J Islamabad Med Dental Coll 2020 6 Open Access Accuracy of Multi-Detector Computed Tomography in Detection of Esophageal Varices in Chronic Liver Disease Syeda Zakia Shah1, Umair Ajmal2, Shahabuddin Siddiqui2 1Assistant Professor, Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad 2Post Graduate Resident, Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad A B S T R A C T Background: Patients with chronic liver disease should undergo screening endoscopy, but this approach places a heavy burden upon endoscopy units along with other limitations. The aim of this study was to determine the diagnostic accuracy of multi-detector computed tomography scan in detecting esophageal varices taking endoscopy as gold standard. Material and Methods: This cross-sectional study was done from 1 st Jan 2018 to 31st Dec 2018 at Department of Radiology, PIMS Hospital Islamabad. A total of 180 patients of both gender with chronic liver disease for at least 12 months were included in this study with an age range of 25-65 years. Patients with active gastrointestinal hemorrhage, hypersensitivity to iodinated contrast agent, chronic renal failure, claustrophobic and pregnant females were excluded. All the patients underwent endoscopy and computed tomography of lower chest and the upper abdomen before and after intravenous contrast administration. Multi detector computed tomography (MDCT) scan findings for esophageal varices were compared with endoscopy findings. Results: In MDCT positive patients (n=102), 98 were true positive and 04 were false positive. Among 78 MDCT negative patients, 07 were false negative, whereas 71 were true negative. Overall sensitivity and specificity were 93.33%, and 94.67% respectively. The positive and negative predictive values were 96.08% and 91.03% respectively, while diagnostic accuracy of MDCT in detecting esophageal varices in chronic liver disease patients was 93.89%, taking endoscopy as gold standard. Conclusions: Multi-detector computed tomography scan is a highly sensitive and accurate non -invasive modality for detecting esophageal varices in chronic liver disease patients. Key words: Accuracy, Chronic liver disease , Esophageal varices, Multi-de tec tor computed tomograph y Authors’ Contribution: 1-3Conception; Literature research; manuscript design and drafting; Critical analysis and manuscript review; Data analysis; Manuscript Editing. Correspondence: Syeda Zakia Shah Email: sphoolsh@gmail.com Article info: Received: May 29, 2019 Accepted: February 20, 2020 Cite this article. Shah SZ, Ajmal U, Siddiqui S. Accuracy of Multi-Detector Computed Tomography in Detection of Esophageal Varices in Chronic Liver Disease . J Islamabad Med Dental Coll.2020; 9(1): 6-11. Doi: 10.35787/jimdc.v9i1.346 Funding Source: Nil Conflict of Interest: Nil I n t r o d u c t i o n Portal hypertension is a serious complication of cirrhosis. It is defined as a hepatic venous pressure gradient (HVPG) above 5 mm Hg. Development of significant complication of portal hypertension i.e. ascites and esophageal and gastric varices results when HVPG increase s above 10 mmHg.1 Commonest lethal complication of portal hypertension is variceal bleeding. Gastroesophageal varices are the most common porto-systemic collaterals and their rupture OR I GI N A L A R TI C LE J Islamabad Med Dental Coll 2020 7 results in dangerous variceal bleeding. 2 The gold standard for identifying the presence and size of varices is esophagogastroduodenoscopy (EGD). Current guidelines recommend EGD to be performed in all patients with cirrhosis at the time of diagnosis and subsequently every 1-2 years, depending on the findings of the first examination and on the severity of cirrhosis.3 EGD has high sensitivity and specificity for the presence and grade of varices due to its ability to insufflate air and perform retroflexion in the gastric cardia and fundus. Disadvantages include the need for intravenous sedation, relatively high cost and complications related to its invasive nature. 4 Many non-invasive or minimally invasive methods have been proposed as alternatives to EGD for screenin g of varices. The most promising ones are the platelet count (PLT) to spleen diameter ratio, transient elastography, computed tomography (CT), and video capsule endoscopy.5,6 In a study carried out on liver cirrhosis patients, esophageal varices were found in 63.16% patients and MDCT was accurate in detecting esophageal varices with a sensitivity o f 86.1% and specificity of 57.1%.7 CT is a non-invasive imaging modality and can be used routinely in general practice for detecting esophageal varices and for selection of timely and proper treatment option in order to reduce the morbidity and mortality of these patients. Since there was controversy in the available literature o n diagnostic accuracy of computed tomography scan in detecting esophageal varices,5 so this study was conducted to determine the diagnostic accuracy of MDCT in our set up, taking endoscopy as gold standard. M a t e r i a l a n d M e t h o d s This cross-sectional study was done from 1st January 2018 to 31st December 2018 at Department of Radiology, PIMS Hospital Islamabad after approval from institutional ethical committee was taken. A total of 180 patients of both gender with chronic liver