# bib

id: cord-263363-2um8ntvi
author: de Havenon, Adam
title: Excess neurological death in New York City after the emergence of COVID-19
date: 2020-07-20
extension: .txt
mime: text/plain
words: 653
sentence: 30
flesch: 54
cache: cache/cord-263363-2um8ntvi.txt
txt: txt/cord-263363-2um8ntvi.txt
summary:
  During 03/21/20-05/30/20, COVID-19 deaths averaged 1578 a week, failing to account for the entirety of excess death. Figure 1b shows the concept of excess non-COVID deaths, which averaged 1670/week during 03/21/20-05/30/20.


id: cord-262598-zk192s0x
author: Tatu, Laurent
title: Guillain–Barré syndrome in the COVID-19 era: another occasional cluster?
date: 2020-06-23
extension: .txt
mime: text/plain
words: 703
sentence: 32
flesch: 47
cache: cache/cord-262598-zk192s0x.txt
txt: txt/cord-262598-zk192s0x.txt
summary:
  In our region, which spans the French-Swiss border, we have also been surprised by an abnormal number of GBS cases during the March-April 2020 period corresponding to the peak of the COVID-19 pandemic. In the public health crisis of March-April 2020, we encountered an unusually high number of GBS cases, admitting seven patients.


id: cord-312167-d16ylykc
author: Lazzarin, Serena Marita
date: 2020-11-03
extension: .txt
mime: text/plain
words: 840
sentence: 40
flesch: 35
cache: cache/cord-312167-d16ylykc.txt
txt: txt/cord-312167-d16ylykc.txt
title:
  Successful treatment of HIV-associated tumefactive demyelinating lesions with corticosteroids and cyclophosphamide: a case report

summary:
  However, in literature, no data are available for steroid-unresponsive TDLs in HIV patients [5] . Neuroradiological and pathological findings were suggestive of tumefactive demyelinating lesions (TDLs).


id: cord-270596-31g9hlm9
author: Bracaglia, Martina
date: 2020-06-25
extension: .txt
mime: text/plain
words: 707
sentence: 26
flesch: 32
cache: cache/cord-270596-31g9hlm9.txt
txt: txt/cord-270596-31g9hlm9.txt
title:
  Acute inflammatory demyelinating polyneuritis in association with an asymptomatic infection by SARS-CoV-2

summary:
  Potential neurological symptoms of COVID-19 Clinical features of patients infected with 2019 novel coronavirus in Wuhan Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Guillain-Barrè syndrome associated with Sars-CoV-2 Guillain-Barré syndrome following COVID-19: new infection, old complication? Guillain-Barré syndrome associated with SARS-CoV-2 infection Early Guillain-Barré syndrome in Coronavirus Disease 2019 (COVID-19): a case report from an Italian COVID-hospital Facial diplegia, a possible atypical variant of Guillain-Barré Syndrome as a rare neurological complication of SARS-CoV-2 Guillan-Barré syndrome associated with COVID-19 infection: A case report China medical treatment expert group for Covid-19. She was transferred to Covid-19 department and received a five days course of intravenous immune globulin (IvIg), ritonavir 100 mg and darunavir 800 mg per day with hydroxychloroquine 200 mg twice daily, according to our hospital protocol for COVID-19 treatment.


id: cord-325296-zrvykzof
author: Zuhorn, Frédéric
title: Parainfectious encephalitis in COVID-19: “The Claustrum Sign”
date: 2020-09-03
extension: .txt
mime: text/plain
words: 895
sentence: 43
flesch: 28
cache: cache/cord-325296-zrvykzof.txt
txt: txt/cord-325296-zrvykzof.txt
summary:
  MRI findings in COVID-19 encephalitis, especially when suggesting autoimmune encephalopathy may imply therapeutic interventions, such as immunosuppressive therapy. Recently, progressive clinical improvement along with a reduction of inflammatory CSF parameters has been observed in COVID-19 encephalitis, following high-dose steroid treatment


id: cord-338751-2eo7ityc
author: Anzalone, Nicoletta
title: Multifocal laminar cortical brain lesions: a consistent MRI finding in neuro-COVID-19 patients
date: 2020-06-06
extension: .txt
mime: text/plain
words: 1085
sentence: 48
flesch: 35
cache: cache/cord-338751-2eo7ityc.txt
txt: txt/cord-338751-2eo7ityc.txt
summary:
  Nonetheless, other vasculo-mediated mechanisms including altered vasomotor reactivity may play a role and cause neurological symptoms in COVID-19 patients [6] . In this regard, normalization of MRI findings in one patient (Fig. 2f-l) may corroborate the hypothesis of a transient functional nature of the impaired cerebral microcirculatory function.


