layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts co-morbidity factors associated with influenza in nigeria aishatu b. gubio*1, saka j. muhammad2, aisha mamman3, ado zakari4 and oladayo biya1 1nigeria field epidemiology and laboratory training program (nfeltp), federal capital territory, nigeria; 2department of epidemiology and community health university of ilorin, faculty of clinical science, college of medicine, ibadan, nigeria; 3ahmadu bello university zaria, zaria shika, nigeria; 4kaduna state ministry of health kaduna, kaduna, nigeria objective to analyze influenza surveillance data from 2009 to 2010 the northern, southern, and western zones in nigeria and determined co-morbidity factors associated with influenza in nigeria. introduction influenza is viral illness that affects mainly the nose, throat, bronchi and occasionally, the lungs. influenza viruses have been an under-appreciated contributor to morbidity and mortality in nigeria. they are a substantial contributor to respiratory disease burden in nigeria and other developing countries. nigeria started influenza sentinel surveillance in 2008 to inform disease control and prevention efforts. methods we conducted a cross sectional study on secondary data analysis of influenza surveillance data from january 2009 to december 2010 obtained from nigeria’s federal ministry of health. epidemiological data were obtained for suspected ili and sari cases defined in accordance with who regional office for africa’s guidelines. laboratory confirmation for presence of influenza viruses was done using real time pcr assays. standardized case investigation forms used for sample collection were analyzed using epi-info software to generate frequency and proportions. results of the 5,860 suspected influenza cases reported between 2007 and 2011 from all the influenza sites in nigeria, 1104 (18.8%) and 2,510 (42.8%) of the total cases were recorded in 2009 and 2010 respectively. a total of 296 (7.3%) were positive for flu a, while 147 (2.9%) for flu b. the northern zone recorded a total of 1908(ar: 2.6/100,000) suspected cases while the southern zone recorded 554(ar: 1.48/100,000) and the western zone reported 549(2/100,000) suspected cases. of the 443 that were positive 43 (1.5%) were health workers, 446 (8.0%) had co infection of chronic respiratory tract disease, 50(3.7%) had co infection with heart disease. exposure to poultry was 2797(98.2%). conclusions co-morbidity factors associated with influenza viruses are an important contribution to the burden of respiratory illnesses in nigeria predominantly affecting children less than 5years and adults 25years and above. additional years of data are needed to better understand the co-morbidity factors associated epidemiology of influenza viruses in nigeria. influenza and chronic obstructive pulmonary disease (copd) only 585 (10.9%) had chest indrawing, with majority of the influenza subtype pdm a/h1n1 cases 14 (9.3%) had chest indrawing. influenza and chronic chest disease less than 5% of the respondents with influenza cases had chronic shortness of breath keywords surveillance; influenza; nigeria; co-morbidity acknowledgments we would like to acknowledge and express our sincere gratitude to the personnel of the national influenza reference laboratory, and the sentinel surveillance sites for assisting us technically during this write up. we would also like to thank the federal ministry of health specifically epidemiology division for all the support to the sentinel surveillance site. references oshin o. enzyme immunoassay of antibodies to influenza a virus in nigerian children. trop geogr med. 1979;31:509-17 njoku-obi an oo. viral respiratory diseases in nigeria: a serological survey. ii complement fixing antibody levels of influenza a, b and c and para-influenza 1. j trop med hyg 1966;69:147-9 mccoy l et al. a multiple cause-of-death analysis of asthma mortality in the united states, 1990-2001.journal of asthma, 2005, 42:757–763. olaleye od, omilabu sa, olabode ao and fagbami ah. serological evidence for influenza virus activity in nigeria (1985-1987). virologie 1989;40:11-7 adams a et al. the influence of patient and doctor gender on diagnosing coronary heart disease.sociology of health and illness, 2008, 30:1– 18. *aishatu b. gubio e-mail: yabintu@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e110, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts monitoring the impact of heat waves with emergency service utilization data in los angeles county emily kajita*, patricia araki, monica luarca and bessie hwang los angeles county dept. of public health, los angeles, ca, usa objective to assess current indicators for situational awareness during heat waves derived from electronic emergency department (ed) and 911 emergency dispatch call (edc) center data. introduction los angeles county’s (lac) early event detection system captures over 60% of total ed visits, as well as 800 to 1,000 emergency dispatch calls from los angeles city fire (lacf) daily. both ed visits and edc calls are classified into syndrome categories, and then analyzed for aberrations in count and spatial distribution. during periods of high temperatures, a heat report is generated and sent to stakeholders upon request. we describe how syndromic surveillance serves as an important near real-time, population-based instrument for measuring the impact of heat waves on emergency service utilization in lac. methods daily electronic ed registration data, edc calls, and high temperatures from palmdale, california were queried from january 1, 2010 to august 26, 2012 and aggregated into centers for disease control (cdc) weeks. a custom “heat exposure” category was created by searching ed chief complaints for key terms such as “heat stroke,” “hyperthermia,” “overheat,” and relevant icd9 diagnosis codes. similarly, edc calls were classified if related to “heat exposure.” pearson correlation tests were used to determine correlation between total ed visits, heat-related ed visits, heat-related edc calls, and daily maximum temperatures. results thus far 2012 has exceeded counts cumulative to august 26th for the past two years in the number of heat-related ed visits, heat-related edc calls, and hot days (table 1). in particular, the number of 105 degree-and-up days this year has already doubled what was observed all year during 2010 and 2011. age groups were similarly distributed in total ed visits, heat-related ed visits and edc calls, with a 18 to 44 year old majority (37%, 37%, and 42% respectively), followed by 45 to 64 year olds (23%, 21%, 23%). total ed visits did not increase during summer months, and were therefore not found to be correlated to temperature (!=0.06, p=0.46) or heat-related edc calls (!=0.07, p=0.4). heat-related ed visits however, were positively correlated with both edc calls (!=0.85, p< 0.001) and temperatures (!=0.59, p<0.001). heat-related edc calls were also correlated with temperature (!=0.56, p<0.001). conclusions due to small numbers of heat-related visits relative to total ed visits, any effects that increased temperatures may have on total ed visits are undetectable. total ed volume should therefore not be used as an indicator for measuring the impact of heat on lac’s population. filtering chief complaints to obtain heat-specific ed visits, however, enables patterns of increase to emerge which correlate with higher temperatures and heat-related emergency dispatch calls. about 35% of the week to week variation in heat-related ed visits, and 32% of the week to week variation in heat-related edc calls can be explained by week to week variations in temperature. that heat-related visits were similarly distributed in age as all visitors suggests that heat does not disproportionately affect children and the elderly any more than the other acute health conditions that bring visitors to the ed. syndromic analysis of ed data and edc can provide baselines for health conditions such as hyperthermia that are otherwise difficult to obtain. table 1. number of heat-related ed visits, edc calls, and days exceeding temperatures to 8/26 and to the year’s end. figure 1. weekly heat-related ed visits and heat-related edc calls (left axis); and 7-day averaged maximum daily temperatures in palmdale, california (right axis). heat-related ed visits are stratified by age group. keywords emergency department; dispatch; heat; situational awareness references weather underground. 2012. 27 aug. 2012. the weather channel companies. *emily kajita e-mail: ekajita@ph.lacounty.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e153, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts defining public health situation awareness – outcomes and metrics for evaluation don olson*, rob mathes, marc paladini and kevin konty nyc dohmh, long island city, ny, usa objective review concept of situation awareness (sa) as it relates to public health surveillance, epidemiology and preparedness [1]. outline hierarchical levels and organizational criteria for sa [2]. initiate consensus building process aimed at developing a working definition and measurable outcomes and metrics for sa as they relate to syndromic surveillance practice and evaluation. introduction a decade ago, the primary objective of syndromic surveillance was bioterrorism and outbreak early event detection (eed) [3]. syndromic systems for eed focused on rapid, automated data collection, processing and statistical anomaly detection of indicators of potential bioterrorism or outbreak events. the paradigm presented a clear and testable surveillance objective: the early detection of outbreaks or events of public health concern. limited success in practice and limited rigorous evaluation, however, led to the conclusion that syndromic surveillance could not reliably or accurately achieve eed objectives. at the federal level, the primary rationale for syndromic surveillance shifted away from bioterrorism eed, and towards allhazards biosurveillance and sa [4-6]. the shift from eed to sa occurred without a clear evaluation of eed objectives, and without a clear definition of the scope or meaning of sa in practice. since public health sa has not been clearly defined in terms of operational surveillance objectives, statistical or epidemiological methods, or measurable outcomes and metrics, the use of syndromic surveillance to achieve sa cannot be evaluated. methods this session is intended to provide a forum to discuss sa in the context of public health disease surveillance practice. the roundtable will focus on defining sa in the context of public health syndromic and epidemiologic surveillance. while sa is often noted in federal level documents as a primary rationale for biosurveillance [1, 4-6], it is rarely defined or described in operational detail. one working definition presents sa as “real-time analysis and display of health data to monitor the location, magnitude, and spread of an outbreak”, yet it does not elaborate on the methods, systems or evaluation requirements for sa in public health or biosurveillance [3]. in terms of translating sa into public health surveillance practice [1], we will discuss and define the requirements of public health sa based on its development and practice in other areas [2]. the proposed theoretical framework and evaluation criteria adapted and applied to public health sa [2] follow: level 1: perceive relevant surveillance data and epidemiological information. level 2: integrate surveillance and non-surveillance data in conjunction with operator goals to provide understanding of the meaning of the information. level 3: through perceiving (level 1) and integrating and understanding (level 2) provide prediction of future events and system states to allow for timely and effective public health decision making. results sample questions for discussion: what is the relevance of syndromic surveillance and biosurveillance in the sa framework? where does it fit within the current public health surveillance environment? to achieve the roundtable discussion objectives, the participants will work towards a consensus definition of sa for public health, and will outline measureable outcomes and metrics for evaluation of syndromic surveillance for public health sa. keywords evaluation; biosurveillance; situational awareness; syndromic surveillance; local public health acknowledgments this work was carried out in conjunction with a grant from the alfred p. sloan foundation (#2010-12-14). we thank the members of the new york city department of health and mental hygiene syndromic surveillance unit. references 1. thacker sb, qualters jr, lee lm. public health surveillance in the united states: evolution and challenges. mmwr 2012;61:3-9. 2. endsley mr. towards a theory of situation awareness. human factors 1995;37:32-64. 3. fricker rd. some methodological issues in biosurveillance. stat med 2011;30:403-15. 4. 109th congress of the united states, amendment to the public service act. pandemic and all-hazards preparedness act (2006). pub l no. 109-417, 101 et seq. 5. homeland security presidential directive 21 (hspd-21), “public health and medical preparedness,” 18 oct 2007. 6. white house, national strategy for biosurveillance, july 2012. *don olson e-mail: drolson@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e196, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts selecting targeted symptoms/syndromes for syndromic surveillance in rural china li tan1, jie zhang1, liwei cheng1, weirong yan1, 2, vinod k. diwan2, lu long1 and shaofa nie*1 1tongji medical college, wuhan city, china; 2karolinska institutet, stockholm, sweden objective to select the potential targeted symptoms/syndromes as early warning indicators for epidemics or outbreaks detection in rural china. introduction patients’ chief complaints (ccs) as a common data source, has been widely used in syndromic surveillance due to its timeliness, accuracy and availability (1). for automated syndromic surveillance, ccs always classified into predefined syndromic categories to facilitate subsequent data aggregation and analysis. however, in rural china, most outpatient doctors recorded the information of patients (e.g. ccs) into clinic logs manually rather than computers. thus, more convenient surveillance method is needed in the syndromic surveillance project (issc). and the first and important thing is to select the targeted symptoms/syndromes. methods epidemiological analysis was conducted on data from case report system in jingmen city (one study site in issc) from 2004 to 2009. initial symptoms/syndromes were selected by literature reviews. and finally expert consultation meetings, workshops and field investigation were held to confirm the targeted symptoms/syndromes. results 10 kinds of infectious diseases, 6 categories of emergencies, and 4 bioterrorism events (i.e. plague, anthrax, botulism and hemorrhagic fever) were chose as specific diseases/events for monitoring (table 1). two surveillance schemes were developed by reviewing on 565 literatures about clinical conditions of specific diseases/events and 14 literatures about ccs based syndromic surveillance. the former one was to monitor symptoms (19 initial symptoms), and then aggregation or analysis on single or combined symptom(s); and the other one was to monitor syndromes (9 initial syndromes) directly (table 2). the consultation meeting and field investigation identified three issues which should be considered: 1) the abilities of doctors especially village doctors to understand the definitions of symptoms/syndromes; 2) the workload of data collection; 3) the sensitive and specific of each symptom/syndrome. finally, scheme 1 was used and 10 targeted symptoms were determined (table 2). conclusions we should take the simple, stability and feasibility of operation, and also the local conditions into account before establishing a surveillance system. symptoms were more suitable for monitoring compared to syndromes in resource-poor settings. further evaluated and validated would be conducted during implementation. our study might provide methods and evidences for other developing countries with limited conditions in using automated syndromic surveillance system, to construct similar early warning system. table 1. epidemiological analysis on cases and emergencies data * chronic infectious diseases (excluded). † selected specific diseases (top 5) or events (non-infectious excluded). table 2 list of symptoms/syndromes * the incidence of symptom was >= 20% of specific disease(s)/event(s). ** the number of times of syndromes monitored was >= 4 times. asthma (4 times) and diarrhea (5 times) were excluded due to study objectives. † final targeted symptoms. keywords syndromic surveillance; chief complaint; early warning acknowledgments this study was funded by [european union’s] [european atomic energy community’s] seventh framework programme ([fp7/2007-2013] [fp7/2007-2011]) under grant agreement no. [241900]. references 1.chapman ww, dowling jn, wagner mm. generating a reliable reference standard set for syndromic case classification. j am med inform assoc. 2005;12:618-29. *shaofa nie e-mail: sf_nie@mails.tjmu.edu.cn online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e140, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts the organizational structures and human resources allocation of infectious disease surveillance system in rural china biao xu*1, qi zhao1, huijian cheng2, tao tao1, yipin zhu1, miao yu1 and hui yuan2 1school of public health, fudan university, shanghai, china; 2jiangxi provincial center for disease control and prevention, nanchang, china objective to understand the structure and capacity of current infection disease surveillance system, and to provide baseline information for developing syndromic surveillance system in rural china. introduction to meet the long-term needs of public health and social development of china, it is in urgency to establish a comprehensive response system and crisis management mechanism for public health emergencies. syndromic surveillance system has great advantages in promoting early detection of epidemics and reducing the burden of disease outbreak confirmation (1). the effective method to set up the syndromic surveillance system is to modify existing case report system, improve the organizational structures and integrate new function with the traditional system. methods since august 2011, an integrated syndromic surveillance project (issc) has been implemented in china. before the launching of the project, a cross-sectional study was carried out in fengxin county and yongxiu county of jiangxi province during october 11 to 18, 2010. institution information were investigated in the county hospital, township hospital and county center for disease control and prevention (cdc) to understand the performance of existing case report system for notifiable infectious diseases with regard to its structure, capacity and data collection procedure. health care workers from each township hospital and village health station were questionnaire interviewed for information on qualification of human resources, basic healthcare delivery condition, hardware and software needs for issc. results an internet-based real-time (quasi real-time) case report system for notifiable infectious diseases, based on the three-tier public health service system, had been established in these two counties since 2004. the farthest end of net user in case report system was township hospital. blood routine test, urine routine test, b ultrasound and electrocardiogram were available in all township hospitals. there was no laboratory equipment in village health stations in these two counties. all the township hospitals in these two counties were equipped with land-line telephones and desktop computers. the internet covers all township hospitals in both counties. most clinical doctors in township hospital(th) and village health station(vhs) were male. the age of doctors ranged from 21 to 72 years old, with the average at 42 and median at 40 years. the village health workers were significantly older, less educated and served in health care longer than the township hospital doctors. in yongxiu county, 95.6% of the village health stations were equipped with computers, including private-owned computers, and 80.7% of them had access to the internet; while in fengxin county, 66.5% of the village health stations possessed computers, among which most were private property of village doctors, and only 44.2% of them had access to the internet. conclusions the current case report system, with full coverage and stable human resource, has established a solid basis for developing syndromic surveillance system in rural china. the syndromic surveillance system could play its role in early detection of infectious disease outbreaks in rural area where laboratory service for infectious disease diagnosis are not available. however, the lack of computerized patient registration in village and township health care facilities and incomplete internet coverage in rural area and relatively low quality of human resource in village level should be taken into consideration seriously before establishing the syndromic surveillance system in rural china. figure1 flowchart of case report system for notifiable infectious disease in different level of health facilities in fengxin and yongxiu county keywords syndromic surveillance; rural area; human resources; case report system acknowledgments this study was funded by [european union’s] [european atomic energy community’s] seventh framework programme ([fp7/2007-2013] [fp7/2007-2011]) under grant agreement no. [241900]. references 1. heffernan r, mostashari f, das d, et al.syndromic surveillance in public health practice, new york city. emerging infectious diseases2004;10(5):858864. *biao xu e-mail: bxu@shmu.edu.cn online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e87, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts statistical models for biosurveillance of multiple organisms doyo g. enki*1, angela noufaily1, c. p. farrington1, paul h. garthwaite1, nick andrews2, andré charlett2 and chris lane2 1mathematics and statistics, the open university, milton keynes, united kingdom; 2health protection agency, london, united kingdom objective to look at the diversity of the patterns displayed by a range of organisms, and to seek a simple family of models that adequately describes all organisms, rather than a well-fitting model for any particular organism. introduction there has been much research on statistical methods of prospective outbreak detection that are aimed at identifying unusual clusters of one syndrome or disease, and some work on multivariate surveillance methods (1). in england and wales, automated laboratory surveillance of infectious diseases has been undertaken since the early 1990’s. the statistical methodology of this automated system is described in (2). however, there has been little research on outbreak detection methods that are suited to large, multiple surveillance systems involving thousands of different organisms. methods we obtained twenty years’ data on weekly counts of all infectious disease organisms reported to the uk’s health protection agency. we summarized the mean frequencies, trends and seasonality of each organism using log-linear models. to identify a simple family of models which adequately represents all organisms, the poisson model, the quasi-poisson model and the negative binomial model were investigated (3,4). formal goodness-of-fit tests were not used as they can be unreliable with sparse data. adequacy of the models was empirically studied using the relationships between the mean, variance and skewness. for this purpose, each data series was first subdivided into 41 half-years and de-seasonalized. results trends and seasonality were summarized by plotting the distribution of estimated linear trend parameters for 2250 organisms, and modal seasonal period for 2254 organisms, including those organisms for which the seasonal effect is statistically significant. relationships between mean and variance were summarized as given in figure 1. similar plots were used to summarize the relationships between mean and skewness. conclusions statistical outbreak detection models must be able to cope with seasonality and trends. the data analyses suggest that the great majority of organisms can adequately – though far from perfectly – be represented by a statistical model in which the variance is proportional to the mean, such as the quasi-poisson or negative binomial models. figure 1. relationships between mean and variance. (top) histogram of the slopes of the best fit lines for 1001 organisms; the value 1 corresponds to the quasi-poisson model; (bottom) log of variance plotted against log of mean for one organism. the full line is the best fit to the points; the dashed line corresponds to the quasi-poisson model; the dotted line corresponds to the poisson model. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e107, 2013 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts keywords biosurveillance; public health surveillance; data analysis; infectious disease outbreaks; statistical model acknowledgments this research was supported by a project grant from the uk medical research council, and by a royal society wolfson research merit award. references 1. unkel s, farrington cp, garthwaite ph, robertson c, andrews n. statistical methods for the prospective detection of infectious disease outbreaks: a review. j. r. statist. soc. a 2012; 175:49-82. 2. farrington cp, andrews nj, beale ad, catchpole ma. a statistical algorithm for the early detection of outbreaks of infectious disease. j. r. statist. soc. a 1996; 159: 547-563. 3. mccullagh p, nelder ja. generalized linear models. 2nd ed. london: chapman & hall; 1989. 4. hastie tj, tibshirani rj. generalized additive models. london: chapman & hall; 1990. *doyo g. enki e-mail: d.gragn@open.ac.uk online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e107, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts modeling baseline shifts in multivariate disease outbreak detection jialan que* and fu-chiang tsui university of pittsburgh, pittsburgh, pa, usa objective outbreak detection algorithms monitoring only disease-relevant data streams may be prone to false alarms due to baseline shifts. in this paper, we propose a multinomial-generalized-dirichlet (mgd) model to adjust for baseline shifts. introduction population surges or large events may cause shift of data collected by biosurveillance systems [1]. for example, the cherry blossom festival brings hundreds of thousands of people to dc every year, which results in simultaneous elevations in multiple data streams (fig. 1). in this paper, we propose an mgd model to accommodate the needs of dealing with baseline shifts. methods existing multivariate algorithms only model disease-relevant data streams (e.g., anti-fever medication sales or patient visits with constitutional syndrome for detection of flu outbreak). on the contrary, we also incorporate a non-disease-relevant data stream as a control factor. we assume that the counts from all data streams follow a multinomial distribution. given this distribution, the expected value of the distribution parameter is not subject to change during a baseline shift; however, it has to change in order to model an outbreak. therefore, this distribution inherently adjusts for the baseline shifts. in addition, we use the generalized dirichlet (gd) distribution to model the parameter, since gd distribution is one of the conjugate prior of multinomial [2]. we call this model the multinomial-generalized-dirichlet (mgd) model. results we applied mgd model in our previous proposed rank-based spatial clustering (mrsc) algorithm [3]. we simulated both outbreak cases and baseline shift phenomena. the experiment includes two groups of data sets. the first includes the data sets only injected with outbreak cases, and the second includes the ones with both outbreak cases and baseline shifts. we apply mrsc algorithm and a reference method, the multivariate bayesian scan statistic (mbss) algorithm (which only analyzes the disease-relevant data streams) [4], to both data sets. fig. 2 shows the performance of outbreak detection: the roc curves and amoc curves of analyzing the data sets with baseline shifts (solid lines) and without (dashed lines). we can see from fig. 2 that the performance of mbss dropped much more significantly than mrsc when analyzing the data sets with baseline shifts. conclusions the mgd model can be a good supplement model used to detect disease outbreaks in order to achieve both better sensitivity and better specificity especially when baseline shifts are present in the data. fig. 1 eight data streams of nrdm categories collected by rods system (anti-diarrhea, anti-fever adult, chest rubs, cough/cold, baby/child electrolytes, nasal products, rash and thermometers) between apr. 3, 2011 and apr. 8, 2011 in washington dc. fig. 2 roc and amoc curves of mrsc (red) and mbss (blue). the solid lines represent the two algorithms applied on the data sets injected with both outbreak cases and baseline shift phenomena. the dashed lines represent the two algorithms applied on the data sets injected with outbreak cases only. keywords biosurveillance; disease outbreak detection; algorithm acknowledgments this research was funded by pa department of health syndromic surveillance grant and cdc center of excellence grant p01-hk000086. references [1] reis, by, kohane, is and mandl, kd, an epidemiological network model for disease outbreak detection, plos medicine, vol. 4, p. 210, 2007. [2] wong, tt, generalized dirichlet distribution in bayesian analysis, applied mathematics and computation 97, pp. 165-181, 1998. [3] que, j and tsui, fc, rank-based spatial clustering: an algorithm for rapid outbreak detection, j am med inform assoc, vol. 18, pp. 218224, 2011. [4] neill, db and cooper, gf, a multivariate bayesian scan statistic for early event detection and characterization, machine learning, vol. 29, pp. 261-282, 2010. *jialan que e-mail: jialan.que@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e9, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts utilization of various data sources to locate west nile clusters in tulsa county nicole schlaefli*2, kiran duggirala2 and scott meador1 1tulsa city-county health department, enviromental health program, tulsa, ok, usa; 2tulsa city-county health department, health, data, and evaluation divison, tulsa, ok, usa objective identify, analyze, and summarize wnv in tulsa county, oklahoma introduction as the summer temperatures soared to their highest ever recorded, oklahoma experienced its highest disease count ever since the disease had been discovered in new york in 1999. tulsa county is the second most populous county in oklahoma and accounted for over onefourth of the west nile cases in oklahoma. tulsa city county health department is also the only funded mosquito control program in the state that regularly reports to cdc’s abornet. methods as part of the mosquito surveillance program run by tcchd’s environmental health program, 75 mosquito traps are placed around the county. the traps are tested once a week during the season which runs may to november. the areas that the traps are located in are then sprayed with mosquito repellent. the ehp also gathers addresses of the west nile positive persons that are reported to the epidemiology department. the positive trap locations and the human case addresses are then mapped onto a geographic representation map of tulsa county using arcgis arcmap 10.0 software.historical trend analysis data of past west nile cases by year, age, location and climate are then compared to the current year. results from interviews conducted with west nile positive human cases, the majority of cases reported the likelihood of being bitten on their property. once the human case locations were overlaid with positive trap locations and a map of the storm drain system in tulsa county, clusters formed and areas that needed to be sprayed were identified. conclusions recommendations are made throughout the season to community officials based on analysis and results found. lessons learned from the outbreak response conducted included: addition of larvacidal treatment of tulsa county storm drainage system aggressive marketing campaign in regards to prevention methods purpose and role of long term acute care centers in regards to human recovery proposed creation of a west nile survivors group west nile virus disease keywords surveillance; west nile; mosquito acknowledgments christie mcdonald-hamm, mph; surveillance officer, department of informatics; oklahoma state department of health references tulsa county, oklahoma public works department public health investigation of disease database in oklahoma (phiddo) mosquito database, environmental health program, tulsa city county health department http://www.cdc.gov/ncdod/dvbid/westnile/index.htm centers for disease control and prevention, u.s. environmental protection agency, national oceanic and atmospheric agency, and american water works association. 2010. when every drop counts: protecting public health during drought conditions— a guide for public health professionals. atlanta: u.s. department of health and human services. *nicole schlaefli e-mail: nschlaefli@tulsa-health.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e143, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts public health surveillance in pilot drinking water contamination warning systems chrissy dangel*1, steven c. allgeier1, darcy gibbons2 and adam haas2 1us epa, cincinnati, oh, usa; 2csc science & engineering, alexandria, va, usa objective this paper describes the lessons learned from operation and maintenance of the public health surveillance (phs) component of five pilot city drinking water contamination warning systems (cws) including: cincinnati, new york, san francisco, philadelphia, and dallas. introduction the u.s. environmental protection agency (epa) designed a program to pilot multi-component contamination warning systems (cwss), known as the “water security initiative (wsi).” the cincinnati pilot has been fully operational since january 2008, and an additional four pilot utilities will have their own, custom cwss by the end of 2012. a workshop amongst the pilot cities was conducted in may 2012 to discuss lessons learned from the design, implementation, operation, maintenance, and evaluation of each city’s phs component. methods when evaluating potential surveillance tools to integrate into a drinking water contamination warning system, it is important to consider design decisions, dual use applications/considerations, and the unique capabilities of each tool. the pilot cities integrated unique surveillance tools, which included a combination of automated event detection tools and communication and coordination procedures into their respective phs components. the five pilots performed a thorough, technical evaluation of each component of their cws, including phs. results four key lessons learned were identified from implementation of the phs component in the five pilot cities. first, improved communication and coordination between public health and water utilities was emphasized as an essential goal even if it were not feasible to implement automated surveillance systems. the wsi pilot project has helped to strengthen this communication pathway through the process of collaborating to develop the component, and through the need to investigate phs alerts. second, the approximate location of specific cases associated with phs alerts was found to be an essential feature that allowed a crosscomparison to water pressure zones when attempting to locate the source of possible contamination. more specific location data (e.g., latitude and longitude) leads to a more efficient investigation, however, just narrowing the case location down to a specific hydraulic region within the water distribution system is extremely useful. third, the ability to quickly visualize spatial distribution of cases via a visual interface was reported to be valuable to investigators during alert investigations. most pilots implemented a cws dashboard, in the form of a central graphical display, which presents the alerts and was used by the water utility and public health to obtain an understanding of geospatial relationships between cases, alerts and water pressure zones. finally, public health and water utility representatives from several of the wsi pilots acknowledged that their automated surveillance tools currently have limited capabilities for detection of chemical contaminants (which may result in a sudden onset of symptoms), with the main deficiency being the timeliness of the alerts relative to the window of opportunity to respond in a meaningful and effective manner. while they currently focus on detection of traditional waterborne diseases, these tools could potentially be adapted to also detect chemical contaminants. conclusions the results of the pilots have demonstrated that it is important to construct and formalize standard operating procedures, so that public health personnel and water utilities have a standard communication protocol. as a basic step to a phs component, it is important to establish a relationship between utilities and public health. in addition to the efforts of the wsi pilots, research is currently being conducted by the u.s. epa to analyze health seeking behavior of symptomatic individuals, because all phs tools rely on data generated from behavior pursued by the affected population during a public health incident. results from analysis of both emergency department data and poison control center follow-up phone data are currently underway. keywords evaluation; public health surveillance; lessons learned; contamination warning system; drinking water references [1] us epa. 2008. water security initiative: cincinnati pilot post-implementation system status report. epa 817-r-08-004. *chrissy dangel e-mail: dangel.chrissy@epa.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e93, 2013 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts current assessment of risks of anthrax outbreaks in ukraine nataliya vydayko* and yuriy novohatniy state institution ukrainian center of diseases control and monitoring ministry of health of ukraine (si ucdcm moh), kyiv, ukraine introduction anthrax is an acute especially dangerous infectious disease of animals and humans. bacillus anthracis is a potential bioterrorism tool. in ukraine, there are favorable natural conditions for the spread of anthrax. there are 13.5 thousand of constantly anthrax-troubled points. anthrax epidemic situation in ukraine could be characterized as unstable. because of the continuing reform of ukrainian human health entities, the state sanitary epidemiological service (sses) has lost its control functions and is remaining in an uncertain state, which increases possible risks. methods epidemiological analysis of official data has been performed using information from the following sources: state sanitary epidemiological service of ukraine (sses), state veterinary and phytosanitary service of ukraine, and analytical materials from si ucdcm. collected papers distribution and epidemiological characteristics of major human infectious diseases in ukraine (kyiv research institute of epidemiology, microbiology and parasitology, 1976) were also used during the study. materials were compiled for the period from 1945 to 2015. results in the early xx century, more than 10,000 cases of anthrax in humans were annually registered in tsarist russia. in 1913, 1,473 cases of anthrax in animals were recorded only in kherson province (currently, kherson oblast of ukraine). the morbidity among humans increased again during the wwii. in the late 40s, massive epizootic anthrax among animals was eliminated and morbidity among people significantly reduced because of planned government measures, strengthened veterinary, sanitary, and epidemiological surveillance. since 1950, significant reduction of incidence of human anthrax has been being recorded in ukraine. since 1964, certification and mapping of persistent anthraxtroubled points in ukraine have been being performed. compulsory vaccination of people against anthrax was cancelled and compulsory vaccination of all livestock was introduced in 1990. the period from 1976 to 1993 is characterized as epidemically safe. single cases of the disease in human were registered with intensity rates of 0.01 – 0.002 per 100,000 population (excluding 1985). no human cases were registered during the certain years: 1978, 1982, 1987, 1988. the epidemic situation complicated during the period 19942001. the following outbreaks were registered: table 1. total number of disease cases/ including the number of cases during outbreaks within regions the main reason for the complication of the epidemiological situation was weakening of epidemiological and veterinary surveillance during the economic crisis characterizing this period. epizootiological outbreaks arose from incomplete anti-anthrax vaccination of agricultural animals and from violation of veterinarysanitary rules for their keeping as well. more than 80% of human infection cases happened resulting compelled cattle slaughtering, while the rest 20% resulted from meat product distribution and consumption without corresponding sanitary-veterinary expertise. six human cases of anthrax were registered during 2002-2015. fig. 1. dynamics of anthrax cases in humans in ukraine during 1945 – 2015 (absolute numbers) table 2. chronology of anthrax epidemiological surveillance milestones in ukraine conclusions relative wellbeing regarding anthrax in ukraine persists owing to the implementation of ruled veterinary-sanitary activities and state sanitary epidemiological surveillance in meatand leather-processing industries as well as because of active food control. the main risks, which could trigger complication in the current epidemiological situation with anthrax, are the following: 1) uncertainty in the system of sanitary-epidemiological and veterinary surveillance, which resulted from the reformation of the state sanitary-epidemiological and state veterinary services. 2) existence of favorable conditions for anthrax agent circulation (considerable number of persistent anthrax-troubled points in all regions). 3) economic instability in the country. 4) uncontrolled epidemic situation in the zone of the anti-terrorist operation (donetsk and luhansk oblasts). table 1. table 2. keywords anthrax; outbreaks; risk assessment; epidemiological surveillance *nataliya vydayko e-mail: vydaykon@ukr.net online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e151, 2017 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a piece of the public health surveillance puzzle: social contacts among school-aged children molly leecaster*1, warren pettey1, damon toth1, jeanette rainey2, amra uzicanin2 and matthew samore1 1internal medicine, university of utah, salt lake city, ut, usa; 2centers for disease control and prevention, atlanta, ga, usa objective to enhance public health surveillance and response for acute respiratory infectious diseases by understanding social contacts among school-aged children introduction timely and effective public health decision-making for control and prevention of acute respiratory infectious diseases relies on early disease detection, pathogen properties, and information on contact behavior affecting transmission. however, data on contact behavior are currently limited, and when available are commonly obtained from traditional self-reported contact surveys [1, 2]. information for contacts among school-aged children is especially limited, even though children frequently have higher attack rates than adults, and schoolrelated transmission is commonly predictive of subsequent community-wide outbreaks, especially for pandemic influenza. within this context, high-quality data are needed about social contacts. precise contact estimates can be used in mathematical models to understand infectious disease transmission [3] and better target surveillance efforts. here we report preliminary data from an ongoing 2year study to collect social contact data on school-aged children and examine the transmission dynamics of an influenza pandemic. methods our aim is to capture mixing patterns and contact rates of schoolaged children in 24 schools and other non-school-related venues. we used a stratified design to ensure coverage of urban, suburban, and rural school districts, as well as climatically different areas (mountains and desert) in utah. elementary, middle, and high schools were chosen in each stratum. we defined a self-reported contact as anyone with whom the participant talked to face-to-face, played with, or touched. contact logs collected subjective information (age, location, and duration) on self-reported contacts during a 2-day period. objective contact data were collected by using proximity sensors [4] that recorded signals from other sensors within approximately 3-4 feet. mixing patterns during school and non-school-related activities were summarized for participating school-aged children. we developed contact networks using proximity sensor data, providing visualizations of contact patterns as well as numeric contact measures. contact networks were characterized with respect to degree distribution, and density. the degree for each person was calculated as the number of unique contacts. the density for a network was calculated as the number of observed contacts divided by the number of possible contacts. results two elementary schools, four summer camps, and one club participated in the study between may and august, 2012. data were processed for the two schools and one camp. the mean degrees for the two schools were 28 and 29, with network sizes 109 and 129, respectively. the mean degree from camp was 43, whose network size was 141. the density of contacts was 0.26 and 0.22 for the schools and 0.31 for the camp. the density within classrooms at the two schools ranged from 0.78 to 0.98. school-aged children typically underreported contacts using the contact log compared with objective proximity sensor data; this difference was statistically significant. conclusions the variability in these and other contact network characteristics represent factors that could impact influenza transmission. quantifying these factors improves our understanding of influenza transmission dynamics, which in turn can be used to adapt surveillance methods and control and prevention strategies. almost all contact among students in our two elementary schools occurs within the classroom and the contact patterns differ by classroom, due to desk arrangement or other characteristics. thus, during an elementary school outbreak it may be beneficial to focus on classroom-specific surveillance and control strategies. the study is ongoing and we expect the variability in contact rates and mixing patterns will be even greater for middle and high schools where students switch classrooms and classmates each period. these schools could benefit from alternative surveillance and control strategies that account for the heightened overall mixing of the student body. keywords children; respiratory infectious disease; social network; transmission model; proximity sensor acknowledgments this study is funded by the centers for disease control and prevention 5u01ck000177. references 1. mossong, j, et al 2008 plos medicine 5(3): 381–391. 2. glass l and r glass 2008 bmc public health 8(61). 3. keeling m and k eames 2005 j.r.soc.interface 2:295-307. 4. salathé m, et al 2010 pnas 1009094108. *molly leecaster e-mail: molly.leecaster@hsc.utah.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e25, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts casefinder: a flexible real-time online surveillance registry for infectious disease physicians to report cases of carbapenem-resistant enterobacteriaceae (cre) donald curtis*1, scott weissman2, dimitri drekonja3, susan beekmann4, benjamin buckmaster1, john lynch5, april abbott6, ferric fang6 and philip polgreen4 1coe college, cedar rapids, ia, usa; 2seattle children’s hospital, seattle, wa, usa; 3minneapolis veterans affairs medical center, minneapolis, mn, usa; 4university of iowa, iowa city, ia, usa; 5harborview medical center, seattle, wa, usa; 6university of washington, seattle, wa, usa objective to create a flexible online surveillance system for infectious disease experts to report cases of emerging infectious diseases. introduction the infectious disease society of america’s emerging infections network (ein) is a sentinel network of over 1,200 practicing infectious disease physicians, supported by the centers for disease control and prevention (cdc). in january 2012, the ein listserv fielded a member inquiry about treatment recommendations for a complicated polymicrobial wound infection in a traveler returning to the united states from india. the posting led to a member-to-member communication that resulted in shipment of clinical microbiology isolates from one member’s hospital to another’s research laboratory. molecular evaluation of the clinical isolates uncovered previously undetected carriage of the emerging ndm-1 enzyme in 2 of the enterobacteriaceae species. based on this interaction, we built a flexible online surveillance registry (casefinder) for infectious disease physicians to report cases of cre. methods to ascertain the frequency and nature of cre infections treated by ein members, a survey was sent to ein members in july 2012 that elicited risk factors and clinical features associated with cre. survey opt-out items also allowed respondents to specify that they had not treated any cre infections. concurrently, we developed a formal relational data model for cre infection survey data, allowing for analysis and visualization. the data model was implemented in python using the object-relational mapping provided by the django web framework, which we used to implement the backend server component to the online registry. an interactive front-end web application, written in javascript using the jquery library, retrieves data via the ajax web protocol. geolocated data is visualized using the openlayers library to render map tiles and provide interactive controls such as panning and zooming. results the crowd-sourced online registry for infectious disease experts to report cre infections, called casefinder (http://casefinder.org/), was developed, released, and seeded with data from the ein survey. to date, a total of 69 cases have been submitted, describing 53 infections with klebsiella pneumoniae, 7 with escherichia coli and 9 with other enterobacteriaceae, representing 7 of 9 us census divisions. another 214 members have indicated that they have not seen any cases to date. casefinder includes: an online data entry component (to supplant the original ein listserv survey); real-time filtering of data; and interactive maps that geolocate survey responses using the first 2 digits of the treating facility’s zip code. users can filter data based on species, clinical features (age, gender), resistance profile, or 2-digit zip code. casefinder can also display clinical case data in an exportable line-item format. conclusions we have created a web-based data registry for cre infections in the us. populated by ein survey responses, the registry already has a collection 283 data points—69 cases of cre and 214 reports indicating the absence of cases—and is open for ongoing submission of data represented in real time. this system can serve as a de facto national surveillance system for cre infections an important but not yet universally reportable condition. our platform can be expanded to map and track other emerging infections seen by infectious diseases physicians. we are currently working to incorporate molecular fingerprinting and typing information into the data model. the site will also provide incentives for infectious disease experts to submit cases in underrepresented geographic areas. in future efforts we will incorporate “machine learning” techniques to leverage knowledge from infectious disease experts on existing cases and provide features such as an intelligent automated alert system. keywords surveillance; carbapenemases; antibiotic resistance; enterobacteriaceae; klebsiella pneumoniae *donald curtis e-mail: dcurtis@coe.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e28, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts traditional and mobile public health alert communications with health care providers debra revere*, ian painter and janet baseman university of washington, seattle, wa, usa objective to systematically compare mobile (sms) and traditional (email, fax) communication strategies to identify which modality is most effective for communication of health alerts and advisories between public health agencies and health care providers in order to improve emergency preparedness and response. introduction the effectiveness of emergency preparedness and response systems depends, in part, on the effectiveness of communication between agencies and individuals involved in emergency response, including health care providers who play a significant role in planning, event detection, response and communication with the public. although much attention has been paid to the importance of communicating clinical data from health care providers to public health agencies for purposes of early event detection and situational awareness (e.g., biosense) and to the need for alerting health care providers of public health events (e.g., health alert networks), no studies to date have systematically identified the most effective methods of communication between public health agencies and community health care providers for purposes of public health emergency preparedness and response. the reach (rapid emergency alert communication in health) study is a 4-year randomized controlled trial to evaluate and compare the effectiveness of mobile (sms) and traditional (email, fax) communication strategies for sending public health messages to health care providers—physicians, pharmacists, nurse practitioners, physician’s assistants and veterinarians. methods providers were recruited from three sites (king county, wa; spokane county, wa; and across the state of montana; n=845) and randomized to receive time-sensitive public health messages via email, fax, short message service (sms) or to a control group that did not receive messages. for one year, alerts based on real events of public health interest were sent quarterly with follow-up telephone interviews conducted 5-10 days after the delivery date. interviews consisted of approximately six questions that elicited information about message receipt, recall of its content and perceived credibility and trustworthiness of the message and source. in addition, provider access to online alert information and delivery success or failure was collected. results frequency of receipt, timeliness, content awareness, perceived credibility and perceived trustworthiness were measured and compared across communication delivery systems. on average 84.0% of participants were contacted in each follow-up survey following all alerts and across all three sites. primary data analysis was designed to measure differences between the three communication groups using intent-to-treat methods. a set of secondary analyses examined the outcomes excluding providers who could not have received messages (due to incorrect contact information, known technical failures, or because providers could not receive messages by the assigned delivery message—for example, a provider without a fax number randomized to the fax group). we will discuss preliminary results of intent-to-treat analyses regarding rate of recall of study alert message content between traditional and mobile communications and perceived trustworthiness and credibility of message and message source by providers. in addition, we will report on frequency of accessing online alert information between traditional and mobile delivery groups. conclusions there is currently no evidence-based research to guide or improve the practice of public health communication between public health agencies and health care providers before, during and after a public health emergency. improving this communication via the use of effective media can enhance disease surveillance, which will aid in early detection and enhance case finding and situational awareness for public health emergencies. by systematically evaluating the relative effectiveness of mobile and traditional message delivery systems for emergency preparedness and response communications, the reach study contributes to building the evidence base for novel and effective approaches to emergency communications. keywords emergency preparedness and response; public health communication; surveillance and alerting acknowledgments this work was made possible by the cdc office of public health preparedness and response extramural research program preparedness and emergency response research centers award, grant no. 5p01tp000297, to the university of washington. the contents are solely the responsibility of the authors and do not necessarily represent the official views of the cdc. *debra revere e-mail: drevere@uw.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e124, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts towards estimation of electronic laboratory reporting volumes in a meaningful use world brian e. dixon*1, 2, 4, roland e. gamache1, 2 and shaun j. grannis3, 2 1school of informatics, indiana university, indianapolis, in, usa; 2regenstrief institute, indianapolis, in, usa; 3indiana university school of medicine, indianapolis, in, usa; 4center of excellence on implementing evidence-based practice, department of veterans affairs, veterans health administration, health services research and development service, indianapolis, in, usa objective to support health department estimation of future electronic laboratory report volumes from hospitals that achieve stage 2 meaningful use. introduction the american recovery and reinvestment act of 2009 authorized the centers for medicare and medicaid services (cms) to incentivize hospitals and physicians to become meaningful users of electronic health record (ehr) systems. in a final rule issued august 2012, cms outlined the requirements for stage 2 meaningful use to be effective in 2014 (1). the stage 2 criteria require eligible hospitals to submit electronic laboratory reports to health departments. while many state health departments receive some portion of notifiable disease reports electronically, the final stage 2 rule is likely to increase the volume of incoming electronic reports. the centers for disease control and prevention are urging health departments to prepare for the sharp increase in electronic laboratory reporting (elr). crucial to preparedness is estimation of how many elr reports can be expected. however, few health departments have experience with high volume elr, making estimation difficult. the indiana network for patient care (inpc), a regional health information exchange, has been processing high volumes of elr for over a decade (2). to support health departments estimate potential elr increases, the inpc examined its current volumes from hospitals with advanced ehr capabilities. methods the inpc uses an automated case-detection system called the notifiable condition detector (ncd) developed by investigators at the regenstrief institute (3). the ncd uses a standards-based messaging and vocabulary infrastructure to process more than 350,000 clinical transactions daily, including laboratory studies, diagnoses, and transcriptions from more than 40 hospitals, national labs and local ancillary service organizations. data processed between january 1, 2010 and december 15, 2011 were extracted from the ncd. validated cases of notifiable conditions of interest to the indiana state department of health were filtered out for use in this analysis. we further eliminated duplicate cases of the same reportable record for the same individual. unique notifiable disease cases were divided by the population of the indianapolis metropolitan statistical area (msa) to obtain a ratio for estimation of future volume. results we identified a total of 77,199 unique notifiable disease cases. according to 2010 census data, the population of the indianapolis msa is 1,834,672. this produces a ratio of 2,104 elr cases per 100,000 population per year. conclusions roughly 2% of the population had an unique notifiable disease case reported, more than double current rates (4). actual rates could be higher given this analysis eliminated duplicate reports for chronic diseases, such as tuberculosis, hepatitis b and c, and sickle cell disease. the impact on local and state health departments is likely to be significant given scarce resources. although the calculated ratio may stimulate conversations within health departments, it represents an approximate estimator. future work will seek to refine estimation techniques by accounting for acute versus chronic notifiable disease as well as additional factors, such as the notifiable condition and/or the relative size of the hospital sending lab data to the health department. these refined estimators will enable improved planning efforts within state and local health departments. keywords electronic laboratory reporting; public health surveillance; public health informatics; electronic health records acknowledgments this work was funded in part by a grant (5r01hs020209) from the agency for healthcare research and quality. references 1. centers for medicare & medicaid services. medicare and medicaid programs; electronic health record incentive program—stage 2. federal register [internet]. 2012 [cited 2012 august 24]. available from: http://www.ofr.gov/ofrupload/ofrdata/2012-21050_pi.pdf. 2. dixon be, mcgowan jj, grannis sj. electronic laboratory data quality and the value of a health information exchange to support public health reporting processes. amia annu symp proc. 2011;2011:32230. 3. fidahussein m, friedlin j, grannis s. practical challenges in the secondary use of real-world data: the notifiable condition detector. amia annu symp proc. 2011:402-8. 4. centers for disease control and prevention. summary of notifiable diseases: united states, 2009. mmwr morb mortal wkly rep. 2011 may 13;58(53):1-100. *brian e. dixon e-mail: bdixon@regenstrief.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e52, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts data quality: a systematic review of the biosurveillance literature tera reynolds*1, ian painter2 and laura streichert1 1international society for disease surveillance, brighton, ma, usa; 2university of washington, seattle, wa, usa objective to highlight how data quality has been discussed in the biosurveillance literature in order to identify current gaps in knowledge and areas for future research. introduction data quality monitoring is necessary for accurate disease surveillance. however it can be challenging, especially when “real-time” data are required. data quality has been broadly defined as the degree to which data are suitable for use by data consumers [1]. when compromised at any point in a health information system, data of low quality can impair the detection of data anomalies, delay the response to emerging health threats [2], and result in inefficient use of staff and financial resources. while the impacts of poor data quality on biosurveillance are largely unknown, and vary depending on field and business processes, the information management literature includes estimates for increased costs amounting to 8-12% of organizational revenue and, in general, poorer decisions that take longer to make [3]. methods to fill an unmet need, a literature review was conducted using a structured matrix based on the following predetermined questions: -how has data quality been defined and/or discussed? -what measurements of data quality have been utilized? -what methods for monitoring data quality have been utilized? -what methods have been used to mitigate data quality issues? -what steps have been taken to improve data quality? the search included pubmed, isds and amia conference proceedings, and reference lists. pubmed was searched using the terms “data quality,” “biosurveillance,” “information visualization,” “quality control,” “health data,” and “missing data.” the titles and abstracts of all search results were assessed for relevance and relevant articles were reviewed using the structured matrix. results the completeness of data capture is the most commonly measured dimension of data quality discussed in the literature (other variables include timeliness and accuracy). the methods for detecting data quality issues fall into two broad categories: (1) methods for regular monitoring to identify data quality issues and (2) methods that are utilized for ad hoc assessments of data quality. methods for regular monitoring of data quality are more likely to be automated and focused on visualization, compared with the methods described as part of special evaluations or studies, which tend to include more manual validation. improving data quality involves the identification and correction of data errors that already exist in the system using either manual or automated data cleansing techniques [4]. several methods of improving data quality were discussed in the public health surveillance literature, including development of an address verification algorithm that identifies an alternative, valid address [5], and manual correction of the contents of databases [6]. communication with the data entry personnel or data providers, either on a regular basis (e.g., annual report) or when systematic data entry errors are identified, was mentioned in the literature as the most common step to prevent data quality issues. conclusions in reviewing the biosurveillance literature in the context of the data quality field, the largest gap appears to be that the data quality methods discussed in literature are often ad hoc and not consistently implemented. developing a data quality program to identify the causes of lower quality health data, address data quality problems, and prevent issues would allow public health departments to more efficiently and effectively conduct biosurveillance and to apply results to improving public health practice. keywords biosurveillance; data quality; literature review acknowledgments we thank the isds data quality workgroup for initiating this project, which was supported by cdc through contract with the task force for global health. references 1. wang ry, strong dm. beyond accuracy: what data quality means to data consumers. jmis. 1996:5–33. 2. dixon be, mcgowan jj, grannis sj. electronic laboratory data quality and the value of a health information exchange to support public health reporting processes. proc amia symp. 2011;2011:322. 3. redman tc. the impact of poor data quality on the typical enterprise. commun acm. 1998;41(2):79–82. 4. maydanchik a. data quality assessment. technics publications, llc; 2007. 5. zinszer k, charland k, jauvin c, et al. the influence of address errors on detecting outbreaks of campylobacteriosis. emerg health threats j. 2011;4(s59):68–69. 6. chen l, dubrawski a, waidyanatha n, weerasinghe c. automated detection of data entry errors in a real time surveillance system. emerg health threats j. 2011;4(s69):9–10. *tera reynolds e-mail: treynolds@syndromic.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e20, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts extracting surveillance data from templated sections of an electronic medical note: challenges and opportunities adi gundlapalli*1, 2, guy divita1, 2, marjorie carter1, 2, shuying shen1, 2, miland palmer1, tyler forbush1, 2, brett south1, 2, andrew redd1, 2, brian sauer1, 2 and matthew samore1, 2 1va salt lake city health care system, salt lake city, ut, usa; 2internal medicine, university of utah school of medicine, salt lake city, ut, usa objective to highlight the importance of templates in extracting surveillance data from the free text of electronic medical records using natural language processing (nlp) techniques. introduction the main stay of recording patient data is the free text of electronic medical records (emr). while stating the chief complaint and history of presenting illness in the patients ‘own words’, the rest of the electronic note is written by the provider in their words. providers often use boiler-plate templates from emr pull-downs to document information on the patient in the form of checklists, check boxes, yes/no and free text responses to questions. when these templates are used for recording symptoms, demographic information or medical, social or travel history, they represent an important source of surveillance data [1]. there is a dearth of literature on the use of natural language processing in extracting data from templates in the emr. methods a corpus of 1000 free text medical notes from the va integrated electronic medical record (cprs) was reviewed to identify commonly used templates. of these, 500 were enriched for the surveillance domain of interest for this project (homelessness). the other 500 were randomly sampled from a large corpus of electronic notes. an nlp algorithm was developed to extract concepts related to our target surveillance domain. a manual review of the notes was performed by three human reviewers to generate a document-level reference standard that classified this set of documents as either demonstrating evidence of homelessness (h) or not (nh). a rulebased nlp algorithm was developed that used a combination of key word searches and negation based on an extensive lexicon of terms developed for this purpose. a random sample of 50 documents each of h and nh documents were reviewed after each iteration of the nlp algorithm to determine the false positive rate of the extracted concepts. results the corpus consisted of 48% h and 52% nh documents as determined by human review. the nlp algorithm successfully extracted concepts from these documents. the h set had an average of 8 concepts related to homelessness per document (median 8, range 1 to 34). the nh set had an average 2 concepts (median 1, range 1 to 13)”. thirteen template patterns were identified in this set of documents. the three most common were check boxes with square brackets, yes/no and free text answer after a question. several positively and negatively asserted concepts were noted to be in the responses to templated questions such as “are you currently homeless: yes or no”; “how many times have you been homeless in the past 3 years: (free text response)”; “have you ever been in jail? [y] or [n]”; are you in need of substance abuse services? yes or no”. human review of a random sample of documents at the concept level indicated that the nlp algorithm generated 28% false positives in extracting concepts related to homelessness when templates were ignored among the h documents. when the algorithm was refined to include templates, the false positive rate declined to 22%. for the nh documents, the corresponding false positive rates were 56% and 21%. conclusions to our knowledge, this is one of the first attempts to address the problem of information extraction from templates or templated sections of the emr. a key challenge of templates is that they will most likely lead to poor performance of nlp algorithms and cause bottlenecks in processing if they are not considered. acknowledging the presence of templates and refining nlp algorithms to handle them improves information extraction from free text medical notes, thus creating an opportunity for improved surveillance using the emr. algorithms will likely need to be customized to the electronic medical record and the surveillance domain of interest. a more detailed analysis of the templated sections is underway. keywords natural language processing; surveillance; templates; va acknowledgments funding from the us department of veterans affairs (hsr&d); resources from veterans informatics computing infrastructure and va salt lake city health care system and all our research team members who have worked on this project. references 1. delisle, s., et al., combining free text and structured electronic medical record entries to detect acute respiratory infections. plos one, 2010. 5(10): p. e13377. *adi gundlapalli e-mail: adi.gundlapalli@hsc.utah.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e75, 2013 ojphi-06-e91.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 98 (page number not for citation purposes) isds 2013 conference abstracts automated real-time surveillance using health indicator data received at different time intervals joseph lombardo*1, julie pavlin2, christopher cuellar1, yevgeniy elbert1 and jean-paul chretien2 1johns hopkins university applied physics laboratory, laurel, md, usa; 2armed forces health surveillance center, silver spring, md, usa � �� �� �� � � �� �� �� � objective ��������� � ��� �� ������������ ����� ���� �� � � ���������������� ��� �������������� ������������������� ������������ ���������� �� ��������� ������ � ������������� � ������� ���� � introduction ������������ ������ ����� �������! ��� ���� ��� ��������� "�������� � ��#������� ����$�� ���� ��������� ��� �������� ������� ����������� � � ��� ������ ��������� ���������� � ������� �����%�� �� � ��������������� ���� ���������� �������������� ��������� ��� � ����������� ������� � �� �&����� ���������� �� � ��� ���������� ��� �� ������ ����� �����'������� �� ����� ����� � ����� ���(#�"������ ��� ������ �������� ��� ���� �� ����� �����)������� ��� �������� � ��������� ��������� ���� � � ������$� ���������%�� ������ �� �)������� � ������ �� ���� ���������������� � �� ��� ��� ���� ��������� �� ����� �� �� �� ����� ����������������������������� methods *�*��������� �������������� ��������������� � ������� ���� ��' � ��� �������� � ��������� ���� ������� ��������� ������������ �+������ ��� � �� ,��'$*�-./0������)��� ������� ��� ���� �� ������������ ��� � �� ��������� ���� �� ������������ ����� ���������� ���������� � �� ����� ���������������$����� � ���������� �����)���������������� ����� ���� ��� ��������� � ����% �� ����������������� ������� ���� � ������� ���� ����� ������ � ����� �� ����� � ��� �������� �������� � �������������1 ����������� ���� ������� ��������������������� ����� � ������ ���23.4��'�������� �� ��� ����� ����� �� ���� �� � �� ��� ��� ������ ����� ����� �� ����� ����� ��� �� ������� ���� ���� �� ������� �� ���� ���������� results ��������� ��������� ����� ��������������� ��� �� ���� ������� �� � conclusions ����������� ��������������� ��������"�#$������ �������� �� ��� ������� �� �� �� ��� ��������������� ��� ���������������������������� �� ������ ��������������� ���� ������ ����������5����� � ����� ����� �� ���������� ��� ������������� ����� �������� �������������� ���������� �� ���� �������� ����� �� ������������� � �������������� ��������� ����� ���������� �� ���� ������������ � � ���� ���� keywords 6� �� ���� ���������7�* �"�����7�#������� ��� acknowledgments ����������������������� ���������"�������� � ��#������� ����$�� �� *joseph lombardo e-mail: joe.lombardo@jhuapl.edu� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e91, 2014 crappdf.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 140 (page number not for citation purposes) isds 2013 conference abstracts adverse childhood experiences and smoking among urban youths in oyo state, south western nigeria mobolaji m. salawu*1 and eme owoaje1, 2 1community medicine department, university college hospital, ibadan, nigeria; 2college of medicine, university of ibadan, ibadan, nigeria � �� �� �� � � �� �� �� � objective ����������� �� ������ � ��������� ����� ���� ��� �������� �� ���� �������� ������� ���� ���� ����� ��� �� ����� ��� � ��������!� ���� �"���� �#��� ��$ introduction ���� ���� ��� �������� �� ����� ��� ��� ����� ������� �� �� % &��� ���� ���������� ��� ����� ���� ���� ���� ����������� ����� �% ������$�� ���������� ��� ����������������������������� �� ���� � ���� �� ���� ����� ��������� ��� �� � ������ ��������������� ����� ��� ���� ����������� �� ����� ���������� � ��� ������ ����� ���&�� � ������ �$'!(�)���� � �� ���� ������ ���� ����� ���� ��� ��������% �� ����� ������� ������������� ������� ���������� ���� ������� � � � �& ����� ����� ��#��� ��$ methods "���� ���������� ���������� ����� �����&����� ��� �� �� ����� � "���� �#��� ��������� ��������� ���������� !�(*'($�)���� �� ��� �� �������������� ��������������������� ����� �+��$�,�����������% ���������� ��� �� �� ����� ����� ���� ���+������ �� ����������& ��� � ������ ���� ��� �������� �� ����+������ �� ����������������� �� �� �� ��&� �,��������� � ���� ����� ��� !�.���� ��� ��/��� �)���� 0� ���� ��� ����(*''$1!2�3 &� ����� ��� ������� ���� ������� ����� '*������� �����&��������&� ��'4���� ���&������������ ��!�� ������!� � ��������������5������� ���� ��� ������� ������6� ���� �������&� �% ��� ����� ���%��� ���� ���������������� ���� �� �� ���!��� � �������% � ���� 7����� ��!� ���� ���������� ��%�����!� ���� ������ ������� ���� � ��� �� �� ����� ���� ��������� ��� ��1������ ���� ���� ������ � ������!��� �������� ��� ������� %��&� ������'8�� ���� � ������� �� �������$�,������ ��� ���������� ��-����� ��� �('�� ������������ �� �� ������������ ���%����!�� ���+�� �������� ����������� �� ����� $�9����� �&���������������� �&��� ��������������8:$ results ���������&�8;*��� ������ ����� ��� �� ������$�� ����� ������&� ���� �� �������(2$4�2$'���� �$�<��������� ���������8'$2:��&� �% ��� �� ��$����������'������&�'*������� �����&���������� ��� ������� 4=$>:��&� ���� �� ��$�� ������������ ��� ��� ����������� �����% � ���������������82$4:!� ���� ���������� ���������8'$':!���� ���% � ���������������� ���14$4:�� ���� � �������� ���� 7���� ���(1$(:$� ?����� !�� ���8$>:��&� ���� �� ��� ��� ����������������$�"�� �� �� �������� ��&�������������!��� ��� ���� ���������� � ����� ���� �% �� ����� ������� ���&�������@*$*8$���� ��� �������� ���� ���� �!� (4$*:� ������ �������!�(*:�� ������������� ����&� ������'8���� �� � ��'>$':��&�� �� ���� �� ����� ���� � ��������� �$� )���� �� ������ �2�� ��� �������� �����&�������2*$;:�� ��� ���� ���������� ������� ���� ���� ��@*$*8$� �������� ������ � ���� �� ��� ��� �� �� ������!�� ���� ��� �� �� 2�� ��� �������� �����&������ ��������� ������� �� � � �����&�� ���% � ��� ������ ���� ���� �6���� �&��� ���!���� ������������&�� �������� (��������� ������������� �� ���� ��&����� ���� ��� �������� �� ���� ��� ���2�� ��� ��� )�a�($2(5�>8:��3a��'$(;%2$;8���@*$*8$�� ������ �&��� � ��������� �����������&�� �� �� � ����� �� ���� ��&����� ��� ���� �� ����� � ���������2�� ��� ���������'�$ conclusions � � �������� ������������ � ��� ����� ������ � ��������� ������� �� ��������� ������� �$�� � ������� ������� ���� �b�������� ������ �� ��+�� ���������������� ���� �� ������� �#��� ���� ������� ��� � ��� ��������&�������� ���� ��� ������ ������ ������� ������ � ����&� ������ �������&&����$ ������'6������ ���� ����c������������&������ ���� ����� ����������� ���7 ���� ��&����� ���� ��� ���������� ��$ ��%���c������&� ����!��� �� !��������� keywords ���� ���� ��� �������� �� ���5������ �5�#��� ��5�/��� � acknowledgments ����� ����d����� ��,��� ��� �!�.�?!�3���� 3���� �#� � �9�����e��� �� �!� �������� ���������d� ��� ���&�?���� !������!�3���� !� �������� references '$ � ���)�'�6>1%>4$ ($ )��� ��9�!�d�� ���0g!�0 �� �,"$����� ���� ��� �������� �� ���� ������� �� ���� % ������ ���� ����� ���������� ����������� ����� � �� ����� �$�� ����������h�#�������(*'*512642(%488$ 1$ �,�$��� �� ��&� �,��������� � ���� ����� ��� !�,��� ��� ���&� ?���� �� ��?��� ��� �����$����� ���� ��� �������� �� ���������$� (**85� ���677���$���$���7 ���� �7���7+������ �� ��$ ��$� 2$ �,�$��� � ���&� �,��������� � ���� ����� ��� $�#���� ���/��� � )����0� ���� ��� ���$�(*''5� ���677���$���$���7 ���� ����� 7� ��7 +������ �� �i ���� ���$ ��$ *mobolaji m. salawu e-mail: sannibolaji@yahoo.com� � � � 140 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e9, 2014 public health and health information exchange: the indiana experience leveraging health information exchange to support public health situational awareness: the indiana experience 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 leveraging health information exchange to support public health situational awareness: the indiana experience shaun j. grannis 1,2 , kevin c. stevens 3 , ricardo merriwether 2 1 the regenstrief institute 2 indiana university school of medicine 3 marion county health department, indiana abstract public health situational awareness is contingent upon timely, comprehensive and accurate information from clinical systems. ad-hoc models for sending non-standard clinical information directly to public health are inefficient and increasingly unsustainable. information sharing models that leverage health information exchanges (hies) are emerging. hies standardize, aggregate and streamline information sharing among data partners, including public health stakeholders, and hie has supported public health practice in indiana for more than 10 years. to accelerate nationwide adoption of hie-supported situational awareness processes, the cdc awarded three hies across the nation, including indiana, new york and washington/idaho. the indiana partners included indiana university school of medicine, regenstrief institute, indiana health information exchange, indiana state department of health, health & hospital corporation of marion county, and children’s hospital boston. activities included augmenting biosurveillance processes, enabling bi-directional communication, enhancing automated detection of notifiable conditions, and demonstrating technological advances at national forums. hie transactions destined for public health were enhanced with standardized clinical vocabulary and more complete physician contact information. during the 2009 h1n1 flu outbreak, the hie delivered targeted public health broadcast messages to providers in marion county, indiana. we will review the partnership characteristics, activities, accomplishments and future directions for our health information exchange. keywords: health information exchange, situational awareness, biosurveillance, syndromic surveillance, influenza. introduction under an initiative entitled “accelerating situational awareness through health information exchange” the centers for disease control and prevention (cdc) partnered with an indiana coalition including the indiana state department of health (isdh), the marion county health department (mchd) in indianapolis, the regenstrief institute (ri), indiana university (iu), and children’s hospital boston. coalitions from new york and washington/idaho also partnered with the cdc, and the combined groups are collectively referred to as the “cdc hie leveraging health information exchange to support public health situational awareness: the indiana experience 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 collaborative.” the cdc charged the collaborative with exploring methods for sharing information between public health and clinical entities to support public health situational awareness and case reporting in the context of the emerging nationwide health information network (nhin). this paper summarizes the activities of the indiana coalition. partners the organizational characteristics of the contract participants are described below. regenstrief institute, inc. – in 1969 philanthropist samuel n. regenstrief established the regenstrief institute to conduct and facilitate medical research, medical education and clinical care. as a supporting organization of indiana university, regenstrief is an internationally recognized informatics and healthcare research organization dedicated to improving health through research that enhances the quality and cost-effectiveness of health care. the institute employs approximately 150 full-time staff in addition to 35 investigators and affiliated researchers who are faculty members of indiana university. indiana university school of medicine – indiana university’s medical school was established in 1903 and is one of the nation's largest medical centers. the indianapolis campus includes indiana's only medical and dental schools and the nation's largest nursing school. iu medical school supports three adult hospitals (university, wishard, and roudebush veteran's), a pediatric hospital (james whitcomb riley hospital for children), a health center (regenstrief institute for health care) and a number of unique teaching and research facilities. indiana health information exchange (ihie) – in 2004 ihie was incorporated in the state of indiana as a non-profit company. ihie is extending and scaling the principles and infrastructure devised, demonstrated, and built by the regenstrief institute. ihie works hand-in-hand with regenstrief to create sustainable business models and provide commercial support for the institute’s technologies in the marketplace. ihie has grown more than 50 employees and continues to add new data sources and new customers each month. ihie provides a clinical results delivery service called docs4docs® that transmits more than 1.4 million electronic clinical results per month to over 19,000 physicians. because clinical workflow and health information technologies are highly varied, the transmission of results is tailored to accommodate specific workflows by delivering results directly to emr’s, web portals, and other receipt mechanisms. additional services that leverage the hie infrastructure are being launched. indiana state department of health (isdh) – the indiana state department of health, founded as the state board of health in 1881, supports indiana's economic prosperity and quality of life by promoting, protecting, and providing for the health of hoosiers in their communities. in addition to providing epidemiological support to most of the local health departments in the state, isdh offers a full complement of skills including epidemiology, information technology and program management. the department’s headquarters are located in downtown indianapolis. health & hospital corporation of marion county (hhc) -for over 50 years hhc of marion county has served as the public health and hospital system for marion county, indiana. leveraging health information exchange to support public health situational awareness: the indiana experience 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 hhc operates the marion county health department (mchd) and wishard health services (whs). mchd is indiana’s largest local health department and provides a variety of services to improve population and environmental health. whs is the public hospital and healthcare system for uninsured and underinsured residents of marion county. hhc is mandated by the indiana general assembly to provide medical services to all residents of marion county, regardless of ability to pay. a seven-member board of trustees, appointed by the mayor of indianapolis, the city-county council, and the county commissioners, governs hhc. the director and most of the medical staff at the mchd are faculty at the indiana university school of medicine. children’s hospital boston (chb) – founded in 1869, chb is home to the world's largest research enterprise based at a pediatric medical center. the children’s hospital informatics program at the harvard-mit division of health sciences and technology (chip) is a core program of the center for biomedical informatics at harvard medical school, and a core program of the nih funded national center for biocomputing, a cornerstone of the nih roadmap initiative. chip investigators lead several regional and national efforts in public health surveillance, data integration across multiple hospitals, and personally controlled health records. activities summary activities supported by the cdc hie collaborative were grouped according to major tasks and included 1.) biosurveillance, 2.) technical demonstrations, 3.) aggregate summary data exchange, 4.) delivering public health alerts, 5.) pre-populated reporting forms, 6.) enhancing automated notifiable condition detection, and 7.) improving data quality for public health. the following sections provide an overview of activities in each of these areas. 1. biosurveillance a number of successful activities helped to augment traditional public health surveillance. extracting public health concepts from free-text data: many conditions of interest to public health are recorded in widely varying free-text formats. we developed natural language processing and other information extraction methods to identify concepts in non-standard freetext reports. concepts that suggest the presence of a condition of interest to public health (e.g., the term “miliary” in a chest x-ray report suggests tuberculosis) can augment syndromic surveillance data streams. resource utilization monitoring: hospital bed utilization data is often gathered by manual data entry, which further encumbers already overburdened personnel. we created a prototype process to evaluate the feasibility of characterizing hospital bed utilization using existing admission, discharge and transfer (adt) messages received by the hie. we confirmed the ability to gage bed utilization trends at participating hospitals in a predictable fashion using these transactions. assessing the minimum biosurveillance data set (mbds): from 2006 to 2008 the american health information community (ahic), a national subject matter expert panel, established a minimum biosurveillance data set (mbds) containing a representative collection of data elements to support public health surveillance processes. to assess the utility and feasibility of leveraging health information exchange to support public health situational awareness: the indiana experience 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 using this data set, we completed a technical review of the data elements by first mapping data fields from the existing hie transactions to specific mbds elements and second, we determined the percent completeness for each data element in the current operational data flow. ems and inpatient surveillance: while the hie infrastructure continues to support the indiana public health emergency surveillance system (phess) by delivering minimum biosurveillance data set (mbds) elements from 83 indiana hospitals, we also seek other useful surveillance sources. in addition to traditional surveillance we developed a strategy to exchange hie data with emergency medical services (ems) mobile units, supporting surveillance in the prehospital phase. developing additional ems interfaces and incorporating additional data feeds from ambulatory care facilities are ongoing. to enhance indiana’s public health surveillance activities, in 2010 we began leveraging the hie data network to collect inpatient chief complaint data and currently transmit this data to isdh every 3-hours. because we could leverage existing infrastructure, we were able to develop data feeds from more than 50 hospitals in less than 3 months. evaluating open source syndromic surveillance tools: in partnership with children’s hospital boston, we locally deployed and evaluated an open source surveillance tool called automated epidemiologic geotemporal integrated surveillance system (aegis). this work resulted in documents describing surveillance systems and a technical characterization of aegis. 2. technical demonstrations in the face of newly created interoperability specifications there is a need to demonstrate the feasibility of deploying new technology. the cdc hie collaborative demonstrated the federal biosurveillance interoperability use-case at the 5 th nhin forum on december 15, 2008 in washington, d.c. where indiana representatives from regenstrief, mchd and isdh demonstrated syndromic surveillance data exchange using the newly designed nhin gateway. in february 2009 regenstrief demonstrated the ihe personnel white pages (pwp) profile, which provides access to basic human workforce user directory information. also demonstrated at the integrating the healthcare enterprise (ihe) connect-a-thon in chicago were the hitsp constructs t63 (emergency message distribution element transaction), t64 (identify communication recipients transaction), c84 (consult and history & physical note component), c82 (emergency common alerting protocol component), and t81 (retrieval of medical knowledge transaction). in august 2009, the cdc hie collaborative and the cdc demonstrated the biosurveillance situational awareness use case at the cdc-sponsored public health information network (phin) conference in atlanta. 3. aggregate summary data exchange we reviewed the workflow and existing technical systems for identifying and transmitting public health reportable case data including influenza, influenza-like-illness (ili) and pneumonia. the cdc hie collaborative worked closely with cdc stakeholders to create an aggregated data collection format that is used to send data through the nhin connect gateway. this aggregated data collection format is named the geocoded interoperable population summary exchange (gipse). this format was deployed in september 2009 to send data to the cdc. its first use was to provide local, state and cdc stakeholders with h1n1 surveillance data stratified across leveraging health information exchange to support public health situational awareness: the indiana experience 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 covariates including age, gender, and geography using a variety of case definitions for ili and influenza as defined by hie and cdc stakeholders. 4. delivering electronic public health alerts to physicians public health organizations must communicate with clinical care systems for a variety of purposes including case reporting and management, biosurveillance and situational awareness data sharing, and public health alerting. traditional methods for communicating between public health and clinical entities using telephone, fax, and u.s. postal service often are cumbersome, delayed and inefficient. and although e-mail is a potential option for delivering public-health communications to clinicians, it remains unclear whether e-mails are received in a timely fashion due to several factors including unintentional e-mail filtering, invalid or outdated addresses, and a lack of a reliable mechanism for tracking receipt of such information. to deliver public-health alerts to directly to clinicians in a manner that seamlessly integrates into their workflow, we developed technology that appends public health messages to the existing clinical results delivery service that currently delivers 1.4 million clinical results per month to over 19,000 physicians. we designed, implemented, tested and deployed a public-health alerting system that was first used during the h1n1 influenza outbreak to quickly reach over 3,000 physicians in marion county. in addition to broadcasting to all physicians, the system can target customized combinations of physician specialties and geographic regions. 5. delivering pre-populated public health reporting forms to physicians to address physician under-reporting of public health notifiable conditions we developed a prototype system that generates and delivers electronic pre-populated reportable forms to providers using the docs4docs®clinical messaging system. the system the clinical messaging sends all manner of clinical results to providers who receive them either as a fax, through a designated web-portal or directly into an ehr. the reportable forms system prepopulates the required indiana reporting forms for reportable diseases and sends the form to physicians at the same time they receive the positive lab result. we hypothesize that because pre-populated forms will reduce the information gathering burden associated with reporting, physician reporting rates will improve when presented with such a form. future work will evaluate this intervention. 6. enhancing automated notifiable condition detection building on standards for message structure and content (hl7 and loinc®), the regenstrief institute has implemented and maintained an automated notifiable condition reporting system for more than 10 years. the system receives real-time hl7 clinical results from a variety of hie stakeholders, and automatically translates disparate proprietary codes into standard loinc codes. it then determines whether the results carried by the message indicate a notifiable condition by checking the abnormal flag sometimes contained in the message, or by comparing the test results with criteria in the phin notifiable condition mapping table. we evolved our existing infrastructure to create a modular notifiable condition processor re-usable by other health information exchanges and public health stakeholders. in may, 2009 we were pleased to deliver the notifiable condition detector (ncd) version 1.0 and condition detectors for shigella, salmonella and mrsa as an openmrs module in both binary and source code formats. the newly enhanced system currently processes up to 300,000 transactions daily and automatically leveraging health information exchange to support public health situational awareness: the indiana experience 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 detects and transmits up to 450 public health notifiable conditions daily to local and state health departments. 7. improving data quality for public health clinical transactions often lack all fields necessary to fully support public health practice. we built and deployed methods within the hie to enhance the quality of data sent to public health. two approaches are described below. automated loinc mapping: we worked with the hl7 standards development process to advocate for a new coded element data type (cwe) that permits up to three synonymous vocabulary terms in the hl7 observation identifier field (obx-3). this enhancement provides greater capacity for sending multiple synonymous code sets, and was necessary to incorporate logical observation identifiers names and codes (loinc ® ) into hie transactions. to standardize hie data for public health uses, we deployed an ongoing process to automatically transform non-standard inbound codes into loinc ® codes. enhancing provider data: because identifying physician information helps speed public health case management processes, we leveraged a master provider file to enhance incomplete provider information for incoming message streams. this process increases completeness of the provider telephone number by more that 40%. providing mchd with this information allows epidemiologists to perform case management functions more efficiently. conclusions as this work continues, we will advance the quality and quantity of clinical data and will seek methods for providing public health personnel with increasingly seamless and direct access to the hie data repository for approved purposes. after completing provider enhancement, we will focus on enhancing patient data using the hie global patient registry. this will allow public health to have complete patient information for case reporting. these and other technological advancement will be the benchmark for a hie to send clinical data to public health and the cdc through the nhin. the longstanding, successful indiana coalition has developed leading-edge technologies that clearly demonstrate the feasibility and value of leveraging hie to support a variety of public health use cases. by re-using hie for public health purposes we have made substantive meaningful improvements in the quality and quantity of clinical data that is currently being exchanged with public health. specifically, provider information that is often missing or incomplete has been improved so public health doesn’t have to search for the information. further, by participating in demonstrations at the ihe, himss and phin annual conferences, we were able to highlight the biosurveillance detection and monitoring scenarios to various audiences. moreover, using public health alerting and pre-populated forms as prototypes, we have enabled rapid and seamless bidirectional communication between public health and clinical care systems. this framework presents a host of new opportunities to increasingly support public health practice. by connecting stakeholders from clinical care and public health organizations through comprehensive, sustained activity, we will advance the digital channels leveraging health information exchange to support public health situational awareness: the indiana experience 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 and trust relationships that are necessary to establish the next generation of infrastructure that will meaningfully support increasingly complex public health processes. conflicts of interest the authors have no conflicts of interest to report at this time. acknowledgments this project was funded by the centers for disease control & prevention under contract 2002008-24368. the content of this publication does not necessarily reflect the views or policies of the department of health and human services, nor does mention of trade names, commercial products, or organizations imply endorsement by the u.s. government. correspondence shaun j. grannis, md, ms, faafp sgrannis@regenstrief.org overcoming data challenges examining oral health disparities in appalachia online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 overcoming data challenges examining oral health disparities in appalachia denise d. krause 1 , warren l. may 1 , jeralynne s. cossman 2 1 university of mississippi medical center 2 mississippi state university abstract objective: the objective of our study of oral health disparities in appalachia was to use existing data sources to geographically analyze suspected disparities in oral health status in the 420 counties of appalachia, and to make sub-state comparisons within appalachia and to the rest of the nation. the purpose of this manuscript is to describe the methods used to overcome challenges associated with using limited oral health data to make inferences about oral health status. methods: oral health data were obtained from the behavioral risk factor surveillance system (brfss). because the brfss was designed for state-level analysis, there were inadequate numbers of responses to study appalachia by county. we set out to determine the smallest possible unit we could use, aggregating data to satisfy cdc minimum requirements for spatially identified responses. for sub-state comparisons, data were first aggregated to appalachian and non-appalachian regions within appalachian states. next, urban versus rural areas within appalachian and non-appalachian regions were examined. beale codes were used to define metropolitan and non-metropolitan statistical regions for the united states. results: aggregating the data as described proved useful for smoothing the data used to analyze oral health disparities, while still revealing important sub-state differences. using geographic information systems to map data throughout the process was very useful for determining an effective approach for our analysis. discussion: studying oral health disparities on a regional or national level is difficult given a lack of appropriate data. the brfss can be adapted for this purpose; however, there is a limited number of oral health questions and because they are also optional, they are not routinely asked by all states. expanding the brfss to include a larger sampling frame would be very helpful for studying oral health disparities. conclusions: novel techniques were introduced to use brfss data to study oral health disparities in appalachia, which provided informative sub-state results, useful to health planners for targeting intervention strategies. keywords: behavioral risk factor surveillance system (brfss), beale codes, oral health, disparities, geographic information systems (gis) http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 introduction the surgeon general’s report “oral health in america” declared that no less than a “silent epidemic of oral disease is affecting our most vulnerable citizens poor children, the elderly, and many members of racial and ethnic minority groups.” 1 there are many factors which affect equitable access to oral health care. understanding those inequities is a prerequisite to eliminating them. for example, socioeconomic status is a key factor contributing to oral health disparities among population subgroups in the u.s. people living in rural areas also experience oral health disparities disproportionately. despite improved care over the last 20 years 2 , dental care is still identified as the primary health need of u.s. children. 3 due to lack of care and inadequate preventive measures, childhood caries (also known as tooth decay) are the most common chronic disease among children—in fact, it is five to eight times more common than asthma. 4 even more alarming is the concentration of childhood caries: 80% of dental caries are found in 25% of children, most of whom are from lower socioeconomic households. 5 appalachia is a rural region known to be economically disadvantaged. as with other health indicators, oral health care exhibits disparities within the region. funding was provided by the appalachian regional commission to use existing data sources to geographically analyze suspected disparities in oral health status in the 420 counties that make up appalachia, and to make sub-state comparisons within appalachia, and to the rest of the nation. as a part of the overall study, we also examined relationships between oral health disparities, socioeconomic status indicators, and other indicators in that area. details of the comprehensive analysis are reported elsewhere. 6 unfortunately, there is a paucity of available data relating to oral health status, in appalachia, or the nation as a whole. we describe the methodology used to overcome challenges associated with limited availability of oral health data in an effort to make informed inferences about oral health status in the appalachian region. geographic visualization techniques were used to assess the usefulness of the oral health data throughout the project and to define a strategy for producing useful results. http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 figure 1. percentage of respondents to the behavioral risk factor surveillance system survey reporting ‘no’ to having had a dental visit within the past year. brfss data are presented at the state level. sources: centers for disease control, u.s. department of health and human services, 2008. methods the only known publicly available and readily accessible data source we could obtain to test sub-state oral health disparities was the behavioral risk factor surveillance system (brfss). the brfss survey is a continuous telephone health survey system which is used for monitoring health conditions and health-risk behaviors across the united states. the brfss provides highquality state-level data that informs policymakers of regional disparities in both health conditions and positive health practices (figure 1). this survey, however, was not intended to be used for small area, or sub-state, estimates. recently, there has been attention placed on developing statistical methodology using brfss data for small area estimation, such as health district or county-level analyses. 7-12 the topic of oral health presents a special challenge. unfortunately, there are only a few common questions pertaining to oral health included in the brfss survey 13 . oral health questions are: 1. how long has it been since you last visited a dentist or dental clinic for any reason? 2. how many of your permanent teeth have been removed because of tooth decay or gum disease? do not include teeth lost for other reasons, such as injury or orthodontics. 3. how long has it been since you had your teeth cleaned by a dentist or dental hygienist? additionally, these oral health questions have been included only as an optional module of the http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 survey and have not been asked every year in every state, due to the overall length and expense of the survey. it is left to the discretion of individual states to decide whether to use the optional modules in any given year, and then they must have a budget to cover the additional expense. this can be especially problematic for poorer states, such as some of those in appalachia. ultimately, this leads to difficulty obtaining large enough sample sizes for annual county-level analysis. the centers for disease control (cdc) requires at least 50 responses per county to use that question’s responses for any given survey year. that means that very high response rates may be necessary in some rural counties for their data to be usable. to examine the oral health data at the county level, we merged county identifiers obtained from the cdc with brfss responses. to aid in addressing the small sample limitation, we combined eight years (1999-2006) of data from the brfss to increase sample sizes at the county level. we used the survey question inquiring as to whether a person had a dental visit in the last 12 months. additionally, we used the brfss coding scheme for the oral health indicator reporting the number of teeth that have been removed and imputed age, to recode variables as "any teeth removed for ages 35-44", "six or more teeth removed for ages 35-44", and "all teeth removed for age 65 and over". all three of these indicators refer to tooth loss attributed to decay or gum disease, not to injury or orthopedic treatment. this provided information on adult oral health status (any tooth loss or significant tooth loss), and senior oral health status (complete tooth loss). participants with missing data (coded "9" or system missing) were eliminated. raw proportions were examined for trends that would preclude using the combined estimates. sas v 9.1.3 was used to combine the data, and the survey procedures in sas were used to find countylevel estimates by including the cdc final weights 14 and pre-defined strata in the estimation process. a geographic information system (gis) was built with sociodemographic and oral health data, and these data were mapped using esri arcgis 9.3 software. for the purposes of this paper, we illustrate the methodology by presenting maps pertaining to only one of the three oral health variables used for the overall study (dental visit in the past year). the dental visit variable has far more responses than the other oral health variables. even using the variable with the greatest number of responses, we faced sample size limitations for county-level analysis. these challenges were greatly exacerbated for the other oral oral health variables on tooth loss. our original intention was to attain adequate sample sizes to estimate prevalence at the county level after combining multiple years of brfss data. by mapping oral health indicators at the county level, it became evident that geographic areas larger than counties would have to be considered to obtain sufficient sample sizes. county-level estimates were not feasible according to the cdc guidelines, even after combining several years of survey data, as many counties still had fewer than 50 respondents (figure 2). as shown in figure 2, many of the more rural counties and those states that did not participate in collecting oral health data in optional years proved to be most difficult in obtaining a clear picture of regional oral health. at this point, the only sub-state comparison we could make using oral health data with more than 50 respondents was a comparison of appalachian regions to non-appalachian regions, within appalachian and non-appalachian states. the 420 counties of appalachia were identified using http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 designations established by the appalachian regional commission. again, estimates of prevalence for counties with 50 or more responses were mapped. this time counties with fewer than 50 were classified with the rest of the appalachian or non-appalachian region of the state (figure 3) in an effort to provide at least some information for those counties that could not be shown due to limitations of sample size. this provided a more local view of some areas where data were available, but proved to be somewhat difficult to interpret. figure 2. brfss data (1999-2006) mapped showing respondents of all ages who had a dental visit within the past year, for all u.s. counties. even after combining eight years of data, many counties had inadequate number of responses to be included in the analysis. the appalachian region is outlined in blue. http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 figure 3. brfss oral health indicator for having had a dental visit within the past year, aggregated to obtain 50 or more responses. some counties have an adequate number of responses. others are aggregated to the appalachian / non-appalachian portions of the states. the appalachian region is outlined in blue. to more clearly represent these data and further expand our analysis, we set out to determine the smallest possible unit we could use, aggregating brfss data to satisfy cdc minimum http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 requirements. because we suspected that dental services vary depending on urban or rural settings, we decided to examine metropolitan versus non-metropolitan areas within appalachian and non-appalachian regions. beale codes, developed by the u.s. department of agriculture 15 , were used to define the metropolitan and non-metropolitan statistical regions for sub-state comparisons within the appalachian region and across the united states. beale codes form a classification scheme that distinguishes metropolitan counties by size and non-metropolitan counties by degree of urbanization and proximity to metropolitan areas. instead of typical ruralurban classifications based on population density, beale codes account for proximity to metropolitan areas and, therefore, to potentially greater access to care. 15 each survey response that reported county of residence was assigned a beale code and an appalachian code. again, due to sample size issues, we combined the nine categories of the original beale classifications so that codes 1-3 represent metropolitan areas and codes 4-9 represent non-metropolitan areas. these designations are shown in figure 4. the prevalence for each oral health indicator was then calculated for each of the following groups: (1) appalachian/ metropolitan, (2) appalachian/non-metropolitan, (3) non-appalachian/metropolitan, and (4) nonappalachian/non-metropolitan. figure 4. metropolitan and non-metropolitan areas defined using beale codes. http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 all counties in west virginia are within the appalachian region. since west virginia data did not meet county-level minimum requirements, west virginia has prevalence estimates only for metropolitan and non-metropolitan regions. other states have both appalachian and non-appalachian counties. after aggregating and weighting the data to the larger geographic areas just described, we were able to obtain valid (n > 50) contiguous data, and oral health indicators could be mapped and compared to national averages (figure 5). figure 5. brfss data aggregated to metropolitan and non-metropolitan areas defined by beale codes, showing the proportion of respondents who had a dental visit within the last year for all u.s. counties, with the appalachian region outlined in blue. results figure 1 shows the more typical state-level presentation of brfss data, a graphical view of the percentage of persons who had a dental visit within the past year for all states. of the appalachian states, mississippi had the lowest percentage of dental visits, followed by west virginia, and kentucky. however, the presentation of brfss data at the state-level provides no meaningful differences on sub-state differences. after combining multiple years of brfss data, we mapped the oral health indicators at the county level. figure 2 illustrates the geographic distribution of dental visits as an oral health indicator for only those counties with sample sizes large enough to meet the cdc guidelines. there was a tremendous amount of missing data and it was clearly not possible to conduct this http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 study at the county level, with such sparse data. we did not have enough data for about half of the counties of appalachia. we then aggregated those counties that did not have the needed 50 or more responses into larger areas of appalachia/non-appalachian portions of the states. figure 3 provides a more detailed picture of the appalachian region. at this point, again we see that mississippi, eastern kentucky, and west virginia were areas of greatest concern, with one large county in north mississippi and two counties in west virginia especially standing out. to make the analysis easier to interpret and more informative, we decided to make rural vs. urban distinctions, further refining the county-level maps by aggregating the counties into metropolitan and non-metropolitan areas, using beale codes. thus, we created four groups for analysis: (1) appalachian/metropolitan, (2) appalachian/non-metropolitan, (3) nonappalachian/metropolitan, and (4) non-appalachian/non-metropolitan. states that surround the appalachian region were also mapped for comparisons (figure 4). figure 5 shows the utility of mapping metropolitan/non-metropolitan areas in helping to smooth the oral health data. regions of mississippi, eastern kentucky and west virginia, had low rates of dental visits, but, now, using beale codes, we can also see that most of the areas with poorer oral health status (as we measure it), were non-metropolitan areas. furthermore, other areas within the appalachian region showed rates similar to the rest of the 48 contiguous united states. the map also reveals apparent differences between the appalachian region of mississippi in the northeast corner of the state, with slightly higher rates of dental visits, and the central and delta regions of the state. note that mississippi, arkansas and okalahoma had large nonmetropolitan areas where dental visits were at a lower rate than metropolitan areas, a potential indicator of lack of access to care. discussion and limitations oral health data are difficult to obtain for small area estimation. while a county-level analysis of oral health indicators would have been ideal, it proved impossible due to limitations with the availability and accessibility of oral health data. the brfss is an extensive and large national dataset that includes oral health questions. however, we found that there were not enough responses to perform county-level analysis for oral health indicators even after combining multiple years of brfss data. unfortunately, the oral health questions are optional and, therefore, are not asked every year in every state. ultimately, to perform sub-state analyses, we aggregated appalachian vs. non-appalachian regions within appalachian states. then, using beale codes, we also examined metropolitan and non-metropolitan differences, while adjusting for poverty. using brfss data, we were able to make estimations smaller than the state level, but not as small as the county or local level, which would have been preferable. there is wide variation in health status throughout the appalachian region and we were not able to detect local differences using brfss data. however, by using the method described, we were able to conduct informative analyses about oral health in the appalachian region at this sub-state level, examining metropolitan/non-metropolitan differences, and to make further comparisons between appalachia and the rest of the nation. 6 http://ojphi.org/ overcoming data challenges examining oral health disparities in appalachia 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 there is a pressing need for better oral health data to study oral health status and to measure the effectiveness of funded initiatives, nationally, and specifically in the appalachian region. the brfss is a valuable source of data, but it has its limitations for small area estimation as we have shown here. discussions should begin with the centers for disease control (cdc) to modify the sampling procedures used for the brfss to collect consistent responses to oral health questions each year in all states. a larger sampling frame would provide the data needed to better inform public health planners and politicians of what areas or population groups should be targeted to improve oral health conditions in appalachia. conclusion aggregating the data as described proved useful for analyzing oral health disparities in appalachia, while still revealing important sub-state differences. using gis to map data provided very useful “views” of the data that helped determine the best methodological approach for conducting this study and provided interesting visual results of the comparisons of oral health indicators in appalachia. mapping the data also helped visualize that low socioeconomic status and rurality contribute to oral health disparities in appalachia. figures 1-5 illustrate the process we used to glean meaningful information from limited oral health data. maps are presented of only one of the oral health indicators obtained from the brfss and used for our analysis of oral health disparities in appalachia. we began the process with brfss data intended for state use (figure 1) and ended up with four groups for analysis. the oral health variable, dental visit within the past year, is presented in figure 5, showing differences in metropolitan/non-metropolitan areas. the brfss can be a useful data source for studying a number of health topics, but may require some small area estimation techniques such as those described here, to overcome data challenges, especially on health topics not included as core questions in the brfss survey. using brfss health data and these methods to examine oral health disparities in appalachia, we were able to to make some interesting observations about oral health disparities in appalachia for policymakers and health planners, identifying areas of concern for targeted intervention strategies. corresponding author denise d. krause associate professor university of mississippi medical center email: dkrause@umc.edu http://ojphi.org/ mailto:dkrause@umc.edu overcoming data challenges examining oral health disparities in appalachia online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 references 1. satcher d. oral health in america: a report of the surgeon general. in: u.s. department of health and human services, editor. rockville, md: national institute of dental and craniofacial research, national institutes of health; 2000. 2. brown lj, wall tp, lazar v. trends in untreated caries in permanent teeth of children 6 to 18 years old. j am dent assoc. 1999;130(11):1637-44 contd. epub 1999/11/26. pubmed pmid: 10573947. 3. newacheck pw, hughes dc, hung yy, wong s, stoddard jj. 2000. the unmet health needs of america's children. pediatrics. 105(4 pt 2), 989-97. epub 04 2000. 4. mouradian we, wehr e, crall jj. 2000. disparities in children's oral health and access to dental care. jama. 284(20), 2625-31. epub 11 2000. http://dx.doi.org/10.1001/jama.284.20.2625 5. edelstein bl. disparities in oral health and access to care: findings of national surveys. ambulatory pediatrics : the official journal of the ambulatory pediatric association. 2002;2(2 suppl):141-7. epub 2002/04/13. pubmed pmid: 11950385. 6. krause dd, may wl, lane nm, cossman js, konrad tr. an analysis of oral health disparities and access to services in the appalachian region. in: appalachian regional commission, editor. washington, d.c. 2012. 7. jia h, muennig p, borawski e. 2004. comparison of small-area analysis techniques for estimating county-level outcomes. am j prev med. 26(5), 453-60. epub 05 2004. doi:http:// dx.doi.org/10.1016/j.amepre.2004.02.004. 8. jia h, link m, holt j, mokdad ah, li l, et al. 2006. monitoring county-level vaccination coverage during the 2004-2005 influenza season. am j prev med. 31(4), 275-80. epub 09 2006. doi:http://dx.doi.org/10.1016/j.amepre.2006.06.005. 9. congdon p. 2009. a multilevel model for cardiovascular disease prevalence in the us and its application to micro area prevalence estimates. int j health geogr. 8, 6. epub 02 2009. doi:http:// dx.doi.org/10.1186/1476-072x-8-6. 10. li w, land t, zhang z, keithly l, kelsey jl. 2009. small-area estimation and prioritizing communities for tobacco control efforts in massachusetts. am j public health. 99(3), 470-79. epub 01 2009. doi:http://dx.doi.org/10.2105/ajph.2007.130112. 11. schneider kl, lapane kl, clark ma, rakowski w. 2009. using small-area estimation to describe county-level disparities in mammography. prev chronic dis. 6(4), a125. epub 09 2009. 12. zhang z, zhang l, penman a, may w. 2011. using small-area estimation method to calculate county-level prevalence of obesity in mississippi, 2007-2009. prev chronic dis. 8(4), a85. epub 06 2011. 