Microsoft Word - IJHHS IMAM 23rd ASC 2022


  
 

 S28

 
Sinonasal Lymphoma: A Rare Pathology Presenting with Common Post-Influenza Symptoms  
  
Muhamad Ariff Sobani1, Noor Shahira Mohamad Fuzi1, Intan Kartika Kamarudin1,2, Norazila Abdul 
Rahim1,2, Nik Mohd Hazleigh Nik Hussin1,2   
  
Sinonasal malignancies are uncommon and only account for 3% of head and neck cancers. Despite 
diffuse large B-cell lymphomas (DLBCL) being the most common type of non-Hodgkins lymphoma 
occurring at various extranodal sites, its occurrence as a sinonasal tumor is exceedingly rare. Early 
detection and treatment of sinonasal lymphoma, have favourable outcomes with improvements in the 
2-year and 5-year survival rates.   

We are reporting a case of primary sinonasal DLBCL in a 63-year-old lady who initially 
presented with nasal obstruction and epistaxis, both common symptoms in patients who have had a 
recent Influenza A infection. However, due to the unilaterality and progressive nature of her nasal 
obstruction, she warranted a specialist otorhinolaryngology assessment. Naso endoscopy revealed a 
unilateral nasal mass extending from the right middle meatus to the nasal floor and was friable with 
contact bleeding. These clinical findings are similarly seen in most of the various types of sinonasal 
malignancies, and diagnosis can be challenging. Pathologists rely upon immunohistochemical staining 
profiles to differentiate this highly heterogeneous group of malignancies. Histopathological 
examination confirmed the diagnosis of sinonasal lymphoma. The treatment of this rare pathological 
entity is discussed.  
  
Keywords: Sinonasal Lymphoma, Epistaxis, Unilateral Nasal Mass, Diffuse Large B-Cell Lymphoma  
 

1. Department of Otorhinolaryngology, Head and Neck Surgery, Hospital Al-Sultan 
Abdullah UiTM, Universiti Teknologi MARA, Selangor, Malaysia  
2. Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, 
Universiti Teknologi MARA, Selangor, Malaysia  

  
   

 

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Correspondence to:  

Intan Kartika Kamarudin, Senior Lecturer and Otorhinolaryngology Head and Neck Surgeon, 
Department of Otorhinolaryngology Head and Neck Surgery, Universiti Teknologi MARA, Malaysia, 
kartika@uitm.edu.my 

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DOI: http://dx.doi.org/10.31344/ijhhs.v7i70.530