id sid tid token lemma pos njb-44 1 1 microsoft microsoft PROPN njb-44 1 2 word word PROPN njb-44 1 3 paper paper NOUN njb-44 1 4 4 4 NUM njb-44 1 5 deswal deswal NOUN njb-44 1 6 author author NOUN njb-44 1 7 copy.doc copy.doc PROPN njb-44 1 8 nepal nepal ADJ njb-44 1 9     SPACE njb-44 1 10 journal journal NOUN njb-44 1 11     SPACE njb-44 1 12 of of ADP njb-44 1 13     SPACE njb-44 1 14 biotechnology biotechnology NOUN njb-44 1 15 . . PUNCT njb-44 1 16         SPACE njb-44 2 1 jan jan PROPN njb-44 2 2     SPACE njb-44 2 3 2012 2012 NUM njb-44 2 4 , , PUNCT njb-44 2 5     SPACE njb-44 2 6 vol vol NOUN njb-44 2 7 . . PUNCT njb-44 2 8     SPACE njb-44 3 1 2 2 NUM njb-44 3 2 , , PUNCT njb-44 3 3     SPACE njb-44 3 4 no no INTJ njb-44 3 5 . . PUNCT njb-44 3 6     SPACE njb-44 4 1 1 1 NUM njb-44 4 2 : : PUNCT njb-44 4 3     SPACE njb-44 4 4 62 62 NUM njb-44 4 5     SPACE njb-44 4 6 – – PUNCT njb-44 4 7     SPACE njb-44 4 8 71 71 NUM njb-44 4 9                                                                                                                                                                                                                                         SPACE njb-44 4 10 biotechnology biotechnology NOUN njb-44 4 11     SPACE njb-44 4 12 society society NOUN njb-44 4 13     SPACE njb-44 4 14 of of ADP njb-44 4 15     SPACE njb-44 4 16 nepal nepal NOUN njb-44 4 17     SPACE njb-44 4 18 ( ( PUNCT njb-44 4 19 bsn bsn PROPN njb-44 4 20 ) ) PUNCT njb-44 4 21 , , PUNCT njb-44 4 22     SPACE njb-44 4 23 all all DET njb-44 4 24     SPACE njb-44 4 25 rights right NOUN njb-44 4 26     SPACE njb-44 4 27 reserved reserve VERB njb-44 4 28     SPACE njb-44 4 29 62 62 NUM njb-44 4 30 review review NOUN njb-44 4 31 article article NOUN njb-44 4 32 models model NOUN njb-44 4 33     SPACE njb-44 4 34 of of ADP njb-44 4 35     SPACE njb-44 4 36 t t NOUN njb-44 4 37     SPACE njb-44 4 38 cell cell NOUN njb-44 4 39     SPACE njb-44 4 40 antigen antigen NOUN njb-44 4 41     SPACE njb-44 4 42 receptor receptor NOUN njb-44 4 43     SPACE njb-44 4 44 activation activation NOUN njb-44 4 45 : : PUNCT njb-44 4 46     SPACE njb-44 4 47 the the DET njb-44 4 48     SPACE njb-44 4 49 puzzle puzzle NOUN njb-44 4 50     SPACE njb-44 4 51 still still ADV njb-44 4 52     SPACE njb-44 4 53 remained remain VERB njb-44 4 54     SPACE njb-44 4 55 sumit sumit NOUN njb-44 4 56 deswala deswala PROPN njb-44 4 57 , , PUNCT njb-44 4 58 b b NOUN njb-44 4 59 adepartment adepartment NOUN njb-44 4 60 of of ADP njb-44 4 61 molecular molecular ADJ njb-44 4 62 immunology immunology NOUN njb-44 4 63 , , PUNCT njb-44 4 64 max max PROPN njb-44 4 65 planck planck PROPN njb-44 4 66 institute institute PROPN njb-44 4 67 of of ADP njb-44 4 68 immunobiology immunobiology PROPN njb-44 4 69 and and CCONJ njb-44 4 70 epigenetics epigenetic NOUN njb-44 4 71 and and CCONJ njb-44 4 72 faculty faculty NOUN njb-44 4 73 of of ADP njb-44 4 74 biology biology PROPN njb-44 4 75 iii iii PROPN njb-44 4 76 , , PUNCT njb-44 4 77 university university NOUN njb-44 4 78 of of ADP njb-44 4 79 freiburg freiburg NOUN njb-44 4 80 , , PUNCT njb-44 4 81 stübeweg stübeweg PROPN njb-44 4 82 51 51 NUM njb-44 4 83 , , PUNCT njb-44 4 84 79108 79108 NUM njb-44 4 85 freiburg freiburg NOUN njb-44 4 86 , , PUNCT njb-44 4 87 germany germany PROPN njb-44 4 88 bspemann bspemann PROPN njb-44 4 89 graduate graduate NOUN njb-44 4 90 school school NOUN njb-44 4 91 of of ADP njb-44 4 92 biology biology NOUN njb-44 4 93 and and CCONJ njb-44 4 94 medicine medicine NOUN njb-44 4 95 ( ( PUNCT njb-44 4 96 sgbm sgbm NOUN njb-44 4 97 ) ) PUNCT njb-44 4 98 , , PUNCT njb-44 4 99 university university NOUN njb-44 4 100 of of ADP njb-44 4 101 freiburg freiburg NOUN njb-44 4 102 , , PUNCT njb-44 4 103 germany germany PROPN njb-44 4 104 corresponding corresponding ADJ njb-44 4 105 address address NOUN njb-44 4 106 : : PUNCT njb-44 4 107 max max PROPN njb-44 4 108 planck planck PROPN njb-44 4 109 institute institute PROPN njb-44 4 110 of of ADP njb-44 4 111 immunobiology immunobiology PROPN njb-44 4 112 and and CCONJ njb-44 4 113 epigenetics epigenetic NOUN njb-44 4 114 , , PUNCT njb-44 4 115 stübeweg stübeweg PROPN njb-44 4 116 51 51 NUM njb-44 4 117 , , PUNCT njb-44 4 118 79108 79108 NUM njb-44 4 119 freiburg freiburg NOUN njb-44 4 120 , , PUNCT njb-44 4 121 germany germany PROPN njb-44 4 122 . . PUNCT njb-44 5 1 e e X njb-44 5 2 - - NOUN njb-44 5 3 mail mail NOUN njb-44 5 4 : : PUNCT njb-44 5 5 deswal@immunbio.mpg.de deswal@immunbio.mpg.de NOUN njb-44 5 6 , , PUNCT njb-44 5 7 tel tel NOUN njb-44 5 8 . . PUNCT njb-44 5 9 : : PUNCT njb-44 6 1 +49 +49 NOUN njb-44 6 2 - - PUNCT njb-44 6 3 761 761 NUM njb-44 6 4 - - NUM njb-44 6 5 5108 5108 NUM njb-44 6 6 - - SYM njb-44 6 7 314 314 NUM njb-44 6 8 , , PUNCT njb-44 6 9 fax fax PROPN njb-44 6 10 : : PUNCT njb-44 6 11 +49 +49 PROPN njb-44 6 12 - - PUNCT njb-44 6 13 761 761 NUM njb-44 6 14 - - NUM njb-44 6 15 5108 5108 NUM njb-44 6 16 - - PUNCT njb-44 6 17 423 423 NUM njb-44 6 18 abstract abstract ADJ njb-44 6 19 t t PROPN njb-44 6 20 cell cell NOUN njb-44 6 21 antigen antigen PROPN njb-44 6 22 receptor receptor PROPN njb-44 6 23 ( ( PUNCT njb-44 6 24 tcr tcr PROPN njb-44 6 25 ) ) PUNCT njb-44 6 26 is be AUX njb-44 6 27 a a DET njb-44 6 28 protein protein NOUN njb-44 6 29 - - PUNCT njb-44 6 30 complex complex NOUN njb-44 6 31 expressed express VERB njb-44 6 32 on on ADP njb-44 6 33 all all DET njb-44 6 34 t t PROPN njb-44 6 35 cells cell NOUN njb-44 6 36 of of ADP njb-44 6 37 the the DET njb-44 6 38 immune immune ADJ njb-44 6 39 system system NOUN njb-44 6 40 and and CCONJ njb-44 6 41 is be AUX njb-44 6 42 responsible responsible ADJ njb-44 6 43 for for ADP njb-44 6 44 the the DET njb-44 6 45 activation activation NOUN njb-44 6 46 of of ADP njb-44 6 47 t t NOUN njb-44 6 48 cells cell NOUN njb-44 6 49 when when SCONJ njb-44 6 50 infectious infectious ADJ njb-44 6 51 agent agent NOUN njb-44 6 52 is be AUX njb-44 6 53 presented present VERB njb-44 6 54 by by ADP njb-44 6 55 an an DET njb-44 6 56 antigen antigen NOUN njb-44 6 57 presenting present VERB njb-44 6 58 cell cell NOUN njb-44 6 59 ( ( PUNCT njb-44 6 60 apc apc NOUN njb-44 6 61 ) ) PUNCT njb-44 6 62 in in ADP njb-44 6 63 the the DET njb-44 6 64 form form NOUN njb-44 6 65 of of ADP njb-44 6 66 peptides peptide NOUN njb-44 6 67 bound bind VERB njb-44 6 68 to to ADP njb-44 6 69 the the DET njb-44 6 70 major major ADJ njb-44 6 71 histocompatibility histocompatibility NOUN njb-44 6 72 complex complex NOUN njb-44 6 73 ( ( PUNCT njb-44 6 74 pmhc pmhc NOUN njb-44 6 75 ) ) PUNCT njb-44 6 76 . . PUNCT njb-44 7 1 despite despite SCONJ njb-44 7 2 numerous numerous ADJ njb-44 7 3 studies study NOUN njb-44 7 4 it it PRON njb-44 7 5 is be AUX njb-44 7 6 not not PART njb-44 7 7 clear clear ADJ njb-44 7 8 what what PRON njb-44 7 9 biochemical biochemical ADJ njb-44 7 10 changes change NOUN njb-44 7 11 upon upon SCONJ njb-44 7 12 binding bind VERB njb-44 7 13 of of ADP njb-44 7 14 antigen antigen NOUN njb-44 7 15 ligand ligand NOUN njb-44 7 16 to to ADP njb-44 7 17 the the DET njb-44 7 18 extracellular extracellular ADJ njb-44 7 19 domains domain NOUN njb-44 7 20 of of ADP njb-44 7 21 tcr tcr PROPN njb-44 7 22 leads lead VERB njb-44 7 23 to to ADP njb-44 7 24 activation activation NOUN njb-44 7 25 of of ADP njb-44 7 26 intracellular intracellular ADJ njb-44 7 27 signaling signaling NOUN njb-44 7 28 ( ( PUNCT njb-44 7 29 a a DET njb-44 7 30 process process NOUN njb-44 7 31 known know VERB njb-44 7 32 as as ADP njb-44 7 33 tcr tcr PROPN njb-44 7 34 triggering trigger VERB njb-44 7 35 ) ) PUNCT njb-44 7 36 . . PUNCT njb-44 8 1 this this DET njb-44 8 2 review review NOUN njb-44 8 3 summarizes summarize VERB njb-44 8 4 possible possible ADJ njb-44 8 5 biochemical biochemical ADJ njb-44 8 6 mechanisms mechanism NOUN njb-44 8 7 for for ADP njb-44 8 8 tcr tcr PROPN njb-44 8 9 triggering trigger VERB njb-44 8 10 and and CCONJ njb-44 8 11 discusses discuss VERB njb-44 8 12 their their PRON njb-44 8 13 comparative comparative ADJ njb-44 8 14 limitations limitation NOUN njb-44 8 15 and and CCONJ njb-44 8 16 advantages advantage NOUN njb-44 8 17 in in ADP njb-44 8 18 explaining explain VERB njb-44 8 19 various various ADJ njb-44 8 20 experimental experimental ADJ njb-44 8 21 observations observation NOUN njb-44 8 22 . . PUNCT njb-44 9 1 keywords keyword NOUN njb-44 9 2 : : PUNCT njb-44 9 3 t t PROPN njb-44 9 4 cell cell NOUN njb-44 9 5 antigen antigen PROPN njb-44 9 6 receptor receptor NOUN njb-44 9 7 , , PUNCT njb-44 9 8 activation activation NOUN njb-44 9 9 , , PUNCT njb-44 9 10 model model NOUN njb-44 9 11 introduction introduction NOUN njb-44 9 12 t t PROPN njb-44 9 13 cell cell PROPN njb-44 9 14 antigen antigen PROPN njb-44 9 15 receptor receptor NOUN njb-44 9 16 ( ( PUNCT njb-44 9 17 tcr tcr PROPN njb-44 9 18 or or CCONJ njb-44 9 19 tcr tcr PROPN njb-44 9 20 - - PUNCT njb-44 9 21 cd3 cd3 PROPN njb-44 9 22 ) ) PUNCT njb-44 9 23 is be AUX njb-44 9 24 a a DET njb-44 9 25 protein protein NOUN njb-44 9 26 complex complex NOUN njb-44 9 27 expressed express VERB njb-44 9 28 exclusively exclusively ADV njb-44 9 29 in in ADP njb-44 9 30 t t NOUN njb-44 9 31 cells cell NOUN njb-44 9 32 and and CCONJ njb-44 9 33 is be AUX njb-44 9 34 composed compose VERB njb-44 9 35 of of ADP njb-44 9 36 the the DET njb-44 9 37 variable variable NOUN njb-44 9 38 tcr tcr PROPN njb-44 9 39 α α PROPN njb-44 9 40 and and CCONJ njb-44 9 41 β β PROPN njb-44 9 42 chains chain NOUN njb-44 9 43 and and CCONJ njb-44 9 44 the the DET njb-44 9 45 constant constant ADJ njb-44 9 46 cd3γ cd3γ NOUN njb-44 9 47 , , PUNCT njb-44 9 48 cd3δ cd3δ PROPN njb-44 9 49 , , PUNCT njb-44 9 50 cd3ε cd3ε PROPN njb-44 9 51 and and CCONJ njb-44 9 52 cd3ζ cd3ζ NUM njb-44 9 53 chains chain NOUN njb-44 9 54 ( ( PUNCT njb-44 9 55 figure figure NOUN njb-44 9 56 1 1 NUM njb-44 9 57 ) ) PUNCT njb-44 9 58 . . PUNCT njb-44 10 1 cd3γ cd3γ NOUN njb-44 10 2 and and CCONJ njb-44 10 3 cd3δ cd3δ PROPN njb-44 10 4 chain chain NOUN njb-44 10 5 are be AUX njb-44 10 6 glycoproteins glycoprotein NOUN njb-44 10 7 each each PRON njb-44 10 8 of of ADP njb-44 10 9 which which PRON njb-44 10 10 form form VERB njb-44 10 11 a a DET njb-44 10 12 heterodimer heterodimer NOUN njb-44 10 13 with with ADP njb-44 10 14 non non ADJ njb-44 10 15 - - ADJ njb-44 10 16 glycosylated glycosylated ADJ njb-44 10 17 cd3ε cd3ε PROPN njb-44 10 18 chain chain NOUN njb-44 10 19 . . PUNCT njb-44 11 1 along along ADP njb-44 11 2 with with ADP njb-44 11 3 the the DET njb-44 11 4 cd3ζ cd3ζ PUNCT njb-44 11 5 - - PUNCT njb-44 11 6 ζ ζ NOUN njb-44 11 7 homodimer homodimer NOUN njb-44 11 8 , , PUNCT njb-44 11 9 these these DET njb-44 11 10 chains chain NOUN njb-44 11 11 associate associate VERB njb-44 11 12 with with ADP njb-44 11 13 the the DET njb-44 11 14 tcrαβ tcrαβ NOUN njb-44 11 15 heterodimer heterodimer NOUN njb-44 11 16 to to PART njb-44 11 17 generate generate VERB njb-44 11 18 the the DET njb-44 11 19 full full ADJ njb-44 11 20 tcrcd3 tcrcd3 PROPN njb-44 11 21 complex complex NOUN njb-44 12 1 [ [ X njb-44 12 2 1 1 NUM njb-44 12 3 ] ] PUNCT njb-44 12 4 . . PUNCT njb-44 13 1 the the DET njb-44 13 2 tcr tcr PROPN njb-44 13 3 - - PUNCT njb-44 13 4 cd3 cd3 PROPN njb-44 13 5 is be AUX njb-44 13 6 responsible responsible ADJ njb-44 13 7 for for ADP njb-44 13 8 activation activation NOUN njb-44 13 9 of of ADP njb-44 13 10 a a DET njb-44 13 11 t t NOUN njb-44 13 12 cell cell NOUN njb-44 13 13 upon upon SCONJ njb-44 13 14 antigen antigen NOUN njb-44 13 15 encounter encounter NOUN njb-44 13 16 which which PRON njb-44 13 17 then then ADV njb-44 13 18 help help VERB njb-44 13 19 in in ADP njb-44 13 20 the the DET njb-44 13 21 activation activation NOUN njb-44 13 22 of of ADP njb-44 13 23 b b NOUN njb-44 13 24 cells cell NOUN njb-44 13 25 by by ADP njb-44 13 26 releasing release VERB njb-44 13 27 helper helper NOUN njb-44 13 28 cytokines cytokine NOUN njb-44 13 29 ( ( PUNCT njb-44 13 30 helper helper VERB njb-44 13 31 t t PROPN njb-44 13 32 cells cell NOUN njb-44 13 33 ) ) PUNCT njb-44 13 34 or or CCONJ njb-44 13 35 kill kill VERB njb-44 13 36 the the DET njb-44 13 37 target target NOUN njb-44 13 38 cell cell NOUN njb-44 13 39 directly directly ADV njb-44 13 40 by by ADP njb-44 13 41 the the DET njb-44 13 42 secretion secretion NOUN njb-44 13 43 of of ADP njb-44 13 44 cytotoxic cytotoxic ADJ njb-44 13 45 effector effector NOUN njb-44 13 46 molecules molecule NOUN njb-44 13 47 such such ADJ njb-44 13 48 as as ADP njb-44 13 49 granzymes granzyme NOUN njb-44 13 50 , , PUNCT njb-44 13 51 perforin perforin NOUN njb-44 13 52 and and CCONJ njb-44 13 53 granulysin granulysin NOUN njb-44 13 54 . . PUNCT njb-44 14 1 antigenic antigenic ADJ njb-44 14 2 ligand ligand NOUN njb-44 14 3 binding bind VERB njb-44 14 4 to to ADP njb-44 14 5 the the DET njb-44 14 6 tcr tcr PROPN njb-44 14 7 leads lead VERB njb-44 14 8 to to ADP njb-44 14 9 the the DET njb-44 14 10 phosphorylation phosphorylation NOUN njb-44 14 11 of of ADP njb-44 14 12 immunoreceptor immunoreceptor ADJ njb-44 14 13 nepal nepal ADJ njb-44 14 14     SPACE njb-44 14 15 journal journal NOUN njb-44 14 16     SPACE njb-44 14 17 of of ADP njb-44 14 18     SPACE njb-44 14 19 biotechnology biotechnology NOUN njb-44 14 20 . . PUNCT njb-44 14 21         SPACE njb-44 15 1 jan jan PROPN njb-44 15 2     SPACE njb-44 15 3 2012 2012 NUM njb-44 15 4 , , PUNCT njb-44 15 5     SPACE njb-44 15 6 vol vol NOUN njb-44 15 7 . . PUNCT njb-44 15 8     SPACE njb-44 16 1 2 2 NUM njb-44 16 2 , , PUNCT njb-44 16 3     SPACE njb-44 16 4 no no INTJ njb-44 16 5 . . PUNCT njb-44 16 6     SPACE njb-44 17 1 1 1 NUM njb-44 17 2 : : PUNCT njb-44 17 3     SPACE njb-44 17 4 62 62 NUM njb-44 17 5     SPACE njb-44 17 6 – – PUNCT njb-44 17 7     SPACE njb-44 17 8 71 71 NUM njb-44 17 9                                                                                                                                                                                                                                         SPACE njb-44 17 10 biotechnology biotechnology NOUN njb-44 17 11     SPACE njb-44 17 12 society society NOUN njb-44 17 13     SPACE njb-44 17 14 of of ADP njb-44 17 15     SPACE njb-44 17 16 nepal nepal NOUN njb-44 17 17     SPACE njb-44 17 18 ( ( PUNCT njb-44 17 19 bsn bsn PROPN njb-44 17 20 ) ) PUNCT njb-44 17 21 , , PUNCT njb-44 17 22     SPACE njb-44 17 23 all all DET njb-44 17 24     SPACE njb-44 17 25 rights right NOUN njb-44 17 26     SPACE njb-44 17 27 reserved reserve VERB njb-44 17 28     SPACE njb-44 17 29 63 63 NUM njb-44 17 30 tyrosine tyrosine NOUN njb-44 17 31 - - PUNCT njb-44 17 32 based base VERB njb-44 17 33 activation activation NOUN njb-44 17 34 motifs motif NOUN njb-44 17 35 ( ( PUNCT njb-44 17 36 itams itams PROPN njb-44 17 37 ) ) PUNCT njb-44 17 38 of of ADP njb-44 17 39 the the DET njb-44 17 40 cd3 cd3 PROPN njb-44 17 41 complex complex NOUN njb-44 17 42 by by ADP njb-44 17 43 the the DET njb-44 17 44 src src NOUN njb-44 17 45 family family NOUN njb-44 17 46 protein protein NOUN njb-44 17 47 tyrosine tyrosine NOUN njb-44 17 48 kinase kinase NOUN njb-44 17 49 lck lck NOUN njb-44 17 50 , , PUNCT njb-44 17 51 resulting result VERB njb-44 17 52 in in ADP njb-44 17 53 the the DET njb-44 17 54 membrane membrane NOUN njb-44 17 55 targeting targeting NOUN njb-44 17 56 and and CCONJ njb-44 17 57 activation activation NOUN njb-44 17 58 of of ADP njb-44 17 59 another another DET njb-44 17 60 kinase kinase NOUN njb-44 17 61 , , PUNCT njb-44 17 62 zap-70 zap-70 PROPN njb-44 17 63 . . PUNCT njb-44 17 64 once once ADV njb-44 17 65 activated activate VERB njb-44 17 66 , , PUNCT njb-44 17 67 zap-70 zap-70 PUNCT njb-44 17 68 phosphorylates phosphorylate VERB njb-44 17 69 several several ADJ njb-44 17 70 substrates substrate NOUN njb-44 17 71 , , PUNCT njb-44 17 72 including include VERB njb-44 17 73 the the DET njb-44 17 74 transmembrane transmembrane ADJ njb-44 17 75 adaptor adaptor NOUN njb-44 17 76 protein protein NOUN njb-44 17 77 , , PUNCT njb-44 17 78 linker linker VERB njb-44 17 79 for for ADP njb-44 17 80 activation activation NOUN njb-44 17 81 of of ADP njb-44 17 82 t t NOUN njb-44 17 83 cells cell NOUN njb-44 17 84 ( ( PUNCT njb-44 17 85 lat lat PROPN njb-44 17 86 ) ) PUNCT njb-44 17 87 . . PUNCT njb-44 18 1 phospho phospho NOUN njb-44 18 2 - - PUNCT njb-44 18 3 lat lat NOUN njb-44 18 4 serves serve VERB njb-44 18 5 as as ADP njb-44 18 6 an an DET njb-44 18 7 important important ADJ njb-44 18 8 point point NOUN njb-44 18 9 of of ADP njb-44 18 10 divergence divergence NOUN njb-44 18 11 for for ADP njb-44 18 12 signals signal NOUN njb-44 18 13 initiated initiate VERB njb-44 18 14 from from ADP njb-44 18 15 the the DET njb-44 18 16 tcr tcr PROPN njb-44 18 17 by by ADP njb-44 18 18 recruiting recruit VERB njb-44 18 19 several several ADJ njb-44 18 20 effector effector NOUN njb-44 18 21 molecules molecule NOUN njb-44 18 22 to to ADP njb-44 18 23 the the DET njb-44 18 24 plasma plasma NOUN njb-44 18 25 membrane membrane NOUN njb-44 18 26 thus thus ADV njb-44 18 27 initiating initiate VERB njb-44 18 28 multiple multiple ADJ njb-44 18 29 pathways pathway NOUN njb-44 18 30 essential essential ADJ njb-44 18 31 for for ADP njb-44 18 32 full full ADJ njb-44 18 33 t t NOUN njb-44 18 34 cell cell NOUN njb-44 18 35 activation activation NOUN njb-44 18 36 [ [ X njb-44 18 37 2 2 NUM njb-44 18 38 ] ] PUNCT njb-44 18 39 . . PUNCT njb-44 18 40 ! ! PUNCT njb-44 18 41 " " PUNCT njb-44 19 1 # # SYM njb-44 19 2 $ $ SYM njb-44 19 3 % % NOUN njb-44 19 4 & & CCONJ njb-44 19 5 ' ' PROPN njb-44 19 6 & & CCONJ njb-44 19 7 # # NOUN njb-44 19 8 + + ADJ njb-44 19 9 + + NOUN njb-44 19 10 + + CCONJ njb-44 19 11 -itam -itam NOUN njb-44 19 12 -v -v PUNCT njb-44 20 1 c c X njb-44 20 2 v v X njb-44 20 3 c c X njb-44 20 4 - - PUNCT njb-44 20 5 fig.1 fig.1 ADJ njb-44 20 6 : : PUNCT njb-44 20 7 the the DET njb-44 20 8 tcr tcr PROPN njb-44 20 9 - - PUNCT njb-44 20 10 cd3 cd3 PROPN njb-44 20 11 complex complex NOUN njb-44 20 12 . . PUNCT njb-44 21 1 v v NOUN njb-44 21 2 and and CCONJ njb-44 21 3 c c NOUN njb-44 21 4 represent represent VERB njb-44 21 5 variable variable ADJ njb-44 21 6 and and CCONJ njb-44 21 7 constant constant ADJ njb-44 21 8 domains domain NOUN njb-44 21 9 respectively respectively ADV njb-44 21 10 for for ADP njb-44 21 11 the the DET njb-44 21 12 tcr tcr PROPN njb-44 21 13 α α PROPN njb-44 21 14 and and CCONJ njb-44 21 15 β β PROPN njb-44 21 16 . . PUNCT njb-44 22 1 the the DET njb-44 22 2 hypervariable hypervariable ADJ njb-44 22 3 region region NOUN njb-44 22 4 that that PRON njb-44 22 5 binds bind VERB njb-44 22 6 to to ADP njb-44 22 7 the the DET njb-44 22 8 pmhc pmhc NOUN njb-44 22 9 complex complex NOUN njb-44 22 10 is be AUX njb-44 22 11 shown show VERB njb-44 22 12 in in ADP njb-44 22 13 red red ADJ njb-44 22 14 color color NOUN njb-44 22 15 . . PUNCT njb-44 23 1 although although SCONJ njb-44 23 2 the the DET njb-44 23 3 downstream downstream ADJ njb-44 23 4 signaling signal VERB njb-44 23 5 mechanisms mechanism NOUN njb-44 23 6 of of ADP njb-44 23 7 t t NOUN njb-44 23 8 cell cell NOUN njb-44 23 9 activation activation NOUN njb-44 23 10 have have AUX njb-44 23 11 been be AUX njb-44 23 12 explored explore VERB njb-44 23 13 to to ADP njb-44 23 14 quite quite ADV njb-44 23 15 detailed detailed ADJ njb-44 23 16 extent extent NOUN njb-44 23 17 , , PUNCT njb-44 23 18 the the DET njb-44 23 19 basic basic ADJ njb-44 23 20 mechanism mechanism NOUN njb-44 23 21 of of ADP njb-44 23 22 how how SCONJ njb-44 23 23 ligand ligand NOUN njb-44 23 24 binding bind VERB njb-44 23 25 to to ADP njb-44 23 26 extracellular extracellular ADJ njb-44 23 27 domains domain NOUN njb-44 23 28 of of ADP njb-44 23 29 tcrαβ tcrαβ NOUN njb-44 23 30 leads lead VERB njb-44 23 31 to to ADP njb-44 23 32 downstream downstream ADJ njb-44 23 33 signaling signaling NOUN njb-44 23 34 remained remain VERB njb-44 23 35 unclear unclear ADJ njb-44 23 36 . . PUNCT njb-44 24 1 several several ADJ njb-44 24 2 models model NOUN njb-44 24 3 of of ADP njb-44 24 4 tcr tcr PROPN njb-44 24 5 triggering trigger VERB njb-44 24 6 have have AUX njb-44 24 7 been be AUX njb-44 24 8 proposed propose VERB njb-44 24 9 based base VERB njb-44 24 10 on on ADP njb-44 24 11 the the DET njb-44 24 12 experimental experimental ADJ njb-44 24 13 findings finding NOUN njb-44 24 14 , , PUNCT njb-44 24 15 but but CCONJ njb-44 24 16 none none NOUN njb-44 24 17 of of ADP njb-44 24 18 the the DET njb-44 24 19 models model NOUN njb-44 24 20 so so ADV njb-44 24 21 far far ADV njb-44 24 22 could could AUX njb-44 24 23 explain explain VERB