id	sid	tid	token	lemma	pos
ijpds-7913	1	1	agrawal	agrawal	VERB
ijpds-7913	1	2	therapeutic	therapeutic	ADJ
ijpds-7913	1	3	drug	drug	NOUN
ijpds-7913	1	4	monitoring	monitoring	NOUN
ijpds-7913	1	5	in	in	ADP
ijpds-7913	1	6	critical	critical	ADJ
ijpds-7913	1	7	care	care	NOUN
ijpds-7913	1	8	and	and	CCONJ
ijpds-7913	1	9	transplants	transplant	NOUN
ijpds-7913	1	10	online	online	ADJ
ijpds-7913	1	11	first	first	PROPN
ijpds-7913	1	12	indian	indian	PROPN
ijpds-7913	1	13	j	j	PROPN
ijpds-7913	1	14	pharm	pharm	PROPN
ijpds-7913	1	15	drug	drug	PROPN
ijpds-7913	1	16	studies	study	NOUN
ijpds-7913	1	17	|	|	ADV
ijpds-7913	1	18	1	1	NUM
ijpds-7913	1	19	review	review	NOUN
ijpds-7913	1	20	article	article	NOUN
ijpds-7913	1	21	therapeutic	therapeutic	ADJ
ijpds-7913	1	22	drug	drug	NOUN
ijpds-7913	1	23	monitoring	monitoring	NOUN
ijpds-7913	1	24	(	(	PUNCT
ijpds-7913	1	25	tdm	tdm	NOUN
ijpds-7913	1	26	):	):	PUNCT
ijpds-7913	1	27	a	a	DET
ijpds-7913	1	28	necessity	necessity	NOUN
ijpds-7913	1	29	in	in	ADP
ijpds-7913	1	30	critical	critical	ADJ
ijpds-7913	1	31	care	care	NOUN
ijpds-7913	1	32	and	and	CCONJ
ijpds-7913	1	33	transplant	transplant	NOUN
ijpds-7913	1	34	settings	setting	NOUN
ijpds-7913	1	35	rashmi	rashmi	PROPN
ijpds-7913	1	36	agrawal	agrawal	PROPN
ijpds-7913	1	37	from	from	ADP
ijpds-7913	1	38	,	,	PUNCT
ijpds-7913	1	39	consultant	consultant	NOUN
ijpds-7913	1	40	,	,	PUNCT
ijpds-7913	1	41	devmata	devmata	NOUN
ijpds-7913	1	42	hospital	hospital	NOUN
ijpds-7913	1	43	,	,	PUNCT
ijpds-7913	1	44	bhopal	bhopal	PROPN
ijpds-7913	1	45	,	,	PUNCT
ijpds-7913	1	46	madhya	madhya	PROPN
ijpds-7913	1	47	pradesh	pradesh	PROPN
ijpds-7913	1	48	,	,	PUNCT
ijpds-7913	1	49	india	india	PROPN
ijpds-7913	1	50	abstract	abstract	ADJ
ijpds-7913	1	51	therapeutic	therapeutic	ADJ
ijpds-7913	1	52	drug	drug	NOUN
ijpds-7913	1	53	monitoring	monitoring	NOUN
ijpds-7913	1	54	(	(	PUNCT
ijpds-7913	1	55	tdm	tdm	NOUN
ijpds-7913	1	56	)	)	PUNCT
ijpds-7913	1	57	personalizes	personalize	VERB
ijpds-7913	1	58	dosage	dosage	NOUN
ijpds-7913	1	59	by	by	ADP
ijpds-7913	1	60	quantifying	quantify	VERB
ijpds-7913	1	61	plasma	plasma	NOUN
ijpds-7913	1	62	concentrations	concentration	NOUN
ijpds-7913	1	63	to	to	PART
ijpds-7913	1	64	enhance	enhance	VERB
ijpds-7913	1	65	treatment	treatment	NOUN
ijpds-7913	1	66	effectiveness	effectiveness	NOUN
ijpds-7913	1	67	and	and	CCONJ
ijpds-7913	1	68	reduce	reduce	VERB
ijpds-7913	1	69	toxicity	toxicity	NOUN
ijpds-7913	1	70	.	.	PUNCT
ijpds-7913	2	1	in	in	ADP
ijpds-7913	2	2	critically	critically	ADV
ijpds-7913	2	3	sick	sick	ADJ
ijpds-7913	2	4	patients	patient	NOUN
ijpds-7913	2	5	and	and	CCONJ
ijpds-7913	2	6	transplant	transplant	NOUN
ijpds-7913	2	7	recipients	recipient	NOUN
ijpds-7913	2	8	,	,	PUNCT
ijpds-7913	2	9	pathophysiological	pathophysiological	ADJ
ijpds-7913	2	10	alterations	alteration	NOUN
ijpds-7913	2	11	,	,	PUNCT
ijpds-7913	2	12	restricted	restrict	VERB
ijpds-7913	2	13	therapeutic	therapeutic	ADJ
ijpds-7913	2	14	indices	index	NOUN
ijpds-7913	2	15	,	,	PUNCT
ijpds-7913	2	16	and	and	CCONJ
ijpds-7913	2	17	organ	organ	NOUN
ijpds-7913	2	18	support	support	NOUN
ijpds-7913	2	19	measures	measure	NOUN
ijpds-7913	2	20	frequently	frequently	ADV
ijpds-7913	2	21	result	result	VERB
ijpds-7913	2	22	in	in	ADP
ijpds-7913	2	23	unexpected	unexpected	ADJ
ijpds-7913	2	24	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	2	25	(	(	PUNCT
ijpds-7913	2	26	pk	pk	NOUN
ijpds-7913	2	27	)	)	PUNCT
ijpds-7913	2	28	.	.	PUNCT
ijpds-7913	3	1	this	this	DET
ijpds-7913	3	2	study	study	NOUN
ijpds-7913	3	3	emphasizes	emphasize	VERB
ijpds-7913	3	4	tdm	tdm	PROPN
ijpds-7913	3	5	's	's	PART
ijpds-7913	3	6	significance	significance	NOUN
ijpds-7913	3	7	in	in	ADP
ijpds-7913	3	8	critical	critical	ADJ
ijpds-7913	3	9	care	care	NOUN
ijpds-7913	3	10	and	and	CCONJ
ijpds-7913	3	11	transplantation	transplantation	NOUN
ijpds-7913	3	12	,	,	PUNCT
ijpds-7913	3	13	concentrating	concentrate	VERB
ijpds-7913	3	14	on	on	ADP
ijpds-7913	3	15	antimicrobials	antimicrobial	NOUN
ijpds-7913	3	16	such	such	ADJ
ijpds-7913	3	17	as	as	ADP
ijpds-7913	3	18	vancomycin	vancomycin	PROPN
ijpds-7913	3	19	,	,	PUNCT
ijpds-7913	3	20	β	β	NOUN
ijpds-7913	3	21	-	-	NOUN
ijpds-7913	3	22	lactams	lactam	NOUN
ijpds-7913	3	23	,	,	PUNCT
ijpds-7913	3	24	antifungals	antifungal	NOUN
ijpds-7913	3	25	,	,	PUNCT
ijpds-7913	3	26	and	and	CCONJ
ijpds-7913	3	27	immunosuppressants	immunosuppressant	NOUN
ijpds-7913	3	28	like	like	ADP
ijpds-7913	3	29	tacrolimus	tacrolimus	NOUN
ijpds-7913	3	30	,	,	PUNCT
ijpds-7913	3	31	cyclosporine	cyclosporine	NOUN
ijpds-7913	3	32	,	,	PUNCT
ijpds-7913	3	33	and	and	CCONJ
ijpds-7913	3	34	mycophenolic	mycophenolic	ADJ
ijpds-7913	3	35	acid	acid	NOUN
ijpds-7913	3	36	,	,	PUNCT
ijpds-7913	3	37	substantiated	substantiate	VERB
ijpds-7913	3	38	by	by	ADP
ijpds-7913	3	39	pubmed	pubmed	PROPN
ijpds-7913	3	40	-	-	PUNCT
ijpds-7913	3	41	cited	cite	VERB
ijpds-7913	3	42	literature	literature	NOUN
ijpds-7913	3	43	.	.	PUNCT
ijpds-7913	4	1	key	key	ADJ
ijpds-7913	4	2	words	word	NOUN
ijpds-7913	4	3	:	:	PUNCT
ijpds-7913	4	4	tdm	tdm	ADJ
ijpds-7913	4	5	,	,	PUNCT
ijpds-7913	4	6	critical	critical	ADJ
ijpds-7913	4	7	illness	illness	NOUN
ijpds-7913	4	8	,	,	PUNCT
ijpds-7913	4	9	transplantation	transplantation	NOUN
ijpds-7913	4	10	,	,	PUNCT
ijpds-7913	4	11	vancomycin	vancomycin	PROPN
ijpds-7913	4	12	,	,	PUNCT
ijpds-7913	4	13	β	β	NOUN
ijpds-7913	4	14	-	-	NOUN
ijpds-7913	4	15	lactams	lactam	NOUN
ijpds-7913	4	16	,	,	PUNCT
ijpds-7913	4	17	antifungals	antifungal	NOUN
ijpds-7913	4	18	,	,	PUNCT
ijpds-7913	4	19	immunosuppressants	immunosuppressant	NOUN
ijpds-7913	4	20	herapeutic	herapeutic	ADJ
ijpds-7913	4	21	drug	drug	NOUN
ijpds-7913	4	22	monitoring	monitoring	NOUN
ijpds-7913	4	23	(	(	PUNCT
ijpds-7913	4	24	tdm	tdm	NOUN
ijpds-7913	4	25	)	)	PUNCT
ijpds-7913	4	26	is	be	AUX
ijpds-7913	4	27	the	the	DET
ijpds-7913	4	28	practice	practice	NOUN
ijpds-7913	4	29	of	of	ADP
ijpds-7913	4	30	adjusting	adjust	VERB
ijpds-7913	4	31	a	a	DET
ijpds-7913	4	32	patient	patient	NOUN
ijpds-7913	4	33	's	's	PART
ijpds-7913	4	34	medication	medication	NOUN
ijpds-7913	4	35	dosage	dosage	NOUN
ijpds-7913	4	36	to	to	PART
ijpds-7913	4	37	maintain	maintain	VERB
ijpds-7913	4	38	drug	drug	NOUN
ijpds-7913	4	39	concentrations	concentration	NOUN
ijpds-7913	4	40	within	within	ADP
ijpds-7913	4	41	a	a	DET
ijpds-7913	4	42	specified	specify	VERB
ijpds-7913	4	43	therapeutic	therapeutic	ADJ
ijpds-7913	4	44	range	range	NOUN
ijpds-7913	4	45	in	in	ADP
ijpds-7913	4	46	the	the	DET
ijpds-7913	4	47	bloodstream	bloodstream	NOUN
ijpds-7913	4	48	[	[	X
ijpds-7913	4	49	1	1	NUM
ijpds-7913	4	50	]	]	PUNCT
ijpds-7913	4	51	.	.	PUNCT
ijpds-7913	5	1	tdm	tdm	PROPN
ijpds-7913	5	2	employs	employ	VERB
ijpds-7913	5	3	a	a	DET
ijpds-7913	5	4	comprehensive	comprehensive	ADJ
ijpds-7913	5	5	analysis	analysis	NOUN
ijpds-7913	5	6	of	of	ADP
ijpds-7913	5	7	pharmaceutics	pharmaceutic	NOUN
ijpds-7913	5	8	,	,	PUNCT
ijpds-7913	5	9	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	5	10	,	,	PUNCT
ijpds-7913	5	11	and	and	CCONJ
ijpds-7913	5	12	pharmacodynamics	pharmacodynamic	NOUN
ijpds-7913	5	13	to	to	PART
ijpds-7913	5	14	assess	assess	VERB
ijpds-7913	5	15	the	the	DET
ijpds-7913	5	16	safety	safety	NOUN
ijpds-7913	5	17	and	and	CCONJ
ijpds-7913	5	18	efficacy	efficacy	NOUN
ijpds-7913	5	19	of	of	ADP
ijpds-7913	5	20	a	a	DET
ijpds-7913	5	21	medication	medication	NOUN
ijpds-7913	5	22	across	across	ADP
ijpds-7913	5	23	many	many	ADJ
ijpds-7913	5	24	clinical	clinical	ADJ
ijpds-7913	5	25	contexts	contexts	NOUN
ijpds-7913	5	26	.	.	PUNCT
ijpds-7913	6	1	for	for	ADP
ijpds-7913	6	2	therapeutic	therapeutic	ADJ
ijpds-7913	6	3	drug	drug	NOUN
ijpds-7913	6	4	monitoring	monitoring	NOUN
ijpds-7913	6	5	(	(	PUNCT
ijpds-7913	6	6	tdm	tdm	NOUN
ijpds-7913	6	7	)	)	PUNCT
ijpds-7913	6	8	to	to	PART
ijpds-7913	6	9	be	be	AUX
ijpds-7913	6	10	effective	effective	ADJ
ijpds-7913	6	11	,	,	PUNCT
ijpds-7913	6	12	the	the	DET
ijpds-7913	6	13	concentration	concentration	NOUN
ijpds-7913	6	14	of	of	ADP
ijpds-7913	6	15	a	a	DET
ijpds-7913	6	16	medication	medication	NOUN
ijpds-7913	6	17	must	must	AUX
ijpds-7913	6	18	be	be	AUX
ijpds-7913	6	19	assessed	assess	VERB
ijpds-7913	6	20	in	in	ADP
ijpds-7913	6	21	several	several	ADJ
ijpds-7913	6	22	physiological	physiological	ADJ
ijpds-7913	6	23	fluids	fluid	NOUN
ijpds-7913	6	24	.	.	PUNCT
ijpds-7913	7	1	a	a	DET
ijpds-7913	7	2	depiction	depiction	NOUN
ijpds-7913	7	3	of	of	ADP
ijpds-7913	7	4	these	these	DET
ijpds-7913	7	5	concentrations	concentration	NOUN
ijpds-7913	7	6	in	in	ADP
ijpds-7913	7	7	relation	relation	NOUN
ijpds-7913	7	8	to	to	ADP
ijpds-7913	7	9	significant	significant	ADJ
ijpds-7913	7	10	clinical	clinical	ADJ
ijpds-7913	7	11	considerations	consideration	NOUN
ijpds-7913	7	12	is	be	AUX
ijpds-7913	7	13	provided	provide	VERB
ijpds-7913	7	14	[	[	PUNCT
ijpds-7913	7	15	2	2	NUM
ijpds-7913	7	16	]	]	PUNCT
ijpds-7913	7	17	.	.	PUNCT
ijpds-7913	8	1	in	in	ADP
ijpds-7913	8	2	the	the	DET
ijpds-7913	8	3	last	last	ADJ
ijpds-7913	8	4	ten	ten	NUM
ijpds-7913	8	5	years	year	NOUN
ijpds-7913	8	6	,	,	PUNCT
ijpds-7913	8	7	the	the	DET
ijpds-7913	8	8	theory	theory	NOUN
ijpds-7913	8	9	,	,	PUNCT
ijpds-7913	8	10	practice	practice	NOUN
ijpds-7913	8	11	,	,	PUNCT
ijpds-7913	8	12	and	and	CCONJ
ijpds-7913	8	13	clinical	clinical	ADJ
ijpds-7913	8	14	relevance	relevance	NOUN
ijpds-7913	8	15	of	of	ADP
ijpds-7913	8	16	therapeutic	therapeutic	ADJ
ijpds-7913	8	17	drug	drug	NOUN
ijpds-7913	8	18	monitoring	monitoring	NOUN
ijpds-7913	8	19	(	(	PUNCT
ijpds-7913	8	20	tdm	tdm	X
ijpds-7913	8	21	)	)	PUNCT
ijpds-7913	8	22	have	have	AUX
ijpds-7913	8	23	significantly	significantly	ADV
ijpds-7913	8	24	evolved	evolve	VERB
ijpds-7913	8	25	due	due	ADP
ijpds-7913	8	26	to	to	ADP
ijpds-7913	8	27	the	the	DET
ijpds-7913	8	28	advent	advent	NOUN
ijpds-7913	8	29	of	of	ADP
ijpds-7913	8	30	widely	widely	ADV
ijpds-7913	8	31	accessible	accessible	ADJ
ijpds-7913	8	32	and	and	CCONJ
ijpds-7913	8	33	technically	technically	ADV
ijpds-7913	8	34	proficient	proficient	ADJ
ijpds-7913	8	35	modelling	modelling	NOUN
ijpds-7913	8	36	,	,	PUNCT
ijpds-7913	8	37	simulation	simulation	NOUN
ijpds-7913	8	38	,	,	PUNCT
ijpds-7913	8	39	and	and	CCONJ
ijpds-7913	8	40	dosing	dose	VERB
ijpds-7913	8	41	software	software	NOUN
ijpds-7913	8	42	tools	tool	NOUN
ijpds-7913	8	43	[	[	X
ijpds-7913	8	44	3	3	NUM
ijpds-7913	8	45	]	]	PUNCT
ijpds-7913	8	46	.	.	PUNCT
ijpds-7913	9	1	consequently	consequently	ADV
ijpds-7913	9	2	,	,	PUNCT
ijpds-7913	9	3	tdm	tdm	PROPN
ijpds-7913	9	4	,	,	PUNCT
ijpds-7913	9	5	once	once	ADV
ijpds-7913	9	6	a	a	DET
ijpds-7913	9	7	peripheral	peripheral	ADJ
ijpds-7913	9	8	area	area	NOUN
ijpds-7913	9	9	of	of	ADP
ijpds-7913	9	10	clinical	clinical	ADJ
ijpds-7913	9	11	chemistry	chemistry	NOUN
ijpds-7913	9	12	,	,	PUNCT
ijpds-7913	9	13	has	have	AUX
ijpds-7913	9	14	evolved	evolve	VERB
ijpds-7913	9	15	into	into	ADP
ijpds-7913	9	16	a	a	DET
ijpds-7913	9	17	multidisciplinary	multidisciplinary	ADJ
ijpds-7913	9	18	domain	domain	NOUN
ijpds-7913	9	19	of	of	ADP
ijpds-7913	9	20	clinical	clinical	ADJ
ijpds-7913	9	21	medicine	medicine	NOUN
ijpds-7913	9	22	,	,	PUNCT
ijpds-7913	9	23	enabling	enable	VERB
ijpds-7913	9	24	laboratory	laboratory	NOUN
ijpds-7913	9	25	and	and	CCONJ
ijpds-7913	9	26	pharmacometrics	pharmacometric	NOUN
ijpds-7913	9	27	experts	expert	NOUN
ijpds-7913	9	28	to	to	PART
ijpds-7913	9	29	provide	provide	VERB
ijpds-7913	9	30	extremely	extremely	ADV
ijpds-7913	9	31	pertinent	pertinent	ADJ
ijpds-7913	9	32	clinical	clinical	ADJ
ijpds-7913	9	33	information	information	NOUN
ijpds-7913	9	34	to	to	PART
ijpds-7913	9	35	support	support	VERB
ijpds-7913	9	36	pharmacotherapy	pharmacotherapy	NOUN
ijpds-7913	9	37	management	management	NOUN
ijpds-7913	9	38	.	.	PUNCT
ijpds-7913	10	1	the	the	DET
ijpds-7913	10	2	emerging	emerge	VERB
ijpds-7913	10	3	field	field	NOUN
ijpds-7913	10	4	is	be	AUX
ijpds-7913	10	5	termed	term	VERB
ijpds-7913	10	6	“	"	PUNCT
ijpds-7913	10	7	model	model	NOUN
ijpds-7913	10	8	-	-	PUNCT
ijpds-7913	10	9	informed	inform	VERB
ijpds-7913	10	10	precision	precision	NOUN
ijpds-7913	10	11	dosing	dosing	NOUN
ijpds-7913	10	12	”	"	PUNCT
ijpds-7913	10	13	and	and	CCONJ
ijpds-7913	10	14	is	be	AUX
ijpds-7913	10	15	poised	poise	VERB
ijpds-7913	10	16	to	to	PART
ijpds-7913	10	17	revolutionize	revolutionize	VERB
ijpds-7913	10	18	medicine	medicine	NOUN
ijpds-7913	10	19	through	through	ADP
ijpds-7913	10	20	enhancements	enhancement	NOUN
ijpds-7913	10	21	in	in	ADP
ijpds-7913	10	22	performance	performance	NOUN
ijpds-7913	10	23	and	and	CCONJ
ijpds-7913	10	24	usefulness	usefulness	NOUN
ijpds-7913	10	25	facilitated	facilitate	VERB
ijpds-7913	10	26	by	by	ADP
ijpds-7913	10	27	machine	machine	NOUN
ijpds-7913	10	28	learning	learning	NOUN
ijpds-7913	10	29	and	and	CCONJ
ijpds-7913	10	30	artificial	artificial	ADJ
ijpds-7913	10	31	intelligence	intelligence	NOUN
ijpds-7913	10	32	technologies	technology	NOUN
ijpds-7913	10	33	.	.	PUNCT
ijpds-7913	11	1	the	the	DET
ijpds-7913	11	2	ultimate	ultimate	ADJ
ijpds-7913	11	3	objective	objective	NOUN
ijpds-7913	11	4	of	of	ADP
ijpds-7913	11	5	the	the	DET
ijpds-7913	11	6	revolution	revolution	NOUN
ijpds-7913	11	7	in	in	ADP
ijpds-7913	11	8	model	model	NOUN
ijpds-7913	11	9	-	-	PUNCT
ijpds-7913	11	10	informed	inform	VERB
ijpds-7913	11	11	precision	precision	NOUN
ijpds-7913	11	12	dosage	dosage	NOUN
ijpds-7913	11	13	is	be	AUX
ijpds-7913	11	14	to	to	PART
ijpds-7913	11	15	establish	establish	VERB
ijpds-7913	11	16	individualized	individualize	VERB
ijpds-7913	11	17	,	,	PUNCT
ijpds-7913	11	18	patient	patient	ADJ
ijpds-7913	11	19	-	-	PUNCT
ijpds-7913	11	20	centric	centric	ADJ
ijpds-7913	11	21	therapies	therapy	NOUN
ijpds-7913	11	22	[	[	X
ijpds-7913	11	23	4	4	NUM
ijpds-7913	11	24	]	]	PUNCT
ijpds-7913	11	25	.	.	PUNCT
ijpds-7913	12	1	access	access	NOUN
ijpds-7913	12	2	this	this	DET
ijpds-7913	12	3	article	article	NOUN
ijpds-7913	12	4	online	online	ADV
ijpds-7913	12	5	received	receive	VERB
ijpds-7913	12	6	–	–	PUNCT
ijpds-7913	12	7	20th	20th	ADJ
ijpds-7913	12	8	april	april	PROPN
ijpds-7913	12	9	2025	2025	NUM
ijpds-7913	12	10	initial	initial	ADJ
ijpds-7913	12	11	review	review	NOUN
ijpds-7913	12	12	–	–	PUNCT
ijpds-7913	12	13	27th	27th	ADJ
ijpds-7913	12	14	april	april	PROPN
ijpds-7913	12	15	2025	2025	NUM
ijpds-7913	12	16	accepted	accept	VERB
ijpds-7913	12	17	–	–	PUNCT
ijpds-7913	12	18	15th	15th	NOUN
ijpds-7913	12	19	may	may	AUX
ijpds-7913	12	20	2025	2025	NUM
ijpds-7913	12	21	quick	quick	ADJ
ijpds-7913	12	22	response	response	NOUN
ijpds-7913	12	23	code	code	NOUN
ijpds-7913	12	24	tdm	tdm	NOUN
ijpds-7913	12	25	-	-	PUNCT
ijpds-7913	12	26	guided	guide	VERB
ijpds-7913	12	27	therapy	therapy	NOUN
ijpds-7913	12	28	is	be	AUX
ijpds-7913	12	29	particularly	particularly	ADV
ijpds-7913	12	30	beneficial	beneficial	ADJ
ijpds-7913	12	31	for	for	ADP
ijpds-7913	12	32	individuals	individual	NOUN
ijpds-7913	12	33	exhibiting	exhibit	VERB
ijpds-7913	12	34	significant	significant	ADJ
ijpds-7913	12	35	susceptibility	susceptibility	NOUN
ijpds-7913	12	36	and	and	CCONJ
ijpds-7913	12	37	unique	unique	ADJ
ijpds-7913	12	38	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	12	39	characteristics	characteristic	NOUN
ijpds-7913	12	40	regarding	regard	VERB
ijpds-7913	12	41	the	the	DET
ijpds-7913	12	42	supplied	supply	VERB
ijpds-7913	12	43	medicines	medicine	NOUN
ijpds-7913	12	44	.	.	PUNCT
ijpds-7913	13	1	examples	example	NOUN
ijpds-7913	13	2	encompass	encompass	VERB
ijpds-7913	13	3	cancer	cancer	NOUN
ijpds-7913	13	4	patients	patient	NOUN
ijpds-7913	13	5	,	,	PUNCT
ijpds-7913	13	6	seriously	seriously	ADV
ijpds-7913	13	7	ill	ill	ADJ
ijpds-7913	13	8	individuals	individual	NOUN
ijpds-7913	13	9	,	,	PUNCT
ijpds-7913	13	10	organ	organ	NOUN
ijpds-7913	13	11	transplant	transplant	NOUN
ijpds-7913	13	12	recipients	recipient	NOUN
ijpds-7913	13	13	,	,	PUNCT
ijpds-7913	13	14	and	and	CCONJ
ijpds-7913	13	15	people	people	NOUN
ijpds-7913	13	16	who	who	PRON
ijpds-7913	13	17	have	have	AUX
ijpds-7913	13	18	undergone	undergo	VERB
ijpds-7913	13	19	significant	significant	ADJ
ijpds-7913	13	20	surgical	surgical	ADJ
ijpds-7913	13	21	procedures	procedure	NOUN
ijpds-7913	13	22	.	.	PUNCT
ijpds-7913	14	1	moreover	moreover	ADV
ijpds-7913	14	2	,	,	PUNCT
ijpds-7913	14	3	specific	specific	ADJ
ijpds-7913	14	4	groups	group	NOUN
ijpds-7913	14	5	,	,	PUNCT
ijpds-7913	14	6	like	like	ADP
ijpds-7913	14	7	children	child	NOUN
ijpds-7913	14	8	and	and	CCONJ
ijpds-7913	14	9	those	those	PRON
ijpds-7913	14	10	with	with	ADP
ijpds-7913	14	11	obesity	obesity	NOUN
ijpds-7913	14	12	,	,	PUNCT
ijpds-7913	14	13	should	should	AUX
ijpds-7913	14	14	be	be	AUX
ijpds-7913	14	15	regarded	regard	VERB
ijpds-7913	14	16	as	as	ADP
ijpds-7913	14	17	subjects	subject	NOUN
ijpds-7913	14	18	for	for	ADP
ijpds-7913	14	19	specialized	specialized	ADJ
ijpds-7913	14	20	dosage	dosage	NOUN
ijpds-7913	14	21	procedures	procedure	NOUN
ijpds-7913	14	22	.	.	PUNCT
ijpds-7913	15	1	individuals	individual	NOUN
ijpds-7913	15	2	that	that	PRON
ijpds-7913	15	3	possess	possess	VERB
ijpds-7913	15	4	abnormal	abnormal	ADJ
ijpds-7913	15	5	biological	biological	ADJ
ijpds-7913	15	6	characteristics	characteristic	NOUN
ijpds-7913	15	7	,	,	PUNCT
ijpds-7913	15	8	such	such	ADJ
ijpds-7913	15	9	as	as	ADP
ijpds-7913	15	10	pharmacogenomic	pharmacogenomic	ADJ
ijpds-7913	15	11	mutations	mutation	NOUN
ijpds-7913	15	12	or	or	CCONJ
ijpds-7913	15	13	liver	liver	NOUN
ijpds-7913	15	14	diseases	disease	NOUN
ijpds-7913	15	15	,	,	PUNCT
ijpds-7913	15	16	need	need	VERB
ijpds-7913	15	17	personalized	personalized	ADJ
ijpds-7913	15	18	therapy	therapy	NOUN
ijpds-7913	15	19	strategies	strategy	NOUN
ijpds-7913	15	20	[	[	X
ijpds-7913	15	21	5	5	NUM
ijpds-7913	15	22	]	]	PUNCT
ijpds-7913	15	23	.	.	PUNCT
ijpds-7913	16	1	critical	critical	ADJ
ijpds-7913	16	2	illness	illness	NOUN
ijpds-7913	16	3	alters	alter	VERB
ijpds-7913	16	4	absorption	absorption	NOUN
ijpds-7913	16	5	,	,	PUNCT
ijpds-7913	16	6	distribution	distribution	NOUN
ijpds-7913	16	7	,	,	PUNCT
ijpds-7913	16	8	metabolism	metabolism	NOUN
ijpds-7913	16	9	,	,	PUNCT
ijpds-7913	16	10	and	and	CCONJ
ijpds-7913	16	11	excretion	excretion	NOUN
ijpds-7913	16	12	of	of	ADP
ijpds-7913	16	13	drugs	drug	NOUN
ijpds-7913	16	14	,	,	PUNCT
ijpds-7913	16	15	making	make	VERB
ijpds-7913	16	16	fixed	fix	VERB
ijpds-7913	16	17	dosing	dose	VERB
ijpds-7913	16	18	strategies	strategy	NOUN
ijpds-7913	16	19	inadequate	inadequate	ADJ
ijpds-7913	16	20	[	[	X
ijpds-7913	16	21	6	6	NUM
ijpds-7913	16	22	]	]	PUNCT
ijpds-7913	16	23	.	.	PUNCT
ijpds-7913	17	1	post	post	ADJ
ijpds-7913	17	2	-	-	ADJ
ijpds-7913	17	3	transplant	transplant	ADJ
ijpds-7913	17	4	,	,	PUNCT
ijpds-7913	17	5	maintaining	maintain	VERB
ijpds-7913	17	6	immunosuppressant	immunosuppressant	ADJ
ijpds-7913	17	7	levels	level	NOUN
ijpds-7913	17	8	is	be	AUX
ijpds-7913	17	9	crucial	crucial	ADJ
ijpds-7913	17	10	to	to	PART
ijpds-7913	17	11	prevent	prevent	VERB
ijpds-7913	17	12	rejection	rejection	NOUN
ijpds-7913	17	13	while	while	SCONJ
ijpds-7913	17	14	avoiding	avoid	VERB
ijpds-7913	17	15	toxicity	toxicity	NOUN
ijpds-7913	17	16	.	.	PUNCT
ijpds-7913	18	1	tdm	tdm	NOUN
ijpds-7913	18	2	enables	enable	VERB
ijpds-7913	18	3	dose	dose	NOUN
ijpds-7913	18	4	individualization	individualization	NOUN
ijpds-7913	18	5	based	base	VERB
ijpds-7913	18	6	on	on	ADP
ijpds-7913	18	7	plasma	plasma	NOUN
ijpds-7913	18	8	concentrations	concentration	NOUN
ijpds-7913	18	9	,	,	PUNCT
ijpds-7913	18	10	integrating	integrate	VERB
ijpds-7913	18	11	pk	pk	NOUN
ijpds-7913	18	12	/	/	SYM
ijpds-7913	18	13	pharmacodynamic	pharmacodynamic	ADJ
ijpds-7913	18	14	(	(	PUNCT
ijpds-7913	18	15	pd	pd	NOUN
ijpds-7913	18	16	)	)	PUNCT
ijpds-7913	18	17	principles	principle	NOUN
ijpds-7913	18	18	to	to	PART
ijpds-7913	18	19	optimize	optimize	VERB
ijpds-7913	18	20	therapy	therapy	NOUN
ijpds-7913	18	21	[	[	X
ijpds-7913	18	22	7	7	NUM
ijpds-7913	18	23	]	]	PUNCT
ijpds-7913	18	24	.	.	PUNCT
