id sid tid token lemma pos njb-56 1 1 3 3 NUM njb-56 1 2 nepal nepal ADJ njb-56 1 3     SPACE njb-56 1 4 journal journal NOUN njb-56 1 5     SPACE njb-56 1 6 of of ADP njb-56 1 7     SPACE njb-56 1 8 biotechnology biotechnology NOUN njb-56 1 9 . . PUNCT njb-56 1 10     SPACE njb-56 2 1 jan jan PROPN njb-56 2 2 . . PROPN njb-56 2 3     SPACE njb-56 2 4 2011 2011 NUM njb-56 2 5 , , PUNCT njb-56 2 6     SPACE njb-56 2 7 vol vol NOUN njb-56 2 8 . . PUNCT njb-56 2 9     SPACE njb-56 2 10 1 1 NUM njb-56 2 11 , , PUNCT njb-56 2 12     SPACE njb-56 2 13 no no INTJ njb-56 2 14 . . PUNCT njb-56 2 15     SPACE njb-56 3 1 1 1 X njb-56 3 2     SPACE njb-56 3 3 : : PUNCT njb-56 3 4     SPACE njb-56 3 5 14‐21 14‐21 NUM njb-56 3 6     SPACE njb-56 3 7 14 14 NUM njb-56 3 8       SPACE njb-56 3 9 biotechnology biotechnology NOUN njb-56 3 10     SPACE njb-56 3 11 society society NOUN njb-56 3 12     SPACE njb-56 3 13 of of ADP njb-56 3 14     SPACE njb-56 3 15 nepal nepal NOUN njb-56 3 16     SPACE njb-56 3 17 ( ( PUNCT njb-56 3 18 bsn bsn PROPN njb-56 3 19 ) ) PUNCT njb-56 3 20 , , PUNCT njb-56 3 21     SPACE njb-56 3 22 all all DET njb-56 3 23     SPACE njb-56 3 24 rights right NOUN njb-56 3 25     SPACE njb-56 3 26 reserved reserve VERB njb-56 3 27       SPACE njb-56 3 28 original original ADJ njb-56 3 29     SPACE njb-56 3 30 research research NOUN njb-56 3 31     SPACE njb-56 3 32 article article NOUN njb-56 3 33     SPACE njb-56 3 34 analysis analysis NOUN njb-56 3 35     SPACE njb-56 3 36 of of ADP njb-56 3 37     SPACE njb-56 3 38 katg katg PROPN njb-56 3 39     SPACE njb-56 3 40 ser315thr ser315thr PROPN njb-56 3 41     SPACE njb-56 3 42 mutation mutation NOUN njb-56 3 43     SPACE njb-56 3 44 in in ADP njb-56 3 45     SPACE njb-56 3 46 multidrug multidrug NOUN njb-56 3 47     SPACE njb-56 3 48 resistant resistant ADJ njb-56 3 49     SPACE njb-56 3 50 mycobacterium mycobacterium NOUN njb-56 3 51     SPACE njb-56 3 52 tuberculosis tuberculosis NOUN njb-56 3 53     SPACE njb-56 3 54 and and CCONJ njb-56 3 55     SPACE njb-56 3 56 slc11a1 slc11a1 NOUN njb-56 3 57     SPACE njb-56 3 58 polymorphism polymorphism NOUN njb-56 3 59     SPACE njb-56 3 60 in in ADP njb-56 3 61     SPACE njb-56 3 62 multidrug multidrug NOUN njb-56 3 63     SPACE njb-56 3 64 resistance resistance NOUN njb-56 3 65     SPACE njb-56 3 66 tuberculosis tuberculosis NOUN njb-56 3 67     SPACE njb-56 3 68 in in ADP njb-56 3 69     SPACE njb-56 3 70 central central ADJ njb-56 3 71     SPACE njb-56 3 72 development development NOUN njb-56 3 73     SPACE njb-56 3 74 region region NOUN njb-56 3 75     SPACE njb-56 3 76 of of ADP njb-56 3 77     SPACE njb-56 3 78 nepal nepal ADJ njb-56 3 79     SPACE njb-56 3 80 using use VERB njb-56 3 81     SPACE njb-56 3 82 pcr‐rflp pcr‐rflp ADJ njb-56 3 83     SPACE njb-56 3 84 technique technique NOUN njb-56 3 85 : : PUNCT njb-56 3 86     SPACE njb-56 3 87 a a DET njb-56 3 88     SPACE njb-56 3 89 pilot pilot NOUN njb-56 3 90     SPACE njb-56 3 91 study study NOUN njb-56 3 92     SPACE njb-56 3 93 raunak raunak PROPN njb-56 3 94     SPACE njb-56 3 95 shrestha1 shrestha1 PROPN njb-56 3 96 , , PUNCT njb-56 3 97     SPACE njb-56 3 98 rubin rubin PROPN njb-56 3 99     SPACE njb-56 3 100 narayan narayan PROPN njb-56 3 101     SPACE njb-56 3 102 joshi1 joshi1 PROPN njb-56 3 103 , , PUNCT njb-56 3 104     SPACE njb-56 3 105 kriti kriti PROPN njb-56 3 106     SPACE njb-56 3 107 joshi1 joshi1 PROPN njb-56 3 108 , , PUNCT njb-56 3 109     SPACE njb-56 3 110 bal bal PROPN njb-56 3 111     SPACE njb-56 3 112 hari hari NOUN njb-56 3 113     SPACE njb-56 3 114 poudel2 poudel2 NOUN njb-56 3 115     SPACE njb-56 3 116 and and CCONJ njb-56 3 117     SPACE njb-56 3 118 bhupal bhupal ADJ njb-56 3 119     SPACE njb-56 3 120 govinda govinda PROPN njb-56 3 121     SPACE njb-56 3 122 shrestha1 shrestha1 PROPN njb-56 3 123     SPACE njb-56 3 124 1 1 NUM njb-56 3 125     SPACE njb-56 3 126 department department NOUN njb-56 3 127     SPACE njb-56 3 128 of of ADP njb-56 3 129     SPACE njb-56 3 130 biotechnology biotechnology NOUN njb-56 3 131 , , PUNCT njb-56 3 132     SPACE njb-56 3 133 kathmandu kathmandu NOUN njb-56 3 134     SPACE njb-56 3 135 university university NOUN njb-56 3 136 , , PUNCT njb-56 3 137     SPACE njb-56 3 138 dhulikhel dhulikhel PROPN njb-56 3 139 , , PUNCT njb-56 3 140     SPACE njb-56 3 141 nepal nepal ADJ njb-56 3 142 . . PUNCT njb-56 3 143     SPACE njb-56 3 144 2 2 NUM njb-56 3 145     SPACE njb-56 3 146 genetics genetic NOUN njb-56 3 147     SPACE njb-56 3 148 nepal nepal ADJ njb-56 3 149     SPACE njb-56 3 150 pvt pvt PROPN njb-56 3 151 . . PUNCT njb-56 3 152     SPACE njb-56 3 153 ltd ltd PROPN njb-56 3 154 . . PROPN njb-56 3 155 , , PUNCT njb-56 3 156     SPACE njb-56 3 157 lalitpur lalitpur PROPN njb-56 3 158 , , PUNCT njb-56 3 159     SPACE njb-56 3 160 nepal nepal ADJ njb-56 3 161 . . PUNCT njb-56 3 162     SPACE njb-56 4 1 abstract abstract ADJ njb-56 4 2     SPACE njb-56 4 3 ser315thr ser315thr NOUN njb-56 4 4     SPACE njb-56 4 5 mutations mutation NOUN njb-56 4 6     SPACE njb-56 4 7 in in ADP njb-56 4 8     SPACE njb-56 4 9 genes gene NOUN njb-56 4 10     SPACE njb-56 4 11 encoding encode VERB njb-56 4 12     SPACE njb-56 4 13 the the DET njb-56 4 14     SPACE njb-56 4 15 mycobacteria mycobacteria PROPN njb-56 4 16     SPACE njb-56 4 17 catalase‐peroxidase catalase‐peroxidase PROPN njb-56 4 18     SPACE njb-56 4 19 ( ( PUNCT njb-56 4 20 katg katg PROPN njb-56 4 21 ) ) PUNCT njb-56 4 22     SPACE njb-56 4 23 has have AUX njb-56 4 24     SPACE njb-56 4 25 been be AUX njb-56 4 26     SPACE njb-56 4 27 associated associate VERB njb-56 4 28     SPACE njb-56 4 29 with with ADP njb-56 4 30     SPACE njb-56 4 31 the the DET njb-56 4 32     SPACE njb-56 4 33 major major ADJ njb-56 4 34     SPACE njb-56 4 35 resistance resistance NOUN njb-56 4 36     SPACE njb-56 4 37 to to ADP njb-56 4 38     SPACE njb-56 4 39 isoniazid isoniazid PROPN njb-56 4 40     SPACE njb-56 4 41 ( ( PUNCT njb-56 4 42 inh inh PROPN njb-56 4 43 ) ) PUNCT njb-56 4 44     SPACE njb-56 4 45 in in ADP njb-56 4 46     SPACE njb-56 4 47 mycobacterium mycobacterium NOUN njb-56 4 48     SPACE njb-56 4 49 tuberculosis tuberculosis NOUN njb-56 4 50     SPACE njb-56 4 51 ( ( PUNCT njb-56 4 52 mtb mtb NOUN njb-56 4 53 ) ) PUNCT njb-56 4 54 . . PUNCT njb-56 4 55     SPACE njb-56 5 1 also also ADV njb-56 5 2     SPACE njb-56 5 3 g g X njb-56 5 4 / / SYM njb-56 5 5 c c NOUN njb-56 5 6     SPACE njb-56 5 7 polymorphisms polymorphism NOUN njb-56 5 8     SPACE njb-56 5 9 in in ADP njb-56 5 10     SPACE njb-56 5 11 int4 int4 PROPN njb-56 5 12     SPACE njb-56 5 13 region region NOUN njb-56 5 14     SPACE njb-56 5 15 of of ADP njb-56 5 16     SPACE njb-56 5 17 the the DET njb-56 5 18     SPACE njb-56 5 19 solute solute ADJ njb-56 5 20     SPACE njb-56 5 21 carrier carrier NOUN njb-56 5 22     SPACE njb-56 5 23 family family NOUN njb-56 5 24     SPACE njb-56 5 25 11 11 NUM njb-56 5 26     SPACE njb-56 5 27 member member NOUN njb-56 5 28     SPACE njb-56 5 29 1 1 NUM njb-56 5 30     SPACE njb-56 5 31 gene gene NOUN njb-56 5 32     SPACE njb-56 5 33 ( ( PUNCT njb-56 5 34 slc11a1 slc11a1 PROPN njb-56 5 35 ) ) PUNCT njb-56 5 36     SPACE njb-56 5 37 and and CCONJ njb-56 5 38     SPACE njb-56 5 39 susceptibility susceptibility NOUN njb-56 5 40     SPACE njb-56 5 41 towards towards ADP njb-56 5 42     SPACE njb-56 5 43 tuberculosis tuberculosis NOUN njb-56 5 44     SPACE njb-56 5 45 ( ( PUNCT njb-56 5 46 tb tb PROPN njb-56 5 47 ) ) PUNCT njb-56 5 48     SPACE njb-56 5 49 has have AUX njb-56 5 50     SPACE njb-56 5 51 been be AUX njb-56 5 52     SPACE njb-56 5 53 demonstrated demonstrate VERB njb-56 5 54     SPACE njb-56 5 55 worldwide worldwide ADV njb-56 5 56 . . PUNCT njb-56 5 57     SPACE njb-56 6 1 24 24 NUM njb-56 6 2     SPACE njb-56 6 3 drug drug NOUN njb-56 6 4     SPACE njb-56 6 5 resistant resistant ADJ njb-56 6 6     SPACE njb-56 6 7 mtb mtb NOUN njb-56 6 8     SPACE njb-56 6 9 culture culture NOUN njb-56 6 10     SPACE njb-56 6 11 positive positive ADJ njb-56 6 12     SPACE njb-56 6 13 samples sample NOUN njb-56 6 14     SPACE njb-56 6 15 and and CCONJ njb-56 6 16     SPACE njb-56 6 17 24 24 NUM njb-56 6 18     SPACE njb-56 6 19 whole‐blood whole‐blood NOUN njb-56 6 20     SPACE njb-56 6 21 samples sample NOUN njb-56 6 22     SPACE njb-56 6 23 were be AUX njb-56 6 24     SPACE njb-56 6 25 collected collect VERB njb-56 6 26     SPACE njb-56 6 27 from from ADP njb-56 6 28     SPACE njb-56 6 29 different different ADJ njb-56 6 30     SPACE njb-56 6 31 tb tb PROPN njb-56 6 32     SPACE njb-56 6 33 patients patient NOUN njb-56 6 34     SPACE njb-56 6 35 of of ADP njb-56 6 36     SPACE njb-56 6 37 central central ADJ njb-56 6 38     SPACE njb-56 6 39 development development NOUN njb-56 6 40     SPACE njb-56 6 41 region region NOUN njb-56 6 42     SPACE njb-56 6 43 of of ADP njb-56 6 44     SPACE njb-56 6 45 nepal nepal NOUN njb-56 6 46     SPACE njb-56 6 47 in in ADP njb-56 6 48     SPACE njb-56 6 49 2009 2009 NUM njb-56 6 50 . . PUNCT njb-56 6 51     SPACE njb-56 7 1 a a DET njb-56 7 2     SPACE njb-56 7 3 polymerase polymerase NOUN njb-56 7 4     SPACE njb-56 7 5 chain chain NOUN njb-56 7 6     SPACE njb-56 7 7 reaction reaction NOUN njb-56 7 8     SPACE njb-56 7 9 ( ( PUNCT njb-56 7 10 pcr pcr PROPN njb-56 7 11 ) ) PUNCT njb-56 7 12     SPACE njb-56 7 13 ‐ ‐ AUX njb-56 7 14     SPACE njb-56 7 15 restriction restriction NOUN njb-56 7 16     SPACE njb-56 7 17 fragment fragment ADJ njb-56 7 18     SPACE njb-56 7 19 length length NOUN njb-56 7 20     SPACE njb-56 7 21 polymorphism polymorphism NOUN njb-56 7 22     SPACE njb-56 7 23 ( ( PUNCT njb-56 7 24 rflp rflp NOUN njb-56 7 25 ) ) PUNCT njb-56 7 26     SPACE njb-56 7 27 assay assay PROPN njb-56 7 28     SPACE njb-56 7 29 was be AUX njb-56 7 30     SPACE njb-56 7 31 carried carry VERB njb-56 7 32     SPACE njb-56 7 33 out out ADP njb-56 7 34     SPACE njb-56 7 35 in in ADP njb-56 7 36     SPACE njb-56 7 37 order order NOUN njb-56 7 38     SPACE njb-56 7 39 to to PART njb-56 7 40     SPACE njb-56 7 41 investigate investigate VERB njb-56 7 42     SPACE njb-56 7 43 ser315thr ser315thr PROPN njb-56 7 44     SPACE njb-56 7 45 katg katg PROPN njb-56 7 46     SPACE njb-56 7 47 mutation mutation PROPN njb-56 7 48     SPACE njb-56 7 49 and and CCONJ njb-56 7 50     SPACE njb-56 7 51 g g X njb-56 7 52 / / SYM njb-56 7 53 c c NOUN njb-56 7 54     SPACE njb-56 7 55 polymorphism polymorphism NOUN njb-56 7 56     SPACE njb-56 7 57 in in ADP njb-56 7 58     SPACE njb-56 7 59 int4 int4 PROPN njb-56 7 60     SPACE njb-56 7 61 region region NOUN njb-56 7 62 . . PUNCT njb-56 7 63     SPACE njb-56 8 1 4 4 NUM njb-56 8 2     SPACE njb-56 8 3 ( ( PUNCT njb-56 8 4 16.67 16.67 NUM njb-56 8 5 % % NOUN njb-56 8 6 ) ) PUNCT njb-56 8 7     SPACE njb-56 8 8 samples sample NOUN njb-56 8 9     SPACE njb-56 8 10 out out ADP njb-56 8 11     SPACE njb-56 8 12 of of ADP njb-56 8 13     SPACE njb-56 8 14 24 24 NUM njb-56 8 15     SPACE njb-56 8 16 mtb mtb NOUN njb-56 8 17     SPACE njb-56 8 18 culture culture NOUN njb-56 8 19     SPACE njb-56 8 20 samples sample NOUN njb-56 8 21     SPACE njb-56 8 22 demonstrated demonstrate VERB njb-56 8 23     SPACE njb-56 8 24 the the DET njb-56 8 25     SPACE njb-56 8 26 ser315thr ser315thr NOUN njb-56 8 27     SPACE njb-56 8 28 katg katg PROPN njb-56 8 29     SPACE njb-56 8 30 mutation mutation NOUN njb-56 8 31     SPACE njb-56 8 32 whereas whereas SCONJ njb-56 8 33     SPACE njb-56 8 34 none none NOUN njb-56 8 35     SPACE njb-56 8 36 of of ADP njb-56 8 37     SPACE njb-56 8 38 the the DET njb-56 8 39     SPACE njb-56 8 40 24 24 NUM njb-56 8 41     SPACE njb-56 8 42 whole whole ADJ njb-56 8 43     SPACE njb-56 8 44 blood blood NOUN njb-56 8 45     SPACE njb-56 8 46 samples sample NOUN njb-56 8 47     SPACE njb-56 8 48 were be AUX njb-56 8 49     SPACE njb-56 8 50 found find VERB njb-56 8 51     SPACE njb-56 8 52 to to PART njb-56 8 53     SPACE njb-56 8 54 contain contain VERB njb-56 8 55     SPACE njb-56 8 56 g g SYM njb-56 8 57 / / SYM njb-56 8 58 c c NOUN njb-56 8 59     SPACE njb-56 8 60 polymorphism polymorphism NOUN njb-56 8 61     SPACE njb-56 8 62 in in ADP njb-56 8 63     SPACE njb-56 8 64 int4 int4 PROPN njb-56 8 65 . . PUNCT njb-56 8 66     SPACE njb-56 8 67 though though SCONJ njb-56 8 68     SPACE njb-56 8 69 no no DET njb-56 8 70     SPACE njb-56 8 71 significant significant ADJ njb-56 8 72     SPACE njb-56 8 73 correlation correlation NOUN njb-56 8 74     SPACE njb-56 8 75 could could AUX njb-56 8 76     SPACE njb-56 8 77 be be AUX njb-56 8 78     SPACE njb-56 8 79 found find VERB njb-56 8 80     SPACE njb-56 8 81 between between ADP njb-56 8 82     SPACE njb-56 8 83 int4 int4 PROPN njb-56 8 84     SPACE njb-56 8 85 polymorphism polymorphism NOUN njb-56 8 86     SPACE njb-56 8 87 and and CCONJ njb-56 8 88     SPACE njb-56 8 89 tb tb PROPN njb-56 8 90     SPACE njb-56 8 91 susceptibility susceptibility NOUN njb-56 8 92 , , PUNCT njb-56 8 93     SPACE njb-56 8 94 overall overall ADJ njb-56 8 95     SPACE njb-56 8 96 scenario scenario NOUN njb-56 8 97     SPACE njb-56 8 98 of of ADP njb-56 8 99     SPACE njb-56 8 100 nepal nepal NOUN njb-56 8 101     SPACE njb-56 8 102 can can AUX njb-56 8 103 not not PART njb-56 8 104     SPACE njb-56 8 105 be be AUX njb-56 8 106     SPACE njb-56 8 107 drawn draw VERB njb-56 8 108     SPACE njb-56 8 109 from from ADP njb-56 8 110     SPACE njb-56 8 111 this this DET njb-56 8 112     SPACE njb-56 8 113 data datum NOUN njb-56 8 114 . . PUNCT njb-56 8 115     SPACE njb-56 8 116 molecular molecular ADJ njb-56 8 117     SPACE njb-56 8 118 diagnostic diagnostic ADJ njb-56 8 119     SPACE njb-56 8 120 technique technique NOUN njb-56 8 121     SPACE njb-56 8 122 such such ADJ njb-56 8 123     SPACE njb-56 8 124 as as ADV njb-56 8 125     SPACE njb-56 8 126 pcr‐rflp pcr‐rflp PROPN njb-56 8 127     SPACE njb-56 8 128 can can AUX njb-56 8 129     SPACE njb-56 8 130 be be AUX njb-56 8 131     SPACE njb-56 8 132 used use VERB njb-56 8 133     SPACE njb-56 8 134 in in ADP njb-56 8 135     SPACE njb-56 8 136 a a DET njb-56 8 137     SPACE njb-56 8 138 robust robust ADJ njb-56 8 139     SPACE njb-56 8 140 scale scale NOUN njb-56 8 141     SPACE njb-56 8 142 to to PART njb-56 8 143     SPACE njb-56 8 144 carry carry VERB njb-56 8 145     SPACE njb-56 8 146 out out ADP njb-56 8 147     SPACE njb-56 8 148 base base NOUN njb-56 8 149     SPACE njb-56 8 150 line line NOUN njb-56 8 151     SPACE njb-56 8 152 studies study NOUN njb-56 8 153     SPACE njb-56 8 154 in in ADP njb-56 8 155     SPACE njb-56 8 156 the the DET njb-56 8 157     SPACE njb-56 8 158 tb tb PROPN njb-56 8 159     SPACE njb-56 8 160 population population NOUN njb-56 8 161     SPACE njb-56 8 162 of of ADP njb-56 8 163     SPACE njb-56 8 164 nepal nepal ADJ njb-56 8 165 . . PUNCT njb-56 8 166         SPACE njb-56 8 167 key key ADJ njb-56 8 168     SPACE njb-56 8 169 words word NOUN njb-56 8 170 : : PUNCT njb-56 8 171     SPACE njb-56 8 172 multi‐drug multi‐drug PROPN njb-56 8 173     SPACE njb-56 8 174 resistance resistance NOUN njb-56 8 175 , , PUNCT njb-56 8 176     SPACE njb-56 8 177 tuberculosis tuberculosis NOUN njb-56 8 178 , , PUNCT njb-56 8 179     SPACE njb-56 8 180 pcr pcr PROPN njb-56 8 181 , , PUNCT njb-56 8 182     SPACE njb-56 8 183 rflp rflp NOUN njb-56 8 184         SPACE njb-56 8 185 correspondence correspondence NOUN njb-56 8 186     SPACE njb-56 8 187 author author NOUN njb-56 8 188 : : PUNCT njb-56 8 189     SPACE njb-56 8 190 e‐mail e‐mail NOUN njb-56 8 191 : : PUNCT njb-56 8 192     SPACE njb-56 8 193 sraunak@gmail.com sraunak@gmail.com X njb-56 8 194     SPACE njb-56 8 195 introduction introduction NOUN njb-56 8 196     SPACE njb-56 8 197 during during ADP njb-56 8 198     SPACE njb-56 8 199 the the DET njb-56 8 200     SPACE njb-56 8 201 last last ADJ njb-56 8 202     SPACE njb-56 8 203 decades decade NOUN njb-56 8 204 , , PUNCT njb-56 8 205     SPACE njb-56 8 206 incidence incidence NOUN njb-56 8 207     SPACE njb-56 8 208 of of ADP njb-56 8 209     SPACE njb-56 8 210 tuberculosis tuberculosis NOUN njb-56 8 211     SPACE njb-56 8 212 ( ( PUNCT njb-56 8 213 tb tb PROPN njb-56 8 214 ) ) PUNCT njb-56 8 215     SPACE njb-56 8 216 has have AUX njb-56 8 217     SPACE njb-56 8 218 increased increase VERB njb-56 8 219     SPACE njb-56 8 220 in in ADP njb-56 8 221     SPACE njb-56 8 222 many many ADJ njb-56 8 223     SPACE njb-56 8 224 countries country NOUN njb-56 8 225     SPACE njb-56 8 226 and and CCONJ njb-56 8 227     SPACE njb-56 8 228 more more ADJ njb-56 8 229     SPACE njb-56 8 230 people people NOUN njb-56 8 231     SPACE njb-56 8 232 have have VERB njb-56 8 233     SPACE njb-56 8 234 the the DET njb-56 8 235     SPACE njb-56 8 236 disease disease NOUN njb-56 8 237     SPACE njb-56 8 238 now now ADV njb-56 8 239     SPACE njb-56 8 240 than than ADP njb-56 8 241     SPACE njb-56 8 242 at at ADP njb-56 8 243     SPACE njb-56 8 244 any any DET njb-56 8 245     SPACE njb-56 8 246 other other ADJ njb-56 8 247     SPACE njb-56 8 248 time time NOUN njb-56 8 249     SPACE njb-56 8 250 in in ADP njb-56 8 251     SPACE njb-56 8 252 history history NOUN njb-56 8 253 . . PUNCT njb-56 8 254     SPACE njb-56 9 1 it it PRON njb-56 9 2     SPACE njb-56 9 3 is be AUX njb-56 9 4     SPACE njb-56 9 5 estimated estimate VERB njb-56 9 6     SPACE njb-56 9 7 that that SCONJ njb-56 9 8     SPACE njb-56 9 9 tb tb PROPN njb-56 9 10     SPACE njb-56 9 11 still still ADV njb-56 9 12     SPACE njb-56 9 13 kills kill VERB njb-56 9 14     SPACE njb-56 9 15 more more ADJ njb-56 9 16     SPACE njb-56 9 17 people people NOUN njb-56 9 18     SPACE njb-56 9 19 globally globally ADV njb-56 9 20     SPACE njb-56 9 21 than than ADP njb-56 9 22     SPACE njb-56 9 23 any any DET njb-56 9 24     SPACE njb-56 9 25 other other ADJ njb-56 9 26     SPACE njb-56 9 27 infection infection NOUN njb-56 9 28     SPACE njb-56 9 29 ( ( PUNCT njb-56 9 30 who who PRON njb-56 9 31 , , PUNCT njb-56 9 32     SPACE njb-56 9 33 2009 2009 NUM njb-56 9 34 ) ) PUNCT njb-56 9 35 . . PUNCT njb-56 9 36     SPACE njb-56 10 1 the the DET njb-56 10 2     SPACE njb-56 10 3 situation situation NOUN njb-56 10 4     SPACE njb-56 10 5 has have AUX njb-56 10 6     SPACE njb-56 10 7 worsened worsen VERB njb-56 10 8     SPACE njb-56 10 9 by by ADP njb-56 10 10     SPACE njb-56 10 11 the the DET njb-56 10 12     SPACE njb-56 10 13 emergence emergence NOUN njb-56 10 14     SPACE njb-56 10 15 of of ADP njb-56 10 16     SPACE njb-56 10 17 antibiotic‐resistant antibiotic‐resistant ADJ njb-56 10 18     SPACE njb-56 10 19 strains strain NOUN njb-56 10 20     SPACE njb-56 10 21 of of ADP njb-56 10 22     SPACE njb-56 10 23 mycobacterium mycobacterium NOUN njb-56 10 24     SPACE njb-56 10 25 tuberculosis tuberculosis NOUN njb-56 10 26     SPACE njb-56 10 27 ( ( PUNCT njb-56 10 28 mtb mtb NOUN njb-56 10 29 ) ) PUNCT njb-56 10 30     SPACE njb-56 10 31 ( ( PUNCT njb-56 10 32 musser musser PROPN njb-56 10 33 , , PUNCT njb-56 10 34     SPACE njb-56 10 35 1995 1995 NUM njb-56 10 36 ) ) PUNCT njb-56 10 37 . . PUNCT njb-56 10 38     SPACE njb-56 11 1 the the DET njb-56 11 2     SPACE njb-56 11 3 strains strain NOUN njb-56 11 4     SPACE njb-56 11 5 resistant resistant ADJ njb-56 11 6     SPACE njb-56 11 7 to to ADP njb-56 11 8     SPACE njb-56 11 9 the the DET njb-56 11 10     SPACE njb-56 11 11 two two NUM njb-56 11 12     SPACE njb-56 11 13 most most ADJ njb-56 11 14     SPACE njb-56 11 15 important important ADJ njb-56 11 16     SPACE njb-56 11 17 anti‐tb anti‐tb ADJ njb-56 11 18     SPACE njb-56 11 19 drugs drug NOUN njb-56 11 20 , , PUNCT njb-56 11 21     SPACE njb-56 11 22 rifampin rifampin PROPN njb-56 11 23     SPACE njb-56 11 24 ( ( PUNCT njb-56 11 25 rif rif NOUN njb-56 11 26 ) ) PUNCT njb-56 11 27     SPACE njb-56 11 28 and and CCONJ njb-56 11 29     SPACE njb-56 11 30 isoniazid isoniazid PROPN njb-56 11 31     SPACE njb-56 11 32 ( ( PUNCT njb-56 11 33 inh inh PROPN njb-56 11 34 ) ) PUNCT njb-56 11 35     SPACE njb-56 11 36 are be AUX njb-56 11 37     SPACE njb-56 11 38 commonly commonly ADV njb-56 11 39     SPACE njb-56 11 40 defined define VERB njb-56 11 41     SPACE njb-56 11 42 as as SCONJ njb-56 11 43     SPACE njb-56 11 44 multidrug multidrug NOUN njb-56 11 45     SPACE njb-56 11 46 resistant resistant ADJ njb-56 11 47     SPACE njb-56 11 48 ( ( PUNCT njb-56 11 49 mdr mdr PROPN njb-56 11 50 ) ) PUNCT njb-56 11 51 . . PUNCT njb-56 11 52     SPACE njb-56 12 1 drug drug NOUN njb-56 12 2     SPACE njb-56 12 3 resistance resistance NOUN njb-56 12 4     SPACE njb-56 12 5 in in ADP njb-56 12 6     SPACE njb-56 12 7 m. m. NOUN njb-56 12 8     SPACE njb-56 12 9 tuberculosis tuberculosis NOUN njb-56 12 10     SPACE njb-56 12 11 is be AUX njb-56 12 12     SPACE njb-56 12 13 attributed attribute VERB njb-56 12 14     SPACE njb-56 12 15 primarily primarily ADV njb-56 12 16     SPACE njb-56 12 17 to to ADP njb-56 12 18     SPACE njb-56 12 19 the the DET njb-56 12 20     SPACE njb-56 12 21 accumulation accumulation NOUN njb-56 12 22     SPACE njb-56 12 23 of of ADP njb-56 12 24     SPACE njb-56 12 25 mutations mutation NOUN njb-56 12 26     SPACE njb-56 12 27 in in ADP njb-56 12 28     SPACE njb-56 12 29 the the DET njb-56 12 30     SPACE njb-56 12 31 drug drug NOUN njb-56 12 32     SPACE njb-56 12 33 target target NOUN njb-56 12 34     SPACE njb-56 12 35 genes gene NOUN njb-56 12 36 ; ; PUNCT njb-56 12 37     SPACE njb-56 12 38 these these DET njb-56 12 39     SPACE njb-56 12 40 mutations mutation NOUN njb-56 12 41     SPACE njb-56 12 42 either either CCONJ njb-56 12 43     SPACE njb-56 12 44 leading lead VERB njb-56 12 45     SPACE njb-56 12 46 to to ADP njb-56 12 47     SPACE njb-56 12 48 an an DET njb-56 12 49     SPACE njb-56 12 50 altered alter VERB njb-56 12 51     SPACE njb-56 12 52 target target NOUN njb-56 12 53     SPACE njb-56 12 54 or or CCONJ njb-56 12 55     SPACE njb-56 12 56 to to ADP njb-56 12 57     SPACE njb-56 12 58 an an DET njb-56 12 59     SPACE njb-56 12 60 alternation alternation NOUN njb-56 12 61     SPACE njb-56 12 62 in in ADP njb-56 12 63     SPACE njb-56 12 64 effective effective ADJ njb-56 12 65     SPACE njb-56 12 66 titration titration NOUN njb-56 12 67     SPACE njb-56 12 68 of of ADP njb-56 12 69     SPACE njb-56 12 70 the the DET njb-56 12 71     SPACE njb-56 12 72 drug drug NOUN njb-56 12 73     SPACE njb-56 12 74 ( ( PUNCT njb-56 12 75 rattan rattan PROPN njb-56 12 76     SPACE njb-56 12 77 et et PROPN njb-56 12 78     SPACE njb-56 12 79 al al PROPN njb-56 12 80 . . PROPN njb-56 12 81 , , PUNCT njb-56 12 82     SPACE njb-56 12 83 1998 1998 NUM njb-56 12 84 ) ) PUNCT njb-56 12 85 . . PUNCT njb-56 12 86       SPACE njb-56 13 1 in in ADP njb-56 13 2     SPACE njb-56 13 3 2008 2008 NUM njb-56 13 4 , , PUNCT njb-56 13 5     SPACE njb-56 13 6 there there PRON njb-56 13 7     SPACE njb-56 13 8 were be AUX njb-56 13 9     SPACE njb-56 13 10 an an DET njb-56 13 11     SPACE njb-56 13 12 estimated estimate VERB njb-56 13 13     SPACE njb-56 13 14 8.9–9.9 8.9–9.9 NUM njb-56 13 15     SPACE njb-56 13 16 million million NUM njb-56 13 17     SPACE njb-56 13 18 incident incident NOUN njb-56 13 19     SPACE njb-56 13 20 cases case NOUN njb-56 13 21     SPACE njb-56 13 22 of of ADP njb-56 13 23     SPACE njb-56 13 24 tb tb PROPN njb-56 13 25 , , PUNCT njb-56 13 26     SPACE njb-56 13 27 9.6–13.3 9.6–13.3 NUM njb-56 13 28     SPACE njb-56 13 29 million million NUM njb-56 13 30     SPACE njb-56 13 31 prevalent prevalent ADJ njb-56 13 32     SPACE njb-56 13 33 cases case NOUN njb-56 13 34     SPACE njb-56 13 35 of of ADP njb-56 13 36     SPACE njb-56 13 37 tb tb PROPN njb-56 13 38     SPACE njb-56 13 39 ( ( PUNCT njb-56 13 40 who who PRON njb-56 13 41 , , PUNCT njb-56 13 42     SPACE njb-56 13 43 2009 2009 NUM njb-56 13 44 ) ) PUNCT njb-56 13 45     SPACE njb-56 13 46 and and CCONJ njb-56 13 47     SPACE njb-56 13 48 390,000–510,000 390,000–510,000 NUM njb-56 13 49     SPACE njb-56 13 50 cases case NOUN njb-56 13 51     SPACE njb-56 13 52 of of ADP njb-56 13 53     SPACE njb-56 13 54 mdrtb mdrtb NOUN njb-56 13 55     SPACE njb-56 13 56 ( ( PUNCT njb-56 13 57 who who PRON njb-56 13 58 , , PUNCT njb-56 13 59     SPACE njb-56 13 60 2010 2010 NUM njb-56 13 61 ) ) PUNCT njb-56 13 62 . . PUNCT njb-56 13 63     SPACE njb-56 14 1 among among ADP njb-56 14 2     SPACE njb-56 14 3 the the DET njb-56 14 4     SPACE njb-56 14 5 incident incident NOUN njb-56 14 6     SPACE njb-56 14 7 tb tb PROPN njb-56 14 8     SPACE njb-56 14 9 cases case NOUN njb-56 14 10     SPACE njb-56 14 11 globally globally ADV njb-56 14 12 , , PUNCT njb-56 14 13     SPACE njb-56 14 14 3.6 3.6 NUM njb-56 14 15 % % NOUN njb-56 14 16     SPACE njb-56 14 17 ( ( PUNCT njb-56 14 18 95 95 NUM njb-56 14 19 % % NOUN njb-56 14 20     SPACE njb-56 14 21 confidence confidence NOUN njb-56 14 22     SPACE njb-56 14 23 interval interval NOUN njb-56 14 24     SPACE njb-56 14 25 ( ( PUNCT njb-56 14 26 ci ci PROPN njb-56 14 27 ): ): PUNCT njb-56 14 28     SPACE njb-56 14 29 3.0–4.4 3.0–4.4 NUM njb-56 14 30 ) ) PUNCT njb-56 14 31     SPACE njb-56 14 32 are be AUX njb-56 14 33     SPACE njb-56 14 34 estimated estimate VERB njb-56 14 35     SPACE njb-56 14 36 to to PART njb-56 14 37     SPACE njb-56 14 38 have have VERB njb-56 14 39     SPACE njb-56 14 40 mdr‐tb mdr‐tb ADJ njb-56 14 41 . . PUNCT njb-56 14 42     SPACE njb-56 14 43 almost almost ADV njb-56 14 44     SPACE njb-56 14 45 50 50 NUM njb-56 14 46 % % NOUN njb-56 14 47     SPACE njb-56 14 48 of of ADP njb-56 14 49     SPACE njb-56 14 50 mdr‐tb mdr‐tb ADJ njb-56 14 51     SPACE njb-56 14 52 cases case NOUN njb-56 14 53     SPACE njb-56 14 54 worldwide worldwide ADV njb-56 14 55     SPACE njb-56 14 56 are be AUX njb-56 14 57     SPACE njb-56 14 58 estimated estimate VERB njb-56 14 59     SPACE njb-56 14 60 to to PART njb-56 14 61     SPACE njb-56 14 