13. office of surveillance, epidemiology, and laboratory services. questionnaires: centers for disease control and prevention; 2011 [cited 2012 10/10/2012]. available from: http:// www.cdc.gov/brfss/questionnaires/index.htm. 14. office of surveillance, epidemiology, and laboratory services. brfss annual survey data: centers for disease control and prevention; 2012 [11/27/2012]. available from: http:// www.cdc.gov/brfss/technical_infodata/weighting.htm. 15. economic research service. rural-urban continuum codes: united states department of agriculture; 2004 [updated november 3, 2004april 18, 2012]. available from: http:// www.ers.usda.gov/data/ruralurbancontinuumcodes/. http://ojphi.org/ http://dx.doi.org/10.1001/jama.284.20.2625 http://dx.doi.org/10.1016/j.amepre.2004.02.004 http://dx.doi.org/10.1016/j.amepre.2004.02.004 http://dx.doi.org/10.1016/j.amepre.2006.06.005 http://dx.doi.org/10.1186/1476-072x-8-6 http://dx.doi.org/10.1186/1476-072x-8-6 http://dx.doi.org/10.2105/ajph.2007.130112 http://www.cdc.gov/brfss/questionnaires/index.htm http://www.cdc.gov/brfss/questionnaires/index.htm http://www.cdc.gov/brfss/technical_infodata/weighting.htm http://www.cdc.gov/brfss/technical_infodata/weighting.htm http://www.ers.usda.gov/data/ruralurbancontinuumcodes/ http://www.ers.usda.gov/data/ruralurbancontinuumcodes/ http://ojphi.org/ http://www.cdc.gov/brfss/questionnaires/index.htm http://www.cdc.gov/brfss/technical_infodata/weighting.htm http://www.ers.usda.gov/data/ruralurbancontinuumcodes/ layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts the activity of rabies vaccines against genetic clusters of rabies virus circulating at the territory of ukraine mykola ivanov*, ivan polupan and oleg deryabin institute of veterinary medcine, kyiv, ukraine objective to identify the presence of genetic clusters of rabies virus at the territory of ukraine and to determine the degree of activity of rabies vaccines against these genetic clusters. introduction to develop and implement an effective program of rabies eradication in ukraine in 2008 was founded the unique collection of samples of pathological materials confirmed as positive in rabies at the regional veterinary laboratories of ukraine. the collection is constantly updated and to present moment it includes 1389 samples from all regions of ukraine, selected from 17 animal species and humans. methods identification of the rabies virus in samples of pathological material for their further selection was carried out using the test developed by us which based on rt-pcr with primers complementary to the conservative fragments of the 5’-end of nucleoprotein gene of rabies virus. for the study of the street rabies virus isolates from the collection we use rt-pcr with the primers pair (509, 304) flanking the variable 3’-end part of nucleoprotein gene of the reference strain of rabies virus cvs (fragment in 377 bp). studies of rabies vaccines activity were carried out with modified method of u.s. national institutes of health using rabies virus street isolates of both genetic clusters instead of the challenge virus standard (cvs). all isolates of street rabies virus were inoculated in a dose of 5–50 ld50. the criteria for evaluation of protective activity of rabies vaccine was effective dose (lg ed50). results in molecular genetic studies with variant-specific primers we established the presence in ukraine of two clusters of rabies virus. clusters i circulates on the right bank of the dnipro river (the largest water barrier that divides the country into eastern and western side), and cluster ii – on the left bank of the dnieper. the relationship of these variants with the epizootic situation was researched. for this purpose epizootological zoning of ukraine according to the intensity of the epizootic situation in 2005-2009 was carried out. as a result of this analysis all the regions of ukraine belong to three categories: high, medium and low epizootic situation intensity of rabies. the projection of differentiated genetic clusters on the epizootic situation showed that cluster ii circulating at left bank of the dnieper in areas with high and medium intensity of the epizootic situation, and the cluster i – at the right bank of the dnieper, mainly in the areas with low intensity of the epizootic situation. that’s why our interest was in the degree of protection of rabies vaccines against street rabies virus isolates belonging to these two genetic clusters. the commercial vaccines made with rabies virus vaccine strains sad (street-alabama-dufferin) and wistar pm/wi were chosen to evaluate this parameter. after the mathematical calculations of effective dose and the analysis of the data the less effective protection of rabies vaccines (at 29–30 %) against street rabies virus isolates belonging to cluster ii in comparison with isolates belonging to cluster i irrespective to the strain vaccine is made was shown. conclusions the data will be used for the effective planning of specific prophylaxis of rabies in ukraine based on differentiated approach to distribution of rabies vaccines in according to region and their activity. keywords rabies vaccine; vaccine activity; street rabies virus isolates; genetic variants of rabies virus *mykola ivanov e-mail: ivanovny@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e154, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts the black canyon forecast station: experiences and lessons learned james m. wilson*1, 2, bonnie koehler3, kathleen sramek2 and treve henwood2 1black canyon forecast station, delta, co, usa; 2delta county memorial hospital, delta, co, usa; 3delta county health and human services, delta, co, usa objective to evaluate the sociological effect on indigenous biological event signature recognition and community resilience due to the operational activities of an infectious disease forecast station. introduction the nation’s first operational infectious disease forecast station, modeled after warning protocols developed in the meteorology community, was activated in 2011. the approach was originally pioneered in haiti following the 2010 earthquake. methods we assembled global event signature and forecast libraries that reflected locally diagnosed infectious disease activity and infrastructure impact in a rural community from a public health, veterinary, and human clinical medicine perspective. the deployment site is home to a variety of infectious disease including hantavirus, plague, tularemia, and west nile in the context of high wildlife-livestockhuman interfacing. information derived from the issuance of forecasts coupled to situational awareness was shared with the public, local officials, public health officers, veterinarians, healthcare providers, and patients through various social media methods. results provision of 30-60-90 day forecasts for routine and non-routine endemic infectious disease activity and impact facilitated better coordination of public health messaging and daily conversation with patients in the inpatient and outpatient settings. the signature of an unusual, infrastructure-disruptive outbreak of metapneumovirus and respiratory syncytial virus was recognized and communicated with enough time to activate effective clinical mitigation protocols. cost estimates demonstrated financial benefit at a local level to anticipating surges of infectious disease activity with enough time to mitigate patient demand. community-wide engagement with infectious disease forecasts and live event advisories included the promotion of proactive infection control and public health surveillance and response, healthcare provider recognition of non-routine infectious disease, clinical sampling and diagnostic testing protocols, clinician and patient education, and synchronization of proactive disease reporting both in the routine daily clinical setting and in times of crisis. collateral benefit of consistent messaging delivered to the public by the participating entities was noted. community awareness of the repertoire of indigenous infectious disease activity was expanded beyond the official public health notification list. neither issuance of infectious disease forecasts nor advisories issued during crises triggered an influx of anxious well phone calls or visits to the medical system that was deemed operationally relevant. conclusions activation of a local infectious disease forecast station modeled after a local weather station promotes routine communication of a broader array of infectious disease activity than that monitored by public health; facilitates proactive, cost effective healthcare; and enabled recognition of unusual, disruptive infectious activity with enough time to enable mitigation of clinical, infrastructure, and financial impact to the community. routine communication of comprehensive infectious disease forecast and situational awareness information promotes community adaptive fitness to a wide variety of infectious hazards. the results suggest it is possible to transform the traditional public health model of data collection and analysis to one of transparent and open data availability to support innovative reduction in morbidity and mortality. keywords biosurveillance; forecast; meteorology acknowledgments the authors would like to acknowledge the tremendous contributions of the staff of ascel bio llc for the design and management of the black canyon forecast station; the personal contributions of mr. michael smith regarding meteorological warning operations; delta county memorial hospital: betty kahrs, janet moore, jason cleckler, bev carlson, randall koehn, johanna roeber, and tom mingen; david van metre of colorado state university and delta county colorado state university agriculture extension agent robbie b. lavalley; and colorado department of agriculture field veterinarian, dan love dvm. *james m. wilson e-mail: jwilson@ascelbio.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e27, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a system for surveillance directly from the emr richard f. davies*1, jason morin1, ramanjot s. bhatia1 and lambertus de bruijn2 1university of ottawa heart institute, ottawa, on, canada; 2national research council canada, ottawa, on, canada objective our objective was to conduct surveillance of nosocomial infections directly from multiple emr data streams in a large multi-location canadian health care facility. the system developed automatically triggers bed-day-level-location-aware reports and detects and tracks the incidents of nosocomial infections in hospital by ward. introduction hospital acquired infections are a major cause of morbidity, mortality and increased resource utilization. cdc estimates that in the us alone, over 2 million patients are affected by nosocomial infections costing approximately $34.7 billion to $45 billion annually (1). the existing process of detection and reporting relies on time consuming manual processing of records and generation of alerts based on disparate definitions that are not comparable across institutions or even physicians. methods a multi-stakeholder team consisting of experts from medicine, infection control, epidemiology, privacy, computing, artificial intelligence, data fusion and public health conducted a proof of concept from four complete years of admission records of all patients at the university of ottawa heart institute . figure 1 lists the data elements investigated. our system uses an open source enterprise bus ‘mirth connect’ to receive and store data in hl7 format. the processing of information is handled by individual components and alerts are pushed back to respective locations.the free text components were classified using natural language processing. negation detection was performed using negex (2). data-fusion algorithms were used to merge information to make it meaningful and allow complex syndrome definitions to be mapped onto the data. results the system monitors: ventilator associated pneumonia (vap), central line infections (cli), methicillin resistant staph aureus (mrsa), clostridium difficile (c. diff) and vancomycin resistant enterococcus (vre). 21452 hospital admissions occurred in 17670 unique patients over four years. there were 41720 cxrs performed in total, of which 10546 were classified as having an infiltrate. 4575 admissions were associated with at least one cxr showing an infiltrate, 2266 of which were hospital-acquired. hospital acquired infiltrates were associated with an increased hospital mortality (6.3% vs 2.6%)* and length of stay (19.5 days vs 6.5 days)*. 253 patients had at least one positive blood culture. this was also associated with an increased hospital mortality (23,3% vs. 2.8%)* and length of stay (10.8 vs 40.9 days)*. (* all p values < 0.00001) conclusions this proof of concept system demonstrates the capability of monitoring and analyzing multiple available data streams to automatically detect and track infections without the need for manual data capture and entry. it acquires directly from the emr data to identify and classify health care events, which can be used to improve health outcomes and costs. the standardization of definitions used for detection will allow for generalization across institutions. keywords electronic health records; surveillance; pneumonia; hospital acquired infections acknowledgments this work was supported by defence research and development canada centre for security science and the chemical, biological, radiological/nuclear, and explosives research and technology initiative (crti) under project crti 06-0234ta and the following participatory and advisory partners. references 1. report on cdc website (http://www.cdc.gov/hai/pdfs/hai/scott_costpaper.pdf) accessed: 10th september, 2012. 2. chapman, w. et. al. 2001. evaluation of negation phrases in narrative clinical reports. proc amia symposium, 105-114. *richard f. davies e-mail: rfdavies@ottawaheart.ca online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e29, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts the surveillance window – contextualizing data streams kirsten mccabe*, lauren castro, mac brown, william daniel, eric nick generous, kristen margevicius and alina deshpande los alamos national laboratory, los alamos, nm, usa objective the goal of this project is the evaluation of data stream utility in integrated, global disease surveillance. this effort is part of a larger project with the goal of developing tools to provide decision-makers with timely information to predict, prepare for, and mitigate the spread of disease. introduction los alamos national laboratory has been funded by the defense threat reduction agency to determine the relevance of data streams for an integrated global biosurveillance system. we used a novel method of evaluating the effectiveness of data streams called the “surveillance window”. the concept of the surveillance window is defined as the brief period of time when information gathered can be used to assist decision makers in effectively responding to an impending outbreak. we used a stepwise approach to defining disease specific surveillance windows; 1. timeline generation through historical perspectives and epidemiological simulations. 2. identifying the surveillance windows between changes in “epidemiological state” of an outbreak. 3. data streams that are used or could have been used due to their availability during the generated timeline are identified. if these data streams fall within a surveillance window, and provide both actionable and non-actionable information, they are deemed to have utility. methods figure 1 shows the overall approach to using this method for evaluating data stream types. our first step was identifying a list of priority diseases to build surveillance windows for and our primary sources were our sme panel, cdc priorities, as well as dod priorities. we also conducted a literature review to support our selection of diseases. we ensured that there was representation of human, animal and plant diseases and there was enough data available for selected outbreaks to facilitate evaluation of all data stream types identified. we then selected representative outbreaks for diseases to generate a timeline for defining surveillance windows. surveillance windows were then defined (based on four specific biosurveillance goals developed by lanl) and information for applicable data streams was collected for the duration of the outbreak. a data stream was deemed useful if it was determined to be available within the defined surveillance window. in addition, evaluation of the ideal use case of the data streams was performed. in essence, if used more effectively could this data stream provide greater support to understanding, detection, warning or management of disease outbreaks or event situations? results results presented in this abstract are from retrospective analyses of historical outbreaks selected as being representative of fmd, ebola, influenza and e.coli. graphs indicating case counts and geographical spread were combined and a timeline was created to determine the length of time between changes in “epidemiological state” that defined various surveillance windows. this timeline was then populated with durations when data streams were used during the outbreak. results showed varying surveillance windows times are dependent on disease characteristics. in turn, epidemiology of the disease affected the occurrence of data streams on the timeline. conclusions surveillance window based evaluation of data streams during disease outbreaks helped identify data streams that are of significance for developing an effective biosurveillance system. some data streams were identified to have high utility for early detection and early warning regardless of disease, while others were more disease and operations specific. this work also identified data streams currently not in use that could be exploited for faster outbreak detection. key useful data streams that are underlying to all disease categories and thus important for integration into global biosurveillance programs will be presented here. figure 1: overall approach to surveillance window based evaluation keywords surveilliance windows; data streams; biosurveilliance acknowledgments this project is supported by the chemical and biological technologies directorate joint science and technology office (jsto), defense threat reduction agency (dtra). *kirsten mccabe e-mail: kjmccab@lanl.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e113, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts objective to document the current evidence base for the use of electronic health record (ehr) data for syndromic surveillance using emergency department, urgent care clinic, hospital inpatient, and ambulatory clinical care data. introduction historically, syndromic surveillance has primarily involved the use of near real-time data sent from hospital emergency department (eds) and urgent care (uc) clinics to public health agencies. the use of data from inpatient and ambulatory settings is now gaining interest and support throughout the united states, largely as a result of the stage 2 and 3 meaningful use regulations [1]. questions regarding the feasibility and utility of applying a syndromic approach to these data sources are hampering the development of systems to collect, analyze, and share this potentially valuable information. solidifying the evidence base and communicating the results to the public health surveillance community may help to initiate and build support for using these data to advance surveillance functions. methods we conducted a literature search in the published and grey literature that scanned for relevant articles in the google scholar, pub med, and ebsco information services databases. search terms included: “inpatient/ambulatory electronic health record”; “ambulatory/inpatient/hospital/outpatient/chronic disease syndromic surveillance”; and “ehr syndromic surveillance”. information gleaned from each article included data use, data elements extracted, and data quality indicators. in addition, several stakeholders who provided input on the september 2012 isds recommendations [2] also provided articles that were incorporated into the literature review. isds also invited speakers from existing inpatient and ambulatory syndromic surveillance systems to give webinar presentations on how they are using data from these novel sources. results the number of public health agencies (phas) routinely receiving ambulatory and inpatient syndromic surveillance data is substantially smaller than the number receiving ed and uc data. some health departments, private medical organizations (including hmos), and researchers are conducting syndromic surveillance and related research with health data captured in these clinical settings [2]. in inpatient settings, many of the necessary infrastructure and analytic tools are already in place. syndromic surveillance with inpatient data has been used for a range of innovative uses, from monitoring trends in myocardial infarction in association with risk factors for cardiovascular disease [3] to tracking changes in incident-related hospitalizations following the 2011 joplin, missouri tornado [3]. in contrast, ambulatory systems face a need for new infrastructure, as well as pose a data volume challenge. the existing systems vary in how they address data volume and what types of encounters they capture. ambulatory data has been used for a variety of uses, from monitoring gastrointestinal infectious disease [3], to monitoring behavioral health trends in a population, while protecting personal identities [4]. conclusions the existing syndromic surveillance systems and substantial research in the area indicate an interest in the public health community in using hospital inpatient and ambulatory clinical care data in new and innovative ways. however, before inpatient and ambulatory syndromic surveillance systems can be effectively utilized on a large scale, the gaps in knowledge and the barriers to system development must be addressed. though the potential use cases are well documented, the generalizability to other settings requires additional research, workforce development, and investment. keywords syndromic surveillance; ehr; meaningful use acknowledgments we thank the isds meaningful use workgroup for their assistance with the literature review, and all the presenters in the isds meaningful use webinar series (http://www.syndromic.org/webinars/meaningfuluse). work supported by cdc through isds contract with task force for global health. references 1. health information technology for economic and clinical health (hitech) act. title xiii of division a and title iv of division b of the american recovery and reinvestment act of 2009 2009; pub. l. no. 111-5. 2. isds. electronic syndromic surveillance using hospital inpatient and ambulatory clinical care electronic health record data: recommendations from the isds meaningful use workgroup. 2012. www.syndromic.org 3. various presenters. isds meaningful use webinar series: 3/13/21/2012. http://www.syndromic.org/webinars/meaningfuluse 4. pavlin ja, murdock p, elbert e, milliken c, hakre s. conducting population behavioral health surveillance by using automated diagnostic and pharmacy data systems. mmwr 2004;53 (supp.):166-172. *rebecca zwickl e-mail: bzwickl@syndromic.org utility of syndromic surveillance using novel clinical data sources rebecca zwickl*, charles ishikawa and laura c. streichert isds, brighton, ma, usa online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e33, 2013 electronic health in ghana: current status and future prospects 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi electronic health in ghana: current status and future prospects ebenezer afarikumah1 1. open university malaysia/accra institute of technology, accra abstract the health-care system in ghana is similar to those in other developing countries and access to health services for remote communities is extremely limited. in july, 2010, the government of ghana launched the national e health strategy. a number of international organizations have initiated various pilot projects, including disseminating and collecting data, education initiatives and telemedicine. in addition, several institutions and organizations are dedicated to the promotion of e-health and a range of web-based health consultancy services have begun. the main objective of this study is to provide an overview of ehealth activities in ghana. it was a daunting task, not least because of the need to gather information on ehealth projects and initiatives in ghana, as there is no existing repository of such information. through literature search in africa journals online, hinari, medline, google.com, journal of telemedicine and ehealth, journal of telemedicine and telecare, journal of medical internet research and interaction with ehealth experts, followed up with some of the authors' for directions to other projects, and following the references in some articles. a total of twenty-two (22) pilot projects have been identified in ghana. mobile devices in use range from pdas to simple phones and smart phones. the key findings of this research are that there are about 22 ehealth project at various stages of implementation in ghana. some of these projects have wind up and others are still being implemented. mobile devices in use range from pdas to simple mobile phones and smart phones. most of the projects have been donor initiated. data collection started in march 2010 to june 2013. although ehealth seems to have a limited role in ghana at present, there is growing interest in the opportunities it may offer in terms of improving the delivery and access to services, especially in remote locations. recommendations for further research are provided. keywords: ehealth, health, ghana, developing countries, information and communications technology corresponding author. afari.telemedicine@yahool.com doi: 10.5210/ojphi.v5i3.4847 copyright ©2014 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health info rmatics. readers may copy articles without permission of the copyright owner(s), as long a s the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. introduction reliable information and effective communication are crucial elements in individual health institutions, disease monitoring and prevention, public health systems, and health care generally. icts, therefore, can in many ways be vital tools in combating disease, promoting individual health and making health systems more effective and efficient. they can be particularly powerful in monitoring the outbreak and spread of disease, disseminating health information (including information about health-promoting and diseasepreventing individual behaviour), and providing training, information and long-distance http://ojphi.org/ electronic health in ghana: current status and future prospects 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi support to health care practitioners. a particular challenge for developing countries is ensuring that icts are effectively mobilized to improve health outcomes and combat disease among the poorest and most remote populations. this is an area where the potential for effective use of the full range of icts (including radio and television) is particularly great. in july, 2010, the government of ghana launched the national e health strategy. the key strategies under the national e-health strategy; streamlining the regulatory framework for health data and information management, building sector capacity for wider application of ehealth solutions in the health sector, increasing access and bridging equity gap in the health sector through the use of information and communication technology, and towards a paperless records and reporting system. ehealth is the term more commonly used in relation to ict deployments in health care. there have been several attempts to define ehealth [1-3] there is still no universal agreement on the precise meaning of this term. according to [4], ehealth is widely used by many individuals, academic institutions, professional bodies and funding organisations. it has become an accepted neologism despite the lack of an agreed-upon clear or precise definition. communication among the many individuals and organisations that use the term could be improved by comprehensive data about the range of meanings encompassed by the term (ibid). fifty –one (51) unique definitions that we retrieved showed a wide range of themes, but no clear consensus about the meaning of the term ehealth. in addition, two universal themes (health and technology) and six less general (commerce, activities, stakeholders, outcomes, place, and perspectives) were identified. the widespread use of the term ehealth suggests that it is an important concept, and that there is a tacit understanding of its meaning (ibid). however, thinks that any definition of ehealth should encompass the full spectrum of icts whilst appreciating the context of use and the value they bring to society [5]. one definition which they identified as taking into consideration the various facets is the one proposed by [6], who defined ehealth as: ‘’...an emerging field of medical informatics, referring to the organisation and delivery of health services and information using the internet and related technologies. in a broader sense, the term characterises not only a technical development, but also a new way of working, an attitude, and a commitment for networked, global thinking, to improve healthcare locally, regionally and worldwide by using information and communications technology. [6]’’ ehealth programs according to [7] offer the potential for enhanced reach, including traditionally underserved populations, at relatively low cost; scalability; time efficiency; and the capacity to provide tailoring and customisation for individual patients and consumers. despite these potential benefits, there are barriers to the full implementation of ehealth solutions, and the limitations of access, health and technology literacy, and quality measures must be addressed [8,9]. it was concluded by [5] saying that “ehealth interventions have considerable potential to transform the health sector, hopefully better. as with many intervention, however, the risk of harm exists, so policy makers, commissioners, clinicians, and patients alike need to remain aware of this possibility”. it was suggested earlier by [10] that if we are to maximise the benefits associated with ehealth interventions whilst minimising risks, we must be able simultaneously to evaluate ehealth interventions while they are being designed, developed, and deployed. solutions which are provided through http://ojphi.org/ electronic health in ghana: current status and future prospects 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi ehealth initiatives within hospitals has been identified by [11] as hospital information systems (his), telemedicine services, electronic health records and internet services. methods the following is not a systematic review of ehealth in ghana, but rather an attempt to gather a diversity of perspectives on the topic from a variety of sources. various papers were identified on these topic by searching through medline, google scholar, journal of health informatics for instances of “ehealth”, “telehealth”, “telemedicine”, “store and forward”, and “teleconsultation + ghana” to name a few. moreover, references were solicited from a variety of experts in the field, many of whom were responsible for building and deploying their own systems. interactions with ehealth experts [12-14]. in addition, follow-up with some of the authors' for directions to other projects. data collection started in march 2010 to june 2011. papers were selected once they discuss an ehealth project in ghana. results using the above criteria and personal contacts of researcher, 22 projects were identified. these projects are: i. sene pda the aim of the project is to use information technology to improve service delivery at the lowest level of service delivery – community-based health planning and services (chps) zones. it is one of the pioneer mobile health projects in ghana. objecti ves of the project are: to use appropriate technology to generate more accurate reports that can be used to make decisions by the community health officers (cho) and the district health managers; to use current technology to reduce the time cho’s spent to generate monthly report on services; improve the follow up of children/mothers registered for services and reduce the dropout rate for immunization and safe motherhood services ii. mobile technology for community health (motech) in ghana the project aims to determine how to use mobile phones to increase the quantity and quality of prenatal and neonatal care in rural ghana, with a goal of improving health outcomes for mothers and their newborns. iii. millennium villages and mobile telemedicine millennium village project is a new approach for fighting extreme poverty. the concept is to target the "poorest of the poor, village by village throughout africa, in partnership with government and other committed stakeholders, providing affordable and science-based solutions to help people lift themselves out of extreme poverty.” iv. pan african enetwork the basic objective of the project is to assist africa in capacity building by way of imparting quality education to 10,000 students in africa over a 5 -year period in various disciplines from some of the best indian universities/educational institutions. besides, this would provide tele-medicine services by way of on line medical consultation to the medical practitioners at the patient end location in africa by indian medical specialists in various disciplines/specialties selected by african union for its member states http://ojphi.org/ electronic health in ghana: current status and future prospects 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi v. onetouch medicareline (ml) • ml phase 1 calls for free phone calls and text messages; • the planned ml phase 2 calls for mms and data reports over sms, and ml • phase 3 calls for free smartphones, reference tools, and custom applications. • 1700 of 2000 enrolled • 2 million calls made • ghana medical association & onetouch telecom vi. ghana consultation network this is a web‐based interface consultation network. it has a network of asynchronous servers hosted at each hospital and integrated with the referral system. it has on board 125 doctors in 6 countries. the project was supported by ghana physicians foundation & ministry of health. other projects associated with this project are the technology infrastructure for emerging regions (tier) and remote asynchronous communication for health care (reach) project vii. moorfields /korle bu eye centre moorfields eye hospital is using the internet to share the specialist knowledge and advice of its consultant eye specialists with hospitals in the developing world. as part of a new project, run in partnership with international telecommunications group, cable & wireless, eye specialists in south africa, tanzania, gambia and ghana will be able to access a dedicated internet site set up by moorfields eye hospital nhs trust viii. mobile teledermatology in ghana mobile teledermatology ‘involves the use of mobile telecommunication technologies allowing easy submission of dermatologic cases without the use of physical internet connectivity’. patients were randomly selected from three outpatient clinics in accra and kumasi ghana. patients underwent physical consultation by an onsite dermatologist. these patients also went through clickdoc data collection and image capture using a samsung u900 soul mobile phone. remote ghanaian dermatologists connected to the patient database using a web-based interface (africa.telederm.org) from the phone in a remote location and viewed cases. for each case, the remote specialists made their own diagnosis on the basis of the patient data and images. ix. pdas in africasatellife‟s experience the goal of the satellife pda project was to demonstrate the viability of handheld computers -also called personal digital assistants or pdas -for addressing the digital divide among health professionals working in africa. in december 2001 satellife’s worked with the american red cross to conduct a pilot that tested the efficacy of pdas for measles field surveys in ghana. thirty ghanaian red cross volunteers, trained over a two -day period, had no trouble with the technology, though some of them had never before used a computer. they were able to complete over 2,400 surveys in just three days, where the traditional paper and pen survey method generally yielded about 200 finished surveys. survey data was turned in at noon on the last day of the pilot; analysis was completed promptly after the data was hot synched into a computer; and a complete report wa s delivered to the ghanaian ministry of health by 5pm. the entire pilot was completed in less than a week, and the speed and ease of gathering this epidemiological data was unprecedented. community volunteers using pdas http://ojphi.org/ electronic health in ghana: current status and future prospects 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi to collect data as part of measles vaccination program in ghana. the project yielded compelling evidence of the value of pdas for data collection and reporting x. disease control/who the who–ghana supported the disease control unit of ghs to develop and pilot a facilitative tool using epi-surveyor. epi-surveyor is a free tool to enable data collection on pdas. there are plans to use the lessons learnt from this pilot and institutionalize the use of pdas for integrated facilitative supervision within the service xi. usaid-deliver project the usaid deliver project in collaboration with the president’s malaria initiative and the national malaria control program has since july 2009 promoted the use of epi -surveyor, mobile phone survey software for collecting data on malaria logistics at the service points every quarter. xii. early warning systemsfocus region project the usaid sponsored project which is working in gar, wr and cr is piloting a logistics management system using mobile phones in six districts in the target regions. the system will facilitate data collection from sdps over sms through facility workers‟ personal mobile phones. the smss will then be sent to a toll-free short code registered with each mobile network in ghana. xiii. sms for life logistic management this project that is yet to be implemented. it is similar to usaid deliver project. it will be implemented as a pilot project in six districts in three regions (ba, ue, gar). xiv. mimcom.net project (http://www.nlm.nih.gov/mimcom/background.html) the national library of medicine chairs the communications working group of the multilateral initiative on malaria (mim), which began in 1997. the objective is to support african scientists and malaria researchers in their ability to connect with one another and sources of information through full access to the internet and the resources of the world wide web, as well as create new collaborations and partnerships. the initial meeting of the mim cwg was held in january 1998 at the nlm/nih in bethesda, maryland. in attendance were malaria research scientists, health information professionals, telecommunications experts and representatives of the major mim funding agencies. in keeping with the underlying goal of supporting a broad spectrum of basic and operational malaria research needs, the researchers requested communications and connectivity capabilities sufficient to provide, at a minimum: robust and reliable e-mail, links to other research sites, access to full text journal articles, database searching, exchange of large files and mapping data, and timely access to electronic information resources worldwide. in july 1999, redwing satellite solutions ltd. (based in the uk) and nlm’s technical consultant mark bennett successfully installed very small aperture terminal (vsat) ground stations at two malaria research sites in kenya, at kisian (cdc funded) and kilifi (wellcome trust funded). the 64kbs dedicated bandwidth purchased was shared by the two sites. these two sites join the malaria research and training center in mali which has full http://ojphi.org/ electronic health in ghana: current status and future prospects 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi internet access via microwave technology, funded by niaid and made operational in june 1998. the nlm team brought on two further sites in december 1999, in ghana in legon near accra (the noguchi memorial institute for medical research) and in navrongo (navrongo health research centre). the ghanaian sites, engaged in malaria vaccine testing, are funded jointly by niaid/nih, the naval institute of medical research, and usaid. when these sites came on line, the overall bandwidth increased to 128kbs and monthly charges were reduced since more sites were sharing the bandwidth. xv. trinet project (http://www.sysmod.com/trinet.htm) this is a project initiated by the informatics development institute (idi). their mission is to provide cost-effective communications for remote regions of developing countries. in 1999, the idi secured european commission backing for a communications network project, entitled trinet, targeted at developing countries in africa. partners were located in ghana, uganda, zambia and zimbabwe, and use a low-earth-orbiting satellite (leosat) for storeand-forward email communications suing amateur packet radio technology, and internet email gateways in developed countries. xvi. mpedigree (http://en.wikipedia.org/wiki/mpedigree) mpedigree refers both to a mobile telephony shortcode platform that interconnects gsm mobile networks in the west african republic of ghana to a central registry wherein pedigree information of product brands belonging to participant manufacturers are stored, as well as the organisation that has emerged in the country to manage and promote this registry to organisations and firms in the health sector of ghana and africa. the latter is named the mpedigree network. in november 2008, the nigerian national agency for drug administration & control (nafdac) reported to an industry publication that its technical committee was evaluating the security credentials of the mpedigree system for a possible roll-out in that country. nafdac and the nigerian pharmaceutical companies formed a consortium in june 2009 to roll the service out for all medicines in nigeria, though this has not happened as at end of 2010. xvii. ehealth initiative this is an electronic health delivery system, launched to enable doctors reach their patients online and bring health care to the door steps of the citizenry. it has a remote doctor/patient interface, which allows a patient to see a doctor without leaving his home or office. this does not seek to prevent patients from visiting hospital but to augment existing health care delivery services. in order to assess the product one has to go online to book an appointment with a doctor on www.ehealthghana.com after which an appointment coordinator will assign doctors to patient depending on the ailment. xviii. vodaphone healthline project (http://www.ghanaweb.com/ghanahomepage/health/artikel.php?id=274377) telecommunications giant, vodafone ghana, launched a health oriented initiative dubbed “healthline”, which aims at educating and informing millions of ghanaians about pertinent health issues. the project, which takes the form of a television and radio show, embarked on a research to solicit basic health questions from ghanaians which are to be answered by medical doctors. according to vodafone ghana, the project will ultimately educate the public and demystify health related issues and practices. it also has the healthline 255, the first medical phone service in ghana powered by vodafone. healthline 255 guarantees accurate medical advice and provides expert medical advice and information to people in need of http://ojphi.org/ electronic health in ghana: current status and future prospects 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi quality health care from the convenience of their phones and has succeeded in revolutionalising access to health information and advice for ghanaians as it provides important information that would help ghanaians make the best health decisions. the healthline call centre is an extension of vodafone ghana’s award winning television programme, healthline which recently won the chartered institute of marketing ghana award for the second year in a row as the ‘best television programme of the year. xix. mahiri mobile (http://www.telmedx.com/ghana-rural-medicine.html) mahiri mobile services of accra has outfitted nurses in rural villages with wireless tablets that deliver high quality, live medical-grade video™ back to the doctors in tamale and nsawam for medical advice. a wide variety of illnesses and medical conditions are being treated that would otherwise not be cared for, ranging from skin disorders and infections to neurological conditions to maternity and pre-natal care. patients are seen at home, in remote clinics, in schools or in community gatherings by traveling nurses trained to use the new technology. this mobile video platform was developed by telmedx of san diego, california, and it allows a doctor on a web browser to examine patients over the high-resolution cameras of mobile phones and tablets for live, realtime consultations. doctors can also take high-resolution photos of patient conditions from a web browser by remotely controlling the back cameras of wireless phones and tablets. the live video and still photos appear side-by-side on a computer screen, and the photos can easily be saved into medical records by the doctors. systems were also identified and these are: 1. ghs ihost http://directbusinesssolution.org/ihost 2. health administration management system (hams) www.infotechsystemsonline.com 3. district health information system (dhis) 4. health information management system (hims) 5. hospital administration management systems discussions and conclusion this paper sought to present an overview of ehealth projects in ghana. ict offer huge opportunities that should be shared with the neediest persons. however, the temptation is to transfer technology without any considerations for local needs and obstacles specific to the place concerned. this will be a great mistake, leading to a waste of money, whatever it comes from private fund or, maybe worse, from cooperation budget. a critical mass of professional and community users of icts in health has not yet been reached in developing countries. many of the approaches being used are still at a relatively new stage of implementation, with insufficient studies to establish their relevance, applicability or cost effectiveness [15]. this makes it difficult for governments in developing countries to determine their investment priorities [15]. however, there are a number of pilot projects that have demonstrated improvement, such as a 50 percent reduction in mortality or 25 -50 percent increases in productivity within the healthcare system [16]. the key findings of this research are that there are about 22 ehealth project at various stages of implementation in ghana. some of these projects have wind up and others are still being implemented. mobile devices in use range range from pdas to simple mobile phones and smart phones. most of the projects have been donor initiated. further studies should investigate factors responsible for the success or failure of some of the projects. with the passage of the ehealth strategy document by the http://ojphi.org/ electronic health in ghana: current status and future prospects 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e230, 2014 ojphi ministry of health, the ehealth terrain will surely be regulated and investors will be protected. acknowledgements i thank all those who provided input for this research. conflicts of interest none references 1. oh h, rizo c, enkin m, jadad a. (2005). what is ehealth (3): a systematic review of published definitions. j med internet res 2005;7(1):e195% ci) indicates that vermilion county experienced a significant decrease in incidence not matched by its control (see table 2). two other control counties also experienced incidence decreases. the decline in adams county may be explained by the excessive time observed for reporting results. of the 14 cases reported for january, six of them required more than 42 days to be reported to the istd and another 4 required more than 74 days. the decline in sangamon county may be related to the consolidation of the city and county health departments during 2006. costs involved with the project involving both the author and lhds staff, have been collected (data not shown). chlamydia complication rate estimations and their associated costs have been collected from the literature.(5, 22-37) from these data we estimate the number of averted cases needed for a county’s intervention to be cost-effective. estimations are made utilizing a range of progression rates (untreated chlamydia to pid) and lifetime costs of pid taken from the literature (table 3). ce for most counties, and most progression rates and costs, may be attained with an incidence decrease of <2%. the specific analysis for vermilion county (table 4) indicates that the intervention produced a net societal benefit in the range of $2,002-$56,061. development and evaluation of gis-based chlamydia trachomatis intervention policy in illinois 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.1, no. 1, 2009 table 2. comparison of post-intervention and pre-intervention data county/status data cases t-test for equality of means independent samples mean range t df sig. champaign/case macon/control post-intervention 88.3 79-100 -0.233 6 0.823 pre-intervention 90.3 72-105 post-intervention 53.0 51-55 -1.021 6 0.347 pre-intervention 58.0 45-68 mclean/case adams/control post-intervention 40.3 36-46 -1.820 6 0.119 pre-intervention 50.8 3 6-64 post-intervention 9.5 4-14 -3.130 6 0.020 pre-intervention 18.3 15-22 peoria/case jackson/control post-intervention 124.8 115-138 -1.602 6 0.160 pre-intervention 138.5 119-152 post-intervention 35.5 30-39 -0.253 6 0.809 pre-intervention 36.5 32-46 vermilion/case kankakee/control post-intervention 31.5 26-3 9 -2.63 5 6 0.039 pre-intervention 40.5 39-45 post-intervention 43.0 38-45 0.23 1 6 0.825 pre-intervention 42.3 34-46 winnebago/case sangamon/control post-intervention 119.5 92-155 -0.147 6 0.888 pre-intervention 121.5 115-130 post-intervention 67.3 61-82 -5.468 6 0.002 pre-intervention 94.8 92-96 table 3. minimum change required for cost-effectiveness utilizing low-to-high values of disease progression and lifetime cost* county champaign mclean peoria vermilion winnebago intervention costs $1,680 $1,892 $10,564 $1,179 $7,448 2005 total cases 1,133 493 1,292 368 1,522 number of averted cases required for ce 10%; $1,060 20 20 100 20 80 25%; $2,150 4 4 20 4 16 50%; $3,180 2 2 8 2 6 percent decrease from 2005 for ce 10%; $1,060 1.8% 4.1% 7.7% 5.4% 5.3% 25%; $2,150 <1.0% <1.0% 1.5% 1.1% 1.1% 50%; $3,180 <1.0% <1.0% <1.0% <1.0% <1.0% * minimum averted cases required for ce was determined using the range of values found in the literature for both disease progression in untreated chlamydia infection (10-50%; 25% median) and lifetime cost ($1,060-$3,180; $2,150 median). table 3 shows the minimum change required for cost-effectiveness utilizing low-to-high values of disease progression and lifetime cost, while table 4 presents the cost-effectiveness of vermilion county interventions table 4. cost-effectiveness of vermilion county intervention development and evaluation of gis-based chlamydia trachomatis intervention policy in illinois 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.1, no. 1, 2009 cases ct averted progresion to pid cases pid averted average cost of pid savings intervention cost net societal benefit/loss 36 10% 3 $1,060 $3,180 $1,179 +$2,001 50% 18 $3,180 $57,240 $1,179 +$56,061 5. discussion the study has found that systematic modeling and evaluation can assist in the development of a more cost-effective chlamydia intervention strategy. as seen in the logic model of the current policy, intervention development is largely dependent on the local std staff who often lack training and resources to develop interventions and evaluate them for effectiveness. the proposed policy showed where additional state inputs (gis/cb) could assist in intervention development. process evaluation is done to assess intervention implementation. finally, the entire intervention is evaluated for effectiveness and cost-effectiveness. the process of developing the model, testing it in five counties, and performing the evaluation shows that there was a significant effect in at least one county, and that it was cost-effective. most interventions and estimations show ce being achieved with a reduction <2%. utilizing the lowest estimation for progression to pid and highest average lifetime cost has all counties achieving ce at a 7.7% reduction. evaluability models have been in use for more than twenty years. they have been used for such purposes as evaluating work flow in large organizations and describing outpatient care alternatives. the utility of gis to assist in std intervention development has been documented for both syphilis and gonorrhea. gis has also been used to describe the extent of chlamydia in areas ranging in size from military bases to a canadian province. cost-effectiveness analysis is quite well documented in a wide variety of fields. most of the ceas done for chlamydia focus on alternative screening strategies and subsequent costs for different treatments and sequalae. literature searches returned no studies applying program theory development and evaluability assessment to std intervention policies. this study describes the partners, roles, inputs, processes and outcomes for a std policy at the state and local level. we have been able to determine an area where an additional input may be incorporated into a process which results in a more favorable outcome. this systematic approach allows for evaluation at different stages, engages partners who have the authority to act of results and outcomes, and has identified a new policy (state input) which may be both more effective (at reducing local chlamydia incidence) and cost-effective (societal benefit exceeds costs). there are three main limitations of this study. the first was the lack of supplemental funding available to the participants to more aggressively act on the additional state input. all agreed to participate in this project while utilizing existing budgets and resources. as a result, the interventions were generally small in scale, utilized only existing staff with other duties, and lacked community partners and widescale activities. in spite of these limitations, one county had a significant incidence decrease. it is unknown if other counties would have had a decrease with additional resources. a second limitation is its scale. it was tested in only five counties during one short portion of the year. the five test counties were chosen based upon a single large city within their jurisdiction and a high chlamydia rate. it is unknown if performing the study during a different time (e.g. summer), or if measuring incidence for a longer time period post-intervention, would have had different results. it is also not known if providing the same state inputs into more, and more diverse counties (in terms of size, population and location) would have returned similar results. development and evaluation of gis-based chlamydia trachomatis intervention policy in illinois 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.1, no. 1, 2009 finally, the assignment of control counties to participants (cases) is imperfect at best. while vermilion’s decrease was not matched by its assigned control, two other control counties did experience significant decreases. more work will have to be done in examining vermilion county’s intervention, and its subsequent incidence, before a better determination can be made as to its effectiveness. references 1) quinn tc. recent advances in diagnosis of sexually transmitted diseases. sex transm dis. 1994 mar-apr;21(2 suppl):s19-27. 2) centers for disease control and prevention. sexually transmitted disease supplement, chlamydia prevalence monitoring project. atlanta, ga: u.s. department of health and human services, centers for disease control and prevention, october 2004. 3) sexually transmitted diseases section. sexually transmitted diseases in illinois 2003 epidemiologic summary and yearly trends tables for 1993-2003. springfield, il: illinois department of public health, sexually transmitted diseases section, 2003. 4) 4women.gov. frequently asked questions about chlamydia: available at: http://www.4women.gov/faq/stdchlam.pdf. accessed october 15, 2005. 5) rein db, kassler wj, irwin kl, rabiee l. direct medical cost of pelvic inflammatory disease and its sequalae: decreasing, but still substantial. obstet gynecol. 2000 mar;95(3):397-402. http://dx.doi.org/10.1016/s0029-7844(99)00551-7 6) centers for disease control and prevention. policy guidelines for prevention and management of pelvic inflammatory disease (pid). mmwr. 1991 apr;40(rr5):1-25. 7) becker km, glass ge, brathwaite w, zenilman jm. geographic epidemiology of gonorrhea in baltimore, maryland, using a geographic information system. am j epidemiol. 1998 apr 1; 147(7):70916. http://dx.doi.org/10.1093/oxfordjournals.aje.a009513 8) zenilman jm, glass g, sheilds t, jenkins pr, gaydos jc, mckee kt jr. geographic epidemiology of gonorrhea and chlamydia on a large military installation: application of a gis system. sex transm infect. 2002 feb;78(1):40-4. http://dx.doi.org/10.1136/sti.78.1.40 9) elliott lj, blanchard jf, beaudoin cm, green cg, nowicki dl, matusko p, moses s. geographical variations in the epidemiology of bacterial sexually transmitted infections in manitoba, canada. sex transm infect. 2002 apr;78(suppl):i1 39-44. 10) wylie jl, cabral t, jolly am. identification of networks of sexually transmitted infection: a molecular, geographic, and social network analysis. j inf dis. 2005 mar;191 :899-906. http://dx.doi.org/10.1086/427661 11) aral so. behavioral aspects of sexually transmitted diseases: core groups and bridging population (editorial). sex transm dis. 2000 jul;27(6):327-8. http://dx.doi.org/10.1097/00007435-20000700000005 12) rothenberg rb. the geography of gonorrhea. am j epidemiol. 1983;1 17:699-94. 13) michaud jm, ellen j, johnson sm, rompalo a. responding to a community outbreak of syphilis by targeting sex partner meeting location: an example of a risk-space intervention. sex transm dis. 2003 jul;30(7):533-38. http://dx.doi.org/10.1097/00007435-200307000-00001 http://4women.gov/ http://www.4women.gov/faq/stdchlam.pdf development and evaluation of gis-based chlamydia trachomatis intervention policy in illinois 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.1, no. 1, 2009 14) han y, coles fb, muse a, hipp s. assessment of a geographically targeted field intervention on gonorrhea incidence in two new york state counties. sex transm dis. 1999 may;26(5):296-302. 15) wholey, j.s., "evaluability assessment: developing program theory" in bickman, l., (ed.): using program theory in evaluation: new directions for program evaluations, no. 33. san francisco: jossey-bass, 1987, pp. 77-92. 16) association of state and territorial health officers. state public health employee worker shortage report: a civil service recruitment and retention crisis. available at:http://www.astho.org/pubs/workforce-survey-report-2.pdf. accessed september 6, 2005. 17) title 77: public health; chapter 1: department of public health; subchapter h: local health departments; part 615 local health department rules; section 615.300 infectious disease. 18) genc m, mardh pa. a cost-effectiveness analysis of screening and treatment for chlamydia trachomatis infection in asymptomatic women. ann intern med. 1996 jan;124(1):1-7. http://dx.doi.org/10.7326/0003-4819-124-1_part_1-199601010-00001 19) hu d, hook ew, goldie sj. screening of chlamydia trachomatis in women 15 to 29 years of age: a cost-effectiveness analysis. ann intern med. 2004 oct;141(7):501-13. http://dx.doi.org/10.7326/0003-4819-141-7-200410050-00006 20) welte r, postma m, leidl r, kretzschmar m. costs and effects of chlamydial screening: dynamic versus static modeling. sex transm dis. 2005 aug;32(8):47483. http://dx.doi.org/10.1097/01.olq.0000161181.48687.cf 21) mandelblatt js, fryback dg, weinstein mc, et al. assessing the effectiveness of health interventions. in: gold mr, siegel je, russell lb, weinstein mc, eds. cost-effectiveness in health and medicine. new york, ny: oxford university press; 1996. 22) yeh jm, hook ew, goldie sj. a refined estimate of the average lifetime cost of pelvic inflammatory disease. sex transm dis. 2003 may;30(5):369-78. http://dx.doi.org/10.1097/00007435200305000-00001 23) westrom l, eschenbach d. pelvic inflammatory disease. in: holmes kk, mardh pa, sparling pf, et al., eds. sexually transmitted diseases. new york: mcgrawhill, 1999:783-809. 24) blake dr, gaydos ca, quinn tc. cost-effectiveness of screening adolescent males for chlamydia on admission to detention. sex transm dis. 2004 feb;31(2):85-95. http://dx.doi.org/10.1097/01.olq.0000109517.07062.fc 25) petitta a, hart sm, bailey em. economic evaluation of three methods of treating urogenital chlamydial infections in the emergency department. pharmacotherapy. 1999 may;19(5):648-54. http://dx.doi.org/10.1592/phco.19.8.648.31534 26) vanderlaan b, karande v, krohm c, morris r, pratt d, gleicher n. cost considerations with infertility therapy: outcome and cost comparison between health maintenance organization and preferred provider organization care based on physician and facility cost. hum reprod. 1998;13(5):1200-5. http://dx.doi.org/10.1093/humrep/13.5.1200 27) mehta sd, bishai d, howell mr, rothman re, quinn tc, zenilman jm. costeffectiveness of five strategies for gonorrhea and chlamydia control among female and male emergency department patients. sex transm dis. 2002 feb;29(2):83-91. http://dx.doi.org/10.1097/00007435-200202000-00004 http://www.astho.org/pubs/workforce-survey-report-2.pdf development and evaluation of gis-based chlamydia trachomatis intervention policy in illinois 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.1, no. 1, 2009 28) marrazzo jm, celum cl, hillis sd, fine d, delisle s, handsfield hh. performance and cost-effectiveness of selective screening criteria for chlamydia trachomatis infection in women. implications for a national chlamydia control strategy. sex transm dis. 1997 mar;24(3):131-41. http://dx.doi.org/10.1097/00007435-199703000-00003 29) howell mr, gaydos jc, mckee kt, quinn tc, gaydo ca. control of chlamydia trachomatis infections in female army recruits: cost-effective screening and treatment in training cohorts to prevent pelvic inflammatory disease. sex transm dis. 1999 oct;26(9):51926. http://dx.doi.org/10.1097/00007435-199910000-00007 30) de vries r, van bergen jeam, de jong-van den berg ltw, postma mj. systematic screening for chlamydia trachomatis: estimating cost-effectiveness using dynamic modeling and dutch data. value health. 2006 jan-feb;9(1):1-1 1. 31) washington ae, katz p. cost of and payment source for pelvic inflammatory disease. trends and projections, 1983 through 2000. jama. 1991 nov 13;266(1 8):2565-9. 32) van valkengoed igm, postma mj, morre sa, et al. cost effectiveness analysis of a population based screening programme for asymptomatic chlamydia trachomatis infections in women by means of home obtained urine specimens. sex transm infect. 2001;77:276-82. http://dx.doi.org/10.1136/sti.77.4.276 33) van bergen jeam, postma mj, peerbooms pgh, spangenberg ac, tjen-a-tak j, bindels pje. effectiveness and cost-effectiveness of a pharmacy-based screening programme for chlamydia trachomatis in a high-risk health centre population in amsterdam using mailed home-collected urine samples. int j std aids. 2004; 15:797-802. http://dx.doi.org/10.1258/0956462042563765 34) ginocchio rh, veenstra dl, connell fa, marrazzo jm. the clinical and economic consequences of screening young men for genital chlamydia infection. sex transm dis. 2003 feb;30(2):99-106. http://dx.doi.org/10.1097/00007435-200302000-00001 35) welte r, kretzschmar m, leidl r, van den hoek a, jager jc, postma mj. costeffectiveness of screening programs for chlamydia trachomatis: a populationbased dynamic approach. sex transm dis. 2000 oct;27(9):518-29. asd. http://dx.doi.org/10.1097/00007435-200010000-00005 36) postma mj, welte r, van den hoek jar, van doornum gjj, jager hjc, coutinho ra. costeffectiveness of partner pharmacotherapy in screening women for asymptomatic infection with chlamydia trachomatis. value health. 2006 mayjun;4(3):266-75. 37) kraut-becher jr, gift tl, haddix ac, irwin kl, greifinger rb. cost effectiveness of universal screening for chlamydia and gonorrhea in us jails. j urban health. 2004 sep;81(3):453-71. http://dx.doi.org/10.1093/jurban/jth130 development and evaluation of gis-based chlamydia trachomatis intervention policy in illinois 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.1, no. 1, 2009 strengthening ehealth systems to support universal health coverage in sub-saharan africa 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi strengthening ehealth systems to support universal health coverage in sub-saharan africa adebowale ojo1,2*, herman tolentino1, steven s. yoon1 1 division of global hiv and tb, centers for disease control and prevention, atlanta, ga 2 public health informatics fellowship program, division of scientific education and professional development, center for surveillance, epidemiology, and laboratory services, centers for disease control and prevention, atlanta, ga abstract the aim of universal health coverage (uhc) is to ensure that all individuals in a country have access to quality healthcare services and do not suffer financial hardship in using these services. however, progress toward attaining uhc has been slow, particularly in sub-saharan africa. the use of information and communication technologies for healthcare, known as ehealth, can facilitate access to quality healthcare at minimal cost. ehealth systems also provide the information needed to monitor progress toward uhc. however, in most countries, ehealth systems are sometimes non-functional and do not serve programmatic purposes. therefore, it is crucial to implement strategies to strengthen ehealth systems to support uhc. this perspective piece proposes a conceptual framework for strengthening ehealth systems to attain uhc goals and to help guide uhc and ehealth strategy development. keywords: ehealth, universal health coverage, global health, sub-saharan africa abbreviations: dream disease relief through excellent and advanced means ehealth – electronic health emr electronic medical record (emr) his health information system hiv human immunodeficiency virus icts information and communications technologies iom institute of medicine (iom) lmics lowand middle-income countries sdgs sustainable development goals uhc universal health coverage strengthening ehealth systems to support universal health coverage in sub-saharan africa 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi un united nations who world health organization correspondence: aojo@cdc.gov* doi: 10.5210/ojphi.v13i3.11550 copyright ©2021 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. introduction at the 2015 united nations (un) general assembly, member countries agreed upon 17 sustainable development goals (sdgs), including sdg 3.8, with the target of achieving universal health coverage (uhc) by 2030. uhc includes financial risk protection, access to quality essential healthcare services, and access to safe, effective, high-quality, and affordable essential medicines and vaccines for all. since the alma-ata declaration of 1978, the world health organization (who) has promoted health for all, meaning that individuals should have an acceptable level of health that allows for social and economic productivity [1]. who has continued to encourage national governments to achieve uhc [2,3], defined as ensuring “all people receive the quality health services they need without suffering financial hardship” [4]. according to a 2017 who and world bank report on uhc global monitoring [5], progress toward uhc has been considerably slow, particularly in sub-saharan africa. as noted in the report, globally, 50% of people do not have access to essential healthcare, and each year, out-of-pocket healthcare expenses lead to extreme poverty for approximately 100 million people. similarly, the who computes a uhc service coverage index to indicate a country’s progress towards coverage for essential health services and financial protection for their population [6]. the index score is derived using the average of 14 indicators and reported on a scale of 0 to 100, indicating a low to a high level of uhc service coverage. as shown in figure 1, the map of african countries shows that most of the countries have an index score of less than 50. strengthening national healthcare systems is a critical step toward uhc. this includes robust financing structures and processes that spread financial risk across a population and that measures risk protection gaps and outcomes; integrated, people-centered healthcare services; adequate numbers of healthcare workers with the expertise to deliver these services; investments in programs that develop this workforce; good governance; supply chain systems for procuring, tracking, distributing, and delivering quality medicines and other interventions; and wellfunctioning, scalable, and interoperable health and related information systems. aside from improving these services, uhc also focuses on how these components are funded, managed, and delivered. mailto:aojo@cdc.gov* strengthening ehealth systems to support universal health coverage in sub-saharan africa 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi who notes that achieving uhc is difficult without the support of ehealth [7], defined as the “cost-effective and secure use of information and communications technologies (icts) for health and health-related fields, including healthcare services, health surveillance, health literature, and health education, knowledge and research [8].” ehealth can solve or prevent health problems, improve access to healthcare systems and services, and improve health outcomes [9]. in line with uhc objectives, ehealth has the potential to improve access and quality of care, expand coverage, minimize the cost of accessing healthcare, enable connectivity in healthcare systems, and build healthcare capacity [10–12]. via interoperable health information systems (his), ehealth can provide the information needed to ensure accountability and to monitor progress toward uhc goals [13,14]. as such, who member countries have agreed on the importance of ehealth for strengthening healthcare systems and attaining uhc [15]. however, the design, development, and implementation of ehealth systems are not without challenges. for instance, most ehealth systems in lowand middle-income countries (lmics) are not yet scalable and sustainable [16,17]. challenges include policy and governance, financing, the use of standards, and workforce capacity. similarly, the who [7] conducted a global survey on ehealth development and their role in achieving uhc. the report, published in 2016, showed the state of development on different components of ehealth across who member countries. a variable of interest is the availability of a national electronic health record (ehr) system, a possible indicator of the extent of a country’s population covered by ehealth. findings from the survey, as depicted in figure 2, show that only five out of the 33 africa countries surveyed have a national electronic health record (ehr) system. figure 1: uhc service coverage index in africa (data source: who [6]) strengthening ehealth systems to support universal health coverage in sub-saharan africa 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi figure 2: availability of a national electronic health record (ehr) system in africa (data source: who [7]) we argue that strengthening ehealth systems can accelerate progress toward uhc goals. therefore, we propose a conceptual model for strategically strengthening ehealth systems to improve uhc outcomes. we describe potential ehealth interventions that could help attain uhc outcomes; important foundational elements necessary for strengthening ehealth systems; and the proposed conceptual model. ehealth interventions and uhc outcomes in measuring progress toward achieving uhc, it is important to capture healthcare system coverage, including the number of people receiving care and the availability and quality of essential healthcare services. data on household healthcare expenditure and the proportion of household income used for healthcare are also important. who has recognized the role of ehealth in supporting the uhc outcome of ensuring quality healthcare services that cover all persons [9,18]. similarly, in the united states, buntin et al. [19] highlighted the potential contributions of the provisions of the health information technology for economic and clinical health act to achieving the objectives of the affordable care act. for instance, it was noted that the use of health information technology by service providers for individual-level information management could contribute to efforts aimed at quality improvement, cost reduction, and increased access and coverage. in line with the who digital health interventions classification [20], we examined the potential of stakeholder-driven ehealth interventions as a means to attaining uhc outcomes. strengthening ehealth systems to support universal health coverage in sub-saharan africa 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi quality of healthcare services access to quality healthcare services is one of the fundamental tenets of uhc. a publication of the us institute of medicine (iom) noted that although the number of people with access to healthcare services worldwide is increasing, these services are often of poor quality [21]. according to iom, the six key dimensions to measuring the quality of healthcare services are safety, efficiency, person-centeredness, timeliness/accessibility, effectiveness, and equity [21]. interestingly, some of these dimensions are also embedded in the access and coverage and financial risk protection dimensions of uhc, which are discussed below. accurate and timely information is needed to measure quality and contribute to quality improvement efforts. ehealth interventions such as health management information systems and health information repositories provide both individual-level and aggregate data that could facilitate quality improvement at different levels of healthcare [19]. specifically, for measures such as patient safety and efficiency, electronic medical record (emr) systems are used for managing patients’ clinical and laboratory information over time and space. thus, emrs have the potential to improve patient care and safety and also reduce waste associated with duplicate diagnostic tests, leading to efficiency [19]. similarly, studies have shown the potential of telemedicine in improving safety, especially by reducing medication errors and malpractice claims and costs [22,23]. access and coverage tanahashi model and uhc. another key dimension of uhc is that all persons can access necessary healthcare services. drawing from the widely cited tanahashi model of health service coverage [24], five key measures of healthcare access and coverage are availability coverage, accessibility coverage, acceptability coverage, contact coverage, and effective coverage. these measures are represented as cascades of successive levels in which challenges at one level affect the next, thus creating healthcare system performance gaps in quality, coverage, and affordability. mehl and labrique [25] adapted the tanahashi model to uhc and updated these measures to include accountability coverage, availability of commodities and equipment, availability of human resources, continuous coverage, and financial coverage. the updated model also served as the basis of the who recommendations for digital health interventions for healthcare systems [18]. accountability coverage. a fundamental tenet of uhc is the ability to account for all individuals that need access to healthcare services. accountability coverage means being able to quantify the population enrolled in the healthcare system. to achieve this and promote person-centered care, ehealth systems enable countries to monitor an individual’s health across time and place, that is, including birth, key health events, and death. ehealth systems such as emrs, identification registries, civil registration and vital statistics, and health information repositories, can capture data needed to determine accountability coverage. for example, biometric data via fingerprint identification have been used to link community data and hospitals to uniquely identify individuals seeking care in two district hospitals in ghana [26]. accessibility of healthcare facilities, availability of commodities and equipment, and availability of human resources. to achieve the uhc objective of quality healthcare services, healthcare facilities need sufficient qualified and motivated workers and accessible essential commodities strengthening ehealth systems to support universal health coverage in sub-saharan africa 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi and equipment. ehealth systems, such as telemedicine and client communication systems, can be used to remove barriers that may prevent individuals from accessing healthcare services. telemedicine has been used to bring healthcare services to hard-to-reach populations and enhance learning in instances of insufficient expertise [27,28]. for example, the disease relief through excellent and advanced means (dream) program operating in sub-saharan africa [29] has used telemedicine to improve the knowledge of local healthcare workers in treating neurological disorders in patients with hiv. furthermore, human resource information systems have been used to deliver interventions addressing healthcare worker shortages, training, and regulatory concerns in kenya and zambia [30]. logistics management information systems, such as cstock in malawi, have been used for reporting stock data, thereby enhancing supply chain management [31]. contact coverage and continuous coverage. in the context of equity in healthcare service access, contact coverage is the number of individuals who are in contact with the needed service. continuous coverage, on the other hand, is the extent to which those in contact with a needed service can complete the full course of intervention required. barriers such as affordability, negative experiences with a care provider, and social discrimination may affect individuals’ demand for healthcare services, thus affecting coverage. to improve the demand for healthcare services, client communication systems can enhance interaction between clients and providers. emrs and shared health records or health data repositories can ensure continuity of care and allow for longitudinal tracking of patients. for example, studies have shown that the use of text messages for patient education, appointment and medication reminders, and integration of laboratory results with medical records improved maternal retention and antiretroviral therapy adherence among hiv-positive pregnant women [32]. effective coverage. effective coverage refers to the number of individuals in need of healthcare services who receive quality and satisfactory services. sometimes, healthcare providers’ inefficiencies may contribute to patients’ dissatisfaction with healthcare services, thus leading to reduced effective coverage. as noted earlier, telemedicine interventions could serve as a learning and collaboration platform for healthcare providers. furthermore, the use of decision support systems can improve providers’ knowledge of evidence-based best practices and increase their efficiency and effectiveness. for example, in south africa, primary care clinicians use a checklistbased decision support tool for common health conditions [33]. similarly, a study assessing a decision support system for disease surveillance in sierra leone reported that the system aided decision making for operational tasks while also reducing the time spent on data analysis [34]. financial coverage. a key objective of uhc is to ensure that the cost of using healthcare services does not put people at risk for financial hardship. one of the performance measures is the number of individuals protected from poverty due to receiving healthcare services. this implies that there are healthcare financing mechanisms in place to ensure effective and efficient service delivery while minimizing costs to patients. healthcare finance and insurance information systems can deliver interventions that encourage clients to seek healthcare services and providers to perform them. similarly, such systems also facilitate managing health insurance issues such as membership enrollment and verification, and claims management. for example, in kenya, studies have shown how m-tiba (http://m-tiba.co.ke), a mobile health application, helps families save money for future healthcare costs [35]. strengthening ehealth systems to support universal health coverage in sub-saharan africa 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi ehealth foundations most lmics struggling toward uhc also face challenges related to ehealth policy implementation, leadership, funding, infrastructure, and workforce capacity [16,17]. for example, investments and funding required for complex interoperable his design, development, implementation, and use are not readily available and sustainable in the long term. simultaneously, the benefits of large investments in his are often not readily visible in the short term. similarly, gaps in economic evaluation can hinder continued financial investments in ehealth projects [36]. furthermore, countries often lack the informatics workforce capacity needed to design, develop, implement, and effectively use ehealth [10]. finally, most countries lack a national-scale ehealth infrastructure, which hinders interoperability needed for linking disparate his [11]. we adapt the informatics-savvy health department framework [37] to conceptualize what is needed to optimize ehealth systems to help achieve uhc. the informatics-savvy health department framework was developed as a call for health departments to implement measures needed for evolving information needs. an informatics-savvy health department or ministry has “a clear vision, strategy, and governance for information management and use; a workforce skilled in using information and information technologies; and well-designed and effectively used information systems” [37]. thus, the framework is comprised of three main elements: vision and strategy, competent workforce, and well-designed information systems. we add ehealth financing as a distinct element to be considered as part of the ehealth foundations. while one may argue that ehealth financing is already a component of vision and strategy, we posit that financing is a crucial factor to be considered in strengthening ehealth systems, particularly in sub-saharan africa, where lack of funds has often been cited as a major sustainability challenge [38,39]. vision and strategy a vision statement and strategy can help position ehealth to support uhc. this addresses a fundamental and pervasive challenge of ehealth projects that have been unable to reach scale in most countries. key issues such as an existing national ehealth strategy, knowledgeable leadership, sustained funding, and strong information partnerships are important indicators of vision and strategy. a national ehealth strategy helps coordinate ehealth activities in a country and should reflect the country’s ehealth vision, action plan, and monitoring and evaluation plan [40]. ehealth strategies facilitate the development and adoption of standards for interoperability, and the required regulations needed for the ehealth ecosystem to thrive. although some countries have developed an ehealth strategy, there is still scarce evidence of implementation and outcomes. similarly, leadership is fundamental to driving strategy and implementation actions. knowledgeable, decisive, and supportive leaders are crucial to implementing change, establishing and sustaining partnerships, and motivating the workforce toward the realization of a country’s ehealth goals [16,41,42]. considering the diverse stakeholders involved in planning and implementing ehealth projects, it is important to develop strong information partnerships to align the country’s ehealth goals. strengthening ehealth systems to support universal health coverage in sub-saharan africa 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi ehealth financing integral to the successful implementation and sustainability of ehealth interventions is balanced ehealth financing approaches, including short-term and long-term funding, enterprise funding, and programmatic funding from internal and external sources. the implementation of ehealth systems requires significant capital investment at the outset. also, maintenance and sustainability of ehealth systems require continuous funding, which could be justified by quantitative and nonquantitative articulation of benefits—capacities usually scarce in low-resource settings. abu taher et al. [43] revised the tsuji-akematsu model of quantifying ehealth benefits to propose that if the cost of using ehealth system could be quantified for each user, these calculations could be used to indicate a revenue source for financing ehealth systems. for instance, in a system where health is financed through users’ contribution, the cost of using ehealth systems, when known, could also be added to the cost of using healthcare. given potential, systematic, and ehealth-enabled percapita quantification of costs and benefits of ehealth interventions, we posit that healthcare financing models adopted by countries to support uhc could also be applied to financing ehealth. competent workforce studies have shown that the ehealth workforce in sub-saharan africa is insufficient, with some countries even lacking the skills needed to drive ehealth initiatives [41,44]. the ehealth workforce is expected to be able to “discriminate vast amounts of information and extract and synthesize knowledge that is necessary for clinical and population-based decision making” [45]. strategies are needed to motivate the existing workforce to improve their knowledge and skills and to teach these healthcare workers. similarly, strategies that align with ehealth goals are needed to recruit and retain healthcare workers. lastly, training institutions can develop and strengthen academic programs in health information and communications technologies to ensure the continuous availability of a well-trained workforce. well-designed ehealth architecture the importance of a well-designed ehealth architecture cannot be overemphasized. linking disparate information systems is critical for the accountability objective of uhc. a key indicator is an ehealth enterprise architecture that establishes the various data sources required by the country’s healthcare sector and addresses interoperability, data standards, security and confidentiality, and information systems (software, hardware, and infrastructure) issues. this, in addition to plans documented in a national ehealth strategy, can guide a country toward attaining ehealth goals [46]. conceptual model we propose a framework for strengthening ehealth systems to support uhc outcomes and to help guide joint uhc and ehealth strategic planning (figure 3). our conceptual model is a logic model with three main components: ehealth foundations, stakeholder-driven ehealth interventions, and uhc outcomes. ehealth foundations, as adapted from the informatics-savvy health department framework, consist of vision and strategy, competent workforce, well-designed ehealth architecture, and financing. strengthening ehealth systems to support universal health coverage in sub-saharan africa 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi these interrelated foundational elements, as shown in the model, enable the effective design, development, and implementation of ehealth interventions. the second component of the model, stakeholder-driven ehealth interventions, is derived from who’s classification of digital health interventions, which is an effort to create a taxonomy of the digital and mobile technologies used to address healthcare system challenges. these interventions, which we believe should be driven by relevant stakeholders, are broadly classified based on the primary users: clients, healthcare service providers, healthcare system managers, and cross-cutting data services. the model shows the various ehealth interventions that could support the measurement and improvement of uhc indicators. the third component of the model is the uhc outcomes: quality healthcare services, access and coverage, and financial risk protection. the quality dimension of uhc, as shown in the model, is derived from iom’s definition of healthcare quality [22]. the dimensions of access, coverage, and financial risk protection are adapted from the tanahashi model of healthcare service coverage [25] and mehl’s and labrique’s cascading model [26], which prioritizes mhealth strategies for attaining uhc. figure 3: a conceptual strategic framework for leveraging ehealth to support universal health coverage however, for ehealth interventions to deliver expected benefits, especially in sub-saharan africa, vision and strategy, adequate financing, a competent workforce, and a well-designed ehealth architecture are important components that should be considered. although this model was conceptualized for supporting uhc outcomes, it could apply to various disease domains (figure 4). for instance, in the hiv domain, programmatic efforts are aimed at improving the quality of services, access, coverage, and financial risk protection for patients. strengthening ehealth systems to support universal health coverage in sub-saharan africa 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi strengthening ehealth systems could enable the design, development, and implementation of ehealth interventions that support quality hiv care and services, thus reducing new infections and aids-related deaths. similarly, ehealth interventions could lead to better coverage in terms of increased uptake in hiv testing and increased antiretroviral therapy coverage. for example, studies have shown that a common ehealth intervention in the hiv domain is using mobile technologies like text messaging and mobile applications to improve communication between patients and care providers, enhance appointment and medication adherence, improve uptake of testing, and support remote monitoring of patients [47–49]. in the case of financial risk protection, m-tiba helps users save funds for their healthcare expenses. the application provides health insurance functionalities that allow users to receive funds from government, donor agencies, or family members; save funds; and spend saved funds only on medical treatment [35]. strengthening ehealth systems to support universal health coverage in sub-saharan africa 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e17, 2021 ojphi figure 4: the conceptual strategic framework for leveraging ehealth applied to the hiv disease domain strengthening ehealth systems to support universal health coverage in sub-saharan africa 12 ojphi limitations the conceptual framework proposed in this paper is an adaptation of existing models. as such, it should be subjected to further refinements and empirical tests. conclusion we propose a framework for strengthening ehealth systems to support the attainment of a country’s uhc goals and to inform joint uhc and ehealth strategy development. although the role of ehealth in supporting uhc objectives has been recognized, few publications have suggested appropriate strategies that can be used to implement effective ehealth systems. we posit that countries can strategically strengthen their ehealth system for supporting the uhc outcomes of quality healthcare, access, and financial risk protection via ehealth systems based on vision and strategy, adequate financing, a competent workforce, and a well-designed architecture. the proposed framework could aid countries in planning for supporting uhc with ehealth or in evaluating and identifying gaps in ehealth to achieve uhc. the framework can also be applied to other disease domains as part of ongoing efforts to strengthen healthcare systems. further research exploring the direct contribution of ehealth interventions on uhc outcomes is recommended. acknowledgments this publication has been supported by the president’s emergency plan for aids relief (pepfar) through the centers for disease control and prevention (cdc). disclaimer the findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the centers for disease control and prevention (cdc). conflicts of interest: the authors have no conflicts of interest to declare. references 1. world health organization. who called to return to the declaration of alma-ata [internet]. soc. determ. heal. 2015 [cited 2020 mar 4]. p. 1–2. available from: https://www.who.int/social_determinants/tools/multimedia/alma_ata/en/. 2. ghebreyesus ta. all roads lead to universal health coverage. lancet glob heal [internet]. 2017;5:e839–e840. available from: http://linkinghub.elsevier.com/retrieve/pii/s2214109x17302954. 3. bassett mt. 2006. health for all in the 21st century. am j public health. 96, 2089. pubmed https://doi.org/10.2105/ajph.2006.102533 https://pubmed.ncbi.nlm.nih.gov/17077403 https://doi.org/10.2105/ajph.2006.102533 strengthening ehealth systems to support universal health coverage in sub-saharan africa 13 ojphi 4. world health organization. arguing for universal health coverage. world heal. organ. 2013. 5. world health organization. international bank for reconstruction and development, worldbank. tracking universal health coverage: 2017 global monitoring report [internet]. world health organization and international bank for reconstruction and development / the world bank; 2017. available from: http://apps.who.int/iris/bitstream/handle/10665/259817/9789241513555eng.pdf;jsessionid=c29e21005a5692511be2b70bd2d3c941?sequence=1. 6. world health organization. uhc service coverage index (sdg 3.8.1) [internet]. available from: https://www.who.int/data/gho/data/indicators/indicator-details/gho/uhc-index-ofservice-coverage. 7. world health organization. global diffusion of ehealth: making universal health coverage achievable. report of the third global survey on ehealth [internet]. geneva: world health organization; 2016. available from: https://www.who.int/goe/publications/global_diffusion/en/. 8. world health organization. resolution wha 58.28 ehealth. fifty-eighth world heal assem geneva, may 16 –25, 2005 resolut decis annex [internet]. geneva; 2005. p. 121–123. available from: http://www.who.int/healthacademy/news/en/. 9. al-shorbaji n. 2013. the world health assembly resolutions on ehealth: ehealth in support of universal health coverage [internet]. methods inf med. 52, 463-66. http://www.thiemeconnect.de/doi/doi?10.1055/s-0038-1627062. pubmed https://doi.org/10.1055/s-00381627062 10. etienne cf. 2014. ehealth: harnessing technology on the road towards universal health coverage. rev panam salud publica. 35, 320-22. pubmed 11. hussein r. 2015. a review of realizing the universal health coverage (uhc) goals by 2030: part 2what is the role of ehealth and technology? j med syst. •••, 72. pubmed https://doi.org/10.1007/s10916-015-0255-x 12. ojo ai. 2018. mhealth interventions in south africa: a review. sage open. •••, 8. https://doi.org/10.1177/2158244018767223 13. ingun p, streveler d, brown k, et al. the role of information system in achieving universal health coverage [internet]. 2010. available from: http://www.who.int/healthsystems/topics/financing/healthreport/icttbno10.pdf. 14. sarbadhikari sn. 2013. the role of public health informatics in providing universal health coverage. int j med sci public health. 2, 162-63. 15. labrique a, vasudevan l, mehl g, et al. 2018. digital health and health systems of the future. glob health sci pract. 6, s1-4. pubmed https://doi.org/10.9745/ghsp-d-18-00342 https://pubmed.ncbi.nlm.nih.gov/24310395 https://doi.org/10.1055/s-0038-1627062 https://doi.org/10.1055/s-0038-1627062 https://pubmed.ncbi.nlm.nih.gov/25211556 https://pubmed.ncbi.nlm.nih.gov/26044851 https://doi.org/10.1007/s10916-015-0255-x https://doi.org/10.1177/2158244018767223 https://pubmed.ncbi.nlm.nih.gov/30305334 https://doi.org/10.9745/ghsp-d-18-00342 strengthening ehealth systems to support universal health coverage in sub-saharan africa 14 ojphi 16. asamoah-odei e, kebede d, zielinski c, et al. 2011. leveraging ehealth to improve national health systems in the african region. afr health monit. (march), 46-52. 17. omotosho a, ayegba p, emuoyibofarhe j, et al. 2019. current state of ict in healthcare delivery in developing countries. int j online biomed eng. 15, 91. https://doi.org/10.3991/ijoe.v15i08.10294 18. world health organization. who guideline: recommendations on digital interventions for health system strengthening. geneva: world health organization; 2019. 19. buntin mb, jain sh, blumenthal d. 2010. health information technology: laying the infrastructure for national health reform. health aff (millwood). 29, 1214-19. pubmed https://doi.org/10.1377/hlthaff.2010.0503 20. world health organization. classification of digital health interventions v1.0: a shared language to describe the uses of digital technology for health [internet]. geneva; 2018. available from: https://apps.who.int/iris/handle/10665/260480. 21. national academies of sciences, engineering, and medicine. crossing the global quality chasm [internet]. crossing glob. qual. chasm. washington, d.c.: national academies press; 2018. available from: https://doi.org/10.17226/25152. 22. lilly cm, zubrow mt, kempner km, et al. 2014. critical care telemedicine: evolution and state of the art. crit care med. 42, 2429-36. pubmed https://doi.org/10.1097/ccm.0000000000000539 23. dharmar m, kuppermann n, romano ps, et al. 2013. telemedicine consultations and medication errors in rural emergency departments. pediatrics. 132, 1090-97. pubmed https://doi.org/10.1542/peds.2013-1374 24. tanahashi t. 1978. health service coverage and its evaluation [internet]. bull world health organ. 56, 295-303. http://www.ncbi.nlm.nih.gov/pubmed/96953%0ahttp://www.pubmedcentral.nih.gov/arti clerender.fcgi?artid=pmc2395571. pubmed 25. mehl g, labrique a. prioritizing integrated mhealth strategies for universal health coverage. science (80-) [internet]. 2014;345:1284–1287. available from: http://www.sciencemag.org/cgi/doi/10.1126/science.1258926. 26. odei-lartey eo, boateng d, danso s, et al. 2016. the application of a biometric identification technique for linking community and hospital data in rural ghana. glob health action. 9, 17. pubmed https://doi.org/10.3402/gha.v9.29854 27. forcillo j, watkins da, brooks a, et al. 2019. making cardiac surgery feasible in african countries: experience from namibia, uganda, and zambia. j thorac cardiovasc surg. 158, 1384-93. pubmed https://doi.org/10.1016/j.jtcvs.2019.01.054 https://doi.org/10.3991/ijoe.v15i08.10294 https://pubmed.ncbi.nlm.nih.gov/20530358 https://doi.org/10.1377/hlthaff.2010.0503 https://doi.org/10.17226/25152 https://pubmed.ncbi.nlm.nih.gov/25080052 https://doi.org/10.1097/ccm.0000000000000539 https://pubmed.ncbi.nlm.nih.gov/24276844 https://doi.org/10.1542/peds.2013-1374 https://pubmed.ncbi.nlm.nih.gov/96953 https://pubmed.ncbi.nlm.nih.gov/26993473 https://doi.org/10.3402/gha.v9.29854 https://pubmed.ncbi.nlm.nih.gov/30819574 https://doi.org/10.1016/j.jtcvs.2019.01.054 strengthening ehealth systems to support universal health coverage in sub-saharan africa 15 ojphi 28. faye o, bagayoko c, dicko a, et al. 2018. a teledermatology pilot programme for the management of skin diseases in primary health care centres: experiences from a resourcelimited country (mali, west africa). trop med infect dis. 3, 88. pubmed https://doi.org/10.3390/tropicalmed3030088 29. leone m, corsi fm, ferrari f, et al. 2018. teleneurology in sub-saharan africa: experience from a long lasting hiv/aids health program (dream). j neurol sci. 391, 109-11. pubmed https://doi.org/10.1016/j.jns.2018.06.013 30. were v, jere e, lanyo k, et al. 2019. success of a south-south collaboration on human resources information systems (hris) in health: a case of kenya and zambia hris collaboration. hum resour health. 17, 6-11. pubmed https://doi.org/10.1186/s12960-0190342-z 31. shieshia m, noel m, andersson s, et al. 2014. strengthening community health supply chain performance through an integrated approach: using mhealth technology and multilevel teams in malawi. j glob health., 4. pubmed https://doi.org/10.7189/jogh.04.020406 32. john-stewart g. 2018. ehealth and prevention of mother-to-child transmission of hiv. curr hiv/aids rep. 15, 350-57. pubmed https://doi.org/10.1007/s11904-018-0408-x 33. yau m, timmerman v, zwarenstein m, et al. e-pc101: an electronic clinical decision support tool developed in south africa for primary care in low-income and middle-income countries. bmj glob heal [internet]. 2019;3:e001093. available from: http://gh.bmj.com/lookup/doi/10.1136/bmjgh-2018-001093. 34. pore m, arnold al, mugambi p, et al. 2018. a qualitative evaluation of a decision support system for district-level disease surveillance in sierra leone. stud health technol inform. 247, 451-55. pubmed 35. meessen b. the role of digital strategies in financing health care for universal health coverage in lowand middle-income countries. glob heal sci pract [internet]. 2018;6:s29– s40. available from: http://www.ghspjournal.org/lookup/doi/10.9745/ghsp-d-18-00271. 36. bassi j, lau f. 2013. measuring value for money: a scoping review on economic evaluation of health information systems. j am med inform assoc. 20, 792-801. pubmed https://doi.org/10.1136/amiajnl-2012-001422 37. brand b, laventure m, lipshutz ja, et al. 2018. the information imperative for public health: a call to action to become informatics-savvy. j public health manag pract [internet]. 24, 586-89. http://insights.ovid.com/crossref?an=00124784-201811000-00014. pubmed https://doi.org/10.1097/phh.0000000000000892 38. adeloye d, adigun t, misra s, et al. 2017. assessing the coverage of e-health services in sub-saharan africa [internet]. methods inf med. 56, 189-99. http://www.thiemeconnect.de/doi/doi?10.3414/me16-05-0012. pubmed https://doi.org/10.3414/me16-050012 https://pubmed.ncbi.nlm.nih.gov/30274484 https://doi.org/10.3390/tropicalmed3030088 https://pubmed.ncbi.nlm.nih.gov/30103956 https://doi.org/10.1016/j.jns.2018.06.013 https://pubmed.ncbi.nlm.nih.gov/30646916 https://doi.org/10.1186/s12960-019-0342-z https://doi.org/10.1186/s12960-019-0342-z https://pubmed.ncbi.nlm.nih.gov/25520796 https://doi.org/10.7189/jogh.04.020406 https://pubmed.ncbi.nlm.nih.gov/29931467 https://doi.org/10.1007/s11904-018-0408-x https://pubmed.ncbi.nlm.nih.gov/29678001 https://pubmed.ncbi.nlm.nih.gov/23416247 https://doi.org/10.1136/amiajnl-2012-001422 https://pubmed.ncbi.nlm.nih.gov/30273294 https://pubmed.ncbi.nlm.nih.gov/30273294 https://doi.org/10.1097/phh.0000000000000892 https://pubmed.ncbi.nlm.nih.gov/28244548 https://doi.org/10.3414/me16-05-0012 https://doi.org/10.3414/me16-05-0012 strengthening ehealth systems to support universal health coverage in sub-saharan africa 16 ojphi 39. kiberu vm, mars m, scott re. 2017. barriers and opportunities to implementation of sustainable e-health programmes in uganda: a literature review. afr j prim health care fam med. 9, 8. pubmed https://doi.org/10.4102/phcfm.v9i1.1277 40. scott re, mars m. 2013. principles and framework for ehealth strategy development. j med internet res. 15, 1-14. pubmed https://doi.org/10.2196/jmir.2250 41. ojo ai. repositioning health information management practice in nigeria: suggestions for africa. heal inf manag j [internet]. 2018;47:140–144. available from: http://journals.sagepub.com/doi/10.1177/1833358317732008. 42. jones t, stroetmann k, dobrev a, et al. 2011. ehealth for african countries – sustainable strategies. ist-africa. 2011, 1-11. 43. abu taher s, uddin mk, tsuji m. financing ehealth: tsuji–akematsu model revisited. 22nd bienn conf int telecommun soc "beyond boundaries challenges business, policy soc. seoul: international telecommunications society; 2018. 44. ogoe ha, asamani ja, hochheiser h, et al. 2018. assessing ghana’s ehealth workforce: implications for planning and training [internet]. hum resour health. 16, 65. http://ovidsp.ovid.com/ovidweb.cgi?t=js&page=reference&d=emexa&news=n&an= 625217977. pubmed https://doi.org/10.1186/s12960-018-0330-8 45. frenk j, chen l, bhutta za, et al. 2010. health professionals for a new century: transforming education to strengthen health systems in an interdependent world [internet]. lancet. 376, 1923-58. https://linkinghub.elsevier.com/retrieve/pii/s0140673610618545. pubmed https://doi.org/10.1016/s0140-6736(10)61854-5 46. higman s, dwivedi v, nsaghurwe a, et al. 2019. designing interoperable health information systems using enterprise architecture approach in resource-limited countries: a literature review. int j health plann manage. 34, e85-99. pubmed https://doi.org/10.1002/hpm.2634 47. van den berk gel, leoni mc, behrens gmn, et al. 2020. improving hiv-related care through ehealth [internet]. lancet hiv. 7, e8-10. doi:https://doi.org/10.1016/s23523018(19)30348-0. pubmed 48. purnomo j, coote k, mao l, et al. 2018. using ehealth to engage and retain priority populations in the hiv treatment and care cascade in the asia-pacific region: a systematic review of literature. bmc infect dis. 18, 1-16. pubmed https://doi.org/10.1186/s12879-0182972-5 49. henny kd, wilkes al, mcdonald cm, et al. 2018. a rapid review of ehealth interventions addressing the continuum of hiv care (2007–2017). aids behav. 22, 43-63. pubmed https://doi.org/10.1007/s10461-017-1923-2 https://pubmed.ncbi.nlm.nih.gov/28582996 https://doi.org/10.4102/phcfm.v9i1.1277 https://pubmed.ncbi.nlm.nih.gov/23900066 https://doi.org/10.2196/jmir.2250 https://pubmed.ncbi.nlm.nih.gov/30482223 https://doi.org/10.1186/s12960-018-0330-8 https://pubmed.ncbi.nlm.nih.gov/21112623 https://doi.org/10.1016/s0140-6736(10)61854-5 https://pubmed.ncbi.nlm.nih.gov/30182517 https://doi.org/10.1002/hpm.2634 https://doi.org/10.1016/s2352-3018(19)30348-0 https://doi.org/10.1016/s2352-3018(19)30348-0 https://pubmed.ncbi.nlm.nih.gov/31776102 https://pubmed.ncbi.nlm.nih.gov/29454322 https://doi.org/10.1186/s12879-018-2972-5 https://doi.org/10.1186/s12879-018-2972-5 https://pubmed.ncbi.nlm.nih.gov/28983684 https://doi.org/10.1007/s10461-017-1923-2 paper details improving agent based models and validation through data fusion 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 improving agent based models and validation through data fusion marek laskowski, bryan c.p. demianyk, marcia r. friesen, robert d. mcleod and shamir n. mukhi 1 internet innovation centre, university of manitoba 1 the canadian network for public health intelligence (cnphi) 1015 arlington street, winnipeg, mb abstract this work is contextualized in research in modeling and simulation of infection spread within a community or population, with the objective to provide a public health and policy tool in assessing the dynamics of infection spread and the qualitative impacts of public health interventions. this work uses the integration of real data sources into an agent based model (abm) to simulate respiratory infection spread within a small municipality. novelty is derived in that the data sources are not necessarily obvious within abm infection spread models. the abm is a spatial-temporal model inclusive of behavioral and interaction patterns between individual agents on a real topography. the agent behaviours (movements and interactions) are fed by census / demographic data, integrated with real data from a telecommunication service provider (cellular records) and person-person contact data obtained via a custom 3g smartphone application that logs bluetooth connectivity between devices. each source provides data of varying type and granularity, thereby enhancing the robustness of the model. the work demonstrates opportunities in data mining and fusion that can be used by policy and decision makers. the data become real-world inputs into individual sir disease spread models and variants, thereby building credible and non-intrusive models to qualitatively simulate and assess public health interventions at the population level. keywords: agent based modeling; personal contact patterns. introduction complex networks underlie the transmission dynamics of many epidemiological models of disease spread, in particular agent based models (abm). network-based epidemiological models use a percolation-like principle to simulate disease spread through the population [1]. agent based models are being increasingly employed due to their potential to capture complex emergent behaviours during the course of an simulated epidemic, where these behaviours arise from the non‐linearities of human-human contacts. abms may employ an explicit or implicit social contact network defined by structured agent interactions. in the explicit case, a disease model (e.g., susceptible ‐ exposed ‐ infected ‐ recovered, seir type) can be implemented directly on the network, although in the case of abm, these resemble simulation models rather than the steady state analysis of network based models mentioned in [1]. in all cases, though, the fidelity of an agent-based model relies in part on the credibility of the social contact network data that feeds it. potential data sources include census and improving agent based models and validation through data fusion 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 demographic data (coarse) and finer-grained data made availability by various means of polling personal electronics such as cell phones. in related work, it was demonstrated that data to model a social contact network can be collected through web services or wireless sensory devices or “motes” worn by individuals in the target population and subsequently used in an infectious disease spread model [2]. such an approach has been previously undertaken to gather data, for example in an organization (workplace or school). the resulting estimated social contact network was used to model an influenza‐like illness (ili) within the setting [3], based on a standard seir type model. in this time‐stepped model, infection spreads between two vertices (individuals) along the weighted edges of the network which represent the amount of social contact between the two individuals. estimating social contact networks in larger populations, (metropolitan scale or larger), is an area of research still in its relative infancy. in cases where precise contact network data is unavailable, an alternative is to mine data as done by episims [4] which uses united states department of transportation information to estimate the schedules of the agents in several metropolitan areas. this presumes that the choices of places for agents to interact is constrained by the transportation network (model), which itself is a complex network. schedules for the agents are synthesized from census and usdot data. a simulation is then run during which a synthetic contact network is constructed from the interactions of the agents and their locations. the resulting dynamic bipartite graph [4] is used to simulate disease spread in the manner stated earlier, except on a much larger scale. both episims and another well‐vetted infectious disease simulator, biowar [5], initially perform validation on model components separately. this is an important component of plausibly reasoned argument, supporting the statement that the model as a whole functions as specified. the objective of the present work is to investigate methods to begin validating abms in varying stages of development by comparing extracted contact networks to known theoretical social contact network models. ideally, networks which embed some notion of space or time will be essential drivers of disease spread in the real world. thus, extracted networks may need to be weighted, for example, to associate weight with the time period during which two agents were in contact. the first such model is of a rural community in the province of manitoba, canada. the emphasis in this work is in integrating data from emerging sources that can be used within discrete time and space disease spread abms. the contagions of interest are influenza like illnesses (ili) or other respiratory infections that are primarily contracted through direct or proximal contact. methods in the first part of the study, we discuss a small scale abm of two adjacent communities in the rural municipality of stanley, manitoba with a combined population of approximately 16,500 residents: winkler, manitoba at 10,000 residents and morden, manitoba at 6500 residents. this is a spatial temporal model with demographic data coming from statistics canada [6]. from this perspective, agents are provided with schedules, and a model of disease spread is run. figure 1 illustrates the topography of the region of interest. improving agent based models and validation through data fusion 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 figure 1: the topography of the rural region of interest the towns of morden and winker are roughly seven miles apart in southwest manitoba. one of the reasons for selecting this area is that it is representative of many north american rural municipalities. figure 1 also illustrates the location of three cellular service towers with mts allstream as the service provider. the abm is discussed in terms of model validation using data that is mined from anonymized cell phone use records. in addition to cell phone usage, the model is also improved using a smartphone application that provides greater fidelity of proximity contacts using bluetooth enabled devices as proxies for people. there are two primary obstacles to fusing data to a model. the first is the collection of the data, with assurances that the data collected is meaningful and accurate, and mining or interpreting the data for parameters or characteristics useful to the model. the second difficulty is integrating the data into the model itself, running simulations and attempting to qualify (and ideally, quantify) the outputs. in many instances, the results of the simulations may be self fulfilling, as in, overcrowding in isolated and impoverished communities leads to increased infection spread. the interventions that one could model may provide guidance for policies that may then be considered. for example, an intervention associated with reducing infection spread may be a recommendation to stay home while ill; in overcrowded residential communities a more effective intervention may be quarantine or a modified quarantine policy whereby an infected person may be advised to seek temporary housing in a facility set up specifically for that purpose. while somewhat self-evident, modeling with real data may help to elucidate these types of options or interventions. the model and abm simulator the model described here is a milestone in the process of designing and implementing an abm simulation framework geared towards high fidelity modeling of human institutions of varying scales. the broad design goals of this framework, called simstitution, are based on the collective experience of the authors gained while developing agent based models of human institutions. originally, models of hospital emergency departments [7] and cities [8] were implemented upon “one-shot” simulators, that is, a simulator strongly coupled to the specific modeling application [9]. a one-shot simulator is comparatively easy to implement, and gives the modeler fine control over the simulator processes, enabling them to fulfill their requirements. typically, in order to minimize development effort, the designer will make assumptions which ease the implementation of the model at hand, without consideration for how these assumptions will constrain or complicate re-purposing the simulator to implement a different model. from a software engineering perspective, part of the reason that one-shot models are so easy to produce is that little or no effort go into making the software reusable or improving agent based models and validation through data fusion 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 extendible. the large number of one-shot simulators observed in the literature [9] is problematic because by their nature they are difficult to re-use. the reusability of the simulator in turn affects the reliability of the simulator; the more researchers that (re)use a particular simulator the more chances that bugs will be identified and fixed. furthermore, when a number of models produce reasonable results using a common simulator, confidence in the credibility of the simulator is increased. publishing results from a series of models built upon a common simulator framework, combined with verification of model components (or submodels), is a common path for building confidence in simulator frameworks for epidemiological modeling [4][5]. simstitution design goals although there are several frameworks [10]-[15] which can be used to develop agent based models, these are dwarfed by the number of one-shot or otherwise domain-specific simulators, suggesting that no framework has yet hit upon a “sweet-spot” between flexibility, extendibility, and specific support classes for human-centric domains [9]. human-centrism includes the notion that agents are spatially oriented and situated since humans are physical entities that occupy and traverse space, rather than existing in some abstract information domain. simulator support for a range of human time steps on the order of seconds to hours or days is also desirable. other design features include adherence to software engineering principles to improve re-use and maintainability of the framework, as well as extendibility especially where machine learning can be leveraged for automated generation of agent policy [16][17]. for rapid model construction, a next generation abm framework should facilitate the incorporation of real-time data such as from database leading to increasingly data-driven simulation. a tool for visualization and interacting with the model in a graphical manner (gui) also facilitates model development, validation, and debugging. visualization is also key for communicating results with subject matter experts and stakeholders [18]. such a visualization tool can also be extended to serve as a tool for model construction or editing model parameters imported from real data. the accessibility of agent behavior development to persons with a non-programming background can be improved by first providing a scripting layer on top of the compiled code, and then perhaps adding a visual or block (e.g. openblocks [19]) programming (drag and drop) on top of that. over time a library of useful scripted behaviors can be built up. the increasing availability of parallel or distributed computing systems also suggests that contemporary or future agent based simulator frameworks have support for distributed, parallel, or cluster computing. the increasing availability of cluster-based compute resources (a consequence of moore’s law), sensitivity to real-time computational constraints, and medical data privacy issues augur well for cluster-based computing. as a result, the simstitution design emphasizes scalability with respect to multiple processors and discrete memory spaces over efficiency in executing one particular type of model. currently, there is an emergence of general-purpose computing on graphics processing units (gpgpu) as excellent accelerators for data parallel applications with regular data access patterns. this leads to opportunities for accelerating agent based simulation as well. however, optimization is still challenging, as the data access patterns are still somewhat irregular for improving agent based models and validation through data fusion 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 most abms. currently, gpus are very well suited to abms that resemble cellular automata, percolation, game-of-life, or particle swarm models. without doubt, higher level abm (social autonomous interacting agents) simulations will also benefit from the compute resources of gpus as the technology evolves (optimizing compilers, etc.). naturally limiting the degree of accessibility of the environment limits what agents can perceive and interact with in the environment (including other agents). localizing agent perception, not only fits in well with the agent paradigm, it also limits to what extent information needs to be shared between processes in a distributed model, which should facilitate using spatial decomposition as a guide for distributing computational load. these disparate goals require balance in feature choice and design. simstitution design details simulated entities within simstitution fall into either of two major categories; agents (simagent), which are the autonomous entities that make decisions and interact with the environment; and instances of the simregion class, which represent spatially partitioned subdivisions of the environment. note from figure 2 that the simobject is abstract, and exists because simagent and simregion have much of their interfaces in common. figure 2: class diagram for core simstitution class hierarchy one of the core design tenets of simstitution is that the spatial division is closely intertwined with the division of computational work across processors and discrete memory boundaries. therefore, simregion is unit of spatial decomposition as well as a convenient unit of computation. in the latter role, it can be considered as a container for agents that need to have their next state computed. figure 3 illustrates the details of this relationship. a particular instance of simregion can be the parent container of simagents or simregions but not both types at the same time. this restriction will in practice result in tree hierarchies of simregions, with simagents contained in the leaf simregions, and the “top region” at the root of the tree. the simregion spatial decomposition granularity becomes increasingly fine away from the root and towards the “leaf regions” of the tree. time advances in the simulation when the simulator advances the time of the top region (root of the tree) by some discrete time step. the top region will then advance the time of its children by the same time step in a recursive fashion such that the tree is traversed in a depth first manner until all the simagents in the leaf regions have been simulated for that time step. the simulator will restart this process again, until a certain number of time steps have elapsed. improving agent based models and validation through data fusion 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 figure 3: relationships between core class instances, forming a tree individualpolicy is a modular unit that affects the behavior of the subscribed simagent, which may also require the individualpolicy to store encapsulated simagent state data specific to that individualpolicy. examples are a schedule policy which causes the simagent to observe a particular day/night work/home schedule, or in the case of a hospital being modeled, a doctor policy which causes the simagent to treat patients within a hospital. within a simregion, each possible concrete derived individualpolicy class has a corresponding grouppolicy for that simregion. the grouppolicy acts as a factory for the corresponding individualpolicy and, if required, facilitates coordination between one or more derived individualpolicy classes (ex. healthcare worker policy in a hospital that coordinates interaction between nurse and doctor individualpolicies). implicit here is the assumption that the properties of the local environment constrain the behavior of agents (ex. airport security lineup, swimming pool, hospital, bank, etc.). the associations between simregion, simagent, grouppolicy, and individualpolicy are shown in figure 4. figure 4: relationships involving modular agent policies communication or interaction between simagents exclusively uses messages passed between simagents. messages received by a simagent are relayed to its individualpolicies which can lead to an internal change of state, or an action to be taken which could lead to additional messages being sent to other individualpolicies on the same subscribed simagent, or messages sent to other simagents. message passing fits well with the agent paradigm, since the alternative implies a direct mapping between external events and internal agent state which violates the principle of agent autonomy [20]. improving agent based models and validation through data fusion 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 details of small town model morden the current work incorporates the framework features mentioned in the previous section, and includes visualization capabilities to observe emergent model behavior during execution. the model is fairly basic so the simregion tree only consists of two layers; the root or top simregion (morden) and the leaf simregions which represent the home, school, and work locations that agents occupy. the leaf simregions are arranged in a grid with empty spaces between structures to allow for simagent travel. agents are assigned work, school, and home locations based on demographic data [6]. figure 5: screenshot of running simulation. morden (left), close-up of 6 classrooms (right). figure 5 shows a screenshot of the morden simulation at a particular time step. on the left side the entire city is shown. on the right is a detailed view of six classrooms in the center of town in which individual simagent details can be seen. details include the gender and age of the simagent, as well as disease status. disease status is the most interesting, and is indicated by the color of the simagent icon. the icon changes color, with green indicating a susceptible state. once the agent is infected it turns yellow, orange, and red depending on how long they have spent in the infected state. finally, recovered simagents turn blue. the leaf simregions are depicted as colored squares where the color of the square shows the aggregated disease state of the simagents within that region. simregions with no simagents contained inside are white. those with one or more simagents display a blended color tile based on the aggregated disease state of the simagents inside. four concrete individualpolicy subclasses were used to generate the simagent behavior in the morden model. the schedulepolicy determines whether a particular agent wants to be at its assigned work, school, or home, depending on the demographic profile of the particular simagent, and the current time which advances in increments of one hour. the schedulepolicy sends messages containing the desired destination to the simagent’s movementpolicy which handles the actual movement. the influenzapolicy maintains the particular simagent’s disease state, and if in the infected state, sends “infection” messages to other simagents in the same simregion, which is how disease spreads between simagents. finally, the bluetoothtrackingpolicy emulates the bluetooth smartphone contact app, and is the source of the synthetic contact data. currently the corresponding grouppolicies were used to facilitate aggregation of data in a spatially explicit manner to achieve the tiling effect in figure 5. improving agent based models and validation through data fusion 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 framework roadmap – next steps the next step or milestone will be to extend the framework by developing modules to simulate finer granularity time and space, namely facilities for agents finding paths and steer through complex environments at time steps on the order of seconds. one such prototypical institutional environment would be improved hospital models [7]. following that, we intend to scale up the number of agents, leveraging parallelism where possible to determine whether spatial partitioning will facilitate execution speedup and if so, under what conditions. in a concurrent development process (possible due to the modularity of the design) tools are also being created to facilitate the integration of increasingly detailed data such as street maps and demographics of places such as morden. in order to promote the ideals of software re-use, once the core simstitution simulator has reached a reasonable level of functional maturity, the code will be made available to other researchers under a general public license. results augmenting data sources in addition to demographic data, the two sources of augmenting data here are associated with coarse grained data from anonymized cellular records and a finer grained smartphone application programmed to log close-proximity bluetooth devices. data from cellular records typically provide service providers with input for network planning, investments, and management of evolving needs. this type of data also has considerable application to public health interests, although at this time it is difficult to derive its direct benefit in contrast to more explicit inputs such as those associated with census and demographic data, due to both technology and policy issues. cellular data data from four consecutive weekdays in november 2010 was extracted from the data provided by the cellular service provider. the data includes the cell tower gps and antenna sector (if applicable) that the mobile device is associated with, the aaa record (every time the phone accesses the network excluding voice and sms), and time stamp of the access. even at four days, this represented just over 14 gb of data. once processed for the connections with the towers of interest (figure 1), this amounted to just under 500,000 records. although statistical in nature, the data can be further processed to estimate flux of persons between the two neighboring towns. within an infection spread model, this type of information helps in estimating patterns of movement that contribute to infection spread. once stored in a database, queries allowed for extracting anonymized device activities. figure 6 illustrates the breakdown of mobile devices accessing the towers in morden and/or winkler. for an individual, a duty cycle can be estimated, illustrating the percentage of time a person is likely to be in one region or another. the timestamp can also be used to infer primary community of residence. users counts here indicate that approximately 2650 users remained in morden, approximately 485 users remained in winkler, while 2285 users spent time in both morden as well as winkler over the four day data collection period. improving agent based models and validation through data fusion 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 figure 6: morden and/or winkler mobile user aggregates this data can be refined further based upon those with access records in both morden and winkler. figure 7 illustrates the breakdown of users who access cell towers in both communities over the duration of a single connection of their cellular device to the network. the actual device accesses between the two communities break down as approximately 65/35, reflecting durations more accurately. figure 7: breakdown of users with records in both communities bluetooth smartphone data the second source of data was a smartphone application designed to poll its local environment on regular intervals for close-proximity bluetooth enabled devices. the application is representative of automated and non-intrusive proximity data collection methods where it is tacitly assumed that consumer electronics serve as proxies for their users. this assumption has limitations, including the disproportionate distribution of cellular devices within a given population to certain demographic subsets; yet, arguably these techniques have increasing credibility as more and more people carry electronic devices. to date, a pilot test has been undertaken with four smartphones collecting data on close-proximity bluetoothenabled devices for just over a three month period. during this time approximately 500,000 records were collected. platforms to date include blackberry storm and htc hero devices. data includes the mac and any assigned meta-identity of both the probe device and the polled (probed) device, the timestamp, and a location if the probe device is gps-enabled. improving agent based models and validation through data fusion 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 figure 8 illustrates samples of the data collected and residing on the database. some records provide more information than others and as such, several records are perhaps more interesting than others. the second highlighted row indicates a device called “general motors”, scanned while the agent 2 probe was on a local highway. many other devices are much more easily identified and more easily associated with actual persons. culling of bluetooth devices that are not obviously a person is possible but not undertaken here at this time. figure 8: a sample of data collected the bluetooth contact data is conjectured to be a type of data that can be described by empirical laws. the distribution used follows the pareto law. pareto's law is given in terms of the cumulative distribution function (cdf), i.e. in this case the number of contacts (nc) with duration larger than or equal to a duration is an inverse power of the duration as expressed below: from the pareto distribution, a power law exponent was calculated and varied from 1.4 to 1.75 for the four probe devices used (r 2 values were consistently above 0.95). a power law exponent less than 2 implies that there is no first moment or mean associated with the distribution. as the data obtained from the probe devices is finite, a mean can be calculated, though. an interesting but not surprising parameter that can be extracted from the pareto principle is the 80/20 rule. from the data collected, the 80/20 rule was applied to indicate the number of contacts that comprised 80% of the total contact duration. from this, it was estimated that 80% of a person’s time is spent with a number of personal contacts that varied between 7 and 20, for the four probe devices. this was extracted from the number and duration of contacts with approximately 5,000 unique bluetooth devices probed. this is consistent with intuition that although the total number of daily contacts may be large, the majority of one’s time is spent with only a small number of people. evolving the abm this section discusses how models, in this case the abm can be improved and validated to some degree through inclusion of as many data sources as practical. the first and most obvious would be using as accurate demographic data as possible. the abm developed here is based on data obtained through the federal census by statistics canada. in addition, models of schools have been refined to provide for reasonable class sizes, data which are estimated here but would benefit from using real data of this type. with this model, a disease spread simulation was run and provided a baseline for modeling the spread of a respiratory improving agent based models and validation through data fusion 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 infection or ili. figure 9 illustrates the spread of a disease among a urban community, represented by morden, in isolation. figure 9: sir disease spread simulation in the first effort to improve the basic abm, it was instrumented in terms of agent contacts and durations which should reflect the patterns in data extracted from the bluetooth probe devices. the objective was to see how well the model reflected real person-person networks. for the baseline simulations of the single town abm typical contact patterns for all agents were instrumented. the results of this analysis are summarized as follows: figure 10: rank ordering of all agents (aggregated) figure 10 illustrates the rank ordering aggregated over all agents. the rank order exponent (zipf’s law) is approximately 1.9. this yields a estimated power law exponent of approximately 1.53. the implication is that an agent’s contact pattern would follow a power law distribution (heavy tail) without finite moments. this result is expected from both the bluetooth proximity pilot as well as well intuitive perceptions of real face-to-face contact patterns. this instrumentation of the abm helps validate it as approximating real world contact patterns. from these abm simulations and the aggregated rank orderings, an 80/20 rule can also be estimated. in this case, 80% of the contact durations are spent with approximately 4% of a person’s contacts (25/670). this again is consistent with data extracted from the bluetooth data collection pilot. figure 11 illustrates the rank ordering of contact parameterized by demographic. intuitively these profiles appear reasonable. school age children spend considerable time with three groups, household members, school classmates, and friends. the knee in the curve of school age children is between 20 and 32. for samples of age groups the exponents associated with zipf’s law are presented in table i. perhaps it is also intuitive that a 2 year old and a 70 year old have similar contact patterns, presumably though improving agent based models and validation through data fusion 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 the 2 year old eats more dirt. also the distribution of the adults perhaps reflects the famous quote by american philosopher and naturalist henry david thoreau who said, “the mass of men lead lives of quiet desperation”. this type of parameter extraction is also consistent with actual survey results reported in [21]. the consequence of the rank ordering implies that the coefficient associated with the corresponding pareto distribution would be between 0 and 1. the lack of a finite mean in the corresponding contact pdf approximation would imply that a few long duration contacts are a significant vector of infection spread. in these cases the (heavy) tail wags the dog. figure 11: rank ordering of agents of different demographics table i. zipf exponents for various demographics age zipf exponent r 2 2 -1.86 0.76 6 -1.51 0.80 12 -1.85 0.78 16 -1.66 0.80 20 -2.0 0.94 30 -1.87 0.96 40 -1.95 0.95 50 -1.95 0.97 70 -1.50 0.85 discussion other means of validating the data from a simulation like this abm includes its relation to other types of published data. for example, in [21] contact patterns are analyzed as derived from a large population survey that indicated that for their preliminary modeling “5to 19year-olds are expected to suffer the highest incidence during the initial epidemic phase of an emerging infection transmitted through social contacts measured here when the population is completely susceptible”. these expectations are consistent with the contact patterns generated by our abm. improving agent based models and validation through data fusion 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 in the second instance of enhancing the abm, it was recognized that morden does not exist in isolation and as such, flux of persons into and out of the area is required. this is not unlike large scale efforts where simulations are based upon data extracted from airline travel, for example. in this case the data albeit voluminous is reasonably extractable. it is more difficult to obtain inter-community travel in rural settings. in this environment, there are few if any directly available data sets but rather opportunities for inferencing from more disparate sources. although an abm running a bounded topography may be applicable to geographically isolated communities, in semi-rural settings there is considerable interaction with surrounding towns that need be accounted for. from figure 6, an indication of interactions between morden and winkler can potentially be inferred from cellular tower access. the data suggests that of the cell phone carrying persons (approximately 4000) with primary residence in morden, approximately 34% are seen to have records in both winkler and morden, with that person spending on average 65% of their time in morden and 35% in winkler. similarly of the approximately 1400 phone carrying persons with primary residence in winker, approximately 65% are seen to have records in both winkler and morden, with that person spending on average 65% of their time in winkler and 35% in morden. these very coarse estimates nonetheless allow one to begin modeling multiple communities and their interactions. one can burrow deeper into the data and determine periods of time a representative individual would spend in each community. further simulations will include representative agent movement trajectories extracted from the cell records integrated into the simulator. figure 12 illustrates a typical duty cycle associated with randomly selected users and their access to cellular towers in morden and winkler. the first two user data duty cycle plots reinforces routine activity theory as users are primarily seen in morden during the night with intertown tower records primarily during the day. the third user’s behavior is considerably more erratic. in either case these types of trajectories are required in improving interacting abms. figure 12: temporal sequence diagram of a user spending accessing towers in morden and winkler model evolution is depicted in figure 13 where external sources are integrated as they become available. at present, these are done in a manual fashion but are amenable to automation improving agent based models and validation through data fusion 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 and/or machine learning further adapting the model to the real world. in general the abm for winkler would follow similar process of development. a benefit to developing abm in this fashion is that they provide opportunities for increasing levels of computational efficiencies by exploiting parallel compute paradigms. figure 13: seir disease spread simulation conclusion this work has demonstrated the potential of incorporating disparate data sources within an infection spread abm with the objective to improve the credibility and validity of the model. the data sources included a smartphone application that estimated proximate contacts and durations to similar devices, serving as proxies for collection of face to face data. the second source of data that is underexploited is associated with cellular phone logs in helping to estimate a person’s trajectory. there are a number of limitations in attempting to incorporate real data from somewhat disparate sources. ideally one would like to compare the output of a disease spread model with major outbreaks. for a number of reasons this is not always possible. the purposes of models are to aid in understanding how effective planned interventions will be in the event of future outbreaks. as such, when using abms, an objective is to make the models as accurate as possible using real data to the greatest degree possible. this is one of the major advantages of using abm, in that they lend themselves to inclusion of real data which is correspondingly becoming increasingly available. although not modeled here, there is also a significant medical facility intermediate between morden and winkler providing an effective vector for infection spread as both patients and health care workers largely come from both morden and winkler corresponding author robert mcloed mcleod@ee.umanitoba.ca mailto:mcleod@ee.umanitoba.ca improving agent based models and validation through data fusion 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 references [1] newman m, spread of epidemic disease on networks. physical review. 