        item: #1 of 149
          id: cord-007562-4hcs0z65
      author: Bijlenga, G.
       title: Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands
        date: 2005-07-19
       words: 1787
      flesch: 42
     summary: Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Induction of chicken interferon by avian infectious bronchitis virus The genome sequence of the SARSassociated coronavirus Specific cytotoxic T lymphocytes are involved in in vitro clearance of infectious bronchitis virus The carboxyl-terminal 120-residue polypeptide of infectious bronchitis virus nucleocapsid induces cytotoxic T lymphocytes and protect chickens from acute infection Cytotoxic T lymphocytes responses to infectious bronchitis virus infection Adoptive transfer of infectious bronchitis virus primed alphabeta T cells bearing CD8 antigen protects chicks from acute infection Mosaic evolution of the severe acute respiratory syndrome coronavirus Potential for polyvalent infectious bronchitis vaccines Study of protection by recombinant fowlpox expressing C-terminal nucleocapsid protein of infectious bronchitis virus against challenge 74250 La Tour-en-Faucigny, France Q 2005 key: cord-007562-4hcs0z65 authors: Bijlenga, G. title: Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands date: 2005-07-19 journal: J Infect DOI: 10.1016/j.jinf.2005.04.010 sha: doc_id: 7562 cord_uid: 4hcs0z65 nan Occult hepatitis B virus infection among anti-HBc positive blood donors: Necessitates substitution of screening by HBV NAT Safe blood transfusion still remains a major concern and so far all the efforts in this direction have failed to achieve zero residual risk of transfusion transmitted hepatitis B virus (HBV) infection.
    keywords: anti; blood; hbc; vaccine; virus
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        item: #2 of 149
          id: cord-007926-um2khqhn
      author: Zhang, Jiahao
       title: The continuous evolution and dissemination of 2019 novel human coronavirus
        date: 2020-02-22
       words: 958
      flesch: 40
     summary: Most of the patients infected with novel 2019-nCoV had a history to the seafood and live animal markets, and the vendor used to sale wild animal species, including marmot, snake, leopard cat, bamboo rat, badger, and hedgehog in Huanan seafood wholesale market (Supplementary Figure S4 ), all of which were susceptible to the novel CoV in nature, indicating that it remains likely there was intermediate hosts in the transmission cascade from bats to humans ( Fig. 2 ) . The 2019-nCoV circulating in USA and Wuhan, China clustered into an independent cluster.
    keywords: 2019; coronavirus; ncov; novel
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        item: #3 of 149
          id: cord-008671-k0vda7fy
      author: McCormack, J.G.
       title: Clinical features of rotavirus gastroenteritis
        date: 2005-04-14
       words: 2575
      flesch: 37
     summary: Upper respiratory tract infection (URTI) as a preceding or accompanying event in rotavirus gastroenteritis has been previously described in 29-42 per cent of cases ;2.6, la~ in one survey of gastroenteritis cases, patients with URTI were excluded. Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis At British Paediatric Association meetings, York Stool viruses in babies in Glasgow Rotaviruses of man and animals Importance ofa new virus in acute sporadic enteritis in children Asymptomatic endemic rotavirus infection in the newborn Rotavirus infections in adults in association with acute gastroenteritis Immunological response to human reovirus-like agent: measurement of anti-human reovirus-like agent IgG and IgM levels by the method of enzyme-linked immunosorbent assay Measurement of rotavirus antibody by an enzyme-linked immunosorbent assay-blocking assay Viruses and diarrhoea-a review Immunization of infants and young children against rotaviral gastroenteritis -prospects and problems, ff The clinical features of infantile gastroenteritis due to rotaviruseso A survey of rotaviruses associated with gastroenteritis in aboriginal children in Western Australia Comparison of human rotavirus disease in tropical and temperate settings Epidemiological aspects of rotavirus infection in hospitalized Venezuelan children with gastroenteritis Clinical features of acute gastroenteritis associated with human reovirus-like agent in infants and young children, ff Pediatr A study of the prevalence of rotavirus infection in children with gastroenteritis admitted to an infectious diseases hospital A clinical study of rotavirus gastroenteritis An investigation into the possible role of the family unit in the transmission of rotavirus infections of children The techniques of LA and CIE were used to seek cases of pneumococcal, meningococcal and H. influenzae meningites.
    keywords: cases; cent; gastroenteritis; group; rotavirus; study
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        item: #4 of 149
          id: cord-008672-luoxomif
      author: Mwachari, C.
       title: Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya
        date: 2004-10-29
       words: 3177
      flesch: 44
     summary: A significant association between colonization with adherent E. coli and chronic diarrhoea and wasting in AIDS patients has been demonstrated by Kotler et al., 19 who found such strains in 17% of study patients in the USA. ~ It is possible that novel agents remain to be characterized and associated with chronic diarrhoea and wasting in HIV patients, and HIV itself may be the cause of chronic diarrhoea in some patients.
    keywords: chronic; coli; culture; diarrhoea; hiv; patients; stool; study
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        item: #5 of 149
          id: cord-008676-35dgybwy
      author: Armero, Georgina
       title: Severe respiratory disease with rhinovirus detection: Role of bacteria in the most severe cases
        date: 2016-08-05
       words: 1440
      flesch: 40
     summary: Of them, 2/9 (22%) do not fulfilled the criteria of bacterial infection ( Table 2) . 10 For this reason, bacterial carriage and, moreover, bacterial infection must be considered when analyzing the severity of rhinovirus infection in comparison to other viruses, and it is often missed.
    keywords: bacterial; infection; patients
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        item: #6 of 149
          id: cord-008678-zi3aunqz
      author: Piñana, José Luis
       title: Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens
        date: 2020-01-10
       words: 2053
      flesch: 40
     summary: Detection or recovery of other microbial agents (one or more) was documented in 17 of the 27 specimens testing positive by PJ PCR ( Table 2 ). In our view, however, the variability in the performance of different PCR assays and sampling conditions, heterogeneity of patient populations, and in particular the lack of a PJ international standard material for PCR result normalization precludes defining a consensus universal threshold nowadays.
    keywords: diagnosis; patients; pcr; pjp; pneumonia; specimens
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        item: #7 of 149
          id: cord-008686-9ybxuy00
      author: Everett, Tom
       title: Poor transmission of seasonal cold viruses in a British Antarctic Survey base
        date: 2019-03-14
       words: 6934
      flesch: 48
     summary: The H1N1 and H3N2 subtypes of influenza virus are resistant to adamantanes (amantadine and rimantadine), and a small number of H1N1 strains have been found to be less sensitive to NA inhibitors (NAIs; oseltamivir, zanamivir, and peramivir). 3 Blood and saliva samples were sent to Viroscience for PCR testing to check for any residual SHBV, dengue, Chikungunya or Zika virus infections.
    keywords: cases; china; city; dengue; exposure; fever; h1n1; h7n9; human; influenza; outbreak; shbv; study; virus; viruses
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        item: #8 of 149
          id: cord-008695-y7il3hyb
      author: None
       title: Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic
        date: 2007-01-25
       words: 25930
      flesch: 41
     summary: London: Health Protection Agency The epidemiology and clinical impact of pandemic influenza The contribution of influenza to combined acute respiratory infections, hospital admissions, and deaths in winter Pandemic versus epidemic influenza mortality: a pattern of changing age distribution Delaying the international spread of pandemic influenza Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings Does this patient have influenza? Clinical signs and symptoms predicting influenza infection Predicting influenza infections during epidemics with use of a clinical case definition The predictive value of influenza symptomatology in elderly people Randomized, placebocontrolled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysis Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. Furthermore, the presence of an influenza-like illness (ILI) comprising of a combination of fever, cough, sore throat, myalgia and headache is not specific for influenza infection.
    keywords: acute; adults; antibiotic; bacterial; care; children; clinical; community; complications; days; disease; fever; hospital; illness; infection; influenza; influenza pandemic; management; oseltamivir; pandemic; patients; pneumonia; respiratory; therapy; treatment; virus
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        item: #9 of 149
          id: cord-010536-9ea7vvsz
      author: Chu, Yanan
       title: Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China
        date: 2020-04-28
       words: 919
      flesch: 44
     summary: In summary, our data indicate that SARS-CoV-2 infection might cause damage to the immune and liver function of COVID-19 patients. ECMO support was associated with improved ventilation conditions in COVID-19 patients with refractory hypoxemia.
    keywords: covid-19; ecmo; patients
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        item: #10 of 149
          id: cord-010540-0zkc5w74
      author: Lei, Pinggui
       title: Multiple parameters required for diagnosis of COVID-19 in clinical practice
        date: 2020-03-19
       words: 707
      flesch: 40
     summary: Significant statistical differences were observed in lymphocyte percentage decreased and C-reactive protein elevated (all P = 0.015) in the patients with COVID-19 infection between initial positive chest CT results (10/14) and negative chest CT results (4/14). We would like to share our opinions for diagnostic approach of COVID-19 infection, the diagnostic approach for COVID-19 infection should be made comprehensive analysis.
    keywords: covid-19; infection
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        item: #11 of 149
          id: cord-019964-9leljj8j
      author: None
       title: Recent research in infectious disease
        date: 2005-01-22
       words: 6121
      flesch: 44
     summary: We examined the risk of developing HSIL among adolescents with and without HIV infection. Methods: HIV-infected (nZ172) and-uninfected (nZ84) girls aged 13-18 years who were participating in a multicenter study of primarily horizontally acquired HIV infections in adolescents (Reaching for Excellence in Adolescent Health Care) and who did not have HSIL on cytologic examination at study entry or at the first follow-up visit were followed at 6-month intervals. Results: At the STI clinic (nZ756 men), we identified 150 men (20%) with Trichomonas vaginalis infection, 358 men (47%) with HIV infection, and 335 men (44%) with Neisseria gonorrhoeae infection.
    keywords: cases; children; group; gynecomastia; hiv; infected; infection; isolates; men; mrsa; patients; results; risk; study; use; virus; years
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        item: #12 of 149
          id: cord-019968-o5bdb37q
      author: Goldwater, Paul N.
       title: Gastroenteritis in Auckland: An aetiological and clinical study
        date: 2005-04-14
       words: 3585
      flesch: 44
     summary: The features of most cases of rotavirus gastroenteritis and non-rotavirus gastroenteritis were so similar that a separate aetiology for each group could not be distinguished on clinical evidence. On the whole, rotavirus gastroenteritis patients required intravenous fluids more often than the non-rotavirus group, but the numbers of patients in each group are small, Control patients had mainly respiratory infections and other non-diarrhoeal conditions.
    keywords: cent; control; diarrhoea; gastroenteritis; groups; non; particles; patients; rotavirus; stools
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        item: #13 of 149
          id: cord-019977-kj0eaw6v
      author: None
       title: Neonatal bacterial infection: A changing scene?
        date: 2005-04-14
       words: 1336
      flesch: 38
     summary: key: cord-019977-kj0eaw6v authors: nan title: Neonatal bacterial infection: A changing scene? date: 2005-04-14 journal: J Infect DOI: 10.1016/s0163-4453(82)91569-9 sha: doc_id: The risk therefore is ever present, and-at least where neonatal bacterial infection is concerned -its nature may be ever changing.
    keywords: enterocolitis; infection; neonatal; newborn
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        item: #14 of 149
          id: cord-019982-hyxrgamj
      author: Brookfield, D.S.K.
       title: Viruses demonstrated in children in Tanzania: Studies in diarrhoea and measles
        date: 2005-04-14
       words: 1908
      flesch: 54
     summary: There is evidence that measles virus may be found in the cells of the gut (Fraser and Martin, 1978) but there has been little investigation into its relationship to the associated diarrhoea which occurs in children with measles in the tropics. Studies in Europe have suggested that stool viruses are more common in autumn and winter (Flewett, Davies, Bryden and Robertson, 1974) .
    keywords: breast; children; measles; virus
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        item: #15 of 149
          id: cord-025481-ljs80v45
      author: Hu, Jianhua
       title: COVID-19 patients with hypertension have more severity condition, and ACEI/ARB treatment have no infulence on the clinical severity and outcome
        date: 2020-05-28
       words: 1019
      flesch: 36
     summary: Patients with hypertension had a lower rate of mild type (59.06% vs 86.39%, P=0.000), but had a higher rate of severe (26.17% vs 11.43%, P=0.001) and critical types (14.77% vs 2.04%, P=0.000) than patients without hypertension. Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan A Novel Coronavirus from Patients with Pneumonia in China Severe acute respiratory syndrome-related coronavirus: The species and its viruses -a statement of the Coronavirus Study Group Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges A pneumonia outbreak associated with a new coronavirus of probable bat origin Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.
    keywords: covid-19; hypertension; p=0.000; patients
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        item: #16 of 149
          id: cord-025482-9iy4fxd5
      author: Zhong, Yueyang
       title: COVID-19: Evidence of the Eye
        date: 2020-05-28
       words: 536
      flesch: 47
     summary: First, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause ocular manifestations. Ocular manifestations may present as the initial and the only symptoms of infection.
    keywords: covid-19; patients
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        item: #17 of 149
          id: cord-025980-85jbwmfv
      author: Iwasaki, Sumio
       title: Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva
        date: 2020-06-04
       words: 627
      flesch: 45
     summary: Saliva is a reliable tool to detect SARS-CoV-2 Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses Consistent detection of 2019 novel coronavirus in saliva Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study Saliva is more sensitive for SARS-CoV-2 detectionin COVID-19 patients than nasopharyngeal swabs. Nasopharyngeal swab and saliva samples were simultaneously collected from patients suspicious of COVID-19 and those with the diagnosis of COVID-19.
    keywords: nasopharyngeal; saliva
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        item: #18 of 149
          id: cord-026603-h4zy3244
      author: Gallo, Oreste
       title: “Is really the cancer population at risk for more severe COVID-19? Some hints from the cytokine profile”
        date: 2020-06-10
       words: 962
      flesch: 32
     summary: Our analysis was also the first, to the best of our knowledge, to directly compared COVID-19 cancer and non-cancer patients from both a clinical and immunological point of view. Dear Editor, we read with great interest the meta-analysis by Afshar and colleagues regarding the very high case-fatality rate in cancer patients infected with SARS-CoV-2.
    keywords: cancer; covid-19; patients
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        item: #19 of 149
          id: cord-027498-cfzfgzqi
      author: Hattori, Takeshi
       title: Older age is associated with sustained detection of SARS-CoV-2 in nasopharyngeal swab samples
        date: 2020-06-21
       words: 844
      flesch: 48
     summary: In our analysis, older age is significantly associated with prolonged duration of positive PCR tests from nasopharyngeal swab samples, irrespective of the disease severity and the used of medication ( Figure 1 ). We speculate that in older individuals, cell turnover is less robust and as such, clearance of virus from the nasopharynx is prolonged; these factors may lead to positive PCR tests that persist after acute disease has resolved.
    keywords: nasopharyngeal; pcr; samples
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        item: #20 of 149
          id: cord-030594-xhp8kin0
      author: None
       title: Dear the Editor,
        date: 2020-08-19
       words: 855
      flesch: 31
     summary: We examined associations between cholinesterase levels on admission and the severity, and mortality of patients with COVID-19 pneumonia, as well as the interaction between cholinesterase and the previously reported factors of severity and mortality. Our results demonstrate that the potential of cholinesterase levels and their interactions were significantly associated with severity and mortality in COVID-19 pneumonia patients.
    keywords: cholinesterase; patients; phase
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        item: #21 of 149
          id: cord-030636-wpjmwwpu
      author: None
       title: Dear Editor,
        date: 2020-08-19
       words: 996
      flesch: 38
     summary: Survival status and clinical data were compared with a control group of COVID-19 patients aged < 70 years (n=109). [4] [5] [6] Further, the majority of data at the moment available often originating from Chinese surveys where elderly patients accounted only for a very limited part of the total.
