








key: cord-301744-rx7ywew5
authors: Kelleni, Mina T.
title: SARS CoV-2 viral load might not be the right predictor of COVID-19 mortality
date: 2020-08-15
journal: J Infect
DOI: 10.1016/j.jinf.2020.08.018
sha: 
doc_id: 301744
cord_uid: rx7ywew5

nan

In their recent correspondence, Pujadas et al. have reported SARS-CoV-2 viral load at diagnosis as an independent predictor of mortality. They've reported the Mean log10 viral load significantly differed between patients who were alive (n=807; mean log10 viral load 5·2 copies per mL [SD 3]) versus those who had died (n=338; 6·4 copies per mL [2·7]) by the end of the study period 1 . The author would like to argue the clinical significance of their findings as it's apparent from the standard deviation of their reported results that some patients have survived though their initial detected viral load has been like or above the mean viral load in the deceased group and vice versa. Noteworthy, a systematic review of literature has previously demonstrated that seven studies observed increases in SARS CoV-2 viral loads prior to clinical deterioration and vice versa, yet it's also reported other seven studies that found little to no difference in viral load between pre-symptomatic, asymptomatic and symptomatic patients 2 . In a trial to explain the apparent contradictory results found in different studies as well as the lack of a distinct boundary between the viral loads that might be associated with a higher mortality rate or a higher recover rate; the author would like to suggest that SARS CoV-2 viral load should be only considered as a personalized reflection to the immune response to COVID-19 as well as to the genetic polymorphisms in SARS CoV-2 receptors 3 . ACE2 polymorphisms might be a better field of study than SARS CoV-2 viral load wishing to develop a genetic test that might predict and exempt, if possible, from COVID-19 related duty those who are more vulnerable to complications and mortality 4 

SARS-CoV-2 viral load predicts COVID-19 mortality

SARS-CoV-2 detection, viral load and infectivity over the course of an infection

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

Hypothesis Article: COVID-19 unexplained mortality in the young adults: could it be due to ACE2 polymorphisms?