62 occur occur VERB njb-56 14 63     SPACE njb-56 14 64 in in ADP njb-56 14 65     SPACE njb-56 14 66 china china PROPN njb-56 14 67     SPACE njb-56 14 68 and and CCONJ njb-56 14 69     SPACE njb-56 14 70 india india PROPN njb-56 14 71 . . PUNCT njb-56 14 72     SPACE njb-56 15 1 in in ADP njb-56 15 2     SPACE njb-56 15 3 2008 2008 NUM njb-56 15 4 , , PUNCT njb-56 15 5     SPACE njb-56 15 6 mdr‐tb mdr‐tb ADJ njb-56 15 7     SPACE njb-56 15 8 caused cause VERB njb-56 15 9     SPACE njb-56 15 10 an an DET njb-56 15 11     SPACE njb-56 15 12 estimated estimate VERB njb-56 15 13     SPACE njb-56 15 14 death death NOUN njb-56 15 15     SPACE njb-56 15 16 of of ADP njb-56 15 17     SPACE njb-56 15 18 150,000 150,000 NUM njb-56 15 19     SPACE njb-56 15 20 people people NOUN njb-56 15 21     SPACE njb-56 15 22 across across ADP njb-56 15 23     SPACE njb-56 15 24 the the DET njb-56 15 25     SPACE njb-56 15 26 globe globe NOUN njb-56 15 27     SPACE njb-56 15 28 ( ( PUNCT njb-56 15 29 who who PRON njb-56 15 30 , , PUNCT njb-56 15 31     SPACE njb-56 15 32 2010 2010 NUM njb-56 15 33 ) ) PUNCT njb-56 15 34 . . PUNCT njb-56 15 35       SPACE njb-56 15 36 who who PRON njb-56 15 37     SPACE njb-56 15 38 estimated estimate VERB njb-56 15 39     SPACE njb-56 15 40 the the DET njb-56 15 41     SPACE njb-56 15 42 prevalence prevalence NOUN njb-56 15 43     SPACE njb-56 15 44 of of ADP njb-56 15 45     SPACE njb-56 15 46 all all DET njb-56 15 47     SPACE njb-56 15 48 types type NOUN njb-56 15 49     SPACE njb-56 15 50 of of ADP njb-56 15 51     SPACE njb-56 15 52 tuberculosis tuberculosis NOUN njb-56 15 53     SPACE njb-56 15 54 cases case NOUN njb-56 15 55     SPACE njb-56 15 56 for for ADP njb-56 15 57     SPACE njb-56 15 58 nepal nepal NOUN njb-56 15 59     SPACE njb-56 15 60 to to PART njb-56 15 61     SPACE njb-56 15 62 be be AUX njb-56 15 63     SPACE njb-56 15 64 67,546 67,546 NUM njb-56 15 65     SPACE njb-56 15 66 nepal nepal ADJ njb-56 15 67     SPACE njb-56 15 68 journal journal NOUN njb-56 15 69     SPACE njb-56 15 70 of of ADP njb-56 15 71     SPACE njb-56 15 72 biotechnology biotechnology NOUN njb-56 15 73 . . PUNCT njb-56 15 74     SPACE njb-56 16 1 jan jan PROPN njb-56 16 2 . . PROPN njb-56 16 3     SPACE njb-56 16 4 2011 2011 NUM njb-56 16 5 , , PUNCT njb-56 16 6     SPACE njb-56 16 7 vol vol NOUN njb-56 16 8 . . PUNCT njb-56 16 9     SPACE njb-56 16 10 1 1 NUM njb-56 16 11 , , PUNCT njb-56 16 12     SPACE njb-56 16 13 no no INTJ njb-56 16 14 . . PUNCT njb-56 16 15     SPACE njb-56 17 1 1 1 X njb-56 17 2     SPACE njb-56 17 3 : : PUNCT njb-56 17 4     SPACE njb-56 17 5 14‐21 14‐21 NUM njb-56 17 6     SPACE njb-56 17 7 15 15 NUM njb-56 17 8       SPACE njb-56 17 9 biotechnology biotechnology NOUN njb-56 17 10     SPACE njb-56 17 11 society society NOUN njb-56 17 12     SPACE njb-56 17 13 of of ADP njb-56 17 14     SPACE njb-56 17 15 nepal nepal NOUN njb-56 17 16     SPACE njb-56 17 17 ( ( PUNCT njb-56 17 18 bsn bsn PROPN njb-56 17 19 ) ) PUNCT njb-56 17 20 , , PUNCT njb-56 17 21     SPACE njb-56 17 22 all all DET njb-56 17 23     SPACE njb-56 17 24 rights right NOUN njb-56 17 25     SPACE njb-56 17 26 reserved reserve VERB njb-56 17 27       SPACE njb-56 17 28 ( ( PUNCT njb-56 17 29 240/100,000 240/100,000 NUM njb-56 17 30 ) ) PUNCT njb-56 17 31 . . PUNCT njb-56 17 32     SPACE njb-56 18 1 the the DET njb-56 18 2     SPACE njb-56 18 3 proportion proportion NOUN njb-56 18 4     SPACE njb-56 18 5 of of ADP njb-56 18 6     SPACE njb-56 18 7 mdr‐tb mdr‐tb ADJ njb-56 18 8     SPACE njb-56 18 9 in in ADP njb-56 18 10     SPACE njb-56 18 11 nepal nepal NOUN njb-56 18 12     SPACE njb-56 18 13 was be AUX njb-56 18 14     SPACE njb-56 18 15 2.9 2.9 NUM njb-56 18 16 % % NOUN njb-56 18 17     SPACE njb-56 18 18 ( ( PUNCT njb-56 18 19 95 95 NUM njb-56 18 20 % % NOUN njb-56 18 21     SPACE njb-56 18 22 ci ci PROPN njb-56 18 23 : : PUNCT njb-56 18 24     SPACE njb-56 18 25 1.8‐4.3 1.8‐4.3 NUM njb-56 18 26 ) ) PUNCT njb-56 18 27     SPACE njb-56 18 28 among among ADP njb-56 18 29     SPACE njb-56 18 30 new new ADJ njb-56 18 31     SPACE njb-56 18 32 cases case NOUN njb-56 18 33     SPACE njb-56 18 34 and and CCONJ njb-56 18 35     SPACE njb-56 18 36 11.7 11.7 NUM njb-56 18 37 % % NOUN njb-56 18 38     SPACE njb-56 18 39 ( ( PUNCT njb-56 18 40 95 95 NUM njb-56 18 41 % % NOUN njb-56 18 42     SPACE njb-56 18 43 ci ci PROPN njb-56 18 44 : : PUNCT njb-56 18 45     SPACE njb-56 18 46 7.2‐17.7 7.2‐17.7 NUM njb-56 18 47 ) ) PUNCT njb-56 18 48     SPACE njb-56 18 49 among among ADP njb-56 18 50     SPACE njb-56 18 51 retreatment retreatment NOUN njb-56 18 52     SPACE njb-56 18 53 cases case NOUN njb-56 18 54     SPACE njb-56 18 55 ( ( PUNCT njb-56 18 56 ntc ntc NOUN njb-56 18 57 , , PUNCT njb-56 18 58     SPACE njb-56 18 59 2009 2009 NUM njb-56 18 60 ) ) PUNCT njb-56 18 61 . . PUNCT njb-56 18 62     SPACE njb-56 19 1 in in ADP njb-56 19 2     SPACE njb-56 19 3 2009 2009 NUM njb-56 19 4 , , PUNCT njb-56 19 5     SPACE njb-56 19 6 with with ADP njb-56 19 7     SPACE njb-56 19 8 the the DET njb-56 19 9     SPACE njb-56 19 10 assistance assistance NOUN njb-56 19 11     SPACE njb-56 19 12 of of ADP njb-56 19 13     SPACE njb-56 19 14 who who PRON njb-56 19 15 , , PUNCT njb-56 19 16     SPACE njb-56 19 17 national national PROPN njb-56 19 18     SPACE njb-56 19 19 tb tb PROPN njb-56 19 20     SPACE njb-56 19 21 center center NOUN njb-56 19 22     SPACE njb-56 19 23 in in ADP njb-56 19 24     SPACE njb-56 19 25 collaboration collaboration NOUN njb-56 19 26     SPACE njb-56 19 27 with with ADP njb-56 19 28     SPACE njb-56 19 29 national national ADJ njb-56 19 30     SPACE njb-56 19 31 anti‐tuberculosis anti‐tuberculosis NOUN njb-56 19 32     SPACE njb-56 19 33 association association NOUN njb-56 19 34     SPACE njb-56 19 35 ( ( PUNCT njb-56 19 36 nata nata NOUN njb-56 19 37 ) ) PUNCT njb-56 19 38     SPACE njb-56 19 39 and and CCONJ njb-56 19 40     SPACE njb-56 19 41 german german ADJ njb-56 19 42     SPACE njb-56 19 43 nepal nepal ADJ njb-56 19 44     SPACE njb-56 19 45 tuberculosis tuberculosis NOUN njb-56 19 46     SPACE njb-56 19 47 project project NOUN njb-56 19 48     SPACE njb-56 19 49 ( ( PUNCT njb-56 19 50 gentup gentup PROPN njb-56 19 51 ) ) PUNCT njb-56 19 52     SPACE njb-56 19 53 had have AUX njb-56 19 54     SPACE njb-56 19 55 conducted conduct VERB njb-56 19 56     SPACE njb-56 19 57 a a DET njb-56 19 58     SPACE njb-56 19 59 surveillance surveillance NOUN njb-56 19 60     SPACE njb-56 19 61 of of ADP njb-56 19 62     SPACE njb-56 19 63 extremely extremely ADV njb-56 19 64     SPACE njb-56 19 65 drug‐resistant drug‐resistant NOUN njb-56 19 66     SPACE njb-56 19 67 tuberculosis tuberculosis NOUN njb-56 19 68     SPACE njb-56 19 69 ( ( PUNCT njb-56 19 70 xdr‐tb xdr‐tb PROPN njb-56 19 71 ) ) PUNCT njb-56 19 72     SPACE njb-56 19 73 among among ADP njb-56 19 74     SPACE njb-56 19 75 the the DET njb-56 19 76     SPACE njb-56 19 77 registered register VERB njb-56 19 78     SPACE njb-56 19 79 mdr mdr PROPN njb-56 19 80     SPACE njb-56 19 81 tb tb PROPN njb-56 19 82     SPACE njb-56 19 83 patients patient NOUN njb-56 19 84 . . PUNCT njb-56 19 85     SPACE njb-56 20 1 the the DET njb-56 20 2     SPACE njb-56 20 3 study study NOUN njb-56 20 4     SPACE njb-56 20 5 showed show VERB njb-56 20 6     SPACE njb-56 20 7 a a DET njb-56 20 8     SPACE njb-56 20 9 prevalence prevalence NOUN njb-56 20 10     SPACE njb-56 20 11 of of ADP njb-56 20 12     SPACE njb-56 20 13 5 5 NUM njb-56 20 14 % % NOUN njb-56 20 15     SPACE njb-56 20 16 of of ADP njb-56 20 17     SPACE njb-56 20 18 xdr‐tb xdr‐tb PROPN njb-56 20 19     SPACE njb-56 20 20 cases case NOUN njb-56 20 21     SPACE njb-56 20 22 among among ADP njb-56 20 23     SPACE njb-56 20 24 mdr mdr PROPN njb-56 20 25     SPACE njb-56 20 26 tb tb PROPN njb-56 20 27     SPACE njb-56 20 28 cases case NOUN njb-56 20 29     SPACE njb-56 20 30 registered register VERB njb-56 20 31     SPACE njb-56 20 32 ( ( PUNCT njb-56 20 33 ntc ntc PROPN njb-56 20 34 , , PUNCT njb-56 20 35     SPACE njb-56 20 36 2009 2009 NUM njb-56 20 37 ) ) PUNCT njb-56 20 38 . . PUNCT njb-56 20 39     SPACE njb-56 21 1 isoniazid isoniazid PROPN njb-56 21 2     SPACE njb-56 21 3 ( ( PUNCT njb-56 21 4 inh inh PROPN njb-56 21 5 ) ) PUNCT njb-56 21 6     SPACE njb-56 21 7 is be AUX njb-56 21 8     SPACE njb-56 21 9 one one NUM njb-56 21 10     SPACE njb-56 21 11 of of ADP njb-56 21 12     SPACE njb-56 21 13 the the DET njb-56 21 14     SPACE njb-56 21 15 important important ADJ njb-56 21 16     SPACE njb-56 21 17 first‐line first‐line NOUN njb-56 21 18     SPACE njb-56 21 19 tuberculosis tuberculosis NOUN njb-56 21 20     SPACE njb-56 21 21 drugs drug NOUN njb-56 21 22 . . PUNCT njb-56 21 23     SPACE njb-56 21 24 mtb mtb NOUN njb-56 21 25     SPACE njb-56 21 26 is be AUX njb-56 21 27     SPACE njb-56 21 28 highly highly ADV njb-56 21 29     SPACE njb-56 21 30 susceptible susceptible ADJ njb-56 21 31     SPACE njb-56 21 32 to to ADP njb-56 21 33     SPACE njb-56 21 34 inh inh PROPN njb-56 21 35 , , PUNCT njb-56 21 36     SPACE njb-56 21 37 with with ADP njb-56 21 38     SPACE njb-56 21 39 a a DET njb-56 21 40     SPACE njb-56 21 41 minimum minimum ADJ njb-56 21 42     SPACE njb-56 21 43 inhibitory inhibitory ADJ njb-56 21 44     SPACE njb-56 21 45 concentration concentration NOUN njb-56 21 46     SPACE njb-56 21 47 ( ( PUNCT njb-56 21 48 mic mic NOUN njb-56 21 49 ) ) PUNCT njb-56 21 50     SPACE njb-56 21 51 of of ADP njb-56 21 52     SPACE njb-56 21 53 0.03 0.03 NUM njb-56 21 54 ‐0.06 ‐0.06 PROPN njb-56 21 55     SPACE njb-56 21 56 mg mg PROPN njb-56 21 57     SPACE njb-56 21 58 ml‐1 ml‐1 PROPN njb-56 21 59 . . PUNCT njb-56 21 60     SPACE njb-56 22 1 inh inh PROPN njb-56 22 2     SPACE njb-56 22 3 inhibits inhibit VERB njb-56 22 4     SPACE njb-56 22 5 the the DET njb-56 22 6     SPACE njb-56 22 7 biosynthesis biosynthesis NOUN njb-56 22 8     SPACE njb-56 22 9 of of ADP njb-56 22 10     SPACE njb-56 22 11 cell cell NOUN njb-56 22 12     SPACE njb-56 22 13 wall wall NOUN njb-56 22 14     SPACE njb-56 22 15 mycolic mycolic ADJ njb-56 22 16     SPACE njb-56 22 17 acids acid NOUN njb-56 22 18     SPACE njb-56 22 19 ( ( PUNCT njb-56 22 20 long long ADJ njb-56 22 21     SPACE njb-56 22 22 chain chain NOUN njb-56 22 23     SPACE njb-56 22 24 α‐branched α‐branched PUNCT njb-56 22 25     SPACE njb-56 22 26 ß‐hydroxylated ß‐hydroxylated PUNCT njb-56 22 27     SPACE njb-56 22 28 fatty fatty ADJ njb-56 22 29     SPACE njb-56 22 30 acids acid NOUN njb-56 22 31 ) ) PUNCT njb-56 22 32 , , PUNCT njb-56 22 33     SPACE njb-56 22 34 thereby thereby ADV njb-56 22 35     SPACE njb-56 22 36 making make VERB njb-56 22 37     SPACE njb-56 22 38 the the DET njb-56 22 39     SPACE njb-56 22 40 mycobacteria mycobacterium NOUN njb-56 22 41     SPACE njb-56 22 42 susceptible susceptible ADJ njb-56 22 43     SPACE njb-56 22 44 to to PART njb-56 22 45     SPACE njb-56 22 46 reactive reactive ADJ njb-56 22 47     SPACE njb-56 22 48 oxygen oxygen NOUN njb-56 22 49     SPACE njb-56 22 50 radicals radical NOUN njb-56 22 51     SPACE njb-56 22 52 and and CCONJ njb-56 22 53     SPACE njb-56 22 54 other other ADJ njb-56 22 55     SPACE njb-56 22 56 environmental environmental ADJ njb-56 22 57     SPACE njb-56 22 58 factors factor NOUN njb-56 22 59     SPACE njb-56 22 60 ( ( PUNCT njb-56 22 61 rattan rattan PROPN njb-56 22 62     SPACE njb-56 22 63 et et PROPN njb-56 22 64     SPACE njb-56 22 65 al al PROPN njb-56 22 66 . . PROPN njb-56 22 67 , , PUNCT njb-56 22 68     SPACE njb-56 22 69 1998 1998 NUM njb-56 22 70 ) ) PUNCT njb-56 22 71 . . PUNCT njb-56 22 72     SPACE njb-56 23 1 it it PRON njb-56 23 2     SPACE njb-56 23 3 is be AUX njb-56 23 4     SPACE njb-56 23 5 a a DET njb-56 23 6     SPACE njb-56 23 7 pro‐ pro‐ NOUN njb-56 23 8 drug drug NOUN njb-56 23 9     SPACE njb-56 23 10 that that PRON njb-56 23 11     SPACE njb-56 23 12 requires require VERB njb-56 23 13     SPACE njb-56 23 14 activation activation NOUN njb-56 23 15     SPACE njb-56 23 16 by by ADP njb-56 23 17     SPACE njb-56 23 18 the the DET njb-56 23 19     SPACE njb-56 23 20 mtb mtb NOUN njb-56 23 21     SPACE njb-56 23 22 catalase‐ catalase‐ NOUN njb-56 23 23 peroxidase peroxidase NOUN njb-56 23 24     SPACE njb-56 23 25 enzyme enzyme NOUN njb-56 23 26     SPACE njb-56 23 27 ( ( PUNCT njb-56 23 28 katg katg PROPN njb-56 23 29 ) ) PUNCT njb-56 23 30     SPACE njb-56 23 31 to to ADP njb-56 23 32     SPACE njb-56 23 33 its its PRON njb-56 23 34     SPACE njb-56 23 35 active active ADJ njb-56 23 36     SPACE njb-56 23 37 form form NOUN njb-56 23 38 . . PUNCT njb-56 23 39     SPACE njb-56 23 40 mutation mutation NOUN njb-56 23 41     SPACE njb-56 23 42 of of ADP njb-56 23 43     SPACE njb-56 23 44 the the DET njb-56 23 45     SPACE njb-56 23 46 katg katg PROPN njb-56 23 47     SPACE njb-56 23 48 gene gene NOUN njb-56 23 49 , , PUNCT njb-56 23 50     SPACE njb-56 23 51 which which PRON njb-56 23 52     SPACE njb-56 23 53 leads lead VERB njb-56 23 54     SPACE njb-56 23 55 to to ADP njb-56 23 56     SPACE njb-56 23 57 loss loss NOUN njb-56 23 58     SPACE njb-56 23 59 of of ADP njb-56 23 60     SPACE njb-56 23 61 or or CCONJ njb-56 23 62     SPACE njb-56 23 63 reduced reduce VERB njb-56 23 64     SPACE njb-56 23 65 catalase‐peroxidase catalase‐peroxidase PROPN njb-56 23 66     SPACE njb-56 23 67 activity activity NOUN njb-56 23 68 , , PUNCT njb-56 23 69     SPACE njb-56 23 70 is be AUX njb-56 23 71     SPACE njb-56 23 72 a a DET njb-56 23 73     SPACE njb-56 23 74 major major ADJ njb-56 23 75     SPACE njb-56 23 76 mechanism mechanism NOUN njb-56 23 77     SPACE njb-56 23 78 of of ADP njb-56 23 79     SPACE njb-56 23 80 inh inh PROPN njb-56 23 81     SPACE njb-56 23 82 resistance resistance NOUN njb-56 23 83     SPACE njb-56 23 84 in in ADP njb-56 23 85     SPACE njb-56 23 86 mtb mtb NOUN njb-56 23 87     SPACE njb-56 23 88 ( ( PUNCT njb-56 23 89 musser musser PROPN njb-56 23 90 , , PUNCT njb-56 23 91     SPACE njb-56 23 92 1995 1995 NUM njb-56 23 93 ) ) PUNCT njb-56 23 94 . . PUNCT njb-56 23 95     SPACE njb-56 24 1 although although SCONJ njb-56 24 2     SPACE njb-56 24 3 various various ADJ njb-56 24 4     SPACE njb-56 24 5 mutations mutation NOUN njb-56 24 6     SPACE njb-56 24 7 in in ADP njb-56 24 8     SPACE njb-56 24 9 the the DET njb-56 24 10     SPACE njb-56 24 11 katg katg PROPN njb-56 24 12     SPACE njb-56 24 13 gene gene NOUN njb-56 24 14     SPACE njb-56 24 15 have have AUX njb-56 24 16     SPACE njb-56 24 17 been be AUX njb-56 24 18     SPACE njb-56 24 19 reported report VERB njb-56 24 20     SPACE njb-56 24 21 in in ADP njb-56 24 22     SPACE njb-56 24 23 inh‐resistant inh‐resistant NOUN njb-56 24 24     SPACE njb-56 24 25 isolates isolate NOUN njb-56 24 26 , , PUNCT njb-56 24 27     SPACE njb-56 24 28 the the DET njb-56 24 29     SPACE njb-56 24 30 most most ADJ njb-56 24 31     SPACE njb-56 24 32 common common ADJ njb-56 24 33     SPACE njb-56 24 34 mutation mutation NOUN njb-56 24 35     SPACE njb-56 24 36 is be AUX njb-56 24 37     SPACE njb-56 24 38 the the DET njb-56 24 39     SPACE njb-56 24 40 ser315thr ser315thr NOUN njb-56 24 41     SPACE njb-56 24 42 mutation mutation NOUN njb-56 24 43 , , PUNCT njb-56 24 44     SPACE njb-56 24 45 which which PRON njb-56 24 46     SPACE njb-56 24 47 is be AUX njb-56 24 48     SPACE njb-56 24 49 present present ADJ njb-56 24 50     SPACE njb-56 24 51 in in ADP njb-56 24 52     SPACE njb-56 24 53 approximately approximately ADV njb-56 24 54     SPACE njb-56 24 55 50–90 50–90 NUM njb-56 24 56 % % NOUN njb-56 24 57     SPACE njb-56 24 58 of of ADP njb-56 24 59     SPACE njb-56 24 60 all all PRON njb-56 24 61     SPACE njb-56 24 62 inh‐resistant inh‐resistant ADJ njb-56 24 63     SPACE njb-56 24 64 isolates isolate NOUN njb-56 24 65 , , PUNCT njb-56 24 66     SPACE njb-56 24 67 is be AUX njb-56 24 68     SPACE njb-56 24 69 associated associate VERB njb-56 24 70     SPACE njb-56 24 71 with with ADP njb-56 24 72     SPACE njb-56 24 73 relatively relatively ADV njb-56 24 74     SPACE njb-56 24 75 high‐level high‐level NOUN njb-56 24 76     SPACE njb-56 24 77 resistance resistance NOUN njb-56 24 78     SPACE njb-56 24 79 to to ADP njb-56 24 80     SPACE njb-56 24 81 inh inh PROPN njb-56 24 82     SPACE njb-56 24 83 ( ( PUNCT njb-56 24 84 mokrousov mokrousov PROPN njb-56 24 85     SPACE njb-56 24 86 et et PROPN njb-56 24 87     SPACE njb-56 24 88 al al PROPN njb-56 24 89 . . PROPN njb-56 24 90 , , PUNCT njb-56 24 91     SPACE njb-56 24 92 2002 2002 NUM njb-56 24 93 ) ) PUNCT njb-56 24 94 . . PUNCT njb-56 24 95       SPACE njb-56 25 1 more more ADJ njb-56 25 2     SPACE njb-56 25 3 than than ADP njb-56 25 4     SPACE njb-56 25 5 one‐third one‐third NOUN njb-56 25 6     SPACE njb-56 25 7 of of ADP njb-56 25 8     SPACE njb-56 25 9 the the DET njb-56 25 10     SPACE njb-56 25 11 global global ADJ njb-56 25 12     SPACE njb-56 25 13 population population NOUN njb-56 25 14     SPACE njb-56 25 15 is be AUX njb-56 25 16     SPACE njb-56 25 17 infected infect VERB njb-56 25 18     SPACE njb-56 25 19 with with ADP njb-56 25 20     SPACE njb-56 25 21 mtb mtb NOUN njb-56 25 22 . . PUNCT njb-56 25 23     SPACE njb-56 25 24 however however ADV njb-56 25 25 , , PUNCT njb-56 25 26     SPACE njb-56 25 27 only only ADV njb-56 25 28     SPACE njb-56 25 29 10 10 NUM njb-56 25 30 % % NOUN njb-56 25 31     SPACE njb-56 25 32 develop develop VERB njb-56 25 33     SPACE njb-56 25 34 the the DET njb-56 25 35     SPACE njb-56 25 36 clinical clinical ADJ njb-56 25 37     SPACE njb-56 25 38 disease disease NOUN njb-56 25 39 . . PUNCT njb-56 25 40     SPACE njb-56 26 1 many many ADJ njb-56 26 2     SPACE njb-56 26 3 factors factor NOUN njb-56 26 4     SPACE njb-56 26 5 contribute contribute VERB njb-56 26 6     SPACE njb-56 26 7 to to ADP njb-56 26 8     SPACE njb-56 26 9 the the DET njb-56 26 10     SPACE njb-56 26 11 immune immune ADJ njb-56 26 12     SPACE njb-56 26 13 response response NOUN njb-56 26 14     SPACE njb-56 26 15 against against ADP njb-56 26 16     SPACE njb-56 26 17 tuberculosis tuberculosis NOUN njb-56 26 18 . . PUNCT njb-56 26 19     SPACE njb-56 27 1 the the DET njb-56 27 2     SPACE njb-56 27 3 solute solute ADJ njb-56 27 4     SPACE njb-56 27 5 carrier carrier NOUN njb-56 27 6     SPACE njb-56 27 7 family family NOUN njb-56 27 8     SPACE njb-56 27 9 11 11 NUM njb-56 27 10     SPACE njb-56 27 11 member member NOUN njb-56 27 12     SPACE njb-56 27 13 1 1 NUM njb-56 27 14     SPACE njb-56 27 15 gene gene NOUN njb-56 27 16     SPACE njb-56 27 17 ( ( PUNCT njb-56 27 18 slc11a1 slc11a1 ADV njb-56 27 19 , , PUNCT njb-56 27 20     SPACE njb-56 27 21 formerly formerly ADV njb-56 27 22     SPACE njb-56 27 23 known know VERB njb-56 27 24     SPACE njb-56 27 25 as as ADV njb-56 27 26     SPACE njb-56 27 27 nramp1 nramp1 NOUN njb-56 27 28 : : PUNCT njb-56 27 29     SPACE njb-56 27 30 natural natural ADJ njb-56 27 31     SPACE njb-56 27 32 resistance resistance NOUN njb-56 27 33     SPACE njb-56 27 34 associated associate VERB njb-56 27 35     SPACE njb-56 27 36 macrophage macrophage NOUN njb-56 27 37     SPACE njb-56 27 38 protein protein NOUN njb-56 27 39     SPACE njb-56 27 40 1 1 NUM njb-56 27 41 ) ) PUNCT njb-56 27 42     SPACE njb-56 27 43 is be AUX njb-56 27 44     SPACE njb-56 27 45 one one NOUN njb-56 27 46     SPACE njb-56 27 47 of of ADP njb-56 27 48     SPACE njb-56 27 49 the the DET njb-56 27 50     SPACE njb-56 27 51 candidate candidate NOUN njb-56 27 52     SPACE njb-56 27 53 genes gene NOUN njb-56 27 54     SPACE njb-56 27 55 for for ADP njb-56 27 56     SPACE njb-56 27 57 susceptibility susceptibility NOUN njb-56 27 58     SPACE njb-56 27 59 to to ADP njb-56 27 60     SPACE njb-56 27 61 human human NOUN njb-56 27 62     SPACE njb-56 27 63 tuberculosis tuberculosis NOUN njb-56 27 64     SPACE njb-56 27 65 ( ( PUNCT njb-56 27 66 takahashi takahashi PROPN njb-56 27 67     SPACE njb-56 27 68 et et PROPN njb-56 27 69     SPACE njb-56 27 70 al al PROPN njb-56 27 71 . . PROPN njb-56 27 72 , , PUNCT njb-56 27 73     SPACE njb-56 27 74 2008 2008 NUM njb-56 27 75 ) ) PUNCT njb-56 27 76 . . PUNCT njb-56 27 77     SPACE njb-56 28 1 the the DET njb-56 28 2     SPACE njb-56 28 3 gene gene NOUN njb-56 28 4     SPACE njb-56 28 5 is be AUX njb-56 28 6     SPACE njb-56 28 7 located locate VERB njb-56 28 8     SPACE njb-56 28 9 on on ADP njb-56 28 10     SPACE njb-56 28 11 human human NOUN njb-56 28 12     SPACE njb-56 28 13 chromosome chromosome NOUN njb-56 28 14     SPACE njb-56 28 15 2q35 2q35 NUM njb-56 28 16     SPACE njb-56 28 17 and and CCONJ njb-56 28 18     SPACE njb-56 28 19 has have VERB njb-56 28 20     SPACE njb-56 28 21 15 15 NUM njb-56 28 22     SPACE njb-56 28 23 exons exon NOUN njb-56 28 24     SPACE njb-56 28 25 spanning span VERB njb-56 28 26     SPACE njb-56 28 27 about about ADV njb-56 28 28     SPACE njb-56 28 29 14 14 NUM njb-56 28 30     SPACE njb-56 28 31 kb kb PROPN njb-56 28 32     SPACE njb-56 28 33 ( ( PUNCT njb-56 28 34 marquet marquet PROPN njb-56 28 35     SPACE njb-56 28 36 et et PROPN njb-56 28 37     SPACE njb-56 28 38 al al PROPN njb-56 28 39 . . PROPN njb-56 28 40 , , PUNCT njb-56 28 41     SPACE njb-56 28 42 2000 2000 NUM njb-56 28 43 ) ) PUNCT njb-56 28 44 . . PUNCT njb-56 28 45     SPACE njb-56 29 1 the the DET njb-56 29 2     SPACE njb-56 29 3 gene gene NOUN njb-56 29 4     SPACE njb-56 29 5 encodes encode VERB njb-56 29 6     SPACE njb-56 29 7 a a DET njb-56 29 8     SPACE njb-56 29 9 transmembrane transmembrane NOUN njb-56 29 10     SPACE njb-56 29 11 protein protein NOUN njb-56 29 12     SPACE njb-56 29 13 expressed express VERB njb-56 29 14     SPACE njb-56 29 15 exclusively exclusively ADV njb-56 29 16     SPACE njb-56 29 17 in in ADP njb-56 29 18     SPACE njb-56 29 19 macrophages/ macrophages/ PROPN njb-56 29 20 monocytes monocyte NOUN njb-56 29 21     SPACE njb-56 29 22 and and CCONJ njb-56 29 23     SPACE njb-56 29 24 polymorphonuclear polymorphonuclear ADJ njb-56 29 25     SPACE njb-56 29 26 leukocytes leukocyte NOUN njb-56 29 27 . . PUNCT njb-56 29 28     SPACE njb-56 30 1 the the DET njb-56 30 2     SPACE njb-56 30 3 protein protein NOUN njb-56 30 4     SPACE njb-56 30 5 acts act VERB njb-56 30 6     SPACE njb-56 30 7 as as ADP njb-56 30 8     SPACE njb-56 30 9 a a DET njb-56 30 10     SPACE njb-56 30 11 transporter transporter NOUN njb-56 30 12     SPACE njb-56 30 13 for for ADP njb-56 30 14     SPACE njb-56 30 15 divalent divalent ADJ njb-56 30 16     SPACE njb-56 30 17 cations cation NOUN njb-56 30 18     SPACE njb-56 30 19 fe2 fe2 PROPN njb-56 30 20 + + PROPN njb-56 30 21 , , PUNCT njb-56 30 22     SPACE njb-56 30 23 zn2 zn2 PROPN njb-56 30 24 + + SYM njb-56 30 25     SPACE njb-56 30 26 and and CCONJ njb-56 30 27     SPACE njb-56 30 28 mn2 mn2 VERB njb-56 31 1 + + NOUN njb-56 31 2     SPACE njb-56 31 3 and and CCONJ njb-56 31 4     SPACE njb-56 31 5 has have VERB njb-56 31 6     SPACE njb-56 31 7 pleiotropic pleiotropic ADJ njb-56 31 8     SPACE njb-56 31 9 effects effect NOUN njb-56 31 10     SPACE njb-56 31 11 on on ADP njb-56 31 12     SPACE njb-56 31 13 macrophage macrophage NOUN njb-56 31 14     SPACE njb-56 31 15 activation activation NOUN njb-56 31 16     SPACE njb-56 31 17 ( ( PUNCT njb-56 31 18 goswami goswami PROPN njb-56 31 19     SPACE njb-56 31 20 et et PROPN njb-56 31 21     SPACE njb-56 31 22 al al PROPN njb-56 31 23 . . PROPN njb-56 31 24 , , PUNCT njb-56 31 25     SPACE njb-56 31 26 2001 2001 NUM njb-56 31 27 ) ) PUNCT njb-56 31 28 . . PUNCT njb-56 31 29       SPACE njb-56 32 1 studies study NOUN njb-56 32 2     SPACE njb-56 32 3 have have AUX njb-56 32 4     SPACE njb-56 32 5 demonstrated demonstrate VERB njb-56 32 6     SPACE njb-56 32 7 an an DET njb-56 32 8     SPACE njb-56 32 9 association association NOUN njb-56 32 10     SPACE njb-56 32 11 between between ADP njb-56 32 12     SPACE njb-56 32 13 three three NUM njb-56 32 14     SPACE njb-56 32 15 different different ADJ njb-56 32 16     SPACE njb-56 32 17 polymorphisms polymorphism NOUN njb-56 32 18     SPACE njb-56 32 19 ( ( PUNCT njb-56 32 20 int4 int4 PROPN njb-56 32 21 , , PUNCT njb-56 32 22     SPACE njb-56 32 23 d543n d543n PROPN njb-56 32 24     SPACE njb-56 32 25 and and CCONJ njb-56 32 26     SPACE njb-56 32 27 3’utr 3’utr NUM njb-56 32 28 ) ) PUNCT njb-56 32 29     SPACE njb-56 32 30 in in ADP njb-56 32 31     SPACE njb-56 32 32 slc11a1 slc11a1 NOUN njb-56 32 33     SPACE njb-56 32 34 and and CCONJ njb-56 32 35     SPACE njb-56 32 36 pulmonary pulmonary ADJ njb-56 32 37     SPACE njb-56 32 38 tb tb NOUN njb-56 32 39     SPACE njb-56 32 40 ( ( PUNCT njb-56 32 41 taype taype NOUN njb-56 32 42     SPACE njb-56 32 43 et et NOUN njb-56 32 44     SPACE njb-56 32 45 al al PROPN njb-56 32 46 . . PROPN njb-56 32 47 , , PUNCT njb-56 32 48     SPACE njb-56 32 49 2006 2006 NUM njb-56 32 50 ) ) PUNCT njb-56 32 51 . . PUNCT njb-56 32 52     SPACE njb-56 33 1 in in ADP njb-56 33 2     SPACE njb-56 33 3 the the DET njb-56 33 4     SPACE njb-56 33 5 present present ADJ njb-56 33 6     SPACE njb-56 33 7 study study NOUN njb-56 33 8 , , PUNCT njb-56 33 9     SPACE njb-56 33 10 ser315thr ser315thr NOUN njb-56 33 11     SPACE njb-56 33 12 katg katg PROPN njb-56 33 13     SPACE njb-56 33 14 mutation mutation NOUN njb-56 33 15     SPACE njb-56 33 16 in in ADP njb-56 33 17     SPACE njb-56 33 18 the the DET njb-56 33 19     SPACE njb-56 33 20 mdr‐tb mdr‐tb ADJ njb-56 33 21     SPACE njb-56 33 22 culture culture NOUN njb-56 33 23     SPACE njb-56 33 24 samples sample NOUN njb-56 33 25     SPACE njb-56 33 26 and and CCONJ njb-56 33 27     SPACE njb-56 33 28 g g X njb-56 33 29 / / SYM njb-56 33 30 c c NOUN njb-56 33 31     SPACE njb-56 33 32 polymorphisms polymorphism NOUN njb-56 33 33     SPACE njb-56 33 34 in in ADP njb-56 33 35     SPACE njb-56 33 36 int4 int4 PROPN njb-56 33 37     SPACE njb-56 33 38 region region NOUN njb-56 33 39     