Type of Article: Letter to the Editor Title: Can the microbiome affect human reproductive function? Authors: Mohammad Akhoondian a, Shervin Yavari b, Moslem Karampoor c, Amin Fouladpour d, Alireza Samadnia e, Samad Karkhah f* Affiliations: a. Department of Physiology, School of Medicine, Cellular and the Molecular Research Center, Guilan University of Medical Science, Rasht, Iran. b. Department of Parasitology, School of Medicine, Guilan University of Medical Science, Rasht, Iran. c. Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. d. Department of Orthopedics, Poorsina Hospital, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. e. Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. f. Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran. *Corresponding Author: Samad Karkhah (MSc) Address: Nursing and Midwifery School of Shahid Dr Beheshti, Hamidyan Shahrak, Shahid Dr Beheshti Ave., Rasht, Guilan, IRAN Fax: +98-13-33550097; Postal code: 41469-39841 Tel: +98-9032598167; +98-13-33552088; Email: sami.karkhah@yahoo.com Emails and Degree: Samad Karkhah (MSc), Email: sami.karkhah@yahoo.com (ORCID: 0000-0001-9193-9176). Short Title: Can the microbiome affect human reproductive function? Number of Tables: 0 Number of Figures: 0 Words Count: Main Text: 497.