    keywords: clinical; covid-19; patients
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        item: #22 of 149
          id: cord-252980-1e28zj1d
      author: Zhang, Jiahao
       title: Insights into the cross-species evolution of 2019 novel coronavirus
        date: 2020-03-04
       words: 1046
      flesch: 45
     summary: Although the S amino acid identities of pangolin-origin coronavirus exhibited lower amino acid identities with bat/RaTG13, it was noteworthy that six amino acids associated with the receptor binding preference of human receptor angiotensin converting enzyme II-464 L, 495F, 502Q, 503S, 510 N, and 514Y (SARS-CoV-2 numbering)-in the pangolin/1 coronavirus were the same as that of SARS-CoV-2 ( Fig. 2 ), but were distinct from that of the bat-origin coronaviruses. Since its emergence in December 2019, a seventh member of the family of human coronavirus named SARS-CoV-2 was responsible for an outbreak of coronavirus disease in Wuhan, China.
    keywords: bat; cov-2; sars
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        item: #23 of 149
          id: cord-254512-dct045kl
      author: Chen, Libin
       title: Imported COVID-19 Cases Pose New Challenges for China
        date: 2020-04-10
       words: 687
      flesch: 52
     summary: Therefore, the conundrum regarding the control over overseas imported cases as well as the prevention of a second epidemic outbreak that is fast approaching is a problem that China needs to pay special attention to, especially after the first second-generation case imported from abroad had appeared. The first stage is the outbreak period (December 31, 2019 to February 29, 2020), which entailed the period from the first detection of cases to the peak of the epidemic which saw a rapid increase in the number of confirmed cases, and to the time when the growth rate slowed down to less than 200 new confirmed cases per day.
    keywords: china; epidemic
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        item: #24 of 149
          id: cord-254556-1zthrgy1
      author: Taylor, Sylvia
       title: Respiratory viruses and influenza-like illness: Epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample
        date: 2016-09-22
       words: 4554
      flesch: 45
     summary: Epidemiology of viral respiratory infections Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis Estimates of world-wide distribution of child deaths from acute respiratory infections Global burden of childhood pneumonia and diarrhoea Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Molecular diagnosis of respiratory virus infections The role of infections and coinfections with newly identified and emerging respiratory viruses in children Relative efficacy of AS03-adjuvanted pandemic H1N1 influenza vaccine in children: results of a controlled, randomized efficacy trial Prevalence and incidence of respiratory syncytial virus and other respiratory viral infections in children 6 months to 10 years of age with influenza-like illness enrolled in a randomized trial Comparison of the Luminex xTAG respiratory viral panel fast for diagnosis of respiratory virus infection The use of confidence or fiducial limits illustrated in the case of the binomial A simple method to calculate the confidence interval of a standardized mortality ratio (SMR) Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parentcollected specimens Clinical epidemiology of bocavirus, rhinovirus, two polyomaviruses and four coronaviruses in HIV-infected and HIV-uninfected South African children Epidemiology of respiratory viral infections in children enrolled in a study of influenza vaccine effectiveness Incidence and etiology of acute lower respiratory tract infections in hospitalized children younger than 5 years in rural Thailand Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors Viruses associated with acute respiratory infections and influenza-like illness among outpatients from the Influenza Incidence Surveillance Project Picornavirus, the most common respiratory virus causing infection among patients of all ages hospitalized with acute respiratory illness Respiratory viruses within homeless shelters in Marseille, France Human rhinoviruses and enteroviruses in influenza-like illness in Latin America Respiratory viral infections during the 2009e2010 winter season in Central England, UK: incidence and patterns of multiple virus co-infections Concurrent detection of other respiratory viruses in children shedding viable human respiratory syncytial virus Community-acquired pneumonia requiring hospitalization among US children All authors participated in the design, or implementation, or analysis and interpretation of the study results; as well as in the development of this manuscript.
    keywords: children; ili; incidence; influenza; prevalence; rhinovirus; study; trial; viruses
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        item: #25 of 149
          id: cord-254635-gtgahlqm
      author: Sun, Guanghao
       title: An infectious disease/fever screening radar system which stratifies higher-risk patients within ten seconds using a neural network and the fuzzy grouping method
        date: 2014-12-23
       words: 3642
      flesch: 49
     summary: Avian influenza A (H5N1) infection in humans Clinical review: primary influenza viral pneumonia Mortality associated with influenza and respiratory syncytial virus in the United States Pandemic flu: clinical management of patients with an influenza-like illness during an influenza pandemic Analysis of IR thermal imager for mass blind fever screening The use of infrared thermometry for the detection of fever Mass screening of suspected febrile patients with remotesensing infrared thermography: alarm temperature and optimal distance Field test studies of our infrared-based human temperature screening system embedded with a parallel measurement approach Fever screening during the influenza (H1N1-2009) pandemic at Narita International Airport A novel screening method for influenza patients using a newly developed non-contact screening system The self-organizing map Some methods for classification and analysis of multivariate observations A novel infection screening method using a neural network and k-means clustering algorithm which can be applied for screening of unknown or unexpected infectious diseases Fuzzy c-means clustering with spatial information for image segmentation Robust information gain based fuzzy c-means clustering and classification of carotid artery ultrasound images A robust fuzzy local information c-means clustering algorithm Since a neural network provides an efficient method of classifying multi-dimensional data, we have proposed a method that uses a neural network to distinguish influenza patients from normal control subjects.
    keywords: group; influenza; non; patients; screening
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        item: #26 of 149
          id: cord-255174-h1izji2g
      author: Wei, Yuan-Yuan
       title: Risk factors for severe COVID-19: evidence from 167 hospitalized patients in Anhui, China
        date: 2020-04-17
       words: 958
      flesch: 48
     summary: The mean age was 49.03 years in severe patients and 40.83 years in non-severe patients, with a significant difference (p=0.007). The prevalence of shortness of breath was 73.33% in severe patients, which was significantly greater than the 28.47% prevalence in non-severe patients (p<0.001).
    keywords: covid-19; patients; risk
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        item: #27 of 149
          id: cord-256633-vls23fu5
      author: Dimeglio, Chloé
       title: The SARS-CoV-2 seroprevalence is the key factor for deconfinement in France
        date: 2020-04-29
       words: 1338
      flesch: 58
     summary: We have designed a model for predicting the evolution of the SARS-CoV-2 epidemic in France, which is based on seroprevalence and makes it possible to anticipate the deconfinement strategy. We have developed a method for measuring how seroprevalence affects the deconfinement strategy in France.
    keywords: cov-2; sars; seroprevalence
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        item: #28 of 149
          id: cord-256808-lxlerb13
      author: Lim, W.S
       title: Hospital management of adults with severe acute respiratory syndrome (SARS) if SARS re-emerges—updated 10 February 2004
        date: 2004-06-02
       words: 2427
      flesch: 49
     summary: An abnormal CXR with changes consistent with SARS would require the patient to be re-classified as having Probable SARS and be managed accordingly (see Section 2). Please discuss the classification of SARS patients with the Health Protection Agency's Communicable Disease Surveillance Centre (CDSC)
    keywords: acute; guidelines; health; patients; sars; syndrome
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        item: #29 of 149
          id: cord-257489-ruf4rzxm
      author: Kee, Sae Yoon
       title: Influenza vaccine coverage rates and perceptions on vaccination in South Korea
        date: 2007-06-28
       words: 4107
      flesch: 40
     summary: Demographics, state of influenza vaccination, reasons for vaccination or non-vaccination and perceptions on vaccinations were asked by questionnaire. Having more information on influenza and vaccination as well as doctor's recommendation for vaccination appeared to be the most important modus operandi to encourage influenza vaccination among non-vaccinees.
    keywords: group; influenza; non; population; risk; vaccination; vaccine
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        item: #30 of 149
          id: cord-257732-3xuy6tbn
      author: Azzi, Lorenzo
       title: Saliva is a reliable tool to detect SARS-CoV-2
        date: 2020-04-14
       words: 3516
      flesch: 48
     summary: This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data. Indeed, LDH is commonly released during tissue damage, it can be associated to the lung damage that takes place in COVID-19 patients.
    keywords: cov-2; covid-19; patients; saliva; salivary; sars; values
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        item: #31 of 149
          id: cord-260247-akujsk0s
      author: Hamed, Ehab
       title: Rates of recurrent positive SARS-CoV-2 swab results among patients attending primary care in Qatar
        date: 2020-11-02
       words: 963
      flesch: 48
     summary: The rates for recurrent positive results are reported for the total recurrent positive (62) and the total study population, (63444). Current smoking status was highly prevalent among patients with recurrent positive results.
    keywords: results; study
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        item: #32 of 149
          id: cord-260925-puuqv6zk
      author: Wen, Feng
       title: Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2
        date: 2020-03-05
       words: 1176
      flesch: 49
     summary: First, the protein sequences of SARS-CoV-2 were compared with RaTG13, human SARS (NC_004718.3), bat SARS (DQ022305.2), and human MERS (NC_019843.3) by calculating the similarity in a given sliding window ( Fig. 1 A) . The sequences NC_004718.3 of SARS coronavirus 6 genes were utilized to define the protein products of SARS-CoV-2.
    keywords: cov-2; sars; sequences
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        item: #33 of 149
          id: cord-261240-osbk041e
      author: Bermejo-Martin, Jesús F
       title: Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection
        date: 2020-03-05
       words: 971
      flesch: 37
     summary: The existence of hyper-cytokinemia in COVID-19 patients with lymphopenia could indicate a poor control of the pathogen, as showed in severe patients infected with the 2009 Pandemic Influenza virus. As we recently reviewed in J Clin Med, endothelial dysfunction induces disassembly of intercellular junctions, endothelial cell death and blood-tissue barrier disruption, along with enhanced leukocyte adhesion and extravasation, which could contribute to explain the lymphopenia observed in severe COVID-19 patients [9] .
    keywords: covid-19; lymphopenia; patients
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        item: #34 of 149
          id: cord-261405-n05wjimk
      author: Lui, Grace
       title: Viral dynamics of SARS-CoV-2 across a spectrum of disease severity in COVID-19
        date: 2020-04-18
       words: 1161
      flesch: 50
     summary: 8 Secondly, viral loads in lower respiratory tract better reflected the temporal course of clinical progression in severe disease than upper respiratory tract samples. In severe/critical disease, monitoring should be performed using lower respiratory tract samples.
    keywords: disease; patients; samples; tract
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        item: #35 of 149
          id: cord-263671-2b54qfo7
      author: Soriano, María Cruz
       title: Low incidence of co-infection, but high incidence of ICU-acquired infections in critically ill patients with COVID-19
        date: 2020-09-19
       words: 984
      flesch: 37
     summary: These data are in agree Lansbury et al. and with others reports 1, 4 These findings support stopping empirical antibiotics in the vast majority of patients when COVID-19 infection is confirmed. However, it is important to remark that mortality in the subgroup of patients with co-infection was very high, with a mortality rate of 57.1% versus 21.1% in patient without co-infection (p = 0.033).
    keywords: icu; infection; patients
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        item: #36 of 149
          id: cord-264255-q5izs39f
      author: Chieochansin, Thaweesak
       title: Human bocavirus (HBoV) in Thailand: Clinical manifestations in a hospitalized pediatric patient and molecular virus characterization
        date: 2007-12-31
       words: 2679
      flesch: 41
     summary: Cloning of a human parvovirus by molecular screening of respiratory tract samples Complete coding sequence and phylogenetic analysis of human bocavirus (HBoV) Human bocavirus: prevalence and clinical spectrum at a children's hospital Detection of human bocavirus in Cannadian children in a 1 year study Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infection Human bocavirus infection The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Bocavirus infection in hospitalized children Human bocavirus in French children Human bocavirus infection among children Detection of human bocavirus in Japanese children with lower respiratory tract infection Epidermiology profile and clinical associations of human bocavirus and other human parvovirus Real-Time PCR assays for detection of bocavirus in human specimens Evidence of human coronavirus HKU1 and human bocavirus in Australian children Human bocavirus in hospitalized children Frequent detection of bocavirus DNA in German children with respiratory tract infections Human bocavirus and acute wheezing in children Human bocavirus: A novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand High prevalence of human bocavirus detected in young children with severe acute lower respiratory tract disease by use of a standard PCR protocol and a novel Real-Time PCR protocol Human bocavirus in Italian patients with respiratory diseases Human bocavirus in febrile children, the Netherlands Human bocavirus in Iranian children with acute respiratory infections Human bocavirus infection, people's republic of China Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized for lower respiratory tract infection Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Detection of bocavirus DNA in nasopharyngeal aspirates of a child with bronchiolitis Evaluation of PCR testing of ethanol-fixed nasal swab specimens as an augmented surveillance strategy for influenza virus and adenovirus identification Detection and characterization of new influenza B virus variants in 2002 Plasma endothelin-1 in infants and young children with acute bronchiolitis and viral pneumonia The incidence of HBoV infection in pediatric patients amounted to 6.62% with 40% co-infected with other respiratory viruses.
    keywords: bocavirus; children; gene; hbov; human; infection; samples; tract
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        item: #37 of 149
          id: cord-264285-1sne3ng1
      author: Sze, Shirley
       title: Letter to the Editor: Variability but not admission or trends in NEWS2 score predicts clinical outcome in elderly hospitalised patients with COVID-19
        date: 2020-05-29
       words: 1201
      flesch: 51
     summary: In our small pilot of elderly patients admitted to hospital with COVID-19, admission NEWS2 scores did not seem to be useful in predicting clinical outcomes. Secondly, there was no significant difference in the admission NEWS2 score and its components, between patients who died and those who survived, apart from systolic blood pressure.
    keywords: covid-19; patients; score
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        item: #38 of 149
          id: cord-264302-8vo5psgm
      author: Lu, Yue
       title: Social media WeChat infers the development trend of COVID-19
        date: 2020-04-10
       words: 1090
      flesch: 64
     summary: The outbreak of coronavirus disease 2019 (COVID-19)-An emerging global health threat The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health -The latest 2019 novel coronavirus outbreak in Wuhan, China Retrospective analysis of the possibility of predicting the COVID-19 outbreak from internet searches and social media data, China A pneumonia outbreak associated with a new coronavirus of probable bat origin With the popularity of the Internet and smartphones, the focus of social media is often a sign of these major epidemic diseases.
    keywords: covid-19; february; january
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        item: #39 of 149
          id: cord-265504-yq9wsugy
      author: Anim, Desmond Ofosu
       title: Water scarcity and COVID-19 in sub-Saharan Africa
        date: 2020-05-21
       words: 1147
      flesch: 41
     summary: Water scarcity reflects the lack of sufficient available water resources to meet demand of usage within a region whereas water stress refers to the inability to meet human and ecological demand for water. In this paper, we highlight the issues that characterize water services amid the COVID-19 pandemic in sub-Saharan Africa (SSA) and discuss avenues for improving water management during this pandemic and future infectious disease outbreaks.
    keywords: access; covid-19; ssa; water
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        item: #40 of 149
          id: cord-265772-diahoew3
      author: Zhang, Yue
       title: Genotype shift in human coronavirus OC43 and emergence of a novel genotype by natural recombination
        date: 2014-12-18
       words: 3954
      flesch: 47
     summary: These results support our hypothesis that recombination events occur among OC43 genotypes. Multiple alignment results were consistent with our phylogenetic analysis as the five distinct CN strains had lower nt identities with representatives of B, C and D genotypes than other genotype B strains had with the reference strain, including B_BE03 (97.6e98.7%), C_HK04-01 (97.6e99.1%) and D_HK11-01 (97.5e99.0%)
    keywords: analysis; genes; genotype; hcov; oc43; recombination; sequences; strains
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        item: #41 of 149
          id: cord-266033-gbx48scp
      author: Xu, Yu-Huan
       title: Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2
        date: 2020-02-25
       words: 3096
      flesch: 48
     summary: Mild patients (29 years) were significantly (P<0.03) younger than either common (44.5 years) or severe (54.7) and critically severe (65.7 years) patients, and common patients were also significantly (P<0.03) younger than severe and critically severe patients. Mild patients were significantly ( P < 0.03) younger than either common or severe and critically severe patients, and common patients were also significantly ( P < 0.03) younger than severe and critically severe patients.