ijpds-7913	19	1	consequently	consequently	ADV
ijpds-7913	19	2	,	,	PUNCT
ijpds-7913	19	3	in	in	ADP
ijpds-7913	19	4	both	both	CCONJ
ijpds-7913	19	5	critical	critical	ADJ
ijpds-7913	19	6	care	care	NOUN
ijpds-7913	19	7	and	and	CCONJ
ijpds-7913	19	8	transplant	transplant	NOUN
ijpds-7913	19	9	medicine	medicine	NOUN
ijpds-7913	19	10	,	,	PUNCT
ijpds-7913	19	11	the	the	DET
ijpds-7913	19	12	clinical	clinical	ADJ
ijpds-7913	19	13	significance	significance	NOUN
ijpds-7913	19	14	of	of	ADP
ijpds-7913	19	15	therapeutic	therapeutic	ADJ
ijpds-7913	19	16	drug	drug	NOUN
ijpds-7913	19	17	monitoring	monitoring	NOUN
ijpds-7913	19	18	(	(	PUNCT
ijpds-7913	19	19	tdm	tdm	NOUN
ijpds-7913	19	20	)	)	PUNCT
ijpds-7913	19	21	is	be	AUX
ijpds-7913	19	22	highlighted	highlight	VERB
ijpds-7913	19	23	by	by	ADP
ijpds-7913	19	24	the	the	DET
ijpds-7913	19	25	administration	administration	NOUN
ijpds-7913	19	26	of	of	ADP
ijpds-7913	19	27	medications	medication	NOUN
ijpds-7913	19	28	with	with	ADP
ijpds-7913	19	29	a	a	DET
ijpds-7913	19	30	narrow	narrow	ADJ
ijpds-7913	19	31	therapeutic	therapeutic	ADJ
ijpds-7913	19	32	index	index	NOUN
ijpds-7913	19	33	,	,	PUNCT
ijpds-7913	19	34	including	include	VERB
ijpds-7913	19	35	aminoglycosides	aminoglycoside	NOUN
ijpds-7913	19	36	,	,	PUNCT
ijpds-7913	19	37	vancomycin	vancomycin	PROPN
ijpds-7913	19	38	,	,	PUNCT
ijpds-7913	19	39	tacrolimus	tacrolimus	NOUN
ijpds-7913	19	40	,	,	PUNCT
ijpds-7913	19	41	and	and	CCONJ
ijpds-7913	19	42	cyclosporine	cyclosporine	VERB
ijpds-7913	19	43	[	[	X
ijpds-7913	19	44	8	8	NUM
ijpds-7913	19	45	]	]	PUNCT
ijpds-7913	19	46	.	.	PUNCT
ijpds-7913	20	1	insufficient	insufficient	ADJ
ijpds-7913	20	2	exposure	exposure	NOUN
ijpds-7913	20	3	in	in	ADP
ijpds-7913	20	4	these	these	DET
ijpds-7913	20	5	patients	patient	NOUN
ijpds-7913	20	6	may	may	AUX
ijpds-7913	20	7	lead	lead	VERB
ijpds-7913	20	8	to	to	ADP
ijpds-7913	20	9	therapeutic	therapeutic	ADJ
ijpds-7913	20	10	failure	failure	NOUN
ijpds-7913	20	11	,	,	PUNCT
ijpds-7913	20	12	the	the	DET
ijpds-7913	20	13	development	development	NOUN
ijpds-7913	20	14	of	of	ADP
ijpds-7913	20	15	antimicrobial	antimicrobial	ADJ
ijpds-7913	20	16	resistance	resistance	NOUN
ijpds-7913	20	17	,	,	PUNCT
ijpds-7913	20	18	and	and	CCONJ
ijpds-7913	20	19	graft	graft	NOUN
ijpds-7913	20	20	rejection	rejection	NOUN
ijpds-7913	20	21	,	,	PUNCT
ijpds-7913	20	22	while	while	SCONJ
ijpds-7913	20	23	concentrations	concentration	NOUN
ijpds-7913	20	24	exceeding	exceed	VERB
ijpds-7913	20	25	the	the	DET
ijpds-7913	20	26	sub	sub	ADJ
ijpds-7913	20	27	-	-	ADJ
ijpds-7913	20	28	therapeutic	therapeutic	ADJ
ijpds-7913	20	29	threshold	threshold	NOUN
ijpds-7913	20	30	are	be	AUX
ijpds-7913	20	31	linked	link	VERB
ijpds-7913	20	32	to	to	ADP
ijpds-7913	20	33	severe	severe	ADJ
ijpds-7913	20	34	toxicities	toxicity	NOUN
ijpds-7913	20	35	,	,	PUNCT
ijpds-7913	20	36	including	include	VERB
ijpds-7913	20	37	nephrotoxicity	nephrotoxicity	NOUN
ijpds-7913	20	38	,	,	PUNCT
ijpds-7913	20	39	hepatotoxicity	hepatotoxicity	NOUN
ijpds-7913	20	40	,	,	PUNCT
ijpds-7913	20	41	and	and	CCONJ
ijpds-7913	20	42	neurotoxicity	neurotoxicity	NOUN
ijpds-7913	20	43	,	,	PUNCT
ijpds-7913	20	44	_	_	PUNCT
ijpds-7913	21	1	_	_	PUNCT
ijpds-7913	22	1	_	_	PUNCT
ijpds-7913	23	1	_	_	PUNCT
ijpds-7913	24	1	_	_	PUNCT
ijpds-7913	25	1	_	_	PUNCT
ijpds-7913	26	1	_	_	PUNCT
ijpds-7913	27	1	_	_	PUNCT
ijpds-7913	28	1	_	_	PUNCT
ijpds-7913	29	1	_	_	PUNCT
ijpds-7913	30	1	_	_	PUNCT
ijpds-7913	31	1	_	_	PUNCT
ijpds-7913	32	1	_	_	PUNCT
ijpds-7913	33	1	_	_	PUNCT
ijpds-7913	34	1	_	_	PUNCT
ijpds-7913	35	1	_	_	PUNCT
ijpds-7913	36	1	_	_	PUNCT
ijpds-7913	37	1	_	_	PUNCT
ijpds-7913	38	1	_	_	PUNCT
ijpds-7913	39	1	_	_	PUNCT
ijpds-7913	40	1	_	_	PUNCT
ijpds-7913	41	1	_	_	PUNCT
ijpds-7913	42	1	_	_	PUNCT
ijpds-7913	43	1	_	_	PUNCT
ijpds-7913	44	1	_	_	PUNCT
ijpds-7913	45	1	_	_	PUNCT
ijpds-7913	46	1	_	_	PUNCT
ijpds-7913	47	1	_	_	PUNCT
ijpds-7913	48	1	_	_	PUNCT
ijpds-7913	49	1	_	_	PUNCT
ijpds-7913	50	1	_	_	PUNCT
ijpds-7913	51	1	_	_	PUNCT
ijpds-7913	52	1	_	_	PUNCT
ijpds-7913	53	1	_	_	PUNCT
ijpds-7913	54	1	_	_	PUNCT
ijpds-7913	55	1	_	_	PUNCT
ijpds-7913	56	1	_	_	PUNCT
ijpds-7913	57	1	_	_	PUNCT
ijpds-7913	58	1	_	_	PUNCT
ijpds-7913	59	1	_	_	PUNCT
ijpds-7913	60	1	_	_	PUNCT
ijpds-7913	61	1	_	_	PUNCT
ijpds-7913	62	1	_	_	PUNCT
ijpds-7913	63	1	_	_	PUNCT
ijpds-7913	64	1	_	_	PUNCT
ijpds-7913	65	1	_	_	PUNCT
ijpds-7913	66	1	_	_	PUNCT
ijpds-7913	67	1	_	_	PUNCT
ijpds-7913	68	1	_	_	PUNCT
ijpds-7913	69	1	_	_	PUNCT
ijpds-7913	69	2	correspondence	correspondence	NOUN
ijpds-7913	69	3	to	to	ADP
ijpds-7913	69	4	:	:	PUNCT
ijpds-7913	69	5	dr	dr	PROPN
ijpds-7913	69	6	.	.	PROPN
ijpds-7913	69	7	rashmi	rashmi	PROPN
ijpds-7913	69	8	agrawal	agrawal	PROPN
ijpds-7913	69	9	.	.	PUNCT
ijpds-7913	70	1	devmata	devmata	PROPN
ijpds-7913	70	2	hospital	hospital	NOUN
ijpds-7913	70	3	,	,	PUNCT
ijpds-7913	70	4	bhopal	bhopal	PROPN
ijpds-7913	70	5	,	,	PUNCT
ijpds-7913	70	6	madhya	madhya	PROPN
ijpds-7913	70	7	pradesh	pradesh	PROPN
ijpds-7913	70	8	,	,	PUNCT
ijpds-7913	70	9	india	india	PROPN
ijpds-7913	70	10	.	.	PUNCT
ijpds-7913	70	11	email	email	NOUN
ijpds-7913	70	12	:	:	PUNCT
ijpds-7913	71	1	atharvapub@gmail.com	atharvapub@gmail.com	X
ijpds-7913	71	2	t	t	PROPN
ijpds-7913	71	3	mailto:atharvapub@gmail.com	mailto:atharvapub@gmail.com	X
ijpds-7913	71	4	agrawal	agrawal	PROPN
ijpds-7913	71	5	therapeutic	therapeutic	ADJ
ijpds-7913	71	6	drug	drug	NOUN
ijpds-7913	71	7	monitoring	monitoring	NOUN
ijpds-7913	71	8	in	in	ADP
ijpds-7913	71	9	critical	critical	ADJ
ijpds-7913	71	10	care	care	NOUN
ijpds-7913	71	11	and	and	CCONJ
ijpds-7913	71	12	transplants	transplant	NOUN
ijpds-7913	71	13	online	online	ADJ
ijpds-7913	71	14	first	first	PROPN
ijpds-7913	71	15	indian	indian	PROPN
ijpds-7913	71	16	j	j	PROPN
ijpds-7913	71	17	pharm	pharm	PROPN
ijpds-7913	71	18	drug	drug	PROPN
ijpds-7913	71	19	studies	study	NOUN
ijpds-7913	71	20	|	|	ADV
ijpds-7913	71	21	2	2	NUM
ijpds-7913	71	22	culminating	culminate	VERB
ijpds-7913	71	23	in	in	ADP
ijpds-7913	71	24	end	end	NOUN
ijpds-7913	71	25	-	-	PUNCT
ijpds-7913	71	26	stage	stage	NOUN
ijpds-7913	71	27	organ	organ	NOUN
ijpds-7913	71	28	failure	failure	NOUN
ijpds-7913	71	29	[	[	X
ijpds-7913	71	30	9	9	NUM
ijpds-7913	71	31	]	]	PUNCT
ijpds-7913	71	32	.	.	PUNCT
ijpds-7913	72	1	the	the	DET
ijpds-7913	72	2	significant	significant	ADJ
ijpds-7913	72	3	interand	interand	NOUN
ijpds-7913	72	4	intra	intra	ADJ
ijpds-7913	72	5	-	-	ADJ
ijpds-7913	72	6	patient	patient	ADJ
ijpds-7913	72	7	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	72	8	heterogeneity	heterogeneity	NOUN
ijpds-7913	72	9	in	in	ADP
ijpds-7913	72	10	these	these	DET
ijpds-7913	72	11	groups	group	NOUN
ijpds-7913	72	12	is	be	AUX
ijpds-7913	72	13	affected	affect	VERB
ijpds-7913	72	14	by	by	ADP
ijpds-7913	72	15	variables	variable	NOUN
ijpds-7913	72	16	including	include	VERB
ijpds-7913	72	17	organ	organ	NOUN
ijpds-7913	72	18	failure	failure	NOUN
ijpds-7913	72	19	,	,	PUNCT
ijpds-7913	72	20	sepsis	sepsis	NOUN
ijpds-7913	72	21	,	,	PUNCT
ijpds-7913	72	22	polypharmacy	polypharmacy	NOUN
ijpds-7913	72	23	,	,	PUNCT
ijpds-7913	72	24	drug	drug	NOUN
ijpds-7913	72	25	-	-	PUNCT
ijpds-7913	72	26	drug	drug	NOUN
ijpds-7913	72	27	and	and	CCONJ
ijpds-7913	72	28	drug	drug	NOUN
ijpds-7913	72	29	-	-	PUNCT
ijpds-7913	72	30	disease	disease	NOUN
ijpds-7913	72	31	interactions	interaction	NOUN
ijpds-7913	72	32	,	,	PUNCT
ijpds-7913	72	33	and	and	CCONJ
ijpds-7913	72	34	genetic	genetic	ADJ
ijpds-7913	72	35	variants	variant	NOUN
ijpds-7913	72	36	that	that	PRON
ijpds-7913	72	37	influence	influence	VERB
ijpds-7913	72	38	drug	drug	NOUN
ijpds-7913	72	39	metabolism	metabolism	NOUN
ijpds-7913	72	40	.	.	PUNCT
ijpds-7913	73	1	as	as	ADP
ijpds-7913	73	2	a	a	DET
ijpds-7913	73	3	result	result	NOUN
ijpds-7913	73	4	,	,	PUNCT
ijpds-7913	73	5	personalized	personalize	VERB
ijpds-7913	73	6	concentrationguided	concentrationguide	VERB
ijpds-7913	73	7	treatment	treatment	NOUN
ijpds-7913	73	8	is	be	AUX
ijpds-7913	73	9	becoming	becoming	AUX
ijpds-7913	73	10	acknowledged	acknowledge	VERB
ijpds-7913	73	11	as	as	ADP
ijpds-7913	73	12	a	a	DET
ijpds-7913	73	13	fundamental	fundamental	ADJ
ijpds-7913	73	14	aspect	aspect	NOUN
ijpds-7913	73	15	of	of	ADP
ijpds-7913	73	16	precision	precision	NOUN
ijpds-7913	73	17	medicine	medicine	NOUN
ijpds-7913	73	18	in	in	ADP
ijpds-7913	73	19	many	many	ADJ
ijpds-7913	73	20	contexts	context	NOUN
ijpds-7913	73	21	[	[	X
ijpds-7913	73	22	10	10	NUM
ijpds-7913	73	23	]	]	PUNCT
ijpds-7913	73	24	.	.	PUNCT
ijpds-7913	74	1	by	by	ADP
ijpds-7913	74	2	sustaining	sustain	VERB
ijpds-7913	74	3	medication	medication	NOUN
ijpds-7913	74	4	concentrations	concentration	NOUN
ijpds-7913	74	5	within	within	ADP
ijpds-7913	74	6	specified	specified	ADJ
ijpds-7913	74	7	therapeutic	therapeutic	ADJ
ijpds-7913	74	8	ranges	range	NOUN
ijpds-7913	74	9	,	,	PUNCT
ijpds-7913	74	10	therapeutic	therapeutic	ADJ
ijpds-7913	74	11	drug	drug	NOUN
ijpds-7913	74	12	monitoring	monitoring	NOUN
ijpds-7913	74	13	(	(	PUNCT
ijpds-7913	74	14	tdm	tdm	NOUN
ijpds-7913	74	15	)	)	PUNCT
ijpds-7913	74	16	boosts	boost	VERB
ijpds-7913	74	17	clinical	clinical	ADJ
ijpds-7913	74	18	efficacy	efficacy	NOUN
ijpds-7913	74	19	,	,	PUNCT
ijpds-7913	74	20	mitigates	mitigate	VERB
ijpds-7913	74	21	adverse	adverse	ADJ
ijpds-7913	74	22	drug	drug	NOUN
ijpds-7913	74	23	reactions	reaction	NOUN
ijpds-7913	74	24	,	,	PUNCT
ijpds-7913	74	25	shortens	shorten	VERB
ijpds-7913	74	26	hospital	hospital	NOUN
ijpds-7913	74	27	stays	stay	NOUN
ijpds-7913	74	28	,	,	PUNCT
ijpds-7913	74	29	and	and	CCONJ
ijpds-7913	74	30	improves	improve	VERB
ijpds-7913	74	31	overall	overall	ADJ
ijpds-7913	74	32	cost	cost	NOUN
ijpds-7913	74	33	-	-	PUNCT
ijpds-7913	74	34	effectiveness	effectiveness	NOUN
ijpds-7913	74	35	[	[	X
ijpds-7913	74	36	11	11	NUM
ijpds-7913	74	37	]	]	PUNCT
ijpds-7913	74	38	.	.	PUNCT
ijpds-7913	75	1	therefore	therefore	ADV
ijpds-7913	75	2	,	,	PUNCT
ijpds-7913	75	3	incorporating	incorporate	VERB
ijpds-7913	75	4	tdm	tdm	NOUN
ijpds-7913	75	5	into	into	ADP
ijpds-7913	75	6	standard	standard	ADJ
ijpds-7913	75	7	clinical	clinical	ADJ
ijpds-7913	75	8	practice	practice	NOUN
ijpds-7913	75	9	is	be	AUX
ijpds-7913	75	10	essential	essential	ADJ
ijpds-7913	75	11	for	for	ADP
ijpds-7913	75	12	enhancing	enhance	VERB
ijpds-7913	75	13	patient	patient	ADJ
ijpds-7913	75	14	outcomes	outcome	NOUN
ijpds-7913	75	15	in	in	ADP
ijpds-7913	75	16	critically	critically	ADV
ijpds-7913	75	17	sick	sick	ADJ
ijpds-7913	75	18	and	and	CCONJ
ijpds-7913	75	19	transplant	transplant	NOUN
ijpds-7913	75	20	groups	group	NOUN
ijpds-7913	75	21	.	.	PUNCT
ijpds-7913	76	1	i.	i.	PROPN
ijpds-7913	76	2	tdm	tdm	PROPN
ijpds-7913	76	3	in	in	ADP
ijpds-7913	76	4	critical	critical	ADJ
ijpds-7913	76	5	care	care	NOUN
ijpds-7913	76	6	in	in	ADP
ijpds-7913	76	7	the	the	DET
ijpds-7913	76	8	intensive	intensive	ADJ
ijpds-7913	76	9	care	care	NOUN
ijpds-7913	76	10	unit	unit	NOUN
ijpds-7913	76	11	(	(	PUNCT
ijpds-7913	76	12	icu	icu	PROPN
ijpds-7913	76	13	)	)	PUNCT
ijpds-7913	76	14	,	,	PUNCT
ijpds-7913	76	15	where	where	SCONJ
ijpds-7913	76	16	patients	patient	NOUN
ijpds-7913	76	17	frequently	frequently	ADV
ijpds-7913	76	18	undergo	undergo	VERB
ijpds-7913	76	19	significant	significant	ADJ
ijpds-7913	76	20	physiological	physiological	ADJ
ijpds-7913	76	21	alterations	alteration	NOUN
ijpds-7913	76	22	,	,	PUNCT
ijpds-7913	76	23	therapeutic	therapeutic	ADJ
ijpds-7913	76	24	drug	drug	NOUN
ijpds-7913	76	25	monitoring	monitoring	NOUN
ijpds-7913	76	26	(	(	PUNCT
ijpds-7913	76	27	tdm	tdm	X
ijpds-7913	76	28	)	)	PUNCT
ijpds-7913	76	29	plays	play	VERB
ijpds-7913	76	30	a	a	DET
ijpds-7913	76	31	crucial	crucial	ADJ
ijpds-7913	76	32	role	role	NOUN
ijpds-7913	76	33	in	in	ADP
ijpds-7913	76	34	directing	direct	VERB
ijpds-7913	76	35	pharmacotherapy	pharmacotherapy	NOUN
ijpds-7913	76	36	.	.	PUNCT
ijpds-7913	77	1	critical	critical	ADJ
ijpds-7913	77	2	illness	illness	NOUN
ijpds-7913	77	3	is	be	AUX
ijpds-7913	77	4	linked	link	VERB
ijpds-7913	77	5	to	to	ADP
ijpds-7913	77	6	hemodynamic	hemodynamic	ADJ
ijpds-7913	77	7	instability	instability	NOUN
ijpds-7913	77	8	,	,	PUNCT
ijpds-7913	77	9	hypoalbuminemia	hypoalbuminemia	ADV
ijpds-7913	77	10	,	,	PUNCT
ijpds-7913	77	11	disrupted	disrupt	VERB
ijpds-7913	77	12	fluid	fluid	ADJ
ijpds-7913	77	13	balance	balance	NOUN
ijpds-7913	77	14	,	,	PUNCT
ijpds-7913	77	15	increased	increase	VERB
ijpds-7913	77	16	renal	renal	ADJ
ijpds-7913	77	17	clearance	clearance	NOUN
ijpds-7913	77	18	,	,	PUNCT
ijpds-7913	77	19	and	and	CCONJ
ijpds-7913	77	20	organ	organ	NOUN
ijpds-7913	77	21	failure	failure	NOUN
ijpds-7913	77	22	,	,	PUNCT
ijpds-7913	77	23	all	all	PRON
ijpds-7913	77	24	of	of	ADP
ijpds-7913	77	25	which	which	PRON
ijpds-7913	77	26	affect	affect	VERB
ijpds-7913	77	27	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	77	28	(	(	PUNCT
ijpds-7913	77	29	pk	pk	NOUN
ijpds-7913	77	30	)	)	PUNCT
ijpds-7913	77	31	and	and	CCONJ
ijpds-7913	77	32	pharmacodynamics	pharmacodynamic	NOUN
ijpds-7913	77	33	(	(	PUNCT
ijpds-7913	77	34	pd	pd	NOUN
ijpds-7913	77	35	)	)	PUNCT
ijpds-7913	78	1	[	[	X
ijpds-7913	78	2	12	12	NUM
ijpds-7913	78	3	]	]	PUNCT
ijpds-7913	78	4	.	.	PUNCT
ijpds-7913	79	1	these	these	DET
ijpds-7913	79	2	alterations	alteration	NOUN
ijpds-7913	79	3	render	render	VERB
ijpds-7913	79	4	traditional	traditional	ADJ
ijpds-7913	79	5	dosage	dosage	NOUN
ijpds-7913	79	6	techniques	technique	NOUN
ijpds-7913	79	7	insufficient	insufficient	ADJ
ijpds-7913	79	8	,	,	PUNCT
ijpds-7913	79	9	necessitating	necessitate	VERB
ijpds-7913	79	10	individualized	individualized	ADJ
ijpds-7913	79	11	dosing	dosing	NOUN
ijpds-7913	79	12	informed	inform	VERB
ijpds-7913	79	13	by	by	ADP
ijpds-7913	79	14	therapeutic	therapeutic	ADJ
ijpds-7913	79	15	drug	drug	NOUN
ijpds-7913	79	16	monitoring	monitoring	NOUN
ijpds-7913	79	17	as	as	ADP
ijpds-7913	79	18	a	a	DET
ijpds-7913	79	19	crucial	crucial	ADJ
ijpds-7913	79	20	element	element	NOUN
ijpds-7913	79	21	of	of	ADP
ijpds-7913	79	22	critical	critical	ADJ
ijpds-7913	79	23	care	care	NOUN
ijpds-7913	79	24	treatment	treatment	NOUN
ijpds-7913	79	25	.	.	PUNCT
ijpds-7913	80	1	the	the	DET
ijpds-7913	80	2	icu	icu	PROPN
ijpds-7913	80	3	population	population	NOUN
ijpds-7913	80	4	is	be	AUX
ijpds-7913	80	5	particularly	particularly	ADV
ijpds-7913	80	6	susceptible	susceptible	ADJ
ijpds-7913	80	7	owing	owe	VERB
ijpds-7913	80	8	to	to	ADP
ijpds-7913	80	9	the	the	DET
ijpds-7913	80	10	severity	severity	NOUN
ijpds-7913	80	11	of	of	ADP
ijpds-7913	80	12	illnesses	illness	NOUN
ijpds-7913	80	13	,	,	PUNCT
ijpds-7913	80	14	the	the	DET
ijpds-7913	80	15	frequent	frequent	ADJ
ijpds-7913	80	16	administration	administration	NOUN
ijpds-7913	80	17	of	of	ADP
ijpds-7913	80	18	lifesustaining	lifesustaine	VERB
ijpds-7913	80	19	treatments	treatment	NOUN
ijpds-7913	80	20	,	,	PUNCT
ijpds-7913	80	21	and	and	CCONJ
ijpds-7913	80	22	the	the	DET
ijpds-7913	80	23	prevalence	prevalence	NOUN
ijpds-7913	80	24	of	of	ADP
ijpds-7913	80	25	polypharmacy	polypharmacy	NOUN
ijpds-7913	80	26	[	[	X
ijpds-7913	80	27	13	13	NUM
ijpds-7913	80	28	]	]	PUNCT
ijpds-7913	80	29	.	.	PUNCT
ijpds-7913	81	1	extracorporeal	extracorporeal	NOUN
ijpds-7913	81	2	techniques	technique	NOUN
ijpds-7913	81	3	,	,	PUNCT
ijpds-7913	81	4	including	include	VERB
ijpds-7913	81	5	continuous	continuous	ADJ
ijpds-7913	81	6	renal	renal	ADJ
ijpds-7913	81	7	replacement	replacement	NOUN
ijpds-7913	81	8	therapy	therapy	NOUN
ijpds-7913	81	9	(	(	PUNCT
ijpds-7913	81	10	crrt	crrt	NOUN
ijpds-7913	81	11	)	)	PUNCT
ijpds-7913	81	12	and	and	CCONJ
ijpds-7913	81	13	extracorporeal	extracorporeal	ADJ
ijpds-7913	81	14	membrane	membrane	NOUN
ijpds-7913	81	15	oxygenation	oxygenation	NOUN
ijpds-7913	81	16	(	(	PUNCT
ijpds-7913	81	17	ecmo	ecmo	NOUN
ijpds-7913	81	18	)	)	PUNCT
ijpds-7913	81	19	,	,	PUNCT
ijpds-7913	81	20	significantly	significantly	ADV
ijpds-7913	81	21	modify	modify	VERB
ijpds-7913	81	22	medication	medication	NOUN
ijpds-7913	81	23	distribution	distribution	NOUN
ijpds-7913	81	24	and	and	CCONJ
ijpds-7913	81	25	clearance	clearance	NOUN
ijpds-7913	81	26	,	,	PUNCT
ijpds-7913	81	27	resulting	result	VERB
ijpds-7913	81	28	in	in	ADP
ijpds-7913	81	29	sub	sub	ADJ
ijpds-7913	81	30	-	-	ADJ
ijpds-7913	81	31	therapeutic	therapeutic	ADJ
ijpds-7913	81	32	exposure	exposure	NOUN
ijpds-7913	81	33	or	or	CCONJ
ijpds-7913	81	34	drug	drug	NOUN
ijpds-7913	81	35	toxicity	toxicity	NOUN
ijpds-7913	81	36	when	when	SCONJ
ijpds-7913	81	37	traditional	traditional	ADJ
ijpds-7913	81	38	dosing	dosing	ADJ
ijpds-7913	81	39	protocols	protocol	NOUN
ijpds-7913	81	40	are	be	AUX
ijpds-7913	81	41	utilized	utilize	VERB
ijpds-7913	81	42	[	[	PUNCT
ijpds-7913	81	43	14	14	NUM
ijpds-7913	81	44	]	]	PUNCT
ijpds-7913	81	45	.	.	PUNCT
ijpds-7913	82	1	tdm	tdm	PROPN
ijpds-7913	82	2	facilitates	facilitate	VERB
ijpds-7913	82	3	precise	precise	ADJ
ijpds-7913	82	4	dosage	dosage	NOUN
ijpds-7913	82	5	by	by	ADP
ijpds-7913	82	6	guaranteeing	guarantee	VERB
ijpds-7913	82	7	goal	goal	NOUN
ijpds-7913	82	8	attainment	attainment	NOUN
ijpds-7913	82	9	,	,	PUNCT
ijpds-7913	82	10	particularly	particularly	ADV
ijpds-7913	82	11	for	for	ADP
ijpds-7913	82	12	medications	medication	NOUN
ijpds-7913	82	13	with	with	ADP
ijpds-7913	82	14	narrow	narrow	ADJ
ijpds-7913	82	15	therapeutic	therapeutic	ADJ
ijpds-7913	82	16	indices	index	NOUN
ijpds-7913	82	17	or	or	CCONJ
ijpds-7913	82	18	those	those	DET
ijpds-7913	82	19	necessitating	necessitate	VERB
ijpds-7913	82	20	specific	specific	ADJ
ijpds-7913	82	21	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	82	22	/	/	SYM
ijpds-7913	82	23	pharmacodynamic	pharmacodynamic	ADJ
ijpds-7913	82	24	thresholds	threshold	NOUN
ijpds-7913	82	25	for	for	ADP
ijpds-7913	82	26	effectiveness	effectiveness	NOUN
ijpds-7913	82	27	[	[	X
ijpds-7913	82	28	15	15	NUM
ijpds-7913	82	29	]	]	PUNCT
ijpds-7913	82	30	.	.	PUNCT
ijpds-7913	83	1	this	this	PRON
ijpds-7913	83	2	is	be	AUX
ijpds-7913	83	3	especially	especially	ADV
ijpds-7913	83	4	pertinent	pertinent	ADJ
ijpds-7913	83	5	for	for	ADP
ijpds-7913	83	6	antimicrobials	antimicrobial	NOUN
ijpds-7913	83	7	,	,	PUNCT
ijpds-7913	83	8	since	since	SCONJ
ijpds-7913	83	9	under	under	ADV
ijpds-7913	83	10	-	-	PUNCT
ijpds-7913	83	11	dosing	dosing	NOUN
ijpds-7913	83	12	can	can	AUX
ijpds-7913	83	13	lead	lead	VERB
ijpds-7913	83	14	to	to	ADP
ijpds-7913	83	15	therapeutic	therapeutic	ADJ
ijpds-7913	83	16	failure	failure	NOUN
ijpds-7913	83	17	and	and	CCONJ
ijpds-7913	83	18	antimicrobial	antimicrobial	ADJ
ijpds-7913	83	19	resistance	resistance	NOUN
ijpds-7913	83	20	,	,	PUNCT
ijpds-7913	83	21	whilst	whilst	SCONJ
ijpds-7913	83	22	overdoing	overdo	VERB
ijpds-7913	83	23	heightens	heighten	NOUN
ijpds-7913	83	24	toxicity	toxicity	NOUN
ijpds-7913	83	25	concerns	concern	NOUN
ijpds-7913	83	26	[	[	X
ijpds-7913	83	27	16	16	NUM
ijpds-7913	83	28	]	]	PUNCT
ijpds-7913	83	29	.	.	PUNCT
ijpds-7913	84	1	a.	a.	PROPN
ijpds-7913	84	2	antimicrobial	antimicrobial	PROPN
ijpds-7913	84	3	tdm	tdm	PROPN
ijpds-7913	84	4	β	β	X
ijpds-7913	84	5	-	-	NOUN
ijpds-7913	84	6	lactams	lactam	NOUN
ijpds-7913	84	7	are	be	AUX
ijpds-7913	84	8	the	the	DET
ijpds-7913	84	9	most	most	ADV
ijpds-7913	84	10	extensively	extensively	ADV
ijpds-7913	84	11	researched	research	VERB
ijpds-7913	84	12	antimicrobials	antimicrobial	NOUN
ijpds-7913	84	13	in	in	ADP
ijpds-7913	84	14	critical	critical	ADJ
ijpds-7913	84	15	care	care	NOUN
ijpds-7913	84	16	environments	environment	NOUN
ijpds-7913	84	17	.	.	PUNCT
ijpds-7913	85	1	these	these	DET
ijpds-7913	85	2	time	time	NOUN
ijpds-7913	85	3	-	-	PUNCT
ijpds-7913	85	4	dependent	dependent	ADJ
ijpds-7913	85	5	medicines	medicine	NOUN
ijpds-7913	85	6	exhibit	exhibit	VERB
ijpds-7913	85	7	significant	significant	ADJ
ijpds-7913	85	8	interpatient	interpatient	ADJ
ijpds-7913	85	9	variability	variability	NOUN
ijpds-7913	85	10	in	in	ADP
ijpds-7913	85	11	critically	critically	ADV
ijpds-7913	85	12	sick	sick	ADJ
