ISSN 2413-6077. IJMMR 2018 Vol. 4 Issue 152 P U B L IC H E A LT H A N D E P ID E M IO L O G Y International Journal of Medicine and Medical Research 2018, volume 4, Issue 1, p. 52-59 copyright © 2018, TSMU, All Rights Reserved DOI 10.11603/IJMMR.2413-6077.2018.1.8971 EPIdEmIOLOGIc EvALUATION Of ThyROId dIsEAsEs mORBIdITy Of UKRAINIAN AdULT POPULATION fROm 2000 TO 2013 А. М. Antonenko, М. М. Korshun, O. P. Vavrinevych, S. T. Omelchuk, V.H. Bardov O. O. BOGOMOLETS NATIONAL MEDICAL UNIVERSITy, KyIV, UKRAINE Background. The diseases of thyroid gland have been attracting considerable attention in recent decades. This is partly due to the fact that thyroid gland reacts actively to geochemical state and pollution of the environment with industrial and agricultural waste products with the subsequent incidence of certain pathological processes. The objective of the research was to analyze the morbidity of adult population of Ukraine for thyroid gland diseases in the period from 2000 to 2013. Methods. The methods of empirical and theoretical research of scientific information: analysis, synthesis, induction, deduction and systematization, as well as epidemiological and statistical methods were used. Using the Microsoft Office Excel (2007) and IBM SPSS StatisticsBase v.22 program the correlation and regression analyzes were conducted. Results. From 2000 to 2013, high levels of adult population endocrinopathies, thyroid in general and diffuse goiter of varying degrees, general and primary morbidity were registered in the western and northern regions of Ukraine, low – in the central, eastern and southern regions. Statistically significant (p<0.001) positive correlation between the level of prevalence and the level of incidence of endocrine pathology, diseases of thyroid gland as a whole, as well as individual nosology was detected. Conclusions. Regional peculiarities of the levels and dynamics of changes in the incidence rates of thyroid morbidity among adult population of Ukraine can be related to the urgent environmental factors for each region. This factor requires further study to develop effective methods of prophylaxis and defense. KEY WORDS: morbidity; thyroid gland; adult population. Corresponding author: Аnna Antonenko, Hygiene and Ecology Department № 1, O. O. Bogomolets National Medical Univer- sity, 34, Peremogy avenue, Kyiv, 03680, Ukraine E-mail: antonenko1985@ukr.net Phone number: +380991466331 Introduction The diseases of thyroid gland have been attracting considerable attention in recent decades. In the structure of endocrine pathology prevalence in ukraine they are the first: on average 44 %, and in the endemic with iodine deficiency western regions – up to 70 % [1]. this is partly due to the fact that thyroid gland reacts actively to geochemical state and pollution of the environment with industrial and agricultural waste products with the subsequent occurrence of certain pathological processes [2]. In the structure of endocrinological pathology, different types of goiter are the largest share [3, 4]. Minimizing thyroid dysfunction rates is an important task for most countries of the world, since, according to the WHO publications, nearly 2 billion planet’s inhabitants are at risk for thyroid diseases, including iodine-dependent diseases [4, 5]. The objective of the research was to analyze the morbidity of adult population of Ukraine for thyroid gland diseases in the period from 2000 