# bib

id: cord-322724-7l1668bf
author: Challener, Douglas
title: In Reply - Repeated testing in SARS-CoV-2 infection
date: 2020-08-10
extension: .txt
mime: text/plain
words: 472
sentence: 16
flesch: 39
cache: cache/cord-322724-7l1668bf.txt
txt: txt/cord-322724-7l1668bf.txt
summary:
  In general, we agree that repeat testing may be helpful in certain situations of ongoing high suspicion for active infection where alternative approaches are not feasible; however, we believe that testing should not be applied indiscriminately in a resource-constrained situation. key: cord-322724-7l1668bf authors: Challener, Douglas; Shah, Aditya; O'Horo, John C.; Berbari, Elie F.; Binnicker, Matthew J.; Tande, Aaron title: In Reply - Repeated testing in SARS-CoV-2 infection date: 2020-08-10 journal: Mayo Clin Proc DOI: 10.1016/j.mayocp.2020.08.006 sha: doc_id: 322724 cord_uid: 7l1668bf nan To The Editor: We appreciate the points raised by Lippi et al regarding our article describing repeat testing for SARS-CoV-2 infection.


id: cord-260402-9b1ltcf1
author: Lang, Adam Edward
title: More Than Meets the Eye: The Similarities Between COVID-19 and Smoking
date: 2020-08-11
extension: .txt
mime: text/plain
words: 584
sentence: 22
flesch: 41
cache: cache/cord-260402-9b1ltcf1.txt
txt: txt/cord-260402-9b1ltcf1.txt
summary:
  ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19 COVID-19 and Smoking: How and Why We Implemented a Tobacco Treatment Campaign Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Acute effects of cigarette smoking on platelet-dependent thrombin generation Smoking-Mediated Upregulation of the Androgen Pathway Leads to Increased SARS-CoV-2 Susceptibility Mild versus severe COVID-19: key: cord-260402-9b1ltcf1 authors: Lang, Adam Edward; Yakhkind, Aleksandra title: More Than Meets the Eye: The Similarities Between COVID-19 and Smoking date: 2020-08-11 journal: Mayo Clin Proc DOI: 10.1016/j.mayocp.2020.08.008 sha: doc_id: 260402 cord_uid: 9b1ltcf1 nan To the Editor: Research shows that cigarette smoking upregulates ACE2, the receptor by which SARS-CoV-2 gains entry to the host resulting in COVID-19, in the lungs and therefore potentially leads to increased morbidity [1] .


id: cord-292398-3b2e8x8z
author: Siuka, Darko
title: Vitamin D supplementation in the COVID-19 pandemic
date: 2020-06-06
extension: .txt
mime: text/plain
words: 600
sentence: 20
flesch: 28
cache: cache/cord-292398-3b2e8x8z.txt
txt: txt/cord-292398-3b2e8x8z.txt
summary:
  Therefore, we suggest it would be reasonable to supplement vitamin D in subpopulations at risk of vitamin D deficiency and unfavorable COVID-19 outcomes, as well as in individuals already infected with SARS-CoV-2 to achieve optimal 25(OH)D3 concentrations as quickly as possible. Vitamin D deficiency in adults: when to test and how to treat Vitamin D modulation of innate immune responses to respiratory viral infections Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals European Centre for Disease Prevention and Control.


id: cord-299150-1noy0z88
author: Desai, Aakash
title: Clinical Trial Endpoints in Severe COVID-19
date: 2020-06-06
extension: .txt
mime: text/plain
words: 686
sentence: 30
flesch: 47
cache: cache/cord-299150-1noy0z88.txt
txt: txt/cord-299150-1noy0z88.txt
summary:
  However, clinical trials of agents tested for severe COVID19 may not necessarily test for mortality outcomes as the primary endpoint, as was highlighted in the press release of the recent remdesivir trial. Since drugs improving mortality in severe COVID-19 is the most important endpoint to achieve both from clinical and public policy standpoint, we evaluated the type of primary endpoints currently being assessed in randomized controlled trials (RCTs) in severe COVID19.