ijpds-7913	85	13	patients	patient	NOUN
ijpds-7913	85	14	;	;	PUNCT
ijpds-7913	85	15	therapeutic	therapeutic	ADJ
ijpds-7913	85	16	drug	drug	NOUN
ijpds-7913	85	17	monitoring	monitoring	NOUN
ijpds-7913	85	18	(	(	PUNCT
ijpds-7913	85	19	tdm	tdm	NOUN
ijpds-7913	85	20	)	)	PUNCT
ijpds-7913	85	21	paired	pair	VERB
ijpds-7913	85	22	with	with	ADP
ijpds-7913	85	23	longer	long	ADJ
ijpds-7913	85	24	or	or	CCONJ
ijpds-7913	85	25	continuous	continuous	ADJ
ijpds-7913	85	26	infusions	infusion	NOUN
ijpds-7913	85	27	has	have	AUX
ijpds-7913	85	28	demonstrated	demonstrate	VERB
ijpds-7913	85	29	enhancement	enhancement	NOUN
ijpds-7913	85	30	in	in	ADP
ijpds-7913	85	31	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	85	32	/	/	SYM
ijpds-7913	85	33	pharmacodynamic	pharmacodynamic	ADJ
ijpds-7913	85	34	(	(	PUNCT
ijpds-7913	85	35	pk	pk	NOUN
ijpds-7913	85	36	/	/	SYM
ijpds-7913	85	37	pd	pd	NOUN
ijpds-7913	85	38	)	)	PUNCT
ijpds-7913	85	39	goal	goal	NOUN
ijpds-7913	85	40	achievement	achievement	NOUN
ijpds-7913	85	41	and	and	CCONJ
ijpds-7913	85	42	perhaps	perhaps	ADV
ijpds-7913	85	43	improved	improve	VERB
ijpds-7913	85	44	clinical	clinical	ADJ
ijpds-7913	85	45	outcomes	outcome	NOUN
ijpds-7913	85	46	[	[	X
ijpds-7913	85	47	17	17	NUM
ijpds-7913	85	48	]	]	PUNCT
ijpds-7913	85	49	.	.	PUNCT
ijpds-7913	86	1	similarly	similarly	ADV
ijpds-7913	86	2	,	,	PUNCT
ijpds-7913	86	3	vancomycin	vancomycin	PROPN
ijpds-7913	86	4	,	,	PUNCT
ijpds-7913	86	5	aminoglycosides	aminoglycoside	NOUN
ijpds-7913	86	6	,	,	PUNCT
ijpds-7913	86	7	and	and	CCONJ
ijpds-7913	86	8	colistin	colistin	VERB
ijpds-7913	86	9	necessitate	necessitate	ADJ
ijpds-7913	86	10	vigilant	vigilant	ADJ
ijpds-7913	86	11	monitoring	monitoring	NOUN
ijpds-7913	86	12	owing	owe	VERB
ijpds-7913	86	13	to	to	ADP
ijpds-7913	86	14	their	their	PRON
ijpds-7913	86	15	limited	limited	ADJ
ijpds-7913	86	16	therapeutic	therapeutic	ADJ
ijpds-7913	86	17	ranges	range	NOUN
ijpds-7913	86	18	and	and	CCONJ
ijpds-7913	86	19	possible	possible	ADJ
ijpds-7913	86	20	nephrotoxicity	nephrotoxicity	NOUN
ijpds-7913	86	21	[	[	X
ijpds-7913	86	22	18	18	NUM
ijpds-7913	86	23	]	]	PUNCT
ijpds-7913	86	24	.	.	PUNCT
ijpds-7913	87	1	antifungals	antifungal	NOUN
ijpds-7913	87	2	like	like	ADP
ijpds-7913	87	3	voriconazole	voriconazole	NOUN
ijpds-7913	87	4	and	and	CCONJ
ijpds-7913	87	5	posaconazole	posaconazole	NOUN
ijpds-7913	87	6	benefit	benefit	NOUN
ijpds-7913	87	7	from	from	ADP
ijpds-7913	87	8	therapeutic	therapeutic	ADJ
ijpds-7913	87	9	drug	drug	NOUN
ijpds-7913	87	10	monitoring	monitoring	NOUN
ijpds-7913	87	11	due	due	ADP
ijpds-7913	87	12	to	to	ADP
ijpds-7913	87	13	their	their	PRON
ijpds-7913	87	14	variable	variable	ADJ
ijpds-7913	87	15	bioavailability	bioavailability	NOUN
ijpds-7913	87	16	and	and	CCONJ
ijpds-7913	87	17	considerable	considerable	ADJ
ijpds-7913	87	18	inter	inter	ADJ
ijpds-7913	87	19	-	-	ADJ
ijpds-7913	87	20	individual	individual	ADJ
ijpds-7913	87	21	variability	variability	NOUN
ijpds-7913	87	22	[	[	X
ijpds-7913	87	23	19	19	NUM
ijpds-7913	87	24	]	]	PUNCT
ijpds-7913	87	25	.	.	PUNCT
ijpds-7913	88	1	evidence	evidence	NOUN
ijpds-7913	88	2	increasingly	increasingly	ADV
ijpds-7913	88	3	advocates	advocate	VERB
ijpds-7913	88	4	for	for	ADP
ijpds-7913	88	5	the	the	DET
ijpds-7913	88	6	widespread	widespread	ADJ
ijpds-7913	88	7	application	application	NOUN
ijpds-7913	88	8	of	of	ADP
ijpds-7913	88	9	antimicrobial	antimicrobial	ADJ
ijpds-7913	88	10	therapeutic	therapeutic	ADJ
ijpds-7913	88	11	drug	drug	NOUN
ijpds-7913	88	12	monitoring	monitoring	NOUN
ijpds-7913	88	13	(	(	PUNCT
ijpds-7913	88	14	tdm	tdm	NOUN
ijpds-7913	88	15	)	)	PUNCT
ijpds-7913	88	16	in	in	ADP
ijpds-7913	88	17	intensive	intensive	ADJ
ijpds-7913	88	18	care	care	NOUN
ijpds-7913	88	19	unit	unit	NOUN
ijpds-7913	88	20	(	(	PUNCT
ijpds-7913	88	21	icu	icu	PROPN
ijpds-7913	88	22	)	)	PUNCT
ijpds-7913	88	23	treatment	treatment	NOUN
ijpds-7913	88	24	,	,	PUNCT
ijpds-7913	88	25	bolstered	bolster	VERB
ijpds-7913	88	26	by	by	ADP
ijpds-7913	88	27	recent	recent	ADJ
ijpds-7913	88	28	consensus	consensus	NOUN
ijpds-7913	88	29	recommendations	recommendation	NOUN
ijpds-7913	88	30	from	from	ADP
ijpds-7913	88	31	the	the	DET
ijpds-7913	88	32	european	european	ADJ
ijpds-7913	88	33	society	society	NOUN
ijpds-7913	88	34	of	of	ADP
ijpds-7913	88	35	intensive	intensive	ADJ
ijpds-7913	88	36	care	care	NOUN
ijpds-7913	88	37	medicine	medicine	NOUN
ijpds-7913	88	38	(	(	PUNCT
ijpds-7913	88	39	esicm	esicm	NOUN
ijpds-7913	88	40	)	)	PUNCT
ijpds-7913	88	41	and	and	CCONJ
ijpds-7913	88	42	the	the	DET
ijpds-7913	88	43	european	european	ADJ
ijpds-7913	88	44	society	society	NOUN
ijpds-7913	88	45	of	of	ADP
ijpds-7913	88	46	clinical	clinical	ADJ
ijpds-7913	88	47	microbiology	microbiology	NOUN
ijpds-7913	88	48	and	and	CCONJ
ijpds-7913	88	49	infectious	infectious	ADJ
ijpds-7913	88	50	diseases	disease	NOUN
ijpds-7913	88	51	(	(	PUNCT
ijpds-7913	88	52	escmid	escmid	NOUN
ijpds-7913	88	53	)	)	PUNCT
ijpds-7913	88	54	,	,	PUNCT
ijpds-7913	88	55	which	which	PRON
ijpds-7913	88	56	offer	offer	VERB
ijpds-7913	88	57	practical	practical	ADJ
ijpds-7913	88	58	frameworks	framework	NOUN
ijpds-7913	88	59	for	for	ADP
ijpds-7913	88	60	implementation	implementation	NOUN
ijpds-7913	88	61	[	[	X
ijpds-7913	88	62	20	20	NUM
ijpds-7913	88	63	]	]	PUNCT
ijpds-7913	88	64	.	.	PUNCT
ijpds-7913	89	1	b.	b.	PROPN
ijpds-7913	90	1	non	non	ADJ
ijpds-7913	90	2	-	-	ADJ
ijpds-7913	90	3	antimicrobial	antimicrobial	ADJ
ijpds-7913	90	4	applications	application	NOUN
ijpds-7913	90	5	in	in	ADP
ijpds-7913	90	6	addition	addition	NOUN
ijpds-7913	90	7	to	to	ADP
ijpds-7913	90	8	managing	manage	VERB
ijpds-7913	90	9	infectious	infectious	ADJ
ijpds-7913	90	10	diseases	disease	NOUN
ijpds-7913	90	11	,	,	PUNCT
ijpds-7913	90	12	therapeutic	therapeutic	ADJ
ijpds-7913	90	13	drug	drug	NOUN
ijpds-7913	90	14	monitoring	monitoring	NOUN
ijpds-7913	90	15	(	(	PUNCT
ijpds-7913	90	16	tdm	tdm	X
ijpds-7913	90	17	)	)	PUNCT
ijpds-7913	90	18	plays	play	VERB
ijpds-7913	90	19	a	a	DET
ijpds-7913	90	20	vital	vital	ADJ
ijpds-7913	90	21	role	role	NOUN
ijpds-7913	90	22	in	in	ADP
ijpds-7913	90	23	optimizing	optimize	VERB
ijpds-7913	90	24	treatment	treatment	NOUN
ijpds-7913	90	25	with	with	ADP
ijpds-7913	90	26	anticonvulsants	anticonvulsant	NOUN
ijpds-7913	90	27	,	,	PUNCT
ijpds-7913	90	28	immunosuppressants	immunosuppressant	NOUN
ijpds-7913	90	29	,	,	PUNCT
ijpds-7913	90	30	and	and	CCONJ
ijpds-7913	90	31	cardiovascular	cardiovascular	ADJ
ijpds-7913	90	32	medications	medication	NOUN
ijpds-7913	90	33	in	in	ADP
ijpds-7913	90	34	intensive	intensive	ADJ
ijpds-7913	90	35	care	care	NOUN
ijpds-7913	90	36	unit	unit	NOUN
ijpds-7913	90	37	(	(	PUNCT
ijpds-7913	90	38	icu	icu	PROPN
ijpds-7913	90	39	)	)	PUNCT
ijpds-7913	90	40	patients	patient	NOUN
ijpds-7913	90	41	.	.	PUNCT
ijpds-7913	91	1	agents	agent	NOUN
ijpds-7913	91	2	like	like	ADP
ijpds-7913	91	3	phenytoin	phenytoin	NOUN
ijpds-7913	91	4	and	and	CCONJ
ijpds-7913	91	5	valproic	valproic	ADJ
ijpds-7913	91	6	acid	acid	NOUN
ijpds-7913	91	7	demonstrate	demonstrate	NOUN
ijpds-7913	91	8	modified	modify	VERB
ijpds-7913	91	9	protein	protein	NOUN
ijpds-7913	91	10	binding	bind	VERB
ijpds-7913	91	11	in	in	ADP
ijpds-7913	91	12	hypo	hypo	ADJ
ijpds-7913	91	13	-	-	ADJ
ijpds-7913	91	14	albuminemic	albuminemic	ADJ
ijpds-7913	91	15	conditions	condition	NOUN
ijpds-7913	91	16	,	,	PUNCT
ijpds-7913	91	17	requiring	require	VERB
ijpds-7913	91	18	the	the	DET
ijpds-7913	91	19	assessment	assessment	NOUN
ijpds-7913	91	20	of	of	ADP
ijpds-7913	91	21	free	free	ADJ
ijpds-7913	91	22	drug	drug	NOUN
ijpds-7913	91	23	concentrations	concentration	NOUN
ijpds-7913	91	24	to	to	PART
ijpds-7913	91	25	inform	inform	VERB
ijpds-7913	91	26	dosage	dosage	NOUN
ijpds-7913	91	27	[	[	X
ijpds-7913	91	28	21	21	NUM
ijpds-7913	91	29	]	]	PUNCT
ijpds-7913	91	30	.	.	PUNCT
ijpds-7913	92	1	similarly	similarly	ADV
ijpds-7913	92	2	,	,	PUNCT
ijpds-7913	92	3	immunosuppressants	immunosuppressant	NOUN
ijpds-7913	92	4	like	like	ADP
ijpds-7913	92	5	tacrolimus	tacrolimus	NOUN
ijpds-7913	92	6	and	and	CCONJ
ijpds-7913	92	7	cyclosporine	cyclosporine	VERB
ijpds-7913	92	8	necessitate	necessitate	ADJ
ijpds-7913	92	9	monitoring	monitoring	NOUN
ijpds-7913	92	10	to	to	PART
ijpds-7913	92	11	equilibrate	equilibrate	VERB
ijpds-7913	92	12	rejection	rejection	NOUN
ijpds-7913	92	13	risk	risk	NOUN
ijpds-7913	92	14	with	with	ADP
ijpds-7913	92	15	toxicity	toxicity	NOUN
ijpds-7913	92	16	,	,	PUNCT
ijpds-7913	92	17	especially	especially	ADV
ijpds-7913	92	18	in	in	ADP
ijpds-7913	92	19	post	post	ADJ
ijpds-7913	92	20	-	-	ADJ
ijpds-7913	92	21	transplant	transplant	ADJ
ijpds-7913	92	22	patients	patient	NOUN
ijpds-7913	92	23	in	in	ADP
ijpds-7913	92	24	the	the	DET
ijpds-7913	92	25	icu	icu	PROPN
ijpds-7913	92	26	.	.	PUNCT
ijpds-7913	93	1	digoxin	digoxin	PROPN
ijpds-7913	93	2	,	,	PUNCT
ijpds-7913	93	3	a	a	DET
ijpds-7913	93	4	cardiac	cardiac	ADJ
ijpds-7913	93	5	glycoside	glycoside	NOUN
ijpds-7913	93	6	characterized	characterize	VERB
ijpds-7913	93	7	by	by	ADP
ijpds-7913	93	8	a	a	DET
ijpds-7913	93	9	narrow	narrow	ADJ
ijpds-7913	93	10	therapeutic	therapeutic	ADJ
ijpds-7913	93	11	index	index	NOUN
ijpds-7913	93	12	,	,	PUNCT
ijpds-7913	93	13	necessitates	necessitate	VERB
ijpds-7913	93	14	meticulous	meticulous	ADJ
ijpds-7913	93	15	monitoring	monitoring	NOUN
ijpds-7913	93	16	in	in	ADP
ijpds-7913	93	17	critically	critically	ADV
ijpds-7913	93	18	sick	sick	ADJ
ijpds-7913	93	19	patients	patient	NOUN
ijpds-7913	93	20	with	with	ADP
ijpds-7913	93	21	variable	variable	ADJ
ijpds-7913	93	22	renal	renal	ADJ
ijpds-7913	93	23	function	function	NOUN
ijpds-7913	93	24	.	.	PUNCT
ijpds-7913	94	1	these	these	DET
ijpds-7913	94	2	instances	instance	NOUN
ijpds-7913	94	3	demonstrate	demonstrate	VERB
ijpds-7913	94	4	the	the	DET
ijpds-7913	94	5	extensive	extensive	ADJ
ijpds-7913	94	6	applicability	applicability	NOUN
ijpds-7913	94	7	of	of	ADP
ijpds-7913	94	8	tdm	tdm	NOUN
ijpds-7913	94	9	beyond	beyond	ADP
ijpds-7913	94	10	antimicrobials	antimicrobial	NOUN
ijpds-7913	94	11	,	,	PUNCT
ijpds-7913	94	12	underscoring	underscore	VERB
ijpds-7913	94	13	its	its	PRON
ijpds-7913	94	14	significance	significance	NOUN
ijpds-7913	94	15	as	as	ADP
ijpds-7913	94	16	a	a	DET
ijpds-7913	94	17	fundamental	fundamental	ADJ
ijpds-7913	94	18	component	component	NOUN
ijpds-7913	94	19	of	of	ADP
ijpds-7913	94	20	personalized	personalized	ADJ
ijpds-7913	94	21	medication	medication	NOUN
ijpds-7913	94	22	in	in	ADP
ijpds-7913	94	23	critical	critical	ADJ
ijpds-7913	94	24	care	care	NOUN
ijpds-7913	95	1	[	[	X
ijpds-7913	95	2	22	22	NUM
ijpds-7913	95	3	]	]	PUNCT
ijpds-7913	95	4	.	.	PUNCT
ijpds-7913	96	1	ii	ii	PROPN
ijpds-7913	96	2	.	.	PUNCT
ijpds-7913	97	1	tdm	tdm	PROPN
ijpds-7913	97	2	in	in	ADP
ijpds-7913	97	3	transplant	transplant	NOUN
ijpds-7913	97	4	settings	setting	NOUN
ijpds-7913	97	5	tdm	tdm	NOUN
ijpds-7913	97	6	is	be	AUX
ijpds-7913	97	7	crucial	crucial	ADJ
ijpds-7913	97	8	in	in	ADP
ijpds-7913	97	9	managing	manage	VERB
ijpds-7913	97	10	transplant	transplant	NOUN
ijpds-7913	97	11	patients	patient	NOUN
ijpds-7913	97	12	,	,	PUNCT
ijpds-7913	97	13	since	since	SCONJ
ijpds-7913	97	14	it	it	PRON
ijpds-7913	97	15	is	be	AUX
ijpds-7913	97	16	vital	vital	ADJ
ijpds-7913	97	17	to	to	PART
ijpds-7913	97	18	maintain	maintain	VERB
ijpds-7913	97	19	a	a	DET
ijpds-7913	97	20	delicate	delicate	ADJ
ijpds-7913	97	21	equilibrium	equilibrium	NOUN
ijpds-7913	97	22	between	between	ADP
ijpds-7913	97	23	sufficient	sufficient	ADJ
ijpds-7913	97	24	immunosuppression	immunosuppression	NOUN
ijpds-7913	97	25	and	and	CCONJ
ijpds-7913	97	26	the	the	DET
ijpds-7913	97	27	prevention	prevention	NOUN
ijpds-7913	97	28	of	of	ADP
ijpds-7913	97	29	drug	drug	NOUN
ijpds-7913	97	30	-	-	PUNCT
ijpds-7913	97	31	related	relate	VERB
ijpds-7913	97	32	toxicity	toxicity	NOUN
ijpds-7913	97	33	.	.	PUNCT
ijpds-7913	98	1	post	post	ADJ
ijpds-7913	98	2	-	-	ADJ
ijpds-7913	98	3	transplant	transplant	ADJ
ijpds-7913	98	4	patients	patient	NOUN
ijpds-7913	98	5	need	need	VERB
ijpds-7913	98	6	prolonged	prolonged	ADJ
ijpds-7913	98	7	use	use	NOUN
ijpds-7913	98	8	of	of	ADP
ijpds-7913	98	9	immunosuppressive	immunosuppressive	ADJ
ijpds-7913	98	10	medications	medication	NOUN
ijpds-7913	98	11	,	,	PUNCT
ijpds-7913	98	12	including	include	VERB
ijpds-7913	98	13	calcineurin	calcineurin	ADJ
ijpds-7913	98	14	inhibitors	inhibitor	NOUN
ijpds-7913	98	15	(	(	PUNCT
ijpds-7913	98	16	cyclosporine	cyclosporine	NOUN
ijpds-7913	98	17	,	,	PUNCT
ijpds-7913	98	18	tacrolimus	tacrolimus	PROPN
ijpds-7913	98	19	)	)	PUNCT
ijpds-7913	98	20	,	,	PUNCT
ijpds-7913	98	21	mtor	mtor	NOUN
ijpds-7913	98	22	inhibitors	inhibitor	NOUN
ijpds-7913	98	23	(	(	PUNCT
ijpds-7913	98	24	sirolimus	sirolimus	NOUN
ijpds-7913	98	25	,	,	PUNCT
ijpds-7913	98	26	everolimus	everolimus	NOUN
ijpds-7913	98	27	)	)	PUNCT
ijpds-7913	98	28	,	,	PUNCT
ijpds-7913	98	29	mycophenolate	mycophenolate	PROPN
ijpds-7913	98	30	mofetil	mofetil	NOUN
ijpds-7913	98	31	,	,	PUNCT
ijpds-7913	98	32	and	and	CCONJ
ijpds-7913	98	33	corticosteroids	corticosteroid	NOUN
ijpds-7913	98	34	[	[	X
ijpds-7913	98	35	23	23	NUM
ijpds-7913	98	36	]	]	PUNCT
ijpds-7913	98	37	.	.	PUNCT
ijpds-7913	99	1	drugs	drug	NOUN
ijpds-7913	99	2	such	such	ADJ
ijpds-7913	99	3	as	as	ADP
ijpds-7913	99	4	tacrolimus	tacrolimus	NOUN
ijpds-7913	99	5	and	and	CCONJ
ijpds-7913	99	6	cyclosporine	cyclosporine	NOUN
ijpds-7913	99	7	exhibit	exhibit	VERB
ijpds-7913	99	8	a	a	DET
ijpds-7913	99	9	narrow	narrow	ADJ
ijpds-7913	99	10	therapeutic	therapeutic	ADJ
ijpds-7913	99	11	index	index	NOUN
ijpds-7913	99	12	,	,	PUNCT
ijpds-7913	99	13	considerable	considerable	ADJ
ijpds-7913	99	14	inter	inter	ADJ
ijpds-7913	99	15	-	-	ADJ
ijpds-7913	99	16	individual	individual	ADJ
ijpds-7913	99	17	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	99	18	variability	variability	NOUN
ijpds-7913	99	19	,	,	PUNCT
ijpds-7913	99	20	and	and	CCONJ
ijpds-7913	99	21	a	a	DET
ijpds-7913	99	22	substantial	substantial	ADJ
ijpds-7913	99	23	risk	risk	NOUN
ijpds-7913	99	24	for	for	ADP
ijpds-7913	99	25	drug	drug	NOUN
ijpds-7913	99	26	–	–	PUNCT
ijpds-7913	99	27	drug	drug	NOUN
ijpds-7913	99	28	and	and	CCONJ
ijpds-7913	99	29	drug	drug	NOUN
ijpds-7913	99	30	–	–	PUNCT
ijpds-7913	99	31	food	food	NOUN
ijpds-7913	99	32	interactions	interaction	NOUN
ijpds-7913	99	33	.	.	PUNCT
ijpds-7913	100	1	tdm	tdm	NOUN
ijpds-7913	100	2	is	be	AUX
ijpds-7913	100	3	essential	essential	ADJ
ijpds-7913	100	4	for	for	ADP
ijpds-7913	100	5	personalizing	personalize	VERB
ijpds-7913	100	6	treatment	treatment	NOUN
ijpds-7913	100	7	,	,	PUNCT
ijpds-7913	100	8	reducing	reduce	VERB
ijpds-7913	100	9	the	the	DET
ijpds-7913	100	10	likelihood	likelihood	NOUN
ijpds-7913	100	11	of	of	ADP
ijpds-7913	100	12	graft	graft	NOUN
ijpds-7913	100	13	rejection	rejection	NOUN
ijpds-7913	100	14	,	,	PUNCT
ijpds-7913	100	15	and	and	CCONJ
ijpds-7913	100	16	preventing	prevent	VERB
ijpds-7913	100	17	side	side	NOUN
ijpds-7913	100	18	effects	effect	NOUN
ijpds-7913	100	19	such	such	ADJ
ijpds-7913	100	20	as	as	ADP
ijpds-7913	100	21	nephrotoxicity	nephrotoxicity	NOUN
ijpds-7913	100	22	,	,	PUNCT
ijpds-7913	100	23	neurotoxicity	neurotoxicity	NOUN
ijpds-7913	100	24	,	,	PUNCT
ijpds-7913	100	25	and	and	CCONJ
ijpds-7913	100	26	infections	infection	NOUN
ijpds-7913	100	27	[	[	X
ijpds-7913	100	28	24	24	NUM
ijpds-7913	100	29	]	]	PUNCT
ijpds-7913	100	30	.	.	PUNCT
ijpds-7913	101	1	the	the	DET
ijpds-7913	101	2	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	101	3	of	of	ADP
ijpds-7913	101	4	immunosuppressants	immunosuppressant	NOUN
ijpds-7913	101	5	in	in	ADP
ijpds-7913	101	6	transplant	transplant	NOUN
ijpds-7913	101	7	recipients	recipient	NOUN
ijpds-7913	101	8	is	be	AUX
ijpds-7913	101	9	affected	affect	VERB
ijpds-7913	101	10	by	by	ADP
ijpds-7913	101	11	various	various	ADJ
ijpds-7913	101	12	patient	patient	NOUN
ijpds-7913	101	13	-	-	PUNCT
ijpds-7913	101	14	specific	specific	ADJ
ijpds-7913	101	15	and	and	CCONJ
ijpds-7913	101	16	procedural	procedural	ADJ
ijpds-7913	101	17	factors	factor	NOUN
ijpds-7913	101	18	,	,	PUNCT
ijpds-7913	101	19	including	include	VERB
ijpds-7913	101	20	age	age	NOUN
ijpds-7913	101	21	,	,	PUNCT
ijpds-7913	101	22	weight	weight	NOUN
ijpds-7913	101	23	,	,	PUNCT
ijpds-7913	101	24	genetic	genetic	ADJ
ijpds-7913	101	25	polymorphisms	polymorphism	NOUN
ijpds-7913	101	26	(	(	PUNCT
ijpds-7913	101	27	particularly	particularly	ADV
ijpds-7913	101	28	cyp3a5	cyp3a5	NOUN
ijpds-7913	101	29	variants	variant	NOUN
ijpds-7913	101	30	impacting	impact	VERB
ijpds-7913	101	31	agrawal	agrawal	PROPN
ijpds-7913	101	32	therapeutic	therapeutic	ADJ
ijpds-7913	101	33	drug	drug	NOUN
ijpds-7913	101	34	monitoring	monitoring	NOUN
ijpds-7913	101	35	in	in	ADP
ijpds-7913	101	36	critical	critical	ADJ
ijpds-7913	101	37	care	care	NOUN
ijpds-7913	101	38	and	and	CCONJ
ijpds-7913	101	39	transplants	transplant	NOUN
ijpds-7913	101	40	online	online	ADJ
ijpds-7913	101	41	first	first	PROPN
ijpds-7913	101	42	indian	indian	PROPN
ijpds-7913	101	43	j	j	PROPN
ijpds-7913	101	44	pharm	pharm	PROPN
ijpds-7913	101	45	drug	drug	PROPN
ijpds-7913	101	46	studies	study	NOUN
ijpds-7913	101	47	|	|	ADV
ijpds-7913	101	48	3	3	NUM
ijpds-7913	101	49	tacrolimus	tacrolimus	NOUN
ijpds-7913	101	50	metabolism	metabolism	NOUN
ijpds-7913	101	51	)	)	PUNCT
ijpds-7913	101	52	,	,	PUNCT
ijpds-7913	101	53	organ	organ	NOUN
ijpds-7913	101	54	function	function	NOUN
ijpds-7913	101	55	,	,	PUNCT
ijpds-7913	101	56	concomitant	concomitant	ADJ
ijpds-7913	101	57	medications	medication	NOUN
ijpds-7913	101	58	,	,	PUNCT
ijpds-7913	101	59	and	and	CCONJ
ijpds-7913	101	60	the	the	DET
ijpds-7913	101	61	type	type	NOUN
ijpds-7913	101	62	of	of	ADP
ijpds-7913	101	63	transplanted	transplanted	ADJ
ijpds-7913	101	64	organ	organ	NOUN
ijpds-7913	101	65	.	.	PUNCT
ijpds-7913	102	1	additionally	additionally	ADV
ijpds-7913	102	2	,	,	PUNCT
ijpds-7913	102	3	the	the	DET
ijpds-7913	102	4	post	post	ADJ
ijpds-7913	102	5	-	-	ADJ
ijpds-7913	102	6	operative	operative	ADJ
ijpds-7913	102	7	phase	phase	NOUN
ijpds-7913	102	8	frequently	frequently	ADV
ijpds-7913	102	9	exhibits	exhibit	VERB
ijpds-7913	102	10	erratic	erratic	ADJ
ijpds-7913	102	11	absorption	absorption	NOUN
ijpds-7913	102	12	and	and	CCONJ
ijpds-7913	102	13	metabolism	metabolism	NOUN
ijpds-7913	102	14	resulting	result	VERB
ijpds-7913	102	15	from	from	ADP
ijpds-7913	102	16	hemodynamic	hemodynamic	ADJ
ijpds-7913	102	17	instability	instability	NOUN
ijpds-7913	102	18	,	,	PUNCT
ijpds-7913	102	19	polypharmacy	polypharmacy	NOUN
ijpds-7913	102	20	,	,	PUNCT
ijpds-7913	102	21	and	and	CCONJ
ijpds-7913	102	22	fluctuating	fluctuate	VERB
ijpds-7913	102	23	gastrointestinal	gastrointestinal	ADJ
ijpds-7913	102	24	motility	motility	NOUN
ijpds-7913	102	25	.	.	PUNCT
ijpds-7913	103	1	thus	thus	ADV
ijpds-7913	103	2	,	,	PUNCT
ijpds-7913	103	3	conventional	conventional	ADJ
ijpds-7913	103	4	dosage	dosage	NOUN
ijpds-7913	103	5	protocols	protocol	NOUN
ijpds-7913	103	6	may	may	AUX
ijpds-7913	103	7	not	not	PART
ijpds-7913	103	8	consistently	consistently	ADV
ijpds-7913	103	9	forecast	forecast	VERB
ijpds-7913	103	10	drug	drug	NOUN
ijpds-7913	103	11	exposure	exposure	NOUN
ijpds-7913	103	12	,	,	PUNCT
ijpds-7913	103	13	rendering	render	VERB
ijpds-7913	103	14	personalized	personalize	VERB
ijpds-7913	103	15	tdm	tdm	NOUN
ijpds-7913	103	16	-	-	PUNCT
ijpds-7913	103	17	guided	guide	VERB
ijpds-7913	103	18	modifications	modification	NOUN
ijpds-7913	103	19	crucial	crucial	ADJ
ijpds-7913	103	20	for	for	ADP
ijpds-7913	103	21	best	good	ADJ
ijpds-7913	103	22	results	result	NOUN
ijpds-7913	103	23	[	[	X
ijpds-7913	103	24	25	25	NUM
ijpds-7913	103	25	]	]	PUNCT
ijpds-7913	103	26	.	.	PUNCT
ijpds-7913	104	1	in	in	ADP
ijpds-7913	104	2	clinical	clinical	ADJ
ijpds-7913	104	3	practice	practice	NOUN
ijpds-7913	104	4	,	,	PUNCT
ijpds-7913	104	5	trough	trough	NOUN
ijpds-7913	104	6	concentrations	concentration	NOUN
ijpds-7913	104	7	(	(	PUNCT
