id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-269563-2979u47a	Caetano Silva-Filho, José	The influence of ABO blood groups on COVID-19 susceptibility and severity: a molecular hypothesis based on carbohydrate-carbohydrate interactions	2020-08-02		.txt	text/plain	4621	143	29	Supported by an extensive bibliographic review highlighting (i) the mode of binding of SARS-CoV-2 to cell receptors, as well as (ii) the biochemical aspects of ABO blood group system and its association to infection and some circulatory conditions, we hypothesize that the influence of blood type on COVID-19 severity relies on the differential clustering of glycoproteins receptors to SARS-CoV-2 on host cell surface, induced by ABH antigens through carbohydrate-carbohydrate interactions with the glycan portions of these receptors, which could modulate virus binding to the target cell. In summary, this work proposes that the molecular mechanism underlying the influence of ABO blood groups on COVID-19 susceptibility and severity relies on carbohydrate-carbohydrate interactions between ABH antigens and sialoside glycans present on host cell receptors.	cache/cord-269563-2979u47a.txt	txt/cord-269563-2979u47a.txt
