item: #1 of 58 id: cord-011426-jn29kica author: Portero de la Cruz, Silvia title: A Multicenter Study into Burnout, Perceived Stress, Job Satisfaction, Coping Strategies, and General Health among Emergency Department Nursing Staff date: 2020-04-02 words: 4761 flesch: 47 summary: Workplace Stress: A Collective Challenge Patient satisfaction, stress and burnout in nursing personnel in emergency departments: A cross-sectional study Global trends in occupational medicine: Results of the International Occupational Medicine Society Collaborative Survey Conflict management style, supportive work environments and the experience of work stress in emergency nurses Occupational stress and coping strategies among emergency department nurses of China Physical, psychological and occupational consequences of job burnout: A systematic review of prospective studies Work related stress, burnout, job satisfaction and general health of nurses: A follow-up study Job satisfaction among hospital nurses: A literature review The nature and causes of job satisfaction Job satisfaction among emergency department staff Factors affecting nurses' job satisfaction in rural and urban acute care settings: A PRISMA systematic review Relationships between coping strategies and burnout symptoms: The effects of confrontation and avoidance coping in response to workplace incivility Stress and burnout syndrome and their associations with coping and job satisfaction in critical care nurses: A literature review A review and an integration of research on job burnout The measurement of burnout revisited An investigation of factors supporting the psychological health of staff in a UK emergency department Guilt, shame and need for a container: A study of post-traumatic stress among ambulance personnel Comparing burnout across emergency physicians, nurses, technicians, and health information technicians working for the same organization An analysis of the relationship between burnout, socio-demographic and workplace factors and job satisfaction among emergency department health professionals Factors associated with burnout during emergency medicine residency Factors influencing emergency nurses' burnout during an outbreak of Middle East respiratory syndrome coronavirus in Korea Burnout among female emergency medicine physicians: A nationwide study Review article: Burnout in emergency medicine physicians Burnout, job satisfaction and depression in the healthcare personnel who work in the emergency department Burnout, depression, life and job satisfaction among Canadian emergency physicians Burnout and satisfaction with work-life balance among US physicians relative to the general US population Sense of meaning as a predictor of burnout in emergency physicians in Israel: A national survey Burnout and its correlates in emergency physicians: Four years' experience with a wellness booth Systematic review of the association between physical activity and burnout Assertiveness and its relationship to emotional problems and burnout in healthcare workers Occupational burnout levels in emergency medicine-a stage 2 nationwide study and analysis Aspectos epidemiológicos del síndrome de burnout en personal sanitario The relationship between psychosocial job stress and burnout in emergency departments: An exploratory study This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license We thank the managers of the participating hospitals for their help in data collection, and the professionals who collaborated in the study. keywords: analysis; anxiety; avoidance; burnout; coping; data; department; dimensions; dysfunction; eds; emergency; exercise; experience; factors; general; health; high; higher; items; job; job satisfaction; level; low; nurses; nursing; occupational; personnel; physical; physicians; points; population; prevalence; problem; professionals; psychological; questionnaire; related; relationship; research; results; review; satisfaction; scale; scores; significant; social; staff; strategies; stress; studies; study; syndrome; use; variables; work; years cache: cord-011426-jn29kica.txt plain text: cord-011426-jn29kica.txt item: #2 of 58 id: cord-011965-n0re0u5u author: Bibbò, Stefano title: Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor date: 2020-06-05 words: 6031 flesch: 23 summary: Syndrome-A Systematic Review Long-term Outcomes of Fecal Microbiota Transplantation in Patients With Cirrhosis Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo-Controlled Trial A 5-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: A randomized clinical trial Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study Challenges in fecal donor selection and screening for fecal microbiota transplantation: A review 512-Donor Health Screening for Fecal Microbiota Transplantation: Prospective Evaluation of 15,317 Candidate Donors Treatment approaches including fecal microbiota transplantation for recurrent Clostridium difficile infection (RCDI) among infectious disease physicians Seeking safe stool: Canada needs a universal donor model Age-related changes in gut microbiota composition from newborn to centenarian: A cross-sectional study Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice Healthcare personnel intestinal colonization with multidrug-resistant organisms Advanced PCR-based molecular diagnosis of gastrointestinal infections: Challenges and opportunities Gastrointestinal Carriage of Vancomycin-Resistant Enterococci and Carbapenem-Resistant Gram-Negative Bacteria in an Endemic Setting: Prevalence, Risk Factors, and Outcomes. Front Natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE): A systematic review Screening of faecal microbiota transplant donors during the COVID-19 outbreak: Suggestions for urgent updates from an international expert panel Systematic Review: Adverse Events of Fecal Microbiota Transplantation Transmission and clearance of potential procarcinogenic bacteria during fecal microbiota transplantation for recurrent Clostridioides difficile Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant The taxonomic composition of the donor intestinal microbiota is a major factor influencing the efficacy of faecal microbiota transplantation in therapy refractory ulcerative colitis The Super-Donor Phenomenon in Solid organ transplantation in the 21(st) century Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and Diversity as Measures of Donor Quality Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection Faecal microbiota transplantation and bacteriotherapy for recurrent Clostridium difficile infection: A retrospective evaluation of 31 patients. keywords: abundance; antibiotic; approach; bacteria; bowel; case; cdi; chronic; clinical; clostridium; colitis; composition; conditions; date; difficile; difficile infection; disease; disorders; diversity; donor; dysbiosis; effective; efficacy; evidence; factors; fecal; fecal microbiota; feces; fmt; gastrointestinal; gut; gut microbiota; healthy; high; ibd; ibs; ideal; indications; infection; inflammatory; insulin; interview; intestinal; material; metabolic; microbial; microbiota; microbiota transplantation; number; optimal; particular; pathogens; patients; potential; practice; recent; recipients; recurrent; related; resistant; response; results; review; risk; role; screening; selection; sensitivity; society; species; specific; stool; studies; study; success; syndrome; systematic; tests; therapy; transfer; transplantation; treatment; trial; ulcerative; use; vancomycin; years cache: cord-011965-n0re0u5u.txt plain text: cord-011965-n0re0u5u.txt item: #3 of 58 id: cord-013457-rqon1adg author: De Cannière, Hélène title: Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study date: 2020-09-29 words: 7370 flesch: 38 summary: Health-related quality of life (HRQoL) assessments were carried out using the Short Form-36 (SF-36) questionnaire and the Minnesota Living with Heart Failure Questionnaire (MLHFQ) at baseline and end-of-study, both validated in CR patients. Although both their mental and physical status improve, CR patients still feel different when compared to healthy subjects after following a CR program. keywords: 6mwd; 6mwts; analysis; association; baseline; capacity; cardiac; cardiac rehabilitation; cardiology; cardiovascular; center; change; clinical; consecutive; cpet; cr program; current; data; decrease; difference; disease; distance; effects; end; european; exercise; failure; follow; functional; groups; heart; home; improvement; increase; information; level; mean; measurements; meta; min; outcome; patients; population; prevention; program; progression; protocol; rate; referral; rehabilitation; rehabilitation program; related; research; results; secondary; short; significant; studies; study; term; test; time; training; walk cache: cord-013457-rqon1adg.txt plain text: cord-013457-rqon1adg.txt item: #4 of 58 id: cord-252687-7084pfqm author: Szelenberger, Rafal title: Ischemic Stroke among the Symptoms Caused by the COVID-19 Infection date: 2020-08-19 words: 7350 flesch: 34 summary: Despite the available clinical studies evaluating the potential role of hemostatis biomarkers (i.e., von Willebrand factor (vWF), P-selectin, fibrinogen, thrombomodulin, tissue factor, d-dimer, etc.) in ischemic stroke patients, the value of studied biomarkers is still unproven and requires further investigation [26] . Ischemic stroke patients mostly received thrombolytic therapy. keywords: accumulation; ace2; activation; acute; adhesion; angiotensin; artery; augmented; blood; body; brain; cascade; causes; cells; cerebral; characteristics; chemokines; clinical; coagulation; complications; concentration; coronavirus; cov-2; covid-19; covid-19 patients; cytokines; damage; damps; death; development; dimer; disease; disorders; drug; dysfunction; effect; endothelium; factors; fibrinogen; flow; formation; health; host; human; hypertension; immune; increase; infected; infection; inflammation; inflammatory; injury; ischemic; ischemic stroke; left; leukocytes; levels; like; macrophages; man; medical; migration; mitochondria; molecules; monocytes; neurological; neuronal; neutrophils; new; number; old; ongoing; oxygen; pandemic; pathogenesis; patients; platelets; potential; pro; production; protein; reactive; release; respiratory; response; responsible; right; risk; role; ros; sars; serum; severe; stroke; studies; study; symptoms; syndrome; system; thromboembolic; thrombosis; time; tissue; treatment; vascular; vessel; viral; year cache: cord-252687-7084pfqm.txt plain text: cord-252687-7084pfqm.txt item: #5 of 58 id: cord-252902-qtfx49qp author: Scott, Jodie title: Creating Healthy Change in the Preconception Period for Women with Overweight or Obesity: A Qualitative Study Using the Information–Motivation–Behavioural Skills Model date: 2020-10-19 words: 8756 flesch: 46 summary: Many women spoke of being too exhausted to cook and often relied heavily on processed foods or take-away, while half of the women reported cooking from scratch most of the time. Many women attributed their excess weight to unhealthy behavioural patterns and felt a responsibility, whether trying to conceive or not, for managing their weight and health. . . . keywords: able; activity; advice; analysis; approach; attitudes; authors; baby; barriers; behavioural; beliefs; benefits; bmi; care; challenges; change; children; choices; class; constructs; control; data; decisions; development; diet; eating; efficacy; exercise; experiences; factors; family; finding; food; future; good; greater; habits; half; health; healthier; high; iii; imb; impact; individual; information; intervention; interview; knowledge; lifestyle; loss; making; management; maternal; mental; model; motivation; need; nutrition; obese; obesity; options; outcomes; overweight; participants; partners; personal; perspectives; physical; poor; potential; preconception; pregnancy; previous; process; psychological; qualitative; questions; research; review; risks; self; significant; skills; social; strategies; study; support; systematic; themes; time; understanding; weight; women cache: cord-252902-qtfx49qp.txt plain text: cord-252902-qtfx49qp.txt item: #6 of 58 id: cord-254148-wc762p6v author: Prell, Tino title: Recommendations for Standards of Network Care for Patients with Parkinson’s Disease in Germany date: 2020-05-13 words: 5351 flesch: 37 summary: In the meantime, in Germany, several university clinics with a PD focus have established this or a similar PD day clinic concept to close the gap in PD care that have been found to be a transnational issue [26] [27] [28] . Rural location, nursing home residence, and the presence of physical or cognitive impairment are common reasons for limited access to specialized PD health care keywords: abbvie; access; activities; advanced; approach; available; bayer; bial; care; caregivers; clinical; costs; course; criteria; current; desitin; deutschland; development; diagnosis; different; digital; disease; disorder; dysphagia; early; effects; evidence; functional; germany; gmbh; group; health; health care; home; honoraria; individual; information; inpatient; integrated; issues; knowledge; life; limited; management; medical; motor; movement; network; neurologists; nurse; nursing; occupational; options; outpatient; pain; palliative; parkinson; patients; performance; pharma; physiotherapy; quality; recommendations; research; results; self; society; specialists; specialized; specific; standards; structures; support; symptoms; telemedicine; therapists; therapy; treatment; ucb; working; zambon cache: cord-254148-wc762p6v.txt plain text: cord-254148-wc762p6v.txt item: #7 of 58 id: cord-262693-z9dolxky author: Nishiura, Hiroshi title: Initial Cluster of Novel Coronavirus (2019-nCoV) Infections in Wuhan, China Is Consistent with Substantial Human-to-Human Transmission date: 2020-02-11 words: 1458 flesch: 36 summary: The clinical summary of the earliest cases of 2019 novel coronavirus (2019-nCoV) infections in Wuhan, China was recently published [1] , showing the majority of cases were exposed to the Huanan seafood market, which also had wild animals, suggesting the possibility of zoonotic transmission in the market. First, Figure 1A shows the epidemic curve of cases in Wuhan, distinguishing case generations by color. keywords: cases; coronavirus; curve; epidemic; exposure; generation; human; human transmission; market; ncov; novel; transmission; wuhan; zoonotic cache: cord-262693-z9dolxky.txt plain text: cord-262693-z9dolxky.txt item: #8 of 58 id: cord-262996-zxn86z6k author: Störmann, Philipp title: Characteristics and Injury Patterns in Electric-Scooter Related Accidents—A Prospective Two-Center Report from Germany date: 2020-05-22 words: 3301 flesch: 51 summary: Bringing High-Energy Trauma to a Wider Audience Impact of e-scooter injuries on Emergency Department imaging Electric Scooter Injury in Southern California Trauma Centers The Integration of Electric Scooters: Useful Technology or Public Health Problem? Are electric scooters promoted on social media with safety in mind? Likewise, worldwide data on injury patterns related to the use of E-scooters are sparse, mainly due to the short time period since their introduction to the public. keywords: accidents; brain; care; cases; city; data; days; department; electric; emergency; extremities; fractures; germany; head; helmet; high; hospital; injuries; injury; intensive; introduction; mean; patients; patterns; period; public; rate; related; scooter; short; study; surgical; time; total; transport; trauma; traumatic; treatment; use cache: cord-262996-zxn86z6k.txt plain text: cord-262996-zxn86z6k.txt item: #9 of 58 id: cord-264355-9quf59td author: Jung, Sung-mok title: Epidemiological Identification of A Novel Pathogen in Real Time: Analysis of the Atypical Pneumonia Outbreak in Wuhan, China, 2019–2020 date: 2020-02-27 words: 4224 flesch: 34 summary: = Pr(observed characteristics pathogen j)q j Disease X was inferred to be very likely on all dates from 31 December 2019 onwards-the date on which descriptions of outbreak characteristics began to emerge. keywords: analysis; atypical; available; candidate; candidate pathogen; cases; causative; characteristics; china; coronavirus; current; december; different; disease; disease x; distance; euclidean; exposure; hamming; human; information; january; laboratory; market; novel; observed; ongoing; ongoing outbreak; outbreak; pathogen; pneumonia; probability; real; table; time; virological; wet; wuhan cache: cord-264355-9quf59td.txt plain text: cord-264355-9quf59td.txt item: #10 of 58 id: cord-264616-l8bv5t3o author: Zhao, Shi title: Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak date: 2020-02-01 words: 2940 flesch: 57 summary: The cumulative number of reported cases slowly increased to cumulative 41 cases by 1 January 2020, and rapidly increased after 16 January 2020. The reporting rate is the ratio of reported cases over the number of seropositive individuals. keywords: cases; china; coronavirus; cumulative; data; days; december; early; exponential; figure; fitting; growth; january; likely; mers; ncov; novel; number; outbreak; pneumonia; rate; reporting; respiratory; results; sars; syndrome; time; unreported; wuhan cache: cord-264616-l8bv5t3o.txt plain text: cord-264616-l8bv5t3o.txt item: #11 of 58 id: cord-267933-rg1yus8g author: Sbeit, Wisam title: Long-Term Safety of Endoscopic Biliary Stents for Cholangitis Complicating Choledocholithiasis: A Multi-Center Study date: 2020-09-12 words: 3584 flesch: 39 summary: Previous studies have reported cholangitis to be the most common long-term complication of biliary stent in the elderly approaching 40% of patients, and 16% of patients died because of biliary-related causes [16] . In our study we used two types of biliary stents, mostly plastic stents (Cotton-Huibregtse stents 10 Fr, 7 cm of Cook medical) and metallic stents (10-mm, 6 cm Wallflex of Boston Scientific). keywords: acute; bile; biliary; cases; chi; cholangitis; choledocholithiasis; colic; common; complications; duct; elderly; endoscopic; ercp; extraction; follow; group; high; insertion; long; metallic; migration; months; overall; pancreatitis; patients; period; plastic; rate; related; replacement; risk; secondary; square; stent; stenting; stones; studies; study; term; treatment cache: cord-267933-rg1yus8g.txt plain text: cord-267933-rg1yus8g.txt item: #12 of 58 id: cord-273351-vq3budip author: Farré, Núria title: Prolonged QT Interval in SARS-CoV-2 Infection: Prevalence and Prognosis date: 2020-08-21 words: 4373 flesch: 45 summary: As expected from previous research, age and comorbidities were associated with prolonged QTc interval and worse prognosis [23] The majority of studies have focused on QTc interval and risk of arrhythmias, especially in the setting of hydroxychloroquine treatment. keywords: admission; azithromycin; baseline; cardiovascular; cause; clinical; comorbidities; coronavirus; covid-19; cut; day; days; death; disease; ecg; heart; higher; hospitalization; hydroxychloroquine; infection; inflammatory; interval; model; mortality; patients; presence; prognosis; prolongation; prolonged; prolonged qtc; qtc; results; risk; sars; severe; similar; studies; study; test; treatment; use; variables; ventricular cache: cord-273351-vq3budip.txt plain text: cord-273351-vq3budip.txt item: #13 of 58 id: cord-273567-8fp3a9h8 author: Zipprich, Hannah M. title: Knowledge, Attitudes, Practices, and Burden During the COVID-19 Pandemic in People with Parkinson’s Disease in Germany date: 2020-05-29 words: 5377 flesch: 51 summary: Patients with limited knowledge were older (mean age, 74.4 years; SD = 7.2) than patients with good knowledge (mean age, 70.0 years; SD = 8.5) (p = 0.03). Patients who felt that they were very well informed about COVID-19 were more likely to search actively for further information (p = 0.03) than patients who felt that they were not sufficiently informed about COVID-19; in contrast, none of the five patients who felt that they were poorly informed about COVID-19 actively searched for information. keywords: additional; adherence; age; analysis; answers; attitudes; behavior; contact; coronavirus; covid-19; current; data; disease; function; home; iii; information; informed; institute; kap; knowledge; koch; level; majority; mds; means; measures; older; pandemic; parkinson; patients; people; preventive; public; questions; relatives; reported; restrictions; robert; sams; score; situation; social; study; telephone; test; updrs; virus; years; younger cache: cord-273567-8fp3a9h8.txt plain text: cord-273567-8fp3a9h8.txt item: #14 of 58 id: cord-274563-jimw6skv author: Fiumara, Agata title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 words: 3526 flesch: 45 summary: Although no statistically significant difference was found compared to controls, we felt that the reactions were qualitatively different, underlining the fragility and isolation of such patients. key: cord-274563-jimw6skv authors: Fiumara, Agata; Lanzafame, Giuseppina; Arena, Alessia; Sapuppo, Annamaria; Raudino, Federica; Praticò, Andrea; Pavone, Piero; Barone, Rita title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 journal: J Clin Med DOI: 10.3390/jcm9092716 sha: doc_id: 274563 cord_uid: jimw6skv Background: Lysosomal storage disorders (LSDs) are rare, chronic, progressive multisystem diseases implying severe medical issues and psychological burden. keywords: behavior; changes; chronic; control; control group; covid-19; daily; data; differences; different; disease; disorders; emergency; ert; family; fear; feeling; future; group; home; hospital; interview; isolation; life; lsds; lysosomal; need; negative; normal; pandemic; patients; people; positive; profound; psychological; rare; relationships; significant; social; study; subjects; therapy; treatment; uncertainty cache: cord-274563-jimw6skv.txt plain text: cord-274563-jimw6skv.txt item: #15 of 58 id: cord-280111-6hiuzkvz author: Maspero, Cinzia title: Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date: 2020-06-17 words: 6917 flesch: 41 summary: Indeed, an application for smartphones that allows remote monitoring of orthodontic patients using an algorithm of artificial intelligence, has recently been developed. The Italian Society of Orthodontics (SIDO) has recently published the recommended guidelines on the management of orthodontic patients during the COVID-19 outbreak. keywords: aligners; application; appointments; approach; articles; assessment; authors; available; benefits; bias; cases; china; clinical; communication; control; coronavirus; covid-19; criteria; data; dental; digital; distance; effective; efficacy; emergencies; evidence; follow; future; healthcare; help; high; infection; information; intraoral; limited; literature; long; management; methods; mixed; mmat; monitoring; need; new; non; number; office; orthodontic; outcomes; pandemic; papers; patients; pneumonia; positive; possible; practice; problems; quality; rapid; records; remote; research; results; review; risk; score; services; software; studies; study; systematic; table; taking; technologies; technology; teleassistance; teledentistry; telemedicine; teleorthodontics; time; tool; traditional; treatment; unnecessary; use; visits; world