Bibliography
This is an automatically generated bibliography describing the content of this study carrel.
- cord-008837-74rfnt1x
- author: Tsang, Kenneth WT
- title: H5N1 influenza pandemic: contingency plans
- date: 2005-08-11
- words: 1045
- flesch: 39
- summary: A viruses in children treated with oseltamivir: descriptive study Avian influenza A (H5N1) in 10 patients in Vietnam New application method of zanamivir with a straw Efficacy and safety of inhaled zanamivir for the treatment of influenza in patients with asthma or chronic obstructive pulmonary disease: a double-blind, randomized, placebocontrolled multicentre study Pharmacoscintigraphic evaluation of lung deposition of inhaled zanamivir in healthy volunteers A comparison of the performance of two modern multidose dry powder asthma inhalers Are we ready for pandemic influenza? Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial.
- keywords: avian; care; children; drug; efficacy; governments; h5n1; health; influenza; inhibitors; neuraminidase; oseltamivir; outbreak; pandemic; patients; plans; rare; resistance; safety; study; treatment; vaccine; zanamivir
- versions: original; plain text
- cord-008841-r17qhfsj
- author: Tomlinson, Brian
- title: SARS: experience at Prince of Wales Hospital, Hong Kong
- date: 2003-05-03
- words: 1756
- flesch: 53
- summary: Patients presenting with other respiratory infections must now all be regarded as potential SARS cases until proven otherwise. COMMENTARY The Prince of Wales Hospital (PWH) has been at the forefront of the outbreak of severe acute respiratory syndrome (SARS) in Hong Kong.
- keywords: acute; cancer; care; cases; clinical; colorectal; coronavirus; dietary; disease; failure; fibre; health; high; hong; hospital; ill; important; infections; kong; march; outbreak; patients; people; prince; pwh; respiratory; sars; severe; spread; syndrome; wales; workers
- versions: original; plain text
- cord-008855-hahqwt5x
- author: Alwan, Ala
- title: Responding to priority health challenges in the Arab world
- date: 2014-01-20
- words: 1901
- flesch: 50
- summary: Another distinctive feature of the present health equity movement is its concern with wellbeing and not Health equity in the Arab world: the future we want The state of health in the Arab world, 1990-2010: an analysis of the burden of diseases, injuries, and risk factors Public health in the Arab world Governance and health in the Arab world Non-communicable diseases in the Arab world The path towards universal health coverage in the Arab uprising countries Tunisia Changing therapeutic geographies of the Iraqi and Syrian wars Health and ecological sustainability in the Arab world: a matter of survival Health and contemporary change in the Arab world Importance of research networks: the Reproductive Health Working Group, Arab world and Turkey State formation and underdevelopment in the Arab world Responding to priority health challenges in the Arab world Health equity in the Arab World: the future we want Research and activism for tobacco control in the Arab world The making of the Lancet Series on health in the Arab world Global action plan for the prevention and control of noncommunicable diseases Political declaration of the High-Level Meeting of the General Assembly on the Prevention and Control of Non-communicable diseases The Political Declaration of the United Nations General Assembly on the Prevention and Control of Non-Communicable Diseases: commitments of Member States and the way forward. key: cord-008855-hahqwt5x authors: Alwan, Ala title: Responding to priority health challenges in the Arab world date: 2014-01-20 journal: Lancet DOI: 10.1016/s0140-6736(13)62572-6 sha: doc_id: 8855 cord_uid: hahqwt5x nan The Arab world today faces major challenges to health development, which are captured by papers in this Series.
- keywords: action; approach; arab; assembly; burden; challenges; communicable; control; countries; coverage; declaration; development; diseases; economic; equity; global; health; high; human; justice; major; non; people; political; prevention; priority; public; region; regional; response; series; services; social; systems; tunisia; world
- versions: original; plain text
- cord-008866-be7725ap
- author: Su, Lin Lin
- title: Pregnancy and H1N1 infection
- date: 2009-10-22
- words: 687
- flesch: 44
- summary: key: cord-008866-be7725ap authors: Su, Lin Lin; Chan, Jerry; Chong, Yap Seng; Choolani, Mahesh; Biswas, Arijit; Yong, EL title: Pregnancy and H1N1 infection date: 2009-10-22 journal: Lancet DOI: 10.1016/s0140-6736(09)61854-7 sha: doc_id: 8866 cord_uid: be7725ap nan These observations suggest that antivirals ought to be used to prevent and treat H1N1 infection in highrisk pregnant women. This side-eff ect profi le, together with the detection of oseltamivirresis tant strains, 4 suggests that novel safe com pounds are necessary for the treatment of H1N1 infection in pregnan cy.
- keywords: antiviral; days; h1n1; h5n1; infection; infl; pregnancy; pregnant; public; sars; singapore; treatment; uenza; virus; women
- versions: original; plain text
- cord-008880-cqbsmrpw
- author: Van Ranst, Marc
- title: Chandipura virus: an emerging human pathogen?
- date: 2004-09-09
- words: 1188
- flesch: 48
- summary: Chadipura: a new arbovirus isolated in Ì ndia from patients with febrile illness Isolation of Chandipura virus from the blood in acute encephalopathy syndrome Isolation of Chandipura virus from sand flies in Aurangabad First isolations of arboviruses from Phlebotomine sand flies in West Africa Oligonucleotide fingerprints of RNA species obtained from rhabdoviruses belonging to the vesicular stomatitis virus subgroup key: cord-008880-cqbsmrpw authors: Van Ranst, Marc title: Chandipura virus: an emerging human pathogen? date: 2004-09-09 journal: Lancet DOI: 10.1016/s0140-6736(04)16995-x sha: doc_id: 8880 cord_uid: cqbsmrpw nan These two trials provide important information on the natural history of node-negative oestrogen-receptor-positive breast cancer, and offer insights into our ability to alter that natural history.
- keywords: adjuvant; benefit; chandipura; chemotherapy; data; encephalitis; india; laboratory; negative; node; nsabp; outbreak; patients; positive; regional; relapse; risk; significant; survival; tamoxifen; trials; unknown; virus
- versions: original; plain text
- cord-008881-579ronfq
- author: Nicholson, KarlG
- title: MULTISITE INTRADERMAL ANTIRABIES VACCINATION: Immune Responses in Man and Protection of Rabbits Against Death from Street Virus by Postexposure Administration of Human Diploid-Cell-Strain Rabies Vaccine
- date: 1981-10-24
- words: 2887
- flesch: 40
- summary: WHO consultation on cell culture rabies vaccines and their protective effect in man Immunoglobulin IgG and IgM antibody responses to rabies vaccine transformed the management of diabetes and it is now administered to about 4 million diabetics throughout the world. We thank Dr C. Charbonnier and l'lnstitut Merieux for the gift of the vaccine Requests for reprints should be addressed to K. G. N. Successful protection of humans exposed to rabies infection Postexposure treatment with the new human diploid cell rabies vaccine and antirabies serum Post-exposure use of human diploid cell culture rabies vaccine Deitch MW Postexposure trial of a human diploid cell strain rabies vaccine Immunization with a human diploid cell strain of rabies virus vaccine: two year results Studies with human diploid cell strain rabies vaccine and human rabies immunoglobulin in man Human diploid cell strain rabies vaccine rapid prophylactic immunisation of volunteers with small doses Immune responses of humans to a human diploid cell strain of rabies virus vaccine: lymphocyte transformation, production of virus-neutralizing antibody, and induction of interferon L'injecteur sans aiguille Dermo-jet Presse Mé Quantitative assay and potency test of antirabies serum and immunoglobulin MacNaughton MR Enzyme linked immunosorbent assay for detection of antibody in volunteers experimentally infected with human coronavirus 229 E group viruses Purification of human T and B lymphocytes Immunogenicity and acceptability of a human diploid cell culture rabies vaccine in volunteers Rabies prophylaxis simplified Resultats de la vaccination antirabique preventive par le vaccin inactive concentre souche Rabies PM/W138-1503-3M cultivee sur cellules diploides humaines Developments in Biological Standardisation Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine A large scale antirabies immunisation study in humans using HDCS vaccine.
- keywords: antibody; antirabies; blood; cell; culture; days; diploid; doses; formulations; hdcs; hdcs vaccine; human; i.d; igg; immune; insulin; intradermal; lymphocytes; method; monograph; needle; pharmacopoeia; postexposure; present; protection; rabbits; rabies; rabies vaccine; response; route; sites; strain; street; study; substantial; titres; transformation; treatment; vaccination; vaccine; virus; volunteers
- versions: original; plain text
- cord-008917-ek8rp4kh
- author: Caul, E.O.
- title: CORONAVIRUS-LIKE PARTICLES IN DIARRHOEA STOOLS
- date: 1980-12-06
- words: 943
- flesch: 40
- summary: First, it ensures that a high proportion of mole patients receive potentially mutagenic cytotoxic agents during their childbearing period, whereas others think it desirable to avoid such exposure. 4 Blastocystis hominis, an intestinal protozoan parasite of man Coronavirus particles in faeces from patients with gastroenteritis Recognition of human enteric coronaviruses by electron microscopy Coronavirus propagated from patients with non-bacterial gastroenteritis Further studies on human enteric coronaviruses Replication of an enteric bovine coronavirus in intestinal organ cultures The human enteric coronaviruses 28% of euthyroid subjects with an exaggerated response to TRH have neither thyroid antibodies nor a history of partial thyroid ablation (unpublished) Charing Cross Hospital Relationship of oral contraception to development of trophoblastic tumour after evacuation of a hydatidiform mole Drug safety in porphyria The value of determining the plasma concentration of drugs in animals and man.
- keywords: colleagues; coronavirus; culture; dangerous; drugs; enteric; faeces; findings; hormone; human; intestinal; like; mole; particles; patients; response; risk; subjects; thyroid
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- cord-008926-ntv18e1s
- author: Han, Qide
- title: China and global health
- date: 2008-10-17
- words: 1903
- flesch: 48
- summary: Despite accounting for over a fi fth of the world's population, the importance of China to global health has been under-recognised by the international health community. There are at least four reasons, contemporary and historical, for China's growing role in global health.
- keywords: care; challenges; china; chinese; chronic; community; countries; country; development; diseases; eff; emergence; example; future; global; health; importance; infectious; international; lancet; major; medical; medicine; new; people; quality; report; research; role; scale; social; system; threats; traditional; transitions; unique; world
- versions: original; plain text
- cord-008995-p89e6620
- author: Krogh, Palle
- title: FUNGAL TOXINS AND ENDEMIC (BALKAN) NEPHROPATHY
- date: 1976-07-03
- words: 831
- flesch: 52
- summary: In the search for an environmental cause of E.N. ochratoxin A seems a likely candidate. The results show (figure A) that in 122 out of 125 samples rT3 levels were 4-9 times above the normal adult range.
- keywords: blood; cases; cord; e.n; endemic; fungal; h.d.l; levels; lipoprotein; meat; nephropathy; normal; ochratoxin; pork; rt3; serum
- versions: original; plain text
- cord-009002-790bee3v
- author: Schoub, BarryD
- title: ENTERIC ADENOVIRUSES AND ROTAVIRUSES IN INFANTILE GASTROENTERITIS IN DEVELOPING COUNTRIES
- date: 1981-10-24
- words: 896
- flesch: 43
- summary: Diet and the faecal microflora of infants, children and adults in rural Nigeria and urban U.K Drugs and the hepatic porphyrias Joubert SM Effect of ethanol on liver delta-aminoaevulinate synthase in rats Lancet A Acute ethanol ingestion and haem biosynthesis in healthy subjects Goldberg A Abnormal haem biosynthesis in chronic alcoholics International review of drugs in acute porphyria Goldberg A Haematin therapy for acute hepatic porphyria 5 5 With recommends more liberal use of drugs as well as of alcohol in porphyria patients.
- keywords: acute; adenoviruses; alcohol; attacks; black; detection; drugs; electron; ethanol; experience; haem; patients; porphyria; rotavirus; rural; synthase; urban
- versions: original; plain text
- cord-009027-uqsayb4d
- author: Sirtori, Carlo
- title: AUSTRALIA ANTIGEN, CORONAVIRUS, AND REVERSE TRANSCRIPTASE IN VIRAL HEPATITIS
- date: 1971-07-31
- words: 937
- flesch: 61
- summary: revealing the simultaneous presence of Australia antigen and coronaviruses, and showing how the particles of Australia antigen, present in the cytoplasm, fell together to form coronavirus membranes. We have tried to cultivate bits of hepatitis liver containing both the Australia antigen and the coronavirus on KB cells,5 and we have seen that the KB cells developed clusters of particles in their cytoplasm, suggesting the early stages of Australia-antigen formation; on the other hand, Perhaps the coronavirus, or adult form of the virus, occurs only exceptionally or is very short-lived.
- keywords: antigen; australia; bilirubin; blood; cells; changes; coronavirus; g.o.t; hepatitis; hospital; liver; s.f; units; weeks
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- cord-009089-hmfd0xws
- author: Stein, H.
- title: IDENTIFICATION OF A T CELL LYMPHOMA CATEGORY DERIVED FROM INTESTINAL-MUCOSA-ASSOCIATED T CELLS
- date: 1988-11-05
- words: 1308
- flesch: 40
- summary: Isaacson reported another case of intestinal T cell lymphoma associated with coeliac disease that was reactive with the HML-1 antibody. The negative reaction of all other T cell lymphomas, including those with primary involvement of lymph nodes, skin, mediastinum, and stomach, indicates that the specificity of the mAb HML-1 for intestinal mucosa T cells holds true for cells that have undergone malignant transformation.
- keywords: antibodies; antibody; case; cell; coeliac; decision; disease; histiocytosis; intestinal; jejunitis; jejunum; lamina; lymphocytes; lymphoma; mab; malignant; monoclonal; mucosa; nodes; primary; propria; specific; tumour; ulcerative
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- cord-009096-3c5t70an
- author: Frankish, Helen
- title: New WHO chief promises greater commitment to HIV/AIDS
- date: 2003-07-26
- words: 1378
- flesch: 41
- summary: Together, learning from the past, we can change the future of global health. Mentored by senior WHO staff, these young professionals will form part of the next generation of international health leaders, he said.
- keywords: aids; assistant; cluster; communicable; development; director; diseases; general; global; goals; head; headquarters; health; hiv; international; lee; new; partners; resources; sars; staff; target; work; years
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- cord-009137-wj5vhvxx
- author: Fananapazir, L.
- title: RAISED URINARY FIBRIN-DEGRADATION PRODUCTS, COMPLEMENT, AND IgG DURING AN INFLUENZA-LIKE ILLNESS
- date: 1977-04-30
- words: 2137
- flesch: 42
- summary: One would expect to find differences in factors which control bilirubin concentration in a group of people with a high bilirubin if they are compared with those with a lower bilirubin. Failure to recognise that the distribution of bilirubin concentration is skewed and the subsequent misapplication of gaussian statistical techniques can yield a misleadingly low upper limit of normal.
- keywords: antibody; bilirubin; blood; complement; concentration; controls; degradation; disease; evidence; f.d.p; fibrin; gilbert; glomerulonephritis; igg; illness; immune; infection; influenza; like; normal; patients; population; products; respiratory; serum; study; symptoms; syndrome; upper; urinary; urine; viral; viruses
- versions: original; plain text
- cord-009144-3slh1nbk
- author: Jacobs, J.W.
- title: RESPIRATORY SYNCYTIAL AND OTHER VIRUSES ASSOCIATED WITH RESPIRATORY DISEASE IN INFANTS
- date: 1971-05-01
- words: 3289
- flesch: 57
- summary: Age Table I shows virus infections diagnosed in infants of different ages. Gardner et al. 3 present persuasive evidence in support of the postulate that the development of immediate hypersensitivity plays a dominant role in the pathogenesis of acute bronchiolitis in R.s. infections.
- keywords: acute; admission; age; antibody; antigen; bristol; c.f; cause; chest; days; diagnosis; evidence; heart; hospital; illness; infants; infections; isolation; life; lower; maternal; months; parainfluenza; prednisolone; r.s; r.s.-virus; rejection; respiratory; serology; severe; severity; signs; specimens; swabs; table; throat; tract; type; virus; viruses
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- cord-009153-zxx4m1kz
- author: Heymann, David L
- title: Dangerous pathogens in the laboratory: from smallpox to today's SARS setbacks and tomorrow's polio-free world
- date: 2004-05-15
- words: 2792
- flesch: 42
- summary: Proven measures to minimise the risk of reintroducing dangerous pathogens include: limiting the number of sites where they are stored and studied to those that are absolutely necessary; protection of laboratory workers with available vaccines, protective clothing, and safe equipment; closely monitoring illnesses in laboratory workers; and adhering to standard operating procedures. Unlike SARS-CoV, poliovirus is not efficiently transmitted by droplets from person to person, and a vaccine is available that fully protects laboratory workers from disease and reduces the risk of infection, thereby providing additional assurances against substantial consequences should a laboratory accident occur once routine immunisation with oral poliovirus vaccine has stopped.
- keywords: accident; age; biosafety; cannabis; cases; certification; china; conditions; cov; dangerous; drugs; eradication; global; guidelines; health; human; immunisation; infection; investigation; laboratories; laboratory; long; materials; national; oral; organization; outbreak; pathogens; poliomyelitis; poliovirus; procedures; production; risk; routine; sars; smallpox; source; transmission; use; vaccine; wild; workers; world; years
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- cord-009160-e2qh3xd8
- author: Unger, Jean-Pierre
- title: Public health implications of world trade negotiations
- date: 2004-01-03
- words: 803
- flesch: 41
- summary: It could be invoked by powerful health services companies in countries with a weak bargaining position, to prevent publicly oriented services from receiving government subsidies or oblige subsidised public services to limit their activities to disease control. In conclusion, Pollock and Price refer to a process in which governments lose rights to regulate and to protect economic values and the principles that shape provision of public services.
- keywords: article; control; countries; disease; gats; health; incision; international; lancet; lateral; midline; paramedian; pollock; price; public; sector; services; trade; wto
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- cord-009230-muvoo3pe
- author: Chen, Zhu
- title: Biomedical science and technology in China
- date: 2008-10-17
- words: 1277
- flesch: 37
- summary: Yet China faces several challenges, including: the need to develop a sound infrastructure for health-care insurance; a lack of eff ective partnership between the academic and industrial sectors; insuffi cient investment in drug research and development; and unsatisfactory support for the oversight of food and drug safety. At present, the country is concentrating on primary health care in rural areas and community medicine in cities.
