	PUNCT
ijpds-4738	137	1	b.	b.	PROPN
ijpds-4738	138	1	due	due	ADP
ijpds-4738	138	2	to	to	ADP
ijpds-4738	138	3	their	their	PRON
ijpds-4738	138	4	significant	significant	ADJ
ijpds-4738	138	5	hygroscopicity	hygroscopicity	NOUN
ijpds-4738	138	6	,	,	PUNCT
ijpds-4738	138	7	some	some	DET
ijpds-4738	138	8	salt	salt	NOUN
ijpds-4738	138	9	buffers	buffer	NOUN
ijpds-4738	138	10	may	may	AUX
ijpds-4738	138	11	result	result	VERB
ijpds-4738	138	12	in	in	ADP
ijpds-4738	138	13	chromatographic	chromatographic	ADJ
ijpds-4738	138	14	changes	change	NOUN
ijpds-4738	138	15	,	,	PUNCT
ijpds-4738	138	16	including	include	VERB
ijpds-4738	138	17	greater	great	ADJ
ijpds-4738	138	18	tailing	tailing	NOUN
ijpds-4738	138	19	of	of	ADP
ijpds-4738	138	20	basic	basic	ADJ
ijpds-4738	138	21	compounds	compound	NOUN
ijpds-4738	138	22	and	and	CCONJ
ijpds-4738	138	23	perhaps	perhaps	ADV
ijpds-4738	138	24	different	different	ADJ
ijpds-4738	138	25	selectivity	selectivity	NOUN
ijpds-4738	138	26	.	.	PUNCT
ijpds-4738	139	1	c.	c.	NOUN
ijpds-4738	139	2	ammonium	ammonium	NOUN
ijpds-4738	139	3	salts	salt	NOUN
ijpds-4738	139	4	tend	tend	VERB
ijpds-4738	139	5	to	to	PART
ijpds-4738	139	6	dissolve	dissolve	VERB
ijpds-4738	139	7	more	more	ADV
ijpds-4738	139	8	readily	readily	ADV
ijpds-4738	139	9	in	in	ADP
ijpds-4738	139	10	organic	organic	ADJ
ijpds-4738	139	11	/	/	SYM
ijpds-4738	139	12	h20	h20	NOUN
ijpds-4738	139	13	mobile	mobile	ADJ
ijpds-4738	139	14	phases	phase	NOUN
ijpds-4738	139	15	[	[	X
ijpds-4738	139	16	16	16	NUM
ijpds-4738	139	17	]	]	PUNCT
ijpds-4738	139	18	.	.	PUNCT
ijpds-4738	140	1	b	b	X
ijpds-4738	140	2	)	)	PUNCT
ijpds-4738	140	3	effect	effect	NOUN
ijpds-4738	140	4	of	of	ADP
ijpds-4738	140	5	ph	ph	PROPN
ijpds-4738	140	6	the	the	DET
ijpds-4738	140	7	pka	pka	NOUN
ijpds-4738	140	8	of	of	ADP
ijpds-4738	140	9	the	the	DET
ijpds-4738	140	10	ionizable	ionizable	ADJ
ijpds-4738	140	11	analyte	analyte	NOUN
ijpds-4738	140	12	should	should	AUX
ijpds-4738	140	13	be	be	AUX
ijpds-4738	140	14	used	use	VERB
ijpds-4738	140	15	as	as	ADP
ijpds-4738	140	16	a	a	DET
ijpds-4738	140	17	guide	guide	NOUN
ijpds-4738	140	18	to	to	PART
ijpds-4738	140	19	determine	determine	VERB
ijpds-4738	140	20	the	the	DET
ijpds-4738	140	21	proper	proper	ADJ
ijpds-4738	140	22	mobile	mobile	ADJ
ijpds-4738	140	23	-	-	PUNCT
ijpds-4738	140	24	phase	phase	NOUN
ijpds-4738	140	25	ph	ph	NOUN
ijpds-4738	140	26	.	.	NOUN
ijpds-4738	140	27	by	by	ADP
ijpds-4738	140	28	doing	do	VERB
ijpds-4738	140	29	this	this	PRON
ijpds-4738	140	30	,	,	PUNCT
ijpds-4738	140	31	it	it	PRON
ijpds-4738	140	32	is	be	AUX
ijpds-4738	140	33	guaranteed	guarantee	VERB
ijpds-4738	140	34	that	that	SCONJ
ijpds-4738	140	35	the	the	DET
ijpds-4738	140	36	desired	desire	VERB
ijpds-4738	140	37	analyte	analyte	NOUN
ijpds-4738	140	38	is	be	AUX
ijpds-4738	140	39	ionized	ionize	VERB
ijpds-4738	140	40	or	or	CCONJ
ijpds-4738	140	41	neutral	neutral	ADJ
ijpds-4738	140	42	.	.	PUNCT
ijpds-4738	141	1	one	one	NUM
ijpds-4738	141	2	of	of	ADP
ijpds-4738	141	3	the	the	DET
ijpds-4738	141	4	most	most	ADV
ijpds-4738	141	5	useful	useful	ADJ
ijpds-4738	141	6	tools	tool	NOUN
ijpds-4738	141	7	in	in	ADP
ijpds-4738	141	8	the	the	DET
ijpds-4738	141	9	chromatographer	chromatographer	NOUN
ijpds-4738	141	10	's	's	PART
ijpds-4738	141	11	toolbox	toolbox	NOUN
ijpds-4738	141	12	is	be	AUX
ijpds-4738	141	13	the	the	DET
ijpds-4738	141	14	ability	ability	NOUN
ijpds-4738	141	15	to	to	PART
ijpds-4738	141	16	modify	modify	VERB
ijpds-4738	141	17	the	the	DET
ijpds-4738	141	18	ph	ph	NOUN
ijpds-4738	141	19	of	of	ADP
ijpds-4738	141	20	the	the	DET
ijpds-4738	141	21	mobile	mobile	ADJ
ijpds-4738	141	22	phase	phase	NOUN
ijpds-4738	141	23	.	.	PUNCT
ijpds-4738	142	1	this	this	DET
ijpds-4738	142	2	feature	feature	NOUN
ijpds-4738	142	3	enables	enable	VERB
ijpds-4738	142	4	retention	retention	NOUN
ijpds-4738	142	5	and	and	CCONJ
ijpds-4738	142	6	selectivity	selectivity	NOUN
ijpds-4738	142	7	to	to	PART
ijpds-4738	142	8	be	be	AUX
ijpds-4738	142	9	changed	change	VERB
ijpds-4738	142	10	simultaneously	simultaneously	ADV
ijpds-4738	142	11	,	,	PUNCT
ijpds-4738	142	12	offering	offer	VERB
ijpds-4738	142	13	a	a	DET
ijpds-4738	142	14	tactical	tactical	ADJ
ijpds-4738	142	15	way	way	NOUN
ijpds-4738	142	16	to	to	PART
ijpds-4738	142	17	maximize	maximize	VERB
ijpds-4738	142	18	separation	separation	NOUN
ijpds-4738	142	19	conditions	condition	NOUN
ijpds-4738	142	20	,	,	PUNCT
ijpds-4738	142	21	especially	especially	ADV
ijpds-4738	142	22	for	for	ADP
ijpds-4738	142	23	important	important	ADJ
ijpds-4738	142	24	component	component	NOUN
ijpds-4738	142	25	pairings	pairing	NOUN
ijpds-4738	142	26	in	in	ADP
ijpds-4738	142	27	the	the	DET
ijpds-4738	142	28	sample	sample	NOUN
ijpds-4738	142	29	.	.	PUNCT
ijpds-4738	143	1	in	in	ADP
ijpds-4738	143	2	order	order	NOUN
ijpds-4738	143	3	to	to	PART
ijpds-4738	143	4	customize	customize	VERB
ijpds-4738	143	5	chromatographic	chromatographic	ADJ
ijpds-4738	143	6	conditions	condition	NOUN
ijpds-4738	143	7	and	and	CCONJ
ijpds-4738	143	8	provide	provide	VERB
ijpds-4738	143	9	the	the	DET
ijpds-4738	143	10	required	require	VERB
ijpds-4738	143	11	separation	separation	NOUN
ijpds-4738	143	12	results	result	NOUN
ijpds-4738	143	13	,	,	PUNCT
ijpds-4738	143	14	ph	ph	ADJ
ijpds-4738	143	15	modification	modification	NOUN
ijpds-4738	143	16	is	be	AUX
ijpds-4738	143	17	essential	essential	ADJ
ijpds-4738	143	18	[	[	X
ijpds-4738	143	19	17	17	NUM
ijpds-4738	143	20	]	]	PUNCT
ijpds-4738	143	21	.	.	PUNCT
ijpds-4738	144	1	c	c	X
ijpds-4738	144	2	)	)	PUNCT
ijpds-4738	144	3	effect	effect	NOUN
ijpds-4738	144	4	of	of	ADP
ijpds-4738	144	5	organic	organic	ADJ
ijpds-4738	144	6	modifier	modifier	NOUN
ijpds-4738	144	7	:	:	PUNCT
ijpds-4738	144	8	in	in	ADP
ijpds-4738	144	9	reverse	reverse	ADJ
ijpds-4738	144	10	phase	phase	NOUN
ijpds-4738	144	11	hplc	hplc	NOUN
ijpds-4738	144	12	,	,	PUNCT
ijpds-4738	144	13	choosing	choose	VERB
ijpds-4738	144	14	the	the	DET
ijpds-4738	144	15	kind	kind	NOUN
ijpds-4738	144	16	of	of	ADP
ijpds-4738	144	17	organic	organic	ADJ
ijpds-4738	144	18	modifier	modifier	NOUN
ijpds-4738	144	19	is	be	AUX
ijpds-4738	144	20	rather	rather	ADV
ijpds-4738	144	21	straightforward	straightforward	ADJ
ijpds-4738	144	22	.	.	PUNCT
ijpds-4738	145	1	methanol	methanol	NOUN
ijpds-4738	145	2	and	and	CCONJ
ijpds-4738	145	3	acetonitrile	acetonitrile	NOUN
ijpds-4738	145	4	are	be	AUX
ijpds-4738	145	5	the	the	DET
ijpds-4738	145	6	most	most	ADV
ijpds-4738	145	7	common	common	ADJ
ijpds-4738	145	8	options	option	NOUN
ijpds-4738	145	9	(	(	PUNCT
ijpds-4738	145	10	thf	thf	NOUN
ijpds-4738	145	11	is	be	AUX
ijpds-4738	145	12	rarely	rarely	ADV
ijpds-4738	145	13	used	use	VERB
ijpds-4738	145	14	)	)	PUNCT
ijpds-4738	145	15	.	.	PUNCT
ijpds-4738	146	1	since	since	SCONJ
ijpds-4738	146	2	it	it	PRON
ijpds-4738	146	3	would	would	AUX
ijpds-4738	146	4	not	not	PART
ijpds-4738	146	5	be	be	AUX
ijpds-4738	146	6	possible	possible	ADJ
ijpds-4738	146	7	to	to	PART
ijpds-4738	146	8	elute	elute	VERB
ijpds-4738	146	9	every	every	DET
ijpds-4738	146	10	component	component	NOUN
ijpds-4738	146	11	between	between	ADP
ijpds-4738	146	12	k	k	PROPN
ijpds-4738	146	13	(	(	PUNCT
ijpds-4738	146	14	retention	retention	NOUN
ijpds-4738	146	15	factor	factor	NOUN
ijpds-4738	146	16	)	)	PUNCT
ijpds-4738	146	17	1	1	NUM
ijpds-4738	146	18	and	and	CCONJ
ijpds-4738	146	19	ten	ten	NUM
ijpds-4738	146	20	using	use	VERB
ijpds-4738	146	21	a	a	DET
ijpds-4738	146	22	single	single	ADJ
ijpds-4738	146	23	solvent	solvent	NOUN
ijpds-4738	146	24	strength	strength	NOUN
ijpds-4738	146	25	during	during	ADP
ijpds-4738	146	26	isocratic	isocratic	ADJ
ijpds-4738	146	27	conditions	condition	NOUN
ijpds-4738	146	28	,	,	PUNCT
ijpds-4738	146	29	gradient	gradient	ADJ
ijpds-4738	146	30	elution	elution	NOUN
ijpds-4738	146	31	is	be	AUX
ijpds-4738	146	32	typically	typically	ADV
ijpds-4738	146	33	used	use	VERB
ijpds-4738	146	34	with	with	ADP
ijpds-4738	146	35	complicated	complicated	ADJ
ijpds-4738	146	36	multicomponent	multicomponent	NOUN
ijpds-4738	146	37	samples	sample	NOUN
ijpds-4738	146	38	[	[	X
ijpds-4738	146	39	18	18	NUM
ijpds-4738	146	40	]	]	PUNCT
ijpds-4738	146	41	.	.	PUNCT
ijpds-4738	147	1	choose	choose	VERB
ijpds-4738	147	2	the	the	DET
ijpds-4738	147	3	detector	detector	NOUN
ijpds-4738	147	4	the	the	DET
ijpds-4738	147	5	hplc	hplc	NOUN
ijpds-4738	147	6	's	's	PART
ijpds-4738	147	7	detector	detector	NOUN
ijpds-4738	147	8	is	be	AUX
ijpds-4738	147	9	an	an	DET
ijpds-4738	147	10	essential	essential	ADJ
ijpds-4738	147	11	component	component	NOUN
ijpds-4738	147	12	.	.	PUNCT
ijpds-4738	148	1	the	the	DET
ijpds-4738	148	2	chemical	chemical	NOUN
ijpds-4738	148	3	composition	composition	NOUN
ijpds-4738	148	4	of	of	ADP
ijpds-4738	148	5	the	the	DET
ijpds-4738	148	6	analytes	analyte	NOUN
ijpds-4738	148	7	,	,	PUNCT
ijpds-4738	148	8	potential	potential	ADJ
ijpds-4738	148	9	interference	interference	NOUN
ijpds-4738	148	10	,	,	PUNCT
ijpds-4738	148	11	required	require	VERB
ijpds-4738	148	12	detection	detection	NOUN
ijpds-4738	148	13	limit	limit	NOUN
ijpds-4738	148	14	,	,	PUNCT
ijpds-4738	148	15	detector	detector	NOUN
ijpds-4738	148	16	availability	availability	NOUN
ijpds-4738	148	17	,	,	PUNCT
ijpds-4738	148	18	and/or	and/or	CCONJ
ijpds-4738	148	19	detector	detector	NOUN
ijpds-4738	148	20	cost	cost	NOUN
ijpds-4738	148	21	all	all	PRON
ijpds-4738	148	22	affect	affect	VERB
ijpds-4738	148	23	the	the	DET
ijpds-4738	148	24	detector	detector	NOUN
ijpds-4738	148	25	choice	choice	NOUN
ijpds-4738	148	26	.	.	PUNCT
ijpds-4738	149	1	the	the	DET
ijpds-4738	149	2	uv	uv	NOUN
ijpds-4738	149	3	-	-	PUNCT
ijpds-4738	149	4	visible	visible	ADJ
ijpds-4738	149	5	detector	detector	NOUN
ijpds-4738	149	6	is	be	AUX
ijpds-4738	149	7	a	a	DET
ijpds-4738	149	8	uvvisible	uvvisible	ADJ
ijpds-4738	149	9	dual	dual	ADJ
ijpds-4738	149	10	-	-	PUNCT
ijpds-4738	149	11	wavelength	wavelength	NOUN
ijpds-4738	149	12	absorbance	absorbance	NOUN
ijpds-4738	149	13	detector	detector	NOUN
ijpds-4738	149	14	that	that	PRON
ijpds-4738	149	15	is	be	AUX
ijpds-4738	149	16	flexible	flexible	ADJ
ijpds-4738	149	17	and	and	CCONJ
ijpds-4738	149	18	stays	stay	VERB
ijpds-4738	149	19	hplc	hplc	NOUN
ijpds-4738	149	20	.	.	PUNCT
ijpds-4738	150	1	the	the	DET
ijpds-4738	150	2	high	high	ADJ
ijpds-4738	150	3	sensitivity	sensitivity	NOUN
ijpds-4738	150	4	of	of	ADP
ijpds-4738	150	5	this	this	DET
ijpds-4738	150	6	detector	detector	NOUN
ijpds-4738	150	7	is	be	AUX
ijpds-4738	150	8	required	require	VERB
ijpds-4738	150	9	for	for	ADP
ijpds-4738	150	10	routine	routine	ADJ
ijpds-4738	150	11	uv	uv	NOUN
ijpds-4738	150	12	-	-	PUNCT
ijpds-4738	150	13	based	base	VERB
ijpds-4738	150	14	applications	application	NOUN
ijpds-4738	150	15	,	,	PUNCT
ijpds-4738	150	16	such	such	ADJ
ijpds-4738	150	17	as	as	ADP
ijpds-4738	150	18	low	low	ADJ
ijpds-4738	150	19	-	-	PUNCT
ijpds-4738	150	20	level	level	NOUN
ijpds-4738	150	21	impurity	impurity	NOUN
ijpds-4738	150	22	detection	detection	NOUN
ijpds-4738	150	23	and	and	CCONJ
ijpds-4738	150	24	quantitative	quantitative	ADJ
ijpds-4738	150	25	analysis	analysis	NOUN
ijpds-4738	150	26	.	.	PUNCT
ijpds-4738	151	1	the	the	DET
ijpds-4738	151	2	photodiode	photodiode	NOUN
ijpds-4738	151	3	array	array	NOUN
ijpds-4738	151	4	(	(	PUNCT
ijpds-4738	151	5	pda	pda	NOUN
ijpds-4738	151	6	)	)	PUNCT
ijpds-4738	151	7	detector	detector	NOUN
ijpds-4738	151	8	offers	offer	VERB
ijpds-4738	151	9	advanced	advanced	ADJ
ijpds-4738	151	10	optical	optical	ADJ
ijpds-4738	151	11	detection	detection	NOUN
ijpds-4738	151	12	with	with	ADP
ijpds-4738	151	13	aqueous	aqueous	ADJ
ijpds-4738	151	14	analytical	analytical	ADJ
ijpds-4738	151	15	hplc	hplc	NOUN
ijpds-4738	151	16	,	,	PUNCT
ijpds-4738	151	17	preparative	preparative	ADJ
ijpds-4738	151	18	hplc	hplc	NOUN
ijpds-4738	151	19	,	,	PUNCT
ijpds-4738	151	20	or	or	CCONJ
ijpds-4738	151	21	lc	lc	PROPN
ijpds-4738	151	22	/	/	SYM
ijpds-4738	151	23	ms	ms	NOUN
ijpds-4738	151	24	system	system	NOUN
ijpds-4738	151	25	solutions	solution	NOUN
ijpds-4738	151	26	.	.	PUNCT
ijpds-4738	152	1	the	the	DET
ijpds-4738	152	2	developments	development	NOUN
ijpds-4738	152	3	in	in	ADP
ijpds-4738	152	4	optics	optic	NOUN
ijpds-4738	152	5	and	and	CCONJ
ijpds-4738	152	6	integrated	integrate	VERB
ijpds-4738	152	7	software	software	NOUN
ijpds-4738	152	8	allow	allow	VERB
ijpds-4738	152	9	for	for	ADP
ijpds-4738	152	10	the	the	DET
ijpds-4738	152	11	achievement	achievement	NOUN
ijpds-4738	152	12	of	of	ADP
ijpds-4738	152	13	high	high	ADJ
ijpds-4738	152	14	spectrum	spectrum	NOUN
ijpds-4738	152	15	and	and	CCONJ
ijpds-4738	152	16	chromatic	chromatic	ADJ
ijpds-4738	152	17	sensitivity	sensitivity	NOUN
ijpds-4738	152	18	.	.	PUNCT
ijpds-4738	153	1	the	the	DET
ijpds-4738	153	2	ideal	ideal	ADJ
ijpds-4738	153	3	choice	choice	NOUN
ijpds-4738	153	4	for	for	ADP
ijpds-4738	153	5	analysing	analyse	VERB
ijpds-4738	153	6	components	component	NOUN
ijpds-4738	153	7	with	with	ADP
ijpds-4738	153	8	little	little	ADJ
ijpds-4738	153	9	to	to	ADP
ijpds-4738	153	10	no	no	DET
ijpds-4738	153	11	uv	uv	NOUN
ijpds-4738	153	12	absorption	absorption	NOUN
ijpds-4738	153	13	is	be	AUX
ijpds-4738	153	14	the	the	DET
ijpds-4738	153	15	refractive	refractive	ADJ
ijpds-4738	153	16	index	index	NOUN
ijpds-4738	153	17	(	(	PUNCT
ijpds-4738	153	18	ri	ri	NOUN
ijpds-4738	153	19	)	)	PUNCT
ijpds-4738	153	20	detecting	detect	VERB
ijpds-4738	153	21	device	device	NOUN
ijpds-4738	153	22	because	because	SCONJ
ijpds-4738	153	23	of	of	ADP
ijpds-4738	153	24	its	its	PRON
ijpds-4738	153	25	exceptional	exceptional	ADJ
ijpds-4738	153	26	sensitivity	sensitivity	NOUN
ijpds-4738	153	27	,	,	PUNCT
ijpds-4738	153	28	stability	stability	NOUN
ijpds-4738	153	29	,	,	PUNCT
ijpds-4738	153	30	and	and	CCONJ
ijpds-4738	153	31	reproducibility	reproducibility	NOUN
ijpds-4738	153	32	.	.	PUNCT
ijpds-4738	154	1	the	the	DET
ijpds-4738	154	2	multiwavelength	multiwavelength	NOUN
ijpds-4738	154	3	fluorescence	fluorescence	NOUN
ijpds-4738	154	4	detector	detector	NOUN
ijpds-4738	154	5	can	can	AUX
ijpds-4738	154	6	measure	measure	VERB
ijpds-4738	154	7	minute	minute	ADJ
ijpds-4738	154	8	quantities	quantity	NOUN
ijpds-4738	154	9	of	of	ADP
ijpds-4738	154	10	target	target	NOUN
ijpds-4738	154	11	chemicals	chemical	NOUN
ijpds-4738	154	12	and	and	CCONJ
ijpds-4738	154	13	offers	offer	VERB
ijpds-4738	154	14	high	high	ADJ
ijpds-4738	154	15	sensitivity	sensitivity	NOUN
ijpds-4738	154	16	and	and	CCONJ
ijpds-4738	154	17	selectivity	selectivity	NOUN
ijpds-4738	154	18	fluorescence	fluorescence	NOUN
ijpds-4738	154	19	detection	detection	NOUN
ijpds-4738	154	20	[	[	X
ijpds-4738	154	21	19	19	NUM
ijpds-4738	154	22	,	,	PUNCT
ijpds-4738	154	23	20	20	NUM
ijpds-4738	154	24	]	]	PUNCT
ijpds-4738	154	25	.	.	PUNCT
ijpds-4738	155	1	technique	technique	NOUN
ijpds-4738	155	2	of	of	ADP
ijpds-4738	155	3	separation	separation	NOUN
ijpds-4738	155	4	a	a	PRON
ijpds-4738	155	5	)	)	PUNCT
ijpds-4738	155	6	isocratic	isocratic	ADJ
ijpds-4738	155	7	separations	separation	NOUN
ijpds-4738	155	8	analyte	analyte	NOUN
ijpds-4738	155	9	-	-	PUNCT
ijpds-4738	155	10	eluent	eluent	NOUN
ijpds-4738	155	11	and	and	CCONJ
ijpds-4738	155	12	analyte	analyte	NOUN
ijpds-4738	155	13	-	-	PUNCT
ijpds-4738	155	14	stationary	stationary	ADJ
ijpds-4738	155	15	-	-	PUNCT
ijpds-4738	155	16	phase	phase	NOUN
ijpds-4738	155	17	interactions	interaction	NOUN
ijpds-4738	155	18	remain	remain	VERB
ijpds-4738	155	19	stable	stable	ADJ
ijpds-4738	155	20	over	over	ADP
ijpds-4738	155	21	the	the	DET
ijpds-4738	155	22	course	course	NOUN
ijpds-4738	155	23	of	of	ADP
ijpds-4738	155	24	the	the	DET
ijpds-4738	155	25	run	run	NOUN
ijpds-4738	155	26	when	when	SCONJ
ijpds-4738	155	27	there	there	PRON
ijpds-4738	155	28	is	be	VERB
ijpds-4738	155	29	an	an	DET
ijpds-4738	155	30	isocratic	isocratic	ADJ
ijpds-4738	155	31	,	,	PUNCT
ijpds-4738	155	32	constant	constant	ADJ
ijpds-4738	155	33	eluent	eluent	NOUN
ijpds-4738	155	34	composition	composition	NOUN
ijpds-4738	155	35	.	.	PUNCT
ijpds-4738	156	1	this	this	PRON
ijpds-4738	156	2	also	also	ADV
ijpds-4738	156	3	guarantees	guarantee	VERB
ijpds-4738	156	4	equilibrium	equilibrium	NOUN
ijpds-4738	156	5	conditions	condition	NOUN
ijpds-4738	156	6	in	in	ADP
ijpds-4738	156	7	the	the	DET
ijpds-4738	156	8	column	column	NOUN
ijpds-4738	156	9	and	and	CCONJ
ijpds-4738	156	10	the	the	DET
ijpds-4738	156	11	real	real	ADJ
ijpds-4738	156	12	velocity	velocity	NOUN
ijpds-4738	156	13	of	of	ADP
ijpds-4738	156	14	compounds	compound	NOUN
ijpds-4738	156	15	flowing	flow	VERB
ijpds-4738	156	16	through	through	ADP
ijpds-4738	156	17	the	the	DET
ijpds-4738	156	18	column	column	NOUN
ijpds-4738	156	19	.	.	PUNCT
ijpds-4738	157	1	despite	despite	SCONJ
ijpds-4738	157	2	the	the	DET
ijpds-4738	157	3	low	low	ADJ
ijpds-4738	157	4	separation	separation	NOUN
ijpds-4738	157	5	power	power	NOUN
ijpds-4738	157	6	—	—	PUNCT
ijpds-4738	157	7	the	the	DET
ijpds-4738	157	8	amount	amount	NOUN
ijpds-4738	157	9	of	of	ADP
ijpds-4738	157	10	compounds	compound	NOUN
ijpds-4738	157	11	that	that	PRON
ijpds-4738	157	12	might	might	AUX
ijpds-4738	157	13	be	be	AUX
ijpds-4738	157	14	resolved	resolve	VERB
ijpds-4738	157	15	—	—	PUNCT
ijpds-4738	157	16	this	this	PRON
ijpds-4738	157	17	increases	increase	VERB
ijpds-4738	157	18	the	the	DET
ijpds-4738	157	19	predictability	predictability	NOUN
ijpds-4738	157	20	of	of	ADP
ijpds-4738	157	21	isocratic	isocratic	ADJ
ijpds-4738	157	22	separations	separation	NOUN
ijpds-4738	157	23	.	.	PUNCT
ijpds-4738	158	1	the	the	DET
ijpds-4738	158	2	peak	peak	NOUN
ijpds-4738	158	3	capacity	capacity	NOUN
ijpds-4738	158	4	is	be	AUX
ijpds-4738	158	5	modest	modest	ADJ
ijpds-4738	158	6	,	,	PUNCT
ijpds-4738	158	7	and	and	CCONJ
ijpds-4738	158	8	the	the	DET
ijpds-4738	158	9	resulting	result	VERB
ijpds-4738	158	10	peak	peak	NOUN
ijpds-4738	158	11	widens	widen	VERB
ijpds-4738	158	12	as	as	ADP
ijpds-4738	158	13	the	the	DET
ijpds-4738	158	14	length	length	NOUN
ijpds-4738	158	15	of	of	ADP
ijpds-4738	158	16	time	time	NOUN
ijpds-4738	158	17	the	the	DET
ijpds-4738	158	18	component	component	NOUN
ijpds-4738	158	19	is	be	AUX
ijpds-4738	158	20	kept	keep	VERB
ijpds-4738	158	21	on	on	ADP
ijpds-4738	158	22	the	the	DET
ijpds-4738	158	23	column	column	NOUN
ijpds-4738	158	24	[	[	X
ijpds-4738	158	25	21	21	NUM
ijpds-4738	158	26	]	]	PUNCT
ijpds-4738	158	27	.	.	PUNCT
ijpds-4738	159	1	b	b	X
ijpds-4738	159	2	)	)	PUNCT
ijpds-4738	159	3	gradient	gradient	NOUN
ijpds-4738	159	4	separation	separation	NOUN
ijpds-4738	159	5	a	a	DET
ijpds-4738	159	6	system	system	NOUN
ijpds-4738	159	7	's	's	PART
ijpds-4738	159	8	separation	separation	NOUN
ijpds-4738	159	9	power	power	NOUN
ijpds-4738	159	10	is	be	AUX
ijpds-4738	159	11	greatly	greatly	ADV
ijpds-4738	159	12	increased	increase	VERB
ijpds-4738	159	13	by	by	ADP
ijpds-4738	159	14	gradient	gradient	NOUN
ijpds-4738	159	15	separation	separation	NOUN
ijpds-4738	159	16	,	,	PUNCT
ijpds-4738	159	17	mostly	mostly	ADV
ijpds-4738	159	18	due	due	ADP
ijpds-4738	159	19	to	to	ADP
ijpds-4738	159	20	the	the	DET
ijpds-4738	159	21	abrupt	abrupt	ADJ
ijpds-4738	159	22	rise	rise	NOUN
ijpds-4738	159	23	in	in	ADP
ijpds-4738	159	24	apparent	apparent	ADJ
ijpds-4738	159	25	efficiency	efficiency	NOUN
ijpds-4738	159	26	(	(	PUNCT
ijpds-4738	159	27	reduction	reduction	NOUN
ijpds-4738	159	28	in	in	ADP
ijpds-4738	159	29	peak	peak	NOUN
ijpds-4738	159	30	width	width	NOUN
ijpds-4738	159	31	)	)	PUNCT
ijpds-4738	159	32	.	.	PUNCT
ijpds-4738	160	1	peak	peak	NOUN
ijpds-4738	160	2	width	width	NOUN
ijpds-4738	160	3	decreases	decrease	NOUN
ijpds-4738	160	4	in	in	ADP
ijpds-4738	160	5	the	the	DET
ijpds-4738	160	6	situation	situation	NOUN
ijpds-4738	160	7	when	when	SCONJ
ijpds-4738	160	8	the	the	DET
ijpds-4738	160	9	chromatographic	chromatographic	ADJ
ijpds-4738	160	10	zone	zone	NOUN
ijpds-4738	160	11	's	's	PART
ijpds-4738	160	12	tail	tail	NOUN
ijpds-4738	160	13	is	be	AUX
ijpds-4738	160	14	constantly	constantly	ADV
ijpds-4738	160	15	affected	affect	VERB
ijpds-4738	160	16	by	by	ADP
ijpds-4738	160	17	a	a	DET
ijpds-4738	160	18	more	more	ADV
ijpds-4738	160	19	potent	potent	ADJ
ijpds-4738	160	20	eluent	eluent	NOUN
ijpds-4738	160	21	composition	composition	NOUN
ijpds-4738	160	22	.	.	PUNCT
ijpds-4738	161	1	peak	peak	NOUN
ijpds-4738	161	2	width	width	NOUN
ijpds-4738	161	3	is	be	AUX
ijpds-4738	161	4	a	a	DET
ijpds-4738	161	5	function	function	NOUN
ijpds-4738	161	6	of	of	ADP
ijpds-4738	161	7	gradient	gradient	ADJ
ijpds-4738	161	8	slope	slope	NOUN
ijpds-4738	161	9	,	,	PUNCT
ijpds-4738	161	10	which	which	PRON
ijpds-4738	161	11	measures	measure	VERB
ijpds-4738	161	12	how	how	SCONJ
ijpds-4738	161	13	quickly	quickly	ADV
ijpds-4738	161	14	the	the	DET
ijpds-4738	161	15	eluent	eluent	NOUN
ijpds-4738	161	16	composition	composition	NOUN
ijpds-4738	161	17	changes	change	NOUN
ijpds-4738	161	18	.	.	PUNCT
ijpds-4738	162	1	shifting	shift	VERB
ijpds-4738	162	2	the	the	DET
ijpds-4738	162	3	gradient	gradient	NOUN
ijpds-4738	162	4	since	since	SCONJ
ijpds-4738	162	5	it	it	PRON
ijpds-4738	162	6	might	might	AUX
ijpds-4738	162	7	not	not	PART
ijpds-4738	162	8	be	be	AUX
ijpds-4738	162	9	possible	possible	ADJ
ijpds-4738	162	10	to	to	PART
ijpds-4738	162	11	elute	elute	VERB
ijpds-4738	162	12	every	every	DET
ijpds-4738	162	13	component	component	NOUN
ijpds-4738	162	14	between	between	ADP
ijpds-4738	162	15	k	k	PROPN
ijpds-4738	162	16	patil	patil	PROPN
ijpds-4738	162	17	et	et	PROPN
ijpds-4738	162	18	al	al	PROPN
ijpds-4738	162	19	.	.	PROPN
ijpds-4738	162	20	analytical	analytical	ADJ
ijpds-4738	162	21	method	method	PROPN
ijpds-4738	162	22	development	development	NOUN
ijpds-4738	162	23	and	and	CCONJ
ijpds-4738	162	24	validation	validation	NOUN
ijpds-4738	162	25	online	online	ADJ
ijpds-4738	162	26	first	first	PROPN
ijpds-4738	162	27	indian	indian	PROPN
ijpds-4738	162	28	j	j	PROPN
ijpds-4738	162	29	pharm	pharm	PROPN
ijpds-4738	162	30	drug	drug	PROPN
ijpds-4738	162	31	studies	study	NOUN
ijpds-4738	162	32	|	|	ADV
ijpds-4738	162	33	4	4	NUM
ijpds-4738	162	34	(	(	PUNCT
ijpds-4738	162	35	retention	retention	NOUN
ijpds-4738	162	36	factor	factor	NOUN
ijpds-4738	162	37	)	)	PUNCT
ijpds-4738	162	38	from	from	ADP
ijpds-4738	162	39	1	1	NUM
ijpds-4738	162	40	to	to	PART
ijpds-4738	162	41	10	10	NUM
ijpds-4738	162	42	using	use	VERB
ijpds-4738	162	43	only	only	ADV
ijpds-4738	162	44	one	one	NUM
ijpds-4738	162	45	solvent	solvent	NOUN
ijpds-4738	162	46	's	's	PART
ijpds-4738	162	47	strength	strength	NOUN
ijpds-4738	162	48	during	during	ADP
ijpds-4738	162	49	isocratic	isocratic	ADJ
ijpds-4738	162	50	conditions	condition	NOUN
ijpds-4738	162	51	,	,	PUNCT
ijpds-4738	162	52	gradient	gradient	ADJ
ijpds-4738	162	53	elution	elution	NOUN
ijpds-4738	162	54	is	be	AUX
ijpds-4738	162	55	used	use	VERB
ijpds-4738	162	56	for	for	ADP
ijpds-4738	162	57	complicated	complicated	ADJ
ijpds-4738	162	58	multicomponent	multicomponent	NOUN
ijpds-4738	162	59	samples	sample	NOUN
ijpds-4738	162	60	.	.	PUNCT
ijpds-4738	163	1	if	if	SCONJ
ijpds-4738	163	2	the	the	DET
ijpds-4738	163	3	ratio	ratio	NOUN
ijpds-4738	163	4	is	be	AUX
ijpds-4738	163	5	less	less	ADJ
ijpds-4738	163	6	than	than	ADP
ijpds-4738	163	7	0.25	0.25	NUM
ijpds-4738	163	8	,	,	PUNCT
ijpds-4738	163	9	isocratic	isocratic	NOUN
ijpds-4738	163	10	would	would	AUX
ijpds-4738	163	11	be	be	AUX
ijpds-4738	163	12	sufficient	sufficient	ADJ
ijpds-4738	163	13	;	;	PUNCT
ijpds-4738	163	14	if	if	SCONJ
ijpds-4738	163	15	it	it	PRON
ijpds-4738	163	16	is	be	AUX
ijpds-4738	163	17	greater	great	ADJ
ijpds-4738	163	18	than	than	ADP
ijpds-4738	163	19	0.25	0.25	NUM
ijpds-4738	163	20	,	,	PUNCT
ijpds-4738	163	21	gradient	gradient	NOUN
ijpds-4738	163	22	will	will	AUX
ijpds-4738	163	23	be	be	AUX
ijpds-4738	163	24	advantageous	advantageous	ADJ
ijpds-4738	163	25	[	[	X
ijpds-4738	163	26	22	22	NUM
ijpds-4738	163	27	,	,	PUNCT
ijpds-4738	163	28	23	23	NUM
ijpds-4738	163	29	]	]	PUNCT
ijpds-4738	163	30	.	.	PUNCT
ijpds-4738	164	1	preparing	prepare	VERB
ijpds-4738	164	2	samples	sample	NOUN
ijpds-4738	164	3	for	for	ADP
ijpds-4738	164	4	technique	technique	NOUN
ijpds-4738	164	5	development	development	NOUN
ijpds-4738	164	6	it	it	PRON
ijpds-4738	164	7	is	be	AUX
ijpds-4738	164	8	necessary	necessary	ADJ
ijpds-4738	164	9	for	for	ADP
ijpds-4738	164	10	the	the	DET
ijpds-4738	164	11	drug	drug	NOUN
ijpds-4738	164	12	material	material	NOUN
ijpds-4738	164	13	under	under	ADP
ijpds-4738	164	14	analysis	analysis	NOUN
ijpds-4738	164	15	to	to	PART
ijpds-4738	164	16	be	be	AUX
ijpds-4738	164	17	stable	stable	ADJ
ijpds-4738	164	18	in	in	ADP
ijpds-4738	164	19	solution	solution	NOUN
ijpds-4738	164	20	(	(	PUNCT
ijpds-4738	164	21	diluent	diluent	NOUN
ijpds-4738	164	22	)	)	PUNCT
ijpds-4738	164	23	.	.	PUNCT
ijpds-4738	165	1	the	the	DET
ijpds-4738	165	2	solutions	solution	NOUN
ijpds-4738	165	3	should	should	AUX
ijpds-4738	165	4	be	be	AUX
ijpds-4738	165	5	prepared	prepare	VERB
ijpds-4738	165	6	in	in	ADP
ijpds-4738	165	7	amber	amber	PROPN
ijpds-4738	165	8	flasks	flask	NOUN
ijpds-4738	165	9	during	during	ADP
ijpds-4738	165	10	the	the	DET
ijpds-4738	165	11	early	early	ADJ
ijpds-4738	165	12	stages	stage	NOUN
ijpds-4738	165	13	of	of	ADP
ijpds-4738	165	14	method	method	NOUN
ijpds-4738	165	15	development	development	NOUN
ijpds-4738	165	16	until	until	SCONJ
ijpds-4738	165	17	it	it	PRON
ijpds-4738	165	18	is	be	AUX
ijpds-4738	165	19	shown	show	VERB
ijpds-4738	165	20	that	that	SCONJ
ijpds-4738	165	21	the	the	DET
ijpds-4738	165	22	active	active	ADJ
ijpds-4738	165	23	ingredient	ingredient	NOUN
ijpds-4738	165	24	is	be	AUX
ijpds-4738	165	25	stable	stable	ADJ
ijpds-4738	165	26	at	at	ADP
ijpds-4738	165	27	room	room	NOUN
ijpds-4738	165	28	temperature	temperature	NOUN
ijpds-4738	165	29	and	and	CCONJ
ijpds-4738	165	30	does	do	AUX
ijpds-4738	165	31	not	not	PART
ijpds-4738	165	32	deteriorate	deteriorate	VERB
ijpds-4738	165	33	under	under	ADP
ijpds-4738	165	34	typical	typical	ADJ
ijpds-4738	165	35	laboratory	laboratory	NOUN
ijpds-4738	165	36	circumstances	circumstance	NOUN
ijpds-4738	165	37	.	.	PUNCT
ijpds-4738	166	1	it	it	PRON
ijpds-4738	166	2	is	be	AUX
ijpds-4738	166	3	advised	advise	VERB
ijpds-4738	166	4	to	to	PART
ijpds-4738	166	5	filter	filter	VERB
ijpds-4738	166	6	the	the	DET
ijpds-4738	166	7	sample	sample	NOUN
ijpds-4738	166	8	solution	solution	NOUN
ijpds-4738	166	9	using	use	VERB
ijpds-4738	166	10	0.22	0.22	NUM
ijpds-4738	166	11	/	/	SYM
ijpds-4738	166	12	0.45	0.45	NUM
ijpds-4738	166	13	µm	µm	ADP
ijpds-4738	166	14	pore	pore	ADJ
ijpds-4738	166	15	-	-	PUNCT
ijpds-4738	166	16	size	size	NOUN
ijpds-4738	166	17	filtration	filtration	NOUN
ijpds-4738	166	18	to	to	PART
ijpds-4738	166	19	remove	remove	VERB
ijpds-4738	166	20	any	any	DET
ijpds-4738	166	21	particles	particle	NOUN
ijpds-4738	166	22	.	.	PUNCT
ijpds-4738	167	1	for	for	ADP
ijpds-4738	167	2	hplc	hplc	NOUN
ijpds-4738	167	3	analysis	analysis	NOUN
ijpds-4738	167	4	,	,	PUNCT
ijpds-4738	167	5	filtration	filtration	NOUN
ijpds-4738	167	6	is	be	AUX
ijpds-4738	167	7	a	a	DET
ijpds-4738	167	8	preventative	preventative	ADJ
ijpds-4738	167	9	maintenance	maintenance	NOUN
ijpds-4738	167	10	technique	technique	NOUN
ijpds-4738	167	11	[	[	X
ijpds-4738	167	12	24	24	NUM
ijpds-4738	167	13	,	,	PUNCT
ijpds-4738	167	14	25	25	NUM
ijpds-4738	167	15	]	]	PUNCT
ijpds-4738	167	16	.	.	PUNCT
ijpds-4738	168	1	optimization	optimization	NOUN
ijpds-4738	168	2	of	of	ADP
ijpds-4738	168	3	methods	method	NOUN
ijpds-4738	168	4	determine	determine	VERB
ijpds-4738	168	5	the	the	DET
ijpds-4738	168	6	shortcomings	shortcoming	NOUN
ijpds-4738	168	7	of	of	ADP
ijpds-4738	168	8	approach	approach	NOUN
ijpds-4738	168	9	and	and	CCONJ
ijpds-4738	168	10	use	use	VERB
ijpds-4738	168	11	experimental	experimental	ADJ
ijpds-4738	168	12	design	design	NOUN
ijpds-4738	168	13	to	to	PART
ijpds-4738	168	14	strengthen	strengthen	VERB
ijpds-4738	168	15	it	it	PRON
ijpds-4738	168	16	.	.	PUNCT
ijpds-4738	169	1	evaluate	evaluate	VERB
ijpds-4738	169	2	the	the	DET
ijpds-4738	169	3	approach	approach	NOUN
ijpds-4738	169	4	's	's	PART
ijpds-4738	169	5	effects	effect	NOUN
ijpds-4738	169	6	on	on	ADP
ijpds-4738	169	7	different	different	ADJ
ijpds-4738	169	8	samples	sample	NOUN
ijpds-4738	169	9	,	,	PUNCT
ijpds-4738	169	10	equipment	equipment	NOUN
ijpds-4738	169	11	setups	setup	NOUN
ijpds-4738	169	12	,	,	PUNCT
ijpds-4738	169	13	and	and	CCONJ
ijpds-4738	169	14	environmental	environmental	ADJ
ijpds-4738	169	15	conditions	condition	NOUN
ijpds-4738	169	16	.	.	PUNCT
ijpds-4738	170	1	this	this	DET
ijpds-4738	170	2	iterative	iterative	NOUN
ijpds-4738	170	3	process	process	NOUN
ijpds-4738	170	4	aids	aid	NOUN
ijpds-4738	170	5	in	in	ADP
ijpds-4738	170	6	the	the	DET
ijpds-4738	170	7	methodology	methodology	NOUN
ijpds-4738	170	8	's	's	PART
ijpds-4738	170	9	improvement	improvement	NOUN
ijpds-4738	170	10	and	and	CCONJ
ijpds-4738	170	11	ensures	ensure	VERB
ijpds-4738	170	12	that	that	SCONJ
ijpds-4738	170	13	high	high	ADJ
ijpds-4738	170	14	-	-	PUNCT
ijpds-4738	170	15	performance	performance	NOUN
ijpds-4738	170	16	liquid	liquid	ADJ
ijpds-4738	170	17	chromatography	chromatography	NOUN
ijpds-4738	170	18	(	(	PUNCT
ijpds-4738	170	19	hplc	hplc	NOUN
ijpds-4738	170	20	)	)	PUNCT
ijpds-4738	170	21	analysis	analysis	NOUN
ijpds-4738	170	22	is	be	AUX
ijpds-4738	170	23	robust	robust	ADJ
ijpds-4738	170	24	,	,	PUNCT
ijpds-4738	170	25	reliable	reliable	ADJ
ijpds-4738	170	26	,	,	PUNCT
ijpds-4738	170	27	and	and	CCONJ
ijpds-4738	170	28	applicable	applicable	ADJ
ijpds-4738	170	29	under	under	ADP
ijpds-4738	170	30	a	a	DET
ijpds-4738	170	31	variety	variety	NOUN
ijpds-4738	170	32	of	of	ADP
ijpds-4738	170	33	conditions	condition	NOUN
ijpds-4738	170	34	[	[	X
ijpds-4738	170	35	26	26	NUM
ijpds-4738	170	36	]	]	PUNCT
ijpds-4738	170	37	.	.	PUNCT
ijpds-4738	171	1	validation	validation	NOUN
ijpds-4738	171	2	of	of	ADP
ijpds-4738	171	3	methods	method	NOUN
ijpds-4738	171	4	the	the	DET
ijpds-4738	171	5	procedure	procedure	NOUN
ijpds-4738	171	6	of	of	ADP
ijpds-4738	171	7	laboratory	laboratory	NOUN
ijpds-4738	171	8	testing	testing	NOUN
ijpds-4738	171	9	is	be	AUX
ijpds-4738	171	10	carried	carry	VERB
ijpds-4738	171	11	out	out	ADP
ijpds-4738	171	12	to	to	PART
ijpds-4738	171	13	show	show	VERB
ijpds-4738	171	14	that	that	SCONJ
ijpds-4738	171	15	an	an	DET
ijpds-4738	171	16	analytical	analytical	ADJ
ijpds-4738	171	17	method	method	NOUN
ijpds-4738	171	18	's	's	PART
ijpds-4738	171	19	performance	performance	NOUN
ijpds-4738	171	20	characteristics	characteristic	NOUN
ijpds-4738	171	21	match	match	VERB
ijpds-4738	171	22	the	the	DET
ijpds-4738	171	23	demands	demand	NOUN
ijpds-4738	171	24	of	of	ADP
ijpds-4738	171	25	the	the	DET
ijpds-4738	171	26	planned	plan	VERB
ijpds-4738	171	27	analytical	analytical	ADJ
ijpds-4738	171	28	application	application	NOUN
ijpds-4738	171	29	is	be	AUX
ijpds-4738	171	30	known	know	VERB
ijpds-4738	171	31	as	as	ADP
ijpds-4738	171	32	validation	validation	NOUN
ijpds-4738	171	33	.	.	PUNCT
ijpds-4738	172	1	any	any	DET
ijpds-4738	172	2	new	new	ADJ
ijpds-4738	172	3	or	or	CCONJ
ijpds-4738	172	4	revised	revise	VERB
ijpds-4738	172	5	procedure	procedure	NOUN
ijpds-4738	172	6	has	have	VERB
ijpds-4738	172	7	to	to	PART
ijpds-4738	172	8	be	be	AUX
ijpds-4738	172	9	validated	validate	VERB
ijpds-4738	172	10	to	to	PART
ijpds-4738	172	11	make	make	VERB
ijpds-4738	172	12	sure	sure	ADJ
ijpds-4738	172	13	it	it	PRON
ijpds-4738	172	14	consistently	consistently	ADV
ijpds-4738	172	15	yields	yield	VERB
ijpds-4738	172	16	reproducible	reproducible	VERB
ijpds-4738	172	17	and	and	CCONJ
ijpds-4738	172	18	trustworthy	trustworthy	ADJ
ijpds-4738	172	19	results	result	NOUN
ijpds-4738	172	20	,	,	PUNCT
ijpds-4738	172	21	regardless	regardless	ADV
ijpds-4738	172	22	of	of	ADP
ijpds-4738	172	23	whether	whether	SCONJ
ijpds-4738	172	24	it	it	PRON
ijpds-4738	172	25	is	be	AUX
ijpds-4738	172	26	performed	perform	VERB
ijpds-4738	172	27	by	by	ADP
ijpds-4738	172	28	several	several	ADJ
ijpds-4738	172	29	operators	operator	NOUN
ijpds-4738	172	30	in	in	ADP
ijpds-4738	172	31	various	various	ADJ
ijpds-4738	172	32	laboratories	laboratory	NOUN
ijpds-4738	172	33	using	use	VERB
ijpds-4738	172	34	the	the	DET
ijpds-4738	172	35	same	same	ADJ
ijpds-4738	172	36	utilizing	utilize	VERB
ijpds-4738	172	37	equipment	equipment	NOUN
ijpds-4738	172	38	that	that	PRON
ijpds-4738	172	39	satisfies	satisfy	VERB
ijpds-4738	172	40	requirements	requirement	NOUN
ijpds-4738	172	41	,	,	PUNCT
ijpds-4738	172	42	is	be	AUX
ijpds-4738	172	43	operational	operational	ADJ
ijpds-4738	172	44	,	,	PUNCT
ijpds-4738	172	45	functional	functional	ADJ
ijpds-4738	172	46	,	,	PUNCT
ijpds-4738	172	47	and	and	CCONJ
ijpds-4738	172	48	accurately	accurately	ADV
ijpds-4738	172	49	calibrated	calibrate	VERB
ijpds-4738	172	50	is	be	AUX
ijpds-4738	172	51	crucial	crucial	ADJ
ijpds-4738	172	52	to	to	ADP
ijpds-4738	172	53	the	the	DET
ijpds-4738	172	54	validation	validation	NOUN
ijpds-4738	172	55	process	process	NOUN
ijpds-4738	172	56	.	.	PUNCT
ijpds-4738	173	1	analytical	analytical	ADJ
ijpds-4738	173	2	methods	method	NOUN
ijpds-4738	173	3	are	be	AUX
ijpds-4738	173	4	carefully	carefully	ADV
ijpds-4738	173	5	examined	examine	VERB
ijpds-4738	173	6	during	during	ADP
ijpds-4738	173	7	the	the	DET
ijpds-4738	173	8	validation	validation	NOUN
ijpds-4738	173	9	process	process	NOUN
ijpds-4738	173	10	,	,	PUNCT
ijpds-4738	173	11	after	after	ADP
ijpds-4738	173	12	which	which	PRON
ijpds-4738	173	13	they	they	PRON
ijpds-4738	173	14	are	be	AUX
ijpds-4738	173	15	either	either	ADV
ijpds-4738	173	16	approved	approve	VERB
ijpds-4738	173	17	for	for	ADP
ijpds-4738	173	18	use	use	NOUN
ijpds-4738	173	19	or	or	CCONJ
ijpds-4738	173	20	rejected	reject	VERB
ijpds-4738	173	21	if	if	SCONJ
ijpds-4738	173	22	they	they	PRON
ijpds-4738	173	23	do	do	AUX
ijpds-4738	173	24	n't	not	PART
ijpds-4738	173	25	match	match	VERB
ijpds-4738	173	26	the	the	DET
ijpds-4738	173	27	necessary	necessary	ADJ
ijpds-4738	173	28	standards	standard	NOUN
ijpds-4738	173	29	.	.	PUNCT
ijpds-4738	174	1	this	this	PRON
ijpds-4738	174	2	ensures	ensure	VERB
ijpds-4738	174	3	the	the	DET
ijpds-4738	174	4	correctness	correctness	NOUN
ijpds-4738	174	5	and	and	CCONJ
ijpds-4738	174	6	dependability	dependability	NOUN
ijpds-4738	174	7	for	for	ADP
ijpds-4738	174	8	statistical	statistical	ADJ
ijpds-4738	174	9	results	result	NOUN
ijpds-4738	174	10	in	in	ADP
ijpds-4738	174	11	multiple	multiple	ADJ
ijpds-4738	174	12	uses	use	NOUN
ijpds-4738	174	13	[	[	X
ijpds-4738	174	14	27	27	NUM
ijpds-4738	174	15	,	,	PUNCT
ijpds-4738	174	16	28	28	NUM
ijpds-4738	174	17	]	]	PUNCT
ijpds-4738	174	18	.	.	PUNCT
ijpds-4738	175	1	validation	validation	NOUN
ijpds-4738	175	2	analyst	analyst	NOUN
ijpds-4738	175	3	interpretation	interpretation	NOUN
ijpds-4738	175	4	is	be	AUX
ijpds-4738	175	5	used	use	VERB
ijpds-4738	175	6	to	to	PART
ijpds-4738	175	7	validate	validate	VERB
ijpds-4738	175	8	methods	method	NOUN
ijpds-4738	175	9	because	because	SCONJ
ijpds-4738	175	10	there	there	PRON
ijpds-4738	175	11	is	be	VERB
ijpds-4738	175	12	no	no	DET
ijpds-4738	175	13	industry	industry	NOUN
ijpds-4738	175	14	standard	standard	NOUN
ijpds-4738	175	15	for	for	ADP
ijpds-4738	175	16	assay	assay	ADJ
ijpds-4738	175	17	validation	validation	NOUN
ijpds-4738	175	18	.	.	PUNCT
ijpds-4738	176	1	industry	industry	NOUN
ijpds-4738	176	2	committees	committee	NOUN
ijpds-4738	176	3	,	,	PUNCT
ijpds-4738	176	4	regulatory	regulatory	ADJ
ijpds-4738	176	5	bodies	body	NOUN
ijpds-4738	176	6	,	,	PUNCT
ijpds-4738	176	7	and	and	CCONJ
ijpds-4738	176	8	the	the	DET
ijpds-4738	176	9	international	international	ADJ
ijpds-4738	176	10	conference	conference	NOUN
ijpds-4738	176	11	on	on	ADP
ijpds-4738	176	12	harmonization	harmonization	NOUN
ijpds-4738	176	13	(	(	PUNCT
ijpds-4738	176	14	ich	ich	NOUN
ijpds-4738	176	15	)	)	PUNCT
ijpds-4738	176	16	of	of	ADP
ijpds-4738	176	17	technical	technical	ADJ
ijpds-4738	176	18	standards	standard	NOUN
ijpds-4738	176	19	for	for	ADP
ijpds-4738	176	20	the	the	DET
ijpds-4738	176	21	registration	registration	NOUN
ijpds-4738	176	22	of	of	ADP
ijpds-4738	176	23	medicines	medicine	NOUN
ijpds-4738	176	24	in	in	ADP
ijpds-4738	176	25	human	human	ADJ
ijpds-4738	176	26	use	use	NOUN
ijpds-4738	176	27	have	have	AUX
ijpds-4738	176	28	all	all	PRON
ijpds-4738	176	29	placed	place	VERB
ijpds-4738	176	30	a	a	DET
ijpds-4738	176	31	great	great	ADJ
ijpds-4738	176	32	deal	deal	NOUN
ijpds-4738	176	33	of	of	ADP
ijpds-4738	176	34	emphasis	emphasis	NOUN
ijpds-4738	176	35	on	on	ADP
ijpds-4738	176	36	method	method	NOUN
ijpds-4738	176	37	validation	validation	NOUN
ijpds-4738	176	38	.	.	PUNCT
ijpds-4738	177	1	methods	method	NOUN
ijpds-4738	177	2	that	that	PRON
ijpds-4738	177	3	have	have	AUX
ijpds-4738	177	4	been	be	AUX
ijpds-4738	177	5	verified	verify	VERB
ijpds-4738	177	6	by	by	ADP
ijpds-4738	177	7	multiple	multiple	ADJ
ijpds-4738	177	8	laboratories	laboratory	NOUN
ijpds-4738	177	9	are	be	AUX
ijpds-4738	177	10	offered	offer	VERB
ijpds-4738	177	11	by	by	ADP
ijpds-4738	177	12	the	the	DET
ijpds-4738	177	13	us	us	PROPN
ijpds-4738	177	14	environmental	environmental	PROPN
ijpds-4738	177	15	protection	protection	PROPN
ijpds-4738	177	16	agency	agency	PROPN
ijpds-4738	177	17	(	(	PUNCT
ijpds-4738	177	18	us	us	PROPN
ijpds-4738	177	19	epa	epa	PROPN
ijpds-4738	177	20	)	)	PUNCT
ijpds-4738	177	21	,	,	PUNCT
ijpds-4738	177	22	the	the	DET
ijpds-4738	177	23	resource	resource	NOUN
ijpds-4738	177	24	conservation	conservation	NOUN
ijpds-4738	177	25	and	and	CCONJ
ijpds-4738	177	26	recovery	recovery	NOUN
ijpds-4738	177	27	act	act	PROPN
ijpds-4738	177	28	(	(	PUNCT
ijpds-4738	177	29	rcra	rcra	PROPN
ijpds-4738	177	30	)	)	PUNCT
ijpds-4738	177	31	,	,	PUNCT
ijpds-4738	177	32	the	the	DET
ijpds-4738	177	33	american	american	PROPN
ijpds-4738	177	34	association	association	PROPN
ijpds-4738	177	35	of	of	ADP
ijpds-4738	177	36	official	official	ADJ
ijpds-4738	177	37	analytical	analytical	ADJ
ijpds-4738	177	38	chemists	chemist	NOUN
ijpds-4738	177	39	(	(	PUNCT
ijpds-4738	177	40	aoac	aoac	ADJ
ijpds-4738	177	41	)	)	PUNCT
ijpds-4738	177	42	,	,	PUNCT
ijpds-4738	177	43	the	the	DET
ijpds-4738	177	44	us	us	PROPN
ijpds-4738	177	45	environmental	environmental	PROPN
ijpds-4738	177	46	protection	protection	PROPN
ijpds-4738	177	47	agency	agency	PROPN
ijpds-4738	177	48	(	(	PUNCT
ijpds-4738	177	49	usp	usp	NOUN
ijpds-4738	177	50	)	)	PUNCT
ijpds-4738	177	51	,	,	PUNCT
ijpds-4738	177	52	and	and	CCONJ
ijpds-4738	177	53	other	other	ADJ
ijpds-4738	177	54	scientific	scientific	ADJ
ijpds-4738	177	55	associations	association	NOUN
ijpds-4738	177	56	[	[	X
ijpds-4738	177	57	29	29	NUM
ijpds-4738	177	58	]	]	PUNCT
ijpds-4738	177	59	.	.	PUNCT
ijpds-4738	178	1	the	the	DET
ijpds-4738	178	2	food	food	NOUN
ijpds-4738	178	3	and	and	CCONJ
ijpds-4738	178	4	drug	drug	PROPN
ijpds-4738	178	5	administration	administration	NOUN
ijpds-4738	178	6	(	(	PUNCT
ijpds-4738	178	7	us	us	PROPN
ijpds-4738	178	8	fda	fda	PROPN
ijpds-4738	178	9	)	)	PUNCT
ijpds-4738	178	10	has	have	AUX