cache: cord-280111-6hiuzkvz.txt plain text: cord-280111-6hiuzkvz.txt item: #16 of 58 id: cord-281039-a7q5nzwn author: Rodilla, Enrique title: Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 date: 2020-09-28 words: 4808 flesch: 41 summary: Second, previous treatment with ACEIs/ARBs in hypertensive patients was not associated with a higher risk of all-cause mortality in hypertensive hospitalized COVID-19 patients compared to other antihypertensive drugs. Furthermore, the causal role of age in explaining coronary heart disease and stroke increases in parallel with age [17] . Treatment of HT with renin-angiotensin-aldosterone system (RAAS) inhibitors might have a beneficial effect on COVID-19 patients. keywords: ace2; aceis; admission; age; analysis; angiotensin; antihypertensive; arbs; association; atrial; baseline; blockers; cardiovascular; cause; charlson; chronic; clinical; comorbidities; comorbidity; cov-2; covid-19; cvd; data; death; disease; drugs; endpoint; factors; fibrillation; group; higher; hospital; hospitalization; hypertension; increase; independent; index; medical; mortality; non; normotensive; outcomes; patients; population; prevalence; previous; receptor; registry; results; risk; role; sars; semi; severity; significant; spanish; studies; study; subjects; survival; table; treatment; variables cache: cord-281039-a7q5nzwn.txt plain text: cord-281039-a7q5nzwn.txt item: #17 of 58 id: cord-282384-qbcqbhk4 author: Savastano, Alfonso title: Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients date: 2020-09-08 words: 3745 flesch: 39 summary: According to our results, post-COVID-19 patients have a lower RPCP PD and a normal RPCP FI compared to the general population. According to our results, post-COVID-19 patients have a lower RPCP PD and a normal RPCP FI compared to the general population. keywords: age; analysis; angiography; antiplatelet; arterial; autoimmune; average; capillary; choroidal; coherence; coronavirus; covid-19; covid-19 group; damage; density; diabetes; difference; disease; early; endothelial; eye; figure; flow; group; healthy; hypertension; impairment; index; infection; inflammatory; iop; lopinavir; lower; lower rpcp; mean; myopia; oct; optical; patients; perfusion; peripapillary; post; potential; prevalence; radial; results; retinal; ritonavir; rnfl; rpcp; sars; severe; significant; study; systemic; table; therapy; thickness; tomography; variables cache: cord-282384-qbcqbhk4.txt plain text: cord-282384-qbcqbhk4.txt item: #18 of 58 id: cord-283407-3zb6ufum author: Ciuti, Gastone title: Frontiers of Robotic Colonoscopy: A Comprehensive Review of Robotic Colonoscopes and Technologies date: 2020-05-31 words: 15413 flesch: 34 summary: In vitro tests and clinical trial Endotics system vs colonoscopy for the detection of polyps Use of robotic colonoscopy in patients with previous incomplete colonoscopy Accuracy of magnetically controlled capsule endoscopy, compared with conventional gastroscopy, in detection of gastric diseases Capsule endoscopy: From current achievements to open challenges Frontiers of robotic endoscopic capsules: A review The flexible caterpillar based robotic colonoscope actuated by an external motor through a flexible shaft An elastic caterpillar-based self-propelled robotic colonoscope with high safety and mobility A simple and reliable reel mechanism-based robotic colonoscope for high mobility A reel mechanism-based robotic colonoscope with high safety and maneuverability Surgical evaluation of a novel tethered robotic capsule endoscope using micro-patterned treads Soft material adhesion characterization for in vivo locomotion of robotic capsule endoscopes: Experimental and modeling results Novel optimization-based design and surgical evaluation of a treaded robotic capsule colonoscope Design, modeling and control of a SMA-actuated biomimetic robot with novel functional skin Full-driving soft robotic colonoscope in compliant colon tissue A novel robotic meshworm with segment-bending anchoring for colonoscopy Design and preliminary evaluation of a self-steering, pneumatically driven colonoscopy robot A soft pneumatic inchworm double balloon (SPID) for colonoscopy Beer-Sheva, Israel) Magnetically driven medical devices: A review Available online: www.vector-project.com (accessed on Robotic magnetic steering and locomotion of capsule endoscope for diagnostic and surgical endoluminal procedures Robotic versus manual control in magnetic steering of an endoscopic capsule Experimental assessment of a novel robotically-driven endoscopic capsule compared to traditional colonoscopy Magnetic air capsule robotic system: Proof of concept of a novel approach for painless colonoscopy Frictional resistance model for tissue-capsule endoscope sliding contact in the gastrointestinal tract Magnetically-driven medical robots: An analytical magnetic model for endoscopic capsules design A discrete-time localization method for capsule endoscopy based on on-board magnetic sensing Enhanced real-time pose estimation for closed-loop robotic manipulation of magnetically actuated capsule endoscopes A comparative evaluation of control interfaces for a robotic-aided endoscopic capsule platform Sensitivity ellipsoids for force control of magnetic robots with localization uncertainty Adaptive dynamic control for magnetically actuated medical robots Autonomously controlled magnetic flexible endoscope for colon exploration Intelligent magnetic manipulation for gastrointestinal ultrasound Available online: www.endoo-project.eu (accessed on An innovative robotic platform for magnetically-driven painless colonoscopy Fully convolutional neural networks for polyp segmentation in colonoscopy Towards a computed-aided diagnosis system in colonoscopy: Automatic polyp segmentation using convolution neural networks Deep endoscopic visual measurements A structured light laser probe for gastrointestinal polyp size measurement: A preliminary comparative study A new concept for magnetic capsule colonoscopy based on an electromagnetic system regular paper Electromagnetic control system for capsule navigation: Novel concept for magnetic capsule maneuvering and preliminary study Available online: www.supcam.eu (accessed on Retrograde colon capsule endoscopy with the self-propelling capsule endoscope: The first human trial (with videos) Single actuator wave-like robot (SAW): Design, modeling, and experiments A soft robot that navigates its environment through growth Design of a soft catheter for low-force and constrained surgery Magnetic continuum device with variable stiffness for minimally invasive surgery Robotics in the gut Magnetically actuated soft capsule endoscope for fine-needle aspiration biopsy In addition, the senior authors would like to thank the Beijing Advanced Innovation Center for Intelligent Robots and Systems (BAICIRS-Beijing, China) and its RoboCaps team for the scientific collaboration in the field of robotic capsule colonoscopy. keywords: actuation; adr; air; analysis; anus; applications; artificial; assisted; authors; autonomous; available; average; backward; balloon; bending; camera; cancer; capsule; cecal; channel; cir; cit; clinical; colonic; colonoscopy; colorectal; computer; control; conventional; cost; current; data; deep; depth; design; detection; development; device; diagnosis; diameter; direction; discomfort; disposable; distal; dofs; double; electric; electromagnetic; endoscopic; endoscopists; endotics; et al; evaluation; examination; examples; external; fda; features; field; figure; flexible; force; forward; future; gastrointestinal; group; hand; healthcare; high; higher; human; hydraulic; image; improved; innovative; insertion; insufflation; intelligence; interesting; internal; intubation; invasive; inverted; israel; learning; leds; length; like; limited; locomotion; long; loop; low; ltd; lumen; magnetic; magnetically; market; mechanism; medical; min; motor; mucosa; navigation; need; new; non; novel; overall; pain; patients; permanent; platform; pneumatic; polyps; porcine; possible; potential; practice; preliminary; pressure; procedure; project; propelling; randomized; rate; recent; research; results; review; risk; robotic; robotic capsule; robotic colonoscope; robots; safety; screening; section; segments; self; sensors; shape; single; sleeve; soft; speed; standard; state; steering; study; surgery; surgical; system; techniques; technologies; terms; tests; tethered; therapeutic; time; tip; tissue; tract; training; trial; tube; unit; use; vision; vivo; wall; water; wireless; working cache: cord-283407-3zb6ufum.txt plain text: cord-283407-3zb6ufum.txt item: #19 of 58 id: cord-284301-fg3hk94b author: Umemura, Yutaka title: Hematological Phenotype of COVID-19-Induced Coagulopathy: Far from Typical Sepsis-Induced Coagulopathy date: 2020-09-05 words: 3721 flesch: 34 summary: According to these insights, our results suggested that systemic hypercoagulation was hardly induced by COVID-19 infection, but the risk of local thrombus formation increased in the acute phase of severe COVID-19 pneumonia. COVID-19 patients had moderately high levels of thrombin–antithrombin complex and plasmin-alpha2-plasmin inhibitor complex but normal plasminogen activator inhibitor-1 level. keywords: activity; acute; analysis; antithrombin; ards; biomarkers; clinical; coagulation; coagulopathy; coronavirus; covid-19; covid-19 group; criteria; day; dic; differences; dimer; dysfunction; fdp; fibrinogen; group; hemostatic; higher; incidence; intravascular; isth; level; non; normal; patients; pattern; phenotype; pic; platelet; pneumonia; range; respiratory; sepsis; series; severe; sic; significant; study; syndrome; time cache: cord-284301-fg3hk94b.txt plain text: cord-284301-fg3hk94b.txt item: #20 of 58 id: cord-286298-pn9nwl64 author: Helmy, Yosra A. title: The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control date: 2020-04-24 words: 9320 flesch: 44 summary: The other third of SARS CoV-2 includes four genes (in green) that encode four structural proteins (S, M, E, N), and six accessory genes (in blue) that encode six accessory proteins (orf3a, orf6, orf7a, orf7b, orf8, and orf10). While the SARS-CoV-2 S2 subunit was conserved, the S1 subunit shares an overall 70% identity with those of bat and human SARS-CoV. keywords: 2019; acid; activity; acute; addition; amino; analysis; animals; antiviral; associated; asymptomatic; available; bat; bat sars; bats; binding; cases; cells; chest; china; clinical; close; contact; control; coronavirus; countries; course; cov-2; covid-19; covs; data; days; deaths; detection; diagnosis; disease; droplets; drugs; early; epidemiology; evolution; factors; fecal; figure; future; genes; genome; ggo; global; health; high; host; human; infected; infection; inflammatory; influenza; interferon; isolated; january; japan; like; lopinavir; lung; measures; mers; molecular; ncov; novel; novel coronavirus; number; orf1ab; origin; outbreak; pandemic; patients; pcr; people; period; person; phylogenetic; pneumonia; positive; potential; prevention; protein; public; receptor; recombination; researchers; respiratory; review; risk; ritonavir; rna; role; samples; sars; sequences; severe; single; spike; spread; structural; study; substitutions; symptoms; syndrome; table; time; transmission; treatment; tree; viral; viruses; wuhan; years