- keywords: biotechnology; care; cells; china; chinese; clinical; development; diseases; drug; food; genomics; health; human; infl; international; key; major; medicine; national; primary; projects; protein; research; respiratory; rst; sars; science; stem; system; technology; therapy; uenza; use
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- cord-009234-v4wlz3fa
- author: Merianos, Angela
- title: International Health Regulations (2005)
- date: 2005-10-06
- words: 1896
- flesch: 33
- summary: The new IHR 2005 goes some way toward addressing these issues by establishing expert panels to review the risks to international public health and recommend evidence-based control measures. 3, 4 In the past 10 years, new and emerging infectious diseases with a potential threat to international public health include Ebola, Lassa, and Marburg haemorrhagic fevers in Africa, variant Creutzfeldt-Jakob disease in Europe, meningococcal meningitis W135 associated with returning Hajj pilgrims, Nipah virus in Malaysia, West Nile virus in the Americas, severe acute respiratory syndrome, and the pandemic threat from avian influenza H5N1 in Asia.
- keywords: acute; assembly; blood; control; countries; diseases; event; exercise; global; health; hypertension; ihr; infectious; influenza; international; new; organization; outbreak; potential; pressure; public; reduction; regular; regulations; respiratory; response; risk; seizures; severe; significant; spread; syndrome; threats; trade; travel; unusual; world
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- cord-009285-1ddfywfa
- author: Assicot, M.
- title: High serum procalcitonin concentrations in patients with sepsis and infection
- date: 1993-02-27
- words: 2596
- flesch: 29
- summary: key: cord-009285-1ddfywfa authors: Assicot, M.; Bohuon, C.; Gendrel, D.; Raymond, J.; Carsin, H.; Guilbaud, J. title: High serum procalcitonin concentrations in patients with sepsis and infection date: 1993-02-27 journal: Lancet DOI: 10.1016/0140-6736(93)90277-n sha: doc_id: 9285 cord_uid: 1ddfywfa High concentrations of calcitonin-like immunoreactivity have been found in the blood of patients with various extrathyroid diseases. Plasma immunoreactive-calcitonin in patients with non-thyroid tumours Hypersecretion of calcitonin in neoplastic conditions Increased serum and urinary calcitonin levels in patients with pulmonary disease Hypercalcitoninemia in acute pancreatitis Serum calcitonin in acute pancreatitis in man Calcitonin levels in chronic renal disease Immunoreactive parathyroidhormone and calcitonin in plasma and ultrafiltrate before and after haemodialysis Identification and measurement of calcitonin precursors in serum of patients with malignant diseases Hypercalcitoninaemia in fulminant meningococcaemia in children Immunochemical heterogeneity of calcitonin in tumor, tumor venous effluent and peripheral blood of patients with medullary thyroid carcinoma Immunochemical heterogeneity of calcitonin in plasma Medullary thyroid carcinoma secretes a non-calcitonin peptide corresponding to the carboxylterminal region of preprocalcitonin Diagnostic relevance of the amino-terminal cleavage peptide of procalcitonin (PAS-57), calcitonin and calcitonin gene-related peptide in medullary thyroid carcinoma patients Structural characterization of a high-molecular-mass form of calcitonin [procalcitonin-(60-116) -peptide] and its corresponding N-terminal flanking peptide [procalcitonin-(1-57)-peptide] in a human medullary thyroid carcinoma Immunocytochemical localization of calcitonin in Kultschitzky cells of human lung A novel calcitonin carboxy-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene Calcitonin gene-related peptide levels are elevated in patients with sepsis Endogenous fibrinolysis may play a part in acute upper-gastrointestinal-tract bleeding by causing digestion of haemostatic plugs.
- keywords: acute; assay; bacterial; bleeding; blood; calcitonin; carcinoma; cells; children; concentrations; diseases; extrathyroid; fdp; gastrointestinal; gene; high; immunoreactivity; infants; infection; like; mature; medullary; normal; outcome; patients; peptide; precursors; procalcitonin; range; sepsis; septic; serum; severe; study; subgroup; thyroid; tract; upper
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- cord-010170-rwf52bly
- author: Sutrisna, B.
- title: Randomised, controlled trial of effectiveness of ampicillin in mild acute respiratory infections in Indonesian children
- date: 1991-08-24
- words: 2940
- flesch: 42
- summary: Even if antibiotics are widely available, use of ineffective treatment for many mild ARI cases will substantially reduce the cost-effectiveness of ARI treatments in general. key: cord-010170-rwf52bly authors: Sutrisna, B.; Frerichs, R.R.; Reingold, A.L. title: Randomised, controlled trial of effectiveness of ampicillin in mild acute respiratory infections in Indonesian children date: 1991-08-24 journal: Lancet DOI: 10.1016/0140-6736(91)90544-y sha: doc_id: 10170 cord_uid: rwf52bly The recommended treatment for mild acute respiratory infections (ARI) in children is supportive care only, but many physicians, especially in developing countries, continue to prescribe antibiotic treatment because they believe it prevents progression to more severe ARI.
- keywords: acute; age; ampicillin; antibiotics; ari; benefit; bph; care; cases; children; clinical; community; control; countries; days; disease; fever; groups; health; history; indonesian; infections; mild; mild ari; moderate; necropsy; nose; physicians; prostatic; respiratory; severe; study; supportive; supportive care; survey; table; treatment; trial; upper; week; weight; years
- versions: original; plain text
- cord-010255-gvkc2hjd
- author: Chrystie, I.L.
- title: ASYMPTOMATIC ENDEMIC ROTAVIRUS INFECTIONS IN THE NEWBORN
- date: 1978-06-03
- words: 1638
- flesch: 47
- summary: 1) In Haydon ward rotavirus infection among newborn babies was mild or more often symptomless. It is not known why rotavirus infection is mild or symptomless in the newborn human.
- keywords: babies; breast; cells; children; circulating; day; diarrhoea; excreted; frequent; hospital; human; infants; infected; infection; mary; mild; myeloma; newborn; nurseries; older; particles; patients; rotavirus; stools; symptomless; wards; wing
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- cord-020267-0axms5fp
- author: None
- title: RIBAVIRIN AND RESPIRATORY SYNCYTIAL VIRUS
- date: 1986-02-15
- words: 1846
- flesch: 33
- summary: Effective therapy with ribavirin Mechanisms of action of ribavirin Report to the Medical Council Subcommittee on respiratory syncytial virus vaccines Respiratory syncytial virus infection: admissions to hospital in industrial, urban, and rural areas Pneumonia: an eleven-year study in a pediatric practice Respiratory syncytial viral infection in infants with congenital heart disease Respiratory syncytial virus in immunocompromised children Communicable Disease Surveillance Centre. Respiratory syncytial virus infection in the elderly 1976-82
- keywords: audit; authorities; care; cases; children; congenital; disease; diversion; dysplasia; effects; external; fpcs; general; health; heart; high; improvement; incontinence; infants; infection; management; medicine; multiple; operation; patients; practice; practitioners; respiratory; ribavirin; rsv; sclerosis; structure; syncytial; therapy; treatment; urinary; viral; virus
- versions: original; plain text
- cord-020270-5mvzjrdg
- author: None
- title: Balkan Nephropathy
- date: 1977-03-26
- words: 1352
- flesch: 45
- summary: A family history of Balkan nephropathy is found in about 1 in 5 cases in the endemic area. The incidence of Balkan nephropathy within the endemic area is variable, but levels as high as 10% of the population have been claimed for some villages with perhaps 30% of individuals showing symptomless proteinuria.
- keywords: age; area; balkan; balkan nephropathy; bgr;2; changes; cyclopium; disease; endemic; fungi; high; history; hypertension; individuals; lesions; local; microglobulin; nephropathy; parts; patients; possible; proteinuria; renal; tubular; var; verrucosum; years
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- cord-020301-5jugyncm
- author: None
- title: REFERENCES AND ABBREVIATIONS
- date: 1984-07-07
- words: 3056
- flesch: -7
- summary: Citrullinaemia-chorionic biopsy in diagnosis (Kleljer et al) (C) 1340 Claudication, intermittent—ketanserin in (DeCree et at) 775, (Fonseca et al) (C) 1212 'cling film'—in central venous catheterisation (Panning) (C 1045 Clinical Atlas of Human Chromosomes (Grouchy and Turleau) (NE) 380 Clinical Biochemistry of the Elderly (Hodkinson) (Brewin) (C) 164, (Silverman) (C) 164; Zelen randomisation in (Gore) (C) 226 Clinical Tropical Diseases (Maegraith) (NE) 1076 Clinicians-in management (Chantler) (C) 102 Clofibrate-in prevention of IHD (Oliver et al) 600, (Green) (C) 1095, (Oliver et at) (C) 1096 Clonidine—intrathecal, neurotoxicity of (Tamsen and Gordh) (C) 231, (Coombs) (C) 689, (Tamsen and Gordh) (C) 876 Clostridium spp-two toxins from in diarrhoea (Borriello et al) (C) 1218 Childbirth—in Holland, 534; injury to pelvic floor muscle innervation in (Snooks et al) 546; at weekends (Cole) (C) 222, (Newton) (C) 470, (Paccaud et al) (C) 470, (Macfarlane) (C) 695 Children—addiction to video games, 1226; Child Abuse (Carmi and Zimrin) (Sibert) (R) 959; child care law, working party and, 360, Children (Gray and Cockburn) (Moore) (R) 260; CNS symptoms with ramtidine in (De Galcomo et al) (C) 47; depression in (Davis) (C) 45; deprivation and hospital admissions (Maclure and Stewart) 682, (Rosenberg) (C) 814, (West) (C) 814; fictitious epilepsy in (Meadow) 25; in hospital, charter for, 1350; and medical research (Pearn) 510; mortality of in The Gambia (Lamb et al) 912, (Lohse) (C) 1215, (Northrup) (C) 1215; pneumonia m. Papua New Guinea (Shann et al) 537; research and (Pearn) 510, (Silverman) (C) 755, sexual abuse of, report, 1350 Children (Gray and Cockburn) (Moore) (R) 260 Child-resistant packaging-for household goods, 300 China-stomach cancer in, 362 Chlamydia trachomatis-rapid detection (Taylor et al) (C) 38, (Hawkins et al) (C) 38, (Berrón et al) (C) 109; screening urine for (Adger et al) 944 Chlorambucil-and chromosome damage (Palmer et al) (C) 174 Chlorhexidineand WHO essential drug list (Denton) (C) 517, (Kahan et al) (C) 759, (Fowler) (C) 760 Chlorophenols-and cancer (Olsen and Jensen) (C) 47, (Gallagher and Threlfall) (C) 48, (correction) 826 Chloroquine—intramuscular, in children (Trigg et al) (C) 288; response to immunisation and (Greenwood) C 402 Cholecystectomy rates-and gallstone prevalence (Bateson) 621, (MPherson et al) (C) 1092 Cholera-alum in prevention of (Khan et al) (C) Chorion biopsy-and argininosuccinicaciduria diagnosis (Vimal et al) (C) 521; for citrullinaemia and methylmalonicaciduria (Kleijer et al) (C 1340; haemophilia B diagnosis (Tnnesen et al) (C) 932; haemophilia diagnosis in twin pregnancy (Mulcahy et al) (C) 866; rhesus isoimmunisation and (Kanhai et al) (C) 157
- keywords: abuse; africa; aids; babies; bacterial; biopsy; blood; brahams; breast; cancer; care; cell; cervical; child; children; chorionic; clinical; correction; damage; deitch; detection; diagnosis; disease; elderly; et al; factor; failure; fever; gosden; growth; guide; haemophilia; hart; health; hughes; human; hypertension; immune; jensen; lancet; levels; lohse; macgregor; marker; maury; mitchell; mortality; oliver; plasma; pregnancy; prevention; primary; protein; rabbitts; reactive; renal; report; research; screening; serum; smith; survival; syndrome; transplantation; tumour; urinary; urine; usa; vaccines; valproate; viral
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- cord-020316-xr9h4c1q
- author: None
- title: Million women study most wanted in 2003
- date: 2004-04-10
- words: 224
- flesch: 11
- summary: Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial Coronavirus as a possible cause of severe acute respiratory syndrome Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial Advances in cystic fibrosis Cystic fibrosis Elusive schizophrenia genes Genes for schizophrenia? Recent findings and their pathophysiological implications Detecting ovarian cancer Use of proteomic patterns in serum to identify ovarian cancer Heart Protection Study Collaborative Group.
- keywords: cholesterol; group; heart; lowering; protection; randomised; study; trial
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- cord-023622-tul7bonh
- author: None
- title: Rotaviruses of Man and Animals
- date: 1975-02-01
- words: 1953
- flesch: 43
- summary: Stools may be extremely rich in virus particles-there may be 109 to 1010 particles per gramme of faeces. Virus-infected organ cultures may be used for titrating antibody by I.F., and this provides a method that is rather more sensitive than c.F.; an effective c.F. antigen may be simply prepared from stool extracts rich in virus particles.
- keywords: blood; c.f; calf; cause; children; clinic; colleagues; diarrhoea; diseases; electron; extracts; gastroenteritis; high; human; illness; important; like; microscopy; mortality; particles; patients; periods; pressure; recordings; records; rotaviruses; specimens; therapy; treatment; viruses; workers
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- cord-027472-pr037x2t
- author: Gaffney, Adam W
- title: US law enforcement crowd control tactics at anti-racism protests: a public health threat
- date: 2020-06-19
- words: 538
- flesch: 42
- summary: key: cord-027472-pr037x2t authors: Gaffney, Adam W; McCormick, Danny; Woolhandler, Steffie; Himmelstein, David U title: US law enforcement crowd control tactics at anti-racism protests: a public health threat date: 2020-06-19 journal: Lancet DOI: 10.1016/s0140-6736(20)31421-5 sha: doc_id: 27472 cord_uid: pr037x2t nan Numerous videos document law enforcement officers' indiscriminate use of chemical irritants and kinetic impact projectiles (KIPs); striking peaceful protesters, and even jour nalists, with batons, fists, and vehicles; and corralling crowds in confined areas, making physical distancing impossible. In one well publicised incident, officers used chemical irritants to chase peaceful protesters from a square near the White House to clear a path for President Trump to attend a photo opportunity.
- keywords: chemical; covid19; enforcement; gas; health; irritants; kips; law; pandemic; protesters; review; tear; use
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- cord-033974-0rzi7x22
- author: Boyd, Rhea W
- title: In the 2020 US election, we can choose a just future
- date: 2020-10-19
- words: 1428
- flesch: 59
- summary: But while the founding fathers anchored their fledgling democracy in inequality, the expansion of US democracy owes its fragile progress to many forebearers, chief among them are the Indigenous, the formerly enslaved, and women. key: cord-033974-0rzi7x22 authors: Boyd, Rhea W; Krieger, Nancy; Jones, Camara Phyllis title: In the 2020 US election, we can choose a just future date: 2020-10-19 journal: Lancet DOI: 10.1016/s0140-6736(20)32140-1 sha: doc_id: 33974 cord_uid: 0rzi7x22 nan When US voters go to the polls (what few are left) or attempt to mail our ballots (with what remains of the US postal service) in the 2020 election, we are not simply choosing between two parties or posturing about partisan politics.
- keywords: administration; black; communities; coronavirus; country; covid-19; current; deaths; democracy; economic; future; health; hispanic; indigenous; inequities; largest; lives; nation; new; pandemic; people; racism; rights; times; trump; usa; voters; white; world; york
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- cord-034160-k2oy3avl
- author: None
- title: Department of Error
- date: 2020-10-22
- words: 381
- flesch: 47
- summary: In a call to action, Arlene King and colleagues 1 emphasise the potential for insolvency at the Pan American Health Organization (PAHO) and urge member states to pay their outstanding contributions. King and colleagues also argued that health security will not be possible without a functioning PAHO; however, it is imperative to note that a functioning PAHO entails more than securing funding from member states.
- keywords: colleagues; funding; health; king; member; paho; solidarity; states
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- cord-034165-kf6a8hix
- author: Mendenhall, Emily
- title: The COVID-19 syndemic is not global: context matters
- date: 2020-10-22
- words: 456
- flesch: 50
- summary: Recognising contexts are different matters a great deal. These synergistic failures have caused more death and devastation than many other contexts.
- keywords: contexts; coronavirus; covid-19; global; health; leadership; matters; political; syndemic; usa
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- cord-252801-97edhhkt
- author: Calisher, Charles
- title: Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19
- date: 2020-02-19
- words: 466
- flesch: 50
- summary: key: cord-252801-97edhhkt authors: Calisher, Charles; Carroll, Dennis; Colwell, Rita; Corley, Ronald B; Daszak, Peter; Drosten, Christian; Enjuanes, Luis; Farrar, Jeremy; Field, Hume; Golding, Josie; Gorbalenya, Alexander; Haagmans, Bart; Hughes, James M; Karesh, William B; Keusch, Gerald T; Lam, Sai Kit; Lubroth, Juan; Mackenzie, John S; Madoff, Larry; Mazet, Jonna; Palese, Peter; Perlman, Stanley; Poon, Leo; Roizman, Bernard; Saif, Linda; Subbarao, Kanta; Turner, Mike title: Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19 date: 2020-02-19 journal: Lancet DOI: 10.1016/s0140-6736(20)30418-9 sha: doc_id: 252801 cord_uid: 97edhhkt nan We are public health scientists who have closely followed the emergence of 2019 novel coronavirus disease and are deeply concerned about its impact on global health and wellbeing. We sign this statement in solidarity with all scientists and health professionals in China who continue to save lives and protect global health during the challenge of the COVID-19 outbreak.
- keywords: china; covid-19; global; health; medical; outbreak; professionals; public; scientists; support
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- cord-253035-tijcxtwx
- author: Wang, Chen
- title: A novel coronavirus outbreak of global health concern
- date: 2020-01-24
- words: 1852
- flesch: 41
- summary: However, current interim guidance from WHO on clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected (released Jan 28, 2020) advises against the use of corticosteroids unless indicated for Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury Geneva: Geneva, World Health Organization Beijing: China National Health Commission Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected.
- keywords: acute; care; cases; china; clinical; control; coronavirus; data; disease; early; fatality; generation; geneva; health; hospital; infected; infection; mers; ncov; novel; organization; outbreak; patients; person; public; respiratory; risk; sars; severe; spread; syndrome; transmission; workers; world
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- cord-253402-6sgeraws
- author: Remuzzi, Andrea
- title: COVID-19 and Italy: what next?