    keywords: coronavirus; imaging; lesion; ncp; patients
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        item: #42 of 149
          id: cord-266036-qhlo99l7
      author: Axell-House, Dierdre B.
       title: The Estimation of Diagnostic Accuracy of Tests for COVID-19: A Scoping Review
        date: 2020-08-31
       words: 5764
      flesch: 36
     summary: A review of methods Using a combination of reference tests to assess the accuracy of a new diagnostic test Value of composite reference standards in diagnostic research Diagnostic test evaluation methodology: A systematic review of methods employed to evaluate diagnostic tests in the absence of gold standard -An update Food and Drug Administration CfDaRH. However, our scoping review also uncovered imperfect methods for estimating diagnostic test performance in the absence of a gold standard and demonstrate that the accuracy of these tests should be interpreted with caution.
    keywords: cov-2; pcr; reference; rrt; sars; standard; studies; table; test
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        item: #43 of 149
          id: cord-266455-rbblg4pu
      author: Poole, Stephen
       title: Rapid syndromic molecular testing in pneumonia: The current landscape and future potential
        date: 2019-12-03
       words: 4842
      flesch: 28
     summary: The unyvero P55 'sample-in, answer-out' pneumonia assay: a performance evaluation Respiratory multiplex polymerase chain reaction: an important diagnostic tool in immunocompromised patients Multiplex PCR performed of bronchoalveolar lavage fluid increases pathogen identification rate in critically ill patients with pneumonia: a pilot study Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia Geographical and temporal variation in the frequency and antimicrobial susceptibility of bacteria isolated from patients hospitalized with bacterial pneumonia: results from 20 years of the sentry antimicrobial surveillance program Viral infection in patients with severe pneumonia requiring intensive care unit admission Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (Re-sPOC): a pragmatic, open-label, randomised controlled trial Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza a H1N1pdm09 virus infection: a meta-analysis of individual participant data Early oseltamivir after hospital admission is associated with shortened hospitalization: a 5-Year analysis of oseltamivir timing and clinical outcomes National surveillance scheme for Legionnaires' disease in residents of England and Wales ReSyn-Plex: respiratory syndrome linked pathogens multiplex detection and characterization Biofire diagnostics -FilmArray The There is very little published data comparing different syndromic molecular pneumonia tests.
    keywords: antibiotics; care; clinical; culture; detection; panel; pathogens; patients; pneumonia; unyvero
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        item: #44 of 149
          id: cord-266564-imj1lcy9
      author: Liu, Yangli
       title: Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy
        date: 2020-03-05
       words: 699
      flesch: 45
     summary: Efforts should be taken to reduce the infection rate of SARS-CoV-2 both in pregnant and perinatal period, and more intensive attention should be paid to pregnant patients. Clinical manifestations of the pregnant COVID-19 patients in this study varied widely from asymptomatic to very severe, similar to previous report in non-pregnant patients [4] .
    keywords: patients; sars
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        item: #45 of 149
          id: cord-267621-oc8bw7ft
      author: Kevorkian, Jean-Philippe
       title: Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study
        date: 2020-09-01
       words: 1205
      flesch: 29
     summary: Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial COVID-19: consider cytokine storm syndromes and immunosuppression Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis Fluid management in ARDS Dexamethasone in hospitalized patients with COVID-19-Preliminary Report Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19 Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study COVID-19 in patients with heart failure: the new and the old epidemic Troponin Ic high-sensitivity (ng/mL) 18 11 In COVID-19 patients, viral shedding is elevated early then declines.
    keywords: corticosteroids; covid-19; furosemide; patients
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        item: #46 of 149
          id: cord-269389-x8i5x62v
      author: Gensini, Gian Franco
       title: The concept of quarantine in history: from plague to SARS
        date: 2004-04-12
       words: 3199
      flesch: 44
     summary: However, it has also put into discussion the real effectiveness of quarantine measures, for, precisely as for every other health intervention, quarantine has limits of application of which the medical and social community should be perfectly aware. Fact sheet: Isolation and Quarantine Simulating the effect of quarantine on the spread of the 1918-19 flu in central Canada Plague as a biological weapon: medical and public health management.
    keywords: century; concept; disease; europe; health; isolation; plague; quarantine
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        item: #47 of 149
          id: cord-270258-9vgpphiu
      author: Ko, Jae-Hoon
       title: Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients
        date: 2016-08-09
       words: 3461
      flesch: 38
     summary: World Health Organization Case definition and management of patients with MERS coronavirus in Saudi Arabia MERS-CoV outbreak in Jeddah e a link to health care facilities On estimating the relation between blood group and disease Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Treatment strategies for Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV), US CDC Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong White cell differential count and influenza A Thrombocytopenia in patients with severe acute respiratory syndrome (review) The clinical course of symptomatic MERS patients progressed serially: patients developed initial symptoms after a median 5-day incubation period (IQR 3.5e7.0), pneumonia after a median of 6 days from symptom onset (IQR 5.0e7.0), and respiratory failure after a median of 12 days from symptom onset (IQR 10.0e13.0).
    keywords: cov; development; factors; failure; mers; patients; pneumonia
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        item: #48 of 149
          id: cord-271957-osaycpe8
      author: Zuin, Marco
       title: Arterial hypertension and risk of death in patients with COVID-19 infection: systematic review and meta-analysis
        date: 2020-04-11
       words: 1197
      flesch: 38
     summary: We therefore perform a systematic review and meta-analysis to evaluate the risk of death in COVID-19 infection patients with and without HT. The association between the presence of HT and a poor outcome in COVID-19 patients was partially demonstrated in single analysis, but never into a meta-analysis [6, 9] .
    keywords: covid-19; patients; risk
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        item: #49 of 149
          id: cord-273751-61eeykj1
      author: Yang, Zhenwei
       title: The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis
        date: 2020-04-10
       words: 3009
      flesch: 45
     summary: A retrospective study showed that the vast majority of SARS patients received satisfactory results from the use of corticosteroids. The Lancet Respiratory medicine Role of glucocorticoids on inflammatory response in nonimmunosuppressed patients with pneumonia: a pilot study Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo Preexisting influenza-specific CD4 + T cells correlate with disease protection against influenza challenge in humans Effects of early corticosteroid treatment on plasma SARS-associated coronavirus RNA concentrations in adult patients Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients SARS: systematic review of treatment effects The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and metaanalysis Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis None.
    keywords: analysis; coronavirus; corticosteroids; patients; sars
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        item: #50 of 149
          id: cord-274558-1k7bi6ng
      author: Moiseev, Sergey
       title: Sex differences in mortality in the intensive care unit patients with severe COVID-19
        date: 2020-09-28
       words: 722
      flesch: 41
     summary: We investigated the sex-related differences in the occurrence of comorbidities and mortality rates in a nationwide study in 1522 consecutive patients with severe SARS-CoV-2 pneumonia who were admitted to intensive care unit (ICU) for respiratory support. The differences between mortality rates in males and females cannot be explained by comorbidities, given the divergent trends in the occurrence of chronic illnesses that may worsen survival in COVID-19 patients.
    keywords: covid-19; males; mortality
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        item: #51 of 149
          id: cord-276328-08ava9ni
      author: Kunutsor, Setor K.
       title: Hepatic manifestations and complications of COVID-19: A systematic review and meta-analysis
        date: 2020-06-21
       words: 461
      flesch: 21
     summary: Renal complications in COVID-19: A systematic review and meta-analysis Cardiovascular complications in COVID-19: A systematic review and meta-analysis Clinical course and mortality risk of severe COVID-19 Markers of liver injury and clinical outcomes in COVID-19 patients: A systematic review and meta-analysis Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis. (5, 6) Emerging data also suggests COVID-19 contributes to adverse hepatic manifestations such as acute hepatic injury.
    keywords: covid-19; injury
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        item: #52 of 149
          id: cord-276345-xsjh3766
      author: Arshad, Yasir
       title: Detection of SARS-CoV-2 in ophthalmic secretions in Pakistan: A preliminary report
        date: 2020-08-25
       words: 669
      flesch: 53
     summary: World Health Organization Declares COVID-19 a 'Pandemic COVID-19 CORONAVIRUS PANDEMIC COVID-19: Limiting the risks for eye care professionals Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV The severe acute respiratory syndrome coronavirus in tears SARS-CoV-2 in the ocular surface of COVID-19 patients. All 35 oropharyngeal swab samples were detected positive for SARS CoV-2, however out of total 35 conjunctival swab samples, 3(8.5%) were detected positive by using real-time RT-PCR.
    keywords: cov-2; sars
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        item: #53 of 149
          id: cord-276991-gv1k7u7j
      author: Zhang, Xu
       title: Strategies to trace back the origin of COVID-19
        date: 2020-04-08
       words: 747
      flesch: 46
     summary: Detection and profiling of antibodies against the novel coronavirus, in the sera of human individuals before December 2019, present in Wuhan hospital (the sera kept in the hospital during physical examination or medical treatment, especially fever clinic), might confer scopes to determine as when the event of viral transmission to human population had originally occurred, thus, unraveling its enigmatic origin. Emergence of SARS-like coronavirus poses new challenge in China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster A family cluster of SARS-CoV-2 infection involving 11 patients in Nanjing, China Novel coronavirus disease (Covid-19): the first two patients in the UK with person to person transmission A novel coronavirus outbreak of global health concern Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China The British Infection Association Emergence of SARS-like coronavirus in china: an update A pneumonia outbreak associated with a new coronavirus of probable bat origin Isolation and characterization of 2019-nCoV-like coronavirus from Malayan pangolins key: cord-276991-gv1k7u7j authors: Zhang, Xu; Chen, Xiaoyuan; Zhang, Zhipeng; Roy, Ayan; Shen, Yongyi title: Strategies to trace back the origin of COVID-19 date: 2020-04-08 journal: J Infect DOI: 10.1016/j.jinf.2020.03.032 sha: doc_id: 276991 cord_uid: gv1k7u7j nan The recent outbreak of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2, had raised great concern.
    keywords: coronavirus; human
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        item: #54 of 149
          id: cord-277705-6lgt2i7f
      author: Luan, Junwen
       title: A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2
        date: 2020-04-10
       words: 1152
      flesch: 55
     summary: In current study, we found RGD/KGD motif presents not only in S protein but also in its receptor ACE2. First, we performed sequence analysis of S proteins from SARS-CoV-2 (YP_009724390.1) and SARS-CoV (NP_828851.1).
    keywords: ace2; protein; sars
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        item: #55 of 149
          id: cord-277763-ihg3te63
      author: Moynan, David
       title: The role of healthcare staff COVID-19 screening in infection prevention & control
        date: 2020-06-25
       words: 655
      flesch: 34
     summary: The role of COVID-19 surveillance of asymptomatic HCW has recently been highlighted and may become increasingly pertinent with new infection waves 2,3 . key: cord-277763-ihg3te63 authors: Moynan, David; Cagney, Maura; Dhuthaigh, Aoife Ni; Foley, Margaret; Salter, Aisling; Reidy, Niamh; Reidy, Paul; de Barra, Eoghan; Fitzpatrick, Fidelma title: The role of healthcare staff COVID-19 screening in infection prevention & control date: 2020-06-25 journal: J Infect DOI: 10.1016/j.jinf.2020.06.057 sha: doc_id: 277763 cord_uid: ihg3te63 nan The current COVID-19 pandemic presents many unique challenges for occupational health medicine and infection prevention and control (IPC) in hospitals.
    keywords: covid-19; hcw; sars
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        item: #56 of 149
          id: cord-278225-d0gxb6bx
      author: Meng, Yifan
       title: Value and Challenges: Nucleic Acid Amplification Tests for SARS–CoV-2 in Hospitalized COVID-19 Patients
        date: 2020-04-30
       words: 901
      flesch: 48
     summary: The clinical sampling frequency for inpatients with COVID-19 should be Viral dynamics of SARS-CoV-2 across a spectrum of disease severity in COVID-19 Report from the American Society for Value of Diagnostic Testing for SARS-CoV-2/COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China COVID-19) Stability issues of RT-PCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19 Potential false-negative nucleic acid testing results for Severe Acute Respiratory Syndrome Coronavirus 2 from thermal inactivation of samples with low viral loads We would like to show our great respect to all the workers and volunteers in the fight against COVID-19, especially to the medical workers who work with the authors on the frontline. It has been emphasized that diagnostic testing for SARS-CoV-2 was an especially important tool in the diagnosis and management of patients with COVID-19.
    keywords: covid-19; patients; sars
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        item: #57 of 149
          id: cord-280188-gir0y1m1
      author: Wang, Yanqun
       title: Genetic characterization of human bocavirus among children with severe acute respiratory infection in China
        date: 2016-06-13
       words: 3027
      flesch: 44
     summary: These data indicated that the HBoV infection may play an important role among children with SARI, although co-infection of HBoV with other viruses was much higher than that of HBoV infection alone. However, prolonged shed periods of HBoV and high coinfection detection resulted in the on-going debate of the HBoV as the agent of SARI 19 ; In addition, the comprehensive research of HBoV genome among children with SARI were limited, especially in China.
    keywords: bocavirus; children; china; hbov; human; infection; sari; vp1
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        item: #58 of 149
          id: cord-280350-ay4cnzn5
      author: Chan, Jasper F.W.
       title: Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus
        date: 2013-10-03
       words: 5166
      flesch: 34
     summary: 73 Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic The emerging novel Middle East respiratory syndrome coronavirus: the knowns and unknowns Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV); announcement of the coronavirus study group Global alert and response: Middle East respiratory syndrome coronavirus (MERS-CoV) e update e as of 4 October Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features Genetic relatedness of the novel human lineage C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 Genetic characterization of Betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East Respiratory Syndrome Coronavirus Interspecies transmission and emergence of novel viruses: lessons from bats and birds Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Coronaviruses in bats from Mexico Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications on disease pathogenesis and clinical manifestation Human coronavirus EMC does not require the SARScoronavirus receptor and maintains broad replicative capability in mammalian cell lines Middle East respiratory syndrome coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Update: severe respiratory illness associated with middle East respiratory syndrome coronavirus (MERS-CoV) e Worldwide Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Family cluster of middle East respiratory syndrome coronavirus infections Hospital outbreak of middle East respiratory syndrome coronavirus A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case First cases of middle East respiratory syndrome coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Identification of influenza A nucleoprotein as an antiviral target Two years after pandemic influenza A/2009/H1N1: what have we learned? Avian influenza A H5N1 virus: a continuous threat to humans Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome The emergence of influenza A (H7N9) sixteen years after influenza A(H5N1) in humans: a tale of two cities Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Treatment of SARS with human interferons Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells Characterization of SARS-CoV main protease and identification of biologically active small molecule inhibitors using a continuous fluorescence-based assay Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin Mycophenolate mofetil: an update Identification of active antiviral compounds against a New York isolate of West Nile virus Mycophenolic acid inhibits replication of Japanese encephalitis virus The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells Antiviral or proviral action of mycophenolic acid in hepatitis B infection?
    keywords: acid; coronavirus; cov; east; human; interferon; mers; middle; ribavirin; sars; syndrome
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        item: #59 of 149
          id: cord-280544-1rhu478r
      author: Korte, Wolfgang
       title: SARS-CoV-2 IgG and IgA antibody response is gender dependent; and IgG antibodies rapidly decline early on
        date: 2020-08-25
       words: 822
      flesch: 35
     summary: Upon the first blood sampling (corresponding to the median of 5 weeks after the PCR test (95% CI 5-6 weeks)), 4·6%, 4·6% and 6·5% of participants have not developed measurable anti-SP IgG, anti-SP IgA or anti-NC IgG, respectively. We speculate that the overall course of anti-SP IgA (with no further decline despite IgG declining, Figure 1c ) as well as the sex specific differences with an early, pronounced peak in men and a subpopulation of men with significantly higher IgA titers than the remainder (figure 2c) may be the result of an ongoing infection, which needs further attention and clarification (previous work has shown that IgA has a protective role against influenza A 9 ).