ijpds-7913	104	8	c0	c0	NOUN
ijpds-7913	104	9	)	)	PUNCT
ijpds-7913	104	10	are	be	AUX
ijpds-7913	104	11	the	the	DET
ijpds-7913	104	12	predominant	predominant	ADJ
ijpds-7913	104	13	monitoring	monitoring	NOUN
ijpds-7913	104	14	metric	metric	ADJ
ijpds-7913	104	15	for	for	ADP
ijpds-7913	104	16	calcineurin	calcineurin	ADJ
ijpds-7913	104	17	inhibitors	inhibitor	NOUN
ijpds-7913	104	18	and	and	CCONJ
ijpds-7913	104	19	mtor	mtor	NOUN
ijpds-7913	104	20	inhibitors	inhibitor	NOUN
ijpds-7913	104	21	in	in	ADP
ijpds-7913	104	22	clinical	clinical	ADJ
ijpds-7913	104	23	practice	practice	NOUN
ijpds-7913	104	24	,	,	PUNCT
ijpds-7913	104	25	owing	owe	VERB
ijpds-7913	104	26	to	to	ADP
ijpds-7913	104	27	their	their	PRON
ijpds-7913	104	28	simplicity	simplicity	NOUN
ijpds-7913	104	29	and	and	CCONJ
ijpds-7913	104	30	robust	robust	ADJ
ijpds-7913	104	31	connection	connection	NOUN
ijpds-7913	104	32	with	with	ADP
ijpds-7913	104	33	clinical	clinical	ADJ
ijpds-7913	104	34	success	success	NOUN
ijpds-7913	104	35	.	.	PUNCT
ijpds-7913	105	1	nevertheless	nevertheless	ADV
ijpds-7913	105	2	,	,	PUNCT
ijpds-7913	105	3	several	several	ADJ
ijpds-7913	105	4	studies	study	NOUN
ijpds-7913	105	5	indicate	indicate	VERB
ijpds-7913	105	6	that	that	SCONJ
ijpds-7913	105	7	monitoring	monitor	VERB
ijpds-7913	105	8	the	the	DET
ijpds-7913	105	9	area	area	NOUN
ijpds-7913	105	10	under	under	ADP
ijpds-7913	105	11	the	the	DET
ijpds-7913	105	12	concentration	concentration	NOUN
ijpds-7913	105	13	-	-	PUNCT
ijpds-7913	105	14	time	time	NOUN
ijpds-7913	105	15	curve	curve	NOUN
ijpds-7913	105	16	(	(	PUNCT
ijpds-7913	105	17	auc	auc	NOUN
ijpds-7913	105	18	)	)	PUNCT
ijpds-7913	105	19	may	may	AUX
ijpds-7913	105	20	offer	offer	VERB
ijpds-7913	105	21	a	a	DET
ijpds-7913	105	22	more	more	ADV
ijpds-7913	105	23	precise	precise	ADJ
ijpds-7913	105	24	assessment	assessment	NOUN
ijpds-7913	105	25	of	of	ADP
ijpds-7913	105	26	drug	drug	NOUN
ijpds-7913	105	27	exposure	exposure	NOUN
ijpds-7913	105	28	,	,	PUNCT
ijpds-7913	105	29	especially	especially	ADV
ijpds-7913	105	30	for	for	ADP
ijpds-7913	105	31	mycophenolate	mycophenolate	ADJ
ijpds-7913	105	32	mofetil	mofetil	NOUN
ijpds-7913	105	33	,	,	PUNCT
ijpds-7913	105	34	as	as	SCONJ
ijpds-7913	105	35	trough	trough	NOUN
ijpds-7913	105	36	levels	level	NOUN
ijpds-7913	105	37	may	may	AUX
ijpds-7913	105	38	not	not	PART
ijpds-7913	105	39	reliably	reliably	ADV
ijpds-7913	105	40	forecast	forecast	VERB
ijpds-7913	105	41	therapeutic	therapeutic	ADJ
ijpds-7913	105	42	effectiveness	effectiveness	NOUN
ijpds-7913	105	43	.	.	PUNCT
ijpds-7913	106	1	advancements	advancement	NOUN
ijpds-7913	106	2	in	in	ADP
ijpds-7913	106	3	bayesian	bayesian	NOUN
ijpds-7913	106	4	forecasting	forecasting	NOUN
ijpds-7913	106	5	and	and	CCONJ
ijpds-7913	106	6	population	population	NOUN
ijpds-7913	106	7	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	106	8	models	model	NOUN
ijpds-7913	106	9	have	have	AUX
ijpds-7913	106	10	facilitated	facilitate	VERB
ijpds-7913	106	11	limited	limited	ADJ
ijpds-7913	106	12	sampling	sampling	NOUN
ijpds-7913	106	13	tactics	tactic	NOUN
ijpds-7913	106	14	for	for	ADP
ijpds-7913	106	15	more	more	ADV
ijpds-7913	106	16	reliable	reliable	ADJ
ijpds-7913	106	17	auc	auc	NOUN
ijpds-7913	106	18	estimation	estimation	NOUN
ijpds-7913	106	19	,	,	PUNCT
ijpds-7913	106	20	therefore	therefore	ADV
ijpds-7913	106	21	alleviating	alleviate	VERB
ijpds-7913	106	22	patient	patient	ADJ
ijpds-7913	106	23	burden	burden	NOUN
ijpds-7913	106	24	and	and	CCONJ
ijpds-7913	106	25	enhancing	enhance	VERB
ijpds-7913	106	26	accuracy	accuracy	NOUN
ijpds-7913	106	27	[	[	X
ijpds-7913	106	28	26	26	NUM
ijpds-7913	106	29	]	]	PUNCT
ijpds-7913	106	30	.	.	PUNCT
ijpds-7913	107	1	the	the	DET
ijpds-7913	107	2	application	application	NOUN
ijpds-7913	107	3	of	of	ADP
ijpds-7913	107	4	tdm	tdm	NOUN
ijpds-7913	107	5	in	in	ADP
ijpds-7913	107	6	transplantation	transplantation	NOUN
ijpds-7913	107	7	transcends	transcend	VERB
ijpds-7913	107	8	effectiveness	effectiveness	NOUN
ijpds-7913	107	9	and	and	CCONJ
ijpds-7913	107	10	safety	safety	NOUN
ijpds-7913	107	11	,	,	PUNCT
ijpds-7913	107	12	incorporating	incorporate	VERB
ijpds-7913	107	13	long	long	ADJ
ijpds-7913	107	14	-	-	PUNCT
ijpds-7913	107	15	term	term	NOUN
ijpds-7913	107	16	graft	graft	NOUN
ijpds-7913	107	17	survival	survival	NOUN
ijpds-7913	107	18	.	.	PUNCT
ijpds-7913	108	1	evidence	evidence	NOUN
ijpds-7913	108	2	indicates	indicate	VERB
ijpds-7913	108	3	that	that	SCONJ
ijpds-7913	108	4	insufficient	insufficient	ADJ
ijpds-7913	108	5	immunosuppressant	immunosuppressant	ADJ
ijpds-7913	108	6	exposure	exposure	NOUN
ijpds-7913	108	7	is	be	AUX
ijpds-7913	108	8	a	a	DET
ijpds-7913	108	9	primary	primary	ADJ
ijpds-7913	108	10	factor	factor	NOUN
ijpds-7913	108	11	in	in	ADP
ijpds-7913	108	12	acute	acute	ADJ
ijpds-7913	108	13	rejection	rejection	NOUN
ijpds-7913	108	14	,	,	PUNCT
ijpds-7913	108	15	but	but	CCONJ
ijpds-7913	108	16	chronic	chronic	ADJ
ijpds-7913	108	17	overexposure	overexposure	NOUN
ijpds-7913	108	18	correlates	correlate	VERB
ijpds-7913	108	19	with	with	ADP
ijpds-7913	108	20	growing	grow	VERB
ijpds-7913	108	21	nephrotoxicity	nephrotoxicity	ADJ
ijpds-7913	108	22	and	and	CCONJ
ijpds-7913	108	23	metabolic	metabolic	NOUN
ijpds-7913	108	24	problems	problem	NOUN
ijpds-7913	108	25	.	.	PUNCT
ijpds-7913	109	1	incorporating	incorporate	VERB
ijpds-7913	109	2	tdm	tdm	NOUN
ijpds-7913	109	3	into	into	ADP
ijpds-7913	109	4	standard	standard	ADJ
ijpds-7913	109	5	post	post	ADJ
ijpds-7913	109	6	-	-	ADJ
ijpds-7913	109	7	transplant	transplant	ADJ
ijpds-7913	109	8	treatment	treatment	NOUN
ijpds-7913	109	9	enables	enable	VERB
ijpds-7913	109	10	doctors	doctor	NOUN
ijpds-7913	109	11	to	to	PART
ijpds-7913	109	12	proactively	proactively	ADV
ijpds-7913	109	13	manage	manage	VERB
ijpds-7913	109	14	inter	inter	ADJ
ijpds-7913	109	15	-	-	ADJ
ijpds-7913	109	16	individual	individual	ADJ
ijpds-7913	109	17	variability	variability	NOUN
ijpds-7913	109	18	and	and	CCONJ
ijpds-7913	109	19	customize	customize	VERB
ijpds-7913	109	20	regimens	regimen	NOUN
ijpds-7913	109	21	according	accord	VERB
ijpds-7913	109	22	to	to	ADP
ijpds-7913	109	23	patients	patient	NOUN
ijpds-7913	109	24	'	'	PART
ijpds-7913	109	25	changing	change	VERB
ijpds-7913	109	26	clinical	clinical	ADJ
ijpds-7913	109	27	conditions	condition	NOUN
ijpds-7913	109	28	.	.	PUNCT
ijpds-7913	110	1	moreover	moreover	ADV
ijpds-7913	110	2	,	,	PUNCT
ijpds-7913	110	3	the	the	DET
ijpds-7913	110	4	integration	integration	NOUN
ijpds-7913	110	5	of	of	ADP
ijpds-7913	110	6	pharmacogenomic	pharmacogenomic	ADJ
ijpds-7913	110	7	testing	testing	NOUN
ijpds-7913	110	8	with	with	ADP
ijpds-7913	110	9	therapeutic	therapeutic	ADJ
ijpds-7913	110	10	drug	drug	NOUN
ijpds-7913	110	11	monitoring	monitoring	NOUN
ijpds-7913	110	12	(	(	PUNCT
ijpds-7913	110	13	tdm	tdm	NOUN
ijpds-7913	110	14	)	)	PUNCT
ijpds-7913	110	15	presents	present	VERB
ijpds-7913	110	16	an	an	DET
ijpds-7913	110	17	opportunity	opportunity	NOUN
ijpds-7913	110	18	to	to	PART
ijpds-7913	110	19	enhance	enhance	VERB
ijpds-7913	110	20	dosing	dose	VERB
ijpds-7913	110	21	regimens	regimen	NOUN
ijpds-7913	110	22	,	,	PUNCT
ijpds-7913	110	23	advancing	advance	VERB
ijpds-7913	110	24	the	the	DET
ijpds-7913	110	25	concept	concept	NOUN
ijpds-7913	110	26	of	of	ADP
ijpds-7913	110	27	precision	precision	NOUN
ijpds-7913	110	28	medicine	medicine	NOUN
ijpds-7913	110	29	in	in	ADP
ijpds-7913	110	30	transplantation	transplantation	NOUN
ijpds-7913	110	31	[	[	X
ijpds-7913	110	32	27	27	NUM
ijpds-7913	110	33	]	]	PUNCT
ijpds-7913	110	34	.	.	PUNCT
ijpds-7913	111	1	overall	overall	ADJ
ijpds-7913	111	2	,	,	PUNCT
ijpds-7913	111	3	tdm	tdm	NOUN
ijpds-7913	111	4	in	in	ADP
ijpds-7913	111	5	the	the	DET
ijpds-7913	111	6	transplant	transplant	NOUN
ijpds-7913	111	7	context	context	NOUN
ijpds-7913	111	8	is	be	AUX
ijpds-7913	111	9	an	an	DET
ijpds-7913	111	10	emerging	emerge	VERB
ijpds-7913	111	11	yet	yet	CCONJ
ijpds-7913	111	12	essential	essential	ADJ
ijpds-7913	111	13	instrument	instrument	NOUN
ijpds-7913	111	14	.	.	PUNCT
ijpds-7913	112	1	current	current	ADJ
ijpds-7913	112	2	investigations	investigation	NOUN
ijpds-7913	112	3	into	into	ADP
ijpds-7913	112	4	innovative	innovative	ADJ
ijpds-7913	112	5	biomarkers	biomarker	NOUN
ijpds-7913	112	6	,	,	PUNCT
ijpds-7913	112	7	non	non	ADJ
ijpds-7913	112	8	-	-	ADJ
ijpds-7913	112	9	invasive	invasive	ADJ
ijpds-7913	112	10	monitoring	monitoring	NOUN
ijpds-7913	112	11	techniques	technique	NOUN
ijpds-7913	112	12	,	,	PUNCT
ijpds-7913	112	13	and	and	CCONJ
ijpds-7913	112	14	modelinformed	modelinforme	VERB
ijpds-7913	112	15	precision	precision	NOUN
ijpds-7913	112	16	dosage	dosage	NOUN
ijpds-7913	112	17	aim	aim	VERB
ijpds-7913	112	18	to	to	PART
ijpds-7913	112	19	improve	improve	VERB
ijpds-7913	112	20	its	its	PRON
ijpds-7913	112	21	efficacy	efficacy	NOUN
ijpds-7913	112	22	,	,	PUNCT
ijpds-7913	112	23	guaranteeing	guarantee	VERB
ijpds-7913	112	24	that	that	SCONJ
ijpds-7913	112	25	transplant	transplant	NOUN
ijpds-7913	112	26	recipients	recipient	NOUN
ijpds-7913	112	27	have	have	VERB
ijpds-7913	112	28	the	the	DET
ijpds-7913	112	29	most	most	ADV
ijpds-7913	112	30	effective	effective	ADJ
ijpds-7913	112	31	and	and	CCONJ
ijpds-7913	112	32	safest	safe	ADJ
ijpds-7913	112	33	immunosuppressive	immunosuppressive	ADJ
ijpds-7913	112	34	protocols	protocol	NOUN
ijpds-7913	112	35	for	for	ADP
ijpds-7913	112	36	sustained	sustained	ADJ
ijpds-7913	112	37	graft	graft	NOUN
ijpds-7913	112	38	function	function	NOUN
ijpds-7913	112	39	.	.	PUNCT
ijpds-7913	113	1	table	table	NOUN
ijpds-7913	113	2	1list	1list	NUM
ijpds-7913	113	3	of	of	ADP
ijpds-7913	113	4	drugs	drug	NOUN
ijpds-7913	113	5	requiring	require	VERB
ijpds-7913	113	6	tdm	tdm	NOUN
ijpds-7913	113	7	in	in	ADP
ijpds-7913	113	8	critical	critical	ADJ
ijpds-7913	113	9	care	care	NOUN
ijpds-7913	113	10	and	and	CCONJ
ijpds-7913	113	11	transplant	transplant	NOUN
ijpds-7913	113	12	settings	setting	NOUN
ijpds-7913	113	13	drug	drug	NOUN
ijpds-7913	113	14	/	/	SYM
ijpds-7913	113	15	class	class	NOUN
ijpds-7913	113	16	/	/	SYM
ijpds-7913	113	17	context	context	NOUN
ijpds-7913	113	18	tdm	tdm	NOUN
ijpds-7913	113	19	target	target	NOUN
ijpds-7913	113	20	/	/	SYM
ijpds-7913	113	21	metric	metric	ADJ
ijpds-7913	113	22	when	when	SCONJ
ijpds-7913	113	23	to	to	PART
ijpds-7913	113	24	sample	sample	VERB
ijpds-7913	113	25	clinical	clinical	ADJ
ijpds-7913	113	26	rationale	rationale	NOUN
ijpds-7913	113	27	&	&	CCONJ
ijpds-7913	113	28	icu	icu	PROPN
ijpds-7913	113	29	/	/	SYM
ijpds-7913	113	30	transplant	transplant	NOUN
ijpds-7913	113	31	notes	note	VERB
ijpds-7913	113	32	key	key	ADJ
ijpds-7913	113	33	references	reference	NOUN
ijpds-7913	113	34	vancomycin	vancomycin	PROPN
ijpds-7913	113	35	auc	auc	PROPN
ijpds-7913	113	36	/	/	SYM
ijpds-7913	113	37	mic	mic	NOUN
ijpds-7913	113	38	400–600	400–600	NUM
ijpds-7913	113	39	(	(	PUNCT
ijpds-7913	113	40	or	or	CCONJ
ijpds-7913	113	41	trough	trough	NOUN
ijpds-7913	113	42	15	15	NUM
ijpds-7913	113	43	–	–	SYM
ijpds-7913	113	44	20	20	NUM
ijpds-7913	113	45	mg	mg	NUM
ijpds-7913	113	46	/	/	SYM
ijpds-7913	113	47	l	l	NOUN
ijpds-7913	113	48	)	)	PUNCT
ijpds-7913	113	49	trough	trough	NOUN
ijpds-7913	113	50	before	before	ADP
ijpds-7913	113	51	4th	4th	ADJ
ijpds-7913	113	52	dose	dose	NOUN
ijpds-7913	113	53	or	or	CCONJ
ijpds-7913	113	54	steady	steady	ADJ
ijpds-7913	113	55	-	-	PUNCT
ijpds-7913	113	56	state	state	NOUN
ijpds-7913	113	57	aki	aki	NOUN
ijpds-7913	113	58	risk	risk	NOUN
ijpds-7913	113	59	↑	↑	PROPN
ijpds-7913	113	60	with	with	ADP
ijpds-7913	113	61	high	high	ADJ
ijpds-7913	113	62	troughs	trough	NOUN
ijpds-7913	113	63	;	;	PUNCT
ijpds-7913	113	64	auc	auc	NOUN
ijpds-7913	113	65	-	-	PUNCT
ijpds-7913	113	66	based	base	VERB
ijpds-7913	113	67	dosing	dosing	NOUN
ijpds-7913	113	68	preferred	prefer	VERB
ijpds-7913	113	69	over	over	ADP
ijpds-7913	113	70	trough	trough	NOUN
ijpds-7913	113	71	-	-	PUNCT
ijpds-7913	113	72	only	only	ADV
ijpds-7913	113	73	methods	method	NOUN
ijpds-7913	113	74	[	[	X
ijpds-7913	113	75	4	4	NUM
ijpds-7913	113	76	]	]	PUNCT
ijpds-7913	113	77	,	,	PUNCT
ijpds-7913	113	78	[	[	X
ijpds-7913	113	79	18	18	NUM
ijpds-7913	113	80	]	]	PUNCT
ijpds-7913	113	81	,	,	PUNCT
ijpds-7913	113	82	[	[	X
ijpds-7913	113	83	29	29	NUM
ijpds-7913	113	84	]	]	PUNCT
ijpds-7913	113	85	aminoglycosides	aminoglycoside	NOUN
ijpds-7913	113	86	(	(	PUNCT
ijpds-7913	113	87	amikacin	amikacin	PROPN
ijpds-7913	113	88	,	,	PUNCT
ijpds-7913	113	89	gentamicin	gentamicin	NOUN
ijpds-7913	113	90	)	)	PUNCT
ijpds-7913	113	91	peak	peak	NOUN
ijpds-7913	113	92	/	/	SYM
ijpds-7913	113	93	mic	mic	ADJ
ijpds-7913	113	94	≥8–10	≥8–10	NOUN
ijpds-7913	113	95	;	;	PUNCT
ijpds-7913	113	96	trough	trough	NOUN
ijpds-7913	113	97	<	<	X
ijpds-7913	113	98	1–2	1–2	NUM
ijpds-7913	113	99	mg	mg	PROPN
ijpds-7913	113	100	/	/	SYM
ijpds-7913	113	101	l	l	NOUN
ijpds-7913	113	102	peak	peak	NOUN
ijpds-7913	113	103	:	:	PUNCT
ijpds-7913	113	104	30	30	NUM
ijpds-7913	113	105	min	min	NOUN
ijpds-7913	113	106	postinfusion	postinfusion	NOUN
ijpds-7913	113	107	;	;	PUNCT
ijpds-7913	113	108	trough	trough	NOUN
ijpds-7913	113	109	:	:	PUNCT
ijpds-7913	113	110	before	before	SCONJ
ijpds-7913	113	111	dose	dose	NOUN
ijpds-7913	113	112	nephrotoxicity	nephrotoxicity	NOUN
ijpds-7913	113	113	,	,	PUNCT
ijpds-7913	113	114	ototoxicity	ototoxicity	NOUN
ijpds-7913	113	115	risk	risk	NOUN
ijpds-7913	113	116	;	;	PUNCT
ijpds-7913	113	117	altered	alter	VERB
ijpds-7913	113	118	pk	pk	NOUN
ijpds-7913	113	119	in	in	ADP
ijpds-7913	113	120	sepsis	sepsis	NOUN
ijpds-7913	113	121	,	,	PUNCT
ijpds-7913	113	122	ecmo	ecmo	NOUN
ijpds-7913	113	123	,	,	PUNCT
ijpds-7913	113	124	crrt	crrt	X
ijpds-7913	114	1	[	[	X
ijpds-7913	114	2	6	6	NUM
ijpds-7913	114	3	]	]	PUNCT
ijpds-7913	114	4	,	,	PUNCT
ijpds-7913	114	5	[	[	X
ijpds-7913	114	6	30	30	NUM
ijpds-7913	114	7	]	]	SYM
ijpds-7913	114	8	β	β	NOUN
ijpds-7913	114	9	-	-	PUNCT
ijpds-7913	114	10	lactams	lactam	NOUN
ijpds-7913	114	11	(	(	PUNCT
ijpds-7913	114	12	pip	pip	NOUN
ijpds-7913	114	13	-	-	PUNCT
ijpds-7913	114	14	tazo	tazo	NOUN
ijpds-7913	114	15	,	,	PUNCT
ijpds-7913	114	16	meropenem	meropenem	PROPN
ijpds-7913	114	17	,	,	PUNCT
ijpds-7913	114	18	etc	etc	X
ijpds-7913	114	19	.	.	X
ijpds-7913	114	20	)	)	PUNCT
ijpds-7913	114	21	time	time	NOUN
ijpds-7913	114	22	>	>	X
ijpds-7913	114	23	mic	mic	NOUN
ijpds-7913	114	24	:	:	PUNCT
ijpds-7913	114	25	100	100	NUM
ijpds-7913	114	26	%	%	NOUN
ijpds-7913	114	27	for	for	ADP
ijpds-7913	114	28	critically	critically	ADV
ijpds-7913	114	29	ill	ill	ADJ
ijpds-7913	114	30	random	random	ADJ
ijpds-7913	114	31	/	/	SYM
ijpds-7913	114	32	steadystate	steadystate	NOUN
ijpds-7913	114	33	sampling	sample	VERB
ijpds-7913	114	34	arc	arc	NOUN
ijpds-7913	114	35	,	,	PUNCT
ijpds-7913	114	36	crrt	crrt	NOUN
ijpds-7913	114	37	,	,	PUNCT
ijpds-7913	114	38	ecmo	ecmo	NOUN
ijpds-7913	114	39	→	→	PUNCT
ijpds-7913	114	40	altered	altered	ADJ
ijpds-7913	114	41	pk	pk	NOUN
ijpds-7913	114	42	;	;	PUNCT
ijpds-7913	114	43	continuous	continuous	ADJ
ijpds-7913	114	44	/	/	SYM
ijpds-7913	114	45	prolonged	prolonged	ADJ
ijpds-7913	114	46	infusion	infusion	NOUN
ijpds-7913	114	47	often	often	ADV
ijpds-7913	114	48	needed	need	VERB
ijpds-7913	114	49	[	[	PUNCT
ijpds-7913	114	50	16	16	NUM
ijpds-7913	114	51	]	]	PUNCT
ijpds-7913	114	52	,	,	PUNCT
ijpds-7913	114	53	[	[	X
ijpds-7913	114	54	17	17	NUM
ijpds-7913	114	55	]	]	PUNCT
ijpds-7913	114	56	,	,	PUNCT
ijpds-7913	114	57	[	[	X
ijpds-7913	114	58	31	31	NUM
ijpds-7913	114	59	–	–	SYM
ijpds-7913	114	60	33	33	NUM
ijpds-7913	114	61	]	]	PUNCT
ijpds-7913	114	62	linezolid	linezolid	NOUN
ijpds-7913	114	63	trough	trough	NOUN
ijpds-7913	114	64	2–8	2–8	NUM
ijpds-7913	114	65	mg	mg	PROPN
ijpds-7913	114	66	/	/	SYM
ijpds-7913	114	67	l	l	NOUN
ijpds-7913	114	68	pre	pre	ADJ
ijpds-7913	114	69	-	-	ADJ
ijpds-7913	114	70	dose	dose	ADJ
ijpds-7913	114	71	trough	trough	NOUN
ijpds-7913	114	72	toxicity	toxicity	NOUN
ijpds-7913	114	73	risk	risk	NOUN
ijpds-7913	114	74	if	if	SCONJ
ijpds-7913	114	75	>	>	X
ijpds-7913	114	76	10	10	NUM
ijpds-7913	114	77	mg	mg	NUM
ijpds-7913	114	78	/	/	SYM
ijpds-7913	114	79	l	l	NOUN
ijpds-7913	114	80	;	;	PUNCT
ijpds-7913	114	81	thrombocytopenia	thrombocytopenia	PROPN
ijpds-7913	114	82	,	,	PUNCT
ijpds-7913	114	83	lactic	lactic	ADJ
ijpds-7913	114	84	acidosis	acidosis	NOUN
ijpds-7913	114	85	concerns	concern	NOUN
ijpds-7913	114	86	[	[	PUNCT
ijpds-7913	114	87	34	34	NUM
ijpds-7913	114	88	]	]	PUNCT
ijpds-7913	114	89	azoles	azole	NOUN
ijpds-7913	114	90	(	(	PUNCT
ijpds-7913	114	91	voriconazole	voriconazole	NOUN
ijpds-7913	114	92	,	,	PUNCT
ijpds-7913	114	93	posaconazole	posaconazole	NOUN
ijpds-7913	114	94	)	)	PUNCT
ijpds-7913	114	95	voriconazole	voriconazole	NOUN
ijpds-7913	114	96	:	:	PUNCT
ijpds-7913	114	97	2–5.5	2–5.5	NUM
ijpds-7913	114	98	mg	mg	NUM
ijpds-7913	114	99	/	/	SYM
ijpds-7913	114	100	l	l	NOUN
ijpds-7913	114	101	;	;	PUNCT
ijpds-7913	114	102	posaconazole	posaconazole	NOUN
ijpds-7913	114	103	:	:	PUNCT
ijpds-7913	114	104	>	>	PUNCT
ijpds-7913	114	105	1	1	NUM
ijpds-7913	114	106	mg	mg	NUM
ijpds-7913	114	107	/	/	SYM
ijpds-7913	114	108	l	l	NOUN
ijpds-7913	114	109	trough	trough	NOUN
ijpds-7913	114	110	after	after	ADP
ijpds-7913	114	111	≥5	≥5	NUM
ijpds-7913	114	112	days	day	NOUN
ijpds-7913	114	113	of	of	ADP
ijpds-7913	114	114	therapy	therapy	NOUN
ijpds-7913	114	115	cyp2c19	cyp2c19	NOUN
ijpds-7913	114	116	polymorphism	polymorphism	NOUN
ijpds-7913	114	117	affects	affect	VERB
ijpds-7913	114	118	voriconazole	voriconazole	NOUN
ijpds-7913	114	119	levels	level	NOUN
ijpds-7913	114	120	;	;	PUNCT
ijpds-7913	114	121	toxicity	toxicity	NOUN
ijpds-7913	114	122	>	>	SYM
ijpds-7913	114	123	5.5	5.5	NUM
ijpds-7913	114	124	mg	mg	NUM
ijpds-7913	114	125	/	/	SYM
ijpds-7913	114	126	l	l	NOUN
ijpds-7913	114	127	(	(	PUNCT
ijpds-7913	114	128	neurotoxicity	neurotoxicity	NOUN
ijpds-7913	114	129	)	)	PUNCT
ijpds-7913	115	1	[	[	X
ijpds-7913	115	2	19	19	NUM
ijpds-7913	115	3	]	]	PUNCT
ijpds-7913	115	4	,	,	PUNCT
ijpds-7913	115	5	[	[	X
ijpds-7913	115	6	35	35	NUM
ijpds-7913	115	7	]	]	PUNCT
ijpds-7913	115	8	,	,	PUNCT
ijpds-7913	115	9	[	[	X
ijpds-7913	115	10	36	36	NUM
ijpds-7913	115	11	]	]	PUNCT
ijpds-7913	115	12	flucytosine	flucytosine	NOUN
ijpds-7913	115	13	peak	peak	NOUN
ijpds-7913	115	14	30–80	30–80	NUM
ijpds-7913	115	15	µg	µg	NOUN
ijpds-7913	115	16	/	/	SYM
ijpds-7913	115	17	ml	ml	NOUN
ijpds-7913	115	18	;	;	PUNCT
ijpds-7913	115	19	trough	trough	NOUN
ijpds-7913	115	20	<	<	X
ijpds-7913	115	21	25	25	NUM
ijpds-7913	115	22	–	–	SYM
ijpds-7913	115	23	50	50	NUM
ijpds-7913	115	24	µg	µg	NOUN
ijpds-7913	115	25	/	/	SYM
ijpds-7913	115	26	ml	ml	NOUN
ijpds-7913	115	27	peak	peak	NOUN
ijpds-7913	115	28	2h	2h	NUM
ijpds-7913	115	29	post	post	NOUN
ijpds-7913	115	30	-	-	ADJ
ijpds-7913	115	31	dose	dose	ADJ
ijpds-7913	115	32	;	;	PUNCT
ijpds-7913	115	33	trough	trough	NOUN
ijpds-7913	115	34	before	before	ADP
ijpds-7913	115	35	next	next	ADJ
ijpds-7913	115	36	dose	dose	NOUN
ijpds-7913	115	37	myelotoxicity	myelotoxicity	NOUN
ijpds-7913	115	38	risk	risk	NOUN
ijpds-7913	115	39	if	if	SCONJ
ijpds-7913	115	40	>	>	X
ijpds-7913	115	41	100	100	NUM
ijpds-7913	115	42	µg	µg	NOUN
ijpds-7913	115	43	/	/	SYM
ijpds-7913	115	44	ml	ml	NOUN
ijpds-7913	115	45	;	;	PUNCT
ijpds-7913	115	46	dose	dose	NOUN
ijpds-7913	115	47	adjustment	adjustment	NOUN
ijpds-7913	115	48	in	in	ADP
ijpds-7913	115	49	renal	renal	ADJ
ijpds-7913	115	50	failure	failure	NOUN
ijpds-7913	115	51	[	[	X
ijpds-7913	115	52	19	19	NUM
ijpds-7913	115	53	]	]	PUNCT
ijpds-7913	115	54	,	,	PUNCT
ijpds-7913	115	55	[	[	X
ijpds-7913	115	56	37	37	NUM
ijpds-7913	115	57	]	]	X
ijpds-7913	115	58	tacrolimus	tacrolimus	NOUN
ijpds-7913	115	59	(	(	PUNCT
ijpds-7913	115	60	calcineurin	calcineurin	NOUN
ijpds-7913	115	61	inhibitor	inhibitor	NOUN
ijpds-7913	115	62	)	)	PUNCT
ijpds-7913	115	63	trough	trough	NOUN
ijpds-7913	115	64	5–15	5–15	PROPN
ijpds-7913	115	65	ng	ng	PROPN
ijpds-7913	115	66	/	/	SYM