ijpds-4738	178	11	put	put	VERB
ijpds-4738	178	12	forward	forward	ADP
ijpds-4738	178	13	criteria	criterion	NOUN
ijpds-4738	178	14	on	on	ADP
ijpds-4738	178	15	the	the	DET
ijpds-4738	178	16	submission	submission	NOUN
ijpds-4738	178	17	of	of	ADP
ijpds-4738	178	18	analytical	analytical	ADJ
ijpds-4738	178	19	and	and	CCONJ
ijpds-4738	178	20	sample	sample	NOUN
ijpds-4738	178	21	data	datum	NOUN
ijpds-4738	178	22	for	for	ADP
ijpds-4738	178	23	the	the	DET
ijpds-4738	178	24	purpose	purpose	NOUN
ijpds-4738	178	25	of	of	ADP
ijpds-4738	178	26	technique	technique	NOUN
ijpds-4738	178	27	validation	validation	NOUN
ijpds-4738	178	28	.	.	PUNCT
ijpds-4738	179	1	particular	particular	ADJ
ijpds-4738	179	2	criteria	criterion	NOUN
ijpds-4738	179	3	have	have	AUX
ijpds-4738	179	4	been	be	AUX
ijpds-4738	179	5	established	establish	VERB
ijpds-4738	179	6	by	by	ADP
ijpds-4738	179	7	the	the	DET
ijpds-4738	179	8	united	united	PROPN
ijpds-4738	179	9	states	states	PROPN
ijpds-4738	179	10	pharmacopoeia	pharmacopoeia	PROPN
ijpds-4738	179	11	(	(	PUNCT
ijpds-4738	179	12	usp	usp	PROPN
ijpds-4738	179	13	)	)	PUNCT
ijpds-4738	179	14	for	for	ADP
ijpds-4738	179	15	technique	technique	NOUN
ijpds-4738	179	16	validation	validation	NOUN
ijpds-4738	179	17	and	and	CCONJ
ijpds-4738	179	18	substance	substance	NOUN
ijpds-4738	179	19	assessment	assessment	NOUN
ijpds-4738	179	20	[	[	X
ijpds-4738	179	21	30	30	NUM
ijpds-4738	179	22	]	]	PUNCT
ijpds-4738	179	23	.	.	PUNCT
ijpds-4738	180	1	the	the	DET
ijpds-4738	180	2	four	four	NUM
ijpds-4738	180	3	most	most	ADV
ijpds-4738	180	4	prevalent	prevalent	ADJ
ijpds-4738	180	5	types	type	NOUN
ijpds-4738	180	6	of	of	ADP
ijpds-4738	180	7	analytical	analytical	ADJ
ijpds-4738	180	8	processes	process	NOUN
ijpds-4738	180	9	are	be	AUX
ijpds-4738	180	10	the	the	DET
ijpds-4738	180	11	focus	focus	NOUN
ijpds-4738	180	12	of	of	ADP
ijpds-4738	180	13	the	the	DET
ijpds-4738	180	14	debate	debate	NOUN
ijpds-4738	180	15	on	on	ADP
ijpds-4738	180	16	their	their	PRON
ijpds-4738	180	17	validity	validity	NOUN
ijpds-4738	180	18	.	.	PUNCT
ijpds-4738	181	1	1	1	X
ijpds-4738	181	2	.	.	X
ijpds-4738	181	3	tests	test	NOUN
ijpds-4738	181	4	for	for	ADP
ijpds-4738	181	5	identification	identification	NOUN
ijpds-4738	181	6	.	.	PUNCT
ijpds-4738	182	1	2	2	X
ijpds-4738	182	2	.	.	NUM
ijpds-4738	182	3	measurements	measurement	NOUN
ijpds-4738	182	4	that	that	PRON
ijpds-4738	182	5	quantify	quantify	VERB
ijpds-4738	182	6	the	the	DET
ijpds-4738	182	7	amount	amount	NOUN
ijpds-4738	182	8	of	of	ADP
ijpds-4738	182	9	contaminants	contaminant	NOUN
ijpds-4738	182	10	.	.	PUNCT
ijpds-4738	183	1	3	3	X
ijpds-4738	183	2	.	.	X
ijpds-4738	183	3	limit	limit	NOUN
ijpds-4738	183	4	assessments	assessment	NOUN
ijpds-4738	183	5	for	for	ADP
ijpds-4738	183	6	impurity	impurity	NOUN
ijpds-4738	183	7	control	control	NOUN
ijpds-4738	183	8	.	.	PUNCT
ijpds-4738	184	1	4	4	X
ijpds-4738	184	2	.	.	X
ijpds-4738	184	3	quantitative	quantitative	ADJ
ijpds-4738	184	4	analyses	analysis	NOUN
ijpds-4738	184	5	of	of	ADP
ijpds-4738	184	6	the	the	DET
ijpds-4738	184	7	active	active	ADJ
ijpds-4738	184	8	ingredient	ingredient	NOUN
ijpds-4738	184	9	in	in	ADP
ijpds-4738	184	10	drug	drug	NOUN
ijpds-4738	184	11	substance	substance	NOUN
ijpds-4738	184	12	or	or	CCONJ
ijpds-4738	184	13	product	product	NOUN
ijpds-4738	184	14	samples	sample	NOUN
ijpds-4738	184	15	,	,	PUNCT
ijpds-4738	184	16	as	as	ADV
ijpds-4738	184	17	well	well	ADV
ijpds-4738	184	18	as	as	ADP
ijpds-4738	184	19	other	other	ADJ
ijpds-4738	184	20	specific	specific	ADJ
ijpds-4738	184	21	components	component	NOUN
ijpds-4738	184	22	within	within	ADP
ijpds-4738	184	23	the	the	DET
ijpds-4738	184	24	drug	drug	NOUN
ijpds-4738	184	25	product	product	NOUN
ijpds-4738	184	26	[	[	X
ijpds-4738	184	27	31	31	NUM
ijpds-4738	184	28	]	]	PUNCT
ijpds-4738	184	29	.	.	PUNCT
ijpds-4738	185	1	various	various	ADJ
ijpds-4738	185	2	need	need	NOUN
ijpds-4738	185	3	to	to	PART
ijpds-4738	185	4	be	be	AUX
ijpds-4738	185	5	validated	validate	VERB
ijpds-4738	185	6	.	.	PUNCT
ijpds-4738	186	1	1	1	X
ijpds-4738	186	2	.	.	X
ijpds-4738	187	1	whenever	whenever	SCONJ
ijpds-4738	187	2	the	the	DET
ijpds-4738	187	3	condition	condition	NOUN
ijpds-4738	187	4	for	for	ADP
ijpds-4738	187	5	which	which	PRON
ijpds-4738	187	6	the	the	DET
ijpds-4738	187	7	technique	technique	NOUN
ijpds-4738	187	8	has	have	AUX
ijpds-4738	187	9	been	be	AUX
ijpds-4738	187	10	validated	validate	VERB
ijpds-4738	187	11	changes	change	NOUN
ijpds-4738	187	12	,	,	PUNCT
ijpds-4738	187	13	such	such	ADJ
ijpds-4738	187	14	as	as	ADP
ijpds-4738	187	15	an	an	DET
ijpds-4738	187	16	instrument	instrument	NOUN
ijpds-4738	187	17	with	with	ADP
ijpds-4738	187	18	new	new	ADJ
ijpds-4738	187	19	features	feature	NOUN
ijpds-4738	187	20	,	,	PUNCT
ijpds-4738	187	21	prior	prior	ADV
ijpds-4738	187	22	to	to	ADP
ijpds-4738	187	23	its	its	PRON
ijpds-4738	187	24	introduction	introduction	NOUN
ijpds-4738	187	25	into	into	ADP
ijpds-4738	187	26	regular	regular	ADJ
ijpds-4738	187	27	usage	usage	NOUN
ijpds-4738	187	28	.	.	PUNCT
ijpds-4738	188	1	2	2	X
ijpds-4738	188	2	.	.	X
ijpds-4738	188	3	whenever	whenever	SCONJ
ijpds-4738	188	4	modifications	modification	NOUN
ijpds-4738	188	5	are	be	AUX
ijpds-4738	188	6	made	make	VERB
ijpds-4738	188	7	to	to	ADP
ijpds-4738	188	8	the	the	DET
ijpds-4738	188	9	procedure	procedure	NOUN
ijpds-4738	188	10	that	that	PRON
ijpds-4738	188	11	go	go	VERB
ijpds-4738	188	12	beyond	beyond	ADP
ijpds-4738	188	13	its	its	PRON
ijpds-4738	188	14	initial	initial	ADJ
ijpds-4738	188	15	parameters	parameter	NOUN
ijpds-4738	188	16	[	[	X
ijpds-4738	188	17	32	32	NUM
ijpds-4738	188	18	]	]	PUNCT
ijpds-4738	188	19	.	.	PUNCT
ijpds-4738	189	1	various	various	ADJ
ijpds-4738	189	2	parameters	parameter	NOUN
ijpds-4738	189	3	are	be	AUX
ijpds-4738	189	4	given	give	VERB
ijpds-4738	189	5	below	below	ADP
ijpds-4738	189	6	:	:	PUNCT
ijpds-4738	189	7	a	a	X
ijpds-4738	189	8	)	)	PUNCT
ijpds-4738	189	9	accuracy	accuracy	NOUN
ijpds-4738	189	10	accuracy	accuracy	NOUN
ijpds-4738	189	11	is	be	AUX
ijpds-4738	189	12	the	the	DET
ijpds-4738	189	13	level	level	NOUN
ijpds-4738	189	14	to	to	PART
ijpds-4738	189	15	which	which	PRON
ijpds-4738	189	16	the	the	DET
ijpds-4738	189	17	value	value	NOUN
ijpds-4738	189	18	being	be	AUX
ijpds-4738	189	19	measured	measure	VERB
ijpds-4738	189	20	agrees	agree	VERB
ijpds-4738	189	21	with	with	ADP
ijpds-4738	189	22	the	the	DET
ijpds-4738	189	23	true	true	ADJ
ijpds-4738	189	24	or	or	CCONJ
ijpds-4738	189	25	recognized	recognize	VERB
ijpds-4738	189	26	value	value	NOUN
ijpds-4738	189	27	.	.	PUNCT
ijpds-4738	190	1	in	in	ADP
ijpds-4738	190	2	practical	practical	ADJ
ijpds-4738	190	3	terms	term	NOUN
ijpds-4738	190	4	,	,	PUNCT
ijpds-4738	190	5	accuracy	accuracy	NOUN
ijpds-4738	190	6	is	be	AUX
ijpds-4738	190	7	the	the	DET
ijpds-4738	190	8	discrepancy	discrepancy	NOUN
ijpds-4738	190	9	between	between	ADP
ijpds-4738	190	10	the	the	DET
ijpds-4738	190	11	actual	actual	ADJ
ijpds-4738	190	12	value	value	NOUN
ijpds-4738	190	13	and	and	CCONJ
ijpds-4738	190	14	the	the	DET
ijpds-4738	190	15	mean	mean	ADJ
ijpds-4738	190	16	value	value	NOUN
ijpds-4738	190	17	that	that	PRON
ijpds-4738	190	18	was	be	AUX
ijpds-4738	190	19	produced	produce	VERB
ijpds-4738	190	20	.	.	PUNCT
ijpds-4738	191	1	to	to	PART
ijpds-4738	191	2	ascertain	ascertain	VERB
ijpds-4738	191	3	accuracy	accuracy	NOUN
ijpds-4738	191	4	,	,	PUNCT
ijpds-4738	191	5	the	the	DET
ijpds-4738	191	6	process	process	NOUN
ijpds-4738	191	7	is	be	AUX
ijpds-4738	191	8	applied	apply	VERB
ijpds-4738	191	9	to	to	ADP
ijpds-4738	191	10	samples	sample	NOUN
ijpds-4738	191	11	with	with	ADP
ijpds-4738	191	12	known	known	ADJ
ijpds-4738	191	13	analyte	analyte	NOUN
ijpds-4738	191	14	concentrations	concentration	NOUN
ijpds-4738	191	15	.	.	PUNCT
ijpds-4738	192	1	accuracy	accuracy	NOUN
ijpds-4738	192	2	is	be	AUX
ijpds-4738	192	3	computed	compute	VERB
ijpds-4738	192	4	as	as	ADP
ijpds-4738	192	5	a	a	DET
ijpds-4738	192	6	share	share	NOUN
ijpds-4738	192	7	of	of	ADP
ijpds-4738	192	8	the	the	DET
ijpds-4738	192	9	analyser	analyser	NOUN
ijpds-4738	192	10	retrieved	retrieve	VERB
ijpds-4738	192	11	by	by	ADP
ijpds-4738	192	12	the	the	DET
ijpds-4738	192	13	assay	assay	NOUN
ijpds-4738	192	14	based	base	VERB
ijpds-4738	192	15	on	on	ADP
ijpds-4738	192	16	test	test	NOUN
ijpds-4738	192	17	results	result	NOUN
ijpds-4738	192	18	.	.	PUNCT
ijpds-4738	193	1	it	it	PRON
ijpds-4738	193	2	is	be	AUX
ijpds-4738	193	3	commonly	commonly	ADV
ijpds-4738	193	4	expressed	express	VERB
ijpds-4738	193	5	as	as	ADP
ijpds-4738	193	6	the	the	DET
ijpds-4738	193	7	assay	assay	NOUN
ijpds-4738	193	8	-	-	PUNCT
ijpds-4738	193	9	based	base	VERB
ijpds-4738	193	10	recovery	recovery	NOUN
ijpds-4738	193	11	of	of	ADP
ijpds-4738	193	12	the	the	DET
ijpds-4738	193	13	additional	additional	ADJ
ijpds-4738	193	14	analyte	analyte	NOUN
ijpds-4738	193	15	levels	level	NOUN
ijpds-4738	193	16	that	that	PRON
ijpds-4738	193	17	are	be	AUX
ijpds-4738	193	18	known	know	VERB
ijpds-4738	193	19	;	;	PUNCT
ijpds-4738	193	20	this	this	PRON
ijpds-4738	193	21	indicates	indicate	VERB
ijpds-4738	193	22	the	the	DET
ijpds-4738	193	23	degree	degree	NOUN
ijpds-4738	193	24	to	to	PART
ijpds-4738	193	25	which	which	PRON
ijpds-4738	193	26	the	the	DET
ijpds-4738	193	27	real	real	ADJ
ijpds-4738	193	28	values	value	NOUN
ijpds-4738	193	29	are	be	AUX
ijpds-4738	193	30	captured	capture	VERB
ijpds-4738	193	31	by	by	ADP
ijpds-4738	193	32	the	the	DET
ijpds-4738	193	33	analytical	analytical	ADJ
ijpds-4738	193	34	method	method	NOUN
ijpds-4738	193	35	[	[	X
ijpds-4738	193	36	33	33	NUM
ijpds-4738	193	37	,	,	PUNCT
ijpds-4738	193	38	34	34	NUM
ijpds-4738	193	39	]	]	PUNCT
ijpds-4738	193	40	.	.	PUNCT
ijpds-4738	194	1	b	b	X
ijpds-4738	194	2	)	)	PUNCT
ijpds-4738	194	3	precision	precision	NOUN
ijpds-4738	194	4	in	in	ADP
ijpds-4738	194	5	analytical	analytical	ADJ
ijpds-4738	194	6	procedures	procedure	NOUN
ijpds-4738	194	7	,	,	PUNCT
ijpds-4738	194	8	precision	precision	NOUN
ijpds-4738	194	9	is	be	AUX
ijpds-4738	194	10	associated	associate	VERB
ijpds-4738	194	11	with	with	ADP
ijpds-4738	194	12	the	the	DET
ijpds-4738	194	13	degree	degree	NOUN
ijpds-4738	194	14	of	of	ADP
ijpds-4738	194	15	agreement	agreement	NOUN
ijpds-4738	194	16	and	and	CCONJ
ijpds-4738	194	17	dispersion	dispersion	NOUN
ijpds-4738	194	18	between	between	ADP
ijpds-4738	194	19	several	several	ADJ
ijpds-4738	194	20	measurements	measurement	NOUN
ijpds-4738	194	21	taken	take	VERB
ijpds-4738	194	22	under	under	ADP
ijpds-4738	194	23	particular	particular	ADJ
ijpds-4738	194	24	circumstances	circumstance	NOUN
ijpds-4738	194	25	from	from	ADP
ijpds-4738	194	26	different	different	ADJ
ijpds-4738	194	27	samples	sample	NOUN
ijpds-4738	194	28	of	of	ADP
ijpds-4738	194	29	the	the	DET
ijpds-4738	194	30	same	same	ADJ
ijpds-4738	194	31	homogenous	homogenous	ADJ
ijpds-4738	194	32	material	material	NOUN
ijpds-4738	194	33	.	.	PUNCT
ijpds-4738	195	1	a	a	DET
ijpds-4738	195	2	crucial	crucial	ADJ
ijpds-4738	195	3	factor	factor	NOUN
ijpds-4738	195	4	in	in	ADP
ijpds-4738	195	5	determining	determine	VERB
ijpds-4738	195	6	the	the	DET
ijpds-4738	195	7	repeatability	repeatability	NOUN
ijpds-4738	195	8	of	of	ADP
ijpds-4738	195	9	the	the	DET
ijpds-4738	195	10	entire	entire	ADJ
ijpds-4738	195	11	analytical	analytical	ADJ
ijpds-4738	195	12	process	process	NOUN
ijpds-4738	195	13	is	be	AUX
ijpds-4738	195	14	precision	precision	NOUN
ijpds-4738	195	15	.	.	PUNCT
ijpds-4738	196	1	precision	precision	NOUN
ijpds-4738	196	2	consists	consist	VERB
ijpds-4738	196	3	of	of	ADP
ijpds-4738	196	4	two	two	NUM
ijpds-4738	196	5	elements	element	NOUN
ijpds-4738	196	6	:	:	PUNCT
ijpds-4738	196	7	intermediate	intermediate	ADJ
ijpds-4738	196	8	precision	precision	NOUN
ijpds-4738	196	9	and	and	CCONJ
ijpds-4738	196	10	repeatability	repeatability	NOUN
ijpds-4738	196	11	.	.	PUNCT
ijpds-4738	197	1	repeatability	repeatability	NOUN
ijpds-4738	197	2	is	be	AUX
ijpds-4738	197	3	the	the	DET
ijpds-4738	197	4	difference	difference	NOUN
ijpds-4738	197	5	between	between	ADP
ijpds-4738	197	6	two	two	NUM
ijpds-4738	197	7	measurements	measurement	NOUN
ijpds-4738	197	8	made	make	VERB
ijpds-4738	197	9	by	by	ADP
ijpds-4738	197	10	one	one	NUM
ijpds-4738	197	11	analyst	analyst	NOUN
ijpds-4738	197	12	using	use	VERB
ijpds-4738	197	13	the	the	DET
ijpds-4738	197	14	same	same	ADJ
ijpds-4738	197	15	tool	tool	NOUN
ijpds-4738	197	16	these	these	DET
ijpds-4738	197	17	precision	precision	NOUN
ijpds-4738	197	18	assessment	assessment	NOUN
ijpds-4738	197	19	components	component	NOUN
ijpds-4738	197	20	guarantee	guarantee	VERB
ijpds-4738	197	21	a	a	DET
ijpds-4738	197	22	thorough	thorough	ADJ
ijpds-4738	197	23	comprehension	comprehension	NOUN
ijpds-4738	197	24	of	of	ADP
ijpds-4738	197	25	the	the	DET
ijpds-4738	197	26	analytical	analytical	ADJ
ijpds-4738	197	27	method	method	NOUN
ijpds-4738	197	28	's	's	PART
ijpds-4738	197	29	repeatability	repeatability	NOUN
ijpds-4738	197	30	and	and	CCONJ
ijpds-4738	197	31	dependability	dependability	NOUN
ijpds-4738	197	32	across	across	ADP
ijpds-4738	197	33	various	various	ADJ
ijpds-4738	197	34	operators	operator	NOUN
ijpds-4738	197	35	and	and	CCONJ
ijpds-4738	197	36	settings	setting	NOUN
ijpds-4738	197	37	[	[	X
ijpds-4738	197	38	35	35	NUM
ijpds-4738	197	39	,	,	PUNCT
ijpds-4738	197	40	36	36	NUM
ijpds-4738	197	41	]	]	PUNCT
ijpds-4738	197	42	.	.	PUNCT
ijpds-4738	198	1	%	%	X
ijpds-4738	198	2	rsd	rsd	NOUN
ijpds-4738	198	3	=	=	NOUN
ijpds-4738	198	4	std	std	NOUN
ijpds-4738	198	5	dev.*100	dev.*100	NOUN
ijpds-4738	198	6	/	/	SYM
ijpds-4738	198	7	mean	mean	NOUN
ijpds-4738	198	8	c	c	NOUN
ijpds-4738	198	9	)	)	PUNCT
ijpds-4738	198	10	linearity	linearity	NOUN
ijpds-4738	198	11	patil	patil	PROPN
ijpds-4738	198	12	et	et	PROPN
ijpds-4738	198	13	al	al	PROPN
ijpds-4738	198	14	.	.	PROPN
ijpds-4738	199	1	analytical	analytical	ADJ
ijpds-4738	199	2	method	method	PROPN
ijpds-4738	199	3	development	development	NOUN
ijpds-4738	199	4	and	and	CCONJ
ijpds-4738	199	5	validation	validation	NOUN
ijpds-4738	199	6	online	online	ADJ
ijpds-4738	199	7	first	first	PROPN
ijpds-4738	199	8	indian	indian	PROPN
ijpds-4738	199	9	j	j	PROPN
ijpds-4738	199	10	pharm	pharm	PROPN
ijpds-4738	199	11	drug	drug	PROPN
ijpds-4738	199	12	studies	study	NOUN
ijpds-4738	199	13	|	|	ADV
ijpds-4738	199	14	5	5	NUM
ijpds-4738	199	15	a	a	DET
ijpds-4738	199	16	technique	technique	NOUN
ijpds-4738	199	17	for	for	ADP
ijpds-4738	199	18	analysis	analysis	NOUN
ijpds-4738	199	19	is	be	AUX
ijpds-4738	199	20	said	say	VERB
ijpds-4738	199	21	to	to	PART
ijpds-4738	199	22	be	be	AUX
ijpds-4738	199	23	linear	linear	ADJ
ijpds-4738	199	24	if	if	SCONJ
ijpds-4738	199	25	it	it	PRON
ijpds-4738	199	26	can	can	AUX
ijpds-4738	199	27	yield	yield	VERB
ijpds-4738	199	28	test	test	NOUN
ijpds-4738	199	29	results	result	NOUN
ijpds-4738	199	30	that	that	PRON
ijpds-4738	199	31	are	be	AUX
ijpds-4738	199	32	precisely	precisely	ADV
ijpds-4738	199	33	matched	match	VERB
ijpds-4738	199	34	to	to	ADP
ijpds-4738	199	35	the	the	DET
ijpds-4738	199	36	concentration	concentration	NOUN
ijpds-4738	199	37	of	of	ADP
ijpds-4738	199	38	any	any	DET
ijpds-4738	199	39	analyte	analyte	NOUN
ijpds-4738	199	40	in	in	ADP
ijpds-4738	199	41	the	the	DET
ijpds-4738	199	42	sample	sample	NOUN
ijpds-4738	199	43	.	.	PUNCT
ijpds-4738	200	1	one	one	NUM
ijpds-4738	200	2	way	way	NOUN
ijpds-4738	200	3	to	to	PART
ijpds-4738	200	4	demonstrate	demonstrate	VERB
ijpds-4738	200	5	linearity	linearity	NOUN
ijpds-4738	200	6	on	on	ADP
ijpds-4738	200	7	the	the	DET
ijpds-4738	200	8	test	test	NOUN
ijpds-4738	200	9	material	material	NOUN
ijpds-4738	200	10	is	be	AUX
ijpds-4738	200	11	to	to	PART
ijpds-4738	200	12	dilute	dilute	VERB
ijpds-4738	200	13	a	a	DET
ijpds-4738	200	14	standard	standard	ADJ
ijpds-4738	200	15	stock	stock	NOUN
ijpds-4738	200	16	solution	solution	NOUN
ijpds-4738	200	17	,	,	PUNCT
ijpds-4738	200	18	or	or	CCONJ
ijpds-4738	200	19	another	another	DET
ijpds-4738	200	20	method	method	NOUN
ijpds-4738	200	21	is	be	AUX
ijpds-4738	200	22	to	to	PART
ijpds-4738	200	23	weigh	weigh	VERB
ijpds-4738	200	24	each	each	DET
ijpds-4738	200	25	component	component	NOUN
ijpds-4738	200	26	separately	separately	ADV
ijpds-4738	200	27	in	in	ADP
ijpds-4738	200	28	synthetic	synthetic	ADJ
ijpds-4738	200	29	blends	blend	NOUN
ijpds-4738	200	30	of	of	ADP
ijpds-4738	200	31	the	the	DET
ijpds-4738	200	32	test	test	NOUN
ijpds-4738	200	33	product	product	NOUN
ijpds-4738	200	34	.	.	PUNCT
ijpds-4738	201	1	the	the	DET
ijpds-4738	201	2	linearity	linearity	NOUN
ijpds-4738	201	3	is	be	AUX
ijpds-4738	201	4	confirmed	confirm	VERB
ijpds-4738	201	5	via	via	ADP
ijpds-4738	201	6	injecting	inject	VERB
ijpds-4738	201	7	five	five	NUM
ijpds-4738	201	8	to	to	PART
ijpds-4738	201	9	six	six	NUM
ijpds-4738	201	10	times	time	NOUN
ijpds-4738	201	11	at	at	ADP
ijpds-4738	201	12	least	least	ADJ
ijpds-4738	201	13	five	five	NUM
ijpds-4738	201	14	standards	standard	NOUN
ijpds-4738	201	15	at	at	ADP
ijpds-4738	201	16	doses	dose	NOUN
ijpds-4738	201	17	between	between	ADP
ijpds-4738	201	18	80	80	NUM
ijpds-4738	201	19	and	and	CCONJ
ijpds-4738	201	20	120	120	NUM
ijpds-4738	201	21	percent	percent	NOUN
ijpds-4738	201	22	of	of	ADP
ijpds-4738	201	23	the	the	DET
ijpds-4738	201	24	estimated	estimate	VERB
ijpds-4738	201	25	concentration	concentration	NOUN
ijpds-4738	201	26	range	range	NOUN
ijpds-4738	201	27	.	.	PUNCT
ijpds-4738	202	1	a	a	DET
ijpds-4738	202	2	precise	precise	ADJ
ijpds-4738	202	3	mathematical	mathematical	ADJ
ijpds-4738	202	4	computation	computation	NOUN
ijpds-4738	202	5	must	must	AUX
ijpds-4738	202	6	determine	determine	VERB
ijpds-4738	202	7	the	the	DET
ijpds-4738	202	8	proportionality	proportionality	NOUN
ijpds-4738	202	9	of	of	ADP
ijpds-4738	202	10	the	the	DET
ijpds-4738	202	11	reaction	reaction	NOUN
ijpds-4738	202	12	,	,	PUNCT
ijpds-4738	202	13	or	or	CCONJ
ijpds-4738	202	14	it	it	PRON
ijpds-4738	202	15	must	must	AUX
ijpds-4738	202	16	be	be	AUX
ijpds-4738	202	17	proportional	proportional	ADJ
ijpds-4738	202	18	right	right	ADV
ijpds-4738	202	19	away	away	ADV
ijpds-4738	202	20	to	to	ADP
ijpds-4738	202	21	the	the	DET
ijpds-4738	202	22	analyte	analyte	NOUN
ijpds-4738	202	23	concentrations	concentration	NOUN
ijpds-4738	202	24	.	.	PUNCT
ijpds-4738	203	1	d	d	X
ijpds-4738	203	2	)	)	PUNCT
ijpds-4738	203	3	limit	limit	NOUN
ijpds-4738	203	4	of	of	ADP
ijpds-4738	203	5	detection	detection	NOUN
ijpds-4738	203	6	[	[	X
ijpds-4738	203	7	loc	loc	X
ijpds-4738	203	8	]	]	X
ijpds-4738	203	9	analysing	analyse	VERB
ijpds-4738	203	10	an	an	DET
ijpds-4738	203	11	analyte	analyte	NOUN
ijpds-4738	203	12	's	's	PART
ijpds-4738	203	13	threshold	threshold	NOUN
ijpds-4738	203	14	for	for	ADP
ijpds-4738	203	15	detection	detection	NOUN
ijpds-4738	203	16	using	use	VERB
ijpds-4738	203	17	a	a	DET
ijpds-4738	203	18	single	single	ADJ
ijpds-4738	203	19	method	method	NOUN
ijpds-4738	203	20	is	be	AUX
ijpds-4738	203	21	the	the	DET
ijpds-4738	203	22	easiest	easy	ADJ
ijpds-4738	203	23	approach	approach	NOUN
ijpds-4738	203	24	to	to	ADP
ijpds-4738	203	25	quantifying	quantify	VERB
ijpds-4738	203	26	it	it	PRON
ijpds-4738	203	27	in	in	ADP
ijpds-4738	203	28	a	a	DET
ijpds-4738	203	29	sample	sample	NOUN
ijpds-4738	203	30	when	when	SCONJ
ijpds-4738	203	31	it	it	PRON
ijpds-4738	203	32	can	can	AUX
ijpds-4738	203	33	be	be	AUX
ijpds-4738	203	34	identified	identify	VERB
ijpds-4738	203	35	but	but	CCONJ
ijpds-4738	203	36	not	not	PART
ijpds-4738	203	37	accurately	accurately	ADV
