id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-276564-o21ncldx	Miller, R.	COVID-19: NAD(+) deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity	2020-06-29		.txt	text/plain	3232	112	31	(39) COVID-19 replication and SIRT1 SIRT1 not only controls and modifies the inflammatory response, but along with the Sirtuin family (SIRT1-7) is also a primary defence against DNA and RNA viral pathogens. COVID-19: NAD + deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity We hypothesize that reduced Nicotinamide Adenine Dinucleotide (NAD + ) levels with consequent deficient activity of the NAD + dependent molecule SIRT1, which modulates cytokine production, may be the factor that predisposes the aged, obese, type 2 diabetics and other vulnerable groups to an increased mortality.	cache/cord-276564-o21ncldx.txt	txt/cord-276564-o21ncldx.txt