id: cord-308288-3ewdy5l3
author: Domingues, Renan Barros
date: 2020-06-20
extension: .txt
mime: text/plain
words: 1165
sentence: 50
flesch: 42
cache: cache/cord-308288-3ewdy5l3.txt
txt: txt/cord-308288-3ewdy5l3.txt
title:
  First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease

summary:
  One possibility is that SARS CoV-2 infection is more persistent in the CNS, since it is a more immunoprivileged site. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2 Coronaviruses in brain tissue from patients with multiple sclerosis Acute and persistent infection of human neural cell lines by human coronavirus OC43 Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria Detection of antibodies to human coronaviruses 229E and OC43 in the sera of multiple sclerosis patients and normal subjects Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Multiple organ infection and the pathogenesis of SARS Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review


id: cord-302062-wqmynngg
author: Sierra-Hidalgo, Fernando
title: Large artery ischemic stroke in severe COVID-19
date: 2020-06-27
extension: .txt
mime: text/plain
words: 1147
sentence: 53
flesch: 41
cache: cache/cord-302062-wqmynngg.txt
txt: txt/cord-302062-wqmynngg.txt
summary:
  key: cord-302062-wqmynngg authors: Sierra-Hidalgo, Fernando; Muñoz-Rivas, Nuria; Torres Rubio, Pedro; Chao, Kateri; Villanova Martínez, Mercedes; Arranz García, Paz; Martínez-Acebes, Eva title: Large artery ischemic stroke in severe COVID-19 date: 2020-06-27 journal: J Neurol DOI: 10.1007/s00415-020-09967-1 sha: doc_id: 302062 cord_uid: wqmynngg nan The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly all around the world. Ischemic stroke occurred a median of 11.5 days after the onset of COVID-19 symptoms (interquartile range, IQR 2.8-16.3).


id: cord-257310-wqu7t44n
author: Maideniuc, Catalina
title: Acute necrotizing myelitis and acute motor axonal neuropathy in a COVID-19 patient
date: 2020-08-09
extension: .txt
mime: text/plain
words: 1099
sentence: 59
flesch: 47
cache: cache/cord-257310-wqu7t44n.txt
txt: txt/cord-257310-wqu7t44n.txt
summary:
  Repeat spinal fluid analysis demonstrated albuminocytological dissociation with elevated CSF protein (153 mg/dl) and normal white blood cell count (2/ mm 3 ), red blood cells (4 mm 3) , and glucose (79 mg/dl). The patient had a spinal fluid analysis that showed a hemorrhagic tap (red blood cells 312/mm 3 ) with normal white blood cells (3/mm 3) elevated protein (87 mg/ dl) and glucose (73 mg/dl).


id: cord-266135-jbc9nml0
author: Princiotta Cariddi, Lucia
title: Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient
date: 2020-06-24
extension: .txt
mime: text/plain
words: 1145
sentence: 57
flesch: 36
cache: cache/cord-266135-jbc9nml0.txt
txt: txt/cord-266135-jbc9nml0.txt
summary:
  This is the second report of hemorrhagic PRES in COVID-19, and these other two patients were very similar to ours. A reversible posterior leukoencephalopathy syndrome Posterior reversible encephalopathy syndrome in infection, sepsis, and shock Posterior reversible encephalopathy syndrome (PRES) and infection: a systematic review of the literature Posterior reversible encephalopathy in the intensive care unit Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome: clinical and radiological considerations Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions Hemorrhagic posterior reversible encephalopathy syndrome as a manifestation of COVID-19 infection Coronavirus disease 2019 (COVID-19) and cardiovascular disease: a viewpoint on the potential influence of angiotensin-converting enzyme inhibitors/ angiotensin receptor blockers on onset and severity of severe acute respiratory syndrome coronavirus 2 infection Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease?


id: cord-266923-hd1tjj6b
author: Padroni, Marina
title: Guillain-Barré syndrome following COVID-19: new infection, old complication?
date: 2020-04-24
extension: .txt
mime: text/plain
words: 1150
sentence: 45
flesch: 29
cache: cache/cord-266923-hd1tjj6b.txt
txt: txt/cord-266923-hd1tjj6b.txt
summary:
  WHO (2020) Coronavirus disease 2019 (COVID-19 Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study Guillain-Barré syndrome The electrodiagnosis of Guillain-Barré syndrome subtypes: where do we stand? Guillain-Barré syndrome associated with SARS CoV-2 infection: causality or coincidence Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing Toscana virus associated with Guillain-Barré syndrome: a case-control study Antiganglioside antibodies in neurological diseases Mimics and chameleons in Guillain-Barré and Miller Fisher syndromes Neurological complications during treatment of Middle East respiratory syndrome Future researches and data acquisition are needed to clarify the possible pathophysiological correlation, as well as to characterize the clinical/electrophysiological pattern of new cases of GBS observed in the context of COVID-19 pandemic.


id: cord-268572-uhak283t
author: Woo, Marcel S.
title: Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients
date: 2020-07-11
extension: .txt
mime: text/plain
words: 1308
sentence: 57
flesch: 43
cache: cache/cord-268572-uhak283t.txt
txt: txt/cord-268572-uhak283t.txt
summary:
  However, for individuals with B cell depletion uncertainty remains towards the robustness of viral control, the degree of immunity and risk of reinfection. She had a B cell count of 25/µL (Ref. 80-500/µL, Supplementary Table 2) at the day of admission and tested negative for SARS-CoV-2-specific antibodies (3.5 AU/mL; Ref. < 15 AU/mL) on April 7th, 2020, which converted to detectable antibodies on April 29th, 2020 (71.5 AU/mL).