    keywords: iga; igg; sars
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        item: #60 of 149
          id: cord-280829-juu8d60q
      author: Anathallee, Mohammad
       title: Emergency departments (EDs) in the United Kingdom (UK) are not prepared for emerging biological threats and bioterrorism
        date: 2006-06-09
       words: 2038
      flesch: 45
     summary: Table 1 shows the facilities and procedures in UK EDs for the management of infectious diseases patients. Major EDs range in size from small district general hospital EDs which see less than 25 000 patients per year to large inner-city EDs which see greater than 100 000 patients per year.
    keywords: eds; health; patients
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        item: #61 of 149
          id: cord-281130-9tawihti
      author: Schirinzi, Annalisa
       title: Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department
        date: 2020-11-02
       words: 1037
      flesch: 31
     summary: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Biomarker associated with COVID-19 disease progression Presepsin in risk stratification of SARS-CoV-2 patients Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients Multimer formation and ligand recognition by the long pentraxin PTX3: similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component Cellspecific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells Plasma long pentraxin 3 (PTX3) concentration is a novel marker of disease activity in patients with communityacquired pneumonia Laboratory abnormalities in patients with COVID-2019 infection Taste and Smell Disorders in COVID-19 In patients with community-acquired pneumonia (CAP), the plasma concentration of PTX3, but not CRP, was correlated with the severity of CAP based on the pneumonia severity index (PSI), CURB-65, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, and the length of hospital stay (7) .
    keywords: crp; patients; ptx3
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        item: #62 of 149
          id: cord-281753-neur9nmc
      author: Ji, Jingjing
       title: Early, low-dose, short-term methylprednisolone decreased the mortality in critical COVID-19 patients: a multicenter retrospective cohort study
        date: 2020-11-08
       words: 808
      flesch: 39
     summary: In all 107 critical type patients, 33 of them were not received MP treatment, 59 of them received MP treatment in 7 days after admission to hospital and 12 of them were received after 7 days. 3 patients received MP treatment, but the starting time were missed, and they were not enrolled in analysis.
    keywords: patients; study; treatment
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        item: #63 of 149
          id: cord-281984-en9825p9
      author: Wang, Shijie
       title: Neutrophil-to-lymphocyte ratio at admission is an independent risk factors for the severity and mortality in patients with coronavirus disease 2019
        date: 2020-09-24
       words: 716
      flesch: 43
     summary: key: cord-281984-en9825p9 authors: Wang, Shijie; Fu, Lingli; Huang, Kejie; Han, Jianglong; Zhang, Rui; Fu, Zhenming title: Neutrophil-to-lymphocyte ratio at admission is an independent risk factors for the severity and mortality in patients with coronavirus disease 2019 date: 2020-09-24 journal: J Infect DOI: 10.1016/j.jinf.2020.09.022 sha: doc_id: 281984 cord_uid: en9825p9 • The level of NLR at admission could be independent risk factors for the severe disease and the mortality of COVID-19. The predictive value of NLR for poor prognosis was more significant in patients without other potential risk factors.
    keywords: nlr; risk
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        item: #64 of 149
          id: cord-282053-ftjx29lw
      author: Luis García de GuadianaRomualdo
       title: Circulating levels of GDF-15 and calprotectin for prediction of in-hospital mortality in COVID-19 patients: a case series
        date: 2020-08-12
       words: 841
      flesch: 33
     summary: Higher blood levels of inflammatory biomarkers in blood, such as C-reactive protein (CRP), ferritin and D-dimer, have been reported as predictors of a poor outcome in COVID-19 patients 5 . In a recent study, calprotectin levels were significantly higher in COVID-19 patients who required mechanical ventilation, similarly to CRP 9 .
    keywords: covid-19; inflammation; patients
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        item: #65 of 149
          id: cord-282433-p6jl9gxf
      author: Tu, Xinyi
       title: Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection
        date: 2015-03-27
       words: 4620
      flesch: 35
     summary: 9 SARS-associated coronavirus Pathogenesis of severe acute respiratory syndrome Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection IL-12 RB1 genetic variants contribute to human susceptibility to severe acute respiratory syndrome infection among Chinese Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection Genetic variation of the human alpha-2-Heremans-Schmid glycoprotein (AHSG) gene associated with the risk of SARS-CoV infection Genetic susceptibility to infectious disease: Therefore, although the highly significant associations between CCL2 G-2518A and susceptibility to SARS-CoV infection were biologically plausible, and strengthened by our 4 independent caseecontrol studies, it remains interesting to investigate that whether there exist population-specific differences for this polymorphism to SARS susceptibility between Chinese and Europeans.
    keywords: ccl2; cov; genotype; infection; mbl; polymorphisms; risk; sars; susceptibility
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        item: #66 of 149
          id: cord-282499-baia5prj
      author: Lei, Pinggui
       title: The evolution of CT characteristics in the patients with COVID-19 pneumonia
        date: 2020-03-19
       words: 441
      flesch: 35
     summary: key: cord-282499-baia5prj authors: Lei, Pinggui; Fan, Bing; Yuan, Yingnan title: The evolution of CT characteristics in the patients with COVID-19 pneumonia date: 2020-03-19 journal: J Infect DOI: 10.1016/j.jinf.2020.03.014 sha: doc_id: 282499 cord_uid: baia5prj nan In that study, significant statistical differences were observed in CT features of peripheral involving central ( P = 0.028), consolidation ( P = 0.009), and thickened interlobular septa ( P = 0.040) between moderate ( n = 28) and sever/critically severe ( n = 13). Therefore, knowing the corresponding CT feature of COVID-19 pneumonia at different stages, which could be helpful to precisely diagnose and understand CT characteristics of the novel coronavirus pneumonia beyond the radiological findings itself.
    keywords: covid-19
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        item: #67 of 149
          id: cord-282821-qvtvpnrr
      author: Thijsen, Steven
       title: Elevated nucleoprotein-induced interferon-γ release in COVID-19 patients detected in a SARS-CoV-2 enzyme-linked immunosorbent spot assay
        date: 2020-06-12
       words: 787
      flesch: 50
     summary: A clinical retrospective study in Wuhan Dysregulation of immune response in patients with COVID-19 in Wuhan, China Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals Interestingly, in a recent published study by Grifoni et al.(5) SARS-CoV-2 epitope pools were used to probe CD4+ T cell responses.
    keywords: sars
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        item: #68 of 149
          id: cord-283758-0z3jwwby
      author: Rokadiya, S.
       title: COVID-19: Outcomes of patients with confirmed COVID-19 re-admitted to hospital.
        date: 2020-07-08
       words: 973
      flesch: 45
     summary: Age, sex, comorbidities, ethnicity and deprivation have all been shown to correlate with worse outcomes in patients with COVID-19, however the outcomes of hospitalised patients once discharged remains unknown [3] [4] [5] . The median age of the re-admission group was higher at 73 years (IQR 58 -82) compared to discharged patients of (429/729) in all COVID-19 patients and ethnicity was predominantly of Black, Asian or Minority Ethnic (BAME) background in both groups (absolute 62.5% discharged vs 57.1% re-admission)
    keywords: admission; covid-19; patients
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        item: #69 of 149
          id: cord-284853-6efhdogi
      author: Xie, Yun
       title: Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19
        date: 2020-04-10
       words: 1842
      flesch: 47
     summary: A brief perspective from the front line Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered,retrospective, observational study Hyperimmune IV Immunoglobulin Treatment: A Multicenter Double-Blind Randomized Controlled Trial for Patients With Severe Intravenous Immunoglobulin and Mortality in Pneumonia Patients With Septic Shock: An Observational Nationwide Study Immunoglobulin A Modulates Inflammatory Responses in an In Vitro Model of Pneumonia Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency Systematic Review of Treatment Effects Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): A review Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Dose of IVIG B.Time of IVIG C. Hospital length of stay D. ICU length of stay We thank the hospital staff for their efforts in recruiting patients. Our study demonstrated that IVIG treatment in COVID-19 patients with severe pneumonia can improve the patients' indicators within a short time and improve the treatment efficiency of the patients with high effectiveness.
    keywords: covid-19; ivig; patients; pneumonia
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        item: #70 of 149
          id: cord-284862-nhihxog0
      author: Kroemer, Marie
       title: COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severity
        date: 2020-08-25
       words: 1045
      flesch: 40
     summary: Specific T-cell responses for S, M and N proteins were simultaneously shown for 70.0% of severe pneumonia patients while only for 37.9% of mild illness patients (P=0.0191) (Fig. 1E) . key: cord-284862-nhihxog0 authors: Kroemer, Marie; Spehner, Laurie; Vettoretti, Lucie; Bouard, Adeline; Eberst, Guillaume; Floury, Sebastien Pili; Capellier, Gilles; Lepiller, Quentin; Orillard, Emeline; Mansi, Laura; Clairet, Anne-Laure; Westeel, Virginie; Limat, Samuel; Dubois, Maxime; Malinowski, Léa; Bohard, Louis; Borg, Christophe; Chirouze, Catherine; Bouiller, Kevin title: COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severity date: 2020-08-25 journal: J Infect DOI: 10.1016/j.jinf.2020.08.036 sha: doc_id: 284862 cord_uid: nhihxog0 Adaptive Immune responses generated by SARS-CoV-2 virus in convalescent patients according to disease severity remain poorly characterized.
    keywords: patients; pneumonia; responses
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        item: #71 of 149
          id: cord-285179-26ey3fm8
      author: Chan, Kwok-Hung
       title: Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests
        date: 2013-04-10
       words: 5283
      flesch: 43
     summary: A severe acute respiratory syndrome (SARS)-like disease due to a novel betacoronavirus, human coronavirus EMC (HCoV-EMC), has emerged recently. As with other highly pathogenic viruses which are capable of causing epidemics such as SARS coronavirus (SARS-CoV) and avian H5N1 influenza A virus, an animal source of the virus leading to interspecies jumping to humans is possible.
    keywords: acute; antibodies; antibody; coronavirus; emc; hcov; human; oc43; patients; sars; sera; titers
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        item: #72 of 149
          id: cord-286014-cc99e24x
      author: Jang, T.-N
       title: Severe acute respiratory syndrome in Taiwan: analysis of epidemiological characteristics in 29 cases
        date: 2003-11-05
       words: 3031
      flesch: 51
     summary: Among the patients, 10 (34.5%) had been to hospitals with known SARS outbreak, 6 (20.7%) were healthcare workers, 4 (13.8%) were household contacts, 4 (13.8%) were unknown, 3 (10.3%) had recently traveled to mainland China or Hong Kong, and 2 (6.9%) had social contact with SARS patients. However, when seven cases of SARS were reported among healthcare workers at Hospital A on April 22, 2003 , the incidence of SARS cases in Taiwan increased dramatically.
    keywords: cases; hospital; outbreak; patients; sars; syndrome; taiwan
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        item: #73 of 149
          id: cord-287030-xzothuf7
      author: Pigott, David C.
       title: Emergency department evaluation of the febrile traveler
        date: 2006-05-23
       words: 2184
      flesch: 35
     summary: In the rare situation where patients are suspected of harboring highly pathogenic illnesses such as hemorrhagic fever viruses, plague or anthrax, all specimens from such patients should be regarded as high risk. Freedman et al., in a recent review of GeoSentinel infectious disease surveillance data gathered on more than 17,000 patients from 30 sites worldwide, found that significant regional differences were noted among ill returned travelers.
    keywords: diseases; fever; infection; malaria; patients
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        item: #74 of 149
          id: cord-287823-avi14ee5
      author: Wong, Martin CS
       title: The potential impact of vulnerability and coping capacity on the pandemic control of COVID-19
        date: 2020-05-28
       words: 1055
      flesch: 36
     summary: Hence, further exploration of the association between country capacity and COVID-19 burden is needed based on other indicators. ) The European commission has developed an index for risk management named INFORM; • Two dimensions (vulnerability and lack of coping capacity) are relevant to COVID-19; • We examined if these dimensions were associated with COVID-19 pandemic control; • Higher vulnerability and poorer coping capacity were associated with poorer control; • Modifying these two dimensions might potentially mitigate COVID-19 pandemic control. 
    keywords: covid-19; pandemic; vulnerability
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        item: #75 of 149
          id: cord-288010-i9zrojoo
      author: Jia, Yuanyuan
       title: Characterization of eight novel full-length genomes of SARS-CoV-2 among imported COVID-19 cases from abroad in Yunnan, China
        date: 2020-05-15
       words: 1134
      flesch: 49
     summary: Phylogenetic analyses revealed that the six isolates, including one from France (YN_Im02), two from Spain (YN_Im01 and YN_Im03), and three from the United States (YN_Im06-08) were clustered as G clade with a high bootstrap value of 99%, one strain from Cambodia (YN_Im04) was grouped into S clade with a bootstrap value of 80%, and the remaining one from Sri Lanka was classified within other clade, a large unclassified sequences because lack the signature variants (Fig.1C) . 7 G clade containing D614G variant in S protein is predominant in Europe, V clade possessing G251V mutation in ORF3 is more common in Asia and Europe, and S clade having L84S substitution in ORF8 is move prevalent in North America.
    keywords: china; clade; covid-19; sars
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        item: #76 of 149
          id: cord-288366-xe3pxrhv
      author: Wellbelove, Zoe
       title: Comparing the 4C mortality score for COVID-19 to established scores (CURB65, CRB65, qSOFA, NEWS) for respiratory infection patients
        date: 2020-10-25
       words: 684
      flesch: 31
     summary: key: cord-288366-xe3pxrhv authors: Wellbelove, Zoe; Walsh, Chloe; Perinpanathan, Tanaraj; Lillie, Patrick; Barlow, Gavin title: Comparing the 4C mortality score for COVID-19 to established scores (CURB65, CRB65, qSOFA, NEWS) for respiratory infection patients date: 2020-10-25 journal: J Infect DOI: 10.1016/j.jinf.2020.10.015 sha: doc_id: 288366 cord_uid: xe3pxrhv nan Comparing the 4C mortality score for COVID-19 to established scores (CURB65, CRB65, qSOFA, NEWS) for respiratory infection patients We have taken great interest in Ying et al's comparison of CRB-65 and qSOFA for predicting intensive respiratory support in COVID-19 patients. This supports the findings of Knight et al 2 , which showed that the 4C mortality score outperformed existing scores in COVID-19 patients.
    keywords: mortality; score
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        item: #77 of 149
          id: cord-288814-1zayb21f
      author: Lu, Qing-Bin
       title: Comorbidities for fatal outcome among the COVID-19 patients: a hospital-based case-control study
        date: 2020-07-27
       words: 1383
      flesch: 38
     summary: From 18 January to 24 February 2020, 1138 confirmed COVID-19 patients consisting of 920 survivals and 218 deaths from three designated hospitals for COVID-19 treatment in Hubei province were included for analysis (Table S1 ). A clinical risk score to identify patients with COVID-19 at high risk of critical care admission or death: An observational cohort study WHO.
    keywords: comorbidities; effect; patients; risk
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        item: #78 of 149
          id: cord-289169-3u7qgxud
      author: Fang, Xiaowei
       title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1
        date: 2020-04-11
       words: 496
      flesch: 38
     summary: More severe patients were treated with corticosteroids, leading to inconsistent baseline data (i.e., age, comorbidities and laboratory findings) between patients receiving corticosteroids and those who did not. key: cord-289169-3u7qgxud authors: Fang, Xiaowei; Mei, Qing; Yang, Tianjun; Li, Lei; Wang, Yinzhong; Tong, Fei; Geng, Shike; Pan, Aijun title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 date: 2020-04-11 journal: J Infect DOI: 10.1016/j.jinf.2020.03.039 sha: doc_id: 289169 cord_uid: 3u7qgxud nan drugs and symptomatic therapies.