id: cord-280123-44206n7t
author: Lucey, Michael R.
title: The Heightened Risk of Fatty Liver Disorders in the Time of COVID-19
date: 2020-10-22
extension: .txt
mime: text/plain
words: 742
sentence: 30
flesch: 51
cache: cache/cord-280123-44206n7t.txt
txt: txt/cord-280123-44206n7t.txt
summary:
  The Relationship between Childhood Obesity, Low Socioeconomic Status, and Race/Ethnicity: Lessons from Massachusetts Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States COVID-19 pandemic brings new concerns about excessive drinking A cohort study examining the interaction of alcohol consumption and obesity in hepatic steatosis and mortality Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD) [6] They used the Mayo Clinic Biobank to ask the question: how do alcohol consumption, body mass, and fatty liver disorder interact?


id: cord-026738-6jtcf4mz
author: Berbari, Elie F.
title: Mayo Clinic Strategies for COVID-19 Introduction
date: 2020-06-13
extension: .txt
mime: text/plain
words: 698
sentence: 34
flesch: 42
cache: cache/cord-026738-6jtcf4mz.txt
txt: txt/cord-026738-6jtcf4mz.txt
summary:
  In January 2020, Mayo Clinic activated its Hospital Incident Command System across all locations in anticipation of a substantial surge in COVID-19 cases. key: cord-026738-6jtcf4mz authors: Berbari, Elie F.; Williams, Amy W.; Williamson, Mary J.; Caine, Natalie A.; Nath, Karl A.; Farrugia, Gianrico title: Mayo Clinic Strategies for COVID-19 Introduction date: 2020-06-13 journal: Mayo Clin Proc DOI: 10.1016/j.mayocp.2020.06.005 sha: doc_id: 26738 cord_uid: 6jtcf4mz nan :xx-xx.


id: cord-329779-5sauq4gp
author: Sanchis-Gomar, Fabian
title: In Reply – Association of Renin Angiotensin System Blockers with Outcomes in Patients With COVID-19
date: 2020-09-14
extension: .txt
mime: text/plain
words: 733
sentence: 21
flesch: 31
cache: cache/cord-329779-5sauq4gp.txt
txt: txt/cord-329779-5sauq4gp.txt
summary:
  Despite a case series from China which reported extremely high AngII in patients with COVID-19, 8 in our cohort of 30 COVID-19 patients, circulating AngII were normal regardless of COVID-19 severity, with no significant differences between COVID-19 patients and healthy controls. Only retrospective observational studies regarding the potentially deleterious effects of ACEIs/ARBs in COVID-19 patients have been conducted to-date, and these findings need to be confirmed in prospective randomized controlled trials (RCT).


id: cord-276194-4sfc7hal
author: Vijayvargiya, Prakhar
title: In Reply–The “Perfect Cytokine Storm” of COVID-19
date: 2020-05-29
extension: .txt
mime: text/plain
words: 796
sentence: 33
flesch: 34
cache: cache/cord-276194-4sfc7hal.txt
txt: txt/cord-276194-4sfc7hal.txt
summary:
  key: cord-276194-4sfc7hal authors: Vijayvargiya, Prakhar; Garrigos, Zerelda Esquer; Castillo Almeida, Natalia E.; Gurram, Pooja R.; Stevens, Ryan W.; Razonable, Raymund R. title: In Reply–The “Perfect Cytokine Storm” of COVID-19 date: 2020-05-29 journal: Mayo Clin Proc DOI: 10.1016/j.mayocp.2020.05.016 sha: doc_id: 276194 cord_uid: 4sfc7hal nan To the Editor:We read with great interest the letter by Testori regarding our Review article Treatment Considerations for COVID-19: A Critical Review of the Evidence (or Lack Thereof), 1 Testori pointed out the important association of pro-inflammatory cytokines in the pathogenesis of Coronavirus disease 2019 , which could account for the worse outcome in older individuals. The Lancet Financial support and conflict of interest disclosure: RRR serves as the principal investigator on clinical trials for tocilizumab and sarilumab.