2002 jul;66(1):016128. [2] demianyk bcp, sandison d, libbey b, mcleod rd, eskicioglu r, guderian r, friesen mr, ferens k, mukhi, sn. technologies for generating personal social network contact graphs. 2010. ieee healthcom 2010; 2002; lyon, france. [3] salathé m, kazandjieva m, lee jw, levis p, feldman mw, jones jh. a high‐resolution human contact network for infectious disease transmission. pnas, in press 2010. [4] stroud p, del valle s, sydoriak s, riese j, mniszewski s. spatial dynamics of pandemic influenza in a massive artificial rociety. j artificial societies and social simulation. 2007; 10(4)9, http://jasss.soc.surrey.ac.uk/10/4/9.html. [5] carley k, altman n, casman e, fridsma d, yahja a, chen l, kaminsky b, nave d. biowar: scalable agent‐based model of bioattacks. ieee trans on systems, man, and cybernetics. 2006;36:252‐265. [6] statistics canada [internet]. http://www.statcan.gc.ca/ [7] laskowski m, mcleod rd, friesen mr, podaima bw, alfa, as. models of emergency departments for reducing patient waiting times. plos one. 2009;4(7):e6127. [8] borkowski m, podaima bw, mcleod rd. epidemic modeling with discrete space scheduled walkers: possible extensions to hiv/aids. bmc public health. 2009; 9(suppl 1): s14, doi:10.1186/1471-2458-9-s1-s14. [9] uhrmacher a, weyns d, editors. multi-agent systems: simulation and applications. new york: crc press; 2009. . [10] multi-agent simulation environment [internet]. www.simsesam.de [11] modeling & simulation – subproject james ii [internet]. http://wwwmosi.informatik.uni-rostock.de/mosi/projects/cosa/james-ii/ [12] luke s, cioffi-revilla c, panait l, sullivan k, balan g. mason: a multi-agent simulation environment. simulation: trans of the society for modeling and simulation international. 2005;82(7):517-527. [13] spades: system for parallel agent discrete event simulation [internet]. http://spadessim.sourceforge.net/ [14] xj technologies simulation software and services [internet]. http://www.xjtek.com/ [15] swarm development group wiki [internet]. http://www.swarm.org/ [16] miller j. active nonlinear tests (ants) of complex simulation models. manage sci. 1998;44(6):820-30. [17] laskowski m. an agent based decision support framework for healthcare policy, augmented with stateful genetic programming. 2010. ph.d. thesis, u of manitoba. [18] bonabeau e. agent-based modeling: methods and techniques for simulating human systems. proceedings of the national academy of science. 2002;99(suppl 3):72807287, http://www.pnas.org/content/99/suppl.3/7280.full#xref-ref-3-1 [19] mit open blocks download page [internet]. http://education.mit.edu/openblocks [20] parunak hvd. go to the ant: engineering principles from natural multi-agent systems. annals of operations research. 1997;75(0):69-101. [21] mossong j, hens n, jit m, beutels p, auranen k, mikolajczyk et al. social contacts and mixing patterns relevant to the spread of infectious diseases. plos med. 2008;5(3):e74. doi:10.1371/journal.pmed.0050074 ojphi-06-e123.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 57 (page number not for citation purposes) isds 2013 conference abstracts automating biosense 2.0 locker processing for local program-specific surveillance harold gil*, jeffrey johnson, brit colanter and jessica yen county of san diego, health and human services agency, public health services, san diego, ca, usa � �� �� �� � � �� �� �� � objective �������� �� ���� ��� ����� �� ������ ��������� ���� ���� � ����� ���������� �� ����� ����� ��������������� �� �� ��������� ��� �� ����� ��� � �� ���� ���������� �� ��� ��� ��� ������� ���������� introduction ����� � �� ���� ������������� � ������������� ��� ��� ���� ��� �� � ����������������� � ����������������������� � ����� ����� ��� ���� ��� ��������������� �� �� ���� � ��������� ������ � �� � � ������ � ���� ���� ������� ��� ���� ����������� ����� ��� ��� � �� ��� ��������� ����� ��������� ��� ������!� ����� ��� � �� � ����� ��� ���� � ������� ��� ����� �������� �� ������� ��� ��� �������� ������� � �������������� � ��" ��� �� � ���� ����� ��� �� �� � #�������� ���� � ����� ���� �� �������������� � � �� ����� ������ ������� �� ��$�������������� ��% �����&��� � ��������������������� � ��� � ������� ��� �������� ��� � &��'� �������� � &������� � �� � ���� � ����� � ��������������� ����� �� ��������&�� ������� �� � ��� � ���������� ���� �� ��� � ������������'���� ������&������ ��� � ��� ���� ������ ��� ����� ���������������������� � #��� �� ���� ��� (���� ���� ����� �&����� �� � ��� �� �������� ���������������� ���� � ��������� ���)� � � ��� ��� ���� ��� � &������ ��&�������� ���������� ���� ��*��������� � �� �� �� ��� � ������ ����� ��� � �&� ��� �������� �� �� ��������� ��� ���� ���������� �� ��� ����� ��� � ��� ������������ ������������ ������ ��� �� ����� �� ���� ���� �� � ������� ��� ��+ ���, ���� ��� methods !� ��� ��� � ��������� ������� � ������ ����� �� ������� �� ���� ������� �� ���-�������.�� ��� ��� ������$�������������� �� ��� �������� ���� ��� � �� ���/0&��1������2&����� ���� ���� ������ ��&� ������� ���������� ���� ����3������ � � � ��� ������� ����� �� � ������� ��� ��+ ���, ���� ������ �������������������� ������ ��� �� ���� ���������� ��� ��������������� ������������� � � ������ � ���� ��� � ������ �� �� ������ ���� ���� � �� � ��3������� ������ ��������� ���������� � ���� ���� ���� � �� ���� ������������ �������4 �� �, �����!� � ��%���������� �� �� ���� � �������������� ��� � � ��������� �� ��� �������5���� ���� ���� �� ������ ����� � ����� ����������� ����� ���$��� ���� ������&�� ��'� ��������� ��� ��� ���� ��������� &������ � ���������� ���� ���� ���� � �� ���� ������� � ����� ���������� �� �������� � ��� �� ��������� �� ��� �� results 3 �� ���� ��� ���������� � �� � �� �� ������� ��� ��+ ���, �� ��� ��&������ ������ ������������� ����������� ���� �� ���� ��� �� � ������������� �����1���� ��� ��� ��� ��� ���� ���� �� ������ � ��� ������� ��������� ����� ��� �� � ������� � ��������� � � � � ������ ����� �� �� ���� ����������� ���� ��� � �������������� � �� !��� � ����� ��� �� ������ � ���������� ��������� ����� ��� ���� � ��� ����� ��� � ���� ����� ������� ��������$�������������� ��� ��� � � �� ������ �������� ���� �� ��������&� ���� � ������� �� ���� ���� �� ������������������������ �� �������� ��������������������� �������� ��������� � �� ������ ��$��� ���� ����������� � � conclusions ����� ��� �������� ���� �� ��������� ���� �� ����� ������� � � � ��$�������������� � �� ���� � �� ���� �������������% �����&����� ���������� ���� �� ����������� �� � ������������� �������� ����$����� ���������� ������ � � � ���� ��� �� ����� �� � �� ���� ��� �� � �� �������� ������ � ��� �� �� ������ �� � �� ����������� ������ �������������&������� ������������������ ��� ���� � ��$��������� ������ ������ � � � ��� ��� ��� �����&���� � ����� �������� �� �� ����� ��� ��� ���������� ������� ���� ��&�� ������� ���������� �� ������ ��� ������ ������ ������ ����1�������� � ������� ��� �� ������ �������� ���������� ��� ��������������$��������������� ����� �� � ��� �������' � ���� �������� �������������� ��� �������� ���� ��� ��� ��������� keywords � ��� �6�� ���� ���� ��6���� ����6�� ���� ��� � acknowledgments �� �� ����� � ��� ����� ������� �������� �������� �����1��� ���!� � � ��%������(�� ���� � �7��� � � ��!� �������� � ������ ��,��8����� ������� ������,����� �� ��4 �� ��, ��� ������!������ ��),4,*�, �� ���� ���1���������9+9:%"���;<;��;3<� *harold gil e-mail: harold.gil@sdcounty.ca.gov� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e123, 2014 safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention adeola bamgboje-ayodele 1*, leonie ellis1, paul turner1 1. school of technology, environment & design, college of sciences and engineering, university of tasmania, hobart, tasmania, australia abstract objectives: diffusion of smartphones has normalised consumers’ use of mobile applications (apps). but how do app designs and contexts of use interact with differential consumer attributes to impact on their effectiveness, usability and value over time? for consumer food safety, answering these questions is of importance as numerous food choices increase challenges in safe food management (sfm). this research reports on results of a randomised field experiment with australian consumers using an sfm mobile app developed by the researchers. method: the sfm app development employed insights from the health literacy online heuristics framework and the experiment involved evaluation of information and/or knowledge acquisition from the app versus from a paper-based version. the experiment spanned four weeks and involved eight participants (experimental group n=4; control group n=4). results: the results highlight differentials in cognitive burden between paper and the app; beneficial affordances from the app for refreshing consumer knowledge; and longer knowledge retention on safe food management from app use over-time. discussion: we identified two key impacts of the app on consumer knowledge acquisition and knowledge retention. first, the sfm app takes longer to achieve knowledge acquisition but results in longer knowledge retention than the control. second, the sfm app induces some level of cognitive load in adoption however; the affordance of its reuse for quick but infrequent revisitations facilitates knowledge retention. although the study is limited by the small sample size, it however highlights the need for a large scale and purely quantitative investigation that are generalisable to the australian population. conclusion: it is anticipated that the insights gained from this study can be used to develop nationwide interventions for addressing consumer sfm knowledge gaps in the home; thus, moving a step closer towards addressing sfm behaviours of australian consumers. keywords: safe food management, smartphone applications (apps), usability, information modalities, knowledge retention. *correspondence: adeola.bamgboje@utas.edu.au doi: 10.5210/ojphi.v10i3.9542 copyright ©2018 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi 1 introduction alleviating food safety risks is a major source of concern for government authorities, the food industry and increasingly many consumers. diverse mechanisms focused on monitoring and controlling production processes across supply chains, such as iso22000 [1], haccp control systems [2], harpc control systems [3], traceability systems [4], have been employed to address many of these risks. however, most of these food safety mechanisms are largely focused on supply chain activities from ‘paddock-to-purchase’ (pre-purchase) as the legal obligations of supply chain partners on food safety tends to be completed once consumers purchase the products [5]. thus, mitigating food safety risks during the process of consumption (post-purchase), that entails domestic food management from the point of purchase (purchase) to the point of actual consumption (plate), is largely the responsibility of consumers. although the unsettling level of food poisoning outbreaks through domestic food mismanagement from ‘purchase-to-plate’ is not a new phenomenon, the complexity and dynamism of the characteristics of available foods and diversity of consumers has made it very difficult to address. for example; the varying degree of food safety knowledge has facilitated many public food safety information campaigns, education and awareness programs [6]. despite these efforts, many consumers remain inadequately informed about food safety and continue to engage in unsafe food handling practices. there are a range of approaches to support consumers in safe food management including using information and communication technologies (icts), insights from consumer behaviour theory, knowledge management practices and food safety management guidelines. the widespread diffusion of smartphones has now normalised the adoption and use of mobile applications [7]. the highly personalised nature of smartphones embody a potential userempowering characteristic [8], thus providing users with an array of capabilities and experiences that can be tailored to their interests. downloading apps onto their smartphones [9] affords consumers the opportunity to inform themselves about specific areas of interests [10] including safe food management (sfm). consumers can inform themselves about food in terms of tasks such as personalized grocery shopping apps [11], food cooking apps [12] and food storage or wastage apps [13]. this stated, a key question that arises is how do app designs and contexts of use interact with differential consumer attributes to impact on their effectiveness, usability and value over time? these issues can be examined in three ways. first, in terms of the context of use, there is evidence that existing apps provide siloed information about the various aspects (safe shopping, transportation, storage and preparation of perishable food items and appropriate kitchen hygiene practices) of domestic sfm for australian consumers [14]. second, in terms of user experiences, there is insufficient evidence that existing apps have drawn upon information modality studies that highlight differences arising from use of textual [15], visual [16], verbal [17] or integrated information modalities on consumer behaviours pre-purchase. aligned to these studies is the principle of modality effect [18], which argues that materials presented in a format that simultaneously uses the auditory and the visual sensory modality is better than by a format that uses only the visual modality [19]. however, available evidence suggests the use of this principle only within pedagogical frameworks [20] thus, it is unclear if this principle is applicable to adult consumers and whether it will improve user experience during the use of sfm apps. third, there is insufficient evidence to suggest that existing apps in sfm have been comprehensively evaluated [21] or that they were developed based on frameworks guiding mobile health safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi consumer apps. this lack of evidence raises questions about whether best practice guidelines were adhered to. significantly, there is a dearth of research that assesses how well the content of the app has been designed for consumers with considerations for both usability and health literacy. the few evaluations that have been conducted have been restricted to usability assessments and marginalised contexts of use and consumer attributes and behaviours. this research reports on results of a randomised field experiment with australian consumers using a safe food management (sfm) mobile app developed by the researchers to explore these issues more comprehensively. the next section describes the method used in the conduct of this research. 2 method this research adopted an interpretive research philosophy and deployed a mixed-method design structured in three overlapping phases. phase 1 (consumer understanding) involved the conduct of a nationwide survey to identify problems with the current food handling practices of australian consumers and their information and communication preferences (both prepurchase and post-purchase). the findings of this survey have been previously published [5]. this led to the selection of three existing apps (text-based, graphics/picture-based and integrated) that most clearly address the sfm practice being targeted to provide insight into consumers preferred styles of design. phase 2 (design) involved the heuristic evaluation of the three existing apps based on monkman and kushniruk [22] health literacy online heuristics (hloh) framework to identify problems with the apps from an expert’s perspective. following this, a second usability evaluation from the consumers’ perspective, using the apps as a high-fidelity prototype in scenario-based focus group sessions, was conducted. this research activity aimed to identify the impact of the three information modalities on consumer understanding and to generate user requirements for a new app. the outcome of this phase, which has been accepted for publication elsewhere, provided rich insights into consumer requirements for a safe food management app. this led to the design of a single smartphone application (shown in figure 1) for educating and assisting consumers on the sfm practices. safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi figure 1: an enhanced user-centred design approach source: authors phase 3 (implementation and evaluation) involved the actual implementation and evaluation of the app designed in phase 2. phase 3 is the focus of this research paper. after the sfm app was developed, it was evaluated by conducting a randomised field experiment, within a 4-week period. the aim of this research activity was to evaluate the impact of the design on the retention of knowledge on sfm practices over time. 2.1 research design randomised field experiments “allow researchers to scientifically measure the impact of an intervention on a particular outcome of interest through random assignment of study subjects” [23]. it has been argued that randomised field experiments are the ‘gold standard’ as they yield the most accurate analysis of the effect of an intervention [23]. of these techniques, stratified randomization was deemed most appropriate for this research because it addressed the need to balance and control the influence of co-variates in order to avoid any risk to the conclusions of the study [24]. whilst this method is difficult to implement for larger studies, it is deemed more appropriate and simple for smaller studies with limited sample sizes [25]. moreover, it is also appropriate for this study because all the participants were identified through the recruitment process before group assignment [24]. therefore, like skarphedinsson, weidle [26], the authors chose to incorporate stratified randomization. the two key co-variates that might influence the research are gender and age group. in this context an inclusion criterion for each potential participant to fulfil is their ability to purchase and cook meat in their own homes. there is evidence to support the argument that food preparation is still a strongly gendered household task [27]. in agreement, worsley, wang [28] have argued that cooking remains a female responsibility in australia, thus portraying the importance of gender as a co-variate in this study. second, the other criterion is the ownership safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi and use of smartphones. there is also evidence to support the argument that electronic channel preferences through the use of smartphones is a higher preference amongst younger australians [28], thus portraying the importance of age group as a co-variate in this study. to randomize participants, a stratified randomization procedure was applied using gender and age group as stratification variables, to provide a total number of strata of six as much as it was possible based on the available participants. following this, each participant was selected through simple randomization. to ensure that randomization could not be predicted in advance, the randomization procedure utilised tags only. 2.2 participant recruitment participants met the study inclusion criteria if they purchase and cook red meat; if they have a smartphone (specifically an android phone 4.0.3 or an iphone 4 and newer versions) and if they are australian adults (18 years and above). the recruitment efforts spanned across three months and delivered a final group of 12 participants out of which 4 dropped out due to family related issues. 2.3 procedure and research instrument knowledge optimisation involves ensuring that knowledge is acquired, retained and can be applied. drawing upon the revised version of bloom’s taxonomy of meaningful learning [29], achieving knowledge optimisation requires three of the six cognitive processes; remember, understand and apply. in this study, ‘remembrance’ demonstrated the level of knowledge acquired, ‘understanding’ demonstrated the level of knowledge retained and ‘application’ demonstrated the level of knowledge applied. these were assessed using multiple choice questions for knowledge acquisition; a problem based learning approach using scenario-based questions for the knowledge retention; and knowledge application process. following on from similar studies [30], ‘remembering’ has been evaluated after the use of a mobile app for knowledge acquisition [31]. in a study by ahmed and parsons [31], their method involved quantitative assessment through a post-test that was delayed for two-months after the instructional period. they also used questionnaires for the pre and post-tests. furthermore, ‘understanding’ has been evaluated after the use of a mobile app for knowledge acquisition in many studies [32]. what these studies have in common is their use of preand post-test format and multiple choice or short answer questions to assess conceptual understanding [30]. their questions are typically derived from a curriculum, a standardized test, or created by experienced teachers or researchers. in addition, ‘applying’, which is also known as ‘knowledge application’ has been evaluated after the use of a mobile app for knowledge acquisition [33]. in a study by hwang, tsai [33] their method also involved the use of questionnaires for pre and post-tests. it is however worthy to note here that the aforementioned studies on ‘remembering’, ‘understanding’ and ‘applying’ have been conducted based on pedagogical frameworks, as none of those studies have been conducted based on adult learning frameworks situated within the sfm space focused on consumers. on day 1 (pre-test), the 2-hour session started with briefing the participants, providing them with the information sheet and consent form. next, they were provided a 20-item baseline questionnaire which was collected from them after it was answered. following this, those in the experimental group were separately asked to download and install the sfm app on their phone while those in the control group were given a paper-based document. they were asked safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi to use the learning material (app or document) to answer a copy of the unanswered baseline questionnaire given to them. after completing this activity, they were asked to brainstorm on the facts learnt from the learning material within their group. at the end of this session the baseline questionnaire was collected from them, they were allowed to take the learning material home and they were de-briefed. care was taken to ensure the participants in the control group did not have access to the app while those in the experimental group did not have access to the paper-based tool. on day 8 (post-test 1), the same baseline was presented to the participants but with re-ordered questions and answer options. they were not allowed to refer to any learning material. on day 16 (post-test 2), open-ended scenario-based questions that are directly related to the base-line questionnaire were presented to the participants and they were asked to provide short answers to each of the 4 questions. on day 24 (post-test 3), participants were presented with open-ended scenario-based questions that are directly related to the baseline questionnaire but based on raw food products in a kitchen environment. they were asked to provide short answers to each of the 4 questions. this ended with a de-brief. details of the questions are not provided due to space constraints. after the data collection, the data was exported to microsoft excel 2010 for initial formatting and then imported into ibm spss software version 22.0 for better analysis. the data for weeks 1 and 2 were mainly analysed using descriptive statistics while the data for weeks 3 and 4 were first analysed manually based on the correctness of the answers before importing the scores to spss for descriptive analysis. 3 results 3.1 demography of the participants all the respondents live in hobart, tasmania, australia and they are above 18 years of age. the eight participants (4 males and 4 females) were divided into two groups of 4 persons each for the experimental group (app users) and the control group (paper-based tool users). in the experimental group, the highest educational qualification of three of the participants is bachelor or higher, while the fourth participant has a diploma or advanced diploma. all candidates within the control group have a bachelor or higher educational qualification. this is important as it suggests that the participants are learned, and they can easily access, read and understand text presented to them in the experiment. 3.1.1 smartphone usage for the experimental group, all participants within the experiment group own and use a smartphone. 50% of the participants are android phone users while the others use ios-based phones. 50% of the participants have been using a smartphone for more than 4 years while the others have been using smartphones for more than 2 years but less than 4 years. 50% of the participants consider themselves medium smartphone users, 25% regard themselves as light users while 25% believe they are heavy users. for the control group, all participants within the control group own and use a smartphone. 75% of them are ios-based phone users while the others use android phones. 75% of them have been using a smart phone for more than 4 years while the others have been using smartphones for more than 2 years but less than 4 years. 50% of the participants consider themselves medium smartphone users, 25% regard themselves as light users while 25% believe they are very heavy users. safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi therefore, it is reasonable to state that these participants are familiar with the use of smartphones and mobile phone apps. thus, suggesting that they will be able to easily access an app presented to them in the course of the experiment. 3.1.2 food handling for the experimental group, all participants have mixed diet which includes red meat and white meat, which shows that none of them are vegetarians or vegans. 50% of them purchase their meat products from supermarkets, 25% from fresh food markets and 25% from delicatessens. all participants within this group cook raw meat products at least once a week. therefore, this shows that the participants within this group are food handlers in their homes. for the control group, 75% of the participants have mixed diet which includes red meat and white meat, but 25% have mixed diet which includes only red meat. this shows that none of them are vegetarians or vegans. 75% of them purchase their meat products from supermarkets and 25% from fresh food markets. 75% of the participants within this group cook raw meat products at least once a week while others cook raw meat products at least once a fortnight. therefore, this shows that the participants within this group are food handlers in their homes. 3.2 experiment findings this section presents the findings for each week of the field experiment which was conducted to evaluate participants’ level of knowledge acquisition, knowledge retention and knowledge application. 3.2.1 pre-test – week one for all 20 questions all participants were told to select the correct answer based on their current knowledge. each question represents one point. the mean score of the experimental group was 13.25, while the mean score for the control group was 14.75. this reveals that participants in the control group had a better pre-existing knowledge of safe food handling in the home when compared to the experimental group. 3.2.2 post-test 1 – week two the follow up questionnaire (post-test 1) is the same as the baseline questionnaire but the only difference is that the questions and answer options are re-ordered. therefore, there were 20 questions and each participant in both groups was told to select the correct answer based on their current knowledge. each question represents one point. the mean score of the experimental group was 17.5, while the mean score for the control group was 19.75. this reveals that participants in the control group were able to remember what was learnt in the previous week better than the experimental group. 3.2.3 post test 2 – week three in week three, the participants were presented with scenario-based questions that were drawn from, and strongly aligned to, the baseline questionnaire in week one. the focus of this week was for the participants to demonstrate their understanding of the acquired information in the previous weeks. the format of the scenarios would appear familiar to them. there are 4 scenarios, with one scenario for each question. each question is assigned 5 points and points safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi are allocated to each participant based on the correctness of their response. the answers for each question are drawn from the smartphone app or paper-based tool which was provided to the participants in the previous weeks. the mean score of the experimental group was 16.875, while the mean score for the control group was 16.25. this reveals that participants in the experimental group were able to demonstrate a slightly better understanding of what was learnt in the previous weeks better than the control group. 3.2.4 post-test 3 – week four in week four, the participants were presented with open-ended questions based on real scenarios presented to the participants in a kitchen environment. the questions were drawn from, and strongly aligned to, the baseline questionnaire in week one. the focus of this week was for the participants to apply the knowledge they had acquired in the previous weeks. there were four scenarios, with one scenario for each question. for each scenario, a table is presented to each participant with a certain arrangement of food products to support the question being posed. the mean score of the experimental group was 16.375, while the mean score for the control group was 14.875. this reveals that participants in the experimental group were better in applying the knowledge gained within the previous weeks than the control group. 4 discussion as the overarching aim of the research is to provide insights into how best to share information to facilitate knowledge retention through the use of technology in an attempt to improve the food management behaviour of australian consumers, it was imperative to investigate the impact of the sfm app on consumers. whilst two tools (paper-based and app) were involved in the study, the focus was on the app as the paper-based tool was used as a baseline, which contained only textual information modality but the app contained multiple information modalities (text, pictures and videos). therefore, there was a need to understand the impact of the sfm app on consumer knowledge acquisition and knowledge retention on sfm. impact 1: the safe food management (sfm) app requires more time to be spent to achieve knowledge acquisition which resulted in retaining the knowledge for a longer period of time than the traditional information delivery techniques. the authors draw on the cognitive load theory as the tasks and learning activities in the study required simultaneous integration of multiple and various sets of knowledge, skills and behaviours at a specific time and place [34]. the cognitive load theory (clt) integrates three key components of the cognitive architecture: memory systems (sensory, working and longterm memory (ltm)), learning processes and types of cognitive load (intrinsic, extraneous and germane) imposed on working memory (wm) [35]. extraneous cognitive load refers to the burden imposed on the working memory of the learner which is not essential to the task [34]. this load tends to arise when learners use an app at first sight which leads to a distraction that is not related to the knowledge acquisition task. as the initial use of a smartphone app induces a higher level of extraneous cognitive load, this places a level of demand on the working memory and reduces the rate at which knowledge acquisition occurs. according to brunken, plass [18], extraneous cognitive load occurs due to the format and manner of information presentation and the requirements of the instructional activities on the working memory. however, this type and level of cognitive load does not occur when a traditional information delivery technique is used, as evidenced by this study. safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi it was however discovered that the app users demonstrated a higher level of knowledge retention over time when compared to the document users. this could be explained by the splitattention effect in relation to the cognitive load theory. this effect involves the phenomenon whereby the physical integration, rather than physical separation, of verbal and pictorial information sources enhances learning [36]. however, when split attention occurs, it increases demands on the learner’s working memory (wm) and has the tendency to impact learning negatively [37]. one way to avoid the split attention effect is by externally integrating the different sources of information together into a single integrated source of information [37] as was achieved with the sfm app. it is believed that this strategy was instrumental to the successful outcome of the level of knowledge retention emanated by the participants. the app contained videos of sfm practices that incorporated the modality effect as the visual figures are linked with auditory (spoken) rather than visual (written) elements [38]. mayer [38] has argued that the modality effect can only occur under the condition in which the multiple sources of information are unintelligible in isolation and rely on each other for intelligibility to avoid the redundancy effect. this condition was met by the videos included in several pages of the app as they comprised of picture frames (visual elements) and spoken elements that rely on each other for intelligibility; thus complementing the features portrayed by one another [39]. initially, more time was spent on the app used in this study but the rate at which information and/or knowledge was acquired was lower than that of document users. however, more indepth details revealed that the app users acquired the knowledge slowly but retained it longer in contrast to the document users. these findings are in line with the study conducted by herrlinger, höffler [40] and leahy and sweller [41] who have argued that pictures and spoken text enhanced learning better than written text. similar to this finding is the study conducted by wang, tsai [42] which revealed that when more attention was paid to the video and less attention paid to the text there was better retention of the learning outcomes. however, the findings in this study differ from those of chandler and sweller [43] who found that students viewing integrated instruction spent less time processing the materials as the app users in this study spent more time acquiring the knowledge due to the extraneous cognitive load which occurred as a result of the additional learning that was required for the initial use of an app. nonetheless, chandler and sweller [43] also agreed that students viewing integrated instruction outperformed those with split attention condition. on the other hand, the findings are in line with the study conducted by schmidt‐weigand, kohnert [44] who also revealed that participants showed a better learning performance the more time they spent looking at visualizations when text was spoken and integrated. therefore, in consonance with schmidt‐weigand, kohnert [44], it can be argued that the time devoted to process visualizations with spoken and integrated text such as videos may be an indicator of the quality of processing this information. from this perspective, this study suggests that the time a learner spends in using an app containing visualizations with spoken and integrated text such as it is featured in the safe food management (sfm) app, during the information and/or knowledge acquisition phase, may be advantageous in facilitating knowledge retention for a longer period of time than traditional information delivery techniques. impact 2: the sfm app induces some level of cognitive load in adoption however; the affordance of its reuse for quick but infrequent revisitations facilitates knowledge retention. safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi this research has found that the initial use of the smartphone app which was developed for information and/or knowledge acquisition purposes induces a higher level of extraneous cognitive load; thus reducing the rate at which knowledge is acquired during the first use. according to brunken, plass [18], extraneous cognitive load occurs due to the format and manner of information presentation and the requirements of the instructional activities on the working memory. cognitive load was discovered in this study as evidence suggests that participants using the app experienced a level of demand on the working memory. based on arguments from moreno and mayer [45], that the principle of modality effect can indeed reduce extraneous cognitive load for knowledge acquisition tools developed on mobile devices, this study incorporated the principle. yet, the results indicate that some level of cognitive load was induced. although the evidence is lacking, it appears to the authors, that the hloh framework seem to have minimized the cognitive burden. thus, there was a better demonstration of knowledge retention after the app has been reused over a short period of time. when participants spent less time on the smartphone app after the initial use, they demonstrated better retention of knowledge whereas spending more time on the paper-based tool resulted in poorer retention of information and/or knowledge. this finding is in line with the temporal patterns that have been identified in the usage of smartphones and their applications which suggests short bursts of smartphone interactions [46]. for instance, yan, chu [47] found that mobile phone usage is brief as half of mobile phone engagement (time between unlocking and relocking) lasts less than 30 seconds. similarly, ferreira, goncalves [48] found that some apps are used in short bursts of less than 15 seconds. also, a large scale study by böhmer, hecht [49] revealed that smartphone devices are used for an average of 59 minutes daily while an average application session lasts 72 seconds. with a focus on overall smartphone users’ habits, oulasvirta, rattenbury [50] suggest that smartphones are “habit-forming” devices as users emanate the “checking habit” through brief inspection of content quickly accessible on their smartphones. a follow up study by ferreira, goncalves [48] revealed that this habit is one of the behavioural characteristics that leads to short bursts of interactions with applications. in addition, this habit has largely been focused on users making quick revisits to applications that contain fast changing content [48,50]. however, jones, ferreira [46] has argued that apps that relate to personal activities such as food handling and food management follow a slow revisitation pattern. as such, this explains the slow revisitation pattern and the little time spent on the sfm app during its subsequent use in this study. thus, as this facilitated a better demonstration of knowledge retention on safe food management, it suggests that the affordance of re-use for quick but infrequent revisitations facilitates knowledge retention. therefore, as it has been earlier argued that multiple information channels enhance food safety information dissemination [51], it can be further argued that other information channels such as tv adverts, brochures, pamphlets and other media can be useful in drawing attention to the reuse or revisitation of such smartphone apps to reinforce and support the retention of consumer knowledge. this indicates that optimising consumers’ safe food management knowledge cannot be a one-off activity as they require cues that prompt them into revising the app so as to maintain adequate knowledge level from time to time. 5 limitations due to the difficulty in recruiting a sample that was representative of the australian population, participants were limited to consumers in hobart, tasmania; thus, the outcome of the research safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi may be skewed. based on this small number of participants, the findings of this study cannot be generalised to the australian population and it may lead to a possibility of potential alternative explanations for the findings which favoured the use of the app rather than the document for knowledge retention. as such further large-scale studies would need to be conducted based on a sample that is representative of the australian population. 6 conclusion this research was focused on investigating how the affordances of smartphone technology can be leveraged to enhance the provision of information and facilitate knowledge retention as a step towards improving the sfm behaviour of australian consumers. this paper has presented findings from a randomised field experiment using a developed sfm app for information and/or knowledge acquisition as the intervention and a paper-based document as control with assessments conducted at baseline, week 2, 3 and 4. we identified 2 key impacts of the app on consumer knowledge acquisition and knowledge retention. first, we discovered that the safe food management (sfm) app requires more time to be spent to achieve knowledge acquisition which resulted in retaining the knowledge for a longer time than the traditional information delivery techniques. second, we found that the sfm app induces some level of cognitive load in adoption however; the affordance of its reuse for quick but infrequent revisitations facilitates knowledge retention. it is anticipated that the insights gained from this study can be used to develop nationwide interventions for addressing consumer sfm knowledge gaps in the home; thus moving a step closer towards addressing sfm behaviours of australian consumers. 7 references 1. varzakas th, arvanitoyannis is. 2008. application of iso22000 and comparison to haccp for processing of ready to eat vegetables: part i. int j food sci technol. 43(10), 1729-41. https://doi.org/10.1111/j.1365-2621.2007.01675.x 2. unnevehr lj, jensen hh. 1999. the economic implications of using haccp as a food safety regulatory standard. food policy. 24(6), 625-35. doi:https://doi.org/10.1016/s03069192(99)00074-3. 3. grover ak, chopra s, mosher ga. 2016. food safety modernization act: a quality management approach to identify and prioritize factors affecting adoption of preventive controls among small food facilities. food control. 66, 241-49. https://doi.org/10.1016/j.foodcont.2016.02.001 4. regattieri a, gamberi m, manzini r. 2007. traceability of food products: general framework and experimental evidence. j food eng. 81(2), 347-56. doi:https://doi.org/10.1016/j.jfoodeng.2006.10.032. 5. wu c-c, wu c-h, li c-c, huang t-h. 2011. drivers of organizational knowledge management. afr j bus manag. 5(11), 4388-402. doi:10.5897/ajbm10.1415. 6. verbeke w, frewer lj, scholderer j, de brabander hf. 2007. why consumers behave as they do with respect to food safety and risk information. anal chim acta. 586(1), 2-7. pubmed https://doi.org/10.1016/j.aca.2006.07.065 https://doi.org/10.1111/j.1365-2621.2007.01675.x https://doi.org/10.1016/s0306-9192(99)00074-3 https://doi.org/10.1016/s0306-9192(99)00074-3 https://doi.org/10.1016/j.foodcont.2016.02.001 https://doi.org/10.1016/j.jfoodeng.2006.10.032 https://www.ncbi.nlm.nih.gov/pubmed/17386689 https://doi.org/10.1016/j.aca.2006.07.065 safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi 7. luxton dd, mccann ra, bush ne, mishkind mc, reger gm. 2011. mhealth for mental health: integrating smartphone technology in behavioral healthcare. prof psychol res pr. 42(6), 505. https://doi.org/10.1037/a0024485 8. tossell cc, kortum p, shepard c, rahmati a, zhong l. 2012. an empirical analysis of smartphone personalisation: measurement and user variability. behav inf technol. 31(10), 995-1010. https://doi.org/10.1080/0144929x.2012.687773 9. jung y. 2014. what a smartphone is to me: understanding user values in using smartphones. inf syst j. 24(4), 299-321. doi:https://doi.org/10.1111/isj.12031. 10. verkasalo h, lópez-nicolás c, molina-castillo fj, bouwman h. 2010. analysis of users and non-users of smartphone applications. telemat inform. 27(3), 242-55. https://doi.org/10.1016/j.tele.2009.11.001 11. clear ak, friday aj, rouncefield mf, chamberlain a. 2015. supporting sustainable food shopping. ieee pervasive comput. 14(4), 28-36. https://doi.org/10.1109/mprv.2015.78 12. bähler a. smart recipes: swiss federal institute of technology, zurich; 2015. 13. farr-wharton g, choi jh-j, foth m, eds. food talks back: exploring the role of mobile applications in reducing domestic food wastage. proceedings of the 26th australian computer-human interaction conference on designing futures: the future of design; 2014: acm. 14. henley sc, stein se, quinlan jj. 2012. identification of unique food handling practices that could represent food safety risks for minority consumers. j food prot. 75(11), 205054. pubmed https://doi.org/10.4315/0362-028x.jfp-12-146 15. blanco cf, sarasa rg, sanclemente co. 2010. effects of visual and textual information in online product presentations: looking for the best combination in website design. eur j inf syst. 19(6), 668-86. https://doi.org/10.1057/ejis.2010.42 16. ha y, lennon sj. 2010. online visual merchandising (vmd) cues and consumer pleasure and arousal: purchasing versus browsing situation. psychol mark. 27(2), 141-65. https://doi.org/10.1002/mar.20324 17. kim m, lennon s. 2008. the effects of visual and verbal information on attitudes and purchase intentions in internet shopping. psychol mark. 25(2), 146-78. https://doi.org/10.1002/mar.20204 18. brunken r, plass jl, leutner d. 2003. direct measurement of cognitive load in multimedia learning. educ psychol. 38(1), 53-61. https://doi.org/10.1207/s15326985ep3801_7 19. mayer re, chandler p. 2001. when learning is just a click away: does simple user interaction foster deeper understanding of multimedia messages? j educ psychol. 93(2), 390. https://doi.org/10.1037/0022-0663.93.2.390 https://doi.org/10.1037/a0024485 https://doi.org/10.1080/0144929x.2012.687773 https://doi.org/10.1111/isj.12031 https://doi.org/10.1016/j.tele.2009.11.001 https://doi.org/10.1109/mprv.2015.78 https://www.ncbi.nlm.nih.gov/pubmed/23127716 https://doi.org/10.4315/0362-028x.jfp-12-146 https://doi.org/10.1057/ejis.2010.42 https://doi.org/10.1002/mar.20324 https://doi.org/10.1002/mar.20204 https://doi.org/10.1207/s15326985ep3801_7 https://doi.org/10.1037/0022-0663.93.2.390 safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi 20. harskamp eg, mayer re, suhre c. 2007. does the modality principle for multimedia learning apply to science classrooms? learn instr. 17(5), 465-77. doi:https://doi.org/10.1016/j.learninstruc.2007.09.010. 21. oliveira lcrd. mitchell va, may aj. designing a smart phone app for sustainable cooking. proceedings of the 2013 acm conference on pervasive and ubiquitous computing adjunct publication; zurich, switzerland. 2497315: acm; 2013. p. 585-8. 22. monkman h, kushniruk a, eds. a health literacy and usability heuristic evaluation of a mobile consumer health application. medinfo; 2013. 23. isps. why randomize? field experiments initiative [internet]. 2012 15/02/2016. available from: http://isps.yale.edu/node/16697#.vsepdpl9670. 24. suresh k. 2011. an overview of randomization techniques: an unbiased assessment of outcome in clinical research. j hum reprod sci. 4(1), 8. pubmed https://doi.org/10.4103/0974-1208.82352 25. shen d, lu z. randomization in clinical trial studies. 2006. 26. skarphedinsson g, weidle b, thomsen ph, dahl k, torp nc, et al. 2015. continued cognitive-behavior therapy versus sertraline for children and adolescents with obsessive– compulsive disorder that were non-responders to cognitive-behavior therapy: a randomized controlled trial. eur child adolesc psychiatry. 24(5), 591-602. pubmed https://doi.org/10.1007/s00787-014-0613-0 27. hartmann c, dohle s, siegrist m. 2013. importance of cooking skills for balanced food choices. appetite. 65, 125-31. pubmed doi:https://doi.org/10.1016/j.appet.2013.01.016. 28. worsley a, wang w, ismail s, ridley s. 2014. consumers’ interest in learning about cooking: the influence of age, gender and education. int j consum stud. 38(3), 258-64. doi:https://doi.org/10.1111/ijcs.12089. 29. mayer re. 2002. rote versus meaningful learning. theory pract. 41(4), 226-32. https://doi.org/10.1207/s15430421tip4104_4 30. zydney jm, warner z. 2016. mobile apps for science learning: review of research. comput educ. 94, 1-17. https://doi.org/10.1016/j.compedu.2015.11.001 31. ahmed s, parsons d. 2013. abductive science inquiry using mobile devices in the classroom. comput educ. 63, 62-72. doi:https://doi.org/10.1016/j.compedu.2012.11.017. 32. chiang th, yang sj, hwang g-j. 2014. an augmented reality-based mobile learning system to improve students’ learning achievements and motivations in natural science inquiry activities. j educ technol soc. 17(4), 352-65. 33. hwang g-j, tsai c-c, chu h-c, kinshuk k, chen c-y. 2012. a context-aware ubiquitous learning approach to conducting scientific inquiry activities in a science park. australas j educ technol. 28(5), 931-47. https://doi.org/10.14742/ajet.825 https://doi.org/10.1016/j.learninstruc.2007.09.010 https://www.ncbi.nlm.nih.gov/pubmed/21772732 https://doi.org/10.4103/0974-1208.82352 https://www.ncbi.nlm.nih.gov/pubmed/25239489 https://doi.org/10.1007/s00787-014-0613-0 https://www.ncbi.nlm.nih.gov/pubmed/23402717 https://doi.org/10.1016/j.appet.2013.01.016 https://doi.org/10.1111/ijcs.12089 https://doi.org/10.1207/s15430421tip4104_4 https://doi.org/10.1016/j.compedu.2015.11.001 https://doi.org/10.1016/j.compedu.2012.11.017 https://doi.org/10.14742/ajet.825 safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi 34. young jq, van merrienboer j, durning s, ten cate o. 2014. cognitive load theory: implications for medical education: amee guide no. 86. med teach. 36(5), 371-84. pubmed https://doi.org/10.3109/0142159x.2014.889290 35. sweller j. 1988. cognitive load during problem solving: effects on learning. cogn sci. 12(2), 257-85. https://doi.org/10.1207/s15516709cog1202_4 36. cierniak g, scheiter k, gerjets p. 2009. explaining the split-attention effect: is the reduction of extraneous cognitive load accompanied by an increase in germane cognitive load? comput human behav. 25(2), 315-24. https://doi.org/10.1016/j.chb.2008.12.020 37. ayres p, cierniak g. split-attention effect. encyclopedia of the sciences of learning. springer; 2012. p. 3172-5. 38. mayer re. principles for managing essential processing in multimedia learning: segmenting, pretraining, and modality principles. the cambridge handbook of multimedia learning. 2005:169-82. 39. liu t-c, lin y-c, tsai m-j, paas f. 2012. split-attention and redundancy effects on mobile learning in physical environments. comput educ. 58(1), 172-80. https://doi.org/10.1016/j.compedu.2011.08.007 40. herrlinger s, höffler tn, opfermann m, leutner d. 2016. when do pictures help learning from expository text? multimedia and modality effects in primary schools. res sci educ. 47(3), 1-20. doi:10.1007/s11165-016-9525-y. 41. leahy w, sweller j. 2011. cognitive load theory, modality of presentation and the transient information effect. appl cogn psychol. 25(6), 943-51. https://doi.org/10.1002/acp.1787 42. wang c-y, tsai m-j, tsai c-c. 2016. multimedia recipe reading: predicting learning outcomes and diagnosing cooking interest using eye-tracking measures. comput human behav. 62, 9-18. https://doi.org/10.1016/j.chb.2016.03.064 43. chandler p, sweller j. 1992. the split-attention effect as a factor in the design of instruction. br j educ psychol. 62(2), 233-46. doi:https://doi.org/10.1111/j.20448279.1992.tb01017.x. 44. schmidt‐weigand f, kohnert a, glowalla u. 2010. explaining the modality and contiguity effects: new insights from investigating students’ viewing behaviour. appl cogn psychol. 24(2), 226-37. https://doi.org/10.1002/acp.1554 45. moreno r, mayer re. 2005. role of guidance, reflection, and interactivity in an agentbased multimedia game. j educ psychol. 97(1), 117. https://doi.org/10.1037/00220663.97.1.117 46. jones sl, ferreira d, hosio s, goncalves j, kostakos v. revisitation analysis of smartphone app use. proceedings of the 2015 acm international joint conference on pervasive and ubiquitous computing; osaka, japan. 2807542: acm; 2015. p. 1197-208. https://www.ncbi.nlm.nih.gov/pubmed/24593808 https://doi.org/10.3109/0142159x.2014.889290 https://doi.org/10.1207/s15516709cog1202_4 https://doi.org/10.1016/j.chb.2008.12.020 https://doi.org/10.1016/j.compedu.2011.08.007 https://doi.org/10.1002/acp.1787 https://doi.org/10.1016/j.chb.2016.03.064 https://doi.org/10.1111/j.2044-8279.1992.tb01017.x https://doi.org/10.1111/j.2044-8279.1992.tb01017.x https://doi.org/10.1002/acp.1554 https://doi.org/10.1037/0022-0663.97.1.117 https://doi.org/10.1037/0022-0663.97.1.117 safe food management and smartphone technology: investigating the impact of an app on consumer knowledge retention online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e222, 2018 ojphi 47. yan t, chu d, ganesan d, kansal a, liu j, eds. fast app launching for mobile devices using predictive user context. proceedings of the 10th international conference on mobile systems, applications, and services; 2012: acm. 48. ferreira d, goncalves j, kostakos v, barkhuus l, dey ak, eds. contextual experience sampling of mobile application micro-usage. proceedings of the 16th international conference on human-computer interaction with mobile devices & services; 2014: acm. 49. böhmer m, hecht b, schöning j, krüger a, bauer g, eds. falling asleep with angry birds, facebook and kindle: a large scale study on mobile application usage. proceedings of the 13th international conference on human computer interaction with mobile devices and services; 2011: acm. 50. oulasvirta a, rattenbury t, ma l, raita e. 2012. habits make smartphone use more pervasive. pers ubiquitous comput. 16(1), 105-14. https://doi.org/10.1007/s00779-0110412-2 51. kuttschreuter m, rutsaert p, hilverda f, regan á, barnett j, et al. 2014. seeking information about food-related risks: the contribution of social media. food qual prefer. 37, 10-18. https://doi.org/10.1016/j.foodqual.2014.04.006 https://doi.org/10.1007/s00779-011-0412-2 https://doi.org/10.1007/s00779-011-0412-2 https://doi.org/10.1016/j.foodqual.2014.04.006 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts coverage and timeliness of combined military and veteran surveillance systems howard s. burkom1, yevgeniy elbert1, carla winston2, julie pavlin*3, cynthia luceroobusan2 and mark holodniy2 1johns hopkins university applied physics laboratory, laurel, md, usa; 2veterans health administration, palo alto, ca, usa; 3armed forces health surveillance center, silver spring, md, usa objective we determined the utility and effective methodology for combining patient record information from the departments of veterans affairs (va) and defense (dod) health surveillance systems. introduction an objective of the joint va/dod biosurveillance system for emerging biological threats project is to improve situational awareness of the health of combined va and dod populations. dod and va both use versions of the electronic surveillance system for the early notification of community-based epidemics (essence). with a retrospective outpatient data collection available, we analyzed relative coverage and timeliness of the two systems to understand potential benefits of a joint system. methods we used the us office of management and budget’s core-based statistical area (cbsa) to group data from the respective systems by megapolitan (>1 million), metropolitan (50,000-1 million) and micropolitan (10,000-50,000) areas. we performed frequency analyses and mapped coverage of the va and dod medical systems in these cbsas. to determine comparability, we compared international classification of diseases, 9th revision (icd-9) code usage from 2007-2010 by age group in the respective systems and then formulated a working definition of influenza-like illness (ili). we then compared cbsa-level temporal detection timeliness in the two systems for the h3n2 epidemic of 2007-9 and the h1n1 pandemic in 2009. results we identified a total of 939 cbsas, with generally diffuse geographic coverage by va facilities and higher concentration in larger metro and mega areas for dod facilities. of the 51 mega cbsas, all have at least one va facility and 63% have a dod facility. coverage is sparser for the metro cbsas and lighter still for the micro cbsas (table 1). although the va coverage is greater, in many cbsas with dual coverage, the dod visit volume is comparable or greater. patient age distribution differs sharply, with >85% of the va patients over 45 years of age compared to 22% of dod patients. for all cbsas, the overall va/dod visit ratio is 1.92, but the ratios for 0-17 years is 0.004, 18-44 years 0.33, 45-64 years 5.20 and >65 years 11.63. based on an analysis of icd-9 codes used in the two systems, the dod uses symptom-based ili codes far more frequently than the va, especially codes for diseases often seen in children (e.g., otitis media). analysis of ili-related codes assigned in both systems led to a common code set for comparative analysis. from applying alerting algorithms to visit counts based on this code set, detection was better in dod data for 57% and 77% of cbsas for seasonal and pandemic influenza, respectively, and better in va data for 37% and 14% of cbsas (table 2). the va system performed better during the typical h3n2 seasonal flu compared to the h1n1 outbreak. the dod system performed better during the h1n1 pandemic, although outperformed the va for both. conclusions the coverage analysis demonstrates two complementary surveillance systems with evident benefits to a fused national health picture. the va system patient volume roughly doubles the dod system, and provides better geographic coverage in smaller cbsas; however, the dod includes younger populations, better coverage in strategic metro areas, and more pre-diagnostic ili coding. from analysis of both outbreaks, relative timeliness could be improved in 92% of cbsas with access to both systems, with more information provided in cbsas where only one type of facility exists. table 1. counts of cbsas containing va and dod facilities table 2. relative timeliness by cbsas with both dod and va facilities with a minimum average of 2 ili visits/week keywords syndromic surveillance; merged systems; government *julie pavlin e-mail: julie.pavlin@us.army.mil online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e39, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a syndromic approach to emergency department surveillance for skin and soft tissue infections larissa may*1, marcus rennick2, leah gustafson1 and julia gunn2 1emergency medicine, the george washington university, washington, dc, usa; 2boston public health commission, boston, ma, usa objective we sought to describe the epidemiology of emergency department (ed) visits for skin and soft tissue infections (ssti) in an urban area with diverse neighborhood populations using syndromic surveillance system data for the time period from 2007-2011. our aims were threefold: to demonstrate a proof of concept using syndromic surveillance for ssti surveillance in the absence of laboratory data, to estimate the burden of ed visits associated with ssti, and to determine potential geographic “hotspots” for these infections. introduction the incidence of and hospitalizations for ssti have steadily increased over the last decade in the united states, primarily due to the emergence and spread of community acquired methicillin resistant staphylococcus aureus (ca-mrsa). the ed is a common site for ssti treatment and serves populations not captured by traditional surveillance, including the homeless and uninsured. the use of near real-time syndromic surveillance within the ed to detect unusual activity for further public health investigation has been used to augment traditional infectious disease surveillance. however, the use of this approach for monitoring local epidemiologic trends in ssti presentation where laboratory data are not available, has not previously been described. methods we sought to describe the epidemiology of ed visits for ssti in an urban area with diverse neighborhood populations using the boston public health commission’s (bphc) syndromic surveillance system (bsynss) data for a five year time period (2007 through 2011). ssti related visits were defined by either chief complaints with ssti associated words (abscess, cellulitis) or final diagnosis international classification of diseases (icd-9 cm) codes for sstis. ssti related visits were de-duplicated using demographics and visit identifiers and then stratified by age group, gender, race, and neighborhood of residence defined by zip code. each of boston’s 15 neighborhoods has a unique demographic profile with distinct differences in race, socioeconomic status, and age. finally, we examined trends in characteristics of potential “hotspots” of neighborhood clustering for sstis in eds. results using our ssti syndrome definition, we estimated unique ssti visits represented 3.29 % (n= 45,252) of all visits within boston’s ten eds during the study period with a seasonal pattern peaking during the summer months (july through september). the majority of ssti visits (54%) were among patients 18 to 44 years old, which is consistent with the age distribution of the boston population. however, a disproportionate number of ssti visits (43%) were among black patients when compared to both the overall boston population (22% black) and to the racial distribution of all ed visits (39% black). the five-year average rate of ssti visits for black patients (281.2 per 10,000 population) was significantly greater at 2.8 times [ci 2.7, 3.0] than the rate for white patients (99.0 per 10,000 population). geographic neighborhood distribution of ssti visits ranged from a low of 2.69% to a high of 4.11% of all neighborhood-specific ed visits. disposition data are available for 2010 and 2011 only and show that 24% and 23% of patients in 2010 and 2011, respectively, were admitted for their ssti. conclusions our study results suggest that syndromic surveillance data can be used to track the burden and patterns of ssti in an urban population, including disease severity through the use of disposition data. furthermore, syndromic surveillance can provide information on the local epidemiology of ssti, including data related to health inequalities. the burden of sstis should be compared to overall ed use for a specific population to control for biases in health care seeking behaviors and choice of provider type. a local syndromic surveillance system has the potential to provide public health authorities and ed clinicians near real-time monitoring of trends in severity and demographic risk factors, and may provide an alternative to tracking the severity of illness where no laboratory data are readily available. keywords syndromic surveillance; epidemiology; skin and soft tissue infections; racial disparities *larissa may e-mail: larissa.may@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e61, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts tweeting fever: are tweet extracts a valid surrogate data source for dengue fever? jacqueline s. coberly*1, clayton r. fink1, eugene elbert1, in-kyu yoon2, john m. velasco2, agnes tomayo2, v. roque3, s. ygano4, durinda macasoco4 and sheri lewis3 1the johns hopkins university applied physics laboratory, laurel, md, usa; 2armed forces research institute for medical research, bangkok, thailand; 3national epidemiology center, manila, philippines; 4cebu city health office, cebu city, philippines objective to determine whether twitter data contains information on dengue-like illness and whether the temporal trend of such data correlates with the incidence dengue or dengue-like illness as identified by city and national health authorities. introduction dengue fever is a major cause of morbidity and mortality in the republic of the philippines (rp) and across the world. early identification of geographic outbreaks can help target intervention campaigns and mitigate the severity of outbreaks. electronic disease surveillance can improve early identification but, in most dengue endemic areas data pre-existing digital data are not available for such systems. data must be collected and digitized specifically for electronic disease surveillance. twitter, however, is heavily used in these areas; for example, the rp is among the top 20 producers of tweets in the world. if social media could be used as a surrogate data source for electronic disease surveillance, it would provide an inexpensive pre-digitized data source for resource-limited countries. this study investigates whether twitter extracts can be used effectively as a surrogate data source to monitor changes in the temporal trend of dengue fever in cebu city and the national capitol region surrounding manila (ncr) in the rp. methods we obtained two sources of ground truth incidence for dengue. the first was daily dengue fever incidence for cebu city and the ncr taken from the philippines integrated disease surveillance and response system (pidsr). the second ground truth source was fever incidence from cebu city for 2011. the cebu city health office (ccho) has monitored fever incidence as a surrogate for dengue fever since the 1980s. tweets from cebu city, and the ncr were collected prospectively thru twitter’s public application program interface. the cebu city fever ground truth data set was smoothed with a seven day moving average to facilitate comparison to the pidsr and twitter data. a vocabulary of words and phrases describing fever and dengue fever in the tweets collected were identified and used to mark relevant tweets. a subset of these ‘fever’ tweets that mentioned fever related to a medical situation were identified. the incidence and the temporal pattern of these medically-relevant tweets were compared with the incidence and pattern of fever and dengue fever in the two ground truth data sets. pearson correlation coefficient was used to compare the correlation among the different data sets. noted lag periods were adjusted by moving the data in time and re-computing the correlation coefficient. results 26,023,103 tweets were collected from the two geographic regions: 10,303,366 from cebu city and 15,719,767 tweets from the ncr. 8,814 (0.02%) tweets contained the word fever and 4099 (0.01% of total) mentioned fever in a medically-relevant context, for example. “…i have a fever…” vs. “…football fever….” the medically-relevant tweets were compared with both ground truth data sets. the correlation between the tweets and each of the incidence data sets is shown below. conclusions tweets containing medically-relevant fever references were correlated (p<0.0001) with both fever and dengue fever incidence in the ground truth data sets. the signal indicating fever in the medicallyrelated tweets led the incidence data significantly: by 6 days for the cebu city fever incidence; and by 12 days for the pidsr dengue fever incidence. temporal adjustment to account for observed lag periods increased the correlation coefficient by about one-third in both cases. this was a limited pilot study, but it suggests that twitter extracts may provide a valid and timely surrogate data source to monitor dengue fever in this population. further study of the correlation of twitter and dengue in other areas, and of twitter with other illnesses is warranted. table 1: correlation between twitter extracts and fever & dengue fever incidence data sets * p<0.0001 † twitter shifted right by 6 days ‡ twitter shifted right by 12 days keywords dengue; social media; twitter *jacqueline s. coberly e-mail: jacqueline.coberly@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e64, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts bayesian contact tracing for communicable respiratory disease ayman shalaby* and daniel lizotte university of waterloo, waterloo, on, canada objective the purpose of our work is to develop a system for automatic contact tracing with the goal of identifying individuals who are most likely infected, even if we do not have direct diagnostic information on their health status. control of the spread of respiratory pathogens (e.g. novel influenza viruses) in the population using vaccination is a challenging problem that requires quick identification of the infectious agent followed by large-scale production and administration of a vaccine. this takes a significant amount of time. a complementary approach to control transmission is contact tracing and quarantining, which are currently applied to sexually transmitted diseases (stds). for stds, identifying the contacts that might have led to disease transmission is relatively easy; however, for respiratory pathogens, the contacts that can lead to transmission include a huge number of face-to-face daily social interactions that are impossible to trace manually. introduction the evolution of novel influenza viruses in humans is a biological phenomenon that can not be stopped. all existing data suggest that vaccination against the morbidity and mortality of the novel influenza viruses is our best line of defence. unfortunately, vaccination requires that the infectious agent to be quickly identified and a safe vaccine in large quantities is produced and administered. as was witnessed with the 2009 h1n1 influenza pandemic, these steps took a frustratingly long period during which the novel influenza virus continued its unstoppable and rapid global spreading. in addition to the different vaccination strategies ( e.g. random mass vaccination, age structured vaccination), isolation and quarantining of infected individuals is another effective method used by the public health agencies to control the spreading of infectious diseases. isolation is effective against any infectious disease, however it can be very hard to detect infectious individuals in the population when: 1. symptoms are ambiguous or easily misdiagnosed ( e.g. 2009 h1n1 influenza outbreak shared many symptoms with many other influenza like illnesses) 2. when the symptoms emerge after the individual become infectious. methods we developed a dynamic bayesian network model to process sensor information from users’ cellphones together with (possibly incomplete) diagnosis information to track the spread of disease in a population. our model tracks real-time proximity contacts and can provide public health agencies with the probability of infection for each individual in the model. for testing our algorithm, we used a real-world mobile sensor dataset with 120 individuals collected over a period of 9 months, and we simulated an outbreak. results we ran several experiments where different sub-populations were “infected” and “diagnosed.” by using the contact information, our model was able to automatically identify individuals in the population who were likely to be infected even though they were not directly “diagnosed” with an illness. conclusions automatic contact tracing for respiratory pathogens is a powerful idea, however we have identified several implementation challenges. the first challenge is scalability: we note that a contact tracing system with a hundred thousand individuals requires a bayesian model with a billion nodes. bayesian inference on models of this scale is an open problem and an active area of research. the second challenge is privacy protection: although the test data were collected in an academic setting, deploying any system will require appropriate safeguards for user privacy. nonetheless, our work llustrates the potential for broader use of contact tracing for modeling and controlling disease transmission. keywords outbreak detection; syndromic surveillance; mobile; contact tracing; bayesian algorithms *ayman shalaby e-mail: aymanshalaby11@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e208, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts an integrated syndromic surveillance system for monitoring scarlet fever in taiwan wan-jen wu*, yu-lun liu, hung-wei kuo, wan-ting huang, shiang-lin yang and jenhsiang chuang epidemic intelligence center, taiwan centers for disease control, taipei city, taiwan objective to develop an integrated syndromic surveillance system for timely monitoring and early detection of unusual situations of scarlet fever in taiwan, since hong kong, being so close geographically to taiwan, had an outbreak of scarlet fever in june 2011. introduction scarlet fever is a bacterial infection caused by group a streptococcus (gas). the clinical symptoms are usually mild. before october, 2007, case-based surveillance of scarlet fever was conducted through notifiable infectious diseases in taiwan, but was removed later from the list of notifiable disease because of improved medical care capacities. in 2011, hong kong had encountered an outbreak of scarlet fever (1,2). in response, taiwan developed an integrated syndromic surveillance system using multiple data sources since july 2011. methods more than 99% of the taiwan population is covered by national health insurance. we first retrospectively evaluated claims data from the bureau of national health insurance (bnhi) by comparing with notifiable diseases reporting data from taiwan centers for disease control (tcdc). the claims data included information on scarlet fever diagnosis (icd-9-cm code 034.1), date of visits, location of hospitals and age of patients from outpatient (opd), emergency room (er) and hospital admissions. daily aggregate data of scarlet fever visits or hospitalizations were prospectively collected from bnhi since july 2011. over 70% of the deaths in taiwan are reported to the office of statistics of department of health electronically. we obtained daily data on electronic death certification data and used sas enterprise guide 4.3 (sas institute inc., cary, nc, usa) for data management and analysis. deaths associated with scarlet fever or other gas infections were identified by text mining from causes of death with keywords of traditional chinese ‘scarlet fever’, ‘group a streptococcus’ or ‘toxic shock syndrome’ (3). results from january 2006 to september 2007, the monthly opd data with icd-9-cm code 034.1 from bnhi showed strong correlation with tcdc’s notifiable disease data (r=0.89, p<0.0001). from july 6, 2008 (week 28) through july 28, 2012 (week 30), the average weekly numbers of scarlet fever visits to the opd, er and hospital admissions were 37 (range 11–70), 7 (range 0–20) and 3 (range 0–9). eighty-five percent of the scarlet fever patients were less than 10 years old. in taiwan, scarlet fever occurred year-round with seasonal peaks between may and july (fig. 1). from january 2008 to july 2012, we identified 12 potential patients (9 males, age range 0–82 years) who died of gas infections. no report had listed ‘scarlet fever’ as cause of death during the study period. conclusions taiwan has established an integrated syndromic surveillance system to timely monitor scarlet fever and gas infection associated mortalities since july 2011. syndromic surveillance of scarlet fever through bnhi correlated with number of scarlet fever cases through notifiable disease reporting system. text mining from cause of death with the used keywords may have low sensitivities to identify patients who died of gas infection. in taiwan, syndromic surveillance has also been applied to other diseases such as enterovirus, influenzalike illness, and acute diarrhea. interagency collaborations add values to existing health data in the government and have strengthened tcdc’s capacity of disease surveillance. fig. 1. weekly numbers of nationwide scarlet fever opd and er visits, and hospital admissions, with baseline opd visits and 95% confidence interval calculated by a serfling’s model, week 28 of 2008 to week 30 of 2012. keywords syndromic surveillance; taiwan; scarlet fever; claims data acknowledgments we thank the bureau of national health insurance and office of statistics of department of health for providing data required for this study. references 1.hsieh yc, huang yc. scarlet fever outbreak in hong kong, 2011. j microbiol immunol infect. 2011;44:409-11. 2.tse h, bao jy, davies mr, et al. molecular characterization of the 2011 hong kong scarlet fever outbreak. j infect dis. 2012;206:341-51. 3.chen pj, wu wj, huang wt, chuang jh. an early warning system for pneumonia and influenza mortality in taiwan. emerging health threats journal 2011;4: 11024. *wan-jen wu e-mail: teatea@cdc.gov.tw online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e160, 2013 improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya aliza monroe-wise1, john kinuthia2, sherrilynne fuller3, matthew dunbar4, david masuda5, elisha opiyo6, betty muchai1, christopher chepken6, elijah omwenga6, robert oboko6, alfred osoti2, daniel masys5, michael h. chung 1 1departments of global health and medicine, university of washington 2department of obstetrics and gynaecology, university of nairobi, nairobi, kenya 3department of biomedical informatics and information school, university of washington 4center for studies in demography and ecology, university of washington 5department of biomedical informatics and medical education, university of washington 6school of computing and informatics, university of nairobi abstract objectives information and communication technology (ict) tools are increasingly important for clinical care and international research. many technologies would be particularly useful for healthcare workers in resource-limited settings; however, these individuals are the least likely to utilize ict tools due to lack of knowledge and skills necessary to use them. our program aimed to train researchers in low-resource settings on using ict tools and to understand how different didactic modalities build knowledge and skills in this area. methods we conducted a tiered, blended learning program for researchers in kenya on three areas of ict: geographic information systems, data management, and communication tools. each course included three tiers: online courses, skills workshops, and mentored projects. concurrently, a training of trainers course was taught to ensure sustainable ongoing training. a mixed qualitative and quantitative survey was conducted at the end of each training to assess knowledge and skill acquisition. results course elements that incorporated local examples and hands-on skill building activities were most valuable. discussion boards were sometimes distracting, depending on multiple factors. mentored projects were most useful when there were clear expectations, pre-existing projects, and clear timelines. discussion training in the use of ict tools is highly valued among researchers in low-income settings, particularly when it includes hands-on skill-building and local examples. improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi 1. introduction information and communication technology (ict) tools have transformed the ways in which research and healthcare are conducted and data is managed, becoming integral components of both biomedical research and healthcare delivery throughout the world [1-3]. these technologies can change the ways in which medical data is collected and managed for clinical trials by using mobile devices [4], providers communicate with patients for monitoring health and disease [5], and the creation of large interoperable data management systems for analysis across multiple platforms and studies [6]. many of these ict tools are accessible and freely available on the internet or as open source software [3,7]. while innovative ict practices would have the highest impact on health research and patient care in resource-limited settings [8], these areas often have the lowest ict uptake and utilization rates of anywhere in the world [9,10]. lack of knowledge and skills have been identified as primary barriers to the use of ict tools among health researchers in resource-limited settings [10-12], and there is an increasingly recognized need for improved access to ict training opportunities for health researchers worldwide. it is clear that international collaboration is vitally important for building research capacity in resource limited academic centers [13], and also clear that ict tools can improve the efficiency of multinational research projects that span cultures, languages and time zones [14,15]. as such, international collaborations may both facilitate training surrounding the use and integration of ict tools and also support the research resulting from increased utilization of the tools [16,17]. in kenya, while certain research projects have successfully been implemented in recent years using select ict tools [18,19], a great need exists to increase knowledge and understanding of new technologies in order to expand utilization [20,21], similar to other resource-limited settings. in response to the identified need for improved and expanded training programs in ict utilization for our students demonstrated acquisition of new skills and felt these skills to be valuable in their workplaces. conclusions further training in ict skills for researchers should be considered in other low-resource settings using our program as a foundational model.key words: information and communication technology (ict), blended learning, kenya, e-learning corresponding author: aliza monroe-wise, md, msc. email: alizamw@uw.edu university of washington, 325 ninth avenue, box 359909, seattle, wa 98104-2499 doi: 10.5210/ojphi.v11i3.10323 copyright ©2019 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi health research in kenya, the university of washington (uw) partnered with the university of nairobi (uon) to develop a training program to meet the needs of local researchers in nairobi. we also aimed to gain a deeper understanding of which modalities of ict training were most and least valuable to the facilitation of applied learning in this setting through post-training survey data collection. this paper describes the design and content of our training program, and the evaluation of post-training survey data describing trainees’ views on how various training components fostered the development of ict knowledge and skills. 2. materials and methods leading faculty from uw and uon in the areas of computing, biomedical informatics, geographic information systems, and e-learning convened in january 2015 to collaboratively identify target areas for training and appropriate and effective teaching methods to deliver content. they drew on existing research on the use of ict in biomedical research, experience with effective delivery platforms, and adult learning theory to inform the development of both course content and delivery, and they took several factors into consideration. first, given the importance of international collaboration, the inclusion of international faculty as lecturers in the program was prioritized. given increasing evidence supporting the efficacy of e-learning modalities for distance training [22,23], an e-learning component was included in order to deliver content from international experts in a financially sustainable manner. finally, faculty identified a need to include skills transfer and mastery, in addition to knowledge delivery. studies have shown that blended learning, in which online content is combined with in-person training, is most effective for educational programs that focus on the development of skills [24]; therefore a blended learning approach was taken with an online course featuring international experts followed by mentored, in-person learning. the faculty designed a three-tiered, blended learning program (figure 1). three separate tracks of training were chosen to correspond to areas of highest need and interest: geographic information systems (gis), principles and practice of research data management (ppr), and research management and communication tools (rct). for each of these training tracks, three tiers of training were offered. the first tier was an online course consisting of a series of 4-6 lectures (in voice over powerpoint format), in conjunction with other educational materials, homework and assignments. tier 1 target enrollment was 100 students per course. tier 2 consisted of hands-on workshops for each topic that took place over 5 days after the completion of online courses. participants were selected from those who had completed and passed the online course for each topic. tier 2 workshop target enrollment was 30 students per workshop. finally, the top 15 students from each workshop were identified based on scores from final presentations. these top 15 were then invited to participate in tier 3 for each topic, intensive mentored projects. mentors were chosen from university of nairobi ict experts in each topic, and the mentorship experience lasted 3 months. mentors met with students regularly and guided students through the application of an ict tool to a research project. students were tasked with presenting their projects via either an oral presentation online or at the university of nairobi std/aids collaborative group conference held in nairobi annually. the entire 3-tier training took place over a 6-month timeframe (figure 2). improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi figure 1. overall training structure figure 2. training timeframe a training of trainers (tot) course was simultaneously offered to all faculty and staff at uon who provide ict support and training. this course was led by ict specialists from both uw and uon, and comprised an initial introductory online course that also served as an introduction for the other courses followed by a 5-day hands-on workshop. participants learned how to: help researchers improve their research design and analysis using ict; mentor researchers constructively in their projects; and teach researchers to give effective oral presentations. post-course surveys were offered to participants in each element of this training program. surveys were conducted electronically for online courses, and on paper for in-person workshops and mentoring. surveys comprised both quantitative and qualitative questions covering topics about length of time participants took for the training program, which elements of the course or program were most valuable and least valuable, and whether and how the participants’ knowledge and skills were improved from what they learned in the course. surveys also assessed whether participants felt they could use the knowledge and skills acquired in their workplaces. programmatic data was also collected in the evaluation, including data on course enrollments, course completion, pass rates for each course, and deliverables expected and produced for each course as supporting information to describe skill acquisition. improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi 2.1 course content 2.1.1 introduction to ict in health research (intro) and training of trainers (tot) the goal of the intro course was twofold: first, to provide foundational knowledge to a cadre of faculty and staff who could ensure sustainability and extensibility of the training program and as a resource for ict applications in health research; second, to provide a common introduction to concepts for students in the other three courses. detailed information about objectives and activities for all four courses can be found in appendix a. the core online intro course considered the state of the art data management tools for ensuring reliable collection, aggregation, back-up, analysis, reporting and archiving of data in useful ways. a unique focus of the course was assessing the ability of tools to work together to successfully ensure smooth movement of data and findings from one tool to the next. another focus of the course was evaluation of health research studies to identify those which successfully (or unsuccessfully – thus covering the research pitfalls) incorporate ict in resource-limited settings. because ict changes so rapidly, the course also covered how to remain informed of emerging ict approaches and also how to successfully plan for adaptation to future technology changes. for faculty and staff already familiar with ict, the course provided an introduction to the needs of health researchers and the issues that they face in conducting clinical trials or medical investigations research. the use and research applications of social technologies including crowdsourcing and social media was a particular focus of the course. the online course was followed by a five-day in-person workshop for faculty in the training the trainers (tot) course. the workshop allowed participants to apply their learning from the online course in a hands-on laboratory setting, and provided an opportunity for ict experts and health researchers to meet each other and teach each other the reciprocal skills of ict and health research as well as to collaborate to design new solutions to research challenges. teaching assistants for the other 3 courses were chosen from this tot course. 2.1.2 geographic information systems (gis) the foundation of this course introduced participants to key features of the discipline of geography, and explored how geospatial technologies, such as gis, are commonly used to incorporate spatial theory, analysis, and visualization into health research. the remaining majority of the course was focused on the following objectives: learning how to assess the use of gis in research, performing basic mapping and analysis using open-source gis software, and developing and implementing spatial research questions using gis. this course attempted to teach both the theory to understand how gis is used in research (weekly lectures), and the technical software skills necessary to implement a subset of those concepts (weekly assignments). the workshop component of the gis course focused on expanding the practical technical skills of the participants, while concurrently deepening their understand of geographic science. four workshop modules (mapping, analysis, data manipulation, and rasters) provided practical training to advance the participants competence in qgis from the introductory level in the online course to an intermediate skill level. improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi 2.1.3 principles and practice of research data management (ppr) the ppr course was anchored by three conceptual areas that are converging worldwide in research that involves human volunteer participants. the first of these are the international good clinical practice (gcp) standards developed by the international council for harmonisation of technical requirements for pharmaceuticals for human use [25]. gcp standards have become the accepted global guidelines for ensuring ethical treatment of research participants and creation of research records that are of high quality and amenable to audit for scientific integrity. the second theme of the ppr course was knowledge of data modeling, database design, and data management technologies capable of supporting research ranging from simple single investigator studies to international multisite clinical trials. the third theme was understanding the strengths and hazards of using the internet to acquire and manage research data, with a focus on principles and practice of information security. the independent study assignment for the course required students to bring these related sets of knowledge and skills together to create a research data management plan, including budget, that could become part of a research study proposal to a sponsoring organization. 2.1.4 research management and communication tools (rct) the course was informed by the centrality of the internet as a tool in the research process enabling researchers to access funding, identify collaborative partners, keep abreast with advances in research, and disseminate their research findings quickly and effectively. skills-based learning objectives are outlined in table 1. the course focused on open access ict tools that researchers can creatively leverage in tandem to better manage the different stages of the research process, from proposal writing through to research dissemination and uptake. a key focus of the course was hands-on practice on various research indexing tools, bibliography management tools, research networking tools and platforms, online collaborative tools, social media platforms, data sharing tools and platforms, data back-up and archival tools and platforms, presentation tools, and low-cost communication tools. effective use of a variety of search engines to enhance retrieval of relevant research findings was threaded throughout the course. students benefitted greatly from demonstrations of tools and technologies by their peers. finally, the course equipped learners with strategies for creating an effective, online personal brand to enhance their global visibility, extend their research dissemination audience, and increase the uptake potential of their research. 3.course evaluation results 3.1 overall participation rates & general feedback a total of 978 individuals applied to take the four online courses (table 2). acceptance into courses was based on educational level (high school certificate or higher) and country of residence. pass rates ranged from 42% for the rct course to 100% for the tot course and workshops. the low pass rate for the rct course was due to the required discussion board participation and difficulty level of the material. finally, the 27 students who participated in three-month mentored projects were tasked with producing a deliverable at the end of the training period. overall, 23 of the 27 improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi enrolled successfully submitted deliverables, producing a pass rate of 85% for the mentored projects. online courses and workshops were generally well-received in terms of the timing and pace, organization, and overall effectiveness of the courses. the majority of learners spent between 2 and 6 hours per week on online courses. students occasionally encountered technical challenges, particularly during the online courses. about 15% of respondents in both the gis and rct online courses reported having some technical difficulties accessing materials, the most common of which were due to slow internet limiting access to lectures or difficulty logging in to course content. the most commonly cited elements that posed a distraction to learning in the online courses were discussion boards and technical difficulties. other occasionally cited distractions included problems with learning the content, format of the content (i.e the way in which content was presented), and having too much ancillary content presented in the form of links or additional readings. table 2. acceptance, completion and pass rates for each course training of trainers (tot) geographic information systems (gis) principles & practice of research data management (ppr) research management & communication tools (rct) totals online course total applicants 47 150 397 384 978 participants1 34 (72%) 132 (88%) 241 (61%) 319 (83%) 726 (74%) completed2 32 (94%) 107 (81%) 188 (78%) 232 (73%) 559 (77%) passed3 32 (100%) 84 (78%) 155 (82%) 98 (42%) 369 (66%) workshops total applicants 32 61 87 41 221 participants1 32 (100%) 28 (46%) 30 (34%) 29 (71%) 119 (54%) completed2 32 (100%) 28 (100%) 30 (100%) 29 (100%) 119 (100%) mentored projects participants n/a 10 7 10 27 completed 6 (60%) 7 (100%) 10 (100%) 23 (85%) 1percentage accepted for each course out of total applicants improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi 2percentage who completed course assignments out of total number registered 3percentage who passed the course out of total who completed figure 4. valuable components of online courses figure 5. valuable components of workshops 3.3 online courses while online courses generally received high scores in course evaluations, the most valuable components of these courses varied greatly between the different tracks (figure 4). lectures were considered greatly valuable for the training of trainers (tot) course, whereas assignments were considered the most valuable component of the geographic information systems (gis) course. in general, online courses with active learning components (gis and ppr) were considered especially improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi valuable. gis included weekly activity assignments in which learners were tasked with locating and utilizing mapping resources available on the internet to design, interpret or modify maps. these exercises were widely lauded as being extremely valuable to the learning process. similarly, the ppr course included an independent project which was one of the highlights of the course. conversely, the rct course did not include any practical component, and this was noted by several respondents in the course evaluations with comments such as “increase practical application,” and include “guided practice of the tools.” with the lowest pass rate of the online courses, the rct course was notable in its use of mandatory discussion board assignments rather than active learning components, which may have hindered learning efficacy. one of the well-received assignments in the ppr course utilized published clinical research studies from kenyan researchers to understand the research methods and review the ict methods and tools that were used in the study as well as to identify what additional ict tools and methods might have been used. linking actual kenyan research studies to use of ict tools and technologies proved very effective as a practical teaching aid. similarly, throughout the ppr course, the students successfully partnered with others who had complementary skills, pairing those who had experience in research methods and ict with those who did not. those with clinical research experience could give examples of their own research experience and challenges as it related to the use of specific ict tools they were learning about. discussion boards received mixed reviews from students in the different courses. some felt that the discussion boards were quite a valuable addition to the other components of the course, while others ranked discussion boards as the most distracting feature of the course. supervision and structure in discussion board interactions added more value to this component of the different courses. 3.4 workshops workshops were very well received, earning higher average overall scores than either the online courses or the mentored projects. similar to online courses, the most valuable elements of each workshop differed greatly (figure 5). while practical skills acquired during workshops were among the most highly valued element by participants in the gis and rct workshops, the interactive nature of the tot workshop was its most valued component and the active learning assignments were the highlight of the ppr workshop. lectures and theory were the lowest rated component of all four workshops. specific skills learned that were mentioned frequently were working with shape and raster files, accessing online data and utilizing data for map creation, using plug-ins for spatial analysis, and vector analysis in gis; how to collect high quality data, maintain data accuracy, set up and configure servers, ensure data security using encryption, and programming odk and redcap in ppr; and mind maps, data sharing and management tools, project management and collaboration tools, conceptual framework formulation and referencing tools in rct. workshops also increased exposure to tools the students had never before heard of, broadening their understanding of the vast array of ict applications available. students largely felt that the workshops should have been longer, as there were additional skills and tools they had hoped to master. one limitation of the improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi workshops mentioned by several participants was that android devices were not provided, but were necessary for some of the exercises. 3.5 mentored projects overall, mentored projects received mixed reviews with lower average scores than the other two components of the training. while the value of the mentorship experience was felt to be immense when mentorship was carried out in an ideal manner, there were many obstacles to successful engagement in mentored projects. a common pitfall described in all three courses was lack of clarity in expectations for the program and for completion of the project, with around 40-50% of students stating that expectations were clear in both ppr and gis. each mentee was required to produce a deliverable by the end of the mentorship period. in the gis course, students submitted abstracts with maps that showcased their use of gis concepts and technology. for ppr, mentees sent evidence of forms they had designed to collect data, in the form of either screenshots or downloadable odk forms. in the rct course mentees demonstrated the use of three different tools that were discussed in the workshop by submitting screenshots of engagement with the tools. despite these goals, mentees did not feel well informed regarding mentored project expectations. in the gis mentored projects, the lack of clarity on project deliverables may have contributed to the low pass rate of 60%. having timelines for project completion was mentioned as one way to improve expectations in several of the courses. another frequently cited obstacle was difficulty engaging with mentors, due to lack of mentor’s available time or failure to establish a clear schedule for meetings. one participant recommended that mentor-mentee meetings be mandatory at regular intervals to ensure adequate meeting frequency. another suggestion was to include meetings with other trainees to add a peer mentoring component. finally, similarly to the workshops, some participants mentioned that it was problematic when students were required to produce their own project ideas with supporting data, as several of the students did not have data readily available and suggested that the mentors have data for use in the mentorship projects. overall when the mentored projects went well, they were considered extremely useful. one participant in the rct mentorship project raved “this was a wonderful opportunity that changed my academic life, research work, and approaches for the better of my future career in research.” 4. discussion while information and communication technology (ict) has become integral to the successful implementation of research and health delivery worldwide, there remains a gap in the utilization of these tools among researchers in resource-limited settings, largely due to the lack of education and training programs available. drawing on an international collaboration to expand expertise and reinforce the importance of global collaborations in research, we designed and conducted a group of tiered, blended learning courses focused on training kenyan researchers in the use of ict tools. we collected data from our post-course evaluation surveys to better understand how different didactic modalities functioned to deliver both content and skills in ict. improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi previous programs aimed at providing ict training to audiences in low-resource settings are limited, but highlight the importance of relevance of the concepts taught to the participants’ work [26]. our program affirmed the need for relevance, with highly rated activities being those that incorporated local examples or skills that could be easily applied to everyday work. many of the most highly valued content elements taught in all of the courses were those that focused on how to use specific tools, such as redcap, odk, mendeley, and google tools. we found the tiered training program to be useful, although both the online course and the mentorship components were subject to pitfalls. technical and infrastructure challenges are common barriers to implementing e-learning programs [27,28] but might be overcome through stakeholder and institutional support [27]. although several studies have highlighted the utility of discussion boards [29,30] and they are generally considered to be productive components of online learning [31], they have been noted to be problematic before [30,32], largely due to lack of perceived need and unfamiliarity with the technology. our program data demonstrated that discussion boards were most useful when provided in a structured manner, with instructors regularly logging in and monitoring the interactions taking place, echoing previous research showing that the type and frequency of instructor interaction in online discussion boards is vital to their didactic success [31]. while mentorship has been shown to positively affect mentees’ career choices and development [33], pitfalls can be common [34,35]. mentored projects in our training were subject to many of these obstacles, and were most useful when projects and data were available at the start of the project, mentors had sufficient time to provide considerable effort and oversight, and when expectations, timelines and deadlines were made clear at the beginning of the project period. finally, previous studies have emphasized the workshop format as an ideal modality for delivering skills-based training in low-resource settings, particularly in the realm of ict [36]. our evaluation results underscore this finding, with the workshops succeeding in delivering both knowledge and skills without the obstacles that are commonly encountered in e-learning formats and during mentorship. the interpretation of data from this study is subject to several potential limitations. first, our surveys all relied on self-reported measures, which can be influenced by desirability and recall biases, among others. we mitigated these issues by conducting surveys immediately following trainings, and by using normalizing language where possible. additionally, we have triangulated self-reported data with more objective measures, such as pass rates and deliverables produced for each course. second, outcomes from our training programs may not be applicable to other lowresource settings in africa or elsewhere. while trainings must be tailored to their specific audience and setting, we believe that the core concepts and structure of our ict courses can be applied broadly. as training in ict becomes more important for researchers worldwide, the need for effective educational modalities to provide knowledge and skills to researchers in resource-limited settings is increasingly apparent. our training program may serve as an excellent foundation on which future courses in ict may be based. additionally, the inclusion of the tot course contributes significantly to the didactic sustainability of the course content, and may become the basis of similar, locally-offered courses in the future. improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi authors’ contributions mc, jk and eo conceived of the project. mc, jk, eo, bm, sf, md, dm, cc, eo, ro, ao and dm implemented the training or designed and taught courses in the training program. amw, mc, bm and jk analyzed the data. amw, dm, sf and mc wrote the manuscript and all authors reviewed the manuscript for content. acknowledgements the authors wish to thank the students and faculty at the university of nairobi for their participation in this training activity. funding this training was funded by nih grant 1r25tw009692. the funding agency did not play a role in the research design, data collection, data analysis or interpretation. ethical approval the collection of data for this study was approved the kenyatta national hospital ethics and research committee and was deemed exempt by the university of washington division of human subjects. competing interests the authors state that they have no competing interests. references 1. friedman dj, parrish rg, ross da. 2013. electronic health records and us public health: current realities and future promise. am j public health wash. 103(9), 1560-67. pubmed https://doi.org/10.2105/ajph.2013.301220 2. institute of medicine. digital infrastructure workshop highlights [internet]. 2011 [cited 2018 aug 16]. available from: http://www.nationalacademies.org.offcampus.lib.washington.edu/hmd/~/media/files/report %20files/2010/digital-infrastructure-for-the-learning-healthsystem/digital%20infrastructure%20workshop%20highlights.pdf 3. fuller s. 2010. tracking the global express: new tools addressing disease threats across the world. epidemiology. 21(6), 769-71. pubmed https://doi.org/10.1097/ede.0b013e3181f56757 4. zhang j, sun l, liu y, wang h, sun n, et al. 2017. mobile device-based electronic data capture system used in a clinical randomized controlled trial: advantages and challenges. j med internet res. 19(3), e66. pubmed https://doi.org/10.2196/jmir.6978 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23865646&dopt=abstract https://doi.org/10.2105/ajph.2013.301220 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20924231&dopt=abstract https://doi.org/10.1097/ede.0b013e3181f56757 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28274907&dopt=abstract https://doi.org/10.2196/jmir.6978 improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi 5. mhealth technology use and implications in historically underserved and minority populations in the united states: systematic literature review [internet]. [cited 2018 aug 16]. available from: https://www-ncbi-nlm-nihgov.offcampus.lib.washington.edu/pmc/articles/pmc6028762/#ref10 6. fischer ba, zigmond mj. 2010. the essential nature of sharing in science. sci eng ethics. 