    keywords: data; patients
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        item: #79 of 149
          id: cord-289364-p31gt533
      author: AlFehaidi, Alanoud
       title: A case of SARS-CoV-2 re-infection
        date: 2020-10-25
       words: 967
      flesch: 48
     summary: Our case presented with symptoms, positive contact history and positive swab results with a timeline significantly longer than any reported case. Positive result does not necessitate the presence of infection and viral RNA shedding declines following the resolution of symptoms.
    keywords: pcr; results; sars
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        item: #80 of 149
          id: cord-290066-umthoftd
      author: Jia, Xingwang
       title: False Negative RT-PCR and False Positive Antibody Tests ——Concern and Solutions in the Diagnosis of COVID-19
        date: 2020-10-08
       words: 519
      flesch: 39
     summary: False negative RT-PCR and false positive antibody tests are a concern. We also identified five patients with false antibody results, who had nasopharyngeal carcinoma, colon cancer, duodenal carcinoma, diabetes, and diffuse bronchitis, respectively.
    keywords: antibody; sars
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        item: #81 of 149
          id: cord-290385-0smnl70i
      author: Chan, Jasper F.W.
       title: Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease
        date: 2016-03-03
       words: 8262
      flesch: 36
     summary: Domain III peptides from flavivirus envelope protein are useful antigens for serologic diagnosis and targets for immunization A single mutation in chikungunya virus affects vector specificity and epidemic potential Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans Biology of Zika virus infection in human skin cells Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus Zika virus infection of the central nervous system of mice Zika virus: further isolations in the Zika area, and some studies on the strains isolated Persistence of arboviruses and antiviral antibodies in vertebrate hosts: its occurrence and impacts Incubation periods of mosquito-borne viral infections: a systematic review Rapid risk assessment: Zika virus infection outbreak, French Polynesia Current Zika virus epidemiology and recent epidemics Zika virus outbreak Zika virus infection in man Zika virus infection, Cambodia Fatal Zika virus infection in girl with sickle cell disease, Colombia. Zika situation report e neurological syndrome and congenital anomalies Zika virus infection acquired during brief travel to Indonesia First case of Zika virus infection in a returning Canadian traveler Two cases of Zika fever imported from French Polynesia to Japan First case of laboratory-confirmed Zika virus infection imported into Europe Zika virus infection after travel to Tahiti Zika virus infection in a traveller returning to Europe from Brazil Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase Zika virus in an American recreational traveler Acute Zika virus infection after travel to Malaysian Borneo Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines Zika virus infection in a traveller returning from the Maldives Epidemiological alert e neurological syndrome, congenital malformations, and Zika virus infection.
    keywords: aedes; blood; cases; congenital; dengue; epidemic; fever; human; infection; microcephaly; mosquito; patients; syndrome; transmission; virus; virus infection; zika; zika virus; zikv; zikv infection
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        item: #82 of 149
          id: cord-291181-u2t20mgi
      author: Chin, Ken Lee
       title: Early signs that COVID-19 is being contained in Australia
        date: 2020-05-01
       words: 758
      flesch: 57
     summary: Case fatality from COVID-19 infection in Australia is between 0.4% to 3.0%. On this basis, case fatality from COVID-19 infection in Australia is presently between 0.4% to 3.0%.
    keywords: australia; covid-19; icu
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        item: #83 of 149
          id: cord-291561-sxvgue36
      author: Haixu, Liang
       title: Detection of 20 respiratory viruses and bacteria by influenza-like illness surveillance in Beijing, China, 2016–2018
        date: 2019-11-25
       words: 10308
      flesch: 45
     summary: Influenza viruses, other respiratory viruses and bacteria have been detected in patients with ILI (2-4). We found that 20 respiratory pathogens circulated in Beijing, China, and influenza virus, human rhinovirus (hRV) and mycoplasma (MP) were the major pathogens.
    keywords: 2019; asf; cases; china; disease; eculizumab; fever; fig; gene; getv; infection; influenza; meningococcal; patients; prophylaxis; recombination; sars; spread; strains; study; virus; viruses
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        item: #84 of 149
          id: cord-291750-4s93wniq
      author: Lv, Boyan
       title: Global COVID-19 fatality analysis reveals Hubei-like countries potentially with severe outbreaks
        date: 2020-04-14
       words: 1031
      flesch: 60
     summary: We collected data of the officially released cumulative numbers of confirmed cases and deaths (from 23 January to 13 March 2020) with respect to mainland China, epicenter of the outbreak (i.e., Hubei Province and Wuhan City), outside Hubei (in China) and outside Wuhan (in Hubei), as well as to typical countries reported with a substantial number of deaths including South Korea, Japan, Iran, Italy, USA, France and Spain ( Fig. 1 ) . ≈Italy > outside Wuhan ≈Spain ≈Japan ≈France > South Korea ≈outside Hubei.
    keywords: china; hubei; outside
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        item: #85 of 149
          id: cord-291960-1is0rv6c
      author: Piñana, José Luis
       title: Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
        date: 2019-02-21
       words: 5916
      flesch: 36
     summary: The assessment of the performance of quantitative CMV DNA PCR testing for the diagnosis of CMV pneumonia faces several difficulties including: (i) the low incidence of this clinical event, (ii) the lack of a normalized procedure for CMV DNA PCR testing on BAL fluids, (iii) the non-negligible possibility of miscategorization of pneumonia cases as either being causally linked or unrelated to CMV when using BAL fluid specimens, or even lung tissue material, for CMV diagnosis, 8 (iv) the persistence of a large variability of CMV DNA loads provided by different real-time PCR assays, 31 -33 despite their calibration to the WHO International Standard for CMV DNA 24 and, as already mentioned, (v) the relegation of virological procedures for CMV detection in clinical specimens. In 41 episodes, CMV DNA BAL detection occurred in the face of an ongoing episode of CMV DNAemia (including two episodes that occurred in the setting of autopsy-proven CMV pneumonitis), and isolately in the remaining 15 episodes.
    keywords: bal; cmv; cytomegalovirus; detection; dna; fluid; load; patients; pneumonia; specimens
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        item: #86 of 149
          id: cord-292201-e7k7gn9q
      author: Fodjo, Joseph Nelson Siewe
       title: Mass masking as a way to contain COVID-19 and exit lockdown in low- and middle-income countries
        date: 2020-07-17
       words: 1285
      flesch: 45
     summary: The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2 Advice on the use of masks in the context of COVID-19: interim guidance Rational use of face masks in the COVID-19 pandemic. Recent evidence supports a predominantly airborne transmission route for COVID-19, and strongly encourages face mask use in public to prevent inter-human transmission.
    keywords: covid-19; face; masks; use
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        item: #87 of 149
          id: cord-292451-2tpef19n
      author: Komiya, Kosaku
       title: The COVID-19 pandemic and the true incidence of tuberculosis in Japan
        date: 2020-07-07
       words: 398
      flesch: 32
     summary: However, whether or not the decline in tuberculosis incidence is actually due to these prevention measures, as with other respiratory infectious diseases, is unclear. 6 As such, the infection control measures enacted to prevent SARS-CoV-2 transmission a short time after the COVID-19 outbreak are not expected to influence the trend in tuberculosis incidence.
    keywords: covid-19; tuberculosis
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        item: #88 of 149
          id: cord-293714-s6ezxi5r
      author: Principi, Nicola
       title: The role of infection in Kawasaki syndrome
        date: 2013-04-18
       words: 6236
      flesch: 28
     summary: The value of isolated populations in genetic studies of allergic disease High incidence of angiotensin I converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm Polymorphism of angiotensin-1converting enzyme gene and Kawasaki disease Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease Common variants in CASP3 confer susceptibility to Kawasaki disease Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease The CCR5 (-2135C/T) polymorphism may be associated with the development of Kawasaki disease in Korean Children Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease Genetic polymorphisms in the CD40 ligand gene and Kawasaki disease Inflammatory gene polymorphisms and susceptibility to Kawasaki disease and its arterial sequelae Polymorphism of Fc gamma RIIa may affect the efficacy of gamma-globulin therapy in Kawasaki disease The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease The -590 C/T and 8375 A/G interleukin-4 polymorphisms are not associated with Kawasaki disease in Taiwanese children Interleukin 6 gene promoter polymorphism is not associated with Kawasaki disease The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease Influence of interleukin 18 promoter polymorphisms in susceptibility to Kawasaki disease in Taiwan Inducible and endothelial constitutive nitric oxide synthase gene polymorphisms in Kawasaki disease Increased frequency of alleles associated with elevated tumor necrosis factor-alpha levels in children with Kawasaki disease Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease Polymorphisms in the mannose-binding lectin gene as determinants of age-defined risk of coronary artery lesions in Kawasaki disease Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease Polymorphism of transmembrane region of MICA gene and Kawasaki disease Circulating matrix metalloproteinases and their inhibitors in patients with Kawasaki disease Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease Genetic analysis of MMP gene polymorphisms in patients with Kawasaki disease Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease A polymorphism in plasma platelet-activating factor acetylhydrolase is involved in resistance to immunoglobulin treatment in Kawasaki disease Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease Transforming growth factor-beta signaling pathway in patients with Kawasaki disease Polymorphisms of transforming growth factor-b signaling pathway and Kawasaki disease in the Taiwanese population Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki disease Analysis of tumor necrosis factor-alpha production and polymorphisms of the tumor necrosis factor-alpha gene in individuals with a history of Kawasaki disease Association between levels of TNF-alpha and TNF-alpha promoter -308 A/A polymorphism in children with Kawasaki disease Tumor necrosis factor-alpha levels and promoter polymorphism in patients with Kawasaki disease in Korea Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease Vascular endothelial growth factor gene haplotypes in Kawasaki disease Association of vascular endothelial growth factor C-634 g polymorphism in Taiwanese children with Kawasaki disease Lack of association of the vascular endothelial growth factor gene polymorphisms with Kawasaki disease in Taiwanese children ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease Identification of novel susceptibility loci for Kawasaki disease in a Han Chinese population by a genome-wide association study Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease A genome-wide association study identifies three new risk loci for Kawasaki disease Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis This review was supported by a grant from the Italian Ministry of Health (Bando Giovani Ricercatori 2007). A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan Current recommendations for the pharmacological therapy in Kawasaki syndrome and management of its cardiovascular complications Kawasaki syndrome: an intriguing disease with numerous unsolved dilemmas Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young Discrimination between incomplete and atypical Kawasaki syndrome versus other febrile diseases in childhood: results from an international registry-based study Kawasaki syndrome-like illness associated with infection caused by enterotoxin B-secreting Staphylococcus aureus Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease Lack of association between Kawasaki syndrome and infection with parvovirus B19, human herpesvirus 8, TT virus, GB virus C/hepatitis G virus or Chlamydia pneumoniae Emerging from obscurity: understanding pulmonary and extrapulmonary syndromes, pathogenesis and epidemiology of human Mycoplasma pneumonia infections Respiratory tract infections by Mycoplasma pneumoniae in children: a review of diagnostic and therapeutic measures Kawasaki disease with a concomitant primary Epstein-Barr virus infection Adenovirus type 2 isolated from a patient with fatal Kawasaki disease Kawasaki disease and parvovirus B19 infection in an adult HIV-1-infected patient Isolation of human herpesvirus-6 from an infant with Kawasaki disease Kawasaki disease associated with Klebsiella pneumoniae bacteremia and parainfluenza type 3 virus infection Kawasaki disease associated with measles virus infection in a monozygotic twin Association of rotavirus infection with Kawasaki syndrome Concomitant dengue hemorrhagic fever with Kawasaki disease Kawasaki disease associated with chickenpox: report of two sibling cases Kawasaki disease coincident with influenza A H1N1/09 infection Kawasaki syndrome and concurrent Coxsackie-virus B3 infection Kawasaki disease in England: ethnicity, deprivation, and respiratory pathogens Association between a novel human coronavirus and Kawasaki disease Detection of human bocavirus in children with Kawasaki disease Kawasaki disease and human bocavirus e potential association?
    keywords: associated; association; children; disease; gene; incidence; infection; kawasaki; kawasaki disease; patients; polymorphism; susceptibility; syndrome
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        item: #89 of 149
          id: cord-295074-fsbp4fky
      author: Broor, Shobha
       title: Rates of respiratory virus-associated hospitalization in children aged <5 years in rural northern India
        date: 2013-11-21
       words: 3904
      flesch: 26
     summary: We found that respiratory virus infections were associated with 40% of acute medical illness hospitalizations among children aged <5 years, and one in five children hospitalized for acute medical illness had RSV infection. Though respiratory viruses are thought to cause substantial morbidity globally in children aged <5 years, the incidence of severe respiratory virus infections in children is unknown in India where 20% of the world's children live.
    keywords: children; hospitalizations; influenza; rsv; study; virus; viruses; years
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        item: #90 of 149
          id: cord-298639-v9yg80jw
      author: Chen, Yuxin
       title: High SARS-CoV-2 Antibody Prevalence among Healthcare Workers Exposed to COVID-19 Patients
        date: 2020-06-04
       words: 3378
      flesch: 43
     summary: key: cord-298639-v9yg80jw authors: Chen, Yuxin; Tong, Xin; Wang, Jian; Huang, Weijin; Yin, Shengxia; Huang, Rui; Yang, Hailong; Chen, Yong; Huang, Aijun; Liu, Yong; Chen, Yan; Yuan, Ling; Yan, Xiaomin; Shen, Han; Wu, Chao title: High SARS-CoV-2 Antibody Prevalence among Healthcare Workers Exposed to COVID-19 Patients date: 2020-06-04 journal: J Infect DOI: 10.1016/j.jinf.2020.05.067 sha: doc_id: 298639 cord_uid: v9yg80jw Risk analysis revealed that wearing face mask could reduce the infection risk (odds ratio [OR], 0.127, 95% confidence interval [CI] 0.017, 0.968), while when exposed to COVID-19 patients, doctors might have higher risk of seroconversion (OR, 346.837, 95% CI 8.924, 13479.434), compared with HCWs exposed to colleagues as well as nurses and general service assistants who exposed to patients.
    keywords: cov-2; covid-19; hcws; infection; mask; patients; samples; sars
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        item: #91 of 149
          id: cord-299018-eo73yl4v
      author: Gandini, O.
       title: Serum Ferritin as an independent risk factor for Acute Respiratory Distress Syndrome in COVID-19 Patients in Rome Italy
        date: 2020-09-15
       words: 759
      flesch: 28
     summary: Conversely, D dimer, LDH and CRP increased only in the group of critical patients (group 3), being substantially stable in the other groups characterized by mild, moderate and severe disease ( fig. 2 , panel C, D, E) Multivariate logistic regression model adjusted for several disease-related risk factors at admission, including age, sex, NLR, DD, LDH, ferritin and CRP, demonstrated that serum ferritin resulted as an independent predictor of disease severity in COVID-19 patients (OR = 1,0048, 95% CI, 1,0029 to 1,0083, P < 0,001.). In this Journal, Zhi Lin and colleagues (1) recently reported that Chinese patients with severe Sars-CoV2 disease showed higher levels of serum ferritin than patients with not severe one, confirming data from other authors on Chinese (2) (3) and Caucasian populations (4) (5) .
    keywords: covid-19; ferritin; patients
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        item: #92 of 149
          id: cord-300038-1fjb6b8e
      author: Cantini, Fabrizio
       title: Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact
        date: 2020-04-23
       words: 1264
      flesch: 41
     summary: On this basis, we assessed the safety of baricitinib therapy combined with lopinavir-ritonavir in moderate COVID-19 pneumonia patients and we evaluated its clinical impact. These results were likely due to the rapid action of the drug and the short median interval of 6 days from symptoms-onset and therapy starting, The major limitations of this pilot study were its open-label design with no randomization and the low number of treated patients.