to 2013. Methods The object of our research was the level and the dynamics of endocrine system (Class Iv, E00-E90 according to the International Diseases Classification of the tenth Revision) and thyroid gland (E00-E07) general morbidity (prevalence1) and primary morbidity (incidence2) of adult population in 24 regions of Ukraine, the Crimea as well as Kyiv and Sevastopil cities, in the period from 2000 to 2013. The sources of information were the reports of the endocrinology Service of ukraine ̒the main indices of the activity of the endocrinology service of ukraine...̓ for the period of 8 years: 2000, 2004, 2005, 2006, 2009, 2010, 2011 and 2013 [7–14], according to which the evaluation of general endocrinology morbidity, incidence of diffuse nontoxic goiter degree i, diffuse non- 1 The term recommended by WHO. 2 The term recommended by WHO. А. М. Antonenko et al. ISSN 2413-6077. IJMMR 2018 Vol. 4 Issue 1 53 P U B L IC H E A LT H A N D E P ID E M IO L O G Y toxic goiter degree ii–iii, nodule goiter, hypothyroidism, thyrotoxicosis, thyroiditis and thyroid cancer (II class of neoplasm, C73) was carried out. The spreadsheet was developed in Microsoft office excel (2007). The methods of empirical and theoretical research of scientific information: analysis, synthesis, induction, deduction and syste- matization, as well as epidemiological and statistical methods were used. For the analysis of changes in the level of general and primary thyroid disease, the average absolute increase (AI), which charac- terizes the average annual increase rate, increase rate (AIR,%) and increase rate (IR,%), were evaluated. The estimation of the basic (relative to the level of the initial year) and the chain (relative to the level of the previous year) indices were carried out. using the Microsoft office excel (2007) and IBM SPSS StatisticsBase v.22 program corre_ lation (with Pearson correlation coefficient – r) and regression analyzes to estimate the dynamics of population morbidity over a fourteen-year period, the ranking of investigated administrative territories (AT) of Ukraine according to the levels of prevalence and in- cidence for 2000–2013 years and the rate of their increase, the identification of the re lationship between the incidence rate of individual thyroid diseases and the relationship between the levels and the rate of morbidity index increase according to the calculation of the Spearman rank correlation coefficient (rs), were conducted Results The current WHO statistics prove that the pathology of endocrine system takes the third place after cardiovascular and cancerous diseases in the structure of the overall morbidity and causes of mortality in most countries of the world and it continues to increase [1]. A similar situation is evidenced in Ukraine also, where the increase in the number of patients with various endocrinopathies in the period from 2005 to 2010 amounted to 9.85 % [14]. It has been established that in the period from 2000 to 2013, the overall endocrinology incidence (prevalence of endocrinopathies) of adult population in 16 regions of Ukraine, the Crimea, Kyiv and Sevastopil increased, as evidenced by the statistically significant coefficients of the Pearson correlation pair (r>rtabl; rtabl=0.707 at n=8, p=0.05). Regarding the primary incidence of endocrine system diseases, in the period of monitoring, a positive correlation was established only in 6 regions, another one (Cherkasy) proved a tendency to increase (r>rtabl; rtabl=0.629 at n=8, p=0.1). At the same time, the largest AIR and IR of both general and primary morbidity were observed in Zaporizhia region (IR 137.1 and 118.6 % respectively), Kyiv (113.3 and 33.8 %), Mykolaiv (102.7 and 55.8 %), Kharkiv (100.7 and 64.8 %), and Poltava (100.1 and 57.4 %) regions (respectively, 1, 2, 3, 4 and 5 rank positions for IR of general morbidity and 1, 5 , 4, 2 and 3 – IR of primary morbidity). Significant (p<0.05) decrease of the total endocrinological morbidity that correlated with the year was observed only in three regions: volyn (administrative center is lutsk), Sumy and Chernihiv. in the other (five) regions the statis- tically significant correlation between the pre- va lence of endocrine pathology and the year was not proved. Regarding the primary morbi- dity, a statistically significant inverse correlation relationship was established in 8 regions (inclu- ding volyn, Sumy and Chernihiv); in ano ther one (Kirovohrad, administrative center Kro- pyvnytskyi) and Crimea regions there was a tendency to index decrease (0.050.1). In general, between the IR of the general and IR of the primary incidence of endocrine system diseases in the period from 2000 to 2013 there was a significant positive correlation (rs=0.916; rs tabl=0.597 at n=27, p=0.001). The same correlation was found between the levels of prevalence and incidence of endocrine pathology (rs=0.841). In general, in the period from 2000 to 2013, the highest levels of both indices of endocrine disease were reported in vinnytsia region and the regions of Western ukraine: Zakarpattia (administrative center is Uzhgorod), Rivne, volyn (Table. 1). Primary morbidity was high also in Ivano-Frankivsk, Ternopil and Khmel- nitsky regions, and prevalence – in the northern regions (Kyiv, Chernihiv and Sumy regions). It should be noted that these areas have the highest incidence of diffuse goiter of varying degrees; in the northern regions of nodular goiter and thyroid cancer as well. The seven last ranked places according to both indices of endocrine system diseases inci- dence were occupied by the eastern (lu hansk), southern (Zaporizhia, Kherson), central (Poltava) regions and Sevastopil. Primary morbidity was also low in Donetsk and Odesa regions, and prevalence – in Kirovohrad and Mykolaiv. The А. М. Antonenko et al. ISSN 2413-6077. IJMMR 2018 Vol. 4 Issue 154 P U B L IC H E A LT H A N D E P ID E M IO L O G Y Ta bl e 1. R an ki n g of a dm in is tr at iv e te rr it or ie s ac co rd in g to t h e le ve ls o f th yr oi d ge n er al ( G M ) an d pr im ar y (P M ) m or bi di ty o f ad u lt p op u la ti on d u ri n g th e pe ri od o f 20 00 –2 01 3 Re gi on s Ad m in is tr at iv e te rr ito ry Ra nk s En do cr in e sy st em d is ea s- es (E SD ) D iff us e go ite r of I de gr ee (d g -І ) D iff us e go ite r of II -I II d eg re es (d g -І І+ ІІ І) N od ul ar g oi te r (N G ) Th yr oi d ca nc er (T C) H yp ot hy ro id - is m (H T) th yr ot ox ic os is (Т t) Th yr oi di tis (T D ) ЗЗ П З ЗЗ П З ЗЗ П З ЗЗ П З ЗЗ П З ЗЗ П З ЗЗ П З ЗЗ П З 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 W es te rn vo ly n 2* * 5* * 1* * 2* * 4* * 4* * 12 16 27 ’’ 25 ’’ 10 24 ’’ 17 18 25 ’’ 26 ’’ Za ka rp at tia 3* * 1* * 2* * 3* * 1* * 1* * 20 27 ’’ 25 ’’ 27 ’’ 14 13 2* * 3 ** 24 ’’ 24 ’’ Iv an o- Fr an ki vs k 8 4* * 7* * 4* * 17 17 18 23 ’’ 26 ’’ 26 ’’ 1* * 8 4* * 4 ** 22 ’’ 20 lv iv 