item: #1 of 80 id: jcb-2033 author: Atay, Safinur; Roberson, Carolyn D.; Gercel-Taylor, Cicek; Taylor, Douglas D. title: Ovarian Cancer-Derived Exosomal Fibronectin Induces Pro-Inflammatory IL-1β date: 2013-01-01 words: 6381 flesch: 43 summary: Using macrophage‐like THP‐1 cells, induction of IL‐1β  release was investigated by ELISA. RGD peptides were  used  to  block  fibronectin  binding  by  THP‐1  51  integrin.  Incubation  of  THP‐1  cells  with  these  exosomes  induced  pro‐inflammatory  cytokines,  in  particular  IL‐1β.  keywords: cancer; cells; cytokines; exosomes; fibronectin; human; il‐1; macrophages; oex; ovarian; production; protein; thp‐1; vesicles cache: jcb-2033.pdf plain text: jcb-2033.txt item: #2 of 80 id: jcb-2034 author: Gould, Stephen J.; Taylor, Douglas; Chiesi, Antonio; Kuo, Winston P. title: Announcing Exosomes and Microvesicles, the Official Journal of the American Society for Exosomes and Microvesicles date: 2013-01-01 words: 2865 flesch: 37 summary: Abstract  This  editorial  article  introduces  the  new  scientific  journal Exosomes and Microvesicles  (EXMV),  the  official journal of the American Society for Exosomes and  Microvesicles  (ASEMV),  and  describes  its  editorial  line  and mission in relation to the role of the Society, the state  of the art of the study of exosomes and microvesicles, and  the overall approach of the publication.    Exosomes and Microvesicles Editorial Announcing Exosomes and Microvesicles, the official journal of the American Society for Exosomes and Microvesicles Stephen J. Gould1, Douglas Taylor2, Antonio Chiesi3 and Winston P. Kuo4 1 Department of Biological Chemistry, the Johns Hopkins University, Baltimore, MD, USA 2 Department of Obstetrics, Gynecology & Women’s Health, University of Louisville School of Medicine, Louisville, KY, USA 3 Exosomics Siena SpA, Siena, Italy 4 Harvard Catalyst, Laboratory for Innovative Translational Technologies, Harvard Medical School, Boston, MA, USA; Department of Developmental Biology, Harvard School of Dental Medicine, Cambridge, MA, USA * keywords: cancer; cell; exosomes; field; journal; microvesicles; research; society; use cache: jcb-2034.pdf plain text: jcb-2034.txt item: #3 of 80 id: jcb-2035 author: Hendrix, An; Ciccone, Carla; Gespach, Christian; Bracke, Marc; De Wever, Olivier; Westbroek, Wendy title: Rab27B-Mediated Metabolic Reprogramming Induces Secretome Acidification and Chemoresistance in Breast Cancer Cells date: 2013-01-01 words: 3971 flesch: 42 summary: Cells  were seeded at a density of  15,000  in XF24 cell culture  microplates  (Seahorse  Bioscience)  in  a  culture  medium  and incubated at 37°C in 10% CO2 for 24 hours.  Cells were cultured  for 24 hours during  the  exponential growth after assay medium refreshment. keywords: acidification; breast; cancer; cells; gfp‐rab27b; glycolysis; mcf‐7; medium; phe; rab27b cache: jcb-2035.pdf plain text: jcb-2035.txt item: #4 of 80 id: jcb-2036 author: Suntres, Zacharias E.; Smith, Milton G.; Momen-Heravi, Fatemeh; Hu, Jie; Zhang, Xin; Wu, Ying; Zhu, Hongguang; Wang, Jiping; Zhou, Jian; Kuo, Winston Patrick title: Therapeutic Uses of Exosomes date: 2013-01-01 words: 6433 flesch: 49 summary: Tumor- derived exosomes were shown to directly suppress the activity of effector T cells or target myeloid cells to modu‐ late their differentiation and function such as in the case where exosomes derived from human melanoma cell lines and colorectal carcinoma cell lines were demonstrated to skew monocyte differentiation into DCs toward the generation of myeloid-derived suppressor cells (MDSCs) and exert TGF-β1 mediated suppressive activity on T cells in vitro Recognizing the fact that the exosomes have a size that range between 40 to 100 nm, with density ranging between 1.13 and 1.21 g/mL, and contain cell type specific proteins, isolation procedures have focused on techniques based on size and density and biochemical properties. keywords: 2010; 2012; antigen; cancer; cells; dcs; delivery; disease; exosomes; harvard; human; immune; membrane; mice; mol; proteins; res; responses; tumor; vaccine; vesicles; wang cache: jcb-2036.pdf plain text: jcb-2036.txt item: #5 of 80 id: jcb-2037 author: Camussi, Giovanni; Quesenberry, Peter J. title: Perspectives on the Potential Therapeutic Uses of Vesicles date: 2013-01-01 words: 7243 flesch: 50 summary: [41] Quesenberry PJ, Aliotta JM: The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles. Identification of the innate properties of extracellular vesicles derived from stem cells and from immune cells has led to the possibility of their exploitation in regenerative medicine and immune therapies. keywords: 2012; camussi; cells; delivery; exosomes; human; immune; injury; marrow; mesenchymal; microvesicles; mrna; msc; potential; protein; stem; stem cells; target; transfer; vesicles cache: jcb-2037.pdf plain text: jcb-2037.txt item: #6 of 80 id: jcb-2038 author: Yeo, Ronne Wee Yeh; Lai, Ruenn Chai; Tan, Kok Hian; Lim, Sai Kiang title: Exosome: A Novel and Safer Therapeutic Refinement of Mesenchymal Stem Cell date: 2013-01-01 words: 8978 flesch: 49 summary: Nat Med 15: 42-49 [31] Raffaghello L, Bianchi G, Bertolotto M, et al. (2008) Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche. Blood 99: 3838-3843 [26] Djouad F, Charbonnier L, Bouffi C, et al. (2007) Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-depend‐ ent mechanism. keywords: acute; atp; blood; bone; cells; cellular; diseases; efficacy; et al; exosomes; function; human; injury; ischemia; journal; membrane; mesenchymal; mesenchymal stem; msc; msc exosomes; mscs; protein; reperfusion; stem; stem cells; therapeutic; tumor; vesicles cache: jcb-2038.pdf plain text: jcb-2038.txt item: #7 of 80 id: jcb-2039 author: Roberson, Carolyn D.; Gercel-Taylor, Cicek; Qi, Ying; Schey, Kevin L.; Taylor, Douglas D. title: Identification of Immunoreactive Tumour Antigens Using Free and Exosome-Associated Humoral Responses date: 2013-01-01 words: 7628 flesch: 44 summary: 9Carolyn D. Roberson, Cicek Gercel-Taylor, Ying Qi, Kevin L. Schey and Douglas D. Taylor: Identification of Immunoreactive Tumour Antigens Using Free and Exosome-Associated Humoral Responses [16] Dolo V, D'Ascenzo S, Violini S, Pompucci L, Festuccia C, Ginestra A, Vittorelli ML, Canevari A, Pavan A (1999) Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer cells in vivo and in vitro. Using human ovarian cancer as our model system, we investigated immunoreactivity of tumour-associated antigen of ovarian patient cancer cells, patient in vivo and in vitro-derived tumour exosome antigens and patient- derived free and exosome-associated antibodies. keywords: alpha; annexin; antibodies; antigens; cancer; cathepsin; cells; enolase; exosomes; expression; gel; humoral; interest; mass; ovarian; patient; proteins; recognition; response; serum; taylor; tde; tumour; western cache: jcb-2039.pdf plain text: jcb-2039.txt item: #8 of 80 id: jcb-2040 author: Danielson, Kirsty M.; Das, Saumya title: Extracellular Vesicles in Heart Disease: Excitement for the Future? date: 2014-01-01 words: 7486 flesch: 47 summary: This suggests two possible strategies for using EVs as a therapeutic: deliberate packaging of specific components into vesicles for targeted delivery and use of endogenously- produced stem cell EVs without designed contents. 7. Conclusion In summary, EVs released from cardiovascular cells have been shown to transfer to different cell types and cause changes in RNA and protein expression that have significant downstream functional effects. keywords: biology; biomarkers; bodies; cardiac; cardiovascular; cells; cms; disease; endothelial; evs; exosomes; heart; human; journal; microvesicles; mirnas; release; role; stem; studies; transfer; types cache: jcb-2040.pdf plain text: jcb-2040.txt item: #9 of 80 id: jcb-2041 author: Hexley, Philip; Rismiller, Kyle P.; Robinson, Chad T.; Babcock, George F. title: Protocol Standardization Reveals MV Correlation to Healthy Donor BMI date: 2014-01-01 words: 5006 flesch: 57 summary: No significant differences between circulating plasma MV numbers between male and female samples were observed, nor was there any relationship between baseline MV number and the age of the donor (Table 1). Table showing donor age, sex, BMI, circulating plasma MV numbers and Hemavet 1700FS (Drew Scientific) cellular blood parameters. keywords: analysis; baseline; blood; bmi; cell; correlation; cytometry; donor; flow; microparticles; mvs; numbers; plasma; sample; scatter; standardization cache: jcb-2041.pdf plain text: jcb-2041.txt item: #10 of 80 id: jcb-2042 author: Ankarklev, Johan; Hjelmqvist, Daisy; Mantel, Pierre-Yves title: Uncovering the Role of Erythrocyte-Derived Extracellular Vesicles in Malaria: From Immune Regulation to Cell Communication date: 2014-01-01 words: 8931 flesch: 54 summary: Hamon et al. discovered that the shedding of RBC EVs is reduced by about 70% upon ionophores stimulation in the 4 J Circ Biomark, 2014, 3:3 | doi: 10.5772/58596 ABC1-/- mice [60]. Intriguingly, at a similar level as that seen by