16(4), 783-99. pubmed https://doi.org/10.1007/s11948-010-9239-x 7. bandyopadhyay s. 2016. s. s. ict in education: open source software and its impact on teachers and students. int j comput appl. 151(6), 19-24. 8. wenger ec, snyder wm. communities of practice: the organizational frontier [internet]. harvard business review. 2000 [cited 2018 aug 16]. available from: https://hbr.org/2000/01/communities-of-practice-the-organizational-frontier 9. lang t. 2011. advancing global health research through digital technology and sharing data. science. 331(6018), 714-17. pubmed https://doi.org/10.1126/science.1199349 10. wang j, abdullah as, ma z, fu h, huang k, et al. 2017. building capacity for information and communication technology use in global health research and training in china: a qualitative study among chinese health sciences faculty members. health res policy syst. 15(1), 59. pubmed https://doi.org/10.1186/s12961-017-0222-8 11. ward jp, gordon j, field mj, lehmann hp. 2001. communication and information technology in medical education. lancet. 357(9258), 792-96. pubmed https://doi.org/10.1016/s0140-6736(00)04173-8 12. mclellan f. 2001. information technology can benefit developing countries. lancet. 358(9278), 308. pubmed https://doi.org/10.1016/s0140-6736(01)05534-9 13. conalogue d, kinn s, mulligan j-a, mcneil m. 2017. international consultation on longterm global health research priorities, research capacity and research uptake in developing countries. health res policy syst. 15(1), 24. pubmed https://doi.org/10.1186/s12961-0170181-0 14. hoffman dm, blasi b, ćulum b, dragšić ž, ewen a, et al. 2014. the methodological illumination of a blind spot: information and communication technology and international research team dynamics in a higher education research program. high educ. 67(4), 473-95. https://doi.org/10.1007/s10734-013-9692-y 15. moreau m, asana l, ngwa w. information and communication technologies elide spatial and temporal distances to usher in a new era of global health collaborations. proc am soc radiat oncol 57th annu meet. 2015 nov 1;93(3, supplement):e382–3. https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21108019&dopt=abstract https://doi.org/10.1007/s11948-010-9239-x https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21311011&dopt=abstract https://doi.org/10.1126/science.1199349 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28659155&dopt=abstract https://doi.org/10.1186/s12961-017-0222-8 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11253986&dopt=abstract https://doi.org/10.1016/s0140-6736(00)04173-8 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11498233&dopt=abstract https://doi.org/10.1016/s0140-6736(01)05534-9 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28327164&dopt=abstract https://doi.org/10.1186/s12961-017-0181-0 https://doi.org/10.1186/s12961-017-0181-0 https://doi.org/10.1007/s10734-013-9692-y improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi 16. kimball am, curioso wh, arima y, fuller s, garcia pj, et al. 2009. developing capacity in health informatics in a resource poor setting: lessons from peru. hum resour health. 7(1), 80. pubmed https://doi.org/10.1186/1478-4491-7-80 17. curioso wh, fuller s, garcia pj, holmes kk, kimball am. 2010. ten years of international collaboration in biomedical informatics and beyond: the amauta program in peru. j am med inform assoc. 17(4), 477-80. pubmed https://doi.org/10.1136/jamia.2009.002196 18. ojwang’ jk, lee vc, waruru a, ssempijja v, ng’ang’a jg, wakhutu be, et al. using information and communications technology in a national population-based survey: the kenya aids indicator survey 2012. j acquir immune defic syndr 1999. 2014 may 1;66 suppl 1:s123-129. 19. waruru a, achia tno, tobias jl, ngʼangʼa j, mwangi m, wamicwe j, et al. finding hidden hiv clusters to support geographic-oriented hiv interventions in kenya. j acquir immune defic syndr 1999. 2018 jun 1;78(2):144–54. 20. juma c, sundsmo a, maket b, powell r, aluoch g. 2015. using information communication technologies to increase the institutional capacity of local health organisations in africa: a case study of the kenya civil society portal for health. pan afr med j. 21, 23. pubmed https://doi.org/10.11604/pamj.2015.21.23.5130 21. wekesa m. 2015. challenges in regulation of biomedical research: the case of kenya. niger j clin pract. 18(suppl), s25-30. pubmed https://doi.org/10.4103/1119-3077.170819 22. ruiz jg, mintzer mj, leipzig rm. 2006. the impact of e-learning in medical education. acad med j assoc am med coll. 81(3), 207-12. pubmed https://doi.org/10.1097/00001888200603000-00002 23. sinclair pm, kable a, levett-jones t, booth d. 2016. the effectiveness of internet-based elearning on clinician behaviour and patient outcomes: a systematic review. int j nurs stud. 57, 70-81. pubmed https://doi.org/10.1016/j.ijnurstu.2016.01.011 24. munro v, morello a, oster c, redmond c, vnuk a, et al. 2018. e-learning for selfmanagement support: introducing blended learning for graduate students a cohort study. bmc med educ. 18(1), 219. pubmed https://doi.org/10.1186/s12909-018-1328-6 25. abraham j. international conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. in: brouder a, tietje c, editors. handbook of transnational economic governance regimes [internet]. brill; 2009 [cited 2018 dec 3]. p. 1041–54. available from: http://booksandjournals.brillonline.com/content/books/10.1163/ej.9789004163300.i1081.897 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19860918&dopt=abstract https://doi.org/10.1186/1478-4491-7-80 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20595317&dopt=abstract https://doi.org/10.1136/jamia.2009.002196 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26401217&dopt=abstract https://doi.org/10.11604/pamj.2015.21.23.5130 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26620619&dopt=abstract https://doi.org/10.4103/1119-3077.170819 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16501260&dopt=abstract https://doi.org/10.1097/00001888-200603000-00002 https://doi.org/10.1097/00001888-200603000-00002 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27045566&dopt=abstract https://doi.org/10.1016/j.ijnurstu.2016.01.011 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30249238&dopt=abstract https://doi.org/10.1186/s12909-018-1328-6 improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi 26. lucas ri, promentilla ma, ubando a, tan rg, aviso k, et al. 2017. an ahp-based evaluation method for teacher training workshop on information and communication technology. eval program plann. 63, 93-100. pubmed https://doi.org/10.1016/j.evalprogplan.2017.04.002 27. bediang g, stoll b, geissbuhler a, klohn am, stuckelberger a, et al. 2013. computer literacy and e-learning perception in cameroon: the case of yaounde faculty of medicine and biomedical sciences. bmc med educ. 13, 57. pubmed https://doi.org/10.1186/14726920-13-57 28. o’doherty d, dromey m, lougheed j, hannigan a, last j, et al. barriers and solutions to online learning in medical education – an integrative review. bmc med educ [internet]. 2018 [cited 2019 jul 8];18. available from: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5992716/ 29. donlan p. 2019. use of the online discussion board in health professions education: contributions, challenges, and considerations. j contin educ health prof. 39(2), 124-29. pubmed https://doi.org/10.1097/ceh.0000000000000252 30. feldacker c, jacob s, chung mh, nartker a, kim hn. experiences and perceptions of online continuing professional development among clinicians in sub-saharan africa. hum resour health. 2017 29;15(1):89. 31. osborne dm, byrne jh, massey dl, johnston anb. 2018. use of online asynchronous discussion boards to engage students, enhance critical thinking, and foster staffstudent/student-student collaboration: a mixed method study. nurse educ today. 70, 40-46. pubmed https://doi.org/10.1016/j.nedt.2018.08.014 32. steinert y, mcleod pj, conochie l, nasmith l. 2002. an online discussion for medical faculty: an experiment that failed. acad med j assoc am med coll. 77(9), 939-40. pubmed https://doi.org/10.1097/00001888-200209000-00046 33. sambunjak d, straus se, marušić a. 2006. mentoring in academic medicine: a systematic review. jama. 296(9), 1103-15. pubmed https://doi.org/10.1001/jama.296.9.1103 34. barker er. 2006. mentoring--a complex relationship. j am acad nurse pract. 18(2), 56-61. pubmed https://doi.org/10.1111/j.1745-7599.2006.00102.x 35. franzblau le, kotsis sv, chung kc. 2013. mentorship: concepts and application to plastic surgery training programs. plast reconstr surg. 131(5), 837e-43e. pubmed https://doi.org/10.1097/prs.0b013e318287a0c9 36. uneke cj, ezeoha ae, uro-chukwu h, ezeonu ct, ogbu o, onwe f, et al. improving nigerian health policymakers’ capacity to access and utilize policy relevant evidence: outcome of information and communication technology training workshop. pan afr med j https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28445801&dopt=abstract https://doi.org/10.1016/j.evalprogplan.2017.04.002 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23601853&dopt=abstract https://doi.org/10.1186/1472-6920-13-57 https://doi.org/10.1186/1472-6920-13-57 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30998568&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30998568&dopt=abstract https://doi.org/10.1097/ceh.0000000000000252 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30145533&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30145533&dopt=abstract https://doi.org/10.1016/j.nedt.2018.08.014 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=12228112&dopt=abstract https://doi.org/10.1097/00001888-200209000-00046 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16954490&dopt=abstract https://doi.org/10.1001/jama.296.9.1103 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16460411&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16460411&dopt=abstract https://doi.org/10.1111/j.1745-7599.2006.00102.x https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23629123&dopt=abstract https://doi.org/10.1097/prs.0b013e318287a0c9 improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi [internet]. 2015 jul 23 [cited 2019 jul 4];21. available from: https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4587084/ appendix a. learning objectives, target skills acquired, and topics covered course title learning objectives target skills topics & activities covered creative integration of ict tools and technologies for enhancing research design, management and implementation (train the trainers module as well as introductory module for the other courses) • understand the role of ict tools in responding to health research challenges • use ict tools to finding and managing the scientific literature; • discuss and use social media • use data visualization tools • apply ict tools in scientific communications • apply research productivity tools • use various mobile technologies and tools • use ict tools for project management. • retrieve relevant research articles from appropriate research databases to support the development of research hypotheses and research proposals. • use a bibliographic management tool (mendeley or similar) to download and management research citations and full-text articles • identify and select relevant mobile technology tools to design and implement a simple research data collection instrument. • use a variety of desktop productivity tools in interactive ways to enhance data analysis and reporting. • use tools and technologies to improve research • the role of ict tools in responding to health research challenges • finding and managing the scientific literature • social media • data visualization • scientific communications • research productivity • mobile technologies and tools • project management https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4587084/ improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi communications including written and oral presentations. • demonstrate creative integration of disparate ict tools to support all phases of the research process. geographic information systems • recognizing the growing significance of spatial analysis and geography for advancing health research • describe how gis can be used to bring together mapping, data management, and geospatial analysis techniques in the context of health research • understand how to use gis as a tool to perform basic quantitative geographic analysis and spatial data visualization (mapping) • recognize the unique challenges of performing quantitative analysis with spatial data • assess the use of gis in the research literature of any knowledge domain/discipline • understand the components of a geographic information system (gis) and how it can be used effectively throughout scientific research • competency using quantum gis (qgis), an open source gis software package, to merge, manipulate, analyze and map spatial data • ability to locate spatial data of the correct type and quality, in order to address a research question • comprehension of basic cartographic design (mapping) skills in order to clearly communicate results to your audience • understand how gis brings together mapping, data management, and • what is geography and gis?: exploring and interpreting web mapping systems • learning about gis software: installing and navigating qgis • gis data types: importing data layers and basic mapping • gis data sources: key resources for spatial data and quality considerations • spatial analysis: working with analysis functions in qgis • cartography: design and formal map layout in qgis • gis research workflows: evaluate the use of basic gis techniques in other’s research improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi • develop and implement spatial research questions using gis geospatial analysis technologies for health research principles & practice of research data management • understand the unique ethical and technical requirements of research involving human participants • know the historical evolution of methods for managing clinical research data • know types of data management software that are appropriate for single site and multicenter research, for studies of varying size and complexity • understand the characteristics of successful research data management operations • know how research data audits are conducted and how to prepare for one • understand methods for ensuring the security and confidentiality of physical and electronic research data • understand the strengths and • managing research data in compliance with international good clinical practice standards • data modeling for design of computerized databases that accommodate sparse data and repeated measures • ability to create processes that result in research data that is accurate, complete, timely, verifiable, secure, and available for analysis • ability to write a complete research data management plan for a clinical research project, including process, people, technology, and budget components • ability to design high quality paper and electronic data capture forms • ability to use two contemporary online data management systems (redcap • what is biomedical informatics, and how does it contribute to effective data management? • principles of observational and interventional research involving human volunteers • characteristics of ‘sensitive’ data, it’s acquisition, storage • what are international good clinical practice standards and why are they important? • planning sequence for designing and implementing a research study and its data management infrastructure • strengths and weaknesses of hierarchical, objectoriented, xml and relational database technologies • data coding standards to maximize utility and re-usability of data • designing data capture forms to improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi hazards of using the internet for acquisition and management of sensitive data and open data kit odk) to design and implement a simple research study maximize usability and data completeness • specialized contemporary electronic data capture technologies, including barcoding, scantron and teleforms. • design and use of smartphone apps for research data management research management & communication tools • describe the skills used in the research process and link with a highlight of the research process steps already covered in previous courses such as data management. • find and use a data set to do basic data analysis focusing on descriptive statistics, and basic parametric tests. • perform data analysis using descriptive statistics and basic parametric tests using an open source data analysis software such as pspp. • describe results dissemination • understand the research process. • demonstrate how to identify data sets. • demonstrate knowledge of descriptive statistics, and basic parametric tests • understand how to use a statistical tool to analyse data to generate results for descriptive statistics, and basic parametric tests • understand how to make oral presentations and write research papers • understand how indexing and web searching and • ict skills used in the research process and link with a highlight of the research process steps already covered in previous courses i.e. introduction to the research process, data management and data visualization • data analysis. identify a data set and guide the trainees on how to do basic data analysis, perhaps focusing on descriptive statistics, and basic parametric tests. this will be done as theory. • data analysis using descriptive statistics improving information and communications technology (ict) knowledge and skills to develop health research capacity in kenya online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e22, 2019 ojphi techniques such as presentations, policy briefs. • describe how research collaboration can occur using linkedin as a tool, and one other tool for collaboration. • demonstrate how indexing and web searching and bibliography is done. bibliography are done. and basic parametric tests using an open source data analysis software such as pspp. the learners should run some designed tests to see some sample results screens displayed, and then they run tests as assignments • results dissemination techniques: presentations, policy briefs, etc • research collaboration, using linkedin as a tool, and one other tool for collaboration • handling of indexing and web searching and bibliography layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts the biosurveillance resource directory a one-stop shop for systems, sources, and tools kristen margevicius*, mac brown, lauren castro, william b. daniel, eric n. generous, kirsten taylor-mccabe and alina deshpande los alamos national laboratory, los alamos, nm, usa objective the goal of this project is to identify systems and data streams relevant for infectious disease biosurveillance. this effort is part of a larger project evaluating existing and potential data streams for use in local, national, and international infectious disease surveillance systems with the intent of developing tools to provide decision-makers with timely information to predict, prepare for, and mitigate the spread of disease. introduction local, national, and global infectious disease surveillance systems have been implemented to meet the demands of monitoring, detecting, and reporting disease outbreaks and prevalence. varying surveillance goals and geographic reach have led to multiple and disparate systems, each using unique combinations of data streams to meet surveillance criteria. in order to assess the utility and effectiveness of different data streams for global disease surveillance, a comprehensive survey of current human, animal, plant, and marine surveillance systems and data streams was undertaken. information regarding surveillance systems and data streams has been (and continues to be) systematically culled from websites, peer-reviewed literature, government documents, and subject-matter expert consultations. methods a relational database has been developed and refined to allow for detailed analyses of data streams and surveillance systems. to maximize the utility of the database and facilitate one-stop-shopping for biosurveillance system information, we have expanded our scope to include not only biosurveillance systems, but also data sources, tools, and biosurveillance collectives. captured in the information collected about the resource (if available) is the name and acronym of the resource, the date the resource became available, the accessibility of the resource (is it open to all, or are there limitations to access), the primary sponsors, if the resource is associated with gis functionality, and if the focus is health. also collected is contact information, information regarding the scope and domain of the resource, the pertinent diseases or disease categories, and the geographic and population coverage of the resource. websites associated with the resource are directly accessible from the database. data stream information is also captured based on our developed data stream framework. if the resource uses other specified systems/sources/tools for data gathering or analysis, then that is also captured and directly linked within the database. results the biosurveillance resource directory (brd) is in the process of being tested by multiple potential end users in the public health, biosecurity, and biosurveillance communities. feedback from these testers is being used to refine the database to maximize functionality and utility. additionally, methods for dynamically updating and maintaining the database are being evaluated. automated and semi-automated queriable reports have been developed and are integral to demonstrating specific use-case scenarios in which the brd would be beneficial for end-users. conclusions a need for a biosurveillance one-stop shop has been increasingly called for to help in evaluating what data streams and systems are available and relevant for many different biosurveillance needs and goals. the prototype biosurveillance resource directory is a searchable, dynamic database for biosurveillance systems, sources, and tools information. keywords infectious disease; biosurveillance; database acknowledgments this project is supported by the chemical and biological technologies directorate joint science and technology office (jsto), defense threat reduction agency (dtra). *kristen margevicius e-mail: kmargevicius@lanl.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e138, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts using the flow of people in cluster detection and inference sabino j. ferreira*1, francisco s. oliveira1, ricardo tavares2 and flavio r. moura2 1federal university of minas gerais, belo horizonte, brazil; 2federal university of ouro preto, ouro preto, brazil objective we present a new approach to the circular scan method [1] that uses the flow of people to detect and infer clusters of regions with high incidence of some event randomly distributed in a map. we use a real database of homicides cases in minas gerais state, in southeast brazil to compare our proposed method with the original circular scan method in a study of simulated clusters and the real situation. introduction the traditional satscan algorithm[1],[2] uses the euclidean distance between centroids of the regions in a map to assemble a connected (in the sense that two connected regions share a physical border) sets of regions. according to the value of the respective logarithm of the likelihood ratio (llr) a connected set of regions can be classified as a statistically significant detected cluster. considering the study of events like contagious diseases or homicides we consider using the flow of people between two regions in order to build up a set of regions (zone) with high incidence of cases of the event. in this sense the regions will be closer as the greater the flow of people between them. in a cluster of regions formed according to the criterion of proximity due to the flow of people, the regions will be not necessarily connected to each other. methods we consider a study map with a number of observed cases and risk population for each region. the original circular scan algorithm randomly chooses one region as the first zone and calculates its respective llr. in the next step a new zone is created including the first region and the region closest to it according the euclidean distance between their centroids and the respective llr is calculated. this process is repeated until the zone population exceeds a certain percentage of the total population of the map. in our spatial flow scan algorithm everything works in the same manner except that the degree of proximity of two regions is given by the flow of people between them, the higher the flow between the regions closest one is the other. instead of considering an order of increasing distances to add a region and create a new zone our algorithm uses a decreasing flow of people. in this way we can obtain a zone/cluster candidate composed of a number of non necessarily connected regions. results minas gerais state is located in brazil south-eastern region composed of 853 municipalities or regions with an estimated population of 19,150,344 in 2005. all data were obtained from the brazilian ministry of health (www.datasus.gov.br ) and brazilian institute of geography and statistics (www.ibge.gov.br). in the period of 2003 to 2008 were recorded 20,912 homicides at a rate of 22 cases per 100,000. to measure the flow of people between the cities we obtain the data of bus round trips between all the 853 minas gerais municipalities from state department of highways (www.der.mg.gov.br ). as a large number of pairs of cities have zero bus trips between them we use a gravity model [3] to estimate the flow of people. we use 30% as upper percentage for a zone population. with the real data of homicides cases the original circular scan found a significant cluster containing the city of belo horizonte which is the minas gerais state capital and large urban area that include belo horizonte and 22 more cities totalizing a population of about 3.5 milion people. our adapted spatial scan algorithm also found a similar cluster including the capital belo horizonte but with two small cities less. conclusions in simulation studies where the real cluster is known we observe that our spatial flow scan algorithm has a performance similar to the circular scan concerning detection power and slightly worse in relation to the positive predicted value (ppv) and the sensitivity when the real cluster is regular. however, the performance of our algorithm is clearly better with regard to the sensitivity and the ppv when the real cluster is irregular and or non-connected. keywords spatial scan statistics; flow of people; spatial flow scan algorithm; gravity models acknowledgments sjf acknowledges the support by fapemig, mg, brazil. references [1] kulldorff m. a spatial scan statistic, comm. statist. theory meth., 1997, 26(6), 1481-1496. [2] kulldorff m. satscan: software for the spatial, tem-poral and spacetime scan statistics. [www.satscan.org]. [3] signorino g.; pasetto r.; gatto e.; mucciardi m.; rocca m. la; muso p. gravity models to classify commuting vs. resident workers. an application to the analysis of residential risk in a contaminated area. . int. j. of health geographics, 2011. 10:11, pp. 1-10. *sabino j. ferreira e-mail: sabjfn@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e12, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts implementation of a mobile-based surveillance system in saudi arabia for the 2009 hajj wei li* centers for disease control and prevention, atlanta, ga, usa objective to develop and implement a mobile-based disease surveillance system in the kingdom of saudi arabia (ksa) for the 2009 hajj; to strengthen public health preparedness for the h1n1 influenza a pandemic. introduction the hajj is considered to be the largest mass gathering to date, attracting an estimated 2.5 million muslims from more than 160 countries annually (1). the h1n1 influenza a pandemic of 2009 generated a global wave of concern among public health departments that resulted in the institution of preventive measures to limit transmission of the disease. meanwhile, the pandemic amplified an urgent need for more innovative disease surveillance tools to combat disease outbreaks. a collaborative effort between the ksa ministry of health (moh) and the u.s. centers for disease control and prevention (cdc) was initiated to implement and deploy an informatics-based mobile solution to provide early detection and reporting of disease outbreaks during the 2009 hajj. the mobile-based tool aimed to improve the efficiency of disease case reporting, recognize potential outbreaks, and enhance the moh’s operational effectiveness in deploying resources (2). methods we designed a case-based system consisting of a mobile-based data collection toolkit and interactive map-based user interface to perform geospatial analysis and visualization. a train-the-trainer approach was adapted to provide training to the ksa moh. results more than 200 public health and information and communication technology (ict) professionals were trained, and 100 mobile devices were deployed during the 2009 hajj. nine diseases and conditions that were considered as highest priority during the hajj were under surveillance, including h1n1 influenza a and influenza-like illness. pilot testing of the system was conducted during the first week of ramadan and a modified system was fully operational during the hajj. data collected on smartphones were sent to the system via a secured network. the data were processed immediately and visualized on highly interactive maps with local and global views. conclusions effective public health decision-making requires timely and accurate information from a variety of sources. mobile-based systems (e.g., personal digital assistants and smartphones) for data collection, transmission, reporting, and analyses provide a faster, easier, and cheaper means to communicate standardized and shareable public health data for decision-making (3). mobile-based systems have been recognized as a quick and effective response solution to mass gatherings and recommended as data gathering and communication systems with geographical information system (gis) capability (2). this paper explored the development and implementation of the global positioning system/ geographic information system (gps/gis) enabled mobile-based disease surveillance system as a feasible and effective way to support and strengthen preparedness for h1n1 influenza a during the 2009 hajj. mobile computing technology can be utilized to provide rapid and accurate data collection for public health decision-making during mass gatherings. the gis-based interactive mapping tool provided a pioneering example of the power of a geographically based internetaccessible surveillance system with real-time data visualization. the technical challenges in the process of implementation and in the field were also identified. a need now exists for a comprehensive and comparative review of parameters such as handheld device cost, training required, and system evaluations because selecting the appropriate software/hardware and system remains a challenge not only to public health professionals, but to the development and application of informatics technology as well. keywords mobile technology; gis/gps; mass gatherings; surveillance system; public health preparedness acknowledgments many people contributed to the mobile-based surveillance system’s development and implementation for the 2009 hajj. the author would like to acknowledge dr. z. memish and his colleagues at ksa moh, mr. c. gillespie and his colleagues at the u.s. embassy in ksa, the cdc foundation, and colleagues across cdc. references 1. memish za, ahmed ga. mecca bound: the challenges ahead. j. travel med 2002; 9:202-10 2. memish za, mcnabb s, mahoney f, et al. establishment of public health security in saudi arabia for the 2009 hajj in response to pandemic influenza a h1n1. the lancet, published online november 14, 2009; doi:10.1016/s0140-6736(09)61927-9 3. yu, p. et al. the development and evaluation of a pda-based method for public health surveillance data collection in developing countries, int. j. med. inform. (2009; 78(8):532-42 *wei li e-mail: for5@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e137, 2013 crappdf.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 137 (page number not for citation purposes) isds 2013 conference abstracts an early warning surveillance platform for developing countries nsaibirni robert fondze jr*1, 2, gaëtan texier2, 3, patrice tchendjou2, george edouard kouamou1, richard njouom2, maurice demanou2 and maurice tchuente1 1department of computer science, faculty of science, university of yaoundé i, yaoundé, cameroon; 2centre pasteur du cameroun, yaoundé, cameroon; 3umr 912 sesstim inserm/ird/aix-marseille université, marseille, france � �� �� �� � � �� �� �� � objective ������ �� ��� ��� ������ ������ �������� �������� ���������� �� ���� ������� ���� ������� ������ �� ������������� �������� �������� ����� ��������� ���� ����� ������� � ����� � �� � �� �������������� �� ����� ��� �� �� introduction ������ �������� ���������� �� ��!"�� ��� �� #��� �� �� ��� ��� ���� � ������ � � �� ������� � ������������$� �% ������� ����� ���� �� ����� ���� � ��!"���� ����&����� ���� �������������� ���������'������ ��� ���� ������������������� ���������� � �� � �� ������ �� ���� ���� �� ��� � ������������������������ ��(� �) ������!"���� ������#������ ��� � �� �� ����� � � �� � ��������� � ��� ����� ����'������� ����� ��� �������� ��������'�� �� � �� � �� ����&��� ����� �� �������� �) ��� � �� ��� �� ����������*� �� �����������������#��� ����������� �� � ����� �� ���!"���� ������� ���������� �+�� ���������������� � ����������� � ������������������������ ���� �� � ���� �� � � #���� ���� ������� �� ,�� ��� ����� �� ��� � ��� �� ������ ����������� �����*� #����� �� ���� ���� ��� � ��� � �& � ������ ������ �� �� �� ���� methods !���� � ���������������������������������������������������� �� �� �� � ������� ����#������� ���� �����������-����" �� �� � �� �� ����������������������� �� ��� �.�/����� ���� ���� � �� �� � ��� � �� � �*����� ������ ������� �� ���� ����� ��� �� ����� � ��� ����� ��� ��� �� ��� ��� �� ����� ����� ������ �� �� +� ���� � �� / ��� ��+/��� ����� ��0�������� �� ��� � �� � ������������������������ ��� ����� �� ����� ���/��#�����"� ��� ����������� � �� ��� �� ��� 0�����/ �0��� � �� ��� � �� ���� �� ��� ������������ �� ����� �� ����� ���� ����� ��������� ��������*����� ������ ��������� � �� � ��� �� ������������� ������� � � �� � ���'���� ��� �� �� � *���#����� �� ����� � ������� ���"� �� � ��������� � � ��� ����*�������� �� ��� �1��� ������������ ���2���*� #� �� ��� � �� ��� �� �������� ������� �� ���� ���� ���� ������*� #�� ���� ��� ����#�������� ��� results !������� �������� ����� ���� �� ����� �� � ��������� �� ���� �� �������� � � �������� ���3(����3������ ����������� � ������ � �� � / ��� ���� �� ������ ������� �� ���� ����� ��� �� ����� ����� ������� � �������� � ��� �����4�� �� ��� ��+� ���� � �������������� ���� � �� ���+/ ����� � ������ � �� � ���� ������ ���������� ���� �� � �� ���� ��������� ������������� � ���� � *���#������ � ��� ���� ��5� � ��� ��� �� ���� �� ������ ��� � � �� ��� �*��������6 ���������� �� � ����*�������� �� ���.�2������ �7����� �� ���8���"�������7����� � �� ���9��� �&� ��� ������ !���� ��� ) ����� 0�������� ��!)0��:��� ���������� ����"�����;";)����� �� ����$� �/������������ � � �� ���*����� ������� � �� � ������ ���4�� ���� ������� ���� �� � ������ ���� �������������������������� �� ��������� conclusions /������� � ��������������� �� ����*����� ������ �� ��������� ������ �� �� � ���� �� ������ ��� ���������� �������� �� �����&�*��� ��* ��� � ����� ���� �� � �������� ������������ ���� �!� ������� � �����#�� ���� ��� ��� ��� ����� ��� �� �������*��� ����� ��� ���������� ���� � ��� �� ��� ����� ���� �������������������*� # �+ ������ �������� ������ ������ � ��� ��� �������� ���� ���� ��� �������������������������� ������ ��� keywords ������ �������� �������� ���������� �<� ��*�� � ���� �� ��� ��� � �<� �� ��� ������ � acknowledgments /����� �#�������� � ���*�<��4��� �������� ��� � ��%��� ������%����� "���� ��� �� ���;"������ ���+�� � � �4�� ���� ��4������������ ������� � �� � =+5+)0��=�* �� ����+� ���� � �������5� ��� ������+�� ��� �'���� ���� )� �>�� �'���0����'�>���;������� �� ��?� ���>�+ references $ �3 �����2 �= �*��� ��"� ���������"��������� �.�0�4�*�� �%��� ��+�� � ��� � ��0��� � � �3 ���!�����@�" ����+� ��% * #����a���3�����<� ( �4�� ���0� ��������/�������0� ���� �"��������� ��������� � ��'�� �)�� �� ����" ��� ���4�*�� � � ��<�(b$$ � 1 ������� �%��4���������=��c���������/�&����c��d�������&����)������� 3���� � ���3 �0�) ����������0� �� � ����� ��"��� � ����"� �� � ���� ����� �������5����/����"��������� ��"�� ��� �0�������"������� �(bbe� $9(<� 8 �� 4 �2������ ���a 3 �0��������0 �� ������������) �0 ��� �� �� �0� � � �� � ������ �� ���� �� ����������� � � �� �� � *���#�� ������ � ��� �������� �3�5�" � �" �$ff:<98e�g�9:1 � 9 �5 *�� �� �"������� �)� � ���� �� ����� �� � �� � ������������ ���& ���� ����� ���������������� �� �4�*�� �%��� ��5�� � �� �$f:1<� : �= �����0�!! �0���� ������ ���&� ��� ����������� ���� ���������� ���� � � �� ��� �/� �� �� �� �<�$fhh *nsaibirni robert fondze jr e-mail: nsairobby@gmail.com� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e10, 2014 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts usefulness of syndromic surveillance for early outbreak detection in small islands: the case of mayotte pascal vilain*1, olivier maillard3, julien raslan-loubatie2, mohamed ahmed abdou3, tinne lernout2 and laurent filleul1 1regional office of the french institute for public health surveillance of indian ocean, saint-denis, reunion; 2regional office of the french institute for public health surveillance of indian ocean, mamoudzou, mayotte; 3hospital center of mayotte, mamoudzou, mayotte objective to present the usefulness of syndromic surveillance for the detection of infectious diseases outbreak in small islands, based on the experience of mayotte. introduction mayotte island, a french overseas department of around 374 km2 and 200 000 inhabitants is located in the north of mozambique channel in the indian ocean (figure1). in response to the threat of the pandemic influenza a(h1n1)2009 virus emergence, a syndromic surveillance system has been implemented in order to monitor its spread and its impact on public health (1). this surveillance system which proved to be useful during the influenza pandemic, has been maintained in order to detect infection diseases outbreaks. methods data are collected daily directly from patients’ computerized medical files that are filled in during medical consultations at the emergency department (ed) of the hospital center of mayotte (2). among the collected variables, the diagnosis coded according to icd-10 is used to categorize the syndromes. several syndromes are monitored including the syndromic grouping for conjunctivitis and unexplained fever. for early outbreak detection, a control chart is used based on an adaptation of the cusum methods developed by the cdc within the framework of the ears program (3). results each week, about 700 patients attend the ed of the hospital. the syndromic surveillance system allowed to detect an outbreak of conjunctivitis from week 10 (figure2). during the epidemic peak on week 12, conjunctivitis consultations represented 5% of all consultations. the data of the sentinel practitioner network confirmed this epidemic and the laboratory isolated enterovirus (4). at the same time, an unusual increase of unexplained fever was detected. conclusions due to its geographical and socio-demographical situation, the population of mayotte is widely exposed to infectious diseases. even on a small island, syndromic surveillance can be useful to detect outbreak early leading to alerts and to mobilize a rapid response in addition to others systems. figure1. map of the western indian ocean featuring mayotte island figure2. weekly number of conjonctivitis and unexplained fever consultations and statistical alarms detected keywords syndromic surveillance; early outbreak detection; mayotte island acknowledgments we are thankful to all the sentinel network practitioners and the practitioners of the emergency department. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e149, 2013 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts references 1. lernout t, durquety e, chollet p, helleisen f, javaudin g, lajoinie g, filleul l. [influenza a (h1n1) 2009 surveillance on mayotte island: the challenge of setting up a new system facing the pandemic]. bull soc pathol exot. 2011 may;104(2):114-8. 2. filleul l, durquety e, baroux n, chollet p, cadivel a, lernout t. [the development of non-specific surveillance in mayotte and reunion island in the context of the epidemic influenza a(h1n1)2009] [article in french]. bull epidémiol hebd. 2010;(24-26):283-5. 3. hutwagner l, browne t, seeman gm, fleischauer at. comparing aberration detection methods with simulated data. emerg infect dis. 2005 feb;11(2):314-6. 4. lernout t, maillard o, boireaux s, collet l, filleul l. a large outbreak of conjunctivitis on mayotte island, france, february to may 2012. euro surveill. 2012 jun 7;17(23). pii: 20192. *pascal vilain e-mail: pascal.vilain@ars.sante.fr online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e149, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts extraction of disease occurrence patterns using mistic: salmonellosis in florida vipul raheja* and k. s. rajan international institute of information technology hyderabad (iiit-h), hyderabad, india objective this work leverages spatio-temporal data mining (st-dm), the mistic (mining spatio-temporally invariant cores)[1,6] method for infectious disease surveillance, by identifying a) extent of spatial spread of disease core regions across populations-scale of disease prevalence b) possible causes of the observed patterns-for better prediction, detection & management of infectious disease & its outbreaks introduction infectious diseases, though initially tend to be limited geographically to a reservoir; a subsequent spatial variation in disease prevalence (including spread & intensity) arises from the underlying differences in physical-biological conditions that support pathogen, its vectors & reservoirs. different factors like spatial proximity, physical & social connectivity, & local environmental conditions which add to its susceptibility influence the occurrence[2]. in disease management, analysis of historical data over various aspects of geography, epidemiology, social structures & network dynamics need to be accounted for. large amounts of data raise issues of data processing, storage, pattern identification, etc. in addition, identifying the source of disease occurrence & its pattern can be of immense value. st-dm of disease data can be an effective tool for endemic preparedness[3], as it extracts implicit knowledge, spatial & temporal relationships, or other patterns inherent in such databases. here, core region is defined as a set of spatial entities(eg.counties) aggregated over time, which occur frequently at places having high values in a defined region (considering areas of influence around them)[1]. methods here, mistic algorithm detects spatio-temporally invariant cores with respect to disease occurrence. it involves both a spatial analysis step to detect focal points & a spatio-temporal analysis over the time period of study to identify core regions, which are then classified as – chd, cld & cnd. they refer to cores with high, low and no (mostly random) dominating points respectively based on frequency of occurrences of disease. the predominantly occurring focal points capture the localized behavior of the disease whereas the neighborhood constraints capture the nature (dynamic or non-dynamic) of the event. results county-level annual data of salmonellosis incidence from florida department of health [3] covering a period of 50 years (1961-2010) is used. two types of cores were identified based on type of neighborhood contiguous (cc) & within a defined radius (cr). table1 shows the analysis of counties according to valid frequency criteria for both cc & cr (r=2) & their sub-classification. salmonellosis etiology shows that it is caused by tainted food, hygiene, local environment etc. which are largely sanitation-related [4]. taking the level of urbanization [5] as a proxy for sanitation, it can be seen from fig.1, 12 of 19 cores occur in rural counties. conclusions it is observed that cc is better indicator of cores than cr, implying that salmonellosis manifests itself in a highly localized manner. thus, use of mistic is promising & provides a way for identifying disease “hot-spots”. it also provides valuable insight into the understanding of disease prevalence in different regions based on their history over space and time. classification of core polygons map showing overlay of metropolitan areas and cores keywords disease cores; salmonellosis; spatio-temporal data mining; patterns references 1. k sravanthi, k s rajan: spatio-temporal mining of core regions study of rainfall patterns in monsoonal india. 11th ieee international conference on data mining workshops (icdmw) 2011, pp.30-37 2. chris bailey-kellogg et al.: spatial data mining to support pandemic preparedness. acm sigkdd explorations newsletter. 2006; 8(1):80-82 3. http://www.floridacharts.com [20/5/2012] 4. http://www.cdc.gov/healthypets/diseases/salmonellosis.htm [2/7/2012] 5. http://www.census.gov [25/5/2012] 6. k sravanthi; mistic; ms thesis. iiit hyderabad *vipul raheja e-mail: vipul.raheja@research.iiit.ac.in online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e19, 2013 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts evaluation of syndromic surveillance data streams in animal health morgan hennessey*, julianna b. lenoch, cynthia zepeda, leah estberg and judy akkina usda-aphis-vs, fort collins, co, usa objective to implement a systematic and uniform approach to evaluating data sources for syndromic surveillance within the united states department of agriculture (usda) animal and plant health inspection services (aphis) veterinary services (vs) group. introduction usda-aphis-vs utilizes several continuous data streams to increase our knowledge of animal health and provide situational awareness of emerging animal health issues. in addition, usdaaphis-vs often conducts pilot projects to see if regular data access and analysis are feasible, and if so, if the information generated is useful. syndromic surveillance was developed for three goals: a syndromic monitoring system to identify new diseases, as an emerging disease early warning system, and to provide situational awareness of animal health status. current efforts focus on monitoring diverse data, such as laboratory accessions or poison center calls, grouped into syndromic or other health indicator categories, and are not intended to identify specific pre-determined diseases or pathogens. it is essential to regularly evaluate and re-evaluate the effectiveness of our surveillance program. however, there are difficulties when using traditional surveillance evaluation methods, since the objectives and outcomes of monitoring novel data streams from pilot projects are not easily measurable. an additional challenge in the evaluation of these data streams is the identification of a method that can adapt to various context and inputs to make objective decisions. until recently, assessment efforts have looked at the feasibility of regular analysis and reporting, but not at the utility of the information generated, nor the plausibility and sustainability of longer term or expanded efforts. methods methods for surveillance evaluation, syndromic surveillance evaluation, and specifically for animal health syndromic surveillance evaluation were researched via a literature review, exploration of methods used in-house on traditional surveillance systems, and through development over time of criteria that were seen as key to the development of functioning, sustainable systems focusing on animal health syndromic surveillance. several methods were adapted to create an approach that could organize information in a logical manner, clarify objectives, and make qualitative value assessments in situations where the quantitative aspects of costs and benefits were not always straight forward. more than 25 articles were reviewed to determine the best method of evaluation. results the risksur evaluation support tool (eva) provided the majority of the methodology for the evaluations of our data sources. the eva tool allows for an integrated approach for evaluation, and flexible methods to measure effectiveness and benefits of various data streams. the most useful and common factors found to evaluate pilot data sources of interest were how well the information generated by the data streams could provide early detection of animal health events, and how well and how often situational awareness information on animal health was generated. the eva tool also helps identify and organize criteria that are used to assess the objectives, and assign value. conclusions the regular evaluation of syndromic surveillance data streams in animal health is necessary to make best use of resources and maximize benefits of data stream use. it is also useful to conduct regular interim assessments on data streams in pilot phase to be certain key information for a final evaluation will be generated during the project. the risksur eva tool was found to be very flexible and useful for allowing estimates of value to be made, even when evaluating systems that do not have very specific, quantitatively measurable objectives. this tool provides flexibility in the selection of attributes for evaluation, making it particularly useful when examining pilot project data streams. in combination with additional review methodologies from the literature review, a systematic and uniform approach to data stream evaluation was identified for future use. keywords syndromic surveillance; animal health; emerging disease *morgan hennessey e-mail: morgan.j.hennessey@aphis.usda.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e153, 2017 a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes angella musiimenta 1 1 mbarara university of science and technology, and bishop stuart university kakoba abstract unlike traditional approaches to sexuality and hiv education which can be constrained by the sensitive nature of the subject, information technology (it) can be an innovative teaching tool that can be used to educate people about hiv. this is especially relevant to interventions targeting young people; the population group fond of using it, and the same group that is more vulnerable to hiv/aids. yet, there are significantly few empirical studies that rigorously evaluated computer-assisted school-based hiv/aids interventions in developing countries. the modest studies conducted in this area have largely been conducted in developed countries, leaving little known about the effectiveness of such interventions in low resource settings, which moreover host the majority of hiv/aids infections. this research addresses this gap by conducting a controlled pre-post intervention evaluation of the impacts of the world starts with me (wswm), a computer-assisted hiv/aids intervention implemented in schools in uganda. the research question was: did the wswm intervention significantly influence students’ sexual behaviors, hiv/aids knowledge, attitudes and self-efficacy? to address this question, questionnaires were simultaneously administering to 146 students in an intervention group (the group receiving the wswm intervention) and 146 students in a comparison group (the group who did not receive the wswm intervention), before (february 2009) and after the intervention (december 2009). findings indicate that the intervention significantly improved students’ hiv/aids knowledge, attitudes self-efficacy, sex abstinence and fidelity, but had no significant impact on condom use. the major reason for non-use of condoms was lack of knowledge about condom use which can be attributed to teachers’ failure and inabilities to demonstrate condom use in class. to address this challenge, intervention teachers should be continuously trained in skills-based and interactive sexuality education. this training will equip them with self-confidence and interactive teaching skills, including tactics for emphasizing building students’ skills through role plays and interactive assignments. in addition, the hiv interventions themselves should include interactive virtual condom use demonstrations that can be accessed by students themselves. a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 key words: ict for hiv/aids; wswm; sexual behaviors, knowledge and attitudes; school. 1. introduction 1.1 computer-assisted behavioral change interventions the literature on the effectiveness of computer-assisted behavioral change interventions reports some success in increasing knowledge (coumba et al 2005; campbell et al 2004), changing attitudes, and coping self-efficacy (wikgren 2003; stout et al 2001; gustafson et al 2001; richie et al 2000). however, computer-assisted behavioral change interventions are reported to have limited success in changing behavior and yielding quantifiable health benefits (littlejohns et al 2003; hersh et al 2001; campbell 2004; eysenbach et al 2004; howells et al 2002). although there are significantly few empirical studies focusing on computer-assisted hiv/aids interventions, the modest studies conducted in this area show some positive benefits. there is evidence that computer-assisted hiv/aids innovations increase participants’ knowledge of sexual health and hiv/aids (bailey et al 2010; young and rice 2011; noar et al 2009; tian et al 2007; ito et al 2008; lou et al 2006; halpern et al 2008), attitudes and self-efficacy (gustafson et al 2001; ashton et al 2005; coursaris et al 2009). the efficacy of such interventions on changing sexual behavior such as condom use remains inconclusive (bailey et al 2010; bull et al 2009; wantland et al 2004). however some studies report positive impacts such as reduction of risky sexual behaviors (young and rice 2011), condom use intentions (ito et al 2008); significant reduction on number of partners, and increased condom use (noar et al 2009). despite the potential benefits, most of these studies have been conducted in developed countries, leaving little known about the effectiveness of computer-assisted hiv/aids interventions in developing countries. moreover, the loss of life, and the social and economic burdens created by hiv/aids (e.g. carer burdens on affected families, lost output in productivity and burdens on healthcare facilities are sufficiently severe to justify the need for targeting research and intervention to the prevention of hiv/aids in developing countries (muller 2005). 1.2 the evaluation of school-based sexuality and hiv/aids interventions although there is some evidence from previous studies of increased hiv/aids knowledge and attitudes from school-based hiv/aids intervention (cheng et al 2008; jahanfar et al 2009), impacts on sexual behavior remain inconclusive as the same studies report no differences in students’ behavioral scores. out of 49 interventions to prevent hiv/aids and pregnancy in the united states, only four interventions increased the use of condoms or other contraceptives (kirby et al 1995). another review of 26 pregnancy prevention interventions (including 10 school-based ones) reported no effect on sex abstinence, condom use or unplanned pregnancy (dicenso et al 2002). it can be argued that the absence of significant effects on behavioral change is a result of limited behavioral-gap due to the shortness of follow-up assessments that are normally allowed by school-based evaluation. however, results from walker et al (2006) defeat this argument, since even the increase in condom use a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 reported immediately after the intervention could not be maintained one year after the intervention. in addition, in a long follow-up, wight et al (2002) report no statistically significant difference on students’ rate of contraception uptake. noteworthy, however, is that some reviews indicate that school-based interventions can decrease students’ hiv/aids risky behavior (lonczak et al 2002). overall, whether or not school-based hiv/aids interventions influence students’ sexual behavior remains highly controversial. in addition, school-based hiv/aids studies have largely been conducted in developed countries, leaving little known about the effectiveness of such interventions in low resource settings, which moreover host the majority of hiv/aids infections. recent meta-analyses persistently caution of a lack of rigorous evaluation of school-based hiv/aids interventions in africa (magnussen et al 2004; paul-ebhohimhen et al 2008), while a recent literature review of 87 studies, 70% of which were school-based, affirms a lack of evaluated sexuality and hiv interventions in developing countries (unesco 2009). uganda is among the sub-saharan african countries that has been severely infected and affected by hiv/aids since 1982. although the country had recorded a decline in hiv/aids rates in 1990’s, the rates started increasing again especially among the youth (ministry of health uganda 2005; biraro et al 2009). this increase has attracted some local and international organisations to implement hiv interventions targeting young people, of which the world starts with me (wswm) the intervention evaluated in this study is one of such interventions. this investigation aimed to assess the level of significance of the impacts of the wswm on students’ sexual behaviors, knowledge of hiv/aids, attitudes and perceived self-efficacy. 2. methodology 2.1 the world starts with me (wswm) intervention developed by butterfly works, schoolnet uganda and uganda local experts, the wswm is a fourteen-lesson computer-assisted sexuality and hiv/aids intervention implemented in over 200 secondary schools in uganda since 2003. this intervention has also been implemented in kenya, india, thailand, indonesia, and vietnam under the same sponsorship of world population foundation (wpf). in uganda, it is delivered in classrooms with the help of oriented intervention teachers using the web-based version (http://www.theworldstarts.org), the cd-rom and/or the hard copy version. by 2008, over 8,000 young people had accessed the intervention website, 2000 young people had accessed the intervention print-outs. other it-related features of this intervention include the online counselling and support centre (http://schoolnetuganda.sc.ug/wswmonlinesupport/) that enables the exchange of sexual health and hiv/aids-related information between sexual reproductive health counsellors and young people. included also is the use of virtual peer educators, interactive safer sex quizzes, story boards, and role plays. 2.2 the intervention and control groups the major objective of this investigation was to assess the level of statistical significance of the impacts of the wswm intervention on students. to achieve this objective, this investigation involved the intervention group and the comparison group (the group that never had the intervention). investigating the intervention and comparison groups before and after http://www.theworldstarts.org/ http://schoolnetuganda.sc.ug/wswmonlinesupport/ a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 the intervention improves the reliability with which the identified intervention impacts can be attributed to the intervention, rather than to external factors (wyatt 2000; remenyi et al 2002; wyatt and wyatt 2003). the controlled pre-post intervention study is based on the second cycle of the intervention that ran from february 2009-december 2009. the comparison school did not implement the intervention at any time prior to or during the period of this research. permission to investigate the intervention school was obtained from the intervention leader (the executive and training director-etd) between may and september 2008. this school was selected due to the researcher’s initial contact with the intervention teachers, the anticipated high hiv vulnerability of students since it was a school in a military barracks with many war-orphaned students, and the school’s close proximity to the researcher’s residence. the intervention teachers used three computers connected on the internet, one television set that used an intervention cd, and computer print-outs to deliver the intervention. authorisation to investigate the comparison school was obtained from the head of school in january 2009. this comparison school was selected due to the anticipated similarities with the intervention school since it was also located in a military barracks with many war-orphaned students. as shown in table 1 below, there was no statistically significant difference in the demographic characteristics of the intervention and comparison groups at pre-test. 2.3 participant selection the researcher had no control regarding the implementation procedures of the intervention including the enrollment of students into the intervention. thus, this investigation relied on groups that pre-existed in schools. the school’s fixed implementation procedures and timetables of the intervention dictated the choice and the number of participants. the intervention school had a total of 180 students in senior one, 83 of whom were in stream a, while 77 were in stream b. in february 2009 when this study started, 152 students had registered their names to attend the intervention, all of whom were involved in the pre-test assessment of this study. the comparison group had a total of 218 students in senior one in three streams i.e. 72 students in stream a, 76 in stream b and 70 in stream c. in order to get a relatively equal number of participants in the intervention and comparison groups, stream a and stream b (148 participants) were involved in the present study. in both schools, participants were requested by intervention teachers to enroll for this study and were also informed that their participation had no impact on their academic assessment. 2.4 outcome measures 2.4.1 sexual behaviors there were three main measures for sexual behaviors: abstinence, number of sexual partners and condom use, which were measured using 5 statements as shown in table 2. participants were also asked to state reasons for use or non-use of condoms at last sex. 2.4.2 hiv/aids awareness and perception of vulnerability seven statements were employed to measure these variables (table 4). the questions were extracted from a questionnaire that had been specifically previously developed by the centre for aids prevention studies, california and pilot-tested on junior high school students in california (population council 2008). using previously developed and tested questions a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 ensures reliability of findings (wyatt and wyatt 2003). some questions on aids-related knowledge that the present study rendered culturally inappropriate were excluded. each statement was assessed using a four-point likert scale measuring the degree of agreement or disagreement with the statement, ranging from “strongly agree” to “strongly disagree” including an option for “no answer”. 2.4.3 attitudes towards girls’ condom initiation and negotiation this assessment used eight statements adapted from a questionnaire which was developed, validated and used in a programme for hiv prevention in thai schools (population council 2008). only statements related to attitudes towards young women’s condom use were adapted (table 5). minor adjustments were made to statements in order to emphasise girls’ initiation and negotiation of condom use. this was done by introducing the word “girl” in many of the statements. for example, a statement such as: “if i carry a condom, my partner will think that i am planning to have sex”, was adjusted to “if a girl carries a condom, her partner will think that she is planning to have sex.” each statement was assessed using a four point likert scale measuring the degree of agreement or disagreement with the statement, ranging from “strongly agree” to “strongly disagree” including the option for “no answer”. 2.4.4 adherence to men’s infidelity-related norms participants were asked the extent to which they believe in the statement: “whereas it is ok for boys/men to have more than one sexual partner at the same time, girls/women should only have one sexual partner at the same time”. a four-point likert scale was used to measure the degree of agreement or disagreement with the above statement, ranging from “strongly agree” to “strongly disagree”, including the option for “no answer”. 2.4.5 girls’ perceptions of condom assertiveness self-efficacy girls’ perceptions of condom assertiveness self-efficacy were assessed by the sexual assertiveness scale (sas) (population council 2008), which has a proven reliability among diverse female populations. sas was developed and validated from four studies that sampled 513 young women of at least 18 years of age. in line with aim of the present study, sas’s subscale for pregnancy-std prevention was adapted. no major modifications were made to the statements apart from replacing the term “latex barrier” with the term “condom”. this is was after realising from pilot tests of the questionnaires that the majority of respondents had never heard about latex barriers. five statements (table 7) were assessed using a four-point likert scale measuring the degree of agreement with each statement, ranging from “strongly agree” to “strongly disagree”, including the option for “no answer.” 2.5 the pre-test and post-test data collection the pre-test and post-test studies consisted of the simultaneous administering of the same questionnaire to both the intervention and comparison groups at pre-test in february 2009, one week before the intervention group was exposed to the intervention, and at post-test in december 2009 one week after the intervention group was exposed to the intervention. the pre-test questionnaire was aimed at exploring the initial status of students’ sexual behaviors, hiv/aids knowledge, hiv-related self-efficacy and attitudes. these results were later used as a basis for comparison when explaining the impacts of the intervention. a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 the post-test questionnaire was aimed at exploring the immediate impact of the intervention on students’ sexual behaviors, hiv/aids knowledge, self-efficacy and attitudes. both the pre-test and post-test questionnaires were the same in content, except that demographic questions were only included in the pre-test questionnaires. the pre-test involved 300 participants, of whom 152 were in the intervention group and 148 in the comparison group. however, the post-test involved 292 participants, of whom 146 belonged to the intervention group, while 146 were in the comparison group. during the posttest assessment, eight participants were absent from their respective schools and were therefore excluded from the study. for both the pre-test and post-test of the intervention and comparison groups, participants were gathered in one hall where questionnaires were distributed and collected immediately after completing them. questionnaires were administered by peers (who were class leaders) rather than the researcher as it was anticipated that participants were more likely to open up while filling in the questionnaires distributed by peers rather than the researcher. prior to administering the questionnaires, the researcher introduced the objectives of the questionnaire to the participants. this introduction involved assuring participants of the confidentiality of the information being collected, and giving them codes that were to be used as reference points during the post-study follow-up. peers were briefed about the contents of the questionnaire as well as about questionnaire administering. the researcher remained within the school environment while peers administered the questionnaires in order to attend to any queries that peers would not be able to answer. the total duration taken by participants to fill in the questionnaire ranged between 15-30 minutes. 2.6 the pre-test and post-test data analysis the pre-test and post-test data collected from the groups was coded, entered and entered into spss version 16.0 for analysis. responses to likert-scaled statements were treated as ordinal/ranked variables and assigned codes; code 1 for “strongly agree” to code 4 for “strongly disagree”, and 5 for “no answer”. none of the respondents selected the “no answer” option, thus, this option was ignored. wilcoxon signed rank test was employed to assess the level of significance of impacts of the intervention on sexual behaviors. wilcoxon signed rank test requires two nominal variables and one measurement variable (pallant 2007). in this study, pre-test and post-test scores represent the first nominal variable, assessment statements represent the second nominal variable, while percentages represent measurement variable (e.g. see mcdonald 2008). response for the assessments of sexual behaviors were given numerical codes, treated as nominal variables and summarised using descriptive statistics. the statistics were then treated as continuous variables and analysed using wilcoxon signed rank test. this approach is recommended by (mcdonald 2008) for “ambiguous variables” which seem not to perfectly qualify for continuous, nominal or ordinal/ranked variables, as is the case in the variables used for assessment of sexual behaviors. paired-sample t-tests were applied to assess the impacts of the intervention by comparing the, hiv/aids knowledge, attitudes and self-efficacy at the pre-test and post-test assessments of the intervention group. the paired samples t-test (also referred to as repeated measures) is a statistical measure used to assess the level of significance in mean scores of a group, or more than one group, investigated at pre-test and at post-test (pallant 2007). wilcoxon signed rank test and paired sample t-tests calculate the probability (p) values of responses in each statement for pre and post assessments to determine the level of significance. p<=0.05 a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 implies a statistical significance difference, while p>= 0.05 denotes an insignificant difference (pallant 2007). paired sample t-tests have also been effectively used by other researchers (jahanfar et al 2009) evaluating hiv interventions that involved the pre-test and post-test assessments. 2.7 social-demographic details of participants table 1: descriptive statistics for the social-demographic variables for the intervention and the comparison groups at pre-test variable intervention group (max n = 146) comparison group (max n = 146) sex male =61(42%) female =85(58%) total =146(100%) male =46(32%) female =100(68%) total =146(100%) age (years) 11-13 14-16 24(16%) 37(25%) 17(12%) 68(47%) 41(28%) 105(72%) n=146(100%) 14(10%) 32(22%) 23(15%) 77(53%) 37(25%) 109(75%) n=146(100%) religion christian muslim 47(32%) 14(10%) 80(55%) 5(3%) 127(87%) 19(13%) n=146(100%) 44(30%) 2(1%) 89(61%) 11(8%) 133(91%) 13(9%) n=146(100%) parental status one or both parent dead both parents alive 49(34%) 12(8%) 57(39%) 28(19%) 106(73%) 40(27%) n=146(100%) 34(23%) 12(8%) 63(43%) 37(25%) 97(66%) 49(34%) n=146(100%) parent occupation 1 non-professionals professionals 50(34%) 11(8%) 67(46%) 18(12%) 117(80%) 29(20%) n=146(100%) 43(30%) 3(2%) 85(58%) 15(10%) 128(88%) 18(12%) n=146(100%) max n = maximum number of participants. 1 professional occupation includes engineers, lawyers, and teachers. non-professional occupations include soldiers, shop keepers, and farmers. the majority of students were within the age range of 14-16 years, were christians, orphans, and had parents with non-professional jobs. family background e.g. a lack of parents or poverty may explain the wide age range in senior one. a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 3. results 3.1 impact on sexual behaviors table 2: wilcoxon signed rank test demonstrating the differences in sexual behaviors between pre-test and post-test for the intervention and the comparison groups sexual behaviors assessment statements intervention group (n = 145) comparison group (n = 145) paired intervention & comparison (n=145) pre(%) post(%) p pre(%) post(%) p pre(p) post(p) number of partners/abstinence not had sex in the last three months 61 73 0.00 59 58 0.16 0 16 0.00 had sex with 1 partner in the last 3 months. 22 12 0.00 23 21 0.16 0.32 0.00 had sex with 2 or more partners in the last 3 month 17 14 0.05 15 17 0.08 0.83 0.05 condom use ever used condom 45 46 0.32 43 44 0.60 0.08 0.57 used condom at last sex 23 25 0.64 21 23 0.26 0.08 0.64 compared to comparison group, the intervention had a statistically significant influence on students’ sex abstinence; (from 61% at pre-intervention to 73% at post-intervention; p=0.00) reporting not to have had sex in the last three months. having sex with one partner in the last three months significantly reduced from 22% to 12%; p=0.00, while having sex with two or more partners significantly reduced from 17% to 14; p=0.00. however, the intervention had no significant impact on students’ condom use. three factors strongly contributed to students’ non-use of condoms at last sex: lack of knowledge of using condoms (25%); feelings of embarrassment associated with buying and suggesting condom use (21) %; and perceptions that one can still get hiv/aids even if condoms are used (3%). a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 3.2 impact on hiv/aids awareness and perception of vulnerability table 4: paired sample t-tests demonstrating the hiv/aids knowledge scores for the intervention and comparison groups at pre-test and post-test knowledge assessment statements intervention group (n = 146) comparison group (n = 146) paired intervention & comparison (n=146) m1 m2 sd p m1 m2 sd p p1 p2 showering, or washing one's private parts after sex keeps a person from getting hiv/aids 3.33 3.51 0.38 0.00 3.25 3.30 0.47 0.22 0.07 0.00 eating healthy foods can keep a person from getting hiv/aids 3.42 3.58 0.36 0.00 3.37 3.38 0.83 0.32 0.25 0.00 taking the birth control pill keeps a woman from getting hiv/aids 3.24 3.61 0.56 0.00 3.18 3.23 0.32 0.07 0.06 0.00 a person with hiv/aids can look and feel healthy 2.62 2.34 1.41 0.02 2.55 2.56 0.33 0.62 0.06 0.05 there is a vaccine that can cure people from hiv/aids 3.17 3.50 0.51 0.00 3.16 3.21 0.57 0.39 0.32 0.00 a person can get hiv/aids even if she or he has sex with another person only one time 2.22 1.69 0.88 0.00 2.22 2.19 0.42 0.44 0.32 0.00 people are likely to get hiv/aids by deep kissing, putting their tongue in their partner's mouth, if their partner has hiv/aids 2.60 2.24 0.76 0.00 2.64 2.56 0.57 0.66 0.20 0.00 m1= mean at pre-test; m2= mean at post-test; sd=standard deviation; p= within-group p-value, p1= between-group p-value at pre-test; p2= between-group p-value at post-test; n=number of responses unlike the comparison group, the intervention group experienced statistically significant mean increases in the likelihood of participants to disagree with misconceptions of associating hiv/aids cure with washing ones private parts (m1=3.33 to m2=3.51; sd=0.38; p=0.00), eating healthy foods (m1=3.42 to m2=3.58; sd=0.36; p=0.00), taking birth control pills (m1=3.24 to m2=3.61; sd=0.56; p=0.00), and existence of vaccination for hiv/aids cure (m1=3.17 to m2=3.50; sd=; p=0.00). the group was also significantly likely to disagree that a person can get aids from having sex only once (m1=2.22 to m2=1.69; sd=0.88; p=0.00), can get aids from deep kissing (m1=2.60 to m2=2.24; sd=0.76; p=0.00), and that a person with hiv/aids can feel and look healthy (m1=2.62 to m2=2.34; sd=1.41; p=0.02). a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 3.3 attitudes towards girls’ condom initiation and negotiation table 5: paired sample t-tests demonstrating the attitudes towards gender equity in condom use initiation and negotiation scores for the intervention and comparison groups at pre-test and post-test statement for assessing gender equity in condom negotiation intervention group (n = 146) comparison group ( n=146) paired intervention & comparison (n=146) m1 m2 sd p m1 m2 sd p p1 p2 if a girl carries a condom, her partner will think that she is planning to have sex. 2.13 2.26 0.67 0.02 2.13 2.12 0.19 0.66 0.32 0.02 a girl loses a man’s respect if she asks him to use a condom 2.74 2.83 0.44 0.02 2.72 2.74 0.14 0.08 0.08 0.02 it is embarrassing for a girl to buy or ask for condoms 2.14 2.09 0. 33 0.05 2.16 2.14 0.50 0.61 0.25 0.05 using a condom is a sign of girls not trusting their partner 2.33 2.21 0.53 0.00 2.35 2.36 0.17 0.32 0.32 0.03 condom use initiation should only be done by boys 3.13 3.18 0.30 0.05 3.12 3.11 0.08 0.32 0.32 0.02 if a girl carries a condom it means they are experienced in sexual matters 2.37 2.44 .0.42 0.05 2.35 2.36 0.08 0.32 0.18 0.02 girls who carry condoms and insist on using them are prostitutes and such girls are not respected 2.39 2.47 0.42 0.02 2.40 2.42 0.17 0.32 0.32 0.05 it is okay for a girl to suggest condom use 1.72 1.62 0.43 0.00 1.74 1.75 0.08 0.32 0.18 0.00 unlike the comparison group, the intervention group experienced a significant mean decrease in the like hood of students to associate girl’s condom carrying and negotiation with planning to have sex (m1=2.13, m=2.26; sd=0.67; p=0.02), loss of respect (m1=2.74, m2=2.83; sd=0.44; p=0.02), embarrassment (m1=2.14, m2=2.09; sd=0.33; p=0.05), lack of trust (m1=2.33, sd=0.53; m2=2.21; p=0.00), sexual experience (m1=2.37, m2=2.44; sd=0.42; p=0.05), and prostitution (m1=2.39, m2=2.47; sd=0.42; p=0.02). unlike the comparison group, the intervention group significantly disagree that condom use initiation should only be done by boys (m1=3.13, m2=3.18; sd=0.30; p=0.05), and significantly agree that girls can suggest condom use (m1=1.72, m2=1.62; sd=0.43; p=0.00). a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 3.4 attitudes towards men’s infidelity-related norms table 6: paired sample t-tests demonstrating the attitudes towards norms that condone multiple sexual partners for men for the intervention and comparison groups at pre-test and post-test statement for assessing attitude towards norms condoning men’s multiple sexual partners intervention group ( n=145) comparison group (n=145) paired intervention & comparison (n=145) m1 m2 sd p m1 m2 sd p p1 p2 whereas it is ok for boys/men to have more than one sexual partner at the same time, girls/women should only have one sexual partner at one time 2.56 2.75 0.81 0.00 2.55 2.57 0.60 0.68 0.78 0.03 unlike the comparison group (m1=2.45, m2=2.57; sd=0.60; p=0.68), the intervention group experienced statistically significant mean increases (m1=2.56, m2=2.75; sd=0.81; p=0.00) in the likelihood of participants to disagree that men should have multiple sexual partners while at the same time women should have only one partner. 3.5 impact on girls’ sexual and condom assertiveness self-efficacy table 7: paired sample t-tests demonstrating girls’ perceived condom assertiveness selfefficacy scores for the intervention and comparison at both pre-test and post-test statements used to assess girls’ perceived condom assertiveness self-efficacy intervention group (n =84) comparison group (n =84) paired intervention & comparison (n=84) m1 m2 sd p m1 m2 sd p p1 p2 i could have sex without a condom if my partner doesn’t like them, even if i want to use one. 3.05 3.39 1.05 0.00 3.03 3.01 0.22 0.32 0.32 0.00 i could make sure my partner and i use a condom when we have sex. 2.09 1.48 1.26 0.00 2.11 2.09 0.15 0.16 0.16 0.00 i could have sex without using a condom if my partner wants 3.00 3.43 1.11 0.00 2.98 2.97 0.11 0.32 0.32 0.00 i could insist on using a condom even if my partner doesn't want them 2.76 2.45 0.73 0.00 2.77 2.75 0.15 0.16 0.32 0.00 i could refuse to have sex if my partner refuses to use a condom 2.16 1.55 0.96 0.00 2.18 2.20 0.15 0.16 0.32 0.00 note: this question was only meant for girls. a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 before the intervention, there were no statistically significant differences between the intervention and comparison groups regarding their perceived condom assertiveness selfefficacy. however, after the intervention, there were statistically significant differences between the two groups. this implies that the intervention had a significant effect on girls’ perceived condom assertiveness self-efficacy. for example, unlike the comparison group, participants in the intervention group significantly agreed that they would make sure that they use condoms (m1=2.09, m2=1.48; sd=1.26; p=0.00), insist on using condoms (m1=2.76, m2=2.45; sd=0.73; p=0.05), and refuse to have unprotected sex (m1=2.16, m2=1.55; sd=0.96; p=0.03). 4. discussion 4.1 impact on sexual behaviors results indicate that the intervention had significant impact on students’ sex abstinence and partner faithfulness. this is similar to the contentions of previous studies investigating computer-assisted hiv interventions as they reported reduction in the number of sexual partners (noar et al 2009), reduction in risky sexual behaviors (young and rice 2011). despite the significant influence on sex abstinence and partner faithfulness, the impact on condom use was not significant. an insignificant impact of computer-assisted interventions on condom use is consistent with those of previous researchers (bailey et al 2010; bull et al 2009; wantland et al 2004). although the present study reports results of a short follow-up, a longer follow-up of 18 years olds still showed no significant impacts on unprotected sex (stephenson et al 2004). walker et al (2006) report students inability to maintain the behavioral impacts (condom use in particular) reported during short follow-up. three reasons (i.e. lack of knowledge of using condoms, feelings of embarrassment associated with buying and suggesting condom use, and perceptions that one can still get hiv/aids even if condoms are used) largely contributed to non-use of condoms. other mediators that constrained condom use include: perceptions that condoms cause cancer and contain germs, lack of money to buy condoms, desire to prove manhood by making girls pregnant, perception of partner trust, condoms’ interference in sexual pleasure, perceptions that students don’t fit in condoms resulting in condoms slipping off and remaining in a girl’s body, and religious constraints. other studies also report constraints in condom use e.g. challenges in initiation and negotiation (sionean et al 2002), religious constraints (mosley 2003), and partner trust (kelly & parker 2000). the condom use constraint of lack of skills may have been attributed by intervention teachers’ failure to practically demonstrate condom use in class as it was reported in the results of implementation evaluation. the intervention teachers’ reservations on teaching about condom use ultimately influenced their level of condom emphasis and details revealed to students. teachers’ failure and inabilities to demonstrate condom use is also reported in a recent systematic review (shepherd et al 2010). 4.2 hiv/aids knowledge consistent with those other researchers (bailey et al 2010; young and rice 2011; noar et al 2010; tain et al 2007; ito et al 2008; lou et al 2006; halpern et al 2008), the present study indicates that the computer-assisted hiv/aids intervention significantly influenced students’ knowledge of hiv/aids transmission and prevention. compared to the comparison group, students in the intervention group were significantly more likely to disagree that hiv/aids can be prevented by: washing private parts after sex, eating healthy foods, taking birth control a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 pills, and to disagree that there is a vaccination that cures hiv/aids. also, compared to the comparison group, the intervention group were significantly more likely to agree that a person can get aids from having sex only once and deep kissing and to agree that a person with hiv/aids can feel and look healthy. although increase in knowledge does not always guarantee changes in behavior, reliable information especially about the involved risks can be vital in motivating health behavioral change (prochaska and diclemente 1983). 4.3 attitudes towards girls’ condom initiation and negotiation. cultural expectations of women’s passiveness and ignorance in sexuality constrain their sexual negotiating power, including negotiating for safer practices (pearson 2006). computer-assisted hiv interventions can significantly influence people’s attitudes towards hiv prevention (coursaris et al 2009). the present study reports statistically significant improvement in students’ perceptions of girls’ condom negotiation, and in attitudes towards men’s infidelity practices. the positive attitudes towards females’ condom negotiation present an important step forward in tackling the gender-related vulnerability of hiv/aids and pregnancy. 4.4 attitudes towards and men’s infidelity-related norms compared to the comparison group, the intervention group experienced significant reduction in participants’ adherence to the socially defined gender-biased ideologies that condone men’s practice of having concurrent multiple sexual partners while constraining women’s sexuality to single partners. studies evaluating hiv school-based interventions rarely incorporate gender-related constructs in their assessments. noteworthy, thought not schoolbased, studies such as coursaris et al (2009) report significant influence in attitudes resulting from computer-assisted hiv interventions. 4.5 girls’ sexual and condom assertiveness self-efficacy results indicate a significant increase in girls’ sexual and condom assertiveness self-efficacy. given the persistently reported students’ difficulties in practical translation of hiv knowledge to hiv prevention practices (bazargan et al 2000), the reported improvements in hiv/aids knowledge and attitudes may not make significant impact on behaviors without appropriate self-efficacy to adopt hiv preventive measures. self-efficacy plays an important role in closing the awareness-behavior gap by equipping individuals with positive capability beliefs and abilities to adopt healthy behaviors (rimal 2000). previous studies also report improved young women’s refusal self-efficacy (karnell et al 2006) and condom negotiation self-efficacy (roberto et al 2007) after exposure to the sexuality intervention. while computer-assisted studies (e.g. gustafson et al 2001; ashton et al 2005; coursaris et al 2009) affirm positive influence on participant’s self-efficacy. girl’s condom negotiation and sexual assertiveness self-efficacy has a direct relationship with condom use (sionean et al 2002). the reported distinctive condom negotiation self-efficacy and sexual assertiveness can be instrumental in combating hiv/aids and its uneven burdensome consequences among young women. a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 5. limitation of the study if the experimental conditions permitted, rather than using pre-existing groups in two schools, randomly allocating participants to the intervention and control groups within the same school would have improved the reliability of the results. however, given the free interaction of students in the school environment, drawing groups within the same school would have been reliable to a challenge of ensuring that participants in the control group are completely uninfluenced by the intervention. stephenson et al (2008) also warns about this potential methodological bias resulting from the spreading of the school-based sexuality interventions to control groups. in addition, this approach was not feasible due to the researcher’s limited control on the implementation procedures of the intervention. nearly all the students in senior one of the intervention group had registered to attend the intervention. this implies that there were not enough participants to be allocated to the comparison group. the only option was to draw the comparison group from another school, separate from the intervention school. thus, rather than composing and randomly allocating groups, this study relied on groups that pre-existed in separate schools. the fixed schools’ implementation procedures and timetables of the intervention dictated the choice and the number of participants. nevertheless, the pre-test analysis indicated no significant differences between the intervention and the comparison groups. 6. conclusion this paper conducted a quantitative pre-post intervention study aimed at investigating the impacts of the computer-assisted sexuality and hiv/aids intervention implemented in schools in uganda. to achieve this aim, questionnaire was administered to both the intervention group (n=146) and the comparison group (n=146) at pre-test (february 2009) and at post-test (december 2009). the results indicate that the intervention significantly improved students’ sex abstinence and reduction in number of sexual partners, improved knowledge and perception of vulnerability to hiv/aids, improved their attitudes towards gender equity in hiv/aids and pregnancy prevention, reduced adherence to men’s infidelity-related norms and improved girls’ perception of condom assertiveness self-efficacy. however, condom use appeared to be unaffected by the intervention. three reasons significantly contributed to non-use of condoms: lack of skills in using condoms which was mainly attributed to lack of practical condom use demonstrations in classes, feelings of embarrassment associated with buying and suggesting condom use and perceptions that one can still get hiv/aids even if condoms are used. teachers training in skills-based and interactive sexuality education, inclusion of interactive virtual condom use demonstrations in the web-based version of the intervention, and community sensitisations about the role of condoms in hiv prevention can help address these condom use constraints. a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 corresponding author angella musiimenta senior lecturer mbarara university of science and technology bishop stuart university email: angellamusiimenta@yahoo.com references 1. ashton e, vosvick m, chesney m, gore-felton c, koopman c, et al. 2005. social support and maladaptive coping as predictors of the change in physical health symptoms among persons living with hiv/aids. am j public health. •••, 1027-30. 2. bailey jv, murray e, rait g, mercer ch, morris rw, et al. 2010. interactive computerbased interventions for sexual health promotion. cochrane database syst rev. 9. 3. bazargan m, kelly em, stein ja, hussain ba, bazargan hs. 2000. correlates of hiv risk-taking behaviors among african-american college students. the effect of hiv knowledge, motivation and behavioral skills. j natl med assoc. 92(8), 391-404. 4. biraro s, shafer la, kleinschmid i, wolff b, karabalinde a, et al. 2009. is sexual risk taking behavior changing in rural south-west uganda? behavior trends in a rural population cohort 1993-2006. sex transm infect. 85, i3-11. http://dx.doi.org/10.1136/ sti.2008.033928 5. bull ss, pratte k, whitesell n, rietmeijer c, mcfarlane m. 2009. effects of an internetbased intervention for hiv prevention: the youth trials. aids behav. 13, 474-87. http:// dx.doi.org/10.1007/s10461-008-9487-9 6. campbell ca. 1995. male gender roles and sexuality: implications for women’s aids risk and prevention. soc sci med. 41(2), 197-210. http:// dx.doi.org/10.1016/0277-9536(94)00322-k 7. coumba, m.g. (2005). exploring the gender impacts of world links in some selected african countries: a qualitative approach. [online]. available from: http:world-links.org/ english/assets/gender_study_v2.pdf [accessed on 12 august 2008]. 8. cheng y, lou ch, mueller ma, zhao sl, yang jh, et al. 2008. effectiveness of a schoolbased aids education program among rural students in high epidemic area of china. j adolesc health. 42, 184-91. http://dx.doi.org/10.1016/j.jadohealth.2007.07.016 9. coursaris ck, liu m. 2009. analysis of social support exchanges in online hiv/aids self-help groups. comput human behav. 25, 911-18. http://dx.doi.org/10.1016/ j.chb.2009.03.006 10. dicenso a, guyatt g, willan a, griffith l. 2002. interventions to reduce unintended pregnancies among adolescents: systematic review of randomised controlled trial. bmj. 324, 1-9. http://dx.doi.org/10.1136/bmj.324.7351.1426 11. eysenbach g, powell j, englesakis m, rizo c, stern a. 2004. health related virtual communities and electronic support groups: systematic review of the effects of online peer to peer interactions. bmj. 328(7449), 1166. http://dx.doi.org/10.1136/ bmj.328.7449.1166 mailto:angellamusiimenta@yahoo.com a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 12. gustafson dh, hawkins r, boberg e, pingree s, serlin re, et al. 2001. impact of a patient centred computer-based health information support. am j prev med. 16(1). 13. halpern ct, mitchell emh, farhat t, bardsley p. 2008. effectiveness of web-based education on kenyan and brazilian adolescents’ knowledge about hiv/aids, abortion law, and emergency contraception: findings from teenweb. soc sci med. 67, 628-37. http://dx.doi.org/10.1016/j.socscimed.2008.05.001 14. hersh wr, helfand m, wallace j, kraemer d, patterson p, et al. 2001. clinical outcomes resulting from telemedicine interventions: a systematic review. bmc med inform decis mak. 1(1), 5. http://dx.doi.org/10.1186/1472-6947-1-5 15. howells l. 2002. a randomised control trial of the effect of negotiated telephone support on glycaemic control in young people with type 1 diabetes. diabet med. 19(8), 643-48. http://dx.doi.org/10.1046/j.1464-5491.2002.00791.x 16. jahanfar s, lye ms, rampal l. 2009. a randomised controlled trail of peer adult-led intervention on improvement of knowledge, attitudes and behavior of university students regarding hiv/aids in malaysia. singapore med j. 50(2), 173-80. 17. jemmott j, jemmott l, fong g. 2010. efficacy of a theory-based abstinence-only intervention over 24 months: a randomized controlled trial with young adolescents. arch pediatr adolesc med. 164(2), 152-59. http://dx.doi.org/10.1001/archpediatrics.2009.267 18. littlejohns p, wyatt jc, garvican l. 2003. evaluating computerised health information systems: hard lessons still to be learnt. bmj. 326, 860-63. http://dx.doi.org/10.1136/ bmj.326.7394.860 19. ito ke, kalyanaraman s, ford ca, brown jd, miller wc. 2008. "let's talk about sex": pilot study of an interactive cd-rom to prevent hiv/stis in female adolescents. aids educ prev. 20(1), 78-89. http://dx.doi.org/10.1521/aeap.2008.20.1.78 20. karnell ap, cupp pk, zimmerman rs, feist-price s, bennie t. 2006. efficacy of an american alcohol and hiv prevention curriculum adapted for use in south africa: results of a pilot study in five township schools. aids educ prev. 18, 295-310. http:// dx.doi.org/10.1521/aeap.2006.18.4.295 21. kirby d. (1995). a review of educational programs designed to reduce sexual risktaking behaviors among school-aged youth in the united states. springfield, virginia: national technical information service. 22. lonczak h, abbott r, hawkins d, kosterman r, catalano r. 2002. effects of the seattle social development project on sexual behavior, pregnancy, birth and sexually transmitted disease outcomes by age 21 years. arch pediatr adolesc med. 156, 438-47. http:// dx.doi.org/10.1001/archpedi.156.5.438 23. lou c, zhao q, gao e, shah hi. 2006. can the internet be used effectively to provide sex education to young people in china? j adolesc health. 39, 720-28. http:// dx.doi.org/10.1016/j.jadohealth.2006.04.003 24. mayisha ii collaborative group. (2005). assessing the feasibility and acceptability of community-based prevalence surveys of hiv among black african in england. london: health protection agency centre for infections. 25. mcdonald jh. (2008). the handbook of biological statistics. [e-book]. baltimore, maryland: sparky house publishing. available from: http://udel.edu/~mcdonald/ statpermissions.html 26. ministry of health uganda. (2005). hiv/aids sero-behavioral survey, 2004-2005. preliminary report, kampala. 27. muller tr. (2005). hiv/aids, gender and rural livehoods in sub-saharan africa. netherlands: wageningen academic publishers. a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 28. noar sm, pierce lb, black hg. 2010. can computer-mediated interventions change theoretical mediators of safer sex? a meta-analysis. hum commun res. 36(3). http:// dx.doi.org/10.1111/j.1468-2958.2010.01376.x 29. noar sm, black hg, pierce lb. 2009. efficacy of computer technology-based hiv prevention interventions: a meta-analysis. aids. 23(1), 107-15. http://dx.doi.org/10.1097/ qad.0b013e32831c5500 30. pallant j. (2007). a step-by-step guide to data analysis using spss version 15. 3rd ed. england: open university press. 31. pearson j. 2006. personal control, self-efficacy in sexual negotiations, and contraceptive risk among adolescents: the role of gender. sex roles. 54, 615-25. http:// dx.doi.org/10.1007/s11199-006-9028-9 32. population council. (2008). aidsquest survey library. [online]. available from: http:// www.popcouncil.org/horizons/ortoolkit/aidsquest/topics/knowledge.html. [accessed 20 january 2008]. 33. prochaska jo, diclemente cc. 1982. transtheoretical therapy: towards a more integrative model of change. psychotherapy. 19(3), 276-87. http://dx.doi.org/10.1037/ h0088437 34. remenyi d, williams b, money a, swartz e. (2002). doing research in business and management: an introduction to process and methods. london: sage. 35. richie j, stewart m, ellerton ml, thompson d, meade d, et al. 2000. parents’ perceptions of the impacts of a telephone support group intervention. j fam nurs. 6(1), 25-45. http://dx.doi.org/10.1177/107484070000600103 36. rimal rn. 2000. closing the knowledge-behavior gap in health promotions: the mediating role of self-efficacy. health commun. 12, 219-37. http://dx.doi.org/10.1207/ s15327027hc1203_01 37. roberto aj, zimmerman rs, carlyle ke, abner el. 2007. a computer-based approach to preventing pregnancy, std, and hiv in rural adolescents. j health commun. 12, 53-76. http://dx.doi.org/10.1080/10810730601096622 38. shepherd j, kavanagh j, picot j, cooper k, harden a, et al. (2010). the effectiveness and cost-effectiveness of behavioral interventions for the prevention of sexually transmitted infections in young people aged 13-19: a systematic review and economic evaluation. health technology assessment nihr hta program. [online] available from: http://www.hta.ac.uk [accessed on 07 july 2010]. 39. sionean c, diclemente r, wingood g, crosby r, cobb b, et al. 2002. psychosocial and behavioral correlates of refusing unwanted intercourse among african-american female adolescents. j adolesc health. 30, 55-63. http://dx.doi.org/10.1016/s1054-139x(01)00318-4 40. stephenson jm, strange v, allen e, copas a, johnson a, et al. 2008. the long-term effects of a peer-led sex education programme (ripple): a cluster randomised trial in schools in england. plos med. 5(11), e224. doi:http://dx.doi.org/10.1371/ journal.pmed.0050224. 41. stout pa, villegas j, kim h. 2001. enhancing learning through the use of interactive tools on health-related websites. health educ res. 16(6), 721-33. http://dx.doi.org/10.1093/ her/16.6.721 42. thomson r, holland j. (1998). sexual relationships, negotiation, and decision making. in coleman j and roker d (eds), teenage sexuality: health, risks, and education, 59-80. amsterdam: harwood. http://www.popcouncil.org/horizons/ortoolkit/aidsquest/topics/knowledge.html.%20%5baccessed%2020 http://www.popcouncil.org/horizons/ortoolkit/aidsquest/topics/knowledge.html.%20%5baccessed%2020 http://www.hta.ac.uk/ a controlled pre-post evaluation of a computer-based hiv/aids education on students’ sexual behaviors, knowledge and attitudes 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 43. tian l, tanga s, cao w, zhang k, li v, et al. 2007. evaluation of a web-based intervention for improving hiv/aids knowledge in rural yunnan, china. aids. 8, 137-42. http://dx.doi.org/10.1097/01.aids.0000304709.02412.3c 44. walker d, gutierrez jp, torres p, bertozzi sm. 2006. hiv prevention in mexican schools: prospective randomised evaluation of the intervention. bmj. doi:http:// dx.doi.org/10.1136/bmj.38796.457407.80. 45. wantland dj, portillo cj, holzemer wl, slaughter r, mcghee em. 2004. the effectiveness of web-based vs non-web-based interventions: a meta analysis of behavioral change outcomes. j med internet res. 6, e40. http://dx.doi.org/10.2196/jmir.6.4.e40 46. wight d, raab gm, henderson m, abraham c, buston k, et al. 2002. limits of teacher delivered sex education: interim behavioral outcomes from randomised trial. bmj. 324, 1430. http://dx.doi.org/10.1136/bmj.324.7351.1430 47. wikgren m. 2003. everyday health information exchange and citation behavior in internet discussion groups. new review of information behavior research. 4, 225-39. http:// dx.doi.org/10.1080/14716310310001631543 48. wyatt j, wyatt s. 2003. when and how to evaluate health information systems? int j med inform. 69, 251-59. http://dx.doi.org/10.1016/s1386-5056(02)00108-9 49. wyatt j. 2000. evaluating electronic consumer health materials. bmj. 320, 159-60. 50. biraro s, shafer la, kleinschmid i, wolff b, karabalinde a, et al. 2009. is sexual risk taking behavior changing in rural south-west uganda? behavior trends in a rural population cohort 1993-2006. sex transm infect. 85, i3-11. http://dx.doi.org/10.1136/ sti.2008.033928 51. young sd, rice e. 2011. online social networking technologies, hiv knowledge, and sexual risk and testing behaviors among homeless youth. aids behav. 15(2), 253-60. http://dx.doi.org/10.1007/s10461-010-9810-0 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts paralysis analysis: investigating paralysis visit anomalies in new jersey teresa hamby*1, stella tsai1, carol genese1, andrew walsh2, lauren bradford2 and edward lifshitz1 1nj department of health, trenton, nj, usa; 2health monitoring systems, inc, pittsburgh, pa, usa objective to describe the investigation of a statewide anomaly detected by a newly established state syndromic surveillance system and usage of that system. introduction on july 11, 2012, new jersey department of health (doh) communicable disease service (cds) surveillance staff received email notification of a statewide anomaly in epicenter for paralysis. two additional anomalies followed within three hours. since paralysis anomalies are uncommon, staff initiated an investigation to determine if there was an outbreak or other event of concern taking place. also at question was whether receipt of multiple anomalies in such a short time span was statistically or epidemiologically significant. methods in new jersey, 68 of 81 total acute care and satellite emergency departments (eds) are connected to epicenter, an online syndromic surveillance system developed by health monitoring systems, inc (hms) that incorporates statistical management and analytical techniques to process health-related data in real time. chief complaint text is classified, using text recognition methods, into various public health-related and other categories. anomalies occur when any of several statistical methods detect increases in incoming data that are outside of established thresholds. after receiving three anomaly notifications related to paralysis in a 4-hour time period, njdoh surveillance data staff enlisted cds and local epidemiologist colleagues to review the data and determine if there was an infectious cause. results the first epicenter anomaly notification was received on july 11, 2012 at 1:22 pm as a result of increased ed visits classified as paralysis based on facility location for the period beginning at noon on july 10, 2012. using cusum ema analysis, 76 reported interactions exceeded the predicted value of 50.49 and the threshold of 70.72. the second anomaly, also based on facility location, was received at 3:20 pm and the third anomaly notification, based on home location, was received at 4:32 pm. cusum ema and exponential moving average analysis methods detected these anomalies. table 1 describes the anomalies in more detail. compiled data from all anomalies were reviewed by cds epidemiology and surveillance staff to determine whether there was a public health event taking place. a total of 89 patients were seen in 39 (57%) of the 68 nj facilities reporting to epicenter with no geographic centralization. age and gender of patients were reviewed with no clear pattern discerned. figure 1 shows the time distribution of these visits. upon further investigation, it was determined that a moderate increase in paralysis visits over a relatively short time span was sufficient to create an anomaly under the default threshold for those visits. multiple analysis methods created multiple anomalies which gave an impression the event was of greater significance compared to a single anomaly. to follow up, njdoh requested that local epidemiologists investigate within their jurisdictions by contacting hospitals directly where epicenter data proved inconclusive. their reports confirmed njdoh’s findings that the anomalies did not signal an event of public health concern. conclusions this investigation of three paralysis anomalies is an important introduction to the newly implemented system’s capabilities in anomaly detection, and also to anomaly investigation procedures developed by njdoh for local surveillance staff. as a result of this experience, these anomaly investigation procedures are being fine-tuned. the fact that these sequential anomalies resulted in an investigation being undertaken highlights the importance in setting investigationgenerating alert thresholds within epicenter at a level that will minimize “false” positives without risking the missing of “true” positives. table 1: anomaly details keywords syndromic; surveillance; investigation acknowledgments nj lincs epidemiologists, nj doh epideimologists, nj doh surveillance staff *teresa hamby e-mail: teresa.hamby@doh.state.nj.us online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e126, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts computerized text analysis to enhance automated pneumonia detection sylvain delisle*1, 2, tariq siddiqui1, 2, adi gundlapalli3, 4, matthew samore3, 4 and leonard d’avolio5, 6 1va maryland health care system, baltimore, md, usa; 2medicine, university of maryland, baltimore, md, usa; 3va salt lake city health care system, salt lake city, ut, usa; 4university of utah, salt lake city, ut, usa; 5va boston health care system, boston, ma, usa; 6harvard medical school, boston, ma, usa objective to improve the surveillance for pneumonia using the free-text of electronic medical records (emr). introduction information about disease severity could help with both detection and situational awareness during outbreaks of acute respiratory infections (ari). in this work, we use data from the emr to identify patients with pneumonia, a key landmark of ari severity. we asked if computerized analysis of the free-text of clinical notes or imaging reports could complement structured emr data to uncover pneumonia cases. methods a previously validated ari case-detection algorithm (cda) (sensitivity, 99%; ppv, 14%) [1] flagged vamhcs outpatient visits with associated chest imaging (n = 2737). manually categorized imaging reports (non-negative if they could support the diagnosis of pneumonia, negative otherwise; kappa = 0.88), served as a reference for the development of an automated report classifier through machinelearning [2]. emr entries related to visits with non-negative chest imaging were manually reviewed to identify cases with possible pneumonia (new symptom(s) of cough, sputum, fever/chills/night sweats, dyspnea, pleuritic chest pain) or with pneumonia-in-plan (pneumonia listed as one of two most likely diagnoses in a physician’s note). these cases were used as reference for the development of the emr-based cdas. cda components included icd-9 codes for the full spectrum of ari [1] or for the pneumonia subset, text analysis aimed at non-negated ari symptoms in the clinical note [1] and the above-mentioned imaging report text classifier. results the manual review identified 370 reference cases with possible pneumonia and 250 with pneumonia-in-plan. statistical performance for illustrative cdas that combined structured emr parameters with or without text analyses are shown in the table. addition of the “text of imaging report” analyses increased ppv by 38-70% in absolute terms. despite attendant losses in sensitivity, this classifier increased the f-measure of all cdas based on a broad ari icd-9 codeset. with the possible exception is cda 6, whose f-measure was the highest achieved in this study, the text analysis seeking ari symptoms in the clinical note did not add further value to those cdas that also included analyses of the chest imaging reports. conclusions automated text analysis of chest imaging reports can improve our ability to separate outpatients with pneumonia from those with a milder form of ari. keywords situational awareness; influenza; surveillance; electronic medical record; pneumonia references [1] delisle s, south b, anthony ja, kalp e, gundlapalli a, et al. combining free text and structured electronic medical record entries to detect acute respiratory infections. plos one (2010) 5(10): e13377. [2] d’avolio l, nguyen t, goryachev s, fiore l. automated conceptlevel information extraction to reduce the need for custom software and rules development. journal of the american medical informatics association 2011 18(5): 607. *sylvain delisle e-mail: sdelisle@umaryland.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e74, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts eidss application for cchf foci activity epi-analysis and prediction in kazakhstan stanislav v. kazakov1, alexey v. burdakov*2, kenes s. ospanov3, aizhan s. esmagambetova4, andrey o. ukharov2, veronika p. sadovskaya1 and umirbek b. usenov3 1kazakh scientific center of quarantine and zoonotic diseases, almaty, kazakhstan; 2black & veatch, overland park, ks, usa; 3scientific center of sanitary and epidemiological expertise and monitoring, almaty, kazakhstan; 4committee of state sanitary and epidemiological surveillance of the ministry of health of kazakhstan, astana, kazakhstan objective test of the electronic integrated disease surveillance system (eidss) for epi-analysis and prediction of situation in cchf foci in kazakhstan. introduction cchf foci are reported in 3 southern regions of kazakhstan with population of 1 million. the ixodic ticks in the area are cchf carriers. human infections (3 to 12 cases per year) occur through tick bites and contact with cchf patient blood. cchf epidemiological process in kazakhstan has prominent seasonality (spring-summer period) and the rhythm of epidemic appearances (5-6-years). the rhythmical population incidence rate is associated with natural and climate factors, which govern the increase in the number of ixodic ticks, their infection rate (virus carrier state), and directly correlates with the population density and the livestock number that are the principal tick feeders in nature. methods eidss version 4 provides capability to collect, share and process epidemiological, clinical and laboratory data on infectious diseases in medicine, veterinary and environment sectors. it is currently deployed in kazakhstan at 150 sites of the ministry of agriculture (planned up to 271), and at 8 sites of the ministry of health (planned up to 23). three available indicators (for 2007-2011) were used for analysis: population; tick infection rate (relative density of cchf seropositive tick samples per total number of tested laboratory samples); cchf human case rate by districts per 10’000. the following procedure was conducted: 1) demographic information, diagnosis and location data entry into eidss 2) tick collection location data, total number of tested samples (pools), and number of seropositive data entry into eidss 3) correlation joint analysis of data on vectors and epidemiological surveillance in analysis, visualization and reporting (avr) module results eidss generated 12 different maps filtered according to the selected regions, ticks, demographics and cchf human incidence, aggregated by region, correlated by 3 indicators entered into the database. this allowed visualizing information to support epi-analysis. as a result, for each of the 3 regions specific districts with the highest risk of the cchf epidemic outbreaks were identified. the resulting information was grouped into 3 clusters of risk with the following criteria: population density, tick infection rate and human cases for each of 25 cchf-disadvantaged districts (see map). these results predict the epidemic situation in a particular area and support management decisions for planning and correction of preventive antitick and anti-epidemic measures and funding requirements. conclusions eidss with natural vectors and the avr modules has capabilities for analysis and prediction of epizootic and epidemic processes in vector-borne virus infections foci. it is an easy to use and free-ofcharge tool that can become the basic instrument for especially dangerous diseases field epidemiologists as well as for the ministries and local governments for cchf prophylaxis decision support. keywords cchf; one health; electronic disease surveillance; eidss; multi-factor analysis references 1. kazakov s.v., et.al. cchf causation model in the roitman’s ring graphs // hygiene, epidemiology and immunobiology, 2000, nos.34, pp.88-90 2. durumbetov e.e., et.al. practical application of epidemiological triad model for managerial decision-making within the system of episurveillance in moyinkum foci of cchf // proceedings of new technologies in medicine and pharmacy, astana 2001, pp.34-35 3. kazakov s.v., et.al. methodological approaches to study epidemic process of cchf in moyinkum foci of zhambyl region. // hygiene, epidemiology and immunobiology, 2001. nos.1-2, pp.75-84 4. onishchenko g.g., et.al. using ifa and rt-pcr in study of ixodic tick infection rate collected in cchf foci in kazakhstan and tajikistan in 2001-02. // virology matters. m., 2005. no.1 pp.23-27 5. ospanov k.s., kazakov s.v., et.al. on prospects of further study of cchf foci in kazakhstan // science and disease surveillance review, btrp, atlanta, 2009, p.126 6. burdakov a., ukharov a. transforming national human and veterinary disease surveillance systems from paper into integrated electronic form in the fsu countries // 15th international congress on infectious diseases (icid), bangkok 2012 *alexey v. burdakov e-mail: burdakovav@bv.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e109, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts new strategy to monitor and assess laboratory biosafety programs heather n. meeks1, betiel h. haile2, ngozi a. erondu2, lisa ferland2, meeyoung park2 and scott j. mcnabb*2, 3 1defense threat reduction agency, basic & applied sciences, fort belvoir, va, usa; 2public health practice, llc, atlanta, ga, usa; 3hubert department of global health, emory university, rollins school of public health, atlanta, ga, usa objective to develop a toolset to monitor and assess laboratory biosafety program performance and cost introduction laboratory biosafety – a component of biosecurity – has specific elements that together, comprise a facility’s capability to both protect employees and the surrounding public and environment. measuring these elements permits assessment and the costing of program-specific safety interventions. in the absence of a strategy and toolset, we developed a conceptual framework and toolset that monitors and assesses laboratory biosafety programs (lbps) and provides useful information (e.g., return on investment [roi]) for decision makers. methods we conducted academic and open source literature reviews of lbps and affiliated organizations laboratory manuals to identify objectives, goals, and indicators. these findings were aligned to laboratory biosafety-specific inputs, activities, outputs, and outcomes to create a strategic, conceptual framework (logic models) used to assess performance and measure the cost and roi. indicators were identified in existing literature or developed and mapped to the logic model elements. results six logic models were created: laboratory biosafety, biosurety, procedural, biocontainment, information security, and training. the laboratory biosafety logic model served as the overall framework for the remaining five sub-logic models. we also established a database containing 161 indicators mapped to each of the logic model elements. conclusions we developed a strategic framework that monitors and evaluates lbps. while evaluation of cost-impacts in lbps provides business intelligence for resource planning, this integrated approach also provides information about gaps. we plan to pilot this toolset and refine indicators using principal component analysis. keywords laboratory biosafety; evaluate laboratory; program performance acknowledgments defense threat reduction agency, basic & applied sciences references 1. bakanidze l, imnadze p, perkins d. biosafety and biosecurity as essential pillars of international health security and cross-cutting elements of biological nonproliferation. bmc public health. 2010;10 suppl 1:s12. 2. organization wh. international health regulations (2005) ihr monitoring framework: checklist and indicators for monitoring progress in the development of ihr core capacities in states parties. geneva; 2010. 3. carr k, henchal ea, wilhelmsen c, carr b. implementation of biosurety systems in a department of defense medical research laboratory. biosecurity and bioterrorism : biodefense strategy, practice, and science. 2004;2(1):7-16. epub 2004/04/08. 4. garaigordobil m. evaluation of a program to prevent political violence in the basque conflict: effects on the capacity of empathy, anger management and the definition of peace. gac sanit. 2012. epub 2012/01/31. 5. jahrling p, rodak c, bray m, davey rt. triage and management of accidental laboratory exposures to biosafety level-3 and -4 agents. biosecurity and bioterrorism : biodefense strategy, practice, and science. 2009;7(2):135-43. epub 2009/07/29. 6. le duc jw, anderson k, bloom me, estep je, feldmann h, geisbert jb, et al. framework for leadership and training of biosafety level 4 laboratory workers. emerging infectious diseases. 2008;14(11):1685. 7. lewis m, development cfg. governance and corruption in public health care systems: center for global development; 2006. 8. losinger wc, bush ej, hill gw, smith ma, garber lp, rodriguez jm, et al. design and implementation of the united states national animal health monitoring system 1995 national swine study. preventive veterinary medicine. 1998;34(2-3):147-59. 9. miller sr, bergmann d. biocontainment design considerations for biopharmaceutical facilities. journal of industrial microbiology & biotechnology. 1993;11(4):223-34. 10. murray cjl, evans db. health systems performance assessment: world health organization; 2003. *scott j. mcnabb e-mail: scottjnmcnabb@emory.