id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-311144-tumtzad8	Franco-Muñoz, Carlos	Substitutions in Spike and Nucleocapsid proteins of SARS-CoV-2 circulating in South America	2020-09-17		.txt	text/plain	2829	89	40	Recombinant proteins or synthetic peptides of SARS-CoV-2 are widely explored as alternatives to be used in serological tests and therapeutics against SARS-CoV-2 and related Betacoronavirus (Du et al., 2009; Jacofsky et al., 2020) , considering that S and N proteins are the major immunogenic proteins of SARS and MERS coronavirus and the first choice for producing recombinant antigens (Yan et al., 2020) . J o u r n a l P r e -p r o o f Journal Pre-proof Furthermore, non-synonymous mutations in the S and N proteins have been reported, their implications in the potential emergence of antigenically distinct and/or more virulent strains remain to be studied, although it was reported that mutations in the receptor-binding domain (RBD) at the S protein of SARS-CoV related viruses disrupt the antigenic structure and binding activity of RBD to ACE2 (Du et al., 2009 )	cache/cord-311144-tumtzad8.txt	txt/cord-311144-tumtzad8.txt