SPACE njb-56 33 40 of of ADP njb-56 33 41     SPACE njb-56 33 42 slc11a1 slc11a1 NOUN njb-56 33 43     SPACE njb-56 33 44 of of ADP njb-56 33 45     SPACE njb-56 33 46 tb tb PROPN njb-56 33 47     SPACE njb-56 33 48 patients patient NOUN njb-56 33 49     SPACE njb-56 33 50 were be AUX njb-56 33 51     SPACE njb-56 33 52 studied study VERB njb-56 33 53     SPACE njb-56 33 54 using use VERB njb-56 33 55     SPACE njb-56 33 56 polymerase polymerase NOUN njb-56 33 57     SPACE njb-56 33 58 chain chain NOUN njb-56 33 59     SPACE njb-56 33 60 reaction reaction NOUN njb-56 33 61     SPACE njb-56 33 62 ( ( PUNCT njb-56 33 63 pcr pcr PROPN njb-56 33 64 ) ) PUNCT njb-56 33 65     SPACE njb-56 33 66 ‐ ‐ AUX njb-56 33 67     SPACE njb-56 33 68 restriction restriction NOUN njb-56 33 69     SPACE njb-56 33 70 fragment fragment ADJ njb-56 33 71     SPACE njb-56 33 72 length length NOUN njb-56 33 73     SPACE njb-56 33 74 polymorphism polymorphism NOUN njb-56 33 75     SPACE njb-56 33 76 ( ( PUNCT njb-56 33 77 rflp rflp NOUN njb-56 33 78 ) ) PUNCT njb-56 33 79     SPACE njb-56 33 80 technique technique NOUN njb-56 33 81 . . PUNCT njb-56 33 82     SPACE njb-56 34 1 materials material NOUN njb-56 34 2     SPACE njb-56 34 3 and and CCONJ njb-56 34 4     SPACE njb-56 34 5 methods method NOUN njb-56 34 6     SPACE njb-56 34 7 study study NOUN njb-56 34 8     SPACE njb-56 34 9 samples sample NOUN njb-56 34 10 . . PUNCT njb-56 34 11     SPACE njb-56 35 1 24 24 NUM njb-56 35 2     SPACE njb-56 35 3 mtb mtb NOUN njb-56 35 4     SPACE njb-56 35 5 culture culture NOUN njb-56 35 6     SPACE njb-56 35 7 ( ( PUNCT njb-56 35 8 all all PRON njb-56 35 9     SPACE njb-56 35 10 afb afb VERB njb-56 35 11     SPACE njb-56 35 12 stain stain NOUN njb-56 35 13     SPACE njb-56 35 14 positive positive ADJ njb-56 35 15 ) ) PUNCT njb-56 35 16     SPACE njb-56 35 17 samples sample NOUN njb-56 35 18     SPACE njb-56 35 19 were be AUX njb-56 35 20     SPACE njb-56 35 21 obtained obtain VERB njb-56 35 22     SPACE njb-56 35 23 from from ADP njb-56 35 24     SPACE njb-56 35 25 gentup gentup PROPN njb-56 35 26 , , PUNCT njb-56 35 27     SPACE njb-56 35 28 kathmandu kathmandu NOUN njb-56 35 29 . . PUNCT njb-56 35 30     SPACE njb-56 36 1 the the DET njb-56 36 2     SPACE njb-56 36 3 cultured cultured ADJ njb-56 36 4     SPACE njb-56 36 5 samples sample NOUN njb-56 36 6     SPACE njb-56 36 7 comprised comprise VERB njb-56 36 8     SPACE njb-56 36 9 of of ADP njb-56 36 10     SPACE njb-56 36 11 both both DET njb-56 36 12     SPACE njb-56 36 13 pulmonary pulmonary NOUN njb-56 36 14     SPACE njb-56 36 15 and and CCONJ njb-56 36 16     SPACE njb-56 36 17 extra‐pulmonary extra‐pulmonary PROPN njb-56 36 18     SPACE njb-56 36 19 origin origin NOUN njb-56 36 20 . . PUNCT njb-56 36 21     SPACE njb-56 36 22 drug drug NOUN njb-56 36 23     SPACE njb-56 36 24 susceptibility susceptibility NOUN njb-56 36 25     SPACE njb-56 36 26 testing testing NOUN njb-56 36 27     SPACE njb-56 36 28 was be AUX njb-56 36 29     SPACE njb-56 36 30 also also ADV njb-56 36 31     SPACE njb-56 36 32 carried carry VERB njb-56 36 33     SPACE njb-56 36 34 out out ADP njb-56 36 35     SPACE njb-56 36 36 in in ADP njb-56 36 37     SPACE njb-56 36 38 gentup gentup PROPN njb-56 36 39     SPACE njb-56 36 40 and and CCONJ njb-56 36 41     SPACE njb-56 36 42 all all PRON njb-56 36 43     SPACE njb-56 36 44 of of ADP njb-56 36 45     SPACE njb-56 36 46 the the DET njb-56 36 47     SPACE njb-56 36 48 24 24 NUM njb-56 36 49     SPACE njb-56 36 50 samples sample NOUN njb-56 36 51     SPACE njb-56 36 52 were be AUX njb-56 36 53     SPACE njb-56 36 54 graded grade VERB njb-56 36 55     SPACE njb-56 36 56 as as ADV njb-56 36 57     SPACE njb-56 36 58 mdr‐tb mdr‐tb ADJ njb-56 36 59 . . PUNCT njb-56 36 60     SPACE njb-56 36 61 24 24 NUM njb-56 36 62     SPACE njb-56 36 63 whole whole ADJ njb-56 36 64     SPACE njb-56 36 65 blood blood NOUN njb-56 36 66     SPACE njb-56 36 67 samples sample NOUN njb-56 36 68     SPACE njb-56 36 69 of of ADP njb-56 36 70     SPACE njb-56 36 71 mdr‐tb mdr‐tb ADJ njb-56 36 72     SPACE njb-56 36 73 patients patient NOUN njb-56 36 74     SPACE njb-56 36 75 were be AUX njb-56 36 76     SPACE njb-56 36 77 also also ADV njb-56 36 78     SPACE njb-56 36 79 obtained obtain VERB njb-56 36 80     SPACE njb-56 36 81 for for ADP njb-56 36 82     SPACE njb-56 36 83 slc11a1 slc11a1 NOUN njb-56 36 84     SPACE njb-56 36 85 analysis analysis NOUN njb-56 36 86 . . PUNCT njb-56 36 87     SPACE njb-56 37 1 the the DET njb-56 37 2     SPACE njb-56 37 3 samples sample NOUN njb-56 37 4     SPACE njb-56 37 5 were be AUX njb-56 37 6     SPACE njb-56 37 7 collected collect VERB njb-56 37 8     SPACE njb-56 37 9 from from ADP njb-56 37 10     SPACE njb-56 37 11 the the DET njb-56 37 12     SPACE njb-56 37 13 central central ADJ njb-56 37 14     SPACE njb-56 37 15 development development NOUN njb-56 37 16     SPACE njb-56 37 17 region region NOUN njb-56 37 18     SPACE njb-56 37 19 of of ADP njb-56 37 20     SPACE njb-56 37 21 nepal nepal ADJ njb-56 37 22 . . PUNCT njb-56 37 23     SPACE njb-56 37 24 however however ADV njb-56 37 25 , , PUNCT njb-56 37 26     SPACE njb-56 37 27 we we PRON njb-56 37 28     SPACE njb-56 37 29 were be AUX njb-56 37 30     SPACE njb-56 37 31 unable unable ADJ njb-56 37 32     SPACE njb-56 37 33 to to PART njb-56 37 34     SPACE njb-56 37 35 obtain obtain VERB njb-56 37 36     SPACE njb-56 37 37 the the DET njb-56 37 38     SPACE njb-56 37 39 clinical clinical ADJ njb-56 37 40     SPACE njb-56 37 41 history history NOUN njb-56 37 42     SPACE njb-56 37 43 of of ADP njb-56 37 44     SPACE njb-56 37 45 the the DET njb-56 37 46     SPACE njb-56 37 47 test test NOUN njb-56 37 48     SPACE njb-56 37 49 subjects subject NOUN njb-56 37 50 . . PUNCT njb-56 37 51     SPACE njb-56 38 1 further far ADV njb-56 38 2     SPACE njb-56 38 3 molecular molecular ADJ njb-56 38 4     SPACE njb-56 38 5 analysis analysis NOUN njb-56 38 6     SPACE njb-56 38 7 was be AUX njb-56 38 8     SPACE njb-56 38 9 carried carry VERB njb-56 38 10     SPACE njb-56 38 11 out out ADP njb-56 38 12     SPACE njb-56 38 13 in in ADP njb-56 38 14     SPACE njb-56 38 15 a a DET njb-56 38 16     SPACE njb-56 38 17 bsl‐iii bsl‐iii PROPN njb-56 38 18     SPACE njb-56 38 19 laboratory laboratory NOUN njb-56 38 20     SPACE njb-56 38 21 at at ADP njb-56 38 22     SPACE njb-56 38 23 genetics genetic NOUN njb-56 38 24     SPACE njb-56 38 25 nepal nepal ADJ njb-56 38 26     SPACE njb-56 38 27 pvt pvt PROPN njb-56 38 28 . . PUNCT njb-56 38 29     SPACE njb-56 38 30 ltd ltd PROPN njb-56 38 31 . . PROPN njb-56 38 32 , , PUNCT njb-56 38 33     SPACE njb-56 38 34 lalitpur lalitpur PROPN njb-56 38 35 , , PUNCT njb-56 38 36     SPACE njb-56 38 37 nepal nepal ADJ njb-56 38 38 . . PUNCT njb-56 38 39     SPACE njb-56 38 40 genomic genomic PROPN njb-56 38 41     SPACE njb-56 38 42 dna dna PROPN njb-56 38 43     SPACE njb-56 38 44 isolation isolation NOUN njb-56 38 45     SPACE njb-56 38 46 of of ADP njb-56 38 47     SPACE njb-56 38 48 m. m. NOUN njb-56 38 49     SPACE njb-56 38 50 tuberculosis tuberculosis NOUN njb-56 38 51 . . PUNCT njb-56 38 52     SPACE njb-56 39 1 dna dna PROPN njb-56 39 2     SPACE njb-56 39 3 isolation isolation NOUN njb-56 39 4     SPACE njb-56 39 5 from from ADP njb-56 39 6     SPACE njb-56 39 7 cultured cultured ADJ njb-56 39 8     SPACE njb-56 39 9 samples sample NOUN njb-56 39 10     SPACE njb-56 39 11 was be AUX njb-56 39 12     SPACE njb-56 39 13 done do VERB njb-56 39 14     SPACE njb-56 39 15 using use VERB njb-56 39 16     SPACE njb-56 39 17 sorpo sorpo NOUN njb-56 39 18     SPACE njb-56 39 19 clean clean ADJ njb-56 39 20 ™ ™ ADJ njb-56 39 21     SPACE njb-56 39 22 genomic genomic ADJ njb-56 39 23     SPACE njb-56 39 24 dna dna PROPN njb-56 39 25     SPACE njb-56 39 26 extraction extraction NOUN njb-56 39 27     SPACE njb-56 39 28 kit kit NOUN njb-56 39 29 . . PUNCT njb-56 39 30     SPACE njb-56 40 1 a a DET njb-56 40 2     SPACE njb-56 40 3 loop loop NOUN njb-56 40 4     SPACE njb-56 40 5 full full ADJ njb-56 40 6     SPACE njb-56 40 7 of of ADP njb-56 40 8     SPACE njb-56 40 9 bacterial bacterial ADJ njb-56 40 10     SPACE njb-56 40 11 colonies colony NOUN njb-56 40 12     SPACE njb-56 40 13 from from ADP njb-56 40 14     SPACE njb-56 40 15 the the DET njb-56 40 16     SPACE njb-56 40 17 culture culture NOUN njb-56 40 18     SPACE njb-56 40 19 samples sample NOUN njb-56 40 20     SPACE njb-56 40 21 were be AUX njb-56 40 22     SPACE njb-56 40 23 suspended suspend VERB njb-56 40 24     SPACE njb-56 40 25 in in ADP njb-56 40 26     SPACE njb-56 40 27 200µl 200µl PROPN njb-56 40 28     SPACE njb-56 40 29 of of ADP njb-56 40 30     SPACE njb-56 40 31 sterile sterile ADJ njb-56 40 32     SPACE njb-56 40 33 water water NOUN njb-56 40 34 . . PUNCT njb-56 40 35     SPACE njb-56 41 1 a a DET njb-56 41 2     SPACE njb-56 41 3 spin spin NOUN njb-56 41 4     SPACE njb-56 41 5 column column NOUN njb-56 41 6     SPACE njb-56 41 7 extraction extraction NOUN njb-56 41 8     SPACE njb-56 41 9 was be AUX njb-56 41 10     SPACE njb-56 41 11 carried carry VERB njb-56 41 12     SPACE njb-56 41 13 out out ADP njb-56 41 14     SPACE njb-56 41 15 as as ADP njb-56 41 16     SPACE njb-56 41 17 prescribed prescribe VERB njb-56 41 18     SPACE njb-56 41 19 by by ADP njb-56 41 20     SPACE njb-56 41 21 the the DET njb-56 41 22     SPACE njb-56 41 23 manufacturer manufacturer NOUN njb-56 41 24 . . PUNCT njb-56 41 25     SPACE njb-56 42 1 human human ADJ njb-56 42 2     SPACE njb-56 42 3 genomic genomic PROPN njb-56 42 4     SPACE njb-56 42 5 dna dna PROPN njb-56 42 6     SPACE njb-56 42 7 isolation isolation NOUN njb-56 42 8 . . PUNCT njb-56 42 9     SPACE njb-56 43 1 the the DET njb-56 43 2     SPACE njb-56 43 3 whole‐blood whole‐blood NOUN njb-56 43 4     SPACE njb-56 43 5 samples sample NOUN njb-56 43 6     SPACE njb-56 43 7 from from ADP njb-56 43 8     SPACE njb-56 43 9 human human NOUN njb-56 43 10     SPACE njb-56 43 11 test test NOUN njb-56 43 12     SPACE njb-56 43 13 subjects subject NOUN njb-56 43 14     SPACE njb-56 43 15 were be AUX njb-56 43 16     SPACE njb-56 43 17 collected collect VERB njb-56 43 18     SPACE njb-56 43 19 in in ADP njb-56 43 20     SPACE njb-56 43 21 edta edta NOUN njb-56 43 22     SPACE njb-56 43 23 coated coat VERB njb-56 43 24     SPACE njb-56 43 25 vial vial NOUN njb-56 43 26     SPACE njb-56 43 27 and and CCONJ njb-56 43 28     SPACE njb-56 43 29 immediately immediately ADV njb-56 43 30     SPACE njb-56 43 31 centrifuged centrifuge VERB njb-56 43 32     SPACE njb-56 43 33 at at ADP njb-56 43 34     SPACE njb-56 43 35 5000rpm/5min 5000rpm/5min NUM njb-56 43 36 . . PUNCT njb-56 43 37     SPACE njb-56 44 1 plasma plasma NOUN njb-56 44 2     SPACE njb-56 44 3 was be AUX njb-56 44 4     SPACE njb-56 44 5 separated separate VERB njb-56 44 6     SPACE njb-56 44 7 and and CCONJ njb-56 44 8     SPACE njb-56 44 9 200µl 200µl PROPN njb-56 44 10     SPACE njb-56 44 11 of of ADP njb-56 44 12     SPACE njb-56 44 13 figure figure NOUN njb-56 44 14     SPACE njb-56 44 15 1 1 NUM njb-56 44 16 : : PUNCT njb-56 44 17     SPACE njb-56 44 18 prevalence prevalence NOUN njb-56 44 19     SPACE njb-56 44 20 of of ADP njb-56 44 21     SPACE njb-56 44 22 mdr‐tb mdr‐tb ADJ njb-56 44 23     SPACE njb-56 44 24 in in ADP njb-56 44 25     SPACE njb-56 44 26 nepal nepal ADJ njb-56 44 27 . . PUNCT njb-56 44 28       SPACE njb-56 45 1 ( ( PUNCT njb-56 45 2 source source NOUN njb-56 45 3 : : PUNCT njb-56 45 4     SPACE njb-56 45 5 ntc ntc PROPN njb-56 45 6 , , PUNCT njb-56 45 7     SPACE njb-56 45 8 2009 2009 NUM njb-56 45 9 ) ) PUNCT njb-56 45 10     SPACE njb-56 45 11 nepal nepal ADJ njb-56 45 12     SPACE njb-56 45 13 journal journal NOUN njb-56 45 14     SPACE njb-56 45 15 of of ADP njb-56 45 16     SPACE njb-56 45 17 biotechnology biotechnology NOUN njb-56 45 18 . . PUNCT njb-56 45 19     SPACE njb-56 46 1 jan jan PROPN njb-56 46 2 . . PROPN njb-56 46 3     SPACE njb-56 46 4 2011 2011 NUM njb-56 46 5 , , PUNCT njb-56 46 6     SPACE njb-56 46 7 vol vol NOUN njb-56 46 8 . . PUNCT njb-56 46 9     SPACE njb-56 46 10 1 1 NUM njb-56 46 11 , , PUNCT njb-56 46 12     SPACE njb-56 46 13 no no INTJ njb-56 46 14 . . PUNCT njb-56 46 15     SPACE njb-56 47 1 1 1 X njb-56 47 2     SPACE njb-56 47 3 : : PUNCT njb-56 47 4     SPACE njb-56 47 5 14‐21 14‐21 NUM njb-56 47 6     SPACE njb-56 47 7 16 16 NUM njb-56 47 8       SPACE njb-56 47 9 biotechnology biotechnology NOUN njb-56 47 10     SPACE njb-56 47 11 society society NOUN njb-56 47 12     SPACE njb-56 47 13 of of ADP njb-56 47 14     SPACE njb-56 47 15 nepal nepal NOUN njb-56 47 16     SPACE njb-56 47 17 ( ( PUNCT njb-56 47 18 bsn bsn PROPN njb-56 47 19 ) ) PUNCT njb-56 47 20 , , PUNCT njb-56 47 21     SPACE njb-56 47 22 all all DET njb-56 47 23     SPACE njb-56 47 24 rights right NOUN njb-56 47 25     SPACE njb-56 47 26 reserved reserve VERB njb-56 47 27       SPACE njb-56 47 28 whole‐blood whole‐blood PROPN njb-56 47 29     SPACE njb-56 47 30 was be AUX njb-56 47 31     SPACE njb-56 47 32 taken take VERB njb-56 47 33     SPACE njb-56 47 34 as as ADP njb-56 47 35     SPACE njb-56 47 36 sample sample NOUN njb-56 47 37     SPACE njb-56 47 38 for for ADP njb-56 47 39     SPACE njb-56 47 40 further further ADJ njb-56 47 41     SPACE njb-56 47 42 processing processing NOUN njb-56 47 43 . . PUNCT njb-56 47 44     SPACE njb-56 48 1 sorpo sorpo NOUN njb-56 48 2     SPACE njb-56 48 3 clean clean ADJ njb-56 48 4 ™ ™ ADJ njb-56 48 5     SPACE njb-56 48 6 genomic genomic ADJ njb-56 48 7     SPACE njb-56 48 8 dna dna PROPN njb-56 48 9     SPACE njb-56 48 10 extraction extraction NOUN njb-56 48 11     SPACE njb-56 48 12 kit kit NOUN njb-56 48 13     SPACE njb-56 48 14 was be AUX njb-56 48 15     SPACE njb-56 48 16 used use VERB njb-56 48 17     SPACE njb-56 48 18 for for ADP njb-56 48 19     SPACE njb-56 48 20 genomic genomic ADJ njb-56 48 21     SPACE njb-56 48 22 dna dna PROPN njb-56 48 23     SPACE njb-56 48 24 isolation isolation NOUN njb-56 48 25 . . PUNCT njb-56 48 26     SPACE njb-56 48 27 all all DET njb-56 48 28     SPACE njb-56 48 29 the the DET njb-56 48 30     SPACE njb-56 48 31 other other ADJ njb-56 48 32     SPACE njb-56 48 33 steps step NOUN njb-56 48 34     SPACE njb-56 48 35 were be AUX njb-56 48 36     SPACE njb-56 48 37 same same ADJ njb-56 48 38     SPACE njb-56 48 39 as as SCONJ njb-56 48 40     SPACE njb-56 48 41 described describe VERB njb-56 48 42     SPACE njb-56 48 43 above above ADP njb-56 48 44 . . PUNCT njb-56 48 45     SPACE njb-56 48 46 genomic genomic ADJ njb-56 48 47     SPACE njb-56 48 48 dna dna PROPN njb-56 48 49     SPACE njb-56 48 50 visualization visualization NOUN njb-56 48 51 : : PUNCT njb-56 48 52     SPACE njb-56 48 53 the the DET njb-56 48 54     SPACE njb-56 48 55 extracted extract VERB njb-56 48 56     SPACE njb-56 48 57 dna dna PROPN njb-56 48 58     SPACE njb-56 48 59 was be AUX njb-56 48 60     SPACE njb-56 48 61 visualized visualize VERB njb-56 48 62     SPACE njb-56 48 63 in in ADP njb-56 48 64     SPACE njb-56 48 65 a a DET njb-56 48 66     SPACE njb-56 48 67 0.8 0.8 NUM njb-56 48 68 % % NOUN njb-56 48 69     SPACE njb-56 48 70 agarose agarose NOUN njb-56 48 71     SPACE njb-56 48 72 ( ( PUNCT njb-56 48 73 amresco amresco PROPN njb-56 48 74 ® ® NOUN njb-56 48 75 ) ) PUNCT njb-56 48 76     SPACE njb-56 48 77 gel gel NOUN njb-56 48 78 . . PUNCT njb-56 48 79     SPACE njb-56 49 1 pcr‐rflp pcr‐rflp PROPN njb-56 49 2     SPACE njb-56 49 3 analysis analysis NOUN njb-56 49 4 : : PUNCT njb-56 49 5     SPACE njb-56 49 6 amplification amplification NOUN njb-56 49 7     SPACE njb-56 49 8 of of ADP njb-56 49 9     SPACE njb-56 49 10 the the DET njb-56 49 11     SPACE njb-56 49 12 200 200 NUM njb-56 49 13     SPACE njb-56 49 14 bp bp PROPN njb-56 49 15     SPACE njb-56 49 16 fragment fragment NOUN njb-56 49 17     SPACE njb-56 49 18 with with ADP njb-56 49 19     SPACE njb-56 49 20 katg katg PROPN njb-56 49 21     SPACE njb-56 49 22 codon codon PROPN njb-56 49 23     SPACE njb-56 49 24 315 315 NUM njb-56 49 25     SPACE njb-56 49 26 ( ( PUNCT njb-56 49 27 the the DET njb-56 49 28     SPACE njb-56 49 29 fragment fragment NOUN njb-56 49 30     SPACE njb-56 49 31 in in ADP njb-56 49 32     SPACE njb-56 49 33 katg katg PROPN njb-56 49 34     SPACE njb-56 49 35 from from ADP njb-56 49 36     SPACE njb-56 49 37 nucleotide nucleotide NOUN njb-56 49 38     SPACE njb-56 49 39 positions position NOUN njb-56 49 40     SPACE njb-56 49 41 904 904 NUM njb-56 49 42     SPACE njb-56 49 43 to to ADP njb-56 49 44     SPACE njb-56 49 45 1103 1103 NUM njb-56 49 46 ; ; PUNCT njb-56 49 47     SPACE njb-56 49 48 http:// http:// PROPN njb-56 49 49 genolist.pasteur.fr/tuberculist genolist.pasteur.fr/tuberculist NOUN njb-56 49 50 ) ) PUNCT njb-56 49 51     SPACE njb-56 49 52 was be AUX njb-56 49 53     SPACE njb-56 49 54 performed perform VERB njb-56 49 55     SPACE njb-56 49 56 in in ADP njb-56 49 57     SPACE njb-56 49 58 tpersonal tpersonal ADJ njb-56 49 59     SPACE njb-56 49 60 thermocycler thermocycler NOUN njb-56 49 61     SPACE njb-56 49 62 ( ( PUNCT njb-56 49 63 biometra biometra PROPN njb-56 49 64 ® ® NOUN njb-56 49 65 ) ) PUNCT njb-56 49 66     SPACE njb-56 49 67 with with ADP njb-56 49 68     SPACE njb-56 49 69 primers primer NOUN njb-56 49 70     SPACE njb-56 49 71 katg1f katg1f NOUN njb-56 49 72     SPACE njb-56 49 73 and and CCONJ njb-56 49 74     SPACE njb-56 49 75 katg4rb katg4rb NOUN njb-56 49 76     SPACE njb-56 49 77 ( ( PUNCT njb-56 49 78 mokrousov mokrousov PROPN njb-56 49 79     SPACE njb-56 49 80 et et PROPN njb-56 49 81     SPACE njb-56 49 82 al al PROPN njb-56 49 83 . . PROPN njb-56 49 84 , , PUNCT njb-56 49 85     SPACE njb-56 49 86 2002 2002 NUM njb-56 49 87 ) ) PUNCT njb-56 49 88     SPACE njb-56 49 89 ( ( PUNCT njb-56 49 90 table table NOUN njb-56 49 91     SPACE njb-56 49 92 1 1 NUM njb-56 49 93 ) ) PUNCT njb-56 49 94     SPACE njb-56 49 95 in in ADP njb-56 49 96     SPACE njb-56 49 97 25µl 25µl NOUN njb-56 49 98     SPACE njb-56 49 99 of of ADP njb-56 49 100     SPACE njb-56 49 101 a a DET njb-56 49 102     SPACE njb-56 49 103 pcr pcr NOUN njb-56 49 104     SPACE njb-56 49 105 mixture mixture NOUN njb-56 49 106     SPACE njb-56 49 107 ( ( PUNCT njb-56 49 108 0.4 0.4 NUM njb-56 49 109     SPACE njb-56 49 110 μm μm NOUN njb-56 49 111     SPACE njb-56 49 112 of of ADP njb-56 49 113     SPACE njb-56 49 114 each each DET njb-56 49 115     SPACE njb-56 49 116 primers primer NOUN njb-56 49 117 , , PUNCT njb-56 49 118     SPACE njb-56 49 119 2.5 2.5 NUM njb-56 49 120 mm mm NOUN njb-56 49 121     SPACE njb-56 49 122 of of ADP njb-56 49 123     SPACE njb-56 49 124 dntp dntp ADJ njb-56 49 125     SPACE njb-56 49 126 mix mix NOUN njb-56 49 127 , , PUNCT njb-56 49 128     SPACE njb-56 49 129 1u 1u NOUN njb-56 49 130     SPACE njb-56 49 131 of of ADP njb-56 49 132     SPACE njb-56 49 133 recombinant recombinant ADJ njb-56 49 134     SPACE njb-56 49 135 taq taq PROPN njb-56 49 136     SPACE njb-56 49 137 dna dna PROPN njb-56 49 138     SPACE njb-56 49 139 polymerase polymerase NOUN njb-56 49 140     SPACE njb-56 49 141 ( ( PUNCT njb-56 49 142 fermentas fermenta NOUN njb-56 49 143 ® ® NOUN njb-56 49 144 ) ) PUNCT njb-56 49 145     SPACE njb-56 49 146 and and CCONJ njb-56 49 147     SPACE njb-56 49 148 2.5 2.5 NUM njb-56 49 149     SPACE njb-56 49 150 mm mm NOUN njb-56 49 151     SPACE njb-56 49 152 of of ADP njb-56 49 153     SPACE njb-56 49 154 mgcl2 mgcl2 NOUN njb-56 49 155 ) ) PUNCT njb-56 49 156     SPACE njb-56 49 157 under under ADP njb-56 49 158     SPACE njb-56 49 159 the the DET njb-56 49 160     SPACE njb-56 49 161 following follow VERB njb-56 49 162     SPACE njb-56 49 163 conditions condition NOUN njb-56 49 164 : : PUNCT njb-56 49 165     SPACE njb-56 49 166 initial initial ADJ njb-56 49 167     SPACE njb-56 49 168 denaturation denaturation NOUN njb-56 49 169     SPACE njb-56 49 170 at at ADP njb-56 49 171     SPACE njb-56 49 172 94⁰c 94⁰c NOUN njb-56 49 173     SPACE njb-56 49 174 for for ADP njb-56 49 175     SPACE njb-56 49 176 5 5 NUM njb-56 49 177     SPACE njb-56 49 178 min min NOUN njb-56 49 179 ; ; PUNCT njb-56 49 180     SPACE njb-56 49 181 30 30 NUM njb-56 49 182     SPACE njb-56 49 183 cycles cycle NOUN njb-56 49 184     SPACE njb-56 49 185 of of ADP njb-56 49 186     SPACE njb-56 49 187 94⁰c 94⁰c NOUN njb-56 49 188     SPACE njb-56 49 189 for for ADP njb-56 49 190     SPACE njb-56 49 191 1 1 NUM njb-56 49 192     SPACE njb-56 49 193 min min PROPN njb-56 49 194 , , PUNCT njb-56 49 195     SPACE njb-56 49 196 56⁰c 56⁰c PROPN njb-56 49 197     SPACE njb-56 49 198 for for ADP njb-56 49 199     SPACE njb-56 49 200 45 45 NUM njb-56 49 201     SPACE njb-56 49 202 sec sec PROPN njb-56 49 203     SPACE njb-56 49 204 and and CCONJ njb-56 49 205     SPACE njb-56 49 206 72⁰c 72⁰c NOUN njb-56 49 207     SPACE njb-56 49 208 for for ADP njb-56 49 209     SPACE njb-56 49 210 45 45 NUM njb-56 49 211     SPACE njb-56 49 212 sec sec PROPN njb-56 49 213 ; ; PUNCT njb-56 49 214     SPACE njb-56 49 215 and and CCONJ njb-56 49 216     SPACE njb-56 49 217 a a DET njb-56 49 218     SPACE njb-56 49 219 final final ADJ njb-56 49 220     SPACE njb-56 49 221 elongation elongation NOUN njb-56 49 222     SPACE njb-56 49 223 at at ADP njb-56 49 224     SPACE njb-56 49 225 72⁰c 72⁰c NOUN njb-56 49 226     SPACE njb-56 49 227 for for ADP njb-56 49 228     SPACE njb-56 49 229 5 5 NUM njb-56 49 230     SPACE njb-56 49 231 min min PROPN njb-56 49 232 . . PROPN njb-56 49 233     SPACE njb-56 49 234 the the DET njb-56 49 235     SPACE njb-56 49 236 amplified amplify VERB njb-56 49 237     SPACE njb-56 49 238 fragment fragment NOUN njb-56 49 239     SPACE njb-56 49 240 was be AUX njb-56 49 241     SPACE njb-56 49 242 assessed assess VERB njb-56 49 243     SPACE njb-56 49 244 by by ADP njb-56 49 245     SPACE njb-56 49 246 electrophoresis electrophoresis NOUN njb-56 49 247     SPACE njb-56 49 248 in in ADP njb-56 49 249     SPACE njb-56 49 250 a a DET njb-56 49 251     SPACE njb-56 49 252 2 2 NUM njb-56 49 253 % % NOUN njb-56 49 254     SPACE njb-56 49 255 agarose agarose NOUN njb-56 49 256     SPACE njb-56 49 257 gel gel NOUN njb-56 49 258     SPACE njb-56 49 259 and and CCONJ njb-56 49 260     SPACE njb-56 49 261 cleaved cleave VERB njb-56 49 262     SPACE njb-56 49 263 with with ADP njb-56 49 264     SPACE njb-56 49 265 restriction restriction NOUN njb-56 49 266     SPACE njb-56 49 267 enzyme enzyme NOUN njb-56 49 268     SPACE njb-56 49 269 mspi mspi NOUN njb-56 49 270     SPACE njb-56 49 271 ( ( PUNCT njb-56 49 272 hpaii hpaii PROPN njb-56 49 273 ) ) PUNCT njb-56 49 274     SPACE njb-56 49 275 ( ( PUNCT njb-56 49 276 fermentas fermenta NOUN njb-56 49 277 ® ® NOUN njb-56 49 278 ) ) PUNCT njb-56 49 279     SPACE njb-56 49 280 as as ADV njb-56 49 281     SPACE njb-56 49 282 per per ADP njb-56 49 283     SPACE njb-56 49 284 the the DET njb-56 49 285     SPACE njb-56 49 286 instructions instruction NOUN njb-56 49 287     SPACE njb-56 49 288 of of ADP njb-56 49 289     SPACE njb-56 49 290 the the DET njb-56 49 291     SPACE njb-56 49 292 manufacturer manufacturer NOUN njb-56 49 293 . . PUNCT njb-56 49 294     SPACE njb-56 50 1 the the DET njb-56 50 2     SPACE njb-56 50 3 restriction restriction NOUN njb-56 50 4     SPACE njb-56 50 5 fragments fragment NOUN njb-56 50 6     SPACE njb-56 50 7 obtained obtain VERB njb-56 50 8     SPACE njb-56 50 9 were be AUX njb-56 50 10     SPACE njb-56 50 11 electrophoresed electrophorese VERB njb-56 50 12     SPACE njb-56 50 13 in in ADP njb-56 50 14     SPACE njb-56 50 15 a a DET njb-56 50 16     SPACE njb-56 50 17 2 2 NUM njb-56 50 18 % % NOUN njb-56 50 19     SPACE njb-56 50 20 agarose agarose NOUN njb-56 50 21     SPACE njb-56 50 22 gel gel NOUN njb-56 50 23     SPACE njb-56 50 24 and and CCONJ njb-56 50 25     SPACE njb-56 50 26 were be AUX njb-56 50 27     SPACE njb-56 50 28 visualized visualize VERB njb-56 50 29     SPACE njb-56 50 30 under under ADP njb-56 50 31     SPACE njb-56 50 32 ultra‐violet ultra‐violet NOUN njb-56 50 33     SPACE njb-56 50 34 ( ( PUNCT njb-56 50 35 uv uv NOUN njb-56 50 36 ) ) PUNCT njb-56 50 37     SPACE njb-56 50 38 light light NOUN njb-56 50 39     SPACE njb-56 50 40 on on ADP njb-56 50 41     SPACE njb-56 50 42 a a DET njb-56 50 43     SPACE njb-56 50 44 transilluminator transilluminator NOUN njb-56 50 45     SPACE njb-56 50 46 ( ( PUNCT njb-56 50 47 biometra biometra PROPN njb-56 50 48 ® ® NOUN njb-56 50 49 ) ) PUNCT njb-56 50 50 . . PUNCT njb-56 50 51     SPACE njb-56 50 52 m. m. NOUN njb-56 50 53     SPACE njb-56 50 54 tuberculosis tuberculosis NOUN njb-56 50 55     SPACE njb-56 50 56 h37rv h37rv PROPN njb-56 50 57     SPACE njb-56 50 58 was be AUX njb-56 50 59     SPACE njb-56 50 60 taken take VERB njb-56 50 61     SPACE njb-56 50 62 as as ADP njb-56 50 63     SPACE njb-56 50 64 the the DET njb-56 50 65     SPACE njb-56 50 66 reference reference NOUN njb-56 50 67     SPACE njb-56 50 68 strain strain NOUN njb-56 50 69     SPACE njb-56 50 70 for for ADP njb-56 50 71     SPACE njb-56 50 72 this this DET njb-56 50 73     SPACE njb-56 50 74 study study NOUN njb-56 50 75 . . PUNCT njb-56 50 76     SPACE njb-56 51 1 pcr‐rflp pcr‐rflp PROPN njb-56 51 2     SPACE njb-56 51 3 assay assay PROPN njb-56 51 4     SPACE njb-56 51 5 was be AUX njb-56 51 6     SPACE njb-56 51 7 designed design VERB njb-56 51 8     SPACE njb-56 51 9 to to PART njb-56 51 10     SPACE njb-56 51 11 detect detect VERB njb-56 51 12     SPACE njb-56 51 13 the the DET njb-56 51 14     SPACE njb-56 51 15 katg katg PROPN njb-56 51 16     SPACE njb-56 51 17 codon codon PROPN njb-56 51 18     SPACE njb-56 51 19 mutation mutation NOUN njb-56 51 20     SPACE njb-56 51 21 agc(ser agc(ser NOUN njb-56 51 22 ) ) PUNCT njb-56 51 23     SPACE njb-56 51 24 à à PUNCT njb-56 51 25     SPACE njb-56 51 26 acc(thr acc(thr NOUN njb-56 51 27 ) ) PUNCT