cache: cord-286298-pn9nwl64.txt plain text: cord-286298-pn9nwl64.txt item: #21 of 58 id: cord-287102-o19uwryp author: Amit, Moran title: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study date: 2020-07-18 words: 4185 flesch: 48 summary: The following mortality rates have been found for Covid-19 patients in the ICU for whom outcome data are available (i.e., excluding patients who were still being treated in the ICU at the time of the report): 61% (Lombardy, Italy [2] ), 78% (New York City, NY, USA [4] ), 79% (Wuhan, China [11] ), 57% (Seattle, WA, USA [12] ), 85% (Washington state, USA [13] ), and 67% (China [3] )) Patients who died prior to ICU admission and patients without outcome data were excluded. keywords: acute; age; analysis; associated; available; care; characteristics; china; clinical; comorbidities; coronavirus; course; cov-2; covid-19; data; days; disease; ecmo; factors; health; icu; ill; iqr; israel; laboratory; length; longer; median; model; mortality; multivariable; novel; number; older; organ; outcomes; patients; presence; range; respiratory; sars; sepsis; significant; stay; study; system; table; therapies; therapy; time; treatment; variables; ventilation; years; younger cache: cord-287102-o19uwryp.txt plain text: cord-287102-o19uwryp.txt item: #22 of 58 id: cord-289034-yl3emjef author: Moro, Loredana title: Mitochondria at the Crossroads of Physiology and Pathology date: 2020-06-24 words: 3794 flesch: 23 summary: Primary mitochondrial diseases develop as a consequence of germline mutations in mtDNA and/or nuclear DNA genes that encode proteins affecting mitochondrial functionality and energy production, including ETC proteins and proteins involved in mtDNA replication, such as POLG. Since then, a range of primary mitochondrial diseases has been described (reviewed in [15] ). keywords: activation; activity; aging; arterial; biogenesis; cancer; cardiovascular; cause; cells; conditions; covid-19; cycle; damage; dehydrogenase; diseases; dysfunction; energy; etc; evidence; fission; fusion; immune; inflammation; inflammatory; key; levels; mechanisms; melatonin; metabolic; miro1; mitochondrial; mitophagy; mtdna; mutations; neurodegenerative; nuclear; oxidative; oxphos; parkinson; pathogenesis; pathological; patients; peripheral; potential; primary; production; proteins; reduced; respiratory; response; role; ros; signaling; stress; studies; system; tca; therapeutic; tissue cache: cord-289034-yl3emjef.txt plain text: cord-289034-yl3emjef.txt item: #23 of 58 id: cord-289219-qjxdggz3 author: Sebio-García, Raquel title: Pulmonary Rehabilitation: Time for an Upgrade date: 2020-08-25 words: 1867 flesch: 25 summary: Since early 1980s, pulmonary rehabilitation has been acknowledged as a comprehensive intervention with hundreds of studies being performed over the past thirty years demonstrating its benefits on multiple outcomes; nevertheless, there are still multiple unresolved challenges, and new ones are currently emerging, with the COVID-19 outbreak now in the spotlight. In this editorial, these issues are summarized and discussed, while presenting some of the latest findings in research and clinical practice, with the ultimate goal of raising awareness of the future of pulmonary rehabilitation in the post COVID-19 era. keywords: access; addition; benefits; capacity; chronic; copd; covid-19; delivery; different; disease; exercise; face; healthcare; home; increase; intervention; life; obstructive; patients; physical; programme; pulmonary; quality; rehabilitation; respiratory; risk; study; term; test; use cache: cord-289219-qjxdggz3.txt plain text: cord-289219-qjxdggz3.txt item: #24 of 58 id: cord-289422-5z012sr6 author: Kuniya, Toshikazu title: Prediction of the Epidemic Peak of Coronavirus Disease in Japan, 2020 date: 2020-03-13 words: 2128 flesch: 59 summary: It's a 'false hope' Coronavirus will Disappear in the Summer like the Flu, WHO Says Report 3: Transmissibility of 2019-nCoV Novel coronavirus 2019-nCoV: Ealry estimation of epidemiological parameters and epidemic predictions Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: Japan Sets up Emergency Measures for Coronavirus Age-Structured Populatin Dynamics in Demography and Epidemiology Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: A statistical analysis of publicly available case data Tracking and predicting COVID-19 epidemic in China mainland Population Estimates Monthly Report Japan's Hokkaido may Have 940 Infected, Researcher Says On the definition and the computation of the basic reproduction ratio R 0 in models for infectious diseases in heterogeneous populations Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission Parameter estimation and uncertainty quantification for an epidemic model The Japan Times. keywords: basic; cases; coronavirus; covid-19; disease; epidemic; figure; infective; intervention; january; japan; number; peak; period; prediction; rate; reproduction; size; time cache: cord-289422-5z012sr6.txt plain text: cord-289422-5z012sr6.txt item: #25 of 58 id: cord-289832-092dtzrd author: Villard, Orianne title: The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study date: 2020-07-21 words: 3950 flesch: 35 summary: In univariate analyses, aldosterone levels at inclusion were significantly higher in patients with severe clinical course (OS ≥ 5) (median (min-max), 304.7 (102.5-1360.1) pmol/L) as compared to those with mild or moderate course (OS ≤ 4) (102.5 (102.5-540.2) pmol/L) (p < 0.01). At inclusion, aldosterone levels were not clearly associated with a specific clinical status (p = 0.61) (Figure 2A) . keywords: 102.5; ace2; acute; admission; aldosterone; aldosterone levels; analysis; ang2; angiotensin; clinical; collection; course; cov-2; covid-19; crp; data; day; disease; figure; findings; groups; higher; hospitalization; inclusion; infection; inflammatory; investigation; laboratory; levels; lung; manuscript; max; mild; moderate; ordinal; os max; patients; plasma; raas; receptor; renin; reviewing; role; sars; scale; severe; severity; status; study; system cache: cord-289832-092dtzrd.txt plain text: cord-289832-092dtzrd.txt item: #26 of 58 id: cord-290135-ax5ck4qw author: Urbano, Nicoletta title: [(99)mTc]Sestamibi SPECT Can Predict Proliferation Index, Angiogenesis, and Vascular Invasion in Parathyroid Patients: A Retrospective Study date: 2020-07-13 words: 3560 flesch: 32 summary: The aim of this study was to evaluate the possible association among sestamibi uptake and the main histopathological characteristics of parathyroid lesions related to aggressiveness such as the proliferation index (Ki67 expression and mitosis), angiogenesis (number of vessels), and vascular invasion in hyperparathyroidism patients. To investigate the possible association between sestamibi uptake and cells proliferation in parathyroid lesions, linear regression analyses were performed ( Figure 2 ). keywords: adenoma; age; analysis; angiogenesis; association; biopsy; breast; cancer; carcinoma; cells; characteristics; data; diagnostic; figure; histological; hyperparathyroidism; imaging; index; invasion; ki67; lesions; linear; mitosis; mtc]sestamibi; negative; number; parathyroid; patients; php; positive; possible; proliferation; regression; scintigraphy; sestamibi; sestamibi uptake; significant; spect; study; surgery; terms; tumors; uptake; vascular; vascular invasion; vessels cache: cord-290135-ax5ck4qw.txt plain text: cord-290135-ax5ck4qw.txt item: #27 of 58 id: cord-290286-3t0roikx author: Arango-Lasprilla, Juan Carlos title: Early Predictors of Employment Status One Year Post Injury in Individuals with Traumatic Brain Injury in Europe date: 2020-06-26 words: 6446 flesch: 42 summary: Traumatic brain injury: Integrated approaches to improve prevention, clinical care, and research Global neurotrauma research challenges and opportunities Estimating the global incidence of traumatic brain injury Modeling of Community Integration Trajectories in the First Five Years after Traumatic Brain Injury Health-related Quality of Life 12 months after severe traumatic brain injury: A prospective nationwide cohort study Long-term employment outcomes following moderate to severe traumatic brain injury: A systematic review and meta-analysis Predictive factors for 1-year outcome of a cohort of patients with severe traumatic brain injury (TBI): Results from the PariS-TBI study Work-related difficulties in patients with traumatic brain injury: A systematic review on predictors and associated factors Racial and Ethnic Disparities in Employment Outcomes for Persons With Traumatic Brain Injury: A Longitudinal Investigation 1-5 Years After Injury Prognostic factors of return to work after traumatic or non-traumatic acquired brain injury Return to work after acquired brain injury: A qualitative study Impact of personal and environmental factors on employment outcome two years after moderate-to-severe traumatic brain injury Psychosocial outcomes 1-7 years after comprehensive milieu-oriented neurorehabilitation: The role of pre-injury status Racial Differences in Employment Outcomes After Traumatic Brain Injury Estrategia de salud de la Unión Europea: Salud pública para las personas europeas Análisis de la eficiencia técnica en los hospitales del Sistema Nacional de Salud español Epidemiology of traumatic brain injuries in Europe: A cross-sectional analysis Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): A Prospective Longitudinal Observational Study Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: A European prospective, multicentre, longitudinal, cohort study Assessment of coma and impaired consciousness. keywords: age; baseline; brain; brain injury; care; center; countries; data; early; employment; employment status; european; evidence; factors; following; gcs; groups; higher; hospital; individuals; injury; injury severity; iss; level; loc; los; lower; majority; mild; model; moderate; months; older; outcome; patients; post; predictors; premorbid; present; previous; probability; problems; prospective; psychiatric; rates; rehabilitation; reported; research; results; return; review; scale; score; severe; severity; status; studies; study; support; systematic; tbi; time; traumatic; traumatic brain; unemployed; variables; work; working; year; year post cache: cord-290286-3t0roikx.txt plain text: cord-290286-3t0roikx.txt item: #28 of 58 id: cord-292341-uo54ghf3 author: Cocconcelli, Elisabetta title: Clinical Features and Chest Imaging as Predictors of Intensity of Care in Patients with COVID-19 date: 2020-09-16 words: 5198 flesch: 44 summary: All these findings emphasize the importance of past medical history and comorbidities in the disease course of COVID-19 patients, as they may predispose to worse outcome and higher intensity of care. Pevious reports on CXR findings in COVID-19 patients focused on the distribution and type of lung abnormalities. keywords: admission; analysis; cardiovascular; care; chest; clinical; comorbidities; correlation; cov-2; covid-19; cxr; data; disease; features; figure; findings; fio; ggo; global; global score; higher; himc; history; hospital; hospitalization; independent; infection; intensity; level; limc; low; lung; lus; median; medical; metabolic; multivariate; need; oncologic; oxygen; pandemic; patients; pneumonia; population; radiological; respiratory; risk; role; room; sars; score; severe; smokers; smoking; studies; study; time; ultrasound