# bib

id: cord-034640-ygtbuy4k
title: Corrigenda
date: 2020-11-04
extension: .txt
mime: text/plain
words: 265
sentence: 10
flesch: 29
cache: cache/cord-034640-ygtbuy4k.txt
txt: txt/cord-034640-ygtbuy4k.txt
summary:
  COVID-19: start with the nose SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract Detection of rhinovirus RNA in lower airway cells during experimentally induced infection Effect of dexamethasone in hospitalized patients with COVID-19: preliminary report Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2 ), it has been brought to the Editors' attention that the authors' names were incorrect as printed. key: cord-034640-ygtbuy4k authors: nan title: Corrigenda date: 2020-11-04 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.08.023 sha: doc_id: 34640 cord_uid: ygtbuy4k nan corticosteroids on COVID-19 outcomes.


id: cord-346835-gg3xespb
author: Navel, Valentin
date: 2020-04-26
extension: .txt
mime: text/plain
words: 412
sentence: 11
flesch: 18
cache: cache/cord-346835-gg3xespb.txt
txt: txt/cord-346835-gg3xespb.txt
title:
  Will environmental impacts of social distancing due to the SARS-CoV-2 pandemic decrease allergic disease?

summary:
  8 Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study Obesity May Enhance the Adverse Effects of NO2 Exposure in Urban Schools on Asthma Symptoms in Children Climate Change and the Impact on Respiratory and Allergic Disease Change Research Program Effects on asthma and respiratory allergy of Climate change and air pollution Airborne Nitrogen Dioxide Plummets Over China Nitrogen dioxide concentrations over France Air pollution is a causative factor for both various symptoms such as bronchospasm, rhinorrhea, eye redness, and irritation, as well as various allergic diseases such as asthma, chronic rhinitis, nasal polyposis, atopic dermatitis, seasonal or perennial allergic conjunctivitis, and vernal or atopic keratoconjunctivitis.


id: cord-341650-f8orw6ro
author: Li, Hailan
date: 2020-09-17
extension: .txt
mime: text/plain
words: 512
sentence: 13
flesch: 42
cache: cache/cord-341650-f8orw6ro.txt
txt: txt/cord-341650-f8orw6ro.txt
title:
  Regarding “Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial”

summary:
  1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): a multicenter, singleblind, randomized controlled trial Risk factors associated with disease severity and length of hospital stay in COVID-19 patients Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicentre) and outside Hubei (non-epicentre): a nationwide analysis of China A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19 Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study Imaging features and evolution on CT in 100 COVID-19 pneumonia patients in Wuhan, China Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study key: cord-341650-f8orw6ro authors: Li, Hailan; Liu, Huaping title: Regarding “Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial” date: 2020-09-17 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.09.002 sha: doc_id: 341650 cord_uid: f8orw6ro nan Regarding ''Ruxolitinib in Q 1 treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, singleblind, randomized controlled trial'' Q 2 To the Editor:


id: cord-328210-qhl429fm
author: Gelardi, Matteo
date: 2020-06-24
extension: .txt
mime: text/plain
words: 666
sentence: 26
flesch: 43
cache: cache/cord-328210-qhl429fm.txt
txt: txt/cord-328210-qhl429fm.txt
title:
  The clinical relevance of the clinical cytological grading in patients with chronic rhinosinusitis with nasal polyps

summary:
  The sense of smell in chronic rhinosinusitis EPOS2020: European Position Paper on Rhinosinusitis and Nasal Polyps 2020 EUFOREA consensus on biologics for CRSwNP with or without asthma Role of nasal cytology Standardization of the nasal cytology in the work-up of allergic rhinitis Non-surgical management of chronic rhinosinusitis with nasal polyps based on clinical cytological grading: a precision medicine-based approach Olfactory dysfunction in patients with chronic rhinosinusitis with nasal polyps is associated with clinical-cytological grading severity key: cord-328210-qhl429fm authors: Gelardi, Matteo; Cassano, Michele; Ciprandi, Giorgio title: The clinical relevance of the clinical cytological grading in patients with chronic rhinosinusitis with nasal polyps date: 2020-06-24 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.04.049 sha: doc_id: 328210 cord_uid: qhl429fm nan The clinical relevance of the clinical cytological grading in patients with chronic rhinosinusitis with nasal polyps To the Editor:


id: cord-010159-uo47oab1
author: Jartti, Tuomas
title: Respiratory viruses and acute asthma in children
date: 2007-04-02
extension: .txt
mime: text/plain
words: 574
sentence: 25
flesch: 48
cache: cache/cord-010159-uo47oab1.txt
txt: txt/cord-010159-uo47oab1.txt
summary:
  key: cord-010159-uo47oab1 authors: Jartti, Tuomas; Waris, Matti; Niesters, Hubert G.M.; Allander, Tobias; Ruuskanen, Olli title: Respiratory viruses and acute asthma in children date: 2007-04-02 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2007.02.025 sha: doc_id: 10159 cord_uid: uo47oab1 nan To the Editor: We read with great interest the article by Khetsuriani et al 1 on the prevalence of respiratory tract viruses in children with asthma. Prevalence of viral respiratory tract infections in children with asthma Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children Human bocavirus and acute wheezing in children Guidelines for the diagnosis and management of asthma-update on selected topics Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Available online April 13


id: cord-032811-sdbj26ca
author: Hosoki, Koa
title: Reply
date: 2020-09-29
extension: .txt
mime: text/plain
words: 667
sentence: 25
flesch: 39
cache: cache/cord-032811-sdbj26ca.txt
txt: txt/cord-032811-sdbj26ca.txt
summary:
  Because IFN-l contributes to loss of lung epithelial barrier function, 8 we hypothesize that entry of SARS-CoV-2 via ACE-2 can stimulate secretion of IFN-l and induce leakage of fluid into the lungs (Fig 1, A) . Thus, until the effect of SARS-CoV-2 on ACE-2 levels or functionality is thoroughly addressed in peer-reviewed publications, it is difficult to precisely determine the contributory role of ACE-2 in the bradykinin pathway during SARS-CoV-2 infection.


id: cord-327076-qq5499qg
author: Siniorakis, Eftychios
date: 2020-09-29
extension: .txt
mime: text/plain
words: 722
sentence: 27
flesch: 35
cache: cache/cord-327076-qq5499qg.txt
txt: txt/cord-327076-qq5499qg.txt
title:
  COVID-19 and upper respiratory tract: Collecting swab specimens from patients inhaling corticosteroids

summary:
  1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 Perspective: COVID-19, implications of nasal diseases and consequences for their management How to obtain a nasopharyngeal swab specimen Determinants of the nasal microbiome: pilot study of effects of intranasal medication use Long-term impact of inhaled corticosteroid use in asthma and chronic obstructive pulmonary disease (COPD): review of mechanisms that underlie risks The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15 Inhibitory effects of glucopyrronium, formoterol, and budesonide in coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs key: cord-327076-qq5499qg authors: Siniorakis, Eftychios; Arvanitakis, Spyridon; Sfakianaki, Titika; Katsianis, Antonios; Sinaniotis, Athanasios; Papagiannopoulou, Veneta title: COVID-19 and upper respiratory tract: Collecting swab specimens from patients inhaling corticosteroids date: 2020-09-29 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.09.004 sha: doc_id: 327076 cord_uid: qq5499qg nan Correspondence COVID-19 and upper respiratory tract: Collecting swab specimens from patients inhaling corticosteroids Q 1 To the Editor: Jian et al 1 in a recent article refer to the immune reaction of the upper respiratory tract (URT) in patients infected by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 (coronavirus disease 2019


id: cord-025380-6bagohw8
author: Navel, Valentin
title: Reply
date: 2020-05-28
extension: .txt
mime: text/plain
words: 756
sentence: 18
flesch: 30
cache: cache/cord-025380-6bagohw8.txt
txt: txt/cord-025380-6bagohw8.txt
summary:
  Globally, emerging data may identify air pollution as a modulator to DNA methylation (DNAm) disturbing the inflammation process, allergic diseases development, and exacerbation risk. Considering that SARS-CoV-2 infection involves a proinflammatory cytokine storm as IL-6 and IL-1b, a putative hypothesis could explain that populations exposed to chronic air pollution are associated with a different COVID-19 incidence in line with chronic epigenetic deregulation.


id: cord-270635-l8380adr
author: Maggi, Enrico
title: COVID-19: unanswered questions on immune response and pathogenesis
date: 2020-05-08
extension: .txt
mime: text/plain
words: 881
sentence: 39
flesch: 51
cache: cache/cord-270635-l8380adr.txt
txt: txt/cord-270635-l8380adr.txt
summary:
  -Relative higher frequency of CD8+ than CD4+ T cells in recovered patients. -Highly activated CD4+ and CD8+ T cells with predominant type 1 or type 3 profiles in severe patients. -Time of onset, phenotype, repertoire, functional profile and amplitude of T cell response still unknown.


id: cord-313058-nrrl4kjc
author: Rivas, Magali Noval
date: 2020-10-16
extension: .txt
mime: text/plain
words: 1058
sentence: 28
flesch: 29
cache: cache/cord-313058-nrrl4kjc.txt
txt: txt/cord-313058-nrrl4kjc.txt
title:
  COVID-19 Associated Multisystem Inflammatory Syndrome in Children (MIS-C): a novel disease that mimics Toxic Shock Syndrome. The superantigen hypothesis

summary:
  It 99 will be interesting to determine whether these neurotoxin-like sequences in the SARS-100 CoV-2 S protein contribute to the neurological manifestations observed in children with 101 Why only a small fraction of SARS-CoV-2 infected children develop MIS-C 103 remains unclear. Given the structural similarities between SEB and the SARS-114 J o u r n a l P r e -p r o o f CoV-2 S protein SAg motif 5 , it is possible that antibodies within IVIG that neutralize 115 SEB cross-react with SARS-CoV-2 S, which may in part explain the beneficial response 116 of MIS-C cases to IVIG.


id: cord-007866-2d6003r9
author: Renz, Harald
title: Autophagy: Nobel Prize 2016 and allergy and asthma research
date: 2017-04-08
extension: .txt
mime: text/plain
words: 1055
sentence: 41
flesch: 37
cache: cache/cord-007866-2d6003r9.txt
txt: txt/cord-007866-2d6003r9.txt
summary:
  Although little work has been carried out in this regard thus far, there are convincing data available linking autophagy in airway epithelium, and autophagy might be essential for bronchial epithelial mucus secretion, as has been shown in an allergic asthma model. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction A protein conjugation system essential for autophagy A ubiquitin-like system mediates protein lipidation Eosinophil cytolysis requires the RIPK3-MLKL signaling pathway and is counter-regulated by autophagy Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target IL13 activates autophagy to regulate secretion in airway epithelial cells The complex roles of endoplasmic reticulum stress and autophagy in modulating Eotaxin-3 production and secretion from human airway epithelial cells Anti-nerve growth factor antibody reduces airway hyperresponsiveness in a mouse model of asthma by downregulating the level of autophagy in lungs Astragalin inhibits autophagy-associated airway epithelial fibrosis Autophagy is involved in influenza A virus replication Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes Genetic and histologic evidence for autophagy in asthma pathogenesis The first autophagy gene, ATG1 Ohsumi


id: cord-027511-j5ayp0tv
author: Navel, Valentin
title: Reply
date: 2020-06-22
extension: .txt
mime: text/plain
words: 800
sentence: 25
flesch: 31
cache: cache/cord-027511-j5ayp0tv.txt
txt: txt/cord-027511-j5ayp0tv.txt
summary:
  To conclude, it will be salient to analyze the aforementioned factors related to allergic diseases in forthcoming months, to better understand the complex relation between allergens, air pollution, immune response, and exacerbation of allergic diseases. Similar to the concentration of diesel exhaust particles in a vehicle cabin exposed to heavy traffic, nonventilated houses could condense the toxicity of outdoor air pollution during several days.


id: cord-272214-rwkfev8j
author: Kaplan, Allen P.
date: 2020-10-28
extension: .txt
mime: text/plain
words: 1291
sentence: 43
flesch: 46
cache: cache/cord-272214-rwkfev8j.txt
txt: txt/cord-272214-rwkfev8j.txt
title:
  Pathways for Bradykinin Formation and Interrelationship with Complement as a Cause of Edematous Lung in COVID-19 Patients

summary:
  Factor XII activation proceeds by a relatively 66 slow autoactivation process to produce a small amount of factor XIIa and a very rapid positive 67 feedback in which the initial kallikrein formed activates all remaining factor XII in seconds to 68 yield factor XIIa and then factor XIIf. Studies of gene expression in 97 bronchoalveolar lavage specimens of COVID-19 patients(5), when compared to normal control 98 specimens, reveal upregulation of multiple components that lead to bradykinin production and 99 expression for C1-INH was decreased 33-fold which would render the plasma bradykinin 102 cascade labile and overreactive as we see in C1-INH deficiency (types I and II HAE) in which 103 enzymes not adequately inhibited by C1-INH include both forms of activated factor XII, plasma 104 kallikrein, and C1r.


id: cord-304320-1oaobtlx
author: Lee, Pui Y.
date: 2020-08-25
extension: .txt
mime: text/plain
words: 1375
sentence: 54
flesch: 42
cache: cache/cord-304320-1oaobtlx.txt
txt: txt/cord-304320-1oaobtlx.txt
title:
  Immune dysregulation and Multisystem Inflammatory Syndrome in Children (MIS-C) in individuals with haploinsufficiency of SOCS1

summary:
  2, 4 In a recent study detailing 88 outcomes of whole-genome sequencing for patients with primary immunodeficiency, SOCS1 89 haploinsufficiency was briefly described in two individuals with recurrent bacterial infections and 90 severe multi-systemic autoimmunity. In contrast, the 181 expression of CD32, which is not regulated by interferon signaling, was similar between patients 182 and controls (Fig. 2C) .


