1 J Bagh College Dentistry Vol. 33(1), March 2021 Efficacy of arthrocentesis Efficacy of arthrocentesis with injection of hyaluronic acid in the treatment of inflammatory-degenerative disease of temporomandibular joint Enas Abdulsattar Abdulmaged (1), Thair Abdul Lateef (2) https://doi.org/10.26477/jbcd.v33i1.2920 ABSTRACT Background:Temporomandibular joint (TMJ) problems refer to a group of heterogeneous pain and dysfunction conditions involving the mastication, reducing life quality of the patients. Arthrocentesis is a simple and less invasive surgical method for the treatment of inflammatory-degenerative disease than other conservative procedures and better than arthroscope. This clinical study aimed at evaluating the benefit of arthrocentesis with injection of hyaluronic acid in the management of inflammatory-degenerative disease of the TMJ. Material and methods: Eighty consecutive patients were enrolled in this study with pain symptoms of TMJ, insufficient masticatory efficiency during function and limitation of mouth opening; they were assessed with clinical examination and approved with computed tomography scan. Arthrocentesis was done by inserting 18 gauge needles in the upper joint compartment, lavage by normal saline solution and at the end of the procedure 1ml of hyaluronic acid (HA) was injected. Intensity of the TMJ pain and masticatory efficiency was analyzed by visual analog scale (VAS), maximum mouth opening (MMO) was assessed by a ruler. All the assessed parameters were measured before the procedure then 1 and 4 months later. Results: During 5 months follow-up, comparison of the obtained results showed reduction in pain at chewing and rest 87.5%, improvement in mouth opening 100% and significant improvement in masticatory efficiency 87.5% of patients. Conclusion: The procedure of arthrocentesis with Sodium Hyaluronate injection, used in patients who suffered from inflammatory- degenerative disease (IDD), showed therapeutic benefits, simplicity, safety, patient satisfaction, lack of significant side effects and complications. Key words: Arthrocentesis, inflammatory-degenerative disease, hyaluronic acid. (Received: 2/1/2018, Accepted: 11/2/2018) INTRODUCTION Temporomandibular joint disorders is an umberella term covering pain and dysfunction of TMJ and represents therapeutic challenge in our maxillofacial department.(1) Generally, the manegment of TMJ dysfunction depends on the criteria of TMJ condition and is based on the position and shape of the TMJ disc which is described by Dworkin and LeResche. The debate among scientists continues surrounding accompanying factor in tmj.(2) All these disorders make several of suffering represented by jaw pain, mastication efficiency, limited jaw movement and TMJ destruction.(3) Traditional non invasive approaches were applied to manegment of TMJ OA, physical therapy, occlusal splints acupuncture, pharmacological, injection of steroids and recently the injection of hyaluronic acid (HA) injection. (1) Senior of Oral and Maxillofacial Surgery in Al-Wasity Teaching Hospital. Baghdad –Iraq, Ministry of Health. (2) Assistant Professor in Oral and Maxillofacial Surgery Department, Collage of Dentistry, University of Baghdad. Corresponding email, drenas999@yahoo.com TMJ arthrocentesis is a minimally invasive technique, less expensive and simple with low morbidity used for flushing out TMJ that is done by double access to upper joint space.(4) Its application enhances jaw function and achieves pain relief in patients with restricted mouth opening.(5,6). HA infiltration which is polysaccharide of the family of glycosaminoglycans becomes an attributed option for the management and reliefing symptoms in the clinical setting.