cache: cord-292341-uo54ghf3.txt plain text: cord-292341-uo54ghf3.txt item: #29 of 58 id: cord-294910-gnc04ax1 author: Nogueira, Paulo Jorge title: The Role of Health Preconditions on COVID-19 Deaths in Portugal: Evidence from Surveillance Data of the First 20293 Infection Cases date: 2020-07-24 words: 4943 flesch: 36 summary: The results of the present study registered potential different pathophysiological mechanisms for COVID-19 mortality, suggesting the need for a team approach between different medical specialties in order to maximize the probabilities of recovery for COVID-19 patients. Patients: Results of the SARS-RAS Study of the Italian Society of Hypertension National age and coresidence patterns shape COVID-19 vulnerability Acute kidney injury is associated with the mortality of coronavirus disease 2019 Determinants of blood pH in health and disease Is the kidney a target of SARS-CoV-2? Kidney disease is associated with in-hospital death of patients with COVID-19 Impact of Cerebrovascular and Cardiovascular Diseases on Mortality and Severity of COVID-19-Systematic Review, Meta-analysis, and Meta-regression Issues of Cardiovascular Risk Management in People With Diabetes in the COVID-19 Era North American COVID-19 ST-segment elevation myocardial infarction (NACMI) registry: Rationale, design, and implications Takotsubo syndrome during SARS-CoV-2 pneumonia: A possible cardiovascular complication Myocardial injury determination improves risk stratification and predicts mortality in COVID-19 patients The Heart in COVID19: Primary Target or Secondary Bystander? COVID 19 and heart failure: From infection to inflammation and angiotensin II stimulation. keywords: absence; age; analysis; april; associated; cardiac; cardiovascular; care; cases; characteristics; clinical; cov-2; covid-19; data; database; death; diabetes; disease; disorder; factors; health; higher; hospitalization; increase; individuals; infected; infection; intensive; kidney; lethality; majority; male; medical; men; meta; model; mortality; multivariable; national; neuromuscular; non; observed; odds; older; outcome; patients; portugal; potential; preconditions; region; respiratory; results; risk; sars; sex; sinave; studies; study; systematic; table; variables; years cache: cord-294910-gnc04ax1.txt plain text: cord-294910-gnc04ax1.txt item: #30 of 58 id: cord-300991-ipy24zxp author: Khan, Amira Sayed title: Obesity and COVID-19: Oro-Naso-Sensory Perception date: 2020-07-08 words: 5986 flesch: 41 summary: There is no direct report available on the loss of these chemical senses in obese COVID-19 patients. Epidemiological data confirm that there is an increased rate of pneumonia and RTI in COVID-19 obese patients [12] . keywords: ace2; acute; adipose; brain; bud; cells; clinical; coronavirus; cov-2; covid-19; dcs; decreased; dendritic; detection; diabetes; diet; disease; dysfunction; entry; epithelium; expression; fat; figure; functions; genetic; gustatory; high; human; il-10; il-6; immune; immunosuppression; increase; induced; infection; inflammation; inflammatory; influenza; integrity; like; loss; low; macrophages; marked; mice; mouse; nasal; neurons; number; obese; obesity; olfactory; ons; pandemic; papillae; participants; patients; perception; recent; receptors; reduced; report; respiratory; risk; role; sars; sensory; severe; smell; study; subjects; syndrome; taste; tissue; tnf; tongue; transgenic; type; viral; virus; weight cache: cord-300991-ipy24zxp.txt plain text: cord-300991-ipy24zxp.txt item: #31 of 58 id: cord-301157-tu3iig9o author: Felsenstein, Susanna title: Presentation, Treatment Response and Short-Term Outcomes in Paediatric Multisystem Inflammatory Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) date: 2020-10-14 words: 7854 flesch: 39 summary: A subset of COVID-19 patients reportedly develop vasculitic lesions Potential cardiovascular issues in pediatric patients Myocardial localization of coronavirus in COVID-19 cardiogenic shock Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2 Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection Type 3 hypersensitivity in COVID-19 vasculitis Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 Novel paediatric presentation of COVID-19 with ARDS and cytokine storm syndrome without respiratory symptoms Thromboembolic complications of COVID-19: The combined effect of a pro-coagulant pattern and an endothelial thrombo-inflammatory syndrome Clinical outcomes in COVID-19 patients treated with tocilizumab: An individual patient data systematic review Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Use of anakinra in severe COVID-19: keywords: 10th; acute; admission; age; associated; available; background; bame; bnp; brain; cardiac; cardiovascular; cases; centile; children; clinical; cohort; common; coronary; coronavirus; corticosteroids; count; cov-2; covid-19; criteria; cytokine; data; days; diagnosis; disease; dose; echocardiogram; echocardiographic; elevated; evidence; features; febrile; figure; findings; follow; following; high; immune; infection; inflammatory; inflammatory syndrome; initial; injury; inotropes; involvement; iqr; ivig; ivmp; laboratory; levels; lymphocyte; median; mild; mis; multisystem; multisystem inflammatory; multisystem syndrome; normal; outcomes; paediatric; pandemic; parameters; patients; peak; pims; population; positive; presentation; range; respiratory; sars; severe; shock; study; symptoms; syndrome; systemic; table; treatment; troponin; weeks; years cache: cord-301157-tu3iig9o.txt plain text: cord-301157-tu3iig9o.txt item: #32 of 58 id: cord-306438-db2rqz4d author: Kalathiya, Umesh title: Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site date: 2020-05-14 words: 6937 flesch: 47 summary: Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular dynamics (MD) simulation. Interpretations from MD simulations suggest that the monomer form of spike protein is in constant motion showing transitions between an “up” and “down” state. keywords: ace2; active; addition; affinity; amino; analysis; binding; bouncing; cavity; cell; chains; chitosan; compounds; conformation; coronavirus; cov-2; covid-19; data; different; discovery; disease; docking; domain; drug; dynamics; figure; findings; form; fusion; glycoprotein; high; homotrimer; host; hr1; human; infection; inhibitor; interactions; ligand; mechanism; model; molecular; molecules; monomer; monomeric; movement; novel; open; paclitaxel; pocket; potential; protease; protein; range; rapamycin; rbd; rbd domain; receptor; regions; repurposing; residues; respiratory; ritonavir; rna; sars; screening; sequence; severe; simulations; small; spike; spike glycoprotein; spike protein; spring; stable; state; structure; studies; subunit; syndrome; systems; target; trimer; variability; viral; virtual cache: cord-306438-db2rqz4d.txt plain text: cord-306438-db2rqz4d.txt item: #33 of 58 id: cord-309273-gtvi37gh author: Flesia, Luca title: Predicting Perceived Stress Related to the Covid-19 Outbreak through Stable Psychological Traits and Machine Learning Models date: 2020-10-19 words: 7913 flesch: 40 summary: A more complete descriptive analysis of each variable, including the composition of high perceived stress versus low perceived stress samples, is reported in the Supplementary Materials. The effects of psychological stress on depression Chronic stress, hair cortisol and depression: A prospective and longitudinal study of medical internship Heightened biological stress response during exposure to a trauma film predicts an increase in intrusive memories A direct test of the diathesis-stress model for depression Psychological stress and coping in adaptation and illness Recommended psychological crisis intervention response to the 2019 novel coronavirus pneumonia outbreak in China: A model of West China Hospital. keywords: age; analysis; associated; average; behavior; bfi-10; chinese; class; control; coronavirus; covid-19; data; differences; dispositional; distress; education; efficacy; emergency; emotional; epidemic; events; external; factors; gender; health; high; higher; impact; important; income; individual; internal; italian; item; learning; levels; life; living; locus; lower; machine; materials; measures; mental; model; normative; online; outbreak; outcomes; pandemic; participants; people; personality; persons; physical; population; positive; predictors; present; protective; pss-10; psychological; questionnaire; regression; reported; research; responses; results; risk; role; sample; sars; scale; score; self; set; significant; social; sociodemographic; stability; stable; strategies; stress; stressful; studies; study; supplementary; symptoms; test; traits; variables cache: cord-309273-gtvi37gh.txt plain text: cord-309273-gtvi37gh.txt item: #34 of 58 id: cord-309876-l0xginsa author: Vena, Antonio title: Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors date: 2020-08-27 words: 3076 flesch: 39 summary: A nationwide, population-based seroepidemiological study SARS-CoV-2 antibodies in adults in Madrid Seroprevalence of SARS-CoV-2-Specific Antibodies Estimated Community Seroprevalence of SARS-CoV-2 Antibodies-Two Georgia Counties Population Point Prevalence of SARS-CoV-2 Infection Based on a Statewide Random Sample-Indiana SARS-CoV-2 IgG seroprevalence in blood donors located in three different federal states Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone Seroprevalence of SARS-CoV-2-Specific Antibodies Among Adults Preventing the Spread of COVID-19 to Nursing Homes: Experience from a Singapore Geriatric Centre Nursing Homes with COVID-19 Cases Epidemiology of Covid-19 in a Long-Term Care Facility Understanding infection prevention and control in nursing homes: A qualitative study Infection Prevention and Control Programs in US Nursing Homes: Results of a National Survey Severe Respiratory Illness Associated with Human Metapneumovirus in Nursing Home Viral respiratory infections in a nursing home: A six-month prospective study Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective Infections in Nursing Homes: Epidemiology and Prevention Programs High prevalence of olfactory and taste disorder during SARS-CoV-2 infection in outpatients CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection Asymptomatic coronavirus infection: MERS-CoV and SARS-CoV-2 (COVID-19) Participants were tested for anti-SARS-CoV-2 antibodies [Immunoglobulin G (IgG) and M (IgM) class antibodies] at three private laboratories (Istituto Diganostico Varelli, Medical Center, and Casa della Salute di Genova). keywords: administrative; adults; age; antibodies; antibody; associated; blood; care; cases; clinical; covid-19; data; departments; exposure; facilities; factors; higher; highest; igg; igm; individuals; infected; infection; italian; italy; laboratory; liguria; long; nursing; occupational; participants; patients; population; positive; positivity; prevalence; sars; seroprevalence; study; symptoms; table; taste; term; tests; virus; years cache: cord-309876-l0xginsa.txt plain text: cord-309876-l0xginsa.txt item: #35 of 58 id: cord-310304-f28tjmi8 author: Alcendor, Donald J. title: Racial Disparities-Associated COVID-19 Mortality among Minority Populations in the US date: 2020-07-30 words: 7730 flesch: 35 summary: Aggressive strategies to help minority patients