- date: 2020-03-13
- words: 2848
- flesch: 51
- summary: The value of the exponent can be computed as r=0·225 (1 per day) and is consistent with the number of infected patients reported by the Italian Health Ministry. If the increase in the number of infected patients follows this trend for the next week, there will be more than 30 000 patients infected by March 15, as shown in figure 1B .
- keywords: beds; capacity; care; china; cov-2; covid-19; data; days; exponential; facilities; health; infected; intensive; intensive care; italian; italy; march; measures; national; number; outbreak; patients; people; region; sars; system; trend; units; weeks; years
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- cord-254187-dcdc6sqi
- author: Kimball, AM
- title: “What, me worry?” Businesses and AIDS at Davos
- date: 2005-04-05
- words: 1837
- flesch: 54
- summary: 2 -as it does in many of South Africa's mining companies which, not surprisingly, have pioneered inhouse AIDS treatment. The corporate sector is shouldering more responsibility for the health of its workforce than it ever has in the past, says Bernie Clark of the health-care consulting team of Alexander Forbes, a firm that advises businesses on employee benefits and has helped several companies to develop AIDS policies (Clark B, Alexander Forbes, Johannesburg, South Africa, personal communication).
- keywords: africa; aids; asia; asthma; awareness; business; china; coalition; companies; costs; drugs; economic; education; epidemic; firms; forum; global; health; hiv; india; people; pregnancy; private; programmes; risk; sector; south; survey; thailand; treatment; workplace; world
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- cord-254708-3d3abhg5
- author: Herten-Crabb, Asha
- title: Why WHO needs a feminist economic agenda
- date: 2020-03-26
- words: 1785
- flesch: 39
- summary: 4 A feminist economic approach is consistent with how public health is taught and sometimes practised: that health, and access to health care, is interdependent not only on the economy but also on all other social and commercial determinants of health. Such a position, they argued, would enable WHO to better advocate for greater recognition of, and thus action on, the interdependency of health and the economy.
- keywords: agenda; alcohol; approach; bank; board; care; countries; decision; determinants; economic; equality; executive; feminist; gender; global; harm; health; imf; income; institutions; international; low; making; policies; policy; political; social; strategy; use; women; world
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- cord-255628-bm4nogig
- author: Su, Shuo
- title: MERS in South Korea and China: a potential outbreak threat?
- date: 2015-06-11
- words: 1180
- flesch: 54
- summary: These developments are worrisome given Favipiravir-a prophylactic treatment for Ebola contacts? Such a scenario is possible in people who contract Ebola virus before vaccination.
- keywords: case; china; contacts; coronavirus; cov; east; ebola; favipiravir; infections; korea; mers; middle; old; patient; prophylactic; respiratory; south; syndrome; vaccination; year
- versions: original; plain text
- cord-256121-9bl1ztuc
- author: Reid, Michael J A
- title: Building a tuberculosis-free world while responding to the COVID-19 pandemic
- date: 2020-10-22
- words: 1303
- flesch: 34
- summary: Despite these challenges, there are opportunities for synergy to expand tuberculosis programmes, strengthen tuberculosis response, and increase resources towards ending tuberculosis as governments mobilise COVID-19 response efforts while maintaining existing tuberculosis programmes. We calculated the health spending due to these additional incident cases of tuberculosis using estimates of government tuberculosis spending per case 12 and outof-pocket spending on tuberculosis care and projected the additional annual health-care costs that would result from these excess tuberculosis cases in India, Kenya, and Ukraine.
- keywords: additional; care; cases; commission; costs; covid-19; free; global; health; impact; incident; increase; india; lancet; lockdown; month; pandemic; recovery; response; spending; tuberculosis; world
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- cord-256146-d599uera
- author: Kuiken, Thijs
- title: Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
- date: 2003-07-26
- words: 5704
- flesch: 43
- summary: Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS. Collectively, these results of laboratory studies of SARS patients and experimental infections of macaques prove that the newly discovered SARS-CoV is the primary causal agent of SARS.
- keywords: acute; alveolar; alveoli; antibody; areas; assay; bronchioles; causal; cause; cells; changes; clinical; cohort; coronavirus; cov; cov infection; culture; damage; days; definition; detection; diffuse; disease; electron; epithelial; experimental; figure; fluid; gene; human; immunohistochemistry; infected; infection; isolated; isolation; kidney; lesions; lung; macaques; macrophages; medical; metapneumovirus; microscopy; min; nasal; negative; pair; particles; pathogens; patients; pcr; pneumocytes; polymerase; positive; postmortem; presence; primary; primer; pulmonary; respiratory; rna; samples; sars; sars patients; sections; severe; specific; study; swabs; syncytia; syndrome; tcid; tissue; type; use; van; vero; virus; walls
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- cord-256459-6h358si5
- author: Sharpstone, D
- title: Gastrointestinal manifestations of HIV infection
- date: 1996-08-10
- words: 3646
- flesch: 29
- summary: 6 In the last review some of the included trials were Acute HIV infection presenting with painful swallowing and esophageal ulcers Natural history and prognosis of diarrhoea of unknown cause in patients with acquired immunodeficiency syndrome (AIDS) Effects of zidovudine treatment on the small intestinal mucosa in patients infected with the human immunodeficiency virus Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine Intestinal mucosal inflammation associated with human immunodeficiency virus infection Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms Duodenal mucosal T cell subpopulation and bacterial cultures in acquired immunodeficiency syndrome Association of gastric hypoacidity with opportunistic enteric infections in patients with AIDS Decreased gastric acid secretion and bacterial colonisation of the stomach in severely malnourished Bangladeshi children Prevalance of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome Infectious diarrhea in patients with AIDS Gastrointestinal symptoms in patients infected with human immunodeficiency virus: relevance of infective agents isolated from gastrointestinal tract Prevalence of intestinal protozoans in French patients infected with AIDS Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation Faecal tumour necrosis factor-alpha in HIV-related diarrhoea The diagnosis of AIDS-related chronic diarrhoea: a prospective study in 155 patients Light and electron microscopic appearances of pathological changes in HIV gut infection Enterotoxic effect of stool supernatant of Cryptosporidium-infected calves on human jejunum Jejunal water and electrolyte transport in AIDS-related cryptosporidiosis Small bowel transit in HIVseropositive individuals Autonomic denervation in jejunal mucosa of homosexual men infected with HIV Loss of mucosal CD4 lymphocytes is an early feature of HIV infection Mechanisms of innate and acquired resistance to Cryptosporidium parvum infection in SCID mice Cryptosporidium infection in an adult mouse model: independent roles for IFN-� and CD4+ T lymphocytes in protective immunity Faecal tumour necrosis factor-alpha and faecal alpha-one-antitrypsin in HIV infection Diarrhoea in HIV-infected patients: no evidence of cytokine-mediated inflammation in jejunal mucosa An algorithm for the investigation of diarrhoea in HIV infection Use of the fluorochrome Calcofluor white in the screening of stool specimens for spores of microsporidia Salmonella, campylobacter and shigella in HIV positive patients Gastrointestinal viral infections in homosexual men who were symptomatic and seropositive for human immunodeficiency virus Efficient management of diarrhea in the acquired immunodeficiency syndrome (AIDS): a medical decision analysis Cytomegalovirus in AIDS: presentation in 44 patients and a review of the literature Spectral and sequence similarity between vasoactive intestinal peptide and the second conserved region of human immunodeficiency virus type 1 envelope glycoprotein (gp 120): possible consequences on prevention and therapy of AIDS Elevated plasma levels of vasoactive intestinal peptide in AIDS patients with refractory idiopathic diarrhea: effects of treatment with octreotide Octreotide therapy of large volume refractory AIDS-associated diarrhea: a randomized controlled trial Treatment with albendazole for intestinal disease due to Enterocytozoon bieneusi in patients with AIDS Thalidomide for microsporidiosis Atrovaquone is effective treatment for the symptoms of gastrointestinal microsporidiosis in HIV-1 infected patients Paromomycin for cryptosporidiosis in AIDS: a Health Information Research Unit Intestinal function and injury acquired immunodeficiency syndrome-related cryptosporidiosis Infective dose size studies on Cryptosporidium parvum using gnotobiotic lambs However, there is a consistent increase in small-bowel permeability in HIV-seropositive individuals; 5 this functional abnormality and the minor structural abnormalities of the small bowel mucosa may be due to the immunological changes produced by HIV infection of lamina propria lymphocytes.
- keywords: adherence; agents; aids; analysis; avium; bacterial; biopsy; body; bowel; cause; cd4; cells; clinical; cmv; common; cryptosporidia; cryptosporidiosis; cytomegalovirus; diarrhoea; disease; effective; enteric; follow; gastrointestinal; gut; hiv; human; immunodeficiency; individuals; infected; infection; initial; interventions; intestinal; intracellulare; large; lean; likely; loss; mass; mechanisms; microsporidia; mucosal; negative; opportunistic; pathogens; patients; protozoal; related; response; seropositive; small; starvation; stool; studies; study; symptoms; syndrome; therapy; treatment; villus; virus; weight
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- cord-256888-tdx12ccj
- author: Bradley, Benjamin T
- title: Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
- date: 2020-07-16
- words: 5010
- flesch: 42
- summary: Patient 3 and patient 9 also had microthrombi in the trachea, although in patient 3 this was qualified by chronic tracheostomy. We hypothesise that there was a subclinical period during which lung injury was occurring in COVID-19 patients with organising diffuse alveolar disease who died in the week after symptom onset.
- keywords: acute; admission; alveolar; autopsies; autopsy; btb; cardiac; cases; cause; cells; chronic; clinical; cohort; common; coronavirus; cov-2; covid-19; damage; data; days; diffuse; disease; electron; endothelial; epithelial; evidence; examiner; extrapulmonary; figure; findings; histopathological; immunohistochemistry; infection; injury; kidney; like; liver; lung; lymphocytes; major; medical; microscopy; microthrombi; mortem; negative; novel; office; onset; organising; particles; pathology; patients; pcr; positive; post; present; pulmonary; renal; respiratory; results; rna; samples; sars; sections; series; severe; small; staining; studies; study; symptom; syndrome; testing; time; tissue; type; usa; viral
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- cord-260168-rb7j94dh
- author: Gu, Jiang
- title: H5N1 infection of the respiratory tract and beyond: a molecular pathology study
- date: 2007-09-27
- words: 6314
- flesch: 46
- summary: Our comprehensive investigation of the tissue tropism of H5N1 infl uenza virus, based on two adult autopsies and one fetal autopsy, focuses on the localisation of viral genomic sequences and antigens. In cultures of human tracheobronchial epithelial cells, H5N1 infl uenza viruses have been reported to infect mainly ciliated cells, which express mainly avian infl uenza virus receptors (α-2,3-linked sialic acids), although a limited number of non-ciliated cells (<20% of all infected cells) have also been reported to be infected.
- keywords: analysis; antigens; antisense; associated; autopsies; avian; brain; cases; cation; cells; changes; china; ciliated; clinical; cytoplasm; cytotrophoblasts; data; day; detection; diff; disease; epithelial; fetal; fetus; genomic; gure; h5n1; haemagglutinin; human; hybridisation; immunohistochemistry; infected; infection; infl; infl uenza; lungs; lymph; lymphocytes; macrophages; manuscript; mononuclear; nasba; negative; neurons; nodes; non; nucleoprotein; nucleus; number; organs; pathology; patient; pcr; placenta; positive; previous; probes; replication; respiratory; results; rna; samples; sars; sections; sequences; severe; signals; situ; situ hybridisation; specifi; studies; study; tissue; trachea; transmission; uenza; uenza virus; viral; virus; viruses; webfi; writing
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- cord-260559-n8i52e8q
- author: Peiris, Malik
- title: What can we expect from first-generation COVID-19 vaccines?
- date: 2020-09-21
- words: 1356
- flesch: 33
- summary: key: cord-260559-n8i52e8q authors: Peiris, Malik; Leung, Gabriel M title: What can we expect from first-generation COVID-19 vaccines? date: 2020-09-21 journal: Lancet DOI: 10.1016/s0140-6736(20)31976-0 sha: doc_id: 260559 cord_uid: n8i52e8q nan A first generation of COVID-19 vaccines is expected to gain approval as soon as the end of 2020 or early 2021. These observations suggest that we cannot assume COVID-19 vaccines, even if shown to be effective in reducing severity of disease, will reduce virus transmission to a comparable degree.
- keywords: allocation; antibody; coronavirus; cov-2; covid-19; disease; framework; generation; health; high; immunity; impact; important; infection; influenza; mortality; neutralising; population; pre; protection; respiratory; risk; sars; severe; syndrome; transmission; vaccines; virus
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- cord-261011-bcyotwkf
- author: Alkire, Sabina
- title: Global health and moral values
- date: 2004-09-17
- words: 3400
- flesch: 45
- summary: Thus global health may be far easier to achieve if we pause to follow through different moral analyses and thereby clarify what, which, and how global health initiatives can best proceed. 13 Calls for a rights-based approach to global health have recently grown.
- keywords: access; action; advocacy; aggregate; aids; antiretroviral; appeal; approach; capabilities; care; charitable; consensus; development; different; equitable; equity; ethical; example; global; global health; good; health; hiv; human; humanitarianism; important; initiatives; institutions; interests; knowledge; life; moral; obligations; people; political; poor; powerful; programmes; public; resources; rights; schools; self; social; specific; state; suffering; support; tuberculosis; utility; values; work; world
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- cord-261246-m40kwgcg
- author: Chen, Nanshan
- title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
- date: 2020-01-30
- words: 4019
- flesch: 51
- summary: Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient).
- keywords: 2019ncov; acute; admission; ards; bacterial; cases; characteristics; chest; china; chinese; chronic; clinical; comorbidities; coronavirus; data; days; diseases; early; epidemiological; exposure; failure; features; function; history; hospital; human; immune; infection; investigation; jan; jinyintan; laboratory; lymphocytes; market; median; medical; merscov; mortality; mulbsta; multiple; normal; novel; older; organ; outcomes; patients; pneumonia; range; respiratory; result; sarscov; score; severe; status; study; symptoms; syndrome; system; table; time; treatment; viruses; wuhan
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- cord-261559-efbjyuen
- author: Ravi, Krithi
- title: Ethnic disparities in COVID-19 mortality: are comorbidities to blame?
- date: 2020-06-19
- words: 500
- flesch: 40
- summary: key: cord-261559-efbjyuen authors: Ravi, Krithi title: Ethnic disparities in COVID-19 mortality: are comorbidities to blame? date: 2020-06-19 journal: Lancet DOI: 10.1016/s0140-6736(20)31423-9 sha: doc_id: 261559 cord_uid: efbjyuen nan Ethnic disparities in COVID-19 mortality: are comorbidities to blame? In this study, 2 once comorbidities were accounted for, there was no difference in COVID-19 mortality between ethnic groups.
- keywords: bame; comorbidities; covid-19; disparities; ethnic; mortality; patients; risk
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- cord-261791-qpwvn2fi
- author: Qiao, Jie
- title: What are the risks of COVID-19 infection in pregnant women?
- date: 2020-02-12
- words: 1702
- flesch: 38
- summary: As the COVID19 outbreak unfolds, prevention and control of COVID19 infection among pregnant women and the potential risk of vertical transmission have become a major concern. The latest research by Huijun Chen and colleagues 5 reported in The Lancet provides some insight into the clinical characteristics, pregnancy outcomes, and vertical transmission potential of COVID19 infection in pregnant women.
- keywords: cases; china; clinical; colleagues; commission; control; coronavirus; countries; covid19; evidence; feb; health; infection; national; new; number; outbreak; pneumonia; pregnant; prevention; respiratory; sarscov1; severe; study; syndrome; transmission; vertical; women
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- cord-263891-lbcxl6w9
- author: Anderson, Roy M
- title: How will country-based mitigation measures influence the course of the COVID-19 epidemic?
- date: 2020-03-09
- words: 2848
- flesch: 46
- summary: Social distancing measures reduce the value of the effective reproduction number R. With an early epidemic value of R 0 of 2·5, social distancing would have to reduce transmission by about 60% or less, if the intrinsic transmission potential declines in the warm summer months in the northern hemisphere. In both places, COVID19 has been managed well to date, despite early cases, by early government action and through social distancing measures taken by individuals.
- keywords: cases; china; contact; control; coronavirus; countries; covid19; days; disease; distancing; early; economic; epidemic; government; health; impact; individuals; infected; infectious; infectiousness; influenza; key; likely; measures; mitigation; number; pandemic; peak; people; period; place; sars; social; spread; symptoms; time; transmission; vaccine; value
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- cord-264968-ctx39vhi
- author: Woo, Patrick CY
- title: Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia
- date: 2004-03-13
- words: 3573
- flesch: 41
- summary: key: cord-264968-ctx39vhi authors: Woo, Patrick CY; Lau, Susanna KP; Tsoi, Hoi-wah; Chan, Kwok-hung; Wong, Beatrice HL; Che, Xiao-yan; Tam, Victoria KP; Tam, Sidney CF; Cheng, Vincent CC; Hung, Ivan FN; Wong, Samson SY; Zheng, Bo-jian; Guan, Yi; Yuen, Kwok-yung title: Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia date: 2004-03-13 journal: Lancet DOI: 10.1016/s0140-6736(04)15729-2 sha: doc_id: 264968 cord_uid: ctx39vhi BACKGROUND: An ELISA based on recombinant nucleocapsid protein for IgG detection was tested with serum from 149 healthy blood donors who donated 3 years previously and with serum positive for antibodies against SARS-CoV (by indirect immunofluorescence assay) from 106 patients with SARS-CoV pneumonia.
- keywords: -tagged; acute; antibodies; antibody; assays; blood; blot; coronavirus; cov; detection; donors; elisa; healthy; hong; hospital; igg; immunofluorescence; indirect; infections; kong; non; nucleocapsid; nucleocapsid protein; patients; pneumonic; polypeptide; population; positive; protein; purified; recombinant; recombinant nucleocapsid; respiratory; samples; sars; seroprevalence; serum; severe; specific; spike; study; syndrome; test; western; years
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- cord-266835-vfandmy4
- author: Usuelli, Michele
- title: The Lombardy region of Italy launches the first investigative COVID-19 commission
- date: 2020-10-15
- words: 1003
- flesch: 51
- summary: Certain fields of health care, such as hygiene, preventive primary health care, and public health, and networks of general practitioners and hospitals, with all the essential supportive disciplines like epidemiology, have therefore been neglected. The Regional Council of Lombardy has now formed a COVID-19 investigative commission within the regional assembly to analyse the sequence of events and the specific choices that led to so many infections and deaths in a region with an extremely high standard of health care.