id: cord-334814-stswaiep
author: Vogrig, Alberto
title: Causality in COVID-19-associated stroke: a uniform case definition for use in clinical research
date: 2020-08-01
extension: .txt
mime: text/plain
words: 1489
sentence: 72
flesch: 40
cache: cache/cord-334814-stswaiep.txt
txt: txt/cord-334814-stswaiep.txt
summary:
  Even if the World Health Organization (WHO) has provided definition for suspected, probable, and confirmed COVID-19 cases, we believe that only patients with laboratory-confirmed SARS-CoV-2 should enter in the classification, in addition to clinic-radiological evidence of acute stroke (ischemic or hemorrhagic). This example suggests that the CAS criteria can be useful in identifying stroke cases more likely to be causally linked to COVID-19, irrespective of where the infection was acquired.


id: cord-331423-5wpx0bd0
author: Pelea, Teodor
title: SARS-CoV-2 associated Guillain–Barré syndrome
date: 2020-08-08
extension: .txt
mime: text/plain
words: 2176
sentence: 107
flesch: 47
cache: cache/cord-331423-5wpx0bd0.txt
txt: txt/cord-331423-5wpx0bd0.txt
summary:
  A remarkable clinical pattern in our case was that there was bilateral peripheral facial nerve palsy. Facial nerve involvement in GBS is a common finding in 27-50% [12] .


id: cord-338928-y5l7cf31
author: Leonardi, Matilde
title: Neurological manifestations associated with COVID-19: a review and a call for action
date: 2020-05-20
extension: .txt
mime: text/plain
words: 2113
sentence: 85
flesch: 30
cache: cache/cord-338928-y5l7cf31.txt
txt: txt/cord-338928-y5l7cf31.txt
summary:
  Reports from China describe neurological symptoms in COVID-19 patients with one retrospective case series from Wuhan, China showing 78 of 214 patients (36%) with neurological manifestations Respiratory distress is the most distinctive symptom (55%) reported in COVID-19 patients [7] .


id: cord-340468-3s3dv88w
author: Plumereau, Cécile
date: 2020-09-09
extension: .txt
mime: text/plain
words: 2159
sentence: 98
flesch: 51
cache: cache/cord-340468-3s3dv88w.txt
txt: txt/cord-340468-3s3dv88w.txt
title:
  Effect of the COVID-19 pandemic on acute stroke reperfusion therapy: data from the Lyon Stroke Center Network

summary:
  Emergency Department and Out-of-Hospital Emergency System (112-AREU 118) integrated response to Coronavirus Disease 2019 in a Northern Italy centre Forgotten key players in public health: news media as agents of information and persuasion during the COVID-19 pandemic Impact of the COVID-19 epidemic on stroke care and potential solutions Acute stroke management pathway during Coronavirus-19 pandemic Mechanical thrombectomy for acute ischemic stroke amid the COVID-19 outbreak: decreased activity, and increased care delays Acute stroke care is at risk in the Era of COVID-19: experience at a Comprehensive Stroke Center in Barcelona Impact of the COVID-19 outbreak on acute stroke pathways-insights from the Alsace region in France Effect of COVID-19 on emergent stroke care: a regional experience Effect of lockdown on the management of ischemic stroke: an Italian experience from a COVID hospital Acute stroke in times of the COVID-19 pandemic: a multicenter Study Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy Randomised doubleblind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) Avoiding misdiagnosis in patients with posterior circulation ischemia: a narrative review Stroke care in Italy: an overview of strategies to manage acute stroke in COVID-19 time Conflicts of interest The authors declare that they have no conflict of interest. The effect of the COVID-19 pandemic on stroke care is still debated.


id: cord-260856-15k7pkh5
author: Buchanan, Sarah M.
date: 2020-06-24
extension: .txt
mime: text/plain
words: 2404
sentence: 98
flesch: 40
cache: cache/cord-260856-15k7pkh5.txt
txt: txt/cord-260856-15k7pkh5.txt
title:
  Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort

summary:
  The relationship between cerebral Alzheimer's disease pathology and odour identification in old age Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo Neuroimaging biomarkers and impaired olfaction in cognitively normal individuals Odor identification and Alzheimer disease biomarkers in clinically normal elderly Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly Olfactory identification in subjective cognitive decline and mild cognitive impairment: association with tau but not amyloid positron emission tomography Odor identification ability predicts PET amyloid status and memory decline in older adults Olfactory deficits and amyloid-β burden in Alzheimer's disease, mild cognitive impairment, and healthy aging: A PiB PET study Olfactory identification deficits and MCI in a multi-ethnic elderly community sample Relationships between lower olfaction and brain white matter lesions in elderly subjects with mild cognitive impairment Study protocol: Insight 46 -a Olfaction showed no association with β-amyloid status, hippocampal volume, entorhinal cortex thickness, AD signature cortical thickness, white matter hyperintensity volume, or cognition.