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e165, 2013 improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project brian e. dixon 1 , kellie kaneshiro 2 1 regenstrief institute, indiana, indiana university school of informatics, dept. of veteran affairs, veterans health administration 2 indiana university school of medicine abstract background: human immunodeficiency virus and acquired immunodeficiency syndrome (hiv/aids) remains a significant international public health challenge. the statewide hiv/aids information network (shine) project was created to improve hiv/aids health information use and access for health care professionals, patients, and affected communities in indiana. objective: our objective was to assess the information-seeking behaviors of health care professionals and consumers who seek information on the testing, treatment, and management of hiv/aids and the usability of the shine project’s resources in meeting end user needs. the feedback was designed to help shine project members improve and expand the shine project’s online resources. methods: a convenience sample of health care professionals and consumers participated in a usability study. participants were asked to complete typical hiv/aids information-seeking tasks using the shine project website. feedback was provided in the form of standardized questionnaire and usability “think-aloud” responses. results: thirteen participants took part in the usability study. clinicians generally reported the site to be “very good,” while consumers generally found it to be “good.” health care professionals commented that they lack access to comprehensive resources for treating patients with hiv/aids. they requested new electronic resources that could be integrated in clinical practice and existing information technology infrastructures. consumers found the shine website and its collected information resources overwhelming and difficult to navigate. they requested simpler, multimedia-content rich resources to deliver information on hiv/aids testing, treatment, and disease management. conclusions: accessibility, usability, and user education remain important challenges that public health and information specialists must address when developing and deploying interventions intended to empower consumers and support coordinated, patient-centric care. keywords: hiv, acquired immunodeficiency syndrome, information seeking behavior, internet, public health informatics http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 introduction human immunodeficiency virus and acquired immunodeficiency syndrome (hiv/aids), a progressive disease that dismantles the human immune system and has no cure, remains one of the greatest international public health and health care challenges. the united nations estimates that 33 million people worldwide are living with hiv/aids (1). in the united states, while the number of new diagnoses of and deaths from aids are decreasing, the u.s. centers for disease control and prevention (cdc) reports that the number of people living with hiv/aids (plwha) is increasing (2). hiv/aids disproportionally affects minorities and men who have sex with men (1, 2). furthermore, plwha are more likely to be unemployed and/or poor and much more likely to be uninsured or dependent on public insurance programs such as medicaid (3). diagnosing, treating, and managing hiv/aids in the u.s. occurs in an increasingly fragmented health care ecosystem, presenting challenges for both health care providers and plwha. diagnosing patients remains problematic as our nation’s testing strategy often fails to reach those at most risk. hiv testing occurs primarily (44 percent) in private settings (e.g., physician practice), yet hospitals and emergency rooms (22 percent) and community clinics (9 percent) are the most likely places to find positive results (3). only five percent of hiv tests are performed in public health clinics, correctional settings, sexually transmitted diseases clinics, and drug treatment clinics. thirty nine us states offer anonymous testing, so even if testing occurs, it does not guarantee that a patient’s status will be known to his or her treating provider (4). even if a patient’s status is known, strict federal and state laws regarding disclosure of hiv/aids status (5) and the lack of a sophisticated electronic infrastructure for sharing test results (6, 7) make it difficult to share that knowledge with a treating physician in another practice. the result of a poor testing and restricted knowledge sharing is an estimated 500,000 patients who are not receiving care for their disease, of which approximately 250,000 do not know they are hiv positive (8). additionally, many individuals who receive a diagnosis of hiv infection late during the course of the disease are less likely to receive standard-of-care antiretroviral therapy (3). this challenge is compounded by a shortage of infectious disease specialists and primary care doctors. broad consensus exists that the care of plwha should be guided by an hiv expert. expert care has been associated with reduced morbidity, mortality, and cost of care (9-12). however, in a recent survey of hiv specialty clinics, only 15% indicated they could absorb a significant increase in patient load (13). these clinics reported a 30-70 percent increase in patient volume, yet only a handful had financial resources to hire more staff. while adept at providing a patchwork of services, state and local health departments often struggle to provide hiv prevention and care services due to inadequate funding, fragmented systems, and a host of federal and state regulations (14). these factors, combined with a general aging of the hivinfected population, have resulted in increased “mainstreaming” of plwha into primary care and generalist care practices, which places a greater knowledge burden on clinicians in primary and general care (15). the goal of the statewide hiv/aids information network (shine) project is to improve hiv/aids health information use and access for hiv/aids health care professionals, patients, http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 and affected communities in indiana. a national study of hiv care continuing education and consultation needs of health care professionals revealed that 64% of respondents cited quality of care or difficulties staying up-to-date as their main reason for their “unwillingness” to accept new patients with hiv or aids (16). the shine project attempts to make information resources available to clinicians (e.g., hiv experts, primary care, and generalists) to support increasingly complex clinical decision-making, including but not limited to the diagnosis of acute hiv infection, initiation of antiretroviral therapy (art), antiretroviral side effect awareness and monitoring, toxicity of antiretroviral agents, as well as routine primary care screening for diseases such as breast and prostate cancers for plwha. the shine project further attempts to make resources available directly to healthcare consumers, including plwha, and caregivers of plwha (e.g., family members, social workers, case managers). previous studies have documented the various methods by which plwha and their caregivers access information related hiv infection and aids. the previously identified methods include healthcare providers, print media, the internet, other plwha, education programs, and social networks (17-20). personal contacts, including healthcare providers, professional caregivers (e.g., social workers, case managers), and peers, have been cited as a preferred source of information for plwha. the internet is often a secondary source of information for plwha, yet professional caregivers are twice as likely to provide information from the internet or print something from the internet and give it to their patients (20). furthermore, plwha have reported that the myriad of sources provide an overwhelming, often confusing, and sometimes unscrupulous array of information that can be just as frustrating as it might be helpful (17, 18). finally, it has been documented that the information needs of plwha changes over time (21). plwha, often when first diagnosed, begin as sponges and seek to absorb as much information as possible about the disease, coping with life as someone infected, and available treatments and management of hiv/aids. as the disease progresses and/or the plwha advance in age, information needs shift away from absorption towards experiential knowledge exchange (21). to meet the needs of providers and consumers in indiana, the shine project created at website (http://library.medicine.iu.edu/shine) to serve as a statewide information and training resource. the site provides access to electronic information resources (e.g., journal articles, up-to-date guidelines, medlineplus®) that providers and consumers need to make informed hiv/aids testing, treatment, and quality of life decisions. the site further links users to inhealthconnect, a statewide database of educational and social services available to providers and consumers who desire to either learn more about hiv/aids treatment and care or gain access to counseling, shelter, and food. the shine project involved a public-private collaborative consisting of core team members from the indiana university school of medicine and regenstrief institute and an informal advisory board composed of individuals from hiv care providers, public health agencies, and hiv community organizations. to ensure that the site is both user-friendly and meets users’ needs, the shine team conducts periodic site evaluation. this article focuses on the results of recent usability testing, a common and recommended strategy for assessing a web site (22). from december 2009 through february 2010, the shine team held a series of usability testing sessions to gather detailed knowledge on the information needs of key, prioritized audiences: clinicians (e.g., those who treat patients with hiv/aids) and consumers (e.g., those at risk or living with hiv/aids). in http://library.medicine.iu.edu/shine http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 this paper, we present the lessons from the usability testing sessions as they have implications for the shine project and other public health initiatives that develop and deploy information resources for use by clinicians and consumers. methods participants an equal number of participants from each prioritized population were invited to participate. for usability testing, a population of 6-8 in each audience segment is a recommended best practice. the shine team attempted to recruit 8 clinicians and 8 consumers. clinicians were recruited primarily by email invitations sent through professional organizations, including the midwest aids training and education center (matec) indiana, a provider of hiv/aids education to physicians and nurses throughout the state, and the indiana rural health association (irha), a federation of nurses, physicians, social workers, and administrators working in indiana-based rural clinical settings. physicians practicing at sites near the indiana university school of medicine were also targeted. however, the shine team initially focused efforts on recruiting clinicians that were based outside of the indianapolis metropolitan area to ensure a representative mix of clinicians from around indiana. clinicians were not incentivized to participate in the usability testing. consumers were primarily recruited on site at hiv/aids service providers in indianapolis. one consumer approached the shine team staff via email in response to the call for clinician participation described above. consumer participants were selected through a convenience approach, and randomization was not utilized. these participants were offered a $10 grocery store gift certificate for participation. participants ranged between 23-62 years of age, and the mean participant age was 40.5 (n=13). nearly all of the participants felt they were both experienced web users and knowledgeable about the latest trends and research in hiv/aids. half of the clinicians who participated (n=3) were physicians. the remaining clinicians included nurses (n=2) and a licensed clinical social worker (lcsw). one of the physicians was an infectious disease specialist while the other two physicians were internists. settings participants completed the testing from a comfortable setting where they normally access the computer and internet. health care providers participated from their office workstation. the physician participants were in the same room with the facilitator at their normal workstation. the nurses and social worker were remotely tested using methods described previously by dixon (23). consumers were tested on a workstation at the service provider location. the consumer who approached us also participated remotely, but in this instance the facilitator followed the procedures as described by dixon (23) and the user simply interacted with the facilitator via speakerphone instead of an online conferencing tool. http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 study design this study was approved by the iupui-clarian institutional review board (irb), study #ex0911-15. each participant was provided with a one-page overview of the study that explained the methods and process used to capture their feedback regarding the shine website. upon reviewing the instructions, a study facilitator answered any participant questions then proceeded to assign the participants a series of tasks to complete using the shine website. participants were given tasks until either they completed all available tasks or 15 minutes had elapsed, whichever came first. the tasks were considered “normal” use cases for why an individual might come to the shine website. upon completing the assigned tasks, users were asked to complete a questionnaire about their experience interacting with the site. the primary instrument for measuring the user experience was the system usability scale (sus). the sus is a widely used and scientifically validated usability instrument (24). the sus produces a usability score between 0-100, based on respondents’ component scores. users were also asked about their general impressions of the site, recommended changes they had for the site developers, and other open-ended questions intended to capture qualitative feedback. the study facilitator took detailed notes while the users interacted with the site to complete their assigned tasks. users were encouraged to “think-aloud” while completing each task. the facilitator recorded participant’s comments, and the facilitator asked and recorded responses to follow-up questions. if a participant appeared to be stymied, facilitators were allowed to assist users, but facilitators were not allowed to “give away” the answer to the task at-hand or suggest where the user should click on the site to reach a destination. data analysis the quantitative sus scores were averaged to derive statistical mean scores which describe the general usability of the shine site. participants’ qualitative feedback included notes from the facilitator and open-ended responses from a post-test questionnaire. analysis involved a comparative method of continuously comparing important concepts within the collected data through a process where the authors collated, annotated, and discussed the data and their meaning. the authors looked for salient and recurring topics related to users’ information needs as well as satisfaction with the shine site. results usability scores the results from the usability testing provide data on how well the site supports a positive user experience. the sus values from the usability tests ranged from 40 95 with a mean sus score of 75.77 (n=13) – a “very good” score – and a standard deviation of 15.86. a comparison of providers to consumers reveals a clear distinction in sus scores. providers favored the site more than consumers. the mean sus score for providers (n=6) was 85.42 – an “excellent” score – with a standard deviation of 10.54. the mean sus score for consumers (n=7) was 67.50 – a “good” score – with a standard deviation of 15.41. http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 information seeking behaviors all of the participants reported spending a significant amount of time on the internet. the top named site of choice was google. the majority of participants were frequent visitors to online news sites, such as cnn, new york times, msn, and the indianapolis star. slightly more than half of the participants (n=8) were frequent visitors to social networking sites such as facebook and youtube. the clinicians varied widely in their readership of peer-reviewed journals and trade publications. journals specifically named by participants included the new england journal of medicine, journal of the american medical informatics association, annals of internal medicine, clinical infectious diseases, emergency nurses association journal, journal of forensic nursing, forensic examiner, and nurse management. however, clinicians reported reading journals on a sporadic basis due to time constraints. fewer than half of clinicians were regular readers of trade publications. for those clinicians who did read trade publications, e-newsletters were mentioned more frequently than paper-based periodicals. participants were asked to identify current sources they regularly consult when looking for information on hiv/aids. providers were evenly split between those who preferred to learn from a human being (e.g., ask a peer, attend an educational session) and those who were willing to search for information using an electronic resource such as medline. consumers were similarly divided. slightly more than half (n=4) of the consumers reported they turned to a human being (e.g., care coordinator, their doctor), while others said they learned by reading (e.g., brochures in their doctor’s office, the public health department’s website, email discussion lists for those living with hiv/aids). user satisfaction in addition to differences in the sus scores assigned by providers and consumers, there were differences in opinions between these groups when asked about their satisfaction with the site. clinicians the qualitative responses from clinicians complemented their quantitative scores. clinicians generally liked the site. most commented verbally that they would visit the site in the future. one of the clinicians said she was excited to share the site’s url with a colleague. none of the clinicians had used or knew about the site prior to the usability test. this made them a novice site user even though all but one labeled himself or herself an experienced internet user. clinicians quickly navigated to the “for clinicians” section, or clinician toolkit, when completing their assigned tasks. physicians in particular preferred this section of the site. the clinicians found the section easy to navigate. one clinician had trouble with the anchors/bookmarks, and the other clinicians tended to use the back button to move from a given section of the toolkit to the main list of categories. one clinician said verbally she felt that the toolkit allowed her to get close to what she needed in one-to-two clicks, which was ideal in her opinion. http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 several clinicians commented that the site, and the toolkit in particular, contained a “comprehensive” list of resources. one clinicians said she often receives emails from other sites about their resources but found this site to have several resources of which she was unaware. clinicians said they were likely to visit the site in the future. however, they cautioned that their return would be to perform a select list of actions. first, several clinicians expressed a desire for resources to pass along to their patients. physicians and nurses indicated the resources they would want for their patients include information on where they could go for testing, treatment, and support groups. one resource of particular interest was a site where the physician could find information on who to refer their patient when the patient moves out of the area. this included resources inside and outside the state. the social worker said she also desired resources for her patients that included follow-up services, including financial assistance, medical assistance, and help with nutrition. clinicians further indicated a desire for up-to-date access to information on post-exposure prophylaxis (pep). pep for exposure in the workplace has been a cdc recommended practice since the 1990s (25-27), and in 2005 the cdc expanded its recommendations to include nonwork related exposures (28). while the cdc recommendations are available online through google, pubmed, and other public websites, the guidelines are dense and complex which does not lend itself to quick decision-making in clinical practice. furthermore, the guidelines do not reflect the latest in research and development of antiviral medications, side effects, or the challenges and interactions with co-morbidities and other medications. clinicians who participated in this study requested an easy, quick, and up-to-date reference online for making decisions for their patients. finally, clinicians said they desired information on prophylaxis, including what clinicians should do when treating other sexually transmitted infections (stis) and common reactions between stis and retroviral medications. one physician mentioned that he currently uses a printed resource regarding the appropriate time to initiate prophylaxis treatment. he suggested that this resource would be more useful if electronic and available “on the web” so he could access from wherever he might be when making clinical decisions. beyond these specific actions, clinicians indicated they generally discuss hiv/aids prevention, treatment, and post-exposure “best practices” with their colleagues and hospital administrators. they were unsure that the site would be used by clinicians to get a lot of information about guidelines because these are often provided by resources integrated into electronic health record (ehr) systems. consumers overall, consumers found useful resources on the site. however, the majority of consumers criticized the site for lacking organization and having a boring appearance. like the clinicians, consumers seemed to find the “for consumers” section, or consumer toolkit, quickly. two consumers, however, suggested that the shine team could improve the site to more easily direct consumers to the toolkit. once at the toolkit, consumers found a lot of information – sometimes an overwhelming amount of “technical” information (two users said the http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 site was too technical). consumers felt the site had credibility and useful information, even if it was difficult to read through pages of text. several consumers requested the site add more graphics or pictures to help draw users into the various parts of the consumer toolkit. consumers overwhelmingly indicated they would come back to the site to access the “latest information” on hiv/aids. most of the consumers specifically mentioned “medications” or “drugs” as the type of information they felt would be provided on the site. results of new studies and research were a close second choice. only one consumer pointed out that the site featured testing location information. this indicates that several of the consumers were likely hiv positive and would use the site to access information they could use for treatment and management of the disease. terminology was an issue for some consumers. one consumer didn’t understand the term “clinician.” another consumer didn’t understand the term “consumer.” two users said “medical encyclopedia” sounded like it was for physicians and not patients. two of the consumers felt uncomfortable using a computer. one of these consumers stated he only accesses the internet at the library and does not own a personal computer. in general, consumers felt the site was often too busy and required “too much reading.” they strongly preferred sites that used a lot of graphics. this is evident in their preferred websites. most of them simply used the web to access news and general information or engage in social networking. they expected a clean user interface similar to those of sites like cnn and facebook. discussion usability testing was performed with a convenience sample of providers and plwha to assess user information needs and satisfaction with a particular online resource. the resource was generally perceived as a valuable source of information, but participants’ information seeking needs and behaviors varied widely. the feedback from participants provided useful feedback that the shine project will use to improve its web site in the future. the feedback further suggests several lessons that may be useful for public health, informatics, and computing professionals who desire to create, enhance, or support the use of similar information systems and resources. below we discuss the implications of our findings for the public health informatics community, and we outline planned changes to the shine site. analysis of participants’ feedback validates previous work that has demonstrated the following aspects of information resource development are critical to meet the information needs of users: 1) accessibility; 2) usability; and 3) user education. accessibility clinicians and consumers reported that they often lack access to useful information resources when making decisions about the testing for, treatment of, and maintenance of hiv/aids. in one case, a consumer indicated he or she lacked physical access to a computer except through the http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 public library. in another instance, a clinician reported having access to the internet but his or her institution did not have access to a specific information resource. accessibility challenges, however, are not a new phenomenon. it is well known that plwha are more likely to be socio-economically disadvantaged, and there exists a significant digital divide with respect to personal computers and internet access (29, 30). furthermore, it is known that many small and rural hospitals as well as physician practices often lack access to journals and other medical information resources (31-33). participant feedback in this study demonstrates that these kinds of accessibility issues were present in our sample, and they continue to be a challenge for clinicians and plwha who are most at-risk. in addition to general accessibility issues, clinicians in this study reported a lack of access to a specific resource they felt would be useful for treating plwha. these clinicians expressed a desire for an electronic referral tool to support coordinated care for plwha. the infectious disease specialist indicated an electronic referral tool would help her refer patients to primary care physicians who could support hiv/aids management. the internists indicated they desired a referral tool for help in finding the limited number of specialists who could best serve their patients. given the general trend towards mainstreaming plwha to primary care and general practice clinicians, the feedback suggests that electronic tools for supporting bi-directional referrals and communications for plwha may warrant further informatics investigation. the comments confirm earlier research that shows general and specialty practices are limited in the number of hiv/aids patients they can handle, and mechanisms for coordinating care across a fragmented health system are necessary to support caring for hiv/aids patients that are living longer and managing a complex disease (13, 15). given that the participating physicians in this study practice in advanced, urban health systems that utilize highly integrated information systems suggests that additional research and development may be necessary to support the national aims of better care coordination and patient-centered outcomes. electronic referral tools, for example, have been shown to improve the transfer of administrative and clinical information (34), reduce duplicate test-ordering (35), and improve both the referring and subspecialty physician’s ability to make treatment decisions (36). this is true not only in urban areas but also in safety net providers (37). beyond reporting a lack of accessibility to certain resources, participant feedback demonstrates that clinicians and plwha generally have access to a wide range of information sources that might contain knowledge about hiv/aids testing, treatment, or management. clinicians indicated using human and technology resources to find answers to their questions about hiv/aids. larger studies have suggested that clinicians use a wide range of sources but generally prefer to rely on colleagues to answer most of their questions about patient care (38, 39). this is due, in part, to access their peers’ tacit knowledge, although there is evidence that the most likely reason is that of practicality. asking a colleague in the office is quicker than searching for an answer in a book, journal, or information system. this is true even when clinicians are provided access to resources with higher quality information, suggesting that accessibility trumps quality in real-world, busy clinical practice settings (40). http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 consumers in this study also identified a wide range of sources used to access hiv/aids information, something demonstrated in several other studies on consumer access to hiv/aids information (41, 42). many of the sources indicated by consumers were part of the mass media, the predominant source of hiv/aids information for consumers in other studies (43, 44). these data suggest that consumers, like clinicians, generally choose sources based on their accessibility. mass media and human beings are more available than specialized, targeted online resources focused on hiv/aids testing, treatment, and disease management. therefore information resources need to be made available when and where clinicians and consumers are asking questions and making decisions. resources for clinicians integrated in applications already in use by clinicians, such as electronic health record (ehr) systems, might make more sense than a standalone resource available only through a google search. resources for consumers available as web sites, mobile phone applications, and accessible through personal health record (phr) systems may be a better approach than a traditional standalone internet site. usability common feedback from patients and caregivers in this study included statements like the shine site is “overwhelming,” “intimidating,” and “boring.” furthermore, consumers, on average, scored the site a 67.5 on the sus. the comments and ratings suggest that the shine site should be enhanced to better meet users’ information needs. the feedback is also in line with previous studies that have examined end user information needs. these studies found that patients and caregivers generally express feeling overwhelmed by the volume of information available on the web (45, 46). the studies’ authors suggest creating a resource that identifies the important web links or “quick tips” for end users, reducing their need to scan pages of search results. this is what the shine site attempts to do, index available, high quality information on hiv/aids for quick reference by providers, consumers, and caregivers. therefore similar feedback obtained in this study suggests that a usable web site is much more than just a resource that can distill thousands of search results into a convenient index. usable web sites are those that can connect users to the information they seek in efficient ways that support user workflows, preferences, and cognitive understanding of the information. the feedback from clinicians in this study suggests that the site supports clinician’s cognitive models of hiv and care delivery, but the site fails to meet clinician workflow or the reality of a busy practice setting. consumer and caregiver, on the other hand, workflows were supported by the site, but the site did not present information in a way that met their cognitive understanding of hiv/aids or resources for plwha. nor did the site support consumers’ preferences for splashy landing pages and highly graphical interfaces often found on mass media sites. specifically consumers complained that the site contains “too much text” and requires “a lot of reading.” when asked how to improve the site, consumers responded that it needed more “color,” “graphics,” “multimedia” content, “web 2.0” applications, and words that “pop.” these comments suggest that users with limited health literacy had difficulty approaching the site’s content and interpreting the resources indexed on the site. approximately one-third of patients in the united states have limited health literacy.(47) these patients have difficulties correctly reading basic items commonly encountered in the health care setting, such as prescription drug warning labels, appointment slips, and health education http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 materials. despite readability concerns, materials created for patients continue to be written at too high a level for the average american, and they are incomprehensible to those with limited health literacy (48, 49). this includes patient handouts, materials provided through an ehr system, and material generally available on the internet (49-52). information resources for consumers and caregivers need to be accurate, accessible, and actionable. currently the shine team includes a medical librarian and a graduate student in public health who evaluate and select information links on the consumer portion of the site. the team further performs periodic examinations, like the one detailed in this report, of the site to ensure accessibility and ease of use. the results suggest that the team also needs to screen the site and its contents for readability. otherwise, consumers and caregivers may be able to access the site and find resources that will support their information needs, but they may not be able to fully understand the content or act upon it (e.g., make informed decisions about their health). currently there are no widely accepted methods for determining whether health information resources are accurate, accessible, and actionable. such methods should be developed by the research community, so information system designers and implementers can put them to use for consumer materials on web sites and other health information systems. meanwhile, system developers and implementers can apply best practices from the printed material world to their products (53). user education in addition to strengthening accessibility and usabilty, user feedback demonstrates that the shine team needs to provide better education with respect to the availability of the site and how the site can be used to improve health care decision-making and quality of life for plwha. the clinicians and consumers participating in this study had never heard of the shine site prior to the study despite their recruitment through key partner organizations that have helped inform the development of the site and its contents. the shine team therefore needs to do more outreach with its partners and the community to make plwha, clinicians, and the general public more aware of resources to support the prevention, testing, treatment, and maintenance of hiv/aids. educating clinicians about the existence of shine is especiall important, because clinicians are generally unaware or unfamiliar with health information tools available for use by their patients (33). by educating clinicians about resources available for use by plwha, we may be able to increase clinician recommendation for their hiv/aids patients to access the site and benefit from the resources contained therein. several clinicians, especially nurses and social workers, in this study commented that they would indeed be willing to share the shine site information with their patients. in combination with presentations at hiv/aids shelters and treatment facilities, educating the wide specture of care providers for plwha might improve adoption and use of the shine site by those who have a need for the information on the site. outreach and education, however, should not just be limited to an awareness of the website and its contents. a recent literature review that examined clinician search behavior concluded that providers may not be equipped with the skills for effective use of information resources that are available to them (39). outreach librarians, as well as others invested in seeing clinicians utilize http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 information resources to improve patient outcomes, need to do more to educate health professionals on locating, accessing, and utilizing health information resources. established through the medical library assistance act of 1965, the national network of libraries of medicine member libraries and information centers provide health professionals and the general public with health information resources and services (54). services include education on effective search techniques and applying health information to decision-making processes. some of these medical libraries have outreach librarians who not only work directly with health professionals and consumers but also librarians at non-medical libraries to enhance resources available to the general public. studies have shown that professionally led library services have an impact on health outcomes for patients and may lead to time savings for healthcare professionals (55). yet it remains unclear how often these services are utilized. furthermore, health professionals and consumers cannot be forced to use library resources or services. additional interventions within libraries, as well as interventions from other groups such as professional societies, ehr implementation teams, consumer advocacy groups, and informatics programs, might improve providers and consumers’ access and comprehension of health information resources available to them. in addition to outreach and education about shine and how to use the site’s contents to make informed health care decisions, the shine team should explore ways to integrate consumerfocused resources into the ehr systems in use by clinicians throughout central indiana. currently there is little knowledge about ehr systems’ support for such “patient education materials.” however, requirements of the u.s. centers for medicare and medicaid services (cms) ehr incentive program for hospitals and physician practices include making consumerfocused materials available to patients during a clinical encounter (56). in support of this requirement, the u.s. national library of medicine (nlm) launched an initiative to integrate medlineplus resources into ehr systems and patient portals (57). additional research and development work will likely be necessary to fully integrate patient materials available from public health information resources like shine into ehr systems and patient portals, but doing so will support greater clinician access to (and possibly prescription for) materials that can meet the information needs of plwha. limitations participants were selected using convenience and non-randomized methods. therefore the sample populations represented in the usability testing may not reflect the general population of clinicians and plwha. the sample sizes were small, which is appropriate for usability testing but makes generalization of the findings to larger populations difficult. preferences for a website that disseminates information resources about hiv/aids in indiana may not reflect the desires of clinicians and patients in other u.s. states or other nations. conclusion a number of factors are moving health care delivery processes to be more patient-centric and consumer-driven in which the patient plays a stronger decision-making role in his or her care. in such a world, higher quality care and outcomes requires clinicians to understand disease and medicine as well as strategies for engaging consumers in self-management. sites like shine http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 aim to provide information resources to consumers and clinicians to support and enhance communication and collaboration between patient and providers. however, access to information is just one part of the equation. shine must also meet the needs of plwha, over time, as they age with hiv/aids and their health status changes. shine must further consider the health literacy needs of plwha and others who access the site in support of caring for plwha. this includes clinicians who require access to patient-focused educational materials as well as information on social, nutritional, and other community resources that support care for the whole person. this is not easy, and the usability testing reveals that shine can do more to meet its aims. the testing does show, however, that progress is being made and reveals insights for other public health, clinical, and informatics professionals also striving to make patientcentric and consumer-driven health care a reality. we hope the lessons from shine support the development of a wide range of informatics applications that better support plwha, caregivers, clinicians, and others living with a chronic illness. acknowledgements the authors would like to thank michael wilkinson, mls, and john d. patton for their dedication to the shine project and its mission. they further thank mr. patton for his role in assisting in the collection of data for the study described here. the authors also thank julie j. mcgowan, phd, for her feedback on early drafts of this manuscript. the shine project is a project of the indiana university school of medicine library. this work was funded in part by the national library of medicine, national institutes of health, u.s. department of health and human services under purchase order no. hhsn276200800492p. the views expressed in this article are those of the authors and do not necessarily represent the views of the national library of medicine, national institutes of health, department of health and human services, or department of veterans affairs. conflicts of interest the authors declare that they have no conflicts of interests. correspondence brian e. dixon, mpa, phd research scientist regenstrief institute, inc. 410 west 10th street, suite 2000 indianapolis, in 46202-3012 317-423-5582 (phone) 317-423-5695 (fax) email: bdixon@regenstrief.org mailto:bdixon@regenstrief.org http://ojphi.org improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 references 1. joint united nations programme on hiv/aids (unaids). 2008. report on the global aids epidemic. mexico city. 2008, jc1510e. 2. centers for disease control and prevention. hiv/aids surveillance report, 2007; 2009 [cited 2010 may 8]; 19. available from: http://www.cdc.gov/hiv/topics/surveillance/resources/reports/. 3. kates j, levi j. 2007. insurance coverage and access to hiv testing and treatment: considerations for individuals at risk for infection and for those with undiagnosed infection. clin infect dis. 45(suppl 4), s255-60. epub 02 2008. http://dx.doi.org/10.1086/522547 4. kates j, penner m, kern d, carbaugh a, ginsburg b, et al. the national hiv prevention inventory: the state of hiv prevention across the u.s. menlo park, ca: nastad and the kaiser family foundation, 2009. 5. health resources and services administration. protecting health information privacy and complying with federal regulations2004 june 28, 2010. available from: ftp://ftp.hrsa.gov/hab/hipaa04.pdf. 6. silk bj, berkelman rl. 2005. a review of strategies for enhancing the completeness of notifiable disease reporting. j public health manag pract. 11(3), 191-200. epub 04 2005. http:// dx.doi.org/10.1097/00124784-200505000-00003 7. overhage jm, grannis s, mcdonald cj. 2008. a comparison of the completeness and timeliness of automated electronic laboratory reporting and spontaneous reporting of notifiable conditions. am j public health. 98(2), 344-50. epub 01 2008. http://dx.doi.org/10.2105/ajph.2006.092700 8. glynn mk, rhodes p, kajese t, eds. changes in the estimated number of persons diagnosed and living with hiv from 2000 to 2003 in the united states. program and abstracts of the 12th conference on retroviruses and opportunistic infections; 2005; boston, ma. 9. kitahata mm, koepsell td, deyo ra, maxwell cl, dodge wt, et al. 1996. physicians' experience with the acquired immunodeficiency syndrome as a factor in patients' survival. n engl j med. 334(11), 701-06. epub 03 1996. http://dx.doi.org/10.1056/nejm199603143341106 10. kitahata mm, van rompaey se, shields aw. 2000. physician experience in the care of hiv-infected persons is associated with earlier adoption of new antiretroviral therapy. j acquir immune defic syndr. 24(2), 106-14. epub 08 2000. http://dx.doi.org/10.1097/00126334-200006010-00004 11. kitahata mm, van rompaey se, dillingham pw, koepsell td, deyo ra, et al. 2003. primary care delivery is associated with greater physician experience and improved survival among persons with aids. j gen intern med. 18(2), 95-103. epub 01 2003. http://dx.doi.org/10.1046/j.1525-1497.2003.11049.x 12. landon be, wilson ib, mcinnes k, landrum mb, hirschhorn lr, et al. 2005. physician specialization and the quality of care for human immunodeficiency virus infection. arch intern med. 165(10), 1133-39. epub 05 2005. http://dx.doi.org/10.1001/archinte.165.10.1133 13. saag ms. 2007. opt-out testing: who can afford to take care of patients with newly diagnosed hiv infection? clin infect dis. 45(suppl 4), s261-65. epub 02 2008. http://dx.doi.org/10.1086/522548 14. penner m, leone pa. 2007. integration of testing for, prevention of, and access to treatment for hiv infection: state and local perspectives. clin infect dis. 45(suppl 4), s281-86. epub 02 2008. http:// dx.doi.org/10.1086/522551 15. gallant je. 2010. what does the generalist need to know about hiv infection? adv chronic kidney dis. 17(1), 5-18. epub 12 2009. http://dx.doi.org/10.1053/j.ackd.2009.08.003 16. liljestrand p. 2004. hiv care: continuing medical education and consultation needs of nurses, physicians, and pharmacists. j assoc nurses aids care. 15(2), 38-50. epub 04 2004. http:// dx.doi.org/10.1177/1055329003252053 http://www.cdc.gov/hiv/topics/surveillance/resources/reports/ ftp://ftp.hrsa.gov/hab/hipaa04.pdf http://ojphi.org http://www.cdc.gov/hiv/topics/surveillance/resources/reports/.3 http://www.cdc.gov/hiv/topics/surveillance/resources/reports/.3 http://dx.doi.org/10.1086/5225474 http://dx.doi.org/10.1086/5225474 ftp://ftp.hrsa.gov/hab/hipaa04.pdf.6 ftp://ftp.hrsa.gov/hab/hipaa04.pdf.6 http://dx.doi.org/10.1097/00124784-200505000-000037 http://dx.doi.org/10.1097/00124784-200505000-000037 http://dx.doi.org/10.1097/00124784-200505000-000037 http://dx.doi.org/10.2105/ajph.2006.0927008 http://dx.doi.org/10.2105/ajph.2006.0927008 http://dx.doi.org/10.1056/nejm19960314334110610 http://dx.doi.org/10.1056/nejm19960314334110610 http://dx.doi.org/10.1097/00126334-200006010-0000411 http://dx.doi.org/10.1097/00126334-200006010-0000411 http://dx.doi.org/10.1046/j.1525-1497.2003.11049.x12 http://dx.doi.org/10.1046/j.1525-1497.2003.11049.x12 http://dx.doi.org/10.1001/archinte.165.10.113313 http://dx.doi.org/10.1001/archinte.165.10.113313 http://dx.doi.org/10.1086/52254814 http://dx.doi.org/10.1086/52254814 http://dx.doi.org/10.1086/52255115 http://dx.doi.org/10.1086/52255115 http://dx.doi.org/10.1086/52255115 http://dx.doi.org/10.1053/j.ackd.2009.08.00316 http://dx.doi.org/10.1053/j.ackd.2009.08.00316 improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 17. benotsch eg, kalichman s, weinhardt ls. 2004. hiv-aids patients' evaluation of health information on the internet: the digital divide and vulnerability to fraudulent claims. j consult clin psychol. 72(6), 1004-11. epub 12 2004. http://dx.doi.org/10.1037/0022-006x.72.6.1004 18. hogan tp, palmer cl. 2005. information preferences and practices among people living with hiv/aids: results from a nationwide survey. j med libr assoc. 93(4), 431-39. 19. veinot tc. 2009. interactive acquisition and sharing: understanding the dynamics of hiv/aids information networks. j am soc inf sci technol. 60(11), 2313-32. http://dx.doi.org/10.1002/asi.21151 20. horvath kj, courtenay-quirk c, harwood e, fisher h, kachur r, et al. 2009. using the internet to provide care for persons living with hiv. aids patient care stds. 23(12), 1033-41. epub 12 2009. 21. minion j, bath p, albright k. from sponge to source: health information in the lives of gay men living with hiv. 8th global conference making sense of health, illness and disease; mansfield college, oxford, united kingdom2009, july 3-5. 22. wood fb, siegel er, lacroix e-m, lyon bj, benson da, et al. 2003. a practical approach to egovernment web evaluation. it prof. 5(3), 22-28. http://dx.doi.org/10.1109/mitp.2003.1202231 23. dixon be. enhancing the informatics evaluation toolkit with remote usability testing. amia annu symp proc. 2009;2009:147-51. epub 2009/01/01. 24. brooke j. sus a quick and dirty usability scale. in: jordan pw, thomas b, mcclelland il, weerdmeester b, editors. usability evaluation in industry. bristol, pa: taylor and francis ltd; 2003. p. 189-92. 25. from the centers for disease control and prevention. 1996. update: provisional public health service recommendations for chemoprophylaxis after occupational exposure to hiv. jama. 276(2), 90-92. epub 07 1996. http://dx.doi.org/10.1001/jama.1996.03540020012007 26. 1996. update: provisional public health service recommendations for chemoprophylaxis after occupational exposure to hiv. mmwr morb mortal wkly rep. 45(22), 468-80. epub 06 1996. 27. panlilio al, cardo dm, grohskopf la, heneine w, ross cs. 2005. updated u.s. public health service guidelines for the management of occupational exposures to hiv and recommendations for postexposure prophylaxis. mmwr recomm rep. 54(rr-9), 1-17. epub 10 2005. 28. smith dk, grohskopf la, black rj, auerbach jd, veronese f, et al. 2005. antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to hiv in the united states: recommendations from the u.s. department of health and human services. mmwr recomm rep. 54(rr-2), 1-20. epub 01 2005. 29. denning p, dinenno e. communities in crisis: is there a generalized hiv epidemic in impoverished urban areas of the united states? atlanta, ga: centers for disease control and prevention; 2010 [updated august 6; cited 2010 september 2]; available from: http://www.cdc.gov/ hiv/topics/surveillance/resources/other/poverty.htm. 30. kalichman sc, eaton l, cain d, cherry c, pope h, et al. 2006. community-based internet access for people living with hiv/aids -bridging the digital divide in aids care. j hiv aids soc serv. 5(1), 21-38. http://dx.doi.org/10.1300/j187v05n01_03 31. dee c, blazek r. 1993. information needs of the rural physician: a descriptive study. bull med libr assoc. 81(3), 259-64. epub 07 1993. 32. winters ca, lee hj, besel j, strand a, echeverri r, et al. 2007. access to and use of research by rural nurses. rural remote health. 7(3), 758. epub 09 2007. 33. andrews je, pearce ka, ireson c, love mm. 2005. information-seeking behaviors of practitioners in a primary care practice-based research network (pbrn). j med libr assoc. 93(2), 206-12. epub 04 2005. http://www.cdc.gov/hiv/topics/surveillance/resources/other/poverty.htm http://ojphi.org http://dx.doi.org/10.1037/0022-006x.72.6.100418 http://dx.doi.org/10.1037/0022-006x.72.6.100418 http://dx.doi.org/10.1002/asi.2115120 http://dx.doi.org/10.1002/asi.2115120 http://dx.doi.org/10.1109/mitp.2003.120223123 http://dx.doi.org/10.1109/mitp.2003.120223123 http://dx.doi.org/10.1001/jama.1996.0354002001200726 http://dx.doi.org/10.1001/jama.1996.0354002001200726 http://www.cdc.gov/hiv/topics/surveillance/resources/other/poverty.htm.30 http://www.cdc.gov/hiv/topics/surveillance/resources/other/poverty.htm.30 http://www.cdc.gov/hiv/topics/surveillance/resources/other/poverty.htm.30 http://dx.doi.org/10.1300/j187v05n01_0331 http://dx.doi.org/10.1300/j187v05n01_0331 improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 34. shaw lj, de berker da. 2007. strengths and weaknesses of electronic referral: comparison of data content and clinical value of electronic and paper referrals in dermatology. br j gen pract. 57(536), 223-24. epub 03 2007. 35. hunt dl, haynes rb, hanna se, smith k. 1998. effects of computer-based clinical decision support systems on physician performance and patient outcomes: a systematic review. jama. 280(15), 1339-46. epub 10 1998. http://dx.doi.org/10.1001/jama.280.15.1339 36. medow ma, wilt tj, dysken s, hillson sd, woods s, et al. 2001. effect of written and computerized decision support aids for the u.s. agency for health care policy and research depression guidelines on the evaluation of hypothetical clinical scenarios. med decis making. 21(5), 344-56. epub 09 2001. http://dx.doi.org/10.1177/0272989x0102100501 37. kim y, chen ah, keith e, yee hf, jr, kushel mb. 2009. not perfect, but better: primary care providers' experiences with electronic referrals in a safety net health system. j gen intern med. 24(5), 614-19. epub 03 2009. http://dx.doi.org/10.1007/s11606-009-0955-3 38. dawes m, sampson u. 2003. knowledge management in clinical practice: a systematic review of information seeking behavior in physicians. int j med inform. 71(1), 9-15. epub 08 2003. http:// dx.doi.org/10.1016/s1386-5056(03)00023-6 39. younger p. 2010. internet-based information-seeking behaviour amongst doctors and nurses: a short review of the literature. health info libr j. 27(1), 2-10. epub 04 2010. http:// dx.doi.org/10.1111/j.1471-1842.2010.00883.x 40. gonzalez-gonzalez ai, dawes m, sanchez-mateos j, riesgo-fuertes r, escortell-mayor e, et al. 2007. information needs and information-seeking behavior of primary care physicians. ann fam med. 5(4), 345-52. epub 08 2007. http://dx.doi.org/10.1370/afm.681 41. wilkerson jm, smolenski dj, horvath kj, danilenko gp, simon rosser br. 2010. online and offline sexual health-seeking patterns of hiv-negative men who have sex with men. aids behav. 14(6), 1362-70. epub 08 2010. http://dx.doi.org/10.1007/s10461-010-9794-9 42. kalichman sc, cain d, cherry c, pope h, eaton l, et al. 2005. internet use among people living with hiv/aids: coping and health-related correlates. aids patient care stds. 19(7), 439-48. epub 08 2005. http://dx.doi.org/10.1089/apc.2005.19.439 43. bankole a, biddlecom a, guiella g, singh s, zulu e. 2007. sexual behavior, knowledge and information sources of very young adolescents in four sub-saharan african countries. afr j reprod health. 11(3), 28-43. epub 05 2008. http://dx.doi.org/10.2307/25549730 44. feldman bs, kark jd, zarka s, ankol o, letyagina v, et al. 2011. behavioral surveillance of knowledge about hiv/aids transmission and perceived need for additional knowledge in a national sample of young israeli men and women between 1993 and 2005. aids behav. 15(1), 193-203. epub 01 2010. http://dx.doi.org/10.1007/s10461-009-9657-4 45. o'grady l. 2008. meeting health information needs of people with hiv/aids: sources and means of collaboration. health info libr j. 25(4), 261-69. epub 12 2008. http://dx.doi.org/10.1111/ j.1471-1842.2007.00764.x 46. gage ea, panagakis c. 2011. the devil you know: parents seeking information online for paediatric cancer. sociol health illn. epub 08 2011. 47. gazmararian ja, baker dw, williams mv, parker rm, scott tl, et al. 1999. health literacy among medicare enrollees in a managed care organization. jama. 281(6), 545-51. epub 02 1999. http://dx.doi.org/10.1001/jama.281.6.545 http://ojphi.org http://dx.doi.org/10.1001/jama.280.15.133936 http://dx.doi.org/10.1001/jama.280.15.133936 http://dx.doi.org/10.1177/0272989x010210050137 http://dx.doi.org/10.1177/0272989x010210050137 http://dx.doi.org/10.1007/s11606-009-0955-338 http://dx.doi.org/10.1007/s11606-009-0955-338 http://dx.doi.org/10.1016/s1386-5056 http://dx.doi.org/10.1016/s1386-5056 http://dx.doi.org/10.1111/j.1471-1842.2010.00883.x40 http://dx.doi.org/10.1111/j.1471-1842.2010.00883.x40 http://dx.doi.org/10.1111/j.1471-1842.2010.00883.x40 http://dx.doi.org/10.1370/afm.68141 http://dx.doi.org/10.1370/afm.68141 http://dx.doi.org/10.1007/s10461-010-9794-942 http://dx.doi.org/10.1007/s10461-010-9794-942 http://dx.doi.org/10.1089/apc.2005.19.43943 http://dx.doi.org/10.1089/apc.2005.19.43943 http://dx.doi.org/10.2307/2554973044 http://dx.doi.org/10.2307/2554973044 http://dx.doi.org/10.1007/s10461-009-9657-445 http://dx.doi.org/10.1007/s10461-009-9657-445 http://dx.doi.org/10.1111/j.1471-1842.2007.00764.x46 http://dx.doi.org/10.1111/j.1471-1842.2007.00764.x46 http://dx.doi.org/10.1111/j.1471-1842.2007.00764.x46 improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 48. wilson m. 2009. readability and patient education materials used for low-income populations. clin nurse spec. 23(1), 33-40, quiz 1-2. http://dx.doi.org/10.1097/01.nur.0000343079.50214.31 49. gal i, prigat a. 2005. why organizations continue to create patient information leaflets with readability and usability problems: a n exploratory study. health educ res. 20(4), 485-93. http://dx.doi.org/10.1093/ her/cyh009 50. vallance jk, taylor lm, lavallee c. 2008. suitability and readability assessment of educational print resources related to physical activity: implications and recommendations for practice. patient educ couns. 72(2), 342-49. http://dx.doi.org/10.1016/j.pec.2008.03.010 51. friedman db, hoffman-goetz l, arocha jf. 2006. health literacy and the world wide web: comparing the readability of leading incident cancers on the internet. med inform internet med. 31(1), 67-87. epub 06 2006. http://dx.doi.org/10.1080/14639230600628427 52. berland gk, elliott mn, morales ls, algazy ji, kravitz rl, et al. 2001. health information on the internet: accessibility, quality, and readability in english and spanish. jama. 285(20), 2612-21. epub 05 2001. http://dx.doi.org/10.1001/jama.285.20.2612 53. eichner j, dullabh p. accessible health information technology (it) for populations with limited literacy: a guide for developers and purchasers of health it. rockville, md: agency for healthcare research and quality; 2007. 54. national network of libraries of medicine. about the national network of libraries of medicine (nn/ lm). 2006 [updated 27 july; cited 2010 august 6]; available from: http://nnlm.gov/about/. 55. weightman al, williamson j. 2005. the value and impact of information provided through library services for patient care: a systematic review. health info libr j. 22(1), 4-25. epub 04 2005. http:// dx.doi.org/10.1111/j.1471-1842.2005.00549.x 56. cms. medicare and medicaid programs; electronic health record incentive program; proposed rule. federal register [internet]. 2010 january 25, 2010 [cited 2010 january 25]; 75(8):[1844-92 pp.]. available from: http://frwebgate5.access.gpo.gov/cgi-bin/pdfgate.cgi?waisdocid=4736101841+0+2 +0&waisaction=retrieve. 57. national library of medicine. medlineplus connect. 2011 [updated 16 june 2011; cited 2011 october 20]; available from: http://www.nlm.nih.gov/medlineplus/connect/overview.html. glossary aids: acquired immunodeficiency syndrome art: antiretroviral therapy cdc: centers for disease control and prevention cnn: cable news network ehr: electronic health record hiv: human immunodeficiency virus http://nnlm.gov/about/ http://frwebgate5.access.gpo.gov/cgi-bin/pdfgate.cgi?waisdocid=4736101841+0+2+0&waisaction=retrieve http://frwebgate5.access.gpo.gov/cgi-bin/pdfgate.cgi?waisdocid=4736101841+0+2+0&waisaction=retrieve http://www.nlm.nih.gov/medlineplus/connect/overview.html http://ojphi.org http://dx.doi.org/10.1097/01.nur.0000343079.50214.3149 http://dx.doi.org/10.1097/01.nur.0000343079.50214.3149 http://dx.doi.org/10.1093/her/cyh00950 http://dx.doi.org/10.1093/her/cyh00950 http://dx.doi.org/10.1093/her/cyh00950 http://dx.doi.org/10.1016/j.pec.2008.03.01051 http://dx.doi.org/10.1016/j.pec.2008.03.01051 http://dx.doi.org/10.1080/1463923060062842752 http://dx.doi.org/10.1080/1463923060062842752 http://dx.doi.org/10.1001/jama.285.20.261253 http://dx.doi.org/10.1001/jama.285.20.261253 http://nnlm.gov/about/.55 http://nnlm.gov/about/.55 http://dx.doi.org/10.1111/j.1471-1842.2005.00549.x56 http://dx.doi.org/10.1111/j.1471-1842.2005.00549.x56 http://dx.doi.org/10.1111/j.1471-1842.2005.00549.x56 http://frwebgate5.access.gpo.gov/cgi-bin/pdfgate.cgi?waisdocid%ed%af%80%ed%b0%a04736101841%ed%af%80%ed%b0%8e0%ed%af%80%ed%b0%8e2%ed%af%80%ed%b0%8e0%ed%af%80%ed%b0%89waisaction%ed%af%80%ed%b0%a0retrieve.57 http://frwebgate5.access.gpo.gov/cgi-bin/pdfgate.cgi?waisdocid%ed%af%80%ed%b0%a04736101841%ed%af%80%ed%b0%8e0%ed%af%80%ed%b0%8e2%ed%af%80%ed%b0%8e0%ed%af%80%ed%b0%89waisaction%ed%af%80%ed%b0%a0retrieve.57 http://frwebgate5.access.gpo.gov/cgi-bin/pdfgate.cgi?waisdocid%ed%af%80%ed%b0%a04736101841%ed%af%80%ed%b0%8e0%ed%af%80%ed%b0%8e2%ed%af%80%ed%b0%8e0%ed%af%80%ed%b0%89waisaction%ed%af%80%ed%b0%a0retrieve.57 http://www.nlm.nih.gov/medlineplus/connect/overview.html improving access to hiv and aids information resources for patients, caregivers, and clinicians: results from the shine project 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 irha: indiana rural health association iupui: indiana university-purdue university indianapolis matec: midwest aids training and education center msn: microsoft network pep: post-exposure prophylaxis plwha: people living with hiv and aids shine: statewide hiv/aids information network sti: sexually transmitted infection sus: system usability scale http://ojphi.org public health informatics and the h1n1 pandemic public health informatics and the h1n1 pandemic 1 online journal of public health informatics * issn 1947-2579 * http://journals.uic.edu public health informatics and the h1n1 pandemic joseph lombardo, johns hopkins university applied physics laboratory on june 11th 2009, dr. margaret chan, director-general of the world health organization (who), announced that the influenza alert level was being raised from a phase 5 to phase 6 indicating the start of the 2009 pandemic. the pandemic resulted from a previously uncirculated strain of h1n1 influenza which spread rapidly in the spring of 2009. the second wave of the pandemic began as schools reopened in the late summer. at the time of the writing of this commentary, h1n1 was widely spread in 48 states and canada. due to the intensive surveillance and preparedness activities surrounding a rapidly spreading avian h5n1 influenza, the who and the centers for disease control and prevention, were able to closely monitor the progression of the h1n1 strain in the human population and initiate an accelerated vaccination program. this heightened activity comes at a time of reduced budgets for state and local health departments who have primary responsibility for monitoring and containment within their jurisdictions. as resources become more limited, public health workers are forced to focus their attention on the most urgent priorities. in order to effectively multi-task, public health must leverage new technologies to get more done with existing resources. public health informatics is an emerging field that has the potential to immediately support the ten essential public health services. automated case specific disease monitoring applications can now collect, analyze and present to the user information that would have taken days to assemble only a few years ago. applications such as essence, rods, and biosense have been able to monitor spread of h1n1 at state, local, and national levels. the internet has become an educational tool for informing the population on the latest research to maintain and improve health. the websites of local health departments, cdc, who, webmd, google and many others have all seen increased activity as primary caregivers seek information on how to protect their family members from h1n1. emerging knowledge repositories showcased at national conferences have demonstrated the ability to transparently provide public health alerts to clinicians during patient encounters. information is provided to support disease management while enhancing real-time monitoring. the internet provides a secure collaborative environment to support public health monitoring across jurisdictional boundaries. the distribute project creates a national view of h1n1 trends from data provided by public health agencies across the country that have the desire to collaborate with their counterparts in other jurisdictions. these are just a few public health informatics applications that support h1n1 containment. as the field of public health informatics expands, its researchers and developers must keep in mind the goal of translating their achievements into open environment so that their informatics products can be made available to public health practitioners when they are needed. traditionally, informatics tools are presented to the community at conferences and through journal articles. local public health funding limitations may restrict travel at conferences or membership in societies that publish articles in their journals. the online journal of public health informatics (ojphi) provides an open access vehicle that supports the presentation of the latest open source informatics tools to the public health community to support their translation to practice. as an open access communications vehicle to public health, articles published in ojphi could provide knowledge of open source informatics tools to help public health manage the next emerging health risk. u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) sunghee h. boté1* 1university of illinois at chicago, school of public health abstract objectives: in recent years, the devastating effects of u.s. opioid epidemic has been making news headlines. this report explores background information and trends on opioid misuse, overdose fatalities and its impact on public health. in addition, various efforts to improve surveillance, timeliness of data and prescription drug monitoring program (pdmp) integration and interoperability are reviewed. method: pubmed and internet searches were performed to find information on the u.s. opioid epidemic. in addition, searches were performed to retrieve information about pdmps and state-specific mandates along with presentation slides and learnings from the 2018 national rx drug abuse & heroin summit in atlanta, ga. results: it is clear that the u.s. opioid epidemic has a tremendous impact on public health including the next generation of children. various data, surveillance & technology-driven efforts including cdcfunded enhanced state opioid overdose surveillance program (esoos) and use of telemedicine for opioid use disorder treatment aim to improve prevention, treatment and targeted interventions. in addition, pdmp integration and interoperability efforts are advancing to provide prescribers meaningful decision support tools. discussion: the opioid epidemic has a complex impact on public health intertwined with variable factors such as mental health and social determinants of health. given the statistics and studies that suggest many of the illicit opioid users start with prescription opioids, continued advancement in the area of pdmp integration and interoperability is necessary. the pdmp integrated clinical decision support systems need to supply to healthcare providers access to complete, timely and evidence-based information that can meaningfully inform prescribing decisions and communication with patients that affect measurable outcomes. conclusion: while prescription drug monitoring programs (pdmps) are valuable tools for providers in making informed prescribing decisions, the variable state mandates and varying degrees of integration and interoperability across states may limit their potential as meaningful decision support tools. sharing best practices, challenges and lessons learned among states and organizations may inform strategic and systematic use of pdmps to improve public health outcomes. key words: opioid epidemic, prescription drug monitoring programs (pdmps), prescription monitoring programs (pmps) u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi * corresponding author: email: sungheebote@gmail.com doi: 10.5210/ojphi.v11i2.10113 copyright ©2019 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. 1 introduction the opioid epidemic in the united states was declared a national public health emergency on october 26, 2017 [1]. according to the centers for disease control and prevention (cdc), approximately 130 americans die from an opioid overdose each day [2], and 46 overdose deaths involve prescription opioids [3]. the death toll from legal and illegal opioid use increased 6-fold between 1999 and 2017 [2]. opioids accounted for approximately 68% of all drug overdose deaths in 2017 [2], and 35% of all opioid deaths involved prescription opioids such as methadone, oxycodone and hydrocodone [3]. drug overdose death rate increased 137% between 2000 and 2014 which includes 200% increase in overdose deaths involving heroin and prescription opioids indicated for treatment of pain [4]. in a study analyzing emergency department syndromic and billing data, there was a 29.5% increase in opioid overdoses in 52 areas in 45 states from july 2016 to september 2017 and a 69.7% increase in opioid overdoses in the midwestern region during the same time period [5]. additionally, large cities in 16 states experienced an opioid overdose increase of 54.1% [5]. prescription opioids are generally used to treat moderate to severe pain, and some opioids can be used for treatment of diarrhea or cough [6]. common prescription opioids are codeine, morphine, hydrocodone, oxycodone, oxymorphone and fentanyl [6]. opioids are highly addictive, and overdose can lead to respiratory depression that can result in permanent brain damage, coma or death [6]. naloxone is a medication that can reverse opioid overdose when administered right away [6]. over 191 million opioid prescriptions indicated for the treatment of moderate to severe pain were dispensed in the u.s. in 2017 with wide variability among states [7]. this variability is not reflective of health status of the state [7]. additionally, the increase in the amount of opioids dispensed in the u.s. since the 1990s does not reflect the amount of pain americans report [7]. some risk factors identified for prescription opioid abuse and overdose include: receiving overlapping prescriptions using multiple prescribers and pharmacies, high daily doses of opioids, mental health disorder or history of substance abuse, and low income in rural settings [7]. heroin is an illegal semi-synthetic opioid drug. it is estimated that approximately two out of 1,000 people in the u.s. used heroin in 2017, and the most notable increases of heroin use are in women, privately insured and higher income population [8]. unintentional heroin-related poisoning accounted for 81,326 of emergency department visits in 2015, and drug overdoses involving heroin claimed 15,000 lives in the u.s. in 2017 [8]. the most prominent risk factor for heroin use is u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi history of prescription opioid misuse [9]. according to the cdc, 75% of new heroin users between 2000 and 2013 reported prior misuse of prescription opioids [8]. fentanyl is a synthetic opioid which is 50 to 100 times more potent than morphine and is available as a prescription drug for the treatment of severe pain such as cancer pain [10]. while it is possible prescription fentanyl can be misused and abused, there has been a growing concern about illicit fentanyl and its analogs distributed through illegal drug markets [10,11]. the increase in fentanylrelated overdose deaths are thought to be driven by illicit fentanyl and its analogs [11]. carfentanil, which is a fentanyl analog is used as a tranquilizer for elephants and not meant for human use [12], and it is estimated to be 10,000 times more potent than morphine and often sold mixed with heroin, cocaine or counterfeit pills [11]. 2 method pubmed and internet searches were performed to find information on the u.s. opioid epidemic. in addition, searches were performed to retrieve information about pdmps and state-specific mandates along with presentation slides and learnings from the 2018 national rx drug abuse & heroin summit in atlanta, ga. 3 results 3.1 background on the u.s. opioid epidemic figure 1 [13] shows the three waves attributed to the rise in opioid overdose deaths. the 1990s mark the first wave with increase in opioid prescriptions with notable increase in opioid overdose deaths around 1999 [2]. there was an increased awareness and focus on treatment of chronic pain around this time, and an institute of medicine report attributed the increase in prevalence of chronic pain during the 1990s to “greater patient expectations for pain relief, musculoskeletal disorders of an aging population, obesity, increased survivorship after injury and cancer, and increasing frequency and complexity of surgery. [14]” pharmaceutical companies continued to proliferate in manufacturing opioids including sublingual, transdermal, extended-release and nasal spray formulation products, and some pharmaceutical manufacturers marketed opioids by minimizing addiction potential and promoting off-label uses of opioid indicated for acute breakthrough pain in cancer patients [14]. the second wave began around 2010, and it is characterized by a significant rise in heroin-related overdose deaths [2,14]. between 2010 and 2015, heroin overdose deaths tripled [14]. the last wave which began in 2013 and continues today is characterized by a pronounced increase in synthetic opioid-related overdose deaths, predominantly related to the rise in illicit fentanyl [2]. overdose deaths related to fentanyl analogs increased by 540% between 2013 and 2016 [14]. u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi figure 1: overdose death rates involving opioids, by type, united states, 2000-2017 source: cdc [13] 3.2 impact on public health cdc announced that u.s. life expectancy declined in 2017 for the third year in a row, driven by drug overdose deaths and suicides [15]. the average life expectancy decreased from 78.9 in 2014 to 78.6 in 2017, and it is the longest sustained life expectancy decline since 1915 through 1918 during world war 1 and a flu pandemic that killed estimated 50 million worldwide [15,16]. there has been a 19% increase of overdose deaths among teenagers from 2014 to 2015, and blood-born infection transmission from drug injection equipment sharing continues to be a problem [17]. according to cdc, estimated one in 23 women and one in 36 men using drugs via injections will have hiv diagnosis in their lifetime, and opioid use is thought to have contributed to hepatitis c infection transmission which is estimated to have tripled between 2000 and 2015 [17]. furthermore, infants exposed to opioids in utero are at a risk of neonatal abstinence syndrome (nas), and prenatal exposure to opioids have been associated with poor fetal growth, preterm birth or still birth [18]. the incidence of nas is reported to have increased 433% between 2004 and 2014, and this translates to increase from 1.5 per 1,000 hospital births to 8.0 per 1,000 hospital births [18]. feder, letourneau & brook [19] address at least five ways the opioid epidemic may affect and harm health and safety of children and adolescents: intentional or accidental ingestion of prescription drugs, misuse of opioids in pregnancy resulting in problems such as nas, inadequate prenatal care and low birth weight, impaired parenting and attachment due to parental opioid misuse, material deprivation due to family finances being spent on drugs, and extended separation such as foster care due to parent’s incarceration, drug treatment or death. the opioid epidemic has a complex impact on public health intertwined with variable factors such as mental health and social determinants of health. studies suggest links between childhood trauma and substance use u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi disorder [20]. a study of urban primary care patient sample by khoury, tang, bradley, cubells, & ressler [20] concluded “data show strong links between childhood traumatization and suds, and their joint associations with ptsd outcome.” studies also suggest there is a history of major depressive disorder in greater than 50% of patients with opioid use disorder, and opioid use disorder was associated with risk of suicidal ideation and suicide [21]. dasgupta, beletsky & ciccarone [14] “posit that the crisis is fundamentally fueled by economic and social upheaval, its etiology closely linked to the role of opioids as a refuge from physical and psychological trauma, concentrated disadvantage, isolation, and hopelessness. overreliance on opioid medications is emblematic of a health care system that incentivizes quick, simplistic answers to complex physical and mental health needs.” the authors state the increase in opioid prescription is not solely to blame for the current opioid epidemic, but various structural factors contributed to it [14]. for example, individuals may somaticize social disasters and economic hardships into physical pain, and childhood trauma is associated with increased opioid use in later years [14]. the counties with highest overdose rates have lowest levels of social capital, and individuals living in low socioeconomic areas have increased likelihood of developing chronic pain after automobile accidents which is mediated by stress response genes [14]. the authors concluded there is an urgency to integrate clinical care and addressing individuals’ structural environments [14]. park, lin, hosanagar, kogowski, paige & bohnert [22] state “opioid dosage was the factor most consistently analyzed and also associated with increased risk of overdose. other risk factors include concurrent use of sedative hypnotics, use of extended-release/longacting opioids, and the presence of substance use and other mental health disorder comorbidities.” the opioid epidemic also has a significant impact on the safety of first responders when they come into contact with highly potent and fast-acting fentanyl and fentanyl analogs during their routine emergency responses [23]. thirty-three pounds of fentanyl seized in boston is estimated to be enough to wipe out the entire state of massachusetts [23]. first responders must be trained to recognize signs of exposure such as disorientation, respiratory distress, coughing, sedation, and cardiac arrest; they also need to receive adequate training, wear gloves, masks, eye protection and be prepared to administer opioid overdose reversal drug naloxone when necessary [23]. cdc estimates the annual “economic burden” of prescription misuse in the u.s. including healthcare cost, productivity loss, addiction treatment and cost of criminal justice is $78.5 billion [24]. the public broadcasting service [25] news hour segment titled “how the opioid crisis decimated the american workforce” explored through interviews, the devastating impact of opioid crisis on the northeastern ohio families and workforce. the segment revealed that employers are having difficulty finding skilled employees that can pass drug tests, and alan krueger from princeton university stated in the interview, “for both prime-age men and prime-age women, the increase in prescriptions over the last 15 years can account for perhaps 20 percent of the drop in labor force participation that we have seen [25].” according to burke, goplerud & hartley [26], entertainment, recreation, food and construction industry have higher than average relative prevalence of substance use disorder; costs of missed work per employee range from $187 to $3,941 annually depending on the industry sector [26]. additionally, the job turnover rate is 36% vs. 25% in general workforce when employees have u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi untreated or active substance use disorder (sud) with annual per capita cost from $512 to greater than $4,000 [26]. in 2014, the cost of healthcare for an employee with sud was $2,198, and cost of healthcare for an employee with pain medication use disorder was approximately double at $5,586, primarily driven by emergency department use [26]. employers’ investment in treatment and workers in recovery for one year show improvement and return to baseline [26]. 3.3 prevention, treatment, reversal of opioid overdose the centers for disease control and prevention (cdc) promotes the following approach in opioid overdose prevention [27]: • improve opioid prescribing: in 2016, cdc published the “cdc guidelines for prescribing opioids for chronic pain” which covers three conceptual areas: when to initiate or continue opioid therapy for treatment of chronic pain, selection of opioid, dosage, duration, follow-up and discontinuation of opioid therapy, and assessment of risk and addressing harm from opioid use [28,29]. this guideline aims to reduce the gap in opioid prescribing training for primary care providers and address safer and more effective treatment of chronic pain outside of active cancer treatment, palliative and end-of-life care [29]. • prevent opioid use disorder: promote various ways to help reduce opioid exposure and opioid use disorder (oud) including the use of prescription drug monitoring program (pdmp), patient education on safe storage and disposal of prescription opioid medications, and prescription insurance prior authorization/quantity limit strategies [30]. additionally, funding of “prevention for states” program for 29 states provides resources and support for interventions to prevent prescription drug overdoses, and cdc’s rxawareness campaign shares resources to educate patients and families about the risk of prescription opioids and the impact and cost of overdose [30]. • treat opioid use disorder: expand access to evidence-based treatments such as medication-assisted treatment (mat) in addition to behavioral therapy and counseling [31]. substance abuse and mental health services administration (samhsa) makes “behavioral health treatment services locator” available for patients to confidentially and anonymously find treatment facilities [32]. • reverse overdose to prevent death: expand access to life-saving opioid overdose reversal medication naloxone through training of and use by law enforcement officials and emergency medical staff, local organizations, and standing orders for dispending at the pharmacies [33]. in addition, the u.s. department of health and human services (hhs) announced its 5-point strategy in response to the u.s. opioid epidemic [34]: • better prevention, treatment and recovery services: grants in support of access to treatment, prevention, recovery and facilitate treatment coverage through state medicaid programs [35]. u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi • better data: support of more timely and accelerated data and reporting including cdc drug overdose data and the centers for medicare and medicaid services (cms) medicare opioid prescription mapping tool [36]. • better pain management: promote evidence-based pain management methods including identification and recommendation proposals to address gaps/inconsistencies and establishing healthy people 2020 objectives [37]. • better availability of overdose-reversing drugs: improve access to overdosereversing naloxone drugs to individuals such as those receiving prescription opioid pain medications, illicit drugs such as heroin or fentanyl, and family and friends of individuals with opioid use disorder [38]. • better research: support pain and addiction research to ensure evidence-based policies, inform clinical practitioners and reduce prescription opioid use [39]. in addition to the approaches and strategies outlined by cdc and hhs, there is an increased emphasis on harm reduction such as syringe service programs to prevent transmission of hepatitis c infection and human immunodeficiency virus infections [4]. furthermore, education and access to treatment need to be expanded to address and prevent a baby being born with nas every 15 minutes [40]. public health and law enforcement agencies, medical examiners and coroners working collaboratively can improve detection of drug overdose outbreaks related to illicit opioids allowing for expedited response and targeted intervention [4]. 3.4 data, surveillance & technology-driven initiatives there are various data, surveillance and technology-driven initiatives in response to the opioid epidemic. the initiatives aim to research and develop targeted interventions, strengthen access to opioid use disorder treatment, and develop strategies and tools for “faster data” to track and response to opioid overdoses. examples are cdc-funded enhanced state opioid overdose surveillance program (esoos) and the use of telemedicine technology for substance use disorder/behavioral health treatments [41]. 3.4.1 cdc-funded enhanced state opioid overdose surveillance program (esoos) the esoos program funded 12 states in september 2016 with 20 states and district of columbia added in september 2017 [41]. the first strategy for esoos is syndromic surveillance using emergency department data for timely non-fatal opioid overdose reporting, and this is achieved by detecting sharp increases or decreases [41]. the second strategy is reporting on fatal opioid overdose through state unintentional drug overdose reporting system (sudors) that captures detailed death scene investigation and toxicology information; other risk factors related to the fatal overdoses are also captured [41]. this strategy can detect and inform newly emerging substances, common drug combinations, and helps identify risk factors and circumstances that may be associated with fatal overdoses [41]. lastly, the third strategy is widespread dissemination of findings to key stakeholders to improve local and state public health prevention and response efforts, and trends are tracked to inform national policy [41]. u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi singleton, saavedra & broad [42] presented “states with fast data: lessons learned from kentucky, new mexico and wisconsin” at the 2018 national rx drug abuse & heroin summit. kentucky, new mexico and wisconsin are three of the states receiving the esoos grant [42]. kentucky made efforts to improve drug overdose surveillance reporting including better drug specificity on death certificates, and while the process is slow, kentucky is making progress in reducing lag time between death events and reporting [42]. this is done by making improvements to drug overdose fatality surveillance system (dofss) such as adding a full-time abstractor to decrease case initiation to completion time, automation of toxicology reporting, database platform change and emergency medication services integration [42]. for example, the mean time from death to case initiation decreased from 15 months in 2014 to 4 months in 2017, and the mean time from receiving coroner report to entry in dofss decreased from 87 days in 2016 to 27 days in 2017 [42]. emergency departments (ed) voluntarily participate in syndromic surveillance of nonfatal overdoses, and providers who elect to participate in kentucky’s ed sys forward messages to ky health information exchange (khie) where messages are de-identified and batches transmitted to cdc biosense platform [42]. median days between admit to first message, chief complaint, diagnosis in electronic surveillance system for the early notification of communitybased epidemics (essence) decreased from days to hours between may 2016 to march 2018 [42]. the emergency department data has its challenges; participation is voluntary with the primary incentive being meaningful use and dropped feeds and system lags are not resolved quickly [42]. the new mexico department of health learned through the esoos program that buy-in of emergency medical system (ems) data managers, providing feedback to emergency medical technicians (emt), and discussion with other states utilizing ems data for surveillance is vital in establishing standard definitions for suspected overdose cases and reducing missing information from the field [42]. new mexico also faced challenges due to lack of uniformity in ed data and found communicating to the ed staff about how the data collected is used can help bridge the gap [42]. in wisconsin, the wisconsin ambulance run data systems (wards) which has been in use since 2010 captures 90% of ems data [42]. while the data submission is mandatory within seven days of incident, it is challenging to work with the data due to decentralization and free text data entry [42]. the ambulance data is linked with multiple data systems for hospital discharge and death certificate information, and the future goal is integration of pdmp and national violent death reporting system (nvdrs) [42]. additionally, while 84% of hospital ed submit syndromic surveillance data through biosense platform funded through meaningful use, the large volume of data reduces system performance, and historic data upload and data quality validation is crucial and a challenge [42]. despite the challenges, local health departments were educated on using the syndromic data, and a pilot alert system was developed [42]. wisconsin department of public health also worked through challenges related to decentralization of toxicology testing and data collection from corners and medical examiners, and as of the presentation in april 2018, death investigation reports were available for 95% of opioid fatalities [42]. u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 3.4.2 telehealth it is estimated that less than 20% of individuals who need treatment for substance use disorder receive it, and access to behavioral health care and opioid use disorder treatment is particularly challenging in rural areas and correctional facilities [43]. telehealth may bridge the gap in underresourced areas by delivering virtual behavioral health and education services most frequently using live video but also using emails, text messages and telephony; it can also support rural clinicians in need of specialty consultation [43]. according to yellowlees [44], virtual care may have advantages for the patient given s/he can build relationships with providers outside of the residing community and may provider better environment to discuss awkward, embarrassing or stigmatizing topics. additionally, transcription and translation services can be integrated [44]. in a 2 year-retrospective data analysis study of individuals diagnosed with opioid use disorder by zheng, et al. [45], there was no significant statistical difference in additional substance use, average time to 30 and 90 days of abstinence and treatment retention rates between telepsychiatry buprenorphine mat interventions compared with face-to-face mat treatments. 4 discussion 4.1 prescription opioid utilization in the u.s. & changing opioid prescribing practices the washington post published an article on march 15, 2017 written by humphreys [46] titled “americans use far more opioids than anyone else in the world.” in this article, humphreys notes that according to the united nations data of top 25 opioid consuming countries in the world, the united states is the heaviest consumer of opioids in the world [46]. according to the u.n. report, 99% of world’s supply of hydrocodone is consumed by americans; this disparity of heavy opioid consumption does not appear to be related to the aging population, because other countries such as australia and italy have higher proportion of population 65 years and older [46]. in another washington post article, humphreys [47] explores if the high consumption of opioids in the u.s. is due to unusually high levels of pain. according to a 2008 research, the age standardized prevalence of chronic pain in the u.s. was similar to italy and france; however, the opioid consumption per capita was approximately 6 to 8 times higher in the u.s. compared to italy and france [47]. humphreys [46,47] points out in both articles that a notable difference in the u.s. compared to other countries is the lack of constraints placed on the pharmaceutical manufacturers to market and promote their products to patients and prescribers, as well as to lobby and donate to political causes and regulatory bodies. in the 2017 report of office of inspector general (oig), opioid prescription records from 2016 were analyzed as part of a strategy to protect medicare part d beneficiaries from prescription drug abuse and harm [48]. the analysis found that in 2016, one in three medicare part d recipients received at least one prescription opioid, and approximately 500,000 beneficiaries received high doses of opioid defined as greater than 120mg morphine equivalent dose (med) per day for at least 3 months [48]. additionally, approximately 400 prescribers had prescribing habits considered outside the norm warranting further scrutiny [48]. furthermore, the study found that approximately 70,000 beneficiaries were at serious risk by receiving very high doses of opioid [48]. approximately 22,000 beneficiaries appeared to be doctor shopping based on the number of u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi prescribers and pharmacies used to obtain these medications and indicated potential drug seeking behavior for nonmedical use or diversion; they may also be instances of stolen beneficiary number or that the beneficiary’s care is not closely monitored or coordinated by the providers [48]. the overall opioid prescribing rate in the u.s. declined from 2012 to 2017 as illustrated in figure 2 [49]. in 2017, the rate declined to the lowest in more than 10 years; however, opioid prescribing rate is still at 58.7 prescriptions per 100 persons totaling more than 191 million prescription in 2017 [49]. furthermore, prescribing rates remain high in certain areas of the country. according to cdc, 16% of counties dispensed enough opioid prescriptions for every person with some counties at rates seven times higher than the overall national rate [50]. figure 2: trends in annual opioid prescribing rates by overall and high-dose prescriptions source: cdc [49] nelson, juurlink, & perrone [51] stated “the chronic, relapsing nature of opioid addiction means most patients are never ‘cured,’ and the best outcome is long-term recovery. the lifelong implications of this disease far outweigh the limited benefits of opioids in the treatment of chronic pain, and in many cases the risks inherent in the treatment of acute pain with opioids. the encouraging finding of declining opioid initiation rates should be tempered by the increasing rates of nonmedical opioid use disorders and the limited utilization of treatment programs. although multifaceted approaches are needed to successfully address the opioid epidemic, an important step is to start at the beginning and keep opioid-naive patients opioid naive.” 4.2 prescription drug monitoring program (pdmp) prescription drug monitoring programs (pdmps), also referred to as pmps are state-level electronic databases used to track controlled substance prescription data [52]. pdmps are tools for u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi providers to make informed prescribing and dispensing decisions based on the patient’s utilization, and pdmps have the potential to help improve patient safety and public health [52]. despite the mixed findings, pdmp evaluations demonstrated prescribing behavior changes, reduction in utilization of multiple providers, and decrease in substance abuse treatment admissions [52]. the benefit of pdmp is only realized when the provider actively utilizes the information in the pdmp. each state implements pdmp in ways it sees fit; some states mandate the use of pdmps in established circumstances such as prior to prescribing or dispensing controlled substances [52]. in addition, while pharmacists enter prescription data into the state’s pdmp, the data submission intervals may range from minutes, days, weeks or month [52]. data collected may also be used by state health departments, state insurance programs, healthcare licensure boards and law enforcement agencies as shown in figure 3 below [52]. figure 3: prescription drug monitoring program (pdmp) source: cdc [52] when opioid medications are prescribed, there needs to be a mutual understanding between the provider and the patient that long term use of opioids can result in physiological dependence, particularly when opioid are prescribed for non-cancer diagnoses [53]. in addition to pain agreement to ensure mutual understanding and expectation of risks, benefit and responsible medication use, pdmp is a tool providers can use to make informed prescribing decisions [53]. for example, pdmp can provide information to confirm lost prescriptions are in fact lost and not being diverted [53]. in addition, pdmp can inform the prescriber about the patient’s controlled substance utilization including those from other prescribers filled at multiple pharmacies and resolve concerns regarding early fills by checking the previous fill dates submitted by the pharmacy [53]. the following is an example of an institutional protocol implementation including a pdmp consult. according to kolodny [54], dentistry accounted for 28.9% of opioid prescriptions. u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi additionally, more opioids are prescribed for teenagers by dentists compared with all other specialties [55]. furthermore, miech, johnston, o’malley, keyes & heard [56] concluded that the “use of prescribed opioids before the 12th grade is independently associated with future opioid misuse among patients with little drug experience and who disapprove of illegal drug use.” given these concerns, the university of minnesota, school of dentistry has established a protocol for teaching and clinical practice to use non-opioid analgesics as first-line agent and use opioid at the lowest effective dose when required [54]. as part of the protocol, clinicians must consult the pdmp prior to issuing an opioid prescription, and reasons for deviation from the protocol are documented [54]. 4.2.1 prescription drug monitoring program (pdmp) mandates by state as previously mentioned, pdmps are state-level electronic databases implemented and regulated by each state [52]. as of 2018, 41 states mandate providers to use the pdmp; however, the mandated circumstances vary including drugs it tracks, frequency, and exemption parameters [57]. for example, arizona statute a.r.s. § 36-2606 mandates medical practitioners who possess dea license to review patient’s record in the pdmp for preceding 12 months prior to prescribing schedule ii controlled substances or a benzodiazepine [58]. additionally, effective april 26, 2018, dispensing pharmacists working in an outpatient setting and whose employer has a u.s. dea registration must review patient records in the pdmp for preceding 12-month prior to dispensing schedule ii controlled substances [58]. the state of michigan recognizes gabapentin as schedule v controlled substance and requires gabapentin prescription data submission to its pdmp, michigan automated prescription system effective january 4, 2019 [59]. according to pew [57], comprehensive mandates that apply to all prescribers and to all initial opioid prescriptions at minimum are associated with reduction in utilization of multiple prescribers, pharmacies and number of opioid prescriptions. a study by rasubala, pernapati, velasquez, burk, & ren [60] found that since the mandate to consult pdmp prior to opioid prescribing in new york state, there has been a 78% reduction in absolute quantity of opioids prescribed by dentists over 3 months from 5096 pills to 1120. paulozzi, kilbourne, desai [61] concluded pdmps appear to have minimal effect on the overall opioid consumption and overdose mortality rate, and improvement in the use of pdmp data to positively impact overdose rate is necessary. patrick, fry, jones & buntin [62] determined that states with prescription drug monitoring programs reduced opioid-related overdose deaths by 1.12 per 100,000 population and the states with more robust program characteristics such as tracking larger number of drugs of abuse potential and updating the pdmp data at least weekly had a higher reduction in mortality. 4.2.2 prescription drug monitoring program (pdmp) challenges, integration, interoperability and improvement efforts while pdmps can be useful tools for providers, the limited data sharing across states limit their usefulness particularly for providers working near state borders. in addition, lack of pdmp data integration with health information systems such as health information exchange (hie), electronic health record (ehr) and pharmacy dispensing software (pds) systems present workflow challenges and barriers [63]. some specific deterrents for providers include the need for clinicians u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi to log in for pdmp search, time it takes for the search to return the records requested, and limited understanding on using data that is returned from the search [64]. the substance abuse and mental health services administration (samhsa) funded the pdmp electronic health records integration and interoperability expansion (pehriie) program in nine states during fiscal years 2012 to 2016 [63]. this effort aimed to address pdmp data integration challenges, better inform clinical decisions through interstate data sharing and promote point of care interventions thus improvement in outcomes [63,64]. figure 4 depicts general ehr, pharmacy and pdmp integration established in the pehriie program [63]. figure 4. ehr, pharmacy, and pdmp integration source: cdc [63] five of eight states were able to integrate pmdp reports with pds systems (local or statewide), hies or ehrs [63]. three states, kansas, washington and illinois had data to examine possible impact of the program; kansas completed integration of pdmp with the via christi health network [63]. solicited reports by via christi health network providers increased greater than sevenfold from 31,156 in 2013 to 223,000 in 2015 [63]. as a comparison, statewide pdmp reports solicited excluding via christi prescribers increased 183% during the same time period from 23,171 in 2013 to 65,242 in 2015 [63]. the state of washington completed pdmp integration with its hie, one health port and the emergency department information exchange (edie) late 2014 [63]. during the 2014 calendar year, 26,546 reports were provided via edie; it increased 80fold in 2015 calendar year to 2,222,446 [63]. lastly, data from illinois’ pdmp integration with ehrs at anderson hospital suggest that increase in pdmp report resulting from the integration u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi was associated with decreased opioid prescribing [63]. it is worth noting there was a 145-fold increase in reports solicited by registered prescribers at the anderson hospital, from 6.9 reports per provider in 2013 to 998.2 per provider in 2015 [63]. in comparison, statewide number during the same period was 7.26 per provider in 2013 to 9.27 in 2015 [63]. furthermore, there was a 22% reduction in number of opioid prescriptions provided by anderson hospital provider compared with a 13% increase statewide during the same period [63]. there was also a 41% reduction in patients receiving at least one opioid prescription from anderson hospital providers compared with a 1% statewide increase [63]. in addition to the pdmp report integration with ehrs, pds and hies, six of nine states were able to initiate interstate data sharing [63]. illinois, kansas and west virginia achieved two-way interstate data exchange with three-quarters of their border states; the interstate data exchange expanded to include average of 90% of their border states for indiana and ohio [63]. there was a notable number of pdmp requests by in-state providers for out-of-state data [63]. various other states are also making efforts to improve their pdmps with goal of making the data content more meaningful to providers, easier to use and affect prescribing and utilization. according to mcdonald [65], state of rhode island implemented pdmp “dispenser threshold alerts” in 2017 that include alerts on use of more than 3 prescribers and pharmacies in the previous 6 months, morphine milligram equivalent greater than 90mg per day, overlapping opioid and benzodiazepine prescriptions and continuous days of opioid. these clinical alerts are important in knowledge, risk and time management, public health interest and connects clinical alerts to existing regulations such as the food and drug administration’s black box warning regarding the risk of concurrent administration of opioid and a benzodiazepine [65,66]. there has been a gradual decrease in total number of clinical alerts from may 2017 through january 2018, and the rhode island department of health will continue to evaluate how the clinical alerts affect pdmp targeted medication utilization, prescribing and ease of use for providers [65]. the state of new mexico like many other states utilizes the pdmp data to generate prescriber reports. the “new mexico prescription monitoring program prescriber feedback report” compares a particular provider’s 6 month controlled substance prescribing data to the average of other prescribers in the same specialty [42]. this report is generated in partnership with the state board of pharmacy and sent to prescribers who have 20 or more controlled substance patients in the review period [42]. the state of new mexico cited pdmp challenges including individual patient identification, linking the pdmp report request and patients, linking prescribers who may have multiple dea numbers and noted the importance of data validation [42]. carolinas healthcare system is a health system that consists of over 40 hospitals, over 900 care locations, over 15,000 clinicians and greater than 10 million annual encounters [67]. in order to address the prescription opioid abuse and overdoses, clinical decision support, prescription reporting with immediate medication utilization mapping (primum) was implemented within the electronic medical record (emr) and tested to determine how it affects prescribing behaviors [67,68]. upon selection of a controlled substance, the emr searches patient’s chart for risk factors defined within the system; if a risk factor is identified, the emr provides an alert and gives the provider an option to continue to prescribe or discontinue the prescription [67]. the emr also has a direct hyperlink to the north carolina and south carolina pdmp [67]. risk factor triggers such u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi as early refills, previous history of opiate or benzodiazepine overdose, and a positive screening for cocaine and marijuana were selected based on literature review [67]. this study determined that the alerts had moderate effect resulting in 13-25% of prescriptions cancelled and the effect on the behavior varied by specialty [67]. the carolinas healthcare system has plans to further analyze the data and collaborate with the north carolina and south carolina pdmps for integration [67]. 5 limitations due to the substantial number of literatures available on the subject of opioid epidemic and pdmps, only a small sample was selected for review and does not represent complete spectrum of available views and findings. in addition, due to the variability in pdmp mandates by state, only a small sample was selected as examples. 6 conclusion the world health organization (who) defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity [69].” recent tragic death of the legendary musician prince at the age of 57 brought to light the indiscriminate effect of opioid addiction and overdose deaths; it was determined that prince died of fentanyl overdose, taking what he thought was vicodin but actually laced with fentanyl [70]. it is clear that the u.s. opioid epidemic has a tremendous impact on public health that not only affects the adults in this country but also the next generation. given the statistics and studies that suggest many of the illicit opioid users start with prescription opioids, continued advancement in the area of pdmp integration and interoperability is necessary. pdmps are valuable tools for providers in making informed prescribing decisions. however, variability in state mandates and varying degrees of integration and interoperability across states may limit their usefulness as decision support tools. for example, a provider in a state that requires pharmacies to submit the controlled substance dispensing information within 24 hours may not see the prescriptions filled on the same day from other prescribers at different pharmacies on the pdmp report. moreover, the prescriber may need to log in each time to obtain a pdmp report which may disrupt his/her workflow and become a deterrent for consistent use. for pdmps to be meaningful clinical decision support tool for prescribing decisions and data source for public health departments to inform targeted interventions, complete and consistent real time data is necessary. furthermore, they need to be simple, efficient and integrated into the healthcare providers’ workflow, interoperable with other systems such as ehrs, emrs, and hie and scalable. the pdmp integrated clinical decision support systems need to supply to healthcare providers access to complete, timely and evidence-based information that can meaningfully inform prescribing decisions and communication with patients that affect measurable outcomes. sharing best practices, challenges and lessons learned among states and organizations may inform strategic and systematic use of pdmps to improve public health outcomes. as with other system development or enhancement efforts, stakeholder engagement, particularly end-user engagement and participation are crucial; privacy, security, and hipaa considerations must also be a priority. u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 7 references 1. u.s. department of health & human services [internet]. washington, d.c.: hhs; 2017 oct 26 [cited 2019 apr 5]. hhs acting secretary declares public health emergency to address national opioid crisis; [about 1 screen]. available from: https://www.hhs.gov/about/news/2017/10/26/hhs-acting-secretary-declares-public-healthemergency-address-national-opioid-crisis.html 2. centers for disease control and prevention [internet]. atlanta: the center; 2018 dec 19 [cited 2019 apr 5]. opioid overdose: understanding the epidemic; [about 2 screens]. available from: https://www.cdc.gov/drugoverdose/epidemic/index.html 3. centers for disease control and prevention [internet]. atlanta: cdc; 2018 dec 19 [cited 2019 apr 5]. opioid overdose: prescription opioid data; [about 5 screens]. available from: https://www.cdc.gov/drugoverdose/data/prescribing.html 4. rudd ra, aleshire n, zibbell je, gladden rm. increases in drug and opioid overdose deaths united states, 2000-2014. morb mortal wkly rep [internet]. 2016 jan [cited 2019 apr 4];64(50): [about 1 p.] available from https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6450a3.htm?s_cid=mm6450a3_w 5. vivolo-kantor am, seth p, gladden rm, mattson cl, baldwin gt, et al. 2018. vital signs: trends in emergency department visits for suspected opioid overdoses united states, july 2016-september 2017. mmwr morb mortal wkly rep. 67(9), 279-85. doi:. pubmed https://doi.org/10.15585/mmwr.mm6709e1 6. national institute on drug abuse [internet]. bethesda: nida; 2018 jun [cited 2019 apr 5]. prescription opioids; [about 1 screen]. available from: https://www.drugabuse.gov/publications/drugfacts/prescription-opioids 7. centers for disease control and prevention [internet]. atlanta: cdc; 2017 aug 29 [cited 2019 apr 5] opioid overdose: prescription opioids; [about 4 screens]. available from: https://www.cdc.gov/drugoverdose/opioids/prescribed.html 8. centers for disease control and prevention [internet]. atlanta: cdc; 2018 dec 19 [cited 2019 apr 5]. opioid overdose: heroin overdose data; [about 4 screens]. available from: https://www.cdc.gov/drugoverdose/data/heroin.html 9. centers for disease control and prevention [internet]. atlanta: cdc; 2018 dec 19 [cited 2019 apr 5]. opioid overdose: heroin; [about 4 screens]. available from: https://www.cdc.gov/drugoverdose/opioids/heroin.html 10. centers for disease control and prevention [internet]. atlanta: cdc; 2018 dec 19 [cited 2019 apr 5]. opioid overdose: fentanyl; [about 3 screens]. available from: https://www.cdc.gov/drugoverdose/opioids/fentanyl.html https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29518069&dopt=abstract https://doi.org/10.15585/mmwr.mm6709e1 u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 11. centers for disease control and prevention [internet]. atlanta: cdc; 2018 dec 19 [cited 2019 apr 5]. opioid overdose: fentanyl overdose data; [about 4 screens]. available from: https://www.cdc.gov/drugoverdose/data/fentanyl.html 12. american addiction centers [internet]. san diego: drugabuse.com; c2019 [cited 2019 apr 5]. let’s talk about the elephant tranquilizer in the room; [about 1 screen]. available from: https://drugabuse.com/lets-talk-about-the-elephant-tranquilizer-in-the-room/ 13. centers for disease control and prevention [internet]. atlanta: cdc; 2018 dec 19 [cited 2019 apr 5]. opioid overdose: opioid data analysis and resources; [about 1 screens]. available from: https://www.cdc.gov/drugoverdose/data/analysis.html 14. dasgupta n, beletsky l, ciccarone d. 2018. opioid crisis: no easy fix to its social and economic determinants. am j public health. 108(2), 182-86. epub feb. 2018. doi:. pubmed https://doi.org/10.2105/ajph.2017.304187 15. harvard th. chan school of public health [internet]. boston: the school; c2019 [cited 2019 apr 5]. u.s. life expectancy drops again; [about 1 screen]. available from: https://www.hsph.harvard.edu/news/hsph-in-the-news/u-s-life-expectancy-drops-again/ 16. bernstein lus. life expectancy declines again, a dismal trend not seen since world war i. the washington post [internet]. 2018 nov 29 [cited 2019 apr 5]. available from: https://www.washingtonpost.com/national/health-science/us-life-expectancy-declines-againa-dismal-trend-not-seen-since-world-war-i/2018/11/28/ae58bc8c-f28c-11e8-bc7968604ed88993_story.html?noredirect=on&utm_term=.012ce23f4c6a 17. gostin lo, hodge jg, noe sa. 2017. reframing the opioid epidemic as a national emergency. jama. 318(16), 1539-40. doi:. pubmed https://doi.org/10.1001/jama.2017.13358 18. jilani sm, frey mt, pepin d, jewell t, jordan m, et al. 2019. evaluation of state-mandated reporting of neonatal abstinence syndrome six states, 2013-2017. mmwr morb mortal wkly rep. 68(1), 6-10. doi:. pubmed https://doi.org/10.15585/mmwr.mm6801a2 19. feder ka, letourneau ej, brook j. children in the opioid epidemic: addressing the next generation’s public health crisis. pediatrics [internet]. 2019 jan [cited 2019 apr 4];143(1): [about 1 p.]. available from: https://pediatrics.aappublications.org/content/143/1/e20181656 20. khoury l, tang yl, bradley b, cubells jf, ressler kj. 2010. substance use, childhood traumatic experience, and posttraumatic stress disorder in an urban civilian population. depress anxiety. 27(12), 1077-86. doi:. pubmed https://doi.org/10.1002/da.20751 21. srivastava ab, gold ms. missed opportunities: opioid overdoses and suicide. clinical psychiatry news [internet]. 2017 aug 29 [cited apr 6] available from: https://www.mdedge.com/psychiatry/article/145653/addiction-medicine/missedopportunities-opioid-overdoses-and-suicide https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29267060&dopt=abstract https://doi.org/10.2105/ajph.2017.304187 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28832871&dopt=abstract https://doi.org/10.1001/jama.2017.13358 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30629576&dopt=abstract https://doi.org/10.15585/mmwr.mm6801a2 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21049532&dopt=abstract https://doi.org/10.1002/da.20751 u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 22. park tw, lin la, hosanagar a, kogowski a, paige k, et al. 2016. understanding risk factors for opioid overdose in clinical populations to inform treatment and policy. j addict med. 10(6), 369-81. pubmed https://doi.org/10.1097/adm.0000000000000245 23. international association of fire fighters (iaff). ems response to opioid overdose and fire fighter health center of excellence. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/124621-5ac4183472305.pdf 24. national institute on drug abuse [internet]. bethesda: nida; 2019 jan [cited 2019 apr 6]. prescription opioids; [about 1 screen]. available from: https://www.drugabuse.gov/drugsabuse/opioids/opioid-overdose-crisis 25. public broadcasting service. how the opioid crisis decimated the american workforce. pbs news hour [internet]. 2017 oct 5 [cited 2019 apr 6]. available from: https://www.pbs.org/newshour/show/opioid-crisis-decimated-american-workforce#transcript 26. burke j, goplerud e, hartley s. real costs of rx pain meds, opioids and substance use in the workplace: what employers and communities can do. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/123755-5ac0f531c5d31.pdf 27. centers for disease control and prevention [internet]. atlanta: cdc; 2017 aug 31 [cited 2019 apr 6]. overdose prevention: opioid overdose; [about 1 screen]. available from: https://www.cdc.gov/drugoverdose/prevention/index.html 28. centers for disease control and prevention [internet]. atlanta: cdc; 2019 apr 17 [cited 2019 may 6]. opioid overdose: cdc guideline for prescribing opioids for chronic pain; [about 4 screens]. retrieved from https://www.cdc.gov/drugoverdose/prescribing/guideline.html 29. dowell d, haegerich tm, chou r. 2016. cdc guideline for prescribing opioids for chronic pain--united states, 2016. jama. 315(15), 1624-45. doi:. pubmed https://doi.org/10.1001/jama.2016.1464 30. centers for disease control and prevention [internet]. atlanta: cdc; 2017 oct 11 [cited 2019 apr 6]. overdose prevention: prevent opioid use disorder; [about 2 screens]. available from: https://www.cdc.gov/drugoverdose/prevention/opioid-use-disorder.html 31. centers for disease control and prevention [internet]. atlanta: cdc; 2017 aug 23 [cited 2019 apr 6]. opioid overdose. treat opioid use disorder; [about 4 screens]. available from: https://www.cdc.gov/drugoverdose/prevention/treatment.html 32. substance abuse and mental health services administration. [internet]. rockville: samhsa; 2019 [cited 2019 apr 6]. behavioral health treatment services locator; [about 1 screen]. available from: https://findtreatment.samhsa.gov/ https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27525471&dopt=abstract https://doi.org/10.1097/adm.0000000000000245 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26977696&dopt=abstract https://doi.org/10.1001/jama.2016.1464 u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 33. centers for disease control and prevention [internet]. atlanta: cdc; 2017 aug 29 [cited 2019 apr 6]. opioid overdose: reverse overdose to prevent death; [about 1 screen] available from: https://www.cdc.gov/drugoverdose/prevention/reverse-od.html 34. u.s. department of health & human services [internet]. washington, d.c.: hhs.gov/opioids; 2018 aug 7 [cited 2019 apr 6]. 5-point strategy to combat the opioid crisis; [about 1 screen]. available from: https://www.hhs.gov/opioids/about-theepidemic/hhs-response/index.html 35. u.s. department of health & human services [internet]. washington, d.c.: hhs.gov/opioids; 2018 may 15 [cited 2019 apr 6]. better prevention, treatment & recovery services; [about 1 screen]. available from: https://www.hhs.gov/opioids/about-theepidemic/hhs-response/better-access/index.html 36. u.s. department of health & human services [internet]. washington, d.c.: hhs.gov/opioids; 2018 may 15 [cited 2019 apr 6]. better data; [about 1 screen]. available from: https://www.hhs.gov/opioids/about-the-epidemic/hhs-response/betterdata/index.html 37. u.s. department of health & human services [internet]. washington, d.c.: hhs.gov/opioids; 2018 may 15 [cited 2019 apr 6]. better pain management; [about 1 screen]. available from: https://www.hhs.gov/opioids/about-the-epidemic/hhsresponse/better-pain-management/index.html 38. u.s. department of health & human services [internet]. washington, d.c.: hhs.gov/opioids; 2018 may 15 [cited 2019 apr 6]. better availability of overdosereversing drugs; [about 1 screen]. available from: https://www.hhs.gov/opioids/about-theepidemic/hhs-response/better-overdose-response/index.html 39. u.s. department of health & human services [internet]. washington, d.c.: hhs.gov/opioids; 2018 may 15 [cited 2019 apr 6]. better research. available from: https://www.hhs.gov/opioids/about-the-epidemic/hhs-response/better-research/index.html 40. national institute on drug abuse [internet]. bethesda: nida; 2019 jan [cited 2019 apr 7]. dramatic increases in maternal opioid use and neonatal abstinence syndrome; [about 1 screen]. available from: https://www.drugabuse.gov/related-topics/trendsstatistics/infographics/dramatic-increases-in-maternal-opioid-use-neonatal-abstinencesyndrome 41. seth p, vivolo-kantor am, o’donnell j. faster data: the cdc-funded enhanced state opioid overdose surveillance program (esoos). 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/123687-5ac0d4a007da5.pdf 42. singleton m, saavedra lg, broad j. states with fast data: lessons learned from kentucky, new mexico and wisconsin. 2018 national rx drug abuse & heroin summit [pdf slides]; u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/123720-5ac0f08038fc5.pdf 43. dunlap lj. expanding access to treatment for opioid use disorder (oud): the role of telehealth. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/1237475ac0f42717ad5.pdf 44. yellowlees p. telemedicine for opioid use disorder. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from https://swoogo.s3.amazonaws.com/uploads/123747-5ac0f42717ad5.pdf 45. zheng w, nickasch m, lander l, wen s, xiao m, et al. 2017. treatment outcome comparison between telepsychiatry and face-to-face buprenorphine medication-assisted treatment for opioid use disorder: a 2-year retrospective data analysis. j addict med. 11(2), 138-44. doi:. pubmed https://doi.org/10.1097/adm.0000000000000287 46. humphreys k. americans use far more opioids than anyone else in the world. the washington post [internet]. 2017 mar 15 [cited 2019 apr 7]. available from: https://www.washingtonpost.com/news/wonk/wp/2017/03/15/americans-use-far-moreopioids-than-anyone-else-in-the-world/?utm_term=.0fbfb0c86f30 47. humphreys k. americans take more pain pills but not because they are in more pain. the washington post [internet]. 2018 mar 23 [cited 2019 apr 7]. available from: https://www.washingtonpost.com/news/wonk/wp/2018/03/23/americans-take-more-painpills-but-not-because-theyre-in-more-pain/?utm_term=.5aea8e534bb3 48. office of inspector general. opioids in medicare part d: concerns about extreme use and questionable prescribing. hhs oig data brief [internet]. 2017 jul [cited 2019 apr 7]; [about 10 p.]. available from: https://oig.hhs.gov/oei/reports/oei-02-17-00250.pdf 49. centers for disease control and prevention [internet]. atlanta: cdc; 2019 [cited 2019 apr 5]. trends in annual opioid prescribing rates by overall and high-dosage prescriptions; [about 1 screen]. available from: https://www.cdc.gov/templatepackage/contrib/widgets/cdccharts/iframe.html?chost=www. cdc.gov&cpath=/drugoverdose/data/prescribing.html&csearch=&chash=&ctitle=prescriptio n%20opioid%20data%20%7c%20drug%20overdose%20%7c%20cdc%20injury%20ce nter&wn=cdccharts&wf=/templatepackage/contrib/widgets/cdccharts/&wid=cdccharts1& mmode=widget&mpage=&mchannel=&host=www.cdc.gov&displaymode=wcms&config url=/drugoverdose/data/trendschart.json&class=mb-3 50. centers for disease control and prevention [internet]. atlanta: cdc; 2018 oct 3 [cited 2019 apr 5]. opioid overdose: u.s. opioid prescribing rate maps; [about 1 screen]. available from: https://www.cdc.gov/drugoverdose/maps/rxrate-maps.html https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28107210&dopt=abstract https://doi.org/10.1097/adm.0000000000000287 u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 51. nelson ls, juurlink dn, perrone j. 2015. addressing the opioid epidemic. jama. 314(14), 1453-54. doi:. pubmed https://doi.org/10.1001/jama.2015.12397 52. center centers for disease control and prevention [internet]. atlanta: cdc; 2017 oct 3 [cited 2019 apr 7]. opioid overdose: what states need to know about pdmps; [about 1 screen]. available from: https://www.cdc.gov/drugoverdose/pdmp/states.html 53. mcdonald jv. what do you do, when a patient violates a pain agreement? rhode island department of public health [internet]. 2015 jun 10 [cited 2019 apr 7]; [about 10 p.]. available from: http://www.health.ri.gov/publications/guidelines/provider/patientviolatespainagreement.pd f 54. kolodny a. changing prescribing practices to prevent opioid addiction. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/123732-5ac0f21bf0064.pdf 55. volkow nd, mclellan ta, cotto jh, karithanom m, weiss sr. 2011. characteristics of opioid prescriptions in 2009. jama. 305(13), 1299-301. doi:. pubmed https://doi.org/10.1001/jama.2011.401 56. miech r, johnston l, o’malley pm, keyes km, heard k. 2015. prescription opioids in adolescence and future opioid misuse. pediatrics. 136(5), e1169-77. doi:. pubmed https://doi.org/10.1542/peds.2015-1364 57. pew [internet]. philadelphia: the pew charitable trusts; c1996-2019 [cited 2019 apr 7]. when are prescribers required to use prescription drug monitoring programs? data show mandates vary across states; [about 1 screen]. available from: https://www.pewtrusts.org/en/research-and-analysis/data-visualizations/2018/when-areprescribers-required-to-use-prescription-drug-monitoring-programs 58. az.gov. [internet]. phoenix: arizona state board of pharmacy; 2019 [cited 2019 apr 7]. available from https://pharmacypmp.az.gov/ 59. appriss health [internet]. data submission guide for dispensers. michigan automated prescription system. 2019 mar [cited 2019 apr 7]; [about 3 p.]. available from: https://www.michigan.gov/documents/lara/mi_data_submission_dispenser_guide_576262 _7.pdf 60. rasubala l, pernapati l, velasquez x, burk j, ren yf. 2015. impact of a mandatory prescription drug monitoring program on prescription of opioid analgesics by dentists. plos one. 10(8), e0135957. doi:. pubmed https://doi.org/10.1371/journal.pone.0135957 61. paulozzi lj, kilbourne em, desai ha. 2011. prescription drug monitoring programs and death rates from drug overdose. pain med. 12(5), 747-54. doi:. pubmed https://doi.org/10.1111/j.1526-4637.2011.01062.x https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26461995&dopt=abstract https://doi.org/10.1001/jama.2015.12397 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21467282&dopt=abstract https://doi.org/10.1001/jama.2011.401 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26504126&dopt=abstract https://doi.org/10.1542/peds.2015-1364 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26274819&dopt=abstract https://doi.org/10.1371/journal.pone.0135957 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21332934&dopt=abstract https://doi.org/10.1111/j.1526-4637.2011.01062.x u.s. opioid epidemic: impact on public health and review of prescription drug monitoring programs (pdmps) online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e18, 2019 ojphi 62. patrick sw, fry ce, jones tf, buntin mb. 2016. implementation of prescription drug monitoring programs associated with reductions in opioid-related death rates. health aff (millwood). 35(7), 1324-32. epub jun 2016. doi:. pubmed https://doi.org/10.1377/hlthaff.2015.1496 63. centers for disease control and prevention [internet]. integrating & expanding prescription drug monitoring program data: lessons from nine states. 2017 feb [cited 2019 apr 7]; [about 12 p.]. available from https://www.cdc.gov/drugoverdose/pdf/pehriie_report-a.pdf 64. bridwell l, sargent w, murzynski s, vinciguerra j. advancing science into action: enhancing pdmps and ehrs. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/123719-5ac0f065ef827.pdf 65. mcdonald jv. rhode island prescription drug monitoring clinical alerts: preliminary effects on prescribing. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/1237145ac0ef78c9035.pdf 66. u.s. food & drug administration. fda requires strong warnings for opioid analgesics, prescription opioid cough products, and benzodiazepine labeling related to serious risks and death from combined use. fda news release [internet]. 2016 aug 31 [cited 2019 apr 7]. available from: https://www.fda.gov/news-events/press-announcements/fda-requires-strongwarnings-opioid-analgesics-prescription-opioid-cough-products-and-benzodiazepine 67. losby j, wally m, hsu j. using ehr-based clinical decision supports to affect opioid prescribing behavior. 2018 national rx drug abuse & heroin summit [pdf slides]; 2018 apr 2-5; atlanta, ga. available from: https://swoogo.s3.amazonaws.com/uploads/1237305ac0f1d799386.pdf 68. seymour rb, leas d, wally mk, hsu jr. 2016. primum group. prescription reporting with immediate medication utilization mapping (primum): development of an alert to improve narcotic prescribing [erratum in: bmc med inform decis mak. 2016;16] [1] [:125. pubmed pmid: 27549364; pubmed central pmcid: pmc4994311]. bmc med inform decis mak. 16(1), 125. doi:. pubmed https://doi.org/10.1186/s12911-016-0364-6 69. world health organization [internet]. geneva: who; 2019 [cited 2019 apr 7]. constitution; [about 1 screen]. available from https://www.who.int/about/who-we-are/constitution 70. silva d. prince died after taking fake vicodin laced with fentanyl, prosecutor says. nbc news [internet]. april 19. 