njb-44 24 24 every every DET njb-44 24 25 aspect aspect NOUN njb-44 24 26 of of ADP njb-44 24 27 tcr tcr PROPN njb-44 24 28 triggering trigger VERB njb-44 24 29 . . PUNCT njb-44 25 1 broadly broadly ADV njb-44 25 2 , , PUNCT njb-44 25 3 these these DET njb-44 25 4 models model NOUN njb-44 25 5 can can AUX njb-44 25 6 be be AUX njb-44 25 7 grouped group VERB njb-44 25 8 in in ADP njb-44 25 9 three three NUM njb-44 25 10 major major ADJ njb-44 25 11 processes process NOUN njb-44 25 12 which which PRON njb-44 25 13 involve involve VERB njb-44 25 14 aggregation aggregation NOUN njb-44 25 15 , , PUNCT njb-44 25 16 conformational conformational ADJ njb-44 25 17 change change NOUN njb-44 25 18 or or CCONJ njb-44 25 19 segregation segregation NOUN njb-44 25 20 ( ( PUNCT njb-44 25 21 figure figure NOUN njb-44 25 22 2 2 NUM njb-44 25 23 ) ) PUNCT njb-44 25 24 . . PUNCT njb-44 26 1 this this DET njb-44 26 2 review review NOUN njb-44 26 3 summarizes summarize VERB njb-44 26 4 the the DET njb-44 26 5 proposed propose VERB njb-44 26 6 models model NOUN njb-44 26 7 of of ADP njb-44 26 8 tcr tcr PROPN njb-44 26 9 triggering trigger VERB njb-44 26 10 and and CCONJ njb-44 26 11 discusses discuss VERB njb-44 26 12 their their PRON njb-44 26 13 comparative comparative ADJ njb-44 26 14 abilities ability NOUN njb-44 26 15 for for ADP njb-44 26 16 explaining explain VERB njb-44 26 17 various various ADJ njb-44 26 18 experimental experimental ADJ njb-44 26 19 observations observation NOUN njb-44 26 20 ( ( PUNCT njb-44 26 21 table table NOUN njb-44 26 22 1 1 NUM njb-44 26 23 ) ) PUNCT njb-44 26 24 . . PUNCT njb-44 27 1 1 1 X njb-44 27 2 . . X njb-44 27 3 antigen antigen PROPN njb-44 27 4 induced induce VERB njb-44 27 5 clustering cluster VERB njb-44 27 6 several several ADJ njb-44 27 7 forms form NOUN njb-44 27 8 of of ADP njb-44 27 9 clustering clustering NOUN njb-44 27 10 have have AUX njb-44 27 11 been be AUX njb-44 27 12 proposed propose VERB njb-44 27 13 as as ADP njb-44 27 14 the the DET njb-44 27 15 triggering trigger VERB njb-44 27 16 mechanism mechanism NOUN njb-44 27 17 for for ADP njb-44 27 18 the the DET njb-44 27 19 tcr tcr PROPN njb-44 27 20 . . PUNCT njb-44 28 1 these these PRON njb-44 28 2 include include VERB njb-44 28 3 homodimer homodimer NOUN njb-44 28 4 , , PUNCT njb-44 28 5 heterodimer heterodimer PROPN njb-44 28 6 and and CCONJ njb-44 28 7 the the DET njb-44 28 8 pseudodimer pseudodimer NOUN njb-44 28 9 models model NOUN njb-44 28 10 as as SCONJ njb-44 28 11 discussed discuss VERB njb-44 28 12 below below ADP njb-44 28 13 . . PUNCT njb-44 29 1 nepal nepal ADJ njb-44 29 2     SPACE njb-44 29 3 journal journal NOUN njb-44 29 4     SPACE njb-44 29 5 of of ADP njb-44 29 6     SPACE njb-44 29 7 biotechnology biotechnology NOUN njb-44 29 8 . . PUNCT njb-44 29 9         SPACE njb-44 30 1 jan jan PROPN njb-44 30 2     SPACE njb-44 30 3 2012 2012 NUM njb-44 30 4 , , PUNCT njb-44 30 5     SPACE njb-44 30 6 vol vol NOUN njb-44 30 7 . . PUNCT njb-44 30 8     SPACE njb-44 31 1 2 2 NUM njb-44 31 2 , , PUNCT njb-44 31 3     SPACE njb-44 31 4 no no INTJ njb-44 31 5 . . PUNCT njb-44 31 6     SPACE njb-44 32 1 1 1 NUM njb-44 32 2 : : PUNCT njb-44 32 3     SPACE njb-44 32 4 62 62 NUM njb-44 32 5     SPACE njb-44 32 6 – – PUNCT njb-44 32 7     SPACE njb-44 32 8 71 71 NUM njb-44 32 9                                                                                                                                                                                                                                         SPACE njb-44 32 10 biotechnology biotechnology NOUN njb-44 32 11     SPACE njb-44 32 12 society society NOUN njb-44 32 13     SPACE njb-44 32 14 of of ADP njb-44 32 15     SPACE njb-44 32 16 nepal nepal NOUN njb-44 32 17     SPACE njb-44 32 18 ( ( PUNCT njb-44 32 19 bsn bsn PROPN njb-44 32 20 ) ) PUNCT njb-44 32 21 , , PUNCT njb-44 32 22     SPACE njb-44 32 23 all all DET njb-44 32 24     SPACE njb-44 32 25 rights right NOUN njb-44 32 26     SPACE njb-44 32 27 reserved reserve VERB njb-44 32 28     SPACE njb-44 32 29 64 64 NUM njb-44 32 30 b b X njb-44 32 31 c c X njb-44 32 32 d d X njb-44 32 33 e e PROPN njb-44 32 34 f f PROPN njb-44 32 35 lck lck PROPN njb-44 32 36 tcr tcr PROPN njb-44 32 37 pmhc pmhc PROPN njb-44 32 38 lck lck PROPN njb-44 32 39 lcklck lcklck PROPN njb-44 32 40 binding binding PROPN njb-44 32 41 tcr tcr PROPN njb-44 32 42 lck lck PROPN njb-44 32 43 cd45 cd45 PROPN njb-44 32 44 pmhc pmhc PROPN njb-44 32 45 lck lck PROPN njb-44 32 46 lck lck PROPN njb-44 32 47 lck lck PROPN njb-44 32 48 lcklck lcklck PROPN njb-44 32 49 binding bind VERB njb-44 32 50 lipid lipid NOUN njb-44 32 51 raft raft PROPN njb-44 32 52 lck lck PROPN njb-44 32 53 tcr tcr PROPN njb-44 32 54 pmhc pmhc PROPN njb-44 32 55 co co NOUN njb-44 32 56 - - NOUN njb-44 32 57 receptor receptor PROPN njb-44 32 58 lck lck PROPN njb-44 32 59 tcr tcr PROPN njb-44 32 60 pmhc pmhc PROPN njb-44 32 61 lck lck PROPN njb-44 32 62 tcr tcr PROPN njb-44 32 63 pmhc pmhc PROPN njb-44 32 64 lcklck lcklck PROPN njb-44 32 65 cd45 cd45 PROPN njb-44 32 66 tcr tcr PROPN njb-44 32 67 pmhc pmhc PROPN njb-44 32 68 binding binding PROPN njb-44 32 69 ! ! PUNCT njb-44 33 1 lck lck PROPN njb-44 33 2 lck lck PROPN njb-44 33 3 tcr tcr PROPN njb-44 33 4 pmhc pmhc PROPN njb-44 33 5 lck lck PROPN njb-44 33 6 pullbinding pullbinding PROPN njb-44 33 7 tcr tcr PROPN njb-44 33 8 pmhc pmhc PROPN njb-44 33 9 binding bind VERB njb-44 33 10 a a DET njb-44 33 11 g g X njb-44 33 12 h h NUM njb-44 33 13 clustering cluster VERB njb-44 33 14 models model NOUN njb-44 33 15 conformational conformational ADJ njb-44 33 16 change change NOUN njb-44 33 17 models model NOUN njb-44 33 18 segregation segregation NOUN njb-44 33 19 models model NOUN njb-44 33 20 fig.2 fig.2 PROPN njb-44 33 21 : : PUNCT njb-44 33 22 various various ADJ njb-44 33 23 models model NOUN njb-44 33 24 of of ADP njb-44 33 25 tcr tcr PROPN njb-44 33 26 triggering trigger VERB njb-44 33 27 . . PUNCT njb-44 34 1 a a X njb-44 34 2 ) ) PUNCT njb-44 34 3 homodimer homodimer NOUN njb-44 34 4 model model NOUN njb-44 34 5 , , PUNCT njb-44 34 6 b b NOUN njb-44 34 7 ) ) PUNCT njb-44 34 8 heterodimer heterodimer NOUN njb-44 34 9 model model PROPN njb-44 34 10 , , PUNCT njb-44 34 11 c c PROPN njb-44 34 12 ) ) PUNCT njb-44 34 13 pseudo pseudo ADJ njb-44 34 14 - - PUNCT njb-44 34 15 dimer dimer NOUN njb-44 34 16 model model NOUN njb-44 34 17 , , PUNCT njb-44 34 18 d d NOUN njb-44 34 19 ) ) PUNCT njb-44 34 20 membrane membrane NOUN njb-44 34 21 binding bind VERB njb-44 34 22 model model NOUN njb-44 34 23 , , PUNCT njb-44 34 24 e e NOUN njb-44 34 25 ) ) PUNCT njb-44 34 26 kinetic kinetic ADJ njb-44 34 27 deformation deformation NOUN njb-44 34 28 model model NOUN njb-44 34 29 , , PUNCT njb-44 34 30 f f X njb-44 34 31 ) ) PUNCT njb-44 34 32 permissive permissive ADJ njb-44 34 33 geometry geometry NOUN njb-44 34 34 model model NOUN njb-44 34 35 , , PUNCT njb-44 34 36 g g X njb-44 34 37 ) ) PUNCT njb-44 34 38 kinetic kinetic PROPN njb-44 34 39 segregation segregation NOUN njb-44 34 40 , , PUNCT njb-44 34 41 h h X njb-44 34 42 ) ) PUNCT njb-44 34 43 lipid lipid ADJ njb-44 34 44 raft raft NOUN njb-44 34 45 mediated mediate VERB njb-44 34 46 segregation segregation NOUN njb-44 34 47 model model NOUN njb-44 34 48 . . PUNCT njb-44 35 1 full full ADJ njb-44 35 2 description description NOUN njb-44 35 3 of of ADP njb-44 35 4 each each DET njb-44 35 5 model model NOUN njb-44 35 6 is be AUX njb-44 35 7 given give VERB njb-44 35 8 in in ADP njb-44 35 9 the the DET njb-44 35 10 main main ADJ njb-44 35 11 text text NOUN njb-44 35 12 . . PUNCT njb-44 36 1 nepal nepal ADJ njb-44 36 2     SPACE njb-44 36 3 journal journal NOUN njb-44 36 4     SPACE njb-44 36 5 of of ADP njb-44 36 6     SPACE njb-44 36 7 biotechnology biotechnology NOUN njb-44 36 8 . . PUNCT njb-44 36 9         SPACE njb-44 37 1 jan jan PROPN njb-44 37 2     SPACE njb-44 37 3 2012 2012 NUM njb-44 37 4 , , PUNCT njb-44 37 5     SPACE njb-44 37 6 vol vol NOUN njb-44 37 7 . . PUNCT njb-44 37 8     SPACE njb-44 38 1 2 2 NUM njb-44 38 2 , , PUNCT njb-44 38 3     SPACE njb-44 38 4 no no INTJ njb-44 38 5 . . PUNCT njb-44 38 6     SPACE njb-44 39 1 1 1 NUM njb-44 39 2 : : PUNCT njb-44 39 3     SPACE njb-44 39 4 62 62 NUM njb-44 39 5     SPACE njb-44 39 6 – – PUNCT njb-44 39 7     SPACE njb-44 39 8 71 71 NUM njb-44 39 9                                                                                                                                                                                                                                         SPACE njb-44 39 10 biotechnology biotechnology NOUN njb-44 39 11     SPACE njb-44 39 12 society society NOUN njb-44 39 13     SPACE njb-44 39 14 of of ADP njb-44 39 15     SPACE njb-44 39 16 nepal nepal NOUN njb-44 39 17     SPACE njb-44 39 18 ( ( PUNCT njb-44 39 19 bsn bsn PROPN njb-44 39 20 ) ) PUNCT njb-44 39 21 , , PUNCT njb-44 39 22     SPACE njb-44 39 23 all all DET njb-44 39 24     SPACE njb-44 39 25 rights right NOUN njb-44 39 26     SPACE njb-44 39 27 reserved reserve VERB njb-44 39 28     SPACE njb-44 39 29 65 65 NUM njb-44 39 30 table table NOUN njb-44 39 31 1 1 NUM njb-44 39 32 : : PUNCT njb-44 39 33 abilities ability NOUN njb-44 39 34 of of ADP njb-44 39 35 different different ADJ njb-44 39 36 models model NOUN njb-44 39 37 to to PART njb-44 39 38 explain explain VERB njb-44 39 39 various various ADJ njb-44 39 40 experimental experimental ADJ njb-44 39 41 observations observation NOUN njb-44 39 42 . . PUNCT njb-44 40 1 observation observation NOUN njb-44 40 2         SPACE njb-44 40 3 triggering trigger VERB njb-44 40 4     SPACE njb-44 40 5 model model NOUN njb-44 40 6             SPACE njb-44 40 7 homodimer homodimer NOUN njb-44 40 8     SPACE njb-44 40 9 heterodimer heterodimer NOUN njb-44 40 10     SPACE njb-44 40 11 pseudodimer pseudodimer NOUN njb-44 40 12     SPACE njb-44 40 13 membrane membrane NOUN njb-44 40 14 binding bind VERB njb-44 40 15     SPACE njb-44 40 16 kinetic kinetic ADJ njb-44 40 17 deformation deformation NOUN njb-44 40 18     SPACE njb-44 40 19 permissive permissive ADJ njb-44 40 20 geometry geometry NOUN njb-44 40 21     SPACE njb-44 40 22 kinetic kinetic NOUN njb-44 40 23 segregation segregation NOUN njb-44 40 24     SPACE njb-44 40 25 lipid lipid NOUN njb-44 40 26 raft raft NOUN njb-44 40 27     SPACE njb-44 40 28 pre-­‐clustered pre-­‐clustere VERB njb-44 40 29     SPACE njb-44 40 30 tcr tcr PROPN njb-44 40 31     SPACE njb-44 41 1 no no INTJ njb-44 41 2     SPACE njb-44 41 3 yes yes INTJ njb-44 41 4     SPACE njb-44 42 1 yes yes INTJ njb-44 42 2     SPACE njb-44 43 1 yes yes INTJ njb-44 43 2     SPACE njb-44 44 1 yes yes INTJ njb-44 44 2     SPACE njb-44 45 1 yes yes INTJ njb-44 45 2     SPACE njb-44 46 1 yes yes INTJ njb-44 46 2     SPACE njb-44 46 3 yes yes INTJ njb-44 46 4     SPACE njb-44 46 5 coreceptor coreceptor NOUN njb-44 46 6     SPACE njb-44 46 7 independent independent ADJ njb-44 46 8     SPACE njb-44 46 9 triggering trigger VERB njb-44 46 10     SPACE njb-44 46 11 yes yes INTJ njb-44 46 12     SPACE njb-44 46 13 no no PRON njb-44 46 14     SPACE njb-44 46 15 no no INTJ njb-44 46 16     SPACE njb-44 47 1 yes yes INTJ njb-44 47 2     SPACE njb-44 48 1 yes yes INTJ njb-44 48 2     SPACE njb-44 49 1 yes yes INTJ njb-44 49 2     SPACE njb-44 50 1 yes yes INTJ njb-44 50 2     SPACE njb-44 50 3 yes yes INTJ njb-44 50 4     SPACE njb-44 50 5 triggering trigger VERB njb-44 50 6     SPACE njb-44 50 7 by by ADP njb-44 50 8     SPACE njb-44 50 9 soluble soluble ADJ njb-44 50 10     SPACE njb-44 50 11 monomer monomer NOUN njb-44 50 12     SPACE njb-44 50 13 pmhc pmhc NOUN njb-44 50 14     SPACE njb-44 50 15 no no PRON njb-44 50 16     SPACE njb-44 50 17 yes yes INTJ njb-44 50 18     SPACE njb-44 51 1 no no INTJ njb-44 51 2     SPACE njb-44 51 3 yes yes INTJ njb-44 51 4     SPACE njb-44 52 1 no no PRON njb-44 52 2     SPACE njb-44 52 3 no no PRON njb-44 52 4     SPACE njb-44 52 5 no no INTJ njb-44 52 6     SPACE njb-44 53 1 yes yes INTJ njb-44 53 2     SPACE njb-44 53 3 triggering trigger VERB njb-44 53 4     SPACE njb-44 53 5 by by ADP njb-44 53 6     SPACE njb-44 53 7 anti-­‐cd3 anti-­‐cd3 PROPN njb-44 53 8     SPACE njb-44 53 9 antibodies antibody NOUN njb-44 53 10     SPACE njb-44 53 11 yes yes INTJ njb-44 53 12     SPACE njb-44 53 13 no no PRON njb-44 53 14     SPACE njb-44 53 15 no no INTJ njb-44 53 16     SPACE njb-44 54 1 yes yes INTJ njb-44 54 2     SPACE njb-44 54 3 no no INTJ njb-44 54 4     SPACE njb-44 54 5 yes yes INTJ njb-44 54 6     SPACE njb-44 54 7 no no DET njb-44 54 8     SPACE njb-44 54 9 no no DET njb-44 54 10     SPACE njb-44 54 11 activation activation NOUN njb-44 54 12     SPACE njb-44 54 13 by by ADP njb-44 54 14     SPACE njb-44 54 15 pervanadate pervanadate VERB njb-44 54 16     SPACE njb-44 54 17 no no DET njb-44 54 18     SPACE njb-44 54 19 no no DET njb-44 54 20     SPACE njb-44 54 21 no no DET njb-44 54 22     SPACE njb-44 54 23 no no DET njb-44 54 24     SPACE njb-44 54 25 no no PRON njb-44 54 26     SPACE njb-44 55 1 no no INTJ njb-44 55 2     SPACE njb-44 55 3 yes yes INTJ njb-44 55 4     SPACE njb-44 55 5 yes yes INTJ njb-44 55 6     SPACE njb-44 55 7 inhibition inhibition NOUN njb-44 55 8     SPACE njb-44 55 9 by by SCONJ njb-44 55 10     SPACE njb-44 55 11 truncated truncate VERB njb-44 55 12     SPACE njb-44 55 13 cd45 cd45 PROPN njb-44 55 14     SPACE njb-44 55 15 no no DET njb-44 55 16     SPACE njb-44 55 17 no no DET njb-44 55 18     SPACE njb-44 55 19 no no PRON njb-44 55 20     SPACE njb-44 55 21 no no PRON njb-44 55 22     SPACE njb-44 55 23 no no PRON njb-44 55 24     SPACE njb-44 55 25 no no INTJ njb-44 55 26     SPACE njb-44 56 1 yes yes INTJ njb-44 56 2     SPACE njb-44 56 3 no no DET njb-44 56 4         SPACE njb-44 56 5 inhibition inhibition NOUN njb-44 56 6     SPACE njb-44 56 7 by by ADP njb-44 56 8     SPACE njb-44 56 9 elongated elongate VERB njb-44 56 10     SPACE njb-44 56 11 pmhc pmhc NOUN njb-44 56 12     SPACE njb-44 56 13 no no DET njb-44 56 14     SPACE njb-44 56 15 no no PRON njb-44 56 16     SPACE njb-44 56 17 no no PRON njb-44 56 18     SPACE njb-44 56 19 no no PRON njb-44 56 20     SPACE njb-44 56 21 no no PRON njb-44 56 22     SPACE njb-44 57 1 no no INTJ njb-44 57 2     SPACE njb-44 57 3 yes yes INTJ njb-44 57 4     SPACE njb-44 57 5 no no DET njb-44 57 6         SPACE njb-44 57 7 triggering trigger VERB njb-44 57 8     SPACE njb-44 57 9 in in ADP njb-44 57 10     SPACE njb-44 57 11 absence absence NOUN njb-44 57 12     SPACE njb-44 57 13 of of ADP njb-44 57 14     SPACE njb-44 57 15 self self NOUN njb-44 57 16     SPACE njb-44 57 17 pmhc pmhc NOUN njb-44 57 18     SPACE njb-44 57 19 yes yes INTJ njb-44 57 20     SPACE njb-44 58 1 yes yes INTJ njb-44 58 2     SPACE njb-44 58 3 no no INTJ njb-44 58 4     SPACE njb-44 59 1 yes yes INTJ njb-44 59 2     SPACE njb-44 60 1 yes yes INTJ njb-44 60 2     SPACE njb-44 61 1 yes yes INTJ njb-44 61 2     SPACE njb-44 62 1 yes yes INTJ njb-44 62 2     SPACE njb-44 62 3 yes yes INTJ njb-44 62 4     SPACE njb-44 62 5 a. a. NOUN njb-44 62 6 homodimer homodimer NOUN njb-44 62 7 model model PROPN njb-44 62 8 clustering clustering PROPN njb-44 62 9 of of ADP njb-44 62 10 tcr tcr PROPN njb-44 62 11 – – PUNCT njb-44 62 12 cd3 cd3 PROPN njb-44 62 13 complexes complex NOUN njb-44 62 14 following follow VERB njb-44 62 15 tcr tcr PROPN njb-44 62 16 engagement engagement PROPN njb-44 62 17 could could AUX njb-44 62 18 lead lead VERB njb-44 62 19 to to ADP njb-44 62 20 enhanced enhance VERB njb-44 62 21 phosphorylation phosphorylation NOUN njb-44 62 22 , , PUNCT njb-44 62 23 for for ADP njb-44 62 24 example example NOUN njb-44 62 25 by by ADP njb-44 62 26 increasing increase VERB njb-44 62 27 the the DET njb-44 62 28 proximity proximity NOUN njb-44 62 29 of of ADP njb-44 62 30 associated associated ADJ njb-44 62 31 lck lck NOUN njb-44 62 32 molecules molecule NOUN njb-44 62 33 , , PUNCT njb-44 62 34 resulting result VERB njb-44 62 35 in in ADP njb-44 62 36 the the DET njb-44 62 37 activation activation NOUN njb-44 62 38 of of ADP njb-44 62 39 the the DET njb-44 62 40 second second ADJ njb-44 62 41 receptor receptor NOUN njb-44 62 42 in in ADP njb-44 62 43 the the DET njb-44 62 44 cluster cluster NOUN njb-44 62 45 by by ADP njb-44 62 46 transautophosphorylation transautophosphorylation NOUN njb-44 62 47 ( ( PUNCT njb-44 62 48 or or CCONJ njb-44 62 49 this this DET njb-44 62 50 enhanced enhance VERB njb-44 62 51 proximity proximity NOUN njb-44 62 52 of of ADP njb-44 62 53 kinases kinase NOUN njb-44 62 54 might might AUX njb-44 62 55 lead lead VERB njb-44 62 56 to to ADP njb-44 62 57 their their PRON njb-44 62 58 transphosphorylation transphosphorylation NOUN njb-44 62 59 which which PRON njb-44 62 60 enhance enhance VERB njb-44 62 61 their their PRON njb-44 62 62 activity activity NOUN njb-44 62 63 to to PART njb-44 62 64 phosphorylate phosphorylate VERB njb-44 62 65 the the DET njb-44 62 66 receptor receptor NOUN njb-44 62 67 ) ) PUNCT njb-44 62 68 . . PUNCT njb-44 63 1 this this DET njb-44 63 2 model model NOUN njb-44 63 3 is be AUX njb-44 63 4 supported support VERB njb-44 63 5 by by ADP njb-44 63 6 the the DET njb-44 63 7 observations observation NOUN njb-44 63 8 that that SCONJ njb-44 63 9 artificial artificial ADJ njb-44 63 10 ligands ligand NOUN njb-44 63 11 such such ADJ njb-44 63 12 as as ADP njb-44 63 13 pmhc pmhc NOUN njb-44 63 14 tetramer tetramer PROPN njb-44 63 15 and and CCONJ njb-44 63 16 the the DET njb-44 63 17 antitcrαβ antitcrαβ NOUN njb-44 63 18 and and CCONJ njb-44 63 19 anti anti ADJ njb-44 63 20 - - ADJ njb-44 63 21 cd3 cd3 ADJ njb-44 63 22 antibodies antibody NOUN njb-44 63 23 that that PRON njb-44 63 24 crosslink crosslink VERB njb-44 63 25 the the DET njb-44 63 26 tcr tcr PROPN njb-44 63 27 lead lead VERB njb-44 63 28 to to ADP njb-44 63 29 its its PRON njb-44 63 30 activation activation NOUN njb-44 63 31 whereas whereas SCONJ njb-44 63 32 fab fab PROPN njb-44 63 33 fragment fragment NOUN njb-44 63 34 of of ADP njb-44 63 35 these these DET njb-44 63 36 antibodies antibody NOUN njb-44 63 37 or or CCONJ njb-44 63 38 the the DET njb-44 63 39 monomeric monomeric NOUN njb-44 63 40 pmhc pmhc NOUN njb-44 63 41 in in ADP njb-44 63 42 solution solution NOUN njb-44 63 43 fail fail VERB njb-44 63 44 to to PART njb-44 63 45 activate activate VERB njb-44 63 46 the the DET njb-44 63 47 tcr tcr PROPN njb-44 64 1 [ [ X njb-44 64 2 3 3 NUM njb-44 64 3 ] ] X njb-44 64 4 . . PUNCT njb-44 65 1 also also ADV njb-44 65 2 the the DET njb-44 65 3 observations observation NOUN njb-44 65 4 that that PRON njb-44 65 5 mhc mhc ADJ njb-44 65 6 class class NOUN njb-44 65 7 i i PRON njb-44 66 1 [ [ PUNCT njb-44 66 2 4 4 NUM njb-44 66 3 , , PUNCT njb-44 66 4 5 5 NUM njb-44 66 5 ] ] PUNCT njb-44 66 6 and and CCONJ njb-44 66 7 mhc mhc PROPN njb-44 66 8 class class PROPN njb-44 66 9 ii ii PROPN njb-44 67 1 [ [ PUNCT njb-44 67 2 6 6 NUM njb-44 67 3 ] ] PUNCT njb-44 67 4 exist exist VERB njb-44 67 5 in in ADP njb-44 67 6 pre pre ADJ njb-44 67 7 - - ADJ njb-44 67 8 formed form VERB njb-44 67 9 clusters cluster NOUN njb-44 67 10 , , PUNCT njb-44 67 11 support support VERB njb-44 67 12 the the DET njb-44 67 13 homodimer homodimer NOUN njb-44 67 14 model model NOUN njb-44 67 15 . . PUNCT njb-44 68 1 however however ADV njb-44 68 2 , , PUNCT njb-44 68 3 since since SCONJ njb-44 68 4 several several ADJ njb-44 68 5 studies study NOUN njb-44 68 6 have have AUX njb-44 68 7 now now ADV njb-44 68 8 shown show VERB njb-44 68 9 the the DET njb-44 68 10 existence existence NOUN njb-44 68 11 of of ADP njb-44 68 12 pre pre ADJ njb-44 68 13 - - ADJ njb-44 68 14 clustered cluster VERB njb-44 68 15 tcrs tcrs NOUN njb-44 68 16 on on ADP njb-44 68 17 the the DET njb-44 68 18 t t PROPN njb-44 68 19 cell cell NOUN njb-44 68 20 surface surface NOUN njb-44 68 21 [ [ PUNCT njb-44 68 22 7 7 NUM njb-44 68 23 , , PUNCT njb-44 68 24 8 8 NUM njb-44 68 25 ] ] PUNCT njb-44 68 26 , , PUNCT njb-44 68 27 it it PRON njb-44 68 28 is be AUX njb-44 68 29 difficult difficult ADJ njb-44 68 30 to to PART njb-44 68 31 imagine imagine VERB njb-44 68 32 that that SCONJ njb-44 68 33 clustering cluster VERB njb-44 68 34 alone alone ADV njb-44 68 35 could could AUX njb-44 68 36 trigger trigger VERB njb-44 68 37 the the DET njb-44 68 38 nepal nepal ADJ njb-44 68 39     SPACE njb-44 68 40 journal journal NOUN njb-44 68 41     SPACE njb-44 68 42 of of ADP njb-44 68 43     SPACE njb-44 68 44 biotechnology biotechnology NOUN njb-44 68 45 . . PUNCT njb-44 68 46         SPACE njb-44 69 1 jan jan PROPN njb-44 69 2     