at higher risk understand the seriousness of COVID-19 disease could include direct mailings, providing patients with samples of masks and sanitizers, COVID-19 office placards, COVID-19 infomercials in waiting areas, wellness checks, and COVID-19 information for family members and caretakers. COVID-19 patients with diabetes are at increased risk of having adverse clinical complications, including death [37, 38] . keywords: aas; access; ace2; aceis; acute; alveolar; angiotensin; blood; cardiovascular; care; cells; changes; china; chronic; clinical; communities; complications; control; copd; coronavirus; cov-2; covid-19; covid-19 patients; covs; cvd; cytokine; death; determinants; development; diabetes; disease; disparities; distress; dysfunction; entry; essential; ethnic; expression; factors; failure; figure; health; heart; higher; hypertension; increase; individuals; infected; infection; inflammation; injury; leakage; levels; likely; lung; management; medical; minority; model; mortality; novel; patients; pneumocytes; policy; poor; populations; pressure; pulmonary; racial; rate; receptor; related; renin; respiratory; review; risk; sars; severe; social; socioeconomic; storm; study; syndrome; system; type; vascular; viral; wuhan cache: cord-310304-f28tjmi8.txt plain text: cord-310304-f28tjmi8.txt item: #36 of 58 id: cord-315188-a9pvugjt author: Choi, Min Hyuk title: Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea date: 2020-06-23 words: 4149 flesch: 39 summary: In previous studies of COVID-19 patients [8, 12] , mild cases were defined as patients who experienced mild symptoms, with no manifestations of pneumonia on chest imaging. The use of the triage algorithm and KCDC classification for COVID-19 patients saves medical resources, allowing more efficient treatment and management of patients. keywords: ace2; admission; angiotensin; asymptomatic; cases; characteristics; chest; classification; clinical; coronavirus; covid-19; covid-19 patients; days; diabetes; disease; drugs; early; factors; greater; group; history; hospital; hypertension; ibuprofen; improvement; infection; initial; kcdc; korea; lopinavir; matching; medical; mild; novel; onset; outcomes; patients; pneumonia; progression; proportion; receptor; respiratory; risk; ritonavir; score; severe; severity; south; stabilization; studies; study; symptoms; table; treatment; triage; use; variables; wuhan cache: cord-315188-a9pvugjt.txt plain text: cord-315188-a9pvugjt.txt item: #37 of 58 id: cord-315634-fkm6slkc author: Jouffroy, Romain title: Hypoxemia Index Associated with Prehospital Intubation in COVID-19 Patients date: 2020-09-20 words: 4061 flesch: 39 summary: key: cord-315634-fkm6slkc authors: Jouffroy, Romain; Kedzierewicz, Romain; Derkenne, Clement; Bertho, Kilian; Scannavino, Marine; Frattini, Benoit; Lemoine, Frederic; Jost, Daniel; Prunet, Bertrand title: Hypoxemia Index Associated with Prehospital Intubation in COVID-19 Patients date: 2020-09-20 journal: J Clin Med DOI: 10.3390/jcm9093025 sha: doc_id: 315634 cord_uid: fkm6slkc Background: There exists a need for prognostic tools for the early identification of COVID-19 patients requiring prehospital intubation. Conclusion: An HI of <1.3 was associated with a 3-fold increase in prehospital intubation among COVID-19 patients. keywords: active; acute; als; analysis; arf; blood; brigade; care; chronic; clinical; cov-2; covid-19; curve; disease; emergency; failure; figure; fire; flow; hypoxemia; index; initial; intubated; intubation; life; mean; optimal; ora; oxygen; paris; patients; prehospital; prehospital intubation; rate; ratio; respiratory; results; risk; roc; sars; setting; severe; spo; study; support; team; threshold; treatment; ventilation; years cache: cord-315634-fkm6slkc.txt plain text: cord-315634-fkm6slkc.txt item: #38 of 58 id: cord-315696-43wmazxa author: Marinaki, Smaragdi title: A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts date: 2020-09-16 words: 6026 flesch: 40 summary: Initial report from the US epicenter Infection in solid-organ transplant recipients COVID-19 in kidney transplant recipients A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement Coronavirus Disease (COVID-19) in Kidney and Liver Transplant Patients: A Single-Center Experience Interleukin-6 receptor antagonist therapy to treat SARS-CoV-2 driven inflammatory syndrome in a kidney transplant recipient Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) A catabolic state in a kidney transplant recipient with COVID-19 Immunosuppressive therapy maintenance in a kidney transplant recipient with SARS-CoV-2 pneumonia: A case report A familial cluster, including a kidney transplant recipient Coronavirus disease 2019 in renal transplant recipients: Report of two cases COVID-19) in a Renal Transplant Patient Fatal SARS-CoV-2 infection in a renal transplant recipient COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine COVID-19 in kidney transplant recipients Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? Should cyclosporine be useful in renal transplant recipients affected by SARS-CoV-2? SARS-CoV-2 infection in kidney transplant recipients: keywords: acute; admission; adverse; agents; aki; analysis; anti; ards; articles; available; baseline; boluses; case; center; cfr; characteristics; clinical; cohort; comorbidities; coronavirus; cov-2; covid-19; covid-19 infection; data; death; disease; donor; early; high; hospitalization; hydroxychloroquine; icu; infection; kidney; kidney transplant; ktx; management; mean; mechanical; median; organ; outcomes; patients; pneumonia; population; quality; range; rate; recipients; renal; reported; reports; review; risk; sars; series; severe; solid; studies; study; supplementary; systematic; therapeutic; time; tocilizumab; total; transplant; transplant recipients; transplantation; ventilation; years cache: cord-315696-43wmazxa.txt plain text: cord-315696-43wmazxa.txt item: #39 of 58 id: cord-318018-ybdkp398 author: Bruni, Margherita title: Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers date: 2020-10-01 words: 5489 flesch: 37 summary: The presence of few false positives among the COVID-negative population tested with the viral nucleocapsid protein as compared to the RBD might be a consequence of a mistakenly detection of anti-N antibodies previously raised against common cold coronaviruses which cross-react with the SARS-CoV-2 nucleocapsid [23] . On the contrary, even in the early convalescent phase, those cytokines were undetectable in the sera of non-hospitalized COVID-19 patients (Figure 2A) . keywords: antibodies; antibody; antigens; assay; associated; care; cells; classes; clearance; clinical; consequence; coronavirus; cov-2; covid-19; covid-19 patients; cytokines; detection; different; disease; elisa; figure; hcl; health; hospitalized; humoral; icu; iga; igg; igm; il-6; immune; infected; infection; inflammatory; june; levels; lower; mediators; nacl; negative; non; nucleocapsid; patients; persistence; population; positive; presence; protein; rbd; respiratory; response; sars; sera; serological; serum; severe; severity; specific; specificity; spike; study; subjects; supplementary; symptoms; table; test; time; titers; variables; viral; virus; workers cache: cord-318018-ybdkp398.txt plain text: cord-318018-ybdkp398.txt item: #40 of 58 id: cord-318211-hhp84ygq author: Ticconi, Carlo title: Pregnancy-Related Complications in Women with Recurrent Pregnancy Loss: A Prospective Cohort Study date: 2020-09-01 words: 4912 flesch: 43 summary: General characteristics of study women. The detailed rates of concomitant pregnancy complications in study women are reported in Table 5 . keywords: analysis; birth; causes; cohort; complications; conditions; control; control women; diagnostic; disorders; effect; fetal; follow; following; gestational; group; higher; live; losses; major; miscarriage; multiple; normal; number; outcome; overall; preeclampsia; pregnancies; pregnancy; pregnancy complications; pregnant; present; previous; primary; rates; recurrent; risk; rpl; secondary; specific; spontaneous; studies; study; successive; table; term; test; unexplained; weeks; women cache: cord-318211-hhp84ygq.txt plain text: cord-318211-hhp84ygq.txt item: #41 of 58 id: cord-320823-a1fq6mno author: Moula, Amalia Ioanna title: Quantification of Death Risk in Relation to Sex, Pre-Existing Cardiovascular Diseases and Risk Factors in COVID-19 Patients: Let’s Take Stock and See Where We Are date: 2020-08-19 words: 4140 flesch: 47 summary: Both ACE2 receptors and CD26 are targets for coronaviruses, and their overexpression in older patients might mediate the increased fatality rate in COVID-19 patients [40] . Patients with pre-existing cerebrovascular disease tend to die 1.76-fold more than patients without cerebrovascular disease, suggesting that cerebrovascular disease is a strong predictor of death ( Figure 4E , RR: 1.76 keywords: ace2; age; analysis; articles; association; bias; cad; cardiovascular; cases; cerebrovascular; characteristics; china; clinical; coronavirus; cov-2; covid-19; cvd; data; death; diabetes; disease; existing; factors; fatality; figure; fold; funnel; higher; hypertension; increase; infection; low; mellitus; meta; mortality; outcomes; papers; patients; plot; pre; presence; retrospective; risk; sars; search; sex; studies; study; system; wuhan cache: cord-320823-a1fq6mno.txt plain text: cord-320823-a1fq6mno.txt item: #42 of 58 id: cord-320882-cr0ccsnp author: Li Volti, Giovanni title: Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships? date: 2020-05-02 words: 1237 flesch: 40 summary: The authors present findings linking ACE-2 expression to smoking in a variety of experimental models together with observations of their own; immunohistochemistry data showing an increased expression of ACE-2 in a series of biopsies from a group of current smokers with chronic obstructive pulmonary disease when compared to a control group. The authors then venture into reporting existing Chinese case reports to support their hypothesis that smoking could increase the risk of COVID-19 via upregulation of ACE-2 expression, a known cellular entry gateway for SARS-CoV-2 [2] . keywords: ace2; acute; angiotensin; authors; cigarettes; complex; converting; coronavirus; cov-2; covid-19; disease; electronic; enzyme; expression; health; infection; lung; patients; potential; prevalence; protein; receptor; research; risk; sars; smoking; therapeutics; tobacco cache: cord-320882-cr0ccsnp.txt plain text: cord-320882-cr0ccsnp.txt item: #43 of 58 id: cord-322184-kgv9f58a author: Sohn, Yujin title: Assessing Viral Shedding and Infectivity of Asymptomatic or Mildly Symptomatic Patients with COVID-19 in a Later Phase date: 2020-09-10 words: 3482 flesch: 51 summary: Viral culture studies using patient specimens to confirm the presence of infectious SARS-CoV-2 are still limited. SARS-CoV-2 infection is confirmed by the detection of viral RNA using reverse transcription polymerase chain reaction (RT-PCR). keywords: assay; asymptomatic; cases; cells; coronavirus; cov-2; covid-19; culture; days; detection; diagnosis; disease; infection; isolation; nasopharyngeal; onset; patients; pcr; phase; presence; respiratory; results; risk; rna; saliva; salivary; sars; shedding; specimens; study; swab; symptoms; tool; transmission; values; viral; virus cache: cord-322184-kgv9f58a.txt plain text: cord-322184-kgv9f58a.txt item: #44 of 58 id: cord-325014-n7mnhk2v author: Gujski, Mariusz