- keywords: authorities; care; cases; commission; covid-19; deaths; essential; government; health; investigative; italian; italy; lombardy; ministry; national; pandemic; patients; people; regional
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- cord-268799-obeinwyq
- author: Horton, Richard
- title: Canada 2010: what should global health expect?
- date: 2009-09-24
- words: 1348
- flesch: 57
- summary: key: cord-268799-obeinwyq authors: Horton, Richard title: Canada 2010: what should global health expect? date: 2009-09-24 journal: Lancet DOI: 10.1016/s0140-6736(09)61677-9 sha: doc_id: Over the next 15 months, Canada has an opportunity to make a decisive impact on global health.
- keywords: action; canada; canadian; century; change; climate; commission; community; country; development; foreign; global; health; indigenous; international; japan; lancet; leaders; need; peace; policy; political; public; summit; systems; time; world
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- cord-268947-rh6n0u9n
- author: Frumkin, Howard
- title: Planetary health and the 2020 US election
- date: 2020-09-29
- words: 1324
- flesch: 45
- summary: Climate change policy provides one of the sharpest distinctions between Trump and Biden. The undoing of US climate policy: the emissions impact of Trump-era rollbacks Public health co-benefits of greenhouse gas emissions reduction: a systematic review Health benefits of policies to reduce carbon emissions Adapting to climate change: thresholds, values, governance Successful adaptation to climate change: linking science and policy in a rapidly changing world Connecting global priorities: biodiversity and human health.
- keywords: actions; administration; benefits; biden; biodiversity; change; climate; covid-19; disease; ecosystem; election; emissions; energy; environmental; example; gas; global; health; human; intergovernmental; planetary; policies; policy; presidency; report; science; trump; usa
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- cord-269343-qwgmn06t
- author: Livingston, Gill
- title: Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
- date: 2020-07-30
- words: 23202
- flesch: 38
- summary: A systematic review Computerised cognitive training for maintaining cognitive function in cognitively healthy people in midlife Computerized cognitive training in older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis Everyday impact of cognitive interventions in mild cognitive impairment: a systematic review and meta-analysis Preventing cognitive decline in Black individuals with mild cognitive impairment: a randomized clinical trial Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis Association of subclinical hearing loss with cognitive performance Association of midlife hearing impairment with late-life temporal lobe volume loss Death, depression, disability, and dementia associated with self-reported hearing problems: a 25-year study Association of cognition and age-related hearing impairment in the English longitudinal study of ageing Longitudinal relationship between hearing aid use and cognitive function in older Americans Induction of a transmissible tau pathology by traumatic brain injury ApoE4-associated phospholipid dysregulation contributes to development of tau hyper-phosphorylation after traumatic brain injury The epidemiology of traumatic brain injury: a review Long-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study Traumatic brain injury and the risk of dementia diagnosis: a nationwide cohort study Head or brain injuries and Alzheimer's disease: a nested case-control register study Association of mild traumatic brain injury with and without loss of consciousness with dementia in US military veterans Military-related risk factors in female veterans and risk of dementia Association between statin use and risk of dementia after a concussion Chronic traumatic encephalopathy -confusion and controversies Neurodegenerative disease mortality among former professional soccer players Association of ideal cardiovascular health with vascular brain injury and incident dementia Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study Association of midlife to latelife blood pressure patterns with incident dementia Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged ≥75 years: a randomized clinical trial Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial Prevention of cognitive impairment with intensive systolic blood pressure control Blood pressure and dementia: what the SPRINT-MIND trial adds and what we still need to know Diuretic antihypertensive drugs and incident dementia risk: a systematic review, meta-analysis and meta-regression of prospective studies Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies Calcium channel blocker use reduces incident dementia risk in elderly hypertensive patients: a meta-analysis of prospective studies An investigation of antihypertensive class, dementia, and cognitive decline: a metaanalysis Statins for the prevention of dementia Effect of aspirin on disability-free survival in the healthy elderly Risk factors associated with the onset and progression of Alzheimer's disease: a systematic review of the evidence Midlife physical activity, psychological distress, and dementia risk: the HUNT study Midlife cardiovascular fitness and dementia: a 44-year longitudinal population study in women Physical inactivity, cardiometabolic disease, and risk of dementia: an individualparticipant meta-analysis Association of leisure-time physical activity across the adult life course with all-cause and cause-specific mortality Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: a systematic review and metaanalysis Exercise training for preventing dementia, mild cognitive impairment, and clinically meaningful cognitive decline: a systematic review and meta-analysis Sex differences in exercise efficacy to improve cognition: a systematic review and meta-analysis of randomized controlled trials in older humans Risk reduction of cognitive decline and dementia: WHO guidelines. We evaluated new evidence on dementia risk in LMIC; risks and protective factors for dementia; detection of Alzheimer's disease; multimorbidity in dementia; and interventions for people affected by dementia.
- keywords: 0·5; 0·6; 0·7; 0·8; 1·2; activities; activity; adults; age; aged; ageing; agitation; aids; alcohol; alzheimer; amyloid; analysis; assessment; associated; association; baseline; better; biomarkers; blood; brain; burden; cardiovascular; care; carers; cause; cause dementia; changes; china; clinical; cognition; cognitive; cognitive decline; cognitive function; cognitive impairment; cohort; cohort study; commission; community; consumption; contact; control; costs; countries; course; covid-19; cross; data; death; decline; delirium; dementia; dementia dementia; dementia prevention; dementia risk; depression; diabetes; diagnosis; diet; different; difficult; disease; disease dementia; drinking; duration; early; education; effect; effectiveness; estimates; evidence; example; excessive; exercise; exists; exposure; family; figure; follow; function; future; general; global; group; harm; health; hearing; hic; high; higher; homes; hospital; hypertension; impact; impairment; important; incidence; incident; incident dementia; increase; individual; injury; intensive; intervention; later; level; life; life dementia; lifestyle; likely; living; lmic; longitudinal; loss; lower; management; mean; mechanisms; medical; memory; mental; meta; midlife; mild; mild cognitive; model; moderate; modifiable; modifiable risk; months; mortality; national; need; neurodegeneration; neuropsychiatric; new; non; normal; number; obesity; observational; older; older people; onset; outcomes; overall; paf; participants; pathology; patients; people; person; pet; physical; pollution; population; positive; possible; potential; pressure; prevalence; prevention; primary; prospective; psychological; quality; randomized; rates; rcts; reduced; reduction; related; relationship; research; reserve; residents; results; retirement; review; risk; risk factors; severe; severity; sex; significant; similar; single; sleep; small; smoking; social; specific; staff; standard; status; studies; study; support; symptoms; systematic; systematic review; systolic; tau; tbi; term; therapy; time; training; traumatic; treatment; trial; unclear; units; use; whitehall; women; worldwide; years
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- cord-269528-m8i1ss4w
- author: Poortmans, Philip M
- title: Cancer and COVID-19: what do we really know?
- date: 2020-05-29
- words: 741
- flesch: 36
- summary: International guidelines on radiation therapy for breast cancer during the COVID-19 Pandemic Recommendations for triage, prioritization and treatment of breast cancer patients during the COVID-19 pandemic Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists' perspective Cancer patient management during the COVID-19 pandemic COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study Do Patients with cancer have a poorer prognosis of COVID-19? The oncology community has suddenly needed to protect a population assumed to be vulnerable from a potentially fatal infection, without jeopardising cancer treatments.
- keywords: anticancer; cancer; care; cov-2; covid-19; data; days; disease; follow; mortality; pandemic; patients; sars; status; therapy; treatments
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- cord-269623-9pxdeva3
- author: Nicholson, Karl G
- title: Influenza
- date: 2003-11-22
- words: 9809
- flesch: 36
- summary: Of the three types of influenza viruses-A, B, and C-only types A and B cause widespread outbreaks. In southern China, influenza viruses circulate throughout the year.
- keywords: acute; admissions; adults; aged; amantadine; analysis; antibody; antigenic; antiviral; asthma; available; avian; avian influenza; beings; benefits; care; cases; cause; children; china; chronic; clinical; community; conventional; data; days; deaths; diagnosis; disease; drugs; effectiveness; efficacy; elderly; emergence; epidemics; evidence; excess; gene; global; h1n1; h1n2; h3n2; h5n1; h7n7; h9n2; haemagglutinin; healthy; high; hong; hospital; human; illness; inactivated; individuals; infected; infection; influenza; influenza vaccination; influenza vaccine; influenza viruses; inhibitor; intention; interpandemic; kong; laboratory; licensed; like; live; meta; molecular; mortality; neuraminidase; new; non; older; oseltamivir; outbreaks; pandemic; pathogenicity; patients; people; placebo; pneumonia; population; prevention; prophylaxis; protection; protein; randomised; rapid; rates; recombinant; resistance; respiratory; response; results; risk; safety; severe; strains; studies; study; subtypes; surveillance; symptoms; table; treatment; trials; vaccination; vaccines; virulence; virus; viruses; years; young; zanamivir
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- cord-269702-20sldbte
- author: Nkengasong, John N
- title: Response to the Ebola virus disease outbreak in the Democratic Republic of the Congo
- date: 2018-06-14
- words: 2452
- flesch: 44
- summary: key: cord-269702-20sldbte authors: Nkengasong, John N; Onyebujoh, Philip title: Response to the Ebola virus disease outbreak in the Democratic Republic of the Congo date: 2018-06-14 journal: Lancet DOI: 10.1016/s0140-6736(18)31326-6 sha: doc_id: 269702 cord_uid: 20sldbte nan The unfolding outbreak of Ebola virus disease in the Democratic Republic of the Congo (DRC) dominated discussions at last month's World Health Assembly (WHA) in Geneva, Switzerland. On May 8, 2018, the DRC Government declared an outbreak of Ebola virus disease, initially in a remote area of the Equateur Province (figure).
- keywords: aaa; abdominal; africa; aneurysm; aortic; bikoro; care; cases; cdc; centres; china; congo; control; democratic; disease; drc; ebola; ebola virus; financial; government; health; infarction; international; kinshasa; laboratory; mbandaka; myocardial; outbreak; partners; population; prevention; republic; response; screening; smoking; support; troponin; type; virus; virus disease; west; workers
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- cord-270858-ozvdz9ew
- author: Altmann, Daniel M
- title: What policy makers need to know about COVID-19 protective immunity
- date: 2020-04-27
- words: 1564
- flesch: 41
- summary: 13 Some of the uncertainty about COVID-19 protective immunity could be addressed by monitoring the frequency of reinfection with SARS-CoV-2. Specific T-lymphocyte immunity against Middle East respiratory syndrome coronavirus, however, can be detectable for 4 years, considerably longer than antibody responses.
- keywords: antibodies; antibody; candidate; cases; coronavirus; correlates; cov-2; covid-19; data; disease; herd; immune; immunity; infection; makers; need; people; policy; population; protection; responses; sars; seroprevalence; severe; studies; testing; vaccination; vaccines; virus
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- cord-270969-zb6ih5dl
- author: Chongsuvivatwong, Virasakdi
- title: Health and health-care systems in southeast Asia: diversity and transitions
- date: 2011-01-25
- words: 5894
- flesch: 42
- summary: In this first paper in the Lancet Series on health in southeast Asia, we present an overview of key demographic and epidemiological changes in the region, explore challenges facing health systems, and draw attention to the potential for regional collaboration in health. The diversity of geography and history, including social, cultural, and economic diff erences, have contributed to highly divergent health status and health systems across and within countries of southeast Asia.
- keywords: access; aff; ageing; analysis; asean; asia; cambodia; care; challenges; change; child; chronic; climate; collaboration; communicable; conditions; control; countries; coverage; crisis; data; death; demographic; development; diff; diseases; diverse; diversity; economic; eff; epidemiological; fertility; global; greater; growth; health; health care; health systems; high; higher; indonesia; infectious; issues; labour; laos; major; malaysia; medical; migration; mortality; myanmar; nancing; new; non; offi; pacifi; past; people; philippines; policy; political; population; private; programmes; public; rapid; rates; reduction; region; regional; res; risk; sector; services; signifi; singapore; social; southeast; southeast asia; systems; thailand; tobacco; trade; trends; use; vietnam; webappendix; world; years
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- cord-271528-ob4l0bcf
- author: Bar-Zeev, Naor
- title: COVID-19 vaccines: early success and remaining challenges
- date: 2020-09-04
- words: 1506
- flesch: 46
- summary: key: cord-271528-ob4l0bcf authors: Bar-Zeev, Naor; Inglesby, Tom title: COVID-19 vaccines: early success and remaining challenges date: 2020-09-04 journal: Lancet DOI: 10.1016/s0140-6736(20)31867-5 sha: doc_id: 271528 cord_uid: ob4l0bcf nan In The Lancet, Denis Y Logunov and colleagues from the N F Gamaleya Research Institute of Epidemiology and Microbiology in Russia present findings from two phase 1/2, non-randomised, open-label studies of a heterologous, replication-deficient, recombinant adenovirus vector-based vaccine in both frozen and lyophilised formulations. Showing safety will be crucial with COVID-19 vaccines, not only for vaccine acceptance but also for trust in vaccination broadly.
- keywords: adenovirus; adverse; colleagues; cov-2; covid-19; disease; dose; efficacy; events; formulations; groups; immunity; immunogenicity; logunov; neutralisation; participants; phase; randomised; risk; safety; sars; studies; study; trials; vaccine; vector
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- cord-272137-enfxk1ku
- author: Choo, Esther K
- title: COVID-19 fault lines
- date: 2020-04-23
- words: 857
- flesch: 65
- summary: No one would think to provide the luxury of sufficient space and staff to, say, enable the kind of social distancing space between occupants that is recommended in the midst of the coronavirus disease 2019 (COVID-19) pandemic. But as we scramble to distribute limited resources such as tests and hospital equipment andultimately-therapies and a vaccine, we must be careful to avoid reinforcing existing fault lines going forward.
- keywords: bowl; covid-19; disease; distancing; emergency; fault; home; homeless; hospital; lines; medicine; pandemic; plan; shelters; social; spread
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- cord-272147-itdx3wqi
- author: White, Alexandre I R
- title: Historical linkages: epidemic threat, economic risk, and xenophobia
- date: 2020-03-27
- words: 1832
- flesch: 45
- summary: While quarantine, cordon sanitaire, and other social distancing practices date back to 14th-century Europe and earlier, by the 19th century the spread of epidemic diseases emerged as a problem that required an international, coordinated response. When we think about the framing of disease threats, we must recognise that the history of international infectious disease control has largely been shaped by a distinctly European perspective, prioritising epidemic threats that arose from colonial (or now post-colonial) sites that threatened to spread disease and affect trade.
- keywords: administrators; asian; century; chinese; cholera; colonial; conventions; disease; economic; epidemic; europe; european; global; health; history; india; infectious; international; pandemic; particular; plague; quarantine; responses; risk; sanitary; spread; threat; trade; world; xenophobic
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- cord-274112-6t0wpiqy
- author: Webby, RJ
- title: Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines
- date: 2004-04-03
- words: 4214
- flesch: 41
- summary: Future influenza vaccines and the use of genetic recombinants Developing vaccines against pandemic influenza The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses Proteolytic cleavage of influenza virus hemagglutinins: primary structure of the connecting peptide between HA1 and HA2 determines proteolytic cleavability and pathogenicity of Avian influenza viruses Molecular analyses of the hemagglutinin genes of H5 influenza viruses: origin of a virulent turkey strain Rescue of influenza A virus from recombinant DNA A DNA transfection system for generation of influenza A virus from eight plasmids Generation of influenza A viruses entirely from cloned cDNAs Eight-plasmid system for rapid generation of influenza virus vaccines Plasmid-only rescue of influenza A virus vaccine candidates Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics Recombinant influenza A virus vaccines for the pathogenic human A/Hong Kong/97 (H5N1) viruses Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics Development of a Vero cellderived influenza whole virus vaccine Influvac: a safe Madin Darby Canine Kidney (MDCK) cell culturebased influenza vaccine Safety and immunogenicity of a trivalent, inactivated, mammalian cell culture-derived influenza vaccine in healthy adults, seniors, and children Generation of High-Yielding Influenza A Viruses in African Green Monkey Kidney (Vero) Cells by reverse genetics Avian influenza The agent must be handled only under conditions of at least biosafety level 3 (BSL3), and it can kill fertilised chicken eggs, the standard medium for the reassortment and Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines propagation of influenza virus before its inactivation and formulation for use in vaccines.
- keywords: alert; allantoic; assays; avian; beings; candidate; cells; chicken; cleavage; days; development; disease; eggs; ferrets; figure; future; genetics; global; h5n1; h5n1 influenza; h5n1 virus; haemagglutinin; high; hong; hong kong/213/03; human; infected; infection; influenza; influenza vaccine; isolated; kong/213/03; manufacture; mem; old; opti; outbreaks; pandemic; passages; pathogenicity; plasmid; pr8; production; rapid; reference; reference virus; rescue; respiratory; response; reverse; reverse genetics; seed; site; time; transfection; trypsin; usa; vaccine; vero; virus; viruses
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- cord-274313-mrvk9r4w
- author: Li, Hui
- title: SARS-CoV-2 and viral sepsis: observations and hypotheses
- date: 2020-04-17
- words: 2434
- flesch: 36
- summary: Diagnosis and treatment of novel coronavirus pneumonia in China A pathological report of three COVID-19 cases by minimally invasive autopsies A novel coronavirus from patients with pneumonia in China Detection of SARS-CoV-2 in different types of clinical specimens A pneumonia outbreak associated with a new coronavirus of probable bat origin Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. 8, 9 SARS-CoV-2 infectious virus particles have been isolated from respiratory samples, 10 as well as from faecal 11 and urine (Zhao J, Guangzhou Medical University, personal communication) specimens from COVID-19 patients, suggesting that multiple organ dysfunction in severe COVID-19 patients is at least partially caused by a direct attack from the virus.