(7) This leads to the progressive expansion of potential clinical indications for the use of combined technique arthrocentesis which provides expansion of joint space and washing out intra articular inflammatory mediator and carbolytes coupled by Hyaluronic acid (HA) injection to enhance joint lubrication reducing joint friction and replacemrnt of synovial fluid in TMJ.(8) Namely, the effectiveness of joint lavage may be manifested by releasing the articular disc and breaking the adhesion and the adherence between disc surface and mandibular fossa thus increasing mouth opening.New era of utilization of Hyaluronic acid in TMJ disorders evolved. Aim: This purpose of current study was to evaluate the outcomings of arthrocentesis combined with https://doi.org/10.26477/jbcd.v33i1.2920 mailto:drenas999@yahoo.com 2 J Bagh College Dentistry Vol. 33(1), March 2021 Efficacy of arthrocentesis injection of hyaluronic acid in the treatment of inflammatory degenerative disease of temporomandibular joint. MATERIALS AND METHODS Eighty patients were included in this study (30 males and 50 females), age ranged from 18-55 years. Those patients were examined and treated in the clinic of oral and maxillofacial surgery in Al-Wasity Teaching Hospital. Baghdad –Iraq, Ministry of Health. (from November 2015 to October 2017). The inclusion criteria include: 1. The clinical signs. A. pain at rest and chewing. B. Mastication efficiency. C. maximum mouth opening (MMO). 2. Previous known conservative management failed to resolve symptoms. The exclusion criteria: A. patient received chemo or radiotherapy. B. patient with rheumatoid arthritis. Procedure The patients seated in supine position with skin of preauricular area were prepared. A refrance line (Holmlund-Hellsing line) was marked, eighteen gauge needles were inserted at 45 degree angle to corresponding plane during injection until reaching point space by feeling drop in the resistance to inserted needle. At least 120 ml of 9% normal saline solution should be used to wash the joint out for optimum result during lavage. An ampoule of HA was connected to the needle in situ and 1 ml of HA (Hyalgan, Fida, Albano, Italy) was injected into space. soft diet regimin was recommended for the patient . NSAID (Olfen* 100 mg, acino, Swiss) once daily was prescribed for 3 days with prophylactic antibiotic Augmentin 625 mg three times daily ,see figure1. Follow up period Predetermined variables were assessed to test the efficacy of the treatment protocol. 4 months was the period between the 1st follow-up visit (at 1 month from 1st injection procedure) and 2nd follow up visit, all the parameters for TMJ functions measured with the same technique. The criteria for success was no pain VAS equal to zero, mastication efficiency was eating solid hard food. *The evaluation between different follow up results was done by using mcnemar Chi square test and (F- test) and the results were considered significant if P < 0.05. *The pain and Mastication efficiency data assessed by VAS from 0 to10. * MMO data assessed by normal mouth opening range from 35-45mm RESULTS Eighty patients were included in this study, there were 50 females (62.5% and 30 males 37.5%), with a mean age 31.5 years. Description and Statistics of Data 1. Masticatory Efficiency The data obtained from visual analog value scale show significant reduction in masticatory efficiency from (6.75 to 2.25) at 5month follow up with (p value < 0.01) with success rate (87.5%). Pre-treatment and post-treatment data are shown in table (1). Table 1 : Masticatory efficiency (before and after treatment). ANOVA Post-treatment Pre-treatment Masticatory Efficiency P-value 2nd follow-up visit (4 month) 1st follow-up visit (1 month) No. (%) No. (%) No. (%) P < 0.01 HS * Total 40 (100%) Improved 30 (75%) Total 80 (100%) Improved 40 (50%) 80(100%) Mean 2.25 Mean 4.45 Mean 6.75 SD 0.056 SD 0.111 SD 0.168 *Highly significant improvement in masticatory efficiency (p value < 0.01). 