ijpds-7913	115	67	ml	ml	PROPN
ijpds-7913	115	68	(	(	PUNCT
ijpds-7913	115	69	organ	organ	NOUN
ijpds-7913	115	70	/	/	SYM
ijpds-7913	115	71	timespecific	timespecific	NOUN
ijpds-7913	115	72	)	)	PUNCT
ijpds-7913	115	73	12	12	NUM
ijpds-7913	115	74	-	-	PUNCT
ijpds-7913	115	75	h	h	NOUN
ijpds-7913	115	76	trough	trough	NOUN
ijpds-7913	115	77	(	(	PUNCT
ijpds-7913	115	78	c0	c0	NOUN
ijpds-7913	115	79	)	)	PUNCT
ijpds-7913	115	80	narrow	narrow	ADJ
ijpds-7913	115	81	ti	ti	NOUN
ijpds-7913	115	82	;	;	PUNCT
ijpds-7913	115	83	cyp3a5	cyp3a5	NOUN
ijpds-7913	115	84	polymorphism	polymorphism	NOUN
ijpds-7913	115	85	affects	affect	VERB
ijpds-7913	115	86	metabolism	metabolism	NOUN
ijpds-7913	115	87	;	;	PUNCT
ijpds-7913	115	88	toxicity	toxicity	NOUN
ijpds-7913	115	89	:	:	PUNCT
ijpds-7913	115	90	nephro	nephro	NOUN
ijpds-7913	115	91	/	/	SYM
ijpds-7913	115	92	neurotoxicity	neurotoxicity	NOUN
ijpds-7913	115	93	,	,	PUNCT
ijpds-7913	115	94	infections	infection	NOUN
ijpds-7913	115	95	[	[	X
ijpds-7913	115	96	22–27	22–27	NUM
ijpds-7913	115	97	]	]	PUNCT
ijpds-7913	115	98	,	,	PUNCT
ijpds-7913	115	99	[	[	X
ijpds-7913	115	100	38	38	NUM
ijpds-7913	115	101	]	]	PUNCT
ijpds-7913	115	102	cyclosporine	cyclosporine	NOUN
ijpds-7913	115	103	(	(	PUNCT
ijpds-7913	115	104	calcineurin	calcineurin	ADJ
ijpds-7913	115	105	inhibitor	inhibitor	NOUN
ijpds-7913	115	106	)	)	PUNCT
ijpds-7913	115	107	trough	trough	NOUN
ijpds-7913	115	108	100–400	100–400	NUM
ijpds-7913	115	109	ng	ng	PROPN
ijpds-7913	115	110	/	/	SYM
ijpds-7913	115	111	ml	ml	PROPN
ijpds-7913	115	112	;	;	PUNCT
ijpds-7913	115	113	some	some	DET
ijpds-7913	115	114	centers	center	NOUN
ijpds-7913	115	115	use	use	VERB
ijpds-7913	115	116	c2	c2	PROPN
ijpds-7913	115	117	sampling	sample	VERB
ijpds-7913	115	118	trough	trough	NOUN
ijpds-7913	115	119	(	(	PUNCT
ijpds-7913	115	120	c0	c0	NOUN
ijpds-7913	115	121	)	)	PUNCT
ijpds-7913	115	122	or	or	CCONJ
ijpds-7913	115	123	2	2	NUM
ijpds-7913	115	124	-	-	PUNCT
ijpds-7913	115	125	h	h	PRON
ijpds-7913	115	126	post	post	NOUN
ijpds-7913	115	127	-	-	ADJ
ijpds-7913	115	128	dose	dose	ADJ
ijpds-7913	115	129	(	(	PUNCT
ijpds-7913	115	130	c2	c2	PROPN
ijpds-7913	115	131	)	)	PUNCT
ijpds-7913	115	132	auc	auc	NOUN
ijpds-7913	115	133	-	-	PUNCT
ijpds-7913	115	134	based	base	VERB
ijpds-7913	115	135	dosing	dosing	NOUN
ijpds-7913	115	136	may	may	AUX
ijpds-7913	115	137	improve	improve	VERB
ijpds-7913	115	138	outcomes	outcome	NOUN
ijpds-7913	115	139	;	;	PUNCT
ijpds-7913	115	140	multiple	multiple	ADJ
ijpds-7913	115	141	interactions	interaction	NOUN
ijpds-7913	115	142	with	with	ADP
ijpds-7913	115	143	drugs	drug	NOUN
ijpds-7913	115	144	/	/	SYM
ijpds-7913	115	145	food	food	NOUN
ijpds-7913	115	146	[	[	X
ijpds-7913	115	147	39	39	NUM
ijpds-7913	115	148	]	]	PUNCT
ijpds-7913	115	149	,	,	PUNCT
ijpds-7913	115	150	[	[	X
ijpds-7913	115	151	43	43	NUM
ijpds-7913	115	152	]	]	X
ijpds-7913	115	153	sirolimus	sirolimus	NOUN
ijpds-7913	115	154	(	(	PUNCT
ijpds-7913	115	155	mtor	mtor	NOUN
ijpds-7913	115	156	inhibitor	inhibitor	NOUN
ijpds-7913	115	157	)	)	PUNCT
ijpds-7913	115	158	trough	trough	NOUN
ijpds-7913	115	159	5–15	5–15	PROPN
ijpds-7913	115	160	ng	ng	PROPN
ijpds-7913	115	161	/	/	SYM
ijpds-7913	115	162	ml	ml	PROPN
ijpds-7913	115	163	24	24	NUM
ijpds-7913	115	164	-	-	PUNCT
ijpds-7913	115	165	h	h	NOUN
ijpds-7913	115	166	trough	trough	NOUN
ijpds-7913	115	167	long	long	ADJ
ijpds-7913	115	168	half	half	ADJ
ijpds-7913	115	169	-	-	PUNCT
ijpds-7913	115	170	life	life	NOUN
ijpds-7913	115	171	;	;	PUNCT
ijpds-7913	115	172	cytopenias	cytopenia	NOUN
ijpds-7913	115	173	,	,	PUNCT
ijpds-7913	115	174	hyperlipidemia	hyperlipidemia	NOUN
ijpds-7913	115	175	;	;	PUNCT
ijpds-7913	115	176	erratic	erratic	ADJ
ijpds-7913	115	177	absorption	absorption	NOUN
ijpds-7913	115	178	post	post	NOUN
ijpds-7913	115	179	-	-	ADJ
ijpds-7913	115	180	transplant	transplant	ADJ
ijpds-7913	115	181	[	[	X
ijpds-7913	115	182	40	40	NUM
ijpds-7913	115	183	]	]	X
ijpds-7913	115	184	everolimus	everolimus	NOUN
ijpds-7913	115	185	(	(	PUNCT
ijpds-7913	115	186	mtor	mtor	NOUN
ijpds-7913	115	187	inhibitor	inhibitor	NOUN
ijpds-7913	115	188	)	)	PUNCT
ijpds-7913	115	189	trough	trough	NOUN
ijpds-7913	115	190	3–8	3–8	NUM
ijpds-7913	115	191	ng	ng	NOUN
ijpds-7913	115	192	/	/	SYM
ijpds-7913	115	193	ml	ml	PROPN
ijpds-7913	115	194	24	24	NUM
ijpds-7913	115	195	-	-	PUNCT
ijpds-7913	115	196	h	h	NOUN
ijpds-7913	115	197	trough	trough	NOUN
ijpds-7913	115	198	renal	renal	ADJ
ijpds-7913	115	199	-	-	PUNCT
ijpds-7913	115	200	sparing	spare	VERB
ijpds-7913	115	201	protocols	protocol	NOUN
ijpds-7913	115	202	;	;	PUNCT
ijpds-7913	115	203	post	post	ADJ
ijpds-7913	115	204	-	-	ADJ
ijpds-7913	115	205	op	op	ADJ
ijpds-7913	115	206	pk	pk	NOUN
ijpds-7913	115	207	variability	variability	NOUN
ijpds-7913	116	1	[	[	X
ijpds-7913	116	2	41	41	NUM
ijpds-7913	116	3	]	]	X
ijpds-7913	116	4	mycophenolate	mycophenolate	PROPN
ijpds-7913	116	5	mofetil	mofetil	PROPN
ijpds-7913	116	6	(	(	PUNCT
ijpds-7913	116	7	mmf	mmf	NOUN
ijpds-7913	116	8	)	)	PUNCT
ijpds-7913	116	9	auc0–12	auc0–12	PROPN
ijpds-7913	116	10	>	>	PUNCT
ijpds-7913	116	11	30–60	30–60	NUM
ijpds-7913	116	12	mg·h	mg·h	PROPN
ijpds-7913	116	13	/	/	SYM
ijpds-7913	116	14	l	l	NOUN
ijpds-7913	116	15	bayesian	bayesian	NOUN
ijpds-7913	116	16	auc	auc	NOUN
ijpds-7913	116	17	or	or	CCONJ
ijpds-7913	116	18	limited	limited	ADJ
ijpds-7913	116	19	sampling	sampling	NOUN
ijpds-7913	116	20	trough	trough	NOUN
ijpds-7913	116	21	not	not	PART
ijpds-7913	116	22	reliable	reliable	ADJ
ijpds-7913	116	23	for	for	ADP
ijpds-7913	116	24	efficacy	efficacy	NOUN
ijpds-7913	116	25	;	;	PUNCT
ijpds-7913	116	26	aucbased	aucbase	VERB
ijpds-7913	116	27	monitoring	monitoring	NOUN
ijpds-7913	116	28	increasingly	increasingly	ADV
ijpds-7913	116	29	used	use	VERB
ijpds-7913	116	30	[	[	PUNCT
ijpds-7913	116	31	42	42	NUM
ijpds-7913	116	32	]	]	PUNCT
ijpds-7913	116	33	corticosteroids	corticosteroid	NOUN
ijpds-7913	116	34	no	no	DET
ijpds-7913	116	35	standard	standard	ADJ
ijpds-7913	116	36	tdm	tdm	NOUN
ijpds-7913	116	37	clinical	clinical	NOUN
ijpds-7913	116	38	+	+	CCONJ
ijpds-7913	116	39	biomarker	biomarker	NOUN
ijpds-7913	116	40	endpoints	endpoint	NOUN
ijpds-7913	116	41	only	only	ADV
ijpds-7913	116	42	pk	pk	NOUN
ijpds-7913	116	43	variability	variability	NOUN
ijpds-7913	116	44	post	post	NOUN
ijpds-7913	116	45	-	-	NOUN
ijpds-7913	116	46	op	op	NOUN
ijpds-7913	116	47	;	;	PUNCT
ijpds-7913	116	48	risk	risk	NOUN
ijpds-7913	116	49	of	of	ADP
ijpds-7913	116	50	metabolic	metabolic	NOUN
ijpds-7913	116	51	&	&	CCONJ
ijpds-7913	116	52	infectious	infectious	ADJ
ijpds-7913	116	53	complications	complication	NOUN
ijpds-7913	116	54	[	[	X
ijpds-7913	116	55	7	7	NUM
ijpds-7913	116	56	]	]	PUNCT
ijpds-7913	116	57	,	,	PUNCT
ijpds-7913	116	58	[	[	X
ijpds-7913	116	59	23–27	23–27	NOUN
ijpds-7913	116	60	]	]	SYM
ijpds-7913	116	61	precision	precision	NOUN
ijpds-7913	116	62	medicine	medicine	NOUN
ijpds-7913	116	63	&	&	CCONJ
ijpds-7913	116	64	tdm	tdm	PROPN
ijpds-7913	116	65	advances	advance	NOUN
ijpds-7913	116	66	bayesian	bayesian	NOUN
ijpds-7913	116	67	modeling	modeling	NOUN
ijpds-7913	116	68	,	,	PUNCT
ijpds-7913	116	69	pharmacogenomics	pharmacogenomic	NOUN
ijpds-7913	116	70	(	(	PUNCT
ijpds-7913	116	71	cyp3a5	cyp3a5	NOUN
ijpds-7913	116	72	)	)	PUNCT
ijpds-7913	116	73	limited	limited	ADJ
ijpds-7913	116	74	sampling	sampling	NOUN
ijpds-7913	116	75	+	+	CCONJ
ijpds-7913	116	76	model	model	NOUN
ijpds-7913	116	77	-	-	PUNCT
ijpds-7913	116	78	informed	inform	VERB
ijpds-7913	116	79	dosing	dosing	NOUN
ijpds-7913	116	80	enables	enable	NOUN
ijpds-7913	116	81	individualized	individualized	ADJ
ijpds-7913	116	82	regimens	regimen	NOUN
ijpds-7913	116	83	,	,	PUNCT
ijpds-7913	116	84	reduced	reduce	VERB
ijpds-7913	116	85	toxicity	toxicity	NOUN
ijpds-7913	116	86	,	,	PUNCT
ijpds-7913	116	87	improved	improve	VERB
ijpds-7913	116	88	graft	graft	NOUN
ijpds-7913	116	89	survival	survival	NOUN
ijpds-7913	117	1	[	[	X
ijpds-7913	117	2	4	4	NUM
ijpds-7913	117	3	]	]	PUNCT
ijpds-7913	117	4	,	,	PUNCT
ijpds-7913	117	5	[	[	X
ijpds-7913	117	6	10	10	NUM
ijpds-7913	117	7	]	]	PUNCT
ijpds-7913	117	8	,	,	PUNCT
ijpds-7913	117	9	[	[	X
ijpds-7913	117	10	26	26	NUM
ijpds-7913	117	11	–	–	SYM
ijpds-7913	117	12	27	27	NUM
ijpds-7913	117	13	]	]	PUNCT
ijpds-7913	117	14	agrawal	agrawal	PROPN
ijpds-7913	117	15	therapeutic	therapeutic	ADJ
ijpds-7913	117	16	drug	drug	NOUN
ijpds-7913	117	17	monitoring	monitoring	NOUN
ijpds-7913	117	18	in	in	ADP
ijpds-7913	117	19	critical	critical	ADJ
ijpds-7913	117	20	care	care	NOUN
ijpds-7913	117	21	and	and	CCONJ
ijpds-7913	117	22	transplants	transplant	NOUN
ijpds-7913	117	23	online	online	ADJ
ijpds-7913	117	24	first	first	PROPN
ijpds-7913	117	25	indian	indian	PROPN
ijpds-7913	117	26	j	j	PROPN
ijpds-7913	117	27	pharm	pharm	PROPN
ijpds-7913	117	28	drug	drug	PROPN
ijpds-7913	117	29	studies	study	NOUN
ijpds-7913	117	30	|	|	ADV
ijpds-7913	117	31	4	4	NUM
ijpds-7913	117	32	challenges	challenge	NOUN
ijpds-7913	117	33	and	and	CCONJ
ijpds-7913	117	34	future	future	ADJ
ijpds-7913	117	35	direction	direction	NOUN
ijpds-7913	117	36	notwithstanding	notwithstanding	ADP
ijpds-7913	117	37	its	its	PRON
ijpds-7913	117	38	acknowledged	acknowledge	VERB
ijpds-7913	117	39	advantages	advantage	NOUN
ijpds-7913	117	40	,	,	PUNCT
ijpds-7913	117	41	therapeutic	therapeutic	ADJ
ijpds-7913	117	42	drug	drug	NOUN
ijpds-7913	117	43	monitoring	monitoring	NOUN
ijpds-7913	117	44	in	in	ADP
ijpds-7913	117	45	the	the	DET
ijpds-7913	117	46	intensive	intensive	ADJ
ijpds-7913	117	47	care	care	NOUN
ijpds-7913	117	48	unit	unit	NOUN
ijpds-7913	117	49	encounters	encounter	VERB
ijpds-7913	117	50	several	several	ADJ
ijpds-7913	117	51	obstacles	obstacle	NOUN
ijpds-7913	117	52	.	.	PUNCT
ijpds-7913	118	1	the	the	DET
ijpds-7913	118	2	restricted	restricted	ADJ
ijpds-7913	118	3	availability	availability	NOUN
ijpds-7913	118	4	of	of	ADP
ijpds-7913	118	5	tests	test	NOUN
ijpds-7913	118	6	for	for	ADP
ijpds-7913	118	7	novel	novel	ADJ
ijpds-7913	118	8	pharmaceuticals	pharmaceutical	NOUN
ijpds-7913	118	9	,	,	PUNCT
ijpds-7913	118	10	inconsistencies	inconsistency	NOUN
ijpds-7913	118	11	in	in	ADP
ijpds-7913	118	12	laboratory	laboratory	NOUN
ijpds-7913	118	13	turnaround	turnaround	PROPN
ijpds-7913	118	14	times	time	NOUN
ijpds-7913	118	15	,	,	PUNCT
ijpds-7913	118	16	and	and	CCONJ
ijpds-7913	118	17	the	the	DET
ijpds-7913	118	18	absence	absence	NOUN
ijpds-7913	118	19	of	of	ADP
ijpds-7913	118	20	standardized	standardized	ADJ
ijpds-7913	118	21	dosage	dosage	NOUN
ijpds-7913	118	22	algorithms	algorithm	NOUN
ijpds-7913	118	23	impede	impede	VERB
ijpds-7913	118	24	its	its	PRON
ijpds-7913	118	25	regular	regular	ADJ
ijpds-7913	118	26	implementation	implementation	NOUN
ijpds-7913	118	27	.	.	PUNCT
ijpds-7913	119	1	furthermore	furthermore	ADV
ijpds-7913	119	2	,	,	PUNCT
ijpds-7913	119	3	the	the	DET
ijpds-7913	119	4	interpretation	interpretation	NOUN
ijpds-7913	119	5	of	of	ADP
ijpds-7913	119	6	therapeutic	therapeutic	ADJ
ijpds-7913	119	7	drug	drug	NOUN
ijpds-7913	119	8	monitoring	monitoring	NOUN
ijpds-7913	119	9	necessitates	necessitate	VERB
ijpds-7913	119	10	the	the	DET
ijpds-7913	119	11	amalgamation	amalgamation	NOUN
ijpds-7913	119	12	of	of	ADP
ijpds-7913	119	13	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	119	14	and	and	CCONJ
ijpds-7913	119	15	pharmacodynamic	pharmacodynamic	ADJ
ijpds-7913	119	16	principles	principle	NOUN
ijpds-7913	119	17	with	with	ADP
ijpds-7913	119	18	the	the	DET
ijpds-7913	119	19	evolving	evolve	VERB
ijpds-7913	119	20	clinical	clinical	ADJ
ijpds-7913	119	21	situation	situation	NOUN
ijpds-7913	119	22	,	,	PUNCT
ijpds-7913	119	23	rather	rather	ADV
ijpds-7913	119	24	than	than	ADP
ijpds-7913	119	25	dependence	dependence	NOUN
ijpds-7913	119	26	on	on	ADP
ijpds-7913	119	27	fixed	fix	VERB
ijpds-7913	119	28	reference	reference	NOUN
ijpds-7913	119	29	ranges	range	NOUN
ijpds-7913	119	30	.	.	PUNCT
ijpds-7913	120	1	improvements	improvement	NOUN
ijpds-7913	120	2	in	in	ADP
ijpds-7913	120	3	bedside	bedside	NOUN
ijpds-7913	120	4	tests	test	NOUN
ijpds-7913	120	5	,	,	PUNCT
ijpds-7913	120	6	population	population	NOUN
ijpds-7913	120	7	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	120	8	modelling	modelling	NOUN
ijpds-7913	120	9	,	,	PUNCT
ijpds-7913	120	10	and	and	CCONJ
ijpds-7913	120	11	bayesian	bayesian	NOUN
ijpds-7913	120	12	dosing	dose	VERB
ijpds-7913	120	13	software	software	NOUN
ijpds-7913	120	14	are	be	AUX
ijpds-7913	120	15	expected	expect	VERB
ijpds-7913	120	16	to	to	PART
ijpds-7913	120	17	increase	increase	VERB
ijpds-7913	120	18	the	the	DET
ijpds-7913	120	19	accessibility	accessibility	NOUN
ijpds-7913	120	20	and	and	CCONJ
ijpds-7913	120	21	clinical	clinical	ADJ
ijpds-7913	120	22	applicability	applicability	NOUN
ijpds-7913	120	23	of	of	ADP
ijpds-7913	120	24	therapeutic	therapeutic	ADJ
ijpds-7913	120	25	drug	drug	NOUN
ijpds-7913	120	26	monitoring	monitoring	NOUN
ijpds-7913	120	27	in	in	ADP
ijpds-7913	120	28	real	real	ADJ
ijpds-7913	120	29	time	time	NOUN
ijpds-7913	120	30	.	.	PUNCT
ijpds-7913	121	1	subsequent	subsequent	ADJ
ijpds-7913	121	2	research	research	NOUN
ijpds-7913	121	3	must	must	AUX
ijpds-7913	121	4	prioritize	prioritize	VERB
ijpds-7913	121	5	the	the	DET
ijpds-7913	121	6	validation	validation	NOUN
ijpds-7913	121	7	of	of	ADP
ijpds-7913	121	8	tdm	tdm	NOUN
ijpds-7913	121	9	-	-	PUNCT
ijpds-7913	121	10	guided	guide	VERB
ijpds-7913	121	11	methods	method	NOUN
ijpds-7913	121	12	through	through	ADP
ijpds-7913	121	13	extensive	extensive	ADJ
ijpds-7913	121	14	randomized	randomized	ADJ
ijpds-7913	121	15	controlled	control	VERB
ijpds-7913	121	16	trials	trial	NOUN
ijpds-7913	121	17	to	to	PART
ijpds-7913	121	18	enhance	enhance	VERB
ijpds-7913	121	19	the	the	DET
ijpds-7913	121	20	evidence	evidence	NOUN
ijpds-7913	121	21	base	base	NOUN
ijpds-7913	121	22	and	and	CCONJ
ijpds-7913	121	23	optimize	optimize	VERB
ijpds-7913	121	24	dose	dose	NOUN
ijpds-7913	121	25	recommendations	recommendation	NOUN
ijpds-7913	121	26	for	for	ADP
ijpds-7913	121	27	various	various	ADJ
ijpds-7913	121	28	icu	icu	PROPN
ijpds-7913	121	29	populations	population	NOUN
ijpds-7913	121	30	.	.	PUNCT
ijpds-7913	122	1	conclusion	conclusion	NOUN
ijpds-7913	122	2	in	in	ADP
ijpds-7913	122	3	conclusion	conclusion	NOUN
ijpds-7913	122	4	,	,	PUNCT
ijpds-7913	122	5	tdm	tdm	NOUN
ijpds-7913	122	6	in	in	ADP
ijpds-7913	122	7	critical	critical	ADJ
ijpds-7913	122	8	care	care	NOUN
ijpds-7913	122	9	serves	serve	VERB
ijpds-7913	122	10	as	as	ADP
ijpds-7913	122	11	an	an	DET
ijpds-7913	122	12	essential	essential	ADJ
ijpds-7913	122	13	instrument	instrument	NOUN
ijpds-7913	122	14	for	for	ADP
ijpds-7913	122	15	precise	precise	ADJ
ijpds-7913	122	16	dosage	dosage	NOUN
ijpds-7913	122	17	in	in	ADP
ijpds-7913	122	18	patients	patient	NOUN
ijpds-7913	122	19	exhibiting	exhibit	VERB
ijpds-7913	122	20	variable	variable	ADJ
ijpds-7913	122	21	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	122	22	and	and	CCONJ
ijpds-7913	122	23	a	a	DET
ijpds-7913	122	24	heightened	heightened	ADJ
ijpds-7913	122	25	risk	risk	NOUN
ijpds-7913	122	26	of	of	ADP
ijpds-7913	122	27	therapeutic	therapeutic	ADJ
ijpds-7913	122	28	failure	failure	NOUN
ijpds-7913	122	29	or	or	CCONJ
ijpds-7913	122	30	toxicity	toxicity	NOUN
ijpds-7913	122	31	.	.	PUNCT
ijpds-7913	123	1	its	its	PRON
ijpds-7913	123	2	use	use	NOUN
ijpds-7913	123	3	in	in	ADP
ijpds-7913	123	4	antimicrobials	antimicrobial	NOUN
ijpds-7913	123	5	,	,	PUNCT
ijpds-7913	123	6	anticonvulsants	anticonvulsant	NOUN
ijpds-7913	123	7	,	,	PUNCT
ijpds-7913	123	8	immunosuppressants	immunosuppressant	NOUN
ijpds-7913	123	9	and	and	CCONJ
ijpds-7913	123	10	cardiovascular	cardiovascular	ADJ
ijpds-7913	123	11	medications	medication	NOUN
ijpds-7913	123	12	underscores	underscore	VERB
ijpds-7913	123	13	its	its	PRON
ijpds-7913	123	14	extensive	extensive	ADJ
ijpds-7913	123	15	significance	significance	NOUN
ijpds-7913	123	16	within	within	ADP
ijpds-7913	123	17	the	the	DET
ijpds-7913	123	18	icu	icu	PROPN
ijpds-7913	123	19	domain	domain	NOUN
ijpds-7913	123	20	.	.	PUNCT
ijpds-7913	124	1	despite	despite	SCONJ
ijpds-7913	124	2	ongoing	ongoing	ADJ
ijpds-7913	124	3	logistical	logistical	ADJ
ijpds-7913	124	4	and	and	CCONJ
ijpds-7913	124	5	interpretative	interpretative	ADJ
ijpds-7913	124	6	obstacles	obstacle	NOUN
ijpds-7913	124	7	,	,	PUNCT
ijpds-7913	124	8	the	the	DET
ijpds-7913	124	9	incorporation	incorporation	NOUN
ijpds-7913	124	10	of	of	ADP
ijpds-7913	124	11	tdm	tdm	NOUN
ijpds-7913	124	12	into	into	ADP
ijpds-7913	124	13	clinical	clinical	ADJ
ijpds-7913	124	14	workflows	workflow	NOUN
ijpds-7913	124	15	—	—	PUNCT
ijpds-7913	124	16	bolstered	bolster	VERB
ijpds-7913	124	17	by	by	ADP
ijpds-7913	124	18	technology	technology	NOUN
ijpds-7913	124	19	advancements	advancement	NOUN
ijpds-7913	124	20	and	and	CCONJ
ijpds-7913	124	21	global	global	ADJ
ijpds-7913	124	22	consensus	consensus	NOUN
ijpds-7913	124	23	guidelines	guideline	NOUN
ijpds-7913	124	24	—	—	PUNCT
ijpds-7913	124	25	provides	provide	VERB
ijpds-7913	124	26	a	a	DET
ijpds-7913	124	27	pathway	pathway	NOUN
ijpds-7913	124	28	to	to	PART
ijpds-7913	124	29	safer	safe	ADJ
ijpds-7913	124	30	,	,	PUNCT
ijpds-7913	124	31	more	more	ADV
ijpds-7913	124	32	effective	effective	ADJ
ijpds-7913	124	33	,	,	PUNCT
ijpds-7913	124	34	and	and	CCONJ
ijpds-7913	124	35	personalized	personalized	ADJ
ijpds-7913	124	36	medication	medication	NOUN
ijpds-7913	124	37	administration	administration	NOUN
ijpds-7913	124	38	for	for	ADP
ijpds-7913	124	39	critically	critically	ADV
ijpds-7913	124	40	sick	sick	ADJ
ijpds-7913	124	41	patients	patient	NOUN
ijpds-7913	124	42	.	.	PUNCT
ijpds-7913	125	1	references	reference	NOUN
ijpds-7913	125	2	1	1	NUM
ijpds-7913	125	3	.	.	PUNCT
ijpds-7913	126	1	kang	kang	PROPN
ijpds-7913	126	2	js	js	PROPN
ijpds-7913	126	3	,	,	PUNCT
ijpds-7913	126	4	lee	lee	PROPN
ijpds-7913	126	5	mh	mh	PROPN
ijpds-7913	126	6	.	.	PUNCT
ijpds-7913	127	1	overview	overview	NOUN
ijpds-7913	127	2	of	of	ADP
ijpds-7913	127	3	therapeutic	therapeutic	ADJ
ijpds-7913	127	4	drug	drug	NOUN
ijpds-7913	127	5	monitoring	monitoring	NOUN
ijpds-7913	127	6	.	.	PUNCT
ijpds-7913	128	1	korean	korean	PROPN
ijpds-7913	128	2	j	j	PROPN
ijpds-7913	128	3	intern	intern	PROPN
ijpds-7913	128	4	med	me	VERB
ijpds-7913	128	5	.	.	PUNCT
ijpds-7913	129	1	2009	2009	NUM
ijpds-7913	129	2	mar;24(1):1	mar;24(1):1	X
ijpds-7913	129	3	-	-	SYM
ijpds-7913	129	4	10	10	NUM
ijpds-7913	129	5	.	.	PUNCT
ijpds-7913	130	1	2	2	X
ijpds-7913	130	2	.	.	X
ijpds-7913	130	3	karvaly	karvaly	PROPN
ijpds-7913	130	4	gb	gb	PROPN
ijpds-7913	130	5	,	,	PUNCT
ijpds-7913	130	6	vásárhelyi	vásárhelyi	PROPN
ijpds-7913	130	7	b.	b.	PROPN
ijpds-7913	130	8	therapeutic	therapeutic	ADJ
ijpds-7913	130	9	drug	drug	NOUN
ijpds-7913	130	10	monitoring	monitoring	NOUN
ijpds-7913	130	11	and	and	CCONJ
ijpds-7913	130	12	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	130	13	-	-	PUNCT
ijpds-7913	130	14	based	base	VERB
ijpds-7913	130	15	individualization	individualization	NOUN
ijpds-7913	130	16	of	of	ADP
ijpds-7913	130	17	drug	drug	NOUN
ijpds-7913	130	18	therapy	therapy	NOUN
ijpds-7913	130	19	.	.	PUNCT
ijpds-7913	131	1	pharmaceutics	pharmaceutic	NOUN
ijpds-7913	131	2	.	.	PUNCT
ijpds-7913	132	1	2024	2024	NUM
ijpds-7913	132	2	jun	jun	PROPN
ijpds-7913	132	3	11;16(6):792	11;16(6):792	NUM
ijpds-7913	132	4	.	.	PUNCT
ijpds-7913	133	1	3	3	X
ijpds-7913	133	2	.	.	X
ijpds-7913	133	3	alffenaar	alffenaar	NOUN
ijpds-7913	133	4	jc	jc	PROPN
ijpds-7913	133	5	,	,	PUNCT
ijpds-7913	133	6	heysell	heysell	NOUN
ijpds-7913	133	7	sk	sk	VERB
ijpds-7913	133	8	,	,	PUNCT
ijpds-7913	133	9	mpagama	mpagama	NOUN
ijpds-7913	133	10	sg	sg	PROPN
ijpds-7913	133	11	.	.	PUNCT
ijpds-7913	134	1	therapeutic	therapeutic	ADJ
ijpds-7913	134	2	drug	drug	NOUN
ijpds-7913	134	3	monitoring	monitoring	NOUN
ijpds-7913	134	4	:	:	PUNCT
ijpds-7913	134	5	the	the	DET
ijpds-7913	134	6	need	need	NOUN