    keywords: baricitinib; covid-19; patients; therapy; treatment
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        item: #93 of 149
          id: cord-301491-frv4c5ny
      author: Ran, Jinjun
       title: The Ambient Ozone and COVID-19 Transmissibility in China: A Data-Driven Ecological Study of 154 Cities
        date: 2020-07-08
       words: 1159
      flesch: 47
     summary: To our best knowledge, this is the first study on the association of COVID-19 transmissibility with ambient ozone. Ambient ozone was associated in reducing COVID-19 transmissibility probably due to its virucidal activity and possible impact on host defense.
    keywords: covid-19; ozone
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        item: #94 of 149
          id: cord-301592-n5ns3m34
      author: Ivaska, Lauri
       title: Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection
        date: 2017-01-07
       words: 4145
      flesch: 42
     summary: Blood MxA levels were lower in virus positive patients at the follow-up visit (110 [70e218] mg/L; median [IQR]) than they were during the febrile pharyngitis episode (780 [180e1190] mg/L). Furthermore, an elevated blood MxA level, as a marker of type I or type III interferon production, demonstrated an active innate immune response against acute virus infection in the majority of patients with a detected virus.
    keywords: blood; children; gas; group; mxa; patients; pharyngitis; study; virus; viruses
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        item: #95 of 149
          id: cord-301744-rx7ywew5
      author: Kelleni, Mina T.
       title: SARS CoV-2 viral load might not be the right predictor of COVID-19 mortality
        date: 2020-08-15
       words: 374
      flesch: 34
     summary: Noteworthy, a systematic review of literature has previously demonstrated that seven studies observed increases in SARS CoV-2 viral loads prior to clinical deterioration and vice versa, yet it's also reported other seven studies that found little to no difference in viral load between pre-symptomatic, asymptomatic and symptomatic patients 2 . ACE2 polymorphisms might be a better field of study than SARS CoV-2 viral load wishing to develop a genetic test that might predict and exempt, if possible, from COVID-19 related duty those who are more vulnerable to complications and mortality 4 SARS-CoV-2 viral load predicts COVID-19 mortality SARS-CoV-2 detection, viral load and infectivity over the course of an infection ACE2 receptor polymorphism:
    keywords: load
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        item: #96 of 149
          id: cord-302855-wwg6x1df
      author: Ma, Jia
       title: Clinical characteristics and prognosis in cancer patients with COVID-19: A single center's retrospective study
        date: 2020-04-14
       words: 1143
      flesch: 49
     summary: key: cord-302855-wwg6x1df authors: Ma, Jia; Yin, Jing; Qian, Yu; Wu, Yuan title: Clinical characteristics and prognosis in cancer patients with COVID-19: 302855 cord_uid: wwg6x1df • We describe the demographics, clinical characteristics, and prognosis of cancer patients with COVID-19 infection.
    keywords: cancer; covid-19; patients
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        item: #97 of 149
          id: cord-303763-2784hze3
      author: Choi, Seong-Ho
       title: Risk factors for pandemic H1N1 2009 infection in healthcare personnel of four general hospitals
        date: 2011-05-01
       words: 3215
      flesch: 45
     summary: However, the estimated rate of this study (9.1%) simply suggest that influenza infection may be considerable among HCP during an influenza pandemic, with the data from several large centers rather than those of single centers. Therefore, these data show that there needs to be a higher level of suspicion for influenza infection and the easy availability of diagnostic tests during an influenza pandemic among HCP. HCP of a younger age or who have underlying chronic diseases were more frequently associated with ILI than those without.
    keywords: h1n1; hcp; ili; infection; influenza; pandemic
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        item: #98 of 149
          id: cord-303904-8ubm0kig
      author: Verhagen, Lilly M.
       title: Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
        date: 2013-06-22
       words: 5286
      flesch: 35
     summary: In Eñepa children high S. pneumoniae carriage rates associated with a poor nutritional status contribute to the development of ARTIs. S. pneumoniae colonization rates in mothers of control children were not significantly different from rates observed in mothers of cases (36% vs. 46%, p Z 0.72).
    keywords: acute; age; arti; carriage; children; colonization; infections; mothers; pneumoniae; study; years
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        item: #99 of 149
          id: cord-304176-yloqrblw
      author: Tunesi, S.
       title: Prescribing COVID-19 treatments: what we should never forget
        date: 2020-05-13
       words: 704
      flesch: 38
     summary: key: cord-304176-yloqrblw authors: Tunesi, S.; Bourgarit, A. title: Prescribing COVID-19 treatments: what we should never forget date: 2020-05-13 journal: J Infect DOI: 10.1016/j.jinf.2020.05.018 sha: doc_id: 304176 cord_uid: yloqrblw nan Prescribing COVID-19 treatments: what we should never forget S. Tunesi, A. Bourgarit Sorbonne Paris-Nord University (Paris 13), Bobigny, France; Inserm, UMR 1135 CIMI, Paris, France; APHP, HUPSSD, Internal medicine department, Bondy, France Authors equally contributed to write and edit this paper. PLoS ONE Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.
    keywords: covid-19; sars; treatment
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        item: #100 of 149
          id: cord-304787-fohgekp4
      author: Prazuck, Thierry
       title: Investigation of a family outbreak of COVID-19 using systematic rapid diagnostic tests raises new questions about transmission
        date: 2020-06-29
       words: 1130
      flesch: 55
     summary: We identified 3 independent index cases (residents #1, #9, #22) that infected 6 secondary cases: 2 in house A, none in house B and present were infected, although they had very closed contacts with their infected parents. Figure 1 shows distribution of residents in each house, kinship, confirmed COVID-19 cases and the temporal occurrence of each case.
    keywords: cov-2; house; resident
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        item: #101 of 149
          id: cord-305330-mklkugj5
      author: Moiseev, Sergey
       title: Cancer in intensive care unit patients with COVID-19
        date: 2020-05-28
       words: 490
      flesch: 42
     summary: We realize that our reassuring findings may be misleading, since we do not know the total number of cancer patients who contracted SARS-CoV-2 in Russia and cannot definitely conclude that malignancy did not worsen outcomes of COVID-19. However, our data suggest that other factors, such as older age and comorbidities, contribute significantly to the more severe course of SARS-CoV-2 infection in cancer patients.
    keywords: patients; sars
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        item: #102 of 149
          id: cord-305462-2wz1f6k6
      author: Beckham, J. David
       title: Respiratory viral infections in patients with chronic, obstructive pulmonary disease
        date: 2004-09-22
       words: 3218
      flesch: 34
     summary: Deaths: final data for 1999 Deaths: final data for Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease Severe exacerbations of COPD patients: the role of pulmonary infections Interactions between viruses and bacteria in patients with chronic bronchitis Impact of respiratory virus infection in patients with chronic chest disease Chronic airway disease: the infection connection Respiratory viral infections in adults with and without chronic obstructive pulmonary disease Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Impact of respiratory virus infections on persons with chronic underlying conditions Role of viruses in exacerbations of chronic obstructive pulmonary disease Community study of role of viral infections in exacerbations of asthma in 9-11 year old children Respiratory tract viral infections in inner-city asthmatic adults Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. 8 Respiratory viral infections were identified in 19% of COPD subjects with acute respiratory illness. Reverse-transcription polymerase chain reaction (RT-PCR) assays can identify respiratory virus infection missed by cell culture.
    keywords: copd; infections; patients; pcr; study; virus
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        item: #103 of 149
          id: cord-305583-p2jp5fiq
      author: Lalloo, David G.
       title: UK malaria treatment guidelines 2016
        date: 2016-02-12
       words: 9463
      flesch: 45
     summary: Severe falciparum malaria Geographical concentration of falciparum malaria treated in the UK and delay to treatment with artesunate in severe cases: an observational study Relation of the stage of parasite development in the peripheral blood to prognosis in severe falciparum malaria Intraleucocytic malaria pigment and prognosis in severe malaria Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria The pathophysiologic and prognostic significance of acidosis in severe adult malaria The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults The relationship between age and the manifestations of and mortality associated with severe malaria Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand Treatment of imported malaria in adults: a multicentre study in France Artemisininbased combination therapy for treating uncomplicated malaria Effectiveness of quinine versus artemetherelumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial Therapy of uncomplicated falciparum malaria in Europe: MALT Treatment of acute uncomplicated falciparum malaria with artemetherelumefantrine in nonimmune populations: a safety, efficacy, and pharmacokinetic study Atovaquoneeproguanil in the treatment of imported uncomplicated Plasmodium falciparum malaria: a prospective observational study of 553 cases Azithromycin for treating uncomplicated malaria Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUA-MAT): an open-label, randomised trial Artesunate versus quinine for treating severe malaria A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria Intravenous artesunate versus intravenous quinine in the treatment of severe falciparum malaria: a retrospective evaluation from a UK centre Artesunate versus quinine in the treatment of severe imported malaria: comparative analysis of adverse events focussing on delayed haemolysis Intravenous artesunate for severe malaria in travelers Delayed hemolysis after treatment with parenteral artesunate in African children with severe malariaea double-center prospective study Haemolysis associated with the treatment of malaria with artemisinin derivatives: a systematic review of current evidence Artemisinin resistance in Plasmodium falciparum malaria A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria A trial of artemether or quinine in children with cerebral malaria The Artemether-Quinine Meta-analysis Study Group. A metaanalysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria Quinine loading dose in cerebral malaria Plasma quinine concentrations in falciparum malaria with acute renal failure Management of severe malaria: interventions and controversies Fluid resuscitation of adults with severe falciparum malaria: effects on acid-base status, renal function, and extravascular lung water Hypoglycemia in African children with severe malaria Severe hypoglycemia and hyperinsulinemia in falciparum malaria Hemofiltration and peritoneal dialysis in infectionassociated acute renal failure in Vietnam Dexamethasone proves deleterious in cerebral malaria N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trial Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial High-dose dexamethasone in quininetreated patients with cerebral malaria: a double-blind, placebo-controlled trial Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: a meta-analysis Severe falciparum malaria: predicting the effect of exchange transfusion Manual blood exchange transfusion does not significantly contribute to parasite clearance in artesunate-treated individuals with imported severe Plasmodium falciparum malaria The diagnosis and treatment of malaria in pregnancy A systematic review of the safety and efficacy of artemetherelumefantrine against uncomplicated Plasmodium falciparum malaria during pregnancy Management of severe malaria in children: proposed guidelines for the United Kingdom Childhood malaria in East London Mortality after fluid bolus in African children with severe infection Proposed guidelines for severe imported malaria in children need more evidence Advanced paediatric life support: the practical approach Blood transfusion for treating malarial anaemia (Cochrane review) Efficacy and safety of artemisinin combination therapy (ACT) for non-falciparum malaria: a systematic review Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria Plasmodium vivax resistance to chloroquine? Chloroquine resistance in Plasmodium vivax.
    keywords: artesunate; blood; children; falciparum; falciparum malaria; grade; malaria; patients; plasmodium; primaquine; quinine; therapy; treatment; vivax
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        item: #104 of 149
          id: cord-307333-n6jc0jy3
      author: Selvaggi, Carla
       title: Interferon lambda 1–3 expression in infants hospitalized for RSV or HRV associated bronchiolitis
        date: 2014-01-02
       words: 6126
      flesch: 41
     summary: Therefore it is conceivable that the presence of reduced airway IFN lambda response in HRV infected infants than in those with RSV infections could reflect the presence of a milder bronchiolititis clinical course caused by HRV compared to that associated to RSV. This analysis could allow us to deep understand the complex picture of the airway IFN lambda response as well as the intensity and the dynamic nature of the antiviral and inflammatory pathways associated to type III IFN response during pediatric lower respiratory tract infections.
    keywords: bronchiolitis; expression; hrv; ifn; iii; infants; infection; lambda; levels; rsv; type
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        item: #105 of 149
          id: cord-308501-z3eiac25
      author: Zhu, Chengliang
       title: nBreastfeeding Risk from Detectable Severe Acute Respiratory Syndrome Coronavirus 2 in Breastmilk
        date: 2020-06-04
       words: 847
      flesch: 43
     summary: International journal of public health Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Clinical infectious diseases: an official publication of the Infectious Diseases Society of America SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infection. Although our conclusions are limited by the small sample size, we believe our findings are important for the concern of SARS-CoV-2 infection risk in breastfeeding of mother with COVID-19 to her neonate.
    keywords: cov-2; covid-19; sars
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        item: #106 of 149
          id: cord-308852-qdn04pun
      author: Lei, Hao
       title: Household transmission of COVID-19-a systematic review and meta-analysis
        date: 2020-08-25
       words: 1076
      flesch: 59
     summary: Here, we report a systematic review of household transmission studies of and try to assess the secondary attack rate of household COVID-19 transmission. key: cord-308852-qdn04pun authors: Lei, Hao; Xu, Xiaolin; Xiao, Shenglan; Wu, Xifeng; Shu, Yuelong title: Household transmission of COVID-19-a systematic review and meta-analysis date: 2020-08-25 journal: J Infect DOI: 10.1016/j.jinf.2020.08.033 sha: doc_id: 308852 cord_uid: qdn04pun • Infection risk of household contacts is 10 times higher than other contacts.
    keywords: household; sars; studies
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        item: #107 of 149
          id: cord-309294-ax6sr3zr
      author: Garrigues, Eve
       title: Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19
        date: 2020-08-25
       words: 1012
      flesch: 49
     summary: Except pain or discomfort, we found no significant difference regarding persistent symptoms and HRQoL between ward patients versus ICU patients. There was no statistically significant difference between ward and ICU groups, but there was a nonsignificant trend towards a reduced proportion of patients returning to work among ICU patients (46.7% versus 77.5%, P=0.061).
    keywords: covid-19; icu; patients
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        item: #108 of 149
          id: cord-309476-hel3h25h
      author: Brown, Julianne R.
       title: Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases
        date: 2018-01-02
       words: 5817
      flesch: 31
     summary: This approach has fundamental limitations, and contributes to the relatively high proportion of encephalitis cases that remain undiagnosed. key: cord-309476-hel3h25h authors: Brown, Julianne R.; Bharucha, Tehmina; Breuer, Judith title: Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases date: 2018-01-02 journal: J Infect DOI: 10.1016/j.jinf.2017.12.014 sha: doc_id: 309476 cord_uid: hel3h25h BACKGROUND: Current estimates suggest that even in the most resourced settings, the aetiology of encephalitis is identified in less than half of clinical cases.
    keywords: cases; csf; detection; diagnosis; encephalitis; infection; metagenomics; ngs; pathogen; sequencing; virus
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        item: #109 of 149
          id: cord-309577-438fotfd
      author: Xing, Yuhan
       title: Dynamics of faecal SARS-CoV-2 in infected children during the convalescent phase
        date: 2020-04-10
       words: 965
      flesch: 47
     summary: Evidence so far raises the possibility of faecal-oral transmission, reinforcing the need for nucleic acid testing of stool samples from COVID-19 patients during the convalescent phase. Dynamic profiles of real-time reverse transcription polymerase chain reaction (RT-PCR) results in throat swabs and faecal specimens were closely monitored till March 10, 2020, the final date of follow-up.
    keywords: cov-2; patients; sars
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        item: #110 of 149
          id: cord-310001-qng7h5cj
      author: Tomlins, Jennifer
       title: Clinical features of 95 sequential hospitalised patients with novel coronavirus 2019 disease (COVID-19), the first UK cohort
        date: 2020-04-27
       words: 1290
      flesch: 43
     summary: Numerous other case series of hospitalised patients in China have provided valuable insight into the clinical features of disease, risk factors for severity and case fatality rate. Coronavirus Disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up Clinical Characteristics of Coronavirus Disease 2019 in China Olfactory and gustatory dysfunctions as a clinical presentation of mild-tomoderate forms of the coronavirus disease (COVID-19): a multicenter European study Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia.