id: cord-273150-bz617ovx
author: John, Teny M.
date: 2020-06-24
extension: .txt
mime: text/plain
words: 823
sentence: 34
flesch: 40
cache: cache/cord-273150-bz617ovx.txt
txt: txt/cord-273150-bz617ovx.txt
title:
  Migratory Pulmonary Infiltrates in a Patient with COVID-19 Infection and the Role of Corticosteroids

summary:
  Case Presenting Organizing Pneumonia Pattern John 6 Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection COVID-19 and Convalescent Plasma: Frequently Asked Questions The BTK-inhibitor ibrutinib may protect against pulmonary injury in COVID-19 infected patients Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Figure legend: Figure 1: Axial CT chest images on day 7 (day of admission, Panel A) and day 17 after symptom onset (Panel B), showing new and migratory lung infiltrates suggestive of organizing pneumonia Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Longitudinal CT Findings in COVID-19 Pneumonia:


id: cord-298368-vuxp0l50
author: Suh, Gina A.
title: Mayo Clinic Strategies for COVID-19 Avoiding a Medical Education Quarantine During the Pandemic
date: 2020-06-20
extension: .txt
mime: text/plain
words: 879
sentence: 34
flesch: 32
cache: cache/cord-298368-vuxp0l50.txt
txt: txt/cord-298368-vuxp0l50.txt
summary:
  These processes include direct communication via chief medical trainees (residency and fellowship) or an ombudsman serving as a liaison between program leadership and trainees. Another key component of medical education for trainees is hands-on patient care supplemented by teaching rounds.


id: cord-268470-dgxn32ls
author: Sharma, Abhishek
title: Obesity is Associated with More Critical Illness in COVID-19
date: 2020-07-02
extension: .txt
mime: text/plain
words: 934
sentence: 39
flesch: 49
cache: cache/cord-268470-dgxn32ls.txt
txt: txt/cord-268470-dgxn32ls.txt
summary:
  key: cord-268470-dgxn32ls authors: Sharma, Abhishek; Garg, Akash; Rout, Amit; Lavie, Carl J. title: Obesity is Associated with More Critical Illness in COVID-19 date: 2020-07-02 journal: Mayo Clin Proc DOI: 10.1016/j.mayocp.2020.06.046 sha: doc_id: 268470 cord_uid: dgxn32ls nan To the Editor: In follow-up to recent major state-of-the-art review on Obesity and Outcomes in SARS-CoV-2 (COVID-19), 1 we have additional data regarding the relationship of obesity with outcomes in patients with COVID-19. When an Epidemic and Pandemic Collide Healthy Weight and Obesity Prevention: JACC Health Promotion Series Association of obesity with disease severity among patients with COVID-19 Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China (3/13/2020) Lille Intensive Care COVID-19 and Obesity study group.


id: cord-292606-tqjmg3qb
author: Testori, Alessandro
title: THE “PERFECT CYTOKINE STORM” OF COVID-19
date: 2020-05-29
extension: .txt
mime: text/plain
words: 907
sentence: 36
flesch: 42
cache: cache/cord-292606-tqjmg3qb.txt
txt: txt/cord-292606-tqjmg3qb.txt
summary:
  Elderly individuals have lost the ability to control and contain inflammatory processes to the same degree of which younger individuals are capable. The innate immune system plays a central role in inflammation and is also key in its ability to slow down and arrest inflammatory processes.


id: cord-294728-fefkvg0a
author: Vick, Dan J.
title: GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY AND COVID-19 INFECTION
date: 2020-06-06
extension: .txt
mime: text/plain
words: 959
sentence: 48
flesch: 44
cache: cache/cord-294728-fefkvg0a.txt
txt: txt/cord-294728-fefkvg0a.txt
summary:
  12 Hydroxychloroquine may increase the oxidative stress in COVID-19 patients with G6PD deficiency, thereby serving as a trigger for hemolytic anemia. There is evidence to suggest an association between G6PD deficiency and increased susceptibility to, and severity of illness with, COVID-19 infection.