- keywords: ace2; addition; alveolar; basic; blood; cells; china; clinical; coronavirus; cov-2; covid-19; cytokine; disease; dysfunction; high; immune; infection; influenza; injury; lung; lymphocytes; mechanism; multiple; novel; organs; outbreak; particles; patients; peripheral; pneumonia; receptor; research; respiratory; response; sars; science; sepsis; severe; storm; studies; viral
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- cord-275404-hv3y4x4g
- author: Zumla, Alimuddin
- title: Infection control and MERS-CoV in health-care workers
- date: 2014-05-20
- words: 1528
- flesch: 37
- summary: World Health Organization Guidelines for environmental infection control in health-care facilities. key: cord-275404-hv3y4x4g authors: Zumla, Alimuddin; Hui, David S title: Infection control and MERS-CoV in health-care workers date: 2014-05-20 journal: Lancet DOI: 10.1016/s0140-6736(14)60852-7 sha: doc_id: 275404 cord_uid: hv3y4x4g nan The recent exponential rise in the number of reported cases of Middle East respiratory syndrome coronavirus (MERS-CoV) is of major global concern.
- keywords: acute; aerosol; blood; care; cases; control; coronavirus; cov; data; east; health; hospital; hypertension; infection; mers; middle; outbreak; patients; precautions; pressure; prevention; respiratory; risk; sars; severe; syndrome; transmission; ventilation; workers
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- cord-277446-0e6akcjf
- author: Liu, Peilong
- title: China's distinctive engagement in global health
- date: 2014-08-28
- words: 6236
- flesch: 50
- summary: Figure 3 shows China health aid to Africa with countries shaded according to density of medical team coverage and demarcated by aided facilities and malaria control. Figure 4 shows four scatter-plots of China health aid and African trade.
- keywords: aff; africa; aid; air; america; analysis; approach; artemisinin; asia; assistance; barefoot; capacity; care; china; chinese; cial; commercial; common; construction; control; cooperation; council; countries; country; data; development; disease; distinctive; donor; drug; economic; education; eff; engagement; epidemic; facilities; foreign; foreign aid; global; global health; governance; government; health; health aid; human; important; income; infectious; infl; interest; international; japan; key; knowledge; largest; malaria; medical; medical teams; medicine; members; ministry; multilateral; new; offi; overseas; participation; people; policy; political; pollution; products; recipient; reports; republic; research; resources; risks; rst; sars; small; sources; state; strategy; students; support; system; teams; trade; traditional; uenza; universities; white; workers; world; year
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- cord-279575-sv1xhxb5
- author: Hogan, William
- title: The ongoing torture and medical neglect of Julian Assange
- date: 2020-06-25
- words: 3060
- flesch: 46
- summary: Since our previous letter, Mr Assange has been the subject of six legal hearings (24) (25) (26) (27) 25 March, 7 April, 27 April, 4 May, and 1 June), which form part of our detailed timeline of events provided (TABLE 2) . Throughout these and subsequent hearings, Mr Assange has been unable to engage in his own defence.
- keywords: act; application; assange; authorities; bail; belmarsh; convention; court; covid-19; date; day; enclosure; events; extradition; glass; hearing; human; ibahri; international; journalists; judge; julian; july; key; lawyers; medical; mr assange; new; prison; prisoners; proceedings; psychological; public; release; rights; risk; september; torture; treatment; video; videolink
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- cord-279681-ezu1j0tc
- author: Wang, Lin-Fa
- title: From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses
- date: 2020-02-11
- words: 1286
- flesch: 53
- summary: Third, a One Health approach 11 in EZV outbreak responses and control is vital. Second, clinicians and scientists have a crucial role in responding to such EZV outbreaks.
- keywords: aetiological; animal; china; chinese; clinicians; coronavirus; early; ezv; health; investigations; isolation; ncov; new; ngs; novel; outbreak; respiratory; response; sars; sequence; syndrome; team; virus; viruses; wuhan
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- cord-281397-w7ne9mj5
- author: Leverenz, David L
- title: Is the HScore useful in COVID-19?
- date: 2020-05-05
- words: 224
- flesch: 31
- summary: key: cord-281397-w7ne9mj5 authors: Leverenz, David L; Tarrant, Teresa K title: Is the HScore useful in COVID-19? date: 2020-05-05 journal: Lancet DOI: 10.1016/s0140-6736(20)31057-6 sha: doc_id: 281397 cord_uid: w7ne9mj5 nan In a review of 191 patients with COVID-19 admitted to hospital, 3 the IQR of ferritin concentrations at time of admission in non-survivors was 728·9-2000·0 ng/mL, and the median ferritin did not exceed 2000·0 ng/mL until 16 days after symptom onset, when most patients had experienced acute respiratory distress syndrome requiring intubation. Other HScore criteria such as hypertriglyceridaemia, splenomegaly, hepatomegaly, and bone marrow haemophagocytosis are not reported in most cohort studies of COVID-19.
- keywords: covid-19; hscore; patients; w7ne9mj5
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- cord-282411-n5xlpqms
- author: Wang, Huali
- title: Dementia care during COVID-19
- date: 2020-03-30
- words: 1189
- flesch: 48
- summary: Older people in many countries, unlike in China, tend to live alone or with their spouse, either at home or in nursing homes. To lessen the chance of infection among older people in nursing homes, more local authorities are banning visitors to nursing homes and longterm care facilities.
- keywords: alzheimer; care; carers; china; chinese; coronavirus; covid-19; dementia; disease; facilities; health; homes; infection; international; mental; nursing; older; pandemic; patients; pcr; people; residents; results; support
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- cord-282420-0fcyjw7l
- author: Lu, Cheng-wei
- title: 2019-nCoV transmission through the ocular surface must not be ignored
- date: 2020-02-06
- words: 310
- flesch: 49
- summary: The fact that exposed mucous membranes and unprotected eyes increased the risk of SARSCoV transmission 4 suggests that exposure of unprotected eyes to 2019nCoV could cause acute respiratory infection. Thus, Huang and colleagues 1 should have analysed conjunctival scrapings from both confirmed and suspected 2019nCoV cases during the onset of symptoms.
- keywords: 2019ncov; acute; eyes; infection; respiratory; unprotected; wang; wuhan
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- cord-283196-laerx0n2
- author: Bedford, Juliet
- title: Living with the COVID-19 pandemic: act now with the tools we have
- date: 2020-10-08
- words: 1696
- flesch: 30
- summary: COVID-19 vaccines, therapeutics, and diagnostics are important for the pandemic response, and if any of the COVID-19 vaccine candidates are shown to be safe and effective, they will probably be deployed before full approval through emergency use authorisations or other strategies. With current knowledge, even in the absence of COVID-19 vaccines or treatments and comprehensive knowledge of the immune response to SARS-CoV-2, countries can navigate pathways to reduced transmission, decreased severe illness and mortality, and less economic disruption in the short and longer term.
- keywords: approach; care; clinical; coronavirus; countries; cov-2; covid-19; disease; evidence; health; immune; infection; international; measures; outbreaks; pandemic; public; research; response; risk; sars; severe; strategies; term; testing; tests; therapeutics; transmission; travel; use; vaccines
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- cord-283744-qkvo6cji
- author: Marston, Cicely
- title: Community participation is crucial in a pandemic
- date: 2020-05-04
- words: 1212
- flesch: 39
- summary: key: cord-283744-qkvo6cji authors: Marston, Cicely; Renedo, Alicia; Miles, Sam title: Community participation is crucial in a pandemic date: 2020-05-04 journal: Lancet DOI: 10.1016/s0140-6736(20)31054-0 sha: doc_id: 283744 cord_uid: qkvo6cji nan Community participation is essential in the collective response to coronavirus disease 2019 (COVID-19), from compliance with lockdown, to the steps that need to be taken as countries ease restrictions, to community support through volunteering. 2 Global health guidelines already emphasise the importance of community participation.
- keywords: care; citizens; communities; community; compliance; coproduction; covid-19; crucial; different; diverse; engagement; groups; health; hiv; needs; pandemic; participation; policy; public; response; rights; services; social; spaces; stigma
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- cord-284711-l1za83w1
- author: Anand, Sudhir
- title: Human security and universal health insurance
- date: 2011-08-30
- words: 1231
- flesch: 42
- summary: key: cord-284711-l1za83w1 authors: Anand, Sudhir title: Human security and universal health insurance date: 2011-08-30 journal: Lancet DOI: 10.1016/s0140-6736(11)61148-3 sha: doc_id: 284711 cord_uid: l1za83w1 nan Human security is a multidimensional concept that has been a cornerstone of Japanese development cooperation for more than a decade. 1,2 Three distinct questions arise from the concept of human security.
- keywords: agency; asia; capability; care; central; comprehensive; concept; concern; contracts; countries; coverage; economic; health; human; ill; insurance; japan; life; patients; person; protection; question; risk; security; threshold; universal
- versions: original; plain text
- cord-288197-drto66xt
- author: Chen, Huijun
- title: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records
- date: 2020-02-12
- words: 3939
- flesch: 51
- summary: Considering that SARS-CoV-2 has up to 85% sequence similarity with SARS, [11] [12] [13] [14] although none of our patients developed severe pneumonia or died of COVID-19 infection, we should be alert to the possibility that the disease course and prognosis of COVID-19 pneumonia could follow the same trend as SARS in pregnant women. Answers to these questions are essential for formulating the principles of obstetric treatment for pregnant women with COVID-19 infection.
- keywords: amniotic; apgar; blood; caesarean; characteristics; chest; china; clinical; collection; cord; coronavirus; cov-2; covid-19; covid-19 pneumonia; data; evidence; fetal; findings; fluid; infection; intrauterine; laboratory; min; neonatal; neonate; novel; patients; pcr; pneumonia; pregnancy; pregnant; pregnant women; respiratory; samples; sars; score; section; severe; study; swab; symptoms; throat; transmission; trimester; vertical; women; wuhan
- versions: original; plain text
- cord-288591-upnqi1f7
- author: Platt, Lucy
- title: Sex workers must not be forgotten in the COVID-19 response
- date: 2020-05-15
- words: 1338
- flesch: 35
- summary: COVID-19 responses must uphold and protect the human rights of sex workers Associations between sex work laws and sex workers' health: a systematic review and meta-analysis of quantitative and qualitative studies HIV infection among female sex workers in concentrated and high prevalence epidemics: why a structural determinants framework is needed Refugee and migrant health in the COVID-19 response Regional updates COVID-19 migrant sex workers and sex worker responses. key: cord-288591-upnqi1f7 authors: Platt, Lucy; Elmes, Jocelyn; Stevenson, Luca; Holt, Victoria; Rolles, Stephen; Stuart, Rachel title: Sex workers must not be forgotten in the COVID-19 response date: 2020-05-15 journal: Lancet DOI: 10.1016/s0140-6736(20)31033-3 sha: doc_id: 288591 cord_uid: upnqi1f7 nan As countries maintain or adjust public health measures, emergency legislation, and economic policies in response to the COVID-19 pandemic, there is an urgent need to protect the rights of, and to support, the most vulnerable members of society.
- keywords: access; community; covid-19; distancing; drug; economic; health; hiv; housing; income; infection; marginalised; need; pandemic; physical; policies; populations; protection; response; rights; risk; schemes; services; sex; social; support; use; workers
- versions: original; plain text
- cord-289235-slkqu1pt
- author: Carrabba, Giorgio
- title: Neurosurgery in an infant with COVID-19
- date: 2020-04-22
- words: 491
- flesch: 34
- summary: To our knowledge, no reports exist regarding the risk of general anaesthesia in infants with COVID-19. This case might reflect a general observation of relative resistance of babies and children to 4 suggesting the possibility that paucisymptomatic infants with COVID-19 can undergo major surgical procedures without additional morbidity.
- keywords: anaesthesia; baby; case; coronavirus; covid-19; general; infants; negative; neurosurgical; patients; respiratory; shunt; surgery
- versions: original; plain text
- cord-290068-s1gdbsfx
- author: Hon, KLE
- title: Clinical presentations and outcome of severe acute respiratory syndrome in children
- date: 2003-05-17
- words: 1902
- flesch: 52
- summary: All paediatric patients had clinically important lymphopenia, 3 Clinical features and treatment outcomes among SARS children children. We adopted a treatment regimen of ribavirin and steroids similar to that used in adult SARS patients.
- keywords: acute; adults; chemotherapy; chest; children; clinical; contact; days; fever; gabapentin; high; hong; kong; lymphopenia; nausea; oral; oxygen; patients; respiratory; ribavirin; sars; severe; syndrome; teenagers; treatment; younger
- versions: original; plain text
- cord-290983-p3vfo3ne
- author: Chan, EYY
- title: Public-health risks of melamine in milk products
- date: 2008-10-23
- words: 1262
- flesch: 54
- summary: 10 Unfortunately, melamine contamination is not the fi rst instance of unsafe milk formula in China. Chinese people have only recently started to appreciate milk products and many producers are small farmers, under pressure to maximise milk yield in the face of rising grain prices.
- keywords: aff; baby; cancer; children; china; chinese; concentration; contamination; copd; food; formula; government; health; infant; lung; melamine; milk; need; products; public; response; risk; sept; smoking; tuberculosis; use; years
- versions: original; plain text
- cord-291038-n8bk541m
- author: Bhala, Neeraj
- title: Sharpening the global focus on ethnicity and race in the time of COVID-19
- date: 2020-05-10
- words: 1681
- flesch: 42
- summary: For comparison, the 2011 census shows that ethnic minority groups made up about 14% of the UK population. Additionally, National Health Service (NHS) health-care staff from ethnic minority groups seem to have died in disproportionate numbers from COVID-19, even when accounting for the high proportion of people from these groups who are employed in the NHS and work on the front line.
- keywords: african; age; american; black; care; covid-19; data; deaths; disease; disparities; ethnic; ethnicity; factors; focus; groups; health; infections; minorities; minority; national; outcomes; people; populations; public; racial; relevant; risk; social; usa; vitamin; white
- versions: original; plain text
- cord-291315-y40s45iv
- author: Logunov, Denis Y
- title: Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia
- date: 2020-09-04
- words: 5736
- flesch: 45
- summary: Thus, the presence of a pre-existing immune response to the components of vaccine vectors rAd26 and rAd5 does not affect the titre of RBD-specific antibodies in the serum of participants. [30] The incidence of adverse events in our studies was slightly lower than in other work; a comparative clinical study with other vaccines is needed to confirm these findings.
- keywords: adenovirus; adverse; antibodies; antibody; antigen; aug; boost; cell; cellular; clinical; components; convalescent; coronavirus; correlation; cov-2; covid-19; data; days; dose; events; formation; formulations; frozen; gam; gene; glycoprotein; healthy; heterologous; humoral; immune; immunity; immunogenicity; infection; mers; neutralising; non; open; participants; people; phase; plasma; prime; rad26; rad5; randomised; rbd; receptor; recombinant; report; research; respiratory; responses; russia; safety; sars; specific; studies; study; syndrome; test; titres; trial; vaccination; vaccine; vector; viral; volunteers
- versions: original; plain text
- cord-292629-5kh46tks
- author: Divala, Titus
- title: Africa faces difficult choices in responding to COVID-19
- date: 2020-05-12
- words: 475
- flesch: 45
- summary: We estimate that in the UK, having COVID-19 confers risk of death equivalent to approximately 12 months of background mortality risk, averaged across all age groups. Without a context-specific, ethical approach to physical distancing, unintended harms from stringent lockdown could pose more harm than the direct effects of COVID-19 itself.
- keywords: africa; age; approach; background; covid-19; health; lockdown; malawi; mortality; physical; risk
- versions: original; plain text
- cord-293543-87ulnpdm
- author: Shalhoub, Sarah
- title: Interferon beta-1b for COVID-19
- date: 2020-05-10
- words: 958
- flesch: 43
- summary: World Health Organization Evaluation of antiviral therapies for coronavirus disease 2019 (COVID-19) pneumonia in Shanghai Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China Ribavirin and interferon therapy for critically ill patients with Middle East respiratory syndrome: a multicenter observational study Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Weak induction of interferon expression by SARS-CoV-2 supports clinical trials of interferon lambda SARS-CoV-2 sensitive to type I interferon pretreatment Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study 5,6 SARS-CoV-2 triggered lower type I interferon responses than SARS-CoV in an ex-vivo study in human lung tissue 7 and was found to be more susceptible to type I interferons than SARS-CoV. 8 In The Lancet, Ivan Fan-Ngai Hung and colleagues 9 present the results of an open-label, randomised, phase 2 trial that examined the effect of a triple combination regimen of interferon beta-1b 8 million international units (0·25 mg) on alternate days, lopinavir 400 mg plus ritonavir 100 mg every 12 h, and ribavirin 400 mg every 12 h, compared with lopinavir 400 mg plus ritonavir 100 mg every 12 h alone.
- keywords: beta-1b; combination; cov-2; covid-19; days; group; interferon; lopinavir; patients; respiratory; ritonavir; sars; severe; studies; study; treatment
- versions: original; plain text
- cord-295800-w0dup04b
- author: So, Loletta K-Y
- title: Development of a standard treatment protocol for severe acute respiratory syndrome
- date: 2003-05-10
- words: 2402
- flesch: 42
- summary: In this emerging disease that frequently has rapid deterioration, the inclusion of control patients was not possible or ethical. Staff washed hands with antiseptic rubs after every contact with patients or contaminated objects and after taking off protective garments.
- keywords: acute; case; chest; clinical; combination; daily; days; disease; disorder; dose; gata1; laboratory; lau; leukaemia; march; mechanical; megakaryoblastic; methylprednisolone; mutations; myeloid; oxygen; patients; probable; protocol; pulsed; rapid; respiratory; ribavirin; sars; series; severe; standard; step; syndrome; transient; treatment; ventilation; viral
- versions: original; plain text
- cord-295971-jtv1jj2z
- author: Cho, Sun Young
- title: MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study
- date: 2016-07-09
- words: 4639
- flesch: 52
- summary: The emergency room has its own radiology suite for emergency room patients only. Patients' demographic information, underlying disease, dates of emergency room visit, duration of stay with exact arrival and departure times, and location within the emergency room were collected.