id: cord-267624-v6e9zzfg
author: Rinkel, L. A.
title: Impact of the COVID-19 outbreak on acute stroke care
date: 2020-07-20
extension: .txt
mime: text/plain
words: 2543
sentence: 94
flesch: 47
cache: cache/cord-267624-v6e9zzfg.txt
txt: txt/cord-267624-v6e9zzfg.txt
summary:
  However, since stroke patients in our region rarely are presented through outpatient clinics, the influence of suspension of outpatient services on acute stroke care is probably minimal. There was no change in the proportion of stroke patients treated with intravenous thrombolysis (28% vs. 30%, p = 0.58) or endovascular thrombectomy (11% vs 12%, p = 0.82) or associated treatment times.


id: cord-005014-qp4rrwr4
author: Martin, R.
date: 1988
extension: .txt
mime: text/plain
words: 2892
sentence: 122
flesch: 39
cache: cache/cord-005014-qp4rrwr4.txt
txt: txt/cord-005014-qp4rrwr4.txt
title:
  Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis

summary:
  It should also be mentioned that the direct comparison of the patterns of oligoclonal IgG bands with those specific for B. burgdorferi antigen may be difficult because the transfer conditions for total IgG and B. burgdorferi specific IgG are different, as already noted by D6rries and ter Meulen [6] . In a further step the antigen specificity of CSF IgG for the aetiological agent B. burgdorferi was shown by using the same blotting technique, but coupling B. burgdorferi antigen to the nitrocellulose filters.


id: cord-264647-9r443j3l
author: Talamonti, G.
title: Spinal epidural abscess in COVID-19 patients
date: 2020-09-10
extension: .txt
mime: text/plain
words: 2925
sentence: 163
flesch: 47
cache: cache/cord-264647-9r443j3l.txt
txt: txt/cord-264647-9r443j3l.txt
summary:
  key: cord-264647-9r443j3l authors: Talamonti, G.; Colistra, Davide; Crisà, Francesco; Cenzato, Marco; Giorgi, Pietro; D’Aliberti, Giuseppe title: Spinal epidural abscess in COVID-19 patients date: 2020-09-10 journal: J Neurol DOI: 10.1007/s00415-020-10211-z sha: doc_id: 264647 cord_uid: 9r443j3l OBJECTIVE: To report the peculiarity of spinal epidural abscess in COVID-19 patients, as we have observed an unusually high number of these patients following the outbreak of SARS-Corona Virus-2. To our knowledge, cases of spinal epidural abscess in COVID-19 patients have not been reported to date.


id: cord-338979-ew046wcr
author: Jasti, Madhu
title: A review of pathophysiology and neuropsychiatric manifestations of COVID-19
date: 2020-06-03
extension: .txt
mime: text/plain
words: 2979
sentence: 135
flesch: 39
cache: cache/cord-338979-ew046wcr.txt
txt: txt/cord-338979-ew046wcr.txt
summary:
  Presenting as acute ST elevation myocardial infarction Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China Smell dysfunction: a biomarker for COVID-19 Evidence of the COVID-19 virus targeting the CNS: tissue distribution, hostvirus interaction, and proposed neurotropic mechanisms High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients National Health Commission of the People′s Republic of China. Losses of smell and taste have been strongly linked to COVID-19 infections [12] .


id: cord-335593-cjb0daps
author: Romagnolo, Alberto
title: Neurological comorbidity and severity of COVID-19
date: 2020-08-04
extension: .txt
mime: text/plain
words: 3436
sentence: 146
flesch: 33
cache: cache/cord-335593-cjb0daps.txt
txt: txt/cord-335593-cjb0daps.txt
summary:
  A scoping review on the occurrence of neurological diseases in COVID-19 patients reported a prevalence of about 8% [12] . Nevertheless, this review highlighted the methodological heterogeneity in the reviewed papers, which limit a reliable estimation of prevalence of neurological diseases in COVID-19 patients, as well as their association with the infection severity.


id: cord-320149-3q4q98a6
author: Di Carlo, Davide Tiziano
date: 2020-08-01
extension: .txt
mime: text/plain
words: 3485
sentence: 151
flesch: 33
cache: cache/cord-320149-3q4q98a6.txt
txt: txt/cord-320149-3q4q98a6.txt
title:
  Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature

summary:
  An official clinical practice guideline of the The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses COVID-19 in a designated infectious diseases hospital outside Hubei Province COVID-19 with different severity: a multi-center study of clinical features Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study Olfactory and gustatory dysfunctions as a clinical presentation of mildto-moderate forms of the coronavirus disease (COVID-19): a multicenter European study The clinical and chest CT features associated with severe and critical COVID-19 pneumonia Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan Characteristics of COVID-19 infection in Beijing Clinical features and treatment of COVID-19 patients in northeast Chongqing Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Characteristics of emergency department patients with COVID-19 at a single site in Northern California: clinical observations and public health implications Clinical characteristics and outcomes of COVID-19 patients with a history of stroke in Wuhan China COVID-19 related neuroimaging findings: a signal of thromboembolic complications and a strong prognostic marker of poor patient outcome Imaging in neurological disease of hospitalized COVID-19 patients: an Italian multicenter retrospective observational study Brain imaging use and findings in COVID-19: a single academic center experience in the epicenter of disease in the United States Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study Human Coronaviruses: respiratory pathogens revisited as infectious neuroinvasive, neurotropic, and neurovirulent agents Middle East respiratory syndrome Nervous system involvement after infection with COVID-19 and other coronaviruses The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 Minireview: overview of the renin-angiotensin system-an endocrine and paracrine system Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Multiple organ infection and the pathogenesis of SARS Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 First case of 2019 novel coronavirus disease with encephalitis The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients Respiratory failure alone does not suggest central nervous system invasion by SARS-CoV-2 Reninangiotensin system: an old player with novel functions in skeletal muscle A first case of meningitis/encephalitis associated with SARS-Coronavirus-2 COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Characteristics of ischaemic stroke associated with COVID-19 COVID-19 presenting as stroke Stroke epidemiology: advancing our understanding of disease mechanism and therapy Hospitalization for infection and risk of acute ischemic stroke: the Cardiovascular Health Study Guillain-Barré syndrome associated with SARS-CoV-2 Early Guillain-Barré syndrome in coronavirus disease 2019 (COVID-19): a case report from an Italian COVID-hospital Miller Fisher syndrome and polyneuritis cranialis in COVID-19 Guillain Barre syndrome associated with COVID-19 infection: a case report Acute symptomatic seizures in critically Ill patients with COVID-19: is there an association? Data were obtained for the whole population and subsequently we divided it into two groups: severe patients and non-severe patients, according to the American Thoracic Society guidelines for community-acquired pneumonia


id: cord-012560-p5s0p7fd
author: Decavèle, Maxens
title: One-year survival of patients with high-grade glioma discharged alive from the intensive care unit
date: 2020-08-29
extension: .txt
mime: text/plain
words: 3720
sentence: 150
flesch: 39
cache: cache/cord-012560-p5s0p7fd.txt
txt: txt/cord-012560-p5s0p7fd.txt
summary:
  Because the prognosis of cancer patients is similar to that of non-cancer patients [1, 3] , a diagnosis of cancer should not preclude ICU admission. Incidence, life expectancy and prognostic factors in cancer patients under prolonged mechanical ventilation: a nationwide analysis of 5138 cases during The impact of critical illness on perceived health-related quality of life during ICU treatment, ICU stay, and after ICU discharge Long-term survival, quality of life, and quality-adjusted survival in critically ill patients with cancer Quality of life after intensive care: a systemic review of the literature Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study Review on quality of life issues in patients with primary brain tumors Health-related quality of life in patients with high grade gliomas: a quantitative longitudinal study Glioblastoma and other malignant gliomas: a clinical review The 2016 world health organization classification of tumors of the central nervous system: a summary A new method of classifying prognostic comorbidity in longitudinal studies: development and validation New simplified acute physiology score (SAPS II] based on a European/North American multicenter study The SOFA (Sepsis-related Organ Failure Assessment] score to describe organ dysfunction/failure.


id: cord-011302-pfepyvaw
author: Edlmann, Ellie
title: The changing face of neurosurgery for the older person
date: 2020-04-25
extension: .txt
mime: text/plain
words: 3897
sentence: 141
flesch: 37
cache: cache/cord-011302-pfepyvaw.txt
txt: txt/cord-011302-pfepyvaw.txt
summary:
  The barrow ruptured aneurysm Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial Dexamethasone therapy versus surgery for chronic subdural haematoma (DECSA trial): study protocol for a randomised controlled trial International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial National Institute for Health and Clinical Excellence (NICE) (2014) Head injury: assessment and early management clinical guidelines [CG176 Subarachnoid haemorrhage in patients %3e or = 75 years: clinical course, treatment and outcome The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review A global clinical measure of fitness and frailty in elderly people International subarachnoid aneurysm trial of neurosurgical clipping versus endovascular coiling Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial Minimally invasive surgery for intracerebral hemorrhage Aneurysmal subarachnoid hemorrhage in elderly patients: long-term outcome and prognostic factors in an interdisciplinary treatment approach Importance of frailty evaluation in the prediction of the prognosis of patients with chronic subdural hematoma Oertel Matthias F (2012) Intracerebral hemorrhage in the Very Old Endovascular treatment of intracranial aneurysms in elderly patients Efficacy and safety of minimal invasive surgery treatment in hypertensive intracerebral hemorrhage: a systematic review and meta-analysis The MRC CRASH trial collaborators (2020) However, poor outcomes still prevail in older patients with emergency presentations: Whitehouse reported 5-year mortality of around 55% in neurosurgical patients over 65 admitted as an emergency compared with less than 20% in elective patients [42] .