id: cord-252950-eiphxwmn
author: Trouillet-Assant, Sophie
title: Type I IFN immunoprofiling in COVID-19 patients
date: 2020-04-29
extension: .txt
mime: text/plain
words: 1558
sentence: 71
flesch: 44
cache: cache/cord-252950-eiphxwmn.txt
txt: txt/cord-252950-eiphxwmn.txt
summary:
  Clinical features of patients infected with 114 2019 novel coronavirus in Wuhan, China COVID-19: 116 consider cytokine storm syndromes and immunosuppression TYPE I INTERFERONS (α/β) IN IMMUNITY 118 AND AUTOIMMUNITY /679 and Directive 95/46/EC) and the French data protection law (Law n°78-17 on 06/01/1978 and Décret n°2019-536 on 29/05/2019), we obtained consent from each patient or his next of kin USA) on plasma samples of COVID-19 patients. 61 In this study, we assessed the kinetics of plasma IFN-I in COVID-19 patients with a spectrum of 62 severity degree.


id: cord-284576-nemh4wdo
author: Sims, Jonathan T.
date: 2020-09-10
extension: .txt
mime: text/plain
words: 1652
sentence: 43
flesch: 22
cache: cache/cord-284576-nemh4wdo.txt
txt: txt/cord-284576-nemh4wdo.txt
title:
  Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19

summary:
  Proceedings of the National Academy of 254 Sciences CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human 257 alveolar epithelial cells type II A systems approach to inflammation identifies therapeutic targets in SARS-260 CoV-2 infection Remdesivir in adults with severe 262 COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Comparison of an ordinal endpoint to time-to-event, longitudinal, and binary endpoints for use in 266 evaluating treatments for severe influenza requiring hospitalization Anticoagulant treatment is associated with 269 decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Prevalence of venous thromboembolism in patients 272 with severe novel coronavirus pneumonia Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and 275 call for action Soluble 277 CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with 278 and without overt ischemic heart disease Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular 283 diseases: the therapeutic potential of PARP inhibitors key: cord-284576-nemh4wdo authors: Sims, Jonathan T.; Krishnan, Venkatesh; Chang, Ching-Yun; Engle, Sarah M.; Casalini, Giacomo; Rodgers, George H.; Bivi, Nicoletta; Nickoloff, Brian J.; Konrad, Robert J.; de Bono, Stephanie; Higgs, Richard E.; Benschop, Robert J.; Ottaviani, Silvia; Cardoso, Anabela; Nirula, Ajay; Corbellino, Mario; Stebbing, Justin title: Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19 date: 2020-09-10 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.08.031 sha: doc_id: 284576 cord_uid: nemh4wdo Background Physicians treating COVID-19 patients increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a cytokine storm.


id: cord-303135-rx21ajiw
author: Jian, Li
title: Perspective: COVID-19, implications of nasal diseases and consequences for their management
date: 2020-05-01
extension: .txt
mime: text/plain
words: 1724
sentence: 56
flesch: 37
cache: cache/cord-303135-rx21ajiw.txt
txt: txt/cord-303135-rx21ajiw.txt
summary:
  5 To invade the cell, there is need for another player, the transmembrane protease TMPRSS2, a serine protease expressed in airway epithelial cells, mucosal glands, and inflammatory cells such as macrophages, that activates the viral S protein and enables human airway cell entry. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China SARS-CoV-2 viral load in upper respiratory specimens of infected patients Letter: Precautions for endoscopic transnasal skull base surgery during the COVID-19 pandemic Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro SARS-CoV-2 entry genes are most highly expressed in nasal goblet and ciliated cells within human airways SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: an ARIA-EAACI statement


id: cord-344759-7zs389m9
author: Shilts, Meghan H.
date: 2020-07-03
extension: .txt
mime: text/plain
words: 1818
sentence: 58
flesch: 35
cache: cache/cord-344759-7zs389m9.txt
txt: txt/cord-344759-7zs389m9.txt
title:
  Nasopharyngeal Haemophilus and Local Immune Response during Infant Respiratory Syncytial Virus Infection

summary:
  In general, the nasopharyngeal relative abundance of Haemophilus was 157 associated with higher levels of local immune mediators with anti-viral and/or pro-inflammatory 158 functions, as well as those important in the chemotaxis, differentiation, proliferation, and 159 survival of numerous immune cells (e.g., TNF-α, IFN-α, IL-1β, IL-6, IL-8, IL-12, IL-21, and IL-160 28A). Only the estimates for local immune mediators with q-values <0.05 in unadjusted analyses and that remained significant in adjusted analyses are shown.


id: cord-347512-veavzt6d
author: Ueland, Thor
title: Elevated plasma sTIM-3 levels in severe Covid-19 patients
date: 2020-09-21
extension: .txt
mime: text/plain
words: 1928
sentence: 69
flesch: 44
cache: cache/cord-347512-veavzt6d.txt
txt: txt/cord-347512-veavzt6d.txt
summary:
  Methods We analyzed plasma levels of myeloperoxidase (MPO, neutrophil activation), soluble (s) CD25 and soluble T cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T cell activation and exhaustion) and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19 infected patients at hospital admission and two additional times during the first 10 days in relation to the need for ICU treatment. Finally, the two markers of T cell activation, sCD25 and sTIM-3, were strongly correlated (r=0.71, p<0.001).


id: cord-334801-p5mxc694
author: Van Singer, Mathias
title: COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department
date: 2020-10-09
extension: .txt
mime: text/plain
words: 2030
sentence: 88
flesch: 43
cache: cache/cord-334801-p5mxc694.txt
txt: txt/cord-334801-p5mxc694.txt
summary:
  A recent study identified different inflammatory cytokine profiles according to the stage 97 of the disease, suggesting their usefulness for risk stratification in COVID-19 patients (13). This prospective observational cohort study of COVID-19 patients was conducted in the ED 120 of Lausanne University Hospital (CHUV), a tertiary care center in Switzerland.


id: cord-007385-xcx4ic0s
author: Spector, Sheldon L.
title: The common cold: Current therapy and natural history()()()
date: 2005-11-30
extension: .txt
mime: text/plain
words: 2045
sentence: 73
flesch: 32
cache: cache/cord-007385-xcx4ic0s.txt
txt: txt/cord-007385-xcx4ic0s.txt
summary:
  The effect of intranasal nedocromil sodium on viral upper respiratory tract infections in human volunteers Intranasal sodium cromoglycate in post-catarrhal hyperreactive rhinosinusitis: a double-blind placebo controlled trial The effects of menthol on reaction time and nasal sensation of airflow in subjects suffering from the common cold Ineffectiveness of recombinant interferon-beta serine nasal drops for prophylaxis of natural colds Ineffectiveness of postexposurc prophylaxis of rhinovirus infection with lowdose intranasal alpha 2b interferon in families Recombinant human interferon-gamma as prophylaxis against rhinovirus colds in volunteers A randomized controlled trial of glucocorticoid prophylaxis against experimental rhinovirus infection Effect of inhaling heated vapor on symptoms of the common cold Effect of inhaling heated vapor on symptoms of the common cold Local hyperthermia benefits natural and experimental common colds Regular sauna bathing and the incidence of common colds Zinc gluconate lozenges for common cold: a double-blind clinical trial Zinc gluconate and the common cold: a controlled clinical study Vitamin C and the common cold Does vitamin C alleviate the symptoms of the common cold?: a review of current evidence Effects of drinking hot water, cold water, and chicken soup on nasal ¢,~ ~pec'~or ~ucus velocity and nasal airflow resistance Therapeutic effects of an anticboinergic-sympathomimetic combination in induced rhinovirus colds A double-blind, placebo-controlled study of the safety and efficacy of ipratropium bromide nasal spray versus placebo in patients with the common cold Modification of experimental rhinovirus colds by receptor blockade Common cold Kinins are generated in nasal secretions during natural rhinovirus colds A study of the efficacy of the bradykinin antogonist, NPC 567, in rhinovirus infections in human volunteers Peripheral blood mononuclear cell interleukin-2 and interferon-gamma production, cytotoxicity, and antigenstimulated blastogenesis during experimental rhinovirus infection Effect of rhinovirus 39 infection on cellular immune parameters in allergic and nonallergic subjects Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds Chemotherapy of rhinovirus colds Respiratory viruses and exacerbations of asthma in adults Computed tomographic study of the common cold Physiologic abnormalities in the paranasal sinuses during experimental rhinovirus colds Middle ear abnormalities during natural rhinovirus colds in adults Effect of experimental rhinovirus 39 infection on the nasal response to histamine and cold air challenges in allergic and nonallergic subjects Amplified rhinovirus colds in atopic subjects Factors affecting the long-term variability of bronchial responsiveness in an adult general practice population Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers Effects of naproxen on experimental rhinovirus colds: a randomized, double-blind, controlled trial Pathophysiology and pharmacotherapy of common upper respiratory diseases Evaluation of an alpha agonist alone and in combination with a nonsteroidal antiinflammatory agent in the treatment of experimental rhinovirus colds Evaluation of oral terfenadine for treatment of the common cold Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial Over-the-counter cold medications: a critical review of clinical trials between 1950 and 1991


id: cord-255794-55ubow92
author: Galván-Román, José María
title: IL-6 serum levels predict severity and response to Tocilizumab in COVID-19: an observational study
date: 2020-09-30
extension: .txt
mime: text/plain
words: 2800
sentence: 108
flesch: 50
cache: cache/cord-255794-55ubow92.txt
txt: txt/cord-255794-55ubow92.txt
summary:
  In this regard, recent studies have 193 indicated the usefulness of IL-6 serum levels, lymphocyte count, fibrinogen or D-dimer to 194 evaluate the development of ARDS and its mortality (8-11). Even before physicians were aware of the potential value of IL-6 serum levels as a predictor of 375 severe disease, those patients with high IL-6 were more frequently treated with TCZ ( Figure 376 1D; AUC 0.634; 30 pg/ml as cut-off showed Se 57%, Sp 69%,


id: cord-284053-tna7e9dw
author: Kimura, Hiroki
title: Type 2 Inflammation Modulates ACE2 and TMPRSS2 in Airway Epithelial Cells
date: 2020-05-15
extension: .txt
mime: text/plain
words: 2967
sentence: 120
flesch: 44
cache: cache/cord-284053-tna7e9dw.txt
txt: txt/cord-284053-tna7e9dw.txt
summary:
  248 We next examined the association of nasal epithelial cell ACE2 expression with 249 T2 cytokines. Objective To extend our work in interleukin (IL)-13 biology to determine if airway epithelial cell expression of two key mediators critical for SARS-CoV-2 infection, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) are modulated by IL-13. Methods We determined effects of IL-13 treatment on ACE2 and TMPRSS2 expression ex vivo in primary airway epithelial cells from participants with and without type 2 asthma obtained by bronchoscopy.


id: cord-286477-0euaaspo
author: Li, Xiaochen
title: Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
date: 2020-04-12
extension: .txt
mime: text/plain
words: 3244
sentence: 142
flesch: 51
cache: cache/cord-286477-0euaaspo.txt
txt: txt/cord-286477-0euaaspo.txt
summary:
  Severe patients treated with corticosteroids had higher LDH level compared 283 with severe patients without corticosteroid use pre-admission (P<0.05). Cox proportional hazard regression model was used for survival analysis in severe patients.


id: cord-264311-t81r2l3r
author: Toivonen, Laura
date: 2019-01-14
extension: .txt
mime: text/plain
words: 3596
sentence: 138
flesch: 33
cache: cache/cord-264311-t81r2l3r.txt
txt: txt/cord-264311-t81r2l3r.txt
title:
  Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

summary:
  A, Between the 4 virus categories, the proportion of nasopharyngeal microbiota profiles differed. In the current analysis, we grouped infants into 4 mutually exclusive virus categories: solo RSV (reference), RV-A, RV-B, and RV-C. We tested the association between these virus categories and nasopharyngeal microbiota profiles by constructing multinomial logistic regression model adjusting for 8 covariates.


id: cord-260700-u12aa739
author: Kainulainen, Leena
date: 2010-06-10
extension: .txt
mime: text/plain
words: 3695
sentence: 206
flesch: 43
cache: cache/cord-260700-u12aa739.txt
txt: txt/cord-260700-u12aa739.txt
title:
  Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia

summary:
  The occurrence of respiratory tract viral infections in patients with primary hypogammaglobulinemia has not been studied. Despite adequate immunoglobulin replacement therapy, patients with primary hypogammaglobulinemia have increased susceptibility to respiratory tract viral infections.


id: cord-304549-e8q8mck4
author: Holgate, Stephen T.
title: Genetic and environmental interaction in allergy and asthma()()
date: 2005-11-02
extension: .txt
mime: text/plain
words: 4710
sentence: 167
flesch: 35
cache: cache/cord-304549-e8q8mck4.txt
txt: txt/cord-304549-e8q8mck4.txt
summary:
  A genome-wide search for asthma susceptibility loci in ethnically diverse populations Genetic influences of chromosome 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families: Collaborative Study on the Genetics of Asthma Genome-wide search for asthma susceptibility loci in a founder population A genome-wide search for linkage to asthma: German Asthma Genetics Group Report on the Working Group on Phenotype Approaches Workshop on Genetics of Asthma: methodological approaches Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy Common polymorphisms in the coding part of the IL-4-receptor gene Ileu50Val variant of IL-4a upregulates IgE synthesis and associates with atopic asthma The polymorphisms S530P and Q576R in the interleukin-4 receptor * gene are associated ith atopy and influence signal transduction Effect of allergy associated mutation in human IL-4RA (Q576R) on human IL-4 induced signal transduction This has been further strengthened by the findings in a recent 11,688 Danish twin pairs with use of additive and genetic and nonshared environmental modeling that 73% of asthma susceptibility was genetic and a substantial part of the variation liability of asthma was the result of environmental factors.