2. Pain level The data optained from VAS revealed significant reduction in pain at 5 months follow up. A. Maximum pain at chewing In all patients maximum pain at chewing present and decrease in tendency. The pre- treatment and post-treatment data are shown in table (2). 3 J Bagh College Dentistry Vol. 33(1), March 2021 Efficacy of arthrocentesis Table 2: Maximum pain at chewing (before and after treatment). ANOVA Post-treatment Pre-treatment Maximum pain at chewing P-value 2nd follow-up visit (4 month) 1st follow-up visit (1 month) No. (%) No. (%) No. (%) P<0.01 HS * Total 40 (100%) Improved 30 (75%) Total 80 (100%) Improved 40 (50%) 80(100%) Mean 2.35 Mean 3.53 Mean 6.68 SD 0.058 SD 0.088 SD 0.167 *Highly significant improvement in maximum pain at chewing ( p value <0.01 ). B. Maximum pain at rest In all patients maximum pain at resting present and decrease in tendency. The data of pre-treatment and post-treatment are shown in table (3). Table 3: Maximum pain at rest (before and after treatment). ANOVA Post-treatment Pre-treatment Maximum pain at rest P-value 2nd follow-up visit (4 month) 1st follow-up visit (1 month) No. (%) No. (%) No. (%) P<0.01 HS * Total 40 (100%) Improved 30 (75%) Total 80 (100%) Improved 40 (50%) 80(100%) Mean 1.99 Mean 3.32 Mean 5.50 SD 0.049 SD 0.083 SD 0.137 *Highly significant improvement in maximum pain at rest ( p value <0.01 ). 3. Maximal mouth opening Initial measurement of maximum mouth opening detected 50 patients included in this study with a limited mouth opening. This study demonstrated success rate (100%) with ( P value < 0.01 ). As shown in table (4) Table 4: Maximum mouth opening (before and after) P-value follow up visit nd2 (3 month) follow up visit st1 (1 month) Pre-treatment 0.003 P<0.01 HS* 50 50 50 No. mouth opening evaluation 40mm 36mm 32.5mm Mean *Highly significant improvement in MMO ( p < 0.01 value ). DISCUSSION The effectiveness of arthrocentesis procedure with HA injection in this study was based on 3 clinical parameters: Masticatory Efficiency, pain reduction during function and increase in MMO. Many clinicians and researchers have reported uniformly positive results of patients treated with arthrocentesis. All patients in the study were suffering from limited Masticatory Efficiency and their score equal to 6.75 rang from 5 to 8. There is reduction in the mean of Masticatory Efficiency score to 4.45 ranged from 3 to 6 for all patients at 1st follow-up visit. Forty patients 50% showed complete response following single injection only, while remaining 40 patients 50% need 2nd injection. The data illustrated highly significant reduction in Masticatory Efficiency from 6.75 to 2.25 with a p< 0.01 and a success rate of 87.5%. These results agree with studies by D. Manfredini et al 8. All patients in the study were complaining from TMJ pain, with a score of pain at mastication equal to 6.68 ranging from 5 to 8 and showed significant reduction in pain to 2.35 with a p< 0.01 with a success rate 87.5%. These results agree with studies done by D. Manfredini et al (8). The data showed highly significant improvement in pain at rest from5.5 to1.99 with a p < 0.01 with a success rate 87.5%. These results agree with studies done by D. Manfredini et al(8). The Study data showed significant improvement in maximum mouth opening of patients P < 0.01, with success rate 100%. 