id: cord-255389-2fufd0ba
author: Razonable, Raymund R.
date: 2020-06-23
extension: .txt
mime: text/plain
words: 1024
sentence: 43
flesch: 30
cache: cache/cord-255389-2fufd0ba.txt
txt: txt/cord-255389-2fufd0ba.txt
title:
  Mayo Clinic Strategies for COVID-19 Clinical Guidance and the Delivery of Care for Patients With Coronavirus Disease 2019

summary:
  This clinical team rapidly developed expertise in COVID-19 care because they served as consultants to frontline health care providers. 2, 3 In the process, our medical providers took ownership and implemented the guidance recommendations, which encompassed various aspects of COVID-19 medical care from the time of disease diagnosis until patient recovery.


id: cord-317668-cc5oyiwp
author: Wieland, Mark L.
title: Mayo Clinic Strategies for COVID-19 Community Engagement With Vulnerable Populations
date: 2020-06-22
extension: .txt
mime: text/plain
words: 959
sentence: 41
flesch: 31
cache: cache/cord-317668-cc5oyiwp.txt
txt: txt/cord-317668-cc5oyiwp.txt
summary:
  The focus of multisector collaboration and community engagement should be to inform programs and policies that will eliminate the disproportionate impact of pandemics on vulnerable communities. For example, community health center partners needed telehealth infrastructure support to provide ongoing care, but this was not feasible within the CEnR framework.


id: cord-324660-w81jgw7p
author: Guharoy, Roy
title: Medication Shortages: A Matter of National Security—Time for Action
date: 2020-08-01
extension: .txt
mime: text/plain
words: 1106
sentence: 38
flesch: 38
cache: cache/cord-324660-w81jgw7p.txt
txt: txt/cord-324660-w81jgw7p.txt
summary:
  As supply chain management leaders at Mayo Clinic, we appreciate the attention these authors draw towards the issue of drug shortages and drug costs. One of the interesting observations we have made from the supply chain perspective while navigating the coronavirus disease 2019 (COVID-19) pandemic is that the impacts on drug cost from COVID-19 have been minimal in the retail segment and are more significant in the hospital sector.


id: cord-256422-4crdzojb
author: Garg, Aakash
title: Association of Renin Angiotensin System Blockers With Outcomes in Patients with COVID-19
date: 2020-09-14
extension: .txt
mime: text/plain
words: 1033
sentence: 49
flesch: 39
cache: cache/cord-256422-4crdzojb.txt
txt: txt/cord-256422-4crdzojb.txt
summary:
  Hypertension COVID-19 with Different Severity: A Multi-center Study of Clinical Features Clinical Course and Outcomes of 344 Intensive Care Patients with COVID-19 Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. From individual studies, we collected baseline characteristics of patients including proportion of patients with HTN and those taking ACEI/ARB.


id: cord-318205-qxkel0ww
author: Parkulo, Mark A.
title: Risk of SARS-CoV-2 Transmission Among Coworkers in a Surgical Environment
date: 2020-10-22
extension: .txt
mime: text/plain
words: 1271
sentence: 55
flesch: 54
cache: cache/cord-318205-qxkel0ww.txt
txt: txt/cord-318205-qxkel0ww.txt
summary:
  Infections of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) among health care workers is a serious consequence of the coronavirus disease 2019 (COVID-19) pandemic. 2, 3 Here we report the outcome of a widespread surveillance program in a surgical area which was implemented as a result of health care workers testing positive for SARS-CoV-2 at Mayo Clinic, Jacksonville, Florida.


id: cord-269568-vwkawh6x
author: Ten Hulzen, Richard D.
title: Impact of Hearing Loss and Universal Face Masking in the COVID-19 Era.
date: 2020-08-03
extension: .txt
mime: text/plain
words: 1085
sentence: 34
flesch: 33
cache: cache/cord-269568-vwkawh6x.txt
txt: txt/cord-269568-vwkawh6x.txt
summary:
  There are three major categories of masks being used to limit the airborne transmission of large respiratory droplets and infectious agents: a respirator, or filtering face piece (FFP), such as a N95 mask; medical face masks, such as a surgical or procedure mask; and nonmedical masks, such as commercially-or self-made masks usually made of cloth or other textiles. 2 Hearing loss impacts all age groups, yet it is more prevalent among unscreened older adults-who are also likely to be without hearing assistance.