11 12 6* * 6* * 14 16 24 ’’ 22 ’’ 17 15 16 18 8 21 ’’ 14 14 Ri vn e 5* * 2* * 4* * 1* * 2* * 2* * 14 14 23 ’’ 21 ’’ 22 ’’ 19 16 10 23 ’’ 22 ’’ Te rn op il 12 6* * 13 5* * 10 13 19 25 ’’ 22 ’’ 22 ’’ 19 21 ’’ 15 19 27 ’’ 27 ’’ Kh m el ni ts ky 9 7* * 14 10 11 8 8 12 18 20 6* * 4 * 1* * 1 ** 17 12 Ch er ni vt si 10 8 12 12 5* * 6* * 22 ’’ 19 11 24 ’’ 25 ’’ 23 ’’ 10 26 ’’ 12 18 N or th er n Zh yt om yr 15 16 11 13 9 9 7* * 13 15 12 24 ’’ 26 ’’ 13 16 19 23 ’’ Ky iv 4* * 15 3* * 11 3* * 3* * 2* * 3* * 2* * 2* * 8 10 21 ’’ 17 6* * 4* * Su m y 7* * 9 10 9 7* * 5* * 4* * 5* * 8 4* * 17 15 6* * 12 7* * 9 Ch er ni hi v 6* * 19 5* * 14 6* * 15 3* * 4* * 6* * 6* * 21 ’’ 20 7* * 13 9 10 Th e ci ty o f K yi v 16 17 21 ’’ 20 15 12 1* * 1* * 1* * 1* * 2* * 1* * 24 ’’ 7 ** 1* * 1* * Ce nt ra l vi nn yt si a 1* * 3* * 8 7* * 8 11 5* * 2* * 4* * 7* * 5* * 5* * 5* * 15 8 7, 5* * D ni pr op et ro vs k 17 18 16 16 12 10 13 8 7* * 9 4* * 2* * 9 6* * 5* * 6* * Ki ro vo hr ad 21 ’’ 13 15 15 24 ’’ 19 21 ’’ 20 19 16 26 ’’ 27 ’’ 20 27 ’’ 13 15 Po lta va 22 ’’ 24 ’’ 18 21 ’’ 19 24 ’’ 9 6* * 13 11 18 14 14 8 15 13 Ch er ka sy 13 10 20 18 13 7* * 10 10 12 10 11 12 12 2* * 21 ’’ 19 Ea st er n D on et sk 19 21 ’’ 22 ’’ 23 ’’ 21 ’’ 22 ’’ 11 9 9 13 3* * 3* * 3* * 5* * 2* * 3* * lu ha ns k 27 ’’ 26 ’’ 23 ’’ 22 ’’ 20 18 27 ’’ 21 ’’ 24 ’’ 23 ’’ 27 ’’ 25 ’’ 25 ’’ 14 26 ’’ 25 ’’ Kh ar ki v 18 14 17 17 16 14 25 ’’ 15 16 19 13 6* * 27 ’’ 24 ’’ 3* * 2* * So ut he rn Za po ri zh ia 26 ’’ 26 ’’ 24 ’’ 24 ’’ 26 ’’ 25 ’’ 16 11 10 88 23 ’’ 17 19 11 11 5* * M yk ol ai v 24 ’’ 20 19 19 22 ’’ 21 ’’ 26 ’’ 18 21 ’’ 7* * 9 26 ’’ 23 ’’ 10 11 А. М. Antonenko et al. ISSN 2413-6077. IJMMR 2018 Vol. 4 Issue 1 55 P U B L IC H E A LT H A N D E P ID E M IO L O G Y Ta bl e 2. C or re la ti on b et w ee n t h e le ve ls o f th yr oi d ge n er al ( G M ) an d pr im ar y (P M ) m or bi di ty o f ad u lt p op u la ti on o f U kr ai n e du ri n g th e pe ri od of 2 00 0– 20 13 . Sp ea rm an ’s r an k co rr el at io n co effi ci en ts ES D - G M ES D - P M d g -І - G M d g -І - PM D G - ІІ +І ІІ - G M D G - ІІ +І ІІ - PM N G -G M N G -P M TC - G M TC -P M H T- G M H T- P M Тt -g M Тt -P M Тd -g M ES D -G M 1 ES D -P M 0. 84 1* 1 d g -І -g M 0. 88 2* 0. 76 4* 1 d g -І -P M 0. 84 4* 0. 90 6* 0. 91 6* 1 d g -І І+ ІІ І- g M 0. 85 8* 0. 69 2* 0. 78 3* 0. 71 4* 1 d g -І І+ ІІ І- PM 0. 79 7* 0. 75 0* 0. 71 7* 0. 71 6* 0. 92 0* 1 N G -G M 0. 36 0^ 0. 03 7 0. 16 0 0. 02 3 0. 35 0^ 0. 26 5 1 N G - P M 0. 16 0 -0 .1 24 0. 02 3 -0 .1 51 0. 23 5 0. 17 6 0. 82 2* 1 TC - G M -0 .1 14 -0 .4 22 ’’ -0 .3 35 ^ -0 .4 99 * -0 .0 56 -0 .1 44 0. 64 0* 0. 70 2* 1 TC - P M -0 .1 84 -0 .4 88 * -0 .3 28 ^ -0 .4 93 * -0 .1 59 -0 .2 19 0. 69 1* 0. 71 7* 0. 91 1* 1 H T- G M 0. 23 4 0. 18 4 0. 04 1 0. 06 3 0. 03 4 0. 07 3 0. 32 3^ 0. 33 2^ 0. 19 4 0. 15 6 1 H T- P M 0. 07 9 0. 06 3 -0 .1 04 -0 .0 83 -0 .0 60 -0 .0 01 0. 29 1 0. 44 2’ ’ 0. 32 5^ 0. 25 3 0. 86 8* 1 TT - G M 0. 55 9* 0. 46 9’ ’ 0. 39 6’ ’ 0. 40 9’ ’ 0. 39 2’ ’ 0. 30 8 0. 21 1 0. 02 1 -0 .0 53 -0 .1 69 0. 22 3 0. 18 3 1 tТ - P M 0. 24 5 0. 21 7 0. 13 2 0. 18 1 0. 19 0. 25 9 0. 41 8’ ’ 0. 31 3 -0 .0 33 0. 00 9 0. 43 0’ ’ 0. 50 7* 0. 49 4* 1 Тd - g M -0 .1 63 -0 .3 38 ^ -0 .2 46 -0 .4 08 ’’ -0 .1 22 -0 .1 58 0. 38 8’ ’ 0. 67 2* 0. 77 2* 0. 67 3* 0. 37 6^ 0. 54 5* -0 .1 18 -0 .0 92 1 Тd - P M -0 .1 53 -0 .3 22 -0 .2 48 -0 .3 97 ’’ -0 .1 75 -0 .1 84 0. 37 9^ 0. 69 8* 0. 70 1* 0. 64 2* 0. 45 6’ ’ 0. 67 2* -0 .0 83 0. 06 5 0. 