








key: cord-327036-0260rrdx
authors: Dominguez‐Santas, M.; Diaz‐Guimaraens, B.; Garcia Abellas, P.; Moreno‐Garcia del Real, C.; Burgos‐Blascoª, P.; Suarez‐Valle, A.
title: Cutaneous small‐vessel vasculitis associated with novel 2019 coronavirus SARS‐CoV‐2 infection (COVID‐19)
date: 2020-05-26
journal: J Eur Acad Dermatol Venereol
DOI: 10.1111/jdv.16663
sha: 
doc_id: 327036
cord_uid: 0260rrdx

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has rapidly become a global health issue. Although it is known to produce diverse cutaneous manifestations, some of them have yet to be described. This letter reports new dermatologic findings associated with a confirmed COVID‐19 case.

This article is protected by copyright. All rights reserved

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global health issue. Although it is known to produce diverse cutaneous manifestations, some of them have yet to be described. This letter reports new dermatologic findings associated with a confirmed COVID-19 case.

A 71-year-old female presented to our emergency department in April 2020, in the midst of the COVID-19 pandemic. She reported the onset of fever, cough and malaise 9 days before admission, and she noticed the appearance of pruritic skin lesions in both legs on the seventh day from the start of symptoms. Her husband had also been hospitalized 2 weeks before due to COVID-19-induced pneumonia. Although the rRT-PCR from skin biopsy was negative, we believe that CSVV arising in the context of a COVID-19 infected person is no coincidence and should not be categorized as idiopathic. There are numerous reports of viral-induced vasculitis, either associated with cryoglobulin presence (as in HCV infected patients) 4 , or unrelated to them (as in individuals with influenza-vaccine-induced vasculitis) 5 . We believe that this negative rRT-PCR result has two possible explanations, the first and most likely, that immunocomplexes involved in this CSVV do not carry viable viruses, and the second being a lack of sensitivity of the test.

By sharing this case we hope to improve the scarce knowledge we have on this disease. Doctors dealing with CSVV in undiagnosed patients during this pandemic may take into consideration testing for SARS-CoV-2.

Petechial Skin Rash Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients

Morbilliform Exanthem Associated with COVID-19. JAAD Case Rep 2020

Vasculitis Following Influenza Vaccination: A Review of the Literature

Acknowledgements: The patients in this manuscript have given written informed consent to the publication of their case details.Bibliography:

