key: cord-339195-aq3hb68r
authors: Falkenhain‐López, D.; Agud‐Dios, M.; Ortiz‐Romero, P.L.; Sánchez‐Velázquez, A.
title: COVID‐19‐related acute genital ulcers
date: 2020-06-26
journal: J Eur Acad Dermatol Venereol
DOI: 10.1111/jdv.16740
sha: 
doc_id: 339195
cord_uid: aq3hb68r

A wide variety of cutaneous manifestations has recently been reported as COVID-19-related skin lesions, such as erythematous rash, acro-ischemia or chilblain-like lesions 1, 2 , which can be useful for the clinical diagnosis of COVID-19. Case reports of other less frequent COVID-19-related skin disorders such as pytiriasis rosea 3 or livedo reticularis 4 have been also described. In order to report a new clinical manifestation of SARS-Coronavirus-2, we present a case of acute reactive genital ulcers in a COVID-19 patient.

Dear editor, A wide variety of cutaneous manifestations has recently been reported as COVID-19-related skin lesions, such as erythematous rash, acro-ischaemia or chilblain-like lesions, 1,2 which can be useful for the clinical diagnosis of COVID-19. Case reports of other less frequent COVID-19-related skin disorders such as pityriasis rosea 3 or livedo reticularis 4 have been also described. In order to report a new clinical manifestation of SARS Coronavirus 2, we present a case of acute reactive genital ulcers in a COVID-19 patient.

A 41-year-old otherwise healthy woman arrived at the emergency department with a 5-day history of painful genital ulcers. She presented also dry cough and rhinorrhoea for the last 10 days. Review of systems was negative except as noted above. The patient did not take any medication before the development of the lesions and denied any recent sexual risk behaviour. She had never presented genital ulcers before. There was no personal or familiar history of inflammatory bowel and/or autoimmune diseases.

Physical examination revealed two necrotic ulcers with raised, sharply demarcated borders in the inferior medial aspect of the right minor labia, with no evidence of 'kissing' lesions. A single oral aphtha was also observed ( Fig. 1 ). There was no cutaneous involvement.

Ulcer exudate bacterial culture and herpes simplex virus PCR were negative. Blood test showed no abnormalities in blood cell count, coagulation and biochemical parameters. Serologic testing for HIV, Epstein-Barr virus, cytomegalovirus and syphilis was negative. ANA and complement C3 and C4 levels were normal. The patient tested also negative for HLA-B51.

Treatment with prednisone 30 mg daily was initiated. One week later, the patient returned to our department referring improvement of the genital ulcers with pain reduction and complete resolution of the oral aphtha. Physical examination showed less severe erythema and disappearance of the necrotic eschar with a central fibrinous area (Fig. 2) . However, she presented worsening of the cough and a 3-day history of chest pain, lowgrade dyspnoea and dysthermia. Chest radiography was performed with no evidence of pneumonia. SARS Coronavirus 2 PCR was tested on nasopharyngeal swab with positive result, and a COVID-19 diagnosis with reactive acute genial ulcers (AGU) was made. 5 Genital ulcers evolved to resolution after one more week of corticosteroid treatment. Chest pain and dysthermia resolved with acetaminophen; cough and dyspnoea also showed improvement. No antibiotic or antiviral agents were required.

Acute genital vulvar ulcerations are non-sexually acquired lesions characterized by sudden onset of a few genital ulcers, presented typically in girls and young women. The terms AGU or Lipsch€ utz ulceration are used to describe ulcers associated with an immunologic reaction to a distant source of infection or inflammation. 6 The most common triggering factors are infectious diseases, specially flu-like and mononucleosis syndrome infections. 5, 7 In many cases, the patients present also other symptoms, mainly oral aphthae, malaise, lymphadenopathy or fever, 8 and concomitant cutaneous manifestations such as erythema nodosum can also be observed. 6 Therapies for AGU include anti-inflammatory drugs, topical anaesthetics and corticosteroids. When a triggering infection is documented, antimicrobial agents are also useful for the management of the ulcerations. The lesions commonly resolve within 3 weeks.

Some virus species have been well defined as triggering agents of Lipsch€ utz ulcers, specially Epstein-Barr virus. Although SARS Figure 1 Oral aphtha on the upper lip mucosa. Coronavirus 2 has been associated with oral ulcers, 9 we did not find previous reports of coronavirus-related AGU in the English literature. We report this case in order to describe a potential reactive dermatologic manifestation of the COVID-19. Moreover, we propose that Lipsch€ utz ulcers could be triggered by SARS Coronavirus 2, comparably to other respiratory virus infections.

Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases

Cutaneous manifestations in COVID-19: a first perspective

Pityriasis rosea as a cutaneous manifestation of COVID-19 infection

A dermatologic manifestation of COVID-19: transient livedo reticularis

Ulcus vulvae acutum Lipsch€ utz: a systematic literature review and a diagnostic and therapeutic algorithm

Lipschutz ulcers: evaluation and management of acute genital ulcers in women

Lipsch€ utz's acute vulvar ulcer: a systematic review

Non-sexually related acute genital ulcers in 13 pubertal girls: a clinical and microbiological study

Oral vesiculobullous lesions associated with SARS-CoV-2 infection

The patients in this manuscript have given written informed consent to the publication of their case details.