title: Prevalence of Current and Past SARS-CoV-2 Infections among Police Employees in Poland, June–July 2020 date: 2020-10-11 words: 4900 flesch: 43 summary: Participants aged ≥60 years had a higher odds of positive IgG index vs. those aged 20–29 years (OR: 3.309). Daily vaping also increased the odds of positive IgG index (OR: 2.058). keywords: age; anti; antibodies; antibody; asymptomatic; available; cases; cigarette; civilian; clinical; coronavirus; cov-2; covid-19; cross; current; data; disease; elisa; employees; equivocal; higher; igg; igg index; igm+iga; igm+iga index; index; individuals; infection; laboratory; negative; number; odds; officers; overall; participants; past; pcr; poland; police; population; positive; positive anti; prevalence; questionnaire; results; risk; samples; sars; serological; significant; study; subjects; symptoms; test; testing; units; use; variables; women; work; years cache: cord-325014-n7mnhk2v.txt plain text: cord-325014-n7mnhk2v.txt item: #45 of 58 id: cord-325093-g2llk2p0 author: Pomara, Cristoforo title: COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy! date: 2020-04-26 words: 1235 flesch: 38 summary: Autopsy findings and clinical diagnoses: A review of 1,000 cases Comparison of premortem clinical diagnoses in critically ill patients and subsequent autopsy findings Learning from the dead Outbreak of influenza a viral infection in Ghana: A consideration of autopsy findings and a mini-review of the literature Ebola virus shedding and transmission: Review of current evidence Validity of a minimally invasive autopsy for cause of death determination in adults in mozambique: An observational study A case of severe Ebola virus infection complicated by gram-negative septicemia Severe Ebola virus infection complicated by gram-negative septicemia Ebola virus disease complicated with viral interstitial pneumonia: Please, Autopsy, Autopsy, Autopsy! date: 2020-04-26 journal: J Clin Med DOI: 10.3390/jcm9051259 sha: doc_id: 325093 cord_uid: g2llk2p0 The current outbreak of COVID-19 severe respiratory disease, which started in Wuhan, China, is an ongoing challenge, and a major threat to public health that requires surveillance, prompt diagnosis, and research efforts to understand this emergent pathogen and to develop an effective response. keywords: autopsies; autopsy; clinical; control; covid-19; death; diagnosis; disease; ebola; effective; efforts; findings; infection; limited; number; outbreak; patients; postmortem; transmission; treatment; useful; virus cache: cord-325093-g2llk2p0.txt plain text: cord-325093-g2llk2p0.txt item: #46 of 58 id: cord-325307-agaau27o author: Giavedoni, Priscila title: Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity date: 2020-10-12 words: 4311 flesch: 34 summary: Second, we provide an accurate description of the prevalence of skin lesions in COVID-19 patients. Moreover, differentiating chilblain-like lesions from idiopathic and lupus-associated chilblain lesions, and other types of lesions such as generalized maculopapular or urticarial eruptions from drug reactions, is essential, given the frequency and characteristics of the former and the difficulties posed by the latter due to the large number of drugs usually concomitantly received by COVID-19 patients. keywords: addition; associated; cases; characteristics; chilblain; clinical; cov-2; covid-19; cutaneous; days; deposition; dermal; dif; direct; disease; eruptions; features; figure; findings; grover; histologic; histopathology; hospital; igm; ihc; immunofluorescence; immunohistochemistry; infection; lesions; like; like lesions; livedo; magnification; manifestations; median; original; patients; patterns; pcr; radiological; related; respiratory; reticularis; sars; series; skin; skin lesions; specific; studies; study; symptoms; table; test; time; type; vesicular; vessels cache: cord-325307-agaau27o.txt plain text: cord-325307-agaau27o.txt item: #47 of 58 id: cord-325559-di8lljoi author: Cappello, Francesco title: Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis date: 2020-06-29 words: 5212 flesch: 36 summary: By resorting to previously known information on genome sequences and protein structures and functions as well, bioinformaticians have been successfully assisting virologists by structurally characterizing proteins of the novel virus, determining the evolutionary trajectories, identifying interactions with host proteins, and providing other important biological insights. Alphavirus Sequence alignment of structural polyproteins belonging to arthritogenic alphaviruses revealed conserved regions which share homology with human proteins implicated in rheumatoid arthritis. keywords: activation; acute; ade; aminotransferase; analysis; antibodies; antigens; autoantibodies; autoimmunity; available; blood; body; cases; cells; chaperones; chemokine; clinical; clues; coronavirus; cov-2; covid-19; cross; damage; data; dic; disease; drugs; epitopes; example; factors; generalized; higher; host; hsp; hsp60; human; hypothesis; il6; immune; infection; inflammatory; information; innate; laboratory; levels; lower; mechanism; medical; membrane; mimicry; molecular; motif; novel; pathogenesis; pathogenic; patients; phenomena; plasma; platelet; pneumonia; proteins; research; researchers; respiratory; response; sars; scientific; severe; spike; step; stress; structural; syndrome; system; systemic; table; time; upper; viral; virus cache: cord-325559-di8lljoi.txt plain text: cord-325559-di8lljoi.txt item: #48 of 58 id: cord-326834-eeldyj2u author: Graziani, Desirée title: Characteristics and Prognosis of COVID-19 in Patients with COPD date: 2020-10-12 words: 4371 flesch: 40 summary: The demographic and clinical characteristics of COVID-19 patients with and without COPD are shown in Table 1 . The demographic and clinical characteristics of COVID-19 patients with and without COPD are shown in Table 1 . keywords: age; analysis; associated; cardiovascular; cases; characteristics; chronic; clinical; comorbidities; copd; copd patients; cov-2; covid-19; data; diagnosis; disease; exacerbations; factors; failure; free; general; heart; higher; hospital; impact; information; mortality; obstructive; older; pandemic; patients; pcr; pneumonia; population; precision; prevalence; prognosis; pulmonary; rates; records; results; risk; sars; savana; severe; studies; study; system; table; tests; variables; winter; years cache: cord-326834-eeldyj2u.txt plain text: cord-326834-eeldyj2u.txt item: #49 of 58 id: cord-327610-cm3vkpcn author: Fukuda, Yosuke title: Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach date: 2020-08-13 words: 8213 flesch: 33 summary: A previous study confirmed elevated expression of interferon (IFN) and Type 2 cytokines analyzed from bronchosorption and nasosorption in asthma patients infected with HRV [8] . Despite recent advances in understanding the cellular and molecular mechanisms underlying asthma exacerbations, current therapeutic modalities are inadequate for complete prevention and treatment of these episodes. keywords: activation; activity; acute; adults; airway; airway inflammation; allergic; anti; apoptosis; asthma; asthma exacerbations; asthmatic; basic; bronchial; cells; cellular; chronic; clinical; control; copd; cxcl8; cytokines; deacetylation; disease; effective; effects; eosinophilic; epithelial; essential; exacerbations; experiments; expression; factor; function; group; growth; hrv; human; ifn; ige; il-17; il-5; il-6; ilc2; immune; important; increase; induced; infection; inflammation; inflammatory; inhibited; inhibition; inhibits; known; leptin; levels; lipid; lung; mechanisms; mediators; metformin; mice; model; mouse; nasal; neutrophilic; non; novel; nrf2; obstructive; omalizumab; ovalbumin; pathway; patients; placebo; production; protein; pulmonary; receptor; reduced; refractory; regulates; relationship; release; remodeling; respiratory; response; results; resveratrol; rhinovirus; role; rsv; senescence; serum; severe; signaling; sirt1; steroid; studies; study; symptoms; syncytial; target; tgf; th17; th2; theophylline; therapeutic; treatment; trial; type; viral; virus cache: cord-327610-cm3vkpcn.txt plain text: cord-327610-cm3vkpcn.txt item: #50 of 58 id: cord-331347-imexhlwn author: Anzai, Asami title: Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) date: 2020-02-24 words: 4482 flesch: 51 summary: The cumulative number of exported COVID-19 cases observed in the former scenario is denoted m, To estimate the reduced volume of exported cases, we employ a counterfactual model. Supposing that h(t) is the observed number of cases on day t, the reduced travel volume of exported cases by Day 67 is calculated as: . keywords: cases; china; contacts; coronavirus; covid-19; data; day; days; delay; epidemic; epidemiological; exponential; figure; growth; impact; infected; january; japan; lockdown; major; major epidemic; movement; novel; number; observed; probability; reduced; reduction; restrictions; study; time; transmission; travel; travel volume; volume; wuhan cache: cord-331347-imexhlwn.txt plain text: cord-331347-imexhlwn.txt item: #51 of 58 id: cord-332180-dw4h69tp author: Cheng, Fu-Yuan title: Using Machine Learning to Predict ICU Transfer in Hospitalized COVID-19 Patients date: 2020-06-01 words: 4130 flesch: 39 summary: The non-ICU bed to ICU transfer rate in our cohort was 3.7 percent, which created an extreme class imbalance between the majority class (feature vectors without the occurrence of ICU transfer within 24 h) and the minority class (feature vectors with ICU transfer within 24 h). Low sample size and class imbalance resulting from low ICU transfer rates are major limitations to this version of the model, which resulted in low precision. keywords: acute; assessments; blood; care; class; clinical; cohort; coronavirus; count; covid-19; critical; data; deterioration; disease; feature; frequent; health; high; higher; hospital; icu; icu transfer; laboratory; learning; lower; machine; management; model; mortality; need; non; oxygen; patients; performance; predictive; rate; resources; respiratory; review; risk; saturation; sensitivity; set; severe; signs; stay; study; system; table; test; time; tool; training; transfer; value; variables; vectors; vital cache: cord-332180-dw4h69tp.txt plain text: cord-332180-dw4h69tp.txt item: #52 of 58 id: cord-333520-v2sb90rc author: Gardin, Chiara title: Could Mesenchymal Stem Cell-Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients? date: 2020-08-26 words: 10167 flesch: 29 summary: Several studies agree that reduced fibrosis and apoptosis of myocardial cells are other important effects of the EV-mediated ischemic cardiac repair Evidence from meta-analysis Cardiovascular disease and COVID-19 Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Inside the heart of COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Clinical Characteristics of Coronavirus Disease 2019 in China COVID-19 and the cardiovascular system Mesenchymal stem cells and management of COVID-19 pneumonia Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury On the use of corticosteroids for 2019-nCoV pneumonia Coronaviruses and the cardiovascular system: Acute and long-term implications Treatment for emerging viruses: Convalescent plasma and COVID-19 Recommendations for Investigational COVID-19 Convalescent Plasma Chinese Clinical Trial Registry Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. keywords: ace2; acute; acute