    keywords: care; days; disease; patients
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        item: #111 of 149
          id: cord-311766-m9yv4qkm
      author: Demey, Baptiste
       title: Dynamic profile for the detection of anti-SARS-CoV-2 antibodies using four immunochromatographic assays
        date: 2020-05-07
       words: 1756
      flesch: 44
     summary: Thus, immunochromatographic tests for the detection of anti-SARS-CoV-2 antibodies may have their place for the diagnostic panel of COVID-19. Thus, immunochromatographic tests for the detection of anti-SARS-CoV-2 antibodies may have their place for the diagnostic panel of COVID-19.
    keywords: cov-2; detection; sars; tests
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        item: #112 of 149
          id: cord-311853-k6efd9vg
      author: Lim, Rachel HF
       title: Decline in pneumococcal disease incidence in the time of COVID-19 in Singapore
        date: 2020-08-15
       words: 1256
      flesch: 37
     summary: key: cord-311853-k6efd9vg authors: Lim, Rachel HF; Chow, Angela; Ho, Hanley J title: Decline in pneumococcal disease incidence in the time of COVID-19 in Singapore date: 2020-08-15 journal: J Infect DOI: 10.1016/j.jinf.2020.08.020 sha: doc_id: 311853 cord_uid: k6efd9vg nan Chow et al reported a marked decline in influenza incidence in Singapore during the first four months of 2020, likely attributable to public health measures aimed at controlling the coronavirus disease 2019 (COVID-19) pandemic (1) . In conclusion, we observed a decreased incidence of pneumococcal disease at our institution that corresponded with the time period when public health measures were implemented to control COVID-19, suggesting that these measures had also had an inadvertent effect on the transmission of S. pneumoniae.
    keywords: covid-19; disease; measures
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        item: #113 of 149
          id: cord-312602-855n5av1
      author: Chen, Min
       title: Molecular identification of Cryptococcus gattii from cerebrospinal fluid using single-cell sequencing: a case study
        date: 2020-06-23
       words: 2662
      flesch: 44
     summary: These were derived from the genotype AFLP4/VGI representing C. gattii sensu stricto, which is the primary DNA of C. gattii sensu stricto in our study showed a close phylogenetic relationship with that of strain E566 originating from Australia. An otherwise healthy 31-year-old man with a 1-month history of intermittent fever showed that the pathogen belonged to C. gattii sensu stricto.
    keywords: cryptococcus; fungal; gattii; patient; scs; sensu; stricto
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        item: #114 of 149
          id: cord-312984-rzryn3on
      author: Pan, Daniel
       title: Serial simultaneously self-swabbed samples from multiple sites show similarly decreasing SARS-CoV-2 loads in COVID-19 cases of differing clinical severity
        date: 2020-09-19
       words: 951
      flesch: 43
     summary: However, this lower detection rate for conjunctival swabs (with or without overt conjunctivitis) is consistent with previous reports. [m5G Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility SARS-CoV-2 detection in different respiratory sites: a systematic review and meta-analysis Comparison of sputum and nasopharyngeal swabs for detection of respiratory viruses
    keywords: cov-2; covid-19; sars
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        item: #115 of 149
          id: cord-315300-v3pxb997
      author: Zhang, Haipeng
       title: CD4+T, CD8+T counts and severe COVID-19: A meta-analysis
        date: 2020-06-20
       words: 782
      flesch: 52
     summary: Therefore, we conducted this meta-analysis to investigate the relationship between CD4+T counts, CD8+T counts, CD4/CD8 ratio and the severity of COVID-19 patients. Both CD4+T and CD8+T counts significantly reduced in severe COVID-19 group compared with non-severe group [CD4+T (MD: -0.22×10 9 /L, 95%CI: -0.27 to -0.17×10 9 /L, I 2 =89%); CD8+T (MD: difference between two groups in CD4/CD8 ratio (MD: 0.17, 95%CI: -0.12 to 0.46, )
    keywords: counts; covid-19
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        item: #116 of 149
          id: cord-315723-unhg20e9
      author: Juan, Hui-Chun
       title: Decline in invasive pneumococcal disease during COVID-19 pandemic in Taiwan
        date: 2020-09-19
       words: 531
      flesch: 43
     summary: Although the collateral benefit of controlling COVID-19 for other common respiratory infectious diseases, such as influenza and tuberculosis in Taiwan have been demonstrated, 2 , 3 the impact of the infection control and policy to prevent COVID-19 outbreak on pneumococcal disease remained unclear. Although many confounding factors, such as vaccine strategy or under-report of IPD during COVID-19 pandemic were not evaluated in this study, our findings was consistent with Singapore's study 1 suggest that strictly performance of infection control and policy not only mitigate the threaten of COVID-19 but also reduce the burden of other respiratory infections disease -invasive pneumococcal diseases.
    keywords: covid-19; disease
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        item: #117 of 149
          id: cord-316501-fl2wvhia
      author: Noh, Ji Yun
       title: Asymptomatic infection and atypical manifestations of COVID-19: comparison of viral shedding duration
        date: 2020-05-21
       words: 446
      flesch: 40
     summary: key: cord-316501-fl2wvhia authors: Noh, Ji Yun; Yoon, Jin Gu; Seong, Hye; Choi, Won Suk; Sohn, Jang Wook; Cheong, Hee Jin; Kim, Woo Joo; Song, Joon Young title: Asymptomatic infection and atypical manifestations of COVID-19: comparison of viral shedding duration date: 2020-05-21 journal: J Infect DOI: 10.1016/j.jinf.2020.05.035 sha: doc_id: 316501 cord_uid: fl2wvhia • More than 25% of patients with COVID-19 were asymptomatic. Irrespective of clinical manifestations, all patients with COVID-19 showed prolonged viral shedding. to evaluate the prevalence of asymptomatic infection, anosmia (smell loss) and ageusia (taste 8 loss) among patients with mild COVID-19 in a residential treatment center (RTC).
    keywords: covid-19; patients
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        item: #118 of 149
          id: cord-317315-yyssvbbl
      author: Mao, Ming-Hui
       title: Serial semiquantitative detection of SARS-CoV-2 in saliva samples
        date: 2020-10-06
       words: 1085
      flesch: 49
     summary: The average time for nucleic acid detection results to become negative was 27.29±7.73 days for sputum samples, 27.82±12.09 days for oropharyngeal swab samples, and 24.53±13.59 days for saliva samples (see Appendix Table 4 ). In addition, to verify the specificity of saliva testing, the saliva and oropharyngeal swab samples of 50 patients were tested, and the results of all of these patients were negative.
    keywords: detection; saliva; sputum
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        item: #119 of 149
          id: cord-317846-str9i01o
      author: Chen, Dr. Xian
       title: Mesenchymal stem cell therapy in severe COVID-19: a retrospective study of short-term treatment efficacy and side effects
        date: 2020-05-15
       words: 1114
      flesch: 54
     summary: key: cord-317846-str9i01o authors: Chen, Dr. Xian; Shan, Yuheng title: Mesenchymal stem cell therapy in severe COVID-19: a retrospective study of short-term treatment efficacy and side effects date: 2020-05-15 journal: J Infect DOI: 10.1016/j.jinf.2020.05.020 sha: doc_id: 317846 cord_uid: str9i01o nan We read with interest the recent paper by Cantini et al., describing the safety and clinical impact of baricitinib therapy in Coronavirus disease 2019 (COVID-19) Hence, MSCs therapy may be a promising option for the treatment of severe COVID-19.
    keywords: covid-19; mscs; therapy
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        item: #120 of 149
          id: cord-318013-5om35tu8
      author: Marie, Tré-Hardy
       title: The role of serology for COVID-19 control: Population, kinetics and test performance do matter
        date: 2020-05-15
       words: 944
      flesch: 34
     summary: (1-4) The authors of these reports or correspondence highlighted the added value of serological testing, which, if captured within the correct timeframe after disease onset, can detect both active and past infections.(1) (6) In the near future, serological testing will be required to assess the effectiveness of vaccine candidates and finally, they are also useful to identify individuals who developed a strong immunological response to the virus and whose antibody isolates can be used to treat patients via plasma therapy.
    keywords: cut; igg; sensitivity
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        item: #121 of 149
          id: cord-318126-gg68o52z
      author: Zhou, Juan
       title: Observation and analysis of 26 cases of asymptomatic SARS-COV2 infection
        date: 2020-04-03
       words: 974
      flesch: 48
     summary: A total of 26 cases of asymptomatic infection were detected as SARS-COV2 positive through swab specimen between January 20 to February 30. CT check of lung in one case of asymptomatic infection.
    keywords: asymptomatic; cov2; sars
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        item: #122 of 149
          id: cord-320826-o6ih2f23
      author: Blairon, Laurent
       title: Large-scale, molecular and serological SARS-CoV-2 screening of healthcare workers in a 4-site public hospital in Belgium after COVID-19 outbreak
        date: 2020-07-31
       words: 868
      flesch: 45
     summary: High SARS-CoV-2 antibody prevalence among healthcare workers exposed to COVID-19 patients COVID-19 Bulletin épidémiologique du 10 avril COVID-19 diagnosis and management: a comprehensive review First experience of COVID-19 screening of health-care workers in England SARS-CoV-2-specific antibody detection in healthcare workers in Germany with direct contact to COVID-19 patients COVID-19 study: 8,4% of Belgian health workers have antibodies to SARS-COV-2 n The authors thank the general and medical managements of the Iris Hospital South for taking the lead on this massive screening; the Blood Sampling Centre, the technologists and administrative staff who contributed to the analytical, pre-analytical and post-analytical steps of the laboratory tests and all those who participated in this investigation. 320826 cord_uid: o6ih2f23 nan We read with great interest the study of Chen Y et al., who analyzed, during the Chinese epidemic peak, the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among 105 healthcare workers (HCWs) exposed to COVID-19 patients [1] .
    keywords: covid-19; hcws; sars
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        item: #123 of 149
          id: cord-321033-fusyx0t9
      author: None
       title: Follow-up study on pulmonary function and radiological changes in critically ill patients with COVID-19
        date: 2020-05-27
       words: 1238
      flesch: 46
     summary: The results of the older patient in this study, suggest that a proportion of severe COVID-19 patients developed fibrosis. Zhonghua liu xing bing xue za zhi = Correlation between Pneumonia Severity and Pulmonary Complications in Middle East Respiratory Syndrome Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 patients SARS: prognosis, outcome and sequelae Early rehabilitation for critically ill patients with COVID-2019: More benefits than risks We thank Dr Siu Kuanglok (Union Hospital, Hongkong, China) and Dr Zhechun Xu (Conch Hospital, Anhui, China) for helping with the interpretation of the chest CT scans.
    keywords: chest; illness; patients
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        item: #124 of 149
          id: cord-321989-1enjopig
      author: Li, Yanpeng
       title: Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia
        date: 2017-10-31
       words: 1490
      flesch: 52
     summary: Human bocavirus: current knowledge and future challenges Human rhinoviruses Respiratory viruses and influenza-like illness: epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample Genetic characterization of human bocavirus among children with severe acute respiratory infection in China Primary and secondary human bocavirus 1 infections in a family The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graftversus-host disease Fatal respiratory infections associated with rhinovirus outbreak Clinical and molecular epidemiology of human rhinovirus C in children and adults in Hong Kong reveals a possible distinct human rhinovirus C subgroup Clinical and molecular characterization of rhinoviruses A, B, and C in adult patients with pneumonia Guangzhou Women and Children's Medical Center Supplementary data related to this article can be found online at https://doi.org/10.1016/j.jinf.2017.10.012. key: cord-321989-1enjopig authors: Li, Yanpeng; Deng, Xilong; Hu, Fengyu; Wang, Jian; Liu, Ying; Huang, Huang; Ma, Jinmin; Zhang, Jianhui; Zhang, Fuchun; Zhang, Chiyu title: Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia date: 2017-10-31 journal: J Infect DOI: 10.1016/j.jinf.2017.10.012 sha: doc_id: 321989 cord_uid: 1enjopig • We first present a HRV-C and HBoV1 co-infection in an adult woman with severe acute respiratory distress syndrome.
    keywords: hbov1; hrv; infection
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        item: #125 of 149
          id: cord-322451-cwpz4akv
      author: Hsin, Dena Hsin-Chen
       title: Heroes of SARS: professional roles and ethics of health care workers
        date: 2004-07-27
       words: 3599
      flesch: 63
     summary: On the other hand, some suggested to punish those who were afraid of treating SARS patients. Most nurses and doctors actually died from taking care of SARS patients involuntarily.
    keywords: disease; health; hospital; patients; people; sars; taiwan
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        item: #126 of 149
          id: cord-322812-9u3ptqjs
      author: Wells, Philippa M.
       title: Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
        date: 2020-10-15
       words: 3734
      flesch: 45
     summary: Symptom profiling included core COVID-19 symptoms and general symptoms, in addition to algorithm prediction of prior COVID-19. Of 48 seropositive individuals with full symptom data, nine (19%) were fully asymptomatic, and 16 (27%) were asymptomatic for core COVID-19 symptoms: fever, cough or anosmia.
    keywords: anosmia; antibody; app; asymptomatic; covid-19; infection; participants; sars; study; symptoms
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        item: #127 of 149
          id: cord-327246-idmo5ds7
      author: M, Montero-Baladía
       title: Etoposide treatment adjunctive to immunosuppressants for critically ill COVID-19 patients: Etoposide for severe COVID-19 patients
        date: 2020-06-21
       words: 1409
      flesch: 30
     summary: Regarding oxygenation parameters, we observed that many severe COVID-19 patients presented with alarming PaO 2 /FiO 2 ratios (commonly under 150, see Table- 1) that, according to Berlin ARDS criteria, were immediate candidates for orotracheal intubation and mechanical ventilation. The currently ongoing clinical trial NCT04356690, started on May 8, 2020, will likely contribute to evaluate the safety and efficacy of etoposide in COVID-19 patients.
    keywords: avenida; covid-19; etoposide; islas; patients
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        item: #128 of 149
          id: cord-328068-qoz85x3r
      author: Alanio, Alexandre
       title: The presence of Pneumocystis jirovecii in critically ill patients with COVID-19
        date: 2020-11-04
       words: 1386
      flesch: 41
     summary: However, to the best of our knowledge, this is the first study evaluating the prevalence of P. jirovecii in COVID-19 patients. We found an unexpectedly high proportion of critically ill COVID-19 patients detected with P. jirovecii (10/108 patients; 9.3%), similarly to previous findings in influenza patients (3/45; ~7%).
    keywords: covid-19; jirovecii; patients
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        item: #129 of 149
          id: cord-328479-1tzysg7u
      author: Chen, Jianjun
       title: Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies in Pets in Wuhan, China
        date: 2020-06-21
       words: 724
      flesch: 47
     summary: In this study, we collected swab and blood samples from pet cats and dogs in Wuhan whose owners were confirmed to have COVID-19. Pet cats and dogs were recruited from COVID-19 patients admitted to Wuhan Jinyintan Hospital, one of the designated hospitals for COVID-19.