disease for at least 12 months were included in this study with an age range of 25-65 years. Patients with active gastrointestinal hemorrhage, hypersensitivity to iodinated contras t agent, chronic renal failure, claustrophobic and pregnant females were excluded. Sample size was calculated by using sensitivity and specificity calculator (Mohd. Ayub Sadiq, School of Dental Sciences, Univerasiti Sains Malaysia), by taking 95% confidence level with expected prevalence of esophageal varices as 63.16%,5 12% desired precision for sensitivity of 86.1% and 12% for specificity of 57.1% of MDCT scan in detecting esophageal varices.7 After taking informed consent, computed tomography of lower chest and the upper abdomen was performed after intravenous contrast administration on Multislice MDCT scanner (Aquilion Toshiba). Three sets of images were acquired in a craniocaudal direction at 25, 65, and 180s after injection of the contrast medium. The first acquisition was used for hepatic arterial phase imaging, the second for portal venous phase imaging, and the 3rd acquisition to image the hepatic venous phase. Images were obtained during single breath holding. Each MDCT scan were looked for esophageal varices by an experienced consultant radiologist (experience o f at least 5 years). Esophageal varices were considered to be present when enhancing vascular structures within the wall of the esophagus projected into the lumen measuring ≥5 mm. All patients then underwent endoscopy in the gastroenterology department of PIMS by the same consultant. Cherry red and dark red spots on the mucosa of the lower esophagus on endoscopy was taken as positive for esophageal varices. MDCT scan findings were compared with endoscopy findings. All this data including the demographic data was recorded on a pre -design e d J Islamabad Med Dental Coll 2020 8 proforma and analyzed through computer software SPSS version 20.0. Mean and standard deviation were calculated for quantitative variables i.e. age. Frequency and percentage were calculated for qualitative variables i.e. gender and esophageal varices on MDCT scan and endoscopy. A 2×2 contingency table was used to calculate sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of MDCT scan in detecting esophageal varices, taking endoscopy as gold standard. R e s u l t s Patients included in the study had a mean age of 47.57 ± 10.56 years and an age range from 25-65 years. Majority of the patients (52.78%) were between 46- 65 years of age. Regarding gender distribution, 100 (55.56%) were males and 80 (44.44%) were females with a male -to- female ratio of 1.25:1. All the patients were subjected to multi- detector computed tomography scan with the diagnosis of esophageal varices in 102 (56.67%) patients and no esophageal varices in 78 (43.33%) patients (Figure 1). Endoscopy findings confirmed esophageal varices in 105 (58.33%) patients and no esophageal varices in 75 (41 .67%) patients. In MDCT positive patients, 98 (True Positive) had esophageal varices and 04 (False Positive) had no esophageal varices on endoscopy. Among 78 MDCT negative patients, 07 (False Negative) had esophageal varices whereas 71 (True Negative) had no esophageal varices on endoscopy (Table I). Overall, there was a high sensitivity (93.33%), specificity (94.67%), positive predictive value (96.08%), negative predictive value (91.03%) and diagnostic accuracy (93.89%) of multi- detector computed tomography scan in detecting esophageal varices in chronic liver disease patients, taking endoscopy as gold standard (Figure 2). Table I: Sensitivity and specificity of multi-detector computed tomography scan and endoscopy in detecting esophageal varices. Result on endoscopy (n) Total Positive Negative Patients with positive result on MDCT 98 (TP) 04 (FP) 102 Patients with negative result on MDCT 07 (FN) 71 (TN) 78 Total 105 75 180 TP-True Positive; FP-False Positive; TN- True Negative; FN- False Negative Figure 1: Appearance of esophageal varices on CT. Arrow points to enhancing vascular structures within the wall of the esophagus projecting into the lumen Figure 2: Diagnostic Accuracy of MDCT Scan in Percentages PPV-Positive predictive value; NPV-Negative predictive value J Islamabad Med Dental Coll 2020 9 D i s c u s s i o n Early diagnosis of gastroesophageal varices before the onset of first bleed is highly recommended as many studies showed that the risk of variceal bleeding can be reduced from 50% to 15% for large esophageal varices.8 Esophagogastroduodenoscopy (EGD) is the gold standard in the diagnosis of gastroesophageal varices. However, due to its invasiveness, expense, need for sedation, and patient’s poor acceptance of the procedure, the use of endoscopy as a method of screening is limited.9,10 We conducted this study to determine the diagnostic accuracy of multi -detector computed tomography scan in detecting esophageal varices in chronic liver disease patients, taking endoscopy as gold standard. In our study the overall sensitivity and specificity of computed tomography scan in detecting esophageal varices in chronic liver disease patients, taking endoscopy as gold standard was 93.33% and 94.67% respectively. In a study performed by Kammash et al, the overall sensitivity and specificity of MDCT to detect esophageal