lung; addition; adipose; administration; ali; alveolar; ami; angiogenesis; angiotensin; animal; anti; apoptosis; ards; authors; blood; bone; cardiac; cardiomyocyte; cardiovascular; cells; china; clinical; colleagues; converting; coronavirus; cov-2; covid-19; cytokine; date; diabetes; different; disease; distress; edema; effects; endothelial; endotoxin; enzyme; epithelial; evidence; evs; exosomes; expression; extracellular; factor; failure; fibrosis; fluid; function; growth; heart; human; ill; immunomodulatory; improved; increase; infection; inflammation; inflammatory; inhibitors; injury; ischemic; isolated; levels; lung; lung injury; macrophages; management; marrow; mechanisms; membrane; mesenchymal; mesenchymal stem; metabolic; mice; mitochondria; model; mrna; msc; mscs; mvs; myocardial; novel; patients; permeability; pneumonia; potential; proliferation; properties; protein; pulmonary; receptor; reduced; reduction; regulation; reperfusion; respiratory; response; sars; secretion; secretome; severe; size; stem; stem cells; stromal; studies; study; survival; syndrome; system; t cells; target; therapeutic; therapy; tissue; tnf; transfer; treatment; use; ventilation; vesicles; viral cache: cord-333520-v2sb90rc.txt plain text: cord-333520-v2sb90rc.txt item: #53 of 58 id: cord-333959-8ermzrmr author: Gao, Zan title: Virtual Reality Exercise as a Coping Strategy for Health and Wellness Promotion in Older Adults during the COVID-19 Pandemic date: 2020-06-25 words: 5573 flesch: 39 summary: In addition, there is a need for more research investigating the effectiveness of VR exercise programs on older adults' weight loss, as VR exercise has only recently been applied as a means for weight control. These findings support the effectiveness of VR exercise interventions in reducing fall rates and improving balance in older adults. keywords: ability; activity; adults; anxiety; balance; better; cbt; cognition; cognitive; control; covid-19; depression; disorders; effective; effects; elderly; exercise; falls; fear; findings; fit; functioning; group; health; home; immersive; improved; increase; intervention; life; loss; memory; mental; motor; non; obesity; older; older adults; outcomes; participants; patients; physical; population; program; promise; promotion; psychological; reality; rehabilitation; research; risk; significant; strategy; strength; studies; study; technology; traditional; training; treadmill; virtual; vr exercise; weight; wii cache: cord-333959-8ermzrmr.txt plain text: cord-333959-8ermzrmr.txt item: #54 of 58 id: cord-336257-f6yglaz8 author: Forte, Giuseppe title: The Enemy Which Sealed the World: Effects of COVID-19 Diffusion on the Psychological State of the Italian Population date: 2020-06-10 words: 4358 flesch: 43 summary: Among all respondents, only 9 (0.4%) were infected by the COVID-19, and 40 (1.7%) were sure that they had had close contacts with individuals suspected of COVID-19 infection (see Table 1 ). Of the overall sample, 112 respondents (4.9%) and 177 (7.7%) respectively knew people dead and patients in intensive care units (ICU) because of COVID-19 infection. keywords: anxiety; areas; consequences; considered; covid-19; data; differences; distress; emergency; epidemic; factors; general; health; higher; ies; impact; infection; italian; italy; items; measures; mental; mood; outbreak; pandemic; participants; people; point; population; psychological; psychopathological; ptsd; questionnaire; related; respondents; results; risk; sample; scale; scl-90; significant; sleep; social; stai; state; studies; study; survey; symptomatology; symptoms; table; trait cache: cord-336257-f6yglaz8.txt plain text: cord-336257-f6yglaz8.txt item: #55 of 58 id: cord-336810-77wq9laa author: Klocperk, Adam title: Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19 date: 2020-09-17 words: 4688 flesch: 36 summary: Individually, laboratory abnormalities have been reported in COVID-19 patients, including an elevation of inflammatory markers and liver enzymes, abnormal renal function tests, and an elevated serum soluble interleukin 2 (IL-2) receptor (sIL2R) and IL-6. As a contribution to the current knowledge pool, our report describes a representative cohort of COVID-19 patients hospitalized during the pandemic in a large Czech hospital. keywords: activation; acute; analysis; anti; associated; biliary; cd8; cells; characteristics; clinical; cohort; coronavirus; correlation; course; cov-2; covid-19; covid-19 patients; crp; damage; disease; elevated; elevation; enzymes; failure; fatal; fatal course; figure; ggt; healthy; high; hospital; igg; il-6; immune; immunity; infection; infiltration; inflammation; inflammatory; injury; laboratory; levels; liver; lungs; lymphopenia; markers; mild; moderate; multi; observed; organ; parameters; patients; procalcitonin; receptor; respiratory; response; risk; sars; serum; severe; severe course; severe covid-19; severity; sil2r; specific; study; symptoms; syndrome; t cells; usa cache: cord-336810-77wq9laa.txt plain text: cord-336810-77wq9laa.txt item: #56 of 58 id: cord-345728-41k1bljo author: Al’joboori, Yazi title: The Effects of Adding Transcutaneous Spinal Cord Stimulation (tSCS) to Sit-To-Stand Training in People with Spinal Cord Injury: A Pilot Study date: 2020-08-26 words: 8519 flesch: 42 summary: Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation Hindlimb stepping movements in complete spinal rats induced by epidural spinal cord stimulation Epidural stimulation induced modulation of spinal locomotor networks in adult spinal rats Evidence for a spinal central pattern generator in humans Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: Electromyographic study of compound muscle action potentials Initiating extension of the lower limbs in subjects with complete spinal cord injury by epidural lumbar cord stimulation Common neural structures activated by epidural and transcutaneous lumbar spinal cord stimulation: Elicitation of posterior root-muscle reflexes Stimulation of the human lumbar spinal cord with implanted and surface electrodes: A computer simulation study Neurophysiological characterization of transpinal evoked potentials in human leg muscles Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord Posterior root-muscle reflexes elicited by transcutaneous stimulation of the human lumbosacral cord Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity Self-Assisted Standing Enabled by Non-Invasive Spinal Stimulation after Spinal Cord Injury Body Position Influences Which Neural Structures Are Recruited by Lumbar Transcutaneous Spinal Cord Stimulation Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: A case study Epidural Spinal Cord Stimulation Facilitates Immediate Restoration of Dormant Motor and Autonomic Supraspinal Pathways after Chronic Neurologically Complete Spinal Cord Injury Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia Modulation effects of epidural spinal cord stimulation on muscle activities during walking Suprasegmentally induced motor unit activity in paralyzed muscles of patients with established spinal cord injury Effects of transcutaneous spinal cord stimulation on voluntary locomotor activity in an incomplete spinal cord injured individual Augmentation of Voluntary Locomotor Activity by Transcutaneous Spinal Cord Stimulation in Motor-Incomplete Spinal Cord-Injured Individuals Modification of spasticity by transcutaneous spinal cord stimulation in individuals with incomplete spinal cord injury Transcutaneous Spinal Cord Stimulation Induces Temporary Attenuation of Spasticity in Individuals with Spinal Cord Injury Priming Neural Circuits to Modulate Spinal Reflex Excitability. Improvements in health-related quality of life were detected in SF-36 subcategories including physical, emotional, vitality, social functioning and pain in STIM group participants. keywords: ability; activation; activity; ais; ankle; baseline; bmca; body; bws; category; changes; chronic; complete; control; cord; cord injury; data; effects; emg; epidural; extension; figure; flexion; functional; group; health; hip; improvements; individuals; injuries; injury; intervention; isncsci; knee; left; leg; life; limb; loading; lower; manoeuvre; measures; motor; movements; muscle; non; pain; participants; people; physical; post; presence; quality; recovery; role; rom; sci; scores; session; sf-36; spasticity; spinal; spinal cord; stand; standing; stim; stim group; stimulation; study; sub; threshold; training; transcutaneous; trial; tscs; upper; volitional; voluntary; weeks cache: cord-345728-41k1bljo.txt plain text: cord-345728-41k1bljo.txt item: #57 of 58 id: cord-352668-qjlqsb2k author: Cabello, Francisco title: Consensus on Recommendations for Safe Sexual Activity during the COVID-19 Coronavirus Pandemic date: 2020-07-20 words: 4842 flesch: 37 summary: Possible pharmaceutical and behavioral approaches Sexual function and depressive symptoms among male North American medical students Intimacy and belonging: The association between sexual activity and depression among older adults Factors associated with sexual health and well being in older adulthood Feeling Good is Good for you: How Pleasure Can Boost Your Immune System and Lengthen Your Life Sex for the mature adult: Health, self-esteem and countering ageist stereotypes Secrets of the Super Young Is good sex good for you? In all other cases (for those under quarantine, those with some clinical symptoms, health professionals in contact with COVID-19 patients, and during pregnancy), abstaining from coital/oral/anal sex, substituting it with masturbatory or virtual sexual activity to provide maximum protection from the contagion, and increasing the benefits inherent to sexual activity are recommended. keywords: activity; advisable; anxiety; associated; asymptomatic; benefits; cases; clinical; confinement; consensus; contact; contagion; coronavirus; cov-2; covid-19; current; days; disease; effects; erotic; evidence; factors; good; health; high; household; immune; incubation; infected; infection; information; intercourse; life; living; mental; negative; new; oral; pandemic; partner; patients; people; period; physical; population; positive; possible; potential; precautions; pregnant; prevention; previous; quarantine; recent; recommendations; reproductive; risk; safe; sars; scenarios; sexual; sexual activity; sexual partner; sexuality; stress; study; symptoms; system; time; transmission; viral; women; workers cache: cord-352668-qjlqsb2k.txt plain text: cord-352668-qjlqsb2k.txt item: #58 of 58 id: cord-354717-4vrqzbof author: Linton, Natalie M. title: Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case Data date: 2020-02-17 words: 3130 flesch: 42 summary: SIAM Rev Stan Modeling Language Users Guide and Reference Manual, Version 2.22.0 Incubation periods of acute respiratory viral infections: A systematic review Association between severity of MERS-CoV infection and incubation period This study was made possible only through open sharing of case data from China and other countries where cases were diagnosed. keywords: admission; available; cases; covid-19; data; dates; days; death; deceased; disease; distribution; epidemic; estimates; exposure; fit; hospital; human; illness; illness onset; incubation; incubation period; infections; interval; mean; onset; period; present; residents; respiratory; right; study; time; transmission; truncation; wuhan cache: cord-354717-4vrqzbof.txt plain text: cord-354717-4vrqzbof.txt