id: cord-304140-4l574k3q
author: IJspeert, Hanna
date: 2014-01-11
extension: .txt
mime: text/plain
words: 4789
sentence: 177
flesch: 42
cache: cache/cord-304140-4l574k3q.txt
txt: txt/cord-304140-4l574k3q.txt
title:
  Similar recombination-activating gene (RAG) mutations result in similar immunobiological effects but in different clinical phenotypes

summary:
  The frequency of unique sequences in IGH genes was significantly lower in patients with RAGD than in control subjects (Table III) , which is a reflection of the low numbers of B cells present in PB. B cells have been shown to contribute to the immune dysregulation seen in Rag mouse models.


id: cord-287063-kheek4lx
author: Carroll, Kecia N.
title: Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections
date: 2012-02-14
extension: .txt
mime: text/plain
words: 4761
sentence: 165
flesch: 39
cache: cache/cord-287063-kheek4lx.txt
txt: txt/cord-287063-kheek4lx.txt
summary:
  In summary, infant HRV infections requiring clinical care were more strongly associated with having a mother with atopic asthma than infant RSV infections. Future longitudinal investigations successful at preventing or modifying the host response to infant viral infections will provide insight into the relationship of infant viral infections and early childhood asthma, as will investigations that assess the atopic host and nonatopic host response to select respiratory pathogens.


id: cord-256788-h4iv8crq
author: Sumino, Kaharu
date: 2012-03-27
extension: .txt
mime: text/plain
words: 5044
sentence: 177
flesch: 40
cache: cache/cord-256788-h4iv8crq.txt
txt: txt/cord-256788-h4iv8crq.txt
title:
  Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life

summary:
  key: cord-256788-h4iv8crq authors: Sumino, Kaharu; Tucker, Jennifer; Shahab, Muhammad; Jaffee, Katy F.; Visness, Cynthia M.; Gern, James E.; Bloomberg, Gordon R.; Holtzman, Michael J. title: Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life date: 2012-03-27 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2012.02.033 sha: doc_id: 256788 cord_uid: h4iv8crq BACKGROUND: Viral respiratory tract infections are the leading cause of acute illness during infancy and are closely linked to chronic inflammatory airway diseases later in life. Viral respiratory tract infections are a common cause of early childhood illness.


id: cord-265054-52eqdlef
author: Schaller, Matthew
title: Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response
date: 2006-08-03
extension: .txt
mime: text/plain
words: 5422
sentence: 195
flesch: 32
cache: cache/cord-265054-52eqdlef.txt
txt: txt/cord-265054-52eqdlef.txt
summary:
  By this same theory, it has been demonstrated that chemokine levels produced during respiratory syncytial virus infection determine host responses to later immune stimuli in the lung, with the potential to augment the asthmatic response. A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia Respiratory syncytial virus infection in elderly and high-risk adults The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children Respiratory viruses and exacerbations of asthma in adults Macrophage inflammatory protein-1alpha and RANTES are present in nasal secretions during ongoing upper respiratory tract infection A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus A comparison of cytokine responses in respiratory syncytial virus and influenza A infections in infants Interleukin-6, interleukin-8, interleukin-11, and interferon-gamma levels in nasopharyngeal aspirates from wheezing children with respiratory syncytial virus or influenza A virus infection Chemokines in nasal secretions of normal adults experimentally infected with respiratory syncytial virus Local and systemic cytokine responses during experimental human influenza A virus infection.


id: cord-349754-v6lll1xy
author: Zhu, Zhaozhong
date: 2020-07-18
extension: .txt
mime: text/plain
words: 1777
sentence: 52
flesch: 23
cache: cache/cord-349754-v6lll1xy.txt
txt: txt/cord-349754-v6lll1xy.txt
title:
  Investigating asthma heterogeneity through shared and distinct genetics: insights from genome-wide cross-trait analysis

summary:
  The genome-wide cross-trait analysis features in several analytical aspects: genetic correlation, cross-trait meta-analysis, Mendelian randomization, polygenic risk score and functional analysis. 142 After adequately controlling for population ancestry, genetic correlation would occur only if the 143 germline genetic variant is causal or in linkage disequilibrium (LD) with the causal variant of 144 both traits.


id: cord-323695-jkik03lb
author: Paolo, Gisondi
date: 2020-11-05
extension: .txt
mime: text/plain
words: 1747
sentence: 58
flesch: 36
cache: cache/cord-323695-jkik03lb.txt
txt: txt/cord-323695-jkik03lb.txt
title:
  Incidence rates of hospitalization and death from COVID-19 in patients with psoriasis receiving biological treatment: a Northern Italy experience

summary:
  Despite a great effort has been made in retrieving COVID-19 patients, we acknowledge that there is still a possibility that we have missed important cases. Elevated plasma level of selective cytokines in COVID-19 patients reflect viral load and lung injury Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence.


id: cord-302886-5zjghwkq
author: Ronit, Andreas
title: Compartmental immunophenotyping in COVID-19 ARDS: A case series
date: 2020-10-23
extension: .txt
mime: text/plain
words: 4612
sentence: 181
flesch: 41
cache: cache/cord-302886-5zjghwkq.txt
txt: txt/cord-302886-5zjghwkq.txt
summary:
  regulatory T cells is important for resolution of acute lung injury T helper 17 cells are involved in the local and systemic inflammatory response in community-acquired pneumonia Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy Increased percentage of CD41CD251 regulatory T cells during septic shock is due to the decrease of CD41CD25-lymphocytes Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases Disruption of CTLA-4 expression on peripheral blood CD8 1 T cell enhances anti-tumor efficacy in bladder cancer Expression of lymphocyte activation surface antigens in bronchoalveolar lavage and peripheral blood cells from young healthy subjects Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Temporal changes in cytokine/ chemokine profiles and pulmonary involvement in severe acute respiratory syndrome Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients Heightened innate immune responses in the respiratory tract of COVID-19 patients Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung Prevention of the cytokine storm in COVID-19 Thus, the marked PD1 upregulation found not only in patient blood CD8 T cells but also in CD4 T cells likely indicates a more general pronounced exhaustion in patients with COVID-19.