94 0* N ot e. S pe ar m an ’s ra nk c or re la tio n co effi ci en ts (п = 27 ): * – r s ta bl =0 .4 87 a t р =0 .0 1; ’’ – r s ta bl л =0 .3 81 a t р =0 .0 5; ^ – r s ta bl = 0. 32 3 at р =0 .1 . Co nt in ua tio n of ta bl e 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 So ut he rn О de sa 20 23 ’’ 26 ’’ 27 ’’ 25 ’’ 26 ’’ 23 ’’ 26 ’’ 14 14 15 16 11 25 ’’ 20 17 Kh er so n 23 ’’ 22 ’’ 25 ’’ 26 ’’ 18 23 ’’ 6* * 7* * 3* * 3* * 9 11 22 ’’ 20 4* * 7, 5* * Cr im ea 14 11 9 8 23 ’’ 20 15 17 20 17 12 7* * 18 9 18 16 Se va st op il 25 ’’ 27 ’’ 27 ’’ 25 ’’ 27 ’’ 27 ’’ 14 24 ’’ 5* * 5* * 20 22 ’’ 23 ’’ 21 ’’ 16 21 ’’ N ot e. ** – th e hi gh es t l ev el s of m or bi di ty , ’ ’ – th e lo w es t l ev el s of m or bi di ty . А. М. Antonenko et al. ISSN 2413-6077. IJMMR 2018 Vol. 4 Issue 156 P U B L IC H E A LT H A N D E P ID E M IO L O G Y lowest rates of diffuse goiter of different degrees are presented in Table 1. However, it should be noted that in the regions that occupy the last ranked positions according to the levels of both morbidity indices, AIR and IR were high. On the contrary, in regions with a high morbidity, AIR and IR were low or even negative. this was confirmed by the Spearman’s rank correlation coefficients, which proved a statistically significant backward correlation between the level and the IR of the total (rs=-0.576; rs tabl=0.478 at n=27, p=0.01) and the primary (rs=-0.509, p<0.01) incidence of endocrinopathies among the population of 27 investigated AT of Ukraine. In general, the incidence rates of adult population for endocrine diseases correlate with the prevalence and morbidity rates of diffuse goiter of various degrees (Table 2), which is explained by a high specific gravity of the latter in the structure of endocrine diseases. Thus, in Ukraine in 2010, in the structure of endocrinopathy, diffuse goiter of degrees I-III was the second (29.99 %) after diabetes mellitus (31.88 %), and the share of all thyroid gland diseases was 46.67 % [14]. In the analysis of both indices of thyroid morbidity, it was found out that during the period of investigation, the highest levels were registered in the western and northern regions of Ukraine, and the lowest ones were in the central, eastern and southern (except in the Autonomous Republic of Crimea) regions (Fig. 1). At the same time, in most of the western and northern regions during 14 years there was a decrease in both (volyn, lviv, Zakarpattia, Ivano-Frankivsk, Sumy oblasts), or one (Ternopil, Zhytomyr, Kyiv, Chernihiv) of the morbidity indices, while the changes in the other were insignificant (fig. 2). Kyiv was the exception: both indices, especially the level of general morbidity, increased; in Rivne and Chernivtsi regions the general morbidity significantly increased without significant changes in the primary one, and in Khmelnitsky region significant changes in both indices did not take place. The situation in the central, eastern and southern regions was the opposite, where in the majority of regions there was a significant increase in both (Cherkasy, Poltava, Kharkiv, Donetsk, Zaporizhia, Mykolaiv, Odesa) or one (vinnytsia, Dnipro- petrovsk, Kherson, luhansk regions and Sevastopil) of indices with minor changes of the other. Kirovograd region and Crimea were the exceptions: the general morbidity did not Fig. 1. Thyroid morbidity. А. М. Antonenko et al. ISSN 2413-6077. IJMMR 2018 Vol. 4 Issue 1 57 P U B L IC H E A LT H A N