2018 apr 19 [cited 2019 apr 7]. available from: https://www.nbcnews.com/news/us-news/no-criminal-charges-prince-s-overdose-deathprosecutor-announces-n867491 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27335101&dopt=abstract https://doi.org/10.1377/hlthaff.2015.1496 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27670911&dopt=abstract https://doi.org/10.1186/s12911-016-0364-6 bridging the communication gap: successes and challenges of mobile phone technology in a health and demographic surveillance system in northern nigeria online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 bridging the communication gap: successes and challenges of mobile phone technology in a health and demographic surveillance system in northern nigeria henry v. doctor, phd 1,2* , alabi olatunji, msc 3 , and abdul’azeez jumare, pgd comp sc 4,5 1 columbia university, mailman school of public health, department of population & family health, new york, usa 2 prrinn-mnch program, operations research unit, abuja, nigeria 3 prrinn-mnch program, operations research unit, gusau, zamfara state, nigeria 4 prrinn-mnch program, operations research unit, gusau, zamfara state, nigeria 5 ahmadu bello university, department of community medicine, zaria, nigeria abstract maternal and child health indicators are generally poor in nigeria with the northern part of the country having the worst indicators than the southern part. efforts to address maternal and health challenges in nigeria include, among others, improvement in health and management information systems. we report on the experience of mobile phone technology in supporting the activities of a health and demographic surveillance system in northern nigeria. our experience calls for the need for the nigerian government, the mobile network companies, and the international community at large to consolidate their efforts in addressing the mobile network coverage and power supply challenges in order to create an enabling environment for socio-economic development particularly in rural and disadvantaged areas. unless power and mobile network challenges are addressed, health interventions that rely on mobile phone technology will not have a significant impact in improving maternal and child health. keywords: public health surveillance systems; public health informatics; nigeria introduction the reported maternal and child health (mch) indicators in nigeria are generally poor. in particular, mch indicators from northern nigeria are worse. for example, the maternal mortality ratio (mmr) in the north is much higher than the national average, exceeding 1,000 per 100,000 live births compared to fewer than 300 per 100,000 live births for the southern region [1]. recent studies have revealed that the mmr in nahuche area of zamfara state in north west (nw) nigeria is 1,049 deaths per 100,000 live births [2]. child mortality estimates are also high as evidenced by the under-five mortality in nigeria which was estimated at 143 per 1,000 live births in 2010 [3]. efforts to address these challenges range from interventions aimed at improving the quality and access to maternal, newborn, and child health services by strengthening planning and http://ojphi.org/ online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 training of human resource for health, improving the state of health infrastructure, provision of supplies and commodities (including drugs), and community engagement to promote appropriate mch behavior and increase demand for maternal health services in general and in particular emergency obstetrics care. the partnership for reviving routine immunization in northern nigeria (prrinn); maternal, newborn, and child health (mnch) program (hereafter ‘prrinn-mnch program’), received funding from the united kingdom department for international development (dfid) and the norwegian government between 2007 and 2008 to revitalize immunization, improve the quality, access, and utilization of maternal, newborn, and child health services in northern nigeria. the program was initiated by a consortium consisting of health partners international (uk), save the children (uk), and grid consulting (nigeria) and operates in four states in northern nigeria: jigawa, katsina, yobe, and zamfara. part of the comprehensive activities of the prrinn-mnch program includes setting up a health and demographic surveillance system (hdss) in nahuche emirate of bungudu local government in zamfara state of north west nigeria. in collaboration with the zamfara state government, the nahuche hdss (nhdss) was established to provide a platform for measuring the impact of the program’s interventions and also as a platform for future surveys and trials. a detailed description of the nhdss set up, design, data collection, and processing procedures has been described elsewhere [4]. the set up activities of the nhdss included a pilot census in may/june 2009 followed by a baseline census (sept-dec 2010) and bi-annual cycles of data collection beginning in january 2011. trained interviewers collect routine data in rural communities under surveillance on pregnancies, births, deaths, migration, marriages, and vaccination coverage. these data are recorded in registers and reported to the nhdss computer centre for processing. trained community key informants (ckis volunteers) support the nhdss data collection activities by routinely reporting key events such as births and deaths as they occur in their communities. as of june 2012, nhdss had a surveillance population of about 138,000 located in 20,194 households. in order to determine the probable cause of deaths occurring at the community level, the nhdss initiated the verbal autopsy data collection system in october 2012. the data collection and processing activities of nhdss follow the guidelines of the international network for the demographic evaluation of populations and their health (indepth network). the indepth network is an umbrella body which provides an international platform of sentinel demographic sites that provides health and demographic data and research to enable developing countries to set health priorities and policies based on longitudinal evidence. as of november 2012, the network consisted of 44 hdss sites in selected countries in africa, asia, and oceania [5]. mobile communication infrastructure and surveillance operations while the hdss sites provide data aimed at measuring the impact of interventions and systems to monitor progress towards achieving health-related national goals, the hdss sites are set up in countries with varying degrees of infrastructure. except in a few cases, such as nairobi hdss in kenya (focusing on urban slums), virtually all hdss sites are in rural and under-resourced settings. while a summary of the cross-country variations in the infrastructure of communities http://ojphi.org/ online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 with hdss sites is beyond the scope of this paper, we focus on the infrastructure of nhdss in northern nigeria with respect to its mobile communication capacity in supporting data collection, field management, and data processing activities. in brief, nahuche study area consists of 306 villages under the leadership of six district heads of bella, gada, karakkai, nahuche keku, nahuche ubandawaki, and rawayya. literacy levels are very low and infrastructure such as road network, power generation and supply, is inadequate. the general sanitation in the area is poor and the area has a warm climate with temperatures rising to 38 degrees celcius from march to may. farming is the most common economic activity and unemployment is rampant with associated temporary labor migration of men [4]. nahuche is benefiting from the substantial growth in mobile telephone subscriptions that has occurred since the 1980s in both developing and developed countries [6]. for example, the nhdss baseline census of 2010 showed that 40.3% of 19,193 households within the surveillance area had access to a mobile phone. of interest is the fact that in much of sub saharan africa there are more mobile phones than fixed lines [6] and nigeria is no exception, mobile phone subscriptions have grown. since the liberalization of nigeria’s telecommunication sector in 2000, the industry has become the key source of new jobs in the economy, employing about 6,000 professionals, and overseeing, indirectly close to half a million jobs [7]. the increases in mobile coverage has many more advantages such as improving what people already do in terms of faster and cheaper communication. for example, in india, fishermen can reduce fish wastage by phoning in advance coastal markets to find out the need for supply. mobile banking also offers the flexibility and convenience for many customers [7]. the increase in mobile telephones has also led to a growing attraction for mobile telephones as health interventions. this attraction has been influenced by, among other things, the fact that mobile phones are functionally easier to use for people with lower levels of skills than those needed for computers or the internet [6]. irrespective of whether mobile phones are functionally easier to use for those with lower level or higher level skills, mobile phones have become useful in data collection of health-related information. in the northern nigeria hdss at nahuche, and just as in many other hdss sites, fieldworkers are expected to communicate to a large extent with the field office-based team and to a minor extent with the data processing team on a daily basis to resolve any data collection problems that may arise in order to expedite data processing activities. however, many times the field-based and office-based teams have problems in communicating with each other due to poor mobile network coverage but also due to limited power supply when the mobile phone batteries gets discharged. the nhdss study area has virtually no electricity supply from the national grid and majority of households rely on electricity from rechargeable lamps for lighting. for example, the baseline census results on household characteristics conducted in 2010 in nhdss revealed that 2.5% of the 19,193 households had access to electricity from the national grid and another 0.5% from electric generators [8]. the nhdss fieldworkers come from households or communities which struggle to access electricity. while field supervisors are expected to visit the fieldworkers on a daily basis in the surveillance areas, field problems that emerge after the supervisors’ visits can only be addressed during the subsequent visits by the supervisors or whenever the fieldworkers have enough power on their mobile phones. a more proactive way would be for fieldworkers to fully charge their mobile phones and ensure that they have enough power each and every morning before they start http://ojphi.org/ online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 their work. however, at least within the nhdss operational setting, fieldworkers are not provided with official mobile phones. as a result, even with a fully charged mobile phone in the morning, they can make and receive calls from their friends and family members. by the time they start making or receiving official phone calls, the mobile phones are on average discharged. even if they had access to an official mobile phone, recharging the phones would still be a major challenge. the ckis also experience similar challenges in mobile communication. while the nhdss office-based team is able to recharge their mobile phones using power from a generator, they are often unable to communicate with their field staff. we are aware of alternative options to charge mobile phone batteries such as mini solar chargers but their efficacy and duration of charging varies. some of the available solar panels do not provide optimal solar power during the rainy season. what is needed is a more permanent solution: regular supply of power for community members in nahuche and nigeria at large. this is inevitable since the application of mobile health technology or intervention relies, among other things, on the ability of users to have constant power supply for recharging. while the nhdss efforts to expedite data collection and processing are compromised by the virtually non-existent power supply, future efforts to link the hdss activities with those of the adjacent nahuche health research centre in tracking immunization defaulters through mobile phone technology (i.e., alerts on service uptake) will be challenging. in addition to the very limited power supply is the poor mobile network coverage across many parts of nigeria. intermittent mobile network from the providers contributes to the high discharge rate of mobile phones since subscribers often have to keep trying a line for several times before they get connected. eventually, some of the mobile phone subscribers in the nhdss study area end up forgetting (except those who are able to save their numbers elsewhere) their mobile numbers since the network coverage is virtually non-existent. our team has experienced this during data collection of migration events. a respondent who reports that some of the household’s members have migrated to another area is asked for the mobile phone number of the migrant. in many instances, fieldworkers are not able to get the mobile numbers because the respondents do not know the numbers. when asked reasons for not knowing the numbers, majority of them sarcastically state that there is no need to know the number since there is no mobile network coverage in their area unless they go to the zamfara state capital, gusau. related to the poor mobile network coverage are the high tariff charges on communication. our field workers often complain about high tariff on airtime recharge cards. they are often unable to call the field office at the nahuche research centre due to insufficient airtime on their mobile phones. while high tariff charges can be managed through budgetary allocation for airtime purchases, the power supply and mobile network coverage remain an enormous challenge for field operations. future outlook while we are very optimistic with the effectiveness of mobile technology in the future, health intervention packages, which take advantage of mobile phone technology, are currently a nonhttp://ojphi.org/ online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 starter in majority of rural communities in nigeria. how can this problem be addressed? the answer is simple but doing it is an enormous task. mobile health technologies would require constant power supply and strong network coverage in all communities. nigeria’s power supply is currently erratic and insufficient. generally, there is no difference between the rural and the urban areas except for the fact that the urban areas by virtue of their status as ‘business hubs’ tend to push consumers to use electric generators more than often the rural areas. as reported earlier, only 0.4% of the households in the nhdss baseline census in 2010 had access to electricity from generators. while this is likely to be representative of most rural communities in northern nigeria, efforts to seek alternative solutions for power generation are inevitable. the government of nigeria through various media has acknowledged the need to find alternative solutions to generate more power for the populace. for example, according to a newspaper report on october 3, 2011, the director general of the energy commission of nigeria, prof. abubakar sambo, stated that 1% of nigeria’s land area could be used to generate 600,000 megawatts of electricity using solar energy [9]. solar energy, described as the best form of renewable energy, has a very high investment cost but the life span of the solar panel could be as long as 25 years if they are properly installed. nevertheless, some anecdotal evidence shows that in some states in nigeria solar panels have failed to deliver the expected results due to corrupt practices associated with procurement of substandard panels. irrespective of this, solar energy is never exhausted unlike the conventional energy of oil, coal, and gas. while some newspapers in september 2012 reported that some petrol (or gas) stations are reporting declines in their sales due to improved power supply [10], the saturation effects of the increased power generation will take a considerable time to be felt by all nigerians. the reported increase in power generation, estimated at slightly over 4,000 megawatts as of october 2012, is welcome and will support a lot of business and service delivery activities that rely on power. while the backbone of the nhdss field operations relies on mobile technology, there is a need for organizations and stakeholders involved in improving mch outcomes in northern nigeria and similar settings to find alternative solutions to address power problems in the intervention areas. the role of power supply in improving mch cannot be overemphasized in the contemporary world. drugs or vaccines need to be stored in a cool place (considering the warm weather in nigeria for a greater part of a year), surgery and other treatment rooms need power, lower level health facilities need to communicate with referral facilities on the need for an ambulance, and many others. to overcome this challenge, the prrinn-mnch program has rehabilitated a number of health facilities in its program states and installed solar panels to ensure constant power supply in all critical areas of health facility operations. from an operations point of view, mobile technology is critical for nhdss activities. field staff, field management, and data processing teams are expected to be in constant communication to report and resolve problems instantly and ensure rapid processing and dissemination of data to policy makers and other stakeholders. to-date, the success of mobile phones in aiding nhdss fieldwork operations has been dismal. as we get closer to the deadline for achieving the millennium development goals in 2015, the most realistic priority in ensuring the effectiveness of mobile technology in field operations as well as any mobile phone-based health care interventions is to ensure that communities have regular access to power. the nhdss has set up a system of routine monitoring of health and population dynamics in nahuche area in northern http://ojphi.org/ online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 nigeria. however, electricity power supply remains an enormous challenge particularly with recent developments within the indepth network in which some hdss sites are piloting activities to migrate hdss data collection from the traditional and expensive paper-based method to the less expensive mobile-based data collection using devices such as mobile phones or tablets. these devices need constant power supply to charge the batteries since the speed of data collection and processing will depend, among other things, on sufficient power supply for the mobile devices. conclusion what is the future of power generation in nigeria? from the local media, we hear of increased power generation although the actual reported megawatts vary from one source to the other. nevertheless, nigeria’s power sector reform initiative which was launched in 2005, recognizes the need to improve power sector performance as a critical step in its efforts to address development challenges. through the 2010 roadmap, nigeria revitalized the challenging process of implementing reforms by outlining the government’s strategy and actions to undertake comprehensive power sector reform to expand supply, open the door to private investment, and address some of the chronic sector issues hampering improvement of service delivery [11]. we know that power supply is one of the many challenges nigeria is expected to address to ensure that the country is on course to meet the mdgs, particularly those related to health. increased power supply will strengthen, among other things, health management information systems of which the nhdss is part. we hope that the nigerian government, the mobile network companies, and the international community at large will consolidate their efforts in addressing the mobile network coverage and power supply challenges in order to create an enabling environment for socio-economic development particularly in rural and disadvantaged areas. acknowledgments we are most grateful to the people of nahuche emirate in bungudu local government, zamfara state for their committment to the nahuche hdss activities since 2009. we also acknowledge the support of traditional and political authorities. the nahuche hdss has been set up with technical support from consultants from the indepth network (through navrongo and kintampo hdss sites in ghana) and columbia university through the operations research technical assistance unit of prrinn-mnch programme. the department for international development (uk), the norwegian government, zamfara state and bungudu local governments are acknowledged for their financial assistance. the entire prrinn-mnch management, nahuche field, and data management team are acknowledged for their continued cooperation and support. corresponding author henry victor doctor associate research scientist columbia university, mailman school of public health e-mail: hvd2105@columbia.edu http://ojphi.org/ mailto:hvd2105@columbia.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 references [1] centre for reproductive rights and women advocates research and documentation centre. (2008). broken promises: human rights, accountability, and maternal death in nigeria. new york, lagos: crr, wardc. [2] doctor, h.v., olatunji, a., findley, s.e., afenyadu, g.y., abdulwahab, a. and jumare, a. (2012). maternal mortality in northern nigeria: findings of a health and demographic surveillance system in zamfara state, nigeria. tropical doctor, 42, 140-143. [3] unicef. (2011). levels and trends in child mortality – 2011 report. new york: unicef (on behalf of the united nations inter-agency group for child mortality estimation. [4] doctor, h.v., findley, s.e. and jumare, a. (2011). evidence-based health programme planning in northern nigeria: results from the nahuche health and demographic surveillance system pilot census. journal of rural and tropical public health, 10, 21-28. [5] the indepth network. (2012). brief profiles of member centres. accessed on 1 november 2012 at www.indepth-network.org [6] kaplan, w. (2006). can the ubiquitous power of mobile phones be used to improve health outcomes in developing countries? globalization and health 2:9; doi:10.1186/1744-8603-29 [7] singh, r. (2009). mobile phones for development and profit: a win-win scenario. overseas development institute. united kingdom: overseas development institute. [8] olatunji, a., doctor, h.v., idowu, o., and jumare, a. 2011. a report on the health and demographic surveillance system baseline census. gusau, zamfara state, nigeria: nahuche health research centre. [9] this day online news. 2011. nigeria can generate 600,000mw from solar energy. accessed on 1 november 2012 at http://www.thisdaylive.com/articles/-nigeria-can-generate-600000mw-from-solar-energy-/99738/ [10] sule, t. (2012). petrol station managers see drop in sales as power generation steadies. accessed on 1 november 2012 at http://www.businessdayonline.com/ng/index.php/news/76-hot-topic/44404-petrol-stationmanagers-see-drop-in-sales-as-power-generation-steadies [11] world bank. 2012. nigeria overview: economic overview and performance. accessed on 1 november 2012 http://www.worldbank.org/en/country/nigeria/overview http://ojphi.org/ http://www.indepth-network.org/ http://www.thisdaylive.com/articles/-nigeria-can-generate-600-000mw-from-solar-energy-/99738/ http://www.thisdaylive.com/articles/-nigeria-can-generate-600-000mw-from-solar-energy-/99738/ http://www.businessdayonline.com/ng/index.php/news/76-hot-topic/44404-petrol-station-managers-see-drop-in-sales-as-power-generation-steadies http://www.businessdayonline.com/ng/index.php/news/76-hot-topic/44404-petrol-station-managers-see-drop-in-sales-as-power-generation-steadies http://www.worldbank.org/en/country/nigeria/overview layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts using medications sales from retail pharmacies for syndromic surveillance in rural china weirong yan*1, 2, liwei cheng2, li tan2, miao yu3, shaofa nie2, biao xu3, lars palm4 and vinod diwan1 1karolinska institutet, stockholm, sweden; 2huazhong university of science and technology, wuhan, china; 3fudan university, shanghai, china; 4future position x, gavle, sweden objective to use an unconventional data pharmaceutical sales surveillance for the early detection of respiratory and gastrointestinal epidemics in rural china. introduction drug sales data as an early indicator in syndromic surveillance has attracted particular interest in recent years (1, 2), however previous studies were mostly conducted in developed countries or areas. in china, many people (around 60%) choose self-medication as their first option when they encounter a health problem (3), and electronic sales information system is gradually used by retail pharmacies, which makes drug sales data become a promising data source for syndromic surveillance in china. methods this experimental study was conducted in four rural counties in central china. from apr. 1st 2012, there are 56 retail pharmacies joined the study, including 21 county pharmacies and 35 township pharmacies. 123 drugs were selected under surveillance based on the analysis of local historical sales volume and consultation with local pharmacists, including 19 antibiotics, 15 antidiarrheal medications, 9 antipyretics, 41 compound cold medicine, and 39 cough suppressants. daily sales volume of the selected drugs was recorded into the database by pharmacy staff at each participating unit via electronic file importing or manual entering. figure 1 showed the user interface for data viewing, query and export. field training and supervision were regularly conducted to ensure the data quality. results from apr. 1st to jun. 30th 2012, there were 103814 sales records reported in the system, including 44464 (42.83%) records from county pharmacies and 59350 (57.17%) from township pharmacies. among all surveillance drugs, the sales of compound cold medicine accounted for the largest proportion (43.42%), followed by antibiotics (22.52 %), cough suppressants (18.50%), antidiarrheal drugs (9.49%) and antipyretics (6.06 %). more than 80% data were reported into the system within 24 hours after the sales date, and the reporting timeliness of county pharmacies improved with time (table 1). missing report rate was less than 5% for all surveillance units. several reporting mistakes were found during the first three-month implementation, which might be due to system bugs, data provider unfamiliar with the system especially when manual reporting, data providers’ carelessness, and some pharmacies reluctant to share sales data amongst others. conclusions although the current reporting timeliness and completeness are satisfying, it is noteworthy the quality of data is not stable during the beginning phase of the implementation. further validation of the data will be required. to ensure the accuracy of data and the effective and sustainable deployment of the system, it is imperative to establish a data sharing policy between pharmacies and public health agencies, and achieve automated data collection to avoid additional human labor involvement. table 1: timeliness of reporting records from various pharmacies, apr. 1st jun. 30th, 2012 figure 1 user interface in the system for data viewing, query and export keywords syndromic surveillance; medication sales; developing settings acknowledgments the study is financially supported by a grant under the european union framework program 7 (project no: 241900). references 1. magruder s. evaluation of over the counter pharmaceutical sales as a possible early warning indicator of human disease. johns hopkins apl technical digest 2003;24(4):349-53. 2.das d, metzger k, heffernan r, balter s, weiss d, mostashari f. monitoring over-the-counter medication sales for early detection of disease outbreaks—new york city. mmwr 2005;54 suppl:41-6. 3. wen y, lieber e, wan d, hong y; nimh collaborative hiv/std prevention trial group. a qualitative study about self-medication in the community among market vendors in fuzhou, china. health soc care community. 2011;19(5):504-13. *weirong yan e-mail: weirongy@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e145, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts national collaborative for bio-preparedness meredith arasaratnam*1, 2, david potenziani1, 2, marc hoit3, 1, colleen jenkins4, 1 and charles cairns2, 1 1national collaborative for bio-preparedness, chapel hill, nc, usa; 2university of north carolina, chapel hill, nc, usa; 3north carolina state university, raleigh, nc, usa; 4sas institute, cary, nc, usa objective demonstrate the functionality of the national collaborative for bio-preparedness system. introduction the national collaborative for bio-preparedness (ncb-prepared) was established in 2010 to create a biosurveillance resource to enhance situational awareness and emergency preparedness. this jointinstitutional effort has drawn on expertise from the university of north carolinachapel hill, north carolina state university, and sas institute, leveraging north carolina’s role as a leader in syndromic surveillance, technology development and health data standards. as an unprecedented public/private alliance, they bring the flexibility of the private sector to support the public sector. the project has developed a functioning prototype system for multiple states that will be scaled and made more robust for national adoption. methods ncb-prepared recognizes that the capability of any biosurveillance system is a function of the data is analyzes. ncb-prepared is designed to provide information services that analyze and integrate national data across a variety of domains, such as human clinical, veterinary and physical data. in addition to this one-health approach to surveillance, a primary objective of ncb-prepared is to gather data that is closer in time to the event of interest. ncb-prepared has validated the usefulness of north carolina emergency medical services data for the purposes of biosurveillance of both acute outbreaks and seasonal epidemics (1). a unique model of user-driven valuing of data-providing value back to the provider in their terms-motivates collaboration from potential data providers, along with timely and complete data. ncbprepared approaches potential data providers, partners and users with the proposition that enhanced data quality and analysis is valuable to them individually and that an integrated information system can be valuable to all. with the onboarding of new data sources, ncb-prepared implements a formal process of data discovery and integration. the goal of this process is three-fold: 1) to develop recommendations to enhance data quality going forward, 2) to integrate information across data sources, and 3) to develop novel analytic techniques for detecting health threats. ncb-prepared is committed to both utilizing standard methods for event detection and to developing innovative analytics for biosurveillance such as the text analytics and proportional charts method (tap). the sophisticated analytic functionality of the system, including improved time to detection, query reporting, alert detection, forecasting and predictive modeling, can be attributed to collaboration between analysts from private industry, academia and public health. ncb-prepared followed the formal software development process known as agile development to create the user interface of the system. this method is based on iterative cycles wherein requirements evolve from regular sessions between user groups and developers. the result of agile development and collaborative relationships is a system which visualizes signals and diverse data sources across time and place while providing information services across all levels of users and stakeholders. conclusions lessons learned: 1. understand the functionality of new biosurveillance system, ncb-prepared 2. identify the benefit of creating collaborative relationships with data providers and users 3. appreciate the value of a public/private partnership for biosurveillance and bio-preparedness keywords biosurveillance; analytics; preparedness; emergency references cairns c., potenziani d., hoit m., jenkins c., edgemon s. novel approach to statewide biosurveillance using emergency medical services (ems) information. emerg health threats j 2011; 4, doi: 4: 10.3402/ehtj.v4i0.11183 (abstract). *meredith arasaratnam e-mail: arasarat@med.unc.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e198, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts effectiveness of the 2011-12 influenza vaccine: data from us military dependents and us-mexico border civilians damaris padin*, anthony hawksworth, peter kammerer, erin mcdonough and gary brice operational infectious diseases, naval health research center, san diego, ca, usa objective to assess effectiveness of the influenza vaccine among us military dependents and us-mexico border populations during the 2011-12 influenza season. introduction as a result of antigenic drift of the influenza viruses, the composition of the influenza vaccine is updated yearly to match circulating strains. consequently, there is need to assess the effectiveness of the influenza vaccine (ve) on a yearly basis. ongoing febrile respiratory illness (fri) surveillance captures data and specimens that are leveraged to estimate influenza ve on an annual basis. methods data from ongoing fri surveillance at us military and us-mexico border clinics were used to estimate ve. we conducted a case– control study between weeks 3 and 17 of the 2011-12 influenza season. specimens were collected from individuals meeting fri case definition (fever ! 100.0 f with either cough or sore throat). cases were laboratory confirmed influenza infection and controls were negative for influenza. interviewer-administered questionnaires collected information on patient demographics and clinical factors and vaccination status. logistic regression was used to calculate the crude and adjusted odds ratios (or) and ve was computed as (1-or) x 100%. vaccine protection was assumed to begin 14 days post-vaccination. results a total of 155 influenza positive cases and 429 influenza negative controls were included in the analysis 72 cases were influenza a(h3n2), 38 cases were influenza a(h1n1), and 45 cases were influenza b. overall adjusted ve against laboratory-confirmed influenza was 46% (95% ci, 19–64%); unadjusted was 39% (95% ci, 11–58%). influenza subtype analyses revealed moderate protection against a/h3 and a/h1 and lower protection against b. lowest estimated ve was seen in older individuals, age 65 and older. conclusions influenza vaccination was moderately protective against laboratory confirmed influenza in this population. continued surveillance is important in monitoring the effectiveness of the influenza vaccine. keywords influenza; vaccine efficacy; influenza-like illness surveillance acknowledgments the authors gratefully acknowledge the work of on-site research assistants and nhrc laboratory staff who produced the data used in this analysis. we also thank global emerging infections system (geis) division of the armed forces health surveillance center (afhsc) for their support of fri surveillance. *damaris padin e-mail: damaris.padin@med.navy.mil online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e5, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluating a social network analytic tool to support outbreak management and contact tracing in an outbreak of pertussis esther munene*, s. mottice and j. reid utah department of health, slc, ut, usa objective to determine the feasibility and value of a social network analysis tool to support pertussis outbreak management and contact tracing in the state of utah. introduction pertussis (i.e., whooping cough) is on the rise in the us. to implement effective prevention and treatment strategies, it is critical to conduct timely contact tracing and evaluate people who may have come into contact with an infected person. we describe a collaborative effort between epidemiologists and public health informaticists at the utah department of health (udoh) to determine the feasibility and value of a network-analytic approach to pertussis outbreak management and contact tracing. methods the partnership: in early 2012, epidemiologists from udoh’s vaccine preventable disease program and udoh’s public health informaticists formed a partnership to determine the feasibility and value of the organizational risk analyzer (ora) in pertussis outbreak management and contact tracing (1). both entities have a longstanding partnership. a characteristic that has made the collaboration particularly strong and mutually beneficial is that both partners have expertise in disease surveillance and outbreak management. in addition, the informaticists have expertise in devising systems that help frontline healthcare providers. the organizational risk analyzer (ora): ora is a computational tool that extends network analysis by using a meta-matrix model. a meta-matrix is defined as a network of connecting entities. the tool uses one or more matrices in an organization’s meta-matrix as input. from this input the tool calculates measures that describe the relationships and ties among the entities. ora contains over 50 network and node level measures which are categorized by the type of risk they detect (1). procedures: following approval from udoh’s institutional review board, we analyzed records from 629 deidentified pertussis patients from the ut-nedss database from january 2011 to december 2011. the test data included demographics and epidemiological information. we used excel to create .csv data files, uploaded the data into ora, and displayed the data in meta-matrices consisting of nodes (cases/contacts) and edges (relationships). we used ora’s visualizer to check for data-entry errors before performing the network analysis. data analysis: ora’s centrality measures (degree, closeness, betweenness, hub, and eigenvector) were used to identify geographic locations with high infection rates and the patients who were central to sustaining the outbreak. next, we applied a concor algorithm to find groups in the meta-network that might be hard to spot visually. visualizations were used to supplement the metrics. results the ora analysis identified 5 individuals who were central to perpetuating the outbreak in that their centrality measures were higher than other patients in the network. the index patient (fig 1) was traced back to utah county and was linked to 6 direct contacts in the same county and several indirect ties in adjacent counties. the individual was highly connected to others within the network (hub centrality = 1.41 and eigenvector centrality = 1.00). salt lake county had the highest number of cases, followed by utah county and weber county. the concor analysis revealed hidden networks, including a cluster of patients grouped by age group and case status (fig 2). conclusions the ora was found to be a valuable tool for supporting pertussis outbreak management and contact tracing. although network analysis is relatively new to public health, it can increase public health’s understanding of how patterns of social relationships can aid or inhibit the spread of communicable diseases and provide the information needed to target intervention efforts effectively. fig. 1. the index case. fig. 2. concor cluster of patients, by age group and case status. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e72, 2013 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts keywords surveillance; informatics; social network analysis acknowledgments this study was supported in part by the cste applied public health informatics fellowship program and funded by the cdc. references 1. organizational risk analyzer: center for analysis of social and organizational systems 2008. *esther munene e-mail: emunene@utah.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e72, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts synergies between human and animal health syndromic surveillance: triple-s outputs céline dupuy*1, jean-baptiste perrin1, anne bronner1, didier calavas1, pascal hendrikx2 and anne fouillet3 1french agency for food, environmental and occupational health safety (anses), lyon, france; 2french agency for food, environmental and occupational health safety (anses), maisons-alfort, france; 3french institute for public health surveillance (invs), saint-maurice, france objective the objective of this study, based on the triple-s project outputs, was to present the existing synergies between human and animal health syndromic surveillance (sys) systems in europe and a proposal to enhance this kind of collaboration. introduction the triple-s project (syndromic surveillance systems in europe, www.syndromicsurveillance.eu), co-financed by the european commission and involving twenty four organizations from fourteen countries was launched in september 2010 with the following objectives 1) performing an inventory of existing or planned sys systems in europe both in animal and public health, 2) building a network of experts involved in sys 3) producing guidelines to implement sys systems, 4) developing synergies between human and animal health sys systems. the project is based on a cooperation between human and animal health experts, as supported by the one health initiative [1]. methods a network of european experts involved in sys was identified through the triple-s inventory of sys systems. a meeting of human health experts was organized back to back with a similar meeting with animal health experts in paris, september 12-14, 2011. a joint session human/animal health allowed experts to discuss the interest of synergies between both sides. the objectives were to 1) encourage experience and knowledge transfer, 2) discuss what and how information should be shared between both sides to improve respective performances. results the results of the inventory of veterinary sys systems showed that 40% of identified systems already shared or had planned to share information with human health sector. for these systems the collaboration between human and animal health sectors consisted in meetings on a regular basis to discuss the surveillance results. discussions during the triple-s meeting highlighted two reasons for enhancing synergies between both sides. first human health and animal health epidemiologists face common statistical and epidemiological issues when dealing with sys, i.e. use of data collected for other purpose than surveillance; standardization of clinical observations; syndrome definition; anomaly detection; interpretation of unspecific signals; response to alerts. both sides have thus interest in sharing their experiences and knowledge to improve their respective systems. second, systems on both sides have similar objectives and target health events potentially threatening both animal and human populations: zoonoses, extreme weather events, environmental / food contamination, bioterrorist attack... for those events, animal population can play the role of sentinel for human population. regular information flow between human and animal sys could thus enhance the timeliness and sensitivity of sys systems for detecting unexpected health events. moreover, sharing information could help animal and human health experts to interpret and confirm unspecific signals, and confirm the impact of common health threats. all participants of the meeting agreed on the idea to routinely share outputs of the systems but were sceptical about sharing raw data to perform global analysis. conclusions each aspect of the triple-s project includes both human and animal health and will thus contribute to build natural collaboration between both sides. such a project has demonstrated that scientific community is more and more willing to collaborate beyond the boundaries of these two health fields. synergies between human and animal health seem as necessary for syndromic surveillance as it is for traditional surveillance, if not more. they seem especially important for the detection of emerging zoonotic threats but not only. sharing surveillance outputs from both sides would be the first step of collaboration but deeper synergy, e.g. sharing data and analyse them globally, could also be considered. triple-s guidelines for implementation of sys systems in europe will take into account and promote synergies between human and animal health. keywords syndromic surveillance; synergy; early warning acknowledgments the authors thank all participants to the triple-s project activities. references 1.zinsstag, j., et al., potential of cooperation between human and animal health to strengthen health systems. the lancet, 2005. 366(9503): p. 2142-2145. *céline dupuy e-mail: celine.dupuy@anses.fr online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e158, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluation of integrated disease surveillance and response (idsr) using bacillary dysentery as a priority disease, tanzania, 2012 alfred g. mwanyika*1, senga sembuche1 and agricola joachim2 1tanzania field epidemiology and laboratory training program (tfeltp), dar es salaam, united republic of tanzania; 2muhimbili university of health and allied sciences (muhas), dar es salaam, united republic of tanzania objective to determine whether the idsr system meets its purpose and objectives, to evaluate the system attributes, and provide recommendations to improve the idsr system, using the example of bacillary dysentery, a priority disease in tanzania. introduction each year ministry of health and social welfare of tanzania under epidemiology section has been reporting many suspected cases of shigella throughout the country. however only fewer laboratories have been reporting the confirmed cases. methods the study was conducted between november 2011and february 2012.hospital staff including nurses, physicians and laboratory personnel and other stakeholders from the ministry of health and social welfare (mohsw) were enrolled in the study. data was collected from a review of documents, questionnaires and interview of stakeholders. surveillance system attributes were evaluated using updated guidelines for evaluating public health surveillance system (2007) from morbidity and mortality weekly report (mmwr). results questionnaires were administered to fifteen health personnel from four regional hospitals. four health staff from epidemiology and laboratory section of mohsw were interviewed. only one regional hospital laboratory was conducting laboratory diagnosis for bacillary dysentery and sending reports to mohsw. data from this laboratory was reviewed. out of 641 records from bacillary dysentery testing, 271 (42.3%) did not include age data, 5 (0.78%) missed sex, 624 (97.3%) missed the district where the patient came from, 26 (4.4%) did not include information on specimen quality, 1(0.2%) had no report of pathogens found and 636 (99.2%) did not include antimicrobial sensitivity testing (ast). the predictive value positive (pvp) of the system was 0.62%. one (6.7%) of the health workers was trained in idsr. conclusions idsr in tanzania generally is not performing well as only one (25%) of the four visited hospitals conducts and reports laboratory diagnosis of bacillary dysentery. however the system is representative as it covers all regions of the united republic of tanzania and all ages of people. the system is flexible since national idsr guideline (2001) was revised in 2011. more emphasis should be placed on strengthening laboratory capacity in disease diagnosis and reporting at all levels. keywords surveillance; evaluation; idsr; bacillary dysentery acknowledgments we acknowledge tfeltp and regional hospitals for their corporations to achieve this study. references monthly diseases reports. ministry of health and social welfare of tanzania. www.moh.go.tz *alfred g. mwanyika e-mail: geofalfred@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e132, 2013 immunization registries in the emr era 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi immunization registries in the emr era lindsay a. stevens 1,2 , jonathan p. palma 1,2 , kiran k. pandher 3 , christopher a. longhurst 1,2 1 department of pediatrics, stanford university school of medicine, stanford, california, 2 department of clinical informatics, lucile packard children's hospital, palo alto, california, 3 department of information services, lucile packard children's hospital, menlo park, california abstract background: the cdc established a national objective to create population-based tracking of immunizations through regional and statewide registries nearly 2 decades ago, and these registries have increased coverage rates and reduced duplicate immunizations. with increased adoption of commercial electronic medical records (emr), some institutions have used unidirectional links to send immunization data to designated registries. however, access to these registries within a vendor emr has not been previously reported. purpose: to develop a visually integrated interface between an emr and a statewide immunization registry at a previously non-reporting hospital, and to assess subsequent changes in provider use and satisfaction. methods: a group of healthcare providers were surveyed before and after implementation of the new interface. the surveys addressed access of the california immunization registry (cair), and satisfaction with the availability of immunization information. information technology (it) teams developed a “smart-link” within the electronic patient chart that provides a single-click interface for visual integration of data within the cair database. results: use of the tool has increased in the months since its initiation, and over 20,000 new immunizations have been exported successfully to cair since the hospital began sharing data with the registry. survey data suggest that providers find this tool improves workflow and overall satisfaction with availability of immunization data. (p=0.009). conclusions: visual integration of external registries into a vendor emr system is feasible and improves provider satisfaction and registry reporting. key words: electronic medical records, immunization registries, emr integration, hitech, meaningful use abbreviations: california immunization registry (cair), computerized physician order entry (cpoe), electronic medical record (emr), health information technology for economic and clinical health act (hitech), health level 7 (hl7), immunization information system (iis), information technology (it), lucile packard children's hospital (lpch) immunization registries in the emr era 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi introduction since their inception nearly 20 years ago, immunization registries have been shown to increase vaccine coverage rates and decrease duplicate immunizations. 1-3 the cdc provides funding for immunization information system (iis) programs in all 50 states. 4 as part of the health information technology for economic and clinical health act (hitech) of 2009, providers with electronic medical records (emrs) are encouraged to submit electronic immunization data to iiss to achieve meaningful use. 4-6 many institutions have established unidirectional interoperability by which their emr immunization records are uploaded to a designated registry—thereby preventing the need for staff to manually update each patient chart in the registry. 5-1 bidirectional interoperability is preferable as it would allow accurate immunization data from the iis to be sent directly to the hospital’s or practice’s emr, however integration is expensive and difficult to implement. 11 visual integration into the emr with context-sensitive access can meet clinician needs without the expense of bidirectional data integration. lucile packard children's hospital (lpch) has a strong history of developing informaticsenabled innovations. 12-16 lpch had not, however, previously participated in the statewide immunization registry, the california immunization registry (cair), largely due to concerns for duplication of efforts by clinical staff who would need to manually enter the same data in both the vendor emr and the iis. the previous system was paper-based and involved scanning copies of the patient records in to the emr. no immunization information was tracked directly in our emr. this information was not complete and only contained data for those immunizations recorded at lpch. the few published reports on bidirectional registries involved health level 7 (hl7) web service, which have not been widely replicated given that the technical work involved is far greater and difficult to sustain. 17, 18 decision support services in the emr are much more limited as the compared to those native in the registries. our team’s goal was to develop a visually integrated interface by which clinical staff could quickly and easily access the registry to evaluate a patient’s immunization history from within our emr. it was hypothesized that initiating the association between lpch and cair would add to the number of patients included in the iis, increase provider utilization of this tool, and improve provider satisfaction and perceived efficiency. correspondence: lindsay.stevens@stanford.edu copyright ©2013 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. immunization registries in the emr era 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi methods integration creation of the visually integrated registry interface within the vendor emr required two different efforts. the first was to upload hospital immunization data to the iis, transferring nightly any new immunizations recorded at lpch using hl7 code. historical data, including all immunizations previously ordered using computerized physician order entry (cpoe) from, were also uploaded. the second aspect was to create a “smart link” – a web-based icon in the “patient summary” area of the chart that directs providers to the cair registry site. (figure 1). clicking this link sends patient identifiers to the cair database, using an institutional login to access the patient’s cair chart. the cair interface includes both immunizations from lpch data uploads and any others added to the database by outside institutions, as well as its native decision support tool. (figure 2). the new interface was implemented at the end of the 2011 calendar year. figure 1: screen shot of cair link in patient chart immunization registries in the emr era 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 2: screen shot of the patient’s immunization record that is accessed when the link is clicked. survey healthcare providers at lpch were electronically surveyed several months prior to the rollout of the tool with regards to their satisfaction with the prior paper system and their use of the statewide registry (n=41). all lpch residents, general pediatrics attending physicians, primary care clinic nurses and nursing assistants were invited to participate. the providers were again asked to participate in a follow-up survey 4 months after the rollout (n=41). a brief, 7-item survey, including multiple-choice and free-response questions, was developed to assess the provider’s use of cair, perceived impact on their workflow, and satisfaction with the hospital’s immunization recording systems (appendix). r for mac (the r foundation for statistical computing, vienna, austria) was used to perform fisher’s exact test for categorical variables, and the wilcoxon rank sum test to compare the distribution of satisfaction ratings. this project and study were done as part of quality improvement measures and thus irb approval was not required. results figure 3 exemplifies that use of this tool has increased incrementally during the first 4 months following implementation. data from lpch was uploaded to the cair database starting in december 2011—sharing all previously ordered immunizations and any immunizations ordered immunization registries in the emr era 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi using cpoe after that date. over 20,000 new immunization records—both historic and recent— were successfully inserted into the cair database since initiation. forty-one independent providers responded to each of the preand post-surveys as seen in table 1. there was a slight statistical difference of the demographic distribution, as more attending physicians participated in the post-survey. responders indicated increased usage of the registry following interface implementation (p = < 0.001). of the providers surveyed, the majority had never accessed cair prior to the availability of the link. afterwards, the number of providers who had accessed cair significantly increased (p = < 0.001). although, the majority of our respondents were physicians, the primary care clinic nursing staff reported the most frequent use of the tool. overall provider satisfaction increased slightly (p = 0.009), however, the majority of providers (56%) perceived that the smart link improved their efficiency (figure 4). 68% of the surveyed providers felt that the smart link increased the likelihood that their patients’ immunization record was up to date (figure 5). table 1. respondents of preand post-intervention surveys immunization registries in the emr era 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 3: usage of cair link since introduction figures 4: post-intervention survey responses 0 50 100 150 200 250 300 350 400 jan '12 feb '12 mar '12 apr '12 usage of cair link since introduction # click throughs the new emr interface makes it more likely that my patients' immunization information is up to date. agree or strongly agree neutral disagree or strongly disagree immunization registries in the emr era 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figures 5: post-intervention survey responses. discussion few published examples of bidirectional interfaces between emrs and immunization registries exist, and to the authors’ knowledge, none about visual integration within a vendor emr. 17, 18 the hitech act lays out objectives in order to promote emrs and their meaningful use in 3 successive stages. in order to receive economic incentives, each stage of criteria must be met, including those related to electronic data sharing with iis. 5, 6, 11, 19 while unidirectional interoperability is all that is required under hitech, visual integration of the registry is a significant enhancement because institutional immunization data is not only shared with the registry, individual patient data is easily accessible by providers within their workflow. 11 these data suggest that use of cair among providers at lpch has increased since the introduction of the interface to the emr and a significant increase in the link utilization in the months since implementation is shown. an iis is only as robust as the information it receives and the amount it is utilized. 20 the cdc hopes to have >95% of children under 6 included in an iis by the year 2020, 21 a goal that will require participation of many additional institutions. given the parallel federal incentives to implement emr systems, many institutions are similarly hesitant to participate in an iis due to concerns about extra work for staff. 22, 23 the interface implemented at lpch is a web-based link, which preserves the sanctity of the registry database while improving provider workflow. system maintenance is relatively minimal once the algorithms are established. this link was established in a vendor-based system, which could be utilized by many other institutions. the only previously reported of bidirectional interface in nyc was with two smaller emrs, both internally developed. 17, 18 providers at lpch indicated that having the link increased the likelihood that their patients’ immunization information was up to date, as well as their overall efficiency. having my patients' immunization information accessible through the smart link has improved my efficiency agree or strongly agree neutral disagree or strongly disagree immunization registries in the emr era 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi although this study has a relatively small sample size, the authors feel that the responses reflect the general consensus of primary care providers at lpch. despite the slight difference in the demographics of the preand postsurvey groups, it is unlikely that these differences bias the main outcome measures of this study. another limitation is that the outpatient clinics at lpch have not yet started utilizing cpoe to order immunizations, so the data shared with the iis is currently limited to hospitalized inpatients, including newborns in the well baby nursery and obstetric patients. however, given that the link allows access to the entire registry’s data set and not just patients who have had immunizations documented at lpch, its integrated nature makes it useful for providers (both inpatient and outpatient), who are able to examine records from patients’ seen at other area clinics. conclusions the successful implementation of a unidirectional interface between a commercial emr and the california state immunization registry with visually integrated universal access has resulted in significant enhancement in the comprehensive nature of patient immunization records at this hospital. it is the authors’ hope that this example will serve to inspire other institutions with vendor-based emr systems to implement similar interfaces for the good of all communities and patients. acknowledgements the authors would like to acknowledge joshua faulkenberry, pragati kamath, and nestor llerena at lpch, as well as eric dansby, sarah kang, and jagadesh talluri at cair, for their technical expertise and assistance with this project. christopher stave’s assistance with the literature search is also greatly appreciated, as is lisa chamberlain’s inspiration and advocacy leadership. funding: none financial disclosure: the authors have no financial relationships relevant to this article to disclose. conflict of interest: the authors have no conflicts of interest relevant to this article to disclose. author contribution statements: dr. stevens helped conceptualize the project, administered the surveys, analyzed the data, drafted the manuscript, and approved the final version for submission. dr. palma contributed to the statistical analysis, reviewed the manuscript, and approved the submission version. ms. pandher helped design and worked with the technical development of the system, as well as aided in data acquisition and final approval of the manuscript. immunization registries in the emr era 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi dr. longhurst contributed substantially to the conception, design, acquisition of data, analysis, and interpretation of data; revising the article for important intellectual content; and final approval of the published version. corresponding author lindsay stevens, md department of pediatrics 770 welch road, suite 100 palo alto, ca 94304 lindsay.stevens@stanford.edu 650-497-8000 references [1] abramson j. s., o'shea t. m., ratledge d. l., lawless m. r., givner l. b. development of a vaccine tracking system to improve the rate of age-appropriate primary immunization in children of lower socioeconomic status. j pediatr. 1995;126(4):583-586. [2] linkins r. w. immunization registries: progress and challenges in reaching the 2010 national objective. j public health manag pract. 2001;7(6):67-74. [3] placzek h., madoff l. c. the use of immunization registry-based data in vaccine effectiveness studies. vaccine. 2011;29(3):399-411. [4] weinberg st. immunization registries: where we’ve been and where we’re headed. aap news. 2010;31(12):28. [5] meaningful use and immunization information systems. in. [6] meaningful use of electronic health records ehrs. in: american academy of pediatrics. [7] mahon b. e., shea k. m., dougherty n. n., loughlin a. m. implications for registry-based vaccine effectiveness studies from an evaluation of an immunization registry: a crosssectional study. bmc public health. 2008;8(160):160. [8] hinman a. r., ross d. a. immunization registries can be building blocks for national health information systems. health aff (millwood).29(4):676-682. [9] centers for disease control and prevention immunization registry support branch, national immunization program, centers for disease control and prevention. national immunization program. implementation guide for immunization data transactions using version 2.3.1 of the health level seven (hl7) standard protocol, version 2.2. in; 2006. [10] spooner s. a. special requirements of electronic health record systems in pediatrics. pediatrics. 2007;119(3):631-637. [11] dombkowski k. j., clark s. j. redefining meaningful use: achieving interoperability with immunization registries. am j prev med. 2012;42(4):e33-35. [12] palma jp vaneaton eg, longhurst ca. neonatal informatics: information technology to support handoffs in neonatal care. neoreviews. 2011;12(10):e560-e563. [13] bernstein j imler d, sharek p, longhurst c. improved physician workflow and satisfaction after integration of sign-out notes into the emr. joint commission journal of quality and patient safety. 2010. [14] frankovich j longhurst ca, sutherland sm. evidence-based medicine in the emr era. n engl j med. 2011;365(19):1758-1759. immunization registries in the emr era 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [15] longhurst ca parast l, sandborg ci, widen e, sullivan j, hahn js, dawes cg, sharek pj. decrease in hospital-wide mortality associated with implementation of a comprehensive electronic medical record. pediatrics. 2010;126(1):14-21. [16] adams es longhurst ca, pageler n, widen e, franzon d, cornfield dn. computerized physician order entry with decision support decreases blood transfusions in hospitalized children. pediatrics. 2011;127(5):1112-1119. [17] arzt nh. service-oriented architecture in public health: interoperability case studies. journal of healthcare information management. 2010;24(2):45-52. [18] arzt nh forney k, chi a, suralik m, schaeffer p, aponte a. meaningful use and public health: an immunization information system case study. journal of healthcare information management. 2011;25(4):37-44. [19] blumenthal d. launching hitech. n engl j med. 2009;362(5):382-385. [20] davidson a. j., melinkovich p., beaty b. l., chandramouli v., hambidge s. j., phibbs s. l., et al. immunization registry accuracy: improvement with progressive clinical application. am j prev med. 2003;24(3):276-280. [21] progress in immunization information systems united states, 2010. mmwr morb mortal wkly rep. 2012;61(25):464-467. [22] kairys s. w., gubernick r. s., millican a., adams w. g. using a registry to improve immunization delivery. pediatr ann. 2006;35(7):500-506. [23] saville a. w., albright k., nowels c., barnard j., daley m. f., stokley s., et al. getting under the hood: exploring issues that affect provider-based recall using an immunization information system. acad pediatr. 2011;11(1):44-49. immunization registries in the emr era 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi appendix – survey questions pre-survey 1. what is your current position? 2. how often do you need to access immunization information about a patient? 3. have you ever accessed the california immunization registry? the questions below used the likert scale strongly disagree to strongly agree (1-5): 4. i am satisfied with the current system of recording immunizations. 5. i feel that integrating the centralized immunization record into our electronic medical record will improve my workflow. 6. using a centralized resource for immunization records will improve patient care. 7. do you have any additional comments? post-survey 1. what is your current position? 2. how often do you need to access immunization information about a patient? 3. did you ever access the california immunization registry before the link in cerner was available? 4. have you ever accessed the california immunization registry using the link in cerner? 5. if so, how many times have you accessed it in the last 2 weeks? 6. how strongly do you agree or disagree with the following statements? i am satisfied with the current system of recording immunizations. having my patients' immunization information accessible through the smart link has improved my efficiency. the new emr interface makes it more likely that my patients' immunization information is up to date. 7. do you have any additional comments? layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts tau-leaped particle learning jarad niemi*1 and michael ludkovski2 1iowa state university, ames, ia, usa; 2university of california, santa barbara, santa barbara, ca, usa objective develop fast sequential bayesian inference for disease outbreak counts. introduction development of effective policy interventions to stem disease outbreaks requires knowledge of the current state of affairs, e.g. how many individuals are currently infected, a strain’s virulence, etc, as well as our uncertainty of these values. a bayesian inferential approach provides this information, but at a computational expense. we develop a sequential bayesian approach based on an epidemiological compartment model and noisy count observations of the transitions between compartments. methods for simplicity, consider an sir epidemiological compartment model where compartments exist for susceptible, infected, and recovered individuals. transitions between compartments occur in discrete time with transitions numbers given by poisson random variables, the tau-leaping approximation, whose means depend on the current compartment occupancy and some unknown fixed parameters, e.g. virulence. binomial observations, with possible unknown sampling proportion, are made on these transitions. the standard sequential bayesian updating methodology is sequential monte carlo (smc), a.k.a. particle filtering. the original bootstrap filter is effective when the system has no fixed parameters, but exhibits marked degeneracy otherwise [1]. an approach based on resampling the fixed parameters from a kernel density estimate provides a generic approach with less degeneracy [2]. we build methodology based on a particle learning framework [3]. in this framework, each particle carries a set of parameter-specific sufficient statistics and samples parameter values whenever necessary. in addition, the methodology promotes a resample-move approach based on the predictive likelihood that reduces degeneracy in the first place. an improvement on the particle learning framework in this model is that some fixed parameters can be integrated out of the predictive likelihood. this rao-blackwellization provides an smc methodology with reduced monte carlo variance. results for a fixed number of particles or computational expense, we show improvements in accuracy relative to the kernel density approach and an alternative approach based on sufficient statistics [4] where compared with a gold-standard markov chain monte carlo analysis. conclusions many surveillance systems collect counts of adverse events related to some disease. these counts are expected to be a fraction of the true underlying disease extent. the methodology developed here allows a fully bayesian analysis that uncovers the true number of infected individuals as well as disease virulence based on these count data. this statistical approach can be combined with an optimal policy map to help public health officials react effectively to initial disease reports. keywords surveillance; bayesian; sequential monte carlo; particle learning references [1] gordon, salmond, and smith. novel approach to nonlinear/nongaussian bayesian state estimation. iee proceedings part f: communications, radar and signal processing. 140(2): 107-113 (1993). [2] liu and west. combined parameter and state estimation in simulation-based filtering. doucet, de freitas, and gordon, ed. sequential monte carlo methods in practice. springer-verlag, new york. 197— 217 (2001). [3] carvalho, johannes, lopes, and polson. particle learning and smoothing. statistical science. 25(1): 88—106 (2010). [4] storvik. particle filters in state space models with the presence of unknown static parameters. ieee transactions on signal processing. 50(2): 281—289 (2002). *jarad niemi e-mail: niemi@iastate.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e8, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts malaria trends in six outpatient sites in uganda, 2008— 2011 ruth k. nassali*1, arthur mpimbaza1, stella kakeeto1, asadu sserwanga1, fred kizito1, denis rubahika2, melody miles3, michelle chang3, grant dorsey4 and moses kamya1 1infectious diseases research collaboration, kampala, uganda; 2national malaria control program, kampala, uganda; 3centers for disease control, atlanta, ga, usa; 4univeristy of california, san francisco, san francisco, ca, usa objective to estimate trends in malaria morbidity at six sentinel sites in uganda. introduction over the past five years, efforts to control malaria have been intensified in uganda (1). with the intensification of these efforts, accurate and timely data are needed to monitor impact of the interventions and guide malaria control program planning (2, 3). we present data on trends in malaria burden over four years from six outpatient health facilities located in regions of varying malaria endemicity in uganda. methods the study utilized data from the on-going malaria sentinel surveillance program involving six level iv outpatient health facilities: aduku, nagongera, walukuba, kasambya, kihihi and kamwezi. major malaria control interventions between 2008 and 2010 in subcounties where these sites are located included indoor residual spraying (irs) conducted in aduku; insecticide-treated nets (itns) distributed in nagongera and kamwezi. there has been no major control intervention(s) in sub-counties where walukuba, kasambya and kihihi are located. treatment with artemisinin-combination therapies have however been deployed nationally. patient information; demographics, malaria test results and diagnosis are recorded on a standardized patient record. the test positivity rate (tpr) defined as the number of persons testing positive for malaria divided by the total number of persons tested was calculated by year from 2008 to 2011 for two age categories (< 5 years and > 5 years ). results a total of 560,586 patients were seen, of which 25% were <5 years. over 325,500 patients were suspected to have malaria, with the proportion of these having a confirmatory test done increasing from 62% in 2008 to 98% in 2011. between 2008 and 2011, the proportion of the <5 years testing positive for malaria significantly decreased from 66% to 34% in aduku, from 61% to 41% in nagongera, and from 54% to 24% in kamwezi. however, significant increases were seen in kasambya and kihihi from 41% to 51% and from 28% to 44% respectively. the tpr at walukuba remained stable (41% to 45%). similar trends were seen in the > 5 years. conclusions sentinel site surveillance has been a reliable and timely method/tool for monitoring trends in malaria morbidity thereby informing and guiding the uganda malaria control program. keywords surveillance; malaria; trends acknowledgments acknowledgements to nmcp team/moh, cdc/pmi, umsp team, health facility staff. references 1) yeka a, gasasira a, mpimbaza a, achan j, et al. malaria in uganda: challenges to control on the long road to elimination: i. epidemiology and current control efforts. acta trop. 2012 mar;121(3):184-95. epub 2011 mar 21 2) breman jg, holloway cn. malaria surveillance counts. am j trop med hyg 2007;77:36-47 3) bryce j, roungou jb, nguyen-dinh p, naimoli jf and breman jg. evaluation of national malaria control programmes in africa. bull world health organ 1994;72:371-81 *ruth k. nassali e-mail: ruth.nassali@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e81, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts disease mapping with spatially uncertain data justin manjourides*1, ted cohen2, 3, caroline jeffery4 and marcello pagano5 1dept of health sciences, northeastern university, boston, ma, usa; 2div of global health equity, brigham & women’s hospital, boston, ma, usa; 3dept of epidemiology, harvard school of public health, boston, ma, usa; 4intl health group, liverpool school of tropical medicine, liverpool, united kingdom; 5dept of biostatistics, harvard school of public health, boston, ma, usa objective uncertainty regarding the location of disease acquisition, as well as selective identification of cases, may bias maps of risk. we propose an extension to a distance-based mapping method (dbm) that incorporates weighted locations to adjust for these biases. we demonstrate this method by mapping potential drug-resistant tuberculosis (drtb) transmission hotspots using programmatic data collected in lima, peru. introduction uncertainty introduced by the selective identification of cases must be recognized and corrected for in order to accurately map the distribution of risk. consider the problem of identifying geographic areas with increased risk of drtb. most countries with a high tb burden only offer drug sensitivity testing (dst) to those cases at highest risk for drug-resistance. as a result, the spatial distribution of confirmed drtb cases under-represents the actual number of drug-resistant cases[1]. also, using the locations of confirmed drtb cases to identify regions of increased risk of drug-resistance may bias results towards areas of increased testing. since testing is neither done on all incident cases nor on a representative sample of cases, current mapping methods do not allow standard inference from programmatic data about potential locations of drtb transmission. methods we extend a dbm method [2] to adjust for this uncertainty. to map the spatial variation of the risk of a disease, such as drtb, in a setting where the available data consist of a non-random sample of cases and controls, we weight each address in our study by the probability that the individual at that address is a case (or would test positive for drtb in this setting). once all locations are assigned weights, a prespecified number of these locations (from previously published country-wide surveillance estimates) will be sampled, based on these weights, defining our cases. we assign these sampled cases to drtb status, calculate our dbm, repeat this random selection and create a consensus map[3]. results following [2], we select reassignment weights by the inverse probability of each untested case receiving dst at their given location. these weights preferentially reassign untested cases located in regions of reduced testing, reflecting an assumption that in areas where testing is common, individuals most at risk are tested. fig. 1 shows two risk maps created by this weighted dbm, one on the unadjusted data (fig.1, l) and one using the informative weights (fig. 1, r). this figure shows the difference, and potentially the improvement, made when information related to the missingness mechanism, which introduces spatial uncertainty, is incorporated into the analysis. conclusions the weighted dbm has the potential to analyze spatial data more accurately, when there is uncertainty regarding the locations of cases. using a weighted dbm in combination with programmatic data from a high tb incidence community, we are able to make use of routine data in which a non-random sample of drug resistant cases are detected to estimate the true underlying burden of disease. (l) unweighted dbm of risk of a new tb case that received dst being positive for drtb, compared to all new tb cases that received dst. (r) weighted dbm of the risk of a new tb case that received dst being positive for drtb, based on lab-confirmed drtb cases and ipw selected nondst tb cases, compared to all new tb cases. keywords surveillance; multiple addresses; distance based references [1] h lin, et al. assessing spatiotemporal patterns of multidrug-resistant and drug-sensitive tuberculosis in a south american setting. epi infect, 2010. [2] c jeffery. disease mapping and statistical issues in public health surveillance. phd thesis, harvard university, 2010. [3] j manjourides, et al. identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data. tuberculosis, 92(3), 2012. *justin manjourides e-mail: justin.manjourides@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e18, 2013 ojphi-06-e18.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 180 (page number not for citation purposes) isds 2013 conference abstracts autoregressive integrated moving average (arima) modeling of time series of local telephone triage data for syndromic surveillance micael widerström*1, 2, maria omberg1, martin ferm3, ann-katrine pettersson4, malin rundvik eriksson1, ingela eckerdal4 and johan wiström5, 6 1department of communicable disease control and prevention, jämtland county council, östersund, sweden; 2department of clinical microbiology, unit of clinical research centeröstersund, umeå university, umeå, sweden; 3centre of registers in northern sweden, umeå university, umeå, sweden; 4swedish health care direct 1177, jämtland county council, östersund, sweden; 5department of clinical microbiology, infectious diseases, umeå university, umeå, sweden; 6department of communicable disease control and prevention, västerbotten county council, umeå, sweden � �� �� �� � � �� �� �� � objective �������� � ����� �� � ���� ������ ���������� � ��������� ������ ����������� � �� ��������� ��� ������ ����������� � ������������� �� �� �������� ��� ��� �� ���� ���������������� � ����� ����� ��!"!�� �������� ����� � ���������� � ��������������������# introduction $��������� � ���� �� ���������� � ���� ��������� �� ����� ��� ��� ��� ��� ���� ����� ��������� ��� ������ ��������� � ����� ����� � ������ ��� �� ���� ��%�&�#�'����������������� � �������� ��� (��� � � � � �������� �� �� ���� ���������� ���� � ����������#�) ���� ��� ��� �� ��������������� � ���� ������ � ���� ������������� ��� ��� �� ���� � � � �� �������� ��*� �� �� � ���� ��� ���� ������ ����������� �� ��������������� ��� ������������� � ������� � �� ��������������� � ����� �� ������ ������ ���������� ����+ � ����������� �� �� �,--./ ,-%%��0�#�1� � �(�������������� ������ ��� ���������� �� ���� (� ������� �� ��� (����� ���������� ��� ����������� � ���� ������ ���������� ����������������� �������������� �� ������ ������������ � �# methods ) �������� ��� ��������� � ���� ������ �������+ �� ��1 ����� 2�� �3�� ���%%..������ �� �������$�� �� ��,--.����3 � �� ��,-%,� ��� ����������������� ����45�������2�����(�+ � �(� � ������ ����� � ���������� �� �� ���� ���� ����������� ��� ���6!7������ �� ���������� � �� ������ �� ��������� ������ ������8������ �9���� 8��� �������������9������!""��8� � �9�����8�����9�#�3��������� � � � ���� �� ������ ��� � ��� �� �6����������� ����� ������� ������� ���� ����������������������� ���� �� �������� �� � ����-#,-%&�-:� %,������;<< #�����= ��#����#�+ � ������������ ������� � � � � � � ��� ��������� > �!�����������2��� �������!2�������� ���� �� � �������� � � � ������ ��� ����� ��� *��� �� ������7+��#�?�� �� ����� ������� ����������� ���� � � � �����@-a�����@:a(�� � ���� ��(� ���� � �� ������ � ��� � ����� #�?�� ������� ������� ����������� �� ��� � � � �����@-a�����@:a(�� � ���� ��(����� � �� ������ � ��� � ����� # results b� � � ������6!7����� �� �� �������� �������� ������ ����� ��������� ����� ������������!"!����� � ���� ����� � �� �� ������� ������� � ��� ������ �������������!"!����.����c���������� �������� �� �,-%,/,-%&������ � ���������������� � � ��# conclusions ���� � ������6!7����� ��� ����������� � ���� ������ ������� � � �� ����������!"!������ ��� ����� ������ ���=����������� ���� ��� ��� ����������� #�b�� ���� �� ����� ���������� ����� �������������� ����� ���� ����������� ������ � � � � ��� ���� ���� !"!� ��� ���� � ����� � � �������������� �� #�b�� ������������������� ���������� � �������� ����� � ���� �� � �� ����� ������� ����� ����� ������� �������# keywords +��������� ��� ������ d������ ���� � �����d�3��������� � d�3� � � ����� ��d�'������1 �����+��� ������ acknowledgments b�� � ���� � � ���� �� ��� �� � + �� �� 2����� 2������ ��� � �� ���� �7+e�# references %#�3��� � �����(�2��� ��3(�+������(�� ������(�2��� �����f(�g ����� �� $(� �� ��#� ����������� ��� ��������� ��� ������ � �� �� ��� $�������� 1 �����+ ���� �3�� ���� ��� ������h������������)�� #�77)6� 7����7������)����6 �#�,--:�����,id:0�+����;%%.�,,# ,#�+�����+(���������4(�7���������2(�7�����3(�1���� � ��2�j�4(�"��� � +(� ����#�g��� ���� ��������� ��� ������ ����������������������� �� � ����� ������ ����� ���������� ����2����� ���������� ����� ���� $���������� ��� (� ?��� �� k������(� 4�� � �� 4���� ,--c#� ����� +��� � ���#%:�&&�;%@i0 �l���)k(�b �� �k+(������ ��(�k� ������k(�k���������7(�'��� ��6(� �� ��#�b � ���� ������ � ���� ����������� � �������������� � ����� ����� #� '"�+��� #�,--@d0�0�; :,i-# 0#���� � ���b(�e= ������'(�1������(�"�����4(�+� ������+(�)�� � ����� 7#�+��������� ��� ������ ���������������� ���� � ����������� �� � � ;� ��������������� ��� ����� �������� ��� ��� �� ���� ����� � ���� � ����� (� ���� ��*� �� ������� ���� ������ ����������� �� #����� � �����!�� ��#�,-%&�7���%:;%�%%# *micael widerström e-mail: micael.widerstrom@jll.se� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e18, 2014 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts open source health intelligence (oshint) for foodborne illness event characterization catherine ordun, jane w. blake*, nathanael rosidi, vahan grigoryan, christopher reffett, sadia aslam, anastasia gentilcore, marek cyran, matthew shelton and juergen klenk booz allen hamilton, mclean, va, usa objective we propose a cloud-based open source health intelligence (oshint) system that uses open source media outlets, such as twitter and rss feeds, to automatically characterize foodborne illness events in real-time. oshint also forecasts response requirements, through predictive models, to allow more efficient use of resources, personnel, and countermeasures in biological event response. introduction an increasing amount of global discourse reporting has migrated to the online space, in the form of publicly accessible social media outlets, blogs, wikis, and news feeds. social media also presents publicly available and highly accessible information about individual, real-time activity that can be leveraged to detect, monitor, and more efficiently respond to biological events. methods salmonella and escherichia coli (e. coli) events were selected based on the magnitude and number of reported outbreaks to the centers for disease control (cdc) in the last ten years (1). these events affect multiple states and were large enough to ensure appropriate confidence levels when developing response metrics obtained from our prediction models. we collected social media data between 2006 – 2012 due to the emergence of twitter, facebook, and other social media utilization during this time period. characterization is defined as the process of identifying specific event features that inform overall situational awareness. the number hospitalized, dead, or injured, in addition to patient demographics and symptoms were determined to be useful for our characterization and forecast event metrics. analytical methods, such as term-frequency-inverse document frequency (tf-idf), natural language processing (nlp), and information extraction, were used to characterize events according to our metrics. lexicon development, during nlp implementation, was generated from online news articles used to describe the events. lastly, forecasting algorithms were developed to predict the potential response based on similar historical events that were initially characterized by our information extraction algorithms. results the oshint system was developed in amazon web services and includes real-time social media collection for event characterization (see figure 1). oshint currently characterizes number of victims ill, hospitalized, and dead due to foodborne illness events. oshint was used to characterize the recent national 2012 salmonella event related to cantaloupes, during which oshint characterized social media posts related to the event, as news articles and twitter tweets streamed into the system (figure 2). on august 17, 2012 the oshint system identified a large increase in twitter tweets mentioning salmonella. social media data found absent (victims missing work or school day), death, hospital, and sick events to involve 2, 4, 17, 283 media mentions, respectively. our tf-idf algorithm characterized the salmonella event impact as two dead and 150 sickened by salmonella-tainted cantaloupe. retrospective analysis of cdc reported data on august 30, 2012 indicated the salmonella event involved two deaths in 204 cases (2). conclusions the oshint team is continually developing and refining characterization and forecasting algorithms used in the system. upon completion, oshint will characterize symptoms, geography, and demographics for e. coli and salmonella events. the system will also forecast number sick, dead, and hospitalized for an effective and quick response. we will refine our algorithms and evaluate the system against past and future events to provide confidence in our results. figure 1. oshint system in amazon web services. figure 2: 2012 salmonella outbreak in cantaloupe keywords open source; forecasting; social media; response; food safety acknowledgments frederika conrey, kenneth decker, willam lei, dania shor, misha zhurkin references (1) cdc. retrieved september 7, 2012 from http/www.cdc.gov/outbreaknet/investigations. (2) cdc. retrieved august 30, 2012, from http://www.cdc.gov/salmonella/typhimurium-cantaloupe-08-12/index.html. *jane w. blake e-mail: blake_jane@bah.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e128, 2013 development and assessment of a development and assessment of a public health alert delivered through a community health information exchange 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 development and assessment of a public health alert delivered through a community health information exchange roland gamache 1, 3 , kevin c. stevens 2 , rico merriwether 3 , brian e. dixon 3 , shaun grannis 1, 3 1 indiana university school of medicine 2 marion county health department, indiana 3 regenstrief institute abstract timely communication of information to health care providers during a public health event can improve overall response to such events. however, current methods for sending information to providers are inefficient and costly. local health departments have traditionally used labor-intensive, mail-based processes to send public health alerts to the provider community. this article describes a novel approach for delivering public health alerts to providers by leveraging an electronic clinical messaging system within the context of a health information exchange. alerts included notifications related to the 2009 h1n1 flu epidemic, a syphilis outbreak, and local rabies exposure. we describe the process for sending electronic public health alerts and the estimated impact on efficiency and cost effectiveness. keywords: public health alerts, health information exchange, syndromic surveillance, clinical messaging, h1n1 flu, broadcast alert introduction a major challenge for public health is facilitating timely communication of information between public health agencies and health care providers. for example, the underreporting of many public health conditions can make accurate surveillance difficult. [1] conversely, public health professionals find it difficult to let physicians, nurses, and other front line health care workers know that an outbreak may be occurring in their region. a high-priority public health message in the form of an alert is commonly used by public health agencies to share important information with providers.[2] for local health departments, these alerts are typically paper-based, delivered through postal mail, and they target a broad range of health care providers in a specific geographic region (e.g., zip code). although health alert networks (hans) have utilized electronic alerts for several years, hans are often state-run networks that use workflows optimized for non-clinical providers and may reach a limited set of clinical recipients, typically focusing on sentinel physicians. [3, 4] current paper-based alerting processes have inherent constraints that limit their effectiveness. first, it may take 1 to 4 days for a message sent by the united states postal service to reach the development and assessment of a public health alert delivered through a community health information exchange 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 physician and additional time to open the mail. second, the delivery of the mail item is not verified, so it is uncertain if the physician actually receives the message. finally, traditional sources for physician contact information such as state licensing boards may be incomplete or out-of-date. these issues occur in part because physicians may provide a home or other nonclinical address, or may change practice location after license registration. consequently, the physician may never receive the alert, receive a delayed alert, or receive the alert in a location where the information may not impact the clinician’s decision-making (e.g., the following day when he or she is at the clinical practice site). the use of a health information exchange (hie) to deliver public health alerts may help to mitigate these challenges. hie organizations facilitate the sharing of clinical and administrative health care data among health care institutions, providers, and data repositories.[5] an hie is an organized entity, often a legal corporation, that specializes in facilitating electronic exchange of health information among a diverse group of often competing health care system stakeholders, including hospitals, laboratories, and physician practices.[6, 7] a recent survey reported that as many as one-third of community hies may involve data exchange with public health agencies.[8] we hypothesize that public health agencies may more efficiently communicate with health care providers if hie infrastructure is leveraged to deliver public health provider alerts. this hypothesis is supported because a core competency of hies is to assure that clinical information reaches the appropriate provider at the appropriate place and time, and they often ensure the information is received and utilized. transmitting public health alert messages can be managed in a fashion nearly identical to clinical information messages, and their receipt can be verified. finally, electronic public health alerts sent to a provider at their place of practice and incorporated into their routine work processes may increase the likelihood that the information will impact clinical decisions. with 40 years of experience as a medical informatics research organization regenstrief researchers have demonstrated that an hie can be leveraged to support and improve core functions of public health, such as surveillance. [9-11] we have also shown that alerts and reminders incorporated into electronic health record systems can affect clinical decision-making. [12-14] thus, it should be feasible to leverage an hie in a similar fashion to deliver alerts and reminders to broad physician cohorts, beyond the scope of one organization and one electronic health record (ehr) system. this paper describes our initial experiences using an hie to deliver electronic public health alerts to clinicians. we present a novel framework for alerting community physicians about emerging public health threats while incurring minimal changes to clinical workflow, and we illustrate the framework with real-world scenarios in which the local health department utilized the hie. additionally, we discuss draft measures to support evaluating the effectiveness of this framework for public health alert delivery as compared to delivery by current methods. development and assessment of a public health alert delivered through a community health information exchange 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 methods clinical message overview in our context, the term ”clinical messaging” describes the delivery of clinical results to physician offices using one of three transmission methods: a) direct import into an ehr system, b) electronic push to a secure, web-based portal, or c) facsimile (fax) transmission. designed and developed at the regenstrief institute, the docs4docs® (d4d) clinical messaging service is provided by the indiana health information exchange (ihie). the service receives laboratory, transcription, and radiology information from participating data sources (e.g., hospitals, laboratories) via real-time, secure health level 7 (hl7) feeds.[15] d4d converts the computable clinical results into a standardized reporting format that includes a header with the sending organization’s logo and contact information. once converted, the report is delivered to the intended provider. to ensure that all messages are successfully delivered, ihie personnel follow-up on any non-fax message left unopened after 72 hours. the docs4docs® service also delivers electronic copies of discharge summaries, operative notes, and electrocardiograms (ekgs). as of february 18, 2009, there were 3,636 practices with just over 10,000 physicians utilizing the docs4docs® service throughout indiana. of those practices, 2,335 (64 %) received messages via fax, 1,337 (37 %) viewed messages via the webbased inbox, and 52 (one %) accessed their messages from within their ehr system. public health alerting in addition to delivering clinical data, a clinical messaging service can act as an adjunct to existing public health alert network functions.[16] in 2008, the regenstrief institute, indiana university school of medicine, ihie, and the marion county health department (mchd) collaborated to develop a public health alerting interface within the docs4docs® service. the interface allows public health alerts to be delivered in a manner consistent with the physicians’ existing message delivery preferences. messages can be sent to all physicians within a jurisdiction, or messages can be targeted to specific practices based on clinical specialty (e.g., family physician, pediatrician) or geography (e.g., zip code). figure 1 shows a screenshot of an actual alert delivered to a fictitious user’s inbox. development and assessment of a public health alert delivered through a community health information exchange 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 figure 1. physician's screen showing a public health alert sent to a docs4docs® web-based inbox. this alert describes action to be taken for a shigella outbreak. alerting workflow after creating the alert message, the public health agency emails it to the regenstrief institute where personnel, with access to the public health alerting interface, submit the message. the clinical messaging system delivers the public health alert to physicians specified in the alert. the early alerting activity has focused on the indianapolis metropolitan statistical area including marion county. in 2009, the united states census estimated marion county's population at 891,000. as the state capital and indiana's largest city, indianapolis is the 14th largest city in the united states. mchd is one of only two local health departments in indiana to conduct syndromic surveillance[17] with the state and provides a variety of public health services related to population and environmental health. syndromic surveillance to conduct syndromic surveillance, mchd utilizes two systems: the public health emergency surveillance system (phess)[18] and the electronic surveillance system for the early notification of community-based epidemics (essence). both systems are supplied data from 74 indiana hospital emergency departments in real-time and managed by ihie. in monitoring the magnitude of the h1n1 flu outbreak, state and county epidemiologists monitored the count of influenza-like illness (ili) cases. results the public health alert interface within docs4docs® was completed in early 2009. since then, nine public health alerts have been disseminated to physicians in marion county. table 1 development and assessment of a public health alert delivered through a community health information exchange 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 provides a timeline of the various alerts distributed via the docs4docs® service. three of the alerts provided updates regarding the h1n1 outbreak of 2009. the remaining alerts distributed information regarding local outbreaks and updates concerning public health policies. table 1. summary of alerts sent by the health information exchange for the local public health agency date alert sent description of the alert 4/29/09 h1n1 flu alert 5/13/09 h1n1 flu alert (follow-up) 8/26/09 syphilis outbreak alert 9/15/09 h1n1 flu vaccination information 2/17/10 rabies information and treatment update 4/1/10 new vaccination requirements for school 4/15/10 syphilis outbreak reminder on april 29, 2009, mchd sent a h1n1 flu alert to marion county physicians who utilize the docs4docs® service. using their syndromic surveillance system, mchd identified a steep rise in h1n1 chief complaints and influenza testing (figure 2) and wanted to provide physicians with information on how to handle suspected cases. a subsequent h1n1 flu alert was sent on may 13, 2009, when a school closed due to a dramatic rise in h1n1 cases within the county, and a h1n1 flu vaccination information alert was sent on september 15, 2009, informing physicians on how to ensure their practice had vaccines on hand for the impending flu season. figure 2. laboratory testing for h1n1 during the flu season by date development and assessment of a public health alert delivered through a community health information exchange 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 r a ti o o f p o si ti v e t e st s b y t o ta l t e st s date ratio of positive influenza tests ratio of positive tests figure 3. ratio of positive influenza tests by date since january 2009, mchd has reported an outbreak of syphilis in marion county, indiana. a syphilis public health alert was sent on august 26, 2009, to inform physicians of the ongoing outbreak. since the syphilis outbreak was unresolved in early 2010, another public health alert was sent on april 15, 2010. information about treating individuals who may have rabies was sent on february 17, 2010. in addition to public health alerts related to diseases, mchd sent an alert on april 1, 2010 notifying physicians about new school vaccination requirements. there were 3,085 physicians eligible to receive an alert through docs4docs® as of april 29, 2009. of those, docs4docs® successfully processed messages for 3,021 (97.9%) providers. messages to 64 providers were "lost" during the message generation process. this bug was fixed prior to the sending of the second broadcast message. of the 3,021 providers, 158 (5%) of them were returned as undeliverable. in an effort to reduce the laboratory testing burden, on april 30, 2009 the indiana state department of health transmitted an alert (through the state’s han system) providing new guidelines for sample testing of the ”worried well” during the early phases of the h1n1 flu outbreak.[19] data from the hie-based influenza surveillance system points to a decrease in the number of samples tested after the alert was sent (figure 3). this suggests the potential impact of the electronic alerts in changing provider behavior in a short time frame for an issue of large impact on the health of the community. development and assessment of a public health alert delivered through a community health information exchange 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 figure 4. number of requested syphilis tests per week during 2010. on april 15, 2010, mchd sent an alert describing a syphilis outbreak in the community. a review of the hie-based data for the number of syphilis tests ordered during this period did not show a significant increase in the number of tests ordered after the april 15 date. in fact, after the first week the number of tests requested for syphilis showed signs of a decrease. a graph of this data is presented in figure 4. (the horizontal line on the graph represents the average number (1,787) of syphilis tests ordered per week based on the first 23 weeks of 2010.) discussion we developed and implemented an integrated alerting service for public health agencies to communicate more effectively and efficiently with clinicians. our experience suggests that electronic public health alerts, when integrated into existing clinical workflows, have the potential to improve public health practice and clinical decision-making. although assessment of the new service was limited, there are many potential benefits of this kind of service to public health, providers, and hies. value of alerts there are several areas of added value through the process of sending public health alerts through the health information exchange in the community. one such value is improved timeliness: the alert is delivered to the physician the same day that it is sent. with more timely information the clinical delivery system may be more likely to respond to the inciting event and potentially reduce some of the resource burden to the community.[20] if only one organization is maintaining a list of electronic addresses for providers and the list is used by multiple organizations, the total cost for this list maintenance is reduced. there should 0 500 1000 1500 2000 2500 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 number of tests week number number of syphilis tests per week 2010 average number of tests per week follow-up syphilis alert sent development and assessment of a public health alert delivered through a community health information exchange 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 also be an additional added value for the hie in identifying bad addresses earlier in the process and prevent the delay of sending urgent clinical data to the provider in a timely fashion. with enhanced information about the provider, such as practice location and practice specialty, alerts from public health could be targeted to those providers that would most benefit from a community alert. examples of targeted messages could be for outbreaks in a particular geographic location or information targeted to providers that deal in primary care or pediatrics. public health agencies stand to receive several benefits from an automated alerting system through a community hie. first, agencies can improve the speed in which alerts reach clinicians. whereas the united states postal mail can take several days, electronic messages through an hie can be transmitted to clinicians within minutes. second, the messages are received by providers through established work patterns. third, the delivery and receipt of the messages can be monitored to confirm delivery and more quickly identify communication errors. finally, there is a direct cost savings to the public health agency when using an hie compared to a paper-based system. the estimated costs for a public health alert mailing are based on previous public health mailings that occurred in the state over the last several years. the costs for envelops, letterhead, and labels were obtained from our purchasing department. the costs listed are per 100 items to make the amounts easier to read (i.e., no fractional cents are listed). the total amount of labor time to order these materials is based on placing and validating the order. the total time required for placing the labels on the envelops, printing the labels, stuffing envelopes and adding postage is based on prior mailings that averaged approximately twenty hours of total staff time for 2,000 mailed items. the distribution among the categories listed is an estimate, however; the total time is reliable and based on several mailings that occurred over the last several years. the postage cost is a savings based on the united states postal service listing and is a generally used business practice for larger mailings. finally, the indirect rate is an estimate of actual indirect costs (electric, rent, etc.) and not the indirect rate that is negotiated for grants and contracts. all of these numbers are presented so that public health departments can use their own estimates if they wish to calculate an estimated savings from their own experience. the total cost savings for the public health agency in this study was estimated to be $3,638 for each set of alerts sent. this dollar amount was calculated based on sending 3,085 alerts to providers and community. development and assessment of a public health alert delivered through a community health information exchange 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 table 2. potential cost and labor benefits for public health by using electronic alerts a description estimated cost (per 100 letters) cost of letterhead b $16.67 cost of envelopes (pre-printed return address) c $16.13 cost of labels d $2.00 labor cost of supply ordering e, f $6.25 labor cost of printing and affixing labels e, g $8.33 labor cost of stuffing envelopes and adding postage e, h $16.67 postage cost i $41.40 indirect cost j $10.47 estimated savings $117.92 notes a. the cost of writing the alert is not included since the alert would be written and approved for either process b. 1500 sheets/box at $250 per box c. 1500/box at $242 per box d. 1500 labels package at $30 per package e. assume labor and fringe at $25/hr f. estimated at 15 minutes per 100 g. estimated at 20 minutes for printing one hundred labels and affixing labels to envelopes h. estimated labor of 40 minutes for 100 letters i. commercial presorted rate from the united state postal service at $0.414 per letter j. the indirect rate is estimated to be 33.5% on labor costs only improving the speed of delivery of public health alerts and ensuring their integration into clinical workflow increases the likelihood that public health agencies can influence clinical decisionmaking. if providers are able to access timely, actionable information through existing work practices, there is a better chance they will modify standard care in response to the new information. previous research has shown that providers do respond to public health alerts.[2123] for example, a community alert was sent out to providers, which established refined protocols for testing for the h1n1 virus. these testing criteria included specific information about patient symptoms in order to be tested for this virus. the provider community, adjusted the testing criteria, based on these protocols. we observed this same change in behavior when mchd used the docs4docs® system to send an h1n1testing alert to providers. in comparison, surveillance data following the broadcast alert describing an increase in syphilis in the community did not reveal any evidence of change in provider behavior based on a change in the number of tests requested for syphilis following the last broadcast alert. there are several reasonable explanations to be explored in order to fully understand why no effect was seen in this instance. first, the broadcast alert sent out in 2010 was a follow-up reminder from a previous alert sent out in 2009. also, information about the outbreak was provided to the physician community through many professional channels, including other public health agency announcements and communications through supplementary professional channels. therefore, providers may have already changed their behavior and consequently no significant increase in syphilis testing rate would be detected in the physician practice. development and assessment of a public health alert delivered through a community health information exchange 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 additionally, many of the symptoms for syphilis remain undisclosed by the patient or undetectable on physical exam. if a potential syphilis patient presents at a clinic or office with chief complaints for a condition unrelated to a potential syphilis case, the encounter may not trigger a consideration by the physician to order a syphilis test for this individual. in order for providers to better respond to this type of public health alert, a more specific epidemiological profile may be needed to notify the provider community about patients that present at the encounter with chief complaints unrelated to underlying syphilis symptoms. another possible explanation would be if the patient demographics shifted over the period between the two public health alerts, particularly in consideration of the change in the economic climate or other social factors. many of these cases initiate from the county hospital. if there was a change based on the downturn in the economic conditions in the community, there would be an expected increase in patient volume at the county hospital. therefore, there would also be an expected increase in the number of patients screened for syphilis testing. we considered looking at a change in rates for the analysis of this parameter; however, determining the denominator for this analysis was difficult. there is only an average of 1,787 syphilis tests ordered per week and approximately 2.7 million messages over this same period. therefore, the calculated rates would be small and any change hard to measure. once again, a more specific epidemiological profile would help in this analysis as well. it is clear that further study is necessary in order to fully assess and understand the ability of public health broadcast alerts to impact physician behavior.[24] providers also stand to benefit from electronic public health alerts delivered through a community hie. first, providers will see a reduction in the postal mail they receive from public health. second, the information sent from public health will be timelier, potentially improving clinicians’ perception of public health agencies. finally, the information arriving in the alerts will be actionable and provide tailored guidance that clinicians can use to enhance the quality and safety of care they deliver to patients. preliminary conversations with providers in our region reveal that many clinicians welcome this kind of change in how public health communicates with the provider community. the community hie also benefits from this partnership. this activity provides an additional service to a common platform and provides another mechanism for validating and verifying provider addresses in the community. this updated provider information is important when sending out clinical information regarding patients in the provider’s practice. since the infrastructure for delivering clinical health information is being reused for the delivery of broadcast alert messages, total costs for the community are potentially reduced. finally, information concerning the contact lists for physicians is necessary for both public health and the community health information exchange. since this information is collected only once and maintained by one organization, total costs are reduced. the overall community also benefits from this partnership. since information about community outbreaks are provided in an manner that are easily maintained and delivered through a timely mechanism, the disease burden experienced by the community should be reduced. this change development and assessment of a public health alert delivered through a community health information exchange 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 should result in a more effective response to community acquired infections, and therefore a more effective use of healthcare resources. future directions end-user acceptance of this new data sharing mechanism (broadcast messages) will be strongly influenced by end-user perception of the process. consequently, the attitude of physician and public health groups to how these new data sharing mechanisms are perceived will be evaluated. we will also examine if there is a difference of perception or practice by physicians that are primarily paper-based in the office versus those physicians are using a clinical messaging system like docs4docs. each of these outcome measures may be evaluated for a survey tool to gain the perspective of the position and may be measured empirically through information gained in the clinical data repository. we plan to evaluate the perceived utility of these interventions with stakeholders from both public health and clinical health care settings to gage unforeseen complexities and advantages. finally, because general alerts seem to be less effective in producing behavioral changes in the provider practice, future work to identify what types of detailed information included in the public of alert are most likely to produce provider changes is warranted. conclusions the process of providing public health alerts through the community health information exchange provides a cost savings to public health over the traditional system of a mail-based public health alert. more analyses are needed to fully assess the other impacts of this type of delivery system to include provider groups and the health information exchanges. delivering public health alerts to physicians using an existing clinical messaging system represents a well-scoped and incremental step forward that has the potential to improve process efficiency, including reduced costs and improved timeliness. by engaging both clinical stakeholders and public health stakeholders in such a pervasive and ongoing activity, we can continue to build the digital bridge and trust relationships between the two domains that are necessary to establish the infrastructure for the next stage of more complex public health decision support processes. acknowledgements this work was funded by the centers for disease control & prevention under contract 2002008-24368. the content of this publication does not necessarily reflect the views or policies of the department of health and human services, nor does mention of trade names, commercial products, or organizations imply endorsement by the u.s. government. the views expressed in written conference materials or publications and by speakers and moderators at hhs-sponsored conferences, do not necessarily reflect the official policies of the department of health and human services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the u.s. government. development and assessment of a public health alert delivered through a community health information exchange 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 references [1] thacker, s.b. and r.l. berkelman, “public health surveillance in the united states. epidemiology review”, 1988. 10: p. 164– 190. [2] cdc. health alert network. 2010; available from:http://www2a.cdc.gov/han/index.asp. [3] daniel, j.b., et al., connecting health departments and providers: syndromic surveillance's last mile. mmwr morb mortal wkly rep, 2005. 54 suppl: p. 147-50. [4] baker, e.l. and j. porter, the health alert network: partnerships, politics, and preparedness. j public health manag pract, 2005. 11(6): p. 574-6. [5] ahrq. health information exchange. key topics 2009 february [cited 2010 february 7]; available from: http://healthit.ahrq.gov/hie. [6] dixon, b.e., a. zafar, and j.m. overhage, a framework for evaluating the costs, effort, and value of nationwide health information exchange. j am med inform assoc, 2010. 17(3): p. 295301. [7] dixon, b.e. and s. scamurra. is there such a thing as healthy competition? in annual himss conference & exhibition. 2007. new orleans, la: himss. [8] hessler, b.j., et al., assessing the relationship between health information exchanges and public health agencies. j public health manag pract, 2009. 15(5): p. 416-24. [9] overhage, j.m., s. grannis, and c.j. mcdonald, a comparison of the completeness and timeliness of automated electronic laboratory reporting and spontaneous reporting of notifiable conditions. am j public health, 2008. 98(2): p. 344-50. [10] grannis, s., et al., the indiana public health emergency surveillance system: ongoing progress, early findings, and future directions. amia annu symp proc, 2006: p. 304-8. [11] grannis, s.j., et al., how disease surveillance systems can serve as practical building blocks for a health information infrastructure: the indiana experience. amia annu symp proc, 2005: p. 286-90. [12] rosenman, m., et al., computerized reminders for syphilis screening in an urban emergency department. amia annu symp proc, 2003: p. 987. [13] dexter, p.r., et al., a computerized reminder system to increase the use of preventive care for hospitalized patients. n engl j med, 2001. 345(13): p. 965-70. [14] dexter, p.r., et al., effectiveness of computer-generated reminders for increasing discussions about advance directives and completion of advance directive forms. a randomized, controlled trial. ann intern med, 1998. 128(2): p. 102-10. [15] barnes, m., lessons learned from the implementation of clinical messaging systems. amia annu symp proc, 2007: p. 36-40. [16] grannis, s., p.g. biondich, and b.w. mamlin, how disease surveillance systems can serve as practical building blocks for a health information infrastructure: the indiana experience. amia annu symp proc, 2005. [17] grannis, s., et al., the indiana public health emergency surveillance system: ongoing progress early findings and future directions. amia annu symp proc, 2006. [18] gamache, r.e. and m. wade, the indiana public health emergency surveillance system (phess), in ehealth initiative, blueprint award for improving population health. 2007: washington, dc. [19] health, i.s.d.o., indiana epidemiology newsletter, 2009. 17(4). http://www2a.cdc.gov/han/index.asp http://healthit.ahrq.gov/hie development and assessment of a public health alert delivered through a community health information exchange 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 [20] elson, r.b. and d.p. connelly, “computerized patient records in primary care: their role in mediating guidelinedriven physician behavior change. archives of family medicine, 1995. 4: p. 698–705. [21] marc rosenman, m., et al., computerized reminders for syphilis screening in an urban emergency department. amia annu symp proc., 2003. 2003. [22] gamache, r.e., the indiana medical error reporting system, in indiana healthcare executives network. 2006: indianapolis, in. [23] staes, c.j., et al., computerized alerts improve outpatient laboratory monitoring of transplant patients. journal of the american medical informatics association, 2008. 15(3): p. 324-332. [24] the purpose of first syphilis broadcast alerts that were sent through the community hie were to determine the feasibility of the hie to send these types of messages. the measurement of the impact of these messages was clearly a greater priority after the feasibility was demonstrated. the associated attributes for messages sent after the initial messages are clearly more aligned to measure outcome in the provider community. layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a binational model of collaboration for enhancing cross-border id surveillance kristine ortwine*2, 1, karen ferran1 and esmeralda iniguez-stevens1 1early warning infectious disease surveillance, california department of public health, san diego, ca, usa; 2san diego state graduate school of public health, san diego, ca, usa objective the purpose of this demonstration is to describe the cross-border collaborative processes used for the development of a transparent methodology to identify and prioritize zoonotic infectious disease agents in the california-baja california border region. introduction international borders present unique challenges for the surveillance of infectious disease. border communities represent locations with vast differences in cultures and languages, governing institutions, healthcare access, and priorities for the collection and surveillance of disease data. pathogens and the health and security risks they create do not respect geographical and political boundaries. however, the organizations responsible for the surveillance and control of these agents must function within the borders of their respective governments. one border one health (oboh) is a binational, multidisciplinary initiative aimed at engaging partners in the us and mexico to identify and implement methods for successful communication and collaboration to enhance health capacity and disease surveillance within the border region. the advancements of international initiatives such as oboh will help to develop the types of multi-country networks necessary for the effective monitoring of disease patterns and risks. methods one border one health surveillance committee participants represent multi-disciplinary professionals working together for the advancement of one health principles in the california/baja california border region. this showcase documents the identification and prioritization of zoonotic infectious disease agents along the us-mexico border, by use of a transparent methodology which engaged public and private partners from both countries. preliminary research and input from collaborators in government, academic, and private sectors in the us and mexico allowed for review and discussion of current methodologies available for prioritizing infectious agents. the discontools work package 2 prioritization scoring model was selected as the basis for scoring and weighting various zoonotic diseases of concern within border region. subject matter experts were then asked to review and score an initial list of diseases, in order to produce a final ranked list of pathogens. the intent is that these prioritized pathogens will be used by government agencies to make informed decisions, integrating priorities from both nations with regards to infectious disease surveillance. this collaboration provides insight into the binational cooperation needed for the selection of diseases to be considered in a regional, integrated disease surveillance system. to the authors’ knowledge this is the first transparent scientific-based approach to pathogen prioritization in the us-mexico border region. conclusions oboh is the first binational regional network of its kind along the us-mexico border recognizing the interconnectivity between human, animal, and environmental health. given the limited resources in the current economic climate, the use of regional integrated surveillance systems provide an opportunity to protect and improve border health and security by moving away from species-specific surveillance programs. the process showcased here for the transparent review and prioritization of pathogens along the california-baja california border can be used as a model along the entire us-mexico border. the ultimate aim is to protect border communities through the creation of a binational, early warning surveillance system which would allow for actionable and timely interventions to limit emergence, mitigate spread, provide gap analysis, and enhance prevention and control for several emergent and re-emergent diseases. ultimately, this will decrease negative health and environmental impacts while improving agricultural and economic outcomes in both nations. however, obstacles such as continued sustainability, identification of new multidisciplinary collaborators, cooperation between government agencies, and identifying funding for advancement of integrated regional surveillance systems remain challenges. keywords one health; disease surveillance; cross-border collaborative *kristine ortwine e-mail: kristine.ortwine@cdph.ca.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e206, 2013 development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi development of a web gis application for visualizing and analyzing community out of hospital cardiac arrest patterns hugh semple 1 , han qin 1 , comilla sasson 2 1 department of geography and geology, eastern michigan university, ypsilanti, mi, 2 department of emergency medicine, university of colorado at denver, denver, co background each year, almost 300,000 individuals die from out-of-hospital cardiac arrest (ohca) in the united states (roger et al., 2011). sasson et al. (2010) pointed out that the survival rate for ohca varied between 6.7% and 8.4%, a statistic that had largely remained relatively stagnant for over thirty years. geographically, nichol et al. (2008) have shown that survival rates from out-of-hospital cardiac arrest vary tremendously by city in the us. for example, the survival to discharge rate in seattle in 2008 was estimated at 8.1% while in dallas, it was only 2.4% (nichol et al., 2008). given the wide geographic variability in ohca survival rates, a major task is identifying communities that have high risk for ohca and targeting them for cpr education abstract improving survival rates at the neighborhood level is increasingly seen as a priority for reducing overall rates of out-of-hospital cardiac arrest (ohca) in the united states. since wide disparities exist in ohca rates at the neighborhood level, it is important for public health officials and residents to be able to quickly locate neighborhoods where people are at elevated risk for cardiac arrest and to target these areas for educational outreach and other mitigation strategies. this paper describes an ohca web mapping application that was developed to provide users with interactive maps and data for them to quickly visualize and analyze the geographic pattern of cardiac arrest rates, bystander cpr rates, and survival rates at the neighborhood level in different u.s. cities. the data comes from the cares registry and is provided over a period spanning several years so users can visualize trends in neighborhood out-of-hospital cardiac arrest patterns. users can also visualize areas that are statistical hot and cold spots for cardiac arrest and compare ohca and bystander cpr rates in the hot and cold spots. although not designed as a public participation gis (ppgis), this application seeks to provide a forum around which data and maps about local patterns of ohca can be shared, analyzed and discussed with a view of empowering local communities to take action to address the high rates of ohca in their vicinity. correspondence: hsemple@emich.edu copyright ©2013 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi outreach, priority placement of automated external defibrillators (aeds), and other intervention activities, as a means to help to improve overall survival rates in these communities. the purpose of this paper is to report on an ongoing project to develop a user-friendly, interactive web mapping application that allows epidemiologists, policy makers, program managers, and the general public to quickly understand the geographic pattern of cardiac arrest rates, bystander cpr rates, and survival rates at the neighborhood level in selected u.s. cities. the selected cities are all cities in which the cardiac arrest registry to enhance survival (cares) has operations. cares is a registry established in 2004 by the centers for disease control (cdc) and the department of emergency medicine at the emory university school of medicine to monitor ohca events in the us (mcnally et al., 2009). the goal of the web mapping application is to provide map-based information and raw data to health care professionals, policy makers, and members of the public to enable them to visualize and analyze the ohca situation at the neighborhood level, and, where necessary, to take actions to address the high rates of ohca in certain neighborhoods. in the following sections of this paper, we outline the application development process and the usability design considerations employed in building the web mapping application. we also describe the application itself as well as user evaluations of the website. method the application development process to develop the ohca web application, we followed, to a large extent, the five-stage usercentered design model put forward by kinzie et al., (2002). the kinzie et al., model was used to design a web application to assist patients in recording and maintaining their family health histories. these histories can be used by both patients and physicians to identify potential health problems, and by physicians for preventive or treatment recommendations (kinzie et al., 2002). the five stages of application development set forth in the model are: (1) identification and assessment of client and users’ needs, (2) goal/task analysis (3) initial prototype design, (4) evaluations and refining of prototypes and final stage application, and (5) project implementation and maintenance. the client for our project was a researcher working with the cares group (https://mycares.net/). in stage one of application development, several meetings were held with the client to develop a clear picture of the conceptual requirements of the application from the client’s perspective. within these meetings, the goal of the application, a stage two requirement of the model, was clarified. the main goal of the application was stated as: to provide interactive web maps and data to public health professionals, policy makers, and members of the public to help them to visualize and analyze the geographic pattern of out-of-hospital cardiac arrest rates, bystander cpr rates, and survival rates at the neighborhood level in different u.s. cities. stage three of the application development process called for the development of an initial prototype. we used the documented goal of the research, the client’s requirements of the development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi application’s functionalities, and our own background research about similar type applications to design the initial prototype. in stage four of the application development, we used several rounds of semi-formal evaluations to incorporate user perspective into the unpolished prototype designs. participants in these evaluations were graduate students with knowledge of cartography, programming and gis, and members of the general public. convenience sampling was used to select the evaluators. although the average sample size was 10 persons, the small sample size was considered more than sufficient as the usability evaluation literature points out that after the first five or six interviews, about 75 percent of the fatal design errors and problems will be identified (nielsen 1994, krug 2006, shneiderman and plaisant 2006). open-ended questions via email were the main technique used to solicit feedback from evaluators. users were directed to the project’s website and asked to carry out various tasks using the application. they were then requested to comment on the degree of success carrying out the tasks, their satisfaction level, userfriendliness, and quality of output. feedbacks from these semi-formal evaluations were used to update the prototype leading to a more improved product. indeed, user feedback in stage four of the application development process helped us to considerably improve the design of the application each time the survey was completed. for example, users suggested that hyperlinks should be created to provide access to technical discussions on the topics portrayed on the maps. comments were made about legend design, color choice, the quality of dynamic labeling, interface layout, and the functioning of various tools. after each survey, we addressed users’ concerns by incorporating their suggestions into the application. a more expanded user evaluation was done at the beta release of application development, when all the software functionalities were completed. this final beta evaluation will be described later in the paper. incorporating usability design considerations into the ohca web application given that many of the users of the application were not expected to be experts in gis, we were particularly interested in incorporating state-of-the art usability ideas in the design of the ohca web application. in web mapping application development, usability issues surfaced as important considerations since the early part of the last decade as researchers sought to create interactive web mapping applications that met user needs and expectations (maceachren and kraak 2001, maceachren 1995). usability problems associated with interactive web mapping applications include: poor user interface design (e.g., too small map area; legend too large, incompatible colors information overload, and poor layout (arleth 1999). users unable to understand map tools or map tools being too difficult to use (harrower et al., 2000). motivated users not interpreting the published maps in intended ways (ishikawa et al., 2005). unreadable or badly placed text; poor visualization of search results; lack of useful help or guidance to use the software (nivala et al., 2008). development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi user-centered design is recognized by many researchers as the best means of avoiding the design problems mentioned above. user-centered design is essentially a product development methodology that incorporates the views of users at all stages of the product development cycle in order to create a product that meets users' needs. the methodology forces designers to consider both the objectives of the design and the needs and preferences of users within the context of existing technology (norman 2002). while many cartographers have discussed usability issues in web mapping design, a few have concentrated on the usefulness of web mapping applications, arguing that applications should not only be easy to use, but that they should also serve useful ends (fuhrmann et al., 2005). norman (2005), the well-known usability researcher, has argued that focusing too much on usability often leads to the development of “cool” applications that fail to help people accomplish needed tasks. he called for designers to place emphasis on functionalities that meet the goal of the web application because these activity-centered designs are better placed than usability designs to deliver tools that effectively support users in real-world contexts. in this project, we sought to achieve both ‘usability’ and ‘usefulness’ in web map design by working closely with both the client and the intended users of the application to incorporate their feedback into the project at every stage in the design process. we relied on the agile approach to software development to guide this process. this approach to software development is one that emphasizes consultations with the client at each of several iterations in the project cycle (abrahamsson et al., 2010, ambler 2002). feedbacks from these consultations are immediately incorporated into the design process, thus the final product greatly reflects user concerns. in addition to utilizing ideas from the agile approach to software development, we incorporated the traditional geovisualization concept of presenting multiple views of the same data into the application design (maceachren and kraak 2001). our application provides downloadable cartographic representations of the data based on user-constructed queries. raw data in the form of shapefiles and attribute data are also provided. advanced user of the application can use these raw datasets to analyze and create their own representations of the ohca problem in the various neighborhoods. in later versions of the application, we intend to include capabilities that would allow users with meaningful local knowledge of the ohca problem to upload data to the web application and share the details of their differing perspectives with other users of the application. recently, the web gis design literature, taking its cue from developments in e-commerce, has begun discussing issues related to how the general public and expert gis users develop trust in interactive mapping websites sufficient to enable them to confidently interact with the application’s data and analytical output (skarlatidou et al., 2011). to improve the trustworthiness of web gis applications, skarlatidou and her colleagues point out that the responsibility is on the person or organization supplying the web gis application, the trustee, to establish the necessary trust attributes. according to the authors, there are two main types of trustee attributes which must be developed to foster increased trusts in web applications, perceptual attributes and functional attributes. perceptual trustee attributes deal with the trustee’s honesty, integrity and reliability. functional attributes, on the other hand, deal with the application features, e.g. aesthetics and usability features that increase the trustworthiness of the application. development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi in designing our web application, we implemented both perceptual and functional trustee attributes. for example, we used trust cues such as the logo of the cardiac arrest agency that promotes strategies to reduce the rates of ohca at the neighborhood level. we also included feedback mechanisms in the form of easy access to social media pages on discus, facebook and twitter to enable users to comment on the validity of the official data that was presented. two other trust cues we provided were information to contact the designers of the application, and hyperlinks to published online reports that supported the cardiac arrest patterns displayed on our maps. with respect to functional trustee attributes, we relied on addressing the usability concerns mentioned earlier, e.g., improved interface design, attention to color use, dynamic labeling, reliance on multiple views of the data, ensuring correctness of data, and correctness of algorithms and queries used to produce end-user maps, etc. results the ohca web mapping application the ohca web mapping application developed for the project can be viewed at http://geodata.acad.emich.edu/ohca. figure 1 shows the graphical user interface (gui) of the application with a census tract level ohca rates map for the city of columbus, ohio being displayed. in this project, census tracts were used as proxies for neighborhoods. the title of the application, “cares out of hospital cardiac arrest (ohca) web mapping application”, a perceptual trust attribute, is prominently displayed at the top left of web page. towards the top right of the application, an additional trust cue, the cares logo, is prominently displayed and hyperlinked to the cares website. links to the project home page is also highly visible. a link to information to contact the designers of the application, which is another perceptual trust attribute, is placed at the top right of the page. towards the top left of the user interface, a brief note informs the user about the purpose of the application and provides a general idea of how to start using it. below this note, drop down boxes allow users to select parameters to build queries. users select a city of interest, the period for which they want to display data, and the type of map desired, e.g., ohca rates map, bystander cpr map, survival rates map, etc. once the submit button is clicked, users can generate maps that show ohca rates, bystander cpr rates, etc., at the census tract level for the city. http://geodata.acad.emich.edu/ohca development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 1: the ohca web mapping application showing ohca neighborhood rates for columbus, ohio, 2004 whenever the map for a particular city is displayed, the application automatically produces a histogram below the map showing the rates distribution for whatever is being mapped. this is part of the multi-view approach to presenting the data. in addition to the histogram, summary statistics are displayed to the lower left of the screen. the attribute table associated with the map layer is also displayed allowing the user to peruse the actual data used to create the map. if desired, users can download the attribute table in excel, txt, or pdf formats. each row in the attribute table is hyperlinked to the related feature on the map allowing users to explore locational aspects of the neighborhood. users can explore the geography of census tracts by accessing an aerial imagery layer supplied by the national agriculture imagery program (naip). the application also allows for each location on a thematic layer to be viewed directly in google map. a set of navigation tools are provided at the top of the screen. access to social-media software to foster discussion about local patterns of ohca is placed right alongside the navigation tools for high visibility. to the lower right of the screen are the legend and an overview map to help users locate themselves in the us if they are zoomed into to a particular neighborhood. the application was built using mapserver, a popular open source platform for creating interactive web mapping applications (http://mapserver.org/). the default user interface for a basic mapserver application is created using only html and css. this means that development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi functionalities such as panning, zooming, querying, etc., are implemented in simple, often inelegant ways. we used the p.mapper framework to add dynamism to the static html user interface. for example, the p.mapper framework allowed us to add a customizable navigation toolbar for panning and zooming the map, returning to previous or full extent, etc. the toolbar also contains functions for identifying map features and their attributes through point and click, and for selecting features through the use of select boxes. p.mapper also facilitated the use of a slider to alternatively zoom the map. user-specified attribute queries of the map were implemented by writing several php and javascript functions to perform the queries. the ohca application displays the following types of maps at the neighborhood level: ohca rates, bystander cpr rates, percent in-home cardiac arrest rates, and hot and cold spots. the rates were calculated outside of the application using arcgis, and geoda, an open source spatial statistics software. rates were smoothed using geoda’s routines for spatial empirical bayesian rates. for the hot and cold spot maps, hot spots (i.e., high-risk census tracts) were defined as census tracts having a higher than expected ohca incidence risks and lower than expected incidence risks of bystander cpr over a period of two consecutive years. alternatively, cold spots (i.e., low risk census tracts) were defined as those having a lower than expected ohca incidence risks and higher than expected incidence risks of bystander cpr over a period of two consecutive years. the actual spatial analysis to identify the ohca hot and cold spots was done outside the web application using geoda and arcgis software. the technical details of this process have been described in (semple et al., 2012). essentially, for any given year, local moran’s i was used to separately identify clusters of ohca rates and bystander cpr rates. the two sets of hotspots were then overlaid on each other to identify the tracts that had both high rates of ohca and low rates of bystander cpr rates for that year. because hotspots can be temporally unstable, we overlaid hotspots of one year on top of hotspots for the preceding year to identify what we called “persistent” clusters of high-risk communities. utilizing trustworthiness interface design ideas, a hyperlink to the online paper describing how the maps were created was supplied. also, to aid user interpretation of the maps, a note is provided on the screen when the maps display to indicate how to interpret the maps. final user-evaluation in this section, we describe and present results of the user evaluation that was conducted on the beta application. at this stage, we wanted to make a final determination as to whether users were able to use the application to carry out specific tasks with ease. we also wanted to carry out a usability assessment of the application, as measured on the system usability scale (sus)(brooke 1996). although the sus is a quick and easy way to conduct a usability assessment, its reliability has been confirmed by many writers (bangor et al., 2008). using the work of brooke (1996) as a guide, the goals of the final evaluation were defined as follows: (1) to determine the ability of users to easily complete tasks for which the application was designed; (2) test the level of difficulty required to complete tasks; and (3) to determine whether the output of tasks were satisfactory to users. eleven persons were purposefully selected to participate in the evaluation. the sample reflected potential users of the application and consisted of both technical gis users as well as members of development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi the general public without previous gis experience. the url of the application was again emailed to the evaluators along with login information to survey monkey, an online questionnaire survey site that hosted the questionnaire. a formal questionnaire was developed for this evaluation (appendix 1). evaluators were asked to perform specific tasks using the web application and then respond to a set of close and open-ended questions about the layout of the application, ease of use of tools, problems encountered, and the severity of the problems. responses to the close-ended questions were measured on a 5-point likert scale ranging from “strongly disagree (1)” to “strongly agree” (5). evaluators were also requested to fill out the questions on the systems usability scale (appendix 1). following bangor et al., (2008), we used a slightly modified version of brooke (1996) system usability scale. for the modified version, bangor et al. (2008) suggested that the word “cumbersome” in question 8 be changed to “awkward” to read “i found the system very awkward to use”. also, on three occasions, the word “system” was changed to “product” for greater clarity. the response rate to the survey was 70%. this was considered to be good since the response rate for many web surveys is around 30-40% even with populations that have easy access to the web (archer 2008). in terms of the overall ability of users to easily complete the seven tasks they were given, 67% agreed that they were able to complete all of them (table 1). the two tasks that gave users the most difficulties were task 3 – “ determine the ohca rates for census tracts in worthington, a community in columbus, ohio” and task 4 – “determine the three communities in columbus, ohio that had the highest rates of ohca”. only 44% of respondents strongly agreed that these tasks were easy to complete (table 1). evidently, the steps for performing these tasks were not intuitive. we subsequently addressed these issues by providing explanations on the help page. as to the questions about whether users were pleased with the output of the various tasks, only 36% strongly agreed, while 36% agreed (table 2). users did not like the quality of the output maps, particularly the quality of feature labeling and the placement of certain map elements. also, while users were able to easily generate hot and cold spots from the application, they could not easily interpret the meaning of hot and cold spots. users also complained that the fields in the attribute table should be formatted at each query to reflect only fields of information pertinent to the query and not display the entire set of fields in the table. these issues have since been addressed. responses to questions about user interface are shown in table 3. most users agreed that the application had a user-friendly interface and that the navigation tools and other control were easy to use. in terms of response to the individual sus questions, the average sus score from the respondents was 72.2, with a standard deviation of 6.23. following bangor et al. (2009), this score converts to an overall b when translated to a letter score. according to bangor and his colleagues, the average sus score is 68, so our sus score of 72.2 indicates that most users had a fairly positive experience using our web application. altogether, the values indicated to us that the participants felt that the web mapping application was a useful, user-friendly geovisualization tool, but additional work was needed to enhance output quality. development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi table 1. results for ease of accomplishing tasks on the web application was task easy to accomplish? strongly agree agree neutral disagree strongly disagree task 1. create a neighborhood rates map of ohca rates in columbus, ohio for 2004. 83% 17% task 2. create a map showing percent "in-home" ohca arrests by neighborhoods for columbus, ohio for the range of years, 2004 2006. 83% 17% task 3. determine the ohca rates for census tracts in worthington, a neighborhood in columbus, ohio. 33% 33% 33% task 4. determine the three neighborhoods in columbus, ohio that had the highest rates of ohca. 33% 33% 16.7% 17% task 5. display maps of high-risk and low-risk areas for ohca in columbus for 2008. 83% 17% task 6. print a map of the neighborhood ohca rates for columbus, ohio for 2006. 67% 33% task 7. download a csv file of ohca rates for different communities in columbus and open the file in excel. 83% 17% development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi table 2. results for “i was pleased with the map output of the ohca rates map” was task easy to accomplish? strongly agree agree neutral disagree strongly disagree task 1. create a neighborhood map of ohca rates for columbus, ohio 2004. 33% 67% task 2. create a map showing percent "in-home" ohca arrests by neighborhoods for columbus, ohio for the range of years, 2004 2006. 50% 50% task 3. determine the ohca rates for census tracts in worthington, a neighborhood in columbus, ohio. 17% 33% 50% task 4. determine the three neighborhoods in columbus, ohio that had the highest rates of ohca. 33% 33% 17% 17% task 5. display maps of high-risk and low-risk areas for ohca in columbus for 2008. 20% 40% 20% 20% task 6. print a map of the neighborhood ohca rates for columbus, ohio for 2006. 33% 17% 33% 17% task 7. download a csv file of ohca rates for different communities in columbus and open the file in excel. 67% 17% 17% development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi table 3. results for user interface evaluation responses strongly agree agree neutral disagree strongly disagree the ohca mapping application has a user-friendly user interface. 16.70% 83% i was able to easily use the map navigation tools. 66% 33% i was able to easily use the zoomin/zoom-out tools. 83% 17% i was able to easily use the "select tool". 67% 33% i am comfortable with the color schemes used for the maps and legends. 33% 67% i was able to easily query the map using the "sql" tool. 67% 33% kindly click on the “go to google” button and investigate how this tool works. this tool was helpful in excel. 33% 33% 33% for people who know how to use gis software, we are allowing them to download our data to create their own maps of neighborhood out of hospital cardiac arrest patterns. this was a good idea. yes: 83% no: 17% discussion in creating the ohca web mapping application, we sought to depart from an application development model in which designers believe that they knew exactly what the users needed or wanted. we wanted to incorporate ideas from the web mapping usability literature to create an application that would allow users to effectively interact with the map information and quickly come to an understanding of the geographic distribution of ohca events in their city and the risk of the event in their own neighborhood. while it is still too early to assess whether the goal of the web mapping application was achieved, a number of issues emerged from this project that may be of interest to others engaged in the development of similar type applications. first, it was remarkable the amount of feedback information obtained from the intermediate evaluations as well as from the final beta evaluation. members of the general public and experts in the field of cartography, programming and gis contributed significant insights into the design development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi of the application and the usefulness of certain functionalities. for example, some users wanted to be able to click on the points that showed the location of cares cities around the country and be taken to the main query window. there were also requests for the histogram that appears as part of map queries to be made interactive. users wanted the bars in the histogram to be linked to the specific map features, so that selection of a bar would result in the selection of the map feature associated with the bar, as well as the record in the attribute table. several noted that the names of fields in the attribute tables were unclear and that the application needed to provide more information about cardiac arrest victims, e.g. average age, race, gender, etc. from a cartography perspective, comments were made about the need for greater clarity in the legend text and better coordination in color choice. some users pointed out that the dynamic text placement of mapserver was not properly managed and resulted in clutter at certain zoom levels. these users called for greater finesse in labeling map features at all zoom levels. although we were not able to incorporate all users requests into our design, we are strongly convinced that designing from a user-centered perspective is a superior way of designing web mapping software compared to one in which the major design elements are left entirely to the software developer or to a team of developers. secondly, we are convinced that displaying data across multiple views (map, tabular, chart, summary statistics, and raw data) is a superior way of presenting cartographic data compared to a style of presenting only one view. we believe that this presentation style addresses the needs of different types of users. for example, those with only a need to view available maps and summary statistics can simply view these products online. others with the need to do their own analysis on the data can download the data and analyze it using their own techniques and thus create their own view of the geography of ohca events. thirdly, despite the fact that web maps allow us to easily understand geographic disease patterns, a review of web sites dedicated to discussing public health issues reveal that these sites are generally not designed as a forum around which local health issues can be discussed. most use a tabular or interactive map presentation paradigm and do not provide tools at the website to foster discussions about the tabular or geographic patterns inherent in the data and their health significance to local communities. such discussions often occur elsewhere in social media websites. during the course of this project, we began exploring the idea of building a web application that links tabular data provision and interactive geovisualization with social networking and social bookmarking tools to allow users to discuss, at the particular website, the significance of different disease patterns from a local community perspective. our attempts to do so in this project has been simply to create twitter, discuss and facebook pages and link these to buttons from within the web application so that users can easily access the online forums where the local ohca patterns are being discussed. in future versions of this application, we hope to add a volunteered geographic data component to allow users to supplement the official data presented on the website with local, user-generated data. this is an idea already present in the public participation literature, but combining these capabilities within a container that facilitates discussion using social media software can yield significant benefits. development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi conclusion the application development process described in this paper allowed us to focus specifically on what ohca researchers and potential users of the web mapping application felt were important to them in a web mapping application created to disseminate ohca information and data. the application was built based on detailed analysis of client and user needs and careful selection of available technology based on cost considerations and software capabilities. incorporating stateof-the art usability concepts into the application design was also an important consideration. although this first version of the application is effective in supplying a wide range of maps and datasets to aid in the identifying of high-risk areas for ohca events at the neighborhood level, we feel that there is scope for enhancement of the application in many areas. in later versions of the software, we will increase the interactivity between histograms and the maps, allow for greater integration of multimedia in the design and generally expand the paradigm of building a public health web mapping application that is centered around interactive maps, summary statistics, use of social media technology to discuss patterns inherent on the map, and the ability of users to add local information to the map to supplement and add richness to the official data used to create the basemaps. corresponding author hugh semple professor, department of geography and geology eastern michigan university ypsilanti, mi email: hsemple@emich.edu references [1] abrahamsson p, oza n, siponen mt. agile software development methods: a comparative review. in: dingsøyr t, dybå t, moe nb, eds. agile software development. berlin, heidelberg: springer berlin heidelberg; 2010:31–59. available at: http://link.springer.com/chapter/10.1007/978-3-642-12575-1_3?null. accessed september 11, 2012. [2] ambler s. agile modeling effective practices for extreme programming and the unified process. john wiley & sons, inc; 2002. [3] archer tm. response rates to expect from web-based surveys and what to do about it. journal of extension., 2008; 46 (3). accessed on september 22, 2012. http://www.joe.org/joe/2008june/rb3.php. [4] arleth m., problems in screen map design. proceedings of the 19th international cartographic conference, ottawa, canada, 1999; 1, 849-857. [5] bangor a., kortum pt, & miller jt. "an empirical evaluation of the system usability scale". international journal of human-computer interaction, 2008; 24(6): 574–594. [6] bangor a., kortum pt, & miller jt. "determining what individual sus scores mean: adding an adjective rating scale". journal of usability studies, 2009; (3): 114–123. [7] brooke j. "sus: a "quick and dirty" usability scale". in p. w. jordan, b. thomas, b. a. weerdmeester, & a. l. mcclelland. usability evaluation in industry. london: taylor and francis, 1996. http://link.springer.com/chapter/10.1007/978-3-642-12575-1_3?null http://www.joe.org/joe/2008june/rb3.php development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [8] fuhrmann, s., ahonen-rainio, p., edsall, r.m., fabrikant, s.i., koua, e.l.,tobón, c., ware, c., and wilson, s. making useful and useable geovisualization: design and evaluation issues, in: exploring geovisualization, ed. by dykes, j., maceachren, a., kraak, m.-j. (elsevier, oxford), 2005. [9] harrower m, maceachren a, griffin al. developing a geographic visualization tool to support earth science learning. cartography and geographic information science. 2000; 27(4):279. [10] ishikawa t., barnston ag., kastens ka, louchouarn p, ropelewski, cf., 2005. climate forecast maps as a communication decision-support tool: an empirical test with prospective policy makers. cartography and geographic information science, 32, 3-16. [11] kinzie mb, cohn wf, julian mf, knaus wa. a user-centered model for web site design. j am med inform assoc. 2002;9(4):320–330. [12] krug s. don’t make me think! a common sense approach to web usability. new riders publishing company, berkeley, california, 2006. [13] maceachren am. & kraak mj. research challenges in geovisualization. cartography and geographic information science. 2001; 28(1): 3. [14] maceachren am. how maps work: representation, visualization, and design. new york: guilford press; 1995. [15] mcnally b, stokes a, crouch a, kellermann al; cares: cardiac arrest registry to enhance survival. cares surveillance group. ann emerg med. 2009 nov;54(5):674683.e2. [16] nichol g, thomas e, callaway cw, et al. regional variation in out-of-hospital cardiac arrest incidence and outcome. jama: the journal of the american medical association. 2008; 300(12):1423–1431. [17] nielsen j. usability engineering. boston: ap professional; 1994. [18] nivala am, brewster s, sarjakoski t. usability evaluation of web mapping sites. the cartographic journal. 2008; 45(2): 129-138. [19] norman da. human-centered design considered harmful. interactions. 2005;12(4):14. [20] norman da. the design of everyday things. basic books; 2002. [21] roger vl, go as, lloyd-jones dm, et al. heart disease and stroke statistics—2011 update a report from the american heart association. circulation. 2011. available at: http://circ.ahajournals.org/content/early/2010/12/15/cir.0b013e3182009701. accessed september 11, 2012. [22] sasson c, rogers ma, dahl j, kellermann al. predictors of survival from out-of-hospital cardiac arrest a systematic review and meta-analysis. circ cardiovasc qual outcomes. 2010;3(1):63–81. [23] semple h, cudnik m, sayre m, keseg d, warden c, sasson c. identification of high risk communities for unattended out of hospital cardiac arrest using gis. journal of community health, 2012, doi: 10.1007/s10900-012-9611-7. [24] skarlatidou a, haklay m & cheng t. trust in web gis: the role of the trustee attributes in the design of trustworthy web gis applications, international journal of geographical information science, 2011. doi:10.1080/13658816.2011.557379. [25] shneiderman b, plaisant c. strategies for evaluating information visualization tools: multidimensional in-depth long-term case studies. in: proceedings of the 2006 avi workshop on beyond time and errors: novel evaluation methods for information visualization. beliv ’06. http://circ.ahajournals.org/content/early/2010/12/15/cir.0b013e3182009701 http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s10900-012-9611-7#_blank http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s10900-012-9611-7#_blank development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi new york, ny, usa: acm; 2006:1–7. available at: http://doi.acm.org/10.1145/1168149.1168158. accessed september 11, 2012. appendix 1 please use the ohca web mapping application (http://geodata.acad.emich.edu/ohca) to carry out the tasks below and then report your satisfaction level for each task. task 1 create a map showing neighborhood ohca rates for columbus, ohio for 2004. 1. the above task was easy to accomplish. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 2. i was pleased with the map output of the ohca rates map. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 3. if you were displeased with the ohca rates map, what were you displeased with? _________________________________________________________________ task 2 create a map showing percent "in-home" ohca arrests by neighborhoods for columbus, ohio for the range of years, 2004 2006. 4. the task describe above was easy to accomplish. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 5. i was pleased with the "in-home" ohca arrests map by neighborhoods for columbus, ohio, 2004-2006. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 6. if you were displeased with the "in-home" ohca rates map, what were you displeased with? ______________________________________________________________________ task 3 determine the ohca rates for census tracts in worthington, a neighborhood in columbus, ohio. 7. the task described above was easy to accomplish. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 8. i was pleased with the map and table output of the above task. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 9. if you were displeased with the worthington rates map, what were you displeased with? http://doi.acm.org/10.1145/1168149.1168158 development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi ___________________________________________________________________ task 4 determine the three neighborhoods in columbus, ohio that had the highest rates of ohca. 10. the task described above was easy to accomplish. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 11. i was pleased with the rates information i obtained from the above task. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 12. if you were displeased with the rates information you obtained, what were you displeased with? _____________________________________________________________________ task 5 display maps of high-risk and low-risk areas for ohca in columbus for 2008. 13. the task described above was easy to accomplish. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 14. i was pleased with the map output of the above task. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 15. if you were displeased with the hot or cold spot maps what were you displeased with? ______________________________________________________________________ task 6. print a map of the neighborhood ohca rates for columbus, ohio for 2006. 16. the task described above was easy to accomplish. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 17. i was pleased with the appearance of the map. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 18. if you were displeased with the appearance of the printed map, what specifically were you displeased with? ____________________________________________________________________ task 7 download a csv file of ohca rates for different communities in columbus and open the file in excel. 19. the task described above was easy to accomplish. development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 20. i was pleased with the format of the data i downloaded. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 21. if you were displeased with the csv file you downloaded, what specifically were you displeased with? ___________________________________________________ user-interface evaluation 22. the ohca mapping application has a user friendly user interface. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 23. i was able to easily use the map navigation tools. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 24. i was able to easily use the zoom-in/zoom-out tools. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 25 i was able to easily use the "select tool". (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 26. i am comfortable with the color schemes used for the maps and legends. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 27. i was able to easily query the map using the "sql" tool. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 28. kindly click on the “go to google” button and investigate how this tool works. this tool was helpful (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 29. for people who know how to use gis software, we are allowing them to download our data to create their own maps of neighborhood out of hospital cardiac arrest patterns. this was a good ideas. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree development of a web gis application for visualizing and analyzing community out-of-hospital cardiac arrest patterns 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi overall system usability evaluation 1. i think that i would like to use this system frequently. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 2. i found the system unnecessarily complex. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 3. i thought the system was easy to use. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 4. i think that i would need the support of a technical person to be able to use this system. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 5. i found the various functions in this system were well integrated. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 6. i thought there was too much inconsistency in this system. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 7. i would imagine that most people would learn to use this system very quickly (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 8. i found the system very cumbersome to use. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 9. i felt very confident using the system. (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree 10. i needed to learn a lot of things before i could get going with this system (1) strongly disagree (2) disagree (3) neutral (4) agree (5) strongly agree isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts first detection of salmonella spp. in backyard production farms from central chile raul alegria-moran*1, 2, 3, andres lazo1, dacil rivera4, viviana toledo4, andrea moreno-switt5 and christopher hamilton-west1, 3 1department of preventive veterinary medicine, faculty of veterinary and animal science, universidad de chile, santiago, chile; 2phd program in agriculture, forestry and veterinary science, universidad de chile, santiago, chile; 3emerging and reemerging zoonoses research network, santiago, chile; 4universidad nacional andres bello, santiago, chile; 5center of veterinary medicine, universidad nacional andres bello, santiago, chile objective the purpose of this study was to detect the presence of circulating salmonella spp. on backyard production systems (bps) with poultry or swine breeding in central chile introduction characteristics and conditions of backyard production systems (bps) transform them into potential maintainers of priority zoonotic agents, like salmonella spp., highly important agent because of its impact in animal and public health (1). methods a stratified and proportional random sampling approach was performed (2), based on 15 provinces from the study area (regions of valparaiso, metropolitana and lgb o’higgins). 329 bps sampled (equivalent to 1,744 samples). stool content inoculated in test tubes with peptone water (apt, difco®) supplemented with novobiocin (sigma®), incubated for 18 to 24 hours at 37° c. subcultured on modify semisolid rappaport vassiliadis (msrv, oxoid®) agar supplemented with novobiocin, incubated for 24 to 48 hours at 41.5° c. samples compatible with growth and/or diffusion were sub-cultured by exhaustion on xylose lysine deoxychocolate (xld, difco®) agar and then incubated for 24 hours at 37° c (3). confirmation made by conventional pcr for inva genes (4). serotypes were predicted using a combination of pcr and sequencing, aimed directly at genes coding for o, h1 and h2 antigens (5). results 1,744 samples were collected belonging to the 329 bps. 15 positive bps (4.6%) detected. serotypes detected correspond to salmonella typhimurium (21.7%), followed by salmonella enteritidis (13.0%) and salmonella infantis (13.0%), salmonella hadar or istanbul (8.7%), salmonella [z42] or tenessee (4.4%), salmonella kentucky (4.4) and unknown (34.8%) (table 1). conclusions this is the first evidence of serotypes of salmonella spp. circulating at a regional level in bps from central chile. a relevant pathogen for public health. table 1. characterization of salmonella spp. circulating in bps from central chile ?? = unkonwn keywords salmonella spp.; backyard production systems; one health; backyard surveillance acknowledgments founded by fondecyt 11121389 to chw and conicyt 21130159 to ra-m. references 1. iqbal, m. 2009. controlling avian influenza infections: the challenge of the backyard poultry. journal of molecular and genetic medicine, 3, 119–120. 2. dohoo, r., martin, w. & stryhn, h. 2010. veterinary epidemiologic research, second edition. ver inc., prince edward island, canada. 3. marier, e. a., snow, l. c., floyd, t., mclaren, i. m., bianchini, j., cook, a. j. c., davies, r. h. 2014. abattoir based survey of salmonella in finishing pigs in the united kingdom 2006–2007. preventive veterinary medicine, 117, 542-553. 4. malorny, b., hoofar, j., bunge, c., helmuth, r. 2003. multicenter validation of the analytical accuracy of salmonella pcr: towards an international standard. applied and environmental microbiology, 69, 290-296. 5. ranieri, m. l., shi, c., moreno-switt, a. i., den bakker, h. c., wiedmann, m. 2013. comparison of typing methods with a new procedure based on sequence characterization for salmonella serovar prediction. journal of clinical microbiology, 51, 1786-1797. *raul alegria-moran e-mail: ralegria@veterinaria.uchile.cl online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e154, 2017 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts content analysis of tobacco-related twitter posts mark myslín*, shu-hong zhu and michael conway uc san diego, san diego, ca, usa objective we present results of a content analysis of tobacco-related twitter posts (tweets), focusing on tweets referencing e-cigarettes and hookah. introduction vast amounts of free, real-time, localizable twitter data offer new possibilities for public health workers to identify trends and attitudes that more traditional surveillance methods may not capture, particularly in emerging areas of public health concern where reliable statistical evidence is not readily accessible. existing applications include tracking public informedness during disease outbreaks [1]. twitter-based surveillance is particularly suited to new challenges in tobacco control. hookah and e-cigarettes have surged in popularity, yet regulation and public information remain sparse, despite controversial health effects [2,3]. ubiquitous online marketing of these products and their popularity among new and younger users make twitter a key resource for tobacco surveillance. methods we collected 7,300 tobacco-related twitter posts at 15-day intervals from december 2011 to july 2012, using ten general keywords such as cig* and hookah. each tweet was manually classified using a tri-axial scheme, capturing genre (firsthand experience, joke, news, …), theme (underage usage, health, social image, …), and sentiment (positive, negative, neutral). machine-learning classifiers were trained to detect tobacco-related vs. irrelevant tweets as well as each of the above categories, using naïve bayes, k-nearest neighbors, and support vector machine algorithms. finally, phi correlation coefficients were computed between each of the categories to discover emergent patterns. results the most prevalent genre of tweets was personal experience, followed by categories such as opinion, marketing, and news. the most common themes were hookah, cessation, and social image, and sentiment toward tobacco was more positive (26%) than negative (20%). the most highly correlated categories were social image–underage, marketing–e-cigs, and personal experience–positive sentiment. e-cigarettes were also correlated with positive sentiment and new users (even excluding marketing posts), while hookah was highly correlated with positive sentiment, pleasure, and social relationships. further, tweets matching the term “hookah” reflected the most positive sentiment, and “tobacco” the most negative (figure 1). finally, negative sentiment correlated most highly with social image, disgust, and non-experiential categories such as opinion and information. the best machine classification performance for tobacco vs. nontobacco tweets was achieved by an svm classifier with 82% accuracy (baseline 57%). individual categories showed similar improvements over baseline. conclusions several novel findings speak to the unique insights of twitter surveillance. sentiment toward tobacco among twitter users is more positive than negative, affirming twitter’s value in understanding positive sentiment. negative sentiment is equally useful: for example, observed high correlations between negative sentiment and social image, but not health, may usefully inform outreach strategies. twitter surveillance further reveals opportunities for education: positive sentiment toward the term “hookah” but negative sentiment toward “tobacco” suggests a disconnect in users’ perceptions of hookah’s health effects. finally, machine classification of tobacco-related posts shows a promising edge over strictly keyword-based approaches, allowing for automated tobacco surveillance applications. sentiment in “hookah” tweets is disproportionately more positive than in “cig” and especially “tobacco” tweets. keywords social media; surveillance; twitter; tobacco; nlp references [1] chew, c. & eysenbach, g. pandemics in the age of twitter: content analysis of tweets during the 2009 h1n1 outbreak. plos one. 2010; 5(11):e14118. [2] ayers, j. w., ribisl, k. m., & brownstein, j. s. tracking the rise in popularity of electronic nicotine delivery systems (electronic cigarettes) using search query surveillance. am j prev med. 2011; 40(4):448–453. [3] grekin, e. r. & ayna, d. waterpipe smoking among college students in the united states: a review of the literature. j am coll health. 2012; 60(3):244–249. *mark myslín e-mail: mmyslin@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e66, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts use of control bar matrix for outbreak detection in syndromic surveillance system tao tao1, qi zhao1, huijian cheng2, lars palm3, xin lu4, 5, hui yuan2, xiaoxiao song1 and biao xu*1 1school of public health, fudan university, shanghai, china; 2jiangxi provincial center for disease control and prevention, nanchang, china; 3future position x, gävle, sweden; 4division of global health (ihcar), department of public health sciences, karolinska institutet, stockholm, sweden; 5college of information systems and management, national university of defense technology, changsha, china objective to develop and test the method of incorporating different control bars for outbreak detection in syndromic surveillance system. introduction aberration detection methods are essential for analyzing and interpreting large quantity of nonspecific real-time data collected in syndromic surveillance system. however, the challenge lies in distinguishing true outbreak signals from a large amount of false alarm (1). the joint use of surveillance algorithms might be helpful to guide the decision making towards uncertain warning signals. methods a syndromic surveillance project (issc) has been implemented in rural jiangxi province of china since august 2011. doctors in the healthcare surveillance units of issc used an internet-based electronic system to collect information of daily outpatients, which included 10 infectious related symptoms. from issc database, we extracted data of fever patients reported from one township hospital in gz town between august 1st and december 31st, 2011 to conduct an exploratory study. six different control bar algorithms, which included shewart, moving average (ma), exponentially weighted moving average (ewma) and ears’ c1, c2, c3, were prospectively run among historical time series of daily fever count to simulate a real-time outbreak detection. each control bar used 7 days’ moving baseline with a lag of 2 days [the baseline for predicting day(t) starts from day(t-9) to day(t-3), c1 method used a lag of zero day]. we set the threshold of µ+2! for shewart and ma, and 2.1 for ewma c1, c2 and c3. an alarm was triggered when the observed data exceeded threshold, and the detailed information of each patient were checked for signal verification. microsoft excel 2007 was used to calculate the simulation results. results during the 5 months, gz township hospital reported 514 outpatients with fever symptom, with an average of 3.4 per day. all control bars were simultaneously operated among daily counts of fever cases. of the 153 days on surveillance, 29 triggered alarms by at least one of the control bars. nine days triggered alarms from >= 3 control bars while on one day (12/30) all 6 algorithms raised alarms. figure 1 shows the date, fever count, algorithm and warning level (color) of each alarm, which we called a control bar matrix. it can be seen that c3 and ewma present a higher sensitiveness towards tiny data change whereas c1, c2 and ma focus on large increase of data. c3 also had a memory effect on recent alarms. no infectious disease epidemic or outbreak event was confirmed within the signals. most fever patients on the nine high-warning days (red and purple) were diagnosed as upper level respiratory infection. however, we discovered that the sharp increase of fever cases on 12/30 was attributed to 5 duplicate records mistakenly input by the staff in gz hospital. conclusions by combining control bars with different characteristics, the matrix has potential ability to improve the specificity of detection while maintaining a certain degree of sensitivity. with alarms categorized into hierarchical warning levels, public health staffs can decide which alarm to investigate according to the required sensitivity of surveillance system and their own capacity of signal verification. though we did not find any outbreak event in the study, the possibility of localized influenza epidemic on high-warning days cannot be wiped out, and the matrix’s ability to detect abnormal data change was apparent. the proper combination, baseline and threshold of control bars will be further explored in the real-time surveillance situation of issc. figure 1: detailed information of alarm signals generated by control bar matrix (no-alarm days were omitted). keywords syndromic surveillance; matrix; control bar; signal acknowledgments this study was funded by [european union’s] [european atomic energy community’s] seventh framework programme ([fp7/2007-2013] [fp7/2007-2011]) under grant agreement no. [241900]. references 1. fearnley l: signals come and go: syndromic surveillance and styles of biosecurity. environment and planning a 2008, 40(7):1615-1632. *biao xu e-mail: bxu@shmu.edu.cn online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e111, 2013 editorial: ojphi vol 3, no 2 (2011) 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 editorial: ojphi vol 3, no 2 (2011) the current issue of ojphi contains eight refereed articles and a working paper. while these articles came from independent sources, they represent a common theme—the use of information science and communication technologies to advance the fields of public health practice and healthcare in general. they cover articles that use xforms standards to demonstrate bidirectional communication between provider and public health systems, explore the migration of hand-held health records from paper-based systems to electronic formats to track health risks in developing countries, utilize agent based models to study the spread of infectious diseases within communities, explore crowdinforming as a process control strategy to balance patient loads among emergency departments, analyze the use of food safety informatics as a technological tool to protect consumers in real time against foodborne illnesses, demonstrate the efficacy of the use of telemedicine to remotely supervise newly graduated general dentists in rural india, identify the factors that facilitate the adoption web-based health portals for health statistics dissemination in indonesia, and explore patient-centric modifications to the electronic medical records architecture. early detection of risks to the community such as outbreaks of infectious or foodborne diseases depend on the timely reporting of notifiable conditions to public health agencies by health care providers, laboratories, and others mandated to carry our such notifications. notifiable condition reporting and alerting are two important public health functions. the recent hitech act of 2009 emphasizes interoperability between provider systems and public health systems. in a paper entitled “applying the xforms standard to public health case reporting and alerting,” rebecca a hills et al. used xforms standards and nationally recognized technical profiles to demonstrate bi-directional communication in a health information exchange environment. the authors suggest that health departments explore the use of xforms or similar technologies to use xml documents for notifiable condition reporting and patient-specific public health alerting. patient-held health records have been used over the years to track health risks, vaccinations and other preventative health measures performed. there is evidence that mothers who have timely access to their health records and the records of their children have greater ability to track their own health and engage in prevention activities. their families tend to have better healthcare outcomes. in many developing countries, patient-held maternal and/or child health records are mostly paper-based. there is the urge in most countries to transfer these paper-based records into electronic formats. however, not enough is known about the health information seeking and utilization behavior in developing countries. in a paper entitled “patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries?” kathleen e. turner et al. explore, among other issues, maternal information needs regarding pregnancy, post-natal and infant healthcare. the study shows that that pregnant women and mothers from all different societies prefer to receive health information from a person, whether a healthcare provider, a friend, or family member. the authors recommend that, before investing significant resources in migrating current paper-based records into digital formats in developing countries, it is necessary study the information seeking behaviors of mothers and pregnant women. editorial: ojphi vol 3, no 2 (2011) 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 in modelling the spread of diseases within communities or populations, researchers are increasingly using agent based models (abm) due to their potential to capture complex emergent behaviours that arise from non-linearities of human contacts during the course of an epidemic. in a paper entitled “improving agent based models and validation through data fusion” marek laskowski et al. integrate data from emerging sources within discrete time and space disease spread abms, with application to respiratory infections that are primarily contracted through direct or proximal contact. the data sources include anonymized cell phone use records that help to estimate a person’s trajectory and a smartphone application using bluetooth enabled devices as proxies for people. a major advantage of using abms is that they lend themselves to inclusion of real data which is becoming increasingly available to researchers. this work demonstrates that incorporating data from disparate sources within an abm of the spread of infectious diseases has the potential to improve the credibility and validity of the model. overcrowding in emergency departments and longer waiting times are important problems facing healthcare administrators, especially in urban clinics. in a paper entitled “load balancing at emergency departments using ‘crowdinforming’,” friesen et al. utilize simulation models to explore crowdinforming as a process control strategy to balance patient loads among emergency departments in an urban setup. results suggest that emergency department performance could benefit from load balancing efforts. this model can be incorporated into disaster preparedness strategies aimed at optimizing the performance of urban clinics during major public health emergencies. while the outbreak of foodborne diseases has become a major public health problem very little research has been carried out on the implementation of food safety informatics as a technological tool to protect consumers in real time against foodborne illnesses. government inspectors, working through local health departments, depend primarily on paper-based documentation provided by businesses to verify that the foods we consume are free of contamination. recurring violations are handled through re-inspections or, in some cases, fines, suspension of permits, or closures of food facilities. to usher food safety surveillance into the information age cynthia tucker et al, in a paper entitled “food safety informatics: a public health imperative,” developed and piloted a wireless food safety informatics tool in a university student foodservice setting. the results of the study demonstrate the use of information technology in the detection of food safety abnormalities in real-time. it is not difficult at all to forecast the use of cloud computing to scale up the adoption of food safety informatics technologies by small businesses that cannot afford their own in-house technical personnel. loss of teeth is a major oral health problem in developing countries, resulting in nutritional deficiencies that affect the quality of life. this problem is more acute in the rural areas since dental specialists prefer to locate in urban areas where they can enjoy modern amenities. in a paper entitled “effectiveness of tele-guided interceptive prosthodontic treatment in rural india,” arun keeppanasserril et.al demonstrate that remotely supervised newly graduated general dentist can use telemedicine to provide over-dentures of sufficient quality to rural populations. this strategy has the potential to improve access to care and elevate the level of dentistry available to rural populations in developing countries. the results of the study indicate that dental public health policy makers in developing countries could leverage information and communication technology infrastructure to enhance access to dental care in rural areas. editorial: ojphi vol 3, no 2 (2011) 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 governments in developing and emerging economies have realized that the timely provision of accurate and updated health information is a pre-requisite for the achievement of a healthy society. most developing countries, however, are yet to transition to web-based health portals. in a paper entitled “internet-based public health information and statistics dissemination efforts for indonesia,” febiana hanani et al. describe health statistics dissemination efforts in indonesia, identify the factors that will facilitate the adoption web-based health portals, and develop a website for health statistics dissemination for indonesia. usability tests demonstrated promising results compared to the status quo. a major emphasis of the health information technology for economic and clinical health (hitech) act is the transition to accountable care organizations that use electronic medical records (emr). the goal of emr development must be to facilitate a patient-centered clinical encounter. neil nusbaum, in an article entitled “the electronic medical record and patientcentered care,” employs qualitative analysis to suggest that, patient-centric modifications to the emr architecture may also facilitate quality improvement and research activities. the working paper by wongyu lewis kim et al. describes development and implementation of a surveillance network system for emerging infectious diseases across three islands: martinique, st. lucia and dominica. the major objective of the “network of networks” surveillance system is to improve the responsiveness and representativeness of existing health systems through automated data collection, processing, and transmission of information from various sources. edward mensah, phd editor-in-chief online journal of public health informatics 1603 w taylor st, rm 757 chicago. il. 60612 email: dehasnem@uic.edu office: (312) 996-3001 ojphi-06-e88.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 124 (page number not for citation purposes) isds 2013 conference abstracts an evaluation of heat-related emergency department visits based on differences in heat syndrome definitions in northern illinois megan t. patel2 and stacey hoferka*1 1illinois deptartment of public health, chicago, il, usa; 2cook county department of public health, oak forest, il, usa � �� �� �� � � �� �� �� � objective ��� ����� ��� � ������ ��� �� ���� ���� � ��� �� ��� � �������� ���� ��� ����� � � �������������������������������� ��� introduction �� ��� ������������������������������� ���� �������� �������� ���� � �������������� ������ ���� ������� �� �������� �� ������������ �� ��������������� ����������������������� ����� � � ������ �������� � ������������������ � ���������������������� ����������� � ����� ����� � ��� ������ �� ��� ���� ��� ��� ��� ������ ��� ��� �� ���� ���� �� !��� ���� � ������� ������� ��� ���� ��� �� �� �� ������ �� ������� ��� ��� ���������������� ������ ���� ������� methods "����������������������� ����� � � ������������� ������# ����� �� $����� ����%#$&������ ���� ������� �� � ����������� � ����#''#(�#� ���� ��� ������� ����� ��(��������)�� �� ����� �*���+��,-+,��������� .������/+��,-+,�� ���������������� ����� � � ��������0�%�+&����� �������� ����1����2� ������ ���3��� ������� ����� � ��� � ��� ���%��&��%,&����� �������� � ����1����2������� ����� ������ � ������� ����� ��%$$&��%/&��3 ��� � �������2������� ����� �������#''#(�#������%4&�1������3 ��� ��2� ������ ����� �������5 �'�����,�-������6�����7������������������� ���� ������#''#(�#������������� ��������������������� ����� � � � �����������������������,-+,������� 8 ���� �� ���������� ����� � � ���������3� ���� ���������������� ��������� �� � ��������������� ��� �� ����� ��� ����� �������� �� ��� � � ����9�� ��������������� ����� � � ������������������������� ���� � ������������������ ���������������� ����� � � ������������ ���� ������ ����� � � ������������� �������������� �:����+�:����/+��,-+/� ��#''#(�#�����5 �'������������ �������� �� ����������������� ���������������������� ���� ��� ������������������������������� ��� ��� �������� ����� � ��� results ���� ������ �� ���� ��� �� ����� �� � ��� ���� ��� ���� ����� !��� ��� ������� ��� � /-;�<;<� � � ���� � ��� =->� ��� �������� �� ��� � �������� ���� � ����"���4?4��� ���������� ���� ����������� � ��� � ��� ������� ��� � ������� ����� ������� � � ���� ���� � �������� ���/4;�%@@>&� � � ��������� ���%������+&�� ���� �������!��������� �� ���� � ��� � ��� �������� �������� �� � �������������� � ������� ����� �� �������������������������� ��������� � ��� � ��� ������ ���������������� ������ �������!����� �������� ���� �� ��������� �������� ���� �������������������������������������� � �������� � ���� ���� � ������� �� � ������a�����%��� �&b�����3 ����� �������� ������� ��������3 ��� ������ �� ����������� ����� �� ����� �������������� ������ �������!����� �������� ���� �� ���������/@==�,�� ���@==,������������������3 ��� ������ �� ���� ��� ���� ����� ������ �� ��� � � ���� ����� ����� ������� ���� �� ������,� conclusions #� �������� ����� � � ��������������������� ��� ��������� ���� ����� ������������������������������ ����� ����� �� �������� � ������ ����3 �������������� �����a ����b������� ����� � � ����.� ���� � ��� ����� � � ������� �� ������ � ��� � ��� ����������� � ������� ����� �� ���� ������������������ ������� ������������������� ������������ ������� � � ��������� ���� �� �� ������������ ��������� � ��� ������ ���� ����� ����������� ����� ���������� ��� �������������� ������������ ���� �� �� � ��2������������� ���� � ��������� ������ ���� �� ������� ������ ������������� � � ������������ ����)������ ������ ����� ��������������������� ������� ��������� ������������� ��������������� ������� � � ���� ���� � ��� ��������"������� ��� �� ��� ���������3� �� ������������������� �������������������� � ��� � ��� �������� �� ������ ���������3����� ������ ������������� ����3������������ � �� ��� ���������� ���������� ������� ���������� ����� �� ������� ����� ��� � ��������������� ���� � � ��� ������ ��� ������ �������� ������� ������������ � � ��� �� � ��������� � ��� ��������3 ��� ��� ��� ������� ����� �������������������� � � ������� ������ ������������ ���������� � �������������������� ������ � � ������������� ��� ����� � ������� ������� ��� ������+��$ ������ �� ��� ���� ������������ ����� � � �� ������,��9�� ��������������� ����� � � ��� keywords c���d�'����� d��� ��� ��� *stacey hoferka e-mail: stacey.hoferka@illinois.gov� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e88, 2014 websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease ronak hamzehei1, masoumeh ansari2, shahabedin rahmatizadeh3, saeideh valizadeh-haghi4* 1. clinical research development unit of shahid beheshti hospital, hamadan university of medical sciences, hamadan, iran 2. medical educational and therapeutic center of kowsar, kurdistan university of medical sciences, sanandaj, iran 3. department of health information technology and management, school of allied medical sciences, shahid beheshti university of medical sciences, tehran, iran 4. department of medical library and information sciences, school of allied medical sciences, shahid beheshti university of medical sciences, tehran, iran abstract objectives: health service providers use internet as a tool for the spreading of health information and people often go on the web to acquire information about a disease. a wide range of information with varying qualities and by authors with varying degrees of credibility has thus become accessible by the public. most people believe that the health information available on the internet is reliable. this issue reveals the need for having a critical view of the health information available online that is directly related to people's life. the ebola epidemic is an emergency situation in the international public health domain and the internet is regarded as an important source for obtaining information on this disease. given the absence of studies on the trustworthiness of health websites on ebola, the present study was conducted to assess the trustworthiness of websites which are focused on this disease. methods: the term "ebola" was searched in google, yahoo and bing search engines. google chrome browser was used for this purpose with the settings fixed on yielding 10 results per page. the first 30 english language websites in each of the three search engines were evaluated manually by using the honcode of conduct tool. moreover, the official honcode toolbar was used to identify websites that had been officially certified by hon foundation. results: almost the half of the retrieved websites were commercial (49%). complementarity was the least-observed criterion (37%) in all the websites retrieved from all three-search engines. justifiability, transparency and financial disclosure had been completely observed (100%). discussion: the present study showed that only three criteria (justifiability, transparency and financial disclosure) out of the eight hon criteria were observed in the examined websites. like other health websites, the websites concerned with ebola are not reliable and should be used with caution. conclusion: considering the lack of a specific policy about the publication of health information on the web, it is necessary for healthcare providers to advise their patients to use only credible websites. websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi introduction nowadays the internet has become one of the dominant ways of obtaining health information and ranks first among the sources of health information. the internet is regarded as a reliable and accessible source of information for patients and other individuals [1], and one out of every three people uses the internet to obtain their health information [2]. the internet is used as a tool for the spreading of health information by health service providers and as a source for obtaining health information by patients. people often go on the web as the first step in acquiring some rudimentary data about a disease [1]. the health information available on the web allows for an interactive communication between the producers and consumers of the information. the positive features of the internet as the leading source of health information does not mean that we can overlook its negative attributes, because not all internet users know the proper method of searching for information, and the information stored on the web also lacks a proper classification, and these issues can make the search for health information difficult [3]. moreover, the internet is uncontrollable, and there is no authority for controlling the credibility and accuracy of the information available through it. furthermore, putting information on the web is easy, inexpensive or free, and anyone with any level of expertise can easily post information on this medium. a wide range of information with varying qualities and by authors with varying degrees of credibility has thus become accessible by the general public [4]. in addition, more than 80% of people believe that the health information available on the internet is reliable [5], and many of these consumers of health information do not consult with health specialists about the health information retrieved on the web[6]. this issue reveals the need for having a critical assessment of the health information available online that is directly related to people's life and health as well as for the evaluation of health websites by organizations and individuals. the health information published on the internet affects people's perceived health and the patients’ decisions about treatment choices [7]. the ebola epidemic is an emergency situation in the international public health domain [8]. the first outbreak of this disease started in 1976 in democratic republic of congo, and the other in south sudan in west africa. the 2014–2016 outbreak in west africa was the largest and most complex ebola outbreak since the virus was first discovered in 1976[9]. ebola virus disease is a seriously fatal. there is currently no standard treatment for this disease [10], and no vaccines have yet been developed to prevent it. since prevention is always better than cure, it is highly important furthermore, teaching them the criteria for assessing the trustworthiness of health websites would be helpful. keywords: patient portals, internet, online health information, ebola, self-care, patient education *correspondence: saeideh valizadeh-haghi, email: saeideh.valizadeh@gmail.com doi: 10.5210/ojphi.v10i3.9544 copyright ©2018 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. mailto:saeideh.valizadeh@gmail.com websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi for people to know about this disease, its development as well as prevention methods. in this regard, the internet is considered as an important source for obtaining this information. nonetheless, not all health websites are trustable, and some of them contain incorrect and unreliable information [3]. given the absence of studies on the trustworthiness of health websites in relation to ebola, the present study was conducted to assess the credibility of health websites that are focused on this disease. methods study samples and setting search engines are the first and main tools used to search for information on the web [11] and have a major role in obtaining medical and health information by non-specialists and specialists in medicine [12]. google, yahoo and bing are the three most popular search engines used by people around the globe [13,14]. for the present study, the term "ebola" was searched in these three search engines. google chrome browser was used for this purpose with the settings fixed on yielding 10 results per page. considering that most of search engine users only view the results appearing on the first three pages of their search [15,16], the first 30 websites in each of the three search engines were reviewed, making for a total of 90 results. the non-english websites, repetitive websites, articles in medical journals, non-relevant websites and inaccessible links were excluded from the assessment, and 43 out of the 90 retrieved websites were thus assessed (figure 1). data were collected through direct observation on dec. 5, 2017. figure 1: internet search flow diagram data collection tools there are various instructions and guidelines available for assessing the trustworthiness of health websites, and the health on the net foundation code of conduct (honcode) was selected for this research. this code is used in 102 countries for more than 7300 websites and 10 million pages as a reference for publishing health information [17]. the research tool consisted of a checklist websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi developed according to the honcode (figure 2). honcode has eight criteria: authoritative, complementarity, privacy, attribution, justifiability, transparency, financial disclosure and advertising policy[18]. this tool has been used in many studies for assessing the credibility of health websites[19-22]. the websites to be evaluated were divided into four categories: university, governmental, commercial and organizational. they were then manually assessed by ma and rh, and the validity of the resulting data was reassessed by sv and sr. the official honcode toolbar was used to identify websites that had been officially assessed. the data obtained were analyzed in spss-17. figure 2: honcode principles. the figure information is adopted from the hon website[18] results: of the 90 retrieved websites, 43 were unique and were assessed in this study. table 1 shows the frequency of the range of websites retrieved from google, bing and yahoo search engines compared to each other. with 20 results, google had the most unique pages retrieved. websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi table 1: the frequency of retrieved websites range in three search engines of bing, yahoo and google search engine number of retrieved sites duplicate websites no. of unique websites hon verified bing 30 3 8 2 yahoo 30 6 15 4 google 30 3 20 2 total 90 12 43 8 the reviewed websites were divided into four categories by domain: university, commercial, organizational and governmental (figure 3). many of the retrieved websites were commercial (49%). 49% 28% 16% 7% commercial organizational governmental educ ational figure 3: distribution of websites by domain address table 2 presents the consistency of the websites assessed with the hon criteria. complementarity was the least-observed criterion in all the websites retrieved from all three search engines. justifiability, transparency and financial disclosure had been completely observed (100%). in addition, of the 43 websites assessed, only eight had been officially approved by the honcode, and none of the other websites had fully observed the eight criteria of the hon. websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi table 2: evaluation results based on the components of hon criteria categorized by search engines search engine quality criterion google (n = 20) yahoo (n = 15) bing (n = 8) no. of websites (n = 43) authority 11 (55%) 8 (53%) 5 (62%) 24 (56%) complementarity 6 (30%) 7 (47%) 3 (37%) 16 (37%) privacy 18 (90%) 15 (100%) 8 (100%) 41 (95%) attribution 18 (90%) 15 (100%) 7 (87%) 40 (93%) justifiability 20 (100%) 15 (100%) 8 (100%) 43 (100%) transparency 20 (100%) 15 (100%) 8 (100%) 43 (100%) financial disclosure 20 (100%) 15 (100%) 8 (100%) 43 (100%) advertising policy 11 (55%) 12 (80%) 4 (50%) 27 (63%) discussion the present findings showed that the websites providing information about ebola have a poor degree of credibility, which agrees with the results of other studies conducted on health websites focusing on different issues [21,23-26]. governmental and university websites focused on health generally seek to provide educational information [27], but only 16% of the websites retrieved in the present study belonged to governmental organizations and 7% to universities. as in line with the results of previous studies [28,29], the majority of websites retrieved at the present study (43%) were commercial. compared to other websites, commercial websites have poor quality and credibility [30,31]. therefore, while searching information on ebola, people come across websites that are less valid than other websites and that may obtain incorrect information that could put their health at risk. it should be noted that merely being a university website does not ensure the higher quality of the information contained [32], and the accuracy of the information available on these websites should also be assessed. in the present study, of the 43 websites assessed, only eight had been officially assessed by the hon foundation, which agrees with the results of other studies conducted on similar subjects [33,34]. these websites are examples of websites that users will come across when searching information on ebola. to help empower patients for facing various diseases, including ebola, access to valid websites that contain high-quality information will be beneficial. non-compliance with the hon criteria in the examined websites shows that users will come across less credible websites that may contain poor-quality information, which affects their proper decision-making about the prevention and treatment of ebola. websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi health information written by specialists are more reliable [35]. nevertheless, in the present study, just 56% of the websites had specified the name and specialization of the author(s). also in a similar research that investigated testicular websites, only 32% of the examined websites had specified the author's name [33] while observing this criterion is indicative of the validity and trustworthiness of the information source [35]. the medical information provided on health websites should not replace the direct doctor-patient relationship. in fact, the information provided on websites is for the purpose of support and education and cannot replace consultation with a doctor who is directly in contact with the patient. this point should be clearly stated on health websites. in the present study, however, only 37% of the examined websites had declared this point. given that only a small percentage of people consult with their doctor regarding the health information retrieved online [36], it is imperative for health websites to pay greater attention to this criterion. so that people can be well informed and refrain from replacing their doctor with the medical information obtained from health websites and will use online information after further consultation with the doctors. the present study showed that only three criteria (justifiability, transparency and financial disclosure) out of the eight hon criteria were observed in the examined websites (table 2). same as other health websites [24,25,37,38], the websites concerned with ebola are not reliable and should be used with caution. nevertheless, it should be noted that the hon criteria do not necessarily show the quality of the information published on a website and merely indicate the credibility of the website itself. patients and other users of online health information should carefully assess the quality of the information retrieved through websites, even if this information has been obtained from credible websites. given the importance of the internet in spreading health information and its extensive use for obtaining health information and given that only a small percentage of people consult with their doctor about the medical information obtained on the web, thus, clinicians have a key role in guiding patients to using trustable websites, so that they can make informed decisions about diseases and their health. conclusions considering the lack of a specific law or policy about the publication of health information on the web, it is necessary for healthcare providers to advise their patients to use only credible websites that contain quality information. furthermore, it is necessary to teach them the criteria for assessing the trustworthiness of health websites. people's knowledge of health website evaluation tools such as the honcode for identifying and using websites with a higher credibility will help them use better and higher-quality information. people will thus be able to have a better understanding of their health and can make more informed decisions about their health and illness. also, since people use the internet to obtain health information and in the absence of a unique tool used globally for the assessment of health websites, it is essential for doctors to know about their patients’ use of online information, so that they can guide them to trustable and high-quality websites. websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi financial disclosure this research was funded by the school of allied medical sciences, shahid beheshti university of medical sciences (grant number 10571). references 1. zickuhr k, smith a. digital differences. pew internet and american life project. available at: http://pewinternet. org/reports/2012/digital-differences. aspx (accessed february 2014); 2012. 2. van de belt th, engelen lj, berben saa, teerenstra s, samsom m, et al. 2013. internet and social media for health-related information and communication in health care: preferences of the dutch general population. j med internet res. 15(10), e220. pubmed https://doi.org/10.2196/jmir.2607 3. cline rjw, haynes km. 2001. consumer health information seeking on the internet: the state of the art. health educ res. 16(6), 671-92. pubmed https://doi.org/10.1093/her/16.6.671 4. kaicker j, debono vb, dang w, buckley n, thabane l. 2010. assessment of the quality and variability of health information on chronic pain websites using the discern instrument. bmc med. 8(1), 59. pubmed https://doi.org/10.1186/1741-7015-8-59 5. beredjiklian pk, bozentka dj, steinberg dr, bernstein j. evaluating the source and content of orthopaedic information on the internet: the case of carpal tunnel syndrome. j bone jt surg ser a. 2000;82(11):1540–3. 6. fox s. online health search 2006. pew internet & american life project; 2006. 7. nan x, madden k. 2012. hpv vaccine information in the blogosphere: how positive and negative blogs influence vaccine-related risk perceptions, attitudes, and behavioral intentions. health commun. 27(8), 829-36. pubmed https://doi.org/10.1080/10410236.2012.661348 8. love cb, arnesen sj, phillips sj. 2015. ebola outbreak response: the role of information resources and the national library of medicine. disaster med public health prep. 9(1), 8285. pubmed https://doi.org/10.1017/dmp.2014.108 9. ebola virus disease [internet]. who. 2018 [cited 2018 nov 26]. available from: http://www.who.int/news-room/fact-sheets/detail/ebola-virus-disease 10. tseng c-p, chan y-j. 2015. overview of ebola virus disease in 2014. j chin med assoc. 78(1), 51-55. pubmed https://doi.org/10.1016/j.jcma.2014.11.007 11. bilal d. 2012. ranking, relevance judgment, and precision of information retrieval on children’s queries: evaluation of google, yahoo! bing, yahoo! kids, and ask kids [internet]. websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi j am soc inf sci technol. 63(9), 1879-96. http://doi.wiley.com/10.1002/asi.22675. doi:10.1002/asi.22675. 12. wang l, wang j, wang m, li y, liang y, et al. 2012. using internet search engines to obtain medical information: a comparative study. j med internet res. 14(3), e74. pubmed https://doi.org/10.2196/jmir.1943 13. alexa. the top 500 sites on the web [internet]. [cited 2010 aug 20]. available from: https://www.alexa.com/topsites%0ahttp://www.alexa.com/topsites 14. gkouskou k, markaki a, vasilaki m, roidis a, vlastos i. 2011. quality of nutritional information on the internet in health and disease [pubmed]. hippokratia. 15(4), 304. 15. promislow s, walker jr, taheri m, bernstein cn. 2010. how well does the internet answer patients’ questions about inflammatory bowel disease? [pubmed]. can j gastroenterol. 24(11), 671-77. 16. iprospect blended search results study 2008 [internet]. [cited 2017 sep 10]. available from: http://www.iprospect.com 17. the commitment to reliable health and medical information on the internet [internet]. health on the net foundation. 2018. available from: http://healthonnet.org/honcode/pro/visitor/visitor.html 18. the hon code of conduct for medical and health web sites (honcode) [internet]. [cited 2017 nov 10]. available from: http://www.hon.ch/honcode/ 19. saraswat i, abouassaly r, dwyer p, bolton dm, lawrentschuk n. 2016. female urinary incontinence health information quality on the internet: a multilingual evaluation. int urogynecol j. 27(1), 69-76. pubmed https://doi.org/10.1007/s00192-015-2742-5 20. grohol jm, slimowicz j, granda r. 2014. the quality of mental health information commonly searched for on the internet. cyberpsychol behav soc netw. 17(4), 216-21. pubmed https://doi.org/10.1089/cyber.2013.0258 21. hanna k, brennan d, sambrook p, armfield j. 2015. third molars on the internet: a guide for assessing information quality and readability. interact j med res. 4(4), e19. pubmed https://doi.org/10.2196/ijmr.4712 22. lawrentschuk n, sasges d, tasevski r, abouassaly r, scott am, et al. 2012. oncology health information quality on the internet: a multilingual evaluation. ann surg oncol. 19(3), 706-13. pubmed https://doi.org/10.1245/s10434-011-2137-x 23. ellsworth b, patel h, kamath af. 2016. assessment of quality and content of online information about hip arthroscopy. arthroscopy. 32(10), 2082. pubmed https://doi.org/10.1016/j.arthro.2016.03.019 websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi 24. valizadeh-haghi s, rahmatizadeh s. 2018. evaluation of the quality and accessibility of available websites on kidney transplantation [pubmed]. urol j. 15(5), 261-26. 25. rahmatizadeh s, valizadeh-haghi s. 2018 evaluating the trustworthiness of consumeroriented health websites on diabetes. libr philos pract. 4 26. shahrabifarahani n. shekofteh m. kazerani m, emami z. an evaluation of persian diabetes websites based on webmedqual (2016). iran j endocrinol metab [internet]. 2018 oct 15 [cited 2018 nov 1];20(3):142–50. available from: http://ijem.sbmu.ac.ir/article-1-2352en.html 27. cancer information on the internet [internet]. vol. 2017. american cancer society; 2016 [cited 2018 feb 20]. available from: http://www.cancer.org/cancer/cancer-basics/cancerinformation-on-the-internet.html 28. lópez-jornet p, camacho-alonso f. the quality of internet information relating to oral leukoplakia. med oral patol oral cir bucal [internet]. 2010 [cited 2018 mar 19];15(5):727– 31. available from: http://www.medicinaoral.com/medoralfree01/v15i5/medoralv15i5p727.pdf 29. bruce-brand ra, baker jf, byrne dp, hogan na, mccarthy t. 2013. assessment of the quality and content of information on anterior cruciate ligament reconstruction on the internet. arthroscopy. 29(6), 1095-100. pubmed https://doi.org/10.1016/j.arthro.2013.02.007 30. khazaal y, chatton a, cochand s, zullino d. 2008. quality of web-based information on cocaine addiction [internet]. patient educ couns. 72(2), 336-41. http://www.ncbi.nlm.nih.gov/pubmed/18423952. pubmed https://doi.org/10.1016/j.pec.2008.03.002 31. ostry a, young ml, hughes m. 2007. the quality of nutritional information available on popular websites: a content analysis. health educ res. 23(4), 648-55. pubmed https://doi.org/10.1093/her/cym050 32. lee s, shin jj, haro ms, song sh, nho sj. 2014. evaluating the quality of internet information for femoroacetabular impingement. arthroscopy. 30(10), 1372-79. pubmed https://doi.org/10.1016/j.arthro.2014.04.102 33. prasanth as, jayarajah u, mohanappirian r, seneviratne sa. 2018. assessment of the quality of patient-oriented information over internet on testicular cancer. bmc cancer. 18(1), 491. pubmed https://doi.org/10.1186/s12885-018-4436-0 34. perzel s, huebner h, rascher w, menendez-castro c, hartner a, et al. searching the web: a survey on the quality of advice on postnatal sequelae of intrauterine growth restriction and the implication of developmental origins of health and disease. in: journal of developmental origins of health and disease. 2017. p. 604–12. websites as a tool for public health education: determining the trustworthiness of health websites on ebola disease online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e221, 2018 ojphi 35. evaluating health information [internet]. university of california. 2016 [cited 2018 feb 20]. available from: https://www.ucsfhealth.org/education/evaluating_health_information/ 36. fast am, deibert cm, hruby gw, glassberg ki. 2013. evaluating the quality of internet health resources in pediatric urology [internet]. j pediatr urol. 9(2), 151-56. http://www.ncbi.nlm.nih.gov/pubmed/22281281. pubmed https://doi.org/10.1016/j.jpurol.2012.01.004 37. elliott adad, bartel afpaf, simonson d, roukis tsts. is the internet a reliable source of information for patients seeking total ankle replacement? j foot ankle surg. 2015/03/10. 2015;54(3):378–81. 38. sullivan tb, anderson jt, ahn um, ahn nu. 2014. can internet information on vertebroplasty be a reliable means of patient self-education? clin orthop relat res. 472(5), 1597-604. pubmed https://doi.org/10.1007/s11999-013-3425-5 satscan on the cloud satscan on a cloud: on-demand large scale spatial analysis of epidemics 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 satscan on a cloud: on-demand large scale spatial analysis of epidemics ronald c price 1 , warren pettey 2 , tim freeman 3 , kate keahey 3 , molly leecaster 2 , matthew samore 2 , james tobias 4 , julio c facelli 1,5 1 center for high performance computing, departments of internal medicine 2 and biomedical informatics 5 , the university of utah 3 mathematics and computer science division of argonne national laboratory 4 national center for public health informatics, centers for disease control abstract: by using cloud computing it is possible to provide ondemand resources for epidemic analysis using computer intensive applications like satscan. using 15 virtual machines (vm) on the nimbus cloud we were able to reduce the total execution time for the same ensemble run from 8896 seconds in a single machine to 842 seconds in the cloud. using the cabig tools and our iterative software development methodology the time required to complete the implementation of the satscan cloud system took approximately 200 man-hours, which represents an effort that can be secured within the resources available at state health departments. the approach proposed here is technically advantageous and practically possible. introduction satscan [1] is a computer intensive application that is commonly used to detect cluster characteristics of epidemics that provide decision support to epidemiologists. in practical applications long ensemble runs of satscan provide public health analysts with insight into the epidemics’ progression that result in higher confidence policy decisions. satscan ensemble runs test the alternative hypothesis that there is elevated disease risk within a defined cluster. the estimated p-value for these tests is based on the rank of the likelihood from the real data compared to that from the random data sets generated during the monte carlo randomizations. this rank is conditional on the random data sets generated and if the random seed were not set to a constant would vary for each replication of the software run. although only one random set is realized, it is part of a distribution of possible ranks if the random seed were allowed to vary. the variance in this distribution depends on the number of monte carlo realizations. the more monte carlo realizations that are run, the variance in the p-value will be smaller and the estimate will be closer to the true p-value. for decisions in epidemiology that involve possible implementation of contact tracing or other satscan on a cloud: on-demand large scale spatial analysis of epidemics 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 expensive and invasive processes where the statistical significance is close to the decision threshold, an estimated p-value close to the truth is especially important. an estimated p-value from a small number of monte carlo realizations has a greater chance of under or over estimating the truth and leading to an incorrect decision. an estimated p-value from a large number of monte carlo realizations is closer to the true value and is more likely to lead to a correct decision. unfortunately, ensemble runs long enough to provide adequate confidence in decisions require computational resources that are usually beyond those available at typical health department analytical facilities. cloud computing provides such resources without deploying extensive computational resources for very limited and sporadic use. moreover, cloud resources could be implemented on top of existing infrastructures dedicated to routine office tasks in public health departments or similar organizations. similar work reported in the literature includes the visual statistical data analyzer (visda), a grid-based analytical tool [2,3] that includes spatial analyses, and work done using the open-source grid-computing technology to improve processing time for geospatial syndromic surveillance [4]. both projects illustrated the value of grid computing in spatial analysis. our work leverages the cloud which has the ability to be flexible in the amount of nodes involved and is not limited by hardware constraints in terms of amount of computer resources available. moreover, the cloud provides resources at a much lower level of abstraction than grids and eliminates many of the cumbersome infrastructural and sharing agreements needed to deploy computational grids [5]. this paper reports our successful implementation of a satscan cloud system using the nimbus tp2.x software [6]. to demonstrate its use we present the analysis of epidemic data from high-fidelity, agent-based simulation of pertussis epidemics. the model was built by the virginia bioinformatics institute using their episimdemics simulation platform [7] and consists of the space-time details of 2.2 million in silico individuals modeled after utah population and physical geography [8]. this model maintains a disease profile for each individual that simulates both the presence and severity of symptoms, infectivity, and likelihood for seeking the help of a doctor. individuals who were treated became less infectious or non-infectious once treated. the disease transmission model was based on the van rie and hethcote compartmental model for pertussis [9]. methods design decisions & software implementation while the work presented here could be implemented using soap, the wsrf implementation is a better approach because it allows the integration of the cloud version of satscan into emerging public health grid infrastructures [10, 11]. at the time of this implementation the only wsrf (grid) solution for cloud computing accessible to the authors was the nimbus cloud deployed at argonne national lab. nimbus is an open source toolkit satscan on a cloud: on-demand large scale spatial analysis of epidemics 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 that allows developers to turn a cluster into an infrastructure-as-a-service (iaas) cloud (http:// workspace.globus.org). we accomplished our implementation using an iterative development approach with short iterations: iteration 1 involved installing and configuring satscan on a linux based computer at the university of utah and then wrapping satscan into a grid service; iteration 2 consisted of the deployment of this service on the argonne nimbus cloud; and, the final stage consisted of testing the performance and scalability of the cloud version of satscan. a major design decision that we faced was where to implement the cloud client logic that would provide the on-demand functionality of the satscan cloud system. the choice was either to create a grid service that had the ability to stand-up satscan grid services and another grid service that could be invoked to run satscan jobs or to create a single satscan grid service that could perform both functions. because the nimbus server provides a general interface that allows users to stand-up various virtual machines, such as the satscan grid node virtual machine, there was no need to duplicate the nimbus server-side capability to stand up a virtual machine (vm), greatly simplifying our deployment efforts. satscan is a legacy application and in order to rapidly create a satscan grid service we used introduce, gravi and the cagrid portal [12]. these tools and others developed by the cagrid project (http://cagrid.org/display/introduce/home) provide a set of tools and a layer of abstraction around globus ws-core that significantly reduce the amount of effort required to deploy grid services. introduce is an extensible toolkit to support easy development and deployment of ws/wsrf compliant grid services by hiding low level details of the globus toolkit and enabling the semi automatic implementation of stronglytyped grid services. introduce has many useful plug-ins that are also available for further assistance. we used the grid rapid application virtualization interface (gravi), a plug-in that allowed us to quickly wrap and deploy legacy application as globus compliant grid services (http://dev.globus.org/wiki/incubator/gravi). our development started by determining the parameter set required to execute satscan from the command line, then we used gravi and introduce to wrap the satscan command line interface into a grid service. the cagrid portal provided an efficient and effective way to verify that the satscan grid service was deployed correctly. the cagrid portal leverages google maps to depict grid services from the particular grid for which it has been configured. to test the deployment of the satscan grid service we used the cagrid training grid. as depicted in figure 1, the satscan grid service appears correctly on the cagrid portal implying that the deployment has been successful. to verify that the satscan grid service was functional, we invoked the service using the satscan grid service client that was also created automatically by introduce and gravi. http://cagrid.org/display/introduce/home http://dev.globus.org/wiki/incubator/gravi satscan on a cloud: on-demand large scale spatial analysis of epidemics 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 1: the cabig portal for the test grid showing that the satscan grid service has been deployed successfully in salt lake city. ut to demonstrate the dynamic scalability of our grid service with the goal to provide the on-demand satscan computer resources, we used the argonne national lab nimbus cloud. to accomplish this we used the satscan grid service implemented on a linux vm. the vm editing features available on the nimbus client-side allowed us to use an existing linux vm and edit it as needed. as part of the customization we added the cagrid software stack, the satscan grid service and configured a minimum of necessary services to initialize at boot time. at this point we were able to successfully stand-up a satscan grid node on-demand on the cloud and invoke it from a remote client. in order to automatically manage the satscan clients we created a handler using the bash programming language. this handler, satscan handler, manages all aspects of each satscan grid client including stage-in, job status progress and stage-out. the architecture of the handler is similar to the one used in our previous reported work on digital sherpa [13]. satscan on a cloud: on-demand large scale spatial analysis of epidemics 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 scaling tests for the scaling experiments we were able to stand-up up to 15 vms in the argonne nimbus cloud. the first step in this process is to dynamically acquire the resources (vms) needed for the desired run by invoking the nimbus workspace service using the nimbus workspace client. fig. 2 depicts the different systems involved in this process. figure 2: initializing dynamic allocation of vms using the nimbus workspace service once the nimbus work space service has been secured it is possible to start booting the linux vm with the satscan grid services. the system obtained after the boot process completes is depicted in fig. 3 satscan on a cloud: on-demand large scale spatial analysis of epidemics 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 3: satscan vms have been dynamically acquired and deployed in the cloud. they are ready to execute ensemble runs as they are sent by the satscan clients managed by the satscan handler. the satscan handler manages the ensemble runs, which for these tests included up to 15 satscan grid clients. as depicted in fig. 3, each satscan grid client in the satscan handler submits a single satscan run to be processed by a satscan grid service, which delivers the task to the satscan executable. upon completion the client moves the output files to the local host and the satscan handler assembles the complete output of the ensemble run. we prepared satscan’s instruction files (.prm) to run a total of 9,990 monte carlo simulations using the same data files on 5, 8, 12, 13 and 15 vms running the satscan grid services, but using different seeds for the satscan’s random number generator. the data files satscan on a cloud: on-demand large scale spatial analysis of epidemics 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 included all 2.2 million individuals divided into the 292 utah zip codes (population & coordinates files) for the full 210 simulated days (the full duration of the simulation) with resolution at the “day” level. a total of 4,521 cases were reported in the “case” file. for analysis type, we set satscan to run a retrospective space-time analysis using a poisson distribution that assumes rare events. aggregated and packaged data files for satscan, including case, coordinates and population, were approximately 1 mb and each of the satscan instruction files was approximately 8 kb. these are relatively small files and their transfer across the network does not increase the execution times significantly. each vm in the cloud received approximately equal numbers of monte carlo simulations that are inversely proportional to the total number of vms involved. for example, if we have ten vms each one received 999 monte carlo replicates to compute. to establish a base line performance we also instructed one single node to run all 9990 monte carlo replicates using the same data files and analysis instructions. we verified that satscan ensemble runs performed in parallel on the cloud produce the same results as the sequential runs. results and discussion to evaluate the potential usefulness of the satscan cloud service for prospective users, we addressed the following user-oriented questions: when a user requests a cloud vm from the grid service, how long will it take before the vm is available for use? when using the cloud, what is the overhead incurred by the calculations? what is the overall speed up of the calculations and how does it reflect on the perceived turnaround? the turnaround time of the simulations, which these questions address, is paramount for epidemiologists. depending on the results of each simulation they must decide on either performing new simulations or taking preventive action through normal public health communication channels. the first question was addressed under the assumption that there is no contention for the requested resources, i.e. we measured the time required to stand up a cloud node as the cumulative time of transferring the os image that represents the vm and booting the guest os on the nimbus cloud. further delays may be observed if the cloud available to the runs is oversubscribed. in order to make boot-up faster we created an image that initializes as few services as possible. using this strategy we were able to reduce the time needed for one node to boot from 283 seconds to 207 seconds (all times plus or minus 10-15 seconds). we also tried compressing the image to improve transfer time but the overhead due to the time required to uncompress the image far outweighed the benefits. while this overhead is significant, it is only a small fraction of the total execution time of a typical ensemble run, for comparison our 9,990 monte carlo ensemble run required approximately 8,996 seconds in a single processor. satscan on a cloud: on-demand large scale spatial analysis of epidemics 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 to address the second question we ran 999 and 9,990 monte carlo replicas. the execution times without the vm and the grid services overhead were 901 seconds and 8,996 seconds, respectively. when running the satscan grid service on a vm these times increased to 1,078 seconds and 10,700 seconds, respectively. this represents an increase of 10.87 % and 18.99 % of the execution time; the slow down for a larger job can be attributed to the deeper software stack and vm cpu overhead. table 1: scalability results of the satscan grid services provided in the nimbus cloud (execution times in seconds). vms execution time speedup replicates per node 1 10700 1 9990 5 2144 4.99 1998 8 1289 8.30 1249 10 986 10.85 999 13 725 14.75 769 15 635 16.85 666 to address the third question we compared the run of a satscan job of 9,990 monte carlo replicates on a single vm using the satscan grid service with the execution of the same number of monte carlo replicas in different number of nodes using also the vms and the satscan grid services. the results are entered in table 1 and fig. 4. the excellent scaling (for a constant size problem) depicted in the table is due to the nature of ensemble runs with embarrassing parallel characteristics. in parallel computing, an embarrassingly parallel workload is one for which little or no effort is required to separate the problem into a number of parallel tasks. this is often the case when no dependency (or communication) exists between the parallel tasks. http://en.wikipedia.org/wiki/parallel_computing satscan on a cloud: on-demand large scale spatial analysis of epidemics 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 4: total execution time of satscan on the nimbus cloud as function of the number of vms used. execution times are in seconds. moreover, the overhead incurred by using a vm increases with the number of monte carlo replicates, and by running multiple copies of smaller number of replicates we are able to reduce this overhead, leading to the super-linear scaling depicted in table 1. the scaling depicted in table 1 is excellent, but for large number of vms the start up cost may become a potential bottle neck. for the levels of parallelism explored here we believe that our results demonstrate that using a cloud approach provides ondemand computational resources for epidemiology surveillance. it is remarkable that when using 15 vms the total execution time of 842 seconds, which includes 635 seconds of execution and the 207 seconds needed to stand up the vms, is one order of magnitude smaller than the 8,896 seconds required to run the complete ensemble in one machine. conclusions by using cloud computing and a computer intensive application like satscan, it is possible to provide on-demand resources for epidemic analysis. therefore, implementing a cloud across the existing internal infrastructure of a health department may be a viable approach for large-scale epidemiology surveillance on demand. we have demonstrated that when using satscan we achieved an order of magnitude improvement in the turnaround, making possible a detailed analysis that may not be possible with the typical resources existing in public health departments. the techniques used for satscan on the cloud could be generalized to any application that exhibits substantial parallel content. using the cabig tools and our software development methodology the time required to complete implementation took approximately 200 man-hours, an effort that could be secured with typical state health department resources. the approach proposed here is technically advantageous and can be practically implemented. satscan on a cloud: on-demand large scale spatial analysis of epidemics 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 acknowledgements this work was partially funded by the centers for disease control and prevention through the rocky mountain center of excellence in public health informatics # 1p01hk000069-10, national library of medicine training grant # lm007124 and ncrr clinical and translational science award 1kl2rr025763-01. conflicts of interest: the authors do not declare any conflict of interest. references [1] kulldorff m, nagarwalla n. spatial disease clusters: detection and inference. stat med 14(8):799-810. [2] wang j, li h, zhu y, yousef m, nebozhyn m, showe m, et al. visda: an open-source cabig analytical tool for data clustering and beyond. bioinformatics 2007; 23(15):2024-7. [3] zhu y, li h, miller dj, wang z, xuan j, clarke r, et al. cabig visda: modeling, visualization, and discovery for cluster analysis of genomic data. bmc bioinformatics 2008; 9:383. [4] grannis s, olson k, egg j, overhage jm. using open-source grid-computing technology to improve processing time for geospatial syndromic surveillance data. advances in disease surveillance 2006. [5] rings t, caryer g, gallop j, grabowski j, kovacikova t, schulz s, et al. grid and cloud computing: opportunities for integration with the next generation network. journal of grid computing 2009; 7(3):375-93. [6] keahey k, freeman t, editors. science clouds: early experiences in cloud computing for scientific applications,. cloud computing and its applications (cca-08); 2008; chicago, il. [7] barrett c, bisset k, eubank sg, feng x, m m, editors. episimdemics: an efficient and scalable framework for simulating the spread of infectious disease on large social networks. international conference for high performance computing, networking, storage and analysis (sc08); 2008; austin, texas. [8] pettey w, benuzillo j, walker b, parks a, kramer h, gesteland p, rubin m, drews f, livnat y, samore m. using agent-based simulations of infectious disease spread to enhance public health decision support tools. american public health association 173th annual meeting; 2009; philadelphia. [9]van rie a, hw. h. adolescent and adult pertussis vaccination: computer simulations of five new strategies. vaccine 2004; 22:3154-65. [10] staes c, xu w, lefevre s, price r, narus s, gundlapalli a, et al. a case for using grid architecture for state public health informatics: the utah perspective. bmc medical informatics and decision making 2009; 9(1):32. [11] staes cj, xu w, lefevre sd, narus sp, gundlapalli a, samore m, et al. a case for using grid architecture in state public health informatics: the utah perspective. helthgrid 2008; chicago 2008. [12] oster s, langella s, hastings s, ervin d, madduri r, phillips j, et al. cagrid 1.0: an enterprise grid infrastructure for biomedical research. j am med inform assoc 2008 marapr;15(2):138-49. satscan on a cloud: on-demand large scale spatial analysis of epidemics 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 [13] price rc, wayne bb, victor eb, julio cf. digital sherpa: a set of high level tools to manage scientific applications in a computational grid. proceedings of the 15th acm mardi gras conference: from lightweight mash-ups to lambda grids: understanding the spectrum of distributed computing requirements, applications, tools, infrastructures, interoperability, and the incremental adoption of key capabilities; baton rouge, louisiana: acm; 2008. layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts fusion analytics: a data integration system for public health and medical disaster response decision support dina b. passman* aspr/opeo, hhs, washington, dc, usa objective the objective of this demonstration is to show conference attendees how they can integrate, analyze, and visualize diverse data type data from across a variety of systems by leveraging an off-the-shelf enterprise business intelligence (ebi) solution to support decisionmaking in disasters. introduction fusion analytics is the data integration system developed by the fusion cell at the u.s. department of health and human services (hhs), office of the assistant secretary for preparedness and response (aspr). fusion analytics meaningfully augments traditional public and population health surveillance reporting by providing webbased data analysis and visualization tools. methods fusion analytics serves as a one-stop-shop for the web-based data visualizations of multiple real-time data sources within aspr. the 24-7 web availability makes it an ideal analytic tool for situational awareness and response allowing stakeholders to access the portal from any internet-enabled device without installing any software. the fusion analytics data integration system was built using off-the-shelf ebi software. fusion analytics leverages the full power of statistical analysis software and delivers reports to users in a secure web-based environment. fusion analytics provides an example of how public health staff can develop and deploy a robust public health informatics solution using an off-the shelf product and with limited development funding. it also provides the unique example of a public health information system that combines patient data for traditional disease surveillance with manpower and resource data to provide overall decision support for federal public health and medical disaster response operations. conclusions we are currently in a unique position within public health. one the one hand, we have been gaining greater and greater access to electronic data of all kinds over the last few years. on the other, we are working in a time of reduced government spending to support leveraging this data for decision support with robust analytics and visualizations. fusion analytics provides an opportunity for attendees to see how various types of data are integrated into a single application for population health decision support. it also can provide them with ideas of how they can use their own staff to create analyses and reports that support their public health activities. keywords situational awareness; public health informatics; disaster response *dina b. passman e-mail: dina.passman@hhs.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e207, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts implications of icd-9/10 cm transition for public health surveillance: challenges, opportunities, and lessons learned from multiple sectors of public health peter hicks*1 and atar baer2 1cdc, atlanta, ga, usa; 2public health seattle and king county, seattle, wa, usa objective to provide a forum for local, state, federal, and international public health/ health care sectors to share promising practices and lessons learned in transitioning their organizations in the use of icd-9 to icd-10 codes for their respective surveillance activities. introduction this roundtable will provide forum for a diverse set of representatives from the local, state, federal and international public health care sectors to share tools, resources, experiences, and promising practices regarding the potential impact of the transition on their surveillance activities. this forum will promote the sharing of lessons learned, foster collaborations, and facilitate the reuse of existing resources without having to “reinvent the wheel”. it is hope that this roundtable will lay the ground-work for a more formal, collaborative, and sustainable venue within isds to aid in preparing the public health surveillance community for the coming icd-9/10 cm transition. methods the moderators will engage the participants in the discussion through dialogue in how their programs are currently using icd-9 cm codes for surveillance and how the transition will impact their respective programs. keywords icd-9; icd-10; transition *peter hicks e-mail: phicks@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e194, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts biosense 2.0 kelley g. chester* rti international, milton, ga, usa objective to familiarize public health practitioners with the biosense 2.0 application and its use in all hazard surveillance. introduction biosense 2.0 protects the health of the american people by providing timely insight into the health of communities, regions, and the nation by offering a variety of features to improve data collection, standardization, storage, analysis, and collaboration. biosense 2.0 is the result of a partnership between the centers for disease control and prevention (cdc) and the public health community to track the health and well-being of communities across the country. in 2010, the biosense program began a redesign effort to improve features such as centralized data mining and addressing concerns that the system could not meet its original objective to provide early warning or detect local outbreaks. methods using the latest technology, biosense 2.0 integrates current health data shared by health departments from a variety of sources to provide insight on the health of communities and the country. by getting more information faster, local, state, and federal public health partners can detect and respond to more outbreaks and health events more quickly. from flu outbreaks to car accidents, biosense 2.0 provides the critical data, information, and tools that public health officials need to better understand and address health problems at the local, state, regional, and national levels. also, by knowing what is happening across local borders, public health professionals can anticipate potential health problems and respond effectively to protect the health of all people. the demonstration will include a basic overview of the biosense 2.0 application and the functionality available to public health departments and their data providers. the presenter will also show an example of how biosense 2.0 can be used in a real-world public health example. conclusions over the past two years much has been accomplished during the redesign effort. biosense 2.0 was launched in november of 2011 and the collaboration between the biosense program and the public health community has yielded an application based on a user-centered design approach and built on a platform that allows for flexible data sharing across jurisdictions and with partners. the public health community has played a critical role in designing and improving the biosense 2.0 application and through continued collaboration the system will continue to improve. innovative features of the biosense 2.0 application include the use of cloud technology, a novel and flexible data sharing feature, a community driven approach, enhanced algorithms, and no cost statistical analysis tools available in the cloud. each of these features will be discussed during the presentation. keywords syndromic surveillance; informatics; situation awareness *kelley g. chester e-mail: kchester@rti.