4 J Bagh College Dentistry Vol. 33(1), March 2021 Efficacy of arthrocentesis These results agree with studies done by Nitzan DW(9) with the average mean for maximum mouth opening 32.5to 40 mm with a P < 0.01. CONCLUSION The procedure of arthrocentesis with Sodium Hyaluronate injection offers therapeutic benefits, simplicity, safety, patient satisfaction, lack of significant side effects and complications. REFERENCES 1. American Dental Association: Report of Presidents conference on the examination, diagnosis and management of temporomandibular disorders .J Am Dent Assoc 1988; 66:75. 2. Quinn JH, Bazan NG: Identification of prostaglandin E2 and leukotriene B4 in the synovial fluid of painful, dysfunction temporomandibular joint. J Oral Maxillofac Surg. 1990; 48:968. 3. Guarda-Nardini L, Stifano M, Brombin C et al. A one year series of arthrocentesis with hyaluronic acid injection for TMJ osteoarthritis. Oral surg Med Oral Pathol Oral Radiol Endod. 2007; 103:14-22. 4. Santos GS, Calado R, Sousa NE et al. Arthrocentesis Procedure:Using this therapeutic maneuver for TMJ closed lock Management: J Craniofac Surg. 2013; 24:1347-9. 5. Nitzan DW, Dolwick MF, Martinez GA. Temporomandibular Joint arthrocentesis; a simplified method for severe, limited mouth opening. J Oral Maxillofac Surg. 1991; 49:1163-1167. 6. Nitzan DW, Samson B, Better H. Long-term outcome of arthrocentesis for sudden-onset, persistent, severe closed lock of the Temporomandibular Joint. J Oral Maxillofac Surg. 1997; 55:151-157. 7. Peter A. Brennan Vellupillai Ilankovan, Arthrocentesis for TMJ pain Dysfunction syndrome. J Oral Maxillofac Surg. 2006; 64:949-951. 8. Manfredini D, Rancitelli D, Ferronato G, Guarda-nardini L. Arthrocentesis with or without additional drugs in Temporomandibular Joint inflammatory –degenerative disease: comparison of six protocol. J Oral Rehab. 2012; 39: 245–251. 9. Nitzan DW. Arthrocentesis for management of severe closed lock of the temporomandibular joint: current controversies in surgery for internal derangement of the temporomandibular joint. Atlas Oral Maxillofac Surg Clin North Am. 1994; 6: 245. Figure 1: The manuver of arthrocentesis accompined by Hyaluronic Acid injection. (A) The drawn line from mid tragus of the ear to the lateral canthus of eye (Holmlund-Hellsing line), (B)The two needles procedure, (C)Wash with normal saline with spurt of solution from the second needle during the lavage, (D)Injection of 1 ml of HA. A C B D 5 J Bagh College Dentistry Vol. 33(1), March 2021 Efficacy of arthrocentesis المستخلص م واالختالل الوظيفي للنظام المضغي ,وذلك لمجموعة من االعراض المتمثلة باالامراض واضطرابات المفصل الصدغي تمثل الخلفية: بسيطة واقل عرضه لعالج مرض القرص التنسكي للمفصل الصدغي. معاناة الحياة.عملية بزل المفصل هي بتقليل لتقيم تاثير عملية بزل المفصل باستخدام مادة حامض الهيلورونيك في عالج مرض القرص التنسكي للمفصل : تستهدف هذه الدراسة الهدف الصدغي الجميع ا ثمانون مريض :والطريقة المادة يعاني حيث الدراسة خالل هذه تنظيمهم التنسكي تم واضطرابات مرض القرص اعراض من في الجزء االعلى 18,حيث تم تقيمهم سريريا وكذلك باستعمال االشعه المقطعيه وذلك باستخدام نيدل عدد اثنين قياس للمفصل الصدغي الصدغي المفصل بمقدار من الهيلورونيك حامض ,وحقن مادة النورمل سالين الع سس1,باستخدام مادة نهاية باختزال وذل ملية في ك تتم متابعتهم بعد شهر وكذلك بعد اربعة اشهر . لم واالختالل الوظيفي للنظام المضغي , جميع الحاالت االعراض المتمثله باال بنسبة : النتائج االلم اختزال مالحظة مع النتائج مقارنة تتم المتابعه من اشهر خمسة بنسبة 87,5خالل الفم فتحة في تطور %وكذلك %. 87,5%,وفي النظام المضغي بنسبة 100 مرض القرص التنكسي للمفصل عملية بزل المفصل الصدغي باستعمال حامض الهيلورونيك تستعمل لمرضى اضطرابات : ات االستنتاج الصدغي بمالحظة استفادة جميع المرضى ,وسهولة العملية ,مع غياب اي اعراض جانبية خالل العملية . بزل المفصل ,مرض القرص التنسكي للمفصل الصدغي ,مادة حامض الهيلورونيك. عمليه: الكلمات الدالة Articles Published by Journal of Baghdad College of Dentistry is licensed under a Creative Commons Attribution 4.0 International License. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/