D E P ID E M IO L O G Y change significantly, and the primary one – decreased (Fig. 2). Thus, in relation to thyroid pathology, as well as in case of endocrine diseases in general, a statistically significant inverse relationship between the level and IR of the general (rs= -0.687, p<0.001) and primary (rs=-0.735, p<0.001) morbidity of adult population in 27 investigated AT of Ukraine was revealed. Concerning certain nosological forms of thyroid pathology, during the period of mo- nitoring, significant regional features were revealed both for the levels of morbidity indices and the direction of their changes in the period of study. Thus, the levels of primary and general morbidity of diffuse goiter (DG) were the highest in the western (Zakarpattia, Rivne and volyn regions – DG of degrees I and II–III, Chernivtsi – DG of degrees II–III, lviv and Ivano- Frankivsk – DG of degree I) and northern (Kyiv, Sumy, Chernihiv) regions, and the lowest ones – in the eastern (Donetsk) and southern (Odesa, Zaporizhia, Kherson regions and Sevastopil) regions (Table 1). During 14 years of the study, the general morbidity rate for diffuse goiter of degrees I (dg-i) and ІІ–ІІІ (dg-ІІ–ІІІ) in 11 and 6 regions Fig. 2. Dynamics of changes in the thyroid general and primary morbidity. respectively decreased, in 8 and 13 AT – increased, which was confirmed by statistically significant correlation coefficients. in 3 and 2 AT respectively, there was a tendency to increase (0.707>r>0.622, 0.05r>0.622, 0.050.707, p<0.05); in three – it did not change significantly, remaining steadily high in Kyiv and Sumy regions; and in volyn and Zhytomyr – decreased ( r = - 0 . 9 0 8 , p < 0 . 0 1 a n d - 0 . 7 4 8 , p < 0 . 0 5 , respectively). Regarding the overall incidence of thyroid cancer, in general in the period of 2000–2013 there was no statistically significant relationship in the period of monitoring between 25 out of 27 AT (p>0.05), only in Kyiv region the increase (r=0.784 , p<0.05) took place, while in Chernivtsi – the decrease (r=-0.716, p<0.05) of the index. The primary incidence of thyroid cancer in the period of investigation increased in 15 regions and the Crimea Autonomous Republic (r>0.707, p<0.05), while in 4 regions (Rivne, Zhytomyr, Kropyvnytskyi, and Odesa), there was a tendency to increase (0.707>r>0.622, 0.050.05). The highest levels of both indices of the incidence of adult thyroiditis in Ukraine were registered in Kyiv city, Kharkiv, Donetsk, Kyiv, Dnipropetrovsk and Kherson regions, and the lowest – in Ternopil, volyn, luhansk, Zakarpattia and Rivne regions (Table 1). In general, both thyroiditis morbidity indices correlated with the incidence of thyroid cancer, nodular goiter and hypothyroidism (Table 2). During the study period, the overall in- cidence of thyroiditis, hypothyroidism and thyrotoxicosis increased in most (24, 20 and 26, respectively) of the studied AT, which was confirmed by a statistically significant positive coefficient of correlation. Regarding the pri- mary morbidity of thyroiditis, hypothyroidism and thyrotoxicosis, the indices increased in 13, 17 and 11 respectively. Discussion The regional peculiarities of the levels and dynamics of changes in the incidence rates of the thyroid morbidity among adult population of Ukraine can be related to the priority envi- ronmental factors for each region. It is esta b- lished that the western and northern regions of Ukraine are different from