Mantel et al., where EVs from P falciparum iRBCs were shown to have an important role in parasite density regulation [69]. keywords: activation; cell; disease; dna; endothelial; et al; evs; exosomes; falciparum; host; human; infection; irbcs; malaria; microparticles; parasite; patients; plasmodium; platelet; regulation; role; stage; tnf; transfer; vesicles cache: jcb-2042.pdf plain text: jcb-2042.txt item: #11 of 80 id: jcb-2043 author: Vishnubhatla, Indira; Corteling, Randolph; Stevanato, Lara; Hicks, Caroline; Sinden, John title: The Development of Stem Cell-Derived Exosomes as a Cell-Free Regenerative Medicine date: 2014-01-01 words: 9693 flesch: 49 summary: [99] Lai RC, Yeo RW, Tan KH and Lim SK (2013) Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation. It has been well documented that stem cells have the ability to release a range of growth factors, cytokines and chemokines relevant to their function; however, these factors are released at levels too low to account for the reported therapeutic effects. keywords: biology; cell; et al; exosomal; exosomes; flow; human; journal; lipid; medicine; membrane; mesenchymal; microvesicles; mirna; molecules; msc; proteins; research; stem; stem cell; therapeutic; therapy; transfer; vesicles cache: jcb-2043.pdf plain text: jcb-2043.txt item: #12 of 80 id: jcb-2044 author: Jia, Shidong; Kuo, Winston Patrick title: New Year, New Name and New Milestones Scope — Journal of Circulating Biomarkers date: 2014-01-01 words: 814 flesch: 26 summary: Dr. Jia is an internationally recognized scientist in the extracellular vesicle field, among other circulating biomarkers and we look forward to working closely with him in bringing international exposure and success to the journal. Abstract This editorial article introduces a renaming of journal Exosomes and Microvesicles (EXMV) to the Journal of Circulating Biomarkers with a new editorial scope, mission and our approach for the upcoming year in relation to engaging at the international level, the translational art of the study of exosomes and microvesicles, and the interface between exosomes and microvesicles, circulating tumor cells, cell-free circulating DNA and circulating protein markers in precision medicine and drug development. keywords: exosomes; journal; microvesicles cache: jcb-2044.pdf plain text: jcb-2044.txt item: #13 of 80 id: jcb-2045 author: Fais, Stefano title: “I Have a Dream” date: 2014-01-01 words: 2820 flesch: 53 summary: The first one, by David Shaywitz and Nassim Taleb, was published in The Financial Times in 2008 (1), and discusses the reasons for this dramatic failure in drug discovery. In the authors’ own words: “The molecular revolution was supposed to enable drug discovery to evolve from chance observation into rational design, yet dwindling pipelines threaten the survival of the pharmaceutical industry. keywords: cancer; discovery; diseases; drug; fais; research; serendipity cache: jcb-2045.pdf plain text: jcb-2045.txt item: #14 of 80 id: jcb-2046 author: Campanella, Claudia; Bavisotto, Celeste Caruso; Gammazza, Antonella Marino; Nikolic, Dragana; Rappa, Francesca; David, Sabrina; Cappello, Francesco; Bucchieri, Fabio; Fais, Stefano title: Exosomal Heat Shock Proteins as New Players in Tumour Cell-to-Cell Communication date: 2014-01-01 words: 7526 flesch: 58 summary: Increasing evidence supports the notion that each cytotype produces EVs (including T cells, B cells, dendritic cells, platelets, epithelial cells and cancer cells), which are essential players in intercellular communication and that they establish the ability of a cell to sense and adapt to environmental alterations Extracellular Hsp70 exert immunomodulatory effects and play a key role in the immune response to cancer cells [85]. keywords: biol; cancer; cappello; cells; chaperones; communication; doi; exosomal; exosomes; functions; heat; hsp60; hsps; human; macario; mechanism; membrane; molecules; plasma; proteins; role; shock; tumour; vesicles cache: jcb-2046.pdf plain text: jcb-2046.txt item: #15 of 80 id: jcb-2047 author: Balaj, Leonora; Momen-Heravi, Fatemeh; Chen, Weilin; Sivaraman, Sarada; Zhang, Xuan; Ludwig, Nicole; Meese, Eckart; Wurdinger, Thomas; Noske, David; Charest, Alain; Hochberg, Fred H.; Vandertop, Peter; Skog, Johan; Kuo, Winston Patrick title: Detection of Human c-Myc and EGFR Amplifications in Circulating Extracellular Vesicles in Mouse Tumour Models date: 2014-01-01 words: 5145 flesch: 53 summary: Extracellular vesicles are nano-sized membrane bound particles released by essentially all cell types, including tumour cells, in vivo as well as in vitro, and comprise a mixed population of exosomes, shed microvesicles, and apoptotic blebs Tumour cells were injected subcutaneously into both flanks of immunocompromised mice and tumours allowed to grow for one month. keywords: a431; carcinoma; cell; d384; egfr; epidermoid; evs; human; levels; medulloblastoma; mrna; myc; tumour cache: jcb-2047.pdf plain text: jcb-2047.txt item: #16 of 80 id: jcb-2048 author: Anile, Marco; Chiappetta, Caterina; Diso, Daniele; Liparulo, Valeria; Leopizzi, Martina; Rocca, Carlo Della; Venuta, Federico title: Influence of Lung Parenchyma Surgical Manipulation on Circulating Free DNA date: 2014-01-01 words: 3172 flesch: 52 summary: Based on previous experimental studies on cfDNA plasma levels after surgical procedures, some authors focused on circulating cancer cells and nucleic acids, postulating in animal models that their postoperative increased levels might show an impact on the mechanism of metastatic spreading [14, 15]. Results: CfDNA levels measured preoperatively and in the control group were 23 07 ± 7 4 ng/mL and 7 5 ± 3 4 ng/mL respectively (p=0 0002); levels at one week and one month were 68 2 ± 36 2 ng/mL and 9 6 ± 3 1 ng/mL respectively. keywords: cancer; cfdna; levels; lung; month; patients; plasma; surgery cache: jcb-2048.pdf plain text: jcb-2048.txt item: #17 of 80 id: jcb-2049 author: Lötvall, Jan; Skog, Johan; Vlassov, Alexander V.; Sacido, Angel Ayuso; Rohde, Eva; Gere, Joanne; Kuo, Winston Patrick title: Short Course in Extracellular Vesicles — The Transition from Tissue to Liquid Biopsies date: 2014-01-01 words: 3547 flesch: 46 summary: Life Technologies (now part of Thermo Fisher Scientific) developed a complete exosome workflow solution: (i) the fast and efficient recovery of exosomes from serum, plasma, urine, cerebrospinal fluid, amniotic fluid, ascitic fluid, milk, saliva and cell media using total exosome isolation reagents; (ii) the extraction of their “cargo” with total exosome RNA and a protein isolation kit; (iii) the characterization of exosomal RNA content using the Ion Torrent Proton sequencing and qRT-PCR with TaqMan® assays. Johan mentioned that there are multiple sources of RNA in biofluids and that exosome RNA is not the same as the direct precipitation of RNA. keywords: cancer; cell; evs; exosomes; jan; johan; research; rna; session; vesicles cache: jcb-2049.pdf plain text: jcb-2049.txt item: #18 of 80 id: jcb-2051 author: Jia, Shidong; Kuo, Winston Patrick title: Year of Expanding into Circulating Biomarkers date: 2015-01-29 words: 1091 flesch: 22 summary: Keywords Extracellular vesicles, exosomes, microvesicles, circulating tumour cells, cell-free circulating DNA, edito‐ rial We are proud to announce that during the past year we have experienced several ongoing developments, one of which has been the expansion of our editorial board with key opinion leaders in the circulating biomarker field including Yvon E. Cayre (Pierre and Marie Curie Univer‐ sity, France), Alain Charest (Tufts University School of Medicine, USA), Yong Chen (Ecole Normale Superieure, France), Daniel Haber (Harvard Medical School, USA), Pavel Laktionov (Russian Academy of Sciences, Russian Federation) and David T. Wong (University of California Los Angeles, USA), all of whom contribute as part of our associate editor’s team. ARTICLE Journal of Circulating Biomarkers Year of Expanding into Circulating Biomarkers Editorial Shidong Jia1 and Winston Patrick Kuo2* 1 Genentech Inc., South San Francisco, USA 2 IES Diagnostics, Inc., Cambridge, USA *Corresponding author(s) E-mail: wkuo@iesdiagnostics.com DOI: keywords: biomarkers; cell; editorial; research; usa; vesicles cache: jcb-2051.pdf plain text: jcb-2051.txt item: #19 of 80 id: jcb-2052 author: Sadovska, Lilite; Santos, Cristina Bajo; Kalniņa, Zane; Linē, Aija title: Biodistribution, Uptake and Effects Caused by Cancer-Derived Extracellular Vesicles date: 2015-03-25 words: 11488 flesch: 58 summary: An increasing body of evidence suggests that cancer-derived EVs mediate paracrine signalling between cancer cells. In cancer, EVs have been shown to mediate paracrine signalling between cancer cells, cross- talk between tumour and microenvironment, contribute to the formation of the pre-metastatic niche and interfere with the anti-tumour immune response. keywords: biol; blood; breast; breast cancer; cancer; cancer cells; cancer evs; cells; effects; evs; exosomes; extracellular; growth; human; i.v; liver; lungs; lymph; melanoma; mice; microvesicles; nodes; promote; stem; studies; study; t cells; transfer; tumour; types; uptake; vesicles; vivo; wang cache: jcb-2052.pdf plain text: jcb-2052.txt item: #20 of 80 id: jcb-2053 author: Werner, Shannon L.; Graf, Ryon P.; Landers, Mark; Valenta, David T.; Schroeder, Matthew; Greene, Stephanie B.; Bales, Natalee; Dittamore, Ryan; Marrinucci, Dena title: Analytical Validation and Capabilities of the Epic CTC Platform: Enrichment-Free Circulating Tumour Cell Detection and Characterization date: 2015-05-05 words: 9851 flesch: 51 summary: Cytotherapy. 