id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-299911-v95pf3eg	El-Ghiaty, Mahmoud A.	Cytochrome P450-mediated drug interactions in COVID-19 patients: current findings and possible mechanisms	2020-06-26		.txt	text/plain	5332	208	31	IL-1 beta counteracts clofibric acid induction of CYP4A in cultured fetal rat hepatocytes Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site Effects of interleukin 1beta (IL-1beta) and IL-1beta/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha Nitric oxidemediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: the role of cytokines The interleukin-2 receptor downregulates the expression of cytochrome P450 in cultured rat hepatocytes Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy In vivo effects of interleukin-10 on human cytochrome P450 activity Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver Cytochrome P450 down-regulation by serum from humans with a viral infection and from rabbits with an inflammatory reaction Effect of interleukin 6 on phenobarbital induction of cytochrome P-450IIB in cultured rat hepatocytes Chauvelot-Moachon L. Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6 Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6-and interferon-{gamma}-null mice Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute-phase response Transgenic mouse models of human CYP3A4 gene regulation Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies Extrahepatic cancer represses hepatic drug metabolism via interleukin (IL)-6 signalling Effects of cytokines on CYP3A4 expression and reversal of the effects by anti-cytokine agents in the three-dimensionally cultured human hepatoma cell line FLC-4 Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture Gene transcription in hepatocytes during the acute phase of a systemic inflammation: from transcription factors to target genes Regulation of cytochrome p450 by inflammatory mediators: why and how? NF-kappaB and the immune response Role of NF-kappaB in the regulation of cytochrome P450 enzymes Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide Ah receptor and NF-kappaB interactions: mechanisms and physiological implications Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6 Inhibition of nuclear factor-kappaB signal by pyrrolidine dithiocarbamate alleviates lipopolysaccharide-induced acute lung injury Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer? = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection Liver injury in COVID-19: management and challenges COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies COVID-19 and liver disease Systemic viral infections and collateral damage in the liver Kupffer cell-dependent hepatitis occurs during influenza infection Liver involvement during influenza infection: perspective on the 2009 influenza pandemic Complex Drug-Drug Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives Trends in new drug interactions for pharmaceutical products in Japan Infection and inflammation leading to clozapine toxicity and intensive care: a case series Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis Influence of chronic hepatitis C infection on cytochrome P450 3A4 activity using midazolam as an in vivo probe substrate Drug-disease interaction: Crohn's disease elevates verapamil plasma concentrations but reduces response to the drug proportional to disease activity Variability in drug metabolizing enzyme activity in HIV-infected patients Altered theophylline clearance during an influenza B outbreak The use of imipramine in depressed patients with congestive heart failure Understanding Disease-Drug Interactions in Cancer Patients: Implications for Dosing Within the Therapeutic Window Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-lnterleukin-6 monoclonal antibody (Sirukumab) and cytochrome P450 activities in a phase I study in patients with rheumatoid arthritis using a cocktail approach A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: suppression of CYP3A by IL-6 Development of a Physiologically Based Pharmacokinetic Model to Predict Disease-Mediated Therapeutic Protein-Drug Interactions: Modulation of Multiple Cytochrome Physiologically Based Pharmacokinetic Model to Assess the Influence of Blinatumomab-Mediated Cytokine Elevations on Cytochrome P450 Enzyme Activity Summary on compassionate use of Remdesivir Gilead Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing Ndesethylchloroquine formation Colchicine--Update on mechanisms of action and therapeutic uses Critical Care Utilization for the COVID-19 Early Experience and Forecast During an Emergency Response Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilator-days and deaths by US state in the next 4 months Drug-associated disease: cytochrome P450 interactions Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region Clinical implications from drug-drug and drug-disease interactions in older people An update on the clinical consequences of polypharmacy in older adults: a narrative review	cache/cord-299911-v95pf3eg.txt	txt/cord-299911-v95pf3eg.txt
