id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-254162-tu81j66h	Bai, Xiyuan	Hypothesis: alpha-1-antitrypsin is a promising treatment option for COVID-19	2020-11-12		.txt	text/plain	5552	168	25	AAT inhibition of ADAM17 also prevents shedding of ACE2 and hence may preserve ACE2 inhibition of bradykinin, reducing the ability of bradykinin to cause a capillary leak in COVID-19. Sixth, AAT inhibition of elastase can antagonize the formation of neutrophil extracellular traps (NETs), a complex extracellular structure comprised of neutrophil-derived DNA, histones, and proteases, and implicated in the immunothrombosis of COVID-19; indeed, AAT has been shown to change the shape and adherence of non-COVID-19-related NETs.	cache/cord-254162-tu81j66h.txt	txt/cord-254162-tu81j66h.txt