ijpds-7913	134	7	for	for	ADP
ijpds-7913	134	8	practical	practical	ADJ
ijpds-7913	134	9	guidance	guidance	NOUN
ijpds-7913	134	10	.	.	PUNCT
ijpds-7913	135	1	clin	clin	PROPN
ijpds-7913	135	2	infect	infect	PROPN
ijpds-7913	135	3	dis	dis	PROPN
ijpds-7913	135	4	.	.	PUNCT
ijpds-7913	136	1	2019	2019	NUM
ijpds-7913	136	2	mar	mar	PROPN
ijpds-7913	136	3	5;68(6):1065	5;68(6):1065	PROPN
ijpds-7913	136	4	-	-	PUNCT
ijpds-7913	136	5	1066	1066	NUM
ijpds-7913	136	6	.	.	PUNCT
ijpds-7913	137	1	4	4	X
ijpds-7913	137	2	.	.	X
ijpds-7913	137	3	wicha	wicha	PROPN
ijpds-7913	137	4	sg	sg	PROPN
ijpds-7913	137	5	,	,	PUNCT
ijpds-7913	137	6	märtson	märtson	PROPN
ijpds-7913	137	7	ag	ag	PROPN
ijpds-7913	137	8	,	,	PUNCT
ijpds-7913	137	9	nielsen	nielsen	PROPN
ijpds-7913	137	10	ei	ei	PROPN
ijpds-7913	137	11	,	,	PUNCT
ijpds-7913	137	12	koch	koch	PROPN
ijpds-7913	137	13	bcp	bcp	PROPN
ijpds-7913	137	14	,	,	PUNCT
ijpds-7913	137	15	friberg	friberg	PROPN
ijpds-7913	137	16	le	le	PROPN
ijpds-7913	137	17	,	,	PUNCT
ijpds-7913	137	18	alffenaar	alffenaar	PROPN
ijpds-7913	137	19	jw	jw	PROPN
ijpds-7913	137	20	,	,	PUNCT
ijpds-7913	137	21	minichmayr	minichmayr	PROPN
ijpds-7913	137	22	ik	ik	PROPN
ijpds-7913	137	23	;	;	PUNCT
ijpds-7913	137	24	international	international	ADJ
ijpds-7913	137	25	society	society	NOUN
ijpds-7913	137	26	of	of	ADP
ijpds-7913	137	27	antiinfective	antiinfective	ADJ
ijpds-7913	137	28	pharmacology	pharmacology	NOUN
ijpds-7913	137	29	(	(	PUNCT
ijpds-7913	137	30	isap	isap	PROPN
ijpds-7913	137	31	)	)	PUNCT
ijpds-7913	137	32	,	,	PUNCT
ijpds-7913	137	33	the	the	DET
ijpds-7913	137	34	pk	pk	PROPN
ijpds-7913	137	35	/	/	SYM
ijpds-7913	137	36	pd	pd	PROPN
ijpds-7913	137	37	study	study	NOUN
ijpds-7913	137	38	group	group	NOUN
ijpds-7913	137	39	of	of	ADP
ijpds-7913	137	40	the	the	DET
ijpds-7913	137	41	european	european	PROPN
ijpds-7913	137	42	society	society	NOUN
ijpds-7913	137	43	of	of	ADP
ijpds-7913	137	44	clinical	clinical	ADJ
ijpds-7913	137	45	microbiology	microbiology	NOUN
ijpds-7913	137	46	,	,	PUNCT
ijpds-7913	137	47	infectious	infectious	ADJ
ijpds-7913	137	48	diseases	disease	NOUN
ijpds-7913	137	49	(	(	PUNCT
ijpds-7913	137	50	epasg	epasg	PROPN
ijpds-7913	137	51	)	)	PUNCT
ijpds-7913	137	52	.	.	PUNCT
ijpds-7913	138	1	from	from	ADP
ijpds-7913	138	2	therapeutic	therapeutic	ADJ
ijpds-7913	138	3	drug	drug	NOUN
ijpds-7913	138	4	monitoring	monitoring	NOUN
ijpds-7913	138	5	to	to	ADP
ijpds-7913	138	6	model	model	NOUN
ijpds-7913	138	7	-	-	PUNCT
ijpds-7913	138	8	informed	inform	VERB
ijpds-7913	138	9	precision	precision	NOUN
ijpds-7913	138	10	dosing	dose	VERB
ijpds-7913	138	11	for	for	ADP
ijpds-7913	138	12	antibiotics	antibiotic	NOUN
ijpds-7913	138	13	.	.	PUNCT
ijpds-7913	139	1	clin	clin	PROPN
ijpds-7913	139	2	pharmacol	pharmacol	PROPN
ijpds-7913	139	3	ther	ther	ADV
ijpds-7913	139	4	.	.	PUNCT
ijpds-7913	140	1	2021	2021	NUM
ijpds-7913	140	2	apr;109(4):928	apr;109(4):928	NOUN
ijpds-7913	140	3	-	-	SYM
ijpds-7913	140	4	941	941	NUM
ijpds-7913	140	5	.	.	PUNCT
ijpds-7913	141	1	5	5	NUM
ijpds-7913	141	2	.	.	PUNCT
ijpds-7913	142	1	li	li	PROPN
ijpds-7913	142	2	x	x	PROPN
ijpds-7913	142	3	,	,	PUNCT
ijpds-7913	142	4	song	song	NOUN
ijpds-7913	142	5	z	z	PROPN
ijpds-7913	142	6	,	,	PUNCT
ijpds-7913	142	7	yi	yi	PROPN
ijpds-7913	142	8	z	z	PROPN
ijpds-7913	142	9	,	,	PUNCT
ijpds-7913	142	10	qin	qin	PROPN
ijpds-7913	142	11	j	j	PROPN
ijpds-7913	142	12	,	,	PUNCT
ijpds-7913	142	13	jiang	jiang	PROPN
ijpds-7913	142	14	d	d	PROPN
ijpds-7913	142	15	,	,	PUNCT
ijpds-7913	142	16	wang	wang	PROPN
ijpds-7913	142	17	z	z	PROPN
ijpds-7913	142	18	,	,	PUNCT
ijpds-7913	142	19	li	li	PROPN
ijpds-7913	142	20	h	h	PROPN
ijpds-7913	142	21	,	,	PUNCT
ijpds-7913	142	22	zhao	zhao	PROPN
ijpds-7913	142	23	r.	r.	PROPN
ijpds-7913	142	24	therapeutic	therapeutic	ADJ
ijpds-7913	142	25	drug	drug	NOUN
ijpds-7913	142	26	monitoring	monitoring	NOUN
ijpds-7913	142	27	guidelines	guideline	NOUN
ijpds-7913	142	28	in	in	ADP
ijpds-7913	142	29	oncology	oncology	NOUN
ijpds-7913	142	30	:	:	PUNCT
ijpds-7913	142	31	what	what	PRON
ijpds-7913	142	32	do	do	AUX
ijpds-7913	142	33	we	we	PRON
ijpds-7913	142	34	know	know	VERB
ijpds-7913	142	35	and	and	CCONJ
ijpds-7913	142	36	how	how	SCONJ
ijpds-7913	142	37	to	to	PART
ijpds-7913	142	38	move	move	VERB
ijpds-7913	142	39	forward	forward	ADV
ijpds-7913	142	40	?	?	PUNCT
ijpds-7913	143	1	insights	insight	NOUN
ijpds-7913	143	2	from	from	ADP
ijpds-7913	143	3	a	a	DET
ijpds-7913	143	4	systematic	systematic	ADJ
ijpds-7913	143	5	review	review	NOUN
ijpds-7913	143	6	.	.	PUNCT
ijpds-7913	144	1	ther	ther	PROPN
ijpds-7913	144	2	adv	adv	PROPN
ijpds-7913	144	3	med	med	PROPN
ijpds-7913	144	4	oncol	oncol	ADJ
ijpds-7913	144	5	.	.	PUNCT
ijpds-7913	145	1	2024	2024	NUM
ijpds-7913	145	2	may	may	AUX
ijpds-7913	145	3	27;16:17588359241250130	27;16:17588359241250130	NUM
ijpds-7913	145	4	.	.	NOUN
ijpds-7913	146	1	6	6	NUM
ijpds-7913	146	2	.	.	PUNCT
ijpds-7913	146	3	morales	morale	NOUN
ijpds-7913	146	4	castro	castro	PROPN
ijpds-7913	146	5	d	d	PROPN
ijpds-7913	146	6	,	,	PUNCT
ijpds-7913	146	7	dresser	dresser	NOUN
ijpds-7913	146	8	l	l	PROPN
ijpds-7913	146	9	,	,	PUNCT
ijpds-7913	146	10	granton	granton	PROPN
ijpds-7913	146	11	j	j	PROPN
ijpds-7913	146	12	,	,	PUNCT
ijpds-7913	146	13	fan	fan	PROPN
ijpds-7913	146	14	e.	e.	PROPN
ijpds-7913	146	15	pharmacokinetic	pharmacokinetic	PROPN
ijpds-7913	146	16	alterations	alteration	NOUN
ijpds-7913	146	17	associated	associate	VERB
ijpds-7913	146	18	with	with	ADP
ijpds-7913	146	19	critical	critical	ADJ
ijpds-7913	146	20	illness	illness	NOUN
ijpds-7913	146	21	.	.	PUNCT
ijpds-7913	147	1	clin	clin	PROPN
ijpds-7913	147	2	pharmacokinet	pharmacokinet	PROPN
ijpds-7913	147	3	.	.	PUNCT
ijpds-7913	148	1	2023	2023	NUM
ijpds-7913	148	2	feb;62(2):209	feb;62(2):209	NOUN
ijpds-7913	148	3	-	-	PUNCT
ijpds-7913	148	4	220	220	NUM
ijpds-7913	148	5	.	.	PUNCT
ijpds-7913	149	1	7	7	X
ijpds-7913	149	2	.	.	X
ijpds-7913	150	1	wojciechowski	wojciechowski	PROPN
ijpds-7913	150	2	d	d	NOUN
ijpds-7913	150	3	,	,	PUNCT
ijpds-7913	150	4	wiseman	wiseman	PROPN
ijpds-7913	150	5	a.	a.	PROPN
ijpds-7913	150	6	long	long	ADJ
ijpds-7913	150	7	-	-	PUNCT
ijpds-7913	150	8	term	term	NOUN
ijpds-7913	150	9	immunosuppression	immunosuppression	NOUN
ijpds-7913	150	10	management	management	NOUN
ijpds-7913	150	11	:	:	PUNCT
ijpds-7913	150	12	opportunities	opportunity	NOUN
ijpds-7913	150	13	and	and	CCONJ
ijpds-7913	150	14	uncertainties	uncertainty	NOUN
ijpds-7913	150	15	.	.	PUNCT
ijpds-7913	151	1	clin	clin	PROPN
ijpds-7913	151	2	j	j	PROPN
ijpds-7913	151	3	am	be	AUX
ijpds-7913	151	4	soc	soc	NOUN
ijpds-7913	151	5	nephrol	nephrol	NOUN
ijpds-7913	151	6	.	.	PUNCT
ijpds-7913	152	1	2021	2021	NUM
ijpds-7913	152	2	aug;16(8):12641271	aug;16(8):12641271	PROPN
ijpds-7913	152	3	.	.	PROPN
ijpds-7913	152	4	8	8	NUM
ijpds-7913	152	5	.	.	PUNCT
ijpds-7913	153	1	tanaka	tanaka	PROPN
ijpds-7913	153	2	r.	r.	PROPN
ijpds-7913	153	3	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	153	4	variability	variability	NOUN
ijpds-7913	153	5	and	and	CCONJ
ijpds-7913	153	6	significance	significance	NOUN
ijpds-7913	153	7	of	of	ADP
ijpds-7913	153	8	therapeutic	therapeutic	ADJ
ijpds-7913	153	9	drug	drug	NOUN
ijpds-7913	153	10	monitoring	monitoring	NOUN
ijpds-7913	153	11	for	for	ADP
ijpds-7913	153	12	broad	broad	ADJ
ijpds-7913	153	13	-	-	PUNCT
ijpds-7913	153	14	spectrum	spectrum	NOUN
ijpds-7913	153	15	antimicrobials	antimicrobial	NOUN
ijpds-7913	153	16	in	in	ADP
ijpds-7913	153	17	critically	critically	ADV
ijpds-7913	153	18	ill	ill	ADJ
ijpds-7913	153	19	patients	patient	NOUN
ijpds-7913	153	20	.	.	PUNCT
ijpds-7913	154	1	j	j	PROPN
ijpds-7913	154	2	pharm	pharm	PROPN
ijpds-7913	154	3	health	health	PROPN
ijpds-7913	154	4	care	care	PROPN
ijpds-7913	154	5	sci	sci	PROPN
ijpds-7913	154	6	.	.	PROPN
ijpds-7913	154	7	2025	2025	NUM
ijpds-7913	154	8	mar	mar	PROPN
ijpds-7913	154	9	17;11(1):21	17;11(1):21	PROPN
ijpds-7913	154	10	.	.	PUNCT
ijpds-7913	155	1	9	9	X
ijpds-7913	155	2	.	.	X
ijpds-7913	155	3	llor	llor	PROPN
ijpds-7913	155	4	c	c	PROPN
ijpds-7913	155	5	,	,	PUNCT
ijpds-7913	155	6	bjerrum	bjerrum	PROPN
ijpds-7913	155	7	l.	l.	PROPN
ijpds-7913	155	8	antimicrobial	antimicrobial	PROPN
ijpds-7913	155	9	resistance	resistance	NOUN
ijpds-7913	155	10	:	:	PUNCT
ijpds-7913	155	11	risk	risk	NOUN
ijpds-7913	155	12	associated	associate	VERB
ijpds-7913	155	13	with	with	ADP
ijpds-7913	155	14	antibiotic	antibiotic	ADJ
ijpds-7913	155	15	overuse	overuse	NOUN
ijpds-7913	155	16	and	and	CCONJ
ijpds-7913	155	17	initiatives	initiative	NOUN
ijpds-7913	155	18	to	to	PART
ijpds-7913	155	19	reduce	reduce	VERB
ijpds-7913	155	20	the	the	DET
ijpds-7913	155	21	problem	problem	NOUN
ijpds-7913	155	22	.	.	PUNCT
ijpds-7913	156	1	ther	ther	VERB
ijpds-7913	156	2	adv	adv	PROPN
ijpds-7913	156	3	drug	drug	PROPN
ijpds-7913	156	4	saf	saf	PROPN
ijpds-7913	156	5	.	.	PROPN
ijpds-7913	156	6	2014	2014	NUM
ijpds-7913	156	7	dec;5(6):229	dec;5(6):229	PROPN
ijpds-7913	156	8	-	-	PUNCT
ijpds-7913	156	9	41	41	NUM
ijpds-7913	156	10	.	.	PUNCT
ijpds-7913	157	1	10	10	NUM
ijpds-7913	157	2	.	.	PUNCT
ijpds-7913	158	1	evans	evans	PROPN
ijpds-7913	158	2	we	we	PRON
ijpds-7913	158	3	,	,	PUNCT
ijpds-7913	158	4	johnson	johnson	PROPN
ijpds-7913	158	5	ja	ja	PROPN
ijpds-7913	158	6	.	.	PROPN
ijpds-7913	158	7	pharmacogenomics	pharmacogenomics	PROPN
ijpds-7913	158	8	:	:	PUNCT
ijpds-7913	158	9	the	the	DET
ijpds-7913	158	10	inherited	inherited	ADJ
ijpds-7913	158	11	basis	basis	NOUN
ijpds-7913	158	12	for	for	ADP
ijpds-7913	158	13	interindividual	interindividual	ADJ
ijpds-7913	158	14	differences	difference	NOUN
ijpds-7913	158	15	in	in	ADP
ijpds-7913	158	16	drug	drug	NOUN
ijpds-7913	158	17	response	response	NOUN
ijpds-7913	158	18	.	.	PUNCT
ijpds-7913	159	1	annu	annu	PROPN
ijpds-7913	159	2	rev	rev	VERB
ijpds-7913	159	3	genomics	genomics	PROPN
ijpds-7913	159	4	hum	hum	PROPN
ijpds-7913	159	5	genet	genet	PROPN
ijpds-7913	159	6	.	.	PUNCT
ijpds-7913	160	1	2001;2:9	2001;2:9	X
ijpds-7913	160	2	-	-	PUNCT
ijpds-7913	160	3	39	39	NUM
ijpds-7913	160	4	.	.	PUNCT
ijpds-7913	161	1	11	11	NUM
ijpds-7913	161	2	.	.	PUNCT
ijpds-7913	161	3	gross	gross	ADJ
ijpds-7913	161	4	as	as	ADP
ijpds-7913	161	5	.	.	PUNCT
ijpds-7913	161	6	best	good	ADJ
ijpds-7913	161	7	practice	practice	NOUN
ijpds-7913	161	8	in	in	ADP
ijpds-7913	161	9	therapeutic	therapeutic	ADJ
ijpds-7913	161	10	drug	drug	NOUN
ijpds-7913	161	11	monitoring	monitoring	NOUN
ijpds-7913	161	12	.	.	PUNCT
ijpds-7913	162	1	br	br	PROPN
ijpds-7913	163	1	j	j	PROPN
ijpds-7913	163	2	clin	clin	PROPN
ijpds-7913	163	3	pharmacol	pharmacol	PROPN
ijpds-7913	163	4	.	.	PUNCT
ijpds-7913	164	1	1998	1998	NUM
ijpds-7913	164	2	aug;46(2):95	aug;46(2):95	NOUN
ijpds-7913	164	3	-	-	SYM
ijpds-7913	164	4	9	9	NUM
ijpds-7913	164	5	.	.	NOUN
ijpds-7913	164	6	12	12	NUM
ijpds-7913	164	7	.	.	PUNCT
ijpds-7913	165	1	rabi	rabi	NOUN
ijpds-7913	165	2	r	r	PROPN
ijpds-7913	165	3	,	,	PUNCT
ijpds-7913	165	4	alsaid	alsaid	PROPN
ijpds-7913	165	5	rm	rm	PROPN
ijpds-7913	165	6	,	,	PUNCT
ijpds-7913	165	7	matar	matar	PROPN
ijpds-7913	165	8	an	an	PROPN
ijpds-7913	165	9	,	,	PUNCT
ijpds-7913	165	10	dawabsheh	dawabsheh	NOUN
ijpds-7913	165	11	y	y	PROPN
ijpds-7913	165	12	,	,	PUNCT
ijpds-7913	165	13	abu	abu	PROPN
ijpds-7913	165	14	gaber	gaber	PROPN
ijpds-7913	165	15	d.	d.	PROPN
ijpds-7913	165	16	the	the	DET
ijpds-7913	165	17	role	role	NOUN
ijpds-7913	165	18	of	of	ADP
ijpds-7913	165	19	serum	serum	NOUN
ijpds-7913	165	20	albumin	albumin	NOUN
ijpds-7913	165	21	in	in	ADP
ijpds-7913	165	22	critical	critical	ADJ
ijpds-7913	165	23	illness	illness	NOUN
ijpds-7913	165	24	,	,	PUNCT
ijpds-7913	165	25	predicting	predict	VERB
ijpds-7913	165	26	poor	poor	ADJ
ijpds-7913	165	27	outcomes	outcome	NOUN
ijpds-7913	165	28	,	,	PUNCT
ijpds-7913	165	29	and	and	CCONJ
ijpds-7913	165	30	exploring	explore	VERB
ijpds-7913	165	31	the	the	DET
ijpds-7913	165	32	therapeutic	therapeutic	ADJ
ijpds-7913	165	33	potential	potential	NOUN
ijpds-7913	165	34	of	of	ADP
ijpds-7913	165	35	albumin	albumin	ADJ
ijpds-7913	165	36	supplementation	supplementation	NOUN
ijpds-7913	165	37	.	.	PUNCT
ijpds-7913	166	1	sci	sci	PROPN
ijpds-7913	166	2	prog	prog	PROPN
ijpds-7913	166	3	.	.	PUNCT
ijpds-7913	167	1	2024	2024	NUM
ijpds-7913	167	2	julsep;107(3):368504241274023	julsep;107(3):368504241274023	PROPN
ijpds-7913	167	3	.	.	PROPN
ijpds-7913	168	1	13	13	NUM
ijpds-7913	168	2	.	.	PUNCT
ijpds-7913	169	1	akinosoglou	akinosoglou	PROPN
ijpds-7913	169	2	k	k	PROPN
ijpds-7913	169	3	,	,	PUNCT
ijpds-7913	169	4	schinas	schina	VERB
ijpds-7913	169	5	g	g	PROPN
ijpds-7913	169	6	,	,	PUNCT
ijpds-7913	169	7	almyroudi	almyroudi	PROPN
ijpds-7913	169	8	mp	mp	PROPN
ijpds-7913	169	9	,	,	PUNCT
ijpds-7913	169	10	gogos	gogos	PROPN
ijpds-7913	169	11	c	c	PROPN
ijpds-7913	169	12	,	,	PUNCT
ijpds-7913	169	13	dimopoulos	dimopoulo	NOUN
ijpds-7913	169	14	g.	g.	VERB
ijpds-7913	169	15	the	the	DET
ijpds-7913	169	16	impact	impact	NOUN
ijpds-7913	169	17	of	of	ADP
ijpds-7913	169	18	age	age	NOUN
ijpds-7913	169	19	on	on	ADP
ijpds-7913	169	20	intensive	intensive	ADJ
ijpds-7913	169	21	care	care	NOUN
ijpds-7913	169	22	.	.	PUNCT
ijpds-7913	170	1	ageing	age	VERB
ijpds-7913	170	2	res	re	NOUN
ijpds-7913	170	3	rev	rev	PROPN
ijpds-7913	170	4	.	.	PROPN
ijpds-7913	170	5	2023	2023	NUM
ijpds-7913	170	6	feb;84:101832	feb;84:101832	NOUN
ijpds-7913	170	7	.	.	PUNCT
ijpds-7913	171	1	14	14	NUM
ijpds-7913	171	2	.	.	PUNCT
ijpds-7913	172	1	subbarayan	subbarayan	PROPN
ijpds-7913	172	2	b	b	PROPN
ijpds-7913	172	3	,	,	PUNCT
ijpds-7913	172	4	vivek	vivek	PROPN
ijpds-7913	172	5	v	v	NOUN
ijpds-7913	172	6	,	,	PUNCT
ijpds-7913	172	7	kuppuswamy	kuppuswamy	PROPN
ijpds-7913	172	8	mk	mk	PROPN
ijpds-7913	172	9	.	.	PUNCT
ijpds-7913	173	1	renal	renal	ADJ
ijpds-7913	173	2	replacement	replacement	NOUN
ijpds-7913	173	3	therapy	therapy	NOUN
ijpds-7913	173	4	during	during	ADP
ijpds-7913	173	5	extracorporeal	extracorporeal	ADJ
ijpds-7913	173	6	membrane	membrane	NOUN
ijpds-7913	173	7	oxygenation	oxygenation	NOUN
ijpds-7913	173	8	.	.	PUNCT
ijpds-7913	174	1	indian	indian	PROPN
ijpds-7913	174	2	j	j	PROPN
ijpds-7913	174	3	thorac	thorac	PROPN
ijpds-7913	174	4	cardiovasc	cardiovasc	PROPN
ijpds-7913	174	5	surg	surg	PROPN
ijpds-7913	174	6	.	.	PUNCT
ijpds-7913	175	1	2021	2021	NUM
ijpds-7913	175	2	apr;37(suppl	apr;37(suppl	PROPN
ijpds-7913	175	3	2):261	2):261	PROPN
ijpds-7913	175	4	-	-	PUNCT
ijpds-7913	175	5	266	266	NUM
ijpds-7913	175	6	.	.	PUNCT
ijpds-7913	176	1	15	15	NUM
ijpds-7913	176	2	.	.	X
ijpds-7913	177	1	fang	fang	PROPN
ijpds-7913	177	2	z	z	PROPN
ijpds-7913	177	3	,	,	PUNCT
ijpds-7913	177	4	zhang	zhang	PROPN
ijpds-7913	177	5	h	h	PROPN
ijpds-7913	177	6	,	,	PUNCT
ijpds-7913	177	7	guo	guo	PROPN
ijpds-7913	177	8	j	j	PROPN
ijpds-7913	177	9	,	,	PUNCT
ijpds-7913	177	10	guo	guo	PROPN
ijpds-7913	177	11	j.	j.	PROPN
ijpds-7913	177	12	overview	overview	NOUN
ijpds-7913	177	13	of	of	ADP
ijpds-7913	177	14	therapeutic	therapeutic	ADJ
ijpds-7913	177	15	drug	drug	NOUN
ijpds-7913	177	16	monitoring	monitoring	NOUN
ijpds-7913	177	17	and	and	CCONJ
ijpds-7913	177	18	clinical	clinical	ADJ
ijpds-7913	177	19	practice	practice	NOUN
ijpds-7913	177	20	.	.	PUNCT
ijpds-7913	178	1	talanta	talanta	ADJ
ijpds-7913	178	2	.	.	PUNCT
ijpds-7913	179	1	2024	2024	NUM
ijpds-7913	179	2	jan	jan	PROPN
ijpds-7913	179	3	1;266(pt	1;266(pt	NUM
ijpds-7913	179	4	1):124996	1):124996	NUM
ijpds-7913	179	5	.	.	PUNCT
ijpds-7913	180	1	16	16	NUM
ijpds-7913	180	2	.	.	PUNCT
ijpds-7913	181	1	póvoa	póvoa	PROPN
ijpds-7913	181	2	p	p	X
ijpds-7913	181	3	,	,	PUNCT
ijpds-7913	181	4	moniz	moniz	PROPN
ijpds-7913	181	5	p	p	PROPN
ijpds-7913	181	6	,	,	PUNCT
ijpds-7913	181	7	pereira	pereira	PROPN
ijpds-7913	181	8	jg	jg	PROPN
ijpds-7913	181	9	,	,	PUNCT
ijpds-7913	181	10	coelho	coelho	PROPN
ijpds-7913	181	11	l.	l.	PROPN
ijpds-7913	181	12	optimizing	optimize	VERB
ijpds-7913	181	13	antimicrobial	antimicrobial	ADJ
ijpds-7913	181	14	drug	drug	NOUN
ijpds-7913	181	15	dosing	dose	VERB
ijpds-7913	181	16	in	in	ADP
ijpds-7913	181	17	critically	critically	ADV
ijpds-7913	181	18	ill	ill	ADJ
ijpds-7913	181	19	patients	patient	NOUN
ijpds-7913	181	20	.	.	PUNCT
ijpds-7913	182	1	microorganisms	microorganism	NOUN
ijpds-7913	182	2	.	.	PUNCT
ijpds-7913	183	1	2021	2021	NUM
ijpds-7913	183	2	jun	jun	PROPN
ijpds-7913	183	3	28;9(7):1401	28;9(7):1401	NOUN
ijpds-7913	183	4	.	.	PUNCT
ijpds-7913	184	1	17	17	NUM
ijpds-7913	184	2	.	.	PUNCT
ijpds-7913	185	1	pereira	pereira	PROPN
ijpds-7913	185	2	jg	jg	PROPN
ijpds-7913	185	3	,	,	PUNCT
ijpds-7913	185	4	fernandes	fernandes	PROPN
ijpds-7913	185	5	j	j	PROPN
ijpds-7913	185	6	,	,	PUNCT
ijpds-7913	185	7	duarte	duarte	PROPN
ijpds-7913	185	8	ar	ar	PROPN
ijpds-7913	185	9	,	,	PUNCT
ijpds-7913	185	10	fernandes	fernandes	PROPN
ijpds-7913	185	11	sm	sm	PROPN
ijpds-7913	185	12	.	.	PUNCT
ijpds-7913	185	13	β	β	NOUN
ijpds-7913	185	14	-	-	NOUN
ijpds-7913	185	15	lactam	lactam	NOUN
ijpds-7913	185	16	dosing	dose	VERB
ijpds-7913	185	17	in	in	ADP
ijpds-7913	185	18	critical	critical	ADJ
ijpds-7913	185	19	patients	patient	NOUN
ijpds-7913	185	20	:	:	PUNCT
ijpds-7913	185	21	a	a	DET
ijpds-7913	185	22	narrative	narrative	NOUN
ijpds-7913	185	23	review	review	NOUN
ijpds-7913	185	24	of	of	ADP
ijpds-7913	185	25	optimal	optimal	ADJ
ijpds-7913	185	26	efficacy	efficacy	NOUN
ijpds-7913	185	27	and	and	CCONJ
ijpds-7913	185	28	the	the	DET
ijpds-7913	185	29	prevention	prevention	NOUN
ijpds-7913	185	30	of	of	ADP
ijpds-7913	185	31	resistance	resistance	NOUN
ijpds-7913	185	32	and	and	CCONJ
ijpds-7913	185	33	toxicity	toxicity	NOUN
ijpds-7913	185	34	.	.	PUNCT
ijpds-7913	186	1	antibiotics	antibiotic	NOUN
ijpds-7913	186	2	(	(	PUNCT
ijpds-7913	186	3	basel	basel	PROPN
ijpds-7913	186	4	)	)	PUNCT
ijpds-7913	186	5	.	.	PUNCT
ijpds-7913	187	1	2022	2022	NUM
ijpds-7913	187	2	dec	dec	PROPN
ijpds-7913	187	3	18;11(12):1839	18;11(12):1839	NUM
ijpds-7913	187	4	.	.	PROPN
ijpds-7913	187	5	18	18	NUM
ijpds-7913	187	6	.	.	PUNCT
ijpds-7913	188	1	matsumoto	matsumoto	PROPN
ijpds-7913	188	2	k	k	PROPN
ijpds-7913	188	3	,	,	PUNCT
ijpds-7913	188	4	oda	oda	PROPN
ijpds-7913	188	5	k	k	PROPN
ijpds-7913	188	6	,	,	PUNCT
ijpds-7913	188	7	shoji	shoji	PROPN
ijpds-7913	188	8	k	k	PROPN
ijpds-7913	188	9	,	,	PUNCT
ijpds-7913	188	10	hanai	hanai	NOUN
ijpds-7913	188	11	y	y	PROPN
ijpds-7913	188	12	,	,	PUNCT
ijpds-7913	188	13	takahashi	takahashi	PROPN
ijpds-7913	188	14	y	y	PROPN
ijpds-7913	188	15	,	,	PUNCT
ijpds-7913	188	16	fujii	fujii	PROPN
ijpds-7913	188	17	s	s	PROPN
ijpds-7913	188	18	,	,	PUNCT
ijpds-7913	188	19	hamada	hamada	PROPN
ijpds-7913	188	20	y	y	PROPN
ijpds-7913	188	21	,	,	PUNCT
ijpds-7913	188	22	kimura	kimura	PROPN
ijpds-7913	188	23	t	t	PROPN
ijpds-7913	188	24	,	,	PUNCT
ijpds-7913	188	25	mayumi	mayumi	PROPN
ijpds-7913	188	26	t	t	PROPN
ijpds-7913	188	27	,	,	PUNCT
ijpds-7913	188	28	ueda	ueda	PROPN
ijpds-7913	188	29	t	t	PROPN
ijpds-7913	188	30	,	,	PUNCT
ijpds-7913	188	31	nakajima	nakajima	PROPN
ijpds-7913	188	32	k	k	PROPN
ijpds-7913	188	33	,	,	PUNCT
ijpds-7913	188	34	takesue	takesue	PROPN
ijpds-7913	188	35	y.	y.	PROPN
ijpds-7913	188	36	clinical	clinical	ADJ
ijpds-7913	188	37	practice	practice	NOUN
ijpds-7913	188	38	guidelines	guideline	NOUN
ijpds-7913	188	39	for	for	ADP
ijpds-7913	188	40	therapeutic	therapeutic	ADJ
ijpds-7913	188	41	drug	drug	NOUN
ijpds-7913	188	42	monitoring	monitoring	NOUN
ijpds-7913	188	43	of	of	ADP
ijpds-7913	188	44	vancomycin	vancomycin	PROPN
ijpds-7913	188	45	in	in	ADP
ijpds-7913	188	46	the	the	DET
ijpds-7913	188	47	framework	framework	NOUN
ijpds-7913	188	48	of	of	ADP
ijpds-7913	188	49	modelinformed	modelinforme	VERB
ijpds-7913	188	50	precision	precision	NOUN
ijpds-7913	188	51	dosing	dose	VERB
ijpds-7913	188	52	:	:	PUNCT
ijpds-7913	188	53	a	a	DET
ijpds-7913	188	54	consensus	consensus	NOUN
ijpds-7913	188	55	review	review	NOUN
ijpds-7913	188	56	by	by	ADP
ijpds-7913	188	57	the	the	DET
ijpds-7913	188	58	japanese	japanese	ADJ
ijpds-7913	188	59	society	society	NOUN