njb-56 51 28 , , PUNCT njb-56 51 29     SPACE njb-56 51 30 which which PRON njb-56 51 31     SPACE njb-56 51 32 leads lead VERB njb-56 51 33     SPACE njb-56 51 34 to to ADP njb-56 51 35     SPACE njb-56 51 36 the the DET njb-56 51 37     SPACE njb-56 51 38 inh inh ADJ njb-56 51 39     SPACE njb-56 51 40 resistant resistant ADJ njb-56 51 41     SPACE njb-56 51 42 phenotype phenotype NOUN njb-56 51 43 . . PUNCT njb-56 51 44     SPACE njb-56 52 1 this this DET njb-56 52 2     SPACE njb-56 52 3 mutation mutation NOUN njb-56 52 4     SPACE njb-56 52 5 creates create VERB njb-56 52 6     SPACE njb-56 52 7 an an DET njb-56 52 8     SPACE njb-56 52 9 additional additional ADJ njb-56 52 10     SPACE njb-56 52 11 mspi mspi ADJ njb-56 52 12     SPACE njb-56 52 13 site site NOUN njb-56 52 14     SPACE njb-56 52 15 ( ( PUNCT njb-56 52 16 ccgg ccgg NOUN njb-56 52 17 ) ) PUNCT njb-56 52 18     SPACE njb-56 52 19 and and CCONJ njb-56 52 20     SPACE njb-56 52 21 thus thus ADV njb-56 52 22     SPACE njb-56 52 23 can can AUX njb-56 52 24     SPACE njb-56 52 25 be be AUX njb-56 52 26     SPACE njb-56 52 27 detected detect VERB njb-56 52 28     SPACE njb-56 52 29 by by ADP njb-56 52 30     SPACE njb-56 52 31 use use NOUN njb-56 52 32     SPACE njb-56 52 33 of of ADP njb-56 52 34     SPACE njb-56 52 35 this this DET njb-56 52 36     SPACE njb-56 52 37 restriction restriction NOUN njb-56 52 38     SPACE njb-56 52 39 endonuclease endonuclease NOUN njb-56 52 40 . . PUNCT njb-56 52 41     SPACE njb-56 53 1 as as ADP njb-56 53 2     SPACE njb-56 53 3 a a DET njb-56 53 4     SPACE njb-56 53 5 result result NOUN njb-56 53 6 , , PUNCT njb-56 53 7     SPACE njb-56 53 8 the the DET njb-56 53 9     SPACE njb-56 53 10 longest long ADJ njb-56 53 11     SPACE njb-56 53 12 fragment fragment ADJ njb-56 53 13     SPACE njb-56 53 14 size size NOUN njb-56 53 15     SPACE njb-56 53 16 in in ADP njb-56 53 17     SPACE njb-56 53 18 the the DET njb-56 53 19     SPACE njb-56 53 20 wild wild ADJ njb-56 53 21     SPACE njb-56 53 22 type type NOUN njb-56 53 23     SPACE njb-56 53 24 katg katg PROPN njb-56 53 25     SPACE njb-56 53 26 product product NOUN njb-56 53 27     SPACE njb-56 53 28 would would AUX njb-56 53 29     SPACE njb-56 53 30 be be AUX njb-56 53 31     SPACE njb-56 53 32 153 153 NUM njb-56 53 33     SPACE njb-56 53 34 bp bp PROPN njb-56 53 35     SPACE njb-56 53 36 and and CCONJ njb-56 53 37     SPACE njb-56 53 38 in in ADP njb-56 53 39     SPACE njb-56 53 40 ser315thr ser315thr PROPN njb-56 53 41     SPACE njb-56 53 42 katg katg PROPN njb-56 53 43     SPACE njb-56 53 44 mutant mutant NOUN njb-56 53 45     SPACE njb-56 53 46 the the DET njb-56 53 47     SPACE njb-56 53 48 longest long ADJ njb-56 53 49     SPACE njb-56 53 50 fragment fragment NOUN njb-56 53 51     SPACE njb-56 53 52 would would AUX njb-56 53 53     SPACE njb-56 53 54 be be AUX njb-56 53 55     SPACE njb-56 53 56 132 132 NUM njb-56 53 57     SPACE njb-56 53 58 bp bp PROPN njb-56 53 59     SPACE njb-56 53 60 which which PRON njb-56 53 61     SPACE njb-56 53 62 could could AUX njb-56 53 63     SPACE njb-56 53 64 be be AUX njb-56 53 65     SPACE njb-56 53 66 easily easily ADV njb-56 53 67     SPACE njb-56 53 68 resolved resolve VERB njb-56 53 69     SPACE njb-56 53 70 in in ADP njb-56 53 71     SPACE njb-56 53 72 a a DET njb-56 53 73     SPACE njb-56 53 74 2 2 NUM njb-56 53 75 % % NOUN njb-56 53 76     SPACE njb-56 53 77 agarose agarose NOUN njb-56 53 78     SPACE njb-56 53 79 gel gel NOUN njb-56 53 80     SPACE njb-56 53 81 while while SCONJ njb-56 53 82     SPACE njb-56 53 83 the the DET njb-56 53 84     SPACE njb-56 53 85 shorter short ADJ njb-56 53 86     SPACE njb-56 53 87 bands band NOUN njb-56 53 88     SPACE njb-56 53 89 ( ( PUNCT njb-56 53 90 21 21 NUM njb-56 53 91     SPACE njb-56 53 92 bp bp PROPN njb-56 53 93     SPACE njb-56 53 94 ‐ ‐ AUX njb-56 53 95     SPACE njb-56 53 96 8 8 NUM njb-56 53 97     SPACE njb-56 53 98 bp bp PROPN njb-56 53 99 ) ) PUNCT njb-56 53 100     SPACE njb-56 53 101 can can AUX njb-56 53 102 not not PART njb-56 53 103     SPACE njb-56 53 104 be be AUX njb-56 53 105     SPACE njb-56 53 106 resolved resolve VERB njb-56 53 107     SPACE njb-56 53 108 in in ADP njb-56 53 109     SPACE njb-56 53 110 the the DET njb-56 53 111     SPACE njb-56 53 112 gel gel NOUN njb-56 53 113     SPACE njb-56 53 114 ( ( PUNCT njb-56 53 115 figure figure NOUN njb-56 53 116     SPACE njb-56 53 117 2 2 NUM njb-56 53 118 ) ) PUNCT njb-56 53 119 . . PUNCT njb-56 53 120       SPACE njb-56 54 1 similarly similarly ADV njb-56 54 2 , , PUNCT njb-56 54 3     SPACE njb-56 54 4 514 514 NUM njb-56 54 5     SPACE njb-56 54 6 bp bp PROPN njb-56 54 7     SPACE njb-56 54 8 of of ADP njb-56 54 9     SPACE njb-56 54 10 int4 int4 PROPN njb-56 54 11     SPACE njb-56 54 12 region region NOUN njb-56 54 13     SPACE njb-56 54 14 of of ADP njb-56 54 15     SPACE njb-56 54 16 slc11a1 slc11a1 NOUN njb-56 54 17     SPACE njb-56 54 18 gene gene NOUN njb-56 54 19     SPACE njb-56 54 20 was be AUX njb-56 54 21     SPACE njb-56 54 22 amplified amplify VERB njb-56 54 23     SPACE njb-56 54 24 using use VERB njb-56 54 25     SPACE njb-56 54 26 primers primer NOUN njb-56 54 27     SPACE njb-56 54 28 int4f int4f NOUN njb-56 54 29     SPACE njb-56 54 30 and and CCONJ njb-56 54 31     SPACE njb-56 54 32 int4r int4r NOUN njb-56 54 33     SPACE njb-56 54 34 ( ( PUNCT njb-56 54 35 taype taype NOUN njb-56 54 36     SPACE njb-56 54 37 et et NOUN njb-56 54 38     SPACE njb-56 54 39 al al PROPN njb-56 54 40 . . PROPN njb-56 54 41 , , PUNCT njb-56 54 42     SPACE njb-56 54 43 2006 2006 NUM njb-56 54 44 ) ) PUNCT njb-56 54 45     SPACE njb-56 54 46 ( ( PUNCT njb-56 54 47 table table NOUN njb-56 54 48     SPACE njb-56 54 49 1 1 NUM njb-56 54 50 ) ) PUNCT njb-56 54 51 . . PUNCT njb-56 54 52         SPACE njb-56 55 1 a a DET njb-56 55 2     SPACE njb-56 55 3 25µl 25µl NOUN njb-56 55 4     SPACE njb-56 55 5 of of ADP njb-56 55 6     SPACE njb-56 55 7 a a DET njb-56 55 8     SPACE njb-56 55 9 pcr pcr NOUN njb-56 55 10     SPACE njb-56 55 11 mixture mixture NOUN njb-56 55 12     SPACE njb-56 55 13 ( ( PUNCT njb-56 55 14 0.4 0.4 NUM njb-56 55 15     SPACE njb-56 55 16 μm μm NOUN njb-56 55 17     SPACE njb-56 55 18 of of ADP njb-56 55 19     SPACE njb-56 55 20 each each DET njb-56 55 21     SPACE njb-56 55 22 primers primer NOUN njb-56 55 23 , , PUNCT njb-56 55 24     SPACE njb-56 55 25 2.5 2.5 NUM njb-56 55 26 mm mm NOUN njb-56 55 27     SPACE njb-56 55 28 of of ADP njb-56 55 29     SPACE njb-56 55 30 dntp dntp ADJ njb-56 55 31     SPACE njb-56 55 32 mix mix NOUN njb-56 55 33 , , PUNCT njb-56 55 34     SPACE njb-56 55 35 1u 1u NOUN njb-56 55 36     SPACE njb-56 55 37 of of ADP njb-56 55 38     SPACE njb-56 55 39 recombinant recombinant ADJ njb-56 55 40     SPACE njb-56 55 41 taq taq PROPN njb-56 55 42     SPACE njb-56 55 43 dna dna PROPN njb-56 55 44     SPACE njb-56 55 45 polymerase polymerase NOUN njb-56 55 46     SPACE njb-56 55 47 and and CCONJ njb-56 55 48     SPACE njb-56 55 49 2.5 2.5 NUM njb-56 55 50     SPACE njb-56 55 51 mm mm NOUN njb-56 55 52     SPACE njb-56 55 53 of of ADP njb-56 55 54     SPACE njb-56 55 55 mgcl2 mgcl2 PROPN njb-56 55 56 ) ) PUNCT njb-56 55 57     SPACE njb-56 55 58 was be AUX njb-56 55 59     SPACE njb-56 55 60 prepared prepare VERB njb-56 55 61     SPACE njb-56 55 62 and and CCONJ njb-56 55 63     SPACE njb-56 55 64 the the DET njb-56 55 65     SPACE njb-56 55 66 reaction reaction NOUN njb-56 55 67     SPACE njb-56 55 68 was be AUX njb-56 55 69     SPACE njb-56 55 70 carried carry VERB njb-56 55 71     SPACE njb-56 55 72 out out ADP njb-56 55 73     SPACE njb-56 55 74 under under ADP njb-56 55 75     SPACE njb-56 55 76 the the DET njb-56 55 77     SPACE njb-56 55 78 following follow VERB njb-56 55 79     SPACE njb-56 55 80 condition condition NOUN njb-56 55 81 : : PUNCT njb-56 55 82     SPACE njb-56 55 83 initial initial ADJ njb-56 55 84     SPACE njb-56 55 85 denaturation denaturation NOUN njb-56 55 86     SPACE njb-56 55 87 at at ADP njb-56 55 88     SPACE njb-56 55 89 95⁰c 95⁰c PROPN njb-56 55 90     SPACE njb-56 55 91 for for ADP njb-56 55 92     SPACE njb-56 55 93 5 5 NUM njb-56 55 94     SPACE njb-56 55 95 min min NOUN njb-56 55 96 ; ; PUNCT njb-56 55 97     SPACE njb-56 55 98 30 30 NUM njb-56 55 99     SPACE njb-56 55 100 cycles cycle NOUN njb-56 55 101     SPACE njb-56 55 102 of of ADP njb-56 55 103     SPACE njb-56 55 104 94⁰c 94⁰c NOUN njb-56 55 105     SPACE njb-56 55 106 for for ADP njb-56 55 107     SPACE njb-56 55 108 1 1 NUM njb-56 55 109     SPACE njb-56 55 110 min min PROPN njb-56 55 111 , , PUNCT njb-56 55 112     SPACE njb-56 55 113 61 61 NUM njb-56 55 114 ° ° NOUN njb-56 55 115 c c NOUN njb-56 55 116     SPACE njb-56 55 117 for for ADP njb-56 55 118     SPACE njb-56 55 119 1 1 NUM njb-56 55 120     SPACE njb-56 55 121 min min NOUN njb-56 55 122     SPACE njb-56 55 123 and and CCONJ njb-56 55 124     SPACE njb-56 55 125 72⁰c 72⁰c NOUN njb-56 55 126     SPACE njb-56 55 127 for for ADP njb-56 55 128     SPACE njb-56 55 129 1 1 NUM njb-56 55 130     SPACE njb-56 55 131 min min NOUN njb-56 55 132 ; ; PUNCT njb-56 55 133     SPACE njb-56 55 134 and and CCONJ njb-56 55 135     SPACE njb-56 55 136 a a DET njb-56 55 137     SPACE njb-56 55 138 final final ADJ njb-56 55 139     SPACE njb-56 55 140 elongation elongation NOUN njb-56 55 141     SPACE njb-56 55 142 at at ADP njb-56 55 143     SPACE njb-56 55 144 72⁰c 72⁰c NOUN njb-56 55 145     SPACE njb-56 55 146 for for ADP njb-56 55 147     SPACE njb-56 55 148 4 4 NUM njb-56 55 149     SPACE njb-56 55 150 min min PROPN njb-56 55 151 . . PROPN njb-56 55 152     SPACE njb-56 56 1 the the DET njb-56 56 2     SPACE njb-56 56 3 amplified amplify VERB njb-56 56 4     SPACE njb-56 56 5 fragment fragment NOUN njb-56 56 6     SPACE njb-56 56 7 was be AUX njb-56 56 8     SPACE njb-56 56 9 assessed assess VERB njb-56 56 10     SPACE njb-56 56 11 by by ADP njb-56 56 12     SPACE njb-56 56 13 electrophoresis electrophoresis NOUN njb-56 56 14     SPACE njb-56 56 15 in in ADP njb-56 56 16     SPACE njb-56 56 17 a a DET njb-56 56 18     SPACE njb-56 56 19 2 2 NUM njb-56 56 20 % % NOUN njb-56 56 21     SPACE njb-56 56 22 agarose agarose NOUN njb-56 56 23     SPACE njb-56 56 24 gel gel NOUN njb-56 56 25 . . PUNCT njb-56 56 26     SPACE njb-56 56 27 to to PART njb-56 56 28     SPACE njb-56 56 29 analyze analyze VERB njb-56 56 30     SPACE njb-56 56 31 the the DET njb-56 56 32     SPACE njb-56 56 33 g g X njb-56 56 34 / / SYM njb-56 56 35 c c NOUN njb-56 56 36     SPACE njb-56 56 37 polymorphisms polymorphism NOUN njb-56 56 38     SPACE njb-56 56 39 in in ADP njb-56 56 40     SPACE njb-56 56 41 int4 int4 PROPN njb-56 56 42 , , PUNCT njb-56 56 43     SPACE njb-56 56 44 the the DET njb-56 56 45     SPACE njb-56 56 46 amplified amplify VERB njb-56 56 47     SPACE njb-56 56 48 products product NOUN njb-56 56 49     SPACE njb-56 56 50 were be AUX njb-56 56 51     SPACE njb-56 56 52 cleaved cleave VERB njb-56 56 53     SPACE njb-56 56 54 with with ADP njb-56 56 55     SPACE njb-56 56 56 restriction restriction NOUN njb-56 56 57     SPACE njb-56 56 58 enzyme enzyme NOUN njb-56 56 59     SPACE njb-56 56 60 apai apai NOUN njb-56 56 61     SPACE njb-56 56 62 ( ( PUNCT njb-56 56 63 fermentas fermenta NOUN njb-56 56 64 ® ® NOUN njb-56 56 65 ) ) PUNCT njb-56 56 66     SPACE njb-56 56 67 as as ADV njb-56 56 68     SPACE njb-56 56 69 per per ADP njb-56 56 70     SPACE njb-56 56 71 the the DET njb-56 56 72     SPACE njb-56 56 73 instructions instruction NOUN njb-56 56 74     SPACE njb-56 56 75 of of ADP njb-56 56 76     SPACE njb-56 56 77 the the DET njb-56 56 78     SPACE njb-56 56 79 manufacturer manufacturer NOUN njb-56 56 80 . . PUNCT njb-56 56 81     SPACE njb-56 57 1 the the DET njb-56 57 2     SPACE njb-56 57 3 restriction restriction NOUN njb-56 57 4     SPACE njb-56 57 5 fragments fragment NOUN njb-56 57 6     SPACE njb-56 57 7 obtained obtain VERB njb-56 57 8     SPACE njb-56 57 9 were be AUX njb-56 57 10     SPACE njb-56 57 11 electrophoresed electrophorese VERB njb-56 57 12     SPACE njb-56 57 13 in in ADP njb-56 57 14     SPACE njb-56 57 15 a a DET njb-56 57 16     SPACE njb-56 57 17 2 2 NUM njb-56 57 18 % % NOUN njb-56 57 19     SPACE njb-56 57 20 agarose agarose NOUN njb-56 57 21     SPACE njb-56 57 22 gel gel NOUN njb-56 57 23     SPACE njb-56 57 24 and and CCONJ njb-56 57 25     SPACE njb-56 57 26 were be AUX njb-56 57 27     SPACE njb-56 57 28 visualized visualize VERB njb-56 57 29     SPACE njb-56 57 30 under under ADP njb-56 57 31     SPACE njb-56 57 32 uv uv NOUN njb-56 57 33     SPACE njb-56 57 34 light light NOUN njb-56 57 35     SPACE njb-56 57 36 on on ADP njb-56 57 37     SPACE njb-56 57 38 a a DET njb-56 57 39     SPACE njb-56 57 40 transilluminator transilluminator NOUN njb-56 57 41 . . PUNCT njb-56 57 42       SPACE njb-56 58 1 results result NOUN njb-56 58 2 : : PUNCT njb-56 58 3     SPACE njb-56 58 4 genomic genomic ADJ njb-56 58 5     SPACE njb-56 58 6 dna dna PROPN njb-56 58 7     SPACE njb-56 58 8 visualization visualization NOUN njb-56 58 9 : : PUNCT njb-56 58 10     SPACE njb-56 58 11 all all DET njb-56 58 12     SPACE njb-56 58 13 the the DET njb-56 58 14     SPACE njb-56 58 15 extracted extract VERB njb-56 58 16     SPACE njb-56 58 17 dna dna NOUN njb-56 58 18     SPACE njb-56 58 19 samples sample NOUN njb-56 58 20     SPACE njb-56 58 21 displayed display VERB njb-56 58 22     SPACE njb-56 58 23 a a DET njb-56 58 24     SPACE njb-56 58 25 positive positive ADJ njb-56 58 26     SPACE njb-56 58 27 band band NOUN njb-56 58 28     SPACE njb-56 58 29 when when SCONJ njb-56 58 30     SPACE njb-56 58 31 they they PRON njb-56 58 32     SPACE njb-56 58 33 were be AUX njb-56 58 34     SPACE njb-56 58 35 electrophoresed electrophorese VERB njb-56 58 36     SPACE njb-56 58 37 in in ADP njb-56 58 38     SPACE njb-56 58 39 0.8 0.8 NUM njb-56 58 40 % % NOUN njb-56 58 41     SPACE njb-56 58 42 agarose agarose NOUN njb-56 58 43     SPACE njb-56 58 44 gel gel NOUN njb-56 58 45 . . PUNCT njb-56 58 46     SPACE njb-56 59 1 ( ( PUNCT njb-56 59 2 figure figure NOUN njb-56 59 3     SPACE njb-56 59 4 3 3 NUM njb-56 59 5     SPACE njb-56 59 6 and and CCONJ njb-56 59 7     SPACE njb-56 59 8 4 4 NUM njb-56 59 9 ) ) PUNCT njb-56 59 10     SPACE njb-56 59 11 pcr‐rflp pcr‐rflp PROPN njb-56 59 12     SPACE njb-56 59 13 analysis analysis NOUN njb-56 59 14 : : PUNCT njb-56 59 15     SPACE njb-56 59 16 all all DET njb-56 59 17     SPACE njb-56 59 18 the the DET njb-56 59 19     SPACE njb-56 59 20 24 24 NUM njb-56 59 21     SPACE njb-56 59 22 mtb mtb NOUN njb-56 59 23     SPACE njb-56 59 24 dna dna PROPN njb-56 59 25     SPACE njb-56 59 26 samples sample NOUN njb-56 59 27     SPACE njb-56 59 28 were be AUX njb-56 59 29     SPACE njb-56 59 30 observed observe VERB njb-56 59 31     SPACE njb-56 59 32 to to PART njb-56 59 33     SPACE njb-56 59 34 have have VERB njb-56 59 35     SPACE njb-56 59 36 a a DET njb-56 59 37     SPACE njb-56 59 38 positive positive ADJ njb-56 59 39     SPACE njb-56 59 40 amplification amplification NOUN njb-56 59 41     SPACE njb-56 59 42 for for ADP njb-56 59 43     SPACE njb-56 59 44 katg katg PROPN njb-56 59 45     SPACE njb-56 59 46 gene gene NOUN njb-56 59 47     SPACE njb-56 59 48 fragment fragment NOUN njb-56 59 49 . . PUNCT njb-56 59 50     SPACE njb-56 60 1 an an DET njb-56 60 2     SPACE njb-56 60 3 amplicon amplicon NOUN njb-56 60 4     SPACE njb-56 60 5 of of ADP njb-56 60 6     SPACE njb-56 60 7 200 200 NUM njb-56 60 8     SPACE njb-56 60 9 bp bp PROPN njb-56 60 10     SPACE njb-56 60 11 size size NOUN njb-56 60 12     SPACE njb-56 60 13 were be AUX njb-56 60 14     SPACE njb-56 60 15 observed observe VERB njb-56 60 16     SPACE njb-56 60 17 in in ADP njb-56 60 18     SPACE njb-56 60 19 a a DET njb-56 60 20     SPACE njb-56 60 21 2 2 NUM njb-56 60 22 % % NOUN njb-56 60 23     SPACE njb-56 60 24 agarose agarose NOUN njb-56 60 25     SPACE njb-56 60 26 gel gel NOUN njb-56 60 27     SPACE njb-56 60 28 ( ( PUNCT njb-56 60 29 figure figure NOUN njb-56 60 30     SPACE njb-56 60 31 5 5 NUM njb-56 60 32 ) ) PUNCT njb-56 60 33 . . PUNCT njb-56 60 34       SPACE njb-56 61 1 in in ADP njb-56 61 2     SPACE njb-56 61 3 the the DET njb-56 61 4     SPACE njb-56 61 5 electrophoresis electrophoresis NOUN njb-56 61 6     SPACE njb-56 61 7 of of ADP njb-56 61 8     SPACE njb-56 61 9 the the DET njb-56 61 10     SPACE njb-56 61 11 katg katg PROPN njb-56 61 12     SPACE njb-56 61 13 amplified amplify VERB njb-56 61 14     SPACE njb-56 61 15 product product NOUN njb-56 61 16     SPACE njb-56 61 17 digested digest VERB njb-56 61 18     SPACE njb-56 61 19 with with ADP njb-56 61 20     SPACE njb-56 61 21 mspi mspi NOUN njb-56 61 22 , , PUNCT njb-56 61 23     SPACE njb-56 61 24 4 4 NUM njb-56 61 25     SPACE njb-56 61 26 ( ( PUNCT njb-56 61 27 samples sample NOUN njb-56 61 28     SPACE njb-56 61 29 015 015 NUM njb-56 61 30 , , PUNCT njb-56 61 31     SPACE njb-56 61 32 016 016 NUM njb-56 61 33 , , PUNCT njb-56 61 34     SPACE njb-56 61 35 020 020 NUM njb-56 61 36     SPACE njb-56 61 37 and and CCONJ njb-56 61 38     SPACE njb-56 61 39 024 024 NUM njb-56 61 40 ) ) PUNCT njb-56 61 41     SPACE njb-56 61 42 out out ADV njb-56 61 43     SPACE njb-56 61 44 of of ADP njb-56 61 45     SPACE njb-56 61 46 24 24 NUM njb-56 61 47     SPACE njb-56 61 48 samples sample NOUN njb-56 61 49     SPACE njb-56 61 50 were be AUX njb-56 61 51     SPACE njb-56 61 52 obtained obtain VERB njb-56 61 53     SPACE njb-56 61 54 at at ADP njb-56 61 55     SPACE njb-56 61 56 132 132 NUM njb-56 61 57     SPACE njb-56 61 58 bp bp PROPN njb-56 61 59     SPACE njb-56 61 60 region region NOUN njb-56 61 61     SPACE njb-56 61 62 indicating indicate VERB njb-56 61 63     SPACE njb-56 61 64 the the DET njb-56 61 65     SPACE njb-56 61 66 occurrence occurrence NOUN njb-56 61 67     SPACE njb-56 61 68 of of ADP njb-56 61 69     SPACE njb-56 61 70 ser315thr ser315thr NOUN njb-56 61 71     SPACE njb-56 61 72 mutation mutation NOUN njb-56 61 73     SPACE njb-56 61 74 whereas whereas SCONJ njb-56 61 75     SPACE njb-56 61 76 rest rest NOUN njb-56 61 77     SPACE njb-56 61 78 of of ADP njb-56 61 79     SPACE njb-56 61 80 the the DET njb-56 61 81     SPACE njb-56 61 82 20 20 NUM njb-56 61 83     SPACE njb-56 61 84 samples sample NOUN njb-56 61 85     SPACE njb-56 61 86 were be AUX njb-56 61 87     SPACE njb-56 61 88 obtained obtain VERB njb-56 61 89     SPACE njb-56 61 90 at at ADP njb-56 61 91     SPACE njb-56 61 92 153 153 NUM njb-56 61 93     SPACE njb-56 61 94 bp bp PROPN njb-56 61 95     SPACE njb-56 61 96 region region NOUN njb-56 61 97     SPACE njb-56 61 98 indication indication NOUN njb-56 61 99     SPACE njb-56 61 100 no no DET njb-56 61 101     SPACE njb-56 61 102 ser315thr ser315thr NOUN njb-56 61 103     SPACE njb-56 61 104 mutation mutation NOUN njb-56 61 105     SPACE njb-56 61 106 ( ( PUNCT njb-56 61 107 figure figure NOUN njb-56 61 108     SPACE njb-56 61 109 6 6 NUM njb-56 61 110 ) ) PUNCT njb-56 61 111 . . PUNCT njb-56 61 112     SPACE njb-56 62 1 gel gel NOUN njb-56 62 2     SPACE njb-56 62 3 picture picture NOUN njb-56 62 4     SPACE njb-56 62 5 of of ADP njb-56 62 6     SPACE njb-56 62 7 samples sample NOUN njb-56 62 8     SPACE njb-56 62 9 015 015 NUM njb-56 62 10     SPACE njb-56 62 11 and and CCONJ njb-56 62 12     SPACE njb-56 62 13 016 016 NUM njb-56 62 14     SPACE njb-56 62 15 are be AUX njb-56 62 16     SPACE njb-56 62 17 not not PART njb-56 62 18     SPACE njb-56 62 19 shown show VERB njb-56 62 20 . . PUNCT njb-56 62 21     SPACE njb-56 62 22 all all DET njb-56 62 23     SPACE njb-56 62 24 the the DET njb-56 62 25     SPACE njb-56 62 26 24 24 NUM njb-56 62 27     SPACE njb-56 62 28 human human ADJ njb-56 62 29     SPACE njb-56 62 30 dna dna PROPN njb-56 62 31     SPACE njb-56 62 32 samples sample NOUN njb-56 62 33     SPACE njb-56 62 34 from from ADP njb-56 62 35     SPACE njb-56 62 36 whole whole ADJ njb-56 62 37     SPACE njb-56 62 38 blood blood NOUN njb-56 62 39     SPACE njb-56 62 40 had have VERB njb-56 62 41     SPACE njb-56 62 42 a a DET njb-56 62 43     SPACE njb-56 62 44 positive positive ADJ njb-56 62 45     SPACE njb-56 62 46 amplification amplification NOUN njb-56 62 47     SPACE njb-56 62 48 at at ADP njb-56 62 49     SPACE njb-56 62 50 514 514 NUM njb-56 62 51     SPACE njb-56 62 52 bp bp PROPN njb-56 62 53     SPACE njb-56 62 54 region region NOUN njb-56 62 55     SPACE njb-56 62 56 for for ADP njb-56 62 57     SPACE njb-56 62 58 int4 int4 PROPN njb-56 62 59     SPACE njb-56 62 60 ( ( PUNCT njb-56 62 61 figure figure NOUN njb-56 62 62     SPACE njb-56 62 63 7 7 NUM njb-56 62 64 ) ) PUNCT njb-56 62 65 . . PUNCT njb-56 62 66     SPACE njb-56 63 1 when when SCONJ njb-56 63 2     SPACE njb-56 63 3 these these DET njb-56 63 4     SPACE njb-56 63 5 amplicons amplicon NOUN njb-56 63 6     SPACE njb-56 63 7 were be AUX njb-56 63 8     SPACE njb-56 63 9 subjected subject VERB njb-56 63 10     SPACE njb-56 63 11 to to ADP njb-56 63 12     SPACE njb-56 63 13 apai apai NOUN njb-56 63 14     SPACE njb-56 63 15 digestion digestion NOUN njb-56 63 16 , , PUNCT njb-56 63 17     SPACE njb-56 63 18 all all PRON njb-56 63 19     SPACE njb-56 63 20 of of ADP njb-56 63 21     SPACE njb-56 63 22 the the DET njb-56 63 23     SPACE njb-56 63 24 24 24 NUM njb-56 63 25     SPACE njb-56 63 26 samples sample NOUN njb-56 63 27     SPACE njb-56 63 28 were be AUX njb-56 63 29     SPACE njb-56 63 30 observed observe VERB njb-56 63 31     SPACE njb-56 63 32 at at ADP njb-56 63 33     SPACE njb-56 63 34 514 514 NUM njb-56 63 35     SPACE njb-56 63 36 bp bp PROPN njb-56 63 37     SPACE njb-56 63 38 region region NOUN njb-56 63 39     SPACE njb-56 63 40 indicating indicate VERB njb-56 63 41     SPACE njb-56 63 42 no no PRON njb-56 63 43     SPACE njb-56 63 44 g g X njb-56 63 45 / / SYM njb-56 63 46 c c NOUN njb-56 63 47     SPACE njb-56 63 48 polymorphisms polymorphism NOUN njb-56 63 49     SPACE njb-56 63 50 in in ADP njb-56 63 51     SPACE njb-56 63 52 int4 int4 PROPN njb-56 63 53     SPACE njb-56 63 54 region region NOUN njb-56 63 55     SPACE njb-56 63 56 of of ADP njb-56 63 57     SPACE njb-56 63 58 slc11a1 slc11a1 NOUN njb-56 63 59     SPACE njb-56 63 60 ( ( PUNCT njb-56 63 61 figure figure NOUN njb-56 63 62     SPACE njb-56 63 63 8) 8) NUM njb-56 63 64 . . PUNCT njb-56 63 65       SPACE njb-56 63 66 discussion discussion NOUN njb-56 63 67     SPACE njb-56 63 68 south south PROPN njb-56 63 69     SPACE njb-56 63 70 asia asia PROPN njb-56 63 71     SPACE njb-56 63 72 holds hold VERB njb-56 63 73     SPACE njb-56 63 74 around around ADP njb-56 63 75     SPACE njb-56 63 76 40 40 NUM njb-56 63 77 % % NOUN njb-56 63 78     SPACE njb-56 63 79 of of ADP njb-56 63 80     SPACE njb-56 63 81 the the DET njb-56 63 82     SPACE njb-56 63 83 global global PROPN njb-56 63 84     SPACE njb-56 63 85 tb tb PROPN njb-56 63 86     SPACE njb-56 63 87 burden burden NOUN njb-56 63 88     SPACE njb-56 63 89 and and CCONJ njb-56 63 90     SPACE njb-56 63 91 nepal nepal ADJ njb-56 63 92     SPACE njb-56 63 93 has have VERB njb-56 63 94     SPACE njb-56 63 95 no no DET njb-56 63 96     SPACE njb-56 63 97 different different ADJ njb-56 63 98     SPACE njb-56 63 99 scenario scenario NOUN njb-56 63 100 . . PUNCT njb-56 63 101     SPACE njb-56 64 1 the the DET njb-56 64 2     SPACE njb-56 64 3 millennium millennium NOUN njb-56 64 4     SPACE njb-56 64 5 development development NOUN njb-56 64 6     SPACE njb-56 64 7 goal goal NOUN njb-56 64 8     SPACE njb-56 64 9 ( ( PUNCT njb-56 64 10 mdg mdg PROPN njb-56 64 11 ) ) PUNCT njb-56 64 12     SPACE njb-56 64 13 aims aim VERB njb-56 64 14     SPACE njb-56 64 15 to to PART njb-56 64 16     SPACE njb-56 64 17 eliminate eliminate VERB njb-56 64 18     SPACE njb-56 64 19 tb tb NOUN njb-56 64 20     SPACE njb-56 64 21 as as ADP njb-56 64 22     SPACE njb-56 64 23 a a DET njb-56 64 24     SPACE njb-56 64 25 public public ADJ njb-56 64 26     SPACE njb-56 64 27 health health NOUN njb-56 64 28     SPACE njb-56 64 29 problem problem NOUN njb-56 64 30     SPACE njb-56 64 31 ( ( PUNCT njb-56 64 32 1 1 NUM njb-56 64 33     SPACE njb-56 64 34 case case NOUN njb-56 64 35     SPACE njb-56 64 36 per per ADP njb-56 64 37     SPACE njb-56 64 38 million million NUM njb-56 64 39     SPACE njb-56 64 40 population population NOUN njb-56 64 41 ) ) PUNCT njb-56 64 42     SPACE njb-56 64 43 by by ADP njb-56 64 44     SPACE njb-56 64 45 2050 2050 NUM njb-56 64 46 . . PUNCT njb-56 64 47     SPACE njb-56 65 1 nepal nepal ADJ njb-56 65 2     SPACE njb-56 65 3 has have AUX njb-56 65 4     SPACE njb-56 65 5 made make VERB njb-56 65 6     SPACE njb-56 65 7 satisfactory satisfactory ADJ njb-56 65 8     SPACE njb-56 65 9 progress progress NOUN njb-56 65 10     SPACE njb-56 65 11 towards towards ADP njb-56 65 12     SPACE njb-56 65 13 mdg mdg PROPN njb-56 65 14 . . PUNCT njb-56 65 15     SPACE njb-56 65 16 however however ADV njb-56 65 17 , , PUNCT njb-56 65 18     SPACE njb-56 65 19 the the DET njb-56 65 20     SPACE njb-56 65 21 challenges challenge NOUN njb-56 65 22     SPACE njb-56 65 23 to to PART njb-56 65 24     SPACE njb-56 65 25 address address VERB njb-56 65 26     SPACE njb-56 65 27 the the DET njb-56 65 28     SPACE njb-56 65 29 growing grow VERB njb-56 65 30     SPACE njb-56 65 31 burden burden NOUN njb-56 65 32     SPACE njb-56 65 33 of of ADP njb-56 65 34     SPACE njb-56 65 35 tb tb PROPN njb-56 65 36     SPACE njb-56 65 37 and and CCONJ njb-56 65 38     SPACE njb-56 65 39 mdr‐tb mdr‐tb ADJ njb-56 65 40     SPACE njb-56 65 41 population population NOUN njb-56 65 42     SPACE njb-56 65 43 are be AUX njb-56 65 44     SPACE njb-56 65 45 yet yet ADV njb-56 65 46     SPACE njb-56 65 47 far far ADV njb-56 65 48     SPACE njb-56 65 49 away away ADV njb-56 65 50 . . PUNCT njb-56 65 51     SPACE njb-56 65 52 nepal nepal ADJ njb-56 65 53     SPACE njb-56 65 54 still still ADV njb-56 65 55     SPACE njb-56 65 56 lacks lack VERB njb-56 65 57     SPACE njb-56 65 58 the the DET njb-56 65 59     SPACE njb-56 65 60 health health NOUN njb-56 65 61     SPACE njb-56 65 62 care care NOUN njb-56 65 63     SPACE njb-56 65 64 facilities facility NOUN njb-56 65 65     SPACE njb-56 65 66 and and CCONJ njb-56 65 67     SPACE njb-56 65 68 access access NOUN njb-56 65 69     SPACE njb-56 65 70 to to ADP njb-56 65 71     SPACE njb-56 65 72 modern modern ADJ njb-56 65 73     SPACE njb-56 65 74 diagnostic diagnostic ADJ njb-56 65 75     SPACE njb-56 65 76 technologies technology NOUN njb-56 65 77     SPACE njb-56 65 78 is be AUX njb-56 65 79     SPACE njb-56 65 80 very very ADV njb-56 65 81     SPACE njb-56 65 82 poor poor ADJ njb-56 65 83     SPACE njb-56 65 84 in in ADP njb-56 65 85     SPACE njb-56 65 86 the the DET njb-56 65 87     SPACE njb-56 65 88 area area NOUN njb-56 65 89     SPACE njb-56 65 90 ( ( PUNCT njb-56 65 91 basnet basnet PROPN njb-56 65 92     SPACE njb-56 65 93 et et PROPN njb-56 65 94     SPACE njb-56 65 95 al al PROPN njb-56 65 96 . . PROPN njb-56 65 97 , , PUNCT njb-56 65 98     SPACE njb-56 65 99 2009 2009 NUM njb-56 65 100 ) ) PUNCT njb-56 65 101 . . PUNCT njb-56 65 102     SPACE njb-56 66 1 although although SCONJ njb-56 66 2     SPACE njb-56 66 3 directly directly ADV njb-56 66 4     SPACE njb-56 66 5 observed observe VERB njb-56 66 6     SPACE njb-56 66 7 treatment treatment NOUN njb-56 66 8 , , PUNCT njb-56 66 9     SPACE njb-56 66 10 short‐course short‐course NOUN njb-56 66 11     SPACE njb-56 66 12 ( ( PUNCT njb-56 66 13 dots dot NOUN njb-56 66 14 ) ) PUNCT njb-56 66 15     SPACE njb-56 66 16 strategy strategy NOUN njb-56 66 17     SPACE njb-56 66 18 has have AUX njb-56 66 19     SPACE njb-56 66 20 significantly significantly ADV njb-56 66 21     SPACE njb-56 66 22 contributed contribute VERB njb-56 66 23     SPACE njb-56 66 24 towards towards ADP njb-56 66 25     SPACE njb-56 66 26 the the DET njb-56 66 27     SPACE njb-56 66 28 treatment treatment NOUN njb-56 66 29     SPACE njb-56 66 30 of of ADP njb-56 66 31     SPACE njb-56 66 32 tb tb PROPN njb-56 66 33 , , PUNCT njb-56 66 34     SPACE njb-56 66 35 a a DET njb-56 66 36     SPACE njb-56 66 37 lack lack NOUN njb-56 66 38     SPACE njb-56 66 39 of of ADP njb-56 66 40     SPACE njb-56 66 41 rapid rapid ADJ njb-56 66 42     SPACE njb-56 66 43 and and CCONJ njb-56 66 44     SPACE njb-56 66 45 sensitive sensitive ADJ njb-56 66 46     SPACE njb-56 66 47 rapid rapid ADJ njb-56 66 48     SPACE njb-56 66 49 and and CCONJ njb-56 66 50     SPACE njb-56 66 51 sensitive sensitive ADJ njb-56 66 52     SPACE njb-56 66 53 methods method NOUN njb-56 66 54     SPACE njb-56 66 55 of of ADP njb-56 66 56     SPACE njb-56 66 57 detection detection NOUN njb-56 66 58     SPACE njb-56 66 59 is be AUX njb-56 66 60     SPACE njb-56 66 61 a a DET njb-56 66 62     SPACE njb-56 66 63 major major ADJ njb-56 66 64     SPACE njb-56 66 65 hindrance hindrance NOUN njb-56 66 66     SPACE njb-56 66 67 to to ADP njb-56 66 68     SPACE njb-56 66 69 the the DET njb-56 66 70     SPACE njb-56 66 71 ongoing ongoing ADJ njb-56 66 72     SPACE njb-56 66 73 battle battle NOUN njb-56 66 74     SPACE njb-56 66 75 against against ADP njb-56 66 76     SPACE njb-56 66 77 the the DET njb-56 66 78     SPACE njb-56 66 79 disease disease NOUN njb-56 66 80 . . PUNCT njb-56 66 81     SPACE njb-56 67 1 afb afb PROPN njb-56 67 2     SPACE njb-56 67 3 microscopy microscopy NOUN njb-56 67 4     SPACE njb-56 67 5 is be AUX njb-56 67 6     SPACE njb-56 67 7 the the DET njb-56 67 8     SPACE njb-56 67 9 primary primary ADJ njb-56 67 10     SPACE njb-56 67 11 screening screening NOUN njb-56 67 12     SPACE njb-56 67 13 tool tool NOUN njb-56 67 14     SPACE njb-56 67 15 for for ADP njb-56 67 16     SPACE njb-56 67 17 tb tb PROPN njb-56 67 18     SPACE njb-56 67 19 and and CCONJ njb-56 67 20     SPACE njb-56 67 21 culture culture NOUN njb-56 67 22     SPACE njb-56 67 23 of of ADP njb-56 67 24     SPACE njb-56 67 25 mycobacteria mycobacterium NOUN njb-56 67 26     SPACE njb-56 67 27 is be AUX njb-56 67 28     SPACE njb-56 67 29 still still ADV njb-56 67 30     SPACE njb-56 67 31 regarded regard VERB njb-56 67 32     SPACE njb-56 67 33 as as ADP njb-56 67 34     SPACE njb-56 67 35 the the DET njb-56 67 36     SPACE njb-56 67 37 “ " PUNCT njb-56 67 38 gold gold ADJ njb-56 67 39     SPACE njb-56 67 40 standard standard NOUN njb-56 67 41 ” " PUNCT njb-56 67 42     SPACE njb-56 67 43 in in ADP njb-56 67 44     SPACE njb-56 67 45 tb tb NOUN njb-56 67 46     SPACE njb-56 67 47 diagnosis diagnosis NOUN njb-56 67 48 . . PUNCT njb-56 67 49     SPACE njb-56 68 1 but but CCONJ njb-56 68 2     SPACE njb-56 68 3 these these DET njb-56 68 4     SPACE njb-56 68 5 days day NOUN njb-56 68 6     SPACE njb-56 68 7 new new ADJ njb-56 68 8     SPACE njb-56 68 9 nepal nepal ADJ njb-56 68 10     SPACE njb-56 68 11 journal journal NOUN njb-56 68 12     SPACE njb-56 68 13 of of ADP njb-56 68 14     SPACE njb-56 68 15 biotechnology biotechnology NOUN njb-56 68 16 . . PUNCT njb-56 68 17     SPACE njb-56 69 1 jan jan PROPN njb-56 69 2 . . PROPN njb-56 69 3     SPACE njb-56 69 4 2011 2011 NUM njb-56 69 5 , , PUNCT njb-56 69 6     SPACE njb-56 69 7 vol vol NOUN njb-56 69 8 . . PUNCT njb-56 69 9     SPACE njb-56 69 10 1 1 NUM njb-56 69 11 , , PUNCT njb-56 69 12     SPACE njb-56 69 13 no no INTJ njb-56 69 14 . . PUNCT njb-56 69 15     SPACE njb-56 70 1 1 1 X njb-56 70 2     SPACE njb-56 70 3 : : PUNCT njb-56 70 4     SPACE njb-56 70 5 14‐21 14‐21 NUM njb-56 70 6     SPACE njb-56 70 7 17 17 NUM njb-56 70 8       SPACE njb-56 70 9 biotechnology biotechnology NOUN njb-56 70 10     SPACE njb-56 70 11 society society NOUN njb-56 70 12     SPACE njb-56 70 13 of of ADP njb-56 70 14     SPACE njb-56 70 15 nepal nepal NOUN njb-56 70 16     SPACE njb-56 70 17 ( ( PUNCT njb-56 70 18 bsn bsn PROPN njb-56 70 19 ) ) PUNCT njb-56 70 20 , , PUNCT njb-56 70 21     SPACE njb-56 70 22 all all DET njb-56 70 23     SPACE njb-56 70 24 rights right NOUN njb-56 70 25     SPACE njb-56 70 26 reserved reserve VERB njb-56 70 27       SPACE njb-56 70 28 target target NOUN njb-56 70 29     SPACE njb-56 70 30 gene gene NOUN njb-56 70 31     SPACE njb-56 70 32 region region NOUN njb-56 70 33     SPACE njb-56 70 34 primer primer NOUN njb-56 70 35     SPACE njb-56 70 36 sequence sequence NOUN njb-56 70 37     SPACE njb-56 70 38 katg katg PROPN njb-56 70 39     SPACE njb-56 70 40 katg1f katg1f PROPN njb-56 70 41     SPACE njb-56 70 42 5'‐agctcgtatggcaccggaac‐3 5'‐agctcgtatggcaccggaac‐3 NUM njb-56 70 43 ’ ' PUNCT njb-56 70 44     SPACE njb-56 70 45 katg4rb katg4rb NOUN njb-56 70 46     SPACE njb-56 70 47 5'‐aacgggtccgggatggtg‐3 5'‐aacgggtccgggatggtg‐3 PROPN njb-56 70 48 ' ' PUNCT njb-56 70 49     SPACE njb-56 70 50 int4 int4 PROPN njb-56 70 51     SPACE njb-56 70 52 int4f int4f NOUN njb-56 70 53     SPACE njb-56 70 54 5'‐gtctgccatctctactaccctaaggtg‐3 5'‐gtctgccatctctactaccctaaggtg‐3 NUM njb-56 70 55 ’ ' PUNCT njb-56 70 56     SPACE njb-56 70 57 int4r int4r NOUN njb-56 70 58     SPACE njb-56 70 59 5'‐catgtccctctaggtatgtgctatcag‐3 5'‐catgtccctctaggtatgtgctatcag‐3 NUM njb-56 70 60 ' ' PART njb-56 70 61     SPACE njb-56 70 62 table table NOUN njb-56 70 63     SPACE njb-56 70 64 1 1 NUM njb-56 70 65 . . PUNCT njb-56 70 66     SPACE njb-56 70 67 primer primer NOUN njb-56 70 68     SPACE njb-56 70 69 sequence sequence NOUN njb-56 70 70     SPACE njb-56 70 71 for for ADP njb-56 70 72     SPACE njb-56 70 73 katg katg PROPN njb-56 70 74     SPACE njb-56 70 75 and and CCONJ njb-56 70 76     SPACE njb-56 70 77 int4 int4 PROPN njb-56 70 78     SPACE njb-56 70 79 figure figure NOUN njb-56 70 80     SPACE njb-56 70 81 2 2 NUM njb-56 70 82 . . PUNCT njb-56 70 83     SPACE njb-56 70 84 schematic schematic ADJ njb-56 70 85     SPACE njb-56 70 86 illustration illustration NOUN njb-56 70 87     SPACE njb-56 70 88 of of ADP njb-56 70 89     SPACE njb-56 70 90 the the DET njb-56 70 91     SPACE njb-56 70 92 katg katg PROPN njb-56 70 93     SPACE njb-56 70 94 200‐bp 200‐bp NUM njb-56 70 95     SPACE njb-56 70 96 fragment fragment NOUN njb-56 70 97     SPACE njb-56 70 98 amplified amplify VERB njb-56 70 99     SPACE njb-56 70 100 with with ADP njb-56 70 101     SPACE njb-56 70 102 primers primer NOUN njb-56 70 103     SPACE njb-56 70 104 katg1f katg1f NOUN njb-56 70 105     SPACE njb-56 70 106 and and CCONJ njb-56 70 107     SPACE njb-56 70 108 katg4rb katg4rb PROPN njb-56 70 109 . . PUNCT njb-56 70 110     SPACE njb-56 71 1 the the DET njb-56 71 2     SPACE njb-56 71 3 vertical vertical ADJ njb-56 71 4     SPACE njb-56 71 5 line line NOUN njb-56 71 6     SPACE njb-56 71 7 represents represent VERB njb-56 71 8     SPACE njb-56 71 9 the the DET njb-56 71 10     SPACE njb-56 71 11 mspi mspi ADJ njb-56 71 12     SPACE njb-56 71 13 restriction restriction NOUN njb-56 71 14     SPACE njb-56 71 15 site site NOUN njb-56 71 16     SPACE njb-56 71 17 ( ( PUNCT njb-56 71 18 ccgg ccgg NOUN njb-56 71 19 ) ) PUNCT njb-56 71 20 . . PUNCT njb-56 71 21     SPACE njb-56 72 1 in in ADP njb-56 72 2     SPACE njb-56 72 3 the the DET njb-56 72 4     SPACE njb-56 72 5 wild‐type wild‐type CCONJ njb-56 72 6     SPACE njb-56 72 7 katg katg PROPN njb-56 72 8     SPACE njb-56 72 9 pcr pcr PROPN njb-56 72 10     SPACE njb-56 72 11 product product NOUN njb-56 72 12     SPACE njb-56 72 13 there there PRON njb-56 72 14     SPACE njb-56 72 15 is be AUX njb-56 72 16     SPACE njb-56 72 17 no no DET njb-56 72 18     SPACE njb-56 72 19 mspi mspi NOUN njb-56 72 20     SPACE njb-56 72 21 restriction restriction NOUN njb-56 72 22     SPACE njb-56 72 23 site site NOUN njb-56 72 24     SPACE njb-56 72 25 at at ADP njb-56 72 26     SPACE njb-56 72 27 315th 315th ADJ njb-56 72 28     SPACE njb-56 72 29 codon codon NOUN njb-56 72 30     SPACE njb-56 72 31 ( ( PUNCT njb-56 72 32 agc agc PROPN njb-56 72 33 ) ) PUNCT njb-56 72 34     SPACE njb-56 72 35 and and CCONJ njb-56 72 36     SPACE njb-56 72 37 the the DET njb-56 72 38     SPACE njb-56 72 39 longest long ADJ njb-56 72 40     SPACE njb-56 72 41 fragment fragment NOUN njb-56 72 42     SPACE njb-56 72 43 is be AUX njb-56 72 44     SPACE njb-56 72 45 of of ADP njb-56 72 46     SPACE njb-56 72 47 153 153 NUM njb-56 72 48     SPACE njb-56 72 49 bp bp PROPN njb-56 72 50 . . PROPN njb-56 72 51     SPACE njb-56 73 1 but but CCONJ njb-56 73 2     SPACE njb-56 73 3 in in ADP njb-56 73 4     SPACE njb-56 73 5 the the DET njb-56 73 6     SPACE njb-56 73 7 mutant mutant ADJ njb-56 73 8     SPACE njb-56 73 9 katg katg PROPN njb-56 73 10     SPACE njb-56 73 11 pcr pcr PROPN njb-56 73 12     SPACE njb-56 73 13 product product NOUN njb-56 73 14     SPACE njb-56 73 15 there there PRON njb-56 73 16     SPACE njb-56 73 17 is be AUX njb-56 73 18     SPACE njb-56 73 19 an an DET njb-56 73 20     SPACE njb-56 73 21 addition addition NOUN njb-56 73 22     SPACE njb-56 73 23 of of ADP njb-56 73 24     SPACE njb-56 73 25 mspi mspi ADJ njb-56 73 26     SPACE njb-56 73 27 restriction restriction NOUN njb-56 73 28     SPACE njb-56 73 29 site site NOUN njb-56 73 30     SPACE njb-56 73 31 at at ADP njb-56 73 32     SPACE njb-56 73 33 315th 315th ADJ njb-56 73 34     SPACE njb-56 73 35 codon codon NOUN njb-56 73 36     SPACE njb-56 73 37 ( ( PUNCT njb-56 73 38 acc acc PROPN njb-56 73 39 ) ) PUNCT njb-56 73 40     SPACE njb-56 73 41 and and CCONJ njb-56 73 42     SPACE njb-56 73 43 it it PRON njb-56 73 44     SPACE njb-56 73 45 gives give VERB njb-56 73 46     SPACE njb-56 73 47 132 132 NUM njb-56 73 48     SPACE njb-56 73 49 bp bp PROPN njb-56 73 50     SPACE njb-56 73 51 band band NOUN njb-56 73 52     SPACE njb-56 73 53 as as ADP njb-56 73 54     SPACE njb-56 73 55 the the DET njb-56 73 56     SPACE njb-56 73 57 longest long ADJ njb-56 73 58     SPACE njb-56 73 59 fragment fragment ADJ njb-56 73 60 . . PUNCT njb-56 73 61     SPACE njb-56 74 1 figure figure VERB njb-56 74 2     SPACE njb-56 74 3 3 3 NUM njb-56 74 4 . . PUNCT njb-56 74 5     SPACE njb-56 75 1 visualization visualization NOUN njb-56 75 2     SPACE njb-56 75 3 of of ADP njb-56 75 4     SPACE njb-56 75 5 the the DET njb-56 75 6     SPACE njb-56 75 7 extracted extract VERB njb-56 75 8     SPACE njb-56 75 9 mtb mtb NOUN njb-56 75 10     SPACE njb-56 75 11 dna dna PROPN njb-56 75 12     SPACE njb-56 75 13 from from ADP njb-56 75 14     SPACE njb-56 75 15 cultured cultured ADJ njb-56 75 16     SPACE njb-56 75 17 sample sample NOUN njb-56 75 18     SPACE njb-56 75 19 in in ADP njb-56 75 20     SPACE njb-56 75 21 a a DET njb-56 75 22     SPACE njb-56 75 23 0.8 0.8 NUM njb-56 75 24 % % NOUN njb-56 75 25     SPACE njb-56 75 26 agarose agarose NOUN njb-56 75 27     SPACE njb-56 75 28 gel gel NOUN njb-56 75 29 . . PUNCT njb-56 75 30     SPACE njb-56 76 1 020‐024 020‐024 NUM njb-56 76 2     SPACE njb-56 76 3 are be AUX njb-56 76 4     SPACE njb-56 76 5 the the DET njb-56 76 6     SPACE njb-56 76 7 dna dna NOUN njb-56 76 8     SPACE njb-56 76 9 samples sample NOUN njb-56 76 10 , , PUNCT njb-56 76 11     SPACE njb-56 76 12 pc pc NOUN njb-56 76 13     SPACE njb-56 76 14 is be AUX njb-56 76 15     SPACE njb-56 76 16 the the DET njb-56 76 17     SPACE njb-56 76 18 positive positive ADJ njb-56 76 19     SPACE njb-56 76 20 control control NOUN njb-56 76 21     SPACE njb-56 76 22 and and CCONJ njb-56 76 23     SPACE njb-56 76 24 nc nc PROPN njb-56 76 25     SPACE njb-56 76 26 is be AUX njb-56 76 27     SPACE njb-56 76 28 the the DET njb-56 76 29     SPACE njb-56 76 30 negative negative ADJ njb-56 76 31     SPACE njb-56 76 32 control control NOUN njb-56 76 33 . . PUNCT njb-56 76 34     SPACE njb-56 77 1 the the DET njb-56 77 2     SPACE njb-56 77 3 bands band NOUN njb-56 77 4     SPACE njb-56 77 5 are be AUX njb-56 77 6     SPACE njb-56 77 7 very very ADV njb-56 77 8     SPACE njb-56 77 9 close close ADJ njb-56 77 10     SPACE njb-56 77 11 to to ADP njb-56 77 12     SPACE njb-56 77 13 the the DET njb-56 77 14     SPACE njb-56 77 15 loading loading NOUN njb-56 77 16     SPACE njb-56 77 17 well well ADV njb-56 77 18     SPACE njb-56 77 19 indicating indicate VERB njb-56 77 20     SPACE njb-56 77 21 the the DET njb-56 77 22     SPACE njb-56 77 23 larger large ADJ njb-56 77 24     SPACE njb-56 77 25 fragment fragment NOUN njb-56 77 26     SPACE njb-56 77 27 of of ADP njb-56 77 28     SPACE njb-56 77 29 genomic genomic ADJ njb-56 77 30     SPACE njb-56 77 31 dna dna PROPN njb-56 77 32 . . PUNCT njb-56 77 33     SPACE njb-56 78 1 figure figure VERB njb-56 78 2     SPACE njb-56 78 3 4 4 NUM njb-56 78 4 . . PUNCT njb-56 78 5     SPACE njb-56 79 1 visualization visualization NOUN njb-56 79 2     SPACE njb-56 79 3 of of ADP njb-56 79 4     SPACE njb-56 79 5 the the DET njb-56 79 6     SPACE njb-56 79 7 extracted extract VERB njb-56 79 8     SPACE njb-56 79 9 dna dna NOUN njb-56 79 10     SPACE njb-56 79 11 sample sample NOUN njb-56 79 12     SPACE njb-56 79 13 from from ADP njb-56 79 14     SPACE njb-56 79 15 human human ADJ njb-56 79 16     SPACE njb-56 79 17 whole whole ADJ njb-56 79 18     SPACE njb-56 79 19 blood blood NOUN njb-56 79 20     SPACE njb-56 79 21 in in ADP njb-56 79 22     SPACE njb-56 79 23 a a DET njb-56 79 24     SPACE njb-56 79 25 0.8 0.8 NUM njb-56 79 26 % % NOUN njb-56 79 27     SPACE njb-56 79 28 agarose agarose NOUN njb-56 79 29     SPACE njb-56 79 30 gel gel NOUN njb-56 79 31 . . PUNCT njb-56 79 32     SPACE njb-56 80 1 001‐005 001‐005 PROPN njb-56 80 2     SPACE njb-56 80 3 are be AUX njb-56 80 4     SPACE njb-56 80 5 the the DET njb-56 80 6     SPACE njb-56 80 7 dna dna NOUN njb-56 80 8     SPACE njb-56 80 9 samples sample NOUN njb-56 80 10 , , PUNCT njb-56 80 11     SPACE njb-56 80 12 pc pc NOUN njb-56 80 13     SPACE njb-56 80 14 is be AUX njb-56 80 15     SPACE njb-56 80 16 the the DET njb-56 80 17     SPACE njb-56 80 18 positive positive ADJ njb-56 80 19     SPACE njb-56 80 20 control control NOUN njb-56 80 21     SPACE njb-56 80 22 and and CCONJ njb-56 80 23     SPACE njb-56 80 24 nc nc PROPN njb-56 80 25     SPACE njb-56 80 26 is be AUX njb-56 80 27     SPACE njb-56 80 28 the the DET njb-56 80 29     SPACE njb-56 80 30 negative negative ADJ njb-56 80 31     SPACE njb-56 80 32 control control NOUN njb-56 80 33 . . PUNCT njb-56 80 34     SPACE njb-56 81 1 the the DET njb-56 81 2     SPACE njb-56 81 3 bands band NOUN njb-56 81 4     SPACE njb-56 81 5 are be AUX njb-56 81 6     SPACE njb-56 81 7 very very ADV njb-56 81 8     SPACE njb-56 81 9 close close NOUN njb-56 81 10     SPACE njb-56 81 11 to to ADP njb-56 81 12     SPACE njb-56 81 13 the the DET njb-56 81 14     SPACE njb-56 81 15 loading loading NOUN njb-56 81 16     SPACE njb-56 81 17 well well ADV njb-56 81 18     SPACE njb-56 81 19 indicating indicate VERB njb-56 81 20     SPACE njb-56 81 21 the the DET njb-56 81 22     SPACE njb-56 81 23 larger large ADJ njb-56 81 24     SPACE njb-56 81 25 fragment fragment NOUN njb-56 81 26     SPACE njb-56 81 27 of of ADP njb-56 81 28     SPACE njb-56 81 29 genomic genomic ADJ njb-56 81 30     SPACE njb-56 81 31 dna dna PROPN njb-56 81 32 . . PUNCT njb-56 81 33     SPACE njb-56 81 34 nepal nepal ADJ njb-56 81 35     SPACE njb-56 81 36 journal journal NOUN njb-56 81 37     SPACE njb-56 81 38 of of ADP njb-56 81 39     SPACE njb-56 81 40 biotechnology biotechnology NOUN njb-56 81 41 . . PUNCT njb-56 81 42     SPACE njb-56 82 1 jan jan PROPN njb-56 82 2 . . PROPN njb-56 82 3     SPACE njb-56 82 4 2011 2011 NUM njb-56 82 5 , , PUNCT njb-56 82 6     SPACE njb-56 82 7 vol vol NOUN njb-56 82 8 . . PUNCT njb-56 82 9     SPACE njb-56 82 10 1 1 NUM njb-56 82 11 , , PUNCT njb-56 82 12     SPACE njb-56 82 13 no no INTJ njb-56 82 14 . . PUNCT njb-56 82 15     SPACE njb-56 83 1 1 1 X njb-56 83 2     SPACE njb-56 83 3 : : PUNCT njb-56 83 4     SPACE njb-56 83 5 14‐21 14‐21 NUM njb-56 83 6     SPACE njb-56 83 7 18 18 NUM njb-56 83 8       SPACE njb-56 83 9 biotechnology biotechnology NOUN njb-56 83 10     SPACE njb-56 83 11 society society NOUN njb-56 83 12     SPACE njb-56 83 13 of of ADP njb-56 83 14     SPACE njb-56 83 15 nepal nepal NOUN njb-56 83 16     SPACE njb-56 83 17 ( ( PUNCT njb-56 83 18 bsn bsn PROPN njb-56 83 19 ) ) PUNCT njb-56 83 20 , , PUNCT njb-56 83 21     SPACE njb-56 83 22 all all DET njb-56 83 23     SPACE njb-56 83 24 rights right NOUN njb-56 83 25     SPACE njb-56 83 26 reserved reserve VERB njb-56 83 27       SPACE njb-56 83 28 figure figure NOUN njb-56 83 29     SPACE njb-56 83 30 5 5 NUM njb-56 83 31 . . PUNCT njb-56 83 32     SPACE njb-56 83 33 pcr pcr DET njb-56 83 34     SPACE njb-56 83 35 product product NOUN njb-56 83 36     SPACE njb-56 83 37 of of ADP njb-56 83 38     SPACE njb-56 83 39 katg katg PROPN njb-56 83 40     SPACE njb-56 83 41 gene gene NOUN njb-56 83 42     SPACE njb-56 83 43 fragment fragment NOUN njb-56 83 44     SPACE njb-56 83 45 visualized visualize VERB njb-56 83 46     SPACE njb-56 83 47 in in ADP njb-56 83 48     SPACE njb-56 83 49 a a DET njb-56 83 50     SPACE njb-56 83 51 2 2 NUM njb-56 83 52 % % NOUN njb-56 83 53     SPACE njb-56 83 54 agarose agarose NOUN njb-56 83 55     SPACE njb-56 83 56 gel gel NOUN njb-56 83 57 . . PUNCT njb-56 83 58     SPACE njb-56 84 1 020‐024 020‐024 NUM njb-56 84 2     SPACE njb-56 84 3 are be AUX njb-56 84 4     SPACE njb-56 84 5 the the DET njb-56 84 6     SPACE njb-56 84 7 mtb mtb NOUN njb-56 84 8     SPACE njb-56 84 9 samples sample NOUN njb-56 84 10 , , PUNCT njb-56 84 11     SPACE njb-56 84 12 pc pc NOUN njb-56 84 13     SPACE njb-56 84 14 is be AUX njb-56 84 15     SPACE njb-56 84 16 the the DET njb-56 84 17     SPACE njb-56 84 18 positive positive ADJ njb-56 84 19     SPACE njb-56 84 20 control control NOUN njb-56 84 21     SPACE njb-56 84 22 and and CCONJ njb-56 84 23     SPACE njb-56 84 24 ntc ntc PROPN njb-56 84 25     SPACE njb-56 84 26 is be AUX njb-56 84 27     SPACE njb-56 84 28 the the DET njb-56 84 29     SPACE njb-56 84 30 no no DET njb-56 84 31     SPACE njb-56 84 32 template template NOUN njb-56 84 33     SPACE njb-56 84 34 con‐ con‐ ADJ njb-56 84 35 trol trol NOUN njb-56 84 36 . . PUNCT njb-56 84 37     SPACE njb-56 84 38 all all DET njb-56 84 39     SPACE njb-56 84 40 the the DET njb-56 84 41     SPACE njb-56 84 42 samples sample NOUN njb-56 84 43     SPACE njb-56 84 44 have have VERB njb-56 84 45     SPACE njb-56 84 46 positive positive ADJ njb-56 84 47     SPACE njb-56 84 48 band band NOUN njb-56 84 49     SPACE njb-56 84 50 amplification amplification NOUN njb-56 84 51     SPACE njb-56 84 52 at at ADP njb-56 84 53     SPACE njb-56 84 54 200 200 NUM njb-56 84 55     SPACE njb-56 84 56 bp bp PROPN njb-56 84 57     SPACE njb-56 84 58 region region NOUN njb-56 84 59 . . PUNCT njb-56 84 60     SPACE njb-56 85 1 figure figure VERB njb-56 85 2     SPACE njb-56 85 3 6.mspi 6.mspi NUM njb-56 85 4     SPACE njb-56 85 5 digested digest VERB njb-56 85 6     SPACE njb-56 85 7 product product NOUN njb-56 85 8     SPACE njb-56 85 9 of of ADP njb-56 85 10     SPACE njb-56 85 11 katg katg PROPN njb-56 85 12     SPACE njb-56 85 13 gene gene NOUN njb-56 85 14     SPACE njb-56 85 15 fragment fragment ADJ njb-56 85 16     SPACE njb-56 85 17 visualized visualize VERB njb-56 85 18     SPACE njb-56 85 19 in in ADP njb-56 85 20     SPACE njb-56 85 21 a a DET njb-56 85 22     SPACE njb-56 85 23 2 2 NUM njb-56 85 24 % % NOUN njb-56 85 25     SPACE njb-56 85 26 agarose agarose NOUN njb-56 85 27     SPACE njb-56 85 28 gel gel NOUN njb-56 85 29 . . PUNCT njb-56 85 30     SPACE njb-56 86 1 020‐024 020‐024 NUM njb-56 86 2     SPACE njb-56 86 3 are be AUX njb-56 86 4     SPACE njb-56 86 5 the the DET njb-56 86 6     SPACE njb-56 86 7 mtb mtb NOUN njb-56 86 8     SPACE njb-56 86 9 samples sample NOUN njb-56 86 10 , , PUNCT njb-56 86 11     SPACE njb-56 86 12 pc pc NOUN njb-56 86 13     SPACE njb-56 86 14 is be AUX njb-56 86 15     SPACE njb-56 86 16 the the DET njb-56 86 17     SPACE njb-56 86 18 positive positive ADJ njb-56 86 19     SPACE njb-56 86 20 control control NOUN njb-56 86 21     SPACE njb-56 86 22 and and CCONJ njb-56 86 23     SPACE njb-56 86 24 ntc ntc PROPN njb-56 86 25     SPACE njb-56 86 26 is be AUX njb-56 86 27     SPACE njb-56 86 28 the the DET njb-56 86 29     SPACE njb-56 86 30 no no DET njb-56 86 31     SPACE njb-56 86 32 template template NOUN njb-56 86 33     SPACE njb-56 86 34 control control NOUN njb-56 86 35 . . PUNCT njb-56 86 36     SPACE njb-56 86 37 samples sample NOUN njb-56 86 38     SPACE njb-56 86 39 021 021 NUM njb-56 86 40 , , PUNCT njb-56 86 41     SPACE njb-56 86 42 022 022 NUM njb-56 86 43 , , PUNCT njb-56 86 44     SPACE njb-56 86 45 and and CCONJ njb-56 86 46     SPACE njb-56 86 47 023 023 NUM njb-56 86 48     SPACE njb-56 86 49 has have VERB njb-56 86 50     SPACE njb-56 86 51 a a DET njb-56 86 52     SPACE njb-56 86 53 band band NOUN njb-56 86 54     SPACE njb-56 86 55 size size NOUN njb-56 86 56     SPACE njb-56 86 57 of of ADP njb-56 86 58     SPACE njb-56 86 59 153 153 NUM njb-56 86 60     SPACE njb-56 86 61 bp bp PROPN njb-56 86 62     SPACE njb-56 86 63 indicating indicate VERB njb-56 86 64     SPACE njb-56 86 65 no no DET njb-56 86 66     SPACE njb-56 86 67 mutation mutation NOUN njb-56 86 68     SPACE njb-56 86 69 at at ADP njb-56 86 70     SPACE njb-56 86 71 315th 315th ADJ njb-56 86 72     SPACE njb-56 86 73 codon codon NOUN njb-56 86 74     SPACE njb-56 86 75 position position NOUN njb-56 86 76     SPACE njb-56 86 77 where where SCONJ njb-56 86 78     SPACE njb-56 86 79 as as ADP njb-56 86 80     SPACE njb-56 86 81 sample sample NOUN njb-56 86 82     SPACE njb-56 86 83 020 020 NUM njb-56 86 84     SPACE njb-56 86 85 and and CCONJ njb-56 86 86     SPACE njb-56 86 87 024 024 NUM njb-56 86 88     SPACE njb-56 86 89 has have VERB njb-56 86 90     SPACE njb-56 86 91 a a DET njb-56 86 92     SPACE njb-56 86 93 band band NOUN njb-56 86 94     SPACE njb-56 86 95 sized size VERB njb-56 86 96     SPACE njb-56 86 97 132 132 NUM njb-56 86 98     SPACE njb-56 86 99 bp bp PROPN njb-56 86 100     SPACE njb-56 86 101 indicating indicate VERB njb-56 86 102     SPACE njb-56 86 103 seràthr seràthr PROPN njb-56 86 104     SPACE njb-56 86 105 mutation mutation NOUN njb-56 86 106     SPACE njb-56 86 107 at at ADP njb-56 86 108     SPACE njb-56 86 109 315th 315th ADJ njb-56 86 110     SPACE njb-56 86 111 codon codon NOUN njb-56 86 112     SPACE njb-56 86 113 position position NOUN njb-56 86 114     SPACE njb-56 86 115 of of ADP njb-56 86 116     SPACE njb-56 86 117 katg katg PROPN njb-56 86 118     SPACE njb-56 86 119 gene gene NOUN njb-56 86 120 . . PUNCT njb-56 86 121     SPACE njb-56 87 1 sensitivity sensitivity NOUN njb-56 87 2     SPACE njb-56 87 3 and and CCONJ njb-56 87 4     SPACE njb-56 87 5 specificity specificity NOUN njb-56 87 6 . . PUNCT njb-56 87 7     SPACE njb-56 88 1 the the DET njb-56 88 2     SPACE njb-56 88 3 present present ADJ njb-56 88 4     SPACE njb-56 88 5 study study NOUN njb-56 88 6     SPACE njb-56 88 7 looks look VERB njb-56 88 8     SPACE njb-56 88 9 at at ADP njb-56 88 10     SPACE njb-56 88 11 the the DET njb-56 88 12     SPACE njb-56 88 13 resistance resistance NOUN njb-56 88 14     SPACE njb-56 88 15 in in ADP njb-56 88 16     SPACE njb-56 88 17 the the DET njb-56 88 18     SPACE njb-56 88 19 katg katg PROPN njb-56 88 20     SPACE njb-56 88 21 ser315thr ser315thr NOUN njb-56 88 22     SPACE njb-56 88 23 towards towards ADP njb-56 88 24     SPACE njb-56 88 25 a a DET njb-56 88 26     SPACE njb-56 88 27 popular popular ADJ njb-56 88 28     SPACE njb-56 88 29 anti‐tb anti‐tb ADP njb-56 88 30     SPACE njb-56 88 31 drug drug NOUN njb-56 88 32     SPACE njb-56 88 33 isoniazid isoniazid PROPN njb-56 88 34 . . PUNCT njb-56 88 35     SPACE njb-56 89 1 this this PRON njb-56 89 2     SPACE njb-56 89 3 is be AUX njb-56 89 4     SPACE njb-56 89 5 just just ADV njb-56 89 6     SPACE njb-56 89 7 one one NOUN njb-56 89 8     SPACE njb-56 89 9 among among ADP njb-56 89 10     SPACE njb-56 89 11 many many ADJ njb-56 