item: #1 of 23
          id: jrenhep-10
      author: Salvadori, Maurizio; Tsalouchos, Aris
       title: Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease
        date: 2017-03-15
       words: 12603
      flesch: 50
     summary: Yamaguchi T, Pelling JC, Ramaswamy NT, Eppler JW, Wallace DP, Nagao S, et al. cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal regu- lated kinase pathway. Nagao et al.
    keywords: adpkd; autosomal; camp; cell; cyst; cystic; cystogenesis; dominant; effects; et al; function; group; growth; kidney; kidney disease; liver; model; mtor; nephrol; patients; pkd1; placebo; progression; proliferation; receptor; renal; signaling; sirolimus; soc; study; tkv; tolvaptan; treatment; trial; vasopressin
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        item: #2 of 23
          id: jrenhep-104
      author: Latief, Muzamil; Bhat, Mohd Iqbal; Wani, Mohd Latief; Shafi, Obeid; Goud, L. Naresh; Abbas, Farhat; Wani, Mohsin
       title: Gabapentin Toxicity and Role of Dialysis; Case Series and Literature Review
        date: 2021-12-14
       words: 2002
      flesch: 58
     summary: Most of the published literature on gabapentin toxicity in CKD are case studies (3,4). In cases reported with gabapentin toxicity, patients had varying manifestations including tremors, altered mental status, and respiratory depression requiring intubation (5).
    keywords: case; dialysis; gabapentin; kidney; patient; toxicity
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        item: #3 of 23
          id: jrenhep-11
      author: Coppolino, Giuseppe; Cernaro, Valeria; Rivoli, Laura; Pinciaroli, Angela; Bolignano, Davide
       title: Renal Concerns in the Treatment of Chronic Hepatitis B with Tenofovir
        date: 2017-03-23
       words: 4304
      flesch: 44
     summary: Screening of risk factors for renal disease before starting TDF therapy and a careful mon- itoring of sCr, eGFR, serum phosphate and urine analysis during treatment are important mainstays for guiding the pre- scription of this drug and to promptly reduce dosage or inter- rupt therapy if nephrotoxicity occurs. Dose adjustment of TDF and early diagnosis of TDF-related renal damage The American Association for the Study of Liver Diseases (AASLD) guidelines recommend to measure eGFR, phospha- turia, urine protein/creatinine ratio, glycosuria and tubular proteinuria in patients with HIV infection every 6 months during TDF therapy.
    keywords: chronic; disease; drug; function; hbv; hepatitis; hiv; kidney; patients; renal; study; tdf; tenofovir; therapy
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        item: #4 of 23
          id: jrenhep-12
      author: Chan, Samuel; Au, Kenneth; Francis, Ross; Mudge, David W.; Johnson, David W.; Rahman, Tony
       title: An Update on Hepatorenal Syndrome
        date: 2017-03-22
       words: 3893
      flesch: 43
     summary: Simultaneous liver–kidney transplantation is not necessary for patients with isolated HRS and should only be considered in selected patients at high risk for non-recov- ery of renal function, such as patients with heavy proteinuria and other evidence of advanced primary renal disease. JRENHEP012 - Copy 55..61 jrenhep.com codonpublications.com REVIEW ARTICLE An Update on Hepatorenal Syndrome Samuel Chan 1,2 , Kenneth Au 2,3 , Ross Francis 1 , David W. Mudge 1 , David W. Johnson 1 , Tony Rahman 3 1Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia; 2Centre for Health Services Research, University of Queensland, Brisbane, Queensland, Australia; 3Department of Gastroenterology and Hepatology, The Prince Charles Hospital, Chermside, Queensland, Australia Abstract Hepatorenal syndrome (HRS) is one of the many potential causes of acute kidney injury (AKI) in patients with decompensated liver disease.
    keywords: aki; cirrhosis; hepatorenal; hrs; kidney; liver; patients; syndrome; transplantation
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        item: #5 of 23
          id: jrenhep-15
      author: Rech, Megan A.; Von Roenn, Natasha; Durazo-Arvizu, Ramon; Cotler, Scott J.; Kramer, Holly
       title: Vitamin D Levels Are Associated with Liver Disease Severityin Patients with Cirrhosis
        date: 2017-05-26
       words: 5038
      flesch: 52
     summary: Rech MA et al. Journal of Renal and Hepatic Disorders 2017; 1(2): 1–9 4 were selected because they may influence vitamin D levels (2, 6). A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations.