id: cord-314640-vik5rgnq
author: Ohkubo, Kimihiro
title: Aminopeptidase activity in human nasal mucosa()()()()
date: 2005-11-02
extension: .txt
mime: text/plain
words: 4337
sentence: 183
flesch: 47
cache: cache/cord-314640-vik5rgnq.txt
txt: txt/cord-314640-vik5rgnq.txt
summary:
  key: cord-314640-vik5rgnq authors: Ohkubo, Kimihiro; Baraniuk, James N.; Hohman, Robert; Merida, Marco; Hersh, Louis B.; Kaliner, Michael A. title: Aminopeptidase activity in human nasal mucosa()()()() date: 2005-11-02 journal: J Allergy Clin Immunol DOI: 10.1016/s0091-6749(98)70013-2 sha: doc_id: 314640 cord_uid: vik5rgnq Background: Aminopeptidases activate bradykinin and degrade many inflammatory peptides. Objective: The objective of this study was to identify the types of aminopeptidase activities in human nasal mucosa.


id: cord-259927-xh9cw9ao
author: Papadopoulos, Nikolaos G.
title: Promising approaches for the treatment and prevention of viral respiratory illnesses
date: 2017-07-21
extension: .txt
mime: text/plain
words: 7351
sentence: 257
flesch: 24
cache: cache/cord-259927-xh9cw9ao.txt
txt: txt/cord-259927-xh9cw9ao.txt
summary:
  A viruses Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies Layer-by-layer nanoparticle vaccines carrying the G protein CX3C motif protect against RSV infection and disease Eleven years of Inflexal V-a virosomal adjuvanted influenza vaccine Human papillomavirus and HPV vaccines: a review AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial M2e-based universal influenza A vaccine Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development Comparison of a novel microcrystalline tyrosine adjuvant with aluminium hydroxide for enhancing vaccination against seasonal influenza Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults Chitosan-a versatile semi-synthetic polymer in biomedical applications Genetic immunization is a simple method for eliciting an immune response Development of an intradermal DNA vaccine delivery strategy to achieve single-dose immunity against respiratory syncytial virus Modified mRNA vaccines protect against Zika virus infection DNA and RNA-based vaccines: principles, progress and prospects Replicon RNA viral vectors as vaccines Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response Efficacy and safety of high-dose influenza vaccine in elderly adults: a systematic review and meta-analysis Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: a systematic review and meta-analysis A systematic review and meta-analysis of cross-reactivity of antibodies induced by oil-in-water emulsion adjuvanted influenza H5N1 virus monovalent vaccines Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A Efficacy and safety of treatment with an anti-m2e monoclonal antibody in experimental human influenza Safety and upper respiratory pharmacokinetics of the hemagglutinin stalk-binding antibody VIS410 support treatment and prophylaxis based on population modeling of seasonal influenza A outbreaks Priming by a novel universal influenza vaccine (Multimeric-001)-a gateway for improving immune response in the elderly population A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial Caparr os-Wanderley W. Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled phase I trial A synthetic influenza virus vaccine induces a cellular immune response that correlates with reduction in symptomatology and virus shedding in a randomized phase Ib live-virus challenge in humans A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP1M1 in adults aged over 50 years A Phase IIA study to assess the safety and efficacy of a new influenza candidate vaccine MVA-NP1M1 in healthy adults-Flu002 Clinical Study Report Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine Back to the future: immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain Safety and immunogenicity of multimeric-001-a novel universal influenza vaccine Implication of respiratory syncytial virus (RSV) F transgene sequence heterogeneity observed in Phase 1 evaluation of MEDI-534, a live attenuated parainfluenza type 3 vectored RSV vaccine Phase-I study MEDI-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children A randomized, blinded, controlled, dose-ranging study of a respiratory syncytial virus recombinant fusion (F) nanoparticle vaccine in healthy women of childbearing age Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial Trivalency of a nanobody specific for the human respiratory syncytial virus fusion glycoprotein drastically enhances virus neutralization and impacts escape mutant selection Efficacy, safety, and pharmacokinetics of a new 10% liquid intravenous immunoglobulin containing high titer neutralizing antibody to RSV and other respiratory viruses in subjects with primary immunodeficiency disease Treatment with novel RSV Ig RI-002 controls viral replication and reduces pulmonary damage in immunocompromised Sigmodon hispidus Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection Highly conserved protective epitopes on influenza B viruses Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses Tackling influenza with broadly neutralizing antibodies Influenza virus vaccine based on the conserved hemagglutinin stalk domain Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies Chimeric hemagglutinin constructs induce broad protection against influenza B virus challenge in the mouse model Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus Influenza vaccine research funded by the European Commission FP7-Health-2013-Innovation-1 project Antibodies to watch in 2017 Protective efficacy and immunogenicity of an adenoviral vector vaccine encoding the codon-optimized F protein of respiratory syncytial virus Immunogenicity of RSV F DNA vaccine in BALB/c Mice RSV fusion (F) protein DNA vaccine provides partial protection against viral infection Chimeric virus-like particles containing a conserved region of the G protein in combination with a single peptide of the M2 protein confer protection against respiratory syncytial virus infection Baculovirus-expressed virus-like particle vaccine in combination with DNA encoding the fusion protein confers protection against respiratory syncytial virus Co-immunization with virus-like particle and DNA vaccines induces protection against respiratory syncytial virus infection and bronchiolitis Respiratory syncytial virus: infection, detection, and new options for prevention and treatment Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F-protein of respiratory syncytial virus Mucosal vaccines against respiratory syncytial virus Prevention of colds by vaccination against a rhinovirus: a report by the scientific committee on common cold vaccines Challenges in developing a cross-serotype rhinovirus vaccine Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses.


id: cord-281566-6v5zfue6
author: Hamilos, Daniel L.
title: Host-microbial interactions in patients with chronic rhinosinusitis
date: 2013-11-28
extension: .txt
mime: text/plain
words: 11737
sentence: 459
flesch: 30
cache: cache/cord-281566-6v5zfue6.txt
txt: txt/cord-281566-6v5zfue6.txt
summary:
  The role of epithelial beta-defensins and cathelicidins in host defense of the lung Human beta-defensins and toll-like receptors in the upper airway Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3 Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin Fungal allergens induce cathelicidin LL-37 expression in chronic rhinosinusitis patients in a nasal explant model Human cathelicidin antimicrobial peptide is up-regulated in the eosinophilic mucus subgroup of chronic rhinosinusitis patients Structure and functions of endotoxin-binding peptides derived from CAP18 The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense PLUNC is a novel airway surfactant protein with anti-biofilm activity PLUNC: a multifunctional surfactant of the airways Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis Expression and clinical significance of PLUNC protein in nasal polyp and chronic sinusitis tissue The new histologic classification of chronic rhinosinusitis Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray Antibody equivalent molecules of the innate immune system: parallels between innate and adaptive immune proteins Upregulation of surfactant protein A in chronic rhinosinusitis Expression and significance of surfactant A in nasal polyps of chronic rhinosinusitis Surfactant protein d expression in chronic rhinosinusitis patients and immune responses in vitro to Aspergillus and Alternaria in a nasal explant model Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood A population-based study of morbidity and mortality in mannose-binding lectin deficiency Increased serum complement component 3 and mannose-binding lectin levels in adult Chinese patients with chronic rhinosinusitis Serum amyloid A is an innate immune opsonin for Gram-negative bacteria Alterations in gene expression of complement components in chronic rhinosinusitis High nitric oxide production in human paranasal sinuses Nitric oxide and the paranasal sinuses Activation of the receptor induces production of NO and increases ciliary beat frequency in sinus epithelial cells.