89 12     SPACE njb-56 89 13 possible possible ADJ njb-56 89 14     SPACE njb-56 89 15 mutations mutation NOUN njb-56 89 16     SPACE njb-56 89 17 in in ADP njb-56 89 18     SPACE njb-56 89 19 katg katg PROPN njb-56 89 20     SPACE njb-56 89 21 accounting accounting NOUN njb-56 89 22     SPACE njb-56 89 23 for for ADP njb-56 89 24     SPACE njb-56 89 25 inh inh NOUN njb-56 89 26     SPACE njb-56 89 27 resistance resistance NOUN njb-56 89 28 . . PUNCT njb-56 89 29     SPACE njb-56 90 1 4 4 NUM njb-56 90 2     SPACE njb-56 90 3 ( ( PUNCT njb-56 90 4 16.67 16.67 NUM njb-56 90 5 % % NOUN njb-56 90 6 ) ) PUNCT njb-56 90 7     SPACE njb-56 90 8 samples sample NOUN njb-56 90 9     SPACE njb-56 90 10 molecular molecular ADJ njb-56 90 11     SPACE njb-56 90 12 diagnostic diagnostic ADJ njb-56 90 13     SPACE njb-56 90 14 tools tool NOUN njb-56 90 15     SPACE njb-56 90 16 are be AUX njb-56 90 17     SPACE njb-56 90 18 promoted promote VERB njb-56 90 19     SPACE njb-56 90 20 globally globally ADV njb-56 90 21     SPACE njb-56 90 22 mostly mostly ADV njb-56 90 23     SPACE njb-56 90 24 in in ADP njb-56 90 25     SPACE njb-56 90 26 the the DET njb-56 90 27     SPACE njb-56 90 28 detection detection NOUN njb-56 90 29     SPACE njb-56 90 30 of of ADP njb-56 90 31     SPACE njb-56 90 32 mtb mtb NOUN njb-56 90 33 , , PUNCT njb-56 90 34     SPACE njb-56 90 35 drug drug NOUN njb-56 90 36     SPACE njb-56 90 37 monitoring monitoring NOUN njb-56 90 38     SPACE njb-56 90 39 and and CCONJ njb-56 90 40     SPACE njb-56 90 41 in in ADP njb-56 90 42     SPACE njb-56 90 43 mdr‐tb mdr‐tb ADJ njb-56 90 44     SPACE njb-56 90 45 diagnosis diagnosis NOUN njb-56 90 46     SPACE njb-56 90 47 ( ( PUNCT njb-56 90 48 pai pai NOUN njb-56 90 49     SPACE njb-56 90 50 et et NOUN njb-56 90 51     SPACE njb-56 90 52 al al PROPN njb-56 90 53 . . PROPN njb-56 90 54 , , PUNCT njb-56 90 55     SPACE njb-56 90 56 2006 2006 NUM njb-56 90 57 ) ) PUNCT njb-56 90 58 . . PUNCT njb-56 90 59     SPACE njb-56 91 1 this this PRON njb-56 91 2     SPACE njb-56 91 3 is be AUX njb-56 91 4     SPACE njb-56 91 5 due due ADJ njb-56 91 6     SPACE njb-56 91 7 to to PART njb-56 91 8     SPACE njb-56 91 9 many many ADJ njb-56 91 10     SPACE njb-56 91 11 advantages advantage NOUN njb-56 91 12     SPACE njb-56 91 13 of of ADP njb-56 91 14     SPACE njb-56 91 15 molecular molecular ADJ njb-56 91 16     SPACE njb-56 91 17 genomic genomic ADJ njb-56 91 18     SPACE njb-56 91 19 tools tool NOUN njb-56 91 20     SPACE njb-56 91 21 over over ADP njb-56 91 22     SPACE njb-56 91 23 conventional conventional ADJ njb-56 91 24     SPACE njb-56 91 25 diagnostic diagnostic ADJ njb-56 91 26     SPACE njb-56 91 27 methods method NOUN njb-56 91 28     SPACE njb-56 91 29 that that PRON njb-56 91 30     SPACE njb-56 91 31 lack lack VERB njb-56 91 32     SPACE njb-56 91 33 the the DET njb-56 91 34     SPACE njb-56 91 35 speed speed NOUN njb-56 91 36 , , PUNCT njb-56 91 37     SPACE njb-56 91 38 figure figure NOUN njb-56 91 39     SPACE njb-56 91 40 7 7 NUM njb-56 91 41 . . PUNCT njb-56 91 42     SPACE njb-56 91 43 pcr pcr DET njb-56 91 44     SPACE njb-56 91 45 product product NOUN njb-56 91 46     SPACE njb-56 91 47 of of ADP njb-56 91 48     SPACE njb-56 91 49 int4 int4 PROPN njb-56 91 50     SPACE njb-56 91 51 gene gene NOUN njb-56 91 52     SPACE njb-56 91 53 fragment fragment NOUN njb-56 91 54     SPACE njb-56 91 55 visualized visualize VERB njb-56 91 56     SPACE njb-56 91 57 in in ADP njb-56 91 58     SPACE njb-56 91 59 a a DET njb-56 91 60     SPACE njb-56 91 61 2 2 NUM njb-56 91 62 % % NOUN njb-56 91 63     SPACE njb-56 91 64 agarose agarose NOUN njb-56 91 65     SPACE njb-56 91 66 gel gel NOUN njb-56 91 67 . . PUNCT njb-56 91 68     SPACE njb-56 92 1 001‐005 001‐005 PROPN njb-56 92 2     SPACE njb-56 92 3 are be AUX njb-56 92 4     SPACE njb-56 92 5 the the DET njb-56 92 6     SPACE njb-56 92 7 human human ADJ njb-56 92 8     SPACE njb-56 92 9 dna dna NOUN njb-56 92 10     SPACE njb-56 92 11 samples sample NOUN njb-56 92 12 , , PUNCT njb-56 92 13     SPACE njb-56 92 14 pc pc NOUN njb-56 92 15     SPACE njb-56 92 16 is be AUX njb-56 92 17     SPACE njb-56 92 18 the the DET njb-56 92 19     SPACE njb-56 92 20 positive positive ADJ njb-56 92 21     SPACE njb-56 92 22 control control NOUN njb-56 92 23     SPACE njb-56 92 24 and and CCONJ njb-56 92 25     SPACE njb-56 92 26 ntc ntc PROPN njb-56 92 27     SPACE njb-56 92 28 is be AUX njb-56 92 29     SPACE njb-56 92 30 the the DET njb-56 92 31     SPACE njb-56 92 32 no no DET njb-56 92 33     SPACE njb-56 92 34 template template NOUN njb-56 92 35     SPACE njb-56 92 36 control control NOUN njb-56 92 37 . . PUNCT njb-56 92 38     SPACE njb-56 92 39 all all DET njb-56 92 40     SPACE njb-56 92 41 the the DET njb-56 92 42     SPACE njb-56 92 43 samples sample NOUN njb-56 92 44     SPACE njb-56 92 45 has have VERB njb-56 92 46     SPACE njb-56 92 47 positive positive ADJ njb-56 92 48     SPACE njb-56 92 49 band band NOUN njb-56 92 50     SPACE njb-56 92 51 amplification amplification NOUN njb-56 92 52     SPACE njb-56 92 53 at at ADP njb-56 92 54     SPACE njb-56 92 55 514 514 NUM njb-56 92 56     SPACE njb-56 92 57 bp bp PROPN njb-56 92 58     SPACE njb-56 92 59 region region NOUN njb-56 92 60     SPACE njb-56 92 61 figure figure NOUN njb-56 92 62     SPACE njb-56 92 63 8 8 NUM njb-56 92 64 . . PUNCT njb-56 92 65     SPACE njb-56 92 66 apai apai NOUN njb-56 92 67     SPACE njb-56 92 68 digested digest VERB njb-56 92 69     SPACE njb-56 92 70 product product NOUN njb-56 92 71     SPACE njb-56 92 72 of of ADP njb-56 92 73     SPACE njb-56 92 74 int4 int4 PROPN njb-56 92 75     SPACE njb-56 92 76 gene gene NOUN njb-56 92 77     SPACE njb-56 92 78 fragment fragment ADJ njb-56 92 79     SPACE njb-56 92 80 visualized visualize VERB njb-56 92 81     SPACE njb-56 92 82 in in ADP njb-56 92 83     SPACE njb-56 92 84 a a DET njb-56 92 85     SPACE njb-56 92 86 2 2 NUM njb-56 92 87 % % NOUN njb-56 92 88     SPACE njb-56 92 89 agarose agarose NOUN njb-56 92 90     SPACE njb-56 92 91 gel gel NOUN njb-56 92 92 . . PUNCT njb-56 92 93     SPACE njb-56 92 94 001‐002 001‐002 PROPN njb-56 92 95     SPACE njb-56 92 96 are be AUX njb-56 92 97     SPACE njb-56 92 98 the the DET njb-56 92 99     SPACE njb-56 92 100 human human ADJ njb-56 92 101     SPACE njb-56 92 102 dna dna PROPN njb-56 92 103     SPACE njb-56 92 104 samples sample NOUN njb-56 92 105 , , PUNCT njb-56 92 106     SPACE njb-56 92 107 pc pc NOUN njb-56 92 108     SPACE njb-56 92 109 is be AUX njb-56 92 110     SPACE njb-56 92 111 the the DET njb-56 92 112     SPACE njb-56 92 113 positive positive ADJ njb-56 92 114     SPACE njb-56 92 115 control control NOUN njb-56 92 116     SPACE njb-56 92 117 and and CCONJ njb-56 92 118     SPACE njb-56 92 119 ntc ntc PROPN njb-56 92 120     SPACE njb-56 92 121 is be AUX njb-56 92 122     SPACE njb-56 92 123 the the DET njb-56 92 124     SPACE njb-56 92 125 no no DET njb-56 92 126     SPACE njb-56 92 127 template template NOUN njb-56 92 128     SPACE njb-56 92 129 control control NOUN njb-56 92 130 . . PUNCT njb-56 92 131     SPACE njb-56 92 132 all all DET njb-56 92 133     SPACE njb-56 92 134 the the DET njb-56 92 135     SPACE njb-56 92 136 samples sample NOUN njb-56 92 137     SPACE njb-56 92 138 were be AUX njb-56 92 139     SPACE njb-56 92 140 observed observe VERB njb-56 92 141     SPACE njb-56 92 142 at at ADP njb-56 92 143     SPACE njb-56 92 144 514 514 NUM njb-56 92 145     SPACE njb-56 92 146 bp bp PROPN njb-56 92 147     SPACE njb-56 92 148 region region NOUN njb-56 92 149     SPACE njb-56 92 150 indicating indicate VERB njb-56 92 151     SPACE njb-56 92 152 no no ADV njb-56 92 153     SPACE njb-56 92 154 g g NOUN njb-56 92 155 / / SYM njb-56 92 156 c c NOUN njb-56 92 157     SPACE njb-56 92 158 polymorphisms polymorphism NOUN njb-56 92 159     SPACE njb-56 92 160 in in ADP njb-56 92 161     SPACE njb-56 92 162 int4 int4 PROPN njb-56 92 163     SPACE njb-56 92 164 region region NOUN njb-56 92 165     SPACE njb-56 92 166 of of ADP njb-56 92 167     SPACE njb-56 92 168 slc11a1 slc11a1 NOUN njb-56 92 169     SPACE njb-56 92 170 gene gene NOUN njb-56 92 171     SPACE njb-56 92 172 nepal nepal ADJ njb-56 92 173     SPACE njb-56 92 174 journal journal NOUN njb-56 92 175     SPACE njb-56 92 176 of of ADP njb-56 92 177     SPACE njb-56 92 178 biotechnology biotechnology NOUN njb-56 92 179 . . PUNCT njb-56 92 180     SPACE njb-56 93 1 jan jan PROPN njb-56 93 2 . . PROPN njb-56 93 3     SPACE njb-56 93 4 2011 2011 NUM njb-56 93 5 , , PUNCT njb-56 93 6     SPACE njb-56 93 7 vol vol NOUN njb-56 93 8 . . PUNCT njb-56 93 9     SPACE njb-56 93 10 1 1 NUM njb-56 93 11 , , PUNCT njb-56 93 12     SPACE njb-56 93 13 no no INTJ njb-56 93 14 . . PUNCT njb-56 93 15     SPACE njb-56 94 1 1 1 X njb-56 94 2     SPACE njb-56 94 3 : : PUNCT njb-56 94 4     SPACE njb-56 94 5 14‐21 14‐21 NUM njb-56 94 6     SPACE njb-56 94 7 19 19 NUM njb-56 94 8       SPACE njb-56 94 9 biotechnology biotechnology NOUN njb-56 94 10     SPACE njb-56 94 11 society society NOUN njb-56 94 12     SPACE njb-56 94 13 of of ADP njb-56 94 14     SPACE njb-56 94 15 nepal nepal NOUN njb-56 94 16     SPACE njb-56 94 17 ( ( PUNCT njb-56 94 18 bsn bsn PROPN njb-56 94 19 ) ) PUNCT njb-56 94 20 , , PUNCT njb-56 94 21     SPACE njb-56 94 22 all all DET njb-56 94 23     SPACE njb-56 94 24 rights right NOUN njb-56 94 25     SPACE njb-56 94 26 reserved reserve VERB njb-56 94 27       SPACE njb-56 94 28 out out ADP njb-56 94 29     SPACE njb-56 94 30 of of ADP njb-56 94 31     SPACE njb-56 94 32 24 24 NUM njb-56 94 33     SPACE njb-56 94 34 mtb mtb NOUN njb-56 94 35     SPACE njb-56 94 36 culture culture NOUN njb-56 94 37     SPACE njb-56 94 38 samples sample NOUN njb-56 94 39     SPACE njb-56 94 40 demonstrated demonstrate VERB njb-56 94 41     SPACE njb-56 94 42 ser315thr ser315thr NOUN njb-56 94 43     SPACE njb-56 94 44 katg katg PROPN njb-56 94 45     SPACE njb-56 94 46 mutation mutation PROPN njb-56 94 47     SPACE njb-56 94 48 ( ( PUNCT njb-56 94 49 i.e. i.e. X njb-56 94 50     SPACE njb-56 94 51 these these DET njb-56 94 52     SPACE njb-56 94 53 samples sample NOUN njb-56 94 54     SPACE njb-56 94 55 were be AUX njb-56 94 56     SPACE njb-56 94 57 inh inh ADJ njb-56 94 58     SPACE njb-56 94 59 resistant resistant ADJ njb-56 94 60 ) ) PUNCT njb-56 94 61 . . PUNCT njb-56 94 62     SPACE njb-56 95 1 it it PRON njb-56 95 2     SPACE njb-56 95 3 indicates indicate VERB njb-56 95 4     SPACE njb-56 95 5 that that PRON njb-56 95 6     SPACE njb-56 95 7 there there PRON njb-56 95 8     SPACE njb-56 95 9 could could AUX njb-56 95 10     SPACE njb-56 95 11 possibly possibly ADV njb-56 95 12     SPACE njb-56 95 13 be be AUX njb-56 95 14     SPACE njb-56 95 15 significantly significantly ADV njb-56 95 16     SPACE njb-56 95 17 high high ADJ njb-56 95 18     SPACE njb-56 95 19 anti‐tb anti‐tb ADP njb-56 95 20     SPACE njb-56 95 21 drug drug NOUN njb-56 95 22     SPACE njb-56 95 23 resistant resistant ADJ njb-56 95 24     SPACE njb-56 95 25 population population NOUN njb-56 95 26     SPACE njb-56 95 27 if if SCONJ njb-56 95 28     SPACE njb-56 95 29 screened screen VERB njb-56 95 30     SPACE njb-56 95 31 in in ADP njb-56 95 32     SPACE njb-56 95 33 a a DET njb-56 95 34     SPACE njb-56 95 35 larger large ADJ njb-56 95 36     SPACE njb-56 95 37 population population NOUN njb-56 95 38 . . PUNCT njb-56 95 39     SPACE njb-56 96 1 one one NOUN njb-56 96 2     SPACE njb-56 96 3 of of ADP njb-56 96 4     SPACE njb-56 96 5 the the DET njb-56 96 6     SPACE njb-56 96 7 drawbacks drawback NOUN njb-56 96 8     SPACE njb-56 96 9 of of ADP njb-56 96 10     SPACE njb-56 96 11 this this DET njb-56 96 12     SPACE njb-56 96 13 study study NOUN njb-56 96 14     SPACE njb-56 96 15 is be AUX njb-56 96 16     SPACE njb-56 96 17 that that SCONJ njb-56 96 18     SPACE njb-56 96 19 other other ADJ njb-56 96 20     SPACE njb-56 96 21 mutation mutation NOUN njb-56 96 22     SPACE njb-56 96 23 in in ADP njb-56 96 24     SPACE njb-56 96 25 various various ADJ njb-56 96 26     SPACE njb-56 96 27 genes gene NOUN njb-56 96 28     SPACE njb-56 96 29 ( ( PUNCT njb-56 96 30 inha inha NOUN njb-56 96 31 , , PUNCT njb-56 96 32     SPACE njb-56 96 33 oxyr oxyr PROPN njb-56 96 34 , , PUNCT njb-56 96 35     SPACE njb-56 96 36 ahpc ahpc PROPN njb-56 96 37 ) ) PUNCT njb-56 96 38     SPACE njb-56 96 39 that that PRON njb-56 96 40     SPACE njb-56 96 41 contributes contribute VERB njb-56 96 42     SPACE njb-56 96 43 to to ADP njb-56 96 44     SPACE njb-56 96 45 the the DET njb-56 96 46     SPACE njb-56 96 47 inh inh PROPN njb-56 96 48     SPACE njb-56 96 49 resistance resistance NOUN njb-56 96 50     SPACE njb-56 96 51 were be AUX njb-56 96 52     SPACE njb-56 96 53 not not PART njb-56 96 54     SPACE njb-56 96 55 studied study VERB njb-56 96 56 . . PUNCT njb-56 96 57     SPACE njb-56 97 1 studies study NOUN njb-56 97 2     SPACE njb-56 97 3 have have AUX njb-56 97 4     SPACE njb-56 97 5 reported report VERB njb-56 97 6     SPACE njb-56 97 7 that that SCONJ njb-56 97 8     SPACE njb-56 97 9 even even ADV njb-56 97 10     SPACE njb-56 97 11 if if SCONJ njb-56 97 12     SPACE njb-56 97 13 there there PRON njb-56 97 14     SPACE njb-56 97 15 is be AUX njb-56 97 16     SPACE njb-56 97 17 ser315ther ser315ther PROPN njb-56 97 18     SPACE njb-56 97 19 katg katg PROPN njb-56 97 20     SPACE njb-56 97 21 mutation mutation PROPN njb-56 97 22 , , PUNCT njb-56 97 23     SPACE njb-56 97 24 it it PRON njb-56 97 25     SPACE njb-56 97 26 does do AUX njb-56 97 27     SPACE njb-56 97 28 not not PART njb-56 97 29     SPACE njb-56 97 30 necessarily necessarily ADV njb-56 97 31     SPACE njb-56 97 32 account account NOUN njb-56 97 33     SPACE njb-56 97 34 to to ADP njb-56 97 35     SPACE njb-56 97 36 inh inh NOUN njb-56 97 37     SPACE njb-56 97 38 resistance resistance NOUN njb-56 97 39     SPACE njb-56 97 40 and and CCONJ njb-56 97 41     SPACE njb-56 97 42 have have VERB njb-56 97 43     SPACE njb-56 97 44 an an DET njb-56 97 45     SPACE njb-56 97 46 overall overall ADJ njb-56 97 47     SPACE njb-56 97 48 high high ADJ njb-56 97 49     SPACE njb-56 97 50 level level NOUN njb-56 97 51     SPACE njb-56 97 52 of of ADP njb-56 97 53     SPACE njb-56 97 54 catalase catalase NOUN njb-56 97 55     SPACE njb-56 97 56 activity activity NOUN njb-56 97 57     SPACE njb-56 97 58 ( ( PUNCT njb-56 97 59 guo guo PROPN njb-56 97 60     SPACE njb-56 97 61 et et PROPN njb-56 97 62     SPACE njb-56 97 63 al al PROPN njb-56 97 64 . . PROPN njb-56 97 65 , , PUNCT njb-56 97 66     SPACE njb-56 97 67 2006 2006 NUM njb-56 97 68 ) ) PUNCT njb-56 97 69 . . PUNCT njb-56 97 70     SPACE njb-56 97 71 both both DET njb-56 97 72     SPACE njb-56 97 73 the the DET njb-56 97 74     SPACE njb-56 97 75 catalase catalase NOUN njb-56 97 76     SPACE njb-56 97 77 activity activity NOUN njb-56 97 78     SPACE njb-56 97 79 and and CCONJ njb-56 97 80     SPACE njb-56 97 81 drug drug NOUN njb-56 97 82     SPACE njb-56 97 83 sensitivity sensitivity NOUN njb-56 97 84     SPACE njb-56 97 85 information information NOUN njb-56 97 86     SPACE njb-56 97 87 could could AUX njb-56 97 88     SPACE njb-56 97 89 not not PART njb-56 97 90     SPACE njb-56 97 91 be be AUX njb-56 97 92     SPACE njb-56 97 93 obtained obtain VERB njb-56 97 94 . . PUNCT njb-56 97 95       SPACE njb-56 98 1 the the DET njb-56 98 2     SPACE njb-56 98 3 association association NOUN njb-56 98 4     SPACE njb-56 98 5 between between ADP njb-56 98 6     SPACE njb-56 98 7 slc11a1 slc11a1 NOUN njb-56 98 8     SPACE njb-56 98 9 polymorphisms polymorphism NOUN njb-56 98 10     SPACE njb-56 98 11 and and CCONJ njb-56 98 12     SPACE njb-56 98 13 susceptibility susceptibility NOUN njb-56 98 14     SPACE njb-56 98 15 to to PART njb-56 98 16     SPACE njb-56 98 17 tuberculosis tuberculosis NOUN njb-56 98 18     SPACE njb-56 98 19 has have AUX njb-56 98 20     SPACE njb-56 98 21 been be AUX njb-56 98 22     SPACE njb-56 98 23 described describe VERB njb-56 98 24     SPACE njb-56 98 25 in in ADP njb-56 98 26     SPACE njb-56 98 27 many many ADJ njb-56 98 28     SPACE njb-56 98 29 studies study NOUN njb-56 98 30 , , PUNCT njb-56 98 31     SPACE njb-56 98 32 which which PRON njb-56 98 33     SPACE njb-56 98 34 showed show VERB njb-56 98 35     SPACE njb-56 98 36 positive positive ADJ njb-56 98 37     SPACE njb-56 98 38 association association NOUN njb-56 98 39     SPACE njb-56 98 40 in in ADP njb-56 98 41     SPACE njb-56 98 42 some some PRON njb-56 98 43 , , PUNCT njb-56 98 44     SPACE njb-56 98 45 while while SCONJ njb-56 98 46     SPACE njb-56 98 47 no no DET njb-56 98 48     SPACE njb-56 98 49 association association NOUN njb-56 98 50     SPACE njb-56 98 51 in in ADP njb-56 98 52     SPACE njb-56 98 53 others other NOUN njb-56 98 54     SPACE njb-56 98 55 ( ( PUNCT njb-56 98 56 takahashi takahashi PROPN njb-56 98 57     SPACE njb-56 98 58 et et PROPN njb-56 98 59     SPACE njb-56 98 60 al al PROPN njb-56 98 61 . . PROPN njb-56 98 62 , , PUNCT njb-56 98 63     SPACE njb-56 98 64 2008 2008 NUM njb-56 98 65 ) ) PUNCT njb-56 98 66 . . PUNCT njb-56 98 67     SPACE njb-56 99 1 a a DET njb-56 99 2     SPACE njb-56 99 3 study study NOUN njb-56 99 4     SPACE njb-56 99 5 showed show VERB njb-56 99 6     SPACE njb-56 99 7 that that DET njb-56 99 8     SPACE njb-56 99 9 nramp1 nramp1 NOUN njb-56 99 10     SPACE njb-56 99 11 polymorphisms polymorphism NOUN njb-56 99 12     SPACE njb-56 99 13 may may AUX njb-56 99 14     SPACE njb-56 99 15 be be AUX njb-56 99 16     SPACE njb-56 99 17 associated associate VERB njb-56 99 18     SPACE njb-56 99 19 with with ADP njb-56 99 20     SPACE njb-56 99 21 progression progression NOUN njb-56 99 22     SPACE njb-56 99 23 to to PART njb-56 99 24     SPACE njb-56 99 25 severe severe ADJ njb-56 99 26     SPACE njb-56 99 27 forms form NOUN njb-56 99 28     SPACE njb-56 99 29 of of ADP njb-56 99 30     SPACE njb-56 99 31 pulmonary pulmonary ADJ njb-56 99 32     SPACE njb-56 99 33 tuberculosis tuberculosis NOUN njb-56 99 34     SPACE njb-56 99 35 rather rather ADV njb-56 99 36     SPACE njb-56 99 37 than than ADP njb-56 99 38     SPACE njb-56 99 39 with with ADP njb-56 99 40     SPACE njb-56 99 41 susceptibility susceptibility NOUN njb-56 99 42     SPACE njb-56 99 43 to to PART njb-56 99 44     SPACE njb-56 99 45 m. m. NOUN njb-56 99 46     SPACE njb-56 99 47 tuberculosis tuberculosis NOUN njb-56 99 48     SPACE njb-56 99 49 infection infection NOUN njb-56 99 50     SPACE njb-56 99 51 ( ( PUNCT njb-56 99 52 zhang zhang PROPN njb-56 99 53     SPACE njb-56 99 54 et et PROPN njb-56 99 55     SPACE njb-56 99 56 al al PROPN njb-56 99 57 . . PROPN njb-56 99 58 , , PUNCT njb-56 99 59     SPACE njb-56 99 60 2005 2005 NUM njb-56 99 61 ) ) PUNCT njb-56 99 62 . . PUNCT njb-56 99 63     SPACE njb-56 99 64 all all DET njb-56 99 65     SPACE njb-56 99 66 the the DET njb-56 99 67     SPACE njb-56 99 68 int4 int4 PROPN njb-56 99 69     SPACE njb-56 99 70 amplicons amplicon NOUN njb-56 99 71     SPACE njb-56 99 72 when when SCONJ njb-56 99 73     SPACE njb-56 99 74 subjected subject VERB njb-56 99 75     SPACE njb-56 99 76 to to ADP njb-56 99 77     SPACE njb-56 99 78 apai apai NOUN njb-56 99 79     SPACE njb-56 99 80 digestion digestion NOUN njb-56 99 81 , , PUNCT njb-56 99 82     SPACE njb-56 99 83 bands band NOUN njb-56 99 84     SPACE njb-56 99 85 of of ADP njb-56 99 86     SPACE njb-56 99 87 514 514 NUM njb-56 99 88     SPACE njb-56 99 89 bp bp PROPN njb-56 99 90     SPACE njb-56 99 91 were be AUX njb-56 99 92     SPACE njb-56 99 93 observed observe VERB njb-56 99 94 . . PUNCT njb-56 99 95     SPACE njb-56 100 1 if if SCONJ njb-56 100 2     SPACE njb-56 100 3 the the DET njb-56 100 4     SPACE njb-56 100 5 int4 int4 PROPN njb-56 100 6     SPACE njb-56 100 7 region region NOUN njb-56 100 8     SPACE njb-56 100 9 had have VERB njb-56 100 10     SPACE njb-56 100 11 g g SYM njb-56 100 12 / / SYM njb-56 100 13 c c NOUN njb-56 100 14     SPACE njb-56 100 15 polymorphisms polymorphism NOUN njb-56 100 16     SPACE njb-56 100 17 then then ADV njb-56 100 18     SPACE njb-56 100 19 restriction restriction NOUN njb-56 100 20     SPACE njb-56 100 21 site(s site(s NOUN njb-56 100 22 ) ) PUNCT njb-56 100 23     SPACE njb-56 100 24 would would AUX njb-56 100 25     SPACE njb-56 100 26 have have AUX njb-56 100 27     SPACE njb-56 100 28 been be AUX njb-56 100 29     SPACE njb-56 100 30 additionally additionally ADV njb-56 100 31     SPACE njb-56 100 32 created create VERB njb-56 100 33     SPACE njb-56 100 34 and and CCONJ njb-56 100 35     SPACE njb-56 100 36 the the DET njb-56 100 37     SPACE njb-56 100 38 rflp rflp NOUN njb-56 100 39     SPACE njb-56 100 40 bands band NOUN njb-56 100 41     SPACE njb-56 100 42 of of ADP njb-56 100 43     SPACE njb-56 100 44 < < X njb-56 100 45 500 500 NUM njb-56 100 46     SPACE njb-56 100 47 bp bp PROPN njb-56 100 48     SPACE njb-56 100 49 size size NOUN njb-56 100 50     SPACE njb-56 100 51 would would AUX njb-56 100 52     SPACE njb-56 100 53 have have AUX njb-56 100 54     SPACE njb-56 100 55 been be AUX njb-56 100 56     SPACE njb-56 100 57 observed observe VERB njb-56 100 58 . . PUNCT njb-56 100 59       SPACE njb-56 101 1 this this PRON njb-56 101 2     SPACE njb-56 101 3 indicates indicate VERB njb-56 101 4     SPACE njb-56 101 5 that that PRON njb-56 101 6     SPACE njb-56 101 7 no no PRON njb-56 101 8     SPACE njb-56 101 9 g g X njb-56 101 10 / / SYM njb-56 101 11 c c NOUN njb-56 101 12     SPACE njb-56 101 13 polymorphism polymorphism NOUN njb-56 101 14     SPACE njb-56 101 15 was be AUX njb-56 101 16     SPACE njb-56 101 17 present present ADJ njb-56 101 18     SPACE njb-56 101 19 in in ADP njb-56 101 20     SPACE njb-56 101 21 the the DET njb-56 101 22     SPACE njb-56 101 23 amplified amplify VERB njb-56 101 24     SPACE njb-56 101 25 figure figure NOUN njb-56 101 26     SPACE njb-56 101 27 9 9 NUM njb-56 101 28 . . PUNCT njb-56 101 29     SPACE njb-56 101 30 percentage percentage NOUN njb-56 101 31     SPACE njb-56 101 32 distribution distribution NOUN njb-56 101 33     SPACE njb-56 101 34 of of ADP njb-56 101 35     SPACE njb-56 101 36 katg katg PROPN njb-56 101 37     SPACE njb-56 101 38 ser315thr ser315thr NOUN njb-56 101 39     SPACE njb-56 101 40 mu‐ mu‐ PROPN njb-56 101 41 tation tation NOUN njb-56 101 42     SPACE njb-56 101 43 sample sample NOUN njb-56 101 44     SPACE njb-56 101 45 i i PRON njb-56 101 46 d d PROPN njb-56 101 47     SPACE njb-56 101 48 afb afb PROPN njb-56 101 49     SPACE njb-56 101 50 stain stain NOUN njb-56 101 51     SPACE njb-56 101 52 mtb mtb NOUN njb-56 101 53     SPACE njb-56 101 54 culture culture NOUN njb-56 101 55     SPACE njb-56 101 56 mdr‐tb mdr‐tb PROPN njb-56 101 57     SPACE njb-56 101 58 katg katg PROPN njb-56 101 59     SPACE njb-56 101 60 pcr pcr PROPN njb-56 101 61     SPACE njb-56 101 62 ampli‐ ampli‐ ADJ njb-56 101 63 con con NOUN njb-56 101 64     SPACE njb-56 101 65 size size NOUN njb-56 101 66     SPACE njb-56 101 67 ( ( PUNCT njb-56 101 68 bp bp PROPN njb-56 101 69 ) ) PUNCT njb-56 101 70     SPACE njb-56 101 71 mspi mspi NOUN njb-56 101 72     SPACE njb-56 101 73 digested digest VERB njb-56 101 74     SPACE njb-56 101 75 product product NOUN njb-56 101 76     SPACE njb-56 101 77 size size NOUN njb-56 101 78     SPACE njb-56 101 79 ( ( PUNCT njb-56 101 80 bp bp PROPN njb-56 101 81 ) ) PUNCT njb-56 101 82     SPACE njb-56 101 83 ser315thr ser315thr PROPN njb-56 101 84     SPACE njb-56 101 85 katg katg PROPN njb-56 101 86     SPACE njb-56 101 87 mutation mutation PROPN njb-56 101 88     SPACE njb-56 101 89 mtb‐001 mtb‐001 PROPN njb-56 101 90     SPACE njb-56 101 91 positive positive ADJ njb-56 101 92     SPACE njb-56 101 93 positive positive ADJ njb-56 101 94     SPACE njb-56 101 95 positive positive ADJ njb-56 101 96     SPACE njb-56 101 97 200 200 NUM njb-56 101 98     SPACE njb-56 101 99 153 153 NUM njb-56 101 100     SPACE njb-56 101 101 negative negative ADJ njb-56 101 102     SPACE njb-56 101 103 mtb‐002 mtb‐002 PROPN njb-56 101 104     SPACE njb-56 101 105 positive positive ADJ njb-56 101 106     SPACE njb-56 101 107 positive positive ADJ njb-56 101 108     SPACE njb-56 101 109 positive positive ADJ njb-56 101 110     SPACE njb-56 101 111 200 200 NUM njb-56 101 112     SPACE njb-56 101 113 153 153 NUM njb-56 101 114     SPACE njb-56 101 115 negative negative ADJ njb-56 101 116     SPACE njb-56 101 117 mtb‐003 mtb‐003 NOUN njb-56 101 118     SPACE njb-56 101 119 positive positive ADJ njb-56 101 120     SPACE njb-56 101 121 positive positive ADJ njb-56 101 122     SPACE njb-56 101 123 positive positive ADJ njb-56 101 124     SPACE njb-56 101 125 200 200 NUM njb-56 101 126     SPACE njb-56 101 127 153 153 NUM njb-56 101 128     SPACE njb-56 101 129 negative negative ADJ njb-56 101 130     SPACE njb-56 101 131 mtb‐004 mtb‐004 PROPN njb-56 101 132     SPACE njb-56 101 133 positive positive ADJ njb-56 101 134     SPACE njb-56 101 135 positive positive ADJ njb-56 101 136     SPACE njb-56 101 137 positive positive ADJ njb-56 101 138     SPACE njb-56 101 139 200 200 NUM njb-56 101 140     SPACE njb-56 101 141 153 153 NUM njb-56 101 142     SPACE njb-56 101 143 negative negative ADJ njb-56 101 144     SPACE njb-56 101 145 mtb‐005 mtb‐005 PROPN njb-56 101 146     SPACE njb-56 101 147 positive positive ADJ njb-56 101 148     SPACE njb-56 101 149 positive positive ADJ njb-56 101 150     SPACE njb-56 101 151 positive positive ADJ njb-56 101 152     SPACE njb-56 101 153 200 200 NUM njb-56 101 154     SPACE njb-56 101 155 153 153 NUM njb-56 101 156     SPACE njb-56 101 157 negative negative ADJ njb-56 101 158     SPACE njb-56 101 159 mtb‐006 mtb‐006 NOUN njb-56 101 160     SPACE njb-56 101 161 positive positive ADJ njb-56 101 162     SPACE njb-56 101 163 positive positive ADJ njb-56 101 164     SPACE njb-56 101 165 positive positive ADJ njb-56 101 