ijpds-7913	188	60	of	of	ADP
ijpds-7913	188	61	chemotherapy	chemotherapy	NOUN
ijpds-7913	188	62	and	and	CCONJ
ijpds-7913	188	63	the	the	DET
ijpds-7913	188	64	japanese	japanese	ADJ
ijpds-7913	188	65	society	society	NOUN
ijpds-7913	188	66	of	of	ADP
ijpds-7913	188	67	therapeutic	therapeutic	ADJ
ijpds-7913	188	68	drug	drug	NOUN
ijpds-7913	188	69	monitoring	monitoring	NOUN
ijpds-7913	188	70	.	.	PUNCT
ijpds-7913	189	1	pharmaceutics	pharmaceutic	NOUN
ijpds-7913	189	2	.	.	PUNCT
ijpds-7913	190	1	2022	2022	NUM
ijpds-7913	190	2	feb	feb	PROPN
ijpds-7913	190	3	23;14(3):489	23;14(3):489	NUM
ijpds-7913	190	4	.	.	PUNCT
ijpds-7913	191	1	19	19	NUM
ijpds-7913	191	2	.	.	PROPN
ijpds-7913	191	3	ashbee	ashbee	PROPN
ijpds-7913	191	4	hr	hr	PROPN
ijpds-7913	191	5	,	,	PUNCT
ijpds-7913	191	6	barnes	barnes	PROPN
ijpds-7913	191	7	ra	ra	PROPN
ijpds-7913	191	8	,	,	PUNCT
ijpds-7913	191	9	johnson	johnson	PROPN
ijpds-7913	191	10	em	em	PRON
ijpds-7913	191	11	,	,	PUNCT
ijpds-7913	191	12	richardson	richardson	PROPN
ijpds-7913	191	13	md	md	PROPN
ijpds-7913	191	14	,	,	PUNCT
ijpds-7913	191	15	gorton	gorton	PROPN
ijpds-7913	191	16	r	r	PROPN
ijpds-7913	191	17	,	,	PUNCT
ijpds-7913	191	18	hope	hope	NOUN
ijpds-7913	191	19	ww	ww	PROPN
ijpds-7913	191	20	.	.	PROPN
ijpds-7913	192	1	therapeutic	therapeutic	ADJ
ijpds-7913	192	2	drug	drug	NOUN
ijpds-7913	192	3	monitoring	monitoring	NOUN
ijpds-7913	192	4	(	(	PUNCT
ijpds-7913	192	5	tdm	tdm	NOUN
ijpds-7913	192	6	)	)	PUNCT
ijpds-7913	192	7	of	of	ADP
ijpds-7913	192	8	antifungal	antifungal	ADJ
ijpds-7913	192	9	agents	agent	NOUN
ijpds-7913	192	10	:	:	PUNCT
ijpds-7913	192	11	guidelines	guideline	NOUN
ijpds-7913	192	12	from	from	ADP
ijpds-7913	192	13	the	the	DET
ijpds-7913	192	14	british	british	ADJ
ijpds-7913	192	15	society	society	NOUN
ijpds-7913	192	16	for	for	ADP
ijpds-7913	192	17	medical	medical	ADJ
ijpds-7913	192	18	mycology	mycology	NOUN
ijpds-7913	192	19	.	.	PUNCT
ijpds-7913	193	1	j	j	PROPN
ijpds-7913	193	2	antimicrob	antimicrob	PROPN
ijpds-7913	193	3	chemother	chemother	PROPN
ijpds-7913	193	4	.	.	PUNCT
ijpds-7913	194	1	2014	2014	NUM
ijpds-7913	194	2	may;69(5):1162	may;69(5):1162	NOUN
ijpds-7913	194	3	-	-	PUNCT
ijpds-7913	194	4	76	76	NUM
ijpds-7913	194	5	.	.	PUNCT
ijpds-7913	195	1	20	20	NUM
ijpds-7913	195	2	.	.	X
ijpds-7913	196	1	lanckohr	lanckohr	PROPN
ijpds-7913	196	2	c	c	PROPN
ijpds-7913	196	3	,	,	PUNCT
ijpds-7913	196	4	boeing	boeing	PROPN
ijpds-7913	196	5	c	c	PROPN
ijpds-7913	196	6	,	,	PUNCT
ijpds-7913	196	7	de	de	PROPN
ijpds-7913	196	8	waele	waele	PROPN
ijpds-7913	196	9	jj	jj	PROPN
ijpds-7913	196	10	,	,	PUNCT
ijpds-7913	196	11	de	de	X
ijpds-7913	196	12	lange	lange	PROPN
ijpds-7913	196	13	dw	dw	PROPN
ijpds-7913	196	14	,	,	PUNCT
ijpds-7913	196	15	schouten	schouten	PROPN
ijpds-7913	196	16	j	j	PROPN
ijpds-7913	196	17	,	,	PUNCT
ijpds-7913	196	18	prins	prins	PROPN
ijpds-7913	196	19	m	m	PROPN
ijpds-7913	196	20	,	,	PUNCT
ijpds-7913	196	21	nijsten	nijsten	NOUN
ijpds-7913	196	22	m	m	PROPN
ijpds-7913	196	23	,	,	PUNCT
ijpds-7913	196	24	povoa	povoa	NOUN
ijpds-7913	196	25	p	p	X
ijpds-7913	196	26	,	,	PUNCT
ijpds-7913	196	27	morris	morris	PROPN
ijpds-7913	196	28	ac	ac	PROPN
ijpds-7913	196	29	,	,	PUNCT
ijpds-7913	196	30	bracht	bracht	PROPN
ijpds-7913	196	31	h.	h.	PROPN
ijpds-7913	196	32	antimicrobial	antimicrobial	ADJ
ijpds-7913	196	33	stewardship	stewardship	NOUN
ijpds-7913	196	34	,	,	PUNCT
ijpds-7913	196	35	therapeutic	therapeutic	ADJ
ijpds-7913	196	36	drug	drug	NOUN
ijpds-7913	196	37	monitoring	monitoring	NOUN
ijpds-7913	196	38	and	and	CCONJ
ijpds-7913	196	39	infection	infection	NOUN
ijpds-7913	196	40	management	management	NOUN
ijpds-7913	196	41	in	in	ADP
ijpds-7913	196	42	the	the	DET
ijpds-7913	196	43	icu	icu	NOUN
ijpds-7913	196	44	:	:	PUNCT
ijpds-7913	196	45	results	result	NOUN
ijpds-7913	196	46	from	from	ADP
ijpds-7913	196	47	the	the	DET
ijpds-7913	196	48	international	international	ADJ
ijpds-7913	196	49	ateamicu	ateamicu	NOUN
ijpds-7913	196	50	survey	survey	NOUN
ijpds-7913	196	51	.	.	PUNCT
ijpds-7913	197	1	ann	ann	PROPN
ijpds-7913	197	2	intensive	intensive	ADJ
ijpds-7913	197	3	care	care	NOUN
ijpds-7913	197	4	.	.	PUNCT
ijpds-7913	198	1	2021	2021	NUM
ijpds-7913	198	2	aug	aug	PROPN
ijpds-7913	198	3	26;11(1):131	26;11(1):131	NUM
ijpds-7913	198	4	.	.	PUNCT
ijpds-7913	198	5	21	21	NUM
ijpds-7913	198	6	.	.	PUNCT
ijpds-7913	199	1	jacob	jacob	PROPN
ijpds-7913	199	2	s	s	PROPN
ijpds-7913	199	3	,	,	PUNCT
ijpds-7913	199	4	nair	nair	PROPN
ijpds-7913	199	5	ab	ab	PROPN
ijpds-7913	199	6	.	.	PUNCT
ijpds-7913	200	1	an	an	DET
ijpds-7913	200	2	updated	update	VERB
ijpds-7913	200	3	overview	overview	NOUN
ijpds-7913	200	4	on	on	ADP
ijpds-7913	200	5	therapeutic	therapeutic	ADJ
ijpds-7913	200	6	drug	drug	NOUN
ijpds-7913	200	7	monitoring	monitoring	NOUN
ijpds-7913	200	8	of	of	ADP
ijpds-7913	200	9	recent	recent	ADJ
ijpds-7913	200	10	antiepileptic	antiepileptic	ADJ
ijpds-7913	200	11	drugs	drug	NOUN
ijpds-7913	200	12	.	.	PUNCT
ijpds-7913	201	1	drugs	drug	NOUN
ijpds-7913	201	2	r	r	PROPN
ijpds-7913	201	3	d.	d.	PROPN
ijpds-7913	201	4	2016	2016	NUM
ijpds-7913	201	5	dec;16(4):303	dec;16(4):303	PROPN
ijpds-7913	201	6	-	-	PUNCT
ijpds-7913	201	7	316	316	NUM
ijpds-7913	201	8	.	.	PUNCT
ijpds-7913	201	9	22	22	NUM
ijpds-7913	201	10	.	.	PUNCT
ijpds-7913	202	1	lee	lee	PROPN
ijpds-7913	202	2	h	h	PROPN
ijpds-7913	202	3	,	,	PUNCT
ijpds-7913	202	4	myoung	myoung	VERB
ijpds-7913	202	5	h	h	PROPN
ijpds-7913	202	6	,	,	PUNCT
ijpds-7913	203	1	kim	kim	PROPN
ijpds-7913	203	2	sm	sm	PROPN
ijpds-7913	203	3	.	.	PROPN
ijpds-7913	204	1	review	review	NOUN
ijpds-7913	204	2	of	of	ADP
ijpds-7913	204	3	two	two	NUM
ijpds-7913	204	4	immunosuppressants	immunosuppressant	NOUN
ijpds-7913	204	5	:	:	PUNCT
ijpds-7913	204	6	tacrolimus	tacrolimus	NOUN
ijpds-7913	204	7	and	and	CCONJ
ijpds-7913	204	8	cyclosporine	cyclosporine	NOUN
ijpds-7913	204	9	.	.	PUNCT
ijpds-7913	205	1	j	j	PROPN
ijpds-7913	205	2	korean	korean	PROPN
ijpds-7913	205	3	assoc	assoc	PROPN
ijpds-7913	205	4	oral	oral	ADJ
ijpds-7913	205	5	maxillofac	maxillofac	NOUN
ijpds-7913	205	6	surg	surg	NOUN
ijpds-7913	205	7	.	.	PUNCT
ijpds-7913	206	1	2023	2023	NUM
ijpds-7913	206	2	dec	dec	PROPN
ijpds-7913	206	3	31;49(6):311	31;49(6):311	NUM
ijpds-7913	206	4	-	-	SYM
ijpds-7913	206	5	323	323	NUM
ijpds-7913	206	6	.	.	PUNCT
ijpds-7913	207	1	23	23	NUM
ijpds-7913	207	2	.	.	PUNCT
ijpds-7913	208	1	kaye	kaye	PROPN
ijpds-7913	208	2	ad	ad	PROPN
ijpds-7913	208	3	,	,	PUNCT
ijpds-7913	208	4	shah	shah	PROPN
ijpds-7913	208	5	ss	ss	PROPN
ijpds-7913	208	6	,	,	PUNCT
ijpds-7913	208	7	johnson	johnson	PROPN
ijpds-7913	208	8	cd	cd	PROPN
ijpds-7913	208	9	,	,	PUNCT
ijpds-7913	208	10	de	de	X
ijpds-7913	208	11	witt	witt	PROPN
ijpds-7913	208	12	as	as	ADP
ijpds-7913	208	13	,	,	PUNCT
ijpds-7913	208	14	thomassen	thomassen	NOUN
ijpds-7913	208	15	as	as	ADP
ijpds-7913	208	16	,	,	PUNCT
ijpds-7913	208	17	daniel	daniel	PROPN
ijpds-7913	208	18	cp	cp	PROPN
ijpds-7913	208	19	,	,	PUNCT
ijpds-7913	208	20	ahmadzadeh	ahmadzadeh	PROPN
ijpds-7913	208	21	s	s	PROPN
ijpds-7913	208	22	,	,	PUNCT
ijpds-7913	208	23	tirumala	tirumala	PROPN
ijpds-7913	208	24	s	s	PART
ijpds-7913	208	25	,	,	PUNCT
ijpds-7913	208	26	bembenick	bembenick	PROPN
ijpds-7913	208	27	kn	kn	PROPN
ijpds-7913	208	28	,	,	PUNCT
ijpds-7913	208	29	kaye	kaye	PROPN
ijpds-7913	208	30	am	am	PROPN
ijpds-7913	208	31	,	,	PUNCT
ijpds-7913	208	32	shekoohi	shekoohi	PROPN
ijpds-7913	208	33	s.	s.	PROPN
ijpds-7913	208	34	tacrolimusand	tacrolimusand	VERB
ijpds-7913	208	35	mycophenolate	mycophenolate	ADV
ijpds-7913	208	36	-	-	PUNCT
ijpds-7913	208	37	mediated	mediate	VERB
ijpds-7913	208	38	toxicity	toxicity	NOUN
ijpds-7913	208	39	:	:	PUNCT
ijpds-7913	208	40	clinical	clinical	ADJ
ijpds-7913	208	41	considerations	consideration	NOUN
ijpds-7913	208	42	and	and	CCONJ
ijpds-7913	208	43	options	option	NOUN
ijpds-7913	208	44	in	in	ADP
ijpds-7913	208	45	management	management	NOUN
ijpds-7913	208	46	of	of	ADP
ijpds-7913	208	47	post	post	ADJ
ijpds-7913	208	48	-	-	ADJ
ijpds-7913	208	49	transplant	transplant	ADJ
ijpds-7913	208	50	patients	patient	NOUN
ijpds-7913	208	51	.	.	PUNCT
ijpds-7913	209	1	curr	curr	PROPN
ijpds-7913	209	2	issues	issue	NOUN
ijpds-7913	209	3	mol	mol	ADP
ijpds-7913	209	4	biol	biol	PROPN
ijpds-7913	209	5	.	.	PUNCT
ijpds-7913	210	1	2024	2024	NUM
ijpds-7913	210	2	dec	dec	PROPN
ijpds-7913	210	3	24;47(1):2	24;47(1):2	NUM
ijpds-7913	210	4	.	.	PROPN
ijpds-7913	210	5	24	24	NUM
ijpds-7913	210	6	.	.	PUNCT
ijpds-7913	210	7	mohammadpour	mohammadpour	PROPN
ijpds-7913	210	8	n	n	NOUN
ijpds-7913	210	9	,	,	PUNCT
ijpds-7913	210	10	elyasi	elyasi	NOUN
ijpds-7913	210	11	s	s	PROPN
ijpds-7913	210	12	,	,	PUNCT
ijpds-7913	210	13	vahdati	vahdati	NOUN
ijpds-7913	210	14	n	n	CCONJ
ijpds-7913	210	15	,	,	PUNCT
ijpds-7913	210	16	mohammadpour	mohammadpour	NOUN
ijpds-7913	210	17	ah	ah	INTJ
ijpds-7913	210	18	,	,	PUNCT
ijpds-7913	210	19	shamsara	shamsara	PROPN
ijpds-7913	210	20	j.	j.	PROPN
ijpds-7913	210	21	a	a	DET
ijpds-7913	210	22	review	review	NOUN
ijpds-7913	210	23	on	on	ADP
ijpds-7913	210	24	therapeutic	therapeutic	ADJ
ijpds-7913	210	25	drug	drug	NOUN
ijpds-7913	210	26	monitoring	monitoring	NOUN
ijpds-7913	210	27	of	of	ADP
ijpds-7913	210	28	immunosuppressant	immunosuppressant	ADJ
ijpds-7913	210	29	drugs	drug	NOUN
ijpds-7913	210	30	.	.	PUNCT
ijpds-7913	211	1	iran	iran	PROPN
ijpds-7913	211	2	j	j	PROPN
ijpds-7913	211	3	basic	basic	ADJ
ijpds-7913	211	4	med	med	PROPN
ijpds-7913	211	5	sci	sci	PROPN
ijpds-7913	211	6	.	.	PROPN
ijpds-7913	211	7	2011	2011	NUM
ijpds-7913	211	8	nov;14(6):485	nov;14(6):485	NOUN
ijpds-7913	211	9	-	-	SYM
ijpds-7913	211	10	98	98	NUM
ijpds-7913	211	11	.	.	PUNCT
ijpds-7913	212	1	25	25	NUM
ijpds-7913	212	2	.	.	PUNCT
ijpds-7913	212	3	altman	altman	PROPN
ijpds-7913	212	4	ad	ad	NOUN
ijpds-7913	212	5	,	,	PUNCT
ijpds-7913	212	6	helpman	helpman	NOUN
ijpds-7913	212	7	l	l	PROPN
ijpds-7913	212	8	,	,	PUNCT
ijpds-7913	212	9	mcgee	mcgee	PROPN
ijpds-7913	212	10	j	j	PROPN
ijpds-7913	212	11	,	,	PUNCT
ijpds-7913	212	12	samouëlian	samouëlian	PROPN
ijpds-7913	212	13	v	v	PROPN
ijpds-7913	212	14	,	,	PUNCT
ijpds-7913	212	15	auclair	auclair	PROPN
ijpds-7913	212	16	mh	mh	PROPN
ijpds-7913	212	17	,	,	PUNCT
ijpds-7913	212	18	brar	brar	PROPN
ijpds-7913	212	19	h	h	PROPN
ijpds-7913	212	20	,	,	PUNCT
ijpds-7913	212	21	nelson	nelson	PROPN
ijpds-7913	212	22	gs	gs	PROPN
ijpds-7913	212	23	;	;	PUNCT
ijpds-7913	212	24	society	society	NOUN
ijpds-7913	212	25	of	of	ADP
ijpds-7913	212	26	gynecologic	gynecologic	ADJ
ijpds-7913	212	27	oncology	oncology	NOUN
ijpds-7913	212	28	of	of	ADP
ijpds-7913	212	29	agrawal	agrawal	PROPN
ijpds-7913	212	30	therapeutic	therapeutic	ADJ
ijpds-7913	212	31	drug	drug	NOUN
ijpds-7913	212	32	monitoring	monitoring	NOUN
ijpds-7913	212	33	in	in	ADP
ijpds-7913	212	34	critical	critical	ADJ
ijpds-7913	212	35	care	care	NOUN
ijpds-7913	212	36	and	and	CCONJ
ijpds-7913	212	37	transplants	transplant	NOUN
ijpds-7913	212	38	online	online	ADJ
ijpds-7913	212	39	first	first	PROPN
ijpds-7913	212	40	indian	indian	PROPN
ijpds-7913	212	41	j	j	PROPN
ijpds-7913	212	42	pharm	pharm	PROPN
ijpds-7913	212	43	drug	drug	PROPN
ijpds-7913	212	44	studies	study	NOUN
ijpds-7913	212	45	|	|	ADV
ijpds-7913	212	46	5	5	NUM
ijpds-7913	212	47	canada	canada	PROPN
ijpds-7913	212	48	’s	’s	PART
ijpds-7913	212	49	communities	community	NOUN
ijpds-7913	212	50	of	of	ADP
ijpds-7913	212	51	practice	practice	NOUN
ijpds-7913	212	52	in	in	ADP
ijpds-7913	212	53	eras	era	NOUN
ijpds-7913	212	54	and	and	CCONJ
ijpds-7913	212	55	venous	venous	ADJ
ijpds-7913	212	56	thromboembolism	thromboembolism	NOUN
ijpds-7913	212	57	.	.	PUNCT
ijpds-7913	213	1	enhanced	enhance	VERB
ijpds-7913	213	2	recovery	recovery	NOUN
ijpds-7913	213	3	after	after	ADP
ijpds-7913	213	4	surgery	surgery	NOUN
ijpds-7913	213	5	:	:	PUNCT
ijpds-7913	213	6	implementing	implement	VERB
ijpds-7913	213	7	a	a	DET
ijpds-7913	213	8	new	new	ADJ
ijpds-7913	213	9	standard	standard	NOUN
ijpds-7913	213	10	of	of	ADP
ijpds-7913	213	11	surgical	surgical	ADJ
ijpds-7913	213	12	care	care	NOUN
ijpds-7913	213	13	.	.	PUNCT
ijpds-7913	214	1	cmaj	cmaj	PROPN
ijpds-7913	214	2	.	.	PROPN
ijpds-7913	214	3	2019	2019	NUM
ijpds-7913	214	4	apr	apr	NOUN
ijpds-7913	214	5	29;191(17):e469	29;191(17):e469	NOUN
ijpds-7913	214	6	-	-	SYM
ijpds-7913	214	7	e475	e475	PROPN
ijpds-7913	214	8	.	.	PROPN
ijpds-7913	215	1	26	26	NUM
ijpds-7913	215	2	.	.	PUNCT
ijpds-7913	216	1	van	van	PROPN
ijpds-7913	216	2	gelder	gelder	PROPN
ijpds-7913	216	3	t	t	PROPN
ijpds-7913	216	4	,	,	PUNCT
ijpds-7913	216	5	gelinck	gelinck	NOUN
ijpds-7913	216	6	a	a	NOUN
ijpds-7913	216	7	,	,	PUNCT
ijpds-7913	216	8	meziyerh	meziyerh	NOUN
ijpds-7913	216	9	s	s	PART
ijpds-7913	216	10	,	,	PUNCT
ijpds-7913	216	11	de	de	PROPN
ijpds-7913	216	12	vries	vries	PROPN
ijpds-7913	216	13	apj	apj	PROPN
ijpds-7913	216	14	,	,	PUNCT
ijpds-7913	216	15	moes	moe	NOUN
ijpds-7913	216	16	djar	djar	NOUN
ijpds-7913	216	17	.	.	PUNCT
ijpds-7913	217	1	therapeutic	therapeutic	ADJ
ijpds-7913	217	2	drug	drug	NOUN
ijpds-7913	217	3	monitoring	monitoring	NOUN
ijpds-7913	217	4	of	of	ADP
ijpds-7913	217	5	tacrolimus	tacrolimus	NOUN
ijpds-7913	217	6	after	after	ADP
ijpds-7913	217	7	kidney	kidney	NOUN
ijpds-7913	217	8	transplantation	transplantation	NOUN
ijpds-7913	217	9	:	:	PUNCT
ijpds-7913	217	10	trough	trough	NOUN
ijpds-7913	217	11	concentration	concentration	NOUN
ijpds-7913	217	12	or	or	CCONJ
ijpds-7913	217	13	area	area	NOUN
ijpds-7913	217	14	under	under	ADP
ijpds-7913	217	15	curve	curve	NOUN
ijpds-7913	217	16	-	-	PUNCT
ijpds-7913	217	17	based	base	VERB
ijpds-7913	217	18	monitoring	monitoring	NOUN
ijpds-7913	217	19	?	?	PUNCT
ijpds-7913	218	1	br	br	PROPN
ijpds-7913	219	1	j	j	PROPN
ijpds-7913	219	2	clin	clin	PROPN
ijpds-7913	219	3	pharmacol	pharmacol	PROPN
ijpds-7913	219	4	.	.	PUNCT
ijpds-7913	220	1	2025	2025	NUM
ijpds-7913	220	2	jun;91(6):1600	jun;91(6):1600	PROPN
ijpds-7913	220	3	-	-	PUNCT
ijpds-7913	220	4	1606	1606	NUM
ijpds-7913	220	5	.	.	PUNCT
ijpds-7913	221	1	27	27	NUM
ijpds-7913	221	2	.	.	PUNCT
ijpds-7913	221	3	nobakht	nobakht	PROPN
ijpds-7913	221	4	e	e	NOUN
ijpds-7913	221	5	,	,	PUNCT
ijpds-7913	221	6	jagadeesan	jagadeesan	PROPN
ijpds-7913	221	7	m	m	PROPN
ijpds-7913	221	8	,	,	PUNCT
ijpds-7913	221	9	paul	paul	PROPN
ijpds-7913	221	10	r	r	PROPN
ijpds-7913	221	11	,	,	PUNCT
ijpds-7913	221	12	bromberg	bromberg	PROPN
ijpds-7913	221	13	j	j	PROPN
ijpds-7913	221	14	,	,	PUNCT
ijpds-7913	221	15	dadgar	dadgar	PROPN
ijpds-7913	221	16	s.	s.	PROPN
ijpds-7913	221	17	precision	precision	PROPN
ijpds-7913	221	18	medicine	medicine	NOUN
ijpds-7913	221	19	in	in	ADP
ijpds-7913	221	20	kidney	kidney	NOUN
ijpds-7913	221	21	transplantation	transplantation	NOUN
ijpds-7913	221	22	:	:	PUNCT
ijpds-7913	221	23	just	just	ADV
ijpds-7913	221	24	hype	hype	NOUN
ijpds-7913	221	25	or	or	CCONJ
ijpds-7913	221	26	a	a	DET
ijpds-7913	221	27	realistic	realistic	ADJ
ijpds-7913	221	28	hope	hope	NOUN
ijpds-7913	221	29	?	?	PUNCT
ijpds-7913	222	1	transplant	transplant	NOUN
ijpds-7913	222	2	direct	direct	ADJ
ijpds-7913	222	3	.	.	PUNCT
ijpds-7913	223	1	2021	2021	NUM
ijpds-7913	223	2	jan	jan	PROPN
ijpds-7913	223	3	7;7(2):e650	7;7(2):e650	PROPN
ijpds-7913	223	4	.	.	PUNCT
ijpds-7913	224	1	28	28	NUM
ijpds-7913	224	2	.	.	PUNCT
ijpds-7913	225	1	abdelmessih	abdelmessih	PROPN
ijpds-7913	225	2	e	e	PROPN
ijpds-7913	225	3	,	,	PUNCT
ijpds-7913	225	4	patel	patel	PROPN
ijpds-7913	225	5	n	n	CCONJ
ijpds-7913	225	6	,	,	PUNCT
ijpds-7913	225	7	vekaria	vekaria	PROPN
ijpds-7913	225	8	j	j	PROPN
ijpds-7913	225	9	,	,	PUNCT
ijpds-7913	225	10	crovetto	crovetto	ADJ
ijpds-7913	225	11	b	b	PROPN
ijpds-7913	225	12	,	,	PUNCT
ijpds-7913	225	13	sanfilippo	sanfilippo	NOUN
ijpds-7913	225	14	s	s	PROPN
ijpds-7913	225	15	,	,	PUNCT
ijpds-7913	225	16	adams	adams	PROPN
ijpds-7913	225	17	c	c	PROPN
ijpds-7913	225	18	,	,	PUNCT
ijpds-7913	225	19	brunetti	brunetti	PROPN
ijpds-7913	225	20	l.	l.	PROPN
ijpds-7913	225	21	vancomycin	vancomycin	PROPN
ijpds-7913	225	22	area	area	PROPN
ijpds-7913	225	23	under	under	ADP
ijpds-7913	225	24	the	the	DET
ijpds-7913	225	25	curve	curve	NOUN
ijpds-7913	225	26	versus	versus	ADP
ijpds-7913	225	27	trough	trough	NOUN
ijpds-7913	225	28	only	only	ADV
ijpds-7913	225	29	guided	guide	VERB
ijpds-7913	225	30	dosing	dosing	NOUN
ijpds-7913	225	31	and	and	CCONJ
ijpds-7913	225	32	the	the	DET
ijpds-7913	225	33	risk	risk	NOUN
ijpds-7913	225	34	of	of	ADP
ijpds-7913	225	35	acute	acute	ADJ
ijpds-7913	225	36	kidney	kidney	NOUN
ijpds-7913	225	37	injury	injury	NOUN
ijpds-7913	225	38	:	:	PUNCT
ijpds-7913	225	39	systematic	systematic	ADJ
ijpds-7913	225	40	review	review	NOUN
ijpds-7913	225	41	and	and	CCONJ
ijpds-7913	225	42	meta	meta	ADJ
ijpds-7913	225	43	-	-	PUNCT
ijpds-7913	225	44	analysis	analysis	NOUN
ijpds-7913	225	45	.	.	PUNCT
ijpds-7913	226	1	pharmacotherapy	pharmacotherapy	NOUN
ijpds-7913	226	2	.	.	PUNCT
ijpds-7913	227	1	2022	2022	NUM
ijpds-7913	227	2	sep;42(9):741	sep;42(9):741	NOUN
ijpds-7913	227	3	-	-	PUNCT
ijpds-7913	227	4	753	753	NUM
ijpds-7913	227	5	.	.	PUNCT
ijpds-7913	228	1	29	29	NUM
ijpds-7913	228	2	.	.	PUNCT
ijpds-7913	228	3	kovačević	kovačević	PROPN
ijpds-7913	228	4	t	t	PROPN
ijpds-7913	228	5	,	,	PUNCT
ijpds-7913	228	6	avram	avram	PROPN
ijpds-7913	228	7	s	s	PROPN
ijpds-7913	228	8	,	,	PUNCT
ijpds-7913	228	9	milaković	milaković	PROPN
ijpds-7913	228	10	d	d	NOUN
ijpds-7913	228	11	,	,	PUNCT
ijpds-7913	228	12	špirić	špirić	PROPN
ijpds-7913	228	13	n	n	CCONJ
ijpds-7913	228	14	,	,	PUNCT
ijpds-7913	229	1	kovačević	kovačević	NOUN
ijpds-7913	229	2	p.	p.	NOUN
ijpds-7913	229	3	therapeutic	therapeutic	ADJ
ijpds-7913	229	4	monitoring	monitoring	NOUN
ijpds-7913	229	5	of	of	ADP
ijpds-7913	229	6	amikacin	amikacin	PROPN
ijpds-7913	229	7	and	and	CCONJ
ijpds-7913	229	8	gentamicin	gentamicin	VERB
ijpds-7913	229	9	in	in	ADP
ijpds-7913	229	10	critically	critically	ADV
ijpds-7913	229	11	and	and	CCONJ
ijpds-7913	229	12	noncritically	noncritically	ADV
ijpds-7913	229	13	ill	ill	ADJ
ijpds-7913	229	14	patients	patient	NOUN
ijpds-7913	229	15	.	.	PUNCT
ijpds-7913	230	1	j	j	PROPN
ijpds-7913	230	2	basic	basic	ADJ
ijpds-7913	230	3	clin	clin	PROPN
ijpds-7913	230	4	pharm	pharm	PROPN
ijpds-7913	230	5	.	.	PUNCT
ijpds-7913	231	1	2016	2016	NUM
ijpds-7913	231	2	jun;7(3):65	jun;7(3):65	NOUN
ijpds-7913	231	3	-	-	NOUN
ijpds-7913	231	4	9	9	NUM
ijpds-7913	231	5	.	.	NOUN
ijpds-7913	231	6	30	30	NUM
ijpds-7913	231	7	.	.	PUNCT
ijpds-7913	232	1	tannous	tannous	PROPN
ijpds-7913	232	2	e	e	NOUN
ijpds-7913	232	3	,	,	PUNCT
ijpds-7913	232	4	lipman	lipman	PROPN
ijpds-7913	232	5	s	s	PROPN
ijpds-7913	232	6	,	,	PUNCT
ijpds-7913	232	7	tonna	tonna	NOUN
ijpds-7913	232	8	a	a	PRON
ijpds-7913	232	9	,	,	PUNCT
ijpds-7913	232	10	hector	hector	NOUN
ijpds-7913	232	11	e	e	PROPN
ijpds-7913	232	12	,	,	PUNCT
ijpds-7913	232	13	hussein	hussein	PROPN
ijpds-7913	232	14	z	z	PROPN
ijpds-7913	232	15	,	,	PUNCT
ijpds-7913	232	16	stein	stein	PROPN
ijpds-7913	232	17	m	m	PROPN
ijpds-7913	232	18	,	,	PUNCT
ijpds-7913	232	19	reisfeld	reisfeld	VERB
ijpds-7913	232	20	s.	s.	PROPN
ijpds-7913	232	21	time	time	NOUN
ijpds-7913	232	22	above	above	ADP
ijpds-7913	232	23	the	the	DET
ijpds-7913	232	24	mic	mic	NOUN
ijpds-7913	232	25	of	of	ADP
ijpds-7913	232	26	piperacillin	piperacillin	NOUN
ijpds-7913	232	27	-	-	PUNCT
ijpds-7913	232	28	tazobactam	tazobactam	NOUN
ijpds-7913	232	29	as	as	ADP
ijpds-7913	232	30	a	a	DET
ijpds-7913	232	31	predictor	predictor	NOUN
ijpds-7913	232	32	of	of	ADP
ijpds-7913	232	33	outcome	outcome	NOUN
ijpds-7913	232	34	in	in	ADP
ijpds-7913	232	35	pseudomonas	pseudomona	NOUN
ijpds-7913	232	36	aeruginosa	aeruginosa	NOUN
ijpds-7913	232	37	bacteremia	bacteremia	NOUN
ijpds-7913	232	38	.	.	PUNCT
ijpds-7913	233	1	antimicrob	antimicrob	PROPN
ijpds-7913	233	2	agents	agents	PROPN
ijpds-7913	233	3	chemother	chemother	PROPN
ijpds-7913	233	4	.	.	PUNCT
ijpds-7913	234	1	2020	2020	NUM
ijpds-7913	234	2	jul	jul	PROPN