6: 244-52 [28] Yang L, Lang J C, Balasubramanian P, Jatana K R, Schuller D, Agrawal A, Zborowski M and Chalmers J J (2009) Optimization of an enrichment process for circulating tumor cells from the blood of head and neck cancer patients through depletion of normal cells. 178: 989-96 [69] Rhim A D, Mirek E T, Aiello N M, Maitra A, Bailey J M, McAllister F, Reichert M, Beatty G L, Rustgi A K, Vonderheide R H, Leach S D and Stanger B Z (2012) EMT and dissemination precede pancreatic tumor formation. keywords: analysis; assay; biomarker; blood; cancer; cells; clcs; ctc; ctcs; detection; donor; enumeration; epic; epithelial; expression; figure; operator; patient; platform; prostate; run; samples; slides; total; tumor; tumor cells cache: jcb-2053.pdf plain text: jcb-2053.txt item: #21 of 80 id: jcb-2054 author: Lu, David; Graf, Ryon P.; Harvey, Melissa; Madan, Ravi A.; Heery, Christopher; Marte, Jennifer; Beasley, Sharon; Tsang, Kwong Y.; Krupa, Rachel; Louw, Jessica; Wahl, Justin; Bales, Natalee; Landers, Mark; Marrinucci, Dena; Schlom, Jeffrey; Gulley, James L.; Dittamore, Ryan title: Detection and Characterization of Circulating Tumour Cells from Frozen Peripheral Blood Mononuclear Cells date: 2015-05-13 words: 5249 flesch: 50 summary: CTC samples from previously archived (frozen) clinical samples with associated long clinical histories Typical CTC recovery in frozen samples was significant‐ ly lower as median CTC recovery in frozen samples was 18% that observed from freshly processed blood. keywords: blood; cells; characterization; ctcs; epic; expression; fresh; frozen; patient; pbmc; protein; recovery; samples cache: jcb-2054.pdf plain text: jcb-2054.txt item: #22 of 80 id: jcb-2056 author: Huang, Tao; Banizs, Anna B.; Shi, Weibin; Klibanov, Alexander L.; He, Jiang title: Size Exclusion HPLC Detection of Small-Size Impurities as a Complementary Means for Quality Analysis of Extracellular Vesicles date: 2015-07-10 words: 4415 flesch: 55 summary: First, in our study, no detailed information on vesicle size is gained by Figure 2. As SE-HPLC is generally accessible in most institutions, it could be used as a routine means to assist researchers in examining the integrity and quality of extracellular vesicles along with other techniques either during isolation/preparation or for further engineering and storage. keywords: analysis; cell; exosomes; hplc; impurities; isolation; min; quality; samples; size; vesicles cache: jcb-2056.pdf plain text: jcb-2056.txt item: #23 of 80 id: jcb-2057 author: McKelvey, Kelly J.; Powell, Katie L.; Ashton, Anthony W.; Morris, Jonathan M.; McCracken, Sharon A. title: Exosomes: Mechanisms of Uptake date: 2015-07-17 words: 6897 flesch: 55 summary: Previous reviews have detailed exosome biogenesis, composition, and the cellular response of T cells to tumour- [2], dendritic cell (DC)- [3–5], and placenta-derived exosomes [6]. This may partially explain the systemic diffusion of exosomes to sites distant from the secreting cells, and how exosomes may come into contact with monocytes/macrophages, as well as T cells. keywords: antigen; biol; blood; cell; endocytosis; exosomes; fusion; human; immunol; internalization; j. cell; mechanisms; membrane; molecules; phagocytosis; plasma; proteins; response; signalling; surface; t cells; tetraspanins; vesicles cache: jcb-2057.pdf plain text: jcb-2057.txt item: #24 of 80 id: jcb-2058 author: Falana, Kimberly; Knight, Rob; Martin, Camilia R.; Goldszmid, Romina; Greathouse, K. Leigh; Gere, Joanne; Young, Howard; Kuo, Winston Patrick title: Short Course in the Microbiome date: 2015-07-27 words: 4869 flesch: 43 summary: Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Late last year, investigators from Mount Sinai associated a specific combination of gut bacteria with the development of colorectal cancer keywords: bacteria; cancer; cells; diversity; gut; human; knight; martin; microbes; microbial; microbiome; research; usa cache: jcb-2058.pdf plain text: jcb-2058.txt item: #25 of 80 id: jcb-2059 author: Sørensen, Patricia Diana; Andersen, Rikke Fredslund; Pallisgaard, Niels; Madsen, Jonna Skov; Jakobsen, Erik Hugger; Brandslund, Ivan title: Quantification of Cell-Free HER-2 DNA in Plasma from Breast Cancer Patients: Sensitivity for Detection of Metastatic Recurrence and Gene Amplification date: 2015-08-31 words: 6550 flesch: 52 summary: Conclusion: Amplified HER-2 DNA can be detected in plasma when using a ratio between cfHER-2 DNA and a reference gene. This study was performed on plasma samples from a previous prospective project, which was carried out on breast cancer patients in the period 2004–2009. keywords: breast; cancer; cfher-2; dna; gene; her-2; levels; patients; plasma; positive; ratio; samples; serum; tissue cache: jcb-2059.pdf plain text: jcb-2059.txt item: #26 of 80 id: jcb-2060 author: Zhao, Xuemei; Delgado, Liliana; Weiner, Russell; Laterza, Omar F. title: Influence of Pre-Analytical Factors on Thymus- and Activation-Regulated Chemokine Quantitation in Plasma date: 2015-10-27 words: 5584 flesch: 58 summary: TARC levels were quantitated in EDTA plasma samples from six subjects, prepared by low-speed centrifugation (1500 g): fresh plasma, fresh frozen plasma, and fresh frozen plasma samples following one, two, or three additional F-T cycles. 0 25 50 75 100 Fresh Fresh frozen 1 additional F-T 2 additional F-T 3 additional F-T TA R C ( pg /m L) P287M003K362K224K005A376 Fresh Fresh frozen 1 additional F-T 2 additional F-T 3 additional F-T TA R C ( pg /m L) P287M003K362K224K005A376 0 Fujisawa et al. reported TARC levels in EDTA plasma samples prepared by whole blood centrifugation at 1800 g keywords: blood; edta; edta plasma; freeze; levels; method; plasma; plasma samples; platelet; samples; serum; tarc; thaw cache: jcb-2060.pdf plain text: jcb-2060.txt item: #27 of 80 id: jcb-2062 author: Rather, Riyaz Ahmad; Saha, Subhas Chandra; Dhawan, Veena title: The Most Favourable Procedure for the Isolation of Cell-Free DNA from the Plasma of Iso-Immunized RHD-Negative Pregnant Women date: 2015-12-09 words: 4869 flesch: 57 summary: DNA recovered from maternal plasma of RHD negative iso- immunized women using different DNA isolation methods as measured by spectrophotometer Figure 1. DNA recovered from maternal plasma of RHD negative iso-immunized women using different DNA isolation methods as measured by real-time polymerase chain reaction 4 J Circ Biomark, 2015, 4:12 | doi: 10.5772/62113 equivalents of RHD, with mean values of 65.7±1.09 and 65.1±0.2, respectively (p>0.05). keywords: cell; cm1; concentration; dna; elution; globin; isolation; method; pcr; plasma; qiaamp; rhd; volume cache: jcb-2062.pdf plain text: jcb-2062.txt item: #28 of 80 id: jcb-2063 author: Arakelyan, Anush; Fitzgerald, Wendy; Vagida, Murad; Vasilieva, Elena; Margolis, Leonid; Grivel, Jean-Charles title: Addition of thrombin reduces the recovery of extracellular vesicles from blood plasma date: 2016-10-04 words: 4317 flesch: 47 summary: 2 Over the last several years, there is a growing interest in studying EVs as biological messengers and exploring their role as promising candidates for new poten- tial therapeutic and diagnostic tools. 3 In particular, blood EVs are now investigated as a factor in cardiovascular diseases. 