166     SPACE njb-56 101 167 200 200 NUM njb-56 101 168     SPACE njb-56 101 169 153 153 NUM njb-56 101 170     SPACE njb-56 101 171 negative negative ADJ njb-56 101 172     SPACE njb-56 101 173 mtb‐007 mtb‐007 ADJ njb-56 101 174     SPACE njb-56 101 175 positive positive ADJ njb-56 101 176     SPACE njb-56 101 177 positive positive ADJ njb-56 101 178     SPACE njb-56 101 179 positive positive ADJ njb-56 101 180     SPACE njb-56 101 181 200 200 NUM njb-56 101 182     SPACE njb-56 101 183 153 153 NUM njb-56 101 184     SPACE njb-56 101 185 negative negative ADJ njb-56 101 186     SPACE njb-56 101 187 mtb‐008 mtb‐008 NOUN njb-56 101 188     SPACE njb-56 101 189 positive positive ADJ njb-56 101 190     SPACE njb-56 101 191 positive positive ADJ njb-56 101 192     SPACE njb-56 101 193 positive positive ADJ njb-56 101 194     SPACE njb-56 101 195 200 200 NUM njb-56 101 196     SPACE njb-56 101 197 153 153 NUM njb-56 101 198     SPACE njb-56 101 199 negative negative ADJ njb-56 101 200     SPACE njb-56 101 201 mtb‐009 mtb‐009 PROPN njb-56 101 202     SPACE njb-56 101 203 positive positive ADJ njb-56 101 204     SPACE njb-56 101 205 positive positive ADJ njb-56 101 206     SPACE njb-56 101 207 positive positive ADJ njb-56 101 208     SPACE njb-56 101 209 200 200 NUM njb-56 101 210     SPACE njb-56 101 211 153 153 NUM njb-56 101 212     SPACE njb-56 101 213 negative negative ADJ njb-56 101 214     SPACE njb-56 101 215 mtb‐010 mtb‐010 PROPN njb-56 101 216     SPACE njb-56 101 217 positive positive ADJ njb-56 101 218     SPACE njb-56 101 219 positive positive ADJ njb-56 101 220     SPACE njb-56 101 221 positive positive ADJ njb-56 101 222     SPACE njb-56 101 223 200 200 NUM njb-56 101 224     SPACE njb-56 101 225 153 153 NUM njb-56 101 226     SPACE njb-56 101 227 negative negative ADJ njb-56 101 228     SPACE njb-56 101 229 mtb‐011 mtb‐011 ADJ njb-56 101 230     SPACE njb-56 101 231 positive positive ADJ njb-56 101 232     SPACE njb-56 101 233 positive positive ADJ njb-56 101 234     SPACE njb-56 101 235 positive positive ADJ njb-56 101 236     SPACE njb-56 101 237 200 200 NUM njb-56 101 238     SPACE njb-56 101 239 153 153 NUM njb-56 101 240     SPACE njb-56 101 241 negative negative ADJ njb-56 101 242     SPACE njb-56 101 243 mtb‐012 mtb‐012 NOUN njb-56 101 244     SPACE njb-56 101 245 positive positive ADJ njb-56 101 246     SPACE njb-56 101 247 positive positive ADJ njb-56 101 248     SPACE njb-56 101 249 positive positive ADJ njb-56 101 250     SPACE njb-56 101 251 200 200 NUM njb-56 101 252     SPACE njb-56 101 253 153 153 NUM njb-56 101 254     SPACE njb-56 101 255 negative negative ADJ njb-56 101 256     SPACE njb-56 101 257 mtb‐013 mtb‐013 PROPN njb-56 101 258     SPACE njb-56 101 259 positive positive ADJ njb-56 101 260     SPACE njb-56 101 261 positive positive ADJ njb-56 101 262     SPACE njb-56 101 263 positive positive ADJ njb-56 101 264     SPACE njb-56 101 265 200 200 NUM njb-56 101 266     SPACE njb-56 101 267 153 153 NUM njb-56 101 268     SPACE njb-56 101 269 negative negative ADJ njb-56 101 270     SPACE njb-56 101 271 mtb‐014 mtb‐014 PROPN njb-56 101 272     SPACE njb-56 101 273 positive positive ADJ njb-56 101 274     SPACE njb-56 101 275 positive positive ADJ njb-56 101 276     SPACE njb-56 101 277 positive positive ADJ njb-56 101 278     SPACE njb-56 101 279 200 200 NUM njb-56 101 280     SPACE njb-56 101 281 153 153 NUM njb-56 101 282     SPACE njb-56 101 283 negative negative ADJ njb-56 101 284     SPACE njb-56 101 285 mtb‐015 mtb‐015 VERB njb-56 101 286     SPACE njb-56 101 287 positive positive ADJ njb-56 101 288     SPACE njb-56 101 289 positive positive ADJ njb-56 101 290     SPACE njb-56 101 291 positive positive ADJ njb-56 101 292     SPACE njb-56 101 293 200 200 NUM njb-56 101 294     SPACE njb-56 101 295 132 132 NUM njb-56 101 296     SPACE njb-56 101 297 positive positive ADJ njb-56 101 298     SPACE njb-56 101 299 mtb‐016 mtb‐016 PROPN njb-56 101 300     SPACE njb-56 101 301 positive positive ADJ njb-56 101 302     SPACE njb-56 101 303 positive positive ADJ njb-56 101 304     SPACE njb-56 101 305 positive positive ADJ njb-56 101 306     SPACE njb-56 101 307 200 200 NUM njb-56 101 308     SPACE njb-56 101 309 132 132 NUM njb-56 101 310     SPACE njb-56 101 311 positive positive ADJ njb-56 101 312     SPACE njb-56 101 313 mtb‐017 mtb‐017 NOUN njb-56 101 314     SPACE njb-56 101 315 positive positive ADJ njb-56 101 316     SPACE njb-56 101 317 positive positive ADJ njb-56 101 318     SPACE njb-56 101 319 positive positive ADJ njb-56 101 320     SPACE njb-56 101 321 200 200 NUM njb-56 101 322     SPACE njb-56 101 323 153 153 NUM njb-56 101 324     SPACE njb-56 101 325 negative negative ADJ njb-56 101 326     SPACE njb-56 101 327 mtb‐018 mtb‐018 NOUN njb-56 101 328     SPACE njb-56 101 329 positive positive ADJ njb-56 101 330     SPACE njb-56 101 331 positive positive ADJ njb-56 101 332     SPACE njb-56 101 333 positive positive ADJ njb-56 101 334     SPACE njb-56 101 335 200 200 NUM njb-56 101 336     SPACE njb-56 101 337 153 153 NUM njb-56 101 338     SPACE njb-56 101 339 negative negative ADJ njb-56 101 340     SPACE njb-56 101 341 mtb‐019 mtb‐019 PROPN njb-56 101 342     SPACE njb-56 101 343 positive positive ADJ njb-56 101 344     SPACE njb-56 101 345 positive positive ADJ njb-56 101 346     SPACE njb-56 101 347 positive positive ADJ njb-56 101 348     SPACE njb-56 101 349 200 200 NUM njb-56 101 350     SPACE njb-56 101 351 153 153 NUM njb-56 101 352     SPACE njb-56 101 353 negative negative ADJ njb-56 101 354     SPACE njb-56 101 355 mtb‐020 mtb‐020 PROPN njb-56 101 356     SPACE njb-56 101 357 positive positive ADJ njb-56 101 358     SPACE njb-56 101 359 positive positive ADJ njb-56 101 360     SPACE njb-56 101 361 positive positive ADJ njb-56 101 362     SPACE njb-56 101 363 200 200 NUM njb-56 101 364     SPACE njb-56 101 365 132 132 NUM njb-56 101 366     SPACE njb-56 101 367 positive positive ADJ njb-56 101 368     SPACE njb-56 101 369 mtb‐021 mtb‐021 PROPN njb-56 101 370     SPACE njb-56 101 371 positive positive ADJ njb-56 101 372     SPACE njb-56 101 373 positive positive ADJ njb-56 101 374     SPACE njb-56 101 375 positive positive ADJ njb-56 101 376     SPACE njb-56 101 377 200 200 NUM njb-56 101 378     SPACE njb-56 101 379 153 153 NUM njb-56 101 380     SPACE njb-56 101 381 negative negative ADJ njb-56 101 382     SPACE njb-56 101 383 mtb‐022 mtb‐022 NOUN njb-56 101 384     SPACE njb-56 101 385 positive positive ADJ njb-56 101 386     SPACE njb-56 101 387 positive positive ADJ njb-56 101 388     SPACE njb-56 101 389 positive positive ADJ njb-56 101 390     SPACE njb-56 101 391 200 200 NUM njb-56 101 392     SPACE njb-56 101 393 153 153 NUM njb-56 101 394     SPACE njb-56 101 395 negative negative ADJ njb-56 101 396     SPACE njb-56 101 397 mtb‐023 mtb‐023 PROPN njb-56 101 398     SPACE njb-56 101 399 positive positive ADJ njb-56 101 400     SPACE njb-56 101 401 positive positive ADJ njb-56 101 402     SPACE njb-56 101 403 positive positive ADJ njb-56 101 404     SPACE njb-56 101 405 200 200 NUM njb-56 101 406     SPACE njb-56 101 407 153 153 NUM njb-56 101 408     SPACE njb-56 101 409 negative negative ADJ njb-56 101 410     SPACE njb-56 101 411 mtb‐024 mtb‐024 ADJ njb-56 101 412     SPACE njb-56 101 413 positive positive ADJ njb-56 101 414     SPACE njb-56 101 415 positive positive ADJ njb-56 101 416     SPACE njb-56 101 417 positive positive ADJ njb-56 101 418     SPACE njb-56 101 419 200 200 NUM njb-56 101 420     SPACE njb-56 101 421 132 132 NUM njb-56 101 422     SPACE njb-56 101 423 positive positive ADJ njb-56 101 424     SPACE njb-56 101 425 table table NOUN njb-56 101 426     SPACE njb-56 101 427 2 2 NUM njb-56 101 428 . . PUNCT njb-56 101 429     SPACE njb-56 101 430 relationship relationship NOUN njb-56 101 431     SPACE njb-56 101 432 between between ADP njb-56 101 433     SPACE njb-56 101 434 afb afb NOUN njb-56 101 435     SPACE njb-56 101 436 stain stain NOUN njb-56 101 437 , , PUNCT njb-56 101 438     SPACE njb-56 101 439 mtb mtb NOUN njb-56 101 440     SPACE njb-56 101 441 culture culture NOUN njb-56 101 442     SPACE njb-56 101 443 and and CCONJ njb-56 101 444     SPACE njb-56 101 445 pcr‐rflp pcr‐rflp PROPN njb-56 101 446     SPACE njb-56 101 447 results result VERB njb-56 101 448     SPACE njb-56 101 449 nepal nepal ADJ njb-56 101 450     SPACE njb-56 101 451 journal journal NOUN njb-56 101 452     SPACE njb-56 101 453 of of ADP njb-56 101 454     SPACE njb-56 101 455 biotechnology biotechnology NOUN njb-56 101 456 . . PUNCT njb-56 101 457     SPACE njb-56 102 1 jan jan PROPN njb-56 102 2 . . PROPN njb-56 102 3     SPACE njb-56 102 4 2011 2011 NUM njb-56 102 5 , , PUNCT njb-56 102 6     SPACE njb-56 102 7 vol vol NOUN njb-56 102 8 . . PUNCT njb-56 102 9     SPACE njb-56 102 10 1 1 NUM njb-56 102 11 , , PUNCT njb-56 102 12     SPACE njb-56 102 13 no no INTJ njb-56 102 14 . . PUNCT njb-56 102 15     SPACE njb-56 103 1 1 1 X njb-56 103 2     SPACE njb-56 103 3 : : PUNCT njb-56 103 4     SPACE njb-56 103 5 14‐21 14‐21 NUM njb-56 103 6     SPACE njb-56 103 7 20 20 NUM njb-56 103 8       SPACE njb-56 103 9 biotechnology biotechnology NOUN njb-56 103 10     SPACE njb-56 103 11 society society NOUN njb-56 103 12     SPACE njb-56 103 13 of of ADP njb-56 103 14     SPACE njb-56 103 15 nepal nepal NOUN njb-56 103 16     SPACE njb-56 103 17 ( ( PUNCT njb-56 103 18 bsn bsn PROPN njb-56 103 19 ) ) PUNCT njb-56 103 20 , , PUNCT njb-56 103 21     SPACE njb-56 103 22 all all DET njb-56 103 23     SPACE njb-56 103 24 rights right NOUN njb-56 103 25     SPACE njb-56 103 26 reserved reserve VERB njb-56 103 27       SPACE njb-56 103 28 region region NOUN njb-56 103 29     SPACE njb-56 103 30 of of ADP njb-56 103 31     SPACE njb-56 103 32 int4 int4 PROPN njb-56 103 33 . . PUNCT njb-56 103 34     SPACE njb-56 104 1 the the DET njb-56 104 2     SPACE njb-56 104 3 present present ADJ njb-56 104 4     SPACE njb-56 104 5 study study NOUN njb-56 104 6     SPACE njb-56 104 7 shows show VERB njb-56 104 8     SPACE njb-56 104 9 no no DET njb-56 104 10     SPACE njb-56 104 11 significant significant ADJ njb-56 104 12     SPACE njb-56 104 13 association association NOUN njb-56 104 14     SPACE njb-56 104 15 between between ADP njb-56 104 16     SPACE njb-56 104 17 g g X njb-56 104 18 / / SYM njb-56 104 19 c c NOUN njb-56 104 20     SPACE njb-56 104 21 polymorphism polymorphism NOUN njb-56 104 22     SPACE njb-56 104 23 int4 int4 PROPN njb-56 104 24     SPACE njb-56 104 25 region region NOUN njb-56 104 26     SPACE njb-56 104 27 of of ADP njb-56 104 28     SPACE njb-56 104 29 slc11a1 slc11a1 ADP njb-56 104 30     SPACE njb-56 104 31 with with ADP njb-56 104 32     SPACE njb-56 104 33 tb tb PROPN njb-56 104 34 . . PUNCT njb-56 104 35     SPACE njb-56 105 1 with with ADP njb-56 105 2     SPACE njb-56 105 3 the the DET njb-56 105 4     SPACE njb-56 105 5 limited limited ADJ njb-56 105 6     SPACE njb-56 105 7 number number NOUN njb-56 105 8     SPACE njb-56 105 9 of of ADP njb-56 105 10     SPACE njb-56 105 11 samples sample NOUN njb-56 105 12     SPACE njb-56 105 13 and and CCONJ njb-56 105 14     SPACE njb-56 105 15 failure failure NOUN njb-56 105 16     SPACE njb-56 105 17 to to PART njb-56 105 18     SPACE njb-56 105 19 study study VERB njb-56 105 20     SPACE njb-56 105 21 d543n d543n PROPN njb-56 105 22     SPACE njb-56 105 23 and and CCONJ njb-56 105 24     SPACE njb-56 105 25 3’utr 3’utr NUM njb-56 105 26     SPACE njb-56 105 27 region region NOUN njb-56 105 28 , , PUNCT njb-56 105 29     SPACE njb-56 105 30 the the DET njb-56 105 31     SPACE njb-56 105 32 role role NOUN njb-56 105 33     SPACE njb-56 105 34 of of ADP njb-56 105 35     SPACE njb-56 105 36 slc11a1 slc11a1 NOUN njb-56 105 37     SPACE njb-56 105 38 in in ADP njb-56 105 39     SPACE njb-56 105 40 susceptibility susceptibility NOUN njb-56 105 41     SPACE njb-56 105 42 towards towards ADP njb-56 105 43     SPACE njb-56 105 44 tb tb PROPN njb-56 105 45     SPACE njb-56 105 46 can can AUX njb-56 105 47 not not PART njb-56 105 48     SPACE njb-56 105 49 over‐ over‐ NOUN njb-56 105 50 ruled rule VERB njb-56 105 51 . . PUNCT njb-56 105 52     SPACE njb-56 106 1 as as SCONJ njb-56 106 2     SPACE njb-56 106 3 who who PRON njb-56 106 4     SPACE njb-56 106 5 claims claim VERB njb-56 106 6     SPACE njb-56 106 7 one‐third one‐third NOUN njb-56 106 8     SPACE njb-56 106 9 of of ADP njb-56 106 10     SPACE njb-56 106 11 the the DET njb-56 106 12     SPACE njb-56 106 13 world world NOUN njb-56 106 14 ’s ’s PART njb-56 106 15     SPACE njb-56 106 16 population population NOUN njb-56 106 17     SPACE njb-56 106 18 to to PART njb-56 106 19     SPACE njb-56 106 20 be be AUX njb-56 106 21     SPACE njb-56 106 22 infected infect VERB njb-56 106 23     SPACE njb-56 106 24 with with ADP njb-56 106 25     SPACE njb-56 106 26 latent latent ADJ njb-56 106 27     SPACE njb-56 106 28 form form NOUN njb-56 106 29     SPACE njb-56 106 30 of of ADP njb-56 106 31     SPACE njb-56 106 32 tb tb PROPN njb-56 106 33 , , PUNCT njb-56 106 34     SPACE njb-56 106 35 slc11a1 slc11a1 NOUN njb-56 106 36     SPACE njb-56 106 37 polymorphisms polymorphism NOUN njb-56 106 38     SPACE njb-56 106 39 can can AUX njb-56 106 40     SPACE njb-56 106 41 be be AUX njb-56 106 42     SPACE njb-56 106 43 accredited accredit VERB njb-56 106 44     SPACE njb-56 106 45 to to PART njb-56 106 46     SPACE njb-56 106 47 be be AUX njb-56 106 48     SPACE njb-56 106 49 a a DET njb-56 106 50     SPACE njb-56 106 51 helping help VERB njb-56 106 52     SPACE njb-56 106 53 factor factor NOUN njb-56 106 54     SPACE njb-56 106 55 for for ADP njb-56 106 56     SPACE njb-56 106 57 tb tb PROPN njb-56 106 58     SPACE njb-56 106 59 susceptibility susceptibility NOUN njb-56 106 60     SPACE njb-56 106 61 or or CCONJ njb-56 106 62     SPACE njb-56 106 63 progression progression NOUN njb-56 106 64 . . PUNCT njb-56 106 65     SPACE njb-56 107 1 this this DET njb-56 107 2     SPACE njb-56 107 3 study study NOUN njb-56 107 4     SPACE njb-56 107 5 has have AUX njb-56 107 6     SPACE njb-56 107 7 considered consider VERB njb-56 107 8     SPACE njb-56 107 9 m. m. NOUN njb-56 107 10     SPACE njb-56 107 11 tuberculosis tuberculosis NOUN njb-56 107 12     SPACE njb-56 107 13 h37rv h37rv PROPN njb-56 107 14     SPACE njb-56 107 15 as as SCONJ njb-56 107 16     SPACE njb-56 107 17 a a DET njb-56 107 18     SPACE njb-56 107 19 reference reference NOUN njb-56 107 20     SPACE njb-56 107 21 strain strain NOUN njb-56 107 22     SPACE njb-56 107 23 but but CCONJ njb-56 107 24     SPACE njb-56 107 25 other other ADJ njb-56 107 26     SPACE njb-56 107 27 clinical clinical ADJ njb-56 107 28     SPACE njb-56 107 29 strain strain NOUN njb-56 107 30     SPACE njb-56 107 31 could could AUX njb-56 107 32     SPACE njb-56 107 33 also also ADV njb-56 107 34     SPACE njb-56 107 35 have have AUX njb-56 107 36     SPACE njb-56 107 37 been be AUX njb-56 107 38     SPACE njb-56 107 39 prevalent prevalent ADJ njb-56 107 40 . . PUNCT njb-56 107 41     SPACE njb-56 108 1 this this DET njb-56 108 2     SPACE njb-56 108 3 fact fact NOUN njb-56 108 4     SPACE njb-56 108 5 remained remain VERB njb-56 108 6     SPACE njb-56 108 7 as as ADP njb-56 108 8     SPACE njb-56 108 9 a a DET njb-56 108 10     SPACE njb-56 108 11 challenge challenge NOUN njb-56 108 12     SPACE njb-56 108 13 sampleid sampleid PROPN njb-56 108 14     SPACE njb-56 108 15 mdr‐tb mdr‐tb ADJ njb-56 108 16     SPACE njb-56 108 17 int4 int4 PROPN njb-56 108 18     SPACE njb-56 108 19 pcr pcr PROPN njb-56 108 20     SPACE njb-56 108 21 amplicon amplicon NOUN njb-56 108 22     SPACE njb-56 108 23 size size NOUN njb-56 108 24     SPACE njb-56 108 25 ( ( PUNCT njb-56 108 26 bp bp PROPN njb-56 108 27 ) ) PUNCT njb-56 108 28     SPACE njb-56 108 29 apai apai NOUN njb-56 108 30     SPACE njb-56 108 31 digested digest VERB njb-56 108 32     SPACE njb-56 108 33 product product NOUN njb-56 108 34     SPACE njb-56 108 35 of of ADP njb-56 108 36     SPACE njb-56 108 37 int4 int4 PROPN njb-56 108 38     SPACE njb-56 108 39 ( ( PUNCT njb-56 108 40 bp bp PROPN njb-56 108 41 ) ) PUNCT njb-56 108 42     SPACE njb-56 108 43 g g X njb-56 108 44 / / SYM njb-56 108 45 c c NOUN njb-56 108 46     SPACE njb-56 108 47 polymorphism polymorphism NOUN njb-56 108 48     SPACE njb-56 108 49 in in ADP njb-56 108 50     SPACE njb-56 108 51 int4 int4 PROPN njb-56 108 52     SPACE njb-56 108 53 slc‐001 slc‐001 NOUN njb-56 108 54     SPACE njb-56 108 55 positive positive ADJ njb-56 108 56     SPACE njb-56 108 57 514 514 NUM njb-56 108 58     SPACE njb-56 108 59 514 514 NUM njb-56 108 60     SPACE njb-56 108 61 negative negative ADJ njb-56 108 62     SPACE njb-56 108 63 slc‐002 slc‐002 NOUN njb-56 108 64     SPACE njb-56 108 65 positive positive ADJ njb-56 108 66     SPACE njb-56 108 67 514 514 NUM njb-56 108 68     SPACE njb-56 108 69 514 514 NUM njb-56 108 70     SPACE njb-56 108 71 negative negative ADJ njb-56 108 72     SPACE njb-56 108 73 slc‐003 slc‐003 PROPN njb-56 108 74     SPACE njb-56 108 75 positive positive ADJ njb-56 108 76     SPACE njb-56 108 77 514 514 NUM njb-56 108 78     SPACE njb-56 108 79 514 514 NUM njb-56 108 80     SPACE njb-56 108 81 negative negative ADJ njb-56 108 82     SPACE njb-56 108 83 slc‐004 slc‐004 NOUN njb-56 108 84     SPACE njb-56 108 85 positive positive ADJ njb-56 108 86     SPACE njb-56 108 87 514 514 NUM njb-56 108 88     SPACE njb-56 108 89 514 514 NUM njb-56 108 90     SPACE njb-56 108 91 negative negative ADJ njb-56 108 92     SPACE njb-56 108 93 slc‐005 slc‐005 ADJ njb-56 108 94     SPACE njb-56 108 95 positive positive ADJ njb-56 108 96     SPACE njb-56 108 97 514 514 NUM njb-56 108 98     SPACE njb-56 108 99 514 514 NUM njb-56 108 100     SPACE njb-56 108 101 negative negative ADJ njb-56 108 102     SPACE njb-56 108 103 slc‐006 slc‐006 NOUN njb-56 108 104     SPACE njb-56 108 105 positive positive ADJ njb-56 108 106     SPACE njb-56 108 107 514 514 NUM njb-56 108 108     SPACE njb-56 108 109 514 514 NUM njb-56 108 110     SPACE njb-56 108 111 negative negative PROPN njb-56 108 112     SPACE njb-56 108 113 slc‐007 slc‐007 PROPN njb-56 108 114     SPACE njb-56 108 115 positive positive ADJ njb-56 108 116     SPACE njb-56 108 117 514 514 NUM njb-56 108 118     SPACE njb-56 108 119 514 514 NUM njb-56 108 120     SPACE njb-56 108 121 negative negative ADJ njb-56 108 122     SPACE njb-56 108 123 slc‐008 slc‐008 PROPN njb-56 108 124     SPACE njb-56 108 125 positive positive ADJ njb-56 108 126     SPACE njb-56 108 127 514 514 NUM njb-56 108 128     SPACE njb-56 108 129 514 514 NUM njb-56 108 130     SPACE njb-56 108 131 negative negative ADJ njb-56 108 132     SPACE njb-56 108 133 slc‐009 slc‐009 NOUN njb-56 108 134     SPACE njb-56 108 135 positive positive ADJ njb-56 108 136     SPACE njb-56 108 137 514 514 NUM njb-56 108 138     SPACE njb-56 108 139 514 514 NUM njb-56 108 140     SPACE njb-56 108 141 negative negative ADJ njb-56 108 142     SPACE njb-56 108 143 slc‐010 slc‐010 NOUN njb-56 108 144     SPACE njb-56 108 145 positive positive ADJ njb-56 108 146     SPACE njb-56 108 147 514 514 NUM njb-56 108 148     SPACE njb-56 108 149 514 514 NUM njb-56 108 150     SPACE njb-56 108 151 negative negative PROPN njb-56 108 152     SPACE njb-56 108 153 slc‐011 slc‐011 PROPN njb-56 108 154     SPACE njb-56 108 155 positive positive ADJ njb-56 108 156     SPACE njb-56 108 157 514 514 NUM njb-56 108 158     SPACE njb-56 108 159 514 514 NUM njb-56 108 160     SPACE njb-56 108 161 negative negative ADJ njb-56 108 162     SPACE njb-56 108 163 slc‐012 slc‐012 PROPN njb-56 108 164     SPACE njb-56 108 165 positive positive ADJ njb-56 108 166     SPACE njb-56 108 167 514 514 NUM njb-56 108 168     SPACE njb-56 108 169 514 514 NUM njb-56 108 170     SPACE njb-56 108 171 negative negative PROPN njb-56 108 172     SPACE njb-56 108 173 slc‐013 slc‐013 PROPN njb-56 108 174     SPACE njb-56 108 175 positive positive ADJ njb-56 108 176     SPACE njb-56 108 177 514 514 NUM njb-56 108 178     SPACE njb-56 108 179 514 514 NUM njb-56 108 180     SPACE njb-56 108 181 negative negative ADJ njb-56 108 182     SPACE njb-56 108 183 slc‐014 slc‐014 NOUN njb-56 108 184     SPACE njb-56 108 185 positive positive ADJ njb-56 108 186     SPACE njb-56 108 187 514 514 NUM njb-56 108 188     SPACE njb-56 108 189 514 514 NUM njb-56 108 190     SPACE njb-56 108 191 negative negative ADJ njb-56 108 192     SPACE njb-56 108 193 slc‐015 slc‐015 PROPN njb-56 108 194     SPACE njb-56 108 195 positive positive ADJ njb-56 108 196     SPACE njb-56 108 197 514 514 NUM njb-56 108 198     SPACE njb-56 108 199 514 514 NUM njb-56 108 200     SPACE njb-56 108 201 negative negative ADJ njb-56 108 202     SPACE njb-56 108 203 slc‐016 slc‐016 PROPN njb-56 108 204     SPACE njb-56 108 205 positive positive ADJ njb-56 108 206     SPACE njb-56 108 207 514 514 NUM njb-56 108 208     SPACE njb-56 108 209 514 514 NUM njb-56 108 210     SPACE njb-56 108 211 negative negative ADJ njb-56 108 212     SPACE njb-56 108 213 slc‐017 slc‐017 PROPN njb-56 108 214     SPACE njb-56 108 215 positive positive ADJ njb-56 108 216     SPACE njb-56 108 217 514 514 NUM njb-56 108 218     SPACE njb-56 108 219 514 514 NUM njb-56 108 220     SPACE njb-56 108 221 negative negative ADJ njb-56 108 222     SPACE njb-56 108 223 slc‐018 slc‐018 NOUN njb-56 108 224     SPACE njb-56 108 225 positive positive ADJ njb-56 108 226     SPACE njb-56 108 227 514 514 NUM njb-56 108 228     SPACE njb-56 108 229 514 514 NUM njb-56 108 230     SPACE njb-56 108 231 negative negative ADJ njb-56 108 232     SPACE njb-56 108 233 slc‐019 slc‐019 NOUN njb-56 108 234     SPACE njb-56 108 235 positive positive ADJ njb-56 108 236     SPACE njb-56 108 237 514 514 NUM njb-56 108 238     SPACE njb-56 108 239 514 514 NUM njb-56 108 240     SPACE njb-56 108 241 negative negative ADJ njb-56 108 242     SPACE njb-56 108 243 slc‐020 slc‐020 ADJ njb-56 108 244     SPACE njb-56 108 245 positive positive ADJ njb-56 108 246     SPACE njb-56 108 247 514 514 NUM njb-56 108 248     SPACE njb-56 108 249 514 514 NUM njb-56 108 250     SPACE njb-56 108 251 negative negative ADJ njb-56 108 252     SPACE njb-56 108 253 slc‐021 slc‐021 NOUN njb-56 108 254     SPACE njb-56 108 255 positive positive ADJ njb-56 108 256     SPACE njb-56 108 257 514 514 NUM njb-56 108 258     SPACE njb-56 108 259 514 514 NUM njb-56 108 260     SPACE njb-56 108 261 negative negative ADJ njb-56 108 262     SPACE njb-56 108 263 slc‐022 slc‐022 NOUN njb-56 108 264     SPACE njb-56 108 265 positive positive ADJ njb-56 108 266     SPACE njb-56 108 267 514 514 NUM njb-56 108 268     SPACE njb-56 108 269 514 514 NUM njb-56 108 270     SPACE njb-56 108 271 negative negative ADJ njb-56 108 272     SPACE njb-56 108 273 slc‐023 slc‐023 PROPN njb-56 108 274     SPACE njb-56 108 275 positive positive ADJ njb-56 108 276     SPACE njb-56 108 277 514 514 NUM njb-56 108 278     SPACE njb-56 108 279 514 514 NUM njb-56 108 280     SPACE njb-56 108 281 negative negative ADJ njb-56 108 282     SPACE njb-56 108 283 slc‐024 slc‐024 NOUN njb-56 108 284     SPACE njb-56 108 285 positive positive ADJ njb-56 108 286     SPACE njb-56 108 287 514 514 NUM njb-56 108 288     SPACE njb-56 108 289 514 514 NUM njb-56 108 290     SPACE njb-56 108 291 negative negative ADJ njb-56 108 292     SPACE njb-56 108 293 table table NOUN njb-56 108 294     SPACE njb-56 108 295 3 3 NUM njb-56 108 296 . . PUNCT njb-56 108 297     SPACE njb-56 108 298 relationship relationship NOUN njb-56 108 299     SPACE njb-56 108 300 mdr‐tb mdr‐tb ADJ njb-56 108 301     SPACE njb-56 108 302 and and CCONJ njb-56 108 303     SPACE njb-56 108 304 g g X njb-56 108 305 / / SYM njb-56 108 306 c c NOUN njb-56 108 307     SPACE njb-56 108 308 polymorphism polymorphism NOUN njb-56 108 309     SPACE njb-56 108 310 in in ADP njb-56 108 311     SPACE njb-56 108 312 int4 int4 PROPN njb-56 108 313     SPACE njb-56 108 314 region region NOUN njb-56 108 315     SPACE njb-56 108 316 of of ADP njb-56 108 317     SPACE njb-56 108 318 slc11a1 slc11a1 NOUN njb-56 108 319     SPACE njb-56 108 320 to to ADP njb-56 108 321     SPACE njb-56 108 322 our our PRON njb-56 108 323     SPACE njb-56 108 324 study study NOUN njb-56 108 325     SPACE njb-56 108 326 as as ADV njb-56 108 327     SPACE njb-56 108 328 no no DET njb-56 108 329     SPACE njb-56 108 330 base‐line base‐line ADJ njb-56 108 331     SPACE njb-56 108 332 study study NOUN njb-56 108 333     SPACE njb-56 108 334 on on ADP njb-56 108 335     SPACE njb-56 108 336 mtb mtb NOUN njb-56 108 337     SPACE njb-56 108 338 strain strain NOUN njb-56 108 339     SPACE njb-56 108 340 genotyping genotyping NOUN njb-56 108 341     SPACE njb-56 108 342 has have AUX njb-56 108 343     SPACE njb-56 108 344 been be AUX njb-56 108 345     SPACE njb-56 108 346 conducted conduct VERB njb-56 108 347     SPACE njb-56 108 348 for for ADP njb-56 108 349     SPACE njb-56 108 350 nepalese nepalese ADJ njb-56 108 351     SPACE njb-56 108 352 mtb mtb NOUN njb-56 108 353     SPACE njb-56 108 354 isolates isolate NOUN njb-56 108 355     SPACE njb-56 108 356 till till SCONJ njb-56 108 357     SPACE njb-56 108 358 date date NOUN njb-56 108 359 . . PUNCT njb-56 108 360     SPACE njb-56 109 1 conclusion conclusion NOUN njb-56 109 2     SPACE njb-56 109 3 the the DET njb-56 109 4     SPACE njb-56 109 5 findings finding NOUN njb-56 109 6     SPACE njb-56 109 7 in in ADP njb-56 109 8     SPACE njb-56 109 9 this this DET njb-56 109 10     SPACE njb-56 109 11 study study NOUN njb-56 109 12     SPACE njb-56 109 13 suggests suggest VERB njb-56 109 14     SPACE njb-56 109 15 that that PRON njb-56 109 16     SPACE njb-56 109 17 still still ADV njb-56 109 18     SPACE njb-56 109 19 more more ADJ njb-56 109 20     SPACE njb-56 109 21 people people NOUN njb-56 109 22     SPACE njb-56 109 23 could could AUX njb-56 109 24     SPACE njb-56 109 25 be be AUX