    keywords: 25(oh)d; albumin; calcium; cirrhosis; disease; levels; liver; meld; patients; serum; vitamin
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        item: #6 of 23
          id: jrenhep-17
      author: Kinaan, Mustafa; Yau, Hanford; Martinez, Suzanne Quinn; Kar, Pran
       title: Concepts in Diabetic Nephropathy: From Pathophysiologyto Treatment
        date: 2017-06-30
       words: 12424
      flesch: 44
     summary: Diabetic patients are predisposed to hyperlactemia with lac- tate levels being double than those in healthy individuals. Direct renin inhibitors like aliskiren can lower blood pres- sure and albuminuria in diabetic patients.
    keywords: albuminuria; blood; ckd; complications; control; diabetes; diabetic; disease; dkd; effect; et al; glucose; group; hba1c; inhibitors; insulin; kidney; levels; med; microalbuminuria; nephropathy; outcomes; patients; progression; renal; risk; role; studies; study; therapy; treatment; trial; type
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        item: #7 of 23
          id: jrenhep-18
      author: Salvadori, Maurizio; Tsalouchos, Aris
       title: Liver Transplantation for Monogenic Metabolic Diseases Involvingthe Kidney
        date: 2017-07-19
       words: 8797
      flesch: 51
     summary: Liver or combined liver-kidney transplantation Journal of Renal and Hepatic Disorders 2017; 1(2): 29–40 35 Alpha1-antitrypsin deficiency The most common genetic cause of liver disease in children is AATD (102), an autosomal recessive disorder caused by mutations in the SERPINA 1 gene (103). Liver disease develops in children with PiZZ mutation.
    keywords: children; clkt; combined; deficiency; disease; disorders; et al; failure; gene; glycogen; hepatic; hyperoxaluria; kidney; liver; liver transplantation; lta; monogenic; mutations; normal; patients; pediatr; primary; renal; storage; therapy; transplantation; treatment; type; tyrosinemia
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        item: #8 of 23
          id: jrenhep-2
      author: Pothugunta, Krishna; Voora, Santhi; Kramer, Holly Joy; Bidani, Anil K.; Vellanki, Kavitha
       title: Outcomes of Albumin Use in the Treatment of Acute Hepatorenal Disorders: A Single Center Experience
        date: 2017-02-03
       words: 3756
      flesch: 48
     summary: Earlier studies have reported cases of increasing pleural effusions, development of pulmonary edema, and heart failure and rupture of esopha- geal varices with albumin infusions in cirrhotic patients (12). A lag period between albumin infusions and CXR findings and/or symptoms of pulmonary edema could be a major confounder when trying to determine a cor- relation between the amount of albumin infused and the development of pulmonary edema.
    keywords: albumin; cirrhosis; edema; infusions; oliguria; patients; recovery; serum; volume
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        item: #9 of 23
          id: jrenhep-20
      author: Card, Mary Elizabeth; Moeckel, Gilbert; Turner, Jeffrey M.
       title: Renal Recovery Following Orthotopic Liver Transplant after Prolonged Kidney Injury: Perspectives on Diagnosing Hepatorenal Syndrome and Determining Which Patients Should Undergo Simultaneous Liver–Kidney Transplantation
        date: 2017-07-20
       words: 3293
      flesch: 48
     summary: 2. Johnson R, Couser W. Hepatitis B infection and renal disease: Clinical, immunopathogenic and therapeutic considerations. Kidney Int. Our understanding of why some patients with HRS recover renal function after OLT and why others do not is limited; however, some data suggest that duration of kidney injury prior to transplant is an important factor (5).
    keywords: cirrhosis; disease; hrs; injury; kidney; liver; olt; patients; renal; slk; transplant
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        item: #10 of 23
          id: jrenhep-3
      author: Campos, Andreia; Santos, Josefina; Freitas, Cristina; Castro, Ana; Santos, Sofia; Pedro Pimentel, Joa ̃o; Cabrita, Antonio
       title: Plasmapheresis in the Management of Acute Pancreatitis due to Severe Hypertriglyceridemia—Reporting New Cases
        date: 2017-02-03
       words: 4297
      flesch: 53
     summary: PF was done according to TG levels. It is generally believed that TG levels of >1000 mg/dl are a greater risk factor for AP (3).
    keywords: acute; case; hypertriglyceridemia; pancreatitis; patients; plasmapheresis; severe; treatment
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        item: #11 of 23
          id: jrenhep-33
      author: Lioufas, Nicole; Street, Alan; de Crespigny, Paul Champion; G. Holt, Stephen
       title: Monitoring the Effects of Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide Switch for Tubulotoxicity in Highly Treatment-Experienced or in Very Sick Individuals Infected with HIV
        date: 2018-06-29
       words: 3359
      flesch: 48
     summary: Utility of uAPR measurement in HIV infection. HIV infection: Epidemi- ology, pathogenesis, treatment, and prevention.