id: cord-315388-8sv00zqz
author: Ghosh, Ritwik
title: Famotidine against SARS-CoV2: A hope or hype?
date: 2020-06-06
extension: .txt
mime: text/plain
words: 1101
sentence: 44
flesch: 31
cache: cache/cord-315388-8sv00zqz.txt
txt: txt/cord-315388-8sv00zqz.txt
summary:
  It has been documented that famotidine completely demolishes H2R mediated negative effects on cytokine production, especially tumor necrosis factor (TNF)-α, interferon-γ) Cardiac failure and arrhythmias have also been reported with high doses of intravenous famotidine administration [19] .


id: cord-030903-hhhjwoei
author: Sinsky, Christine A.
title: Implementing Telemedicine in Primary Care: Learning Lessons From Electronic Health Records
date: 2020-08-27
extension: .txt
mime: text/plain
words: 1306
sentence: 51
flesch: 48
cache: cache/cord-030903-hhhjwoei.txt
txt: txt/cord-030903-hhhjwoei.txt
summary:
  And yet the EHR was not the savior of primary care, 3 but instead, for all of its benefits, its burdens fell disproportionately to primary care physicians. Inequity in payment for cognitive versus procedural care 2 ; conflating how primary care has been valued with its value; equating the payment allocated for primary care services with the difficulty in their mastery (contributing to the assumption that lesser training is of little consequence in primary care); and a shrinking scope of practice for physicians within the specialty are among the reasons our health system has not benefitted fully from what a well-supported, well-organized model of primary care has to offer.


id: cord-302513-u9n56pnb
author: Breitinger, Scott
title: Key Opportunities for the COVID-19 Response to Create a Path to Sustainable Telemedicine Services
date: 2020-10-01
extension: .txt
mime: text/plain
words: 1273
sentence: 50
flesch: 38
cache: cache/cord-302513-u9n56pnb.txt
txt: txt/cord-302513-u9n56pnb.txt
summary:
  To maintain the progress made possible by this pandemic, some well-intended regulatory parameters of telehealth could be revised to permit greater freedom for patients, providers, health care systems and states to connect patients' needs with effective health care. During the COVID-19 era, telemedicine has been an essential method to ensure the continuation of health care services while allowing for social distancing and reducing rates of COVID-19 transmission.


id: cord-328548-5kjq9xqs
author: Oliveira J. e Silva, Lucas
title: Flexibilization of Science, Cognitive Biases, and the COVID-19 Pandemic
date: 2020-08-27
extension: .txt
mime: text/plain
words: 1463
sentence: 55
flesch: 38
cache: cache/cord-328548-5kjq9xqs.txt
txt: txt/cord-328548-5kjq9xqs.txt
summary:
  Despite being arguably the lowest quality of scientific proof, there are several reasons to believe that anecdotal evidence, in particular, may be accorded more credence than such evidence truly merits. The term flexibilization here refers to a loosening of methodological standards and the development of low-quality studies, leading to the creation of unreliable data and, later in the cycle, of anecdotal evidence.


id: cord-261653-0vtghtp7
author: Andersen, Kylie J.
title: Recruitment Strategy for Potential COVID-19 Convalescent Plasma Donors
date: 2020-09-21
extension: .txt
mime: text/plain
words: 1668
sentence: 61
flesch: 36
cache: cache/cord-261653-0vtghtp7.txt
txt: txt/cord-261653-0vtghtp7.txt
summary:
  Rochester, Minnesota required a strategy to interface with the community of recovering COVID-19 patients and recruit eligible convalescent plasma donors. This strategy may be adopted by other institutions to rapidly increase convalescent plasma donor recruitment.