- keywords: attack; care; cases; center; confi; contacts; control; coronavirus; cov; cov infection; data; disease; east; emergency; emergency room; exposure; group; gure; health; hospital; identifi; iii; incubation; infection; korea; large; manuscript; median; medical; mers; middle; outbreak; patient; period; potential; rates; respiratory; risk; rmed; room; samsung; single; south; study; syndrome; time; transmission; visitors; workers; zone
- versions: original; plain text
- cord-296863-xu0h92ac
- author: Berlinguer, Giovanni
- title: Bioethics, health, and inequality
- date: 2004-09-17
- words: 4326
- flesch: 44
- summary: The future of health, health policies, and health equity is strictly connected to the resolution of these contradictions. Very few raised two general questions: what else can we expect for world health from potential climate change, and what should we do about present and future risks? At the end of the 1990s, new political and moral trends began to emerge in the world, and new emphasis was given to health and equity in health.
- keywords: aids; bioethics; body; care; cells; cloning; commission; convention; countries; cultural; death; debate; dignity; discrimination; equity; europe; freedom; future; general; genetic; health; history; human; ibc; idea; individuals; interests; international; journal; legal; life; medical; moral; nations; new; non; organs; parts; past; people; person; policies; political; poor; principles; public; question; reasons; report; research; resources; rights; science; scientific; security; selection; sen; services; sex; similar; slavery; social; society; time; unesco; universal; women; world
- versions: original; plain text
- cord-299375-ve4lag21
- author: Yang, Yichang
- title: Use of herbal drugs to treat COVID-19 should be with caution
- date: 2020-05-15
- words: 929
- flesch: 41
- summary: key: cord-299375-ve4lag21 authors: Yang, Yichang title: Use of herbal drugs to treat COVID-19 should be with caution date: 2020-05-15 journal: Lancet DOI: 10.1016/s0140-6736(20)31143-0 sha: doc_id: 299375 cord_uid: ve4lag21 nan On April 14, 2020, a Chinese official announced at a press conference that indications of three patent herbal drugs were approved to be expanded to include COVID-19 symptoms. So far, no high-quality, rigorously peerreviewed clinical trials of herbal drugs have been reported in internationally recognised journals.
- keywords: chinese; clinical; conditions; covid-19; diagnosis; drugs; efficacy; evidence; herbal; lianhuaqingwen; medicine; patent; safety; severe; symptoms; traditional; treatment; trials
- versions: original; plain text
- cord-299440-y6o5e2k5
- author: Elachola, Habida
- title: A crucial time for public health preparedness: Zika virus and the 2016 Olympics, Umrah, and Hajj
- date: 2016-02-07
- words: 1974
- flesch: 39
- summary: Although both countries may have robust vector control eff orts, no single approach is adequate to prevent mosquito bites and non-vector modes of Zika virus transmission; a combination of measures is needed at personal, community, and policy levels. Additionally, by training athletic coaches on prevention of Zika virus transmission, their frequent contacts with athletes can be used to remind athletes about the need for compliance with public health advisories.
- keywords: alcoholic; arabia; brazil; control; countries; dengue; disease; eff; fatty; gilead; h1n1; hajj; health; hong; international; kong; liver; long; mass; mosquito; non; nonalcoholic; olympics; outcomes; patients; personal; pilgrims; prevention; public; saudi; sexual; spread; steatohepatitis; study; surrogate; term; time; transmission; treatment; umrah; virus; zika
- versions: original; plain text
- cord-299627-nu4typ7j
- author: Acuin, Cecilia S
- title: Maternal, neonatal, and child health in southeast Asia: towards greater regional collaboration
- date: 2011-01-25
- words: 6811
- flesch: 42
- summary: Plotting maternal mortality reductions against gross national income per capita (webappendix p 9) indicates that, although countries with high maternal mortality achieved reductions in mortality as their gross national income per capita increased, some of the most notable declines in mortality took place earlier than the rapid rise in gross national income. 21, 22 We fi tted data to a quadratic equation: log 10 MMR or log 10 NMR=Intercept+linear eff ect of year +quadratic eff ect of year and to a linear equation: log 10 MMR or log 10 NMR=Intercept+linear eff ect of year to establish whether declines in maternal mortality could be attributed to programme changes or temporal trends, where MMR is the maternal mortality ratio and NMR is the neonatal mortality rate.
- keywords: access; analysis; asean; asia; basic; birth; brunei; cambodia; care; case; causes; child; child deaths; child health; child mortality; countries; country; coverage; data; deaths; decline; demographic; developed; development; diff; diseases; economic; ect; eff; estimates; gross; health; high; income; indonesia; infant; interventions; key; laos; levels; list; lives; malaysia; maternal; maternal deaths; maternal mortality; mortality; myanmar; national; nations; need; neonatal; neonatal mortality; obstetric; patterns; philippines; policy; population; potential; programme; progress; rates; reductions; region; regional; rural; singapore; southeast; subgroups; substantial; support; surveys; survival; system; thailand; time; trends; universal; vietnam; webappendix; year
- versions: original; plain text
- cord-300149-djclli8n
- author: Ruan, Yijun
- title: Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection
- date: 2003-05-24
- words: 4358
- flesch: 47
- summary: We compared sequence data generated from the library with human, mouse, and viral genome databases managed at the US National Center for Biotechnology The basic local alignment search tool is a system for searching similar sequences against all available sequence databases irrespective of whether the query is DNA or protein sequences. Associations between the members of the coronaviridae family to the SARS virus were assessed by comparing overlapping fragments of the SIN2500 genomic sequence against a database of coronavirus sequences.
- keywords: acute; addition; aminoacid; analysis; available; base; case; cell; common; contact; coronavirus; cov; data; deletion; differences; distinct; figure; genetic; genome; genotype; glycoprotein; hong; host; hotel; index; infection; isolates; kong; loci; major; methods; multiple; mutations; new; nucleotide; patients; pcr; phylogenetic; polymerase; polymorphisms; position; primary; protein; putative; region; respiratory; rna; samples; sars; sars virus; secondary; sequence; severe; sin2500; sin2748; singapore; specific; spike; strain; syndrome; usa; variant; variations; vero; viral; viruses
- versions: original; plain text
- cord-300236-mon1loph
- author: Williams, Bryan
- title: Hypertension, renin–angiotensin–aldosterone system inhibition, and COVID-19
- date: 2020-05-14
- words: 1241
- flesch: 28
- summary: Nor does evidence exist to suggest that, once infected, the risk of admission to hospital due to COVID-19, progression to more severe complications, or death is increased with RAAS inhibitor use compared with treatment with other antihypertensive drugs. These factors have fuelled speculation that use of RAAS inhibitors, particularly ACE inhibitors or angiotensin-receptor blockers, could lead to increased expression of ACE2 in the respiratory tract, thereby increasing the risk of both becoming infected and developing severe life-threatening complications due to COVID-19.
- keywords: ace; angiotensin; antihypertensive; blockers; covid-19; data; drugs; hospital; hypertension; inhibitors; patients; raas; receptor; renin; risk; severe; studies; use
- versions: original; plain text
- cord-302485-hhsa76k8
- author: Wu, Yuntao
- title: SARS-CoV-2 is an appropriate name for the new coronavirus
- date: 2020-03-06
- words: 854
- flesch: 47
- summary: The authors argued that the use of SARS in the virus name could confuse the public about the disease that it causes; in addition, they noted that the name SARS-CoV-2 is not consistent with the disease name chosen by WHO, coronavirus disease 2019. The use of SARS in naming SARS-CoV-2 does not derive from the name of the SARS disease but is a natural extension of the taxonomic practice for viruses in the SARS species.
- keywords: authors; committee; coronavirus; cov-2; disease; group; new; sars; scientific; species; study; taxonomy; viral; viruses
- versions: original; plain text
- cord-303173-q88zdf03
- author: Panchaud, Alice
- title: An international registry for emergent pathogens and pregnancy
- date: 2020-04-27
- words: 532
- flesch: 23
- summary: For the ongoing SARS-CoV-2 pandemic, we hypothesise that the collected data will allow researchers and health-care professionals to better characterise the disease course and spectrum, quantitatively estimate associated risks, and identify specific risk factors that can be used to define screening strategies in pregnant women and adequate prevention meas ures, and to direct specific and early clinical management of women and fetuses at risk. The feasibility of this global responsive and customisable structure for future emergent pathogens is supported by the strong platform of well established collaborations with 198 antenatal clinics from 23 countries in Africa, Asia, Europe, Oceania, and the Americas (figure).
- keywords: acute; clinical; coronavirus; data; emergent; future; international; pathogens; pregnancy; pregnant; registry; sars; women
- versions: original; plain text
- cord-303208-4bui0ioe
- author: Jarlais, Don C Des
- title: Increasing HIV prevention and care for injecting drug users
- date: 2010-02-26
- words: 1341
- flesch: 49
- summary: key: cord-303208-4bui0ioe authors: Jarlais, Don C Des; Arasteh, Kamyar; Gwadz, Marya title: Increasing HIV prevention and care for injecting drug users date: 2010-02-26 journal: Lancet DOI: 10.1016/s0140-6736(10)60314-5 sha: doc_id: 303208 cord_uid: 4bui0ioe nan In The Lancet today, Bradley Mathers and colleagues 1 make a heroic eff ort-in fact, a systematic review-to document the coverage (services provided per individual in need of services) for HIV prevention and care for injecting drug users (IDUs) throughout the world. Were the vaccine to mostly go to girls in states such as Rhode Island rather than those in Mississippi, such a pattern would not only fail to match Contingency management and relapse prevention as stimulant abuse treatment interventions Syringe exchange, injecting and intranasal drug use Choices, values and frames Contributions of behavioural decision theory to research in political science Community attitudes toward HIV prevention for injection drug users: fi ndings from a cross-border project in southern China and northern Vietnam Human rights and HIV prevention among drug users
- keywords: aids; behaviour; cancer; cervical; change; diff; drug; ective; eff; health; hiv; idus; interventions; makers; policy; prevention; programmes; risk; services; system; theories; theory; users
- versions: original; plain text
- cord-305906-a2srympy
- author: Haines, Andy
- title: National UK programme of community health workers for COVID-19 response
- date: 2020-03-24
- words: 2014
- flesch: 44
- summary: We propose a largescale emergency programme to train community health workers (CHWs) to support people in their homes, initially the most vulnerable but with potential to provide a longterm model of care in the UK. In a time of fear, isolation, and growing health inequalities, 10 use of CHWs for the COVID19 response would boost social coherence and fill gaps that have begun to emerge between health and social care and inperson and virtual access to health care.
- keywords: authors; brazil; care; children; chws; clinical; community; consept; convulsive; covid19; eclipse; emergency; epilepticus; esett; health; levetiracetam; management; medical; mental; need; people; phenytoin; potential; primary; programme; public; research; seizure; social; status; support; team; training; trial; valproate; vulnerable; workers; workforce; years
- versions: original; plain text
- cord-306583-ttz6oszw
- author: Jordana, Jacint
- title: Where are the ECDC and the EU-wide responses in the COVID-19 pandemic?
- date: 2020-05-13
- words: 813
- flesch: 51
- summary: In our research on the role of EU agencies in crisis episodes, we described how the low cooperation in public health issues within Europe severely hampered the involvement of the ECDC in the European response to the 2014 Ebola outbreak. The ECDC was established within a context that involved inconsistent national laws on pandemic planning across the EU member states, which already had their own institutes and agencies of public health.
- keywords: commission; covid-19; crisis; ecdc; european; health; march; member; national; pandemic; public; response; role; states
- versions: original; plain text
- cord-307622-r23eebet
- author: Kass, David A
- title: Obesity could shift severe COVID-19 disease to younger ages
- date: 2020-05-04
- words: 637
- flesch: 49
- summary: key: cord-307622-r23eebet authors: Kass, David A; Duggal, Priya; Cingolani, Oscar title: Obesity could shift severe COVID-19 disease to younger ages date: 2020-05-04 journal: Lancet DOI: 10.1016/s0140-6736(20)31024-2 sha: doc_id: 307622 cord_uid: r23eebet nan Obesity could shift severe COVID-19 disease to younger ages C o r o n a v Public messaging to younger adults, reducing the threshold for virus testing in obese individuals, and maintaining greater vigilance for this at-risk population should reduce the prevalence of severe COVID-19 disease.
- keywords: bmi; china; covid-19; disease; icu; individuals; obesity; patients; prevalence; risk; severe; similar; university; younger
- versions: original; plain text
- cord-307756-5etje6qs
- author: Dickens, Borame L
- title: Institutional, not home-based, isolation could contain the COVID-19 outbreak
- date: 2020-04-29
- words: 902
- flesch: 37
- summary: 8 Home-based isolation, which is reliant on personal In the absence of vaccines, non-pharmaceutical interventions such as physical distancing, intensive contact tracing, and case isolation remain frontline measures in controlling the spread of severe acute respiratory syndrome coronavirus 2. 1 In Wuhan, China, these measures were implemented alongside city lockdown, mass quarantine, and school closure during the coronavirus disease 2019 (COVID-19) outbreak in January and February, 2020. We modelled and compared two types of isolation measures: institution-based isolation and home-based isolation.
- keywords: assumed; cases; community; contact; covid-19; epidemic; home; household; infections; isolation; measures; number; outbreak; public; reduction; self; transmission; wuhan
- versions: original; plain text
- cord-307857-1xj0ys7c
- author: Headey, Derek
- title: Impacts of COVID-19 on childhood malnutrition and nutrition-related mortality
- date: 2020-07-27
- words: 1229
- flesch: 39
- summary: Our projections emphasise the crucial need for the actions to protect child nutrition that are urged by the UN leaders in the accompanying Comment. Of particular concern is an expected increase in child malnutrition, including wasting, due to steep declines in household incomes, changes in the availability and affordability of nutritious foods, and interruptions to health, nutrition, and social protection services.
- keywords: child; children; covid-19; economic; estimated; expected; food; gni; health; impacts; income; increase; lmics; malnutrition; maternal; mortality; nutrition; pandemic; projections; services; systems; wasting; years
- versions: original; plain text
- cord-309242-ilsupfl8
- author: Schuchat, Anne
- title: Global health and the US Centers for Disease Control and Prevention
- date: 2014-07-02
- words: 2887
- flesch: 42
- summary: The world is more interconnected than ever, and weak links in public health capacity anywhere can have profound eff ects at distant locations. CDC's global health strategy aims to: achieve optimum health eff ects; strengthen global health capacity; improve global health security; and strengthen the organisation's capacity.
- keywords: aids; approach; art; avian; capacity; cdc; centers; child; china; cholera; control; countries; detection; disease; earthquake; eff; epidemic; global; h5n1; h7n9; haiti; health; hiv; human; infected; infection; infl; infl uenza; local; ministries; mother; national; novel; partners; pepfar; pregnant; prevention; programmes; public; response; surveillance; testing; threats; transmission; treatment; uenza; usa; virus; women; years
- versions: original; plain text
- cord-310197-gwhb2e6q
- author: Khan, Ali S
- title: Health security in 2014: building on preparedness knowledge for emerging health threats
- date: 2014-07-02
- words: 3181
- flesch: 39
- summary: In Boston, the city's public health commission oversees citywide emergency response, requiring close integration of emergency response and public health. Other priorities include embracing new technology for disease monitoring and real-time information sharing; improving the evidence base; expanding preparedness principles to include climate disruption; and encouraging even more cross-sector integration between public health, health care, emergency management, and, especially, the private sector.
- keywords: advances; agents; approach; biological; boston; capabilities; capacity; care; chemical; coalitions; community; countermeasures; department; development; digital; disasters; eff; emergency; event; federal; government; h7n9; health; hhs; human; infl; information; laboratories; laboratory; local; management; medical; national; needs; new; orts; people; populations; preparedness; products; programme; public; public health; resilient; response; security; services; sharing; sns; state; support; system; teams; threats; uenza; usa; work
- versions: original; plain text
- cord-311887-e8p6wnil
- author: Okano, Justin T
- title: Preventing major outbreaks of COVID-19 in jails
- date: 2020-04-29
- words: 187
- flesch: 47
- summary: The Centre for Evidence-Based Medicine Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2) The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application Los Angeles County Jail system by the numbers. Los Angeles Almanac
- keywords: covid-19; expression; infected; inmate
- versions: original; plain text
- cord-312784-ykko0al5
- author: Takian, Amirhossein
- title: COVID-19 battle during the toughest sanctions against Iran
- date: 2020-03-18
- words: 1299
- flesch: 45
- summary: However, we request that the government urgently and openly shares the scientific evidence, data, and models it is using to inform current decision making related to COVID-19 public health interventions within the next 72 h and then at regular intervals thereafter. Vol 395 March 28, 2020 of the disease and evidence pertaining to effective public health interventions is increasingly available.
- keywords: community; coronavirus; countries; country; covid-19; disease; distancing; epidemic; evidence; government; health; iran; iranian; medical; outbreak; pandemic; public; response; sanctions; scientific; social; time
- versions: original; plain text
- cord-313028-0nhgxoim
- author: Huang, Chaolin
- title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- date: 2020-01-24
- words: 4834
- flesch: 46
- summary: KDIGO clinical practice guideline for acute kidney injury CDC definitions for nosocomial infections Association between cardiac injury and mortality in hospitalized patients infected with avian influenza A (H7N9) virus Coronaviruses post-SARS: update on replication and pathogenesis A major outbreak of severe acute respiratory syndrome in Hong Kong Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques SARS: systematic review of treatment effects Corticosteroids as adjunctive therapy in the treatment of influenza Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Origin and evolution of pathogenic coronaviruses Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting We acknowledge all health-care workers involved in the diagnosis and treatment of patients in Wuhan; we thank the Chinese National Health Commission for coordinating data collection for patients with 2019-nCoV infection; we thank WHO and the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) for sharing data collection templates publicly on the website; and we thank Prof Chen Wang and Prof George F Gao for guidance in study design and interpretation of results. Plasma levels of IL5, IL12p70, IL15, Eotaxin, and RANTES were similar between healthy adults and patients infected with 2019-nCoV. Further comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNFα were higher in ICU patients than non-ICU patients.
- keywords: acute; admission; available; care; cases; cause; characteristics; chest; china; clinical; cohort; collection; commission; coronavirus; corticosteroids; cytokines; data; disease; east; epidemiological; evidence; exposure; features; fever; findings; health; high; hospital; human; icu; icu patients; illness; infection; injury; ip10; iqr; jan; laboratory; lopinavir; market; mcp1; median; mers; middle; ncov; ncov infection; non; novel; onset; outcomes; patients; pcr; plasma; pneumonia; real; report; respiratory; ritonavir; sars; severe; study; symptoms; syndrome; time; tnfα; tract; treatment; viral; wuhan; years
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- cord-313316-l147b7jk
- author: Freudenthal, Bernard
- title: Misuse of SARS-CoV-2 testing in symptomatic health-care staff in the UK
- date: 2020-10-22
- words: 1111
- flesch: 52
- summary: UK Covid-19 testing expanded to police, fire service and judiciary Laboratory testing for coronavirus disease (COVID-19) in suspected human cases Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? Arguments against mass testing approaches previously have suggested a lack of resources might make this ineffective.