    keywords: creatinine; hiv; mmol; patients; proteinuria; taf; tdf; tenofovir
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        item: #12 of 23
          id: jrenhep-34
      author: Agrawal, Nikhil; Agrawal, Sahil; Tripathi, Nishita; Segal, Mark
       title: Potassium Profiling in Hemodialysis
        date: 2018-08-07
       words: 2628
      flesch: 50
     summary: We provide a review of studies that compare constant potassium concentration in dialysate to gradual reduction in dialysate potassium concentration. In a large international cohort of HD patients, dialysate potassium concentration varied among clinical practices and countries and ranged anywhere from 1 meq/L to 3 meq/L (28).
    keywords: cardiac; concentration; dialysate; dialysis; hemodialysis; patients; potassium; profiling; serum
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        item: #13 of 23
          id: jrenhep-37
      author: Greco, Federico; Augusto Mallio, Carlo; Cirimele, Vincenzo; D’Alessio, Pasquale; Beomonte Zobel, Bruno; Francesco Grasso, Rosario
       title: Imaging of Renal Angiomyolipomatosis
        date: 2018-11-14
       words: 6522
      flesch: 51
     summary: Update on the diagnosis and management of renal angiomyolipoma. Changing trends in presentation, diagnosis and management of renal angiomyolipoma: Comparison of sporadic and tuberous sclerosis complex-associated forms.
    keywords: aml; amls; angiomyolipoma; angiomyolipomatosis; carcinoma; cell; diagnosis; epithelioid; et al; fat; features; https://doi; imaging; kidney; lesion; patients; renal; sclerosis; tissue; tuberous; tumor
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        item: #14 of 23
          id: jrenhep-43
      author: Salvadori, Maurizio; Tsalouchos, Aris
       title: Hepatitis C Virus Infection and Renal Disorders
        date: 2019-01-16
       words: 10185
      flesch: 49
     summary: Both recurrent and de novo GN have been observed in HCV renal transplant patients. Overall, the prevalence of MPGN is higher in HCV patients with MCs.
    keywords: c virus; chronic; ckd; combination; daa; dialysis; disease; disorders; et al; genotype; hcv; hepatitis; https://doi; infection; kidney; liver; patients; positive; renal; risk; sofosbuvir; study; transplant; transplantation; treatment; viral; virus; virus infection
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        item: #15 of 23
          id: jrenhep-47
      author: Bolik, Julia; Tirnitz-Parker, Janina E. E.; Schmidt-Arras, Dirk
       title: ADAM and ADAMTS Proteases in Hepatic Disorders
        date: 2019-02-07
       words: 7377
      flesch: 50
     summary: The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses.
    keywords: activity; adam; adam10; adamts; adamts13; cancer; catalytic; cell; disease; disintegrin; domain; et al; expression; factor; family; figure; hcc; hscs; https://doi; liver; receptor; signalling; tumour
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        item: #16 of 23
          id: jrenhep-49
      author: Mohammadzadeh, Fatemeh; Hosseini, Vahid; Alihemmati, Alireza; Shaaker, Maghsod; Mosayyebi, Gholamali; Darabi, Masoud; Mehdizadeh, Amir
       title: The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis
        date: 2019-02-06
       words: 5496
      flesch: 44
     summary: Thiazole-4-acetic acid derivative Another potent liver-selective SCD1 inhibitor, compound 48 (a thiazole-4-acetic acid derivative), has recently been discovered through high-throughput screening efforts fol- lowing an ex vivo assay approach on mice liver and eyelids (55). SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturated fatty acids into monounsaturated fatty acids.
    keywords: acid; activity; coa; desaturase; development; disorders; expression; fatty; hepatic; lipid; liver; mice; role; scd1; stearoyl; stress; tabriz; wnt
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        item: #17 of 23
          id: jrenhep-5
      author: Krishnan, Anoushka R.; Trinder, Debbie; G. Chua, Anita C.; Chakera, Aron; Ramm, Grant A.; Olynyk, John K.
       title: Anaemia of Chronic Kidney Disease: What We Know Now
        date: 2017-02-03
       words: 7260
      flesch: 46
     summary: The improvement in haemo- globin resulted from increased serum iron levels and better haemoglobinisation of erythroid precursors, without affecting inflammatory responses in these mice. Issues with iron therapy With regard to iron administration during episodes of acute infection or inflammation which results in elevated serum ferritin levels, opinions suggest that iron therapy should be withheld under such circumstances, citing a concern that iron may further help in the proliferation of microorganisms.