SPACE njb-44 69 3 2012 2012 NUM njb-44 69 4 , , PUNCT njb-44 69 5     SPACE njb-44 69 6 vol vol NOUN njb-44 69 7 . . PUNCT njb-44 69 8     SPACE njb-44 70 1 2 2 NUM njb-44 70 2 , , PUNCT njb-44 70 3     SPACE njb-44 70 4 no no INTJ njb-44 70 5 . . PUNCT njb-44 70 6     SPACE njb-44 71 1 1 1 NUM njb-44 71 2 : : PUNCT njb-44 71 3     SPACE njb-44 71 4 62 62 NUM njb-44 71 5     SPACE njb-44 71 6 – – PUNCT njb-44 71 7     SPACE njb-44 71 8 71 71 NUM njb-44 71 9                                                                                                                                                                                                                                         SPACE njb-44 71 10 biotechnology biotechnology NOUN njb-44 71 11     SPACE njb-44 71 12 society society NOUN njb-44 71 13     SPACE njb-44 71 14 of of ADP njb-44 71 15     SPACE njb-44 71 16 nepal nepal NOUN njb-44 71 17     SPACE njb-44 71 18 ( ( PUNCT njb-44 71 19 bsn bsn PROPN njb-44 71 20 ) ) PUNCT njb-44 71 21 , , PUNCT njb-44 71 22     SPACE njb-44 71 23 all all DET njb-44 71 24     SPACE njb-44 71 25 rights right NOUN njb-44 71 26     SPACE njb-44 71 27 reserved reserve VERB njb-44 71 28     SPACE njb-44 71 29 66 66 NUM njb-44 71 30 tcr tcr PROPN njb-44 71 31 . . PUNCT njb-44 72 1 in in ADP njb-44 72 2 fact fact NOUN njb-44 72 3 in in ADP njb-44 72 4 a a DET njb-44 72 5 study study NOUN njb-44 72 6 by by ADP njb-44 72 7 schamel schamel PROPN njb-44 72 8 and and CCONJ njb-44 72 9 colleagues colleague NOUN njb-44 72 10 [ [ X njb-44 72 11 9 9 NUM njb-44 72 12 ] ] PUNCT njb-44 72 13 , , PUNCT njb-44 72 14 both both PRON njb-44 72 15 clustering clustering NOUN njb-44 72 16 and and CCONJ njb-44 72 17 conformational conformational ADJ njb-44 72 18 change change NOUN njb-44 72 19 were be AUX njb-44 72 20 shown show VERB njb-44 72 21 to to PART njb-44 72 22 be be AUX njb-44 72 23 required require VERB njb-44 72 24 for for ADP njb-44 72 25 tcr tcr PROPN njb-44 72 26 triggering trigger VERB njb-44 72 27 ( ( PUNCT njb-44 72 28 permissive permissive ADJ njb-44 72 29 geometry geometry NOUN njb-44 72 30 model model NOUN njb-44 72 31 , , PUNCT njb-44 72 32 as as SCONJ njb-44 72 33 discussed discuss VERB njb-44 72 34 later later ADV njb-44 72 35 ) ) PUNCT njb-44 72 36 . . PUNCT njb-44 73 1 b. b. PROPN njb-44 73 2 heterodimer heterodimer PROPN njb-44 73 3 model model PROPN njb-44 73 4 in in ADP njb-44 73 5 the the DET njb-44 73 6 heterodimer heterodimer NOUN njb-44 73 7 model model NOUN njb-44 74 1 [ [ X njb-44 74 2 10 10 NUM njb-44 74 3 ] ] PUNCT njb-44 74 4 , , PUNCT njb-44 74 5 coreceptor coreceptor PROPN njb-44 74 6 cd8 cd8 PROPN njb-44 74 7 or or CCONJ njb-44 74 8 cd4 cd4 X njb-44 74 9 binding bind VERB njb-44 74 10 to to ADP njb-44 74 11 the the DET njb-44 74 12 same same ADJ njb-44 74 13 pmhc pmhc NOUN njb-44 74 14 complex complex NOUN njb-44 74 15 as as SCONJ njb-44 74 16 the the DET njb-44 74 17 tcr tcr PROPN njb-44 74 18 brings bring VERB njb-44 74 19 the the DET njb-44 74 20 coreceptorassociated coreceptorassociate VERB njb-44 74 21 lck lck NOUN njb-44 74 22 kinase kinase NOUN njb-44 74 23 into into ADP njb-44 74 24 proximity proximity NOUN njb-44 74 25 with with ADP njb-44 74 26 tcr tcr PROPN njb-44 74 27 – – PUNCT njb-44 74 28 cd3 cd3 PROPN njb-44 74 29 itams itams PROPN njb-44 74 30 and and CCONJ njb-44 74 31 their their PRON njb-44 74 32 phosphorylation phosphorylation NOUN njb-44 74 33 . . PUNCT njb-44 75 1 further far ADV njb-44 75 2 it it PRON njb-44 75 3 has have AUX njb-44 75 4 been be AUX njb-44 75 5 proposed propose VERB njb-44 75 6 that that SCONJ njb-44 75 7 to to PART njb-44 75 8 fully fully ADV njb-44 75 9 activate activate VERB njb-44 75 10 the the DET njb-44 75 11 tcr tcr PROPN njb-44 75 12 , , PUNCT njb-44 75 13 a a DET njb-44 75 14 pmhc pmhc NOUN njb-44 75 15 ligand ligand NOUN njb-44 75 16 need need VERB njb-44 75 17 to to PART njb-44 75 18 interact interact VERB njb-44 75 19 with with ADP njb-44 75 20 a a DET njb-44 75 21 tcr tcr PROPN njb-44 75 22 – – PUNCT njb-44 75 23 cd8 cd8 PROPN njb-44 75 24 pair pair NOUN njb-44 75 25 with with ADP njb-44 75 26 a a DET njb-44 75 27 threshold threshold NOUN njb-44 75 28 time time NOUN njb-44 75 29 to to PART njb-44 75 30 induce induce VERB njb-44 75 31 stable stable ADJ njb-44 75 32 zippering zippering NOUN njb-44 75 33 between between ADP njb-44 75 34 the the DET njb-44 75 35 membrane membrane NOUN njb-44 75 36 - - PUNCT njb-44 75 37 proximal proximal ADJ njb-44 75 38 domain domain NOUN njb-44 75 39 of of ADP njb-44 75 40 cd8 cd8 PROPN njb-44 75 41 and and CCONJ njb-44 75 42 the the DET njb-44 75 43 connecting connect VERB njb-44 75 44 peptide peptide NOUN njb-44 75 45 motif motif NOUN njb-44 75 46 in in ADP njb-44 75 47 the the DET njb-44 75 48 tcrα tcrα ADJ njb-44 76 1 [ [ X njb-44 76 2 11 11 NUM njb-44 76 3 ] ] PUNCT njb-44 76 4 . . PUNCT njb-44 77 1 this this PRON njb-44 77 2 allows allow VERB njb-44 77 3 stable stable ADJ njb-44 77 4 association association NOUN njb-44 77 5 of of ADP njb-44 77 6 lck lck PROPN njb-44 77 7 with with ADP njb-44 77 8 the the DET njb-44 77 9 cd3 cd3 PROPN njb-44 77 10 complex complex NOUN njb-44 77 11 and and CCONJ njb-44 77 12 results result NOUN njb-44 77 13 in in ADP njb-44 77 14 complete complete ADJ njb-44 77 15 phosphorylation phosphorylation NOUN njb-44 77 16 of of ADP njb-44 77 17 the the DET njb-44 77 18 cd3 cd3 PROPN njb-44 77 19 itams itams PROPN njb-44 77 20 . . PUNCT njb-44 78 1 a a DET njb-44 78 2 low low ADJ njb-44 78 3 - - PUNCT njb-44 78 4 affinity affinity NOUN njb-44 78 5 pmhc pmhc NOUN njb-44 78 6 ligand ligand NOUN njb-44 78 7 that that PRON njb-44 78 8 interacts interact VERB njb-44 78 9 with with ADP njb-44 78 10 a a DET njb-44 78 11 tcr tcr PROPN njb-44 78 12 – – PUNCT njb-44 78 13 cd8 cd8 PROPN njb-44 78 14 pair pair NOUN njb-44 78 15 with with ADP njb-44 78 16 less less ADJ njb-44 78 17 than than ADP njb-44 78 18 threshold threshold NOUN njb-44 78 19 time time NOUN njb-44 78 20 induces induce VERB njb-44 78 21 incomplete incomplete ADJ njb-44 78 22 zippering zippering NOUN njb-44 78 23 and and CCONJ njb-44 78 24 therefore therefore ADV njb-44 78 25 allows allow VERB njb-44 78 26 only only ADV njb-44 78 27 transient transient ADJ njb-44 78 28 lck lck PROPN njb-44 78 29 association association PROPN njb-44 78 30 and and CCONJ njb-44 78 31 partial partial ADJ njb-44 78 32 cd3 cd3 PROPN njb-44 78 33 phosphorylation phosphorylation NOUN njb-44 78 34 . . PUNCT njb-44 79 1 however however ADV njb-44 79 2 , , PUNCT njb-44 79 3 the the DET njb-44 79 4 observations observation NOUN njb-44 79 5 that that PRON njb-44 79 6 t t NOUN njb-44 79 7 cells cell NOUN njb-44 79 8 can can AUX njb-44 79 9 develop develop VERB njb-44 79 10 and and CCONJ njb-44 79 11 function function VERB njb-44 79 12 normally normally ADV njb-44 79 13 in in ADP njb-44 79 14 the the DET njb-44 79 15 mice mouse NOUN njb-44 79 16 lacking lack VERB njb-44 79 17 both both CCONJ njb-44 79 18 cd4 cd4 X njb-44 79 19 and and CCONJ njb-44 79 20 cd8 cd8 PROPN njb-44 79 21 suggest suggest VERB njb-44 79 22 that that SCONJ njb-44 79 23 coreceptors coreceptor NOUN njb-44 79 24 are be AUX njb-44 79 25 not not PART njb-44 79 26 absolutely absolutely ADV njb-44 79 27 required require VERB njb-44 79 28 for for ADP njb-44 79 29 tcr tcr PROPN njb-44 79 30 triggering trigger VERB njb-44 79 31 and and CCONJ njb-44 79 32 t t NOUN njb-44 79 33 cell cell NOUN njb-44 79 34 activation activation NOUN njb-44 79 35 [ [ PUNCT njb-44 79 36 12 12 NUM njb-44 79 37 , , PUNCT njb-44 79 38 13 13 NUM njb-44 79 39 ] ] PUNCT njb-44 79 40 . . PUNCT njb-44 80 1 also also ADV njb-44 80 2 the the DET njb-44 80 3 fact fact NOUN njb-44 80 4 that that SCONJ njb-44 80 5 anticd3 anticd3 NOUN njb-44 80 6 antibodies antibody NOUN njb-44 80 7 and and CCONJ njb-44 80 8 their their PRON njb-44 80 9 f(ab’)2 f(ab’)2 NOUN njb-44 80 10 fragments fragment NOUN njb-44 80 11 that that PRON njb-44 80 12 do do AUX njb-44 80 13 not not PART njb-44 80 14 engage engage VERB njb-44 80 15 the the DET njb-44 80 16 co co NOUN njb-44 80 17 - - NOUN njb-44 80 18 receptors receptor NOUN njb-44 80 19 can can AUX njb-44 80 20 still still ADV njb-44 80 21 activate activate VERB njb-44 80 22 the the DET njb-44 80 23 tcr tcr PROPN njb-44 81 1 [ [ PUNCT njb-44 81 2 14 14 NUM njb-44 81 3 , , PUNCT njb-44 81 4 15 15 NUM njb-44 81 5 ] ] PUNCT njb-44 81 6 , , PUNCT njb-44 81 7 indicates indicate VERB njb-44 81 8 that that SCONJ njb-44 81 9 coreceptors coreceptor NOUN njb-44 81 10 are be AUX njb-44 81 11 not not PART njb-44 81 12 required require VERB njb-44 81 13 for for ADP njb-44 81 14 the the DET njb-44 81 15 tcr tcr PROPN njb-44 81 16 triggering trigger VERB njb-44 81 17 itself itself PRON njb-44 81 18 , , PUNCT njb-44 81 19 though though SCONJ njb-44 81 20 they they PRON njb-44 81 21 might might AUX njb-44 81 22 be be AUX njb-44 81 23 important important ADJ njb-44 81 24 for for ADP njb-44 81 25 full full ADJ njb-44 81 26 activation activation NOUN njb-44 81 27 of of ADP njb-44 81 28 a a DET njb-44 81 29 t t NOUN njb-44 81 30 cell cell NOUN njb-44 81 31 . . PUNCT njb-44 82 1 c. c. PROPN njb-44 82 2 pseudo pseudo ADJ njb-44 82 3 - - PUNCT njb-44 82 4 dimer dimer NOUN njb-44 82 5 model model NOUN njb-44 82 6 only only ADV njb-44 82 7 a a DET njb-44 82 8 few few ADJ njb-44 82 9 mhcs mhc NOUN njb-44 82 10 carry carry VERB njb-44 82 11 high high ADJ njb-44 82 12 affinity affinity NOUN njb-44 82 13 agonist agonist NOUN njb-44 82 14 peptides peptide NOUN njb-44 82 15 for for ADP njb-44 82 16 the the DET njb-44 82 17 tcrs tcrs NOUN njb-44 82 18 , , PUNCT njb-44 82 19 whereas whereas SCONJ njb-44 82 20 a a DET njb-44 82 21 great great ADJ njb-44 82 22 majority majority NOUN njb-44 82 23 of of ADP njb-44 82 24 mhcs mhcs PROPN njb-44 82 25 carry carry VERB njb-44 82 26 endogenous endogenous ADJ njb-44 82 27 selfpeptides selfpeptide NOUN njb-44 82 28 . . PUNCT njb-44 83 1 on on ADP njb-44 83 2 the the DET njb-44 83 3 basis basis NOUN njb-44 83 4 of of ADP njb-44 83 5 the the DET njb-44 83 6 crystallographic crystallographic ADJ njb-44 83 7 studies study NOUN njb-44 83 8 which which PRON njb-44 83 9 showed show VERB njb-44 83 10 that that SCONJ njb-44 83 11 the the DET njb-44 83 12 cd4 cd4 X njb-44 83 13 tail tail NOUN njb-44 83 14 associating associate VERB njb-44 83 15 with with ADP njb-44 83 16 lck lck NOUN njb-44 83 17 was be AUX njb-44 83 18 far far ADV njb-44 83 19 from from ADP njb-44 83 20 their their PRON njb-44 83 21 own own ADJ njb-44 83 22 tcr tcr PROPN njb-44 83 23 / / SYM njb-44 83 24 cd3 cd3 PROPN njb-44 83 25 complex complex PROPN njb-44 83 26 , , PUNCT njb-44 83 27 the the DET njb-44 83 28 pseudodimer pseudodimer NOUN njb-44 83 29 model model NOUN njb-44 83 30 postulates postulate VERB njb-44 83 31 that that SCONJ njb-44 83 32 two two NUM njb-44 83 33 tcrs tcr NOUN njb-44 83 34 are be AUX njb-44 83 35 brought bring VERB njb-44 83 36 together together ADV njb-44 83 37 by by ADP njb-44 83 38 binding bind VERB njb-44 83 39 low low ADJ njb-44 83 40 - - PUNCT njb-44 83 41 affinity affinity NOUN njb-44 83 42 self self NOUN njb-44 83 43 or or CCONJ njb-44 83 44 high high ADJ njb-44 83 45 - - PUNCT njb-44 83 46 affinity affinity NOUN njb-44 83 47 agonist agonist NOUN njb-44 83 48 pmhc pmhc NOUN njb-44 83 49 ligands ligand NOUN njb-44 83 50 and and CCONJ njb-44 83 51 that that SCONJ njb-44 83 52 the the DET njb-44 83 53 cd4 cd4 X njb-44 83 54 associated associate VERB njb-44 83 55 with with ADP njb-44 83 56 a a DET njb-44 83 57 tcr tcr NOUN njb-44 83 58 engaging engage VERB njb-44 83 59 the the DET njb-44 83 60 agonist agonist NOUN njb-44 83 61 pmhc pmhc NOUN njb-44 83 62 complex complex NOUN njb-44 83 63 can can AUX njb-44 83 64 assists assist NOUN njb-44 83 65 in in ADP njb-44 83 66 phosphorylation phosphorylation NOUN njb-44 83 67 of of ADP njb-44 83 68 neighboring neighboring NOUN njb-44 83 69 tcr tcr PROPN njb-44 83 70 ( ( PUNCT njb-44 83 71 engaged engage VERB njb-44 83 72 to to ADP njb-44 83 73 low low ADJ njb-44 83 74 affinity affinity NOUN njb-44 83 75 self self NOUN njb-44 83 76 peptide peptide NOUN njb-44 83 77 ) ) PUNCT njb-44 83 78 by by ADP njb-44 83 79 the the DET njb-44 83 80 associated associated ADJ njb-44 83 81 kinase kinase PROPN njb-44 83 82 lck lck NOUN njb-44 84 1 [ [ PUNCT njb-44 84 2 16 16 NUM njb-44 84 3 ] ] PUNCT njb-44 84 4 . . PUNCT njb-44 85 1 thus thus ADV njb-44 85 2 according accord VERB njb-44 85 3 to to ADP njb-44 85 4 this this DET njb-44 85 5 model model NOUN njb-44 85 6 , , PUNCT njb-44 85 7 a a DET njb-44 85 8 ‘ ' PUNCT njb-44 85 9 pseudodimer pseudodimer NOUN njb-44 85 10 ’ ' PUNCT njb-44 85 11 consists consist VERB njb-44 85 12 of of ADP njb-44 85 13 one one NUM njb-44 85 14 foreign foreign ADJ njb-44 85 15 and and CCONJ njb-44 85 16 one one NUM njb-44 85 17 self self NOUN njb-44 85 18 - - PUNCT njb-44 85 19 antigen antigen NOUN njb-44 85 20 engaged engage VERB njb-44 85 21 receptor receptor NOUN njb-44 85 22 linked link VERB njb-44 85 23 via via ADP njb-44 85 24 cd4 cd4 PROPN njb-44 85 25 molecule molecule NOUN njb-44 85 26 is be AUX njb-44 85 27 the the DET njb-44 85 28 primary primary ADJ njb-44 85 29 unit unit NOUN njb-44 85 30 of of ADP njb-44 85 31 tcr tcr PROPN njb-44 85 32 signal signal PROPN njb-44 85 33 initiation initiation NOUN njb-44 85 34 module module NOUN njb-44 85 35 . . PUNCT njb-44 86 1 2 2 X njb-44 86 2 . . X njb-44 86 3 conformational conformational ADJ njb-44 86 4 change change NOUN njb-44 86 5 model model NOUN njb-44 86 6 several several ADJ njb-44 86 7 studies study NOUN njb-44 86 8 have have AUX njb-44 86 9 proposed propose VERB njb-44 86 10 conformational conformational ADJ njb-44 86 11 nepal nepal ADJ njb-44 86 12     SPACE njb-44 86 13 journal journal NOUN njb-44 86 14     SPACE njb-44 86 15 of of ADP njb-44 86 16     SPACE njb-44 86 17 biotechnology biotechnology NOUN njb-44 86 18 . . PUNCT njb-44 86 19         SPACE njb-44 87 1 jan jan PROPN njb-44 87 2     SPACE njb-44 87 3 2012 2012 NUM njb-44 87 4 , , PUNCT njb-44 87 5     SPACE njb-44 87 6 vol vol NOUN njb-44 87 7 . . PUNCT njb-44 87 8     SPACE njb-44 88 1 2 2 NUM njb-44 88 2 , , PUNCT njb-44 88 3     SPACE njb-44 88 4 no no INTJ njb-44 88 5 . . PUNCT njb-44 88 6     SPACE njb-44 89 1 1 1 NUM njb-44 89 2 : : PUNCT njb-44 89 3     SPACE njb-44 89 4 62 62 NUM njb-44 89 5     SPACE njb-44 89 6 – – PUNCT njb-44 89 7     SPACE njb-44 89 8 71 71 NUM njb-44 89 9                                                                                                                                                                                                                                         SPACE njb-44 89 10 biotechnology biotechnology NOUN njb-44 89 11     SPACE njb-44 89 12 society society NOUN njb-44 89 13     SPACE njb-44 89 14 of of ADP njb-44 89 15     SPACE njb-44 89 16 nepal nepal NOUN njb-44 89 17     SPACE njb-44 89 18 ( ( PUNCT njb-44 89 19 bsn bsn PROPN njb-44 89 20 ) ) PUNCT njb-44 89 21 , , PUNCT njb-44 89 22     SPACE njb-44 89 23 all all DET njb-44 89 24     SPACE njb-44 89 25 rights right NOUN njb-44 89 26     SPACE njb-44 89 27 reserved reserve VERB njb-44 89 28     SPACE njb-44 89 29 67 67 NUM njb-44 89 30 change change NOUN njb-44 89 31 as as ADP njb-44 89 32 a a DET njb-44 89 33 requirement requirement NOUN njb-44 89 34 for for ADP njb-44 89 35 tcr tcr PROPN njb-44 89 36 triggering trigger VERB njb-44 89 37 [ [ PUNCT njb-44 89 38 17 17 NUM njb-44 89 39 , , PUNCT njb-44 89 40 18 18 NUM njb-44 89 41 ] ] PUNCT njb-44 89 42 . . PUNCT njb-44 90 1 however however ADV njb-44 90 2 , , PUNCT njb-44 90 3 how how SCONJ njb-44 90 4 the the DET njb-44 90 5 ligand ligand NOUN njb-44 90 6 binding bind VERB njb-44 90 7 to to ADP njb-44 90 8 tcrαβ tcrαβ NOUN njb-44 90 9 ectodomains ectodomain NOUN njb-44 90 10 leads lead VERB njb-44 90 11 to to ADP njb-44 90 12 a a DET njb-44 90 13 conformational conformational ADJ njb-44 90 14 change change NOUN njb-44 90 15 in in ADP njb-44 90 16 the the DET njb-44 90 17 cytoplasmic cytoplasmic ADJ njb-44 90 18 tails tail NOUN njb-44 90 19 of of ADP njb-44 90 20 cd3 cd3 PROPN njb-44 90 21 subunits subunit NOUN njb-44 90 22 is be AUX njb-44 90 23 not not PART njb-44 90 24 clear clear ADJ njb-44 90 25 . . PUNCT njb-44 91 1 the the DET njb-44 91 2 situation situation NOUN njb-44 91 3 is be AUX njb-44 91 4 complicated complicate VERB njb-44 91 5 by by ADP njb-44 91 6 the the DET njb-44 91 7 fact fact NOUN njb-44 91 8 that that SCONJ njb-44 91 9 the the DET njb-44 91 10 crystal crystal NOUN njb-44 91 11 structure structure NOUN njb-44 91 12 of of ADP njb-44 91 13 the the DET njb-44 91 14 fully fully ADV njb-44 91 15 assembled assemble VERB njb-44 91 16 tcr tcr PROPN njb-44 91 17 - - PUNCT njb-44 91 18 cd3 cd3 PROPN njb-44 91 19 complex complex NOUN njb-44 91 20 is be AUX njb-44 91 21 not not PART njb-44 91 22 known know VERB njb-44 91 23 , , PUNCT njb-44 91 24 although although SCONJ njb-44 91 25 individual individual ADJ njb-44 91 26 subunits subunit NOUN njb-44 91 27 have have AUX njb-44 91 28 been be AUX njb-44 91 29 crystallized crystallize VERB njb-44 91 30 partially partially ADV njb-44 91 31 [ [ X njb-44 91 32 1922 1922 NUM njb-44 91 33 ] ] PUNCT njb-44 91 34 . . PUNCT njb-44 92 1 some some PRON njb-44 92 2 of of ADP njb-44 92 3 the the DET njb-44 92 4 important important ADJ njb-44 92 5 models model NOUN njb-44 92 6 for for ADP njb-44 92 7 the the DET njb-44 92 8 mechanism mechanism NOUN njb-44 92 9 of of ADP njb-44 92 10 conformational conformational ADJ njb-44 92 11 change change NOUN njb-44 92 12 in in ADP njb-44 92 13 tcrcd3 tcrcd3 PROPN njb-44 92 14 are be AUX njb-44 92 15 discussed discuss VERB njb-44 92 16 below below ADP njb-44 92 17 . . PUNCT njb-44 93 1 a. a. NOUN njb-44 93 2 membrane membrane NOUN njb-44 93 3 binding bind VERB njb-44 93 4 model model NOUN njb-44 93 5 according accord VERB njb-44 93 6 to to ADP njb-44 93 7 this this DET njb-44 93 8 model model NOUN njb-44 93 9 , , PUNCT njb-44 93 10 cytoplasmic cytoplasmic ADJ njb-44 93 11 tails tail NOUN njb-44 93 12 of of ADP njb-44 93 13 cd3ε cd3ε PROPN njb-44 94 1 [ [ PUNCT njb-44 94 2 23 23 NUM njb-44 94 3 , , PUNCT njb-44 94 4 24 24 NUM njb-44 94 5 ] ] PUNCT njb-44 94 6 and and CCONJ njb-44 94 7 cd3ζ cd3ζ NOUN njb-44 94 8 [ [ PUNCT njb-44 94 9 25 25 NUM njb-44 94 10 ] ] PUNCT njb-44 94 11 associate associate NOUN njb-44 94 12 with with ADP njb-44 94 13 the the DET njb-44 94 14 lipids lipid NOUN njb-44 94 15 present present ADJ njb-44 94 16 in in ADP njb-44 94 17 the the DET njb-44 94 18 plasma plasma NOUN njb-44 94 19 membrane membrane NOUN njb-44 94 20 of of ADP njb-44 94 21 a a DET njb-44 94 22 t t NOUN njb-44 94 23 cell cell NOUN njb-44 94 24 . . PUNCT njb-44 95 1 thereby thereby ADV njb-44 95 2 , , PUNCT njb-44 95 3 the the DET njb-44 95 4 itams itams PROPN njb-44 95 5 are be AUX njb-44 95 6 buried bury VERB njb-44 95 7 in in ADP njb-44 95 8 the the DET njb-44 95 9 plasma plasma NOUN njb-44 95 10 membrane membrane NOUN njb-44 95 11 , , PUNCT njb-44 95 12 making make VERB njb-44 95 13 them they PRON njb-44 95 14 inaccessible inaccessible ADJ njb-44 95 15 for for ADP njb-44 95 16 phosphorylation phosphorylation NOUN njb-44 95 17 by by ADP njb-44 95 18 the the DET njb-44 95 19 kinases kinase NOUN njb-44 95 20 . . PUNCT njb-44 96 1 ligand ligand NOUN njb-44 96 2 binding binding NOUN njb-44 96 3 leads lead VERB njb-44 96 4 to to ADP njb-44 96 5 release release NOUN njb-44 96 6 of of ADP njb-44 96 7 these these DET njb-44 96 8 cd3 cd3 PROPN njb-44 96 9 chains chain NOUN njb-44 96 10 from from ADP njb-44 96 11 the the DET njb-44 96 12 plasma plasma NOUN njb-44 96 13 membrane membrane NOUN njb-44 96 14 , , PUNCT njb-44 96 15 making make VERB njb-44 96 16 them they PRON njb-44 96 17 accessible accessible ADJ njb-44 96 18 to to PART njb-44 96 19 kinase kinase VERB njb-44 96 20 and and CCONJ njb-44 96 21 hence hence ADV njb-44 96 22 the the DET njb-44 96 23 phosphorylation phosphorylation NOUN njb-44 96 24 . . PUNCT njb-44 97 1 b. b. PROPN njb-44 97 2 kinetic kinetic PROPN njb-44 97 3 deformation deformation NOUN njb-44 97 4 model model NOUN njb-44 97 5 several several ADJ njb-44 97 6 line line NOUN njb-44 97 7 of of ADP njb-44 97 8 evidence evidence NOUN njb-44 97 9 have have AUX njb-44 97 10 proposed propose VERB njb-44 97 11 that that SCONJ njb-44 97 12 the the DET njb-44 97 13 mechanical mechanical ADJ njb-44 97 14 effects effect NOUN njb-44 97 15 ( ( PUNCT njb-44 97 16 such such ADJ njb-44 97 17 as as ADP njb-44 97 18 pulling pull VERB njb-44 97 19 or or CCONJ njb-44 97 20 shearing shearing NOUN njb-44 97 21 ) ) PUNCT njb-44 