id: cord-279511-s9h1jzzs
author: Di Stefano, Vincenzo
date: 2020-07-13
extension: .txt
mime: text/plain
words: 4163
sentence: 168
flesch: 43
cache: cache/cord-279511-s9h1jzzs.txt
txt: txt/cord-279511-s9h1jzzs.txt
title:
  Significant reduction of physical activity in patients with neuromuscular disease during COVID-19 pandemic: the long-term consequences of quarantine

summary:
  Finally, we found a correlation between SF-12 scores and the entity of the reduction of PA level during quarantine, thus confirming a relevant association with the quality of life in NMD. In the present cross-sectional study we aimed to explore the impact of COVID-19 lockdown on PA in NMD and to quantify the expected reduction of PA levels, as well its effect on the quality of life.


id: cord-025749-mip9mkef
author: Jo, Sungyang
title: Newly developed stroke in patients admitted to non-neurological intensive care units
date: 2020-06-02
extension: .txt
mime: text/plain
words: 4137
sentence: 165
flesch: 41
cache: cache/cord-025749-mip9mkef.txt
txt: txt/cord-025749-mip9mkef.txt
summary:
  We defined stroke according to the findings on CT and/or MRI images of the brain, but only 22% of ICU patients underwent such neuroimaging studies, so patients who developed stroke but did not undergo neuroimaging studies, due to very unstable vital signs and early death soon after admission to the ICU, may not have been identified as having IOS. Patients with altered mental status as an initial stroke manifestation had time delays to the stroke recognition than patients without altered mental status (p = 0.027), while patients with seizure as an initial stroke manifestation had shorter time intervals for the stroke recognition than patients without seizure (p = 0.047).


id: cord-320755-0zpnwl2k
author: Mateen, Farrah J.
date: 2020-07-07
extension: .txt
mime: text/plain
words: 4240
sentence: 172
flesch: 47
cache: cache/cord-320755-0zpnwl2k.txt
txt: txt/cord-320755-0zpnwl2k.txt
title:
  Impact of COVID-19 on U.S. and Canadian neurologists’ therapeutic approach to multiple sclerosis: a survey of knowledge, attitudes, and practices

summary:
  Larger efforts are ongoing, but a synthesized report on MS patients and their outcomes was not yet published when our study commenced. The overall objectives of this study were threefold: (1) to report the range of impacts of COVID-19 on neuroimmunologists' practice across the USA and Canada; (2) to probe the MS DMT prescribing decisions and planning of neuroimmunologists in the setting of a viral pandemic; and (3) determine the unmet needs and sources of uncertainty that dominate the care of MS patients.


id: cord-345200-rxv9batt
author: Gigli, Gian Luigi
title: Guillain-Barré syndrome in the COVID-19 era: just an occasional cluster?
date: 2020-05-19
extension: .txt
mime: text/plain
words: 560
sentence: 17
flesch: 41
cache: cache/cord-345200-rxv9batt.txt
txt: txt/cord-345200-rxv9batt.txt
summary:
  Cellex qSARS-CoV-2 IgG/IgM Rapid Test Guillain-Barré syndrome associated with Zika virus infection in Colombia PCR polymerase chain reaction, CSF cerebrospinal fluid, NA not available, CMV Cytomegalovirus, EBV Epstein-Barr virus, HSV-1 Herpes simplex virus 1, HSV-2 Herpes simplex virus 2, HHV-6 Human herpes virus 6, HPeV Human parechovirus, VZV Varicella-zoster virus, TBE Tick-borne encephalitis, WNV West-Nile virus a We intend symptoms such as fever In fact, it is well known that GBS and related syndromes are often post-infectious (as for the influenza epidemics and more recently for Zika virus [5] ), with an usual latency of 10-14 days after infection [2] .


id: cord-301162-ux40twpt
author: Chiaravalloti, Nancy D.
title: The emotional impact of the COVID-19 pandemic on individuals with progressive multiple sclerosis
date: 2020-08-19
extension: .txt
mime: text/plain
words: 4800
sentence: 201
flesch: 39
cache: cache/cord-301162-ux40twpt.txt
txt: txt/cord-301162-ux40twpt.txt
summary:
  Only 57% of respondents reported any interaction with their medical team during lockdown orders, with a comparable proportion reporting MS symptom changes during the same time period (58%). No significant differences were noted on the BDI-II from baseline to lockdown; however, a significant difference was noted on the HADS-Depression scale from baseline to lockdown (p = 0.033), with a small increase in depression symptoms noted at the lockdown follow-up (Table 3 ).


id: cord-346530-o65m0whe
author: Chaumont, H.
title: Mixed central and peripheral nervous system disorders in severe SARS-CoV-2 infection
date: 2020-06-12
extension: .txt
mime: text/plain
words: 774
sentence: 34
flesch: 29
cache: cache/cord-346530-o65m0whe.txt
txt: txt/cord-346530-o65m0whe.txt
summary:
  Patients had comorbidities and were admitted for acute respiratory distress syndrome due to a proven SARS-CoV-2 infection. To note, before admission to intensive care unit, patients had no neurological symptom, except for anosmia or ageusia in two of them.