ijpds-4738	203	38	measured	measure	VERB
ijpds-4738	203	39	.	.	PUNCT
ijpds-4738	204	1	is	be	AUX
ijpds-4738	204	2	typically	typically	ADV
ijpds-4738	204	3	used	use	VERB
ijpds-4738	204	4	to	to	PART
ijpds-4738	204	5	express	express	VERB
ijpds-4738	204	6	the	the	DET
ijpds-4738	204	7	lod	lod	PROPN
ijpds-4738	204	8	.	.	PUNCT
ijpds-4738	205	1	determination	determination	NOUN
ijpds-4738	205	2	:	:	PUNCT
ijpds-4738	205	3	for	for	ADP
ijpds-4738	205	4	noninstrumental	noninstrumental	ADJ
ijpds-4738	205	5	approaches	approach	NOUN
ijpds-4738	205	6	,	,	PUNCT
ijpds-4738	205	7	the	the	DET
ijpds-4738	205	8	lowest	low	ADJ
ijpds-4738	205	9	level	level	NOUN
ijpds-4738	205	10	at	at	ADP
ijpds-4738	205	11	which	which	PRON
ijpds-4738	205	12	the	the	DET
ijpds-4738	205	13	analyte	analyte	NOUN
ijpds-4738	205	14	may	may	AUX
ijpds-4738	205	15	be	be	AUX
ijpds-4738	205	16	reliably	reliably	ADV
ijpds-4738	205	17	detected	detect	VERB
ijpds-4738	205	18	is	be	AUX
ijpds-4738	205	19	established	establish	VERB
ijpds-4738	205	20	,	,	PUNCT
ijpds-4738	205	21	and	and	CCONJ
ijpds-4738	205	22	samples	sample	NOUN
ijpds-4738	205	23	with	with	ADP
ijpds-4738	205	24	known	known	ADJ
ijpds-4738	205	25	concentrations	concentration	NOUN
ijpds-4738	205	26	of	of	ADP
ijpds-4738	205	27	the	the	DET
ijpds-4738	205	28	analyte	analyte	NOUN
ijpds-4738	205	29	are	be	AUX
ijpds-4738	205	30	analysed	analyse	VERB
ijpds-4738	205	31	to	to	PART
ijpds-4738	205	32	determine	determine	VERB
ijpds-4738	205	33	the	the	DET
ijpds-4738	205	34	detection	detection	NOUN
ijpds-4738	205	35	limit	limit	NOUN
ijpds-4738	205	36	.	.	PUNCT
ijpds-4738	206	1	ich	ich	NOUN
ijpds-4738	206	2	standards	standard	NOUN
ijpds-4738	206	3	:	:	PUNCT
ijpds-4738	206	4	the	the	DET
ijpds-4738	206	5	ich	ich	NOUN
ijpds-4738	206	6	outlines	outline	VERB
ijpds-4738	206	7	a	a	DET
ijpds-4738	206	8	standard	standard	ADJ
ijpds-4738	206	9	procedure	procedure	NOUN
ijpds-4738	206	10	that	that	PRON
ijpds-4738	206	11	involves	involve	VERB
ijpds-4738	206	12	comparing	compare	VERB
ijpds-4738	206	13	the	the	DET
ijpds-4738	206	14	observed	observe	VERB
ijpds-4738	206	15	signal	signal	NOUN
ijpds-4738	206	16	between	between	ADP
ijpds-4738	206	17	samples	sample	NOUN
ijpds-4738	206	18	that	that	PRON
ijpds-4738	206	19	have	have	AUX
ijpds-4738	206	20	known	know	VERB
ijpds-4738	206	21	analyte	analyte	NOUN
ijpds-4738	206	22	concentrations	concentration	NOUN
ijpds-4738	206	23	and	and	CCONJ
ijpds-4738	206	24	those	those	PRON
ijpds-4738	206	25	that	that	PRON
ijpds-4738	206	26	are	be	AUX
ijpds-4738	206	27	blank	blank	ADJ
ijpds-4738	206	28	.	.	PUNCT
ijpds-4738	207	1	it	it	PRON
ijpds-4738	207	2	is	be	AUX
ijpds-4738	207	3	determined	determine	VERB
ijpds-4738	207	4	what	what	PRON
ijpds-4738	207	5	the	the	DET
ijpds-4738	207	6	analyte	analyte	NOUN
ijpds-4738	207	7	's	's	PART
ijpds-4738	207	8	minimal	minimal	ADJ
ijpds-4738	207	9	concentration	concentration	NOUN
ijpds-4738	207	10	is	be	AUX
ijpds-4738	207	11	at	at	ADP
ijpds-4738	207	12	which	which	PRON
ijpds-4738	207	13	it	it	PRON
ijpds-4738	207	14	may	may	AUX
ijpds-4738	207	15	be	be	AUX
ijpds-4738	207	16	accurately	accurately	ADV
ijpds-4738	207	17	identified	identify	VERB
ijpds-4738	207	18	.	.	PUNCT
ijpds-4738	208	1	lod	lod	PROPN
ijpds-4738	208	2	computations	computation	NOUN
ijpds-4738	208	3	pertaining	pertain	VERB
ijpds-4738	208	4	to	to	AUX
ijpds-4738	208	5	instrument	instrument	VERB
ijpds-4738	208	6	sensitivity	sensitivity	NOUN
ijpds-4738	208	7	lod(mg	lod(mg	NOUN
ijpds-4738	208	8	/	/	SYM
ijpds-4738	208	9	l)=3×noise	l)=3×noise	NOUN
ijpds-4738	208	10	/	/	SYM
ijpds-4738	208	11	signal	signal	NOUN
ijpds-4738	208	12	the	the	DET
ijpds-4738	208	13	linearity	linearity	NOUN
ijpds-4738	208	14	samples	sample	NOUN
ijpds-4738	208	15	'	'	PART
ijpds-4738	208	16	lowest	low	ADJ
ijpds-4738	208	17	concentration	concentration	NOUN
ijpds-4738	208	18	a	a	DET
ijpds-4738	208	19	2:1	2:1	NUM
ijpds-4738	208	20	or	or	CCONJ
ijpds-4738	208	21	3:1	3:1	NUM
ijpds-4738	208	22	signal	signal	NOUN
ijpds-4738	208	23	-	-	PUNCT
ijpds-4738	208	24	to	to	ADP
ijpds-4738	208	25	-	-	PUNCT
ijpds-4738	208	26	noise	noise	NOUN
ijpds-4738	208	27	ratio	ratio	NOUN
ijpds-4738	208	28	is	be	AUX
ijpds-4738	208	29	often	often	ADV
ijpds-4738	208	30	considered	consider	VERB
ijpds-4738	208	31	adequate	adequate	ADJ
ijpds-4738	208	32	[	[	X
ijpds-4738	208	33	37	37	NUM
ijpds-4738	208	34	,	,	PUNCT
ijpds-4738	208	35	38	38	NUM
ijpds-4738	208	36	,	,	PUNCT
ijpds-4738	208	37	39	39	NUM
ijpds-4738	208	38	]	]	PUNCT
ijpds-4738	208	39	.	.	PUNCT
ijpds-4738	209	1	e	e	X
ijpds-4738	209	2	)	)	PUNCT
ijpds-4738	209	3	limit	limit	NOUN
ijpds-4738	209	4	of	of	ADP
ijpds-4738	209	5	quantification	quantification	NOUN
ijpds-4738	209	6	(	(	PUNCT
ijpds-4738	209	7	loq	loq	PROPN
ijpds-4738	209	8	)	)	PUNCT
ijpds-4738	209	9	minimal	minimal	ADJ
ijpds-4738	209	10	level	level	NOUN
ijpds-4738	209	11	of	of	ADP
ijpds-4738	209	12	analyte	analyte	NOUN
ijpds-4738	209	13	for	for	ADP
ijpds-4738	209	14	the	the	DET
ijpds-4738	209	15	purpose	purpose	NOUN
ijpds-4738	209	16	of	of	ADP
ijpds-4738	209	17	evaluating	evaluate	VERB
ijpds-4738	209	18	low	low	ADJ
ijpds-4738	209	19	analyte	analyte	NOUN
ijpds-4738	209	20	levels	level	NOUN
ijpds-4738	209	21	in	in	ADP
ijpds-4738	209	22	test	test	NOUN
ijpds-4738	209	23	matrices	matrix	NOUN
ijpds-4738	209	24	;	;	PUNCT
ijpds-4738	209	25	this	this	DET
ijpds-4738	209	26	limit	limit	NOUN
ijpds-4738	209	27	functions	function	NOUN
ijpds-4738	209	28	as	as	ADP
ijpds-4738	209	29	a	a	DET
ijpds-4738	209	30	quantitative	quantitative	ADJ
ijpds-4738	209	31	test	test	NOUN
ijpds-4738	209	32	parameter	parameter	NOUN
ijpds-4738	209	33	.	.	PUNCT
ijpds-4738	210	1	the	the	DET
ijpds-4738	210	2	quantitation	quantitation	NOUN
ijpds-4738	210	3	limit	limit	NOUN
ijpds-4738	210	4	serves	serve	VERB
ijpds-4738	210	5	as	as	ADP
ijpds-4738	210	6	a	a	DET
ijpds-4738	210	7	threshold	threshold	NOUN
ijpds-4738	210	8	for	for	ADP
ijpds-4738	210	9	accurate	accurate	ADJ
ijpds-4738	210	10	quantitative	quantitative	ADJ
ijpds-4738	210	11	measurements	measurement	NOUN
ijpds-4738	210	12	on	on	ADP
ijpds-4738	210	13	analytical	analytical	ADJ
ijpds-4738	210	14	procedures	procedure	NOUN
ijpds-4738	210	15	and	and	CCONJ
ijpds-4738	210	16	is	be	AUX
ijpds-4738	210	17	essential	essential	ADJ
ijpds-4738	210	18	for	for	ADP
ijpds-4738	210	19	detecting	detect	VERB
ijpds-4738	210	20	contaminants	contaminant	NOUN
ijpds-4738	210	21	and/or	and/or	CCONJ
ijpds-4738	210	22	impurities	impurity	NOUN
ijpds-4738	210	23	in	in	ADP
ijpds-4738	210	24	samples	sample	NOUN
ijpds-4738	210	25	[	[	X
ijpds-4738	210	26	40	40	NUM
ijpds-4738	210	27	]	]	PUNCT
ijpds-4738	210	28	.	.	PUNCT
ijpds-4738	211	1	a	a	DET
ijpds-4738	211	2	single	single	ADJ
ijpds-4738	211	3	analytical	analytical	ADJ
ijpds-4738	211	4	procedure	procedure	NOUN
ijpds-4738	211	5	's	's	PART
ijpds-4738	211	6	limit	limit	NOUN
ijpds-4738	211	7	of	of	ADP
ijpds-4738	211	8	quantitation	quantitation	NOUN
ijpds-4738	211	9	,	,	PUNCT
ijpds-4738	211	10	also	also	ADV
ijpds-4738	211	11	known	know	VERB
ijpds-4738	211	12	as	as	ADP
ijpds-4738	211	13	its	its	PRON
ijpds-4738	211	14	quantitation	quantitation	NOUN
ijpds-4738	211	15	limit	limit	NOUN
ijpds-4738	211	16	,	,	PUNCT
ijpds-4738	211	17	is	be	AUX
ijpds-4738	211	18	the	the	DET
ijpds-4738	211	19	smallest	small	ADJ
ijpds-4738	211	20	quantity	quantity	NOUN
ijpds-4738	211	21	of	of	ADP
ijpds-4738	211	22	analyte	analyte	NOUN
ijpds-4738	211	23	in	in	ADP
ijpds-4738	211	24	an	an	DET
ijpds-4738	211	25	experiment	experiment	NOUN
ijpds-4738	211	26	that	that	PRON
ijpds-4738	211	27	is	be	AUX
ijpds-4738	211	28	capable	capable	ADJ
ijpds-4738	211	29	of	of	ADP
ijpds-4738	211	30	being	be	AUX
ijpds-4738	211	31	quantitatively	quantitatively	ADV
ijpds-4738	211	32	measured	measure	VERB
ijpds-4738	211	33	with	with	ADP
ijpds-4738	211	34	appropriate	appropriate	ADJ
ijpds-4738	211	35	precision	precision	NOUN
ijpds-4738	211	36	and	and	CCONJ
ijpds-4738	211	37	accuracy	accuracy	NOUN
ijpds-4738	211	38	.	.	PUNCT
ijpds-4738	212	1	the	the	DET
ijpds-4738	212	2	loq	loq	PROPN
ijpds-4738	212	3	is	be	AUX
ijpds-4738	212	4	often	often	ADV
ijpds-4738	212	5	determined	determine	VERB
ijpds-4738	212	6	from	from	ADP
ijpds-4738	212	7	a	a	DET
ijpds-4738	212	8	s	s	PROPN
ijpds-4738	212	9	/	/	SYM
ijpds-4738	212	10	n	n	NOUN
ijpds-4738	212	11	ratio	ratio	NOUN
ijpds-4738	212	12	(	(	PUNCT
ijpds-4738	212	13	10:1	10:1	NUM
ijpds-4738	212	14	)	)	PUNCT
ijpds-4738	212	15	for	for	ADP
ijpds-4738	212	16	analytical	analytical	ADJ
ijpds-4738	212	17	processes	process	NOUN
ijpds-4738	212	18	that	that	PRON
ijpds-4738	212	19	display	display	VERB
ijpds-4738	212	20	baseline	baseline	NOUN
ijpds-4738	212	21	noise	noise	NOUN
ijpds-4738	212	22	,	,	PUNCT
ijpds-4738	212	23	and	and	CCONJ
ijpds-4738	212	24	it	it	PRON
ijpds-4738	212	25	is	be	AUX
ijpds-4738	212	26	typically	typically	ADV
ijpds-4738	212	27	validated	validate	VERB
ijpds-4738	212	28	by	by	ADP
ijpds-4738	212	29	injecting	inject	VERB
ijpds-4738	212	30	standards	standard	NOUN
ijpds-4738	212	31	that	that	PRON
ijpds-4738	212	32	both	both	PRON
ijpds-4738	212	33	meet	meet	VERB
ijpds-4738	212	34	an	an	DET
ijpds-4738	212	35	acceptable	acceptable	ADJ
ijpds-4738	212	36	percent	percent	NOUN
ijpds-4738	212	37	absolute	absolute	ADJ
ijpds-4738	212	38	standard	standard	ADJ
ijpds-4738	212	39	deviation	deviation	NOUN
ijpds-4738	212	40	and	and	CCONJ
ijpds-4738	212	41	this	this	DET
ijpds-4738	212	42	s	s	NOUN
ijpds-4738	212	43	/	/	SYM
ijpds-4738	212	44	n	n	NOUN
ijpds-4738	212	45	ratio	ratio	NOUN
ijpds-4738	213	1	[	[	X
ijpds-4738	213	2	41	41	NUM
ijpds-4738	213	3	,	,	PUNCT
ijpds-4738	213	4	42	42	NUM
ijpds-4738	213	5	]	]	PUNCT
ijpds-4738	213	6	.	.	PUNCT
ijpds-4738	214	1	f	f	X
ijpds-4738	214	2	)	)	PUNCT
ijpds-4738	214	3	specificity	specificity	NOUN
ijpds-4738	214	4	every	every	DET
ijpds-4738	214	5	development	development	NOUN
ijpds-4738	214	6	step	step	NOUN
ijpds-4738	214	7	should	should	AUX
ijpds-4738	214	8	see	see	VERB
ijpds-4738	214	9	a	a	DET
ijpds-4738	214	10	specificity	specificity	NOUN
ijpds-4738	214	11	in	in	ADP
ijpds-4738	214	12	the	the	DET
ijpds-4738	214	13	analytical	analytical	ADJ
ijpds-4738	214	14	method	method	NOUN
ijpds-4738	214	15	.	.	PUNCT
ijpds-4738	215	1	the	the	DET
ijpds-4738	215	2	method	method	NOUN
ijpds-4738	215	3	should	should	AUX
ijpds-4738	215	4	be	be	AUX
ijpds-4738	215	5	able	able	ADJ
ijpds-4738	215	6	to	to	PART
ijpds-4738	215	7	conclusively	conclusively	ADV
ijpds-4738	215	8	determine	determine	VERB
ijpds-4738	215	9	if	if	SCONJ
ijpds-4738	215	10	the	the	DET
ijpds-4738	215	11	target	target	NOUN
ijpds-4738	215	12	analyte	analyte	NOUN
ijpds-4738	215	13	is	be	AUX
ijpds-4738	215	14	present	present	ADJ
ijpds-4738	215	15	in	in	ADP
ijpds-4738	215	16	the	the	DET
ijpds-4738	215	17	presence	presence	NOUN
ijpds-4738	215	18	of	of	ADP
ijpds-4738	215	19	every	every	DET
ijpds-4738	215	20	anticipated	anticipate	VERB
ijpds-4738	215	21	component	component	NOUN
ijpds-4738	215	22	,	,	PUNCT
ijpds-4738	215	23	including	include	VERB
ijpds-4738	215	24	sample	sample	NOUN
ijpds-4738	215	25	blank	blank	ADJ
ijpds-4738	215	26	peaks	peak	NOUN
ijpds-4738	215	27	,	,	PUNCT
ijpds-4738	215	28	excipients	excipient	NOUN
ijpds-4738	215	29	,	,	PUNCT
ijpds-4738	215	30	degradants	degradant	NOUN
ijpds-4738	215	31	,	,	PUNCT
ijpds-4738	215	32	and	and	CCONJ
ijpds-4738	215	33	sample	sample	NOUN
ijpds-4738	215	34	matrix	matrix	NOUN
ijpds-4738	215	35	[	[	X
ijpds-4738	215	36	43	43	NUM
ijpds-4738	215	37	]	]	PUNCT
ijpds-4738	215	38	.	.	PUNCT
ijpds-4738	216	1	to	to	PART
ijpds-4738	216	2	ascertain	ascertain	VERB
ijpds-4738	216	3	how	how	SCONJ
ijpds-4738	216	4	long	long	ADV
ijpds-4738	216	5	each	each	DET
ijpds-4738	216	6	medication	medication	NOUN
ijpds-4738	216	7	would	would	AUX
ijpds-4738	216	8	remain	remain	VERB
ijpds-4738	216	9	in	in	ADP
ijpds-4738	216	10	the	the	DET
ijpds-4738	216	11	sample	sample	NOUN
ijpds-4738	216	12	and	and	CCONJ
ijpds-4738	216	13	in	in	ADP
ijpds-4738	216	14	a	a	DET
ijpds-4738	216	15	combination	combination	NOUN
ijpds-4738	216	16	,	,	PUNCT
ijpds-4738	216	17	specificity	specificity	NOUN
ijpds-4738	216	18	testing	testing	NOUN
ijpds-4738	216	19	was	be	AUX
ijpds-4738	216	20	done	do	VERB
ijpds-4738	216	21	.	.	PUNCT
ijpds-4738	217	1	when	when	SCONJ
ijpds-4738	217	2	the	the	DET
ijpds-4738	217	3	standard	standard	ADJ
ijpds-4738	217	4	medications	medication	NOUN
ijpds-4738	217	5	were	be	AUX
ijpds-4738	217	6	tested	test	VERB
ijpds-4738	217	7	separately	separately	ADV
ijpds-4738	217	8	,	,	PUNCT
ijpds-4738	217	9	their	their	PRON
ijpds-4738	217	10	respective	respective	ADJ
ijpds-4738	217	11	retention	retention	NOUN
ijpds-4738	217	12	times	time	NOUN
ijpds-4738	217	13	were	be	AUX
ijpds-4738	217	14	found	find	VERB
ijpds-4738	217	15	to	to	PART
ijpds-4738	217	16	be	be	AUX
ijpds-4738	217	17	3.750	3.750	NUM
ijpds-4738	217	18	min	min	NOUN
ijpds-4738	217	19	for	for	ADP
ijpds-4738	217	20	nitazoxanide	nitazoxanide	NOUN
ijpds-4738	217	21	and	and	CCONJ
ijpds-4738	217	22	1.533	1.533	NUM
ijpds-4738	217	23	min	min	NOUN
ijpds-4738	217	24	for	for	ADP
ijpds-4738	217	25	ofloxacin	ofloxacin	NOUN
ijpds-4738	217	26	.	.	PUNCT
ijpds-4738	218	1	when	when	SCONJ
ijpds-4738	218	2	the	the	DET
ijpds-4738	218	3	drugs	drug	NOUN
ijpds-4738	218	4	were	be	AUX
ijpds-4738	218	5	tested	test	VERB
ijpds-4738	218	6	together	together	ADV
ijpds-4738	218	7	,	,	PUNCT
ijpds-4738	218	8	their	their	PRON
ijpds-4738	218	9	respective	respective	ADJ
ijpds-4738	218	10	retention	retention	NOUN
ijpds-4738	218	11	times	time	NOUN
ijpds-4738	218	12	were	be	AUX
ijpds-4738	218	13	found	find	VERB
ijpds-4738	218	14	to	to	PART
ijpds-4738	218	15	be	be	AUX
ijpds-4738	218	16	3.760	3.760	NUM
ijpds-4738	218	17	min	min	NOUN
ijpds-4738	218	18	with	with	ADP
ijpds-4738	218	19	nitazoxanide	nitazoxanide	NOUN
ijpds-4738	218	20	and	and	CCONJ
ijpds-4738	218	21	1.542	1.542	NUM
ijpds-4738	218	22	min	min	NOUN
ijpds-4738	218	23	for	for	ADP
ijpds-4738	218	24	ofloxacin	ofloxacin	NOUN
ijpds-4738	218	25	.	.	PUNCT
ijpds-4738	219	1	g	g	NOUN
ijpds-4738	219	2	)	)	PUNCT
ijpds-4738	219	3	range	range	VERB
ijpds-4738	219	4	the	the	DET
ijpds-4738	219	5	analytical	analytical	ADJ
ijpds-4738	219	6	techniques	technique	NOUN
ijpds-4738	219	7	range	range	NOUN
ijpds-4738	219	8	is	be	AUX
ijpds-4738	219	9	the	the	DET
ijpds-4738	219	10	range	range	NOUN
ijpds-4738	219	11	of	of	ADP
ijpds-4738	219	12	a	a	DET
ijpds-4738	219	13	compound	compound	NOUN
ijpds-4738	219	14	's	's	PART
ijpds-4738	219	15	concentration	concentration	NOUN
ijpds-4738	219	16	inside	inside	ADP
ijpds-4738	219	17	the	the	DET
ijpds-4738	219	18	sample	sample	NOUN
ijpds-4738	219	19	between	between	ADP
ijpds-4738	219	20	its	its	PRON
ijpds-4738	219	21	highest	high	ADJ
ijpds-4738	219	22	and	and	CCONJ
ijpds-4738	219	23	minimum	minimum	ADJ
ijpds-4738	219	24	levels	level	NOUN
ijpds-4738	219	25	at	at	ADP
ijpds-4738	219	26	which	which	PRON
ijpds-4738	219	27	the	the	DET
ijpds-4738	219	28	linearity	linearity	NOUN
ijpds-4738	219	29	,	,	PUNCT
ijpds-4738	219	30	precision	precision	NOUN
ijpds-4738	219	31	,	,	PUNCT
ijpds-4738	219	32	and	and	CCONJ
ijpds-4738	219	33	accuracy	accuracy	NOUN
ijpds-4738	219	34	of	of	ADP
ijpds-4738	219	35	the	the	DET
ijpds-4738	219	36	analytical	analytical	ADJ
ijpds-4738	219	37	method	method	NOUN
ijpds-4738	219	38	can	can	AUX
ijpds-4738	219	39	be	be	AUX
ijpds-4738	219	40	shown	show	VERB
ijpds-4738	219	41	to	to	PART
ijpds-4738	219	42	be	be	AUX
ijpds-4738	219	43	sufficient	sufficient	ADJ
ijpds-4738	219	44	.	.	PUNCT
ijpds-4738	220	1	the	the	DET
ijpds-4738	220	2	range	range	NOUN
ijpds-4738	220	3	is	be	AUX
ijpds-4738	220	4	often	often	ADV
ijpds-4738	220	5	given	give	VERB
ijpds-4738	220	6	in	in	ADP
ijpds-4738	220	7	percentages	percentage	NOUN
ijpds-4738	220	8	or	or	CCONJ
ijpds-4738	220	9	parts	part	NOUN
ijpds-4738	220	10	per	per	ADP
ijpds-4738	220	11	million	million	NUM
ijpds-4738	220	12	,	,	PUNCT
ijpds-4738	220	13	much	much	ADV
ijpds-4738	220	14	like	like	ADP
ijpds-4738	220	15	the	the	DET
ijpds-4738	220	16	test	test	NOUN
ijpds-4738	220	17	results	result	NOUN
ijpds-4738	220	18	generated	generate	VERB
ijpds-4738	220	19	by	by	ADP
ijpds-4738	220	20	the	the	DET
ijpds-4738	220	21	analytical	analytical	ADJ
ijpds-4738	220	22	technique	technique	NOUN
ijpds-4738	220	23	.	.	PUNCT
ijpds-4738	221	1	1	1	X
ijpds-4738	221	2	.	.	X
ijpds-4738	222	1	80–1200	80–1200	NUM
ijpds-4738	222	2	%	%	NOUN
ijpds-4738	222	3	of	of	ADP
ijpds-4738	222	4	the	the	DET
ijpds-4738	222	5	test	test	NOUN
ijpds-4738	222	6	concentration	concentration	NOUN
ijpds-4738	222	7	is	be	AUX
ijpds-4738	222	8	used	use	VERB
ijpds-4738	222	9	in	in	ADP
ijpds-4738	222	10	the	the	DET
ijpds-4738	222	11	experiment	experiment	NOUN
ijpds-4738	222	12	.	.	PUNCT
ijpds-4738	223	1	2	2	X
ijpds-4738	223	2	.	.	X
ijpds-4738	223	3	consistency	consistency	NOUN
ijpds-4738	223	4	of	of	ADP
ijpds-4738	223	5	content	content	NOUN
ijpds-4738	223	6	and	and	CCONJ
ijpds-4738	223	7	test	test	NOUN
ijpds-4738	223	8	concentration	concentration	NOUN
ijpds-4738	223	9	between	between	ADP
ijpds-4738	223	10	70	70	NUM
ijpds-4738	223	11	–	–	PUNCT
ijpds-4738	223	12	130	130	NUM
ijpds-4738	223	13	%	%	NOUN
ijpds-4738	223	14	3	3	NUM
ijpds-4738	223	15	.	.	NOUN
ijpds-4738	223	16	impurities	impurity	NOUN
ijpds-4738	223	17	:	:	PUNCT
ijpds-4738	223	18	120	120	NUM
ijpds-4738	223	19	%	%	NOUN
ijpds-4738	223	20	of	of	ADP
ijpds-4738	223	21	the	the	DET
ijpds-4738	223	22	recommended	recommend	VERB
ijpds-4738	223	23	level	level	NOUN
ijpds-4738	223	24	is	be	AUX
ijpds-4738	223	25	the	the	DET
ijpds-4738	223	26	reporting	reporting	NOUN
ijpds-4738	223	27	threshold	threshold	NOUN
ijpds-4738	223	28	for	for	ADP
ijpds-4738	223	29	impurities	impurity	NOUN
ijpds-4738	223	30	.	.	PUNCT
ijpds-4738	224	1	test	test	NOUN
ijpds-4738	224	2	and	and	CCONJ
ijpds-4738	224	3	impurities	impurity	NOUN
ijpds-4738	224	4	:	:	PUNCT
ijpds-4738	224	5	up	up	ADP
ijpds-4738	224	6	to	to	PART
ijpds-4738	224	7	120	120	NUM
ijpds-4738	224	8	%	%	NOUN
ijpds-4738	224	9	of	of	ADP
ijpds-4738	224	10	the	the	DET
ijpds-4738	224	11	test	test	NOUN
ijpds-4738	224	12	-	-	PUNCT
ijpds-4738	224	13	specific	specific	ADJ
ijpds-4738	224	14	reporting	reporting	NOUN
ijpds-4738	224	15	criteria	criterion	NOUN
ijpds-4738	224	16	.	.	PUNCT
ijpds-4738	225	1	4	4	X
ijpds-4738	225	2	.	.	X
ijpds-4738	225	3	q-20	q-20	ADJ
ijpds-4738	225	4	%	%	NOUN
ijpds-4738	225	5	solubility	solubility	NOUN
ijpds-4738	225	6	to	to	ADP
ijpds-4738	225	7	120	120	NUM
ijpds-4738	225	8	%	%	NOUN
ijpds-4738	225	9	[	[	X
ijpds-4738	225	10	44	44	NUM
ijpds-4738	225	11	]	]	PUNCT
ijpds-4738	225	12	.	.	PUNCT
ijpds-4738	226	1	a	a	DET
ijpds-4738	226	2	)	)	PUNCT
ijpds-4738	226	3	b	b	NOUN
ijpds-4738	226	4	)	)	PUNCT
ijpds-4738	226	5	c	c	NOUN
ijpds-4738	226	6	)	)	PUNCT
ijpds-4738	226	7	a	a	DET
ijpds-4738	226	8	)	)	PUNCT
ijpds-4738	226	9	linear	linear	PROPN
ijpds-4738	226	10	b	b	X
ijpds-4738	226	11	)	)	PUNCT
ijpds-4738	226	12	non	non	ADJ
ijpds-4738	226	13	-	-	ADJ
ijpds-4738	226	14	linear	linear	ADJ
ijpds-4738	226	15	figure	figure	NOUN
ijpds-4738	226	16	2	2	NUM
ijpds-4738	226	17	.	.	PUNCT
ijpds-4738	226	18	plot	plot	NOUN
ijpds-4738	226	19	for	for	ADP
ijpds-4738	226	20	ranges	range	NOUN
ijpds-4738	226	21	of	of	ADP
ijpds-4738	226	22	an	an	DET
ijpds-4738	226	23	analytical	analytical	ADJ
ijpds-4738	226	24	technique	technique	NOUN
ijpds-4738	226	25	h	h	NOUN
ijpds-4738	226	26	)	)	PUNCT