97 22 of of ADP njb-44 97 23 pmhc pmhc NOUN njb-44 97 24 binding bind VERB njb-44 97 25 to to ADP njb-44 97 26 the the DET njb-44 97 27 tcr tcr PROPN njb-44 97 28 leads lead VERB njb-44 97 29 to to ADP njb-44 97 30 a a DET njb-44 97 31 piston piston NOUN njb-44 97 32 - - PUNCT njb-44 97 33 like like ADJ njb-44 97 34 displacement displacement NOUN njb-44 97 35 of of ADP njb-44 97 36 the the DET njb-44 97 37 tcr tcr PROPN njb-44 97 38 – – PUNCT njb-44 97 39 cd3 cd3 PROPN njb-44 97 40 complex complex NOUN njb-44 98 1 [ [ PUNCT njb-44 98 2 26 26 NUM njb-44 98 3 , , PUNCT njb-44 98 4 27 27 NUM njb-44 98 5 ] ] PUNCT njb-44 98 6 . . PUNCT njb-44 99 1 this this PRON njb-44 99 2 induces induce VERB njb-44 99 3 a a DET njb-44 99 4 change change NOUN njb-44 99 5 in in ADP njb-44 99 6 the the DET njb-44 99 7 conformation conformation NOUN njb-44 99 8 of of ADP njb-44 99 9 the the DET njb-44 99 10 cd3 cd3 PROPN njb-44 99 11 cytoplasmic cytoplasmic ADJ njb-44 99 12 domains domain NOUN njb-44 99 13 , , PUNCT njb-44 99 14 allowing allow VERB njb-44 99 15 itam itam NOUN njb-44 99 16 phosphorylation phosphorylation NOUN njb-44 99 17 . . PUNCT njb-44 100 1 c. c. PROPN njb-44 100 2 permissive permissive ADJ njb-44 100 3 geometry geometry NOUN njb-44 100 4 model model NOUN njb-44 100 5 based base VERB njb-44 100 6 on on ADP njb-44 100 7 the the DET njb-44 100 8 experimental experimental ADJ njb-44 100 9 evidence evidence NOUN njb-44 100 10 for for ADP njb-44 100 11 the the DET njb-44 100 12 existence existence NOUN njb-44 100 13 of of ADP njb-44 100 14 tcr tcr PROPN njb-44 100 15 - - PUNCT njb-44 100 16 cd3s cd3s NOUN njb-44 100 17 in in ADP njb-44 100 18 a a DET njb-44 100 19 pre pre ADJ njb-44 100 20 - - ADJ njb-44 100 21 clustered cluster VERB njb-44 100 22 form form NOUN njb-44 100 23 [ [ X njb-44 100 24 7 7 NUM njb-44 100 25 ] ] PUNCT njb-44 100 26 and and CCONJ njb-44 100 27 the the DET njb-44 100 28 fact fact NOUN njb-44 100 29 that that SCONJ njb-44 100 30 pmhc pmhc NOUN njb-44 100 31 monomers monomer NOUN njb-44 100 32 in in ADP njb-44 100 33 solution solution NOUN njb-44 100 34 fail fail VERB njb-44 100 35 to to PART njb-44 100 36 trigger trigger VERB njb-44 100 37 tcr[28 tcr[28 PROPN njb-44 100 38 , , PUNCT njb-44 100 39 29 29 NUM njb-44 100 40 ] ] PUNCT njb-44 100 41 while while SCONJ njb-44 100 42 pmhc pmhc NOUN njb-44 100 43 dimer dimer NOUN njb-44 100 44 or or CCONJ njb-44 100 45 higher high ADJ njb-44 100 46 oligomer oligomer NOUN njb-44 100 47 can can AUX njb-44 100 48 induce induce VERB njb-44 100 49 tcr tcr PROPN njb-44 100 50 triggering trigger VERB njb-44 100 51 , , PUNCT njb-44 100 52 the the DET njb-44 100 53 permissive permissive ADJ njb-44 100 54 geometry geometry NOUN njb-44 100 55 model model NOUN njb-44 100 56 was be AUX njb-44 100 57 proposed[30 proposed[30 X njb-44 100 58 ] ] PUNCT njb-44 100 59 . . PUNCT njb-44 101 1 according accord VERB njb-44 101 2 to to ADP njb-44 101 3 this this DET njb-44 101 4 model model NOUN njb-44 101 5 , , PUNCT njb-44 101 6 before before ADP njb-44 101 7 ligand ligand NOUN njb-44 101 8 binding binding NOUN njb-44 101 9 , , PUNCT njb-44 101 10 the the DET njb-44 101 11 mono mono PROPN njb-44 101 12 and and CCONJ njb-44 101 13 multivalent multivalent ADJ njb-44 101 14 tcr tcr PROPN njb-44 101 15 - - PUNCT njb-44 101 16 cd3s cd3s NOUN njb-44 101 17 exist exist VERB njb-44 101 18 in in ADP njb-44 101 19 an an DET njb-44 101 20 autoinhibited autoinhibited ADJ njb-44 101 21 state state NOUN njb-44 101 22 where where SCONJ njb-44 101 23 itams itams PROPN njb-44 101 24 are be AUX njb-44 101 25 inaccessible inaccessible ADJ njb-44 101 26 for for ADP njb-44 101 27 phosphorylation phosphorylation NOUN njb-44 101 28 by by ADP njb-44 101 29 the the DET njb-44 101 30 kinase kinase NOUN njb-44 101 31 . . PUNCT njb-44 102 1 simultaneous simultaneous ADJ njb-44 102 2 dimeric dimeric NOUN njb-44 102 3 ( ( PUNCT njb-44 102 4 or or CCONJ njb-44 102 5 higher high ADJ njb-44 102 6 order order NOUN njb-44 102 7 ) ) PUNCT njb-44 102 8 ligand ligand NOUN njb-44 102 9 binding bind VERB njb-44 102 10 to to ADP njb-44 102 11 the the DET njb-44 102 12 two two NUM njb-44 102 13 tcr tcr PROPN njb-44 102 14 - - PUNCT njb-44 102 15 cd3 cd3 PROPN njb-44 102 16 complexes complex NOUN njb-44 102 17 leads lead VERB njb-44 102 18 to to ADP njb-44 102 19 a a DET njb-44 102 20 scissor scissor NOUN njb-44 102 21 - - PUNCT njb-44 102 22 like like ADJ njb-44 102 23 movement movement NOUN njb-44 102 24 in in ADP njb-44 102 25 the the DET njb-44 102 26 two two NUM njb-44 102 27 tcrcd3 tcrcd3 PROPN njb-44 102 28 complexes complex NOUN njb-44 102 29 leading lead VERB njb-44 102 30 to to ADP njb-44 102 31 exposure exposure NOUN njb-44 102 32 of of ADP njb-44 102 33 their their PRON njb-44 102 34 cytoplasmic cytoplasmic ADJ njb-44 102 35 tails tail NOUN njb-44 102 36 , , PUNCT njb-44 102 37 thus thus ADV njb-44 102 38 making make VERB njb-44 102 39 the the DET njb-44 102 40 itams itams PROPN njb-44 102 41 accessible accessible ADJ njb-44 102 42 for for ADP njb-44 102 43 phosphorylation phosphorylation NOUN njb-44 102 44 . . PUNCT njb-44 103 1 3 3 X njb-44 103 2 . . X njb-44 103 3 segregation segregation NOUN njb-44 103 4 model model NOUN njb-44 103 5 in in ADP njb-44 103 6 a a DET njb-44 103 7 resting rest VERB njb-44 103 8 t t NOUN njb-44 103 9 cell cell NOUN njb-44 103 10 , , PUNCT njb-44 103 11 phosphorylation phosphorylation NOUN njb-44 103 12 of of ADP njb-44 103 13 the the DET njb-44 103 14 tcr tcr PROPN njb-44 103 15 - - PUNCT njb-44 103 16 cd3 cd3 PROPN njb-44 103 17 is be AUX njb-44 103 18 kept keep VERB njb-44 103 19 in in ADP njb-44 103 20 check check NOUN njb-44 103 21 by by ADP njb-44 103 22 the the DET njb-44 103 23 active active ADJ njb-44 103 24 phosphotases phosphotase NOUN njb-44 103 25 . . PUNCT njb-44 104 1 this this PRON njb-44 104 2 is be AUX njb-44 104 3 supported support VERB njb-44 104 4 by by ADP njb-44 104 5 the the DET njb-44 104 6 fact fact NOUN njb-44 104 7 that that SCONJ njb-44 104 8 pervanadate pervanadate NOUN njb-44 104 9 , , PUNCT njb-44 104 10 a a DET njb-44 104 11 phosphatase phosphatase NOUN njb-44 104 12 inhibitor inhibitor NOUN njb-44 104 13 , , PUNCT njb-44 104 14 nepal nepal ADJ njb-44 104 15     SPACE njb-44 104 16 journal journal NOUN njb-44 104 17     SPACE njb-44 104 18 of of ADP njb-44 104 19     SPACE njb-44 104 20 biotechnology biotechnology NOUN njb-44 104 21 . . PUNCT njb-44 104 22         SPACE njb-44 105 1 jan jan PROPN njb-44 105 2     SPACE njb-44 105 3 2012 2012 NUM njb-44 105 4 , , PUNCT njb-44 105 5     SPACE njb-44 105 6 vol vol NOUN njb-44 105 7 . . PUNCT njb-44 105 8     SPACE njb-44 106 1 2 2 NUM njb-44 106 2 , , PUNCT njb-44 106 3     SPACE njb-44 106 4 no no INTJ njb-44 106 5 . . PUNCT njb-44 106 6     SPACE njb-44 107 1 1 1 NUM njb-44 107 2 : : PUNCT njb-44 107 3     SPACE njb-44 107 4 62 62 NUM njb-44 107 5     SPACE njb-44 107 6 – – PUNCT njb-44 107 7     SPACE njb-44 107 8 71 71 NUM njb-44 107 9                                                                                                                                                                                                                                         SPACE njb-44 107 10 biotechnology biotechnology NOUN njb-44 107 11     SPACE njb-44 107 12 society society NOUN njb-44 107 13     SPACE njb-44 107 14 of of ADP njb-44 107 15     SPACE njb-44 107 16 nepal nepal NOUN njb-44 107 17     SPACE njb-44 107 18 ( ( PUNCT njb-44 107 19 bsn bsn PROPN njb-44 107 20 ) ) PUNCT njb-44 107 21 , , PUNCT njb-44 107 22     SPACE njb-44 107 23 all all DET njb-44 107 24     SPACE njb-44 107 25 rights right NOUN njb-44 107 26     SPACE njb-44 107 27 reserved reserve VERB njb-44 107 28     SPACE njb-44 107 29 68 68 NUM njb-44 107 30 treatment treatment NOUN njb-44 107 31 leads lead VERB njb-44 107 32 to to ADP njb-44 107 33 strong strong ADJ njb-44 107 34 phosphorylation phosphorylation NOUN njb-44 107 35 of of ADP njb-44 107 36 the the DET njb-44 107 37 tcr tcr PROPN njb-44 107 38 - - PUNCT njb-44 107 39 cd3 cd3 PROPN njb-44 107 40 itams itams PROPN njb-44 107 41 and and CCONJ njb-44 107 42 also also ADV njb-44 107 43 initiates initiate VERB njb-44 107 44 the the DET njb-44 107 45 downstream downstream NOUN njb-44 107 46 signaling signal VERB njb-44 107 47 [ [ PUNCT njb-44 107 48 31 31 NUM njb-44 107 49 ] ] PUNCT njb-44 107 50 . . PUNCT njb-44 108 1 thus thus ADV njb-44 108 2 any any DET njb-44 108 3 process process NOUN njb-44 108 4 that that PRON njb-44 108 5 favors favor VERB njb-44 108 6 the the DET njb-44 108 7 kinase kinase ADJ njb-44 108 8 - - PUNCT njb-44 108 9 phosphtase phosphtase NOUN njb-44 108 10 balance balance NOUN njb-44 108 11 towards towards ADP njb-44 108 12 kinase kinase NOUN njb-44 108 13 , , PUNCT njb-44 108 14 can can AUX njb-44 108 15 lead lead VERB njb-44 108 16 to to ADP njb-44 108 17 tcr tcr PROPN njb-44 108 18 - - PUNCT njb-44 108 19 cd3 cd3 PROPN njb-44 108 20 phosphorylation phosphorylation NOUN njb-44 108 21 and and CCONJ njb-44 108 22 the the DET njb-44 108 23 signaling signaling NOUN njb-44 108 24 . . PUNCT njb-44 109 1 redistribution redistribution NOUN njb-44 109 2 of of ADP njb-44 109 3 the the DET njb-44 109 4 tcr tcr PROPN njb-44 109 5 - - PUNCT njb-44 109 6 cd3 cd3 PROPN njb-44 109 7 , , PUNCT njb-44 109 8 kinases kinase NOUN njb-44 109 9 and and CCONJ njb-44 109 10 phosphatases phosphatase NOUN njb-44 109 11 in in ADP njb-44 109 12 which which PRON njb-44 109 13 phosphatase phosphatase NOUN njb-44 109 14 is be AUX njb-44 109 15 segregated segregate VERB njb-44 109 16 from from ADP njb-44 109 17 the the DET njb-44 109 18 tcr tcr PROPN njb-44 109 19 can can AUX njb-44 109 20 interfere interfere VERB njb-44 109 21 with with ADP njb-44 109 22 the the DET njb-44 109 23 dephosphorylation dephosphorylation NOUN njb-44 109 24 . . PUNCT njb-44 110 1 there there PRON njb-44 110 2 are be VERB njb-44 110 3 two two NUM njb-44 110 4 mechanisms mechanism NOUN njb-44 110 5 proposed propose VERB njb-44 110 6 for for ADP njb-44 110 7 such such ADJ njb-44 110 8 ligand ligand NOUN njb-44 110 9 dependent dependent ADJ njb-44 110 10 re re NOUN njb-44 110 11 - - NOUN njb-44 110 12 distribution distribution NOUN njb-44 110 13 , , PUNCT njb-44 110 14 which which PRON njb-44 110 15 are be AUX njb-44 110 16 discussed discuss VERB njb-44 110 17 below below ADP njb-44 110 18 . . PUNCT njb-44 111 1 a. a. NOUN njb-44 111 2 kinetic kinetic PROPN njb-44 111 3 segregation segregation PROPN njb-44 111 4 kinetic kinetic PROPN njb-44 111 5 segregation segregation NOUN njb-44 111 6 model model NOUN njb-44 111 7 was be AUX njb-44 111 8 proposed propose VERB njb-44 111 9 based base VERB njb-44 111 10 on on ADP njb-44 111 11 the the DET njb-44 111 12 topological topological ADJ njb-44 111 13 view view NOUN njb-44 111 14 of of ADP njb-44 111 15 the the DET njb-44 111 16 cell cell NOUN njb-44 111 17 surface surface NOUN njb-44 111 18 molecules molecule NOUN njb-44 111 19 at at ADP njb-44 111 20 the the DET njb-44 111 21 t t PROPN njb-44 111 22 cell cell NOUN njb-44 111 23 – – PUNCT njb-44 111 24 apc apc NOUN njb-44 111 25 interface interface NOUN njb-44 111 26 [ [ PUNCT njb-44 111 27 32 32 NUM njb-44 111 28 , , PUNCT njb-44 111 29 33 33 NUM njb-44 111 30 ] ] PUNCT njb-44 111 31 . . PUNCT njb-44 112 1 the the DET njb-44 112 2 tight tight ADJ njb-44 112 3 intercellular intercellular ADJ njb-44 112 4 contact contact NOUN njb-44 112 5 causes cause VERB njb-44 112 6 the the DET njb-44 112 7 segregation segregation NOUN njb-44 112 8 of of ADP njb-44 112 9 the the DET njb-44 112 10 molecules molecule NOUN njb-44 112 11 by by ADP njb-44 112 12 sizes size NOUN njb-44 112 13 of of ADP njb-44 112 14 their their PRON njb-44 112 15 ectodomain ectodomain NOUN njb-44 112 16 resulting result VERB njb-44 112 17 in in ADP njb-44 112 18 physical physical ADJ njb-44 112 19 separation separation NOUN njb-44 112 20 of of ADP njb-44 112 21 tcr tcr PROPN njb-44 112 22 from from ADP njb-44 112 23 the the DET njb-44 112 24 large large ADJ njb-44 112 25 inhibitory inhibitory ADJ njb-44 112 26 tyrosine tyrosine NOUN njb-44 112 27 phosphatase phosphatase NOUN njb-44 112 28 cd45 cd45 PROPN njb-44 112 29 , , PUNCT njb-44 112 30 leading lead VERB njb-44 112 31 to to ADP njb-44 112 32 stable stable ADJ njb-44 112 33 phosphorylation phosphorylation NOUN njb-44 112 34 of of ADP njb-44 112 35 tcr tcr PROPN njb-44 112 36 – – PUNCT njb-44 112 37 cd3 cd3 PROPN njb-44 112 38 itams itams PROPN njb-44 112 39 by by ADP njb-44 112 40 lck lck PROPN njb-44 112 41 . . PROPN njb-44 112 42 though though SCONJ njb-44 112 43 sounding sound VERB njb-44 112 44 good good ADJ njb-44 112 45 in in ADP njb-44 112 46 the the DET njb-44 112 47 context context NOUN njb-44 112 48 of of ADP njb-44 112 49 a a DET njb-44 112 50 tcell tcell NOUN njb-44 112 51 – – PUNCT njb-44 112 52 apc apc ADJ njb-44 112 53 contact contact NOUN njb-44 112 54 , , PUNCT njb-44 112 55 the the DET njb-44 112 56 model model NOUN njb-44 112 57 fails fail VERB njb-44 112 58 to to PART njb-44 112 59 explain explain VERB njb-44 112 60 the the DET njb-44 112 61 activation activation NOUN njb-44 112 62 of of ADP njb-44 112 63 t t NOUN njb-44 112 64 cells cell NOUN njb-44 112 65 by by ADP njb-44 112 66 soluble soluble ADJ njb-44 112 67 antitcrαβ antitcrαβ NOUN njb-44 112 68 and and CCONJ njb-44 112 69 anti anti ADJ njb-44 112 70 - - ADJ njb-44 112 71 cd3 cd3 ADJ njb-44 112 72 antibodies antibody NOUN njb-44 112 73 and and CCONJ njb-44 112 74 the the DET njb-44 112 75 pmhc pmhc NOUN njb-44 112 76 tetramer tetramer PROPN njb-44 112 77 [ [ PUNCT njb-44 112 78 14 14 NUM njb-44 112 79 , , PUNCT njb-44 112 80 34 34 NUM njb-44 112 81 ] ] PUNCT njb-44 112 82 . . PUNCT njb-44 113 1 b. b. PROPN njb-44 113 2 lipid lipid PROPN njb-44 113 3 raft raft PROPN njb-44 113 4 mediated mediate VERB njb-44 113 5 segregation segregation NOUN njb-44 113 6 model model NOUN njb-44 113 7 lipid lipid NOUN njb-44 113 8 rafts raft NOUN njb-44 113 9 are be AUX njb-44 113 10 the the DET njb-44 113 11 detergent detergent NOUN njb-44 113 12 ( ( PUNCT njb-44 113 13 such such ADJ njb-44 113 14 as as ADP njb-44 113 15 triton triton PROPN njb-44 113 16 x100 x100 PROPN njb-44 113 17 , , PUNCT njb-44 113 18 brij brij PROPN njb-44 113 19 - - PUNCT njb-44 113 20 series series NOUN njb-44 113 21 , , PUNCT njb-44 113 22 np-40 np-40 ADJ njb-44 113 23 or or CCONJ njb-44 113 24 chaps)-resistant chaps)-resistant ADJ njb-44 113 25 membrane membrane NOUN njb-44 113 26 microdomains microdomain NOUN njb-44 113 27 which which PRON njb-44 113 28 are be AUX njb-44 113 29 enriched enrich VERB njb-44 113 30 in in ADP njb-44 113 31 glycosphingolipids glycosphingolipid NOUN njb-44 113 32 , , PUNCT njb-44 113 33 cholesterol cholesterol NOUN njb-44 113 34 and and CCONJ njb-44 113 35 lipidmodified lipidmodifie VERB njb-44 113 36 proteins protein NOUN njb-44 113 37 such such ADJ njb-44 113 38 as as ADP njb-44 113 39 the the DET njb-44 113 40 gpi gpi NOUN njb-44 113 41 - - PUNCT njb-44 113 42 anchored anchor VERB njb-44 113 43 proteins protein NOUN njb-44 113 44 . . PUNCT njb-44 114 1 also also ADV njb-44 114 2 these these DET njb-44 114 3 microdomains microdomain NOUN njb-44 114 4 are be AUX njb-44 114 5 enriched enrich VERB njb-44 114 6 in in ADP njb-44 114 7 double double ADV njb-44 114 8 - - PUNCT njb-44 114 9 acylated acylate VERB njb-44 114 10 ( ( PUNCT njb-44 114 11 myristoylated myristoylate VERB njb-44 114 12 , , PUNCT njb-44 114 13 palmitoylated palmitoylate VERB njb-44 114 14 ) ) PUNCT njb-44 114 15 src src NOUN njb-44 114 16 - - PUNCT njb-44 114 17 family family NOUN njb-44 114 18 kinases kinase NOUN njb-44 114 19 and and CCONJ njb-44 114 20 the the DET njb-44 114 21 important important ADJ njb-44 114 22 signaling signal VERB njb-44 114 23 molecules molecule NOUN njb-44 114 24 such such ADJ njb-44 114 25 as as ADP njb-44 114 26 the the DET njb-44 114 27 coreceptors coreceptor NOUN njb-44 114 28 cd4 cd4 X njb-44 114 29 and and CCONJ njb-44 114 30 cd8 cd8 PROPN njb-44 114 31 and and CCONJ njb-44 114 32 the the DET njb-44 114 33 adaptor adaptor NOUN njb-44 114 34 protein protein PROPN njb-44 114 35 lat lat PROPN njb-44 114 36 . . PUNCT njb-44 115 1 lipid lipid PROPN njb-44 115 2 raft raft PROPN njb-44 115 3 mediated mediate VERB njb-44 115 4 segregation segregation NOUN njb-44 115 5 model model NOUN njb-44 115 6 postulates postulate VERB njb-44 115 7 that that SCONJ njb-44 115 8 pmhc pmhc NOUN njb-44 115 9 engagement engagement NOUN njb-44 115 10 results result NOUN njb-44 115 11 in in ADP njb-44 115 12 partitioning partitioning NOUN njb-44 115 13 of of ADP njb-44 115 14 the the DET njb-44 115 15 tcr tcr PROPN njb-44 115 16 – – PUNCT njb-44 115 17 cd3 cd3 PROPN njb-44 115 18 complex complex NOUN njb-44 115 19 into into ADP njb-44 115 20 lipid lipid ADJ njb-44 115 21 rafts raft NOUN njb-44 115 22 enriched enrich VERB njb-44 115 23 in in ADP njb-44 115 24 lck lck NOUN njb-44 115 25 and and CCONJ njb-44 115 26 deficient deficient ADJ njb-44 115 27 in in ADP njb-44 115 28 cd45 cd45 PROPN njb-44 116 1 [ [ PUNCT njb-44 116 2 35 35 NUM njb-44 116 3 , , PUNCT njb-44 116 4 36 36 NUM njb-44 116 5 ] ] PUNCT njb-44 116 6 . . PUNCT njb-44 117 1 partial partial ADJ njb-44 117 2 support support NOUN njb-44 117 3 for for ADP njb-44 117 4 this this DET njb-44 117 5 model model NOUN njb-44 117 6 comes come VERB njb-44 117 7 from from ADP njb-44 117 8 the the DET njb-44 117 9 observations observation NOUN njb-44 117 10 that that SCONJ njb-44 117 11 palmitoylation palmitoylation NOUN njb-44 117 12 - - PUNCT njb-44 117 13 deficient deficient ADJ njb-44 117 14 ( ( PUNCT njb-44 117 15 and and CCONJ njb-44 117 16 raft raft NOUN njb-44 117 17 excluded exclude VERB njb-44 117 18 ) ) PUNCT njb-44 117 19 mutants mutant NOUN njb-44 117 20 of of ADP njb-44 117 21 lck lck NOUN njb-44 117 22 and and CCONJ njb-44 117 23 lat lat NOUN njb-44 117 24 are be AUX njb-44 117 25 functionally functionally ADV njb-44 117 26 defective defective ADJ njb-44 117 27 . . PUNCT njb-44 118 1 in in ADP njb-44 118 2 addition addition NOUN njb-44 118 3 , , PUNCT njb-44 118 4 artificial artificial ADJ njb-44 118 5 targeting targeting NOUN njb-44 118 6 of of ADP njb-44 118 7 other other ADJ njb-44 118 8 cytoplasmic cytoplasmic ADJ njb-44 118 9 molecules molecule NOUN njb-44 118 10 , , PUNCT njb-44 118 11 such such ADJ njb-44 118 12 as as ADP njb-44 118 13 shp-1 shp-1 NOUN njb-44 118 14 [ [ X njb-44 118 15 37 37 NUM njb-44 118 16 ] ] PUNCT njb-44 118 17 , , PUNCT njb-44 118 18 cd45 cd45 PROPN njb-44 119 1 [ [ X njb-44 119 2 38 38 NUM njb-44 119 3 ] ] PUNCT njb-44 119 4 or or CCONJ njb-44 119 5 plcγ plcγ ADJ njb-44 120 1 [ [ X njb-44 120 2 39 39 NUM njb-44 120 3 ] ] PUNCT njb-44 120 4 , , PUNCT njb-44 120 5 to to PART njb-44 120 6 membrane membrane NOUN njb-44 120 7 rafts raft NOUN njb-44 120 8 has have AUX njb-44 120 9 marked mark VERB njb-44 120 10 functional functional ADJ njb-44 120 11 effects effect NOUN njb-44 120 12 on on ADP njb-44 120 13 tcrinduced tcrinduced ADJ njb-44 120 14 signaling signaling NOUN njb-44 120 15 . . PUNCT njb-44 121 1 a a DET njb-44 121 2 connecting connect VERB njb-44 121 3 peptide peptide NOUN njb-44 121 4 in in ADP njb-44 121 5 the the DET njb-44 121 6 tcrα tcrα ADJ njb-44 121 7 chain chain NOUN njb-44 121 8 and and CCONJ njb-44 121 9 the the DET njb-44 121 10 cd3δ cd3δ PROPN njb-44 121 11 chain chain NOUN njb-44 121 12 were be AUX njb-44 121 13 identified identify VERB njb-44 121 14 as as ADP njb-44 121 15 the the DET njb-44 121 16 critical critical ADJ njb-44 121 17 sites site NOUN njb-44 121 18 essential essential ADJ njb-44 121 19 for for ADP njb-44 121 20 effective effective ADJ njb-44 121 21 raft raft PROPN njb-44 121 22 association association NOUN njb-44 121 23 . . PUNCT njb-44 122 1 mutations mutation NOUN njb-44 122 2 in in ADP njb-44 122 3 these these DET njb-44 122 4 components component NOUN njb-44 122 5 interfere interfere VERB njb-44 122 6 with with ADP njb-44 122 7 tcr tcr PROPN njb-44 122 8 signaling signal VERB njb-44 122 9 [ [ PUNCT njb-44 122 10 40 40 NUM njb-44 122 11 ] ] PUNCT njb-44 122 12 . . PUNCT njb-44 123 1 the the DET njb-44 123 2 mechanism mechanism NOUN njb-44 123 3 of of ADP njb-44 123 4 directing direct VERB njb-44 123 5 association association NOUN njb-44 123 6 of of ADP njb-44 123 7 the the DET njb-44 123 8 engaged engage VERB njb-44 123 9 tcr tcr PROPN njb-44 123 10 complex complex PROPN njb-44 123 11 with with ADP njb-44 123 12 lipid lipid ADJ njb-44 123 13 rafts raft NOUN njb-44 123 14 is be AUX njb-44 123 15 not not PART njb-44 123 16 clear clear ADJ njb-44 123 17 but but CCONJ njb-44 123 18 might might AUX njb-44 123 19 be be AUX njb-44 123 20 based base VERB njb-44 123 21 on on ADP njb-44 123 22 co co NOUN njb-44 123 23 - - NOUN njb-44 123 24 engagement engagement NOUN njb-44 123 25 of of ADP njb-44 123 26 the the DET njb-44 123 27 raft raft NOUN njb-44 123 28 resident resident NOUN njb-44 123 29 cd4 cd4 PROPN njb-44 123 30 / / SYM njb-44 123 31 cd8 cd8 PROPN njb-44 123 32 coreceptors coreceptors PROPN njb-44 123 33 . . PUNCT njb-44 124 1 nepal nepal ADJ njb-44 124 2     SPACE njb-44 124 3 journal journal NOUN njb-44 124 4     SPACE njb-44 124 5 of of ADP njb-44 124 6     SPACE njb-44 124 7 biotechnology biotechnology NOUN njb-44 124 8 . . PUNCT njb-44 124 9         SPACE njb-44 125 1 jan jan PROPN njb-44 125 2     SPACE njb-44 125 3 2012 2012 NUM njb-44 125 4 , , PUNCT njb-44 125 5     SPACE njb-44 125 6 vol vol NOUN njb-44 125 7 . . PUNCT njb-44 125 8     SPACE njb-44 126 1 2 2 NUM njb-44 126 2 , , PUNCT njb-44 126 3     SPACE njb-44 126 4 no no INTJ njb-44 126 5 . . PUNCT njb-44 126 6     SPACE njb-44 127 1 1 1 NUM njb-44 127 2 : : PUNCT njb-44 127 3     SPACE njb-44 127 4 62 62 NUM njb-44 127 5     SPACE njb-44 127 6 – – PUNCT njb-44 127 7     SPACE njb-44 127 8 71 71 NUM njb-44 127 9                                                                                                                                                                                                                                         SPACE njb-44 127 10 biotechnology biotechnology NOUN njb-44 127 11     SPACE njb-44 127 12 society society NOUN njb-44 127 13     SPACE njb-44 127 14 of of ADP njb-44 127 15     SPACE njb-44 127 16 nepal nepal NOUN njb-44 127 17     SPACE njb-44 127 18 ( ( PUNCT njb-44 127 19 bsn bsn PROPN njb-44 127 20 ) ) PUNCT njb-44 127 21 , , PUNCT njb-44 127 22     SPACE njb-44 127 23 all all DET njb-44 127 24     SPACE njb-44 127 25 rights right NOUN njb-44 127 26     SPACE njb-44 127 27 reserved reserve VERB njb-44 127 28     SPACE njb-44 127 29 69 69 NUM njb-44 127 30 conclusion conclusion NOUN njb-44 127 31 analysis analysis NOUN njb-44 127 32 of of ADP njb-44 127 33 various various ADJ njb-44 127 34 proposed propose VERB njb-44 127 35 mechanisms mechanism NOUN njb-44 127 36 reveals reveal VERB njb-44 127 37 that that SCONJ njb-44 127 38 probably probably ADV njb-44 127 39 a a DET njb-44 127 40 combination combination NOUN njb-44 127 41 of of ADP njb-44 127 42 these these DET njb-44 127 43 mechanisms mechanism NOUN njb-44 127 44 is be AUX njb-44 127 45 responsible responsible ADJ njb-44 127 46 for for ADP njb-44 127 47 tcr tcr PROPN njb-44 127 48 triggering trigger VERB njb-44 127 49 . . PUNCT njb-44 128 1 existence existence NOUN njb-44 128 2 of of ADP njb-44 128 3 pre pre ADJ njb-44 128 4 - - ADJ njb-44 128 5 clustered cluster VERB njb-44 128 6 tcr tcr PROPN njb-44 128 7 molecules molecule NOUN njb-44 128 8 rules rule VERB njb-44 128 9 out out ADP njb-44 128 10 the the DET njb-44 128 11 homodimerization homodimerization NOUN njb-44 128 12 as as ADP njb-44 128 13 a a DET njb-44 128 14 requirement requirement NOUN njb-44 128 15 for for ADP njb-44 128 16 tcr tcr PROPN njb-44 128 17 triggering trigger VERB njb-44 128 18 . . PUNCT njb-44 129 1 it it PRON njb-44 129 2 is be AUX njb-44 129 3 possible possible ADJ njb-44 129 4 that that SCONJ njb-44 129 5 cd3 cd3 PROPN njb-44 129 6 itams itams PROPN njb-44 129 7 are be AUX njb-44 129 8 inaccessible inaccessible ADJ njb-44 129 9 for for ADP njb-44 129 10 phosphorylation phosphorylation NOUN njb-44 129 11 by by ADP njb-44 129 12 the the DET njb-44 129 13 kinase kinase NOUN njb-44 129 14 in in ADP njb-44 129 15 the the DET njb-44 129 16 resting rest VERB njb-44 129 17 state state NOUN njb-44 129 18 and and CCONJ njb-44 129 19 some some DET njb-44 129 20 sort sort NOUN njb-44 129 21 of of ADP njb-44 129 22 conformational conformational ADJ njb-44 129 23 change change NOUN njb-44 129 24 is be AUX njb-44 129 25 necessary necessary ADJ njb-44 129 26 for for ADP njb-44 129 27 exposing expose VERB njb-44 129 28 the the DET njb-44 129 29 itams itams PROPN njb-44 129 30 , , PUNCT njb-44 129 31 but but CCONJ njb-44 129 32 additional additional ADJ njb-44 129 33 studies study NOUN njb-44 129 34 are be AUX njb-44 129 35 required require VERB njb-44 129 36 to to PART njb-44 129 37 find find VERB njb-44 129 38 out out ADP njb-44 129 39 what what PRON njb-44 129 40 mechanism mechanism NOUN njb-44 129 41 is be AUX njb-44 129 42 responsible responsible ADJ njb-44 129 43 for for ADP njb-44 129 44 such such ADJ njb-44 129 45 conformational conformational ADJ njb-44 129 46 change change NOUN njb-44 129 47 . . PUNCT njb-44 130 1 segregation segregation NOUN njb-44 130 2 models model NOUN njb-44 130 3 argue argue VERB njb-44 130 4 the the DET njb-44 130 5 balance balance NOUN njb-44 130 6 of of ADP njb-44 130 7 kinase kinase NOUN njb-44 130 8 mediated mediate VERB njb-44 130 9 phosphorylation phosphorylation NOUN njb-44 130 10 and and CCONJ njb-44 130 11 phosphatase phosphatase NOUN njb-44 130 12 mediated mediate VERB njb-44 130 13 dephosphorylation dephosphorylation NOUN njb-44 130 14 shifts shift NOUN njb-44 130 15 in in ADP njb-44 130 16 favour favour NOUN njb-44 130 17 of of ADP njb-44 130 18 kinase kinase NOUN njb-44 130 19 upon upon SCONJ njb-44 130 20 ligand ligand NOUN njb-44 130 21 binding binding NOUN njb-44 130 22 . . PUNCT njb-44 131 1 though though SCONJ njb-44 131 2 such such ADJ njb-44 131 3 segregation segregation NOUN njb-44 131 4 might might AUX njb-44 131 5 contribute contribute VERB njb-44 131 6 for for ADP njb-44 131 7 tcr tcr PROPN njb-44 131 8 triggering trigger VERB njb-44 131 9 in in ADP njb-44 131 10 the the DET njb-44 131 11 context context NOUN njb-44 131 12 of of ADP njb-44 131 13 a a DET njb-44 131 14 t t NOUN njb-44 131 15 cell cell NOUN njb-44 131 16 - - PUNCT njb-44 131 17 antigen antigen NOUN njb-44 131 18 presenting present VERB njb-44 131 19 cell cell NOUN njb-44 131 20 interaction interaction NOUN njb-44 131 21 , , PUNCT njb-44 131 22 it it PRON njb-44 131 23 seems seem VERB njb-44 131 24 not not PART njb-44 131 25 the the DET njb-44 131 26 sole sole ADJ njb-44 131 27 mechanism mechanism NOUN njb-44 131 28 of of ADP njb-44 131 29 tcr tcr PROPN njb-44 131 30 triggering trigger VERB njb-44 131 31 as as ADP njb-44 131 32 the the DET njb-44 131 33 soluble soluble ADJ njb-44 131 34 anti anti NOUN njb-44 131 35 - - NOUN njb-44 131 36 tcr tcr NOUN njb-44 131 37 or or CCONJ njb-44 131 38 anti anti ADJ njb-44 131 39 - - ADJ njb-44 131 40 cd3 cd3 ADJ njb-44 131 41 antibodies antibody NOUN njb-44 131 42 which which PRON njb-44 131 43 do do AUX njb-44 131 44 not not PART njb-44 131 45 induce induce VERB njb-44 131 46 segregation segregation NOUN njb-44 131 47 can can AUX njb-44 131 48 still still ADV njb-44 131 49 cause cause VERB njb-44 131 50 tcr tcr PROPN njb-44 131 51 triggering trigger VERB njb-44 131 52 . . PUNCT njb-44 132 1 further further ADJ njb-44 132 2 studies study NOUN njb-44 132 3 on on ADP njb-44 132 4 the the DET njb-44 132 5 structure structure NOUN njb-44 132 6 of of ADP njb-44 132 7 fully fully ADV njb-44 132 8 assembled assemble VERB njb-44 132 9 tcr tcr PROPN njb-44 132 10 - - PUNCT njb-44 132 11 cd3 cd3 PROPN njb-44 132 12 complex complex NOUN njb-44 132 13 will will AUX njb-44 132 14 be be AUX njb-44 132 15 required require VERB njb-44 132 16 for for ADP njb-44 132 17 a a DET njb-44 132 18 better well ADJ njb-44 132 19 understanding understanding NOUN njb-44 132 20 of of ADP njb-44 132 21 the the DET njb-44 132 22 tcr tcr PROPN njb-44 132 23 triggering trigger VERB njb-44 132 24 . . PUNCT njb-44 133 1 references reference NOUN njb-44 133 2 1 1 NUM njb-44 133 3 . . PUNCT njb-44 133 4 call call VERB njb-44 133 5     SPACE njb-44 133 6 me i PRON njb-44 133 7 , , PUNCT njb-44 133 8     SPACE njb-44 133 9 pyrdol pyrdol PROPN njb-44 133 10     SPACE njb-44 133 11 j j PROPN njb-44 133 12 , , PUNCT njb-44 133 13     SPACE njb-44 133 14 wiedmann wiedmann PROPN njb-44 133 15     SPACE njb-44 133 16 m m PROPN njb-44 133 17 , , PUNCT njb-44 133 18     SPACE njb-44 133 19 wucherpfennig wucherpfennig PROPN njb-44 133 20     SPACE njb-44 133 21 kw kw NOUN njb-44 133 22 : : PUNCT njb-44 133 23     SPACE njb-44 133 24 the the DET njb-44 133 25     SPACE njb-44 133 26 organizing organizing NOUN njb-44 133 27     SPACE njb-44 133 28 principle principle NOUN njb-44 133 29     SPACE njb-44 133 30 in in ADP njb-44 133 31     SPACE njb-44 133 32 the the DET njb-44 133 33     SPACE njb-44 133 34 formation formation NOUN njb-44 133 35     SPACE njb-44 133 36 of of ADP njb-44 133 37     SPACE njb-44 133 38 the the DET njb-44 133 39     SPACE njb-44 133 40 t t PROPN njb-44 133 41     SPACE njb-44 133 42 cell cell NOUN njb-44 133 43     SPACE njb-44 133 44 receptor-­‐cd3 receptor-­‐cd3 VERB njb-44 133 45     SPACE njb-44 133 46 complex complex ADJ njb-44 133 47 . . PUNCT njb-44 133 48     SPACE njb-44 134 1 cell cell NOUN njb-44 134 2     SPACE njb-44 134 3 2002 2002 NUM njb-44 134 4 , , PUNCT njb-44 134 5     SPACE njb-44 134 6 111:967-­‐979 111:967-­‐979 NUM njb-44 134 7 . . PUNCT njb-44 134 8         SPACE njb-44 135 1 2 2 X njb-44 135 2 . . PROPN njb-44 135 3 smith-­‐garvin smith-­‐garvin PROPN njb-44 135 4     SPACE njb-44 135 5 je je PROPN njb-44 135 6 , , PUNCT njb-44 135 7     SPACE njb-44 135 8 koretzky koretzky PROPN njb-44 135 9     SPACE njb-44 135 10 ga ga PROPN njb-44 135 11 , , PUNCT njb-44 135 12     SPACE njb-44 135 13 jordan jordan PROPN njb-44 135 14     SPACE njb-44 135 15 ms ms PROPN njb-44 135 16 : : PUNCT njb-44 135 17     SPACE njb-44 135 18 t t PROPN njb-44 135 19     SPACE njb-44 135 20 cell cell NOUN njb-44 135 21     SPACE njb-44 135 22 activation activation NOUN njb-44 135 23 . . PUNCT njb-44 135 24     SPACE njb-44 136 1 annu annu NOUN njb-44 136 2     SPACE njb-44 136 3 rev rev PROPN njb-44 136 4     SPACE njb-44 136 5 immunol immunol NOUN njb-44 136 6     SPACE njb-44 136 7 2009 2009 NUM njb-44 136 8 , , PUNCT njb-44 136 9     SPACE njb-44 136 10 27:591-­‐ 27:591-­‐ NUM njb-44 136 11 619 619 NUM njb-44 136 12 . . PUNCT njb-44 136 13         SPACE njb-44 137 1 3 3 X njb-44 137 2 . . X njb-44 137 3 cochran cochran PROPN njb-44 137 4     SPACE njb-44 137 5 jr jr PROPN njb-44 137 6 , , PUNCT njb-44 137 7     SPACE njb-44 137 8 aivazian aivazian PROPN njb-44 137 9     SPACE njb-44 137 10 d d PROPN njb-44 137 11 , , PUNCT njb-44 137 12     SPACE njb-44 137 13 cameron cameron PROPN njb-44 137 14     SPACE njb-44 137 15 to to ADP njb-44 137 16 , , PUNCT njb-44 137 17     SPACE njb-44 137 18 stern stern ADJ njb-44 137 19     SPACE njb-44 137 20 lj lj PROPN njb-44 137 21 : : PUNCT njb-44 137 22     SPACE njb-44 137 23 receptor receptor NOUN njb-44 137 24     SPACE njb-44 137 25 clustering clustering NOUN njb-44 137 26     SPACE njb-44 137 27 and and CCONJ njb-44 137 28     SPACE njb-44 137 29 transmembrane transmembrane NOUN njb-44 137 30     SPACE njb-44 137 31 signaling signal VERB njb-44 137 32     SPACE njb-44 137 33 in in ADP njb-44 137 34     SPACE njb-44 137 35 t t NOUN njb-44 137 36     SPACE njb-44 137 37 cells cell NOUN njb-44 137 38 . . PUNCT njb-44 137 39     SPACE njb-44 138 1 trends trend NOUN njb-44 138 2     SPACE njb-44 138 3 biochem biochem NOUN njb-44 138 4     SPACE njb-44 138 5 sci sci PROPN njb-44 138 6     SPACE njb-44 138 7 2001 2001 NUM njb-44 138 8 , , PUNCT njb-44 138 9     SPACE njb-44 138 10 26(5):304-­‐310 26(5):304-­‐310 NUM njb-44 138 11 . . PUNCT njb-44 138 12         SPACE njb-44 139 1 4 4 X njb-44 139 2 . . PROPN njb-44 139 3 matko matko PROPN njb-44 139 4     SPACE njb-44 139 5 j j PROPN njb-44 139 6 , , PUNCT njb-44 139 7     SPACE njb-44 139 8 bushkin bushkin PROPN njb-44 139 9     SPACE njb-44 139 10 y y PROPN njb-44 139 11 , , PUNCT njb-44 139 12     SPACE njb-44 139 13 wei wei PROPN njb-44 139 14     SPACE njb-44 139 15 t t PROPN njb-44 139 16 , , PUNCT njb-44 139 17     SPACE njb-44 139 18 edidin edidin PROPN njb-44 139 19     SPACE njb-44 139 20 m m VERB njb-44 139 21 : : PUNCT njb-44 139 22     SPACE njb-44 139 23 clustering cluster VERB njb-44 139 24     SPACE njb-44 139 25 of of ADP njb-44 139 26     SPACE njb-44 139 27 class class NOUN njb-44 139 28     SPACE njb-44 139 29 i i PRON njb-44 139 30     SPACE njb-44 139 31 hla hla PROPN njb-44 139 32     SPACE njb-44 139 33 molecules molecule NOUN njb-44 139 34     SPACE njb-44 139 35 on on ADP njb-44 139 36     SPACE njb-44 139 37 the the DET njb-44 139 38     SPACE njb-44 139 39 surfaces surface NOUN njb-44 139 40     SPACE njb-44 139 41 of of ADP njb-44 139 42     SPACE njb-44 139 43 activated activate VERB njb-44 139 44     SPACE njb-44 139 45 and and CCONJ njb-44 139 46     SPACE njb-44 139 47 transformed transform VERB njb-44 139 48     SPACE njb-44 139 49 human human ADJ njb-44 139 50     SPACE njb-44 139 51 cells cell NOUN njb-44 139 52 . . PUNCT njb-44 139 53     SPACE njb-44 140 1 j j PROPN njb-44 140 2     SPACE njb-44 140 3 immunol immunol NOUN njb-44 140 4     SPACE njb-44 140 5 1994 1994 NUM njb-44 140 6 , , PUNCT njb-44 140 7     SPACE njb-44 140 8 152(7):3353-­‐3360 152(7):3353-­‐3360 NUM njb-44 140 9 . . PUNCT njb-44 140 10         SPACE njb-44 141 1 5 5 X njb-44 141 2 . . PUNCT njb-44 142 1 fooksman fooksman PROPN njb-44 142 2     SPACE njb-44 142 3 dr dr PROPN njb-44 142 4 , , PUNCT njb-44 142 5     SPACE njb-44 142 6 gronvall gronvall PROPN njb-44 142 7     SPACE njb-44 142 8 gk gk PROPN njb-44 142 9 , , PUNCT njb-44 142 10     SPACE njb-44 142 11 tang tang PROPN njb-44 142 12     SPACE njb-44 142 13 q q ADJ njb-44 142 14 , , PUNCT njb-44 142 15     SPACE njb-44 142 16 edidin edidin PROPN njb-44 142 17     SPACE njb-44 142 18 m m VERB njb-44 142 19 : : PUNCT njb-44 142 20     SPACE njb-44 142 21 clustering cluster VERB njb-44 142 22     SPACE njb-44 142 23 class class NOUN njb-44 142 24     SPACE njb-44 142 25 i i PRON njb-44 142 26     SPACE njb-44 142 27 mhc mhc ADJ njb-44 142 28     SPACE njb-44 142 29 modulates modulate VERB njb-44 142 30     SPACE njb-44 142 31 sensitivity sensitivity NOUN njb-44 142 32     SPACE njb-44 142 33 of of ADP njb-44 142 34     SPACE njb-44 142 35 t t NOUN njb-44 142 36     SPACE njb-44 142 37 cell cell NOUN njb-44 142 38     SPACE njb-44 142 39 recognition recognition NOUN njb-44 142 40 . . PUNCT njb-44 142 41     SPACE njb-44 143 1 journal journal PROPN njb-44 143 2     SPACE njb-44 143 3 of of ADP njb-44 143 4     SPACE njb-44 143 5 immunology immunology NOUN njb-44 143 6     SPACE njb-44 143 7 2006 2006 NUM njb-44 143 8 , , PUNCT njb-44 143 9     SPACE njb-44 143 10 176(11):6673-­‐6680 176(11):6673-­‐6680 NUM njb-44 143 11 . . PUNCT njb-44 143 12         SPACE njb-44 144 1 6 6 X njb-44 144 2 . . PUNCT njb-44 144 3 unternaehrer unternaehrer PROPN njb-44 144 4     SPACE njb-44 144 5 jj jj PROPN njb-44 144 6 , , PUNCT njb-44 144 7     SPACE njb-44 144 8 chow chow NOUN njb-44 144 9     SPACE njb-44 144 10 a a DET njb-44 144 11 , , PUNCT njb-44 144 12     SPACE njb-44 144 13 pypaert pypaert NOUN njb-44 144 14     SPACE njb-44 144 15 m m PROPN njb-44 144 16 , , PUNCT njb-44 144 17     SPACE njb-44 144 18 inaba inaba PROPN njb-44 144 19     SPACE njb-44 144 20 k k PROPN njb-44 144 21 , , PUNCT njb-44 144 22     SPACE njb-44 144 23 mellman mellman PROPN njb-44 144 24     SPACE njb-44 144 25 i i PRON njb-44 144 26 : : PUNCT njb-44 144 27     SPACE njb-44 144 28 the the DET njb-44 144 29     SPACE njb-44 144 30 tetraspanin tetraspanin PROPN njb-44 144 31     SPACE njb-44 144 32 cd9 cd9 NOUN njb-44 144 33     SPACE njb-44 144 34 mediates mediate VERB njb-44 144 35     SPACE njb-44 144 36 lateral lateral ADJ njb-44 144 37     SPACE njb-44 144 38 association association NOUN njb-44 144 39     SPACE njb-44 144 40 of of ADP njb-44 144 41     SPACE njb-44 144 42 mhc mhc ADJ njb-44 144 43     SPACE njb-44 144 44 class class NOUN njb-44 144 45     SPACE njb-44 144 46 ii ii PROPN njb-44 144 47     SPACE njb-44 144 48 molecules molecule NOUN njb-44 144 49     SPACE njb-44 144 50 on on ADP njb-44 144 51     SPACE njb-44 144 52 the the DET njb-44 144 53     SPACE njb-44 144 54 dendritic dendritic ADJ njb-44 144 55     SPACE njb-44 144 56 cell cell NOUN njb-44 144 57     SPACE njb-44 144 58 surface surface NOUN njb-44 144 59 . . PUNCT njb-44 144 60     SPACE njb-44 145 1 proceedings proceeding NOUN njb-44 145 2     SPACE njb-44 145 3 of of ADP njb-44 145 4     SPACE njb-44 145 5 the the DET njb-44 145 6     SPACE njb-44 145 7 national national PROPN njb-44 145 8     SPACE njb-44 145 9 academy academy PROPN njb-44 145 10     SPACE njb-44 145 11 of of ADP njb-44 145 12     SPACE njb-44 145 13 sciences science NOUN njb-44 145 14     SPACE njb-44 145 15 of of ADP njb-44 145 16     SPACE njb-44 145 17 the the DET njb-44 145 18     SPACE njb-44 145 19 united united PROPN njb-44 145 20     SPACE njb-44 145 21 states state NOUN njb-44 145 22     SPACE njb-44 145 23 of of ADP njb-44 145 24     SPACE njb-44 145 25 america america PROPN njb-44 145 26     SPACE njb-44 145 27 2007 2007 NUM njb-44 145 28 , , PUNCT njb-44 145 29     SPACE njb-44 145 30 104(1):234-­‐239 104(1):234-­‐239 NUM njb-44 145 31 . . PUNCT njb-44 145 32         SPACE njb-44 146 1 7 7 X njb-44 146 2 . . PROPN njb-44 146 3 schamel schamel PROPN njb-44 146 4     SPACE njb-44 146 5 ww ww PROPN njb-44 146 6 , , PUNCT njb-44 146 7     SPACE njb-44 146 8 arechaga arechaga NOUN njb-44 146 9     SPACE njb-44 146 10 i i PRON njb-44 146 11 , , PUNCT njb-44 146 12     SPACE njb-44 146 13 risueno risueno NOUN njb-44 146 14     SPACE njb-44 146 15 rm rm PROPN njb-44 146 16 , , PUNCT njb-44 146 17     SPACE njb-44 146 18 van van PROPN njb-44 146 19     SPACE njb-44 146 20 santen santen VERB njb-44 146 21     SPACE njb-44 146 22 hm hm INTJ njb-44 146 23 , , PUNCT njb-44 146 24     SPACE njb-44 146 25 cabezas cabeza VERB njb-44 146 26     SPACE njb-44 146 27 p p PROPN njb-44 146 28 , , PUNCT njb-44 146 29     SPACE njb-44 146 30 risco risco PROPN njb-44 146 31     SPACE njb-44 146 32 c c PROPN njb-44 146 33 , , PUNCT njb-44 146 34     SPACE njb-44 146 35 valpuesta valpuesta PROPN njb-44 146 36     SPACE njb-44 146 37 jm jm PROPN njb-44 146 38 , , PUNCT njb-44 146 39     SPACE njb-44 146 40 alarcon alarcon PROPN njb-44 146 41     SPACE njb-44 146 42 b b PROPN njb-44 146 43 : : PUNCT njb-44 146 44     SPACE njb-44 146 45 coexistence coexistence NOUN njb-44 146 46     SPACE njb-44 146 47 of of ADP njb-44 146 48     SPACE njb-44 146 49 multivalent multivalent ADJ njb-44 146 50     SPACE njb-44 146 51 and and CCONJ njb-44 146 52     SPACE njb-44 146 53 monovalent monovalent NOUN njb-44 146 54     SPACE njb-44 146 55 tcrs tcrs NOUN njb-44 146 56     SPACE njb-44 146 57 explains explain VERB njb-44 146 58     SPACE njb-44 146 59 high high ADJ njb-44 146 60     SPACE njb-44 146 61 sensitivity sensitivity NOUN njb-44 146 62     SPACE njb-44 146 63 and and CCONJ njb-44 146 64     SPACE njb-44 146 65 wide wide ADJ njb-44 146 66     SPACE njb-44 146 67 range range NOUN njb-44 146 68     SPACE njb-44 146 69 of of ADP njb-44 146 70     SPACE njb-44 146 71 response response NOUN njb-44 146 72 . . PUNCT njb-44 146 73     SPACE njb-44 147 1 j j PROPN njb-44 147 2     SPACE njb-44 147 3 exp exp PROPN njb-44 147 4     SPACE njb-44 147 5 med me VERB njb-44 147 6     SPACE njb-44 147 7 2005 2005 NUM njb-44 147 8 , , PUNCT njb-44 147 9     SPACE njb-44 147 10 202:493-­‐503 202:493-­‐503 NUM njb-44 147 11 . . PUNCT njb-44 147 12         SPACE njb-44 148 1 8 8 NUM njb-44 148 2 . . PUNCT njb-44 149 1 lillemeier lillemei ADJ njb-44 149 2     SPACE njb-44 149 3 bf bf NOUN njb-44 149 4 , , PUNCT njb-44 149 5     SPACE njb-44 149 6 mortelmaier mortelmaier PROPN njb-44 149 7     SPACE njb-44 149 8 ma ma PROPN njb-44 149 9 , , PUNCT njb-44 149 10     SPACE njb-44 149 11 forstner forstner ADJ njb-44 149 12     SPACE njb-44 149 13 mb mb PROPN njb-44 149 14 , , PUNCT njb-44 149 15     SPACE njb-44 149 16 huppa huppa PROPN njb-44 149 17     SPACE njb-44 149 18 jb jb PROPN njb-44 149 19 , , PUNCT njb-44 149 20     SPACE njb-44 149 21 groves grove NOUN njb-44 149 22     SPACE njb-44 149 23 jt jt PROPN njb-44 149 24 , , PUNCT njb-44 149 25     SPACE njb-44 149 26 davis davis PROPN njb-44 149 27     SPACE njb-44 149 28 mm mm PROPN njb-44 149 29 : : PUNCT njb-44 149 30     SPACE njb-44 149 31 tcr tcr PROPN njb-44 149 32     SPACE njb-44 149 33 and and CCONJ njb-44 149 34     SPACE njb-44 149 35 lat lat PROPN njb-44 149 36     SPACE njb-44 149 37 are be AUX njb-44 149 38     SPACE njb-44 149 39 expressed express VERB njb-44 149 40     SPACE njb-44 149 41 on on ADP njb-44 149 