id: cord-345437-j3akzx10
author: Perry, Richard
title: What has caused the fall in stroke admissions during the COVID-19 pandemic?
date: 2020-06-29
extension: .txt
mime: text/plain
words: 694
sentence: 26
flesch: 57
cache: cache/cord-345437-j3akzx10.txt
txt: txt/cord-345437-j3akzx10.txt
summary:
  Either the incidence of stroke has declined during this period, or a higher proportion of patients who have strokes are never reaching stroke services We reasoned that any change in the spectrum of stroke severity in patients presenting during the pandemic might yield important clues to distinguish between these two possibilities, as follows.


id: cord-298894-t5hyfum3
author: Rifino, Nicola
date: 2020-10-07
extension: .txt
mime: text/plain
words: 4694
sentence: 207
flesch: 41
cache: cache/cord-298894-t5hyfum3.txt
txt: txt/cord-298894-t5hyfum3.txt
title:
  Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy

summary:
  Although soon after all Italian regions reported patients with COVID-19, the highest number of cases was in Eastern Lombardy [2] , specifically in the Bergamo's province with 11,313 confirmed COVID-19 patients up to April 30th 2020 Patients with peripheral nervous system involvement had more frequently severe ARDS compared to patients with cerebrovascular disease (87.1% vs 42%; difference = 45.1% 95% CI 42.0–48.2; χ(2)= 14.306; p < 0.0002) and with altered mental status (87.1% vs 55.6%; difference = 31.5% 95% CI 27.5–37.5%; χ(2)= 7.055; p < 0.01).


id: cord-355841-m6dl8a0w
author: Munz, Maike
title: Acute transverse myelitis after COVID-19 pneumonia
date: 2020-05-26
extension: .txt
mime: text/plain
words: 863
sentence: 51
flesch: 43
cache: cache/cord-355841-m6dl8a0w.txt
txt: txt/cord-355841-m6dl8a0w.txt
summary:
  Cases of Guillain-Barré Syndrome in association with severe COVID-19 infections were reported [6] . Previously, others suggested a direct infection of the central nervous system by human coronaviruses like SARS or MERS [4] .


id: cord-319805-b6ypt5d0
author: Siepmann, Timo
title: Association of history of cerebrovascular disease with severity of COVID-19
date: 2020-08-06
extension: .txt
mime: text/plain
words: 5102
sentence: 197
flesch: 36
cache: cache/cord-319805-b6ypt5d0.txt
txt: txt/cord-319805-b6ypt5d0.txt
summary:
  Investigation of early cohorts of COVID-19 patients in China focused on the effects of classic cardiovascular risk factors such as arterial hypertension and coronary heart disease or comorbidity in general [6, 7] . To approach this question, we assessed individual multicenter data from three cohorts of COVID-19 patients treated during the first months of the pandemic in Germany.


id: cord-352703-2g7mqnte
author: Glasmacher, Stella A.
date: 2020-09-05
extension: .txt
mime: text/plain
words: 893
sentence: 39
flesch: 48
cache: cache/cord-352703-2g7mqnte.txt
txt: txt/cord-352703-2g7mqnte.txt
title:
  The immediate impact of the COVID-19 pandemic on motor neuron disease services and mortality in Scotland

summary:
  key: cord-352703-2g7mqnte authors: Glasmacher, Stella A.; Larraz, Juan; Mehta, Arpan R.; Kearns, Patrick K. A.; Wong, Michael; Newton, Judith; Davenport, Richard; Gorrie, George; Morrison, Ian; Carod Artal, Javier; Chandran, Siddharthan; Pal, Suvankar title: The immediate impact of the COVID-19 pandemic on motor neuron disease services and mortality in Scotland date: 2020-09-05 journal: J Neurol DOI: 10.1007/s00415-020-10207-9 sha: doc_id: 352703 cord_uid: 2g7mqnte nan As of August 2020, more than 800,000 deaths worldwide have been attributed to COVID-19, of which > 41,000 have been in the United Kingdom and 2494 in Scotland [1] . Mortality was higher above 70 years age (1.48 95% CI 1.10, 1.99; P = 0.009) and lower below 50 years age (0.41 95% CIs 0.19, 0.80; P = 0.017, Fig. 1a ).


id: cord-340984-blkhfhe2
author: Gklinos, Panagiotis
title: Neurological manifestations of COVID-19: a review of what we know so far
date: 2020-05-26
extension: .txt
mime: text/plain
words: 2677
sentence: 115
flesch: 41
cache: cache/cord-340984-blkhfhe2.txt
txt: txt/cord-340984-blkhfhe2.txt
summary:
  The above-mentioned clinical case series in Wuhan, China, showed that 36.4% of COVID-19 patients had neurological symptoms at onset. Continuing documentation of neurological symptoms and signs, timely CSF testing, EEG, and brain autopsies of COVID-19 patients who did not survive may help us understand better the neurological manifestations of the novel coronavirus as well as the pathophysiological mechanisms of CNS involvement.


id: cord-285574-i0dh1u5i
author: Ferini-Strambi, Luigi
date: 2020-07-21
extension: .txt
mime: text/plain
words: 6804
sentence: 261
flesch: 33
cache: cache/cord-285574-i0dh1u5i.txt
txt: txt/cord-285574-i0dh1u5i.txt
title:
  COVID-19 and neurological disorders: are neurodegenerative or neuroimmunological diseases more vulnerable?