ijpds-4738	226	27	robustness	robustness	VERB
ijpds-4738	226	28	the	the	DET
ijpds-4738	226	29	robustness	robustness	NOUN
ijpds-4738	226	30	of	of	ADP
ijpds-4738	226	31	an	an	DET
ijpds-4738	226	32	analytical	analytical	ADJ
ijpds-4738	226	33	method	method	NOUN
ijpds-4738	226	34	is	be	AUX
ijpds-4738	226	35	defined	define	VERB
ijpds-4738	226	36	as	as	ADP
ijpds-4738	226	37	the	the	DET
ijpds-4738	226	38	degree	degree	NOUN
ijpds-4738	226	39	of	of	ADP
ijpds-4738	226	40	repeatability	repeatability	NOUN
ijpds-4738	226	41	of	of	ADP
ijpds-4738	226	42	test	test	NOUN
ijpds-4738	226	43	results	result	NOUN
ijpds-4738	226	44	via	via	ADP
ijpds-4738	226	45	the	the	DET
ijpds-4738	226	46	same	same	ADJ
ijpds-4738	226	47	samples	sample	NOUN
ijpds-4738	226	48	analysed	analyse	VERB
ijpds-4738	226	49	under	under	ADP
ijpds-4738	226	50	various	various	ADJ
ijpds-4738	226	51	standard	standard	ADJ
ijpds-4738	226	52	test	test	NOUN
ijpds-4738	226	53	conditions	condition	NOUN
ijpds-4738	226	54	,	,	PUNCT
ijpds-4738	226	55	which	which	PRON
ijpds-4738	226	56	could	could	AUX
ijpds-4738	226	57	include	include	VERB
ijpds-4738	226	58	different	different	ADJ
ijpds-4738	226	59	operators	operator	NOUN
ijpds-4738	226	60	,	,	PUNCT
ijpds-4738	226	61	different	different	ADJ
ijpds-4738	226	62	laboratories	laboratory	NOUN
ijpds-4738	226	63	,	,	PUNCT
ijpds-4738	226	64	and	and	CCONJ
ijpds-4738	226	65	possibly	possibly	ADV
ijpds-4738	226	66	different	different	ADJ
ijpds-4738	226	67	operational	operational	ADJ
ijpds-4738	226	68	along	along	ADP
ijpds-4738	226	69	with	with	ADP
ijpds-4738	226	70	environmental	environmental	ADJ
ijpds-4738	226	71	conditions	condition	NOUN
ijpds-4738	226	72	,	,	PUNCT
ijpds-4738	226	73	while	while	SCONJ
ijpds-4738	226	74	staying	stay	VERB
ijpds-4738	226	75	within	within	ADP
ijpds-4738	226	76	the	the	DET
ijpds-4738	226	77	assay	assay	NOUN
ijpds-4738	226	78	's	's	PART
ijpds-4738	226	79	defined	define	VERB
ijpds-4738	226	80	parameters	parameter	NOUN
ijpds-4738	226	81	.	.	PUNCT
ijpds-4738	227	1	testing	test	VERB
ijpds-4738	227	2	for	for	ADP
ijpds-4738	227	3	ruggedness	ruggedness	NOUN
ijpds-4738	227	4	is	be	AUX
ijpds-4738	227	5	typically	typically	ADV
ijpds-4738	227	6	suggested	suggest	VERB
ijpds-4738	227	7	when	when	SCONJ
ijpds-4738	227	8	the	the	DET
ijpds-4738	227	9	process	process	NOUN
ijpds-4738	227	10	will	will	AUX
ijpds-4738	227	11	be	be	AUX
ijpds-4738	227	12	used	use	VERB
ijpds-4738	227	13	in	in	ADP
ijpds-4738	227	14	several	several	ADJ
ijpds-4738	227	15	labs	lab	NOUN
ijpds-4738	227	16	.	.	PUNCT
ijpds-4738	228	1	ruggedness	ruggedness	NOUN
ijpds-4738	228	2	is	be	AUX
ijpds-4738	228	3	evaluated	evaluate	VERB
ijpds-4738	228	4	by	by	ADP
ijpds-4738	228	5	calculating	calculate	VERB
ijpds-4738	228	6	the	the	DET
ijpds-4738	228	7	degree	degree	NOUN
ijpds-4738	228	8	of	of	ADP
ijpds-4738	228	9	outcome	outcome	NOUN
ijpds-4738	228	10	repeatability	repeatability	NOUN
ijpds-4738	228	11	as	as	ADP
ijpds-4738	228	12	a	a	DET
ijpds-4738	228	13	function	function	NOUN
ijpds-4738	228	14	of	of	ADP
ijpds-4738	228	15	the	the	DET
ijpds-4738	228	16	test	test	NOUN
ijpds-4738	228	17	variable	variable	NOUN
ijpds-4738	228	18	.	.	PUNCT
ijpds-4738	229	1	this	this	DET
ijpds-4738	229	2	reproducibility	reproducibility	NOUN
ijpds-4738	229	3	could	could	AUX
ijpds-4738	229	4	be	be	AUX
ijpds-4738	229	5	used	use	VERB
ijpds-4738	229	6	to	to	PART
ijpds-4738	229	7	gauge	gauge	VERB
ijpds-4738	229	8	the	the	DET
ijpds-4738	229	9	analytical	analytical	ADJ
ijpds-4738	229	10	method	method	NOUN
ijpds-4738	229	11	's	's	PART
ijpds-4738	229	12	ruggedness	ruggedness	NOUN
ijpds-4738	229	13	by	by	ADP
ijpds-4738	229	14	comparing	compare	VERB
ijpds-4738	229	15	it	it	PRON
ijpds-4738	229	16	to	to	ADP
ijpds-4738	229	17	the	the	DET
ijpds-4738	229	18	assay	assay	NOUN
ijpds-4738	229	19	's	's	PART
ijpds-4738	229	20	accuracy	accuracy	NOUN
ijpds-4738	229	21	under	under	ADP
ijpds-4738	229	22	typical	typical	ADJ
ijpds-4738	229	23	conditions	condition	NOUN
ijpds-4738	229	24	[	[	X
ijpds-4738	229	25	45	45	NUM
ijpds-4738	229	26	]	]	PUNCT
ijpds-4738	229	27	.	.	PUNCT
ijpds-4738	230	1	i	i	PRON
ijpds-4738	230	2	)	)	PUNCT
ijpds-4738	230	3	system	system	NOUN
ijpds-4738	230	4	suitability	suitability	NOUN
ijpds-4738	230	5	determination	determination	NOUN
ijpds-4738	230	6	tests	test	VERB
ijpds-4738	230	7	for	for	ADP
ijpds-4738	230	8	system	system	NOUN
ijpds-4738	230	9	compatibility	compatibility	NOUN
ijpds-4738	230	10	are	be	AUX
ijpds-4738	230	11	an	an	DET
ijpds-4738	230	12	essential	essential	ADJ
ijpds-4738	230	13	component	component	NOUN
ijpds-4738	230	14	of	of	ADP
ijpds-4738	230	15	liquid	liquid	ADJ
ijpds-4738	230	16	chromatographic	chromatographic	ADJ
ijpds-4738	230	17	techniques	technique	NOUN
ijpds-4738	230	18	.	.	PUNCT
ijpds-4738	231	1	they	they	PRON
ijpds-4738	231	2	are	be	AUX
ijpds-4738	231	3	employed	employ	VERB
ijpds-4738	231	4	to	to	PART
ijpds-4738	231	5	confirm	confirm	VERB
ijpds-4738	231	6	that	that	SCONJ
ijpds-4738	231	7	the	the	DET
ijpds-4738	231	8	chromatographic	chromatographic	ADJ
ijpds-4738	231	9	systems	system	NOUN
ijpds-4738	231	10	detection	detection	NOUN
ijpds-4738	231	11	sensitivity	sensitivity	NOUN
ijpds-4738	231	12	,	,	PUNCT
ijpds-4738	231	13	resolution	resolution	NOUN
ijpds-4738	231	14	,	,	PUNCT
ijpds-4738	231	15	and	and	CCONJ
ijpds-4738	231	16	repeatability	repeatability	NOUN
ijpds-4738	231	17	are	be	AUX
ijpds-4738	231	18	sufficient	sufficient	ADJ
ijpds-4738	231	19	for	for	ADP
ijpds-4738	231	20	the	the	DET
ijpds-4738	231	21	intended	intend	VERB
ijpds-4738	231	22	analysis	analysis	NOUN
ijpds-4738	231	23	.	.	PUNCT
ijpds-4738	232	1	the	the	DET
ijpds-4738	232	2	foundation	foundation	NOUN
ijpds-4738	232	3	of	of	ADP
ijpds-4738	232	4	the	the	DET
ijpds-4738	232	5	testing	testing	NOUN
ijpds-4738	232	6	is	be	AUX
ijpds-4738	232	7	the	the	DET
ijpds-4738	232	8	idea	idea	NOUN
ijpds-4738	232	9	that	that	SCONJ
ijpds-4738	232	10	patil	patil	PROPN
ijpds-4738	232	11	et	et	PROPN
ijpds-4738	232	12	al	al	PROPN
ijpds-4738	232	13	.	.	PROPN
ijpds-4738	233	1	analytical	analytical	ADJ
ijpds-4738	233	2	method	method	PROPN
ijpds-4738	233	3	development	development	NOUN
ijpds-4738	233	4	and	and	CCONJ
ijpds-4738	233	5	validation	validation	NOUN
ijpds-4738	233	6	online	online	ADJ
ijpds-4738	233	7	first	first	PROPN
ijpds-4738	233	8	indian	indian	PROPN
ijpds-4738	233	9	j	j	PROPN
ijpds-4738	233	10	pharm	pharm	PROPN
ijpds-4738	233	11	drug	drug	PROPN
ijpds-4738	233	12	studies	study	NOUN
ijpds-4738	233	13	|	|	ADV
ijpds-4738	233	14	6	6	NUM
ijpds-4738	233	15	the	the	DET
ijpds-4738	233	16	tools	tool	NOUN
ijpds-4738	233	17	,	,	PUNCT
ijpds-4738	233	18	electronics	electronic	NOUN
ijpds-4738	233	19	,	,	PUNCT
ijpds-4738	233	20	processes	process	NOUN
ijpds-4738	233	21	involved	involve	VERB
ijpds-4738	233	22	in	in	ADP
ijpds-4738	233	23	the	the	DET
ijpds-4738	233	24	analysis	analysis	NOUN
ijpds-4738	233	25	,	,	PUNCT
ijpds-4738	233	26	and	and	CCONJ
ijpds-4738	233	27	materials	material	NOUN
ijpds-4738	233	28	to	to	PART
ijpds-4738	233	29	be	be	AUX
ijpds-4738	233	30	examined	examine	VERB
ijpds-4738	233	31	all	all	DET
ijpds-4738	233	32	work	work	NOUN
ijpds-4738	233	33	together	together	ADV
ijpds-4738	233	34	as	as	ADP
ijpds-4738	233	35	a	a	DET
ijpds-4738	233	36	cohesive	cohesive	ADJ
ijpds-4738	233	37	system	system	NOUN
ijpds-4738	233	38	that	that	PRON
ijpds-4738	233	39	is	be	AUX
ijpds-4738	233	40	capable	capable	ADJ
ijpds-4738	233	41	of	of	ADP
ijpds-4738	233	42	being	be	AUX
ijpds-4738	233	43	assessed	assess	VERB
ijpds-4738	233	44	as	as	ADP
ijpds-4738	233	45	such	such	ADJ
ijpds-4738	233	46	.	.	PUNCT
ijpds-4738	234	1	measurements	measurement	NOUN
ijpds-4738	234	2	have	have	AUX
ijpds-4738	234	3	been	be	AUX
ijpds-4738	234	4	made	make	VERB
ijpds-4738	234	5	of	of	ADP
ijpds-4738	234	6	peak	peak	NOUN
ijpds-4738	234	7	resolution	resolution	NOUN
ijpds-4738	234	8	,	,	PUNCT
ijpds-4738	234	9	number	number	NOUN
ijpds-4738	234	10	of	of	ADP
ijpds-4738	234	11	theoretical	theoretical	ADJ
ijpds-4738	234	12	plates	plate	NOUN
ijpds-4738	234	13	can	can	AUX
ijpds-4738	234	14	,	,	PUNCT
ijpds-4738	234	15	peak	peak	NOUN
ijpds-4738	234	16	tailing	tailing	NOUN
ijpds-4738	234	17	,	,	PUNCT
ijpds-4738	234	18	and	and	CCONJ
ijpds-4738	234	19	capacity	capacity	NOUN
ijpds-4738	234	20	to	to	PART
ijpds-4738	234	21	assess	assess	VERB
ijpds-4738	234	22	the	the	DET
ijpds-4738	234	23	applicability	applicability	NOUN
ijpds-4738	234	24	of	of	ADP
ijpds-4738	234	25	the	the	DET
ijpds-4738	234	26	used	use	VERB
ijpds-4738	234	27	technique	technique	NOUN
ijpds-4738	234	28	[	[	X
ijpds-4738	234	29	45	45	NUM
ijpds-4738	234	30	]	]	PUNCT
ijpds-4738	234	31	.	.	PUNCT
ijpds-4738	235	1	j	j	NOUN
ijpds-4738	235	2	)	)	PUNCT
ijpds-4738	235	3	forced	force	VERB
ijpds-4738	235	4	degradation	degradation	NOUN
ijpds-4738	235	5	studies	study	NOUN
ijpds-4738	235	6	in	in	ADP
ijpds-4738	235	7	order	order	NOUN
ijpds-4738	235	8	to	to	PART
ijpds-4738	235	9	purposefully	purposefully	ADV
ijpds-4738	235	10	deteriorate	deteriorate	VERB
ijpds-4738	235	11	the	the	DET
ijpds-4738	235	12	sample	sample	NOUN
ijpds-4738	235	13	,	,	PUNCT
ijpds-4738	235	14	stress	stress	NOUN
ijpds-4738	235	15	experiments	experiment	NOUN
ijpds-4738	235	16	or	or	CCONJ
ijpds-4738	235	17	forced	force	VERB
ijpds-4738	235	18	degradation	degradation	NOUN
ijpds-4738	235	19	are	be	AUX
ijpds-4738	235	20	conducted	conduct	VERB
ijpds-4738	235	21	.	.	PUNCT
ijpds-4738	236	1	by	by	ADP
ijpds-4738	236	2	producing	produce	VERB
ijpds-4738	236	3	possible	possible	ADJ
ijpds-4738	236	4	degradation	degradation	NOUN
ijpds-4738	236	5	products	product	NOUN
ijpds-4738	236	6	,	,	PUNCT
ijpds-4738	236	7	these	these	DET
ijpds-4738	236	8	investigations	investigation	NOUN
ijpds-4738	236	9	assess	assess	VERB
ijpds-4738	236	10	an	an	DET
ijpds-4738	236	11	analytical	analytical	ADJ
ijpds-4738	236	12	method	method	NOUN
ijpds-4738	236	13	's	's	PART
ijpds-4738	236	14	capacity	capacity	NOUN
ijpds-4738	236	15	to	to	PART
ijpds-4738	236	16	quantify	quantify	VERB
ijpds-4738	236	17	an	an	DET
ijpds-4738	236	18	active	active	ADJ
ijpds-4738	236	19	chemical	chemical	NOUN
ijpds-4738	236	20	and	and	CCONJ
ijpds-4738	236	21	its	its	PRON
ijpds-4738	236	22	breakdown	breakdown	ADJ
ijpds-4738	236	23	products	product	NOUN
ijpds-4738	236	24	independently	independently	ADV
ijpds-4738	236	25	.	.	PUNCT
ijpds-4738	237	1	drug	drug	NOUN
ijpds-4738	237	2	materials	material	NOUN
ijpds-4738	237	3	are	be	AUX
ijpds-4738	237	4	subjected	subject	VERB
ijpds-4738	237	5	to	to	ADP
ijpds-4738	237	6	acid	acid	NOUN
ijpds-4738	237	7	,	,	PUNCT
ijpds-4738	237	8	base	base	NOUN
ijpds-4738	237	9	,	,	PUNCT
ijpds-4738	237	10	heat	heat	NOUN
ijpds-4738	237	11	,	,	PUNCT
ijpds-4738	237	12	light	light	NOUN
ijpds-4738	237	13	,	,	PUNCT
ijpds-4738	237	14	and	and	CCONJ
ijpds-4738	237	15	oxidizing	oxidize	VERB
ijpds-4738	237	16	agents	agent	NOUN
ijpds-4738	237	17	during	during	ADP
ijpds-4738	237	18	method	method	NOUN
ijpds-4738	237	19	validation	validation	NOUN
ijpds-4738	237	20	,	,	PUNCT
ijpds-4738	237	21	resulting	result	VERB
ijpds-4738	237	22	in	in	ADP
ijpds-4738	237	23	10	10	NUM
ijpds-4738	237	24	%	%	NOUN
ijpds-4738	237	25	to	to	PART
ijpds-4738	237	26	30	30	NUM
ijpds-4738	237	27	%	%	NOUN
ijpds-4738	237	28	degradation	degradation	NOUN
ijpds-4738	237	29	of	of	ADP
ijpds-4738	237	30	the	the	DET
ijpds-4738	237	31	active	active	ADJ
ijpds-4738	237	32	ingredient	ingredient	NOUN
ijpds-4738	237	33	.	.	PUNCT
ijpds-4738	238	1	forced	force	VERB
ijpds-4738	238	2	degradation	degradation	NOUN
ijpds-4738	238	3	studies	study	NOUN
ijpds-4738	238	4	are	be	AUX
ijpds-4738	238	5	conducted	conduct	VERB
ijpds-4738	238	6	for	for	ADP
ijpds-4738	238	7	various	various	ADJ
ijpds-4738	238	8	reasons	reason	NOUN
ijpds-4738	238	9	,	,	PUNCT
ijpds-4738	238	10	such	such	ADJ
ijpds-4738	238	11	as	as	ADP
ijpds-4738	238	12	developing	develop	VERB
ijpds-4738	238	13	and	and	CCONJ
ijpds-4738	238	14	validating	validate	VERB
ijpds-4738	238	15	stability	stability	NOUN
ijpds-4738	238	16	-	-	PUNCT
ijpds-4738	238	17	indicating	indicate	VERB
ijpds-4738	238	18	methodology	methodology	NOUN
ijpds-4738	238	19	,	,	PUNCT
ijpds-4738	238	20	identifying	identify	VERB
ijpds-4738	238	21	drug	drug	NOUN
ijpds-4738	238	22	substances	substance	NOUN
ijpds-4738	238	23	as	as	ADV
ijpds-4738	238	24	well	well	ADV
ijpds-4738	238	25	as	as	ADP
ijpds-4738	238	26	drug	drug	NOUN
ijpds-4738	238	27	product	product	NOUN
ijpds-4738	238	28	degradation	degradation	NOUN
ijpds-4738	238	29	pathways	pathway	NOUN
ijpds-4738	238	30	,	,	PUNCT
ijpds-4738	238	31	and	and	CCONJ
ijpds-4738	238	32	differentiating	differentiate	VERB
ijpds-4738	238	33	between	between	ADP
ijpds-4738	238	34	degradation	degradation	NOUN
ijpds-4738	238	35	products	product	NOUN
ijpds-4738	238	36	in	in	ADP
ijpds-4738	238	37	formulations	formulation	NOUN
ijpds-4738	238	38	related	relate	VERB
ijpds-4738	238	39	to	to	ADP
ijpds-4738	238	40	drug	drug	NOUN
ijpds-4738	238	41	substances	substance	NOUN
ijpds-4738	238	42	and	and	CCONJ
ijpds-4738	238	43	those	those	PRON
ijpds-4738	238	44	related	relate	VERB
ijpds-4738	238	45	to	to	ADP
ijpds-4738	238	46	non	non	ADJ
ijpds-4738	238	47	-	-	ADJ
ijpds-4738	238	48	drug	drug	ADJ
ijpds-4738	238	49	substances	substance	NOUN
ijpds-4738	238	50	[	[	X
ijpds-4738	238	51	45	45	NUM
ijpds-4738	238	52	]	]	PUNCT
ijpds-4738	238	53	.	.	PUNCT
ijpds-4738	239	1	k	k	X
ijpds-4738	239	2	)	)	PUNCT
ijpds-4738	239	3	stability	stability	NOUN
ijpds-4738	239	4	studies	study	VERB
ijpds-4738	239	5	the	the	DET
ijpds-4738	239	6	durability	durability	NOUN
ijpds-4738	239	7	of	of	ADP
ijpds-4738	239	8	both	both	DET
ijpds-4738	239	9	samples	sample	NOUN
ijpds-4738	239	10	and	and	CCONJ
ijpds-4738	239	11	standards	standard	NOUN
ijpds-4738	239	12	is	be	AUX
ijpds-4738	239	13	determined	determine	VERB
ijpds-4738	239	14	during	during	ADP
ijpds-4738	239	15	validation	validation	NOUN
ijpds-4738	239	16	under	under	ADP
ijpds-4738	239	17	typical	typical	ADJ
ijpds-4738	239	18	circumstances	circumstance	NOUN
ijpds-4738	239	19	,	,	PUNCT
ijpds-4738	239	20	under	under	ADP
ijpds-4738	239	21	typical	typical	ADJ
ijpds-4738	239	22	storage	storage	NOUN
ijpds-4738	239	23	settings	setting	NOUN
ijpds-4738	239	24	,	,	PUNCT
ijpds-4738	239	25	and	and	CCONJ
ijpds-4738	239	26	occasionally	occasionally	ADV
ijpds-4738	239	27	within	within	ADP
ijpds-4738	239	28	the	the	DET
ijpds-4738	239	29	instrument	instrument	NOUN
ijpds-4738	239	30	to	to	PART
ijpds-4738	239	31	ascertain	ascertain	VERB
ijpds-4738	239	32	whether	whether	SCONJ
ijpds-4738	239	33	specific	specific	ADJ
ijpds-4738	239	34	storage	storage	NOUN
ijpds-4738	239	35	conditions	condition	NOUN
ijpds-4738	239	36	—	—	PUNCT
ijpds-4738	239	37	such	such	ADJ
ijpds-4738	239	38	as	as	ADP
ijpds-4738	239	39	refrigeration	refrigeration	NOUN
ijpds-4738	239	40	or	or	CCONJ
ijpds-4738	239	41	light	light	NOUN
ijpds-4738	239	42	protection	protection	NOUN
ijpds-4738	239	43	are	be	AUX
ijpds-4738	239	44	required	require	VERB
ijpds-4738	239	45	[	[	PUNCT
ijpds-4738	239	46	45	45	NUM
ijpds-4738	239	47	]	]	PUNCT
ijpds-4738	239	48	.	.	PUNCT
ijpds-4738	240	1	conclusion	conclusion	NOUN
ijpds-4738	240	2	the	the	DET
ijpds-4738	240	3	aim	aim	NOUN
ijpds-4738	240	4	of	of	ADP
ijpds-4738	240	5	every	every	DET
ijpds-4738	240	6	analytical	analytical	ADJ
ijpds-4738	240	7	measurement	measurement	NOUN
ijpds-4738	240	8	is	be	AUX
ijpds-4738	240	9	to	to	PART
ijpds-4738	240	10	generate	generate	VERB
ijpds-4738	240	11	data	datum	NOUN
ijpds-4738	240	12	that	that	PRON
ijpds-4738	240	13	is	be	AUX
ijpds-4738	240	14	consistent	consistent	ADJ
ijpds-4738	240	15	,	,	PUNCT
ijpds-4738	240	16	accurate	accurate	ADJ
ijpds-4738	240	17	,	,	PUNCT
ijpds-4738	240	18	and	and	CCONJ
ijpds-4738	240	19	reliable	reliable	ADJ
ijpds-4738	240	20	.	.	PUNCT
ijpds-4738	241	1	these	these	DET
ijpds-4738	241	2	techniques	technique	NOUN
ijpds-4738	241	3	are	be	AUX
ijpds-4738	241	4	employed	employ	VERB
ijpds-4738	241	5	to	to	PART
ijpds-4738	241	6	guarantee	guarantee	VERB
ijpds-4738	241	7	drug	drug	NOUN
ijpds-4738	241	8	authenticity	authenticity	NOUN
ijpds-4738	241	9	,	,	PUNCT
ijpds-4738	241	10	potency	potency	NOUN
ijpds-4738	241	11	,	,	PUNCT
ijpds-4738	241	12	purity	purity	NOUN
ijpds-4738	241	13	,	,	PUNCT
ijpds-4738	241	14	and	and	CCONJ
ijpds-4738	241	15	effectiveness	effectiveness	NOUN
ijpds-4738	241	16	.	.	PUNCT
ijpds-4738	242	1	these	these	DET
ijpds-4738	242	2	state	state	NOUN
ijpds-4738	242	3	about	about	ADP
ijpds-4738	242	4	various	various	ADJ
ijpds-4738	242	5	parameters	parameter	NOUN
ijpds-4738	242	6	and	and	CCONJ
ijpds-4738	242	7	techniques	technique	NOUN
ijpds-4738	242	8	,	,	PUNCT
ijpds-4738	242	9	which	which	PRON
ijpds-4738	242	10	shows	show	VERB
ijpds-4738	242	11	that	that	PRON
ijpds-4738	242	12	are	be	AUX
ijpds-4738	242	13	suitable	suitable	ADJ
ijpds-4738	242	14	for	for	ADP
ijpds-4738	242	15	the	the	DET
ijpds-4738	242	16	procedure	procedure	NOUN
ijpds-4738	242	17	and	and	CCONJ
ijpds-4738	242	18	can	can	AUX
ijpds-4738	242	19	be	be	AUX
ijpds-4738	242	20	developed	develop	VERB
ijpds-4738	242	21	for	for	ADP
ijpds-4738	242	22	the	the	DET
ijpds-4738	242	23	tests	test	NOUN
ijpds-4738	242	24	.	.	PUNCT
ijpds-4738	243	1	in	in	ADP
ijpds-4738	243	2	this	this	DET
ijpds-4738	243	3	article	article	NOUN
ijpds-4738	243	4	,	,	PUNCT
ijpds-4738	243	5	we	we	PRON
ijpds-4738	243	6	have	have	AUX
ijpds-4738	243	7	discussed	discuss	VERB
ijpds-4738	243	8	how	how	SCONJ
ijpds-4738	243	9	validation	validation	NOUN
ijpds-4738	243	10	was	be	AUX
ijpds-4738	243	11	carried	carry	VERB
ijpds-4738	243	12	out	out	ADP
ijpds-4738	243	13	with	with	ADP
ijpds-4738	243	14	the	the	DET
ijpds-4738	243	15	use	use	NOUN
ijpds-4738	243	16	of	of	ADP
ijpds-4738	243	17	specific	specific	ADJ
ijpds-4738	243	18	validation	validation	NOUN
ijpds-4738	243	19	parameters	parameter	NOUN
ijpds-4738	243	20	—	—	PUNCT
ijpds-4738	243	21	including	include	VERB
ijpds-4738	243	22	linearity	linearity	NOUN
ijpds-4738	243	23	,	,	PUNCT
ijpds-4738	243	24	loq	loq	PROPN
ijpds-4738	243	25	,	,	PUNCT
ijpds-4738	243	26	lod	lod	PROPN
ijpds-4738	243	27	,	,	PUNCT
ijpds-4738	243	28	range	range	NOUN
ijpds-4738	243	29	,	,	PUNCT
ijpds-4738	243	30	robustness	robustness	NOUN
ijpds-4738	243	31	,	,	PUNCT
ijpds-4738	243	32	and	and	CCONJ
ijpds-4738	243	33	system	system	NOUN
ijpds-4738	243	34	suitability	suitability	NOUN
ijpds-4738	243	35	.	.	PUNCT
ijpds-4738	244	1	in	in	ADP
ijpds-4738	244	2	the	the	DET
ijpds-4738	244	3	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	244	4	industry	industry	NOUN
ijpds-4738	244	5	,	,	PUNCT
ijpds-4738	244	6	validation	validation	NOUN
ijpds-4738	244	7	is	be	AUX
ijpds-4738	244	8	an	an	DET
ijpds-4738	244	9	essential	essential	ADJ
ijpds-4738	244	10	technique	technique	NOUN
ijpds-4738	244	11	that	that	PRON
ijpds-4738	244	12	ensures	ensure	VERB
ijpds-4738	244	13	quality	quality	NOUN
ijpds-4738	244	14	is	be	AUX
ijpds-4738	244	15	included	include	VERB
ijpds-4738	244	16	in	in	ADP
ijpds-4738	244	17	the	the	DET
ijpds-4738	244	18	processes	process	NOUN
ijpds-4738	244	19	that	that	PRON
ijpds-4738	244	20	support	support	VERB
ijpds-4738	244	21	drug	drug	NOUN
ijpds-4738	244	22	development	development	NOUN
ijpds-4738	244	23	and	and	CCONJ
ijpds-4738	244	24	production	production	NOUN
ijpds-4738	244	25	.	.	PUNCT
ijpds-4738	245	1	it	it	PRON
ijpds-4738	245	2	assures	assure	VERB
ijpds-4738	245	3	all	all	DET
ijpds-4738	245	4	parameters	parameter	NOUN