2 Detailed analysis of EVs and their relevance to various pathologies requires EVs isolation and precise quantifica- tion. Various methods of EVs isolation have been described. keywords: antibodies; evs; exoquick; isolation; mhc; mnps; plasma; ppp; thrombin; vesicles cache: jcb-2063.pdf plain text: jcb-2063.txt item: #29 of 80 id: jcb-2064 author: Berezin, Alexander E; Kremzer, Alexander; Berezina, Tatyana; Martovitskaya, Yu title: The signature of circulating microparticles in heart failure patients with metabolic syndrome date: 2016-11-10 words: 8003 flesch: 48 summary: Alberti KGMM, Eckel RH, Grundy SM, et al. 3. Cornier MA, Dabelea D, Hernandez TL, et al. keywords: annexin; annexin vþ; cd31þ; cd62eþ; chf; endothelial; et al; metabolic; mets; microparticles; mps; p ¼; patients; ratio; risk; study cache: jcb-2064.pdf plain text: jcb-2064.txt item: #30 of 80 id: jcb-2065 author: Masci, Valentina Laghezza; Taddei, Anna Rita; Gambellini, Gabriella; Giorgi, Franco; Fausto, Anna Maria title: Microvesicles shed from fibroblasts act as metalloproteinase carriers in a 3-D collagen matrix date: 2016-11-07 words: 8060 flesch: 47 summary: Immunohistochemical localization of MMP-9 on collagen matrix following 1, 3, or 7 days of in vitro 3-D culture in the presence of fibroblasts. Phagocytosis and remo- deling of collagen matrices. keywords: anti; antibody; cell; collagen; culture; extracellular; fibroblasts; figure; gold; matrix; membrane; microvesicles; mmp-9; release; wound cache: jcb-2065.pdf plain text: jcb-2065.txt item: #31 of 80 id: jcb-2066 author: Abdouh, Mohamed; Hamam, Dana; Arena, Vincenzo; Arena, Manuel; Alamri, Hussam; Arena, Goffredo Orazio title: Novel blood test to predict neoplastic activity in healthy patients and metastatic recurrence after primary tumor resection date: 2016-11-09 words: 7635 flesch: 56 summary: Danova M, Torchio M and Mazzini G. Isolation of rare cir- culating tumor cells in cancer patients: technical aspects and clinical implications. Traditionally, metastasis is described as a multistage process initiated by cancer cells detachment from the pri- mary tumor site, circulation of the cells in the blood flow, with subsequent homing in distant sites for the establish- ment of secondary foci of disease. keywords: blood; cancer; cases; cells; crc; group; hek293; metastatic; patients; platform; post; resection; sera; serum; som; test; tumor cache: jcb-2066.pdf plain text: jcb-2066.txt item: #32 of 80 id: jcb-2067 author: Bustamante, Alejandro; Mancha, Fernando; Macher, Hada C; García-Berrocoso, Teresa; Giralt, Dolors; Ribó, Marc; Guerrero, Juan M; Montaner, Joan title: Circulating cell-free DNA is a predictor of short-term neurological outcome in stroke patients treated with intravenous thrombolysis date: 2016-09-26 words: 3768 flesch: 44 summary: CBX668791 1..6 Research Article Circulating cell-free DNA is a predictor of short-term neurological outcome in stroke patients treated with intravenous thrombolysis Alejandro Bustamante1, Fernando Mancha2, Hada C Macher3, Teresa Garcı́a-Berrocoso1, Dolors Giralt1, Marc Ribó4, Juan M Guerrero3, and Joan Montaner1,2 Abstract Circulating cell-free DNA (cfDNA) has been described as a prognostic marker for several diseases. Its prognostic value for short-term outcome in stroke patients treated with intravenous thrombolysis remains unexplored. keywords: baseline; cell; cfdna; improvement; levels; outcome; patients; stroke; tpa cache: jcb-2067.pdf plain text: jcb-2067.txt item: #33 of 80 id: jcb-2068 author: Gaziev, Azhub; Abdullaev, Serazhutdin; Minkabirova, Gulchachak; Kamenskikh, Kristina title: X-rays and metformin cause increased urinary excretion of cell-free nuclear and mitochondrial DNA in aged rats date: 2016-10-25 words: 6507 flesch: 51 summary: Figure 2 represents examples of kinetic curves of qPCR for cf-mtDNA and cf-nDNA from rat urine collected before irradiation. Electrophoresis of DNA extracted from rat urine, 1% agarose gel. keywords: administration; autophagy; cell; death; dna; increase; irradiation; metformin; mtdna; ndna; rats; results; urine cache: jcb-2068.pdf plain text: jcb-2068.txt item: #34 of 80 id: jcb-2069 author: Søndergaard, Evo K. Lindersson; Pugholm, Lotte Hatting; Bæk, Rikke; Jørgensen, Malene Møller; Revenfeld, Anne Louise Schacht; Varming, Kim title: Oxygen-Related Differences in Cellular and Vesicular Phenotypes Observed for Ovarian Cell Cancer Lines date: 2016-01-22 words: 8199 flesch: 58 summary: The phenotyping of EVs from cancer cell lines provides information about their molecular composition. The hypoxia-induced release of EVs from cancer cells has been hypothesized to cause the malignant transformation of healthy recipient cells. keywords: cancer; cd81; cd9; cell; cell lines; conditions; cov504; evs; expression; hours; hypoxic; hypoxic conditions; internet; lines; markers; normoxic; nov; ovarian; skov3; tumour; vesicles cache: jcb-2069.pdf plain text: jcb-2069.txt item: #35 of 80 id: jcb-2070 author: Jia, Shidong; Chiesi, Antonio; Kuo, Winston Patrick title: Onward to 2016 date: 2016-01-28 words: 914 flesch: 28 summary: This was attributable to the number of quality published original research articles in 2015 with the help of our Associate Editors and Editorial Board. JCB has arranged a discount for our readers when registering for SelectBio and CHI events, which by the way, have many presenters that are members of our Associate Editors and Editorial Board. keywords: board; editorial; jcb; microbiome cache: jcb-2070.pdf plain text: jcb-2070.txt item: #36 of 80 id: jcb-2071 author: Lepone, Lauren M.; Donahue, Renee N.; Grenga, Italia; Metenou, Simon; Richards, Jacob; Heery, Christopher R.; Madan, Ravi A.; Gulley, James L.; Schlom, Jeffrey title: Analyses of 123 Peripheral Human Immune Cell Subsets: Defining Differences with Age and between Healthy Donors and Cancer Patients Not Detected in Analysis of Standard Immune Cell Types date: 2016-03-10 words: 12437 flesch: 58 summary: Moreover, we have identi‐ fied differences among immune cell subsets expressing molecules on their surface that are the targets of existing checkpoint inhibitor therapies such as CTLA-4, PD-1 and PD-L1, as well as other potential targets for which immu‐ notherapies are being developed. Differences in immune cell subsets related to maturation and function between healthy donors under and over the age of 40. keywords: activation; age; analysis; b cells; blood; cancer; cancer patients; cd4; cd8; cell subsets; cell types; ctla-4; differences; donors; figure; function; immune; markers; maturation; nk cells; patients; pbmcs; pd-1; subsets; t cells; types cache: jcb-2071.pdf plain text: jcb-2071.txt item: #37 of 80 id: jcb-2072 author: Wachalska, Magda; Koppers-Lalic, Danijela; van Eijndhoven, Monique; Pegtel, Michiel; Geldof, Albert A.; Lipinska, Andrea D.; van Moorselaar, R. Jeroen; Bijnsdorp, Irene V. title: Protein Complexes in Urine Interfere with Extracellular Vesicle Biomarker Studies date: 2016-03-01 words: 3729 flesch: 59 summary: The number of EVs in the THP pellet was slightly increased after storage at -80˚C, as well as the presence of THP-complexes, compared to urine storage at 4˚C, indicating that THP reduced EV isolation to Figure 1 - Wachalska et al. D. Western blot showing the expression of THP, TSG101 and CD63 in extracellular vesicles and THP fraction. keywords: evs; figure; fraction; isolation; levels; mir-21; mir-375; protein; thp; urine; vesicles cache: jcb-2072.pdf plain text: jcb-2072.txt item: #38 of 80 id: jcb-2073 author: Revenfeld, Anne Louise Schacht; Søndergaard, Evo Kristina Lindersson; Stensballe, Allan; Bæk, Rikke; Jørgensen, Malene Møller; Varming, Kim title: Characterization of a Cell-Culturing System for the Study of Contact-Independent Extracellular Vesicle Communication date: 2016-02-26 words: 6444 flesch: 53 summary: For each combination of responder and stimulator cells in the UC and the LC, the bars show a mean value ± SEM from two independent experiments using cells from the same two donors. 2.2 Contact-independent cell communication Isolation of cells: Buffy coats were obtained from healthy blood donors at the Aalborg University Hospital blood bank. keywords: array; cell; communication; compartment; culture; culturing; evs; exchange; figure; set; signal; vesicles cache: jcb-2073.pdf plain text: jcb-2073.txt item: #39 of 80 id: jcb-2074 author: Berezin, Alexander E. title: Prognostication in Different Heart Failure Phenotypes: The Role of Circulating Biomarkers date: 2016-03-16 words: 5486 flesch: 54 summary: Comparison of fibroblast growth factor 23, soluble ST2 and Galectin-3 for prognostication of cardio‐ vascular death in heart failure patients. Soluble ST2 may possess special superiority as a risk predictor in heart failure patients. keywords: 2015; biomarkers; cardiac; disease; ejection; failure; fraction; galectin-3; heart; heart failure; hfpef; patients; risk; role; soluble cache: jcb-2074.pdf plain text: jcb-2074.txt item: #40 of 80 id: jcb-2075 author: Nagarajah, Sivappriyan title: Exosome Secretion — More Than Simple Waste Disposal? Implications for Physiology, Diagnostics and Therapeutics date: 2016-04-01 words: 6127 flesch: 58 summary: [44-46] – exosomes add to the Darwinian para‐ digm of cancer cells as an evolving agent, with those capable of manipulating the cell machinery gaining a clear advantage in self- propagation. Whilst exosomes from DCs can be immunostimulatory, cancer cell exosomes contain both cancer cell antigens, that could potentially be used to activate the immune system, and immunosuppressive molecules in vivo. keywords: biology; biomarkers; blood; cancer; cell; dcs; diagnostics; disease; et al; exosomal; exosomes; journal; medicine; patients; physiology; plasma; proteins; research; secretion; vesicles; work cache: jcb-2075.pdf plain text: jcb-2075.txt item: #41 of 80 id: jcb-2076 author: Hiwasa, Takaki; Zhang, Xiao-Meng; Kimura, Risa; Ohno, Mikiko; Chen, Po-Min; Nishi, Eiichiro; Ono, Koh; Kimura, Takeshi; Kamitsukasa, Ikuo; Wada, Takeshi; Aotsuka, Akiyo; Mine, Seiichiro; Takizawa, Hirotaka; Kashiwado, Koichi; Takemoto, Minoru; Kobayashi, Kazuki; Kawamura, Harukiyo; Ishibashi, Ryoichi; Yokote, Koutaro; Nakamura, Rika; Tomiyoshi, Go; Shinmen, Natsuko; Kuroda, Hideyuki title: Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus date: 2016-04-07 words: 3977 flesch: 56 summary: [23], whereas the concentration of adiponectin autoantibodies may be much lower. The table shows averages, SDs, cut-off values (average + 2SD), total sample numbers, the numbers of positive sera of which antibody levels were higher than the cut-off value and the positive rates (%) of the HD subjects; averages, SDs, total sample numbers, numbers of positive sera of which the antibody levels were higher than the cut-off value and the positive rates (%) of patients; and P values of the statistical comparison between the HD subjects and patients. keywords: abs; aci; adiponectin; antibody; cad; chiba; diseases; hd subjects; levels; patients; subjects cache: jcb-2076.pdf plain text: jcb-2076.txt item: #42 of 80 id: jcb-2077 author: Berggrund, Malin; Ekman, Daniel; Gustavsson, Inger; Sundfeldt, Karin; Olovsson, Matts; Enroth, Stefan; Gyllensten, Ulf title: Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card™ date: 2016-01-01 words: 5021 flesch: 60 summary: Protein Plasma (% of samples over LOD) 24 h (% of samples over LOD) 72 h (% of samples over LOD) IL-8 100% 100% 100% VEGF-A 100% 100% 100% AM 100% 100% 100% GDF-15 100% 100% 100% PlGF 100% 100% 100% CSF-1 100% 100% 100% CSTB 100% 100% 100% MCP-1 100% 100% 100% KLK6 100% 100% 100% TRAIL-R2 100% 100% 100% LAP-TGF-beta-1 100% 100% 100% TF 100% 100% 100% TNF-R1 100% 100% 100% PDGF-subunit-B 100% 100% 100% PARK7 100% 100% 100% CXCL11 100% 100% 100% VE-statin 100% 100% 100% IL-7 100% 100% 100% SCF 100% 100% 100% CXCL9 100% 100% 100% TNF-R2 100% 100% 100% TNFSF14 100% 100% 100% GH 100% 100% 100% FasL 100% 100% 100% FAS 100% 100% 100% CCL19 100% 100% 100% EMMPRIN 100% 100% 100% CXCL10 100% 100% 100% Ep-CAM 100% 100% 100% HGF 100% 100% 100% LITAF 100% 100% 100% CXCL5 100% 100% 100% MK 100% 100% 100% U-PAR 100% 100% 100% CDH3 100% 100% 100% LYN 100% 100% 100% Flt3L 100% 100% 100% HB-EGF 100% 100% 100% CD69 100% 100% 100% TR-AP 100% 100% 100% CDKN1A 100% 100% 100% REG-4 100% 100% 100% 3Malin Berggrund, Daniel Ekman, Inger Gustavsson, Karin Sundfeldt, Matts Olovsson, Stefan Enroth and Ulf Gyllensten: Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card™ Protein Plasma (% of samples over LOD) 24 h (% of samples over LOD) 72 h (% of samples over LOD) VEGF-D 100% 100% 100% HE4 100% 100% 100% CXCL13 100% 100% 100% CA-125 100% 100% 100% PRSS8 100% 100% 100% PECAM-1 100% 100% 100% FR-alpha 100% 100% 100% TIE2 100% 100% 80% MIC-A 100% 100% 80% IL-6 100% 100% 60% ICOSLG 100% 100% 60% FS 100% 100% 60% NTRK3 100% 100% 20% ILT-3 100% 80% 80% VEGFR-2 100% 80% 80% ITGA1 100% 80% 80% ErbB3-HER3 keywords: card; detection; elute; fta; fta elute; lod; micro; plasma; proteins; samples cache: jcb-2077.pdf plain text: jcb-2077.txt item: #43 of 80 id: jcb-2079 author: Woo, JungReem; Sharma, Shivani; Gimzewski, James title: The Role of Isolation Methods on a Nanoscale Surface Structure and its Effect on the Size of Exosomes date: 2016-01-01 words: 6538 flesch: 50 summary: However, IA exosomes had higher surface roughness and bimodal size population compared to UC exosomes. High-resolution images of UC exosomes obtained by AFM imaging in air; (a) representative topography, (b) amplitude and (c) phase images of exosomes. keywords: cell; exosomes; figure; height; ia exosomes; isolation; methods; size; surface; vesicles cache: jcb-2079.pdf plain text: jcb-2079.txt item: #44 of 80 id: jcb-2080 author: Markowska, Anna; Pendergrast, R. Scott; Pendergrast, J Stephen; Pendergrast, P Shannon title: A novel method for the isolation of extracellular vesicles and RNA from urine date: 2017-06-12 words: 3960 flesch: 39 summary: Results The Ymir Genomics EV isolation method has a simple and rapid protocol (Figure 1).To determine its efficacy, a healthy volunteers sample was divided into two and pro- cessed by the Ymir Genomics protocol and by a standard UC protocol. EV isolation EVs were isolated from urine samples using Ymir Geno- mics’ EV Isolation Kit (Ymir Genomics, Cambridge, Mas- sachusetts, USA), miRCURY Exosome Isolation Kit (Exiqon, Woburn, Massachusetts, USA), ExoQuick-TC (SBI, Mountain View, California, USA), and Total Exo- some Isolation Reagent (Life Technologies, Carlsbad, Cali- fornia, USA) following manufacturers’ directions. keywords: evs; figure; genomics; isolation; kit; method; sample; urine; usa; ymir cache: jcb-2080.pdf plain text: jcb-2080.txt item: #45 of 80 id: jcb-2081 author: Guerrico, Anatilde Gonzalez; Hillman, David; Karnes, Jeffery; Davis, Brian; Gaston, Steven; Klee, George title: Roles of kallikrein-2 biomarkers (free-hK2 and pro-hK2) for predicting prostate cancer progression-free survival date: 2017-07-19 words: 6443 flesch: 56 summary: Pro-hK2 assay and free-hK2 assay analytical performance. Pro-hK2 assay development. keywords: cancer; clinical; free; gleason; hk2; progression; prostate; psa; score cache: jcb-2081.pdf plain text: jcb-2081.txt item: #46 of 80 id: jcb-2082 author: Kawamoto, Ryuichi; Ninomiya, Daisuke; Senzaki, Kensuke; Kumagi, Teru title: Mildly elevated serum total bilirubin is negatively associated with hemoglobin A1c independently of confounding factors among community-dwelling middle-aged and elderly persons date: 2017-08-17 words: 4984 flesch: 50 summary: Kimm H, Yun JE, Jo J, et al. Low serum bilirubin level as an independent predictor of stroke incidence: a prospective study in Korean men and women. Data for triglycerides, hemoglobin A1c, and serum total bilirubin were skewed, presented as median (interquartile range) values, and log-transformed for analysis. keywords: bilirubin; factors; hba1c; men; serum; serum t cache: jcb-2082.pdf plain text: jcb-2082.txt item: #47 of 80 id: jcb-2083 author: Saghiv, Moran S; Sira, D Ben; Goldhammer, E; Sagiv, M title: The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients date: 2017-09-26 words: 7057 flesch: 54 summary: 43,44 As a first step to probe the connection between physical activity, age, and Klotho expression, Schefer et al. 43 quan- tified the effect of an acute exercise bout on circulating Klotho levels in mice. Avin et al. 9 evaluated in young and older sedentary women the change in circulating Klotho levels before and after completion of an acute aerobic exercise bout. keywords: adults; aging; cad; disease; et al; exercise; growth; igf; insulin; klotho; klotho levels; levels; muscle; patients; protein; training cache: jcb-2083.pdf plain text: jcb-2083.txt item: #48 of 80 id: jcb-2084 author: Kuo, Winston Patrick title: Journal of Circulating Biomarkers looks forward after being indexed in PubMed Central date: 2017-12-11 words: 1187 flesch: 23 summary: https://uk.sagepub.com/en-gb/journals-permissions https://doi.org/10.1177/1849454417745757 http://journals.sagepub.com/home/cbx https://us.sagepub.com/en-us/nam/open-access-at-sage << /ASCII85EncodePages false /AllowTransparency false /AutoPositionEPSFiles true /AutoRotatePages /None /Binding /Left /CalGrayProfile << /TileWidth 256 /TileHeight 256 /Quality 30 >> /AntiAliasMonoImages false /CropMonoImages false /MonoImageMinResolution 900 /MonoImageMinResolutionPolicy keywords: editors; jcb; journal; pubmed cache: jcb-2084.pdf plain text: jcb-2084.txt item: #49 of 80 id: jcb-2085 author: Nair, Nandini; Gongora, Enrique title: Correlations of GDF-15 with sST2, MMPs, and worsening functional capacity in idiopathic dilated cardiomyopathy Can we gain new insights into the pathophysiology? date: 2018-01-18 words: 4977 flesch: 47 summary: Elliott P, Andersson B, Arbustini E, et al. Classification of the cardiomyopathies: a position statement from the Eur- opean Society of Cardiology working group on myocardial and pericardial diseases. 2. Mestroni L, Brun F, Spezzacatene A, et al. keywords: correlation; gdf-15; heart; lvef; lvidd; mmp2; p ¼; sst2; timp1 cache: jcb-2085.pdf plain text: jcb-2085.txt item: #50 of 80 id: jcb-2086 author: Song, Jianlu; Yang, Zhili title: Whole exome sequencing of circulating cell-free tumor DNA in a follicular thyroid carcinoma patient with lung and bone metastases date: 2018-03-23 words: 3306 flesch: 49 summary: Tissue somatic mutation genes cfDNA somatic mutation genes Intersection (31%) Outline of the WES of cfDNA, tumor DNA, and peripheral blood DNA. keywords: blood; cancer; cfdna; dna; ftc; mutations; samples; sequencing; thyroid; tissue; tumor; variants cache: jcb-2086.pdf plain text: jcb-2086.txt item: #51 of 80 id: jcb-2087 author: Alkhatatbeh, Mohammad J; Enjeti, Anoop K; Baqar, Sara; Ekinci, Elif I; Liu, Dorothy; Thorne, Rick F; Lincz, Lisa F title: Strategies for enumeration of circulating microvesicles on a conventional flow cytometer Counting beads and scatter parameters date: 2018-04-04 words: 6888 flesch: 50 summary: Events were collected for 60 s (bead experi- ments) or 120 s (patient samples; to enable adequate num- ber of counting bead events 19 ) at low flow rate prior to analysis using FACS Diva software (BD Biosciences). Correlation between the number of bead events counted versus added to each test and MV events counted using different brands of