id: cord-007864-kxyu5nzp
author: Sampathkumar, Priya
date: 2011-10-20
extension: .txt
mime: text/plain
words: 2162
sentence: 90
flesch: 48
cache: cache/cord-007864-kxyu5nzp.txt
txt: txt/cord-007864-kxyu5nzp.txt
title:
  Dealing With Threat of Drug-Resistant Tuberculosis: Background Information for Interpreting the Andrew Speaker and Related Cases

summary:
  Another important factor resulting in increasing numbers of TB cases is the increase in transmission of multidrugresistant (MDR) strains of TB (Table 1 ). The communicable diseases for which federal isolation and quarantine are authorized by presidential order are infectious TB, cholera, diphtheria, plague, smallpox, yellow fever, viral hemorrhagic fevers, SARS, and influenza with pandemic potential.


id: cord-285569-ei9w19i7
author: Shah, Aditya
title: Guide to Understanding the 2019 Novel Coronavirus
date: 2020-02-28
extension: .txt
mime: text/plain
words: 2062
sentence: 103
flesch: 47
cache: cache/cord-285569-ei9w19i7.txt
txt: txt/cord-285569-ei9w19i7.txt
summary:
  27, 28 Deaths appear to be occurring predominantly in the elderly, with a median age of 75 years in reported cases, but lately, younger patients have died as well. World Health Organization website Severe acute respiratory syndrome The severe acute respiratory syndrome Summary of probable SARS cases with onset of illness from 1 Lack of SARS transmission among healthcare workers, United States SARS: epidemiology, clinical presentation, management, and infection control measures Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease.


id: cord-325938-hb6fvgem
author: Dobler, Claudia C.
title: Non-Invasive Positive Pressure Ventilation in Patients With COVID-19
date: 2020-10-08
extension: .txt
mime: text/plain
words: 2559
sentence: 86
flesch: 31
cache: cache/cord-325938-hb6fvgem.txt
txt: txt/cord-325938-hb6fvgem.txt
summary:
  Often requires sedation, inability for patient to communicate and may have increased association with delirium and posttraumatic stress disorder • May be associated with longer hospitalization and higher mortality compared to patients who have avoided intubation on NIPPV d • Risk of vocal cord damage, procedural hypotension, and other adverse effects directly associated with placement of an endotracheal tube • Potential for lung injury associated with positive endexpiratory pressure • High risk of viral transmission during intubation (can be limited by techniques of apneic oxygenation and rapid sequence intubation with paralysis) and also during Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 Covid-19 Does Not Lead to a Typical Acute Respiratory Distress Syndrome Association of Home Noninvasive Positive Pressure Ventilation With Clinical Outcomes in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) Guidance for the role and use of non-invasive respiratory support in adult patients with COVID19 (confirmed or suspected) National Institutes of Health (NIH). From an American Thoracic Society-led International Task Force Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Use of non-invasive ventilation for patients with COVID-19: a cause for concern?


id: cord-303747-o09canse
author: Bennett, Courtney E.
date: 2020-04-11
extension: .txt
mime: text/plain
words: 2584
sentence: 76
flesch: 22
cache: cache/cord-303747-o09canse.txt
txt: txt/cord-303747-o09canse.txt
title:
  ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties

summary:
  These experiences emphasize the need for health care facilities to rapidly prepare and configure their own STEMI systems of care in anticipation of treating increasing numbers of COVID-19 patients whose clinical course is complicated by the appearance of STE on their electrocardiogram. This algorithm seeks to achieve the following objectives: 1) the accurate identification of patients with type 1 or type 2 MI who would benefit from reperfusion therapy and revascularization; 2) the minimization/avoidance of unnecessary exposure of COVID-19 patients to invasive care and pharmacological management that may result in clinical harm; and 3) a strategy to wisely utilize resources and avoid unnecessary exposure to a potentially fatal infectious agent.