ijpds-4738	245	5	and	and	CCONJ
ijpds-4738	245	6	conducts	conduct	VERB
ijpds-4738	245	7	the	the	DET
ijpds-4738	245	8	phases	phase	NOUN
ijpds-4738	245	9	of	of	ADP
ijpds-4738	245	10	trails	trail	NOUN
ijpds-4738	245	11	.	.	PUNCT
ijpds-4738	246	1	references	reference	NOUN
ijpds-4738	246	2	1	1	NUM
ijpds-4738	246	3	.	.	PUNCT
ijpds-4738	246	4	fda	fda	PROPN
ijpds-4738	246	5	guidance	guidance	NOUN
ijpds-4738	246	6	for	for	ADP
ijpds-4738	246	7	industry	industry	NOUN
ijpds-4738	246	8	.	.	PUNCT
ijpds-4738	247	1	analytical	analytical	ADJ
ijpds-4738	247	2	procedures	procedure	NOUN
ijpds-4738	247	3	and	and	CCONJ
ijpds-4738	247	4	method	method	NOUN
ijpds-4738	247	5	validation	validation	NOUN
ijpds-4738	247	6	,	,	PUNCT
ijpds-4738	247	7	chemistry	chemistry	NOUN
ijpds-4738	247	8	,	,	PUNCT
ijpds-4738	247	9	manufacturing	manufacturing	NOUN
ijpds-4738	247	10	,	,	PUNCT
ijpds-4738	247	11	and	and	CCONJ
ijpds-4738	247	12	controls	control	VERB
ijpds-4738	247	13	documentation	documentation	NOUN
ijpds-4738	247	14	,	,	PUNCT
ijpds-4738	247	15	center	center	NOUN
ijpds-4738	247	16	for	for	ADP
ijpds-4738	247	17	drug	drug	NOUN
ijpds-4738	247	18	evaluation	evaluation	NOUN
ijpds-4738	247	19	and	and	CCONJ
ijpds-4738	247	20	research	research	NOUN
ijpds-4738	247	21	(	(	PUNCT
ijpds-4738	247	22	cder	cder	NOUN
ijpds-4738	247	23	)	)	PUNCT
ijpds-4738	247	24	and	and	CCONJ
ijpds-4738	247	25	center	center	NOUN
ijpds-4738	247	26	for	for	ADP
ijpds-4738	247	27	biologics	biologic	NOUN
ijpds-4738	247	28	evaluation	evaluation	NOUN
ijpds-4738	247	29	and	and	CCONJ
ijpds-4738	247	30	research	research	NOUN
ijpds-4738	247	31	(	(	PUNCT
ijpds-4738	247	32	cber	cber	PROPN
ijpds-4738	247	33	)	)	PUNCT
ijpds-4738	247	34	.	.	PUNCT
ijpds-4738	248	1	2000:234	2000:234	NUM
ijpds-4738	248	2	2	2	NUM
ijpds-4738	248	3	.	.	PUNCT
ijpds-4738	249	1	vander	vander	PROPN
ijpds-4738	249	2	heyden	heyden	PROPN
ijpds-4738	249	3	y	y	PROPN
ijpds-4738	249	4	,	,	PUNCT
ijpds-4738	249	5	nijhuis	nijhuis	ADV
ijpds-4738	249	6	a	a	DET
ijpds-4738	249	7	,	,	PUNCT
ijpds-4738	249	8	smeyers	smeyer	NOUN
ijpds-4738	249	9	-	-	PUNCT
ijpds-4738	249	10	verbeke	verbeke	PROPN
ijpds-4738	249	11	j	j	PROPN
ijpds-4738	249	12	,	,	PUNCT
ijpds-4738	249	13	et	et	PROPN
ijpds-4738	249	14	al	al	PROPN
ijpds-4738	249	15	.	.	PROPN
ijpds-4738	249	16	guidance	guidance	NOUN
ijpds-4738	249	17	for	for	ADP
ijpds-4738	249	18	robustness	robustness	NOUN
ijpds-4738	249	19	/	/	SYM
ijpds-4738	249	20	ruggedness	ruggedness	NOUN
ijpds-4738	249	21	tests	test	NOUN
ijpds-4738	249	22	in	in	ADP
ijpds-4738	249	23	method	method	NOUN
ijpds-4738	249	24	validation	validation	NOUN
ijpds-4738	249	25	.	.	PUNCT
ijpds-4738	250	1	journal	journal	NOUN
ijpds-4738	250	2	of	of	ADP
ijpds-4738	250	3	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	250	4	and	and	CCONJ
ijpds-4738	250	5	biomedical	biomedical	ADJ
ijpds-4738	250	6	analysis	analysis	NOUN
ijpds-4738	250	7	.	.	PUNCT
ijpds-4738	251	1	2001	2001	NUM
ijpds-4738	251	2	;	;	PUNCT
ijpds-4738	251	3	24(56):723	24(56):723	NUM
ijpds-4738	251	4	-	-	SYM
ijpds-4738	251	5	53	53	NUM
ijpds-4738	251	6	.	.	PUNCT
ijpds-4738	252	1	3	3	X
ijpds-4738	252	2	.	.	X
ijpds-4738	252	3	rozet	rozet	PROPN
ijpds-4738	252	4	e	e	PROPN
ijpds-4738	252	5	,	,	PUNCT
ijpds-4738	252	6	lebrun	lebrun	VERB
ijpds-4738	252	7	p	p	NOUN
ijpds-4738	252	8	,	,	PUNCT
ijpds-4738	252	9	hubert	hubert	PROPN
ijpds-4738	252	10	p	p	PROPN
ijpds-4738	252	11	,	,	PUNCT
ijpds-4738	252	12	et	et	PROPN
ijpds-4738	252	13	al	al	PROPN
ijpds-4738	252	14	.	.	PUNCT
ijpds-4738	253	1	design	design	NOUN
ijpds-4738	253	2	spaces	space	NOUN
ijpds-4738	253	3	for	for	ADP
ijpds-4738	253	4	analytical	analytical	ADJ
ijpds-4738	253	5	methods	method	NOUN
ijpds-4738	253	6	.	.	PUNCT
ijpds-4738	254	1	trac	trac	NOUN
ijpds-4738	254	2	trends	trend	NOUN
ijpds-4738	254	3	in	in	ADP
ijpds-4738	254	4	analytical	analytical	ADJ
ijpds-4738	254	5	chemistry	chemistry	NOUN
ijpds-4738	254	6	.	.	PUNCT
ijpds-4738	255	1	2013	2013	NUM
ijpds-4738	255	2	;	;	PUNCT
ijpds-4738	255	3	42:15767	42:15767	NUM
ijpds-4738	255	4	.	.	NOUN
ijpds-4738	256	1	4	4	NUM
ijpds-4738	256	2	.	.	X
ijpds-4738	256	3	chauhan	chauhan	PROPN
ijpds-4738	256	4	a.	a.	PROPN
ijpds-4738	256	5	harti	harti	PROPN
ijpds-4738	256	6	mittu	mittu	PROPN
ijpds-4738	256	7	b	b	PROPN
ijpds-4738	256	8	,	,	PUNCT
ijpds-4738	256	9	chauhan	chauhan	PROPN
ijpds-4738	256	10	p	p	PROPN
ijpds-4738	256	11	(	(	PUNCT
ijpds-4738	256	12	2015	2015	NUM
ijpds-4738	256	13	)	)	PUNCT
ijpds-4738	256	14	analytical	analytical	ADJ
ijpds-4738	256	15	method	method	NOUN
ijpds-4738	256	16	development	development	NOUN
ijpds-4738	256	17	and	and	CCONJ
ijpds-4738	256	18	validation	validation	NOUN
ijpds-4738	256	19	:	:	PUNCT
ijpds-4738	256	20	a	a	DET
ijpds-4738	256	21	concise	concise	ADJ
ijpds-4738	256	22	review	review	NOUN
ijpds-4738	256	23	.	.	PUNCT
ijpds-4738	257	1	j	j	PROPN
ijpds-4738	257	2	anal	anal	ADJ
ijpds-4738	257	3	bioanal	bioanal	ADJ
ijpds-4738	257	4	tech	tech	NOUN
ijpds-4738	257	5	.	.	PUNCT
ijpds-4738	258	1	2015	2015	NUM
ijpds-4738	258	2	;	;	PUNCT
ijpds-4738	258	3	6(233):2	6(233):2	NUM
ijpds-4738	258	4	.	.	NOUN
ijpds-4738	258	5	5	5	NUM
ijpds-4738	258	6	.	.	X
ijpds-4738	258	7	shabir	shabir	PROPN
ijpds-4738	258	8	ga	ga	PROPN
ijpds-4738	258	9	,	,	PUNCT
ijpds-4738	258	10	john	john	PROPN
ijpds-4738	258	11	lough	lough	PROPN
ijpds-4738	258	12	w	w	PROPN
ijpds-4738	258	13	,	,	PUNCT
ijpds-4738	258	14	arain	arain	PROPN
ijpds-4738	258	15	sa	sa	PROPN
ijpds-4738	258	16	,	,	PUNCT
ijpds-4738	258	17	et	et	PROPN
ijpds-4738	258	18	al	al	PROPN
ijpds-4738	258	19	.	.	PUNCT
ijpds-4738	258	20	evaluation	evaluation	NOUN
ijpds-4738	258	21	and	and	CCONJ
ijpds-4738	258	22	application	application	NOUN
ijpds-4738	258	23	of	of	ADP
ijpds-4738	258	24	best	good	ADJ
ijpds-4738	258	25	practice	practice	NOUN
ijpds-4738	258	26	in	in	ADP
ijpds-4738	258	27	analytical	analytical	ADJ
ijpds-4738	258	28	method	method	NOUN
ijpds-4738	258	29	validation	validation	NOUN
ijpds-4738	258	30	.	.	PUNCT
ijpds-4738	259	1	journal	journal	NOUN
ijpds-4738	259	2	of	of	ADP
ijpds-4738	259	3	liquid	liquid	ADJ
ijpds-4738	259	4	chromatography	chromatography	NOUN
ijpds-4738	259	5	&	&	CCONJ
ijpds-4738	259	6	related	related	ADJ
ijpds-4738	259	7	technologies	technology	NOUN
ijpds-4738	259	8	.	.	PUNCT
ijpds-4738	260	1	2007	2007	NUM
ijpds-4738	260	2	;	;	PUNCT
ijpds-4738	260	3	30(3):311	30(3):311	NUM
ijpds-4738	260	4	-	-	SYM
ijpds-4738	260	5	33	33	NUM
ijpds-4738	260	6	.	.	NOUN
ijpds-4738	260	7	6	6	NUM
ijpds-4738	260	8	.	.	PUNCT
ijpds-4738	261	1	sharma	sharma	PROPN
ijpds-4738	261	2	s	s	PROPN
ijpds-4738	261	3	,	,	PUNCT
ijpds-4738	261	4	goyal	goyal	PROPN
ijpds-4738	261	5	s	s	PROPN
ijpds-4738	261	6	,	,	PUNCT
ijpds-4738	261	7	chauhan	chauhan	PROPN
ijpds-4738	261	8	k.	k.	PROPN
ijpds-4738	262	1	a	a	DET
ijpds-4738	262	2	review	review	NOUN
ijpds-4738	262	3	on	on	ADP
ijpds-4738	262	4	analytical	analytical	ADJ
ijpds-4738	262	5	method	method	NOUN
ijpds-4738	262	6	development	development	NOUN
ijpds-4738	262	7	and	and	CCONJ
ijpds-4738	262	8	validation	validation	NOUN
ijpds-4738	262	9	.	.	PUNCT
ijpds-4738	263	1	international	international	ADJ
ijpds-4738	263	2	journal	journal	NOUN
ijpds-4738	263	3	of	of	ADP
ijpds-4738	263	4	applied	apply	VERB
ijpds-4738	263	5	pharmaceutics	pharmaceutic	NOUN
ijpds-4738	263	6	.	.	PUNCT
ijpds-4738	263	7	2018	2018	NUM
ijpds-4738	263	8	;	;	PUNCT
ijpds-4738	263	9	10(6):8	10(6):8	NUM
ijpds-4738	263	10	-	-	SYM
ijpds-4738	263	11	15	15	NUM
ijpds-4738	263	12	.	.	NOUN
ijpds-4738	264	1	7	7	X
ijpds-4738	264	2	.	.	X
ijpds-4738	264	3	castelino	castelino	PROPN
ijpds-4738	264	4	lj	lj	PROPN
ijpds-4738	264	5	,	,	PUNCT
ijpds-4738	264	6	narayanan	narayanan	PROPN
ijpds-4738	264	7	va	va	PROPN
ijpds-4738	264	8	,	,	PUNCT
ijpds-4738	264	9	fernandes	fernandes	PROPN
ijpds-4738	264	10	sd	sd	PROPN
ijpds-4738	264	11	,	,	PUNCT
ijpds-4738	264	12	et	et	PROPN
ijpds-4738	264	13	al	al	PROPN
ijpds-4738	264	14	.	.	PROPN
ijpds-4738	265	1	good	good	ADJ
ijpds-4738	265	2	clinical	clinical	ADJ
ijpds-4738	265	3	practices	practice	NOUN
ijpds-4738	265	4	:	:	PUNCT
ijpds-4738	265	5	an	an	DET
ijpds-4738	265	6	indian	indian	ADJ
ijpds-4738	265	7	perspective	perspective	NOUN
ijpds-4738	265	8	.	.	PUNCT
ijpds-4738	266	1	research	research	NOUN
ijpds-4738	266	2	journal	journal	PROPN
ijpds-4738	266	3	of	of	ADP
ijpds-4738	266	4	pharmacy	pharmacy	NOUN
ijpds-4738	266	5	and	and	CCONJ
ijpds-4738	266	6	technology	technology	NOUN
ijpds-4738	266	7	.	.	PUNCT
ijpds-4738	267	1	2018	2018	NUM
ijpds-4738	267	2	;	;	PUNCT
ijpds-4738	268	1	11(7):3209	11(7):3209	NUM
ijpds-4738	268	2	-	-	SYM
ijpds-4738	268	3	15	15	NUM
ijpds-4738	268	4	.	.	NOUN
ijpds-4738	268	5	8	8	NUM
ijpds-4738	268	6	.	.	PUNCT
ijpds-4738	269	1	kavittha	kavittha	PROPN
ijpds-4738	269	2	ky	ky	PROPN
ijpds-4738	269	3	,	,	PUNCT
ijpds-4738	269	4	geetha	geetha	PROPN
ijpds-4738	269	5	g	g	PROPN
ijpds-4738	269	6	,	,	PUNCT
ijpds-4738	269	7	venkatnarayanan	venkatnarayanan	PROPN
ijpds-4738	269	8	r.	r.	PROPN
ijpds-4738	269	9	development	development	PROPN
ijpds-4738	269	10	and	and	CCONJ
ijpds-4738	269	11	validation	validation	NOUN
ijpds-4738	269	12	of	of	ADP
ijpds-4738	269	13	liquid	liquid	ADJ
ijpds-4738	269	14	chromatographic	chromatographic	ADJ
ijpds-4738	269	15	methods	method	NOUN
ijpds-4738	269	16	for	for	ADP
ijpds-4738	269	17	the	the	DET
ijpds-4738	269	18	estimation	estimation	NOUN
ijpds-4738	269	19	of	of	ADP
ijpds-4738	269	20	drugs	drug	NOUN
ijpds-4738	269	21	in	in	ADP
ijpds-4738	269	22	multi	multi	ADJ
ijpds-4738	269	23	-	-	ADJ
ijpds-4738	269	24	component	component	ADJ
ijpds-4738	269	25	dosage	dosage	NOUN
ijpds-4738	269	26	forms	form	NOUN
ijpds-4738	269	27	.	.	PUNCT
ijpds-4738	270	1	pharmacie	pharmacie	PROPN
ijpds-4738	270	2	globale	globale	PROPN
ijpds-4738	270	3	.	.	PUNCT
ijpds-4738	271	1	2012	2012	NUM
ijpds-4738	271	2	;	;	PUNCT
ijpds-4738	272	1	3(11):1	3(11):1	NUM
ijpds-4738	272	2	.	.	NOUN
ijpds-4738	272	3	9	9	NUM
ijpds-4738	272	4	.	.	X
ijpds-4738	272	5	sankar	sankar	NOUN
ijpds-4738	272	6	rs	rs	PROPN
ijpds-4738	272	7	.	.	PUNCT
ijpds-4738	273	1	text	text	NOUN
ijpds-4738	273	2	book	book	NOUN
ijpds-4738	273	3	of	of	ADP
ijpds-4738	273	4	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	273	5	analysis	analysis	NOUN
ijpds-4738	273	6	.	.	PUNCT
ijpds-4738	274	1	rx	rx	VERB
ijpds-4738	274	2	publications	publication	NOUN
ijpds-4738	274	3	;	;	PUNCT
ijpds-4738	274	4	2010	2010	NUM
ijpds-4738	274	5	.	.	PUNCT
ijpds-4738	275	1	10	10	NUM
ijpds-4738	275	2	.	.	PUNCT
ijpds-4738	275	3	shu	shu	PROPN
ijpds-4738	275	4	yz	yz	PROPN
ijpds-4738	275	5	.	.	PUNCT
ijpds-4738	276	1	recent	recent	ADJ
ijpds-4738	276	2	natural	natural	ADJ
ijpds-4738	276	3	products	product	NOUN
ijpds-4738	276	4	based	base	VERB
ijpds-4738	276	5	drug	drug	NOUN
ijpds-4738	276	6	development	development	NOUN
ijpds-4738	276	7	:	:	PUNCT
ijpds-4738	276	8	a	a	DET
ijpds-4738	276	9	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	276	10	industry	industry	NOUN
ijpds-4738	276	11	perspective	perspective	NOUN
ijpds-4738	276	12	.	.	PUNCT
ijpds-4738	277	1	journal	journal	NOUN
ijpds-4738	277	2	of	of	ADP
ijpds-4738	277	3	natural	natural	ADJ
ijpds-4738	277	4	products	product	NOUN
ijpds-4738	277	5	.	.	PUNCT
ijpds-4738	278	1	1998	1998	NUM
ijpds-4738	278	2	;	;	PUNCT
ijpds-4738	278	3	61(8):1053	61(8):1053	NUM
ijpds-4738	278	4	-	-	SYM
ijpds-4738	278	5	71	71	NUM
ijpds-4738	278	6	.	.	PUNCT
ijpds-4738	279	1	11	11	NUM
ijpds-4738	279	2	.	.	PUNCT
ijpds-4738	280	1	chin	chin	PROPN
ijpds-4738	280	2	ww	ww	PROPN
ijpds-4738	280	3	,	,	PUNCT
ijpds-4738	280	4	parmentier	parmentier	PROPN
ijpds-4738	280	5	j	j	PROPN
ijpds-4738	280	6	,	,	PUNCT
ijpds-4738	280	7	widzinski	widzinski	PROPN
ijpds-4738	280	8	m	m	PROPN
ijpds-4738	280	9	,	,	PUNCT
ijpds-4738	280	10	et	et	PROPN
ijpds-4738	280	11	al	al	PROPN
ijpds-4738	280	12	.	.	PUNCT
ijpds-4738	281	1	a	a	DET
ijpds-4738	281	2	brief	brief	ADJ
ijpds-4738	281	3	literature	literature	NOUN
ijpds-4738	281	4	and	and	CCONJ
ijpds-4738	281	5	patent	patent	NOUN
ijpds-4738	281	6	review	review	NOUN
ijpds-4738	281	7	of	of	ADP
ijpds-4738	281	8	nanosuspensions	nanosuspension	NOUN
ijpds-4738	281	9	to	to	ADP
ijpds-4738	281	10	a	a	DET
ijpds-4738	281	11	final	final	ADJ
ijpds-4738	281	12	drug	drug	NOUN
ijpds-4738	281	13	product	product	NOUN
ijpds-4738	281	14	.	.	PUNCT
ijpds-4738	282	1	journal	journal	NOUN
ijpds-4738	282	2	of	of	ADP
ijpds-4738	282	3	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	282	4	sciences	science	NOUN
ijpds-4738	282	5	.	.	PUNCT
ijpds-4738	283	1	2014	2014	NUM
ijpds-4738	283	2	;	;	PUNCT
ijpds-4738	284	1	103(10):2980	103(10):2980	PROPN
ijpds-4738	284	2	-	-	SYM
ijpds-4738	284	3	99	99	NUM
ijpds-4738	284	4	.	.	PUNCT
ijpds-4738	284	5	12	12	NUM
ijpds-4738	284	6	.	.	PUNCT
ijpds-4738	285	1	s.	s.	PROPN
ijpds-4738	285	2	sood	sood	PROPN
ijpds-4738	285	3	,	,	PUNCT
ijpds-4738	285	4	r.	r.	PROPN
ijpds-4738	285	5	bala	bala	PROPN
ijpds-4738	285	6	,	,	PUNCT
ijpds-4738	285	7	n.s	n.s	PROPN
ijpds-4738	285	8	.	.	PROPN
ijpds-4738	285	9	gill	gill	PROPN
ijpds-4738	285	10	,	,	PUNCT
ijpds-4738	285	11	method	method	NOUN
ijpds-4738	285	12	development	development	NOUN
ijpds-4738	285	13	and	and	CCONJ
ijpds-4738	285	14	validation	validation	NOUN
ijpds-4738	285	15	using	use	VERB
ijpds-4738	285	16	hplc	hplc	NOUN
ijpds-4738	285	17	technique	technique	NOUN
ijpds-4738	285	18	–	–	PUNCT
ijpds-4738	285	19	a	a	DET
ijpds-4738	285	20	review	review	NOUN
ijpds-4738	285	21	,	,	PUNCT
ijpds-4738	285	22	journal	journal	NOUN
ijpds-4738	285	23	of	of	ADP
ijpds-4738	285	24	drug	drug	NOUN
ijpds-4738	285	25	discovery	discovery	NOUN
ijpds-4738	285	26	and	and	CCONJ
ijpds-4738	285	27	therapeutics	therapeutic	NOUN
ijpds-4738	285	28	2	2	NUM
ijpds-4738	285	29	(	(	PUNCT
ijpds-4738	285	30	22	22	NUM
ijpds-4738	285	31	)	)	PUNCT
ijpds-4738	285	32	2014	2014	NUM
ijpds-4738	285	33	,	,	PUNCT
ijpds-4738	285	34	1824	1824	NUM
ijpds-4738	285	35	.	.	PUNCT
ijpds-4738	286	1	13	13	NUM
ijpds-4738	286	2	.	.	PUNCT
ijpds-4738	286	3	charde	charde	PROPN
ijpds-4738	286	4	ms	ms	PROPN
ijpds-4738	286	5	,	,	PUNCT
ijpds-4738	286	6	welankiwar	welankiwar	ADV
ijpds-4738	286	7	as	as	ADP
ijpds-4738	286	8	,	,	PUNCT
ijpds-4738	286	9	kumar	kumar	PROPN
ijpds-4738	286	10	j.	j.	PROPN
ijpds-4738	286	11	method	method	PROPN
ijpds-4738	286	12	development	development	NOUN
ijpds-4738	286	13	by	by	ADP
ijpds-4738	286	14	liquid	liquid	ADJ
ijpds-4738	286	15	chromatography	chromatography	NOUN
ijpds-4738	286	16	with	with	ADP
ijpds-4738	286	17	validation	validation	NOUN
ijpds-4738	286	18	.	.	PUNCT
ijpds-4738	287	1	international	international	ADJ
ijpds-4738	287	2	journal	journal	PROPN
ijpds-4738	287	3	of	of	ADP
ijpds-4738	287	4	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	287	5	chemistry	chemistry	NOUN
ijpds-4738	287	6	.	.	PUNCT
ijpds-4738	288	1	2014	2014	NUM
ijpds-4738	288	2	;	;	PUNCT
ijpds-4738	288	3	4(02):57	4(02):57	NOUN
ijpds-4738	288	4	-	-	PUNCT
ijpds-4738	288	5	61	61	NUM
ijpds-4738	288	6	.	.	PUNCT
ijpds-4738	289	1	14	14	NUM
ijpds-4738	289	2	.	.	PUNCT
ijpds-4738	290	1	isane	isane	PROPN
ijpds-4738	290	2	sp	sp	PROPN
ijpds-4738	290	3	,	,	PUNCT
ijpds-4738	290	4	waghmare	waghmare	NOUN
ijpds-4738	290	5	sa	sa	PROPN
ijpds-4738	290	6	,	,	PUNCT
ijpds-4738	290	7	kamble	kamble	PROPN
ijpds-4738	290	8	hv	hv	PROPN
ijpds-4738	290	9	.	.	PUNCT
ijpds-4738	291	1	a	a	DET
ijpds-4738	291	2	review	review	NOUN
ijpds-4738	291	3	on	on	ADP
ijpds-4738	291	4	method	method	NOUN
ijpds-4738	291	5	development	development	NOUN
ijpds-4738	291	6	,	,	PUNCT
ijpds-4738	291	7	validation	validation	NOUN
ijpds-4738	291	8	,	,	PUNCT
ijpds-4738	291	9	optimization	optimization	NOUN
ijpds-4738	291	10	and	and	CCONJ
ijpds-4738	291	11	applications	application	NOUN
ijpds-4738	291	12	of	of	ADP
ijpds-4738	291	13	hplc	hplc	NOUN
ijpds-4738	291	14	.	.	PUNCT
ijpds-4738	292	1	15	15	NUM
ijpds-4738	292	2	.	.	X
ijpds-4738	292	3	md	md	PROPN
ijpds-4738	292	4	sabir	sabir	PROPN
ijpds-4738	292	5	a	a	PROPN
ijpds-4738	292	6	,	,	PUNCT
ijpds-4738	292	7	moloy	moloy	PROPN
ijpds-4738	292	8	m	m	PROPN
ijpds-4738	292	9	,	,	PUNCT
ijpds-4738	292	10	parminder	parminder	ADP
ijpds-4738	292	11	bs	bs	PROPN
ijpds-4738	292	12	.	.	PUNCT
ijpds-4738	293	1	hplc	hplc	PROPN
ijpds-4738	293	2	method	method	PROPN
ijpds-4738	293	3	development	development	NOUN
ijpds-4738	293	4	and	and	CCONJ
ijpds-4738	293	5	validatıon	validatıon	ADV
ijpds-4738	293	6	:	:	PUNCT
ijpds-4738	293	7	a	a	DET
ijpds-4738	293	8	review	review	NOUN
ijpds-4738	293	9	.	.	PUNCT
ijpds-4738	294	1	int	int	NOUN
ijpds-4738	294	2	res	re	NOUN
ijpds-4738	294	3	j	j	PROPN
ijpds-4738	294	4	pharm	pharm	PROPN
ijpds-4738	294	5	.	.	PUNCT
ijpds-4738	295	1	2013	2013	NUM
ijpds-4738	295	2	;	;	PUNCT
ijpds-4738	295	3	4:39	4:39	NUM
ijpds-4738	295	4	-	-	SYM
ijpds-4738	295	5	46	46	NUM
ijpds-4738	295	6	.	.	PUNCT
ijpds-4738	296	1	16	16	NUM
ijpds-4738	296	2	.	.	PUNCT
ijpds-4738	297	1	chandrul	chandrul	PROPN
ijpds-4738	297	2	kaushal	kaushal	PROPN
ijpds-4738	297	3	k	k	PROPN
ijpds-4738	297	4	,	,	PUNCT
ijpds-4738	297	5	srivastava	srivastava	PROPN
ijpds-4738	297	6	b.	b.	PROPN
ijpds-4738	297	7	a	a	DET
ijpds-4738	297	8	process	process	NOUN
ijpds-4738	297	9	of	of	ADP
ijpds-4738	297	10	method	method	NOUN
ijpds-4738	297	11	development	development	NOUN
ijpds-4738	297	12	:	:	PUNCT
ijpds-4738	297	13	a	a	DET
ijpds-4738	297	14	chromatographic	chromatographic	ADJ
ijpds-4738	297	15	approach	approach	NOUN
ijpds-4738	297	16	.	.	PUNCT
ijpds-4738	298	1	j.	j.	PROPN
ijpds-4738	298	2	chem	chem	PROPN
ijpds-4738	298	3	.	.	PUNCT
ijpds-4738	299	1	pharm	pharm	PROPN
ijpds-4738	299	2	.	.	PUNCT
ijpds-4738	300	1	res	re	NOUN
ijpds-4738	300	2	.	.	PUNCT
ijpds-4738	301	1	2010	2010	NUM
ijpds-4738	301	2	;	;	PUNCT
ijpds-4738	301	3	2(2):519	2(2):519	NUM
ijpds-4738	301	4	-	-	SYM
ijpds-4738	301	5	45	45	NUM
ijpds-4738	301	6	.	.	PUNCT
ijpds-4738	302	1	17	17	NUM
ijpds-4738	302	2	.	.	PUNCT
ijpds-4738	303	1	lindholm	lindholm	PROPN
ijpds-4738	303	2	j.	j.	PROPN
ijpds-4738	303	3	development	development	PROPN
ijpds-4738	303	4	and	and	CCONJ
ijpds-4738	303	5	validation	validation	NOUN
ijpds-4738	303	6	of	of	ADP
ijpds-4738	303	7	hplc	hplc	NOUN
ijpds-4738	303	8	methods	method	NOUN
ijpds-4738	303	9	for	for	ADP
ijpds-4738	303	10	analytical	analytical	ADJ
ijpds-4738	303	11	and	and	CCONJ
ijpds-4738	303	12	preparative	preparative	ADJ
ijpds-4738	303	13	purposes	purpose	NOUN
ijpds-4738	303	14	(	(	PUNCT
ijpds-4738	303	15	doctoral	doctoral	ADJ
ijpds-4738	303	16	dissertation	dissertation	NOUN
ijpds-4738	303	17	,	,	PUNCT
ijpds-4738	303	18	acta	acta	PROPN
ijpds-4738	303	19	universitatis	universitatis	NOUN
ijpds-4738	303	20	upsaliensis	upsaliensis	NOUN
ijpds-4738	303	21	)	)	PUNCT
ijpds-4738	303	22	.	.	PUNCT
ijpds-4738	304	1	18	18	NUM
ijpds-4738	304	2	.	.	X
ijpds-4738	305	1	snyder	snyder	PROPN
ijpds-4738	305	2	lr	lr	PROPN
ijpds-4738	305	3	,	,	PUNCT
ijpds-4738	305	4	kirkland	kirkland	PROPN
ijpds-4738	305	5	jj	jj	PROPN
ijpds-4738	305	6	,	,	PUNCT
ijpds-4738	305	7	glajch	glajch	PROPN
ijpds-4738	305	8	jl	jl	PROPN
ijpds-4738	305	9	.	.	PUNCT
ijpds-4738	306	1	practical	practical	ADJ
ijpds-4738	306	2	hplc	hplc	NOUN
ijpds-4738	306	3	method	method	NOUN
ijpds-4738	306	4	development	development	NOUN
ijpds-4738	306	5	.	.	PUNCT
ijpds-4738	307	1	john	john	PROPN
ijpds-4738	307	2	wiley	wiley	PROPN
ijpds-4738	307	3	&	&	CCONJ
ijpds-4738	307	4	sons	son	NOUN
ijpds-4738	307	5	;	;	PUNCT
ijpds-4738	307	6	2012	2012	NUM
ijpds-4738	307	7	dec	dec	NOUN
ijpds-4738	307	8	3	3	NUM