    keywords: anaemia; australia; blood; ckd; disease; effects; epo; erythropoiesis; et al; haemoglobin; hepcidin; hypoxia; inflammation; iron; kidney; levels; liver; metabolism; nephrol; patients; production; renal; role; serum
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        item: #18 of 23
          id: jrenhep-52
      author: Chávez-Iñiguez, Jonathan S.; Meza-Ríos, Alejandra; Santos-Garcia, Arturo; García-García, Guillermo; Armendariz-Borunda, Juan
       title: Cholemic Nephropathy: Hyperbilirubinemia and its Impact on Renal Function
        date: 2019-03-18
       words: 5201
      flesch: 46
     summary: AKI in cirrhosis patients in the context of hyperbilirubinemia AKI that occurs in patients with cirrhosis due to severe hy- poperfusion and impairment in the systemic arterial circula- tion has been known as hepatorenal syndrome (HRS) (10). Odell et al.
    keywords: aki; bile; bilirubin; cirrhosis; disorders; function; hyperbilirubinemia; kidney; levels; liver; nephropathy; patients; renal; scr
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        item: #19 of 23
          id: jrenhep-56
      author: Gonzaga, Ernesto Robalino; Andrew, Austin; Jan George, Freeman
       title: Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
        date: 2019-09-09
       words: 5609
      flesch: 48
     summary: The homeostasis of muscle bulk is tightly regulated requir- ing a balance between muscle protein synthesis and muscle proteolysis. Muscle protein synthesis and muscle satellite cell recruitment are important factors in maintaining muscle bulk.
    keywords: amino; ammonia; cirrhosis; disease; esld; et al; levels; liver; mass; mtor; muscle; myostatin; patients; protein; sarcopenia; study; synthesis
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        item: #20 of 23
          id: jrenhep-58
      author: Fradelos, Evangelos C.
       title: The Effect of Clinical and Demographic Factors on Quality of Life in End-Stage Renal Disease. A Multicenter Cross-Sectional Study
        date: 2020-05-07
       words: 5161
      flesch: 57
     summary: <0.001 Educational status Primary education (1) 3.14 ± 0.94 2.92 ± 11.65 5.68 ± 10.17 10.86 ± 13.50 High school (2) 3.59 ± 0.86 4.79 ± 8.89 6.91 ± 10.19 12.83 ± 12.29 University (3) 3.59 ± 0.94 6.71 ± 7.57 7.86 ± 12.22 13.89 ± 13.29 (Continued) Quality of life in hemodialysis Journal of Renal and Hepatic Disorders 2020; 4(1): 1–9 5 Table 1. Yes −8.86 ± 13.23 3.02 ± 13.82 16.21 ± 3.77 No −6.04 ± 13.38 6.48 ± 14.99 17.53 ± 3.83 t 1.713 1.905 2.791 p 0.087 0.058 0.006 Educational status Primary education (1) −6.74 ± 12.69 1.44 ± 14.97 16.42 ± 4.06 High school (2) −7.15 ± 14.34 8.44 ± 14.50 17.58 ± 3.62 University (3) −5.48 ± 12.50 8.32 ± 12.85 18.13 ± 3.66 (Continued) Quality of life in hemodialysis Journal of Renal and Hepatic Disorders 2020; 4(1): 1–9 7 Table 2 .
    keywords: disease; health; hemodialysis; level; life; patients; qol; quality; study
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        item: #21 of 23
          id: jrenhep-6
      author: Mehdizadeh, Amir; Darabi, Masoud
       title: Reprogrammed Cell‐based Therapy for Liver Disease: From Labto Clinic
        date: 2017-02-03
       words: 6465
      flesch: 45
     summary: Here, we introduce main practical strategies for redifferentiation of pluripotent cells to liver cells. An average 20% repopulation of liver cells was recorded.
    keywords: cells; differentiation; disease; disorders; embryonic; et al; gene; hepatocytes; human; ipscs; liver; liver cell; medicine; patient; pubmed; reprogramming; stem; stem cells; therapy; tissue; transplantation
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        item: #22 of 23
          id: jrenhep-8
      author: Testino, Gianni; Leone, Silvia
       title: Alcoholic Hepatitis and Liver Transplantation
        date: 2017-02-03
       words: 1541
      flesch: 47
     summary: Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center. Data from the literature have stated for a long time that the approach to patients with alcoholic liver disease (ALD) should be changed with no ethical or technical precon- ceptions.
    keywords: alcoholic; liver; patients; transplantation
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        item: #23 of 23
          id: jrenhep-9
      author: Halldorson, Jeffrey
       title: Welcome to the Journal of Renal and Hepatic Disorders
        date: 2017-02-03
       words: 1130
      flesch: 47
     summary: A common and well-known example of this interac- tion is the hepatorenal syndrome in end-stage cirrhosis of the liver in which the vasogenic effects of liver disease initially result in acute kidney injury but may progress to irreversible ischemic renal failure if the vasogenic influence of liver failure is not reversed quickly enough (1–3). The emerging pathophysiology of fatty liver disease is a growing topic (9).
    keywords: journal; kidney; liver; organ; renal; transplant
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