








key: cord-283716-tleh9323
authors: Amatore, F.; Macagno, N.; Mailhe, M.; Demarez, B.; Gaudy‐Marqueste, C.; Grob, J.J.; Raoult, D.; Brouqui, P.; Richard, M.A.
title: SARS‐CoV‐2 infection presenting as a febrile rash
date: 2020-05-27
journal: J Eur Acad Dermatol Venereol
DOI: 10.1111/jdv.16528
sha: 
doc_id: 283716
cord_uid: tleh9323

The World Health Organization (WHO) has declared that Coronavirus disease 2019 (Covid-19) is a public health emergency of international concern as it continues to spread worldwide.1 After a median incubation period of 4 days, fever and cough are the two most common manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

The World Health Organization (WHO) has declared that Coronavirus disease 2019 (Covid-19) is a public health emergency of international concern as it continues to spread worldwide. 1 After a median incubation period of 4 days, fever and cough are the two most common manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. 2 Physicians worldwide are facing this new disease for which little is known about the full spectrum of its clinical features. For instance, some patients with Covid-19 associated cutaneous manifestation have been reported, but there is a lack of iconographic and histological documentation. [3] [4] [5] [6] [7] [8] [9] Herein, we describe a febrile rash as the only clinical manifestation of SARS-CoV-2 infection in a patient free from pulmonary symptoms.

On March the 7th this year, a 39-year-old Caucasian male with no relevant medical history presented to the emergency department with a fever of 39°C, along with a concomitant skin rash that had appeared the same day. This rash was characterized by erythematous and oedematous non-pruritic annular fixed plaques involving the upper limbs, chest, neck, abdomen and palms, sparing the face and mucous membranes ( Fig. 1a-e) . Importantly, the patient declared having taken no medication in the days and weeks before the onset of symptoms. His vitals were normal, and he had no signs of upper respiratory tract or pulmonary infection.

The patient promptly reported to the physician that he had been in contact 5 days earlier with a family member, who was afterwards tested positive for SARS-CoV-2. Quantitative reverse-transcriptase-polymerase-chain-reaction (qRT-PCR) assay performed on both nasopharyngeal swab and sputum sample revealed the presence of SARS-CoV-2 RNA. The search for other respiratory viruses, such as influenza A and B viruses, rhinovirus, and common coronaviruses was negative, as was the blood culture. Blood count, electrolytes, C-reactive protein and anti-DNA antibodies were normal too. The histological examination of the skin showed non-specific changes, compatible with viral exanthemata: predominantly superficial perivascular infiltrate of lymphocytes without eosinophils, papillary dermal oedema, subtle epidermal spongiosis, mild lymphocyte exocytosis, lichenoid and vacuolar interface dermatitis with occasional dyskeratotic keratinocytes in the basal layer (Fig. 1f) . No virally-induced cytopathic alterations or intranuclear inclusions were present. Direct immunofluorescence was negative.

Despite normal chest radiograph on admission, a chest CT scan showed bilateral and peripheral ground-glass and consolidative pulmonary opacities, highly suggestive of SARS-CoV-2 infection. 10 On March the 8th, the patient started oral hydroxychloroquine sulfate 200 mg three times per day for 10 days with a daily monitoring of SARS-Cov-2 qRT-PCR on nasopharyngeal swab. No pulmonary symptoms developed. On March the 14th, the rash fully recovered and laboratory tests for SARS-CoV-2 qRT-PCR became negative on March the 20th.

Our case report provides two important facts that need highlighting. Firstly, Covid-19 disease can present with a distinctive rash, which is histologically similar but clinically different to classic viral exanthemata. Indeed, the annular, polycyclic and circinate appearance of the skin lesions differed from classic paraviral rashes in adults, as did the papules on the palms. In addition, unlike viral infection-associated urticaria, the plaques were both fixed and non-pruritic. Secondly, a febrile rash may be the only clinical manifestation of Covid-19. As the outbreak spreads around the world, including in medically underdeveloped countries, choices will have to be made regarding which patients need to be tested or not for SARS-CoV-2. We suggest that patients presenting with a febrile rash during the current pandemic should be tested. Histological findings were unspecific but consistent with viral exanthemata: superficial perivascular lymphocytic infiltrate, papillary dermal edema, mild spongiosis, lichenoid and vacuolar interface dermatitis, dyskeratotic basilar eratinocytes, occasional neutrophils but no eosinophils within the dermal infiltrate.

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Cutaneous manifestations in COVID-19: a first perspective

COVID-19 can present with a rash and be mistaken for Dengue

A distinctive skin rash associated with Coronavirus Disease

Cutaneous manifestations in COVID-19: a new contribution

Viral exanthem in COVID-19, a clinical enigma with biological significance

Urticarial eruption in COVID-19 infection

COVID-19 and cutaneous manifestations

Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: a report of 1014 cases

The patient in this manuscript has given written informed consent to the publication of his case details.