42     SPACE njb-44 149 43 separate separate ADJ njb-44 149 44     SPACE njb-44 149 45 protein protein NOUN njb-44 149 46     SPACE njb-44 149 47 islands island NOUN njb-44 149 48     SPACE njb-44 149 49 on on ADP njb-44 149 50     SPACE njb-44 149 51 t t NOUN njb-44 149 52     SPACE njb-44 149 53 cell cell NOUN njb-44 149 54     SPACE njb-44 149 55 membranes membrane NOUN njb-44 149 56     SPACE njb-44 149 57 and and CCONJ njb-44 149 58     SPACE njb-44 149 59 concatenate concatenate VERB njb-44 149 60     SPACE njb-44 149 61 during during ADP njb-44 149 62     SPACE njb-44 149 63 activation activation NOUN njb-44 149 64 . . PUNCT njb-44 149 65     SPACE njb-44 150 1 nat nat PROPN njb-44 150 2     SPACE njb-44 150 3 immunol immunol NOUN njb-44 150 4     SPACE njb-44 150 5 2010 2010 NUM njb-44 150 6 , , PUNCT njb-44 150 7     SPACE njb-44 150 8 11(1):90-­‐96 11(1):90-­‐96 NUM njb-44 150 9 . . PUNCT njb-44 150 10         SPACE njb-44 151 1 9 9 X njb-44 151 2 . . PUNCT njb-44 152 1 minguet minguet PROPN njb-44 152 2     SPACE njb-44 152 3 s s PROPN njb-44 152 4 , , PUNCT njb-44 152 5     SPACE njb-44 152 6 swamy swamy ADJ njb-44 152 7     SPACE njb-44 152 8 m m VERB njb-44 152 9 , , PUNCT njb-44 152 10     SPACE njb-44 152 11 alarcon alarcon PROPN njb-44 152 12     SPACE njb-44 152 13 b b PROPN njb-44 152 14 , , PUNCT njb-44 152 15     SPACE njb-44 152 16 luescher luescher NOUN njb-44 152 17     SPACE njb-44 153 1 if if SCONJ njb-44 153 2 , , PUNCT njb-44 153 3     SPACE njb-44 153 4 schamel schamel PROPN njb-44 153 5     SPACE njb-44 153 6 ww ww PROPN njb-44 153 7 : : PUNCT njb-44 153 8     SPACE njb-44 153 9 full full ADJ njb-44 153 10     SPACE njb-44 153 11 activation activation NOUN njb-44 153 12     SPACE njb-44 153 13 of of ADP njb-44 153 14     SPACE njb-44 153 15 the the DET njb-44 153 16     SPACE njb-44 153 17 t t PROPN njb-44 153 18     SPACE njb-44 153 19 cell cell NOUN njb-44 153 20     SPACE njb-44 153 21 receptor receptor NOUN njb-44 153 22     SPACE njb-44 153 23 requires require VERB njb-44 153 24     SPACE njb-44 153 25 both both PRON njb-44 153 26     SPACE njb-44 153 27 clustering clustering NOUN njb-44 153 28     SPACE njb-44 153 29 and and CCONJ njb-44 153 30     SPACE njb-44 153 31 nepal nepal ADJ njb-44 153 32     SPACE njb-44 153 33 journal journal NOUN njb-44 153 34     SPACE njb-44 153 35 of of ADP njb-44 153 36     SPACE njb-44 153 37 biotechnology biotechnology NOUN njb-44 153 38 . . PUNCT njb-44 153 39         SPACE njb-44 154 1 jan jan PROPN njb-44 154 2     SPACE njb-44 154 3 2012 2012 NUM njb-44 154 4 , , PUNCT njb-44 154 5     SPACE njb-44 154 6 vol vol NOUN njb-44 154 7 . . PUNCT njb-44 154 8     SPACE njb-44 155 1 2 2 NUM njb-44 155 2 , , PUNCT njb-44 155 3     SPACE njb-44 155 4 no no INTJ njb-44 155 5 . . PUNCT njb-44 155 6     SPACE njb-44 156 1 1 1 NUM njb-44 156 2 : : PUNCT njb-44 156 3     SPACE njb-44 156 4 62 62 NUM njb-44 156 5     SPACE njb-44 156 6 – – PUNCT njb-44 156 7     SPACE njb-44 156 8 71 71 NUM njb-44 156 9                                                                                                                                                                                                                                         SPACE njb-44 156 10 biotechnology biotechnology NOUN njb-44 156 11     SPACE njb-44 156 12 society society NOUN njb-44 156 13     SPACE njb-44 156 14 of of ADP njb-44 156 15     SPACE njb-44 156 16 nepal nepal NOUN njb-44 156 17     SPACE njb-44 156 18 ( ( PUNCT njb-44 156 19 bsn bsn PROPN njb-44 156 20 ) ) PUNCT njb-44 156 21 , , PUNCT njb-44 156 22     SPACE njb-44 156 23 all all DET njb-44 156 24     SPACE njb-44 156 25 rights right NOUN njb-44 156 26     SPACE njb-44 156 27 reserved reserve VERB njb-44 156 28     SPACE njb-44 156 29 70 70 NUM njb-44 156 30 conformational conformational ADJ njb-44 156 31     SPACE njb-44 156 32 changes change NOUN njb-44 156 33     SPACE njb-44 156 34 at at ADP njb-44 156 35     SPACE njb-44 156 36 cd3 cd3 PROPN njb-44 156 37 . . PUNCT njb-44 156 38     SPACE njb-44 157 1 immunity immunity NOUN njb-44 157 2     SPACE njb-44 157 3 2007 2007 NUM njb-44 157 4 , , PUNCT njb-44 157 5     SPACE njb-44 157 6 26(1):43-­‐54 26(1):43-­‐54 NUM njb-44 157 7 . . PUNCT njb-44 157 8         SPACE njb-44 158 1 10 10 NUM njb-44 158 2 . . PUNCT njb-44 159 1 trautmann trautmann PROPN njb-44 159 2     SPACE njb-44 159 3 a a PRON njb-44 159 4 , , PUNCT njb-44 159 5     SPACE njb-44 160 1 randriamampita randriamampita PROPN njb-44 160 2     SPACE njb-44 160 3 c c PROPN njb-44 160 4 : : PUNCT njb-44 160 5     SPACE njb-44 161 1 initiation initiation NOUN njb-44 161 2     SPACE njb-44 161 3 of of ADP njb-44 161 4     SPACE njb-44 161 5 tcr tcr PROPN njb-44 161 6     SPACE njb-44 161 7 signalling signal VERB njb-44 161 8     SPACE njb-44 161 9 revisited revisit VERB njb-44 161 10 . . PUNCT njb-44 161 11     SPACE njb-44 162 1 trends trend NOUN njb-44 162 2     SPACE njb-44 162 3 immunol immunol NOUN njb-44 162 4     SPACE njb-44 162 5 2003 2003 NUM njb-44 162 6 , , PUNCT njb-44 162 7     SPACE njb-44 162 8 24(8):425-­‐428 24(8):425-­‐428 NUM njb-44 162 9 . . PUNCT njb-44 162 10         SPACE njb-44 163 1 11 11 NUM njb-44 163 2 . . PUNCT njb-44 164 1 palmer palmer PROPN njb-44 164 2     SPACE njb-44 164 3 e e PROPN njb-44 164 4 , , PUNCT njb-44 164 5     SPACE njb-44 164 6 naeher naeher ADJ njb-44 164 7     SPACE njb-44 164 8 d d PROPN njb-44 164 9 : : PUNCT njb-44 164 10     SPACE njb-44 164 11 affinity affinity NOUN njb-44 164 12     SPACE njb-44 164 13 threshold threshold NOUN njb-44 164 14     SPACE njb-44 164 15 for for ADP njb-44 164 16     SPACE njb-44 164 17 thymic thymic ADJ njb-44 164 18     SPACE njb-44 164 19 selection selection NOUN njb-44 164 20     SPACE njb-44 164 21 through through ADP njb-44 164 22     SPACE njb-44 164 23 a a DET njb-44 164 24     SPACE njb-44 164 25 t-­‐cell t-­‐cell PROPN njb-44 164 26     SPACE njb-44 164 27 receptor-­‐co-­‐ receptor-­‐co-­‐ PROPN njb-44 164 28 receptor receptor NOUN njb-44 164 29     SPACE njb-44 164 30 zipper zipper NOUN njb-44 164 31 . . PUNCT njb-44 164 32     SPACE njb-44 165 1 nat nat PROPN njb-44 165 2     SPACE njb-44 165 3 rev rev PROPN njb-44 165 4     SPACE njb-44 165 5 immunol immunol NOUN njb-44 165 6     SPACE njb-44 165 7 2009 2009 NUM njb-44 165 8 , , PUNCT njb-44 165 9     SPACE njb-44 165 10 9(3):207-­‐213 9(3):207-­‐213 NUM njb-44 165 11 . . PUNCT njb-44 165 12         SPACE njb-44 166 1 12 12 NUM njb-44 166 2 . . PUNCT njb-44 167 1 locksley locksley PROPN njb-44 167 2     SPACE njb-44 167 3 rm rm PROPN njb-44 167 4 , , PUNCT njb-44 167 5     SPACE njb-44 167 6 reiner reiner PROPN njb-44 167 7     SPACE njb-44 167 8 sl sl PROPN njb-44 167 9 , , PUNCT njb-44 167 10     SPACE njb-44 167 11 hatam hatam NOUN njb-44 167 12     SPACE njb-44 167 13 f f PROPN njb-44 167 14 , , PUNCT njb-44 167 15     SPACE njb-44 167 16 littman littman PROPN njb-44 167 17     SPACE njb-44 167 18 dr dr PROPN njb-44 167 19 , , PUNCT njb-44 167 20     SPACE njb-44 167 21 killeen killeen VERB njb-44 167 22     SPACE njb-44 167 23 n n ADV njb-44 167 24 : : PUNCT njb-44 167 25     SPACE njb-44 167 26 helper helper VERB njb-44 167 27     SPACE njb-44 167 28 t t NOUN njb-44 167 29     SPACE njb-44 167 30 cells cell NOUN njb-44 167 31     SPACE njb-44 167 32 without without ADP njb-44 167 33     SPACE njb-44 167 34 cd4 cd4 NOUN njb-44 167 35 : : PUNCT njb-44 167 36     SPACE njb-44 167 37 control control NOUN njb-44 167 38     SPACE njb-44 167 39 of of ADP njb-44 167 40     SPACE njb-44 167 41 leishmaniasis leishmaniasis NOUN njb-44 167 42     SPACE njb-44 167 43 in in ADP njb-44 167 44     SPACE njb-44 167 45 cd4-­‐deficient cd4-­‐deficient ADJ njb-44 167 46     SPACE njb-44 167 47 mice mouse NOUN njb-44 167 48 . . PUNCT njb-44 167 49     SPACE njb-44 168 1 science science NOUN njb-44 168 2     SPACE njb-44 168 3 1993 1993 NUM njb-44 168 4 , , PUNCT njb-44 168 5     SPACE njb-44 168 6 261(5127):1448-­‐1451 261(5127):1448-­‐1451 NUM njb-44 168 7 . . PUNCT njb-44 168 8         SPACE njb-44 169 1 13 13 NUM njb-44 169 2 . . PUNCT njb-44 170 1 schilham schilham PROPN njb-44 170 2     SPACE njb-44 170 3 mw mw PROPN njb-44 170 4 , , PUNCT njb-44 170 5     SPACE njb-44 170 6 fung-­‐leung fung-­‐leung PROPN njb-44 170 7     SPACE njb-44 170 8 wp wp PROPN njb-44 170 9 , , PUNCT njb-44 170 10     SPACE njb-44 170 11 rahemtulla rahemtulla PROPN njb-44 170 12     SPACE njb-44 170 13 a a PRON njb-44 170 14 , , PUNCT njb-44 170 15     SPACE njb-44 170 16 kuendig kuendig PROPN njb-44 170 17     SPACE njb-44 170 18 t t PROPN njb-44 170 19 , , PUNCT njb-44 170 20     SPACE njb-44 170 21 zhang zhang PROPN njb-44 170 22     SPACE njb-44 170 23 l l NOUN njb-44 170 24 , , PUNCT njb-44 170 25     SPACE njb-44 170 26 potter potter NOUN njb-44 170 27     SPACE njb-44 170 28 j j PROPN njb-44 170 29 , , PUNCT njb-44 170 30     SPACE njb-44 170 31 miller miller PROPN njb-44 170 32     SPACE njb-44 170 33 rg rg PROPN njb-44 170 34 , , PUNCT njb-44 170 35     SPACE njb-44 170 36 hengartner hengartner NOUN njb-44 170 37     SPACE njb-44 170 38 h h PROPN njb-44 170 39 , , PUNCT njb-44 170 40     SPACE njb-44 170 41 mak mak PROPN njb-44 170 42     SPACE njb-44 170 43 tw tw PROPN njb-44 170 44 : : PUNCT njb-44 170 45     SPACE njb-44 170 46 alloreactive alloreactive ADJ njb-44 170 47     SPACE njb-44 170 48 cytotoxic cytotoxic NOUN njb-44 170 49     SPACE njb-44 170 50 t t NOUN njb-44 170 51     SPACE njb-44 170 52 cells cell NOUN njb-44 170 53     SPACE njb-44 170 54 can can AUX njb-44 170 55     SPACE njb-44 170 56 develop develop VERB njb-44 170 57     SPACE njb-44 170 58 and and CCONJ njb-44 170 59     SPACE njb-44 170 60 function function VERB njb-44 170 61     SPACE njb-44 170 62 in in ADP njb-44 170 63     SPACE njb-44 170 64 mice mouse NOUN njb-44 170 65     SPACE njb-44 170 66 lacking lack VERB njb-44 170 67     SPACE njb-44 170 68 both both PRON njb-44 170 69     SPACE njb-44 170 70 cd4 cd4 NOUN njb-44 170 71     SPACE njb-44 170 72 and and CCONJ njb-44 170 73     SPACE njb-44 170 74 cd8 cd8 PROPN njb-44 170 75 . . PUNCT njb-44 170 76     SPACE njb-44 171 1 european european PROPN njb-44 171 2     SPACE njb-44 171 3 journal journal PROPN njb-44 171 4     SPACE njb-44 171 5 of of ADP njb-44 171 6     SPACE njb-44 171 7 immunology immunology NOUN njb-44 171 8     SPACE njb-44 171 9 1993 1993 NUM njb-44 171 10 , , PUNCT njb-44 171 11     SPACE njb-44 171 12 23(6):1299-­‐1304 23(6):1299-­‐1304 NUM njb-44 171 13 . . PUNCT njb-44 171 14         SPACE njb-44 172 1 14 14 NUM njb-44 172 2 . . PUNCT njb-44 173 1 chang chang PROPN njb-44 173 2     SPACE njb-44 173 3 tw tw PROPN njb-44 173 4 , , PUNCT njb-44 173 5     SPACE njb-44 173 6 kung kung PROPN njb-44 173 7     SPACE njb-44 173 8 pc pc PROPN njb-44 173 9 , , PUNCT njb-44 173 10     SPACE njb-44 173 11 gingras gingras PROPN njb-44 173 12     SPACE njb-44 173 13 sp sp PROPN njb-44 173 14 , , PUNCT njb-44 173 15     SPACE njb-44 173 16 goldstein goldstein PROPN njb-44 173 17     SPACE njb-44 173 18 g g PROPN njb-44 173 19 : : PUNCT njb-44 173 20     SPACE njb-44 173 21 does do AUX njb-44 173 22     SPACE njb-44 173 23 okt3 okt3 NOUN njb-44 173 24     SPACE njb-44 173 25 monoclonal monoclonal NOUN njb-44 173 26     SPACE njb-44 173 27 antibody antibody NOUN njb-44 173 28     SPACE njb-44 173 29 react react VERB njb-44 173 30     SPACE njb-44 173 31 with with ADP njb-44 173 32     SPACE njb-44 173 33 an an DET njb-44 173 34     SPACE njb-44 173 35 antigen-­‐recognition antigen-­‐recognition NOUN njb-44 173 36     SPACE njb-44 173 37 structure structure NOUN njb-44 173 38     SPACE njb-44 173 39 on on ADP njb-44 173 40     SPACE njb-44 173 41 human human NOUN njb-44 173 42     SPACE njb-44 173 43 t t NOUN njb-44 173 44     SPACE njb-44 173 45 cells cell NOUN njb-44 173 46 ? ? PUNCT njb-44 173 47     SPACE njb-44 174 1 proc proc NOUN njb-44 174 2     SPACE njb-44 174 3 natl natl PROPN njb-44 174 4     SPACE njb-44 174 5 acad acad PROPN njb-44 174 6     SPACE njb-44 174 7 sci sci PROPN njb-44 174 8     SPACE njb-44 174 9 u u PROPN njb-44 174 10     SPACE njb-44 174 11 s s PART njb-44 174 12     SPACE njb-44 174 13 a a DET njb-44 174 14     SPACE njb-44 174 15 1981 1981 NUM njb-44 174 16 , , PUNCT njb-44 174 17     SPACE njb-44 174 18 78(3):1805-­‐ 78(3):1805-­‐ NUM njb-44 174 19 1808 1808 NUM njb-44 174 20 . . PUNCT njb-44 174 21         SPACE njb-44 175 1 15 15 X njb-44 175 2 . . PUNCT njb-44 175 3 kaye kaye NOUN njb-44 175 4     SPACE njb-44 175 5 j j PROPN njb-44 175 6 , , PUNCT njb-44 175 7     SPACE njb-44 175 8 janeway janeway NOUN njb-44 175 9     SPACE njb-44 175 10 ca can AUX njb-44 175 11 , , PUNCT njb-44 175 12     SPACE njb-44 175 13 jr jr PROPN njb-44 175 14 . . PROPN njb-44 175 15 : : PUNCT njb-44 175 16     SPACE njb-44 175 17 the the DET njb-44 175 18     SPACE njb-44 175 19 fab fab PROPN njb-44 175 20     SPACE njb-44 175 21 fragment fragment NOUN njb-44 175 22     SPACE njb-44 175 23 of of ADP njb-44 175 24     SPACE njb-44 175 25 a a PRON njb-44 175 26     SPACE njb-44 175 27 directly directly ADV njb-44 175 28     SPACE njb-44 175 29 activating activate VERB njb-44 175 30     SPACE njb-44 175 31 monoclonal monoclonal NOUN njb-44 175 32     SPACE njb-44 175 33 antibody antibody NOUN njb-44 175 34     SPACE njb-44 175 35 that that PRON njb-44 175 36     SPACE njb-44 175 37 precipitates precipitate VERB njb-44 175 38     SPACE njb-44 175 39 a a DET njb-44 175 40     SPACE njb-44 175 41 disulfide-­‐linked disulfide-­‐linke VERB njb-44 175 42     SPACE njb-44 175 43 heterodimer heterodimer NOUN njb-44 175 44     SPACE njb-44 175 45 from from ADP njb-44 175 46     SPACE njb-44 175 47 a a DET njb-44 175 48     SPACE njb-44 175 49 helper helper NOUN njb-44 175 50     SPACE njb-44 175 51 t t NOUN njb-44 175 52     SPACE njb-44 175 53 cell cell NOUN njb-44 175 54     SPACE njb-44 175 55 clone clone NOUN njb-44 175 56     SPACE njb-44 175 57 blocks block VERB njb-44 175 58     SPACE njb-44 175 59 activation activation NOUN njb-44 175 60     SPACE njb-44 175 61 by by ADP njb-44 175 62     SPACE njb-44 175 63 either either CCONJ njb-44 175 64     SPACE njb-44 175 65 allogeneic allogeneic ADJ njb-44 175 66     SPACE njb-44 175 67 ia ia PROPN njb-44 175 68     SPACE njb-44 175 69 or or CCONJ njb-44 175 70     SPACE njb-44 175 71 antigen antigen NOUN njb-44 175 72     SPACE njb-44 175 73 and and CCONJ njb-44 175 74     SPACE njb-44 175 75 self-­‐ia self-­‐ia PROPN njb-44 175 76 . . PUNCT njb-44 175 77     SPACE njb-44 176 1 j j PROPN njb-44 176 2     SPACE njb-44 176 3 exp exp PROPN njb-44 176 4     SPACE njb-44 176 5 med me VERB njb-44 176 6     SPACE njb-44 176 7 1984 1984 NUM njb-44 176 8 , , PUNCT njb-44 176 9     SPACE njb-44 176 10 159(5):1397-­‐1412 159(5):1397-­‐1412 NUM njb-44 176 11 . . PUNCT njb-44 176 12         SPACE njb-44 177 1 16 16 NUM njb-44 177 2 . . PUNCT njb-44 178 1 krogsgaard krogsgaard NOUN njb-44 178 2     SPACE njb-44 178 3 m m PROPN njb-44 178 4 , , PUNCT njb-44 178 5     SPACE njb-44 178 6 li li PROPN njb-44 178 7     SPACE njb-44 178 8 qj qj PROPN njb-44 178 9 , , PUNCT njb-44 178 10     SPACE njb-44 178 11 sumen suman NOUN njb-44 178 12     SPACE njb-44 178 13 c c PROPN njb-44 178 14 , , PUNCT njb-44 178 15     SPACE njb-44 178 16 huppa huppa PROPN njb-44 178 17     SPACE njb-44 178 18 jb jb PROPN njb-44 178 19 , , PUNCT njb-44 178 20     SPACE njb-44 178 21 huse huse VERB njb-44 178 22     SPACE njb-44 178 23 m m ADP njb-44 178 24 , , PUNCT njb-44 178 25     SPACE njb-44 178 26 davis davis PROPN njb-44 178 27     SPACE njb-44 178 28 mm mm PROPN njb-44 178 29 : : PUNCT njb-44 178 30     SPACE njb-44 178 31 agonist agonist NOUN njb-44 178 32 / / SYM njb-44 178 33 endogenous endogenous ADJ njb-44 178 34     SPACE njb-44 178 35 peptide-­‐ peptide-­‐ NOUN njb-44 178 36 mhc mhc ADJ njb-44 178 37     SPACE njb-44 178 38 heterodimers heterodimer NOUN njb-44 178 39     SPACE njb-44 178 40 drive drive VERB njb-44 178 41     SPACE njb-44 178 42 t t NOUN njb-44 178 43     SPACE njb-44 178 44 cell cell NOUN njb-44 178 45     SPACE njb-44 178 46 activation activation NOUN njb-44 178 47     SPACE njb-44 178 48 and and CCONJ njb-44 178 49     SPACE njb-44 178 50 sensitivity sensitivity NOUN njb-44 178 51 . . PUNCT njb-44 178 52     SPACE njb-44 179 1 nature nature NOUN njb-44 179 2     SPACE njb-44 179 3 2005 2005 NUM njb-44 179 4 , , PUNCT njb-44 179 5     SPACE njb-44 179 6 434(7030):238-­‐243 434(7030):238-­‐243 NUM njb-44 179 7 . . PUNCT njb-44 179 8     SPACE njb-44 179 9 17 17 NUM njb-44 179 10 . . PUNCT njb-44 180 1 levin levin PROPN njb-44 180 2     SPACE njb-44 180 3 se se PROPN njb-44 180 4 , , PUNCT njb-44 180 5     SPACE njb-44 180 6 weiss weiss PROPN njb-44 180 7     SPACE njb-44 180 8 a a DET njb-44 180 9 : : PUNCT njb-44 180 10     SPACE njb-44 180 11 twisting twist VERB njb-44 180 12     SPACE njb-44 180 13 tails tail NOUN njb-44 180 14     SPACE njb-44 180 15 exposed expose VERB njb-44 180 16 : : PUNCT njb-44 180 17     SPACE njb-44 180 18 the the DET njb-44 180 19     SPACE njb-44 180 20 evidence evidence NOUN njb-44 180 21     SPACE njb-44 180 22 for for ADP njb-44 180 23     SPACE njb-44 180 24 tcr tcr PROPN njb-44 180 25     SPACE njb-44 180 26 conformational conformational ADJ njb-44 180 27     SPACE njb-44 180 28 change change NOUN njb-44 180 29 . . PUNCT njb-44 180 30     SPACE njb-44 181 1 j j PROPN njb-44 181 2     SPACE njb-44 181 3 exp exp PROPN njb-44 181 4     SPACE njb-44 181 5 med me VERB njb-44 181 6     SPACE njb-44 181 7 2005 2005 NUM njb-44 181 8 , , PUNCT njb-44 181 9     SPACE njb-44 181 10 201(4):489-­‐492 201(4):489-­‐492 NUM njb-44 181 11 . . PUNCT njb-44 181 12         SPACE njb-44 182 1 18 18 NUM njb-44 182 2 . . PUNCT njb-44 183 1 gil gil PROPN njb-44 183 2     SPACE njb-44 183 3 d d PROPN njb-44 183 4 , , PUNCT njb-44 183 5     SPACE njb-44 183 6 schamel schamel PROPN njb-44 183 7     SPACE njb-44 183 8 ww ww PROPN njb-44 183 9 , , PUNCT njb-44 183 10     SPACE njb-44 183 11 montoya montoya PROPN njb-44 183 12     SPACE njb-44 183 13 m m PROPN njb-44 183 14 , , PUNCT njb-44 183 15     SPACE njb-44 183 16 sanchez-­‐ sanchez-­‐ PROPN njb-44 183 17 madrid madrid PROPN njb-44 183 18     SPACE njb-44 183 19 f f PROPN njb-44 183 20 , , PUNCT njb-44 183 21     SPACE njb-44 183 22 alarcon alarcon PROPN njb-44 183 23     SPACE njb-44 183 24 b b PROPN njb-44 183 25 : : PUNCT njb-44 183 26     SPACE njb-44 183 27 recruitment recruitment NOUN njb-44 183 28     SPACE njb-44 183 29 of of ADP njb-44 183 30     SPACE njb-44 183 31 nck nck ADV njb-44 183 32     SPACE njb-44 183 33 by by ADP njb-44 183 34     SPACE njb-44 183 35 cd3 cd3 PROPN njb-44 183 36     SPACE njb-44 183 37 epsilon epsilon NOUN njb-44 183 38     SPACE njb-44 183 39 reveals reveal VERB njb-44 183 40     SPACE njb-44 183 41 a a DET njb-44 183 42     SPACE njb-44 183 43 ligand-­‐induced ligand-­‐induce VERB njb-44 183 44     SPACE njb-44 183 45 conformational conformational ADJ njb-44 183 46     SPACE njb-44 183 47 change change VERB njb-44 183 48     SPACE njb-44 183 49 essential essential ADJ njb-44 183 50     SPACE njb-44 183 51 for for ADP njb-44 183 52     SPACE njb-44 183 53 t t PROPN njb-44 183 54     SPACE njb-44 183 55 cell cell NOUN njb-44 183 56     SPACE njb-44 183 57 receptor receptor NOUN njb-44 183 58     SPACE njb-44 183 59 signaling signal VERB njb-44 183 60     SPACE njb-44 183 61 and and CCONJ njb-44 183 62     SPACE njb-44 183 63 synapse synapse VERB njb-44 183 64     SPACE njb-44 183 65 formation formation NOUN njb-44 183 66 . . PUNCT njb-44 183 67     SPACE njb-44 184 1 cell cell NOUN njb-44 184 2     SPACE njb-44 184 3 2002 2002 NUM njb-44 184 4 , , PUNCT njb-44 184 5     SPACE njb-44 184 6 109(7):901-­‐912 109(7):901-­‐912 NUM njb-44 184 7 . . PUNCT njb-44 184 8         SPACE njb-44 184 9 19 19 NUM njb-44 184 10 . . PUNCT njb-44 185 1 sun sun PROPN njb-44 185 2     SPACE njb-44 185 3 zy zy PROPN njb-44 185 4 , , PUNCT njb-44 185 5     SPACE njb-44 185 6 kim kim PROPN njb-44 185 7     SPACE njb-44 185 8 st st PROPN njb-44 185 9 , , PUNCT njb-44 185 10     SPACE njb-44 185 11 kim kim PROPN njb-44 185 12     SPACE njb-44 185 13 ic ic PROPN njb-44 185 14 , , PUNCT njb-44 185 15     SPACE njb-44 185 16 fahmy fahmy VERB njb-44 185 17     SPACE njb-44 185 18 a a DET njb-44 185 19 , , PUNCT njb-44 185 20     SPACE njb-44 185 21 reinherz reinherz ADJ njb-44 185 22     SPACE njb-44 185 23 el el PROPN njb-44 185 24 , , PUNCT njb-44 185 25     SPACE njb-44 185 26 wagner wagner VERB njb-44 185 27     SPACE njb-44 185 28 g g NOUN njb-44 185 29 : : PUNCT njb-44 185 30     SPACE njb-44 185 31 solution solution NOUN njb-44 185 32     SPACE njb-44 185 33 structure structure NOUN njb-44 185 34     SPACE njb-44 185 35 of of ADP njb-44 185 36     SPACE njb-44 185 37 the the DET njb-44 185 38     SPACE njb-44 185 39 cd3epsilondelta cd3epsilondelta PROPN njb-44 185 40     SPACE njb-44 185 41 ectodomain ectodomain NOUN njb-44 185 42     SPACE njb-44 185 43 and and CCONJ njb-44 185 44     SPACE njb-44 185 45 comparison comparison NOUN njb-44 185 46     SPACE njb-44 185 47 with with ADP njb-44 185 48     SPACE njb-44 185 49 cd3epsilongamma cd3epsilongamma NOUN njb-44 185 50     SPACE njb-44 185 51 as as ADP njb-44 185 52     SPACE njb-44 185 53 a a DET njb-44 185 54     SPACE njb-44 185 55 basis basis NOUN njb-44 185 56     SPACE njb-44 185 57 for for ADP njb-44 185 58     SPACE njb-44 185 59 modeling model VERB njb-44 185 60     SPACE njb-44 185 61 t t NOUN njb-44 185 62     SPACE njb-44 185 63 cell cell NOUN njb-44 185 64     SPACE njb-44 185 65 receptor receptor NOUN njb-44 185 66     SPACE njb-44 185 67 topology topology NOUN njb-44 185 68     SPACE njb-44 185 69 and and CCONJ njb-44 185 70     SPACE njb-44 185 71 signaling signal VERB njb-44 185 72 . . PUNCT njb-44 185 73     SPACE njb-44 186 1 proc proc PROPN njb-44 186 2     SPACE njb-44 186 3 natl natl PROPN njb-44 186 4     SPACE njb-44 186 5 acad acad PROPN njb-44 186 6     SPACE njb-44 186 7 sci sci PROPN njb-44 186 8     SPACE njb-44 186 9 u u PROPN njb-44 186 10     SPACE njb-44 186 11 s s PART njb-44 186 12     SPACE njb-44 186 13 a a DET njb-44 186 14     SPACE njb-44 186 15 2004 2004 NUM njb-44 186 16 , , PUNCT njb-44 186 17     SPACE njb-44 186 18 101(48):16867-­‐16872 101(48):16867-­‐16872 NUM njb-44 186 19 . . PUNCT njb-44 186 20         SPACE njb-44 187 1 20 20 NUM njb-44 187 2 . . PUNCT njb-44 188 1 arnett arnett PROPN njb-44 188 2     SPACE njb-44 188 3 kl kl PROPN njb-44 188 4 , , PUNCT njb-44 188 5     SPACE njb-44 188 6 harrison harrison PROPN njb-44 188 7     SPACE njb-44 188 8 sc sc PROPN njb-44 188 9 , , PUNCT njb-44 188 10     SPACE njb-44 188 11 wiley wiley PROPN njb-44 188 12     SPACE njb-44 188 13 dc dc PROPN njb-44 188 14 : : PUNCT njb-44 188 15     SPACE njb-44 188 16 crystal crystal NOUN njb-44 188 17     SPACE njb-44 188 18 structure structure NOUN njb-44 188 19     SPACE njb-44 188 20 of of ADP njb-44 188 21     SPACE njb-44 188 22 a a DET njb-44 188 23     SPACE njb-44 188 24 human human NOUN njb-44 188 25     SPACE njb-44 188 26 cd3-­‐epsilon cd3-­‐epsilon NOUN njb-44 188 27 / / SYM njb-44 188 28 delta delta NOUN njb-44 188 29     SPACE njb-44 188 30 dimer dimer NOUN njb-44 188 31     SPACE njb-44 188 32 in in ADP njb-44 188 33     SPACE njb-44 188 34 complex complex NOUN njb-44 188 35     SPACE njb-44 188 36 with with ADP njb-44 188 37     SPACE njb-44 188 38 a a DET njb-44 188 39     SPACE njb-44 188 40 ucht1 ucht1 ADJ njb-44 188 41     SPACE njb-44 188 42 single-­‐chain single-­‐chain ADJ njb-44 188 43     SPACE njb-44 188 44 antibody antibody NOUN njb-44 188 45     SPACE njb-44 188 46 fragment fragment NOUN njb-44 188 47 . . PUNCT njb-44 188 48     SPACE njb-44 189 1 proc proc PROPN njb-44 189 2     SPACE njb-44 189 3 natl natl PROPN njb-44 189 4     SPACE njb-44 189 5 acad acad PROPN njb-44 189 6     SPACE njb-44 189 7 sci sci PROPN njb-44 189 8     SPACE njb-44 189 9 u u PROPN njb-44 189 10     SPACE njb-44 189 11 s s VERB njb-44 189 12     SPACE njb-44 189 13 a a DET njb-44 189 14     SPACE njb-44 189 15 2004 2004 NUM njb-44 189 16 , , PUNCT njb-44 189 17     SPACE njb-44 189 18 101(46):16268-­‐16273 101(46):16268-­‐16273 NUM njb-44 189 19 . . PUNCT njb-44 189 20         SPACE njb-44 190 1 21 21 NUM njb-44 190 2 . . PUNCT njb-44 191 1 sun sun PROPN njb-44 191 2     SPACE njb-44 191 3 zys zys PROPN njb-44 191 4 , , PUNCT njb-44 191 5     SPACE njb-44 191 6 seok seok NOUN njb-44 191 7     SPACE njb-44 191 8 kim kim PROPN njb-44 191 9     SPACE njb-44 191 10 k k PROPN njb-44 191 11 , , PUNCT njb-44 191 12     SPACE njb-44 191 13 wagner wagner VERB njb-44 191 14     SPACE njb-44 191 15 g g NOUN njb-44 191 16 , , PUNCT njb-44 191 17     SPACE njb-44 191 18 reinherz reinherz ADJ njb-44 191 19     SPACE njb-44 191 20 el el PROPN njb-44 191 21 : : PUNCT njb-44 191 22     SPACE njb-44 192 1 mechanisms mechanism NOUN njb-44 192 2     SPACE njb-44 192 3 contributing contribute VERB njb-44 192 4     SPACE njb-44 192 5 to to ADP njb-44 192 6     SPACE njb-44 192 7 t t NOUN njb-44 192 8     SPACE njb-44 192 9 cell cell NOUN njb-44 192 10     SPACE njb-44 192 11 receptor receptor NOUN njb-44 192 12     SPACE njb-44 192 13 signaling signal VERB njb-44 192 14     SPACE njb-44 192 15 and and CCONJ njb-44 192 16     SPACE njb-44 192 17 assembly assembly NOUN njb-44 192 18     SPACE njb-44 192 19 revealed reveal VERB njb-44 192 20     SPACE njb-44 192 21 by by ADP njb-44 192 22     SPACE njb-44 192 23 the the DET njb-44 192 24     SPACE njb-44 192 25 solution solution NOUN njb-44 192 26     SPACE njb-44 192 27 structure structure NOUN njb-44 192 28     SPACE njb-44 192 29 of of ADP njb-44 192 30     SPACE njb-44 192 31 an an DET njb-44 192 32     SPACE njb-44 192 33 ectodomain ectodomain NOUN njb-44 192 34     SPACE njb-44 192 35 fragment fragment NOUN njb-44 192 36     SPACE njb-44 192 37 of of ADP njb-44 192 38     SPACE njb-44 192 39 the the DET njb-44 192 40     SPACE njb-44 192 41 cd3eg cd3eg NOUN njb-44 192 42     SPACE njb-44 192 43 heterodimer heterodimer NOUN njb-44 192 44 . . PUNCT njb-44 192 45     SPACE njb-44 193 1 cell cell NOUN njb-44 193 2     SPACE njb-44 193 3 2001 2001 NUM njb-44 193 4 , , PUNCT njb-44 193 5     SPACE njb-44 193 6 105:913-­‐ 105:913-­‐ NUM njb-44 193 7 923 923 NUM njb-44 193 8 . . PUNCT njb-44 193 9         SPACE njb-44 193 10 22 22 NUM njb-44 193 11 . . PUNCT njb-44 194 1 kjer-­‐nielsen kjer-­‐nielsen PROPN njb-44 194 2     SPACE njb-44 194 3 l l NOUN njb-44 194 4 , , PUNCT njb-44 194 5     SPACE njb-44 194 6 dunstone dunstone PROPN njb-44 194 7     SPACE njb-44 194 8 ma ma PROPN njb-44 194 9 , , PUNCT njb-44 194 10     SPACE njb-44 194 11 kostenko kostenko PROPN njb-44 194 12     SPACE njb-44 194 13 l l PROPN njb-44 194 14 , , PUNCT njb-44 194 15     SPACE njb-44 194 16 ely ely PROPN njb-44 194 17     SPACE njb-44 194 18 lk lk PROPN njb-44 194 19 , , PUNCT njb-44 194 20     SPACE njb-44 194 21 beddoe beddoe PROPN njb-44 194 22     SPACE njb-44 194 23 t t PROPN njb-44 194 24 , , PUNCT njb-44 194 25     SPACE njb-44 194 26 mifsud mifsud PROPN njb-44 194 27     SPACE njb-44 194 28 na na ADP njb-44 194 29 , , PUNCT njb-44 194 30     SPACE njb-44 194 31 purcell purcell NOUN njb-44 194 32     SPACE njb-44 194 33 aw aw INTJ njb-44 194 34 , , PUNCT njb-44 194 35     SPACE njb-44 194 36 brooks brooks PROPN njb-44 194 37     SPACE njb-44 194 38 ag ag PROPN njb-44 194 39 , , PUNCT njb-44 194 40     SPACE njb-44 194 41 mccluskey mccluskey PROPN njb-44 194 42     SPACE njb-44 194 43 j j PROPN njb-44 194 44 , , PUNCT njb-44 194 45     SPACE njb-44 194 46 rossjohn rossjohn PROPN njb-44 194 47     SPACE njb-44 194 48 j j PROPN njb-44 194 49 : : PUNCT njb-44 194 50     SPACE njb-44 194 51 crystal crystal NOUN njb-44 194 52     SPACE njb-44 194 53 structure structure NOUN njb-44 194 54     SPACE njb-44 194 55 of of ADP njb-44 194 56     SPACE njb-44 194 57 the the DET njb-44 194 58     SPACE njb-44 194 59 human human PROPN njb-44 194 60     SPACE njb-44 194 61 t t PROPN njb-44 194 62     SPACE njb-44 194 63 cell cell NOUN njb-44 194 64     SPACE njb-44 194 65 receptor receptor NOUN njb-44 194 66     SPACE njb-44 194 67 cd3 cd3 PROPN njb-44 194 68     SPACE njb-44 194 69 epsilon epsilon NOUN njb-44 194 70     SPACE njb-44 194 71 gamma gamma PROPN njb-44 194 72     SPACE njb-44 194 73 heterodimer heterodimer PROPN njb-44 194 74     SPACE njb-44 194 75 complexed complexe VERB njb-44 194 76     SPACE njb-44 194 77 to to ADP njb-44 194 78     SPACE njb-44 194 79 the the DET njb-44 194 80     SPACE njb-44 194 81 therapeutic therapeutic ADJ njb-44 194 82     SPACE njb-44 194 83 mab mab PROPN njb-44 194 84     SPACE njb-44 194 85 okt3 okt3 PROPN njb-44 194 86 . . PUNCT njb-44 194 87     SPACE njb-44 195 1 proc proc PROPN njb-44 195 2     SPACE njb-44 195 3 natl natl PROPN njb-44 195 4     SPACE njb-44 195 5 acad acad PROPN njb-44 195 6     SPACE njb-44 195 7 sci sci PROPN njb-44 195 8     SPACE njb-44 195 9 u u PROPN njb-44 195 10     SPACE njb-44 195 11 s s VERB njb-44 195 12     SPACE njb-44 195 13 a a DET njb-44 195 14     SPACE njb-44 195 15 2004 2004 NUM njb-44 195 16 , , PUNCT njb-44 195 17     SPACE njb-44 195 18 101(20):7675-­‐7680 101(20):7675-­‐7680 NUM njb-44 195 19 . . PUNCT njb-44 195 20         SPACE njb-44 196 1 23 23 NUM njb-44 196 2 . . PUNCT njb-44 197 1 xu xu PROPN njb-44 197 2     SPACE njb-44 197 3 c c PROPN njb-44 197 4 , , PUNCT njb-44 197 5     SPACE njb-44 197 6 gagnon gagnon PROPN njb-44 197 7     SPACE njb-44 197 8 e e PROPN njb-44 197 9 , , PUNCT njb-44 197 10     SPACE njb-44 197 11 call call VERB njb-44 197 12     SPACE njb-44 197 13 me i PRON njb-44 197 14 , , PUNCT njb-44 197 15     SPACE njb-44 197 16 schnell schnell PROPN njb-44 197 17     SPACE njb-44 197 18 jr jr PROPN njb-44 197 19 , , PUNCT njb-44 197 20     SPACE njb-44 197 21 schwieters schwieter NOUN njb-44 197 22     SPACE njb-44 197 23 cd cd PROPN njb-44 197 24 , , PUNCT njb-44 197 25     SPACE njb-44 197 26 carman carman NOUN njb-44 197 27     SPACE njb-44 197 28 cv cv PROPN njb-44 197 29 , , PUNCT njb-44 197 30     SPACE njb-44 197 31 chou chou PROPN njb-44 197 32     SPACE njb-44 197 33 jj jj PROPN njb-44 197 34 , , PUNCT njb-44 197 35     SPACE njb-44 197 36 wucherpfennig wucherpfennig PROPN njb-44 197 37     SPACE njb-44 197 38 kw kw NOUN njb-44 197 39 : : PUNCT njb-44 197 40     SPACE njb-44 197 41 regulation regulation NOUN njb-44 197 42     SPACE njb-44 197 43 of of ADP njb-44 197 44     SPACE njb-44 197 45 t t PROPN njb-44 197 46     SPACE njb-44 197 47 cell cell NOUN njb-44 197 48     SPACE njb-44 197 49 receptor receptor NOUN njb-44 197 50     SPACE njb-44 197 51 activation activation NOUN njb-44 197 52     SPACE njb-44 197 53 by by ADP njb-44 197 54     SPACE njb-44 197 55 dynamic dynamic ADJ njb-44 197 56     SPACE njb-44 197 57 membrane membrane NOUN njb-44 197 58     SPACE njb-44 197 59 binding binding NOUN njb-44 197 60     SPACE njb-44 197 61 of of ADP njb-44 197 62     SPACE njb-44 197 63 the the DET njb-44 197 64     SPACE njb-44 197 65 cd3epsilon cd3epsilon PROPN njb-44 197 66     SPACE njb-44 197 67 cytoplasmic cytoplasmic ADJ njb-44 197 68     SPACE njb-44 197 69 tyrosine-­‐based tyrosine-­‐base VERB njb-44 197 70     SPACE njb-44 197 71 motif motif NOUN njb-44 197 72 . . PUNCT njb-44 197 73     SPACE njb-44 198 1 cell cell NOUN njb-44 198 2     SPACE njb-44 198 3 2008 2008 NUM njb-44 198 4 , , PUNCT njb-44 198 5     SPACE njb-44 198 6 135(4):702-­‐713 135(4):702-­‐713 NUM njb-44 198 7 . . PUNCT njb-44 198 8         SPACE njb-44 198 9 24 24 NUM njb-44 198 10 . . PUNCT njb-44 199 1 deford-­‐watts deford-­‐watt NOUN njb-44 199 2     SPACE njb-44 199 3 lm lm PROPN njb-44 199 4 , , PUNCT njb-44 199 5     SPACE njb-44 199 6 tassin tassin NOUN njb-44 199 7     SPACE njb-44 199 8 tc tc NOUN njb-44 199 9 , , PUNCT njb-44 199 10     SPACE njb-44 199 11 becker becker PROPN njb-44 199 12     SPACE njb-44 199 13 am be AUX njb-44 199 14 , , PUNCT njb-44 199 15     SPACE njb-44 199 16 medeiros medeiros PROPN njb-44 199 17     SPACE njb-44 199 18 jj jj PROPN njb-44 199 19 , , PUNCT njb-44 199 20     SPACE njb-44 199 21 albanesi albanesi VERB njb-44 199 22     SPACE njb-44 199 23 jp jp NOUN njb-44 199 24 , , PUNCT njb-44 199 25     SPACE njb-44 199 26 love love VERB njb-44 199 27     SPACE njb-44 199 28 pe pe PROPN njb-44 199 29 , , PUNCT njb-44 199 30     SPACE njb-44 199 31 wulfing wulfe VERB njb-44 199 32     SPACE njb-44 199 33 c c NOUN njb-44 199 34 , , PUNCT njb-44 199 35     SPACE njb-44 199 36 van van NOUN njb-44 199 37     SPACE njb-44 199 38 oers oer NOUN njb-44 199 39     SPACE njb-44 199 40 ns ns ADP njb-44 199 41 : : PUNCT njb-44 199 42     SPACE njb-44 199 43 the the DET njb-44 199 44     SPACE njb-44 199 45 cytoplasmic cytoplasmic ADJ njb-44 199 46     SPACE njb-44 199 47 tail tail NOUN njb-44 199 48     SPACE njb-44 199 49 of of ADP njb-44 199 50     SPACE njb-44 199 51 the the DET njb-44 199 52     SPACE njb-44 199 53 t t PROPN njb-44 199 54     SPACE njb-44 199 55 cell cell NOUN njb-44 199 56     SPACE njb-44 199 57 receptor receptor NOUN njb-44 199 58     SPACE njb-44 199 59 cd3 cd3 PROPN njb-44 199 60     SPACE njb-44 199 61 epsilon epsilon NOUN njb-44 199 62     SPACE njb-44 199 63 subunit subunit NOUN njb-44 199 64     SPACE njb-44 199 65 contains contain VERB njb-44 199 66     SPACE njb-44 199 67 a a DET njb-44 199 68     SPACE njb-44 199 69 phospholipid-­‐binding phospholipid-­‐binde VERB njb-44 199 70     SPACE njb-44 199 71 motif motif NOUN njb-44 199 72     SPACE njb-44 199 73 that that PRON njb-44 199 74     SPACE njb-44 199 75 regulates regulate VERB njb-44 199 76     SPACE njb-44 199 77 t t NOUN njb-44 199 78     SPACE njb-44 199 79 cell cell NOUN njb-44 199 80     SPACE njb-44 199 81 functions function NOUN njb-44 199 82 . . PUNCT njb-44 199 83     SPACE njb-44 200 1 j j PROPN njb-44 200 2     SPACE njb-44 200 3 immunol immunol NOUN njb-44 200 4     SPACE njb-44 200 5 2009 2009 NUM njb-44 200 6 , , PUNCT njb-44 200 7     SPACE njb-44 200 8 183(2):1055-­‐ 183(2):1055-­‐ NUM njb-44 200 9 1064 1064 NUM njb-44 200 10 . . PUNCT njb-44 200 11         SPACE njb-44 200 12 nepal nepal ADJ njb-44 200 13     SPACE njb-44 200 14 journal journal NOUN njb-44 200 15     SPACE njb-44 200 16 of of ADP njb-44 200 17     SPACE njb-44 200 18 biotechnology biotechnology NOUN njb-44 200 19 . . PUNCT njb-44 200 20         SPACE njb-44 201 1 jan jan PROPN njb-44 201 2     SPACE njb-44 201 3 2012 2012 NUM njb-44 201 4 , , PUNCT njb-44 201 5     SPACE njb-44 201 6 vol vol NOUN njb-44 201 7 . . PUNCT njb-44 201 8     SPACE njb-44 202 1 2 2 NUM njb-44 202 2 , , PUNCT njb-44 202 3     SPACE njb-44 202 4 no no INTJ njb-44 202 5 . . PUNCT njb-44 202 6     SPACE njb-44 203 1 1 1 NUM njb-44 203 2 : : PUNCT njb-44 203 3     SPACE njb-44 203 4 62 62 NUM njb-44 203 5     SPACE njb-44 203 6 – – PUNCT njb-44 203 7     SPACE njb-44 203 8 71 71 NUM njb-44 203 9                                                                                                                                                                                                                                         SPACE njb-44 203 10 biotechnology biotechnology NOUN njb-44 203 11     SPACE njb-44 203 12 society society NOUN njb-44 203 13     SPACE njb-44 203 14 of of ADP njb-44 203 15     SPACE njb-44 203 16 nepal nepal NOUN njb-44 203 17     SPACE njb-44 203 18 ( ( PUNCT njb-44 203 19 bsn bsn PROPN njb-44 203 20 ) ) PUNCT njb-44 203 21 , , PUNCT njb-44 203 22     SPACE njb-44 203 23 all all DET njb-44 203 24     SPACE njb-44 203 25 rights right NOUN njb-44 203 26     SPACE njb-44 203 27 reserved reserve VERB njb-44 203 28     SPACE njb-44 203 29 71 71 NUM njb-44 203 30 25 25 NUM njb-44 203 31 . . PUNCT njb-44 204 1 aivazian aivazian PROPN njb-44 204 2     SPACE njb-44 204 3 d d PROPN njb-44 204 4 , , PUNCT njb-44 204 5     SPACE njb-44 204 6 stern stern ADJ njb-44 204 7     SPACE njb-44 204 8 lj lj PROPN njb-44 204 9 : : PUNCT njb-44 204 10     SPACE njb-44 204 11 phosphorylation phosphorylation NOUN njb-44 204 12     SPACE njb-44 204 13 of of ADP njb-44 204 14     SPACE njb-44 204 15 t t PROPN njb-44 204 16     SPACE njb-44 204 17 cell cell NOUN njb-44 204 18     SPACE njb-44 204 19 receptor receptor NOUN njb-44 204 20     SPACE njb-44 204 21 zeta zeta NOUN njb-44 204 22     SPACE njb-44 204 23 is be AUX njb-44 204 24     SPACE njb-44 204 25 regulated regulate VERB njb-44 204 26     SPACE njb-44 204 27 by by ADP njb-44 204 28     SPACE njb-44 204 29 a a DET njb-44 204 30     SPACE njb-44 204 31 lipid lipid NOUN njb-44 204 32     SPACE njb-44 204 33 dependent dependent ADJ njb-44 204 34     SPACE njb-44 204 35 folding fold VERB njb-44 204 36     SPACE njb-44 204 37 transition transition NOUN njb-44 204 38 . . PUNCT njb-44 204 39     SPACE njb-44 205 1 nat nat PROPN njb-44 205 2     SPACE njb-44 205 3 struct struct VERB njb-44 205 4     SPACE njb-44 205 5 biol biol NOUN njb-44 205 6     SPACE njb-44 205 7 2000 2000 NUM njb-44 205 8 , , PUNCT njb-44 205 9     SPACE njb-44 205 10 7(11):1023-­‐1026 7(11):1023-­‐1026 NUM njb-44 205 11 . . PUNCT njb-44 205 12         SPACE njb-44 205 13 26 26 NUM njb-44 205 14 . . PUNCT njb-44 206 1 ma ma PROPN njb-44 206 2     SPACE njb-44 206 3 z z PROPN njb-44 206 4 , , PUNCT njb-44 206 5     SPACE njb-44 206 6 sharp sharp ADJ njb-44 206 7     SPACE njb-44 206 8 ka ka PROPN njb-44 206 9 , , PUNCT njb-44 206 10     SPACE njb-44 206 11 janmey janmey PROPN njb-44 206 12     SPACE njb-44 206 13 pa pa PROPN njb-44 206 14 , , PUNCT njb-44 206 15     SPACE njb-44 206 16 finkel finkel PROPN njb-44 206 17     SPACE njb-44 206 18 th th PROPN njb-44 206 19 : : PUNCT njb-44 206 20     SPACE njb-44 206 21 surface-­‐ surface-­‐ VERB njb-44 206 22 anchored anchor VERB njb-44 206 23     SPACE njb-44 206 24 monomeric monomeric ADJ njb-44 206 25     SPACE njb-44 206 26 agonist agonist NOUN njb-44 206 27     SPACE njb-44 206 28 pmhcs pmhc NOUN njb-44 206 29     SPACE njb-44 206 30 alone alone ADV njb-44 206 31     SPACE njb-44 206 32 trigger trigger NOUN njb-44 206 33     SPACE njb-44 206 34 tcr tcr PROPN njb-44 206 35     SPACE njb-44 206 36 with with ADP njb-44 206 37     SPACE njb-44 206 38 high high ADJ njb-44 206 39     SPACE njb-44 206 40 sensitivity sensitivity NOUN njb-44 206 41 . . PUNCT njb-44 206 42     SPACE njb-44 207 1 plos plos PROPN njb-44 207 2     SPACE njb-44 207 3 biol biol PROPN njb-44 207 4     SPACE njb-44 207 5 2008 2008 NUM njb-44 207 6 , , PUNCT njb-44 207 7     SPACE njb-44 207 8 6(2):e43 6(2):e43 NUM njb-44 207 9 . . PUNCT njb-44 207 10     SPACE njb-44 207 11 27 27 NUM njb-44 207 12 . . PUNCT njb-44 208 1 ma ma PROPN njb-44 208 2     SPACE njb-44 208 3 z z PROPN njb-44 208 4 , , PUNCT njb-44 208 5     SPACE njb-44 208 6 janmey janmey PROPN njb-44 208 7     SPACE njb-44 208 8 pa pa PROPN njb-44 208 9 , , PUNCT njb-44 208 10     SPACE njb-44 208 11 finkel finkel PROPN njb-44 208 12     SPACE njb-44 208 13 th th PROPN njb-44 208 14 : : PUNCT njb-44 208 15     SPACE njb-44 208 16 the the DET njb-44 208 17     SPACE njb-44 208 18 receptor receptor NOUN njb-44 208 19     SPACE njb-44 208 20 deformation deformation NOUN njb-44 208 21     SPACE njb-44 208 22 model model NOUN njb-44 208 23     SPACE njb-44 208 24 of of ADP njb-44 208 25     SPACE njb-44 208 26 tcr tcr PROPN njb-44 208 27     SPACE njb-44 208 28 triggering trigger VERB njb-44 208 29 . . PUNCT njb-44 208 30     SPACE njb-44 209 1 faseb faseb NOUN njb-44 209 2     SPACE njb-44 209 3 j j PROPN njb-44 209 4     SPACE njb-44 209 5 2008 2008 NUM njb-44 209 6 , , PUNCT njb-44 209 7     SPACE njb-44 209 8 22(4):1002-­‐1008 22(4):1002-­‐1008 NUM njb-44 209 9 . . PUNCT njb-44 209 10         SPACE njb-44 209 11 28 28 NUM njb-44 209 12 . . PUNCT njb-44 210 1 stone stone NOUN njb-44 210 2     SPACE njb-44 210 3 jd jd PROPN njb-44 210 4 , , PUNCT njb-44 210 5     SPACE njb-44 210 6 stern stern ADJ njb-44 210 7     SPACE njb-44 210 8 lj lj PROPN njb-44 210 9 : : PUNCT njb-44 210 10     SPACE njb-44 210 11 cd8 cd8 PROPN njb-44 210 12     SPACE njb-44 210 13 t t PROPN njb-44 210 14     SPACE njb-44 210 15 cells cell NOUN njb-44 210 16 , , PUNCT njb-44 210 17     SPACE njb-44 210 18 like like ADP njb-44 210 19     SPACE njb-44 210 20 cd4 cd4 X njb-44 210 21     SPACE njb-44 210 22 t t NOUN njb-44 210 23     SPACE njb-44 210 24 cells cell NOUN njb-44 210 25 , , PUNCT njb-44 210 26     SPACE njb-44 210 27 are be AUX njb-44 210 28     SPACE njb-44 210 29 triggered trigger VERB njb-44 210 30     SPACE njb-44 210 31 by by ADP njb-44 210 32     SPACE njb-44 210 33 multivalent multivalent ADJ njb-44 210 34     SPACE njb-44 210 35 engagement engagement NOUN njb-44 210 36     SPACE njb-44 210 37 of of ADP njb-44 210 38     SPACE njb-44 210 39 tcrs tcrs NOUN njb-44 210 40     SPACE njb-44 210 41 by by ADP njb-44 210 42     SPACE njb-44 210 43 mhc-­‐peptide mhc-­‐peptide NOUN njb-44 210 44     SPACE njb-44 210 45 ligands ligand NOUN njb-44 210 46     SPACE njb-44 210 47 but but CCONJ njb-44 210 48     SPACE njb-44 210 49 not not PART njb-44 210 50     SPACE njb-44 210 51 by by ADP njb-44 210 52     SPACE njb-44 210 53 monovalent monovalent NOUN njb-44 210 54     SPACE njb-44 210 55 engagement engagement NOUN njb-44 210 56 . . PUNCT njb-44 210 57     SPACE njb-44 211 1 j j PROPN njb-44 211 2     SPACE njb-44 211 3 immunol immunol NOUN njb-44 211 4     SPACE njb-44 211 5 2006 2006 NUM njb-44 211 6 , , PUNCT njb-44 211 7     SPACE njb-44 211 8 176(3):1498-­‐1505 176(3):1498-­‐1505 NUM njb-44 211 9 . . PUNCT njb-44 211 10         SPACE njb-44 211 11 29 29 NUM njb-44 211 12 . . PUNCT njb-44 212 1 cochran cochran PROPN njb-44 212 2     SPACE njb-44 212 3 jr jr PROPN njb-44 212 4 , , PUNCT njb-44 212 5     SPACE njb-44 212 6 cameron cameron PROPN njb-44 212 7     SPACE njb-44 212 8 to to ADP njb-44 212 9 , , PUNCT njb-44 212 10     SPACE njb-44 212 11 stern stern ADJ njb-44 212 12     SPACE njb-44 212 13 lj lj PROPN njb-44 212 14 : : PUNCT njb-44 212 15     SPACE njb-44 212 16 the the DET njb-44 212 17     SPACE njb-44 212 18 relationship relationship NOUN njb-44 212 19     SPACE njb-44 212 20 of of ADP njb-44 212 21     SPACE njb-44 212 22 mhc-­‐peptide mhc-­‐peptide NOUN njb-44 212 23     SPACE njb-44 212 24 binding bind VERB njb-44 212 25     SPACE njb-44 212 26 and and CCONJ njb-44 212 27     SPACE njb-44 212 28 t t PROPN njb-44 212 29     SPACE njb-44 212 30 cell cell NOUN njb-44 212 31     SPACE njb-44 212 32 activation activation NOUN njb-44 212 33     SPACE njb-44 212 34 probed probed NOUN njb-44 212 35     SPACE njb-44 212 36 using use VERB njb-44 212 37     SPACE njb-44 212 38 chemically chemically ADV njb-44 212 39     SPACE njb-44 212 40 defined define VERB njb-44 212 41     SPACE njb-44 212 42 mhc mhc ADP njb-44 212 43     SPACE njb-44 212 44 class class NOUN njb-44 212 45     SPACE njb-44 212 46 ii ii PROPN njb-44 212 47     SPACE njb-44 212 48 oligomers oligomer NOUN njb-44 212 49 . . PUNCT njb-44 212 50     SPACE njb-44 213 1 immunity immunity NOUN njb-44 213 2     SPACE njb-44 213 3 2000 2000 NUM njb-44 213 4 , , PUNCT njb-44 213 5     SPACE njb-44 213 6 12(3):241-­‐250 12(3):241-­‐250 NUM njb-44 213 7 . . PUNCT njb-44 213 8         SPACE njb-44 213 9 30 30 NUM njb-44 213 10 . . PUNCT njb-44 214 1 minguet minguet PROPN njb-44 214 2     SPACE njb-44 214 3 s s PROPN njb-44 214 4 , , PUNCT njb-44 214 5     SPACE njb-44 214 6 schamel schamel PROPN njb-44 214 7     SPACE njb-44 214 8 wwa wwa PROPN njb-44 214 9 : : PUNCT njb-44 214 10     SPACE njb-44 214 11 a a DET njb-44 214 12     SPACE njb-44 214 13 permissive permissive ADJ njb-44 214 14     SPACE njb-44 214 15 geometry geometry NOUN njb-44 214 16     SPACE njb-44 214 17 model model NOUN njb-44 214 18     SPACE njb-44 214 19 for for ADP njb-44 214 20     SPACE njb-44 214 21 tcr-­‐cd3 tcr-­‐cd3 PROPN njb-44 214 22     SPACE njb-44 214 23 activation activation NOUN njb-44 214 24 . . PUNCT njb-44 214 25     SPACE njb-44 215 1 trends trend NOUN njb-44 215 2     SPACE njb-44 215 3 biochem biochem NOUN njb-44 215 4     SPACE njb-44 215 5 sci sci PROPN njb-44 215 6     SPACE njb-44 215 7 2008 2008 NUM njb-44 215 8 , , PUNCT njb-44 215 9     SPACE njb-44 215 10 33(2):51-­‐57 33(2):51-­‐57 NUM njb-44 215 11 . . PUNCT njb-44 215 12         SPACE njb-44 216 1 31 31 NUM njb-44 216 2 . . PUNCT njb-44 217 1 secrist secrist PROPN njb-44 217 2     SPACE njb-44 217 3 jp jp PROPN njb-44 217 4 , , PUNCT njb-44 217 5     SPACE njb-44 217 6 burns burn VERB njb-44 217 7     SPACE njb-44 217 8 la la PROPN njb-44 217 9 , , PUNCT njb-44 217 10     SPACE njb-44 217 11 karnitz karnitz PROPN njb-44 217 12     SPACE njb-44 217 13 l l PROPN njb-44 217 14 , , PUNCT njb-44 217 15     SPACE njb-44 217 16 koretzky koretzky PROPN njb-44 217 17     SPACE njb-44 217 18 ga ga PROPN njb-44 217 19 , , PUNCT njb-44 217 20     SPACE njb-44 217 21 abraham abraham PROPN njb-44 217 22     SPACE njb-44 217 23 rt rt PROPN njb-44 217 24 : : PUNCT njb-44 217 25     SPACE njb-44 217 26 stimulatory stimulatory ADJ njb-44 217 27     SPACE njb-44 217 28 effects effect NOUN njb-44 217 29     SPACE njb-44 217 30 of of ADP njb-44 217 31     SPACE njb-44 217 32 the the DET njb-44 217 33     SPACE njb-44 217 34 protein protein NOUN njb-44 217 35     SPACE njb-44 217 36 tyrosine tyrosine NOUN njb-44 217 37     SPACE njb-44 217 38 phosphatase phosphatase NOUN njb-44 217 39     SPACE njb-44 217 40 inhibitor inhibitor NOUN njb-44 217 41 , , PUNCT njb-44 217 42     SPACE njb-44 217 43 pervanadate pervanadate NOUN njb-44 217 44 , , PUNCT njb-44 217 45     SPACE njb-44 217 46 on on ADP njb-44 217 47     SPACE njb-44 217 48 t-­‐cell t-­‐cell PROPN njb-44 217 49     SPACE njb-44 217 50 activation activation NOUN njb-44 217 51     SPACE njb-44 217 52 events event NOUN njb-44 217 53 . . PUNCT njb-44 217 54     SPACE njb-44 218 1 j j X njb-44 218 2     SPACE njb-44 218 3 biol biol ADJ njb-44 218 4     SPACE njb-44 218 5 chem chem NOUN njb-44 218 6     SPACE njb-44 218 7 1993 1993 NUM njb-44 218 8 , , PUNCT njb-44 218 9     SPACE njb-44 218 10 268(8):5886-­‐5893 268(8):5886-­‐5893 NUM njb-44 218 11 . . PUNCT njb-44 218 12         SPACE njb-44 218 13 32 32 NUM njb-44 218 14 . . PUNCT njb-44 219 1 choudhuri choudhuri PROPN njb-44 219 2     SPACE njb-44 219 3 k k PROPN njb-44 219 4 , , PUNCT njb-44 219 5     SPACE njb-44 219 6 wiseman wiseman PROPN njb-44 219 7     SPACE njb-44 219 8 d d PROPN njb-44 219 9 , , PUNCT njb-44 219 10     SPACE njb-44 219 11 brown brown PROPN njb-44 219 12     SPACE njb-44 219 13 mh mh PROPN njb-44 219 14 , , PUNCT njb-44 219 15     SPACE njb-44 219 16 gould gould AUX njb-44 219 17     SPACE njb-44 219 18 k k INTJ njb-44 219 19 , , PUNCT njb-44 219 20     SPACE njb-44 219 21 van van NOUN njb-44 219 22     SPACE njb-44 219 23 der der PROPN njb-44 219 24     SPACE njb-44 219 25 merwe merwe PROPN njb-44 219 26     SPACE njb-44 219 27 pa pa PROPN njb-44 219 28 : : PUNCT njb-44 219 29     SPACE njb-44 219 30 t-­‐cell t-­‐cell PROPN njb-44 219 31     SPACE njb-44 219 32 receptor receptor NOUN njb-44 219 33     SPACE njb-44 219 34 triggering trigger VERB njb-44 219 35     SPACE njb-44 219 36 is be AUX njb-44 219 37     SPACE njb-44 219 38 critically critically ADV njb-44 219 39     SPACE njb-44 219 40 dependent dependent ADJ njb-44 219 41     SPACE njb-44 219 42 on on ADP njb-44 219 43     SPACE njb-44 219 44 the the DET njb-44 219 45     SPACE njb-44 219 46 dimensions dimension NOUN njb-44 219 47     SPACE njb-44 219 48 of of ADP njb-44 219 49     SPACE njb-44 219 50 its its PRON njb-44 219 51     SPACE njb-44 219 52 peptide-­‐mhc peptide-­‐mhc NOUN njb-44 219 53     SPACE njb-44 219 54 ligand ligand NOUN njb-44 219 55 . . PUNCT njb-44 219 56     SPACE njb-44 220 1 nature nature NOUN njb-44 220 2     SPACE njb-44 220 3 2005 2005 NUM njb-44 220 4 , , PUNCT njb-44 220 5     SPACE njb-44 220 6 436(7050):578-­‐582 436(7050):578-­‐582 NUM njb-44 220 7 . . PUNCT njb-44 220 8         SPACE njb-44 220 9 33 33 NUM njb-44 220 10 . . PUNCT njb-44 221 1 davis davis PROPN njb-44 221 2     SPACE njb-44 221 3 sj sj PROPN njb-44 221 4 , , PUNCT njb-44 221 5     SPACE njb-44 221 6 van van NOUN njb-44 221 7     SPACE njb-44 221 8 der der PROPN njb-44 221 9     SPACE njb-44 221 10 merwe merwe PROPN njb-44 221 11     SPACE njb-44 221 12 pa pa PROPN njb-44 221 13 : : PUNCT njb-44 221 14     SPACE njb-44 221 15 the the DET njb-44 221 16     SPACE njb-44 221 17 kinetic-­‐ kinetic-­‐ PROPN njb-44 221 18 segregation segregation NOUN njb-44 221 19     SPACE njb-44 221 20 model model NOUN njb-44 221 21 : : PUNCT njb-44 221 22     SPACE njb-44 222 1 tcr tcr PROPN njb-44 222 2     SPACE njb-44 222 3 triggering trigger VERB njb-44 222 4     SPACE njb-44 222 5 and and CCONJ njb-44 222 6     SPACE njb-44 222 7 beyond beyond ADP njb-44 222 8 . . PUNCT njb-44 222 9     SPACE njb-44 223 1 nat nat PROPN njb-44 223 2     SPACE njb-44 223 3 immunol immunol NOUN njb-44 223 4     SPACE njb-44 223 5 2006 2006 NUM njb-44 223 6 , , PUNCT njb-44 223 7     SPACE njb-44 223 8 7(8):803-­‐809 7(8):803-­‐809 NUM njb-44 223 9 . . PUNCT njb-44 223 10         SPACE njb-44 224 1 34 34 NUM njb-44 224 2 . . PUNCT njb-44 224 3 boniface boniface PROPN njb-44 224 4     SPACE njb-44 224 5 jj jj PROPN njb-44 224 6 , , PUNCT njb-44 224 7     SPACE njb-44 224 8 rabinowitz rabinowitz PROPN njb-44 224 9     SPACE njb-44 224 10 jd jd PROPN njb-44 224 11 , , PUNCT njb-44 224 12     SPACE njb-44 224 13 wulfing wulfe VERB njb-44 224 14     SPACE njb-44 224 15 c c PROPN njb-44 224 16 , , PUNCT njb-44 224 17     SPACE njb-44 224 18 hampl hampl NOUN njb-44 224 19     SPACE njb-44 224 20 j j PROPN njb-44 224 21 , , PUNCT njb-44 224 22     SPACE njb-44 224 23 reich reich PROPN njb-44 224 24     SPACE njb-44 224 25 z z PROPN njb-44 224 26 , , PUNCT njb-44 224 27     SPACE njb-44 224 28 altman altman PROPN njb-44 224 29     SPACE njb-44 224 30 jd jd PROPN njb-44 224 31 , , PUNCT njb-44 224 32     SPACE njb-44 224 33 kantor kantor NOUN njb-44 224 34     SPACE njb-44 224 35 rm rm PROPN njb-44 224 36 , , PUNCT njb-44 224 37     SPACE njb-44 224 38 beeson beeson PROPN njb-44 224 39     SPACE njb-44 224 40 c c PROPN njb-44 224 41 , , PUNCT njb-44 224 42     SPACE njb-44 224 43 mcconnell mcconnell NOUN njb-44 224 44     SPACE njb-44 224 45 hm hm INTJ njb-44 224 46 , , PUNCT njb-44 224 47     SPACE njb-44 224 48 davis davis PROPN njb-44 224 49     SPACE njb-44 224 50 mm mm PROPN njb-44 224 51 : : PUNCT njb-44 224 52     SPACE njb-44 224 53 initiation initiation NOUN njb-44 224 54     SPACE njb-44 224 55 of of ADP njb-44 224 56     SPACE njb-44 224 57 signal signal NOUN njb-44 224 58     SPACE njb-44 224 59 transduction transduction NOUN njb-44 224 60     SPACE njb-44 224 61 through through ADP njb-44 224 62     SPACE njb-44 224 63 the the DET njb-44 224 64     SPACE njb-44 224 65 t t PROPN njb-44 224 66     SPACE njb-44 224 67 cell cell NOUN njb-44 224 68     SPACE njb-44 224 69 receptor receptor NOUN njb-44 224 70     SPACE njb-44 224 71 requires require VERB njb-44 224 72     SPACE njb-44 224 73 the the DET njb-44 224 74     SPACE njb-44 224 75 multivalent multivalent ADJ njb-44 224 76     SPACE njb-44 224 77 engagement engagement NOUN njb-44 224 78     SPACE njb-44 224 79 of of ADP njb-44 224 80     SPACE njb-44 224 81 peptide peptide NOUN njb-44 224 82 / / SYM njb-44 224 83 mhc mhc NOUN njb-44 224 84     SPACE njb-44 224 85 ligands ligand NOUN njb-44 224 86     SPACE njb-44 225 1 [ [ PUNCT njb-44 225 2 corrected correct VERB njb-44 225 3 ] ] PUNCT njb-44 225 4 . . PUNCT njb-44 225 5     SPACE njb-44 226 1 immunity immunity NOUN njb-44 226 2     SPACE njb-44 226 3 1998 1998 NUM njb-44 226 4 , , PUNCT njb-44 226 5     SPACE njb-44 226 6 9(4):459-­‐466 9(4):459-­‐466 NUM njb-44 226 7 . . PUNCT njb-44 226 8         SPACE njb-44 226 9 35 35 NUM njb-44 226 10 . . PUNCT njb-44 227 1 horejsi horejsi PROPN njb-44 227 2     SPACE njb-44 227 3 v v NOUN njb-44 227 4 : : PUNCT njb-44 227 5     SPACE njb-44 227 6 lipid lipid NOUN njb-44 227 7     SPACE njb-44 227 8 rafts raft NOUN njb-44 227 9     SPACE njb-44 227 10 and and CCONJ njb-44 227 11     SPACE njb-44 227 12 their their PRON njb-44 227 13     SPACE njb-44 227 14 roles role NOUN njb-44 227 15     SPACE njb-44 227 16 in in ADP njb-44 227 17     SPACE njb-44 227 18 t-­‐cell t-­‐cell PROPN njb-44 227 19     SPACE njb-44 227 20 activation activation NOUN njb-44 227 21 . . PUNCT njb-44 227 22     SPACE njb-44 228 1 microbes microbe NOUN njb-44 228 2     SPACE njb-44 228 3 infect infect VERB njb-44 228 4     SPACE njb-44 228 5 2005 2005 NUM njb-44 228 6 , , PUNCT njb-44 228 7     SPACE njb-44 228 8 7(2):310-­‐316 7(2):310-­‐316 NUM njb-44 228 9 . . PUNCT njb-44 228 10         SPACE njb-44 228 11 36 36 NUM njb-44 228 12 . . PUNCT njb-44 229 1 horejsi horejsi PROPN njb-44 229 2     SPACE njb-44 229 3 v v NOUN njb-44 229 4 : : PUNCT njb-44 229 5     SPACE njb-44 229 6 the the DET njb-44 229 7     SPACE njb-44 229 8 roles role NOUN njb-44 229 9     SPACE njb-44 229 10 of of ADP njb-44 229 11     SPACE njb-44 229 12 membrane membrane NOUN njb-44 229 13     SPACE njb-44 229 14 microdomains microdomain NOUN njb-44 229 15     SPACE njb-44 229 16 ( ( PUNCT njb-44 229 17 rafts raft NOUN njb-44 229 18 ) ) PUNCT njb-44 229 19     SPACE njb-44 229 20 in in ADP njb-44 229 21     SPACE njb-44 229 22 t t NOUN njb-44 229 23     SPACE njb-44 229 24 cell cell NOUN njb-44 229 25     SPACE njb-44 229 26 activation activation NOUN njb-44 229 27 . . PUNCT njb-44 229 28     SPACE njb-44 230 1 immunol immunol NOUN njb-44 230 2     SPACE njb-44 230 3 rev rev PROPN njb-44 230 4     SPACE njb-44 230 5 2003 2003 NUM njb-44 230 6 , , PUNCT njb-44 230 7     SPACE njb-44 230 8 191:148-­‐164 191:148-­‐164 NUM njb-44 230 9 . . PUNCT njb-44 230 10         SPACE njb-44 231 1 37 37 NUM njb-44 231 2 . . PUNCT njb-44 232 1 su su PROPN njb-44 232 2     SPACE njb-44 232 3 mw mw PROPN njb-44 232 4 , , PUNCT njb-44 232 5     SPACE njb-44 232 6 yu yu PROPN njb-44 232 7     SPACE njb-44 232 8 cl cl PROPN njb-44 232 9 , , PUNCT njb-44 232 10     SPACE njb-44 232 11 burakoff burakoff PROPN njb-44 232 12     SPACE njb-44 232 13 sj sj PROPN njb-44 232 14 , , PUNCT njb-44 232 15     SPACE njb-44 232 16 jin jin NOUN njb-44 232 17     SPACE njb-44 232 18 yj yj PROPN njb-44 232 19 : : PUNCT njb-44 232 20     SPACE njb-44 232 21 targeting target VERB njb-44 232 22     SPACE njb-44 232 23 src src NOUN njb-44 232 24     SPACE njb-44 232 25 homology homology NOUN njb-44 232 26     SPACE njb-44 232 27 2 2 NUM njb-44 232 28     SPACE njb-44 232 29 domain-­‐containing domain-­‐containe VERB njb-44 232 30     SPACE njb-44 232 31 tyrosine tyrosine NOUN njb-44 232 32     SPACE njb-44 232 33 phosphatase phosphatase NOUN njb-44 232 34     SPACE njb-44 232 35 ( ( PUNCT njb-44 232 36 shp-­‐1 shp-­‐1 ADJ njb-44 232 37 ) ) PUNCT njb-44 232 38     SPACE njb-44 232 39 into into ADP njb-44 232 40     SPACE njb-44 232 41 lipid lipid NOUN njb-44 232 42     SPACE njb-44 232 43 rafts raft NOUN njb-44 232 44     SPACE njb-44 232 45 inhibits inhibit NOUN njb-44 232 46     SPACE njb-44 232 47 cd3-­‐induced cd3-­‐induce VERB njb-44 232 48     SPACE njb-44 232 49 t t PROPN njb-44 232 50     SPACE njb-44 232 51 cell cell NOUN njb-44 232 52     SPACE njb-44 232 53 activation activation NOUN njb-44 232 54 . . PUNCT njb-44 232 55     SPACE njb-44 232 56 journal journal PROPN njb-44 232 57     SPACE njb-44 232 58 of of ADP njb-44 232 59     SPACE njb-44 232 60 immunology immunology NOUN njb-44 232 61     SPACE njb-44 232 62 2001 2001 NUM njb-44 232 63 , , PUNCT njb-44 232 64     SPACE njb-44 232 65 166(6):3975-­‐3982 166(6):3975-­‐3982 NUM njb-44 232 66 . . PUNCT njb-44 232 67         SPACE njb-44 232 68 38 38 NUM njb-44 232 69 . . PUNCT njb-44 233 1 he he PRON njb-44 233 2     SPACE njb-44 233 3 x x PROPN njb-44 233 4 , , PUNCT njb-44 233 5     SPACE njb-44 233 6 woodford-­‐thomas woodford-­‐thomas X njb-44 233 7     SPACE njb-44 233 8 ta ta AUX njb-44 233 9 , , PUNCT njb-44 233 10     SPACE njb-44 233 11 johnson johnson PROPN njb-44 233 12     SPACE njb-44 233 13 kg kg PROPN njb-44 233 14 , , PUNCT njb-44 233 15     SPACE njb-44 233 16 shah shah VERB njb-44 233 17     SPACE njb-44 233 18 dd dd PROPN njb-44 233 19 , , PUNCT njb-44 233 20     SPACE njb-44 233 21 thomas thomas PROPN njb-44 233 22     SPACE njb-44 233 23 ml ml PROPN njb-44 233 24 : : PUNCT njb-44 233 25     SPACE njb-44 233 26 targeting target VERB njb-44 233 27     SPACE njb-44 233 28 of of ADP njb-44 233 29     SPACE njb-44 233 30 cd45 cd45 PROPN njb-44 233 31     SPACE njb-44 233 32 protein protein NOUN njb-44 233 33     SPACE njb-44 233 34 tyrosine tyrosine NOUN njb-44 233 35     SPACE njb-44 233 36 phosphatase phosphatase NOUN njb-44 233 37     SPACE njb-44 233 38 activity activity NOUN njb-44 233 39     SPACE njb-44 233 40 to to ADP njb-44 233 41     SPACE njb-44 233 42 lipid lipid NOUN njb-44 233 43     SPACE njb-44 233 44 microdomains microdomain NOUN njb-44 233 45     SPACE njb-44 233 46 on on ADP njb-44 233 47     SPACE njb-44 233 48 the the DET njb-44 233 49     SPACE njb-44 233 50 t t PROPN njb-44 233 51     SPACE njb-44 233 52 cell cell NOUN njb-44 233 53     SPACE njb-44 233 54 surface surface NOUN njb-44 233 55     SPACE njb-44 233 56 inhibits inhibit NOUN njb-44 233 57     SPACE njb-44 233 58 tcr tcr PROPN njb-44 233 59     SPACE njb-44 233 60 signaling signal VERB njb-44 233 61 . . PUNCT njb-44 233 62     SPACE njb-44 234 1 european european PROPN njb-44 234 2     SPACE njb-44 234 3 journal journal PROPN njb-44 234 4     SPACE njb-44 234 5 of of ADP njb-44 234 6     SPACE njb-44 234 7 immunology immunology NOUN njb-44 234 8     SPACE njb-44 234 9 2002 2002 NUM njb-44 234 10 , , PUNCT njb-44 234 11     SPACE njb-44 234 12 32(9):2578-­‐2587 32(9):2578-­‐2587 NUM njb-44 234 13 . . PUNCT njb-44 234 14         SPACE njb-44 234 15 39 39 NUM njb-44 234 16 . . PUNCT njb-44 234 17 veri veri VERB njb-44 234 18     SPACE njb-44 234 19 mc mc PROPN njb-44 234 20 , , PUNCT njb-44 234 21     SPACE njb-44 234 22 debell debell PROPN njb-44 234 23     SPACE njb-44 234 24 ke ke PROPN njb-44 234 25 , , PUNCT njb-44 234 26     SPACE njb-44 234 27 seminario seminario NOUN njb-44 234 28     SPACE njb-44 234 29 mc mc PROPN njb-44 234 30 , , PUNCT njb-44 234 31     SPACE njb-44 234 32 dibaldassarre dibaldassarre PROPN njb-44 234 33     SPACE njb-44 234 34 a a DET njb-44 234 35 , , PUNCT njb-44 234 36     SPACE njb-44 234 37 reischl reischl PROPN njb-44 234 38     SPACE njb-44 234 39 i i PRON njb-44 234 40 , , PUNCT njb-44 234 41     SPACE njb-44 234 42 rawat rawat NOUN njb-44 234 43     SPACE njb-44 234 44 r r NOUN njb-44 234 45 , , PUNCT njb-44 234 46     SPACE njb-44 234 47 graham graham PROPN njb-44 234 48     SPACE njb-44 234 49 l l PROPN njb-44 234 50 , , PUNCT njb-44 234 51     SPACE njb-44 234 52 noviello noviello PROPN njb-44 234 53     SPACE njb-44 234 54 c c PROPN njb-44 234 55 , , PUNCT njb-44 234 56     SPACE njb-44 234 57 rellahan rellahan PROPN njb-44 234 58     SPACE njb-44 234 59 bl bl PROPN njb-44 234 60 , , PUNCT njb-44 234 61     SPACE njb-44 234 62 miscia miscia PROPN njb-44 234 63     SPACE njb-44 234 64 s s PROPN njb-44 234 65     SPACE njb-44 234 66 et et NOUN njb-44 234 67     SPACE njb-44 234 68 al al PROPN njb-44 234 69 : : PUNCT njb-44 234 70     SPACE njb-44 234 71 membrane membrane NOUN njb-44 234 72     SPACE njb-44 234 73 raft-­‐dependent raft-­‐dependent NOUN njb-44 234 74     SPACE njb-44 234 75 regulation regulation NOUN njb-44 234 76     SPACE njb-44 234 77 of of ADP njb-44 234 78     SPACE njb-44 234 79 phospholipase phospholipase NOUN njb-44 234 80     SPACE njb-44 234 81 cgamma-­‐1 cgamma-­‐1 VERB njb-44 234 82     SPACE njb-44 234 83 activation activation NOUN njb-44 234 84     SPACE njb-44 234 85 in in ADP njb-44 234 86     SPACE njb-44 234 87 t t NOUN njb-44 234 88     SPACE njb-44 234 89 lymphocytes lymphocyte NOUN njb-44 234 90 . . PUNCT njb-44 234 91     SPACE njb-44 235 1 molecular molecular ADJ njb-44 235 2     SPACE njb-44 235 3 and and CCONJ njb-44 235 4     SPACE njb-44 235 5 cellular cellular ADJ njb-44 235 6     SPACE njb-44 235 7 biology biology NOUN njb-44 235 8     SPACE njb-44 235 9 2001 2001 NUM njb-44 235 10 , , PUNCT njb-44 235 11     SPACE njb-44 235 12 21(20):6939-­‐6950 21(20):6939-­‐6950 NUM njb-44 235 13 . . PUNCT njb-44 235 14         SPACE njb-44 236 1 40 40 NUM njb-44 236 2 . . PUNCT njb-44 237 1 werlen werlen PROPN njb-44 237 2     SPACE njb-44 237 3 g g PROPN njb-44 237 4 , , PUNCT njb-44 237 5     SPACE njb-44 237 6 hausmann hausmann PROPN njb-44 237 7     SPACE njb-44 237 8 b b PROPN njb-44 237 9 , , PUNCT njb-44 237 10     SPACE njb-44 237 11 palmer palmer PROPN njb-44 237 12     SPACE njb-44 237 13 e e PROPN njb-44 237 14 : : PUNCT njb-44 237 15     SPACE njb-44 237 16 a a DET njb-44 237 17     SPACE njb-44 237 18 motif motif NOUN njb-44 237 19     SPACE njb-44 237 20 in in ADP njb-44 237 21     SPACE njb-44 237 22 the the DET njb-44 237 23     SPACE njb-44 237 24 alphabeta alphabeta ADJ njb-44 237 25     SPACE njb-44 237 26 t-­‐cell t-­‐cell PROPN njb-44 237 27     SPACE njb-44 237 28 receptor receptor NOUN njb-44 237 29     SPACE njb-44 237 30 controls control VERB njb-44 237 31     SPACE njb-44 237 32 positive positive ADJ njb-44 237 33     SPACE njb-44 237 34 selection selection NOUN njb-44 237 35     SPACE njb-44 237 36 by by ADP njb-44 237 37     SPACE njb-44 237 38 modulating modulate VERB njb-44 237 39     SPACE njb-44 237 40 erk erk NOUN njb-44 237 41     SPACE njb-44 237 42 activity activity NOUN njb-44 237 43 . . PUNCT njb-44 237 44     SPACE njb-44 238 1 nature nature NOUN njb-44 238 2     SPACE njb-44 238 3 2000 2000 NUM njb-44 238 4 , , PUNCT njb-44 238 5     SPACE njb-44 238 6 406:422-­‐426 406:422-­‐426 NUM njb-44 238 7 . . PUNCT njb-44 238 8         SPACE