id: cord-319023-ucm8frol
author: Nuzzo, Andrea
date: 2020-06-22
extension: .txt
mime: text/plain
words: 3144
sentence: 138
flesch: 39
cache: cache/cord-319023-ucm8frol.txt
txt: txt/cord-319023-ucm8frol.txt
title:
  Universal Shelter-in-Place vs. Advanced Automated Contact Tracing and Targeted Isolation: A Case for 21st-Century Technologies for SARS-CoV-2 and Future Pandemics

summary:
  For contact tracing, we assumed an advanced, automated contact tracing (AACT) application that sends alerts to individuals advising self-isolation based on individual exposure profile. Contact tracing is routinely used for controlling infectious diseases.


id: cord-322714-s0wge7o4
author: Joyner, Michael J.
title: Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients
date: 2020-07-19
extension: .txt
mime: text/plain
words: 3295
sentence: 126
flesch: 40
cache: cache/cord-322714-s0wge7o4.txt
txt: txt/cord-322714-s0wge7o4.txt
summary:
  Although thrombotic and thromboembolic events are emerging clinical complications of COVID-19 11, 12, 20 , our data demonstrate a low rate (<1%) of these events within the first seven days after COVID-19 convalescent plasma transfusion. Patients and Methods From April 3 to June 2, 2020, the US FDA Expanded Access Program for COVID-19 convalescent plasma transfused a convenience sample of 20,000 hospitalized patients with COVID-19 convalescent plasma.


id: cord-334708-lbmktall
author: Putman, Michael S.
title: Publication Rate and Journal Review Time of COVID-19 Related Research
date: 2020-08-31
extension: .txt
mime: text/plain
words: 438
sentence: 22
flesch: 43
cache: cache/cord-334708-lbmktall.txt
txt: txt/cord-334708-lbmktall.txt
summary:
  Anecdotally, academic researchers have noticed a reduction in the amount of time journals require to review COVID-19 manuscripts. In this letter we describe the growth of this literature and the review time of COVID-19 related manuscripts.


id: cord-331754-4cssullk
author: Shakshouk, Hadir
title: Purple Fingers and Toes
date: 2020-05-20
extension: .txt
mime: text/plain
words: 549
sentence: 26
flesch: 29
cache: cache/cord-331754-4cssullk.txt
txt: txt/cord-331754-4cssullk.txt
summary:
  Perniosis, also known as chilblains, is a cold-induced inflammatory disorder commonly affecting acral sites and is frequently accompanied by a sensation of itching, burning, or pain. Affected patients develop vasoconstriction in acral sites instead of the protective vasodilatory response.


id: cord-298094-ctikhqvr
author: Elias, Pierre
date: 2020-08-15
extension: .txt
mime: text/plain
words: 4172
sentence: 189
flesch: 47
cache: cache/cord-298094-ctikhqvr.txt
txt: txt/cord-298094-ctikhqvr.txt
title:
  The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19

summary:
  6 Electrocardiographic (ECG) abnormalities have been described but there have been no large studies of ECG abnormalities in COVID-19 patients nor their correlation with clinical outcomes. We propose that in the setting of triaging COVID-19 patients in the ED, ECG be treated as a sixth vital sign.


id: cord-337172-vgw8uz83
author: Kaltenboeck, Anna
title: The Case for Masks – Health Care Workers Can Benefit, Too
date: 2020-04-20
extension: .txt
mime: text/plain
words: 1285
sentence: 60
flesch: 53
cache: cache/cord-337172-vgw8uz83.txt
txt: txt/cord-337172-vgw8uz83.txt
summary:
  Four months into the pandemic, there are models of possible trajectories of the disease but there are still no clear, national recommendations to guide practice that could reduce the spread of infection in hospitals facing limited availability of personal protective equipment (PPE) including surgical masks and N95 masks. The CDC recently followed suit, recommending that the general public wear makeshift masks in public areas where social distancing is difficult.