absolute counting beads. keywords: analysis; beads; counting; cytometry; events; flow; fsc; number; parameter; plasma; ssc cache: jcb-2087.pdf plain text: jcb-2087.txt item: #52 of 80 id: jcb-2088 author: Nallagangula, Krishna Sumanth; Shashidhar, KN; Lakshmaiah, V; Muninarayana,   title: Evolution of proteomic biomarker for chronic liver disease Promise into reality date: 2018-05-21 words: 6295 flesch: 32 summary: Discovery of protein biomarker; protocol for the development of protein biomarker candidate. Pharmacody- namic biomarker gives interaction between drug and tar- get. 6,7 In this review, an attempt has been made to understand the process of proteomic biomarker develop- ment which includes protein biomarker discovery, valida- tion, and pitfalls in biomarker pipeline for CLD. keywords: biomarker; biomarker discovery; candidates; cld; clinical; development; diagnostic; discovery; disease; liver; protein; protein biomarker; proteomics; research; sample; serum; validation cache: jcb-2088.pdf plain text: jcb-2088.txt item: #53 of 80 id: jcb-2089 author: Jain, Ram B; Ducatman, Alan title: Associations between smoking and lipid/lipoprotein concentrations among US adults aged ≥20 years date: 2018-05-30 words: 8300 flesch: 62 summary: http://orcid.org/0000-0002-3278-7106 http://orcid.org/0000-0002-3278-7106 mailto:jain.ram.b@gmail.com https://uk.sagepub.com/en-gb/journals-permissions https://doi.org/10.1177/1849454418779310 http://journals.sagepub.com/home/cbx https://us.sagepub.com/en-us/nam/open-access-at-sage further modified in relationship to their smoking status, with 18.8%, 17.3%, and 36.4% among nonsmokers, former smokers, and current smokers, respectively, but TG levels were not found to differ among these groups when visceral area was <100 cm 2 . 7 Thus, an interaction between smoking and body fat distribution was found to affect TG levels. Data on demographics, body measures, physical activity, serum cotinine, total nutrient intake, HDL, LDL, TC, and TG levels were downloaded and match merged. keywords: hdl; ldl; levels; nhb; p ¼; smoking cache: jcb-2089.pdf plain text: jcb-2089.txt item: #54 of 80 id: jcb-2090 author: Po, Joseph W; Roohullah, Aflah; Lynch, David; DeFazio, Anna; Harrison, Michelle; Harnett, Paul R; Kennedy, Catherine; Kennedy, Catherine; de Souza, Paul; Becker, Therese M title: Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin date: 2018-06-22 words: 7065 flesch: 47 summary: In this study, we tested a cohort of ovarian cancer cell lines using flow cytometry to identify N-cadherin as the additional immunomagnetic cell surface target for ovarian cancer cell isolation. Bottom: ovarian cancer patient cells were isolated by EpCAM, N-cadherin (N-cad), or combined targeting as indicated. keywords: blood; cadherin; cancer; cecs; cells; ctc; ctcs; emt; epcam; epithelial; isolation; ovarian; patients; targeting cache: jcb-2090.pdf plain text: jcb-2090.txt item: #55 of 80 id: jcb-2091 author: Gadde, Ranjeeta; CD, Dayanand; Sheela, SR title: Placental protein 13 An important biological protein in preeclampsia date: 2018-07-12 words: 12931 flesch: 53 summary: 34,35 The placental gene LGALS13 located on the long arm of chromosome 19 at loci q13.2 encodes PP13 protein exclusively. 36 LGALS13 gene and its transcribing unit codes for PP13 at 50 end that has promoter region followed by comprising four exons designated as E1–E4 (Figure 1). The frequency of maternal PP13 was also lower in the preeclamptic group (28%) compared to that in the control group (76%), with a highly statistically signif- icant difference (p < 0.0001). keywords: binding; blood; blood group; case; cell; control; et al; expression; galectin; group; human; immune; levels; lgals13; maternal; placental; placental protein; placentation; pp13; preeclampsia; pregnancy; protein; research; risk; role; serum; studies; study; syncytiotrophoblast; trimester; weeks; women cache: jcb-2091.pdf plain text: jcb-2091.txt item: #56 of 80 id: jcb-2092 author: Nallagangula, Krishna Sumanth; Lakshmaiah, V; Muninarayana, C; Deepa, KV; Shashidhar, KN title: A proteomic approach of biomarker candidate discovery for alcoholic liver cirrhosis date: 2018-07-13 words: 6679 flesch: 39 summary: Protein biomarker candidates identified by “-omics” approach based on differential expression between alcoholic liver cirrhotic subjects and healthy subjects may give better insights for diagnosis of ALD. Keywords Alcoholic liver cirrhosis, protein biomarker candidates, albumin depletion, two-dimensional electrophoresis, liquid chromatography–mass spectrometry Date received: 13 March 2018; accepted: 15 June 2018 Introduction Cirrhosis of the liver is the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, leading to portal hyperten- sion and end-stage liver disease. keywords: albumin; alcoholic; ald; analysis; biomarker; biomarker candidates; candidates; cirrhosis; depletion; discovery; disease; expression; gel; liver; min; protein; samples; serum; subjects cache: jcb-2092.pdf plain text: jcb-2092.txt item: #57 of 80 id: jcb-2093 author: Tan, Sven-Jean; Chu, Melissa M; Toussaint, Nigel D; Cai, Michael MX; Hewitson, Tim D; Holt, Stephen G title: High-intensity physical exercise increases serum α-klotho levels in healthy volunteers date: 2018-08-16 words: 5782 flesch: 54 summary: sKl, sPi, and blood glucose levels were measured in samples collected 1-week prior, immediately pre (Tpre), 0 (Tpost), 30 (T30), 240 (T240) min, and 1-week after exercise. 2 Journal of Circulating Biomarkers Baseline tests for hemoglobin, blood glucose level, serum biochemistry, and klotho were measured immedi- ately prior to exercise intervention (Tpre). keywords: blood; est; et al; exercise; glucose; intensity; klotho; levels; participants; serum; skl; spi; study; tpost; tpre cache: jcb-2093.pdf plain text: jcb-2093.txt item: #58 of 80 id: jcb-2094 author: Carrillo-Ibarra, Sandra; Miranda-Díaz, Alejandra Guillermina; Sifuentes-Franco, Sonia; Cardona-Muñoz, Ernesto Germán; Rodríguez-Carrizalez, Adolfo Daniel; Villegas-Rivera, Geannyne; Román-Pintos, Luis Miguel title: Effect of statins on oxidative DNA damage in diabetic polyneuropathy date: 2018-10-01 words: 5016 flesch: 52 summary: SOD levels in healthy subjects were 9.81 U/mL (8.66– 12.61) versus 5.35 U/mL (0.01–17.90) in DPN patients (p < 0.001). Dinçer Y, Akçay T, Alademir Z, et al. keywords: diabetes; dna; dpn; group; levels; patients; rosuvastatin; simvastatin cache: jcb-2094.pdf plain text: jcb-2094.txt item: #59 of 80 id: jcb-2096 author: Safwat, A; Sabry, D; Ragiae, A; Amer, E; Mahmoud, RH; Shamardan, RM title: Adipose mesenchymal stem cells–derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits date: 2018-10-25 words: 6728 flesch: 47 summary: In conclusion, adipose MSCs-derived exosomes act as biological mediators in retinal tissue repair through its role in delivering micRNA-222 to retinal cells. Fong DS, Aiello L, Gardner TW, et al. keywords: cells; diabetic; exosomes; expression; figure; group; layer; micrna-222; mscs; retina; stem; tissue cache: jcb-2096.pdf plain text: jcb-2096.txt item: #60 of 80 id: jcb-2097 author: Ma, Bennett; Wesolowski, Gregg; Luo, Bin; Lifsted, Traci; Wessner, Keith; Adamson, Gary; Glantschnig, Helmut; Lubbers, Laura S title: Suppression of cathepsin K biomarker in synovial fluid as a free-drug–driven process date: 2019-01-07 words: 3568 flesch: 38 summary: Reasonable prediction (within twofold) was observed in the current study as well as data reported by Wang et al. 11 and Day et al., 14 confirm- ing the feasibility of the current approach to estimate drug level in synovial fluid based on plasma drug concentration and the unbound fraction of drug in plasma. The drug levels in synovial fluid and cartilage can be reasonably estimated based on plasma drug concentration with adjust- ments for binding factors. keywords: biomarker; cartilage; concentration; dose; drug; fluid; mk-1256; plasma; synovial cache: jcb-2097.pdf plain text: jcb-2097.txt item: #61 of 80 id: jcb-2098 author: Lepedda, Antonio Junior; Deiana, Giovanni Andrea; Lobina, Omar; Nieddu, Gabriele; Baldinu, Paola; De Muro, Pierina; Andreetta, Francesca; Sechi, Elia; Arru, Giannina; Corda, Davide Giacomo; Sechi, Gian Pietro; Formato, Marilena title: Plasma vitronectin is reduced in patients with myasthenia gravis: Diagnostic and pathophysiological potential date: 2019-09-11 words: 6190 flesch: 44 summary: To this end, we applied 2-DE coupled with MS, which allows for comparing the expression/abundance of hundreds of proteins at the same time, to identify differen- tially expressed plasma proteins between MG patients and healthy controls, following plasma enrichment of low- abundance protein components. MG patients (c), and DSN MG patients (d) after mass compatible Coomassie Brillant Blue G-250 staining. keywords: analysis; controls; disease; dsn; gravis; mg patients; myasthenia; patients; plasma; proteins; receptor; vitronectin cache: jcb-2098.pdf plain text: jcb-2098.txt item: #62 of 80 id: jcb-2099 author: Chen, Suming; Datta-Chaudhuri, Amrita; Deme, Pragney; Dickens, Alex; Dastgheyb, Raha; Bhargava, Pavan; Bi, Honghao; Haughey, Norman J title: Lipidomic characterization of extracellular vesicles in human serum date: 2019-09-30 words: 9876 flesch: 55 summary: Verkhratsky A, Matteoli M, Parpura V, et al. Tucher C, Bode K, Schiller P, et al. keywords: analysis; dag; data; et al; evs; extracellular; features; fractions; lipid; number; pellet; protein; serum; species; tag; vesicles cache: jcb-2099.pdf plain text: jcb-2099.txt item: #63 of 80 id: jcb-2100 author: Gupta, Pratyush; Gulzar, Zulfiqar; Hsieh, Ben; Lim, Austin; Watson, Drew; Mei, Rui title: Analytical validation of the CellMax platform for early detection of cancer by enumeration of rare circulating tumor cells date: 2019-12-31 words: 9056 flesch: 52 summary: This report provides assay performance data, including accuracy, linearity, limit of blank, limit of detection (LOD), spe- cificity, and precision of enumeration of cancer cell line cells (CLCs) spiked in cell culture medium or healthy donor blood samples. CTC: circulating tumor cell; CLC: cancer cell line cell. keywords: assay; blood; cancer; cells; chip; cmx; concentrations; counts; ctc; ctcs; detection; efficiency; medium; patient; recovery; samples; spiked; tumor cache: jcb-2100.pdf plain text: jcb-2100.txt item: #64 of 80 id: jcb-2121 author: Bogie, Kath M; Schwartz, Katelyn; Li, Youjin; Wang, Shengxuan; Dai, Wei; Sun, Jiayang title: Exploring adipogenic and myogenic circulatory biomarkers of recurrent pressure injury risk for persons with spinal cord injury date: 2020-09-21 words: 5323 flesch: 54 summary: Exploring adipogenic and myogenic circulatory biomarkers of recurrent pressure injury risk for persons with spinal cord injury Kath M. Bogie1,2, Katelyn Schwartz2, Youjin Li3, Shengxuan Wang3, Wei Dai3, Jiayang Sun4 1Case Western Reserve University, Departments of Orthopaedics and Biomedical Engineering, Cleveland, Ohio - USA 2Louis Stokes Cleveland Veterans Affairs Medical Center (LSCVAMC), Research Service, Cleveland, Ohio - USA 3Case Western Reserve University, Department of Population & Quantitative Health Sciences, Cleveland, Ohio - USA 4Department of Statistics, George Mason University, Fairfax, Virginia - USA ABSTRACT Purpose: To investigate linkages between circulatory adipogenic and myogenic biomarkers, gluteal intramuscular adipose tissue (IMAT), and pressure injury (PrI) history following spinal cord injury (SCI). Biomarkers for recurrent pressure injury risk in persons with spinal cord injury. keywords: adipogenesis; analysis; biomarkers; cord; data; genes; imat; injury; models; muscle; pressure; pri; rpri; sci; spinal; tab; tissue cache: jcb-2121.pdf plain text: jcb-2121.txt item: #65 of 80 id: jcb-2163 author: Lu, David; Krupa, Rachel; Harvey, Melissa; Graf, Ryon P.; Schreiber, Nicole; Barnett, Ethan; Carbone, Emily; Jendrisak, Adam; Gill, Audrey; Orr, Sarah; Scher, Howard I; Schonhoft, Joseph Daniel title: Development of an immunofluorescent AR-V7 circulating tumor cell assay – A blood-based test for men with metastatic prostate cancer date: 2020-10-23 words: 5307 flesch: 51 summary: However, other mechanisms of resistance exist, including other forms of AR reactivation, AR bypass signaling, and AR independent disease (20), and it is likely that AR-V7 expression may co- occur with many, highlighting the need for more comprehen- sive biomarkers that can be assessed in real time. 22RV1 cells are known to express seve- ral AR splice variants (14), and because of this heterogeneity, mRNA transcripts corresponding to the ARNTD-, ARV7CE-, and ARCTD-specific sequences were detected, reconfir- ming the expression of both full-length AR and AR-V7 splice variants (Fig. 1A). keywords: assay; blood; cancer; cell; ctcs; expression; nuclear; patients; prostate; protein; samples cache: jcb-2163.pdf plain text: jcb-2163.txt item: #66 of 80 id: jcb-2164 author: Domingo, Mar; Conangla, Laura; Lupon, Josep; Wilke, Asunción; Juncà, Gladys; Revuelta-López, Elena; Tejedor, Xavier; Bayes-Genis, Antoni title: Lung ultrasound and biomarkers in primary care: Partners for a better management of patients with heart failure? date: 2020-10-16 words: 3248 flesch: 53 summary: Although larger studies in diverse populations are needed, our data are hypotheses generating correlations between B-lines, a surrogate of pulmonary congestion, and of biomar- kers in HF patients. Primary care patients with suspected new-onset nonacute HF were evaluated both with a 12-scan LUS protocol (8 anterolateral areas plus 4 lower posterior thoracic areas) and 11 inflammatory and cardiovascular biomarkers. keywords: biomarkers; diagnosis; heart; line; patients; sum; total cache: jcb-2164.pdf plain text: jcb-2164.txt item: #67 of 80 id: jcb-2194 author: Macías-Muñoz, Laura; Wijngaard, Robin; González-de la Presa, Bernardino; Bedini, Jose Luis; Morales-Ruiz, Manuel; Jiménez, Wladimiro title: Value of clinical laboratory test for early prediction of mortality in patients with COVID-19: the BGM score date: 2021-02-08 words: 6022 flesch: 56 summary: Finally, the BGM score surpassed the prediction accu- racy performance of the independent multivariate models, yielding a sensitivity of 73.7%, a specificity of 96.5%, a kappa of 0.74, and a balanced accuracy of 0.85. Conclusions: The BGM score may support clinicians in managing COVID-19 patients and providing focused inter- ventions to those with an increased risk of mortality. Other studies have been published using machine learning models to predict the mortality in COVID-19 patients, and some of them were included in systematic reviews and meta- analysis (31). keywords: bgm; covid-19; crossref; crp; disease; laboratory; model; mortality; patients; pubmed; score; study cache: jcb-2194.pdf plain text: jcb-2194.txt item: #68 of 80 id: jcb-2212 author: Barchiesi, Vittoria; Simeon, Vittorio; Sandomenico, Claudia; Cantile, Monica; Cerasuolo, Dionigio; Chiodini, Paolo; Morabito, Alessandro; Cavalcanti, Ernesta title: Circulating progastrin-releasing peptide in the diagnosis of Small Cell Lung Cancer (SCLC) and in therapeutic monitoring date: 2021-07-07 words: 3765 flesch: 58 summary: Moreover, 50 cases of healthy subjects were analyzed for proGRP. SCLC patients showed a significantly higher proGRP (1,484 pg/mL; range 168-3,777) levels compared to NSCLC patients (45 pg/mL; range 31.7-60.6), p<0.0001. Results ProGRP serum level in lung cancer patients A total of 77 patients affected by lung cancer, 17 SCLC and 60 NSCLC, were enrolled in the present study between July 2015 and July 2017; moreover, 50 cases of healthy subjects were collected from the Unit of Transfusional Medicine, at the National Cancer Institute “G. Pascale” of Naples, Italy. keywords: cancer; cell; lung; nse; patients; peptide; progrp; sclc cache: jcb-2212.pdf plain text: jcb-2212.txt item: #69 of 80 id: jcb-2220 author: Schreier, Stefan; Budchart, Prapaphan; Borwornpinyo, Suparerk; Arpornwirat, Wichit; Triampo, Wannapong title: Circulating erythroblast abnormality associated with systemic pathologies may indicate bone marrow damage date: 2021-08-31 words: 4643 flesch: 50 summary: Bone marrow damage has been associated with aggressive or late-stage systemic diseases and egress of various bone marrow cells into the blood circulation. Schreier S, Borwornpinyo S, Udomsangpetch R, Triampo W. An update of circulating rare cell types in healthy adult peripheral blood: findings of immature erythroid precursors. keywords: blood; bmd; bone; cancer; ceb; cells; crossref; erythroblast; marrow; stage; tumor; type cache: jcb-2220.pdf plain text: jcb-2220.txt item: #70 of 80 id: jcb-2327 author: Erfurt, Stefan; Hoffmeister, Meike; Oess, Stefanie; Asmus, Katharina; Ritter, Oliver; Patschan, Susann; Patschan, Daniel title: Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification? date: 2021-11-30 words: 5335 flesch: 55 summary: Gungor O, Unal HU, Guclu A, et al. IL-33 and ST2 levels in chronic kidney disease: associations with inflammation, vas- cular abnormalities, cardiovascular events, and survival. Hasan A, Al-Ghimlas F, Warsame S, et al. IL-33 is negatively as- sociated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects. keywords: biomarker; cancer; colleagues; controls; crossref; cytokine; disease; et al; il-33; interleukin-33; kidney; levels; patients; serum; study; subjects cache: jcb-2327.pdf plain text: jcb-2327.txt item: #71 of 80 id: jcb-2328 author: Albanese, Luisa; Caliendo, Gemma; D'Elia, Giovanna; Passariello, Luana; Molinari, Anna Maria; Napoli, Claudio; Vietri, Maria Teresa title: Diagnostic utility of FGF-23 in mineral bone disorder during chronic kidney disease date: 2022-01-08 words: 2981 flesch: 53 summary: Stage I (n = 10) 2/10 (20%) – – Stage II (n = 19) 5/19 (26.3%) 2/19 (10.5%) – Stage III (n = 22) 9/22 (40.9%) 4/22 (18.2%) 2/22 (9%) Stage IV (n = 7) 6/7 (85.7%) 1/7 (14.3%) 2/7 (28.6%) Stage V (n = 5) 3/5 (60%) 2/5 (40%) 1/5 (20%) CKD = chronic kidney disease; iFGF-23 = intact fibroblast growth factor 23; PTH = parathyroid hormone; 25-OH-vitD = 25-OH-vitamin D. Specifically, 20% of