ijpds-7913	234	3	22;64(8):e02571	22;64(8):e02571	NUM
ijpds-7913	234	4	-	-	SYM
ijpds-7913	234	5	19	19	NUM
ijpds-7913	234	6	.	.	PUNCT
ijpds-7913	234	7	31	31	NUM
ijpds-7913	234	8	.	.	PUNCT
ijpds-7913	235	1	luo	luo	PROPN
ijpds-7913	235	2	j	j	PROPN
ijpds-7913	235	3	,	,	PUNCT
ijpds-7913	235	4	liu	liu	PROPN
ijpds-7913	235	5	j	j	PROPN
ijpds-7913	235	6	,	,	PUNCT
ijpds-7913	235	7	lin	lin	PROPN
ijpds-7913	235	8	h	h	PROPN
ijpds-7913	235	9	,	,	PUNCT
ijpds-7913	235	10	yang	yang	PROPN
ijpds-7913	235	11	y	y	PROPN
ijpds-7913	235	12	,	,	PUNCT
ijpds-7913	235	13	chen	chen	PROPN
ijpds-7913	235	14	c	c	PROPN
ijpds-7913	235	15	,	,	PUNCT
ijpds-7913	235	16	chen	chen	PROPN
ijpds-7913	235	17	j	j	PROPN
ijpds-7913	235	18	,	,	PUNCT
ijpds-7913	235	19	zhong	zhong	PROPN
ijpds-7913	235	20	h	h	PROPN
ijpds-7913	235	21	,	,	PUNCT
ijpds-7913	235	22	zhang	zhang	PROPN
ijpds-7913	235	23	s.	s.	PROPN
ijpds-7913	235	24	optimization	optimization	PROPN
ijpds-7913	235	25	of	of	ADP
ijpds-7913	235	26	meropenem	meropenem	PROPN
ijpds-7913	235	27	dosing	dose	VERB
ijpds-7913	235	28	regimens	regimen	NOUN
ijpds-7913	235	29	in	in	ADP
ijpds-7913	235	30	critically	critically	ADV
ijpds-7913	235	31	ill	ill	ADJ
ijpds-7913	235	32	patients	patient	NOUN
ijpds-7913	235	33	with	with	ADP
ijpds-7913	235	34	augmented	augment	VERB
ijpds-7913	235	35	renal	renal	ADJ
ijpds-7913	235	36	clearance	clearance	NOUN
ijpds-7913	235	37	.	.	PUNCT
ijpds-7913	236	1	front	front	ADJ
ijpds-7913	236	2	med	med	PROPN
ijpds-7913	236	3	(	(	PUNCT
ijpds-7913	236	4	lausanne	lausanne	PROPN
ijpds-7913	236	5	)	)	PUNCT
ijpds-7913	236	6	.	.	PUNCT
ijpds-7913	237	1	2025	2025	NUM
ijpds-7913	237	2	may	may	AUX
ijpds-7913	237	3	9;12:1550053	9;12:1550053	VERB
ijpds-7913	237	4	.	.	PUNCT
ijpds-7913	238	1	32	32	NUM
ijpds-7913	238	2	.	.	PUNCT
ijpds-7913	239	1	bilal	bilal	PROPN
ijpds-7913	239	2	m	m	PROPN
ijpds-7913	239	3	,	,	PUNCT
ijpds-7913	239	4	zoller	zoller	PROPN
ijpds-7913	239	5	m	m	PROPN
ijpds-7913	239	6	,	,	PUNCT
ijpds-7913	239	7	fuhr	fuhr	PROPN
ijpds-7913	239	8	u	u	PROPN
ijpds-7913	239	9	,	,	PUNCT
ijpds-7913	239	10	jaehde	jaehde	PROPN
ijpds-7913	239	11	u	u	PROPN
ijpds-7913	239	12	,	,	PUNCT
ijpds-7913	239	13	ullah	ullah	PROPN
ijpds-7913	239	14	s	s	PROPN
ijpds-7913	239	15	,	,	PUNCT
ijpds-7913	239	16	liebchen	liebchen	ADV
ijpds-7913	239	17	u	u	NOUN
ijpds-7913	239	18	,	,	PUNCT
ijpds-7913	239	19	büsker	büsker	NOUN
ijpds-7913	239	20	s	s	NOUN
ijpds-7913	239	21	,	,	PUNCT
ijpds-7913	239	22	zander	zander	PROPN
ijpds-7913	239	23	j	j	PROPN
ijpds-7913	239	24	,	,	PUNCT
ijpds-7913	239	25	babouee	babouee	PROPN
ijpds-7913	239	26	flury	flury	PROPN
ijpds-7913	239	27	b	b	PROPN
ijpds-7913	239	28	,	,	PUNCT
ijpds-7913	239	29	taubert	taubert	PROPN
ijpds-7913	239	30	m.	m.	PROPN
ijpds-7913	239	31	cefepime	cefepime	PROPN
ijpds-7913	239	32	population	population	NOUN
ijpds-7913	239	33	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	239	34	,	,	PUNCT
ijpds-7913	239	35	antibacterial	antibacterial	ADJ
ijpds-7913	239	36	target	target	NOUN
ijpds-7913	239	37	attainment	attainment	NOUN
ijpds-7913	239	38	,	,	PUNCT
ijpds-7913	239	39	and	and	CCONJ
ijpds-7913	239	40	estimated	estimate	VERB
ijpds-7913	239	41	probability	probability	NOUN
ijpds-7913	239	42	of	of	ADP
ijpds-7913	239	43	neurotoxicity	neurotoxicity	NOUN
ijpds-7913	239	44	in	in	ADP
ijpds-7913	239	45	critically	critically	ADV
ijpds-7913	239	46	ill	ill	ADJ
ijpds-7913	239	47	patients	patient	NOUN
ijpds-7913	239	48	.	.	PUNCT
ijpds-7913	240	1	antimicrob	antimicrob	PROPN
ijpds-7913	240	2	agents	agents	PROPN
ijpds-7913	240	3	chemother	chemother	PROPN
ijpds-7913	240	4	.	.	PUNCT
ijpds-7913	241	1	2023	2023	NUM
ijpds-7913	241	2	jul	jul	PROPN
ijpds-7913	241	3	18;67(7):e0030923	18;67(7):e0030923	NUM
ijpds-7913	241	4	.	.	PUNCT
ijpds-7913	242	1	33	33	NUM
ijpds-7913	242	2	.	.	PUNCT
ijpds-7913	243	1	alsultan	alsultan	PROPN
ijpds-7913	243	2	a.	a.	NOUN
ijpds-7913	243	3	determining	determine	VERB
ijpds-7913	243	4	therapeutic	therapeutic	ADJ
ijpds-7913	243	5	trough	trough	NOUN
ijpds-7913	243	6	ranges	range	NOUN
ijpds-7913	243	7	for	for	ADP
ijpds-7913	243	8	linezolid	linezolid	NOUN
ijpds-7913	243	9	.	.	PUNCT
ijpds-7913	244	1	saudi	saudi	ADJ
ijpds-7913	244	2	pharm	pharm	PROPN
ijpds-7913	244	3	j.	j.	PROPN
ijpds-7913	244	4	2019	2019	NUM
ijpds-7913	244	5	dec;27(8):1061	dec;27(8):1061	PROPN
ijpds-7913	244	6	-	-	PUNCT
ijpds-7913	244	7	1063	1063	NUM
ijpds-7913	244	8	.	.	PUNCT
ijpds-7913	245	1	34	34	NUM
ijpds-7913	245	2	.	.	PUNCT
ijpds-7913	246	1	jin	jin	PROPN
ijpds-7913	246	2	h	h	PROPN
ijpds-7913	246	3	,	,	PUNCT
ijpds-7913	246	4	wang	wang	PROPN
ijpds-7913	246	5	t	t	PROPN
ijpds-7913	246	6	,	,	PUNCT
ijpds-7913	246	7	falcione	falcione	PROPN
ijpds-7913	246	8	ba	ba	PROPN
ijpds-7913	246	9	,	,	PUNCT
ijpds-7913	246	10	olsen	olsen	NOUN
ijpds-7913	246	11	km	km	PROPN
ijpds-7913	246	12	,	,	PUNCT
ijpds-7913	246	13	chen	chen	PROPN
ijpds-7913	246	14	k	k	PROPN
ijpds-7913	246	15	,	,	PUNCT
ijpds-7913	246	16	tang	tang	PROPN
ijpds-7913	246	17	h	h	PROPN
ijpds-7913	246	18	,	,	PUNCT
ijpds-7913	246	19	hui	hui	PROPN
ijpds-7913	246	20	j	j	PROPN
ijpds-7913	246	21	,	,	PUNCT
ijpds-7913	246	22	zhai	zhai	PROPN
ijpds-7913	246	23	s.	s.	PROPN
ijpds-7913	246	24	trough	trough	PROPN
ijpds-7913	246	25	concentration	concentration	NOUN
ijpds-7913	246	26	of	of	ADP
ijpds-7913	246	27	voriconazole	voriconazole	NOUN
ijpds-7913	246	28	and	and	CCONJ
ijpds-7913	246	29	its	its	PRON
ijpds-7913	246	30	relationship	relationship	NOUN
ijpds-7913	246	31	with	with	ADP
ijpds-7913	246	32	efficacy	efficacy	NOUN
ijpds-7913	246	33	and	and	CCONJ
ijpds-7913	246	34	safety	safety	NOUN
ijpds-7913	246	35	:	:	PUNCT
ijpds-7913	246	36	a	a	DET
ijpds-7913	246	37	systematic	systematic	ADJ
ijpds-7913	246	38	review	review	NOUN
ijpds-7913	246	39	and	and	CCONJ
ijpds-7913	246	40	meta	meta	ADJ
ijpds-7913	246	41	-	-	PUNCT
ijpds-7913	246	42	analysis	analysis	NOUN
ijpds-7913	246	43	.	.	PUNCT
ijpds-7913	247	1	j	j	PROPN
ijpds-7913	247	2	antimicrob	antimicrob	PROPN
ijpds-7913	247	3	chemother	chemother	PROPN
ijpds-7913	247	4	.	.	PUNCT
ijpds-7913	248	1	2016	2016	NUM
ijpds-7913	249	1	jul;71(7):177285	jul;71(7):177285	PROPN
ijpds-7913	249	2	.	.	PROPN
ijpds-7913	249	3	35	35	NUM
ijpds-7913	249	4	.	.	PUNCT
ijpds-7913	250	1	dekkers	dekker	NOUN
ijpds-7913	250	2	bgj	bgj	NOUN
ijpds-7913	250	3	,	,	PUNCT
ijpds-7913	250	4	bakker	bakker	PROPN
ijpds-7913	250	5	m	m	PROPN
ijpds-7913	250	6	,	,	PUNCT
ijpds-7913	250	7	van	van	PROPN
ijpds-7913	250	8	der	der	PROPN
ijpds-7913	250	9	elst	elst	PROPN
ijpds-7913	250	10	kcm	kcm	PROPN
ijpds-7913	250	11	,	,	PUNCT
ijpds-7913	250	12	sturkenboom	sturkenboom	PROPN
ijpds-7913	250	13	mgg	mgg	PROPN
ijpds-7913	250	14	,	,	PUNCT
ijpds-7913	250	15	veringa	veringa	ADV
ijpds-7913	250	16	a	a	PRON
ijpds-7913	250	17	,	,	PUNCT
ijpds-7913	250	18	span	span	NOUN
ijpds-7913	250	19	lfr	lfr	PROPN
ijpds-7913	250	20	,	,	PUNCT
ijpds-7913	250	21	alffenaar	alffenaar	PROPN
ijpds-7913	250	22	jc	jc	PROPN
ijpds-7913	250	23	.	.	PUNCT
ijpds-7913	251	1	therapeutic	therapeutic	ADJ
ijpds-7913	251	2	drug	drug	NOUN
ijpds-7913	251	3	monitoring	monitoring	NOUN
ijpds-7913	251	4	of	of	ADP
ijpds-7913	251	5	posaconazole	posaconazole	NOUN
ijpds-7913	251	6	:	:	PUNCT
ijpds-7913	251	7	an	an	DET
ijpds-7913	251	8	update	update	NOUN
ijpds-7913	251	9	.	.	PUNCT
ijpds-7913	252	1	curr	curr	PROPN
ijpds-7913	252	2	fungal	fungal	PROPN
ijpds-7913	252	3	infect	infect	PROPN
ijpds-7913	252	4	rep	rep	PROPN
ijpds-7913	252	5	.	.	PROPN
ijpds-7913	252	6	2016;10:51	2016;10:51	NUM
ijpds-7913	252	7	-	-	SYM
ijpds-7913	252	8	61	61	NUM
ijpds-7913	252	9	.	.	PUNCT
ijpds-7913	252	10	36	36	NUM
ijpds-7913	252	11	.	.	PUNCT
ijpds-7913	253	1	kunka	kunka	PROPN
ijpds-7913	253	2	me	i	PRON
ijpds-7913	253	3	,	,	PUNCT
ijpds-7913	253	4	cady	cady	PROPN
ijpds-7913	253	5	ea	ea	PROPN
ijpds-7913	253	6	,	,	PUNCT
ijpds-7913	253	7	woo	woo	VERB
ijpds-7913	253	8	hc	hc	PROPN
ijpds-7913	253	9	,	,	PUNCT
ijpds-7913	253	10	thompson	thompson	PROPN
ijpds-7913	253	11	bastin	bastin	PROPN
ijpds-7913	253	12	ml	ml	PROPN
ijpds-7913	253	13	.	.	PUNCT
ijpds-7913	254	1	flucytosine	flucytosine	VERB
ijpds-7913	254	2	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	254	3	in	in	ADP
ijpds-7913	254	4	a	a	DET
ijpds-7913	254	5	critically	critically	ADV
ijpds-7913	254	6	ill	ill	ADJ
ijpds-7913	254	7	patient	patient	NOUN
ijpds-7913	254	8	receiving	receive	VERB
ijpds-7913	254	9	continuous	continuous	ADJ
ijpds-7913	254	10	renal	renal	ADJ
ijpds-7913	254	11	replacement	replacement	NOUN
ijpds-7913	254	12	therapy	therapy	NOUN
ijpds-7913	254	13	.	.	PUNCT
ijpds-7913	255	1	case	case	NOUN
ijpds-7913	255	2	rep	rep	PROPN
ijpds-7913	255	3	crit	crit	PROPN
ijpds-7913	255	4	care	care	NOUN
ijpds-7913	255	5	.	.	PUNCT
ijpds-7913	256	1	2015;2015:927496	2015;2015:927496	NUM
ijpds-7913	256	2	.	.	PUNCT
ijpds-7913	257	1	37	37	NUM
ijpds-7913	257	2	.	.	PUNCT
ijpds-7913	258	1	hsiao	hsiao	PROPN
ijpds-7913	258	2	cy	cy	PROPN
ijpds-7913	258	3	,	,	PUNCT
ijpds-7913	258	4	ho	ho	PROPN
ijpds-7913	258	5	mc	mc	PROPN
ijpds-7913	258	6	,	,	PUNCT
ijpds-7913	258	7	ho	ho	PROPN
ijpds-7913	258	8	cm	cm	PROPN
ijpds-7913	258	9	,	,	PUNCT
ijpds-7913	258	10	wu	wu	PROPN
ijpds-7913	258	11	ym	ym	PROPN
ijpds-7913	258	12	,	,	PUNCT
ijpds-7913	258	13	lee	lee	PROPN
ijpds-7913	258	14	ph	ph	PROPN
ijpds-7913	258	15	,	,	PUNCT
ijpds-7913	258	16	hu	hu	PROPN
ijpds-7913	258	17	rh	rh	PROPN
ijpds-7913	258	18	.	.	PROPN
ijpds-7913	258	19	longterm	longterm	PROPN
ijpds-7913	258	20	tacrolimus	tacrolimus	PROPN
ijpds-7913	258	21	blood	blood	NOUN
ijpds-7913	258	22	trough	trough	NOUN
ijpds-7913	258	23	level	level	NOUN
ijpds-7913	258	24	and	and	CCONJ
ijpds-7913	258	25	patient	patient	ADJ
ijpds-7913	258	26	survival	survival	NOUN
ijpds-7913	258	27	in	in	ADP
ijpds-7913	258	28	adult	adult	NOUN
ijpds-7913	258	29	liver	liver	NOUN
ijpds-7913	258	30	transplantation	transplantation	NOUN
ijpds-7913	258	31	.	.	PUNCT
ijpds-7913	259	1	j	j	PROPN
ijpds-7913	259	2	pers	per	NOUN
ijpds-7913	259	3	med	me	VERB
ijpds-7913	259	4	.	.	PUNCT
ijpds-7913	260	1	2021	2021	NUM
ijpds-7913	260	2	feb	feb	PROPN
ijpds-7913	260	3	1;11(2):90	1;11(2):90	NUM
ijpds-7913	260	4	.	.	PUNCT
ijpds-7913	261	1	38	38	NUM
ijpds-7913	261	2	.	.	PUNCT
ijpds-7913	262	1	delgado	delgado	VERB
ijpds-7913	262	2	dh	dh	PROPN
ijpds-7913	262	3	,	,	PUNCT
ijpds-7913	262	4	rao	rao	PROPN
ijpds-7913	262	5	v	v	PROPN
ijpds-7913	262	6	,	,	PUNCT
ijpds-7913	262	7	hamel	hamel	PROPN
ijpds-7913	262	8	j	j	PROPN
ijpds-7913	262	9	,	,	PUNCT
ijpds-7913	262	10	miriuka	miriuka	PROPN
ijpds-7913	262	11	s	s	PROPN
ijpds-7913	262	12	,	,	PUNCT
ijpds-7913	262	13	cusimano	cusimano	PROPN
ijpds-7913	262	14	rj	rj	PROPN
ijpds-7913	262	15	,	,	PUNCT
ijpds-7913	262	16	ross	ross	PROPN
ijpds-7913	262	17	hj	hj	PROPN
ijpds-7913	262	18	.	.	PUNCT
ijpds-7913	263	1	monitoring	monitoring	NOUN
ijpds-7913	263	2	of	of	ADP
ijpds-7913	263	3	cyclosporine	cyclosporine	ADJ
ijpds-7913	263	4	2	2	NUM
ijpds-7913	263	5	-	-	PUNCT
ijpds-7913	263	6	hour	hour	NOUN
ijpds-7913	263	7	post	post	ADJ
ijpds-7913	263	8	-	-	ADJ
ijpds-7913	263	9	dose	dose	ADJ
ijpds-7913	263	10	levels	level	NOUN
ijpds-7913	263	11	in	in	ADP
ijpds-7913	263	12	heart	heart	NOUN
ijpds-7913	263	13	transplantation	transplantation	NOUN
ijpds-7913	263	14	:	:	PUNCT
ijpds-7913	263	15	improvement	improvement	NOUN
ijpds-7913	263	16	in	in	ADP
ijpds-7913	263	17	clinical	clinical	ADJ
ijpds-7913	263	18	outcomes	outcome	NOUN
ijpds-7913	263	19	.	.	PUNCT
ijpds-7913	264	1	j	j	PROPN
ijpds-7913	264	2	heart	heart	NOUN
ijpds-7913	264	3	lung	lung	NOUN
ijpds-7913	264	4	transplant	transplant	NOUN
ijpds-7913	264	5	.	.	PUNCT
ijpds-7913	265	1	2005	2005	NUM
ijpds-7913	265	2	sep;24(9):1343	sep;24(9):1343	NOUN
ijpds-7913	265	3	-	-	PUNCT
ijpds-7913	265	4	6	6	NUM
ijpds-7913	265	5	.	.	NOUN
ijpds-7913	265	6	39	39	NUM
ijpds-7913	265	7	.	.	PUNCT
ijpds-7913	266	1	sabo	sabo	PROPN
ijpds-7913	266	2	an	an	PRON
ijpds-7913	266	3	,	,	PUNCT
ijpds-7913	266	4	jannier	janni	ADJ
ijpds-7913	266	5	s	s	PROPN
ijpds-7913	266	6	,	,	PUNCT
ijpds-7913	266	7	becker	becker	PROPN
ijpds-7913	266	8	g	g	NOUN
ijpds-7913	266	9	,	,	PUNCT
ijpds-7913	266	10	lessinger	lessinger	PROPN
ijpds-7913	266	11	jm	jm	PROPN
ijpds-7913	266	12	,	,	PUNCT
ijpds-7913	266	13	entz	entz	NOUN
ijpds-7913	266	14	-	-	PUNCT
ijpds-7913	266	15	werlé	werlé	PROPN
ijpds-7913	266	16	n	n	CCONJ
ijpds-7913	266	17	,	,	PUNCT
ijpds-7913	266	18	kemmel	kemmel	PROPN
ijpds-7913	267	1	v.	v.	ADP
ijpds-7913	267	2	sirolimus	sirolimus	PROPN
ijpds-7913	267	3	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	267	4	variability	variability	NOUN
ijpds-7913	267	5	points	point	NOUN
ijpds-7913	267	6	to	to	ADP
ijpds-7913	267	7	the	the	DET
ijpds-7913	267	8	relevance	relevance	NOUN
ijpds-7913	267	9	of	of	ADP
ijpds-7913	267	10	therapeutic	therapeutic	ADJ
ijpds-7913	267	11	drug	drug	NOUN
ijpds-7913	267	12	monitoring	monitoring	NOUN
ijpds-7913	267	13	in	in	ADP
ijpds-7913	267	14	pediatric	pediatric	ADJ
ijpds-7913	267	15	oncology	oncology	NOUN
ijpds-7913	267	16	.	.	PUNCT
ijpds-7913	268	1	pharmaceutics	pharmaceutic	NOUN
ijpds-7913	268	2	.	.	PUNCT
ijpds-7913	269	1	2021	2021	NUM
ijpds-7913	269	2	mar	mar	PROPN
ijpds-7913	269	3	30;13(4):470	30;13(4):470	NUM
ijpds-7913	269	4	.	.	PUNCT
ijpds-7913	270	1	40	40	NUM
ijpds-7913	270	2	.	.	PUNCT
ijpds-7913	271	1	ogutu	ogutu	PROPN
ijpds-7913	271	2	br	br	PROPN
ijpds-7913	271	3	,	,	PUNCT
ijpds-7913	271	4	newton	newton	PROPN
ijpds-7913	271	5	cr	cr	PROPN
ijpds-7913	271	6	,	,	PUNCT
ijpds-7913	271	7	muchohi	muchohi	PROPN
ijpds-7913	271	8	sn	sn	PROPN
ijpds-7913	271	9	,	,	PUNCT
ijpds-7913	271	10	otieno	otieno	VERB
ijpds-7913	271	11	go	go	VERB
ijpds-7913	271	12	,	,	PUNCT
ijpds-7913	271	13	edwards	edwards	PROPN
ijpds-7913	271	14	g	g	PROPN
ijpds-7913	271	15	,	,	PUNCT
ijpds-7913	271	16	watkins	watkins	PROPN
ijpds-7913	271	17	wm	wm	PROPN
ijpds-7913	271	18	,	,	PUNCT
ijpds-7913	271	19	kokwaro	kokwaro	PROPN
ijpds-7913	271	20	go	go	VERB
ijpds-7913	271	21	.	.	PUNCT
ijpds-7913	272	1	pharmacokinetics	pharmacokinetic	NOUN
ijpds-7913	272	2	and	and	CCONJ
ijpds-7913	272	3	clinical	clinical	ADJ
ijpds-7913	272	4	effects	effect	NOUN
ijpds-7913	272	5	of	of	ADP
ijpds-7913	272	6	phenytoin	phenytoin	NOUN
ijpds-7913	272	7	and	and	CCONJ
ijpds-7913	272	8	fosphenytoin	fosphenytoin	VERB
ijpds-7913	272	9	in	in	ADP
ijpds-7913	272	10	children	child	NOUN
ijpds-7913	272	11	with	with	ADP
ijpds-7913	272	12	severe	severe	ADJ
ijpds-7913	272	13	malaria	malaria	NOUN
ijpds-7913	272	14	and	and	CCONJ
ijpds-7913	272	15	status	status	NOUN
ijpds-7913	272	16	epilepticus	epilepticus	NOUN
ijpds-7913	272	17	.	.	PUNCT
ijpds-7913	273	1	br	br	PROPN
ijpds-7913	274	1	j	j	PROPN
ijpds-7913	274	2	clin	clin	PROPN
ijpds-7913	274	3	pharmacol	pharmacol	PROPN
ijpds-7913	274	4	.	.	PUNCT
ijpds-7913	275	1	2003	2003	NUM
ijpds-7913	276	1	jul;56(1):112	jul;56(1):112	PROPN
ijpds-7913	276	2	-	-	PUNCT
ijpds-7913	276	3	9	9	NUM
ijpds-7913	276	4	.	.	NOUN
ijpds-7913	276	5	41	41	NUM
ijpds-7913	276	6	.	.	PUNCT
ijpds-7913	277	1	tseng	tseng	PROPN
ijpds-7913	277	2	yj	yj	PROPN
ijpds-7913	277	3	,	,	PUNCT
ijpds-7913	277	4	huang	huang	PROPN
ijpds-7913	277	5	sy	sy	PROPN
ijpds-7913	277	6	,	,	PUNCT
ijpds-7913	277	7	kuo	kuo	PROPN
ijpds-7913	277	8	ch	ch	PROPN
ijpds-7913	277	9	,	,	PUNCT
ijpds-7913	277	10	wang	wang	PROPN
ijpds-7913	277	11	cy	cy	PROPN
ijpds-7913	277	12	,	,	PUNCT
ijpds-7913	277	13	wang	wang	PROPN
ijpds-7913	277	14	kc	kc	PROPN
ijpds-7913	277	15	,	,	PUNCT
ijpds-7913	277	16	wu	wu	PROPN
ijpds-7913	277	17	cc	cc	PROPN
ijpds-7913	277	18	.	.	PROPN
ijpds-7913	277	19	safety	safety	NOUN
ijpds-7913	277	20	range	range	NOUN
ijpds-7913	277	21	of	of	ADP
ijpds-7913	277	22	free	free	ADJ
ijpds-7913	277	23	valproic	valproic	ADJ
ijpds-7913	277	24	acid	acid	NOUN
ijpds-7913	277	25	serum	serum	NOUN
ijpds-7913	277	26	concentration	concentration	NOUN
ijpds-7913	277	27	in	in	ADP
ijpds-7913	277	28	adult	adult	NOUN
ijpds-7913	277	29	patients	patient	NOUN
ijpds-7913	277	30	.	.	PUNCT
ijpds-7913	278	1	plos	plos	PROPN
ijpds-7913	278	2	one	one	NUM
ijpds-7913	278	3	.	.	PUNCT
ijpds-7913	279	1	2020	2020	NUM
ijpds-7913	279	2	sep	sep	PROPN
ijpds-7913	279	3	2;15(9):e0238201	2;15(9):e0238201	NUM
ijpds-7913	279	4	.	.	PUNCT
ijpds-7913	280	1	42	42	NUM
ijpds-7913	280	2	.	.	PUNCT
ijpds-7913	281	1	nolen	nolen	PROPN
ijpds-7913	281	2	wa	wa	PROPN
ijpds-7913	281	3	,	,	PUNCT
ijpds-7913	281	4	jansen	jansen	PROPN
ijpds-7913	281	5	gs	gs	PROPN
ijpds-7913	281	6	,	,	PUNCT
ijpds-7913	281	7	broekman	broekman	NOUN
ijpds-7913	281	8	m.	m.	NOUN
ijpds-7913	281	9	measuring	measure	VERB
ijpds-7913	281	10	plasma	plasma	NOUN
ijpds-7913	281	11	levels	level	NOUN
ijpds-7913	281	12	of	of	ADP
ijpds-7913	281	13	carbamazepine	carbamazepine	NOUN
ijpds-7913	281	14	.	.	PUNCT
ijpds-7913	282	1	a	a	DET
ijpds-7913	282	2	pharmacokinetic	pharmacokinetic	ADJ
ijpds-7913	282	3	study	study	NOUN
ijpds-7913	282	4	in	in	ADP
ijpds-7913	282	5	patients	patient	NOUN
ijpds-7913	282	6	with	with	ADP
ijpds-7913	282	7	affective	affective	ADJ
ijpds-7913	282	8	disorders	disorder	NOUN
ijpds-7913	282	9	.	.	PUNCT
ijpds-7913	283	1	pharmacopsychiatry	pharmacopsychiatry	NOUN
ijpds-7913	283	2	.	.	PUNCT
ijpds-7913	284	1	1988	1988	NUM
ijpds-7913	285	1	sep;21(5):2524	sep;21(5):2524	PROPN
ijpds-7913	285	2	.	.	PROPN
ijpds-7913	285	3	43	43	NUM
ijpds-7913	285	4	.	.	PUNCT
ijpds-7913	286	1	goldberger	goldberger	PROPN
ijpds-7913	286	2	zd	zd	PROPN
ijpds-7913	286	3	,	,	PUNCT
ijpds-7913	286	4	goldberger	goldberger	PROPN
ijpds-7913	286	5	al	al	PROPN
ijpds-7913	286	6	.	.	PUNCT
ijpds-7913	287	1	therapeutic	therapeutic	ADJ
ijpds-7913	287	2	ranges	range	NOUN
ijpds-7913	287	3	of	of	ADP
ijpds-7913	287	4	serum	serum	NOUN
ijpds-7913	287	5	digoxin	digoxin	NOUN
ijpds-7913	287	6	concentrations	concentration	NOUN
ijpds-7913	287	7	in	in	ADP
ijpds-7913	287	8	patients	patient	NOUN
ijpds-7913	287	9	with	with	ADP
ijpds-7913	287	10	heart	heart	NOUN
ijpds-7913	287	11	failure	failure	NOUN
ijpds-7913	287	12	.	.	PUNCT
ijpds-7913	288	1	am	be	AUX
ijpds-7913	288	2	j	j	PROPN
ijpds-7913	288	3	cardiol	cardiol	NOUN
ijpds-7913	288	4	.	.	PUNCT
ijpds-7913	289	1	2012	2012	NUM
ijpds-7913	289	2	jun	jun	PROPN
ijpds-7913	289	3	15;109(12):1818	15;109(12):1818	NUM
ijpds-7913	289	4	-	-	SYM
ijpds-7913	289	5	21	21	NUM
ijpds-7913	289	6	.	.	PUNCT
ijpds-7913	290	1	how	how	SCONJ
ijpds-7913	290	2	to	to	PART
ijpds-7913	290	3	cite	cite	VERB
ijpds-7913	290	4	this	this	DET
ijpds-7913	290	5	article	article	NOUN
ijpds-7913	290	6	:	:	PUNCT
ijpds-7913	290	7	agrawal	agrawal	PROPN
ijpds-7913	290	8	r.	r.	PROPN
ijpds-7913	290	9	therapeutic	therapeutic	ADJ
ijpds-7913	290	10	drug	drug	NOUN
ijpds-7913	290	11	monitoring	monitoring	NOUN
ijpds-7913	290	12	(	(	PUNCT
ijpds-7913	290	13	tdm	tdm	NOUN
ijpds-7913	290	14	):	):	PUNCT
ijpds-7913	290	15	a	a	DET
ijpds-7913	290	16	necessity	necessity	NOUN
ijpds-7913	290	17	in	in	ADP
ijpds-7913	290	18	critical	critical	ADJ
ijpds-7913	290	19	care	care	NOUN
ijpds-7913	290	20	and	and	CCONJ
ijpds-7913	290	21	transplant	transplant	NOUN
ijpds-7913	290	22	settings	setting	NOUN
ijpds-7913	290	23	.	.	PUNCT
ijpds-7913	291	1	indian	indian	PROPN
ijpds-7913	291	2	j	j	PROPN
ijpds-7913	291	3	pharm	pharm	PROPN
ijpds-7913	291	4	drug	drug	PROPN
ijpds-7913	291	5	studies	study	NOUN
ijpds-7913	291	6	.	.	PUNCT
ijpds-7913	292	1	2025	2025	NUM
ijpds-7913	292	2	;	;	PUNCT
ijpds-7913	292	3	online	online	ADJ
ijpds-7913	292	4	first	first	ADJ
ijpds-7913	292	5	.	.	PUNCT
ijpds-7913	293	1	funding	funding	NOUN
ijpds-7913	293	2	:	:	PUNCT
ijpds-7913	293	3	none	none	NOUN
ijpds-7913	293	4	;	;	PUNCT
ijpds-7913	293	5	conflicts	conflict	NOUN
ijpds-7913	293	6	of	of	ADP
ijpds-7913	293	7	interest	interest	NOUN
ijpds-7913	293	8	:	:	PUNCT
ijpds-7913	293	9	none	none	NOUN
ijpds-7913	293	10	stated	state	VERB
ijpds-7913	293	11	i.	i.	PROPN
ijpds-7913	293	12	tdm	tdm	PROPN
ijpds-7913	293	13	in	in	ADP
ijpds-7913	293	14	critical	critical	ADJ
ijpds-7913	293	15	care	care	NOUN