varices were 99.40% and 99.60% respectively.11 The sensitivity and specificity of triphasic CT enterography with ingestion of neutral oral contrast material were 42% and 100% respectively in the detection of acute GI bleeding in a recent study by Hara et al.12 In a study by Scheffel et al, multidetector CT with arterial and portal phases of contrast enhancement and with no oral contrast material was able to show the bleeding source prospectively in 83% of patients.13 CT can be a good alternative for the detection of varices in cirrhotic patients with HCC, already undergoing local regional treatments. The effectiveness of the treatment and the presence of recurrence are evaluated by CT in these patients and Kim et al14 showed high sensitivity (91.9%) and specificity (92.2%) for the detection of esophageal varices without alteration of the CT protocol. The efficacy of standard thick-slice CT, especially for the detection of large varices, was demonstrated by two studies,15,16 without thin slice reconstruction adding accuracy. In addition, like ultrasonography, CT is also an operator-dependent method, but radiologist residents and endoscopists showed similar performance to specialized abdominal radiologists in the detection of large varices. Abdominal radiologists were more efficient in the detection of small varices compared to residents and endoscopists.17 CT scan is an excellent method for detecting moderate to large esophageal varices and for evaluating the entire portal venous system. It is a minimally invasive imaging modality that involves the use of only a peripheral intravenous line; therefore, it is a more attractive method than angiography or endoscopy in the evaluation of the portal venous system. In the only study directly comparing CT with the platelet/spleen diameter ratio, CT proved to have higher sensitivity and specificity.7 This method is better tolerated than endoscopy and more readily accepted by patients even in studies where air insufflation was used before performing CT.18 Moreover, CT can be simultaneously used as a screening method for HCC and varices in cirrhotic patients. The main disadvantage of CT is the radiation dose, although, considering the high mean age of cirrhotic patients, the benefits are likely to outweigh the risk of radiation-induced carcinogenesis.19 The cost of the method is high e r compared to other non-invasive methods, but lower compared to endoscopy.20 Several studies have compared CT and endoscop y findings. A cut off point of 5 mm was previously shown to have approximately 90% sensitivity and 50% specificity for large varices.21, Another study J Islamabad Med Dental Coll 2020 10 used a 3-mm threshold for varices on CT to accurately predict the presence of large varices on EGD.22 According to Deng and his colleagues, the sensitivity and specificity of Contrast Enhanced CT (CECT) scan were 95.56% and 71.43%, respectively. They concluded that CECT scans have a moderate diagnostic accuracy for esophageal varices in liver cirrhosis. CECT scan might be useful to decrease the use of upper gastrointestinal endoscopy in clinical practice.23 CT is an imaging modality that is quite precise in visualization of esophageal varices. CT could detect early HCC and hence is useful in the holistic management of cirrhotics. It is of paramount importance to underline the diagnostic value of CT in early detection of varices. Radiologists should comment on incidental findings of varices even when it is done for other reasons. Limitation: Intravenous contrast is required for diagnosis of esophageal varices, which may be contraindicated in patients with impaired renal function or allergy to iodine. C o n c l u s i o n This study concluded that multi-detector computed tomography scan is a highly sensitive and accurate non-invasive modality in detecting esophageal varices in chronic liver disease patients. It has not only dramatically improved our ability to accurately diagnose esophageal varices but also contributed to patients’ care with timely and proper treatment. Endoscopy might be reserved mainly for therapeutic purposes. Although this appeared unrealistic a few years ago, advances in technology and more prospective studies could make it feasible in the future. R e c o m m e n d a t i o n s We recommend that multi-detector computed tomography (MDCT) should be used routinely as a prime modality for detecting esophageal varices in chronic liver disease patients and in patients not willing for endoscopy. It will result in proper and timely management and will reduce the morbidity and mortality of these patients. CT can be a good alternative for the detection of varices in cirrhotic patients with HCC, already undergoing loco regional treatments. The effectiveness of the treatment and the presence o f recurrence is evaluated by CT in these patients. R e f e r e n c e s 1. Salzl P, Reiberger T, Fe rlitsch M, Payer BA, Schwengerer B, Trauner M. et al. Evaluation of portal hypertension and varices by acoustic radiation force impulse imaging of the liver compared to transient elastography and AST to platelet ratio index. Ultraschall Med. 2014; 35(6): 528-33. Doi: 10.1055/s-0034-1366506 2. Masalaite L, Valantinas J, Stanaitis J. 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