summary:
  The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system Angiotensin type 2 receptors: role in aging and neuroinflammation in the substantia nigra Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease Outcome of Parkinson's disease patients affected by COVID-19 Staging of brain pathology related to sporadic Parkinson's disease Movement disorders in the world of COVID-19 Management of advanced therapies in Parkinson's disease patients in times of humanitarian crisis: the COVID-19 experience Impact of the COVID-19 pandemic on Parkinson's disease and movement disorders Influence of Parkinsonism on outcomes of elderly pneumonia patients Effects of COVID-19 on Parkinson's disease clinical features: a community-based case-control study Incidence of anxiety in parkinson's disease during the coronavirus disease (COVID-19) pandemic The impact of the COVID-19 pandemic on Parkinson's disease: hidden sorrows and emerging opportunities Effect of high-intensity treadmill exercise on motor symptoms in patients with de novo Parkinson disease Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson's disease: adouble-blind, randomised controlled trial Mental health, physical activity, and quality of life in Parkinson's disease during COVID-19 pandemic Parkinson's disease and COVID-19: perceptions and implications in patients and caregivers Increased dependence of action selection on recent motor history in Parkinson's disease Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective Movement disorder societyunified Parkinson's disease rating scale use in the covid-19 Era E-Rehabilitation: One Solution for Patients With Parkinson's Disease in COVID-19 Era Implementation of telemedicine for urgent and ongoing healthcare for patients With Parkinson's disease during the COVID-19 pandemic: new expectations for the future Is the brain a reservoir organ for SARS2-CoV2? Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress The possible protective role of α-synuclein against the SARS-CoV-2 infections in patients with Parkinson's disease Lack of alpha-synuclein modulates microglial phenotype in vitro Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus Conductance and amantadine binding of a pore formed by a lysineflanked transmembrane domain of SARS coronavirus envelope protein The G8 dementia research summita starter for eight? Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients Risk factors for predicting mortality in elderly patients with COVID-19: a review of clinical data in China Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up Clinical characteristics and prognostic factors in COVID-19 patients aged ≥80 years Clinical presentation of COVID19 in dementia patients Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the cache county study The effects of confinement on neuropsychiatric symptoms in Alzheimer's disease during the COVID-19 crisis Neuropsychiatric signs and symptoms of Alzheimer's disease: new treatment paradigms Neuropsychiatric symptoms and quality of life in spanish patients with Alzheimer's disease during the COVID-19 lockdown Atypical presentation of covid-19 in an older adult with severe Alzheimer disease Delirium in hospitalized older adults Telemedicine in neurology: telemedicine work Group of the American Academy of neurology update Dementia care and COVID-19 pandemic: a necessary digital revolution Disability through COVID-19 pandemic: neurorehabilitation cannot wait Potential novel role of COVID-19 in Alzheimer's disease and preventative mitigation strategies A claims databased comparison of comorbidity in individuals with and without dementia Barrientos RMThe impact of nutrition on COVID-19 susceptibility and long-term consequences Anticipating and mitigating the impact of the COVID-19 pandemic on alzheimer's disease and related dementias Multiple sclerosis and the risk of infection: considerations in the threat of the novel coronavirus, COVID-19/SARS-CoV-2 Infections in patients diagnosed with multiple sclerosis: A multi-database study Infection risks among patients with multiple sclerosis treated with fingolimod, natalizumab, rituximab, and injectable therapies Disease-modifying drugs for multiple sclerosis and infection risk: a cohort study Risk of COVID-19 infection in MS and neuromyelitis optica spectrum disorders COVID-19 pandemic and the risk of infection in multiple sclerosis patients on disease modifying therapies: what the bleep do we know? Taken together, these finding suggest dementia, especially in the advanced stages of the disease, might represent an important risk factor for mortality in COVID-19 patients (Fig. 1) .


id: cord-351896-j6h02ab5
author: Ghannam, Malik
title: Neurological involvement of coronavirus disease 2019: a systematic review
date: 2020-06-19
extension: .txt
mime: text/plain
words: 5067
sentence: 178
flesch: 30
cache: cache/cord-351896-j6h02ab5.txt
txt: txt/cord-351896-j6h02ab5.txt
summary:
  Cytokine and anticytokine interventions Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity Guillain-Barré Syndrome Is COVID-19 a proteiform disease inducing also molecular mimicry phenomena? Steroid-responsive encephalitis in Covid-19 disease Immune thrombocytopenic purpura in a patient with Covid-19 Autoimmune haemolytic anaemia associated with COVID-19 infection The genetic sequence, origin, and diagnosis of SARS-CoV-2 Multiple organ infection and the pathogenesis of SARS Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease Dysregulation of immune response in patients with COVID-19 in Wuhan, China The COVID-19 pandemic: consideration for brain infection Isolated sudden onset anosmia in COVID-19 infection. D-dimers might play a major prothrombotic role in COVID-19 patients.