    keywords: cov-2; sars
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        item: #130 of 149
          id: cord-330387-7lci44w5
      author: Bird, Paul
       title: High SARS-CoV-2 infection rates in respiratory staff nurses and correlation of COVID-19 symptom patterns with PCR positivity and relative viral loads
        date: 2020-06-18
       words: 1294
      flesch: 44
     summary: key: cord-330387-7lci44w5 authors: Bird, Paul; Badhwar, Vinay; Fallon, Karlie; Kwok, Kin On; Tang, Julian W title: High SARS-CoV-2 infection rates in respiratory staff nurses and correlation of COVID-19 symptom patterns with PCR positivity and relative viral loads date: 2020-06-18 journal: J Infect DOI: 10.1016/j.jinf.2020.06.035 sha: doc_id: 330387 cord_uid: 7lci44w5 nan We read with interest the study in the Journal by Chen and colleagues from Nanjing, China that demonstrated a high positivity rate (17%) in healthcare workers (HCWs), 1 but did not attempt to breakdown which type of HCWs working in which specialties had the highest infection rates. A retrospective study in a single center in Wuhan Stay at Home guidance for households: current guidelines illustrated Recommended PPE for healthcare workers by secondary care inpatient clinical setting, NHS and independent sector Clinical evaluation of AusDiagnostics SARS-CoV-2 multiplex tandem PCR assay Is Ethnicity Linked to Incidence or Outcomes of covid-19? SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients Figure 1 A, B, C components:
    keywords: covid-19; hcws; pcr; sars
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        item: #131 of 149
          id: cord-331929-rot2vgso
      author: Piaserico, Stefano
       title: REPLY TO: Interleukin-17: a potential therapeutic target in COVID-19
        date: 2020-06-29
       words: 860
      flesch: 34
     summary: Moreover, anticoagulant therapies have been shown to ameliorate lung fibrosis in both murine models and human patients. In psoriatic patients, secukinumab has been demonstrated to decrease serum levels of Krebs von der Lungen-6 (KL6), a marker of lung fibrosis.
    keywords: covid-19; il-17; patients
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        item: #132 of 149
          id: cord-331931-2et3gcb5
      author: Zeng, Jie
       title: Clinical and Imaging features of COVID-19 Patients: Analysis of Data from High-Altitude Areas
        date: 2020-04-08
       words: 1200
      flesch: 55
     summary: We can also found the pleural effusion in COVID-19 patients, which was similar with previous research [8] , and the pleural effusion was completely absorbed after treatment. key: cord-331931-2et3gcb5 authors: Zeng, Jie; Peng, Shengkun; Lei, Yu; Huang, Jianxin; Guo, Yang; Zhang, Xiaoqin; Huang, Xiaobo; Pu, Hong; Pan, Lingai title: Clinical and Imaging features of COVID-19 Patients: Analysis of Data from High-Altitude Areas date: 2020-04-08 journal: J Infect DOI: 10.1016/j.jinf.2020.03.026 sha: doc_id: 331931 cord_uid: 2et3gcb5 nan SARS-CoV-2 has spread worldwide.
    keywords: covid-19; patients
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        item: #133 of 149
          id: cord-332786-7b6wz6i7
      author: Ha, Dat P.
       title: The stress-inducible molecular chaperone GRP78 as potential therapeutic target for Coronavirus infection
        date: 2020-06-12
       words: 1245
      flesch: 33
     summary: Beyond viral entry, GRP78 can play a major role in viral protein synthesis and maturation (Table 1) . In addition to its role in viral protein folding, GRP78 upregulation during viral replication could protect the virus-infected host cells from undergoing apoptosis since GRP78 is known to bind and maintain the ER-associated apoptotic machineries in their inactive forms and exert pro-survival effects especially under ER stress 3 .
    keywords: grp78; host; stress
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        item: #134 of 149
          id: cord-334443-3pyu8ucs
      author: He, Yu
       title: Public health might be endangered by possible prolonged discharge of SARS-CoV-2 in stool
        date: 2020-03-05
       words: 1018
      flesch: 45
     summary: About 27 percent of SARS patients have diarrhea and since full-length genome sequences identified that SARS-CoV-2 is 79.5% identical to SARS-CoV and share the same receptor angiotensin-converting enzyme 2 (ACE2), it is estimated that rate of gastrointestinal symptoms would be higher in patients with COVID-19 The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes Clinical Characteristics of Coronavirus Disease 2019 in China Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov Detection and monitoring of SARS coronavirus in the plasma and peripheral blood lymphocytes of patients with severe acute respiratory syndrome First case of neonate infected with novel coronavirus pneumonia in China The SARS epidemic in Hong Kong Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection Team TNCPERE
    keywords: cov-2; patients; sars
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        item: #135 of 149
          id: cord-335355-lcrbs2op
      author: Kunutsor, Setor K.
       title: Markers of liver injury and clinical outcomes in COVID-19 patients: A systematic review and meta-analysis
        date: 2020-05-28
       words: 1010
      flesch: 35
     summary: Taking the overall evidence together, the data supports a higher prevalence of elevated admission levels of markers of liver injury in severe or mortality due to COVID-19 disease, which suggests that patients with elevated levels of liver markers at baseline (during admission) had higher risks of developing worse outcomes in COVID-19. key: cord-335355-lcrbs2op authors: Kunutsor, Setor K.; Laukkanen, Jari A. title: Markers of liver injury and clinical outcomes in COVID-19 patients: A systematic review and meta-analysis date: 2020-05-28 journal: J Infect DOI: 10.1016/j.jinf.2020.05.045 sha: doc_id: 335355 cord_uid: lcrbs2op nan Since January 2020 when it was first isolated in China, coronavirus disease 2019 (COVID-19) has spread throughout the world and caused substantial morbidity and mortality.
    keywords: covid-19; injury; liver
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        item: #136 of 149
          id: cord-336591-a31oe7kc
      author: Wong, Martin
       title: Evaluation on different non-pharmaceutical interventions during COVID-19 pandemic: an analysis of 139 countries
        date: 2020-06-21
       words: 739
      flesch: 39
     summary: The findings of this study showed that more stringent containment and control measures could potentially lead to better COVID-19 pandemic control. Modelling SARS-COV2 Spread in London: Approaches to Lift the Lockdown Variation in Government responses to COVID-19 The 2019 Novel Coronavirus COVID-19 (2019-nCoV) data repository by Johns Hopkins Centre for Systems Science and Engineering (CSSE).
    keywords: countries; covid-19; stringency
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        item: #137 of 149
          id: cord-337557-ct43uoir
      author: Guetl, Katharina
       title: SARS-CoV-2 positive virus culture 7 weeks after onset of COVID-19 in an immunocompromised patient suffering from X chromosome-linked agammaglobulinemia
        date: 2020-10-27
       words: 856
      flesch: 35
     summary: Symptom-Based Strategy to Discontinue Isolation for Persons with COVID-19 Guidance for discharge and ending isolation in the context of widespread community transmission of COVID-19 -first update Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants CoV-2 shedding and mild course of COVID-19 in a patient after recent heart transplantation Virological assessment of hospitalized patients with COVID-2019 Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility X-Linked Agammaglobulinaemia: Lesson from patients with Agammaglobulinemia None to declare.
    keywords: covid-19; patient; sars
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        item: #138 of 149
          id: cord-337835-78i6j11i
      author: Alfaraj, Sarah H.
       title: The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus
        date: 2017-02-09
       words: 1534
      flesch: 56
     summary: 6 Only a small number of MERS cases had co-infection with influenza A, parainfluenza, herpes simplex, and Streptococcus pneumoniae. He denied history of travel or contact with positive case or camels.
    keywords: case; cov; infection; influenza; mers
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        item: #139 of 149
          id: cord-337854-5ogip9tz
      author: Huang, Wanqiu
       title: The determination of release from isolation of COVID-19 patients requires ultra-high sensitivity nucleic acid test technology
        date: 2020-07-02
       words: 1021
      flesch: 42
     summary: In our study, we developed an improved strategy, termed as nestRPA (nest recombinase polymerase amplification), which could greatly improve the sensitivity of nucleic acid detection for SARS-CoV-2 than RPA or qPCR. 4 Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients COVID-19 Testing: The Threat of False-Negative Results Negative Nasopharyngeal and Oropharyngeal Swabs Do Not Rule Out COVID-19 False-negative of RT-PCR and prolonged nucleic acid conversion in COVID-19:Rather than recurrence Estimating the extent of asymptomatic COVID-19 and its potential for community transmission: systematic review and meta-analysis Suboptimal biological sampling as a probable cause of false-negative COVID-19 diagnostic test results Understanding the Influence Factors in Viral Nucleic Acid Test of 2019 Novel Coronavirus (2019-nCoV) Expert consensus on specimen sampling technique of SARS-CoV-2 infected patients Expert consensus on nucleic acid detection of COVID-19 Antibody Detection and Dynamic Characteristics in Patients with COVID-19
    keywords: acid; covid-19; negative
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        item: #140 of 149
          id: cord-338333-yvm3d6xy
      author: Tu, Danna
       title: Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2
        date: 2020-07-25
       words: 1069
      flesch: 35
     summary: The results showed that Although we cannot clearly track antibody kinetics for asymptomatic infections, we can observe that the majority of participants with positive IgG antibodies had a significant decline in antibody levels after one month. key: cord-338333-yvm3d6xy authors: Tu, Danna; Shu, Junhua; Wu, Xiaoli; Li, Heng; Xia, Zhi; Zhang, Yanfang; Fang, Yaohui; Shen, Shu; Guan, Wuxiang; Wang, Hualin; Huang, Zhaoxuan; Wang, Guirong; Zhou, Xiaoqin; Deng, Fei title: Immunological detection of serum antibodies in pediatric medical workers exposed to varying levels of SARS-CoV-2 date: 2020-07-25 journal: J Infect DOI: 10.1016/j.jinf.2020.07.023 sha: doc_id: 338333 cord_uid: yvm3d6xy • Pediatric healthcare workers are at risk for SARS-CoV-2 transmission from children and aerosols increase SARS-CoV-2 infection rate.
    keywords: cov-2; covid-19; sars
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        item: #141 of 149
          id: cord-341754-rr7ei8o2
      author: Aitken, Tess
       title: Rethinking pandemic preparation: Global Health Security Index (GHSI) is predictive of COVID-19 burden, but in the opposite direction
        date: 2020-05-08
       words: 914
      flesch: 45
     summary: After adjusting for testing rate, median age and the proportion of females, a positive association was also observed between GHSI and COVID-19 cases and deaths, with the biggest burden borne by countries at the highest quartile of GHSI. We hypothesised that higher GHSI was inversely associated with measures of COVID-19 burden. Country-level data on COVID-19 as at 11 April 2020 were sourced from the 'worldometer'.
    keywords: countries; covid-19; ghsi
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        item: #142 of 149
          id: cord-346967-br4kpm6i
      author: Bongiovanni, Marco
       title: Acute hepatitis caused by asymptomatic COVID-19 infection
        date: 2020-09-03
       words: 926
      flesch: 36
     summary: Nevertheless, no data are available on liver enzyme abnormalities in asymptomatic subjects with COVID-19 infection. We report here the case of a young woman diagnosed with COVID-19 infection in absence of respiratory symptoms, presenting at the admission with significant elevation of liver function tests compatible with acute hepatitis.
    keywords: covid-19; infection; liver
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        item: #143 of 149
          id: cord-347280-jpwf55l6
      author: Skevaki, Chrysanthi
       title: Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus
        date: 2020-06-21
       words: 3076
      flesch: 30
     summary: Although patients with severe COVID-19 seem to have higher rates of liver dysfunction, it is reassuring that the levels of ALT, AST, TBIL, GGT in COVID-19 patients were not significantly different in compared with hospitalized community-acquired pneumonia patients and even the median or average transaminase level in severe COVID-19 patients was lower than twice upper reference limit 4, 36, 37 . key: cord-347280-jpwf55l6 authors: Skevaki, Chrysanthi; Fragkou, Paraskevi C.; Cheng, Chongsheng; Xie, Min; Renz, Harald title: Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus date: 2020-06-21 journal: J Infect DOI: 10.1016/j.jinf.2020.06.039 sha: doc_id: 347280 cord_uid: jpwf55l6 A subgroup of COVID-19 patients develop very severe disease with requirement for ICU treatment, ventilation, and ECMO therapy.
    keywords: cases; china; covid-19; disease; levels; patients; risk; sars; study
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        item: #144 of 149
          id: cord-348129-tph0d5fl
      author: De Deyn, Michelle Lee Zhi Qing
       title: A tale of two cities: a comparison of Hong Kong and Singapore's early strategies for the Coronavirus Disease 2019 (COVID-19)
        date: 2020-06-25
       words: 1147
      flesch: 42
     summary: After the 2003 severe acute respiratory syndrome-related coronavirus (SARS-CoV) outbreak, Singapore authorities had put in place a multi-ministry taskforce and a Disease Outbreak Response System Condition (DORSCON) framework that enables the whole-of-government to respond immediately to any disease outbreak and guide interventions 5 . The COVID (Temporary Measures) Act was passed by Singapore parliament on 7 April 2020, and under the act, the government has the powers to make regulations to further prevent or control the incidence or transmission of COVID-19.
    keywords: government; hong; kong; singapore
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        item: #145 of 149
          id: cord-350159-i2ig6dtr
      author: Daunt, Anna
       title: Validity of the UK Early Access to Medicines Scheme Criteria for Remdesivir use in patients with COVID-19 disease
        date: 2020-06-21
       words: 982
      flesch: 46
     summary: Early Access to Medicines Scheme for remdesivir in the treatment of COVID-19 Multi-Arm Therapeutic Study in Pre-ICU Patients Admitted with COVID-19 Early Epidemiological and Clinical Analysis of the First 200 Patients with COVID-19 Admitted via the Emergency Department in King's College Hospital A clinical risk score to identify patients with COVID-19 at high risk of critical care admission or death: an observational cohort study Clinical characteristics and predictors of outcomes of hospitalised patients with COVID-19 in a London NHS Trust: a retrospective cohort study An adapted version of the risk score, with twelve variables, was used to predict clinical deterioration (i.e. death or admission to critical care) in a cohort of 1,157 confirmed COVID-19 patients in one London NHS Trust.
    keywords: patients; risk; score
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        item: #146 of 149
          id: cord-350670-qk76szs0
      author: Vrsalovic, Mislav
       title: Cardiac injury and mortality in COVID-19: a reappraisal
        date: 2020-06-30
       words: 580
      flesch: 43
     summary: In conclusion, troponin positivity is common and has an independent prognostic role in hospitalised severe COVID-19 patients. key: cord-350670-qk76szs0 authors: Vrsalovic, Mislav; Presecki, Ana Vrsalovic title: Cardiac injury and mortality in COVID-19: a reappraisal date: 2020-06-30 journal: J Infect DOI: 10.1016/j.jinf.2020.06.068 sha: doc_id: 350670 cord_uid: qk76szs0 nan ng/mL, and >1 ng/mL), and the troponin cut-off (0.1 ng/mL) was approximately 5-6 times higher compared to other studies included in the meta-analysis.
    keywords: analysis; patients
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        item: #147 of 149
          id: cord-352111-frk319q1
      author: Woodruff, Amelita
       title: COVID-19 Follow up Testing
        date: 2020-05-11
       words: 634
      flesch: 54
     summary: • 70% of patients met CDC guidelines for release from quarantine & still tested (+); • The average time from onset of symptoms to negative testing was 19 days.  1 We provide care for COVID-19 patients in the outpatient setting through a virtual clinic.
    keywords: patients; test
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        item: #148 of 149
          id: cord-353608-de6rrf7v
      author: Saito, Sho
       title: First and second COVID-19 waves in Japan: A comparison of disease severity and characteristics: Comparison of the two COVID-19 waves in Japan
        date: 2020-11-02
       words: 983
      flesch: 47
     summary: However, the mortality was lower in second wave even if stratifying age and severity at admission. Earlier admission of patients in the second wave may reflect the increase in the number of PCR tests performed and the number of beds available to COVID-19 patients.
    keywords: admission; covid-19; patients; wave
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        item: #149 of 149
          id: cord-354612-7f91l0n9
      author: Villar, Livia Melo
       title: USEFULNESS OF SALIVA SAMPLES FOR DETECTING SARS-CoV-2 RNA AMONG LIVER DISEASE PATIENTS
        date: 2020-07-23
       words: 573
      flesch: 46
     summary: Saliva samples have been evaluated for SARS CoV-2 RNA detection in severe cases or hospitalized patients, but there is a lack of data about theses samples in mild cases or a standard protocol for sample collection and viral detection. This is the first report of SARS CoV-2 detection in saliva samples among liver disease patients showing best results until 7 days of beginning of symptoms.
    keywords: saliva; sars
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