id: cord-258093-6fn8ei9f
author: Hanania, Nicola A.
date: 2011-08-25
extension: .txt
mime: text/plain
words: 17068
sentence: 711
flesch: 41
cache: cache/cord-258093-6fn8ei9f.txt
txt: txt/cord-258093-6fn8ei9f.txt
title:
  Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop

summary:
  The aging lung Large, longitudinal, and more complete studies to determine the effects of aging on the function of the respiratory system Improved knowledge about lung structure-function relationships in older age using techniques of imaging and measures of lung function not requiring effort (eg, high-resolution computed tomographic scanning and forced oscillation) Improved assessment of lung processes underlying airflow limitation attributable to aging versus COPD or asthma, especially in asthmatic patients who smoke Studies to examine the effects of aging in ethnic groups and the role of gender Epidemiology, effect, diagnosis, and management Determine the true prevalence and cost of asthma in the older population Develop a uniform definition of asthma to be applied to health care records that will distinguish asthma from COPD and mixed asthma/COPD Evaluate evidence-based treatment algorithms for older asthmatic patients, such as those developed by the National Heart, Lung, and Blood Institute and Global Initiative For Asthma guidelines 7 Assess the effect of asthma treatment, including direct medical costs of care, indirect costs of care, and value of treatment in improving quality of life 8, 9 Assess the effect of comorbid conditions, especially COPD and congestive heart failure, on asthma 9 Characterize phenotypes of elderly asthma with regard to responses to therapy and long-term outcomes based on age of onset, duration of disease, and environmental triggers Develop algorithms for electronic medical record systems that are asthma-specific Evaluate effects of current asthma medications in older patients compared with younger patients Identify pharmacogenetic determinants of response to asthma medications in older adults Identify simpler and safer drug delivery systems and schedules for older adults Develop simple methods to differentiate COPD from asthma exacerbations in older adults Understand how environmental or aging-related factors affect epigenetic changes in asthma in older adults Identify differences between older and younger asthmatic patients or between LSA and LOA with regard to inflammation, remodeling, intracellular mechanisms, responses to environmental pollutants, and allergy sensitization and their effects on the metabolism and action of asthma drugs Identify naturally occurring age-related changes in airway cellular patterns Develop animal models of age-related airway inflammation Understand the significance of allergy sensitization associated with asthma in older adults (eg, through larger prospective studies) 97, 124, 128 Patients with LOA start having asthma symptoms for the first time when they are 65 years of age or older (some studies have suggested middle age or older).


id: cord-269776-hj1s3ipp
author: Agostoni, Angelo
date: 2004-09-11
extension: .txt
mime: text/plain
words: 50588
sentence: 2202
flesch: 41
cache: cache/cord-269776-hj1s3ipp.txt
txt: txt/cord-269776-hj1s3ipp.txt
title:
  Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond

summary:
  The plasma kallikrein-kinin system counterbalances the renin-angiotensin system The physiologic basis of assembly and activation of the plasma kallikrein/kinin system Mechanism of enhanced kinin release from high molecular weight kininogen by plasma kallikrein after its exposure to plasmin Detection of active kallikrein in induced blister fluids of hereditary angioedema patients Dose-dependent effects of postmenopausal estrogen and progestin on antithrombin III and factor XII Increased euglobulin fibrinolytic potential in women on oral contraceptives low in oestrogen-levels of extrinsic and intrinsic plasminogen activators, prekallikrein, factor XII, and C1-inactivator Molecular basis of estrogen regulation of Hageman factor XII gene expression Contact factors in plasma from women on oral contraception-significance of factor XI for the measured activity of factor XII Biochemical and molecular pharmacology of kinin receptors Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation Receptors for kinins: from classical pharmacology to molecular biology Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors Regulation of bradykinin B2-receptor expression by oestrogen Coexistence of hereditary angioedema and Turner's syndrome Hereditary angioedema precipitated by estrogen replacement therapy in a menopausal woman Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy Recurrent angioedema: familial and oestrogen-induced Angioedema and oral contraception Recurrent angioedema associated with hypogonadism or anti-androgen therapy Estrogen induction and contact phase activation of human factor XII Enhanced expression of factor XII (Hageman factor) in isolated livers of estrogenand prolactin-treated rats The influence of estrogen and prolactin on Hageman factor (factor XII) titer in ovariectomized and hypophysectomized rats Differential regulation of kininogen gene expression by estrogen and progesterone in vivo The effect of oestrogen dose and progestogen type on haemostatic changes in women taking low dose oral contraceptives Effects of a very low-estrogen oral contraceptive on clotting factors, carbohydrate metabolism and plasma lipids and lipoproteins Contact activation factors in plasma from women using oral contraceptives-increased levels of factor XII, kinin-free high molecular weight kininogen and acetone-activated kallikrein Estrogen-associated thromboembolism Contact factor mediated fibrinolysis is increased by the combined oral contraceptive pill Prospective randomized study of effects of unopposed estrogen replacement therapy on markers of coagulation and inflammation in postmenopausal women Positive impact of hormone replacement therapy on the fibrinolytic system: a long-term randomized controlled study in healthy postmenopausal women Postmenopausal hormone replacement therapy increases coagulation activity and fibrinolysis Effect of long-term hormone replacement therapy on angiotensin-converting enzyme activity and bradykinin in postmenopausal women with essential hypertension and normotensive postmenopausal women Estrogen regulation of angiotensin-converting enzyme mRNA Sex hormones in hereditary angioneurotic oedema The complete drug reference Bethesda: American Society of Health-System Pharmacists DRUGDEXÒ system Hereditary angioedema and oral contraception Effects of methylamine and heparin on a rapid chromogenic assay of C1-esterase inhibitor in plasma Effect of time, temperature and additives on a functional assay of C1 inhibitor Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women Management and diagnostic guidelines for urticaria and angio-oedema Hereditary angioneurotic oedema in three families: symptomatic heterogeneity, complement analysis and therapeutic trials Hereditary angioneurotic oedema in Finland: clinical, immunological and genealogical studies Hereditary angioedema due to deficit of C1 esterase inhibitor Hereditary angioneurotic edema: a clinical survey C1-INH defect as an example of deficiency disease Hereditary angioedema: danazol therapy in a 5-year-old child Hereditary angioneurotic oedema: current management in pregnancy A multicentre evaluation of the diagnostic efficiency of serological investigations for C1 inhibitor deficiency Inherited and acquired deficiencies of C1 esterase inhibitor in humans C3 is activated in hereditary angioedema, and C1/C1-inhibitor complexes rise during physical stress in untreated patients Contact system in healthy term newborns: reference values in cord blood Application of a monoclonal antibody against a neoepitope on activated C4 in an ELISA for the quantification of complement activation via the classical pathway C1 inhibitor and diagnosis of hereditary angioedema in newborns Complement components in 100 newborns and their mothers determined by electroimmunoassay Angioedema: a review on the acquired, allergic or non-allergic, and the hereditary forms Serum complement levels in infancy: age related changes Influence of age and sex on serum complement components in children Development of the human coagulation system in the full-term infant Plasma protease inhibitors in premature infants: influence of gestational age, postnatal age, and health status Serum complement profiles in infants and children Misdiagnosis of hereditary angio-oedema type 1 and type 2 Acute consumption of C1 inhibitor in a patient with acquired C1-inhibitor deficiency syndrome Normal complement C4 values do not exclude hereditary angioedema Hereditary angioneurotic oedema Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor C1 INH concentrate in the therapy of hereditary angioedema C1-esterase inhibitor transfusions in patients with hereditary angioedema Replacement therapy in hereditary angioedema: successful treatment of two patients with fresh frozen plasma C1-inhibitor deficiency and angioedema Treatment of hereditary angioedema Letter: anaphylactic reaction to aprotinin DX-88 and HAE: a developmental perspective The synthetic Kunitz domain protein DX-88 to treat angioedema in patients with hereditary angioedema Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma Jerini announces positive phase II study results with Icatibant for the treatment of Hereditary Angioedema A phase I study of recombinant human C1-INH in asymptomatic patients with hereditary angioedema-HAE Pharming features clinical results of C1 inhibitor at investigator meeting [press release Treatment of hereditary angioedema with danazol: reversal of clinical and biochemical abnormalities Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives Side effects of long-term prophylaxis with attenuated androgens in hereditary angioedema: comparison of treated and untreated patients The long-term safety of danazol in women with hereditary angioedema Long-term treatment of hereditary angioedema with attenuated androgens: a survey of a 13-year experience Danazol therapy: an unusual aetiology of hepatocellular carcinoma Hepatocellular adenomas in patients taking danazol for hereditary angio-oedema Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema A case of hereditary angioneurotic oedema, successfully treated with epsilonaminocaproic acid: studies on C'1 esterase inhibitor, C'1 activation, plasminogen level and histamine metabolism Long-term prophylaxis with C1-inhibitor (C1 INH) concentrate in patients with recurrent angioedema caused by hereditary and acquired C1-inhibitor deficiency Pharmacokinetic parameters of C1-inhibitor concentrate in 40 patients with hereditary angio-oedema (HAE)-a prospective study Acute airway obstruction following tooth extraction in hereditary angioedema Oral manifestations and dental management of patients with hereditary angioedema Hereditary angioedema: report of case Prophylactic use of epsilon aminocaproic acid for oral surgery in a patient with hereditary angioneurotic edema Tranexamic acid: preoperative prophylactic therapy for patients with hereditary angioneurotic edema Intravenous tranexamic acid in the management of hereditary angio-oedema Potentially fatal hereditary angioedema: a review and case report The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures Successful off-pump coronary artery bypass graft surgery in a patient with hereditary angioedema Preoperative prophylaxis for C1 esterase-inhibitor deficiency in patients undergoing oral surgery: a report of three cases Hereditary angioedema: uncomplicated maxillofacial surgery using short-term C1 inhibitor replacement therapy C1-esterase inhibitor concentrate prevents upper airway obstruction in hereditary angio-oedema Acquired angioedema as the presenting feature of lymphoproliferative disorders of mature B-lymphocytes Spontaneous regression of acquired C1 esterase inhibitor deficiency associated with splenic marginal zone lymphoma presenting with recurrent angio-oedema Acquired angioedema associated with rectal carcinoma and its response to danazol therapy: acquired angioedema treated with danazol Activation of the contact system and fibrinolysis in autoimmune acquired angioedema: a rationale for prophylactic use of tranexamic acid Angioneurotic edema with acquired C1-inhibitor deficiency and autoantibody to C1-inhibitor: response to plasmapheresis and cytotoxic therapy Purity, activity, and virus safety of a pasteurized antithrombin concentrate A factor VIII concentrate, highly purified and heated in solution Virus-safe plasma proteins: elimination of viruses of risk by the manufacturing procedure Inactivation of hepatitis A virus by pasteurization and elimination of picornaviruses during manufacture of factor VIII concentrate Absence of anti-human immunodeficiency virus types 1 and 2 seroconversion after the treatment of hemophilia A or von Willebrand's disease with pasteurized factor VIII concentrate Absence of hepatitis after treatment with a pasteurized factor VIII concentrate in patients with hemophilia and no previous transfusions Effectiveness of alternative treatments for reducing potential viral contaminants from plasma-derived products Inactivation of parvovirus B19 during pasteurization of human serum albumin A novel coronavirus associated with severe acute respiratory syndrome Virus safety of pasteurized clotting factor concentrates: an eleven year follow up Hepatitis C and pasteurized C1-inhibitor concentrate Prospective virus safety follow-up after therapy with a pasteurized C1-inhibitor concentrate Prophylactic treatment with pasteurised C1 inhibitor in herditary angioedema (HAE)-a prospective 32 months follow up Prospective follow up of clinical manifestation and therapy in children with hereditary angioedema (HAE) High-titer screening PCR: a successful strategy for reducing the parvovirus B19 load in plasma pools for fractionation Prospective audit of adverse reactions occurring in 459 primary antibody-deficient patients receiving intravenous immunoglobulin State of care for hemophilia in pediatric patients Hereditary angioedema Treatment of acute attacks of hereditary angioedema with C1-inhibitor concentrate Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency Proteolytic inactivation of plasma C1-inhibitor in sepsis Expression of active human C1 inhibitor serpin domain in Escherichia coli N-and O-glycans of recombinant human C1 Inhibitor expressed in the milk of transgenic rabbits Production of complex human glycoproteins in yeast Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils The effect of danazol in the treatment of chronic cystic mastitis Danazol-induced pseudomenopause in the management of endometriosis Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women Cortical and trabecular bone mineral content in women with endometriosis: effect of gonadotropin-releasing hormone agonist and danazol A comparison of the skeletal effects of goserelin and danazol in premenopausal women with endometriosis Evidence of similar increases in bone turnover during nafarelin and danazol use in women with endometriosis Amino acids mutated in HAE patients are depicted in yellow ball-and-stick.