ijpds-4738	307	9	.	.	PROPN
ijpds-4738	307	10	19	19	NUM
ijpds-4738	307	11	.	.	PUNCT
ijpds-4738	308	1	dean	dean	PROPN
ijpds-4738	308	2	ja	ja	PROPN
ijpds-4738	308	3	.	.	PROPN
ijpds-4738	309	1	analytical	analytical	ADJ
ijpds-4738	309	2	chemistry	chemistry	NOUN
ijpds-4738	309	3	handbook	handbook	NOUN
ijpds-4738	309	4	.	.	PUNCT
ijpds-4738	310	1	(	(	PUNCT
ijpds-4738	310	2	no	no	DET
ijpds-4738	310	3	title	title	NOUN
ijpds-4738	310	4	)	)	PUNCT
ijpds-4738	310	5	.	.	PUNCT
ijpds-4738	311	1	1995	1995	NUM
ijpds-4738	311	2	apr	apr	NOUN
ijpds-4738	311	3	.	.	PROPN
ijpds-4738	311	4	20	20	NUM
ijpds-4738	311	5	.	.	PUNCT
ijpds-4738	311	6	troubleshooting	troubleshoot	VERB
ijpds-4738	311	7	l.	l.	PROPN
ijpds-4738	311	8	stability	stability	NOUN
ijpds-4738	311	9	-	-	PUNCT
ijpds-4738	311	10	indicating	indicate	VERB
ijpds-4738	311	11	assays	assay	NOUN
ijpds-4738	311	12	.	.	PUNCT
ijpds-4738	312	1	lc•	lc•	PROPN
ijpds-4738	312	2	gc	gc	PROPN
ijpds-4738	312	3	europe	europe	PROPN
ijpds-4738	312	4	.	.	PUNCT
ijpds-4738	313	1	2002	2002	NUM
ijpds-4738	313	2	may	may	AUX
ijpds-4738	313	3	:	:	PUNCT
ijpds-4738	313	4	274	274	NUM
ijpds-4738	313	5	.	.	X
ijpds-4738	313	6	21	21	NUM
ijpds-4738	313	7	.	.	PUNCT
ijpds-4738	314	1	pirok	pirok	PROPN
ijpds-4738	314	2	bw	bw	PROPN
ijpds-4738	314	3	,	,	PUNCT
ijpds-4738	314	4	gargano	gargano	PROPN
ijpds-4738	314	5	af	af	PROPN
ijpds-4738	314	6	,	,	PUNCT
ijpds-4738	314	7	schoenmakers	schoenmaker	VERB
ijpds-4738	314	8	pj	pj	PROPN
ijpds-4738	314	9	.	.	PUNCT
ijpds-4738	315	1	optimizing	optimize	VERB
ijpds-4738	315	2	separations	separation	NOUN
ijpds-4738	315	3	in	in	ADP
ijpds-4738	315	4	online	online	ADJ
ijpds-4738	315	5	comprehensive	comprehensive	ADJ
ijpds-4738	315	6	two‐dimensional	two‐dimensional	ADJ
ijpds-4738	315	7	liquid	liquid	ADJ
ijpds-4738	315	8	chromatography	chromatography	NOUN
ijpds-4738	315	9	.	.	PUNCT
ijpds-4738	316	1	journal	journal	PROPN
ijpds-4738	316	2	of	of	ADP
ijpds-4738	316	3	separation	separation	NOUN
ijpds-4738	316	4	science	science	NOUN
ijpds-4738	316	5	.	.	PUNCT
ijpds-4738	317	1	2018	2018	NUM
ijpds-4738	317	2	;	;	PUNCT
ijpds-4738	318	1	41(1):6898	41(1):6898	PROPN
ijpds-4738	318	2	.	.	PUNCT
ijpds-4738	319	1	22	22	NUM
ijpds-4738	319	2	.	.	PUNCT
ijpds-4738	320	1	hong	hong	PROPN
ijpds-4738	320	2	dd	dd	PROPN
ijpds-4738	320	3	,	,	PUNCT
ijpds-4738	320	4	shah	shah	PROPN
ijpds-4738	320	5	m.	m.	NOUN
ijpds-4738	320	6	development	development	NOUN
ijpds-4738	320	7	and	and	CCONJ
ijpds-4738	320	8	validation	validation	NOUN
ijpds-4738	320	9	of	of	ADP
ijpds-4738	320	10	hplc	hplc	NOUN
ijpds-4738	320	11	stability	stability	NOUN
ijpds-4738	320	12	-	-	PUNCT
ijpds-4738	320	13	indicating	indicate	VERB
ijpds-4738	320	14	assays	assay	NOUN
ijpds-4738	320	15	.	.	PUNCT
ijpds-4738	321	1	drugs	drug	NOUN
ijpds-4738	321	2	and	and	CCONJ
ijpds-4738	321	3	the	the	DET
ijpds-4738	321	4	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	321	5	sciences	science	NOUN
ijpds-4738	321	6	.	.	PUNCT
ijpds-4738	321	7	2000	2000	NUM
ijpds-4738	321	8	;	;	PUNCT
ijpds-4738	321	9	107:329	107:329	PROPN
ijpds-4738	321	10	-	-	SYM
ijpds-4738	321	11	84	84	NUM
ijpds-4738	321	12	.	.	PUNCT
ijpds-4738	322	1	23	23	NUM
ijpds-4738	322	2	.	.	PUNCT
ijpds-4738	322	3	gassmann	gassmann	PROPN
ijpds-4738	322	4	o	o	PROPN
ijpds-4738	322	5	,	,	PUNCT
ijpds-4738	322	6	reepmeyer	reepmeyer	PROPN
ijpds-4738	322	7	g	g	PROPN
ijpds-4738	322	8	,	,	PUNCT
ijpds-4738	322	9	von	von	PROPN
ijpds-4738	322	10	zedtwitz	zedtwitz	PROPN
ijpds-4738	322	11	m.	m.	PROPN
ijpds-4738	322	12	leading	lead	VERB
ijpds-4738	322	13	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	322	14	innovation	innovation	NOUN
ijpds-4738	322	15	.	.	PUNCT
ijpds-4738	323	1	berlin	berlin	ADJ
ijpds-4738	323	2	:	:	PUNCT
ijpds-4738	323	3	springer	springer	NOUN
ijpds-4738	323	4	.	.	PUNCT
ijpds-4738	324	1	https://doi	https://doi	PROPN
ijpds-4738	324	2	.	.	PUNCT
ijpds-4738	324	3	org/10	org/10	PROPN
ijpds-4738	324	4	.	.	PROPN
ijpds-4738	324	5	2008	2008	NUM
ijpds-4738	324	6	;	;	PUNCT
ijpds-4738	324	7	1007:978	1007:978	NUM
ijpds-4738	324	8	-	-	SYM
ijpds-4738	324	9	3	3	NUM
ijpds-4738	324	10	.	.	PUNCT
ijpds-4738	324	11	patil	patil	PROPN
ijpds-4738	324	12	et	et	PROPN
ijpds-4738	324	13	al	al	PROPN
ijpds-4738	324	14	.	.	PROPN
ijpds-4738	325	1	analytical	analytical	ADJ
ijpds-4738	325	2	method	method	PROPN
ijpds-4738	325	3	development	development	NOUN
ijpds-4738	325	4	and	and	CCONJ
ijpds-4738	325	5	validation	validation	NOUN
ijpds-4738	325	6	online	online	ADJ
ijpds-4738	325	7	first	first	PROPN
ijpds-4738	325	8	indian	indian	PROPN
ijpds-4738	325	9	j	j	PROPN
ijpds-4738	325	10	pharm	pharm	PROPN
ijpds-4738	325	11	drug	drug	PROPN
ijpds-4738	325	12	studies	study	NOUN
ijpds-4738	325	13	|	|	ADV
ijpds-4738	325	14	7	7	NUM
ijpds-4738	325	15	24	24	NUM
ijpds-4738	325	16	.	.	PUNCT
ijpds-4738	326	1	br	br	PROPN
ijpds-4738	326	2	.	.	PUNCT
ijpds-4738	327	1	jay	jay	PROPN
ijpds-4738	327	2	,	,	PUNCT
ijpds-4738	327	3	j.	j.	PROPN
ijpds-4738	327	4	kelvin	kelvin	PROPN
ijpds-4738	327	5	,	,	PUNCT
ijpds-4738	327	6	and	and	CCONJ
ijpds-4738	327	7	b.	b.	PROPN
ijpds-4738	327	8	pierre	pierre	PROPN
ijpds-4738	327	9	,	,	PUNCT
ijpds-4738	327	10	understanding	understanding	NOUN
ijpds-4738	327	11	and	and	CCONJ
ijpds-4738	327	12	implementing	implement	VERB
ijpds-4738	327	13	efficient	efficient	ADJ
ijpds-4738	327	14	analytical	analytical	ADJ
ijpds-4738	327	15	methods	method	NOUN
ijpds-4738	327	16	development	development	NOUN
ijpds-4738	327	17	and	and	CCONJ
ijpds-4738	327	18	validation	validation	NOUN
ijpds-4738	327	19	,	,	PUNCT
ijpds-4738	327	20	2003	2003	NUM
ijpds-4738	327	21	.	.	PUNCT
ijpds-4738	328	1	25	25	NUM
ijpds-4738	328	2	.	.	PUNCT
ijpds-4738	329	1	huber	huber	PROPN
ijpds-4738	329	2	l.	l.	PROPN
ijpds-4738	329	3	validation	validation	PROPN
ijpds-4738	329	4	of	of	ADP
ijpds-4738	329	5	analytical	analytical	ADJ
ijpds-4738	329	6	methods	method	NOUN
ijpds-4738	329	7	and	and	CCONJ
ijpds-4738	329	8	processes	process	NOUN
ijpds-4738	329	9	.	.	PUNCT
ijpds-4738	330	1	inpharmaceutical	inpharmaceutical	ADJ
ijpds-4738	330	2	process	process	NOUN
ijpds-4738	330	3	validation	validation	NOUN
ijpds-4738	330	4	2003	2003	NUM
ijpds-4738	330	5	mar	mar	PROPN
ijpds-4738	330	6	27	27	NUM
ijpds-4738	330	7	(	(	PUNCT
ijpds-4738	330	8	pp	pp	ADJ
ijpds-4738	330	9	.	.	PUNCT
ijpds-4738	331	1	550	550	NUM
ijpds-4738	331	2	-	-	SYM
ijpds-4738	331	3	567	567	NUM
ijpds-4738	331	4	)	)	PUNCT
ijpds-4738	331	5	.	.	PUNCT
ijpds-4738	332	1	crc	crc	PROPN
ijpds-4738	332	2	press	press	PROPN
ijpds-4738	332	3	.	.	PUNCT
ijpds-4738	333	1	26	26	NUM
ijpds-4738	333	2	.	.	PUNCT
ijpds-4738	334	1	mokhtar	mokhtar	PROPN
ijpds-4738	334	2	hi	hi	PROPN
ijpds-4738	334	3	,	,	PUNCT
ijpds-4738	334	4	abdel	abdel	PROPN
ijpds-4738	334	5	-	-	PUNCT
ijpds-4738	334	6	salam	salam	PROPN
ijpds-4738	334	7	ra	ra	PROPN
ijpds-4738	334	8	,	,	PUNCT
ijpds-4738	334	9	hadad	hadad	PROPN
ijpds-4738	334	10	gm	gm	PROPN
ijpds-4738	334	11	.	.	PUNCT
ijpds-4738	335	1	development	development	NOUN
ijpds-4738	335	2	of	of	ADP
ijpds-4738	335	3	a	a	DET
ijpds-4738	335	4	fast	fast	ADJ
ijpds-4738	335	5	high	high	ADJ
ijpds-4738	335	6	performance	performance	NOUN
ijpds-4738	335	7	liquid	liquid	ADJ
ijpds-4738	335	8	chromatographic	chromatographic	ADJ
ijpds-4738	335	9	screening	screening	NOUN
ijpds-4738	335	10	system	system	NOUN
ijpds-4738	335	11	for	for	ADP
ijpds-4738	335	12	eight	eight	NUM
ijpds-4738	335	13	antidiabetic	antidiabetic	ADJ
ijpds-4738	335	14	drugs	drug	NOUN
ijpds-4738	335	15	by	by	ADP
ijpds-4738	335	16	an	an	DET
ijpds-4738	335	17	improved	improved	ADJ
ijpds-4738	335	18	methodology	methodology	NOUN
ijpds-4738	335	19	of	of	ADP
ijpds-4738	335	20	insilico	insilico	NOUN
ijpds-4738	335	21	robustness	robustness	NOUN
ijpds-4738	335	22	simulation	simulation	NOUN
ijpds-4738	335	23	.	.	PUNCT
ijpds-4738	336	1	journal	journal	PROPN
ijpds-4738	336	2	of	of	ADP
ijpds-4738	336	3	chromatography	chromatography	NOUN
ijpds-4738	336	4	a.	a.	NOUN
ijpds-4738	336	5	2015	2015	NUM
ijpds-4738	336	6	;	;	PUNCT
ijpds-4738	336	7	1399:32	1399:32	NUM
ijpds-4738	336	8	-	-	SYM
ijpds-4738	336	9	44	44	NUM
ijpds-4738	336	10	.	.	PUNCT
ijpds-4738	336	11	27	27	NUM
ijpds-4738	336	12	.	.	PUNCT
ijpds-4738	337	1	guidance	guidance	VERB
ijpds-4738	337	2	r.	r.	NOUN
ijpds-4738	337	3	validation	validation	NOUN
ijpds-4738	337	4	of	of	ADP
ijpds-4738	337	5	chromatographic	chromatographic	ADJ
ijpds-4738	337	6	methods	method	NOUN
ijpds-4738	337	7	.	.	PUNCT
ijpds-4738	338	1	center	center	NOUN
ijpds-4738	338	2	for	for	ADP
ijpds-4738	338	3	drug	drug	NOUN
ijpds-4738	338	4	evaluation	evaluation	NOUN
ijpds-4738	338	5	and	and	CCONJ
ijpds-4738	338	6	research	research	NOUN
ijpds-4738	338	7	(	(	PUNCT
ijpds-4738	338	8	cder	cder	NOUN
ijpds-4738	338	9	)	)	PUNCT
ijpds-4738	338	10	,	,	PUNCT
ijpds-4738	338	11	washington	washington	PROPN
ijpds-4738	338	12	.	.	PROPN
ijpds-4738	338	13	1994	1994	NUM
ijpds-4738	338	14	;	;	PUNCT
ijpds-4738	338	15	2	2	NUM
ijpds-4738	338	16	.	.	NOUN
ijpds-4738	338	17	28	28	NUM
ijpds-4738	338	18	.	.	X
ijpds-4738	339	1	ich	ich	NOUN
ijpds-4738	339	2	-	-	PUNCT
ijpds-4738	339	3	q2b	q2b	PROPN
ijpds-4738	339	4	.	.	PUNCT
ijpds-4738	340	1	international	international	ADJ
ijpds-4738	340	2	conference	conference	NOUN
ijpds-4738	340	3	on	on	ADP
ijpds-4738	340	4	harmonization	harmonization	NOUN
ijpds-4738	340	5	(	(	PUNCT
ijpds-4738	340	6	ich	ich	NOUN
ijpds-4738	340	7	)	)	PUNCT
ijpds-4738	340	8	of	of	ADP
ijpds-4738	340	9	technical	technical	ADJ
ijpds-4738	340	10	requirements	requirement	NOUN
ijpds-4738	340	11	for	for	ADP
ijpds-4738	340	12	the	the	DET
ijpds-4738	340	13	registration	registration	NOUN
ijpds-4738	340	14	of	of	ADP
ijpds-4738	340	15	pharmaceuticals	pharmaceutical	NOUN
ijpds-4738	340	16	for	for	ADP
ijpds-4738	340	17	human	human	ADJ
ijpds-4738	340	18	use	use	NOUN
ijpds-4738	340	19	,	,	PUNCT
ijpds-4738	340	20	validation	validation	NOUN
ijpds-4738	340	21	of	of	ADP
ijpds-4738	340	22	analytical	analytical	ADJ
ijpds-4738	340	23	procedures	procedure	NOUN
ijpds-4738	340	24	:	:	PUNCT
ijpds-4738	340	25	methodology	methodology	NOUN
ijpds-4738	340	26	.	.	PUNCT
ijpds-4738	341	1	29	29	NUM
ijpds-4738	341	2	.	.	PUNCT
ijpds-4738	342	1	g.	g.	PROPN
ijpds-4738	342	2	ramana	ramana	PROPN
ijpds-4738	342	3	rao	rao	PROPN
ijpds-4738	342	4	,	,	PUNCT
ijpds-4738	342	5	s.s.n	s.s.n	NOUN
ijpds-4738	342	6	.	.	PUNCT
ijpds-4738	342	7	murthy	murthy	ADJ
ijpds-4738	342	8	,	,	PUNCT
ijpds-4738	342	9	and	and	CCONJ
ijpds-4738	342	10	p	p	NOUN
ijpds-4738	342	11	khadgapathi	khadgapathi	NOUN
ijpds-4738	342	12	,	,	PUNCT
ijpds-4738	342	13	gas	gas	NOUN
ijpds-4738	342	14	chromatography	chromatography	NOUN
ijpds-4738	342	15	to	to	ADP
ijpds-4738	342	16	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	342	17	analysis	analysis	NOUN
ijpds-4738	342	18	,	,	PUNCT
ijpds-4738	342	19	eastern	eastern	ADJ
ijpds-4738	342	20	pharmacist	pharmacist	NOUN
ijpds-4738	342	21	,	,	PUNCT
ijpds-4738	342	22	1987	1987	NUM
ijpds-4738	342	23	;	;	PUNCT
ijpds-4738	342	24	30(353	30(353	NUM
ijpds-4738	342	25	):	):	PUNCT
ijpds-4738	342	26	35	35	NUM
ijpds-4738	342	27	.	.	NUM
ijpds-4738	342	28	49	49	NUM
ijpds-4738	342	29	.	.	PUNCT
ijpds-4738	343	1	30	30	NUM
ijpds-4738	343	2	.	.	PUNCT
ijpds-4738	344	1	g.	g.	PROPN
ijpds-4738	344	2	ramana	ramana	PROPN
ijpds-4738	344	3	rao	rao	PROPN
ijpds-4738	344	4	,	,	PUNCT
ijpds-4738	344	5	s.s.n	s.s.n	NOUN
ijpds-4738	344	6	.	.	PUNCT
ijpds-4738	344	7	murthy	murthy	ADJ
ijpds-4738	344	8	,	,	PUNCT
ijpds-4738	344	9	and	and	CCONJ
ijpds-4738	344	10	p.	p.	PROPN
ijpds-4738	344	11	khadgapathi	khadgapathi	PROPN
ijpds-4738	344	12	,	,	PUNCT
ijpds-4738	344	13	high	high	ADJ
ijpds-4738	344	14	performance	performance	NOUN
ijpds-4738	344	15	liquid	liquid	NOUN
ijpds-4738	344	16	chromatography	chromatography	NOUN
ijpds-4738	344	17	and	and	CCONJ
ijpds-4738	344	18	its	its	PRON
ijpds-4738	344	19	role	role	NOUN
ijpds-4738	344	20	in	in	ADP
ijpds-4738	344	21	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	344	22	analysis	analysis	NOUN
ijpds-4738	344	23	,	,	PUNCT
ijpds-4738	344	24	eastern	eastern	ADJ
ijpds-4738	344	25	pharmacist	pharmacist	NOUN
ijpds-4738	344	26	,	,	PUNCT
ijpds-4738	344	27	1986	1986	NUM
ijpds-4738	344	28	;	;	PUNCT
ijpds-4738	344	29	29(346	29(346	NUM
ijpds-4738	344	30	):	):	PUNCT
ijpds-4738	344	31	53	53	NUM
ijpds-4738	344	32	.	.	NUM
ijpds-4738	344	33	31	31	NUM
ijpds-4738	344	34	.	.	PUNCT
ijpds-4738	345	1	r.a	r.a	PROPN
ijpds-4738	345	2	.	.	PROPN
ijpds-4738	345	3	day	day	NOUN
ijpds-4738	345	4	,	,	PUNCT
ijpds-4738	345	5	and	and	CCONJ
ijpds-4738	345	6	a.l	a.l	PROPN
ijpds-4738	345	7	,	,	PUNCT
ijpds-4738	345	8	underwood	underwood	PROPN
ijpds-4738	345	9	,	,	PUNCT
ijpds-4738	345	10	quantitative	quantitative	ADJ
ijpds-4738	345	11	analyses	analysis	NOUN
ijpds-4738	345	12	,	,	PUNCT
ijpds-4738	345	13	(	(	PUNCT
ijpds-4738	345	14	5th	5th	ADJ
ijpds-4738	345	15	ed	ed	NOUN
ijpds-4738	345	16	.	.	PROPN
ijpds-4738	345	17	,	,	PUNCT
ijpds-4738	345	18	prentice	prentice	PROPN
ijpds-4738	345	19	hall	hall	PROPN
ijpds-4738	345	20	,	,	PUNCT
ijpds-4738	345	21	new	new	ADJ
ijpds-4738	345	22	delhi	delhi	PROPN
ijpds-4738	345	23	,	,	PUNCT
ijpds-4738	345	24	1986	1986	NUM
ijpds-4738	345	25	.	.	PUNCT
ijpds-4738	346	1	32	32	NUM
ijpds-4738	346	2	.	.	PUNCT
ijpds-4738	347	1	macek	macek	PROPN
ijpds-4738	347	2	k.	k.	PROPN
ijpds-4738	347	3	pharmaceutical	pharmaceutical	PROPN
ijpds-4738	347	4	applications	application	NOUN
ijpds-4738	347	5	of	of	ADP
ijpds-4738	347	6	thin	thin	ADJ
ijpds-4738	347	7	-	-	PUNCT
ijpds-4738	347	8	layer	layer	NOUN
ijpds-4738	347	9	and	and	CCONJ
ijpds-4738	347	10	paper	paper	NOUN
ijpds-4738	347	11	chromatography	chromatography	NOUN
ijpds-4738	347	12	.	.	PUNCT
ijpds-4738	348	1	(	(	PUNCT
ijpds-4738	348	2	no	no	DET
ijpds-4738	348	3	title	title	NOUN
ijpds-4738	348	4	)	)	PUNCT
ijpds-4738	348	5	.	.	PUNCT
ijpds-4738	349	1	1972	1972	NUM
ijpds-4738	349	2	.	.	PUNCT
ijpds-4738	350	1	33	33	NUM
ijpds-4738	350	2	.	.	PUNCT
ijpds-4738	351	1	raunig	raunig	PROPN
ijpds-4738	351	2	dl	dl	PROPN
ijpds-4738	351	3	,	,	PUNCT
ijpds-4738	351	4	mcshane	mcshane	PROPN
ijpds-4738	351	5	lm	lm	PROPN
ijpds-4738	351	6	,	,	PUNCT
ijpds-4738	351	7	pennello	pennello	PROPN
ijpds-4738	351	8	g	g	PROPN
ijpds-4738	351	9	,	,	PUNCT
ijpds-4738	351	10	et	et	PROPN
ijpds-4738	351	11	al	al	PROPN
ijpds-4738	351	12	.	.	PROPN
ijpds-4738	351	13	quantitative	quantitative	ADJ
ijpds-4738	351	14	imaging	imaging	NOUN
ijpds-4738	351	15	biomarkers	biomarker	NOUN
ijpds-4738	351	16	:	:	PUNCT
ijpds-4738	351	17	a	a	DET
ijpds-4738	351	18	review	review	NOUN
ijpds-4738	351	19	of	of	ADP
ijpds-4738	351	20	statistical	statistical	ADJ
ijpds-4738	351	21	methods	method	NOUN
ijpds-4738	351	22	for	for	ADP
ijpds-4738	351	23	technical	technical	ADJ
ijpds-4738	351	24	performance	performance	NOUN
ijpds-4738	351	25	assessment	assessment	NOUN
ijpds-4738	351	26	.	.	PUNCT
ijpds-4738	352	1	statistical	statistical	ADJ
ijpds-4738	352	2	methods	method	NOUN
ijpds-4738	352	3	in	in	ADP
ijpds-4738	352	4	medical	medical	ADJ
ijpds-4738	352	5	research	research	NOUN
ijpds-4738	352	6	.	.	PUNCT
ijpds-4738	353	1	2015	2015	NUM
ijpds-4738	353	2	;	;	PUNCT
ijpds-4738	353	3	24(1):27	24(1):27	NUM
ijpds-4738	353	4	-	-	SYM
ijpds-4738	353	5	67	67	NUM
ijpds-4738	353	6	.	.	PUNCT
ijpds-4738	354	1	34	34	NUM
ijpds-4738	354	2	.	.	PUNCT
ijpds-4738	354	3	gonzález	gonzález	PROPN
ijpds-4738	354	4	ag	ag	PROPN
ijpds-4738	354	5	,	,	PUNCT
ijpds-4738	354	6	herrador	herrador	PROPN
ijpds-4738	354	7	má	má	PROPN
ijpds-4738	354	8	.	.	PUNCT
ijpds-4738	355	1	a	a	DET
ijpds-4738	355	2	practical	practical	ADJ
ijpds-4738	355	3	guide	guide	NOUN
ijpds-4738	355	4	to	to	ADP
ijpds-4738	355	5	analytical	analytical	ADJ
ijpds-4738	355	6	method	method	NOUN
ijpds-4738	355	7	validation	validation	NOUN
ijpds-4738	355	8	,	,	PUNCT
ijpds-4738	355	9	including	include	VERB
ijpds-4738	355	10	measurement	measurement	NOUN
ijpds-4738	355	11	uncertainty	uncertainty	NOUN
ijpds-4738	355	12	and	and	CCONJ
ijpds-4738	355	13	accuracy	accuracy	NOUN
ijpds-4738	355	14	profiles	profile	NOUN
ijpds-4738	355	15	.	.	PUNCT
ijpds-4738	356	1	trac	trac	NOUN
ijpds-4738	356	2	trends	trend	NOUN
ijpds-4738	356	3	in	in	ADP
ijpds-4738	356	4	analytical	analytical	ADJ
ijpds-4738	356	5	chemistry	chemistry	NOUN
ijpds-4738	356	6	.	.	PUNCT
ijpds-4738	357	1	2007	2007	NUM
ijpds-4738	357	2	;	;	PUNCT
ijpds-4738	357	3	26(3):227	26(3):227	NUM
ijpds-4738	357	4	-	-	SYM
ijpds-4738	357	5	38	38	NUM
ijpds-4738	357	6	.	.	PUNCT
ijpds-4738	357	7	35	35	NUM
ijpds-4738	357	8	.	.	PUNCT
ijpds-4738	358	1	ravisankar	ravisankar	PROPN
ijpds-4738	358	2	p	p	PROPN
ijpds-4738	358	3	,	,	PUNCT
ijpds-4738	358	4	rajyalakshmi	rajyalakshmi	ADJ
ijpds-4738	358	5	g	g	NOUN
ijpds-4738	358	6	,	,	PUNCT
ijpds-4738	358	7	devadasu	devadasu	PROPN
ijpds-4738	358	8	c	c	PROPN
ijpds-4738	358	9	,	,	PUNCT
ijpds-4738	358	10	et	et	PROPN
ijpds-4738	358	11	al	al	PROPN
ijpds-4738	358	12	.	.	PUNCT
ijpds-4738	359	1	instant	instant	ADJ
ijpds-4738	359	2	tips	tip	NOUN
ijpds-4738	359	3	for	for	ADP
ijpds-4738	359	4	right	right	ADJ
ijpds-4738	359	5	and	and	CCONJ
ijpds-4738	359	6	effective	effective	ADJ
ijpds-4738	359	7	approach	approach	NOUN
ijpds-4738	359	8	to	to	PART
ijpds-4738	359	9	solve	solve	VERB
ijpds-4738	359	10	hplc	hplc	NOUN
ijpds-4738	359	11	trouble	trouble	NOUN
ijpds-4738	359	12	shooting	shoot	VERB
ijpds-4738	359	13	.	.	PUNCT
ijpds-4738	360	1	journal	journal	PROPN
ijpds-4738	360	2	of	of	ADP
ijpds-4738	360	3	chemical	chemical	PROPN
ijpds-4738	360	4	and	and	CCONJ
ijpds-4738	360	5	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	360	6	sciences	science	NOUN
ijpds-4738	360	7	.	.	PUNCT
ijpds-4738	360	8	2014	2014	NUM
ijpds-4738	360	9	;	;	PUNCT
ijpds-4738	360	10	7(3):25974	7(3):25974	NUM
ijpds-4738	360	11	36	36	NUM
ijpds-4738	360	12	.	.	PUNCT
ijpds-4738	361	1	breaux	breaux	PROPN
ijpds-4738	361	2	j	j	PROPN
ijpds-4738	361	3	,	,	PUNCT
ijpds-4738	361	4	jones	jones	PROPN
ijpds-4738	361	5	k	k	PROPN
ijpds-4738	361	6	,	,	PUNCT
ijpds-4738	361	7	boulas	boulas	PROPN
ijpds-4738	361	8	p.	p.	PROPN
ijpds-4738	361	9	analytical	analytical	ADJ
ijpds-4738	361	10	methods	method	NOUN
ijpds-4738	361	11	development	development	NOUN
ijpds-4738	361	12	and	and	CCONJ
ijpds-4738	361	13	validation	validation	NOUN
ijpds-4738	361	14	.	.	PUNCT
ijpds-4738	362	1	pharm	pharm	NOUN
ijpds-4738	362	2	.	.	PUNCT
ijpds-4738	363	1	technol	technol	PROPN
ijpds-4738	363	2	.	.	PROPN
ijpds-4738	363	3	2003	2003	NUM
ijpds-4738	363	4	;	;	PUNCT
ijpds-4738	363	5	1:6	1:6	NUM
ijpds-4738	363	6	-	-	SYM
ijpds-4738	363	7	13	13	NUM
ijpds-4738	363	8	.	.	PUNCT
ijpds-4738	364	1	37	37	NUM
ijpds-4738	364	2	.	.	PUNCT
ijpds-4738	365	1	guideline	guideline	PROPN
ijpds-4738	365	2	ih	ih	PROPN
ijpds-4738	365	3	.	.	PUNCT
ijpds-4738	366	1	validation	validation	NOUN
ijpds-4738	366	2	of	of	ADP
ijpds-4738	366	3	analytical	analytical	ADJ
ijpds-4738	366	4	procedures	procedure	NOUN
ijpds-4738	366	5	:	:	PUNCT
ijpds-4738	366	6	text	text	NOUN
ijpds-4738	366	7	and	and	CCONJ
ijpds-4738	366	8	methodology	methodology	NOUN
ijpds-4738	366	9	.	.	PUNCT
ijpds-4738	367	1	q2	q2	NOUN
ijpds-4738	367	2	(	(	PUNCT
ijpds-4738	367	3	r1	r1	PROPN
ijpds-4738	367	4	)	)	PUNCT
ijpds-4738	367	5	.	.	PUNCT
ijpds-4738	368	1	2005	2005	NUM
ijpds-4738	368	2	;	;	PUNCT
ijpds-4738	368	3	1(20):05	1(20):05	NUM
ijpds-4738	368	4	.	.	PROPN
ijpds-4738	369	1	38	38	NUM
ijpds-4738	369	2	.	.	PUNCT
ijpds-4738	370	1	united	united	PROPN
ijpds-4738	370	2	states	states	PROPN