- keywords: approach; asymptomatic; care; cases; coronavirus; cov-2; covid-19; hcws; health; lateral; leonardo; results; sars; screening; single; studies; testing; transmission; ventricles; workers
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- cord-313845-757yiqlg
- author: Kirschenbaum, Daniel
- title: Inflammatory olfactory neuropathy in two patients with COVID-19
- date: 2020-07-10
- words: 573
- flesch: 42
- summary: We report two cases of olfactory neuropathy diagnosed at autopsy in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. key: cord-313845-757yiqlg authors: Kirschenbaum, Daniel; Imbach, Lukas L; Ulrich, Silvia; Rushing, Elisabeth J; Keller, Emanuela; Reimann, Regina R; Frauenknecht, Katrin B M; Lichtblau, Mona; Witt, Martin; Hummel, Thomas; Steiger, Peter; Aguzzi, Adriano; Frontzek, Karl title: Inflammatory olfactory neuropathy in two patients with COVID-19 date: 2020-07-10 journal: Lancet DOI: 10.1016/s0140-6736(20)31525-7 sha: doc_id: 313845 cord_uid: 757yiqlg nan
- keywords: anosmia; cells; cov-2; covid-19; damage; epithelium; infiltrates; inflammatory; neuropathy; olfactory; patient; positive; sars; system; viral
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- cord-314278-ea73au8c
- author: Gostin, Lawrence O
- title: The International Health Regulations 10 years on: the governing framework for global health security
- date: 2015-11-25
- words: 2333
- flesch: 32
- summary: State Parties widely disregarded WHO's temporary recommendations; 7, 8 however, in 2011, the Review Committee on International Health Regulations functioning during the H1N1 infl uence pandemic cautioned, The world is ill-prepared to respond to a severe infl uenza pandemic. Yet, a crisis of confi dence in the Regulations exists, with the Review Committee on International Health Regulations functioning during Ebola currently deliberating.
- keywords: annex; assembly; assessment; capacities; cation; committee; concern; core; decision; declaration; director; ebola; emergency; functioning; general; global; h1n1; health; help; human; infl; interim; international; pandemic; panel; parties; public; recommendations; reforms; regulations; report; reporting; restrictions; review; security; states; temporary; trade; transparency; world
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- cord-314579-4nc4d05v
- author: Aylward, R Bruce
- title: Global health goals: lessons from the worldwide effort to eradicate poliomyelitis
- date: 2003-09-13
- words: 4750
- flesch: 37
- summary: The cost-effectiveness of global poliomyelitis eradication was reassessed for 2001-2040 to analyse the potential effects of poliomyelitis immunisation policies that might be adopted after worldwide certification of eradication. Progress towards global poliomyelitis eradication Expanded Programme on Immunization.
- keywords: africa; analysis; areas; assembly; benefits; capacity; cases; children; community; control; costs; countries; country; decision; development; disease; economic; effort; endemic; eradication; eradication initiative; financial; financing; geneva; global; global health; goals; health; health goals; health systems; immunisation; implementation; income; india; initiative; international; lessons; nids; organization; partnership; polio eradication; poliomyelitis; poliomyelitis eradication; poliovirus; political; programme; progress; public; resources; services; strategies; strategy; substantial; sufficient; surveillance; systems; transmission; vaccine; world; world health; worldwide; year
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- cord-316566-5iqtj3db
- author: Elachola, Habida
- title: Oil prices, climate change—health challenges in Saudi Arabia
- date: 2016-01-27
- words: 1733
- flesch: 45
- summary: Saudi nationals (and pilgrims coming to Mecca for the Hajj) are entitled to free health care and the government accounted for 66% of health care spending in 2012 (about 5% of GDP). key: cord-316566-5iqtj3db authors: Elachola, Habida; Memish, Ziad A title: Oil prices, climate change—health challenges in Saudi Arabia date: 2016-01-27 journal: Lancet DOI: 10.1016/s0140-6736(16)00203-8 sha: doc_id: 316566 cord_uid: 5iqtj3db nan foods, such as sugar-sweetened beverages and energydense, nutrient-poor foods, in the school environment; informed nutrition education as part of the core curriculum; and ensuring levels of physical activity for all children according to WHO recommendations.
- keywords: approaches; arabia; beverages; care; children; control; countries; country; crisis; disease; echo; economic; ects; eff; factors; foods; health; high; income; increase; kingdom; marketing; ministry; mortality; population; prevention; promotion; recession; recommendations; risk; saudi; sector; services; uptake; workforce
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- cord-317126-j3o9cfkv
- author: Wang, Jigang
- title: Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic
- date: 2020-03-17
- words: 1238
- flesch: 46
- summary: 2 Africa needs to be prepared to deal with COVID-19, given the infectious potential of the disease and its capacity to undermine malaria control efforts. The emergence of Ebola in malaria-endemic countries, including Guinea, Liberia, and Sierra Leone, led to a public health emergency and dealt a heavy blow to malaria control efforts.
- keywords: africa; care; cases; china; control; countries; covid-19; disease; ebola; efforts; endemic; facilities; guinea; health; leone; malaria; management; measures; outbreak; regions; sierra; virus
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- cord-318858-x8p0n6r3
- author: Hope, Michael D
- title: A role for CT in COVID-19? What data really tell us so far
- date: 2020-03-27
- words: 1398
- flesch: 53
- summary: They found that 97% of cases with RT-PCR-confirmed diagnoses had CT findings of pneumonia, and conclude, CT imaging has high sensitivity for diagnosis of COVID-19. We urge caution and encourage using published guidelines 3 regarding use of CT imaging.
- keywords: cases; china; coronavirus; countries; covid-19; dementia; diagnosis; disease; findings; global; health; high; homes; imaging; infection; nursing; older; pandemic; patients; pcr; people; respiratory; results; syndrome
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- cord-318933-09ym98hx
- author: Betsch, Cornelia
- title: Monitoring behavioural insights related to COVID-19
- date: 2020-04-02
- words: 1548
- flesch: 36
- summary: Although we have already acknowledged the need to balance these two considerations in order to maintain public understanding and trust, we do not accept that conflict is inevitable as our approach requires all Vaccination and trusthow concerns arise and the role of communication in mitigating crises Risk communication for public health emergencies Communicating risk in public health emergencies: a WHO guideline for emergency risk communication (ERC) policy and practice Risk perception and self-protective behavior Pandemic public health paradox: time series analysis of the 2009/10 Influenza A/H1N1 epidemiology, media attention, risk perception and public reactions in 5 European countries Public perceptions, anxiety, and behaviour change in relation to the swine flu outbreak: cross sectional telephone survey Crisis and emergency risk communication as an integrative model COVID-19 Snapshot MOnitoring (COSMO): monitoring knowledge, risk perceptions, preventive behaviours, and public trust in the current coronavirus outbreak AZ is co-principal investigator of the Pan-African Network on Emerging and Re-Emerging Infections and is in receipt of a UK National Institutes of Health Research Senior Investigator Award. Preventing global spread of infectious diseases from mass gathering events and protecting global health security require public health decisions based on evidence and an agreed rational framework for decision making.
- keywords: analysis; appropriate; assessment; available; behaviour; communication; countries; covid-19; crisis; data; decision; effective; evidence; gathering; health; insights; knowledge; mass; measures; mers; need; outbreak; pandemic; perceptions; public; response; risk; time; trust
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- cord-320530-5xltmc65
- author: Bozorgmehr, Kayvan
- title: Power of and power over COVID-19 response guidelines
- date: 2020-10-05
- words: 631
- flesch: 42
- summary: The Competence Network Public Health COVID-19 raised ethical, legal, and epidemiological concerns about questionable benefits for infection control and high psychosocial burden for refugees, and it urged for national guidelines on prevention and management of SARS-CoV-2 in refugee centres. This effectively offers a legal loophole to avoid enforcement of physical distancing in refugee centres to the same extent as for the general population, despite court judgements suspending the obligation of individual refugees to live in crowded centres if physical distancing is not possible.
- keywords: centres; covid-19; germany; guidelines; health; pandemic; political; public; recommendations; refugees; response; rki; und
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- cord-322244-3en3yey1
- author: Nkengasong, John N
- title: Looming threat of COVID-19 infection in Africa: act collectively, and fast
- date: 2020-02-27
- words: 1271
- flesch: 39
- summary: Because mitigating the potential spread of COVID-19 in Africa will require rapid detection and containment, the laboratory work streams of AFTCOR, Africa CDC, and WHO are working closely to expeditiously scale up diagnostic testing capacity linked to enhanced surveillance and monitoring-eg, at the beginning of February, only two countries in Africa had the diagnostic capacity to test for COVID-19. Lastly, the capacity-building training efforts that Africa CDC and WHO are conducting must be implemented and cascaded immediately down the health system pyramid in each country.
- keywords: africa; aftcor; capacity; cases; cdc; china; continent; coronavirus; countries; covid-19; disease; fast; health; high; importation; infection; potential; preparedness; resources; response; risk; spread; strategy; study
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- cord-322541-yzum868k
- author: Moon, Suerie
- title: Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola
- date: 2015-11-23
- words: 11745
- flesch: 36
- summary: That month, both Guinea and Liberia confi rmed Ebola outbreaks to WHO. Fourth, fi eld staff often reinvented strategies for community mobilisation and contact tracing because relevant lessons from previous Ebola outbreaks in Uganda and the Democratic Republic of Congo were not eff ectively transferred.
- keywords: access; accountability; actors; aff; african; appropriate; assessment; assistance; attention; bank; board; budget; building; capacities; capacity; centre; civil; clear; clinical; commission; committee; community; concern; confi; contributions; control; coordination; core; council; countries; country; crisis; data; development; director; disease; disease outbreaks; donors; drugs; early; ebola; ebola outbreak; ebola response; economic; eff; emergencies; emergency; emergency committee; epidemic; essential; external; facility; failures; framework; functions; fund; funding; general; global; global health; governance; governments; group; guinea; health; health emergency; high; humanitarian; independent; infl; information; international; international concern; international health; issues; knowledge; leadership; level; liberia; major; measures; meeting; members; nancing; need; network; new; non; norms; offi; open; organisations; orts; outbreak; outbreak response; panel; phase; political; prevention; private; public; public health; rapid; recommendation; reforms; regional; regulations; report; reporting; research; researchers; resources; response; responsibility; responsible; risk; rules; scientifi; security; sharing; sierra; standing; states; strong; support; system; technical; technology; trade; travel; vaccines; virus; west; workers; world
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- cord-325783-pqonn0as
- author: Nicholls, John M
- title: Lung pathology of fatal severe acute respiratory syndrome
- date: 2003-05-24
- words: 4029
- flesch: 44
- summary: The histological changes of uncomplicated viral pneumonias are rarely described, and reports tend to be derived from post-mortem examination of patients who succumb to the pneumonia; thus, they may not be representative of the majority of pneumonia patients, who survive. key: cord-325783-pqonn0as authors: Nicholls, John M; Poon, Leo LM; Lee, Kam C; Ng, Wai F; Lai, Sik T; Leung, Chung Y; Chu, Chung M; Hui, Pak K; Mak, Kong L; Lim, Wilna; Yan, Kin W; Chan, Kwok H; Tsang, Ngai C; Guan, Yi; Yuen, Kwok Y; Malik Peiris, JS title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 journal: Lancet DOI: 10.1016/s0140-6736(03)13413-7 sha: doc_id: 325783 cord_uid: pqonn0as BACKGROUND: Severe acute respiratory syndrome (SARS) is a novel infectious disease with global impact.
- keywords: acute; adenovirus; alveolar; autopsy; biopsy; cases; cells; changes; chest; clinical; coronavirus; cov; cytoplasm; damage; days; diffuse; disease; electron; epithelial; evidence; failure; features; fever; figure; findings; giant; h5n1; haemophagocytosis; hong; human; infection; influenza; kong; lung; macrophages; march; metaplasia; microscopy; mortem; old; open; patients; pcr; pneumocytes; pneumonia; porcine; post; present; prominent; radiograph; respiratory; ribavirin; samples; sars; severe; squamous; syndrome; tissue; viral; viruses; year
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- cord-325991-dktffiaa
- author: Gross, Oliver
- title: COVID-19-associated nephritis: early warning for disease severity and complications?
- date: 2020-05-06
- words: 597
- flesch: 38
- summary: Three of these patients had coincidentally submitted urine samples in the few weeks before their infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [reference 3·4-5·0 mg/dL]), and urine samples positive for blood, albumin, and leukocytes.
- keywords: admission; complications; cov-2; covid-19; icu; nephritis; patients; samples; sars; syndrome; urine
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- cord-326031-srmpzrzj
- author: MacIntyre, C Raina
- title: Physical distancing, face masks, and eye protection for prevention of COVID-19
- date: 2020-06-01
- words: 1164
- flesch: 39
- summary: This study supports universal face mask use, because masks were equally effective in both healthcare and community settings when adjusted for type of mask use. 15 Finally, Chu and colleagues reiterate that no one intervention is completely protective and that combinations of physical distancing, face mask use, and other interventions are needed to mitigate the COVID19 pandemic until we have an effective vaccine.
- keywords: aor; chu; colleagues; community; covid19; distancing; effective; evidence; face; health; healthcare; masks; physical; protection; respiratory; risk; sarscov2; settings; study; transmission; use; workers
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- cord-327242-g3pfc94x
- author: Nepomnyashchiy, Lyudmila
- title: COVID-19: Africa needs unprecedented attention to strengthen community health systems
- date: 2020-07-16
- words: 1608
- flesch: 50
- summary: Community health workers (CHWs) have insufficient personal protective equipment (PPE) to ensure they can continue providing essential care 14 and most countries face severe shortages of health workers. Lessons from Ebola Community health workers during the Ebola outbreak in Guinea, Liberia, and Sierra Leone Community health worker programmes after the 2013-2016 Ebola outbreak COVID19: it ain't over until there's PPE all over Africa: COVID19 exposes healthcare shortfalls Community health workers and pandemic preparedness: current and prospective roles Xi focus: Xi replies to letter from community workers fighting COVID-19 in Wuhan Prioritising the role of community health workers in the COVID-19 response More harm than good?
- keywords: africa; care; chws; community; coronavirus; countries; cov-2; covid-19; disease; ebola; economic; essential; global; health; human; key; leone; lessons; liberia; months; outbreak; pandemic; ppe; response; saharan; sars; sierra; sub; systems; virus; workers
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- cord-328522-ef4xg3q0
- author: Kelen, Gabor D
- title: Inpatient disposition classification for the creation of hospital surge capacity: a multiphase study
- date: 2006-11-30
- words: 5270
- flesch: 41
- summary: Despite a strong patientsafety movement today, zero risk for an out of hospital consequential medical event as a condition of discharge is not attainable, and must be balanced against risk tolerance for various medical adverse events, including iatrogenic ones. Thus, a need exists to develop an easy method to categorise hospital patients for safe discharge to suitable venues (including early discharge home), taking into account the existence and competence (or lack thereof) of available external resources.
- keywords: acute; adverse; analysis; available; basis; capacity; care; categories; category; cation; classifi; classification; clinical; community; consensus; consequential; consequential medical; critical; data; day; defi; department; disaster; discharge; discussion; disposition; early; emergency; event; exercise; experience; expert; health; high; home; hospital; individual; inpatient; interventions; laboratory; management; medical; medical event; medicine; military; need; nition; panellists; patients; preparedness; process; public; real; report; research; resources; response; reverse; risk; rst; safe; scale; score; severity; specifi; study; surge; surgery; system; time; tolerance; triage; upper; use; warfare
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- cord-328835-r9znjkfo
- author: Favre, Guillaume
- title: 2019-nCoV epidemic: what about pregnancies?
- date: 2020-02-06
- words: 339
- flesch: 46
- summary: Considering that the 2019-nCoV seems to have a similar pathogenic potential as SARS-CoV and MERS-CoV, 4 pregnant women are at increased risk of severe infections, there are no specific clinical signs of coronavirus infections preceding severe complications, 5 coronaviruses have the potential to cause severe maternal or perinatal adverse outcomes, or both, 2,3 and the current lack of data on the consequences of a 2019-nCoV infection during pregnancy, we recommend systematic screening of any suspected 2019-nCoV infection during pregnancy. key: cord-328835-r9znjkfo authors: Favre, Guillaume; Pomar, Léo; Musso, Didier; Baud, David title: 2019-nCoV epidemic: what about pregnancies? date: 2020-02-06 journal: Lancet DOI: 10.1016/s0140-6736(20)30311-1 sha: doc_id: 328835 cord_uid: r9znjkfo nan Members of the coronavirus family responsible for severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV) are known to be responsible for severe complications during pregnancy.
- keywords: coronavirus; cov; ncov; pregnancy; respiratory; severe; women
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- cord-328865-ekgqdjlk
- author: Anand, Shuchi
- title: Prevalence of SARS-CoV-2 antibodies in a large nationwide sample of patients on dialysis in the USA: a cross-sectional study
- date: 2020-09-25
- words: 5654
- flesch: 36
- summary: We also harnessed population data on SARS-CoV-2 cases and deaths and percentage testing positive using nasal swab testing to assess how seroprevalence estimates correlated with other epidemiological measures of COVID-19 incidence. To our knowledge, we provide the first nationally representative estimate of SARS-CoV-2 seroprevalence in the US dialysis and US adult population, and estimates for differences in seroprevalence by neighbourhood race and ethnicity, poverty, population density, and mobility restriction.
