id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
jnps-41521	Kumar, Arvind; Arora, Harmeet Singh; Marwah, Vikas; Mishra, Satish Chandra; Ravi, Akhil K ; Kalra, Dinesh Kumar; Shaw, Subhash Chandra	Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Characteristics and Cycle Threshold Value (CT value) of Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) of Nasopharyngeal Samples	2022-12-31	5	.pdf	application/pdf	3578	252	63	The correlation between CT values of RT-PCR test and viral cell culture was found significant in a study in France.19 Similarly, another study from Canada showed there was significant correlation between CT values and infectivity in cell culture; and concluded that infectivity of patients may be low who has CT value <24.20 However, a study from US showed positive culture growth from samples with CT values of 34.21 Later, systematic review from Stanford University analyzed this study and revealed that study population (elderly patients in elder care facility) of this study might not represent the general population.22 Recently, authors of another systematic review including 17 studies on viral load (CT values) and symptom severity, concluded that infectivity decreases after a week of viral shedding and cycle threshold value of 24.23 In our study, we did not find any significant difference in CT values of paediatric and adolescence age groups. However, younger children (< 5 years of age ) had significant lower CT values than adults.24 In another study from Switzerland, authors compared viral load values of 53 children with values of 352 adults and found no significant difference.25 Similarly, a study of 201 children from Greece reported no difference in viral load of paediatric and adolescence age groups, neither any difference of viral loads between symptomatic and asymptomatic children.26 However, another study from US comprising of 339 asymptomatic and 478 symptomatic children found significantly higher CT values of asymptomatic children than symptomatic children of	cache/jnps-41521.pdf	txt/jnps-41521.txt