ijpds-4738	370	3	pharmacopeial	pharmacopeial	ADJ
ijpds-4738	370	4	convention	convention	NOUN
ijpds-4738	370	5	.	.	PUNCT
ijpds-4738	371	1	usp	usp	NOUN
ijpds-4738	371	2	33	33	NUM
ijpds-4738	371	3	nf	nf	NOUN
ijpds-4738	371	4	28	28	NUM
ijpds-4738	371	5	:	:	PUNCT
ijpds-4738	371	6	united	united	PROPN
ijpds-4738	371	7	states	states	PROPN
ijpds-4738	371	8	pharmacopeia	pharmacopeia	PROPN
ijpds-4738	372	1	[	[	X
ijpds-4738	372	2	and	and	CCONJ
ijpds-4738	372	3	]	]	X
ijpds-4738	372	4	national	national	ADJ
ijpds-4738	372	5	formulary	formulary	NOUN
ijpds-4738	372	6	.	.	PUNCT
ijpds-4738	373	1	reissue	reissue	NOUN
ijpds-4738	373	2	.	.	PUNCT
ijpds-4738	374	1	supplement	supplement	NOUN
ijpds-4738	374	2	2	2	NUM
ijpds-4738	374	3	.	.	PUNCT
ijpds-4738	374	4	a.	a.	PROPN
ijpds-4738	374	5	united	united	PROPN
ijpds-4738	374	6	states	states	PROPN
ijpds-4738	374	7	pharmacopeial	pharmacopeial	ADJ
ijpds-4738	374	8	convention	convention	NOUN
ijpds-4738	374	9	.	.	PUNCT
ijpds-4738	375	1	39	39	NUM
ijpds-4738	375	2	.	.	PUNCT
ijpds-4738	376	1	tiwari	tiwari	PROPN
ijpds-4738	376	2	g	g	PROPN
ijpds-4738	376	3	,	,	PUNCT
ijpds-4738	376	4	tiwari	tiwari	PROPN
ijpds-4738	376	5	r.	r.	PROPN
ijpds-4738	376	6	bioanalytical	bioanalytical	PROPN
ijpds-4738	376	7	method	method	PROPN
ijpds-4738	376	8	validation	validation	NOUN
ijpds-4738	376	9	:	:	PUNCT
ijpds-4738	376	10	an	an	DET
ijpds-4738	376	11	updated	update	VERB
ijpds-4738	376	12	review	review	NOUN
ijpds-4738	376	13	.	.	PUNCT
ijpds-4738	377	1	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	377	2	methods	method	NOUN
ijpds-4738	377	3	.	.	PUNCT
ijpds-4738	378	1	2010	2010	NUM
ijpds-4738	378	2	;	;	PUNCT
ijpds-4738	378	3	1(1):25	1(1):25	NUM
ijpds-4738	378	4	-	-	SYM
ijpds-4738	378	5	38	38	NUM
ijpds-4738	378	6	.	.	PUNCT
ijpds-4738	379	1	40	40	NUM
ijpds-4738	379	2	.	.	PUNCT
ijpds-4738	380	1	nirupa	nirupa	NOUN
ijpds-4738	380	2	g	g	PROPN
ijpds-4738	380	3	,	,	PUNCT
ijpds-4738	380	4	tripathi	tripathi	PROPN
ijpds-4738	380	5	um	um	INTJ
ijpds-4738	380	6	.	.	PUNCT
ijpds-4738	381	1	rp	rp	NOUN
ijpds-4738	381	2	-	-	PUNCT
ijpds-4738	381	3	hplc	hplc	NOUN
ijpds-4738	381	4	analytical	analytical	ADJ
ijpds-4738	381	5	method	method	NOUN
ijpds-4738	381	6	development	development	NOUN
ijpds-4738	381	7	and	and	CCONJ
ijpds-4738	381	8	validation	validation	NOUN
ijpds-4738	381	9	for	for	ADP
ijpds-4738	381	10	simultaneous	simultaneous	ADJ
ijpds-4738	381	11	estimation	estimation	NOUN
ijpds-4738	381	12	of	of	ADP
ijpds-4738	381	13	two	two	NUM
ijpds-4738	381	14	drugs	drug	NOUN
ijpds-4738	381	15	nitazoxanide	nitazoxanide	ADV
ijpds-4738	381	16	,	,	PUNCT
ijpds-4738	381	17	ofloxacin	ofloxacin	NOUN
ijpds-4738	381	18	and	and	CCONJ
ijpds-4738	381	19	its	its	PRON
ijpds-4738	381	20	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	381	21	dosage	dosage	NOUN
ijpds-4738	381	22	forms	form	NOUN
ijpds-4738	381	23	.	.	PUNCT
ijpds-4738	382	1	int	int	PROPN
ijpds-4738	382	2	j	j	PROPN
ijpds-4738	382	3	chemtech	chemtech	NOUN
ijpds-4738	382	4	res	re	NOUN
ijpds-4738	382	5	.	.	PUNCT
ijpds-4738	382	6	2012	2012	NUM
ijpds-4738	382	7	;	;	PUNCT
ijpds-4738	382	8	5(1):775	5(1):775	NUM
ijpds-4738	382	9	-	-	SYM
ijpds-4738	382	10	83	83	NUM
ijpds-4738	382	11	.	.	PUNCT
ijpds-4738	383	1	41	41	NUM
ijpds-4738	383	2	.	.	PUNCT
ijpds-4738	384	1	pagare	pagare	VERB
ijpds-4738	384	2	r	r	NOUN
ijpds-4738	384	3	,	,	PUNCT
ijpds-4738	384	4	aher	aher	PROPN
ijpds-4738	384	5	s	s	PROPN
ijpds-4738	384	6	,	,	PUNCT
ijpds-4738	384	7	bachhav	bachhav	PROPN
ijpds-4738	384	8	r.	r.	PROPN
ijpds-4738	384	9	a	a	DET
ijpds-4738	384	10	simple	simple	ADJ
ijpds-4738	384	11	analytical	analytical	ADJ
ijpds-4738	384	12	method	method	NOUN
ijpds-4738	384	13	development	development	NOUN
ijpds-4738	384	14	and	and	CCONJ
ijpds-4738	384	15	validation	validation	NOUN
ijpds-4738	384	16	of	of	ADP
ijpds-4738	384	17	azilsartan	azilsartan	PROPN
ijpds-4738	384	18	medoxomil	medoxomil	NOUN
ijpds-4738	384	19	in	in	ADP
ijpds-4738	384	20	bulk	bulk	ADJ
ijpds-4738	384	21	and	and	CCONJ
ijpds-4738	384	22	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	384	23	dosage	dosage	NOUN
ijpds-4738	384	24	form	form	NOUN
ijpds-4738	384	25	.	.	PUNCT
ijpds-4738	385	1	1	1	NUM
ijpds-4738	385	2	-	-	SYM
ijpds-4738	385	3	9	9	NUM
ijpds-4738	385	4	.	.	NUM
ijpds-4738	385	5	42	42	NUM
ijpds-4738	385	6	.	.	PUNCT
ijpds-4738	386	1	pharmacopeial	pharmacopeial	ADJ
ijpds-4738	386	2	convention	convention	PROPN
ijpds-4738	386	3	,	,	PUNCT
ijpds-4738	386	4	inc	inc	PROPN
ijpds-4738	386	5	,	,	PUNCT
ijpds-4738	386	6	2440	2440	NUM
ijpds-4738	386	7	;	;	PUNCT
ijpds-4738	386	8	2003.michel	2003.michel	PROPN
ijpds-4738	386	9	e.	e.	PROPN
ijpds-4738	386	10	swartz	swartz	PROPN
ijpds-4738	386	11	and	and	CCONJ
ijpds-4738	386	12	ira	ira	PROPN
ijpds-4738	386	13	s	s	PROPN
ijpds-4738	386	14	krull	krull	PROPN
ijpds-4738	386	15	;	;	PUNCT
ijpds-4738	386	16	analytical	analytical	ADJ
ijpds-4738	386	17	method	method	NOUN
ijpds-4738	386	18	development	development	NOUN
ijpds-4738	386	19	and	and	CCONJ
ijpds-4738	386	20	validation	validation	NOUN
ijpds-4738	386	21	;	;	PUNCT
ijpds-4738	386	22	special	special	ADJ
ijpds-4738	386	23	indian	indian	PROPN
ijpds-4738	386	24	edition	edition	PROPN
ijpds-4738	386	25	;	;	PUNCT
ijpds-4738	386	26	marcel	marcel	PROPN
ijpds-4738	386	27	dekker	dekker	PROPN
ijpds-4738	386	28	,	,	PUNCT
ijpds-4738	386	29	inc.73	inc.73	PROPN
ijpds-4738	386	30	-	-	PUNCT
ijpds-4738	386	31	74	74	NUM
ijpds-4738	386	32	.	.	PUNCT
ijpds-4738	387	1	43	43	NUM
ijpds-4738	387	2	.	.	PUNCT
ijpds-4738	388	1	dadhich	dadhich	PROPN
ijpds-4738	388	2	b	b	PROPN
ijpds-4738	388	3	,	,	PUNCT
ijpds-4738	388	4	goyal	goyal	PROPN
ijpds-4738	388	5	r	r	PROPN
ijpds-4738	388	6	,	,	PUNCT
ijpds-4738	388	7	agarwal	agarwal	PROPN
ijpds-4738	388	8	d.	d.	PROPN
ijpds-4738	388	9	a	a	DET
ijpds-4738	388	10	review	review	NOUN
ijpds-4738	388	11	on	on	ADP
ijpds-4738	388	12	:	:	PUNCT
ijpds-4738	388	13	development	development	NOUN
ijpds-4738	388	14	and	and	CCONJ
ijpds-4738	388	15	validation	validation	NOUN
ijpds-4738	388	16	of	of	ADP
ijpds-4738	388	17	hplc	hplc	NOUN
ijpds-4738	388	18	in	in	ADP
ijpds-4738	388	19	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	388	20	dosage	dosage	NOUN
ijpds-4738	388	21	form	form	NOUN
ijpds-4738	388	22	.	.	PUNCT
ijpds-4738	389	1	asian	asian	ADJ
ijpds-4738	389	2	journal	journal	PROPN
ijpds-4738	389	3	of	of	ADP
ijpds-4738	389	4	pharmaceutical	pharmaceutical	NOUN
ijpds-4738	389	5	research	research	NOUN
ijpds-4738	389	6	and	and	CCONJ
ijpds-4738	389	7	development	development	NOUN
ijpds-4738	389	8	.	.	PUNCT
ijpds-4738	390	1	2020	2020	NUM
ijpds-4738	390	2	;	;	PUNCT
ijpds-4738	390	3	8(4):110	8(4):110	NUM
ijpds-4738	390	4	-	-	SYM
ijpds-4738	390	5	21	21	NUM
ijpds-4738	390	6	.	.	PUNCT
ijpds-4738	391	1	44	44	NUM
ijpds-4738	391	2	.	.	PUNCT
ijpds-4738	392	1	united	united	PROPN
ijpds-4738	392	2	states	states	PROPN
ijpds-4738	392	3	pharmacopeial	pharmacopeial	ADJ
ijpds-4738	392	4	convention	convention	NOUN
ijpds-4738	392	5	.	.	PUNCT
ijpds-4738	393	1	usp	usp	NOUN
ijpds-4738	393	2	33	33	NUM
ijpds-4738	393	3	nf	nf	NOUN
ijpds-4738	393	4	28	28	NUM
ijpds-4738	393	5	:	:	PUNCT
ijpds-4738	393	6	united	united	PROPN
ijpds-4738	393	7	states	states	PROPN
ijpds-4738	393	8	pharmacopeia	pharmacopeia	PROPN
ijpds-4738	394	1	[	[	X
ijpds-4738	394	2	and	and	CCONJ
ijpds-4738	394	3	]	]	X
ijpds-4738	394	4	national	national	ADJ
ijpds-4738	394	5	formulary	formulary	NOUN
ijpds-4738	394	6	.	.	PUNCT
ijpds-4738	395	1	reissue	reissue	NOUN
ijpds-4738	395	2	.	.	PUNCT
ijpds-4738	396	1	supplement	supplement	NOUN
ijpds-4738	396	2	2	2	NUM
ijpds-4738	396	3	.	.	PUNCT
ijpds-4738	396	4	a.	a.	PROPN
ijpds-4738	396	5	united	united	PROPN
ijpds-4738	396	6	states	states	PROPN
ijpds-4738	396	7	pharmacopeial	pharmacopeial	ADJ
ijpds-4738	396	8	convention	convention	NOUN
ijpds-4738	396	9	.	.	PUNCT
ijpds-4738	397	1	45	45	NUM
ijpds-4738	397	2	.	.	PUNCT
ijpds-4738	397	3	alsante	alsante	PROPN
ijpds-4738	397	4	km	km	PROPN
ijpds-4738	397	5	,	,	PUNCT
ijpds-4738	397	6	ando	ando	PROPN
ijpds-4738	397	7	a	a	DET
ijpds-4738	397	8	,	,	PUNCT
ijpds-4738	397	9	brown	brown	ADJ
ijpds-4738	397	10	r	r	NOUN
ijpds-4738	397	11	,	,	PUNCT
ijpds-4738	397	12	et	et	PROPN
ijpds-4738	397	13	al	al	PROPN
ijpds-4738	397	14	.	.	PUNCT
ijpds-4738	398	1	the	the	DET
ijpds-4738	398	2	role	role	NOUN
ijpds-4738	398	3	of	of	ADP
ijpds-4738	398	4	degradant	degradant	ADJ
ijpds-4738	398	5	profiling	profiling	NOUN
ijpds-4738	398	6	in	in	ADP
ijpds-4738	398	7	active	active	ADJ
ijpds-4738	398	8	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	398	9	ingredients	ingredient	NOUN
ijpds-4738	398	10	and	and	CCONJ
ijpds-4738	398	11	drug	drug	NOUN
ijpds-4738	398	12	products	product	NOUN
ijpds-4738	398	13	.	.	PUNCT
ijpds-4738	399	1	advanced	advanced	ADJ
ijpds-4738	399	2	drug	drug	NOUN
ijpds-4738	399	3	delivery	delivery	NOUN
ijpds-4738	399	4	reviews	review	NOUN
ijpds-4738	399	5	.	.	PUNCT
ijpds-4738	400	1	2007	2007	NUM
ijpds-4738	400	2	;	;	PUNCT
ijpds-4738	400	3	59(1):29	59(1):29	NUM
ijpds-4738	400	4	-	-	SYM
ijpds-4738	400	5	37	37	NUM
ijpds-4738	400	6	.	.	PUNCT
ijpds-4738	401	1	how	how	SCONJ
ijpds-4738	401	2	to	to	PART
ijpds-4738	401	3	cite	cite	VERB
ijpds-4738	401	4	this	this	DET
ijpds-4738	401	5	article	article	NOUN
ijpds-4738	401	6	:	:	PUNCT
ijpds-4738	401	7	patil	patil	PROPN
ijpds-4738	401	8	rn	rn	PROPN
ijpds-4738	401	9	,	,	PUNCT
ijpds-4738	401	10	deore	deore	PROPN
ijpds-4738	401	11	bl	bl	PROPN
ijpds-4738	401	12	,	,	PUNCT
ijpds-4738	401	13	gurav	gurav	PROPN
ijpds-4738	401	14	dg	dg	PROPN
ijpds-4738	401	15	.	.	PUNCT
ijpds-4738	402	1	analytical	analytical	ADJ
ijpds-4738	402	2	method	method	NOUN
ijpds-4738	402	3	development	development	NOUN
ijpds-4738	402	4	and	and	CCONJ
ijpds-4738	402	5	validation	validation	NOUN
ijpds-4738	402	6	.	.	PUNCT
ijpds-4738	403	1	indian	indian	PROPN
ijpds-4738	403	2	j	j	PROPN
ijpds-4738	403	3	pharm	pharm	PROPN
ijpds-4738	403	4	drug	drug	PROPN
ijpds-4738	403	5	studies	study	NOUN
ijpds-4738	403	6	.	.	PUNCT
ijpds-4738	403	7	2024	2024	NUM
ijpds-4738	403	8	;	;	PUNCT
ijpds-4738	403	9	online	online	ADJ
ijpds-4738	403	10	first	first	ADJ
ijpds-4738	403	11	.	.	PUNCT
ijpds-4738	404	1	funding	funding	NOUN
ijpds-4738	404	2	:	:	PUNCT
ijpds-4738	404	3	none	none	NOUN
ijpds-4738	404	4	;	;	PUNCT
ijpds-4738	404	5	conflicts	conflict	NOUN
ijpds-4738	404	6	of	of	ADP
ijpds-4738	404	7	interest	interest	NOUN
ijpds-4738	404	8	:	:	PUNCT
ijpds-4738	404	9	none	none	NOUN
ijpds-4738	404	10	stated	state	VERB
ijpds-4738	404	11	objectives	objective	NOUN
ijpds-4738	404	12	:	:	PUNCT
ijpds-4738	404	13	1	1	X
ijpds-4738	404	14	.	.	X
ijpds-4738	404	15	development	development	NOUN
ijpds-4738	404	16	and	and	CCONJ
ijpds-4738	404	17	validation	validation	NOUN
ijpds-4738	404	18	of	of	ADP
ijpds-4738	404	19	analytical	analytical	ADJ
ijpds-4738	404	20	methods	method	NOUN
ijpds-4738	404	21	:	:	PUNCT
ijpds-4738	404	22	from	from	ADP
ijpds-4738	404	23	the	the	DET
ijpds-4738	404	24	formulation	formulation	NOUN
ijpds-4738	404	25	phase	phase	NOUN
ijpds-4738	404	26	all	all	DET
ijpds-4738	404	27	the	the	DET
ijpds-4738	404	28	way	way	NOUN
ijpds-4738	404	29	up	up	ADP
ijpds-4738	404	30	to	to	ADP
ijpds-4738	404	31	the	the	DET
ijpds-4738	404	32	manufacturing	manufacturing	NOUN
ijpds-4738	404	33	of	of	ADP
ijpds-4738	404	34	commercial	commercial	ADJ
ijpds-4738	404	35	batches	batch	NOUN
ijpds-4738	404	36	,	,	PUNCT
ijpds-4738	404	37	analytical	analytical	ADJ
ijpds-4738	404	38	techniques	technique	NOUN
ijpds-4738	404	39	are	be	AUX
ijpds-4738	404	40	essential	essential	ADJ
ijpds-4738	404	41	.	.	PUNCT
ijpds-4738	405	1	to	to	PART
ijpds-4738	405	2	make	make	VERB
ijpds-4738	405	3	sure	sure	ADJ
ijpds-4738	405	4	that	that	SCONJ
ijpds-4738	405	5	these	these	DET
ijpds-4738	405	6	techniques	technique	NOUN
ijpds-4738	405	7	yield	yield	VERB
ijpds-4738	405	8	accurate	accurate	ADJ
ijpds-4738	405	9	and	and	CCONJ
ijpds-4738	405	10	trustworthy	trustworthy	ADJ
ijpds-4738	405	11	findings	finding	NOUN
ijpds-4738	405	12	,	,	PUNCT
ijpds-4738	405	13	...	...	PUNCT
ijpds-4738	406	1	2	2	X
ijpds-4738	406	2	.	.	X
ijpds-4738	406	3	importance	importance	NOUN
ijpds-4738	406	4	of	of	ADP
ijpds-4738	406	5	validation	validation	NOUN
ijpds-4738	406	6	:	:	PUNCT
ijpds-4738	406	7	validation	validation	NOUN
ijpds-4738	406	8	guarantees	guarantee	VERB
ijpds-4738	406	9	that	that	SCONJ
ijpds-4738	406	10	analytical	analytical	ADJ
ijpds-4738	406	11	procedures	procedure	NOUN
ijpds-4738	406	12	satisfy	satisfy	VERB
ijpds-4738	406	13	specified	specify	VERB
ijpds-4738	406	14	requirements	requirement	NOUN
ijpds-4738	406	15	for	for	ADP
ijpds-4738	406	16	system	system	NOUN
ijpds-4738	406	17	appropriateness	appropriateness	NOUN
ijpds-4738	406	18	,	,	PUNCT
ijpds-4738	406	19	ruggedness	ruggedness	NOUN
ijpds-4738	406	20	,	,	PUNCT
ijpds-4738	406	21	robustness	robustness	NOUN
ijpds-4738	406	22	,	,	PUNCT
ijpds-4738	406	23	limit	limit	NOUN
ijpds-4738	406	24	of	of	ADP
ijpds-4738	406	25	detection	detection	NOUN
ijpds-4738	406	26	(	(	PUNCT
ijpds-4738	406	27	lod	lod	PROPN
ijpds-4738	406	28	)	)	PUNCT
ijpds-4738	406	29	,	,	PUNCT
ijpds-4738	406	30	limit	limit	NOUN
ijpds-4738	406	31	of	of	ADP
ijpds-4738	406	32	quantitation	quantitation	NOUN
ijpds-4738	406	33	(	(	PUNCT
ijpds-4738	406	34	loq	loq	PROPN
ijpds-4738	406	35	)	)	PUNCT
ijpds-4738	406	36	,	,	PUNCT
ijpds-4738	406	37	accuracy	accuracy	NOUN
ijpds-4738	406	38	,	,	PUNCT
ijpds-4738	406	39	specificity	specificity	NOUN
ijpds-4738	406	40	,	,	PUNCT
ijpds-4738	406	41	and	and	CCONJ
ijpds-4738	406	42	precisio	precisio	ADV
ijpds-4738	406	43	...	...	PUNCT
ijpds-4738	407	1	3	3	X
ijpds-4738	407	2	.	.	X
ijpds-4738	407	3	regulatory	regulatory	ADJ
ijpds-4738	407	4	bodies	body	NOUN
ijpds-4738	407	5	:	:	PUNCT
ijpds-4738	407	6	validation	validation	NOUN
ijpds-4738	407	7	procedures	procedure	NOUN
ijpds-4738	407	8	follow	follow	VERB
ijpds-4738	407	9	gmp	gmp	PROPN
ijpds-4738	407	10	guidelines	guideline	NOUN
ijpds-4738	407	11	and	and	CCONJ
ijpds-4738	407	12	are	be	AUX
ijpds-4738	407	13	recorded	record	VERB
ijpds-4738	407	14	.	.	PUNCT
ijpds-4738	408	1	in	in	ADP
ijpds-4738	408	2	order	order	NOUN
ijpds-4738	408	3	to	to	PART
ijpds-4738	408	4	guarantee	guarantee	VERB
ijpds-4738	408	5	the	the	DET
ijpds-4738	408	6	security	security	NOUN
ijpds-4738	408	7	,	,	PUNCT
ijpds-4738	408	8	effectiveness	effectiveness	NOUN
ijpds-4738	408	9	,	,	PUNCT
ijpds-4738	408	10	and	and	CCONJ
ijpds-4738	408	11	caliber	caliber	NOUN
ijpds-4738	408	12	of	of	ADP
ijpds-4738	408	13	their	their	PRON
ijpds-4738	408	14	goods	good	NOUN
ijpds-4738	408	15	,	,	PUNCT
ijpds-4738	408	16	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	408	17	companies	company	NOUN
ijpds-4738	408	18	must	must	AUX
ijpds-4738	408	19	abide	abide	VERB
ijpds-4738	408	20	by	by	ADP
ijpds-4738	408	21	these	these	DET
ijpds-4738	408	22	rules	rule	NOUN
ijpds-4738	408	23	.	.	PUNCT
ijpds-4738	409	1	4	4	X
ijpds-4738	409	2	.	.	X
ijpds-4738	409	3	stages	stage	NOUN
ijpds-4738	409	4	of	of	ADP
ijpds-4738	409	5	validation	validation	NOUN
ijpds-4738	409	6	:	:	PUNCT
ijpds-4738	409	7	testing	testing	NOUN
ijpds-4738	409	8	is	be	AUX
ijpds-4738	409	9	done	do	VERB
ijpds-4738	409	10	on	on	ADP
ijpds-4738	409	11	raw	raw	ADJ
ijpds-4738	409	12	materials	material	NOUN
ijpds-4738	409	13	and	and	CCONJ
ijpds-4738	409	14	final	final	ADJ
ijpds-4738	409	15	products	product	NOUN
ijpds-4738	409	16	in	in	ADP
ijpds-4738	409	17	every	every	DET
ijpds-4738	409	18	stage	stage	NOUN
ijpds-4738	409	19	of	of	ADP
ijpds-4738	409	20	the	the	DET
ijpds-4738	409	21	production	production	NOUN
ijpds-4738	409	22	method	method	NOUN
ijpds-4738	409	23	to	to	PART
ijpds-4738	409	24	ensure	ensure	VERB
ijpds-4738	409	25	their	their	PRON
ijpds-4738	409	26	stability	stability	NOUN
ijpds-4738	409	27	.	.	PUNCT
ijpds-4738	410	1	this	this	DET
ijpds-4738	410	2	all	all	ADV
ijpds-4738	410	3	-	-	PUNCT
ijpds-4738	410	4	encompassing	encompass	VERB
ijpds-4738	410	5	strategy	strategy	NOUN
ijpds-4738	410	6	guarantees	guarantee	VERB
ijpds-4738	410	7	that	that	SCONJ
ijpds-4738	410	8	the	the	DET
ijpds-4738	410	9	procedure	procedure	NOUN
ijpds-4738	410	10	is	be	AUX
ijpds-4738	410	11	validated	validate	VERB
ijpds-4738	410	12	and	and	CCONJ
ijpds-4738	410	13	satisfies	satisfy	VERB
ijpds-4738	410	14	necessary	necessary	ADJ
ijpds-4738	410	15	requireme	requireme	ADJ
ijpds-4738	410	16	...	...	PUNCT
ijpds-4738	410	17	5	5	X
ijpds-4738	410	18	.	.	X
ijpds-4738	410	19	method	method	PROPN
ijpds-4738	410	20	development	development	NOUN
ijpds-4738	410	21	:	:	PUNCT
ijpds-4738	410	22	in	in	ADP
ijpds-4738	410	23	order	order	NOUN
ijpds-4738	410	24	to	to	PART
ijpds-4738	410	25	assure	assure	VERB
ijpds-4738	410	26	that	that	SCONJ
ijpds-4738	410	27	analyses	analysis	NOUN
ijpds-4738	410	28	are	be	AUX
ijpds-4738	410	29	sensitive	sensitive	ADJ
ijpds-4738	410	30	,	,	PUNCT
ijpds-4738	410	31	selective	selective	ADJ
ijpds-4738	410	32	,	,	PUNCT
ijpds-4738	410	33	and	and	CCONJ
ijpds-4738	410	34	capable	capable	ADJ
ijpds-4738	410	35	of	of	ADP
ijpds-4738	410	36	reliably	reliably	ADV
ijpds-4738	410	37	delivering	deliver	VERB
ijpds-4738	410	38	accurate	accurate	ADJ
ijpds-4738	410	39	findings	finding	NOUN
ijpds-4738	410	40	under	under	ADP
ijpds-4738	410	41	a	a	DET
ijpds-4738	410	42	variety	variety	NOUN
ijpds-4738	410	43	of	of	ADP
ijpds-4738	410	44	the	the	DET
ijpds-4738	410	45	settings	setting	NOUN
ijpds-4738	410	46	window	window	NOUN
ijpds-4738	410	47	,	,	PUNCT
ijpds-4738	410	48	proper	proper	ADJ
ijpds-4738	410	49	method	method	NOUN
ijpds-4738	410	50	development	development	NOUN
ijpds-4738	410	51	entails	entail	VERB
ijpds-4738	410	52	improving	improve	VERB
ijpds-4738	410	53	and	and	CCONJ
ijpds-4738	410	54	refining	refine	VERB
ijpds-4738	410	55	these	these	DET
ijpds-4738	410	56	processes	process	NOUN
ijpds-4738	410	57	.	.	PUNCT
ijpds-4738	411	1	6	6	NUM
ijpds-4738	411	2	.	.	NOUN
ijpds-4738	411	3	routine	routine	ADJ
ijpds-4738	411	4	and	and	CCONJ
ijpds-4738	411	5	stability	stability	NOUN
ijpds-4738	411	6	testing	testing	NOUN
ijpds-4738	411	7	:	:	PUNCT
ijpds-4738	411	8	validation	validation	NOUN
ijpds-4738	411	9	parameters	parameter	NOUN
ijpds-4738	411	10	are	be	AUX
ijpds-4738	411	11	used	use	VERB
ijpds-4738	411	12	in	in	ADP
ijpds-4738	411	13	stability	stability	NOUN
ijpds-4738	411	14	testing	testing	NOUN
ijpds-4738	411	15	as	as	ADV
ijpds-4738	411	16	well	well	ADV
ijpds-4738	411	17	as	as	ADP
ijpds-4738	411	18	routine	routine	ADJ
ijpds-4738	411	19	analysis	analysis	NOUN
ijpds-4738	411	20	,	,	PUNCT
ijpds-4738	411	21	as	as	SCONJ
ijpds-4738	411	22	the	the	DET
ijpds-4738	411	23	latter	latter	ADJ
ijpds-4738	411	24	evaluates	evaluate	VERB
ijpds-4738	411	25	the	the	DET
ijpds-4738	411	26	stability	stability	NOUN
ijpds-4738	411	27	of	of	ADP
ijpds-4738	411	28	the	the	DET
ijpds-4738	411	29	final	final	ADJ
ijpds-4738	411	30	product	product	NOUN
ijpds-4738	411	31	and	and	CCONJ
ijpds-4738	411	32	the	the	DET
ijpds-4738	411	33	pharmaceutical	pharmaceutical	ADJ
ijpds-4738	411	34	ingredient	ingredient	NOUN
ijpds-4738	411	35	that	that	PRON
ijpds-4738	411	36	is	be	AUX
ijpds-4738	411	37	active	active	ADJ
ijpds-4738	411	38	(	(	PUNCT
ijpds-4738	411	39	api	api	NOUN
ijpds-4738	411	40	)	)	PUNCT
ijpds-4738	411	41	over	over	ADP
ijpds-4738	411	42	time	time	NOUN
ijpds-4738	412	1	[	[	X
ijpds-4738	412	2	5,6,7	5,6,7	NOUN
ijpds-4738	412	3	]	]	X
ijpds-4738	412	4	.	.	PUNCT
ijpds-4738	413	1	method	method	PROPN
ijpds-4738	413	2	development	development	NOUN