the rest of the low natural content in the soil of iodine. The northern (Kyiv, Chernihiv, Zhytomyr, Rivne) and Cherkasy regions are significantly conta- minated by radioactive substances, including radioactive iodine isotopes (predominantly I-131), as a result of the Chernobyl accident. In the eastern region, Dnipropetrovsk and Zapo- rizhia regions, powerful industrial centers are concentrated, in which relatively high levels of environmental pollution by industrial toxicants, including heavy metals, are registered. The central and southern regions have developed agricultural production, which today widely uses chemical protection products for plants. The study of the environmental factors in- fluence on the Ukrainian adult population thyroid morbidity will be a topical issue of our further research. Conclusions In the period from 2000 to 2013, high levels of adult population endocrinopathies, thyroid glands in general and diffuse goiter of varying degrees, general and primary morbidity have been recorded in the western and northern regions of Ukraine, low – in the central, eastern and southern regions. Statistically significant (p<0.001) positive correlation between the level of prevalence and the level of incidence of endocrine pathology, diseases of thyroid gland as a whole, as well as individual nosology has been detected. 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Intern Journal of Endocrinology 2011;3 (35):1–7. Received: 2018-05-10 А. М. Antonenko et al. АНАЛІЗ ЗАХВОРЮВАНОСТІ ДОРОСЛОГО НАСЕЛЕННЯ УКРАЇНИ НА ПАТОЛОГІЮ ЩИТОПОДІБНОЇ ЗАЛОЗИ З 2000 ПО 2013 РОКИ А. М. Антоненко, М. М. Коршун, О. П. Вавріневич, С. Т. Омельчук, В. Г. Бардов НАЦІОНАЛЬНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ ІМЕНІ О. О. БОГОМОЛЬЦЯ, КИЇВ, УКРАЇНА Вступ. Патологія щитоподібної залози останнім часом привертає значну увагу фахівців клінічної та профілактичної медицини. Частково це пов’язано з тим, що щитоподібна залоза активно реагує на геохімічний стан і забруднення навколишнього середовища промисловими і сільськогосподарськими відходами з наступним поширенням певних патологічних процесів. Метою дослідження було проаналізувати захворюваність дорослого населення України на захворювання щитовидної залози в період з 2000 по 2013 роки. Методи. Використовувалися методи емпіричного та теоретичного дослідження наукової інформації: аналіз, синтез, індукція, дедукція та систематизація, а також епідеміологічні та статистичні методи. За допомогою програми Microsoft Office Excel (2007) та програми IBM SPSS StatisticsBase v.22 були проведені кореляційний та регресійний аналіз. Результати. З 2000 по 2013 рр. зареєстровано високий рівень загальної та первинної захворюваності на ендокринопатії, дифузний токсичний та ендемічний зобу у дорослого населення західних і північних областей України, низький рівень – у центральних, східних і південних регіонах. Виявлено статистично значущу (p <0,001) позитивну кореляцію між рівнем поширеності та рівнем захворюваності ендокринною патологією, захворюваннями щитовидної залози, а також окремою нозологією. Висновки. Регіональні особливості рівню та динаміки частоти захворюваності щитовидної залози серед дорослого населення України можуть бути пов’язані з екологічними факторами у кожному регіоні. Цей фактор потребує подальшого вивчення для розробки ефективних методів профілактики та захисту. КЛЮЧОВІ СЛОВА: захворюваність; щитоподібна залоза; дорослe населення, Україна.