id: cord-345058-jfzzngce
author: Baughn, Linda B.
title: Targeting TMPRSS2 in SARS-CoV-2 infection
date: 2020-07-19
extension: .txt
mime: text/plain
words: 1719
sentence: 60
flesch: 41
cache: cache/cord-345058-jfzzngce.txt
txt: txt/cord-345058-jfzzngce.txt
summary:
  TMPRSS2 expression was also detected in gastrointestinal tissues, including stomach, colon (transverse), pancreas, small intestine (terminal ileum), minor salivary gland, esophagus (mucosa), liver and colon (sigmoid) ( Figure 1B ). Targeting TMPRSS2 protease activity through protease inhibitors or indirectly through ADT will require additional studies to determine the role of rs75603675 and rs12329760 on TMPRSS2 expression, protease activity and in response to protease inhibition.


id: cord-343227-6n5el4hz
author: Fischer, Philip R.
title: Intentionality in Medical School Admissions in the COVID-19 Era
date: 2020-09-24
extension: .txt
mime: text/plain
words: 1571
sentence: 64
flesch: 53
cache: cache/cord-343227-6n5el4hz.txt
txt: txt/cord-343227-6n5el4hz.txt
summary:
  And yet we wish to gently challenge a tendency towards solipsism-a propensity for self-absorption -as aspiring medical students face what Bhatt and Bhatt describe as an increased sense of stress as carefully charted paths to medical school become so utterly disrupted. If getting into medical school is a dance, it is as if we have been perfecting our plies and jetes for the ballet recital for years, only to be told just before the performance that we will be expected to show off our jazz and hip-hop moves instead.


id: cord-258307-nsdhvc8w
author: Maki, Dennis G.
date: 2011-10-20
extension: .txt
mime: text/plain
words: 5024
sentence: 156
flesch: 35
cache: cache/cord-258307-nsdhvc8w.txt
txt: txt/cord-258307-nsdhvc8w.txt
title:
  SARS Revisited: The Challenge of Controlling Emerging Infectious Diseases at the Local, Regional, Federal, and Global Levels

summary:
  [20] [21] [22] Because SARS is such a unique human viral infection and induces such an unusually severe systemic inflammatory response, 18, 19 it will be important to closely follow survivors of severe SARS for considerably longer to be certain that latently expressed progressive pulmonary fibrosis does not occur. Whereas uncontrolled studies of treated cohorts in Asia have suggested that using moderate doses of corticosteroids, 1 to 2 mg/kg of a prednisone-equivalent daily, at the first evidence of severe SARS, specifically hypoxemia, may improve survival, 59,61,62 corticosteroid therapy for SARS has had serious adverse effects, 63 and a single randomized trial of preemptive pulse corticosteroid therapy did not show benefit.


id: cord-330104-wgo4pml6
author: Farrugia, Gianrico
title: Innovation Lessons From the COVID-19 Pandemic
date: 2020-06-06
extension: .txt
mime: text/plain
words: 1672
sentence: 65
flesch: 42
cache: cache/cord-330104-wgo4pml6.txt
txt: txt/cord-330104-wgo4pml6.txt
summary:
  In the ensuing weeks, health care organizations, industry partners, and government agencies worldwide have quickly come together to address pandemic challenges such as scaling high-quality laboratory tests, conducting treatment research, and enabling virtual health care in a time of social distancing. 2 To stem pandemic-related deaths and prevent health care systems from being overwhelmed with sick patients, governments responded by limiting travel, closing schools, issuing stay-at-home orders, making emergency investments in health care, scaling testing, and using data and technology to trace contacts.


id: cord-346607-1mewok8l
author: Oesterle, Tyler S.
title: Substance Use Disorders and Telehealth in the COVID-19 Pandemic Era: A New Outlook
date: 2020-10-21
extension: .txt
mime: text/plain
words: 4952
sentence: 194
flesch: 40
cache: cache/cord-346607-1mewok8l.txt
txt: txt/cord-346607-1mewok8l.txt
summary:
  Many longitudinal outcome studies have allowed researchers to look at which aspects of SUD treatment patient have deemed most helpful to their recovery. A number of studies have shown group based treatment by videoconference, both support groups and treatment groups, including those targeting tobacco, alcohol and opioid use disorders have been shown to provide safe intervention, high patient satisfaction and appear to have similar outcomes to in person treatments.