stage I, 26.3% of stage II, 40.9% of stage III, 85.7% of stage IV, and 60% of stage V CKD patients had iFGF-23 levels above the cutoff. In addition, insufficient 25-OH-vitD values were found in 9%, 28.6%, and 20% of patients at CKD stages III, IV, and V, respectively. Table II shows the percentages of patients with increased serum values of iFGF-23,1-84 PTH, and 25-OH-vitD deficiency divided according to the number of years since transplanta- tion (<10 years, 11-20 years, and >20 years). keywords: ckd; fgf-23; patients; pth; stage; vitd; years cache: jcb-2328.pdf plain text: jcb-2328.txt item: #72 of 80 id: jcb-2329 author: Balis, Frank M.; Lester McCully, Cynthia; Busch, Christine M.; Fox, Elizabeth; Warren, Katherine E. title: Pharmacokinetics of the disialoganglioside, GD2, a circulating tumor biomarker for neuroblastoma, in nonhuman primates date: 2021-12-03 words: 2724 flesch: 52 summary: The limited volume of distribution, which is equivalent to plasma volume in NHPs, enhances sensitivity because the G D2 is concentrated in (limited to) the compartment from which it is being measured. Binding of G D2 to LDL and, to a lesser extent, other lipoproteins accounts for the volume of distribution being limited to plasma volume, and likely also accounts for the lack of G D2 penetration into the CSF in the NHP CSF access model. keywords: biomarker; concentration; csf; plasma; tumor; volume cache: jcb-2329.pdf plain text: jcb-2329.txt item: #73 of 80 id: jcb-2337 author: Sullivan, Frank M.; Tello, Agnes; Rauchhaus, Petra; Hernandez Santiago, Virginia ; Daly, Fergus title: Assessment of background levels of autoantibodies as a prognostic marker for severe SARS-CoV-2 infection date: 2022-05-03 words: 2987 flesch: 57 summary: Extremely high levels of proinflammatory cytokines can lead to a cytokine storm and macrophage activation https://doi.org/10.33393/jcb.2022.2337 https://creativecommons.org/licenses/by-nc/4.0/legalcode mailto:fms20@st-andrews.ac.uk Sullivan et al. Jamal M, Bangash HI, Habiba M, et al. keywords: cancer; covid-19; crossref; earlycdt; lung; pubmed; sars; test cache: jcb-2337.pdf plain text: jcb-2337.txt item: #74 of 80 id: jcb-2356 author: Sodagar, Hadi; Alipour, Shahriar; Hasani, Sepideh ; Gholizadeh-Ghaleh Aziz, Shiva ; Khadem Ansari, Mohammad Hasan ; Asghari, Rahim title: The role of microRNAs in COVID-19 with a focus on miR-200c date: 2022-03-21 words: 7797 flesch: 55 summary: Tumor-suppressive microRNA- 449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells. Tambyah PA, Sepramaniam S, Ali JM, et al. microRNAs in circu- lation are altered in response to influenza A virus infection in humans. keywords: ace2; angiotensin; biol; cancer; cells; covid-19; crossref; disease; et al; expression; fibrosis; gene; human; infection; lung; micrornas; mir-200c; mirnas; pubmed; receptor; replication; role; sars; target; virus cache: jcb-2356.pdf plain text: jcb-2356.txt item: #75 of 80 id: jcb-2370 author: Luz Pessuti, Carmen; Fialho Costa, Deise ; Ribeiro, Kleber S. ; Abdouh, Mohamed ; Tsering, Thupten; Nascimento, Heloisa ; Commodaro, Alessandra G. ; Affonso Antunes Marcos, Allexya ; Torrecilhas, Ana Claudia ; Belfort, Rubens N. ; Belfort Jr, Rubens ; Valdemarin Burnier, Julia title: Characterization of extracellular vesicles isolated from different liquid biopsies of uveal melanoma patients date: 2022-06-27 words: 8231 flesch: 57 summary: N Y N Tsukushin TSK N Y N Beta-crystallin A3 CRBA1 N N Y Beta-crystallin A4 CRBA4 N N Y Gamma-crystallin C CRGC N N Y Gamma-crystallin D CRGD N N Y Gamma-crystallin B CRGB N N Y Beta-crystallin B3 CRBB3 N N Y Filensin BFSP1 N N Y Protein S100-B S100B N N Y Secreted frizzled-related protein 3 SFRP3 N N Y Phakinin BFSP2 N N Y DNA polymerase theta DPOLQ Journal of Circulating Biomarkers - ISSN 1849-4544 - www.aboutscience.eu/jcb TABLE III - Newly characterized protein from EVs isolated from plasma, aqueous humor, or vitreous humor Identified Proteins ID P VH AH Complement C4-B CO4B Y Y Y Beta-crystallin B1 CRBB1 Y Y Y Vitamin K-dependent protein C PROC Y Y N Immunoglobulin J chain IGJ Y Y N L-selectin LYAM1 Y Y N Neuropilin-2 NRP2 Y Y N Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D SRCRL Y N N Extracellular matrix protein 2 ECM2 Y N N Plexin domain-containing protein 1 PLDX1 Y N N Retinol-binding protein 3 RET3 N Y Y Opticin OPT N Y Y Beta-1,4-glucuronyltransferase 1 B4GA1 N Y Y Wnt inhibitory factor 1 WIF1 N Y Y Beta-Ala-His dipeptidase CNDP1 N Y N Receptor-type tyrosine-protein phosphatase zeta PTPRZ keywords: analysis; cancer; cell; crossref; et al; evs; exosomes; extracellular; fig; humor; melanoma; n n; n y; patients; plasma; protein; pubmed; samples; uveal; vesicles cache: jcb-2370.pdf plain text: jcb-2370.txt item: #76 of 80 id: jcb-2386 author: Erfurt, Stefan; Hoffmeister, Meike; Oess, Stefanie; Asmus, Katharina; Patschan, Susann; Ritter, Oliver; Patschan, Daniel title: Soluble IL-33 receptor predicts survival in acute kidney injury date: 2022-06-06 words: 5550 flesch: 58 summary: Akcay A, Nguyen Q, He Z, et al. IL-33 exacerbates acute kidney injury. Hoste EAJ, Kellum JA, Selby NM, et al. keywords: acute; aki; brandenburg; crossref; hospital; injury; kidney; patients; pubmed; recovery; serum; sst2; study; subjects cache: jcb-2386.pdf plain text: jcb-2386.txt item: #77 of 80 id: jcb-2446 author: Hasan, Diya title: Diagnostic impact of CEA and CA 15-3 on monitoring chemotherapy of breast cancer patients: Chemotherapy monitoring by serum markers date: 2022-11-07 words: 5024 flesch: 59 summary: Diagnostic impact of CEA and CA 15-3 on chemotherapy monitoring of breast cancer patients Diya Hasan Department of Allied Medical Sciences, Zarqa College, Al-Balqa Applied University, Zarqa - Jordan ABSTRACT Introduction: Serum tumor markers have emerged as an effective tool to determine prognosis and treatment efficiency in different cancer types. Results: CA 15-3 had a higher elevation than CEA in the pretreatment group of breast cancer patients when compared to healthy controls. keywords: breast; cancer; cea; chemotherapy; crossref; levels; markers; patients; pubmed; serum; stage; treatment cache: jcb-2446.pdf plain text: jcb-2446.txt item: #78 of 80 id: jcb-2453 author: Suttichaimongkol, Tanita; Mitpracha, Manoon; Tangvoraphonkchai, Kawin; Sadeea, Phuangphaka; Sawanyawisuth, Kittisak; Sukeepaisarnjaroen, Wattana title: PIVKA-II or AFP has better diagnostic properties for hepatocellular carcinoma diagnosis in high-risk patients date: 2023-02-17 words: 4498 flesch: 61 summary: Xu F, Zhang L, He W, Song D, Ji X, Shao J. The diagnostic value of serum PIVKA-II alone or in combination with AFP in Chinese hepatocellular carcinoma patients. Two biomarkers were used for HCC diagnosis including alpha-fetoprotein (AFP) and protein induced by vitamin K absence-II or antagonist (PIVKA-II). keywords: afp; carcinoma; crossref; hcc; hepatocellular; patients; pivka; pubmed; study cache: jcb-2453.pdf plain text: jcb-2453.txt item: #79 of 80 id: jcb-2479 author: Khan, Mosin Saleem; Rashid, Tabassum; Altaf, Syed Sadaf; Rasool, Shabhat; Iliyas, Rabiya; Rashid, Sabia; Majid, Sabhiya title: Impact of clinico-biochemical variations on the etiopathogenesis of cataract: a case-control study date: 2023-01-16 words: 7771 flesch: 58 summary: Results Table I contains the socio-demographic and clinicopatho- logical characteristics of cataract cases and healthy controls. The history of any other eye disorder was present in 23.0% (69 of 300) of cataract cases. keywords: age; blood; calcium; cases; cataract; controls; crossref; eye; levels; parameters; patients; potassium; pubmed; serum; sodium; study cache: jcb-2479.pdf plain text: jcb-2479.txt item: #80 of 80 id: jcb-2502 author: Tjerkstra, Maud; Labib, Homeyra; Coert, Bert A.; Spijker, René; Coutinho, Jonathan M.; Vandertop, W. Peter; Verbaan, Dagmar title: Laboratory biomarkers of delayed cerebral ischemia following subarachnoid hemorrhage: A systematic review date: 2023-04-05 words: 7159 flesch: 48 summary: TABLE I - Criteria of the clinical and radiological definition of DCI Clinical DCI Defined as: • �A� decrease� in� level� of� consciousness� (described� by� a� decrease� of�the�Glasgow�Coma�Scale�score�or�an�increase�of�the�National� Institutes�of�Health�Stroke�Scale�score)�or • �Focal�neurological�impairment�(e.g.,�aphasia,�motor�impairment,� sensory�deficits,�neglect)� Excluded if: • �Vague�definitions�of�DCI,�e.g.,�“clinical�deterioration,”�“neurological� deterioration,”� “worsening� of� neurological� condition,”� without� specifically�mentioning�either�decreased�level�of�consciousness� or focal neurological impairment • �The�DCI�cohort�also�includes�patients�with�solely�signs�of�vasospasm� without�clinical�symptoms�of�DCI.�For�example,�patients�with:�  •  � Coagulation�cascade 33 15 All�indicated�increased�platelet�activity,�hypercoagulability,�or� hyperfibrinolysis.�No�specific�trend�in�time. keywords: biomarkers; cerebral; crossref; dci; hemorrhage; patients; quality; review; sah; studies; study; subarachnoid cache: jcb-2502.pdf plain text: jcb-2502.txt