njb-56 109 26     SPACE njb-56 109 27 properly properly ADV njb-56 109 28     SPACE njb-56 109 29 diagnosed diagnose VERB njb-56 109 30     SPACE njb-56 109 31 for for ADP njb-56 109 32     SPACE njb-56 109 33 the the DET njb-56 109 34     SPACE njb-56 109 35 actual actual ADJ njb-56 109 36     SPACE njb-56 109 37 drug drug NOUN njb-56 109 38     SPACE njb-56 109 39 resistance resistance NOUN njb-56 109 40     SPACE njb-56 109 41 mutations mutation NOUN njb-56 109 42     SPACE njb-56 109 43 utilizing utilize VERB njb-56 109 44     SPACE njb-56 109 45 molecular molecular ADJ njb-56 109 46     SPACE njb-56 109 47 genomic genomic ADJ njb-56 109 48     SPACE njb-56 109 49 diagnostic diagnostic ADJ njb-56 109 50     SPACE njb-56 109 51 tools tool NOUN njb-56 109 52 . . PUNCT njb-56 109 53     SPACE njb-56 109 54 further far ADV njb-56 109 55     SPACE njb-56 109 56 study study VERB njb-56 109 57     SPACE njb-56 109 58 with with ADP njb-56 109 59     SPACE njb-56 109 60 a a DET njb-56 109 61     SPACE njb-56 109 62 greater great ADJ njb-56 109 63     SPACE njb-56 109 64 number number NOUN njb-56 109 65     SPACE njb-56 109 66 of of ADP njb-56 109 67     SPACE njb-56 109 68 mdr‐tb mdr‐tb ADJ njb-56 109 69     SPACE njb-56 109 70 patients patient NOUN njb-56 109 71     SPACE njb-56 109 72 is be AUX njb-56 109 73     SPACE njb-56 109 74 needed need VERB njb-56 109 75     SPACE njb-56 109 76 to to PART njb-56 109 77     SPACE njb-56 109 78 get get VERB njb-56 109 79     SPACE njb-56 109 80 the the DET njb-56 109 81     SPACE njb-56 109 82 actual actual ADJ njb-56 109 83     SPACE njb-56 109 84 scenario scenario NOUN njb-56 109 85     SPACE njb-56 109 86 of of ADP njb-56 109 87     SPACE njb-56 109 88 tb tb PROPN njb-56 109 89     SPACE njb-56 109 90 population population NOUN njb-56 109 91     SPACE njb-56 109 92 of of ADP njb-56 109 93     SPACE njb-56 109 94 nepal nepal ADJ njb-56 109 95 . . PUNCT njb-56 109 96       SPACE njb-56 109 97 reference reference NOUN njb-56 109 98     SPACE njb-56 109 99 world world NOUN njb-56 109 100     SPACE njb-56 109 101 health health NOUN njb-56 109 102     SPACE njb-56 109 103 organization organization NOUN njb-56 109 104 . . PUNCT njb-56 109 105     SPACE njb-56 110 1 global global ADJ njb-56 110 2     SPACE njb-56 110 3 tuberculosis tuberculosis NOUN njb-56 110 4     SPACE njb-56 110 5 control control NOUN njb-56 110 6 . . PUNCT njb-56 110 7     SPACE njb-56 111 1 a a DET njb-56 111 2     SPACE njb-56 111 3 short short ADJ njb-56 111 4     SPACE njb-56 111 5 update update NOUN njb-56 111 6     SPACE njb-56 111 7 to to ADP njb-56 111 8     SPACE njb-56 111 9 the the DET njb-56 111 10     SPACE njb-56 111 11 2009 2009 NUM njb-56 111 12     SPACE njb-56 111 13 report report NOUN njb-56 111 14 . . PUNCT njb-56 111 15     SPACE njb-56 112 1 2009 2009 NUM njb-56 112 2         SPACE njb-56 112 3 world world NOUN njb-56 112 4     SPACE njb-56 112 5 health health NOUN njb-56 112 6     SPACE njb-56 112 7 organization organization NOUN njb-56 112 8 . . PUNCT njb-56 112 9     SPACE njb-56 113 1 multidrug multidrug NOUN njb-56 113 2     SPACE njb-56 113 3 and and CCONJ njb-56 113 4     SPACE njb-56 113 5 extensively extensively ADV njb-56 113 6     SPACE njb-56 113 7 drug‐resistant drug‐resistant NOUN njb-56 113 8     SPACE njb-56 113 9 tb tb PROPN njb-56 113 10     SPACE njb-56 113 11 ( ( PUNCT njb-56 113 12 m m NOUN njb-56 113 13 / / SYM njb-56 113 14 xdr‐tb xdr‐tb PROPN njb-56 113 15 ) ) PUNCT njb-56 113 16     SPACE njb-56 113 17 2010 2010 NUM njb-56 113 18     SPACE njb-56 113 19 global global ADJ njb-56 113 20     SPACE njb-56 113 21 report report NOUN njb-56 113 22     SPACE njb-56 113 23 on on ADP njb-56 113 24     SPACE njb-56 113 25 surveillance surveillance NOUN njb-56 113 26     SPACE njb-56 113 27 and and CCONJ njb-56 113 28     SPACE njb-56 113 29 response response NOUN njb-56 113 30 . . PUNCT njb-56 113 31     SPACE njb-56 114 1 2010 2010 NUM njb-56 114 2         SPACE njb-56 114 3 national national ADJ njb-56 114 4     SPACE njb-56 114 5 tuberculosis tuberculosis NOUN njb-56 114 6     SPACE njb-56 114 7 center center NOUN njb-56 114 8 . . PUNCT njb-56 114 9     SPACE njb-56 115 1 national national ADJ njb-56 115 2     SPACE njb-56 115 3 tuberculosis tuberculosis NOUN njb-56 115 4     SPACE njb-56 115 5 control control NOUN njb-56 115 6     SPACE njb-56 115 7 programme programme NOUN njb-56 115 8     SPACE njb-56 115 9 nepal nepal NOUN njb-56 115 10     SPACE njb-56 115 11 ‐ ‐ AUX njb-56 115 12     SPACE njb-56 115 13 annual annual ADJ njb-56 115 14     SPACE njb-56 115 15 report report NOUN njb-56 115 16     SPACE njb-56 115 17 fy fy NOUN njb-56 115 18     SPACE njb-56 115 19 2065/66 2065/66 PROPN njb-56 115 20     SPACE njb-56 115 21 ( ( PUNCT njb-56 115 22 2008/2009 2008/2009 NUM njb-56 115 23 ) ) PUNCT njb-56 115 24 . . PUNCT njb-56 115 25     SPACE njb-56 116 1 2009 2009 NUM njb-56 116 2     SPACE njb-56 116 3 musser musser PROPN njb-56 116 4     SPACE njb-56 116 5 jm jm PROPN njb-56 116 6 . . PUNCT njb-56 116 7     SPACE njb-56 117 1 antimicrobial antimicrobial ADJ njb-56 117 2     SPACE njb-56 117 3 agent agent NOUN njb-56 117 4     SPACE njb-56 117 5 resistance resistance NOUN njb-56 117 6     SPACE njb-56 117 7 in in ADP njb-56 117 8     SPACE njb-56 117 9 mycobacteria mycobacterium NOUN njb-56 117 10 : : PUNCT njb-56 117 11     SPACE njb-56 117 12 molecular molecular ADJ njb-56 117 13     SPACE njb-56 117 14 genetic genetic ADJ njb-56 117 15     SPACE njb-56 117 16 insights insight NOUN njb-56 117 17 . . PUNCT njb-56 117 18     SPACE njb-56 118 1 clin clin PROPN njb-56 118 2     SPACE njb-56 118 3 microbiol microbiol PROPN njb-56 118 4     SPACE njb-56 118 5 rev rev PROPN njb-56 118 6 . . PROPN njb-56 118 7     SPACE njb-56 118 8 1995 1995 NUM njb-56 118 9     SPACE njb-56 118 10 oct;8(4):496‐514 oct;8(4):496‐514 NOUN njb-56 118 11 . . PUNCT njb-56 118 12     SPACE njb-56 118 13 nepal nepal ADJ njb-56 118 14     SPACE njb-56 118 15 journal journal NOUN njb-56 118 16     SPACE njb-56 118 17 of of ADP njb-56 118 18     SPACE njb-56 118 19 biotechnology biotechnology NOUN njb-56 118 20 . . PUNCT njb-56 118 21     SPACE njb-56 119 1 jan jan PROPN njb-56 119 2 . . PROPN njb-56 119 3     SPACE njb-56 119 4 2011 2011 NUM njb-56 119 5 , , PUNCT njb-56 119 6     SPACE njb-56 119 7 vol vol NOUN njb-56 119 8 . . PUNCT njb-56 119 9     SPACE njb-56 119 10 1 1 NUM njb-56 119 11 , , PUNCT njb-56 119 12     SPACE njb-56 119 13 no no INTJ njb-56 119 14 . . PUNCT njb-56 119 15     SPACE njb-56 120 1 1 1 X njb-56 120 2     SPACE njb-56 120 3 : : PUNCT njb-56 120 4     SPACE njb-56 120 5 14‐21 14‐21 NUM njb-56 120 6     SPACE njb-56 120 7 21 21 NUM njb-56 120 8       SPACE njb-56 120 9 biotechnology biotechnology NOUN njb-56 120 10     SPACE njb-56 120 11 society society NOUN njb-56 120 12     SPACE njb-56 120 13 of of ADP njb-56 120 14     SPACE njb-56 120 15 nepal nepal NOUN njb-56 120 16     SPACE njb-56 120 17 ( ( PUNCT njb-56 120 18 bsn bsn PROPN njb-56 120 19 ) ) PUNCT njb-56 120 20 , , PUNCT njb-56 120 21     SPACE njb-56 120 22 all all DET njb-56 120 23     SPACE njb-56 120 24 rights right NOUN njb-56 120 25     SPACE njb-56 120 26 reserved reserve VERB njb-56 120 27       SPACE njb-56 120 28 rattan rattan PROPN njb-56 120 29     SPACE njb-56 120 30 a a DET njb-56 120 31 , , PUNCT njb-56 120 32     SPACE njb-56 120 33 kalia kalia NOUN njb-56 120 34     SPACE njb-56 120 35 a a DET njb-56 120 36 , , PUNCT njb-56 120 37     SPACE njb-56 120 38 ahmad ahmad PROPN njb-56 120 39     SPACE njb-56 120 40 n. n. PROPN njb-56 120 41     SPACE njb-56 120 42 multidrug‐resistant multidrug‐resistant PROPN njb-56 120 43     SPACE njb-56 120 44 mycobacterium mycobacterium NOUN njb-56 120 45     SPACE njb-56 120 46 tuberculosis tuberculosis NOUN njb-56 120 47 : : PUNCT njb-56 120 48     SPACE njb-56 120 49 molecular molecular ADJ njb-56 120 50     SPACE njb-56 120 51 perspectives perspective NOUN njb-56 120 52 . . PUNCT njb-56 120 53     SPACE njb-56 121 1 emerg emerg VERB njb-56 121 2     SPACE njb-56 121 3 infect infect PROPN njb-56 121 4     SPACE njb-56 121 5 dis dis PROPN njb-56 121 6 . . PUNCT njb-56 121 7     SPACE njb-56 121 8 1998 1998 NUM njb-56 121 9     SPACE njb-56 121 10 apr‐jun;4 apr‐jun;4 PUNCT njb-56 121 11 ( ( PUNCT njb-56 121 12 2):195‐209 2):195‐209 NUM njb-56 121 13 . . PUNCT njb-56 121 14     SPACE njb-56 122 1 mokrousov mokrousov PROPN njb-56 122 2     SPACE njb-56 122 3 i i PRON njb-56 122 4 , , PUNCT njb-56 122 5     SPACE njb-56 122 6 narvskaya narvskaya PROPN njb-56 122 7     SPACE njb-56 122 8 o o PROPN njb-56 122 9 , , PUNCT njb-56 122 10     SPACE njb-56 122 11 otten otten VERB njb-56 122 12     SPACE njb-56 122 13 t t PROPN njb-56 122 14 , , PUNCT njb-56 122 15     SPACE njb-56 122 16 limeschenko limeschenko PROPN njb-56 122 17     SPACE njb-56 122 18 e e PROPN njb-56 122 19 , , PUNCT njb-56 122 20     SPACE njb-56 122 21 steklova steklova PROPN njb-56 122 22     SPACE njb-56 122 23 l l NOUN njb-56 122 24 , , PUNCT njb-56 122 25     SPACE njb-56 122 26 vyshnevskiy vyshnevskiy NOUN njb-56 122 27     SPACE njb-56 122 28 b. b. PROPN njb-56 122 29     SPACE njb-56 122 30 high high ADJ njb-56 122 31     SPACE njb-56 122 32 prevalence prevalence NOUN njb-56 122 33     SPACE njb-56 122 34 of of ADP njb-56 122 35     SPACE njb-56 122 36 katg katg PROPN njb-56 122 37     SPACE njb-56 122 38 ser315thr ser315thr NOUN njb-56 122 39     SPACE njb-56 122 40 substitution substitution NOUN njb-56 122 41     SPACE njb-56 122 42 among among ADP njb-56 122 43     SPACE njb-56 122 44 isoniazid‐resistant isoniazid‐resistant NOUN njb-56 122 45     SPACE njb-56 122 46 mycobacterium mycobacterium PROPN njb-56 122 47     SPACE njb-56 122 48 tuberculosis tuberculosis NOUN njb-56 122 49     SPACE njb-56 122 50 clinical clinical ADJ njb-56 122 51     SPACE njb-56 122 52 isolates isolate NOUN njb-56 122 53     SPACE njb-56 122 54 from from ADP njb-56 122 55     SPACE njb-56 122 56 northwestern northwestern ADJ njb-56 122 57     SPACE njb-56 122 58 russia russia PROPN njb-56 122 59 , , PUNCT njb-56 122 60     SPACE njb-56 122 61 1996 1996 NUM njb-56 122 62     SPACE njb-56 122 63 to to ADP njb-56 122 64     SPACE njb-56 122 65 2001 2001 NUM njb-56 122 66 . . PUNCT njb-56 122 67     SPACE njb-56 123 1 antimicrob antimicrob PROPN njb-56 123 2     SPACE njb-56 123 3 agents agent NOUN njb-56 123 4     SPACE njb-56 123 5 chemother chemother PROPN njb-56 123 6 . . PUNCT njb-56 123 7     SPACE njb-56 124 1 2002 2002 NUM njb-56 124 2     SPACE njb-56 124 3 may;46(5):1417‐24 may;46(5):1417‐24 PROPN njb-56 124 4 . . PUNCT njb-56 124 5     SPACE njb-56 125 1 takahashi takahashi PROPN njb-56 125 2     SPACE njb-56 125 3 k k PROPN njb-56 125 4 , , PUNCT njb-56 125 5     SPACE njb-56 125 6 hasegawa hasegawa PROPN njb-56 125 7     SPACE njb-56 125 8 y y PROPN njb-56 125 9 , , PUNCT njb-56 125 10     SPACE njb-56 125 11 abe abe PROPN njb-56 125 12     SPACE njb-56 125 13 t t PROPN njb-56 125 14 , , PUNCT njb-56 125 15     SPACE njb-56 125 16 yamamoto yamamoto PROPN njb-56 125 17     SPACE njb-56 125 18 t t PROPN njb-56 125 19 , , PUNCT njb-56 125 20     SPACE njb-56 125 21 nakashima nakashima PROPN njb-56 125 22     SPACE njb-56 125 23 k k PROPN njb-56 125 24 , , PUNCT njb-56 125 25     SPACE njb-56 125 26 imaizumi imaizumi PROPN njb-56 125 27     SPACE njb-56 125 28 k k PROPN njb-56 125 29 , , PUNCT njb-56 125 30     SPACE njb-56 125 31 shimokata shimokata PROPN njb-56 125 32     SPACE njb-56 125 33 k. k. PROPN njb-56 125 34     SPACE njb-56 125 35 slc11a1 slc11a1 PROPN njb-56 125 36     SPACE njb-56 125 37 ( ( PUNCT njb-56 125 38 formerly formerly ADV njb-56 125 39     SPACE njb-56 125 40 nramp1 nramp1 NOUN njb-56 125 41 ) ) PUNCT njb-56 125 42     SPACE njb-56 125 43 polymorphisms polymorphism NOUN njb-56 125 44     SPACE njb-56 125 45 associated associate VERB njb-56 125 46     SPACE njb-56 125 47 with with ADP njb-56 125 48     SPACE njb-56 125 49 multidrug‐resistant multidrug‐resistant ADJ njb-56 125 50     SPACE njb-56 125 51 tuberculosis tuberculosis NOUN njb-56 125 52 . . PUNCT njb-56 125 53     SPACE njb-56 126 1 tuberculosis tuberculosis NOUN njb-56 126 2     SPACE njb-56 126 3 ( ( PUNCT njb-56 126 4 edinb edinb ADJ njb-56 126 5 ) ) PUNCT njb-56 126 6 . . PUNCT njb-56 126 7     SPACE njb-56 127 1 2008 2008 NUM njb-56 127 2     SPACE njb-56 127 3 jan;88(1):52‐7 jan;88(1):52‐7 PROPN njb-56 127 4 . . PUNCT njb-56 127 5     SPACE njb-56 128 1 marquet marquet PROPN njb-56 128 2     SPACE njb-56 128 3 s s PROPN njb-56 128 4 , , PUNCT njb-56 128 5     SPACE njb-56 128 6 lepage lepage NOUN njb-56 128 7     SPACE njb-56 128 8 p p PROPN njb-56 128 9 , , PUNCT njb-56 128 10     SPACE njb-56 128 11 hudson hudson NOUN njb-56 128 12     SPACE njb-56 128 13 tj tj PROPN njb-56 128 14 , , PUNCT njb-56 128 15     SPACE njb-56 128 16 musser musser PROPN njb-56 128 17     SPACE njb-56 128 18 jm jm PROPN njb-56 128 19 , , PUNCT njb-56 128 20     SPACE njb-56 128 21 schurr schurr NOUN njb-56 128 22     SPACE njb-56 128 23 e. e. PROPN njb-56 128 24     SPACE njb-56 128 25 complete complete ADJ njb-56 128 26     SPACE njb-56 128 27 nucleotide nucleotide NOUN njb-56 128 28     SPACE njb-56 128 29 sequence sequence NOUN njb-56 128 30     SPACE njb-56 128 31 and and CCONJ njb-56 128 32     SPACE njb-56 128 33 genomic genomic ADJ njb-56 128 34     SPACE njb-56 128 35 structure structure NOUN njb-56 128 36     SPACE njb-56 128 37 of of ADP njb-56 128 38     SPACE njb-56 128 39 the the DET njb-56 128 40     SPACE njb-56 128 41 human human ADJ njb-56 128 42     SPACE njb-56 128 43 nramp1 nramp1 NOUN njb-56 128 44     SPACE njb-56 128 45 gene gene NOUN njb-56 128 46     SPACE njb-56 128 47 region region NOUN njb-56 128 48     SPACE njb-56 128 49 on on ADP njb-56 128 50     SPACE njb-56 128 51 chromosome chromosome NOUN njb-56 128 52     SPACE njb-56 128 53 region region NOUN njb-56 128 54     SPACE njb-56 128 55 2q35 2q35 NUM njb-56 128 56 . . PUNCT njb-56 128 57     SPACE njb-56 129 1 mamm mamm PROPN njb-56 129 2     SPACE njb-56 129 3 genome genome PROPN njb-56 129 4     SPACE njb-56 129 5 2000 2000 NUM njb-56 129 6 , , PUNCT njb-56 129 7     SPACE njb-56 129 8 11:755‐762 11:755‐762 NUM njb-56 129 9 . . PUNCT njb-56 129 10     SPACE njb-56 130 1 goswami goswami PROPN njb-56 130 2     SPACE njb-56 130 3 t t PROPN njb-56 130 4 , , PUNCT njb-56 130 5     SPACE njb-56 130 6 bhattacharjee bhattacharjee NOUN njb-56 130 7     SPACE njb-56 130 8 a a DET njb-56 130 9 , , PUNCT njb-56 130 10     SPACE njb-56 130 11 babal babal PROPN njb-56 130 12     SPACE njb-56 130 13 p p PROPN njb-56 130 14 , , PUNCT njb-56 130 15     SPACE njb-56 130 16 searle searle PROPN njb-56 130 17     SPACE njb-56 130 18 s s PROPN njb-56 130 19 , , PUNCT njb-56 130 20     SPACE njb-56 130 21 moore moore NOUN njb-56 130 22     SPACE njb-56 130 23 e e PROPN njb-56 130 24 , , PUNCT njb-56 130 25     SPACE njb-56 130 26 li li PROPN njb-56 130 27     SPACE njb-56 130 28 m m PROPN njb-56 130 29 , , PUNCT njb-56 130 30     SPACE njb-56 130 31 blackwell blackwell NOUN njb-56 130 32     SPACE njb-56 130 33 jm jm PROPN njb-56 130 34 . . PUNCT njb-56 130 35     SPACE njb-56 131 1 natural‐resistanceassociated natural‐resistanceassociated PROPN njb-56 131 2     SPACE njb-56 131 3 macrophage macrophage NOUN njb-56 131 4     SPACE njb-56 131 5 protein protein NOUN njb-56 131 6     SPACE njb-56 131 7 1 1 NUM njb-56 131 8     SPACE njb-56 131 9 is be AUX njb-56 131 10     SPACE njb-56 131 11 an an DET njb-56 131 12     SPACE njb-56 131 13 h+/bivalent h+/bivalent NOUN njb-56 131 14     SPACE njb-56 131 15 cation cation NOUN njb-56 131 16     SPACE njb-56 131 17 antiporter antiporter NOUN njb-56 131 18 . . PUNCT njb-56 131 19     SPACE njb-56 131 20 biochem biochem NOUN njb-56 131 21     SPACE njb-56 131 22 j j NOUN njb-56 131 23     SPACE njb-56 131 24 2001 2001 NUM njb-56 131 25 ; ; PUNCT njb-56 131 26     SPACE njb-56 131 27 354 354 NUM njb-56 131 28 : : PUNCT njb-56 131 29     SPACE njb-56 131 30 511–519 511–519 NUM njb-56 131 31 . . PUNCT njb-56 131 32     SPACE njb-56 131 33 taype taype NOUN njb-56 131 34     SPACE njb-56 131 35 ca can AUX njb-56 131 36 , , PUNCT njb-56 131 37     SPACE njb-56 131 38 castro castro PROPN njb-56 131 39     SPACE njb-56 131 40 jc jc PROPN njb-56 131 41 , , PUNCT njb-56 131 42     SPACE njb-56 131 43 accinelli accinelli PROPN njb-56 131 44     SPACE njb-56 131 45 ra ra PROPN njb-56 131 46 , , PUNCT njb-56 131 47     SPACE njb-56 131 48 herrera‐velit herrera‐velit VERB njb-56 131 49     SPACE njb-56 131 50 p p PROPN njb-56 131 51 , , PUNCT njb-56 131 52     SPACE njb-56 131 53 shaw shaw PROPN njb-56 131 54     SPACE njb-56 131 55 ma ma PROPN njb-56 131 56 , , PUNCT njb-56 131 57     SPACE njb-56 131 58 espinoza espinoza PROPN njb-56 131 59     SPACE njb-56 131 60 jr jr PROPN njb-56 131 61 . . PROPN njb-56 131 62     SPACE njb-56 131 63 association association NOUN njb-56 131 64     SPACE njb-56 131 65 between between ADP njb-56 131 66     SPACE njb-56 131 67 slc11a1 slc11a1 NOUN njb-56 131 68     SPACE njb-56 131 69 polymorphisms polymorphism NOUN njb-56 131 70     SPACE njb-56 131 71 and and CCONJ njb-56 131 72     SPACE njb-56 131 73 susceptibility susceptibility NOUN njb-56 131 74     SPACE njb-56 131 75 to to PART njb-56 131 76     SPACE njb-56 131 77 different different ADJ njb-56 131 78     SPACE njb-56 131 79 clinical clinical ADJ njb-56 131 80     SPACE njb-56 131 81 forms form NOUN njb-56 131 82     SPACE njb-56 131 83 of of ADP njb-56 131 84     SPACE njb-56 131 85 tuberculosis tuberculosis NOUN njb-56 131 86     SPACE njb-56 131 87 in in ADP njb-56 131 88     SPACE njb-56 131 89 the the DET njb-56 131 90     SPACE njb-56 131 91 peruvian peruvian ADJ njb-56 131 92     SPACE njb-56 131 93 population population NOUN njb-56 131 94 . . PUNCT njb-56 131 95     SPACE njb-56 132 1 infect infect VERB njb-56 132 2     SPACE njb-56 132 3 genet genet NOUN njb-56 132 4     SPACE njb-56 132 5 evol evol NOUN njb-56 132 6 . . PUNCT njb-56 132 7     SPACE njb-56 133 1 2006 2006 NUM njb-56 133 2     SPACE njb-56 133 3 sep;6(5):361‐7 sep;6(5):361‐7 PROPN njb-56 133 4 . . PUNCT njb-56 133 5     SPACE njb-56 134 1 pai pai NOUN njb-56 134 2     SPACE njb-56 134 3 m m VERB njb-56 134 4 , , PUNCT njb-56 134 5     SPACE njb-56 134 6 kalantri kalantri VERB njb-56 134 7     SPACE njb-56 134 8 s s PROPN njb-56 134 9 , , PUNCT njb-56 134 10     SPACE njb-56 134 11 dheda dheda PROPN njb-56 134 12     SPACE njb-56 134 13 k. k. PROPN njb-56 134 14     SPACE njb-56 134 15 new new ADJ njb-56 134 16     SPACE njb-56 134 17 tools tool NOUN njb-56 134 18     SPACE njb-56 134 19 and and CCONJ njb-56 134 20     SPACE njb-56 134 21 emerging emerge VERB njb-56 134 22     SPACE njb-56 134 23 technologies technology NOUN njb-56 134 24     SPACE njb-56 134 25 for for ADP njb-56 134 26     SPACE njb-56 134 27 the the DET njb-56 134 28     SPACE njb-56 134 29 diagnosis diagnosis NOUN njb-56 134 30     SPACE njb-56 134 31 of of ADP njb-56 134 32     SPACE njb-56 134 33 tuberculosis tuberculosis NOUN njb-56 134 34 : : PUNCT njb-56 134 35     SPACE njb-56 134 36 part part NOUN njb-56 134 37     SPACE njb-56 134 38 ii ii PROPN njb-56 134 39 . . PUNCT njb-56 134 40     SPACE njb-56 134 41 active active ADJ njb-56 134 42     SPACE njb-56 134 43 tuberculosis tuberculosis NOUN njb-56 134 44     SPACE njb-56 134 45 and and CCONJ njb-56 134 46     SPACE njb-56 134 47 drug drug NOUN njb-56 134 48     SPACE njb-56 134 49 resistance resistance NOUN njb-56 134 50 . . PUNCT njb-56 134 51     SPACE njb-56 135 1 expert expert NOUN njb-56 135 2     SPACE njb-56 135 3 rev rev PROPN njb-56 135 4     SPACE njb-56 135 5 mol mol PROPN njb-56 135 6     SPACE njb-56 135 7 diagn diagn NOUN njb-56 135 8 . . PUNCT njb-56 135 9     SPACE njb-56 136 1 2006 2006 NUM njb-56 136 2     SPACE njb-56 136 3 may;6(3):423‐32 may;6(3):423‐32 X njb-56 136 4 . . PUNCT njb-56 136 5     SPACE njb-56 137 1 basnet basnet PROPN njb-56 137 2     SPACE njb-56 137 3 r r PROPN njb-56 137 4 , , PUNCT njb-56 137 5     SPACE njb-56 137 6 hinderaker hinderaker PROPN njb-56 137 7     SPACE njb-56 137 8 sg sg PROPN njb-56 137 9 , , PUNCT njb-56 137 10     SPACE njb-56 137 11 enarson enarson PROPN njb-56 137 12     SPACE njb-56 137 13 d d PROPN njb-56 137 14 , , PUNCT njb-56 137 15     SPACE njb-56 137 16 malla malla PROPN njb-56 137 17     SPACE njb-56 137 18 p p PROPN njb-56 137 19 , , PUNCT njb-56 137 20     SPACE njb-56 137 21 mørkve mørkve PROPN njb-56 137 22     SPACE njb-56 137 23 o. o. PROPN njb-56 137 24     SPACE njb-56 137 25 delay delay NOUN njb-56 137 26     SPACE njb-56 137 27 in in ADP njb-56 137 28     SPACE njb-56 137 29 the the DET njb-56 137 30     SPACE njb-56 137 31 diagnosis diagnosis NOUN njb-56 137 32     SPACE njb-56 137 33 of of ADP njb-56 137 34     SPACE njb-56 137 35 tuberculosis tuberculosis NOUN njb-56 137 36     SPACE njb-56 137 37 in in ADP njb-56 137 38     SPACE njb-56 137 39 nepal nepal ADJ njb-56 137 40 . . PUNCT njb-56 137 41     SPACE njb-56 138 1 bmc bmc NOUN njb-56 138 2     SPACE njb-56 138 3 public public ADJ njb-56 138 4     SPACE njb-56 138 5 health health NOUN njb-56 138 6 . . PUNCT njb-56 138 7     SPACE njb-56 139 1 2009 2009 NUM njb-56 139 2     SPACE njb-56 139 3 jul jul PROPN njb-56 139 4     SPACE njb-56 139 5 14;9:236 14;9:236 NUM njb-56 139 6 . . PUNCT njb-56 139 7     SPACE njb-56 139 8 guo guo PROPN njb-56 139 9     SPACE njb-56 139 10 h h PROPN njb-56 139 11 , , PUNCT njb-56 139 12     SPACE njb-56 139 13 seet seet NOUN njb-56 139 14     SPACE njb-56 139 15 q q NOUN njb-56 139 16 , , PUNCT njb-56 139 17     SPACE njb-56 139 18 denkin denkin NOUN njb-56 139 19     SPACE njb-56 139 20 s s PROPN njb-56 139 21 , , PUNCT njb-56 139 22     SPACE njb-56 139 23 parsons parson NOUN njb-56 139 24     SPACE njb-56 139 25 l l NOUN njb-56 139 26 , , PUNCT njb-56 139 27     SPACE njb-56 139 28 zhang zhang PROPN njb-56 139 29     SPACE njb-56 139 30 y. y. PROPN njb-56 139 31     SPACE njb-56 139 32 molecular molecular ADJ njb-56 139 33     SPACE njb-56 139 34 characterization characterization NOUN njb-56 139 35     SPACE njb-56 139 36 of of ADP njb-56 139 37     SPACE njb-56 139 38 isoniazid‐resistant isoniazid‐resistant NOUN njb-56 139 39     SPACE njb-56 139 40 clinical clinical ADJ njb-56 139 41     SPACE njb-56 139 42 isolates isolate NOUN njb-56 139 43     SPACE njb-56 139 44 of of ADP njb-56 139 45     SPACE njb-56 139 46 mycobacterium mycobacterium NOUN njb-56 139 47     SPACE njb-56 139 48 tuberculosis tuberculosis NOUN njb-56 139 49     SPACE njb-56 139 50 from from ADP njb-56 139 51     SPACE njb-56 139 52 the the DET njb-56 139 53     SPACE njb-56 139 54 usa usa PROPN njb-56 139 55 . . PUNCT njb-56 139 56     SPACE njb-56 140 1 j j PROPN njb-56 140 2     SPACE njb-56 140 3 med med ADJ njb-56 140 4     SPACE njb-56 140 5 microbiol microbiol ADJ njb-56 140 6 . . PUNCT njb-56 140 7     SPACE njb-56 141 1 2006 2006 NUM njb-56 141 2     SPACE njb-56 141 3 nov;55(pt nov;55(pt PROPN njb-56 141 4     SPACE njb-56 141 5 11):1527‐31 11):1527‐31 NUM njb-56 141 6 . . PUNCT njb-56 141 7     SPACE njb-56 142 1 zhang zhang PROPN njb-56 142 2     SPACE njb-56 142 3 w w PROPN njb-56 142 4 , , PUNCT njb-56 142 5     SPACE njb-56 142 6 shao shao NOUN njb-56 142 7     SPACE njb-56 142 8 l l NOUN njb-56 142 9 , , PUNCT njb-56 142 10     SPACE njb-56 142 11 weng weng NOUN njb-56 142 12     SPACE njb-56 142 13 x x PROPN njb-56 142 14 , , PUNCT njb-56 142 15     SPACE njb-56 142 16 hu hu PROPN njb-56 142 17     SPACE njb-56 142 18 z z PROPN njb-56 142 19 , , PUNCT njb-56 142 20     SPACE njb-56 142 21 jin jin NOUN njb-56 142 22     SPACE njb-56 142 23 a a PRON njb-56 142 24 , , PUNCT njb-56 142 25     SPACE njb-56 142 26 chen chen PROPN njb-56 142 27     SPACE njb-56 142 28 s s PROPN njb-56 142 29 , , PUNCT njb-56 142 30     SPACE njb-56 142 31 pang pang PROPN njb-56 142 32     SPACE njb-56 142 33 m m VERB njb-56 142 34 , , PUNCT njb-56 142 35     SPACE njb-56 142 36 chen chen PROPN njb-56 142 37     SPACE njb-56 142 38 zw zw PROPN njb-56 142 39 . . PUNCT njb-56 142 40     SPACE njb-56 142 41 variants variant NOUN njb-56 142 42     SPACE njb-56 142 43 of of ADP njb-56 142 44     SPACE njb-56 142 45 the the DET njb-56 142 46     SPACE njb-56 142 47 natural natural ADJ njb-56 142 48     SPACE njb-56 142 49 resistance‐ resistance‐ PROPN njb-56 142 50 associated associate VERB njb-56 142 51     SPACE njb-56 142 52 macrophage macrophage NOUN njb-56 142 53     SPACE njb-56 142 54 protein protein NOUN njb-56 142 55     SPACE njb-56 142 56 1 1 NUM njb-56 142 57     SPACE njb-56 142 58 gene gene NOUN njb-56 142 59     SPACE njb-56 142 60 ( ( PUNCT njb-56 142 61 nramp1 nramp1 NOUN njb-56 142 62 ) ) PUNCT njb-56 142 63     SPACE njb-56 142 64 are be AUX njb-56 142 65     SPACE njb-56 142 66 associated associate VERB njb-56 142 67     SPACE njb-56 142 68 with with ADP njb-56 142 69     SPACE njb-56 142 70 severe severe ADJ njb-56 142 71     SPACE njb-56 142 72 forms form NOUN njb-56 142 73     SPACE njb-56 142 74 of of ADP njb-56 142 75     SPACE njb-56 142 76 pulmonary pulmonary ADJ njb-56 142 77     SPACE njb-56 142 78 tuberculosis tuberculosis NOUN njb-56 142 79 . . PUNCT njb-56 142 80     SPACE njb-56 143 1 clin clin PROPN njb-56 143 2     SPACE njb-56 143 3 infect infect PROPN njb-56 143 4     SPACE njb-56 143 5 dis dis PROPN njb-56 143 6 . . PUNCT njb-56 143 7     SPACE njb-56 143 8 2005 2005 NUM njb-56 143 9     SPACE njb-56 143 10 may may AUX njb-56 143 11     SPACE njb-56 143 12 1;40(9):1232‐ 1;40(9):1232‐ NUM njb-56 143 13 6 6 NUM njb-56 143 14 . . PUNCT njb-56 143 15     SPACE njb-56 143 16 epub epub NOUN njb-56 143 17     SPACE njb-56 143 18 2005 2005 NUM njb-56 143 19     SPACE njb-56 143 20 mar mar PROPN njb-56 143 21     SPACE njb-56 143 22 23 23 NUM njb-56 143 23 . . PUNCT njb-56 143 24     SPACE