- keywords: adult; age; analysis; antibodies; antibody; areas; black; cases; clinical; community; county; cov-2; covid-19; cumulative; data; deaths; density; dialysis; dialysis population; differences; disease; estimates; ethnicity; exposure; health; higher; hispanic; incidence; infection; july; june; laboratory; level; likely; lower; majority; manuscript; measures; mobility; neighbourhoods; new; non; older; pandemic; patients; people; percentage; plasma; population; poverty; race; racial; remainder; representative; response; risk; sample; sampling; sars; sensitivity; seropositivity; seroprevalence; sex; spread; standardised; states; study; surveillance; surveys; testing; united; usa; white; york; zcta
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- cord-329222-o155z3na
- author: Hien, Nguyen Tran
- title: Person-to-person transmission of influenza A (H5N1)
- date: 2008-04-07
- words: 1804
- flesch: 37
- summary: A (H5N1) virus in China Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands Ineffi cient transmission of H5N1 infl uenza viruses in a ferret contact model An avian infl uenza H5N1 virus that binds to a human-type receptor Fatal outcome of human infl uenza Avian infl uenza A (H5N1) in 10 patients in Vietnam Three Indonesian clusters of H5N1 virus infection in 2005 Epidemiology of cases of H5N1 virus infection in Indonesia Two clusters of human infection with infl uenza A/H5N1 virus in the Republic of Azerbaijan Probable limited person-to-person transmission of highly pathogenic avian infl uenza
- keywords: antiretroviral; avian; cacy; coronary; countries; data; disease; effi; family; h5n1; health; heart; host; human; infection; infl; international; patients; person; poultry; probable; randomised; report; risk; studies; term; therapy; today; transmission; trials; uenza; virus; viruses
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- cord-330868-7ocseuz3
- author: Donnelly, Christl A
- title: Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong
- date: 2003-05-24
- words: 3814
- flesch: 44
- summary: If F() and G() are the cumulative distribution functions of the admission-to-death and admission-todischarge distributions, respectively, and F is the case fatality rate-ie, the proportion of SARS patients who will die of the disease-the following likelihood structure is assumed: if a patient died t days after admission, the likelihood is F ϫ[F(t+1)-F(t)]; if a patient was discharged t days after admission, the likelihood is ; and if a patient remained in hospital t days after admission, the likelihood is . However, given the high need for intensive care of patients, the case fatality rate, and public alarm worldwide, use of stringent measures to limit the effective infectious period of probable SARS cases would seem prudent.
- keywords: acute; admission; analysis; april; care; case fatality; cases; clinical; clinical symptoms; clusters; confirmed; data; days; death; department; discharge; distributions; early; epidemic; epidemiological; estimates; fatality; fatality rate; figure; health; hong; hong kong; hospital; incubation; infection; interventions; key; kong; likelihood; march; mean; onset; parametric; patients; period; public; rate; reported; respiratory; sars; severe; spread; symptoms; syndrome; time; transmission; years
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- cord-331643-gmasuqov
- author: King, Tania
- title: Reordering gender systems: can COVID-19 lead to improved gender equality and health?
- date: 2020-06-19
- words: 1315
- flesch: 45
- summary: 8 Much of this is unpaid care work, of which more than 75% is done by women. The unequal distribution of unpaid care work serves as a barrier to female labour force participation and is one way that gender inequalities are reinforced.
- keywords: care; caring; covid-19; effects; employment; equality; female; gender; health; international; labour; leave; norms; organization; pandemic; policies; policy; responsibilities; risk; support; unpaid; women; work
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- cord-333183-xyuj1j57
- author: Lee, Lennard Y W
- title: COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study
- date: 2020-05-28
- words: 4496
- flesch: 40
- summary: Mortality from COVID-19 in cancer patients appears to be principally driven by age, gender, and comorbidities. We are not able to identify evidence that cancer patients on cytotoxic chemotherapy or other anticancer treatment are at an increased risk of mortality from COVID-19 disease compared with those not on active treatment.
- keywords: active; acute; admission; age; analysis; anticancer; birmingham; cancer; cancer patients; care; centres; chemotherapy; clinical; cohort; comorbidities; coronavirus; cov-2; covid-19; cytotoxic; data; death; disease; effect; gender; health; hospital; immunotherapy; infection; local; monitoring; mortality; national; network; non; outcomes; palliative; pandemic; patients; population; positive; project; radiotherapy; recent; reporting; research; risk; sars; severe; significant; studies; study; support; targeted; test; testing; treatments; ukccmp; university; use; weeks
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- cord-334771-uy3s6443
- author: Rao, BL
- title: A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus
- date: 2004-09-09
- words: 3675
- flesch: 45
- summary: Virus was isolated from six patients with encephalitis and was identified as Chandipura virus by electron microscopy, complement fixation, and neutralisation tests. Neutralising, IgG, and IgM antibodies to Chandipura virus were present in some patients' serum samples.
- keywords: acute; agent; analysis; andhra; antibodies; antibody; antigen; blood; brain; cases; cell; chandipura; chandipura virus; children; clinical; csf; data; days; early; electron; encephalitis; evidence; fever; findings; group; igg; igm; illness; india; intellectual; isolation; japanese; laboratory; manuscript; microscopy; negative; neutralisation; neutralising; onset; outbreak; patients; pcr; positive; pradesh; present; rna; samples; serum; state; strain; substantial; tests; throat; tissue; viral; virus; viruses; writing
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- cord-334938-q4xhcxtc
- author: Ouyang, Pingbo
- title: Seeking clarity on retinal findings in patients with COVID-19
- date: 2020-09-17
- words: 355
- flesch: 36
- summary: Because of high light absorption and reflection of the retinal blood and vessel walls, retinal blood vessels can be visualised in OCT images as hyperreflective, tube-like structures with shadows underneath. key: cord-334938-q4xhcxtc authors: Ouyang, Pingbo; Zhang, Xinyu; Peng, Yinghui; Jiang, Bing title: Seeking clarity on retinal findings in patients with COVID-19 date: 2020-09-17 journal: Lancet DOI: 10.1016/s0140-6736(20)31921-8 sha: doc_id: 334938 cord_uid: q4xhcxtc nan Paula M Marinho and colleagues 1 described hyper-reflective lesions in ganglion cell and inner plexiform layers on optical coherence tomography (OCT) images from 24 eyes of 12 adults who had symptoms of COVID-19.
- keywords: colleagues; covid-19; hyper; images; marinho; oct; reflective; retinal
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- cord-335560-fe4ixqdv
- author: Pareek, Manish
- title: Ethnicity and COVID-19: an urgent public health research priority
- date: 2020-04-21
- words: 571
- flesch: 27
- summary: We therefore reviewed published papers and national surveillance reports on notifications and outcomes of COVID-19 to ascertain ethnicity data reporting patterns, associations, and outcomes. More importantly, ethnicity-disaggregated data must occur to permit identification of potential outcome risk factors through adjustment for recognised confounders.
- keywords: bme; care; coronavirus; covid-19; data; differences; disease; ethnicity; health; intensive; mortality; outcomes; pandemic; research; risk
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- cord-337631-w4u6rcnv
- author: Crear-Perry, Joia
- title: Moving towards anti-racist praxis in medicine
- date: 2020-07-17
- words: 1403
- flesch: 37
- summary: Killing rage: ending racism Stolen breaths How to be an antiracist Structural racism and health inequalities in the USA: evidence and interventions Structural racism and health inequities Race isn't a risk factor in maternal health On racism: a new standard for publishing on racial health inequities Why does the shift from personalized medicine to precision health and wellness genomics matter? Dissecting racial bias in an algorithm used to manage the health of populations Race after technology: abolitionist tools for the new Jim Code Artificial intelligence in health care: the hope, the hype, the promise, the peril Can AI help reduce disparities in general medicine and mental health care? Applying an anti-racist lens is not only a moral imperative in health care, it is also an efficient, equitable strategy.
- keywords: algorithmic; anti; care; clinical; competency; education; equity; health; inequities; innovation; justice; medical; medicine; new; outcomes; patients; physicians; race; racial; racism; risk; social; structural; systems; training; usa
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- cord-338516-0x4guveu
- author: Allen, Matilda
- title: A view from UK public health registrars on the challenges of COVID-19
- date: 2020-05-27
- words: 399
- flesch: 43
- summary: key: cord-338516-0x4guveu authors: Allen, Matilda; Braithwaite, Isobel; Collinson, Shelui; Oskrochi, Youssof; Basu, Anamika title: A view from UK public health registrars on the challenges of COVID-19 date: 2020-05-27 journal: Lancet DOI: 10.1016/s0140-6736(20)31058-8 sha: doc_id: 338516 cord_uid: 0x4guveu nan The quotes from frontline workers in Richard Horton's Comment 1 about COVID-19 and the National Health Service (NHS) make for distressing reading, and the risks currently facing our clinical colleagues weigh heavily on our minds. We agree that improved testing capacity, combined with innovative ways to contact trace at scale, are vital.
- keywords: capacity; challenges; contact; covid-19; efforts; health; pandemic; public; testing; transmission
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- cord-339645-0babe90b
- author: Stewart, Ruth
- title: Evidence synthesis communities in low-income and middle-income countries and the COVID-19 response
- date: 2020-10-20
- words: 1072
- flesch: 42
- summary: As a network we have accelerated investment to enable infrastructure for evidence synthesis and to promote evidence use. We need action from individuals, organisations, govern ments, and donors to enable and sustain the generation and use of evidence synthesis in LMICs if we are to tackle COVID-19 globally.
- keywords: available; challenges; communities; countries; covid-19; decision; evidence; global; health; income; lmics; low; making; organisations; pandemic; research; researchers; response; social; support; synthesis
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- cord-341868-btalafo6
- author: Carlet, Jean
- title: Steroids for sepsis and ARDS: this eternal controversy remains with COVID-19
- date: 2020-10-09
- words: 556
- flesch: 58
- summary: Many sepsologists push very hard and without any doubt to include Covid-19 severe cases in the sepsis syndrome. In addition, secondary infections with nosocomial pathogens are very frequent in severe COVID-19 disease, making the prognosis even more complex to evaluate.
- keywords: anti; ards; cases; covid-19; cytokines; disease; infections; patients; sepsis; severe; severity; symptoms
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- cord-342888-o7ezn9dd
- author: Wang, Lei-Yun
- title: Remdesivir and COVID-19
- date: 2020-10-01
- words: 1227
- flesch: 47
- summary: The suggestion made by Jessie K Edwards and colleagues to report the effect of remdesivir stratified by lopinavir-ritonavir is important, although the potential effect of lopinavir-ritonavir was not confirmed in COVID-19 patients. Although the number of confirmed COVID-19 patients at the time was still large in Wuhan, China, there were Samira Asma and colleagues 1 show the complexity of the global monitoring of health-related Sustainable Develop ment Goals (SDGs) and argue for convergence, harmonisation, and strong data science.
- keywords: china; clinical; colleagues; covid-19; day; different; drugs; effect; hazard; improvement; lopinavir; onset; patients; remdesivir; results; ritonavir; severe; study; treatment; trial; usa; wang
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- cord-343219-0dwyv1vk
- author: Gellin, Bruce
- title: Why vaccine rumours stick—and getting them unstuck
- date: 2020-07-30
- words: 1938
- flesch: 50
- summary: That will certainly be the case when COVID-19 vaccines arrive, especially given the many new vaccine technologies that are being tested and the speed at which they are being developed. Thus, it is little surprise that the race to develop COVID-19 vaccines is running at full steam.
- keywords: book; case; challenge; complex; confidence; countries; covid-19; development; distrust; economic; global; health; immunity; larson; level; measures; misinformation; need; new; pandemic; people; population; programmes; public; rumours; safe; social; stick; today; trust; unstuck; vaccination; vaccine; virus
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- cord-345125-s96xufes
- author: McCloskey, Brian
- title: Mass gathering events and reducing further global spread of COVID-19: a political and public health dilemma
- date: 2020-03-20
- words: 1757
- flesch: 30
- summary: World Health Organization Effects of response to 2014-2015 Ebola outbreak on deaths from malaria, HIV/AIDS, and tuberculosis, west Africa Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis Impact of the Mass Drug Administration for malaria in response to the Ebola outbreak in Sierra Leone Malaria control campaign launched in Democratic Republic of the Congo to save lives and aid Ebola response COVID-19) outbreak Public health for mass gatherings: key considerations Mass gatherings medicine: public health issues arising from mass gathering religious and sporting events Global mass gatherings: implications and opportunities for global health security Mass gatherings medicine: international cooperation and progress Olympic and Paralympic Games: public health surveillance and epidemiology European Football Championship finals: planning for a health legacy Hosting of mass gathering sporting events during the 2013-2016 Ebola virus outbreak in west Africa: experience from three African countries Rapid spread of Zika virus in the Americas-implications for public health preparedness for mass gatherings at the 2016 Brazil Olympic Games Saudi Arabia's measures to curb the COVID-19 outbreak: temporary suspension of the Umrah pilgrimage Transmission of respiratory tract infections at mass gathering events Toning down the 2019-nCoV media hype and restoring hope Hajj: infectious disease surveillance and control Key planning recommendations for mass gatherings in the context of the current COVID-19 outbreak. Action plans should include: WHO, working with global partners in MG health, many of whom were involved in the Riyadh conferences and The Lancet's 2014 Mass Gatherings Medicine Series, [4] [5] [6] [7] 13 has developed comprehensive recommendations for managing the public health aspects of MGs that have been updated with interim key recommendations for COVID-19.
- keywords: africa; assessment; coronavirus; countries; covid-19; disease; ebola; events; evidence; gatherings; global; guidance; health; host; international; key; lancet; malaria; mass; measures; mgs; mitigation; outbreak; pandemic; planning; public; response; risk; risk assessment; spread; surveillance; tool; virus; world
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- cord-346015-bzeqs5oh
- author: Wang, Yeming
- title: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
- date: 2020-04-29
- words: 5241
- flesch: 39
- summary: The median age of study patients was 65 years (IQR 56-71); sex distribution was 89 (56%) men versus 69 (44%) women in the remdesivir group and 51 (65%) versus 27 (35%) in the placebo group (table 1). In patients with use of remdesivir within 10 days after symptom onset, 28-day mortality was not significantly different between the groups, although numerically higher in the placebo group; by contrast, in the group of patients with late use, remdesivir patients had numerically higher 28-day mortality, although there was no significant difference.
- keywords: adults; adverse; analysis; antiviral; baseline; china; clinical; control; coronavirus; cov-2; covid-19; daily; data; days; differences; disease; dose; duration; effects; eligible; enrolment; events; group; gs-5734; higher; hospital; human; ill; improvement; infection; invasive; load; lopinavir; mechanical; mers; model; non; onset; oxygen; patients; placebo; placebo group; point; population; primary; randomisation; randomised; rate; ratio; recipients; remdesivir; remdesivir group; respiratory; ritonavir; rna; safety; sars; scale; severe; significant; studies; study; symptom; syndrome; time; treatment; trial; use; ventilation; viral; wang
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- cord-347544-ym7uiqy5
- author: Strathdee, Steffanie A
- title: Confronting antimicrobial resistance beyond the COVID-19 pandemic and the 2020 US election
- date: 2020-09-29
- words: 1077
- flesch: 33
- summary: As the COVID-19 pandemic has shown, efforts are needed to strengthen AMR surveillance and health-care infrastructure and create policies to ensure global equitable access to antimicrobials, diagnostics, and vaccines. Bacterial infections unsuccessfully treated due to AMR claim at least 700 000 lives per year worldwide and are projected to be associated with the deaths of 10 million people per year by 2050, at a cost of US$100 trillion to the global economy through loss of productivity.
- keywords: action; agriculture; amr; antibiotic; antimicrobial; bacterial; countries; covid-19; deaths; global; government; health; infections; national; new; pandemic; plan; progress; resistant; usa; use
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- cord-349624-2sypsfba
- author: Ferigato, Sabrina
- title: The Brazilian Government's mistakes in responding to the COVID-19 pandemic
- date: 2020-10-20
- words: 546
- flesch: 40
- summary: Yet, primary health care has been overlooked by the federal government as a key element in this public health crisis response. The gravity of the pandemic in Brazil is evidenced by the current epidemiological facts: Brazil is among the three countries with the largest number of confirmed cases (more than 5 million as of Oct 15, 2020, according to WHO), with high mortality, 3 evidence of underreporting, 3 and a high number of deaths among health professionals, pregnant women, 4 and the indigenous population.
- keywords: brazil; brazilian; covid-19; covid19; current; federal; government; health; mistakes; pandemic; population; public; response
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- cord-353895-tgn1kk07
- author: Kavanagh, Matthew M
- title: Reckoning with mortality: global health, HIV, and the politics of data
- date: 2020-07-03
- words: 1849
- flesch: 41
- summary: PEPFAR took the bold step, in 2019, of requiring the programmes it funds to report on HIV mortality. Global Burden of Disease Compare Beyond precision: embracing the politics of global health numbers Generation of political priority for global health initiatives: a framework and case study of maternal mortality Metric partnerships: global burden of disease estimates within the World Bank, the World Health Organisation, and the Institute for Health Metrics and Evaluation Counting the dead and what they died from: an assessment of the global status of cause of death data Reliable direct measurement of causes of death in low-and middle-income countries A global assessment of civil registration and vital statistics systems: monitoring data quality and progress Improved retention rates with low-cost interventions in hypertension and diabetes management in a rural African environment of nurse-led care: a cluster-randomised trial Loss-to-follow-up on multidrug resistant tuberculosis treatment in Gujarat, India: the when and who of it Estimation of mortality among HIV-infected people on antiretroviral treatment in East Africa: a sampling based approach in an observational, multisite, cohort study Retention and mortality on antiretroviral therapy in sub-Saharan Africa: collaborative analyses of HIV treatment programmes High proportions of patients with advanced HIV are antiretroviral therapy experienced: hospitalization outcomes from 2 sub-Saharan African sites HIV-related medical admissions to a South African district hospital remain frequent despite effective antiretroviral therapy scale-up Care continuum and postdischarge outcomes among HIV-infected adults admitted to the hospital in Zambia Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy.
- keywords: actual; africa; aids; antiretroviral; care; clinic; countries; data; deaths; disease; efforts; estimates; global; health; high; hiv; income; interventions; level; low; maternal; mortality; patients; people; programmes; registration; south; systems; therapy; treatment; vital; zambia
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- cord-354855-vwxbo01b
- author: Taylor, Allyn L
- title: Solidarity in the wake of COVID-19: reimagining the International Health Regulations
- date: 2020-06-19
- words: 1256
- flesch: 39
- summary: Arms control treaties bear the strongest examples of such inspection mechanisms, but they have also been wielded in other realms of global health, principally the international drug control regime. ALT was a legal adviser at WHO and a consultant to WHO on global health law matters.
- keywords: accountability; capacities; control; countries; covid-19; disease; global; health; ihr; instrument; international; matters; mechanism; obligations; outbreaks; pandemic; pheic; process; public; regulations; reporting; resolution; review; solidarity; states; world
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