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e200, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts using syndromic emergency department data to augment oral health surveillance john p. jasek*1, nicole hosseinipour1, talia rubin1 and ramona lall2 1nyc department of health and mental hygiene, bureau of health care access and planning, long island city, ny, usa; 2nyc department of health and mental hygiene, bureau of communicable diseases, long island city, ny, usa objective to utilize an established syndromic reporting system for surveillance of potentially preventable emergency department (ed) oral health visits (ohv) in new york city (nyc). introduction nyc department of health and mental hygiene recently reoriented its oral health care strategy to focus on health promotion and expanded surveillance. one surveillance challenge is the lack of timely ohv data; few dental providers are in our electronic health record project, and statewide utilization data are subject to delays. prior research has examined ohv using icd-9-cm from ed records, and has suggested that diagnostic specificity may be limited by ed providers’ lack of training in dental diagnoses (1-3). we considered our existing ed syndromic system as a complement to periodic population-based surveys. this system captures approximately 95% of all ed visits citywide; 98% of records have a completed chief complaint text field whereas only 52% contain an icd-9-cm diagnosis. methods we used chief complaint text to define ohv in two ways: (1) a basic definition comprised of ‘tooth’ or ‘gum’ in combination with a pain term (e.g., ‘ache’); (2) a more inclusive definition of either specific oral health diagnoses (e.g., ‘pulpitis’) or definition (1). for both definitions, we excluded visits likely to have stemmed from trauma (e.g., ‘accident’). data from 2009-2011 were analyzed by facility, patient age and residential zip code, and day/time using sas v9.2 (sas institute; cary, nc). results ohv in 2009-2011 totaled 72,410 (def. 1) and 103,594 (def. 2), or 0.6% and 0.9% of all ed visits, respectively. ohv (def. 2) spiked at age 18 and were highest among 18 to 29 year olds (fig. 1). neighborhood ohv rates (def. 2) ranged from 74 to 965 per 100,000 persons. 59% of ohv occurred between 8am and 6pm (fig. 2). highly specific dental conditions were rare; terms such as “tooth ache” were most common. conclusions findings suggest that ohv are a particular problem among ages 18 to 29. this pattern may reflect lower insurance coverage among young adults. the proportion of daytime visits suggests that eds are substituting for regular dental treatment and there may be opportunities to promote daytime linkages to office-based dental providers. a well-established syndromic reporting system holds promise as a method of ohv surveillance. strengths include near complete chief complaint reporting, rapid availability, and the potential to identify populations and facilities that could benefit from expanded access and preventive education. limitations include the need to gather site-specific facility information (e.g., presence of dental residents, coding practices) to better understand patterns. also, the absence of some important fields in the syndromic system (e.g., insurance coverage, income) limit assessment of the degree to which cost barriers may be driving ohv. fig 1. ohv (def.2) by age, 2009-2011 fig 2. ohv (def.2) by day/time, 2009-2011 keywords chief complaint; surveillance; syndrome definition; oral health acknowledgments the authors would like to thank the bureau of communicable diseases’ data analysis and syndromic surveillance unit for data collection and analytic guidance. references 1. pew center on the states, “a costly dental destination,” accessed august 22, 2012, http://www.pewstates.org/research/reports/a-costlydental-destination-85899379755 2. hong l, ahmed a, mccunniff m, et al. secular trends in hospital emergency department visits for dental care in kansas city, missouri, 2001-2006. public health reports; (march-april 2011) vol 126, no. 2, 210-219. 3. california health care foundation, “emergency department visits for preventable dental conditions in california,” accessed august 22, 2012, http://www.chcf.org/~/media/media%20library%20files/ pdf/e/pdf%20edusedentalconditions.pdf *john p. jasek e-mail: jjasek@health.nyc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e112, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts international collaboration for improved public health emergency preparedness and response in india obaghe edeghere*1, giri shankar1, alastair bartholomew1, srikrishna ramachandra2, vivek singh2, pradeep banandur3, linda parr1, kenny yap1, babatunde olowokure1 and sue ibbotson1 1the health protection agency, birmingham, united kingdom; 2indian institute of public health, hyderabad, india; 3rajarajeswari medical college and hospital, bangalore, india objective this project aimed to contribute to ongoing efforts to improve the capability and capacity to undertake disease surveillance and emergency preparedness and response (epr) activities in india. the main outcome measure was to empower a cadre of trainers through the inter-related streams of training & education to enhance knowledge and skills and the development of collaborative networks in the regions. introduction the international health regulations (ihr) 2005, provides a framework that supports efforts to improve global health security and requires that, member states develop and strengthen systems and capacity for disease surveillance and detection and response to public health threats. to contribute to this global agenda, an international collaborative comprising of personnel from the health protection agency, west midlands, united kingdom (hpa); the indian institute of public health (iiph), hyderabad, andhra pradesh (ap) state, india and the department of community medicine, rajarajeswari medical college and hospital (rrmch), bangalore, karnataka state, india was established with funding from the hpa global health fund to deliver the objectives stated above. methods in 2010, the project partners jointly developed training materials on applied epidemiology & disease surveillance and epr using existing hpa material as the foundation. over a 2 year period, a total of two training courses per year were planned for each of the two locations in india. courses were designed to be delivered through didactic lectures, simulation exercises, workshops and group discussions at the two locations, namely bangalore and hyderabad. the target audience included senior state level programme officers, district medical and health officers, postgraduate students, academic and research staff from community medicine departments and staff from the collaborating institutions. course modules were formally evaluated by participants using structured questionnaires and an external evaluator. debrief sessions were also arranged after each course to review the key lessons and identify areas for improvement. in addition, staff exchanges of up to six weeks duration were planned during which public health specialists from both countries would spend time observing health protection systems/processes in their host country. results during january 2010 to december 2011, a total of seven (n=7) training courses were delivered in bangalore and hyderabad with approximately 231 public health personnel in attendance over the period. participants comprised of 128 personnel representing 74 organisations in 41 districts (22 districts from ap) at the hyderabad location and 103 personnel from 14 organisations (30 districts) at the bangalore location. course participants evaluated the content of the courses favourably with the majority (92%) rating the course modules as excellent or good. external evaluation of the courses was also favourable with several aspects of the course rated as good or excellent. iiph and rrmc continue to deliver the courses and in the state of karnataka, some participants at the epr course were chosen by the health ministry to be part of rapid response teams at district levels. two public health specialists from each of the indian organisations spent six (6) weeks in the united kingdom as part of the planned staff exchanges. the exchanges were assessed to have been successful with important areas for future collaboration identified including proposals to jointly develop an emergency preparedness and response manual for the indian public health audience. conclusions the implementation and maintenance of effective and sustainable systems to ensure global health security relies on a well-trained public health workforce in member states. this innovative collaborative project has gone some way towards meeting its objective of establishing and supporting a cadre of trainers to ensure sustainable improvement in public health capacity and capability in india. after the initial (training) phase of the project that was completely funded by the hpa, the partner organisations in india have worked to sustain and further develop the core objectives of this project. as a further step, course materials developed as part of this project will be used to provide a framework upon which e-learning material and postgraduate modules will be developed in each of these institutions in india. keywords surveillance; training; epr; ihr acknowledgments leanne baker – hpa, uk krishna gayathri iiph, hyderabad *obaghe edeghere e-mail: obaghe.edeghere@hpa.org.uk online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e152, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts early detection of influenza activity using syndromic surveillance in missouri fei wu* and amy kelsey missouri department of health and senior services, jefferson city, mo, usa objective to assess how weekly percent of influenza-like illness (ili) reported via early notification of community-based epidemics (essence) tracked weekly counts of laboratory confirmed influenza cases in five influenza seasons in order to evaluate the early warning potential of ili in essence and improve ongoing influenza surveillance efforts in missouri. introduction syndromic surveillance is used routinely to detect outbreaks of disease earlier than traditional methods due to its ability to automatically acquire data in near real-time. missouri has used emergency department (ed) visits to monitor and track seasonal influenza activity since 2006. methods the missouri essence system utilizes data from 84 hospitals, which represents up to 90 percent of all ed visits occurring in missouri statewide each day. the influenza season is defined as starting during centers for disease control and prevention (cdc) week number 40 (around the first of october) and ending on cdc week 20 of the following year, which is usually at the end of may. a confirmed influenza case is laboratory confirmed by viral culture, rapid diagnostic tests, or a four-fold rise in antibody titer between acute and convalescent serum samples. laboratory results are reported on a weekly basis. to assess the severity of influenza activity, all flu seasons were compared with the 2008-09 season, which experienced the lowest influenza activity based on laboratory data. analysis of variance (anova) was applied for this analysis using statistical analysis software (sas) (version 9.2). the standard essence ili subsyndrome includes ed chief complaints that contain keywords such as “flu”, “flulike”, “influenza” or “fever plus cough” or “fever plus sore throat”. the essence ili weekly percent is the number of ili visits divided by total ed visits. time series of weekly percent of ili in essence were compared to weekly counts of laboratory confirmed influenza cases. spearman correlation coefficients were calculated using sas. the baseline refers to the mean of three flu seasons with low influenza activity (2006-07, 2008-09 and 2010-11 seasons). the threshold was calculated as this baseline plus three standard deviations. the early warning potential of the essence weekly ili percent was evaluated for five consecutive influenza seasons, beginning in 2006. this was accomplished by calculating the time lag between the first essence ili warning versus the first lab confirmed influenza warning. a warning was identified if either lab confirmed case counts or weekly percent of ili crossed over their respective baselines. results for each influenza season evaluated, weekly ili rates reported via essence were significantly correlated with weekly counts of laboratory-confirmed influenza cases (table 1). the baseline of ili activity in essence was 1.8 ili /100 ed visits/week and the threshold was set at 4.1 ili visits per 100 ed visits/week. the essence ili baseline provided, on average, two weeks of advanced warning for seasonal influenza activity. figure 1 shows that two influenza seasons (2007-08 and 2009-10) were more severe than others examined based on the essence percent ili threshold analysis, this result is consistent with the examination of severity of influenza activity based on lab confirmed influenza data (p<0.05). conclusions the significant correlation between ili surveillance in essence and laboratory confirmed influenza cases justifies the use of weekly ili percent in essence to describe seasonal influenza activity. the essence ili baseline and threshold provided advanced warning of influenza and allowed for the classification of influenza severity in the community. table 1. correlation between laboratory confrmed influenza cases and essence ili weekly percent in five influenza seasons, 2006-2011 keywords essence; syndromic surveillance; influenza-like illness (ili); baseline; threshold acknowledgments we thank lesha peterson, rong he and peggy hartman at the missouri department of health and senior services for providing influenza case data. *fei wu e-mail: fei.wu@health.mo.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e37, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts recommendations for syndromic surveillance using inpatient and ambulatory ehr data geraldine johnson1, charles ishikawa2, rebecca zwickl2, maiko minami4, taha kass-hout3 and laura streichert*2 1ny state health dept., albany, ny, usa; 2isds, brighton, ma, usa; 3division of informatics solutions and operations, cdc, atlanta, ga, usa; 4hln consulting, san diego, ca, usa objective to develop national stage 2 meaningful use (muse) recommendations for syndromic surveillance using hospital inpatient and ambulatory clinical care electronic health record (ehr) data. introduction muse will make ehr data increasingly available for public health surveillance. for stage 2, the centers for medicare & medicaid services (cms) regulations will require hospitals and offer an option for eligible professionals to provide electronic syndromic surveillance data to public health. together, these data can strengthen public health surveillance capabilities and population health outcomes (figure 1). to facilitate the adoption and effective use of these data to advance population health, public health priorities and system capabilities must shape standards for data exchange. input from all stakeholders is critical to ensure the feasibility, practicality, and, hence, adoption of any recommendations and data use guidelines. methods isds, in collaboration with the division of informatics solutions and operations at the centers for disease control and prevention (cdc), and hln consulting, convened a multi-stakeholder workgroup of clinicians, technologists, epidemiologists, and public health officials with expertise in syndromic surveillance. recommended muse guidelines were developed by performing an environmental scan of current practice and by using an iterative, expert and community input-driven process. the workgroup developed initial guidelines and then solicited and received feedback from the stakeholder community via interview, e-mail, and structured surveys. stakeholder feedback was analyzed using quantitative and qualitative methods and used to revise the recommendations. results the muse workgroup defined electronic syndromic surveillance (ess) characteristics. specifically, data are characterized by their timeliness, sensitivity rather than specificity, population focus, limited personally identifiable information, and inclusion of all patient encounters within a specific healthcare setting (e.g., emergency department, inpatient, outpatient). based on stakeholder input (n=125) and workgroup expertise, the guidelines identify priority syndromic surveillance uses that can assist with: 1. monitoring population health; 2. informing public health services; and 3. informing interventions, health education, and policy by characterizing the burden of chronic disease and health disparities. similarly, the workgroup identified data elements to support these uses in the hospital inpatient setting and possibly in the ambulatory care setting. they were aligned to previously identified emergency department and urgent care center data elements and stage 1-2 clinical muse objectives. core data elements (required for certification) cover treating facility; patient demographics; subjective and objective clinical findings, including chief complaint, body mass index, smoking history, diagnoses; and outcomes. other data elements were designated as extended (not required for certification) or future (for future consideration). the data elements and their specifications are subject to change based on applicable state and local laws and practices. based on their findings and recommended guidelines detailed in the report, the workgroup also identified community activities and additional investments that would best support public health agencies in using ehr technology with syndromic surveillance methodologies. conclusions the widespread adoption of ehrs, catalyzed by muse, has the potential to improve population health. by identifying and describing potential ess uses of new sources of ehr data and associated data elements with the greatest utility for public health, the recommendations set forth by the isds muse workgroup will serve to facilitate the adoption of muse policy by both healthcare and public health agencies. figure 1: syndromic surveillance data can inform public health functions. keywords ehr; syndromic surveillance; meaningful use; inpatient; ambulatory acknowledgments we thank the isds muse workgroup. this work supported by cdc contract #200-2011-41831. *laura streichert e-mail: lstreichert@syndromic.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e53, 2013 successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 1 ojphi successful public health information system database integration projects: a qualitative study matthew roberts, mph, drph school of public health, university of illinois, chicago, il, usa abstract objective: to explore the most important public health information system database integration project success factors to include: technological, organizational, project-specific, or external. methods: this study involved a cross-case design. cases were identified through literal replication logic and screened through a survey and review of available literature. study participants were interviewed through hour-long sessions steered by a semi-structured guide. survey responses, interview transcripts and available documents were coded and analyzed deductively, and matrices were developed to illustrate relationships. results: leadership among the project’s participants is the most important integration project success factor. this leadership factor manifests in the following ways. executive sponsors champion the initiative. informaticians facilitate communication and system requirement collection. program directors contribute substantive energy to the project and remove obstacles. some other factors also contribute to project success. for example, strong financial management and support promotes project initiation. technological aspects impact the final product’s quality. utilizing formal project management techniques, particularly the agile software development methodology, contributes to successful project resolution by ensuring daily operational effectiveness. discussion: the principal finding illustrates important contributions by project leaders, transcending those of the executive sponsor. other participants, notably informaticians and program directors, substantially contribute to the project’s success. additionally, the agile software development methodology is emerging as a successful approach to project management for these and related projects. conclusion: investing in the leadership and project management skills of database integration project participants could improve the success of future projects. state health department staff considering these projects should carefully select project participants and train them accordingly. keywords: public health information systems, leadership, systems integration, agile, agile methodology abbreviations: public health information systems (phis), child health information system (chis), association of state and territorial health officials (astho), informatics directors peer network (idpn), information technology (it), national electronic disease surveillance system (nedss) correspondence: matthew roberts, university of illinois at chicago, 217-415-7931, matthew.wesley.roberts@gmail.com doi: 10.5210/ojphi.v10i2.9221 mailto:matthew.wesley.roberts@gmail.com successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 2 ojphi copyright ©2018 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. introduction public health information systems (phis) are foundational components of public health infrastructure, providing how health departments collect and maintain data for public health practice [1]. these data support population health services such as controlling outbreaks or designing health promotion programs targeting teen smokers. state governments often establish phis through the state health department, and the systems primarily serve state and local health department data needs [2]. the use of information technology to develop databases is a critical aspect of phis. these databases store public health data, and advances in information technology have improved the ability to develop databases that suit specific program requirements [3]. specialized state public health databases have propagated because of this technical development ease and categorical funding incentives. computing advancements have also readily allowed for the integration of separate databases [4]. database integration often entails the development of a common database for the organization that consolidates operational data from multiple sources [5]. when individual databases are integrated, they collectively create more complete records by piecing together different data elements from different sources. access to complete records can improve coordination of public health activities and reduce costs [6]. the joint council of governmental public health agencies suggest that 1) health departments must integrate databases and 2) these integrated databases must meet information needs at the service delivery level [7]. previous child health information system (chis) database integration activities illustrate the following: the development of a specific phis database integration business case, actions required to successfully execute the project, and prior integration project evaluation efforts [8]. a large measles outbreak in the late 1980s prompted public health and healthcare leaders to evaluate data collection and usage techniques, which led to the initiation of chis database integration efforts. a workgroup identified programs such as immunizations and vital registration as a suitable starting point for the integration projects [9]. evaluation activities included documenting and studying the critical success factors for these integration projects. findings from chis integration studies informed research in related areas [10]. customized program-specific databases have proliferated but often they have not integrated with other databases throughout the health department. many public health program managers have established databases without considering broader database integration. these databases meet the individual program’s data needs, but do not address enterprise information management needs across the organization [11]. silo public health databases result in inefficiencies, such as poor disease control and outbreak response coordination; incomplete service delivery at the local level; and underperforming population health protection measures during public health emergencies [12]. while leaders integrated and evaluated some chis databases, few other successful phis successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 3 ojphi database integration initiatives have been studied. it is not known which phis database integration project factors are most important and how they impact successful public health database integration projects. this study explored factors that most contribute to successful intra-state public health information system database integration projects. technological factors, such as the quality of data within the originating data systems, impact the functionality of the integrated database. organizational factors, such as meaningfully engaged executive leadership and strategic plans, impact the agency’s readiness and commitment to the initiative. project-specific factors, such as effective governance and formal project management techniques, impact the day-to-day administration of the initiative. other factors outside the agency’s direct control, such as data privacy laws or the actions of external stakeholders can also influence the project’s success. the health resources & services administration’s sourcebook lists the nine non-technical integration project elements (factors) [13]. table 1 includes this list in addition to the technical factors. all factors have been grouped into logical domains for this study based upon prior research [14-21]. this manuscript will also describe how agile software development facilitated the daily project management for many of the phis database integration initiatives illustrated in this study. the use of the agile software development methodology in public health practice is poorly understood. agile software development, or simply “agile”, is emerging as a popular software development project management alternative to more traditional approaches such as the widely-used waterfall methodology. the waterfall model entails a prescriptive stage-oriented software development process characterized by exhaustive initial requirement collection and design phases [22]. agile is considered a “lightweight” method for developing software, with principles that focus on intensive collaboration and rapid software iteration versus extensive up-front system requirement documentation and highly-regimented planning [23]. many technology companies utilize agile to rapidly iterate software products and gain a competitive advantage. organizations have utilized agile to create software for healthcare applications [24], and others have modified aspects of the organizational culture by adopting agile practices for managing other types of projects [25]. researchers have studied their experiences in utilizing agile to create and maintain biomedical software, and found the agile approach to be a good fit for these projects [26]. following the failed rollout of healthcare.gov, some departments of the united states federal government immersed themselves in agile methodology with some success [27]. implementing the agile methodology does not come without its risks for failure, but its success factors have been studied [28]. the role of agile in the phis database integration projects identified in this study will be illustrated further. table 1. integration project success factors, grouped organizational domain leadership the project has an executive sponsor, a high level official who advocates for the project, and a champion, someone who is willing to devote a significant effort to see the project succeed. organizational and technical strategy successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 4 ojphi the project has a strategy that takes into consideration local issues such as funding, the political environment, organizational structure, the strengths of the organization, and stakeholder beliefs and values. the selected technical integration approach accounts for internal data governance and data sharing needs, which must conform to state and federal laws and agreements made with stakeholders. project oriented domain project governance the project is guided by a steering committee representing all key stakeholders. the steering committee develops the integration strategy, based on clearly defined business processes. project management the project has formalized management strategies and project management methodologies designed to assure consistent communications, accountability, and resource constraints. technical support and coordination technical information systems support and coordination is organized centrally to assure consistent support and a robust infrastructure capable of maintaining and complying with standards. a business analyst supports implementation. financial support and management the project is adequately funded and has multiple funding sources. evaluation the project has some form of qualitative and/or quantitative monitoring or evaluation that is performed regularly. external domain stakeholder involvement frequent communication with stakeholders and involvement of stakeholders in the integration project throughout the life cycle of the project contributes to its success and credibility. policy support rules, regulations, legislation, and policy advisory or policymaking bodies are supportive or at least neutral to the integration of health information systems. executive sponsors educate policymakers about sensitive issues to garner their support. technical domain source systems databases contain quality program-specific data to be contributed to the database integration project. development technology project managers select a particular technology to be utilized for the integration project including architecture, hardware, database software, data integration engines, user interface, etc. successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 5 ojphi methods a cross-case study design was used for this research. the state health department is the unit of observation, and the database integration projects are the unit of study. case selection the researcher identified cases through literal replication logic, seeking successful state health department intra-state public health information system database integration projects [29]. a threephase screening procedure was utilized, entailing 1) deploying a survey; 2) reviewing successful phis database integration projects; and 3) reputational case selection. the survey targeted state health department informatics staff as members of the association of state and territorial health officials (astho) informatics directors peer network (idpn). the survey was administered to idpn members, and the first phase of screening reduced the candidate list to cases that most closely fit the literal replication design. seven participants responded to the survey, and three met the criteria for additional follow-up. next, the researcher identified and screened cases based on criteria specified through a literature review of frequently documented, successfully completed phis database integration projects. peer reviewed literature, books, and federal agencies have documented these projects, and this literature illustrates best practices and exemplars. in particular, chis database integration research and studies evaluating the environmental public health tracking activities provide substantive insight into successful phis database integration initiatives [30]. the researcher contacted representatives from state health departments presented in these research bodies for inclusion as participants in this study. three cases were selected through this literature review process. finally, one case was identified through reputational case selection referral by the public health informatics institute. through these processes, the researcher retained seven cases that best fit the literal replication design of successful phis database integration projects. the study protocol was reviewed and approved by the university of illinois – chicago institutional review board. survey and interview questions the researcher adapted questions from a previous chis database integration study [31]. the survey questionnaire addressed case demographics and questions that pertain to the technical and project planning domains. the interview guide was piloted with four informaticians from state health departments, and the final version was organized into the domain groupings from table 1. the interview guide asked participants about the agency’s informatics projects and the impact of each domain’s factors on the integration project’s success. procedure the researcher conducted and recorded approximately one-hour semi-structured interviews with state health department informatics directors along with referral follow-up interviews of program directors, bureau chiefs, system administrators, and technical staff. the researcher interviewed twenty-five participants through nineteen interviews (some interviews included two participants) from april to september of 2016. the survey responses were then paired with associated interview transcripts. finally, the researcher obtained from participants and websites copies of pertinent successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 6 ojphi project documentation for review: strategic information technology plans and operational plans for the database integration projects; agency budgets; project meeting minutes; project charters; progress reports; policy documents; and protocols. analyses the analysis included within-case analysis followed by cross-case analysis. the within-case analysis entailed comparing and summarizing survey and interview responses, then contrasting these summaries with the document content analyses. once this was performed for each case, the cases were compared. data were analyzed using a priori theory-based codes with deductive coding: assigning labels to data to summarize the basic topic of a qualitative data passage. the coding began with an initial list of codes based upon pre-existing theory, largely from the chis database integration studies [32]. additional codes emerged inductively. all data analyses were performed using atlas.ti to code and compare thematic survey responses, interview transcripts and the document contents [33]. a common codebook was established serving as the base for all analyses. data display matrices were created to illustrate systemic relationships and the within-case and cross-case synthesis. results study participants discussed state phis database integration projects and the factors that contributed to the projects’ success. supporting documentation substantiated participants’ claims. chart 1 illustrates quote frequencies from the survey responses, interview transcripts, and codes from the document review, and it provides a basis for drawing initial conclusions. chart 1 integration factor quote frequency these counts principally illustrate how much the participants spoke about any of the integration project factors, as specified through the coding process. the technological aspects of the successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 7 ojphi integration projects are discussed most frequently, followed by leadership aspects or cross-cutting departmental projects more generally. leadership emerges as the most important factor after obtaining information about how the factors contribute to the project’s success, participants were asked which factors were the most important and why. these factors are illustrated in table 2, which organizes each interview grouped by case, with columns illustrating the most important project integration factors as reported by the interview participants and an overall conclusion from the researcher’s perspective. leadership aspects of the projects predominate in importance. in particular, participants highlighted the leadership roles of executive sponsors, program directors, and informaticians. financial support and management; project management; and the project’s technology are three other factors that regularly surfaced as important project success factors. table 2. reported most important project success factor and explanation participant by state most important reported factor(s) researcher's explanation state b participant 4 -financial support -organizational strategy -technical support & coordination organizational alignment and accreditation set the stage. executive staff serve as project champions. informatics business analysts make a difference. demonstrating value secures flexible funding. participant 5 -financial support -informatics leader dedicated funding is crucial. informaticists bridge communication gaps. participants 6 & 7 -financial support -technical support & coordination project completely stalled when the funding temporarily vanished. well-defined system requirements propel the project. participant 8 -leadership, executive* -financial support executive champions play a critical role. funding is crucial, and can be frustrating. participant 9 -leadership, executive* -financial support executive champions and project funding are crucial. state f participants 19 & 20 -leadership, program* -informatician leader team dynamics and personalities make or break the project. program-level leadership, not executive support, makes the most difference. participants 21 & 22 -leadership, program* -informatician leader -technology interaction between the tech team and business analyst/informatician is critical. division-level (not executive) leadership facilitates success. a competent and capable information technology team is key. successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 8 ojphi -technical support & coordination state a participant 1 -organizational strategy -informatician leader -policy development organizational changes linked to strategic planning can have a big impact. informatician leaders have an enterprise approach. effective policy facilitates technical decisions. participants 2 & 3 -technology -project management source data matters. dedicate a tech person to the project. strong project management includes subject matter experts. state e participant 16 -leadership, executive* -informatician leader engaged executive leadership provide vision and support, and can facilitate practical changes, such as the shift to agile project management. informatics staff lead the projects. participant 17 -project management -leadership, program* moving to agile from waterfall profoundly impacted the project's success and augmented team synergy. program directors provide substantive leadership. participant 18 -leadership, program* -financial support sustained program director leadership was crucial. agency timing was right--the will emerged. federal grants were critical. state g participant 23 -leadership, program* relationships are important. program director leadership remove obstacles and ensure team synergy. participant 24 -leadership, program* -informatician leader teamwork is most critical. the involved programs have the same program director and they frequently collaborate. lead informatician is instrumental in making it a success. state d participants 14 & 15 -financial support -leadership, executive and program* federal funding has been critical. the first phase of the projects directly involves senior leadership, whereas latter phases require program leaders to step up. state c participant 10 -financial support -informatics leader -leadership, executive* federal funding for a related initiative was leveraged for this project. informatician and it tenacity are critical. senior-level support and interest are required. participant 11 -informatics leader team dynamics achieve the outcomes. informatics capacity must be carefully maintained or it can erode. successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 9 ojphi participants 12 & 13 -technology -leadership, program* standards makes much of the work possible. program directors facilitate project success. funding plays an important prioritization role. data sharing agreements are necessary. *illustrates the distinction between executive-level and program-level leadership. further exploration into the leadership dimension illustrated important nuances. participants agreed upon the contributions of the informatics staff involved in the initiatives. informaticians seemed to facilitate the collection of system requirements, translated and communicated needs across project participants and to project sponsors, and developed collaborative team dynamics. however, the contributions of executive leadership and that of program directors were less universally-acknowledged. some participants attributed project success to the involvement of meaningfully-engaged executive sponsors, whereas others suggested success was due to the regular involvement of program directors directly impacted by the project. agile emerges as a promising project management technique project management was indicated by many participants as an important success factor for these initiatives. table 3 illustrates the project management technique used for each case’s project and a summary of the technique’s impact on the project’s success. all but one case referenced agile project management in some way, and the participants appeared to express favorable opinions about the role the agile project management methodology played in the project’s success. table 3. project management techniques by case case project management methodology project management impact on project’s success state a agile with scrum specifically scrum techniques facilitate project management. agency recently moved to agile model. “in terms of the meetings and stuff go, we are using the scrum process here, an agile scrum process for development, which was also a big change. we used to use waterfall… but it’s proven that it’s working pretty well, since we switched a couple of years ago.” state b none, although vendor possibly utilized agile minimal impact from participants’ perspective. “i think they used the agile method with short sprints.” state c agile agile methodology referenced by one participant but not by others. “we do agile development. so pretty standardized as far as project management, planning and the reporting is concerned.” state d agile regular, sustained activities move the project forward. successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 10 ojphi “[the nedss] uses the agile development approach. all the local users’ representatives really committed a lot of time to do it.” state e agile moved to agile from waterfall methodology and this change has had a substantive impact, including leading other areas of the agency to adopt the methodology. “we also have moved from a waterfall method for project management to an agile methodology. it has made all of the difference in the world; i cannot tell you what a difference it has made. it’s been incredible.” “i think that if we hadn’t had agile, we still wouldn't have a system up. we would have trashed the build and still wouldn’t have something.” state f waterfall for most projects but agile for one consider agile to be the better method but not used consistently across the organization. “and agile to me was superior and definitely what we should implement here.” state g none minimal impact from participants’ perspective. the participants described that by utilizing agile, the program staff, informatics personnel, technological developers, and others involved in the project closely collaborated in the development of the integrated database, producing a better product and overall experience than that through traditional software development techniques. one case’s participants in particular, state e, stated that the shift to agile from the waterfall methodology introduced a profound cultural shift within the agency that transcended phis database integration and general information technology project management. other areas of the agency began applying agile methodology to other projects based upon the success identified in its use with the phis database integration projects. participant 16 described this profound shift: “since that time we don’t do anything but agile. what’s really cool is some of our business side—our service areas—want to start using agile with their staff, because it holds people accountable. you have to stand up and say ‘this is what i did yesterday, and this is what i’m going to do today.’ everybody gets to hear it; everybody has to be accountable. it builds that team that you just don’t always see with things like that. it was a profound difference, i’ll tell ya.” this shift to agile methodology had substantively changed the project management experience for some of the study’s participants. participant 17 from state e suggested that the utilization of the agile methodology was the most important success factor for the project: “i definitely think it’s the agile process in and of itself. it helped the project move forward. even when we had a roadblock it’s not like everything just stopped…it created this wonderful team atmosphere where everybody knows we’re working for this same end goal.“ successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 11 ojphi “switching to agile made a huge difference, and i would recommend it for any process.” “so it’s a very interactive, engaged process. it’s incredible, i’ll tell ya. i’ve been amazed at the differences—-the speed at which a project gets done. all of that front-end time is lost.” agile clearly changed the way the health department conducted business, and positively impacted many of the integration projects described in this study. consistency across cases the case summary table (table 4) illustrates cross-case comparisons and distinct features of each. the participants’ remarks from each case seem to consistently reflect across the spectrum of cases. funding is cited as a project catalyst, and leadership involvement across multiple levels of the organization ensures project success in various ways. technological factors such as the quality and structure of source data, ensuring standards are employed, and maintaining data warehousing expertise impact the development of the integrated database. effective project management facilitates project success, and agile is regularly referenced as a useful method. however, important differences surface when participants describe the contributions of the executive leaders compared with those of program directors. as alluded to in table 2, some cases evenly highlight the contributions of both groups, whereas other cases are characterized by substantive involvement of either executive leaders or program directors, but not both. table 4. case summary table state summary state a strategic planning and policy development set the project context. the informatician plays a critical role by fully engaging team members. the quality of the source data impacts development progress. state b executive leaders align resources and seed funding. informaticians collect thorough business requirements. prior strategic planning that addressed information management principles seems to have had a lasting positive effect. state c leadership by the program staff and informatician ensure functional team dynamics. technological standards facilitate other programs’ integration efforts. executive support and interest bolster project activities. funding is critical. state d executive leadership set the project vision and initial activities, and strong program and bureau leaders are required for project sustainment. funding is essential. state e program and executive-level leadership both impact the project. an agency-wide shift to agile project management changed the organizational culture and facilitated success. informatics staff lead these initiatives. funding was crucial. successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 12 ojphi state f program-level leadership and informatics leaders promote healthy relationships and team dynamics. information technology team member permanence ensures continuity. state g program directors and informaticians ensure success by fostering functional team dynamics and relationships. discussion principal findings the study’s principal findings illustrate the complex involvement in phis database integration project leadership beyond the role of the executive leaders. much is known about how executive leaders contribute to project success through their sponsorship and support. this study suggests that other project participants, notably informaticians and program directors, substantially contribute to the project’s success. while executive involvement might be critical for initiating the project, program directors ensure project staff remain engaged, and informaticians provide a crucial role in facilitating project conversations across diverse participants. additionally, the agile software development methodology is emerging as a successful approach to project management for these and related projects. some participants claim adopting this approach introduced a dramatic shift in how the integration projects progressed, and one suggested this was the main reason that site’s project succeeded. agile improves project accountability and team member involvement and interaction, while speeding the deployment of useful software. implications this study has three primary implications. first, developing the leadership skills of informaticians, relevant program directors, and executive leaders may promote the success of these and related initiatives. since these projects require informatics savviness, these individuals may benefit from informatics training more generally, and phis database integration training specifically. secondly, project financing challenges are not new to public health departments, and this aspect seems to impact phis database integration project success, especially the launching of these initiatives. federal programs have funded these efforts in the past, and future funding could facilitate their initiation. finally, employing formal project management techniques might ensure the project runs smoothly. investing in agile methodology training and enabling its use could be an effective approach to ensuring the project is properly managed. limitations this study has three principal limitations. first, cases purposefully recruited represent an exemplary and small subset of all state public health departments. therefore, the study’s results should not be interpreted as representative of all state health departments. secondly, the data are based on survey responses, interviews, and a document review. participant responses may be affected by subjectivity, and undiscovered documentation may suggest alternative conclusions. the data had not been triangulated with onsite visits and additional observations to corroborate findings. thirdly, a single researcher performed the data collection, coding, and analysis. inclusion successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 13 ojphi of another researcher could confirm codes and findings. despite these limitations, the study’s findings provide useful insight into integration project success. more research in this area is needed to further understand this topic. conclusion this study improves the understanding of the most important public health information system database integration project success factors. public health database integration needs persist, and stakeholders may use these findings to improve the likelihood of future project success. acknowledgments i would like to acknowledge the following individuals: my committee chair and advisor, dr. patrick lenihan, and committee members dr. eve pinsker, dr. seth foldy, dr. edward mensah, and dr. kee chan. i also thank the study’s participants for their insight and wisdom. financial disclosure no financial disclosures competing interests no competing interests references 1. ammenwerth e, graber s, herrmann g, bürkle t, könig j. 2003. evaluation of health information systems—problems and challenges. int j med inform. 71, 125-35. pubmed https://doi.org/10.1016/s1386-5056(03)00131-x 2. yasnoff wa, o’carroll pw, koo d, linkins rw, kilbourne em. 2000. public health informatics: improving and transforming public ehealth in the information age. j public health manag pract. 6(6), 67-75. pubmed https://doi.org/10.1097/00124784-200006060-00010 3. magruder c, burke m, hann ne, ludovic ja. 2005. using information technology to improve the public health system. j public health manag pract. 11(2), 123-30. pubmed https://doi.org/10.1097/00124784-200503000-00005 4. arzt nh. evolution of public health information systems: enterprise-wide approaches. san diego: hln consulting; 2007. 5. mannino m, hong sn, choi ij. 2008. efficiency evaluation of data warehouse operations. decis support syst. 44, 883-98. https://doi.org/10.1016/j.dss.2007.10.011 6. foldy s, grannis s, ross d, smith t. 2014. a ride in the time machine: information management capabilities health departments will need. am j public health. 104(9), 1592-600. pubmed https://doi.org/10.2105/ajph.2014.301956 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=14519405&dopt=abstract https://doi.org/10.1016/s1386-5056(03)00131-x https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18019962&dopt=abstract https://doi.org/10.1097/00124784-200006060-00010 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=15711442&dopt=abstract https://doi.org/10.1097/00124784-200503000-00005 https://doi.org/10.1016/j.dss.2007.10.011 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25033122&dopt=abstract https://doi.org/10.2105/ajph.2014.301956 successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 14 ojphi 7. lumpkin j, atkinson d, biery r, cundiff d, mcglothlin m, et al. 1995. the development of integrated public health information systems: a statement by the joint council of governmental public health agencies. j public health manag pract. 1(4), 55-59. pubmed 8 linzer ds, lloyd-puryear ma, mann m, kogan md. 2004. evolution of a child health profile initiative. j public health manag pract. november(suppl):s16-s23. 9 hinman ar, delton a, diehn tn, eichwald j, heberer j, hoyle t, king p, kossack re, williams dc, zimmerman a. 2004. principles and core functions of integrated child health information systems. j public health manag pract. november (suppl):s52-s56. 10 saarlas kn, hinman ar, ross da, watson wc jr, wild el, hastings tm, richmond pa. 2004. all kids count 1991–2004: developing information systems to improve child health and the delivery of immunizations and preventive services. j public health manag pract. november(suppl),s3–s15. 11. davenport dh. mission critical: realizing the promise of enterprise systems. boston, massachusetts: harvard business school press; 2000. 12. hasbrouck l. 2016. strengthening local health department informatics capacity through advocacy, education, and workforce development. j public health manag pract. 22(6) (supp), s3-5. pubmed https://doi.org/10.1097/phh.0000000000000475 13 wild el, fehrenbach sn. 2004. assessing organizational readiness and capacity for developing an integrated child health information system. j public health manag pract. november(suppl):s48-s51. 14 fehrenbach sn, kelly jcr, vu c. 2004. integration of child health information systems: current state and local health department efforts. j public health manag pract. november(suppl):s30-s35. 15. hwang hg, ku cy, yen dc, cheng cc. 2004. critical factors influencing the adoption of data warehouse technology: a study of the banking industry in taiwan. decis support syst. 37, 1-21. https://doi.org/10.1016/s0167-9236(02)00191-4 16. wixom bh, watson hj. 2001. an empirical investigation of the factors affecting data warehousing success. manage inf syst q. 25(1), 17-41. https://doi.org/10.2307/3250957 17. joshi k, curtis m. 1999. issues in building a successful data warehouse. information strategy: the executive’s journal. military & government collection, ipswich, ma. 15(2), 28. accessed july 19, 2015. 18. watson hj, fuller c, ariyachandra t. 2004. data warehouse governance: best practices at blue cross and blue shield of north carolina. decis support syst. 38, 435-50. https://doi.org/10.1016/j.dss.2003.06.001 19. ramamurthy kr, sen a, sinha ap. 2008. an empirical investigation of the key determinants of data warehouse adoption. decis support syst. 44, 817-41. https://doi.org/10.1016/j.dss.2007.10.006 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=10186643&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27684615&dopt=abstract https://doi.org/10.1097/phh.0000000000000475 https://doi.org/10.1016/s0167-9236(02)00191-4 https://doi.org/10.2307/3250957 https://doi.org/10.1016/j.dss.2003.06.001 https://doi.org/10.1016/j.dss.2007.10.006 successful public health information system database integration projects: a qualitative study online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e207, 2018 15 ojphi 20. markus ml. 1983. power, politics, and mis implementation. commun acm. 26(6), 430-44. https://doi.org/10.1145/358141.358148 21. rizi s, roudsari a. 2013. development of a public health reporting data warehouse: lessons learned. medinfo. •••, 861-65. pubmed 22. boehm bw. 1988. a spiral model of software development and enhancement. computer. 21(5), 61-72. https://doi.org/10.1109/2.59 23. meyer b. agile!: the good, the hype and the ugly. zurich, switzerland: springer international publishing switzerland; 2014. 24. raghu a, praveen d, peiris d, tarassenko l, clifford g. 2015. engineering a mobile health tool for resource-poor settings to assess and manage cardiovascular disease risk: smarthealth study. bmc med inform decis mak. 15, 36. pubmed https://doi.org/10.1186/s12911-015-0148-4 25. kitzmiller r, hunt e, sproat sb. 2006. “agility” moves from software development to healthcare project management. comput inform nurs. 24(2), 75-82. pubmed https://doi.org/10.1097/00024665-200603000-00005 26. kane dw, hohman mm, cerami eg, mccormick m, kuhlmman kf, et al. 2006. agile methods in biomedical software development: a multi-site experience report. bmc bioinformatics. 7, 273. pubmed https://doi.org/10.1186/1471-2105-7-273 27. christy a. 2016. government goes agile. stanf soc innov rev. (spring), 13-14. 28. misra sc, kumar v, kumar u. 2009. identifying some important success factors in adopting agile software development practices. j syst softw. 82, 1869-90. https://doi.org/10.1016/j.jss.2009.05.052 29. yin rk. case study research: design and methods—4th ed. thousand oaks, california: sage publications, inc.; 2009. 30. qualters jr, strosnider hm, bell r. 2015. data to action: using environmental public health tracking to inform decision making. j public health manag pract. 21(2) (supp), s12-22. pubmed https://doi.org/10.1097/phh.0000000000000175 31. bara d, mcphillips-tangum c, wild el, mann my. 2009. integrating child health information systems in public health agencies. j public health manag pract. 15(6), 451-58. pubmed https://doi.org/10.1097/phh.0b013e3181abbec8 32. maxwell ja. qualitative research design: an interactive approach-3rd ed. thousand oaks, california: sage publications, inc.; 2013. 33. miles mb, huberman am, saldaña j. qualitative data analysis: a methods sourcebook—3rd ed. thousand oaks, california: sage publications, inc.; 2014. https://doi.org/10.1145/358141.358148 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23920680&dopt=abstract https://doi.org/10.1109/2.59 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25924825&dopt=abstract https://doi.org/10.1186/s12911-015-0148-4 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16554690&dopt=abstract https://doi.org/10.1097/00024665-200603000-00005 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16734914&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16734914&dopt=abstract https://doi.org/10.1186/1471-2105-7-273 https://doi.org/10.1016/j.jss.2009.05.052 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25621441&dopt=abstract https://doi.org/10.1097/phh.0000000000000175 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19823148&dopt=abstract https://doi.org/10.1097/phh.0b013e3181abbec8 successful public health information system database integration projects: a qualitative study abstract introduction methods survey and interview questions procedure analyses results leadership emerges as the most important factor agile emerges as a promising project management technique consistency across cases discussion principal findings implications limitations conclusion acknowledgments financial disclosure competing interests references evaluating multi-purpose syndromic surveillance systems – a complex problem 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi evaluating multi-purpose syndromic surveillance systems – a complex problem roger morbey1*, gillian smith1, isabel oliver2, obaghe edeghere3, iain lake4, richard pebody5, dan todkill3, noel mccarthy6, and alex j. elliot1 1 real-time syndromic surveillance team, field service, national infection service, public health england, birmingham b2 4bh, united kingdom; 2 field service, national infection service, public health england, bristol bs1 6eh, united kingdom; 3 field epidemiology west midlands, field service, national infection service, public health england, birmingham b2 4bh, united kingdom; 4 school of environmental sciences, university of east anglia, norwich, nr4 7tj, united kingdom; 5 influenza and other respiratory virus section, immunisation and countermeasures division, national infection service, public health england, london nw9 5eq, united kingdom; 6 warwick medical school, division of health sciences, university of warwick, cv4 7al, united kingdom abstract surveillance systems need to be evaluated to understand what the system can or cannot detect. the measures commonly used to quantify detection capabilities are sensitivity, positive predictive value and timeliness. however, the practical application of these measures to multi-purpose syndromic surveillance services is complex. specifically, it is very difficult to link definitive lists of what the service is intended to detect and what was detected. first, we discuss issues arising from a multi-purpose system, which is designed to detect a wide range of health threats, and where individual indicators, e.g. ‘fever’, are also multi-purpose. secondly, we discuss different methods of defining what can be detected, including historical events and simulations. finally, we consider the additional complexity of evaluating a service which incorporates human decision-making alongside an automated detection algorithm. understanding the complexities involved in evaluating multi-purpose systems helps design appropriate methods to describe their detection capabilities. keywords: public health, epidemiology, surveillance, outbreaks abbreviations: positive predictive value (ppv) * correspondence: roger.morbey@phe.gov.uk doi: 10.5210/ojphi.v13i3.10818 copyright ©2021 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. mailto:roger.morbey@phe.gov.uk evaluating multi-purpose syndromic surveillance systems – a complex problem 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi introduction syndromic surveillance syndromic surveillance involves monitoring health care data on symptoms, signs and diagnoses to provide information for public health action [1]. syndromic surveillance is often multi-purpose, using many different syndromes or clinical indicators to monitor different conditions and events of public health interest. public health organisations may operate a syndromic surveillance ‘service’ that includes several ‘systems’, with each ‘system’ using data from one source, e.g. emergency departments, family doctors or ambulances. an on-going syndromic surveillance service is more than a series of data processing steps, it involves analysis, interpretation, reporting and enabling decision-making for appropriate action. it also requires a cycle of continuous improvement, with development of novel approaches and their subsequent application into the service. when interpreting information from syndromic surveillance systems, public health practitioners, e.g. epidemiologists or incident directors, need to understand the capabilities of those systems to support decision making and choice of actions. incident directors and other users want answers to apparently simple questions such as: “how many cases of cryptosporidiosis need to occur before your system detects an outbreak in this area?”; or “how much early warning can you provide of increases in seasonal influenza?” evaluating syndromic surveillance existing evidence base the centre for disease control and prevention (cdc) in the united states of america created a framework for evaluating a syndromic surveillance service [2]. this framework has been widely adopted and used to evaluate both syndromic and traditional non-syndromic surveillance. the framework has been applied to evaluate services both quantitatively and qualitatively [3,4]. furthermore, a wide range of statistical aberration detection algorithms have been applied to syndromic surveillance, to identify unusual exceedances that might indicate a threat to public health [5-7]. consequently, much of the published research on quantifying the public health benefit of syndromic surveillance focuses on the use of the statistical algorithms. however, retrospectively identifying that an algorithm can detect outbreaks does not inform whether appropriate public health action was taken by the syndromic surveillance service or the impact on public health [8]. it is also important to evaluate the service’s decision-making and operational processes [9]. surveillance does not end with the generation of a statistical alarm. following an alarm there will be decisions about the importance of the alarm, possibly further epidemiological investigations and analysis to summarise findings in key messages, and finally there will decisions about appropriate public health action. therefore, further work is also needed to evaluate these later stages of syndromic surveillance as well as the detection algorithms. similarly, published evaluations of syndromic systems often focus on just one disease or syndrome [10], whereas syndromic surveillance services are often multi-purpose [5]. importantly, syndromic surveillance has the potential to detect future unknown hazards, for instance symptoms resulting from a newly emerging disease, such as covid-19, for which laboratory tests may not yet be available [11]. therefore, there is a gap in our understanding of the detection capabilities of multi-purpose syndromic surveillance services because services are usually only evaluated as if they have a single purpose and only in terms of the ability to generate statistical alarms. evaluating multi-purpose syndromic surveillance systems – a complex problem 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi quantifying the detection capabilities of a multi-purpose service a complex problem ideally, simple clear quantitative measures should be provided to describe a multi-purpose service’s detection capabilities. however, published quantitative estimates for detection capabilities have usually been restricted to single diseases or to the automated part of a service. for example, it is much easier to deliver estimates structured as “the algorithm had a sensitivity of 98% and a specificity of 84% for simulated influenza outbreaks” rather than “this syndromic service resulted in appropriate action 85% of the time, with 20% of actions subsequently found to be unnecessary”. this research focus may be because quantifying the detection capabilities of a multi-purpose syndromic service is not as straightforward as it might initially appear. in fact, this is not just a complicated problem but a complex one. a complicated problem might be large and require considerable resources but can be answered by a single rule-based process, whereas a complex problem requires a range of context-specific methods to obtain answers. similar issues of complexity have been found in evaluating public health interventions [12]. here, we provide a perspective paper on the complexities involved in providing meaningful answers for what can and cannot be detected by a multi-purpose syndromic surveillance service. thus, we aim to suggest a way forward in tackling this complex problem, which can be adopted by other organisations and countries coordinating a multi-purpose syndromic surveillance service. measures for quantifying detection – laboratory tests analogy syndromic surveillance systems are often used alongside and complement traditional surveillance systems such as those based on laboratory testing. therefore, we use laboratory tests as an example to describe how detection capabilities can be quantified. then, by analogy we discuss what is required to quantify the detection capabilities of syndromic systems. quantifying laboratory tests – a ‘simple’ example a laboratory test needs to be able to identify disease rapidly with few ‘false alarms’ [13]. therefore, evaluation measures must include: a measure for how likely the test is to detect disease; a measure for how likely it is to create false alarms; and for how quickly it will detect disease. firstly, sensitivity (also called recall) can be defined as the proportion of patients with disease correctly identified by a positive test. secondly, false alarms can be quantified using, specificity or positive predictive value (ppv; also, called precision). specificity can be defined as the proportion of tested patients without a disease with a negative test result, and ppv by the proportion of positive tests that come from patients with the disease. finally, timeliness can be defined as the time between a sample being taken and the laboratory report being available. calculating these quantitative measures for a laboratory test requires a list of patients, with a variable for whether the disease or condition is present, and a linked list of samples, with a variable for whether the laboratory test was positive for the disease or condition (figure 1). evaluating multi-purpose syndromic surveillance systems – a complex problem 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi sensitivity = 𝑪𝒐𝒓𝒓𝒆𝒄𝒕 𝒅𝒆𝒕𝒆𝒄𝒕𝒊𝒐𝒏𝒔 𝑷𝒂𝒕𝒊𝒆𝒏𝒕𝒔 𝒘𝒊𝒕𝒉 𝒅𝒊𝒔𝒆𝒂𝒔𝒆 specificity = 𝑪𝒐𝒓𝒓𝒆𝒄𝒕 𝒓𝒆𝒂𝒔𝒔𝒖𝒓𝒂𝒏𝒄𝒆𝒔 𝑷𝒂𝒕𝒊𝒆𝒏𝒕𝒔 𝒘𝒊𝒕𝒉 𝒏𝒐 𝒅𝒊𝒔𝒆𝒂𝒔𝒆 ppv = 𝑪𝒐𝒓𝒓𝒆𝒄𝒕 𝒅𝒆𝒕𝒆𝒄𝒕𝒊𝒐𝒏𝒔 𝑷𝒐𝒔𝒊𝒕𝒊𝒗𝒆 𝒕𝒆𝒔𝒕 𝒓𝒆𝒔𝒖𝒍𝒕𝒔 did the patient have the disease? yes no was the laboratory test positive? yes correct detection (true positive) false warning (false positive) no fail to detect (false negative) correct reassurance (true negative) figure 1. results matrix for evaluating the sensitivity and specificity of a single laboratory test quantifying syndromic surveillance – a ‘complex’ example by analogy, it should be possible to create the same quantitative measures i.e. the sensitivity, specificity, ppv and timeliness of a syndromic surveillance service (figure 2). however, instead of comparing a list of patients and test results, we need a list of events we want to detect and a linked list of detections made by the service (throughout this paper, we will use the term ‘event’ to cover all the different public health threats a service aims to detect, including outbreaks with different aetiologies, public health incidents and the impact of environmental exposures etc., figure 3). sensitivity = 𝑪𝒐𝒓𝒓𝒆𝒄𝒕 𝒅𝒆𝒕𝒆𝒄𝒕𝒊𝒐𝒏𝒔 𝑬𝒗𝒆𝒏𝒕𝒔 𝒐𝒄𝒄𝒖𝒓𝒊𝒏𝒈 specificity = 𝑪𝒐𝒓𝒓𝒆𝒄𝒕 𝒓𝒆𝒂𝒔𝒔𝒖𝒓𝒂𝒏𝒄𝒆𝒔 𝑵𝒐 𝒆𝒗𝒆𝒏𝒕𝒔 𝒐𝒄𝒄𝒖𝒓𝒓𝒊𝒏𝒈 ppv = 𝑪𝒐𝒓𝒓𝒆𝒄𝒕 𝒅𝒆𝒕𝒆𝒄𝒕𝒊𝒐𝒏𝒔 𝑨𝒍𝒍 𝒅𝒆𝒕𝒆𝒄𝒕𝒊𝒐𝒏𝒔 𝒓𝒆𝒑𝒐𝒓𝒕𝒆𝒅 did an event occur? yes no did the syndromic service report detection? yes correct detection (true positive) false warning (false positive) no fail to detect (false negative) correct reassurance (true negative) figure 2. results matrix for evaluating a multi-purpose syndromic surveillance service. in theory, given a linked list of events to be detected and a list of detections reported by a syndromic service, we can quantify the detection capabilities of the service. however, in practice, creating definitive linked lists of events and detections is complex. evaluating multi-purpose syndromic surveillance systems – a complex problem 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi what do we want to detect with syndromic surveillance? multi-purpose surveillance syndromic surveillance was originated to provide population-level surveillance for early warning for bioterrorism threats but it has subsequently been used for early warning of other events and is increasingly used for reassurance of the lack of adverse health impact in a specific context, or for situational awareness after a known exposure [1,14]. a multi-purpose syndromic surveillance service may have multiple objectives [2, 8, 10]: • early warning of unexpected events, e.g. bioterrorism, emerging new diseases, outbreaks; • early warning of aberrant trends by monitoring endemic or seasonal diseases, e.g. scarlet fever or seasonal influenza; • reassurance and monitoring during mass gatherings e.g. olympic and paralympic games; • situational awareness during pre-identified outbreaks or environmental incidents, e.g. covid-19, an influenza pandemic or heat wave; therefore, a multi-purpose syndromic surveillance service will need to detect a wide range of events, reflecting potential threats to public health, including infectious disease, environmental impacts and mass gatherings (figure 3). purpose objective event type c o m p re h e n siv e p o p u la tio n su rv e illa n c e provide early-warning of unexpected threats to public health epidemic of severe respiratory illness, e.g. sars, covid-19 cryptosporidium outbreaks norovirus outbreaks food poisoning outbreaks bioterrorism monitor trends to give early warning of atypical activity seasonal influenza seasonal respiratory syncytial virus scarlet fever “back to school” asthma [1] measles mumps rubella evaluating multi-purpose syndromic surveillance systems – a complex problem 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi pertussis hay fever insect bites t a r g e te d su b -g r o u p su rv e illa n c e monitoring of specific context to provide reassurance or early warning of impact on health vaccine impact volcanic ash cloud floods large industrial fires s itu a tio n a l a w a re n e ss measuring impact of known exposure out of season pandemic influenza extreme cold weather heat waves “thunderstorm asthma” [2] impact of air pollution impact of water contamination figure 3. types of events that a multi-purpose syndromic surveillance service aims to detect. compiling a list of events to be detected through multi-purpose surveillance is complex because different types of events are defined in different ways. for example, point-source outbreaks might have a clear start and end date, whilst propagated or seasonal epidemics cannot be clearly defined in this way [8]. similarly, how suspected events are validated will vary by type. for infectious diseases, laboratory reports provide a ‘gold-standard’ for incidence, however, independent data may not be available for other types of events, e.g. increase in hay fever reports. for some types of events, e.g. extreme weather or mass-gatherings, it may be easy to validate exposure but less obvious how to independently validate impact on the population’s health. consequently, we may be able to create a list of events which have been detected by other surveillance systems (but not those which haven’t), but not be certain about the timing and size of any public health impacts that the syndromic service needs to detect. obtaining historical examples it is important that syndromic services are evaluated across the full range of event types and different sizes of event [17, 18]. however, for some types of event there may be no historical data available or only a limited range of outbreak sizes, locations etc. [8]. therefore, synthetic simulated data are often used to evaluate syndromic systems [19]. there are advantages and disadvantages for using real historical events or using synthetic events, historical events may be rare whilst synthetic events may be unrealistic [20]. the main disadvantage of using synthetic events is that they require modelling assumptions, for example, healthcare seeking behaviours for a range of diseases need to be estimated from other research, which is not straightforward [21]. a commonly used approach is to ‘inject’ synthetic simulations of events into ‘real’ historic syndromic data [5]. furthermore, real scaled events can be injected to reduce modelling assumptions about the relationship between outbreak size and syndromic indicators [17, 22-24]. however, results will still depend upon assumptions about the lag between exposure, symptom onset and whether a person presents to health care. evaluating multi-purpose syndromic surveillance systems – a complex problem 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi completeness of event lists to evaluate a syndromic service, the list of events to be detected must be comprehensive and exclusive (figure 3). furthermore, to estimate specificity or ppv, an identified period without such events is also needed. however, even for event types where numerous independently verifiable outbreaks are available, it may be impossible to guarantee that all events have been identified. it is perfectly plausible that syndromic data contain unverified events, for example, increases in respiratory illness have been observed in autumn that cannot be explained by comparison with laboratory data [20]. these unverified outbreaks within baseline syndromic data can result in lower specificity and ppv estimates [8, 14]. figure 4 summarizes the complexities around defining what needs to be detected by syndromic surveillance, as discussed above. reason definition is complex example little or no historical data may be available bioterrorism, newly emerging diseases simulated data is sensitive to modelling assumptions patients’ health-seeking behaviour is difficult to predict event may not be routinely monitored by nonsyndromic systems seasonal hay fever exposure may be clearly defined but impact on public health is still uncertain heat waves laboratory ‘gold-standard’ for independent verification may not exist newly emerging pathogen precise start and end date of exposure might be uncertain seasonal influenza events causing similar symptoms may occur at the same time air pollution and seasonal respiratory illness control period without events may be unavailable syndromic baseline data is rarely zero figure 4. reasons why defining ‘events’ to be detected by syndromic surveillance are complex. defining detection with syndromic surveillance whilst it is relatively straightforward to define the detection parameters for statistical algorithms [25], it becomes more complex when we consider the whole syndromic surveillance service. firstly, we need to consider how the service reports detection, which may depend on its ‘surveillance objective’. secondly, we need to decide how to link detection to events in the context of multi-purpose syndromic surveillance. objectives for a syndromic surveillance service the objective that a syndromic service is fulfilling will affect both the definition of detection and its ability to detect events. for example, when acting as an early warning system a evaluating multi-purpose syndromic surveillance systems – a complex problem ojphi syndromic service may define detection as alerting the appropriate authorities prior to any other surveillance system. successful early warning depends on a service’s routine surveillance practices and reporting arrangements. by contrast, when providing situational awareness during a known event, the multi-purpose service can focus on a geographical area and subset of syndromic indicators, which will increase the probability of detecting an impact. also, when providing situational awareness, the service may define detection as identifying small changes in trends, which would not have triggered an early warning response to a hitherto unknown event. similarly, a service that routinely monitors seasonal diseases (e.g. influenza) may have specifically developed thresholds that are more sensitive than those that warn of undefined new threats [26]. finally, the objective of a syndromic service may change when an event becomes publicly known through media reports, e.g. covid-19. moreover, syndromic indicators may be affected by changes in patient health-seeking behaviour because of increased awareness after an event [8, 10, 27], or changes in government advice e.g. during a lock-down. in summary, creating a list of detections requires consideration of whether the event was expected and the service’s objective at the time of detection. multi-purpose syndromic indicators the ability to link what is detected by syndromic surveillance to specific events is further complicated because many syndromic indicators are multi-purpose. whilst some syndromic indicators are very specific (e.g. bloody diarrhoea) others (e.g. gastrointestinal) are designed to have a high sensitivity but low specificity to maximise the chance of detecting events or to ensure that new emerging threats, such as covid-19, are captured [3, 4, 28]. these broad syndromic indicators may detect a range of different types of events. for example, generic respiratory indicators (e.g. cough or difficulty breathing) have been found to be associated with changing trends in laboratory reports for several different respiratory pathogens [20, 29-30] as well as seasonal allergies [31]. consequently, a syndromic service will often detect an increasing trend but not be able to link it to a specific event or individual organism, without further context. however, the ability to link detection to events may also depend on the objective of the surveillance system. for example, during a known laboratory-confirmed measles outbreak, a syndromic service may use a general indicator, e.g. rash, for situational awareness, which would not be considered as an effective early warning indicator for unknown measles outbreaks [10]. furthermore, when laboratory data are not available to verify causal pathogens, syndromic indicators or combinations of symptoms may be used to suggest probable causes of outbreaks [3, 32], particularly for multi-system surveillance [20]. finally, during a pandemic of an emerging disease like covid-19, new processes or diagnostic codes may be introduced which have an impact on existing syndromic indicators. discussion much of the published research evaluating syndromic surveillance focuses either on just one type of event or on the detection capabilities of statistical algorithms. we have reflected on and highlighted the complexities of evaluating and quantifying the detection capability of a multipurpose syndromic service, which may explain the lack of published evidence on this subject. however, to address questions from users of syndromic surveillance about detection capabilities, we need to avoid over-simplifications and provide descriptions which directly address the complexities and wide-ranging utility of these services. therefore, we argue that syndromic surveillance service evaluations need to measure separately different types of event that the service aims to detect and to consider all surveillance 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 evaluating multi-purpose syndromic surveillance systems – a complex problem 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi stages. whilst the authors support the use of the cdcs framework for evaluation of surveillance systems [2], we also believe the complexity of multi-purpose systems needs to be considered in such frameworks. firstly, separate answers are needed for different types of event both to address users’ specific questions and because different types of events will require different methods for evaluation. crucially, these separate evaluations should be done in the context of a multi-purpose service where other types of events can affect detection capabilities and the ability to identify causes is also addressed. secondly, syndromic services should be evaluated beyond the generation of statistical alarms to provide results that inform public health action. service evaluations should include consideration of the routine surveillance messages and the impact of public health actions for different event types. to quantify the detection capabilities of syndromic surveillance it is important to compare events that the system aims to detect with what was detected. however, in this commentary we have shown that for a multi-purpose service, defining and linking these events is complex. the complexities arise from the wide range of events covered by a multi-purpose service and the need to assess not just the performance of statistical algorithms but the whole service process. measure each event type separately when considering a multi-purpose syndromic surveillance service, no single measure can helpfully describe its detection capabilities across all the different types of events it aims to detect. therefore, it is important to consider all the different type of events to be detected and measure detection capabilities separately for each. measuring each type of event separately means that a different approach can be used for different event types, for instance how events are defined or the user questions to be addressed. involving key internal and external stakeholders (including users of the service) in the evaluation is very important to ensure relevance [17]. for example, stakeholders can steer how narrowly the event types are defined and to address issues such as whether it is sufficient to estimate detection for all gastrointestinal outbreaks or do users require separate estimates for specific pathogens e.g. cryptosporidium or rotavirus. when measuring each event type separately there is still a need to consider how other types might affect detection capabilities. for example, does the ability to detect the health impact of air pollution change during an influenza epidemic? also, where there are multi-purpose indicators, correct detection of one type of event could be considered as a false alarm for detecting another type of event. importantly, evaluating a multi-purpose service by measuring different event types separately is not the same as performing a series of parallel evaluations in each of which the service is treated as if it had only one purpose. clearly, it requires much more work to tackle each event type separately, particularly if a range of different approaches are needed. however, this will provide a much richer understanding of the service’s capabilities and enhance users’ interpretation and confidence in the service outputs. evaluating each stage in the surveillance process the automated statistical detection algorithm is just one stage in a syndromic service’s many processes [33]. the stages can be characterized as: data collection, storage and extraction; aggregation to syndromic indicators; application of detection algorithms; and interpretation, evaluating multi-purpose syndromic surveillance systems – a complex problem 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi reporting and taking action. it is important to evaluate the service as a whole, so detection involves not just automated alarms but their interpretation, prioritization, reporting and public health impact [34]. however, evaluating each stage in the process separately can provide useful insights into which factors affect the service’s ability to detect events [35]. firstly, evaluating data collection will reveal what proportion of the target population is covered by the service and whether there are any delays in receiving information. for example, a sentinel service will be unable to detect local outbreaks in locations not covered by the system [36]. secondly, the underlying codes, diagnoses or free text included in syndromic indicators will determine their sensitivity and specificity [28], for example, a multi-purpose indicator may be able to detect different diseases with varying success due to different disease characteristics [7]. evaluating detection algorithms enables users to choose the most appropriate method for their service, which may vary by event type. finally, evaluating the interpretation and reporting stage usually involves assessing which automated statistical alarms require further action, therefore this stage should improve ppv and specificity but with a cost for timeliness and possibly sensitivity [6]. considering each stage separately should enable service users to identify areas where a system can be improved, for example, what are the main causes of delays? or is more data being collected than can be analyzed? figure 5 summarizes how each stage can impact on sensitivity, ppv and timeliness as discussed above. each additional stage may introduce delays to timeliness and a drop in sensitivity but should increase the ppv. surveillance stage potential problems causing… failure to detect false alarms delays data collection, storage and extraction sentinel system does not cover location of ‘event’ data quality, duplicates, test data etc. delay between exposure and presenting to health care aggregation to syndromic indicators symptoms not covered by existing indicators similar symptoms caused by other reasons data processing application of detection algorithms alarm thresholds set too high (no alarm) or too low (more alarms than can be analysed) alarm thresholds set too low computational complexity also alarm volume impacts on next stage interpretation, reporting and taking action failure to take appropriate public health action following alarm failure to distinguish between false alarm and potential health threat staff time, waiting for ‘repeat’ alarms to provide confirmation, decision-making processes figure 5. impact on detection capabilities of different stages in syndromic surveillance. future work we have focused on the complexities surrounding evaluation of a multi-purpose syndromic service, therefore we have not considered other important issues such as cost-effectiveness or evaluating multi-purpose syndromic surveillance systems – a complex problem 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi the added value of additional data sources. however, understanding evaluation complexities will be useful for future studies into cost-effectiveness etc. evaluation of a multi-purpose syndromic surveillance service should not be a one-off process, it should be periodic creating a positive feedback loop. information about a service’s detection capabilities should be updated as new evidence comes to light, or in response to major incidents such as the current covid19 pandemic. also, the most valuable information for assessing a service will come from its on-going performance. therefore, a syndromic service should have clear objectives and maintain a database of past events of different types and detections to enable on-going validation [37]. the process of identifying the different types of event that the users want a multi-purpose syndromic service to detect should help identify gaps in our knowledge about service detection capabilities, and in turn, this should help guide research priorities. acknowledgements the authors would like to thank the members of phe’s real-time syndromic surveillance team who helped develop england’s complex multi-purpose syndromic surveillance system, including: amardeep bains, sally harcourt, helen hughes, paul loveridge, sue smith and ana soriano. rm, gs, il and aje are affiliated to the national institute for health research health protection research unit (nihr hpru) in emergency preparedness and response. gs, oe, il, nm and aje are affiliated to the nihr hpru in gastrointestinal infections. io is affiliated to the nihr hpru in behavioral science and evaluation. the views expressed are those of the author(s) and not necessarily those of the nihr, phe or the department of health and social care. financial disclosure no financial disclosures. competing interests no competing interests. references 1. triple s. 2011. project. assessment of syndromic surveillance in europe. lancet. 378, 1833-34. pubmed https://doi.org/10.1016/s0140-6736(11)60834-9 2. sosin dm. 2003. draft framework for evaluating syndromic surveillance systems. j urban health. 80, i8-13. pubmed 3. jefferson h, dupuy b, chaudet h, texier g, green a, et al. 2008. evaluation of a syndromic surveillance for the early detection of outbreaks among military personnel in a tropical country. j public health (oxf). 30, 375-83. pubmed https://doi.org/10.1093/pubmed/fdn026 4. yih wk, deshpande s, fuller c, heisey-grove d, hsu j, et al. 2010. evaluating real-time syndromic surveillance signals from ambulatory care data in four states. public health rep. 125, 111-20. pubmed https://doi.org/10.1177/003335491012500115 https://pubmed.ncbi.nlm.nih.gov/22118433 https://doi.org/10.1016/s0140-6736(11)60834-9 https://pubmed.ncbi.nlm.nih.gov/12791773 https://pubmed.ncbi.nlm.nih.gov/18413353 https://doi.org/10.1093/pubmed/fdn026 https://pubmed.ncbi.nlm.nih.gov/20402203 https://doi.org/10.1177/003335491012500115 evaluating multi-purpose syndromic surveillance systems – a complex problem 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi 5. buckeridge dl, burkom h, campbell m, hogan wr, moore aw. 2005. algorithms for rapid outbreak detection: a research synthesis. j biomed inform. 38, 99-113. pubmed https://doi.org/10.1016/j.jbi.2004.11.007 6. faverjon c, berezowski j. 2018. choosing the best algorithm for event detection based on the intend application: a conceptual framework for syndromic surveillance. j biomed inform. 85, 126-35. pubmed https://doi.org/10.1016/j.jbi.2018.08.001 7. yuan m, boston-fisher n, luo y, verma a, buckeridge dl. 2019. a systematic review of aberration detection algorithms used in public health surveillance. j biomed inform. 94, 103181. pubmed https://doi.org/10.1016/j.jbi.2019.103181 8. andersson t, bjelkmar p, hulth a, lindh j, stenmark s, et al. 2014. syndromic surveillance for local outbreak detection and awareness: evaluating outbreak signals of acute gastroenteritis in telephone triage, web-based queries and over-the-counter pharmacy sales. epidemiol infect. 142, 303-13. pubmed https://doi.org/10.1017/s0950268813001088 9. smith ge, elliot aj, lake i, edeghere o, morbey r, et al. 2019. public health england real-time syndromic surveillance t. syndromic surveillance: two decades experience of sustainable systems its people not just data! epidemiol infect. 147, e101. pubmed https://doi.org/10.1017/s0950268819000074 10. thomas mj, yoon pw, collins jm, davidson aj, mac kenzie wr. 2018. evaluation of syndromic surveillance systems in 6 us state and local health departments. j public health manag pract. 24, 235-40. pubmed https://doi.org/10.1097/phh.0000000000000679 11. yoon pw, ising ai, gunn je. 2017. using syndromic surveillance for all-hazards public health surveillance: successes, challenges, and the future. public health rep. 132, 3s6s. pubmed https://doi.org/10.1177/0033354917708995 12. connelly jb. 2007. evaluating complex public health interventions: theory, methods and scope of realist enquiry. j eval clin pract. 13, 935-41. pubmed https://doi.org/10.1111/j.1365-2753.2006.00790.x 13. lalkhen ag, mccluskey a. 2008. clinical tests: sensitivity and specificity. bja educ. 8, 221-23. 14. mathes rw, lall r, levin-rector a, sell j, paladini m, et al. 2017. evaluating and implementing temporal, spatial, and spatio-temporal methods for outbreak detection in a local syndromic surveillance system. plos one. 12, e0184419. pubmed https://doi.org/10.1371/journal.pone.0184419 15. bundle n, verlander nq, morbey r, edeghere o, balasegaram s, et al. 2019. monitoring epidemiological trends in back to school asthma among preschool and school-aged children using real-time syndromic surveillance in england, 2012–2016. j epidemiol community health. 73, 825-31. pubmed https://doi.org/10.1136/jech-2018-211936 16. thien f. 2018. melbourne epidemic thunderstorm asthma event 2016: lessons learnt from the perfect storm. respirology. 23, 976-77. pubmed https://doi.org/10.1111/resp.13410 https://pubmed.ncbi.nlm.nih.gov/15797000 https://doi.org/10.1016/j.jbi.2004.11.007 https://pubmed.ncbi.nlm.nih.gov/30092359 https://doi.org/10.1016/j.jbi.2018.08.001 https://pubmed.ncbi.nlm.nih.gov/31014979 https://doi.org/10.1016/j.jbi.2019.103181 https://pubmed.ncbi.nlm.nih.gov/23672877 https://doi.org/10.1017/s0950268813001088 https://pubmed.ncbi.nlm.nih.gov/30869042 https://doi.org/10.1017/s0950268819000074 https://pubmed.ncbi.nlm.nih.gov/28961606 https://doi.org/10.1097/phh.0000000000000679 https://pubmed.ncbi.nlm.nih.gov/28692397 https://doi.org/10.1177/0033354917708995 https://pubmed.ncbi.nlm.nih.gov/18070265 https://doi.org/10.1111/j.1365-2753.2006.00790.x https://pubmed.ncbi.nlm.nih.gov/28886112 https://doi.org/10.1371/journal.pone.0184419 https://pubmed.ncbi.nlm.nih.gov/31262728 https://doi.org/10.1136/jech-2018-211936 https://pubmed.ncbi.nlm.nih.gov/30230659 https://doi.org/10.1111/resp.13410 evaluating multi-purpose syndromic surveillance systems – a complex problem 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi 17. wallstrom gl, wagner m, hogan w. 2005. high-fidelity injection detectability experiments: a tool for evaluating syndromic surveillance systems. mmwr suppl. 54, 8591. pubmed 18. todkill d, elliot aj, morbey r, harris j, hawker j, et al. 2016. what is the utility of using syndromic surveillance systems during large subnational infectious gastrointestinal disease outbreaks? an observational study using case studies from the past 5 years in england. epidemiol infect. 144, 2241-50. pubmed https://doi.org/10.1017/s0950268816000480 19. madouasse a, marceau a, lehebel a, brouwer-middelesch h, van schaik g, et al. 2013. evaluation of a continuous indicator for syndromic surveillance through simulation. application to vector borne disease emergence detection in cattle using milk yield. plos one. 8, e73726. pubmed https://doi.org/10.1371/journal.pone.0073726 20. van den wijngaard c, van asten l, van pelt w, nagelkerke nj, verheij r, et al. 2008. validation of syndromic surveillance for respiratory pathogen activity. emerg infect dis. 14, 917-25. pubmed https://doi.org/10.3201/eid1406.071467 21. fan y, wang y, jiang h, yang w, yu m, et al. 2014. evaluation of outbreak detection performance using multi-stream syndromic surveillance for influenza-like illness in rural hubei province, china: a temporal simulation model based on healthcare-seeking behaviors. plos one. 9, e112255. pubmed https://doi.org/10.1371/journal.pone.0112255 22. noufaily a, enki dg, farrington p, garthwaite p, andrews n, et al. 2013. an improved algorithm for outbreak detection in multiple surveillance systems. stat med. 32, 1206-22. pubmed https://doi.org/10.1002/sim.5595 23. morbey ra, elliot aj, charlett a, ibbotson s, verlander nq, et al. 2014. using public health scenarios to predict the utility of a national syndromic surveillance programme during the 2012 london olympic and paralympic games. epidemiol infect. 142, 984-93. pubmed https://doi.org/10.1017/s095026881300188x 24. colon-gonzalez fj, lake ir, morbey ra, elliot aj, pebody r, et al. 2018. a methodological framework for the evaluation of syndromic surveillance systems: a case study of england. bmc public health. 18, 544. pubmed https://doi.org/10.1186/s12889018-5422-9 25. noufaily a, morbey ra, colon-gonzalez fj, elliot aj, smith ge, et al. 2019. comparison of statistical algorithms for daily syndromic surveillance aberration detection. bioinformatics. 35, 3110-18. pubmed https://doi.org/10.1093/bioinformatics/bty997 26. vega t, lozano je, meerhoff t, snacken r, mott j, et al. 2013. influenza surveillance in europe: establishing epidemic thresholds by the moving epidemic method. influenza other respir viruses. 7, 546-58. pubmed https://doi.org/10.1111/j.17502659.2012.00422.x 27. elliot aj, hughes he, astbury j, nixon g, brierley k, et al. 2016. the potential impact of media reporting in syndromic surveillance: an example using a possible https://pubmed.ncbi.nlm.nih.gov/16177698 https://pubmed.ncbi.nlm.nih.gov/27033409 https://doi.org/10.1017/s0950268816000480 https://pubmed.ncbi.nlm.nih.gov/24069227 https://doi.org/10.1371/journal.pone.0073726 https://pubmed.ncbi.nlm.nih.gov/18507902 https://doi.org/10.3201/eid1406.071467 https://pubmed.ncbi.nlm.nih.gov/25409025 https://doi.org/10.1371/journal.pone.0112255 https://pubmed.ncbi.nlm.nih.gov/22941770 https://pubmed.ncbi.nlm.nih.gov/22941770 https://doi.org/10.1002/sim.5595 https://pubmed.ncbi.nlm.nih.gov/23902949 https://pubmed.ncbi.nlm.nih.gov/23902949 https://doi.org/10.1017/s095026881300188x https://pubmed.ncbi.nlm.nih.gov/29699520 https://doi.org/10.1186/s12889-018-5422-9 https://doi.org/10.1186/s12889-018-5422-9 https://pubmed.ncbi.nlm.nih.gov/30689731 https://doi.org/10.1093/bioinformatics/bty997 https://pubmed.ncbi.nlm.nih.gov/22897919 https://doi.org/10.1111/j.1750-2659.2012.00422.x https://doi.org/10.1111/j.1750-2659.2012.00422.x evaluating multi-purpose syndromic surveillance systems – a complex problem 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e15, 2021 ojphi cryptosporidium exposure in north west england, august to september 2015. euro surveill., 21. pubmed https://doi.org/10.2807/1560-7917.es.2016.21.41.30368 28. betancourt ja, hakre s, polyak cs, pavlin ja. 2007. evaluation of icd-9 codes for syndromic surveillance in the electronic surveillance system for the early notification of community-based epidemics. mil med. 172, 346-52. pubmed https://doi.org/10.7205/milmed.172.4.346 29. bourgeois ft, olson kl, brownstein js, mcadam aj, mandl kd. validation of syndromic surveillance for respiratory infections. ann emerg med. 2006;47:265 e1. 30. morbey ra, elliot aj, harcourt s, smith s, de lusignan s, et al. 2018. estimating the burden on general practitioner services in england from increases in respiratory disease associated with seasonal respiratory pathogen activity. epidemiol infect. 146, 1389-96. pubmed https://doi.org/10.1017/s0950268818000262 31. wallstrom gl, hogan wr. 2007. unsupervised clustering of over-the-counter healthcare products into product categories. j biomed inform. 40, 642-48. pubmed https://doi.org/10.1016/j.jbi.2007.03.008 32. paterson bj, kool jl, durrheim dn, pavlin b. 2012. sustaining surveillance: evaluating syndromic surveillance in the pacific. glob public health. 7, 682-94. pubmed https://doi.org/10.1080/17441692.2012.699713 33. morbey ra, elliot aj, charlett a, verlander nq, andrews n, et al. 2015. the application of a novel ‘rising activity, multi-level mixed effects, indicator emphasis’ (rammie) method for syndromic surveillance in england. bioinformatics. 31, 3660-65. pubmed https://doi.org/10.1093/bioinformatics/btv418 34. smith ge, elliot aj, ibbotson s, morbey r, edeghere o, et al. 2017. novel public health risk assessment process developed to support syndromic surveillance for the 2012 olympic and paralympic games. j public health (oxf). 39, e111-7. pubmed 35. buckeridge dl. 2007. outbreak detection through automated surveillance: a review of the determinants of detection. j biomed inform. 40, 370-79. pubmed https://doi.org/10.1016/j.jbi.2006.09.003 36. morbey r, hughes h, smith g, challen k, hughes tc, et al. 2019. potential added value of the new emergency care dataset to ed-based public health surveillance in england: an initial concept analysis. emerg med j. 36, 459-64. pubmed https://doi.org/10.1136/emermed-2018-208323 37. craig at, kama m, samo m, vaai s, matanaicake j, et al. 2016. early warning epidemic surveillance in the pacific island nations: an evaluation of the pacific syndromic surveillance system. trop med int health. 21, 917-27. pubmed https://doi.org/10.1111/tmi.12711 https://pubmed.ncbi.nlm.nih.gov/27762208 https://doi.org/10.2807/1560-7917.es.2016.21.41.30368 https://pubmed.ncbi.nlm.nih.gov/17484301 https://doi.org/10.7205/milmed.172.4.346 https://pubmed.ncbi.nlm.nih.gov/29972108 https://pubmed.ncbi.nlm.nih.gov/29972108 https://doi.org/10.1017/s0950268818000262 https://pubmed.ncbi.nlm.nih.gov/17509942 https://doi.org/10.1016/j.jbi.2007.03.008 https://pubmed.ncbi.nlm.nih.gov/22817479 https://doi.org/10.1080/17441692.2012.699713 https://pubmed.ncbi.nlm.nih.gov/26198105 https://doi.org/10.1093/bioinformatics/btv418 https://pubmed.ncbi.nlm.nih.gov/27451417 https://pubmed.ncbi.nlm.nih.gov/17095301 https://doi.org/10.1016/j.jbi.2006.09.003 https://pubmed.ncbi.nlm.nih.gov/31253597 https://doi.org/10.1136/emermed-2018-208323 https://pubmed.ncbi.nlm.nih.gov/27118150 https://doi.org/10.1111/tmi.12711 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts comparing syndromic surveillance and poison center data for snake bites in missouri karen h. pugh*1, amy kelsey2 and rebecca tominack3, 1 1st. louis university school of medicine and school of public health, saint louis, mo, usa; 2missouri department of health and senior services, jefferson city, mo, usa; 3missouri poison center, saint louis, mo, usa objective this study intends to use two different surveillance systems available in missouri to explore snake bite frequency and geographic distribution. introduction in 2010, there were 4,796 snake bite exposures reported to poison centers nationwide (1). health care providers frequently request help from poison centers regarding snake envenomations due to the unpredictability and complexity of prognosis and treatment. the missouri poison center (mopc) maintains a surveillance database keeping track of every phone call received. essence, a syndromic surveillance system used in missouri, enables surveillance by chief complaint of 84 different emergency departments (ed) in missouri (accounting for approximately 90% of all ed visits statewide). since calling a poison center is voluntary for health care providers, poison center data is most likely an underestimation of the true frequency of snake envenomations. comparing mopc and essence data for snake envenomations would enable the mopc to have a more accurate depiction of snake bite frequency in missouri and to see where future outreach of poison center awareness should be focused. methods archived data from toxicall®, the mopc surveillance system, was used to query the total number of snake bite cases from 01/01/2007 until 12/31/2011 called into the mopc center by hospitals that also participate essence. next, essence data was used to estimate the total number of snake envenomations presenting to eds in missouri. this was accomplished using the same date range as well as searching for key terms in the chief complaints that would signify a snake bite. the results of each datasearch were compared and contrasted by missouri region. results the toxicall® search showed a total of 324 snake bite cases. the initial essence data query showed a total of 1983 snake bite cases. after certain data exclusions, there was a total of 1763 essence snake bite visits. this suggests that approximately 18% of all snake bite visits reported in missouri essence were called into the mopc. the results are demonstrated by missouri region in figure 1. this figure also shows that the greatest number of essence visits for snake bites were reported by southwest region hospitals whereas the eastern region hospitals placed the greatest number of calls to mopc regarding snake bites. conclusions the total number of snake bite cases from missouri essence ed visits is much greater than the number of snake bites cases called into the mopc by essence participating hospitals. this underutilization of the poison center demonstrates the increased need for awareness of the mopc’s free services. in missouri, the mopc should target hospitals in the southwest region for outreach in particular based on these findings. poison centers are staffed by individuals trained in all types of poisonings and maintain a list of consulting physicians throughout the united states experienced in management and treatment of venomous snake bites (2). any heathcare facility would benefit from mopc assistance. finally, syndromic surveillance allows for quick and easy data compilation, however there are some difficulties when attempting to search for a particular condition. communication and partnership between two different public health organizations will be beneficial toward future public health studies. keywords essence; surveillance; missouri; poison center; snake references 1. bronstein ac, spyker da, cantilena lr, green jl, rumack bh, dart rc. 2010 annual report of the american association of poison control centers’ national poison data system (npds): 28th annual report. clinical toxicology. 2011;49:910-41. 2. gold bs, barish ra, dart rc. north american snake envenomation: diagnosis, treatment, and management. emerg med clin n am. 2004;22:423-43. *karen h. pugh e-mail: khill9@slu.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e102, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts adaptation of guardian for syndromic surveillance during the nato summit julio c. silva1, dino p. rumoro1, shital c. shah1, gillian s. gibbs*1, marilyn m. hallock1, michael waddell2 and shon doseck2 1rush university, chicago, il, usa; 2pangaea information technologies, chicago, il, usa objective to develop and implement a framework for special event surveillance using guardian, as well as document lessons learned postevent regarding design challenges and usability. introduction special event driven syndromic surveillance is often initiated by public health departments with limited time for development of an automated surveillance framework, which can result in heavy reliance on frontline care providers and potentially miss early signs of emerging trends. to address timelines and reliability issues, automated surveillance system are required. methods the north atlantic treaty organization (nato) summit was held in chicago, il, may 19-21, 2012. during the nato summit, the chicago department of public health (cdph) was charged with collecting and analyzing syndromic surveillance data from emergency department (ed) visits that may indicate a man-made or naturally occurring infectious disease threat. ten days prior to the nato summit surveillance period, rush university medical center (rumc) received a guidance document from cdph outlining the syndromes for systematic surveillance, specifically febrile rash illness, localized cutaneous lesion, acute febrile respiratory illness, gastrointestinal illness, botulism-like illness, hemorrhagic illness, along with unexplained deaths or severe illness potentially due to infectious disease and cases due to toxins or suspected poisoning. rumc researchers collected relevant icd-9 codes for each syndrome category. guardian (1), an automated surveillance system, was programmed to scan patient charts and match free text using national library of medicine free-text term to unique medical concept, which were further mapped to relevant icd-9 codes. the baselines were developed using ed patient data from 1/1/2010 to 12/31/2011. statistical references were established for unsmoothed, 24 hour counts (baseline = average; threshold = +2 standard deviations). during the nato surveillance timeframe (may 1326, 2012) automated results with prior reporting period’s counts, reference statistics, and charts were electronically sent to cdph. in addition, ed charge nurses made manual surveillance reports by telephone at least daily. open lines of communication were maintained between rumc and cdph during the event to discuss potential positive cases. in addition, a post-event debriefing was conducted to document lessons learned. results the automated guardian surveillance reports not only provided timely counts of potentially positive cases for each syndrome but also provided trend analysis with baseline measures. the guardian user interface was used to explain what data points could trigger positive cases. the epic system was used to review patient charts, if further explanation was necessary. the observed counts never exceeded +2 standard deviations during the nato surveillance period for any of the syndromes. based on the debriefing meeting between rumc and cdph, the top three achievements and lessons learned were as follows: 1. quick turnaround time (~ 10 days) from surveillance concept development to automated implementation using guardian 2. surveillance data was timely and reliable 3. additional statistical information was beneficial to put trends in context 4. system may be too sensitive resulting in false alarms and additional investigative burden on public health departments 5. need for development of user-interfaces with drill down capabilities to patient level data 6. clinicians don’t necessarily utilize exact terminology used in icd-9 codes which could result in undetected cases. conclusions this exercise successfully highlights rapid development and implementation of special event driven automated surveillance as well as collaborative approach between front-line entities such as emergency departments, surveillance researchers, and the department of public health. in addition, valuable lessons learned with potential solutions are documented for further refinements of such surveillance activities. keywords emergency department; nato summit; automated surveillance acknowledgments guardian is funded by us department of defense, telemedicine and advanced technology research center, award numbers w81xwh-091-0662 and w81xwh-11-1-0711. references j. silva, d. rumoro, m. hallock, s. shah, g. gibbs, m. waddell, k. thomas, disease profile development methodology for syndromic surveillance of biological threat agents, emerging health threats journal, 2011, 4:11129. *gillian s. gibbs e-mail: gillian_gibbs@rush.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e192, 2013 design thinking to create a remote patient monitoring platform for older adults' homes 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi design thinking to create a remote patient monitoring platform for older adults' homes h. a. kolnick, jennifer e. miller, olivia dupree, lisa gualtieri, phd, scm department of public health and community medicine, tufts university school of medicine abstract how might clinicians collect the vitals needed for effective scheduled video visits for older adults? this challenge was presented by aarp to graduate students in a digital health course at tufts university school of medicine. the design thinking process was used to create a product that would meet this need, keeping the needs and constraints of older adults, especially those with chronic conditions or other barriers to health, central to the solution. the initial steps involved understanding and empathizing with the target audience through interviews and by developing personas and scenarios that identified barriers and opportunities. the later steps were to ideate potential solutions, design a prototype, and define product success. the design thinking process led to the design of home health hub, a remote patient monitoring (rpm) platform designed to meet the unique needs of older adults. additionally, home health hub can conceivably benefit all users of telehealth, regardless of health status—an important need during the covid-19 pandemic, and in general due to increased use of virtual visits. home health hub is one example of what can be achieved with the dedicated use of design thinking. the design thinking process can benefit public health practice as a whole by encouraging practitioners to delve into a problem to find the root causes and empathize with the needs and constraints of stakeholders to design innovative, human-centered solutions. *correspondence: lisa.gualtieri@tufts.edu doi: 10.5210/ojphi.v13i1.11582 copyright ©2021 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in t he copy and the copy is used for educational, not-for-profit purposes. 1. background a growing population of older adults (people 50 years of age and older) in the us and increased adoption of telehealth have given rise to a need for accessible and effective methods to gather patient vitals remotely. telehealth visits are increasing, and there is a market for and widespread interest in remote patient monitoring (rpm) devices. there are already rpm devices and systems on the market which meet the needs of select populations. the authors sought to design an rpm platform that would combine the best features of existing rpm solutions and designate a space in the home for health care to meet the needs of older adults regardless of level of mobility, digital literacy, access to transportation, and wireless internet [1]. design thinking to create a remote patient monitoring platform for older adults' homes 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi 1.1. telehealth adoption telehealth is the use of electronic information and telecommunications technologies to provide clinical health care, health education, public health and health administration over a long-distance [2]. many different technologies can be used to provide health care when a patient and provider aren’t in the same location at the same time including videoconferencing, imaging, streaming media, the internet, and wireless communication. telemedicine, on the other hand, refers specifically to remote clinical health care, while telehealth refers to a broader range of healthrelated services. in 2017, the american hospital association (aha) found that 76 percent of u.s. hospitals connect with patients and consulting practitioners using telehealth [3]. in march of 2020 early in the pandemic, telehealth visits increased by 154 percent compared to 2019. providers were forced to perfect a complicated system of health information technology virtually overnight. while use of telehealth has been steadily increasing for decades, it has recently been the focus of health providers and public health departments nationwide as covid-19 has forced people into their homes and away from hospitals to avoid infection [1]. to reduce the spread of the coronavirus, telehealth options for needed care have proliferated. it is now possible to use telehealth for an annual wellness visit, prescription consultation, dermatology, eye exams, nutrition counseling, mental health counseling, and even urgent care conditions like sinusitis, urinary tract infections, rash, or pain [4]. in addition to reduction of exposure to covid-19, there are many other benefits to the use of telehealth. telehealth can reduce the need to commute and make care more accessible for people by reducing transportation-related barriers for those with low mobility, those who live in rural areas, those who don’t drive and those who don’t have access to a vehicle or public transportation. people without access to child care, those who can’t get the time off of work, or those who live in an area with extreme heat or weather conditions can also benefit. telehealth is also often offered with little to no co-pay and allows for overall reduced spending among all stakeholders, patient, provider, and insurer alike. telehealth is particularly beneficial for older adults, the focus of this design thinking project, because it allows them to meet with their providers and own their care, regardless of level of mobility, often without help from a loved one. in more ways than one, telehealth helps to close the equity gap caused by many of the social determinants of health. 1.2. remote patient monitoring one major concern shared by patients and providers alike regards the collection of patient vitals. the need for providers to know their patients’ vital signs is particularly crucial among older adults and those with chronic conditions such as hypertension and diabetes. many solutions to this need exist in various capacities. remote vital sign collection for telehealth visits, or remote patient monitoring, can be done in a variety of ways including kiosks and home kits. kiosks refer to stations in pharmacies, grocery stores, or other public locations where patients can have their vitals checked in a self-service fashion. kits, or “home kits” refers to a suite of rpm devices that can be kept and used at home: a scale, thermometer, blood pressure cuff/monitor, blood glucose monitor, pulse oximetry, and even a smartwatch—many of which now possess electrocardiogram (ecg) capabilities, fall detection, and respiratory rate tracking. use of and design thinking to create a remote patient monitoring platform for older adults' homes 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi interest in rpm devices is at an all-time high. according to a 2019 survey conducted by a healthcare solutions provider, 64 percent of participants over the age of 40 said they would use a health monitoring device if it would reduce their number of physical trips to the doctor or hospital [5]. an analysis of the strengths, weaknesses, opportunities, and threats (swot) of kiosks and home kits was used to determine where to focus the ideation stage of the design thinking process and refine the space of possible solutions (complete swot analyses available in appendix a). in this analysis, we found that kiosks had the advantages of being cost-effective and not raising issues of storage or maintenance for patients. yet they were not accessible for patients living in rural areas or those with limited mobility. further, cleanliness and disinfection were issues, especially during a pandemic. existing home kits, while convenient and hygienic, were still found to possess several weaknesses related to digital literacy, wi-fi access, and the potential for error with non-medicalgrade products. 1.3. remote patient monitoring platforms we shifted our research from kiosks and home kits to rpm platforms providing devices for inhome use available on the market. the convenience and benefits of rpm could not be denied. studies have shown that home rpm can increase medication compliance, improve patient satisfaction, and decrease emergency room (er) visits, hospital admissions, and medical spending by all stakeholders [6]. rpm adoption by providers is high; 88 percent of healthcare providers have already invested in or are shopping rpm technologies, specifically to support chronically ill patients with increased risk for hospitalization [7]. we considered two popular platforms: livongo and 100plus. livongo, a prototype of sorts, goes above and beyond what many other platforms are willing or able to do. 100plus is simpler and similar to the majority of other platforms that exist for medicare patients only. livongo intends to empower its members with chronic conditions to live fuller and healthier lives. they have specialists available to help support the patient to navigate their treatment plan, out-ofrange readings, and any other concerns that may arise. they claim to reduce deaths from diabetes by 21 percent, reduce heart attacks by 14 percent, and reduce peripheral heart disease by 43 percent. livongo focuses on care for adults with specific health conditions and a high level of digital literacy [8]. 100plus offers a simple payment model and straightforward configuration of their devices. all of their devices are fully cellular and ready to use right out of the box—no wi-fi, bluetooth, or sim cards are needed. we believe this will be a key feature to support patients without internet or wifi access. they work exclusively with providers to meet the needs of older adults with medicare. providers bill the center for medicare and medicaid services (cms) for all cpt codes related to rpm and/or chronic care management. 100plus profits from a percentage of the provider’s reimbursement from one cpt code and a small fee charged to the patient. providers are often able to increase revenue with this model due to cms’ 2020 increase of available reimbursement potential. 100plus works specifically with medicare patients and their products do not provide individualized feedback nor do they offer patients a portal to review and store results [9]. design thinking to create a remote patient monitoring platform for older adults' homes 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi 2. target audience a majority of older adults are open to using rpm devices when the practice translates to less time spent traveling to meet with their health care providers [5]. the high level of interest, combined with the increased benefit to the age group, led the authors to identify older adults as the primary user population in the design thinking project. in consideration of family members and health care professionals who assist with and provide care to older adults, we also identified a secondary user population: family and professional caregivers. we identified which specific target populations of our overall user population would benefit most from an accessible and effective solution to collecting vitals remotely. the target populations identified were as follows: immunocompromised individuals and those with chronic conditions, those with concerns about visiting the doctor during the global covid-19 pandemic, those living in rural locations, individuals with mobility issues or transportation barriers, and finally, any older adult with a preference for telehealth. the process of defining and segmenting our audience also led the authors to identify individuals and groups who were perceived to be stakeholders in a potential solution. we determined that the main stakeholders would be patients aged 50 and older, health care providers, and insurance providers—namely, cms. cms is the largest payer of healthcare services in the country, and millions of older adults in our primary user population rely on medicare to help cover the cost of their medical bills [10]. other stakeholders we identified include producers and manufacturers of rpm devices. patients, and caregivers of patients, in long-term or skilled-care facilities would be least likely to benefit from our design-thinking solution. this is primarily due to the assumption that, in most cases, these facilities would already be in possession of devices to collect patient vitals and have health care providers on staff to conduct visits with patients. 2.1. interviews designing and conducting interviews was an opportunity to learn more about stakeholder populations who are affected by the need for accessible and effective methods to gather vitals for telehealth visits. (the complete list of interview questions available in appendix b). four interviews were completed using a convenience sample, with a focus on collecting data related to internet access, smartphone ownership, comfort and perceived skill using digital technology, history of chronic conditions, and self-collecting vitals. seventy-five percent of interviewees stated they had wi-fi, a smart phone, were comfortable using digital technology, and had a chronic condition. for patients who had taken vitals at home before, we asked several questions to understand perception and experience, including the level of perceived difficulty associated with taking their own vitals from home. certain themes arose in the interviews that influenced the design process. one interviewee in her 70s mentioned the struggle to find her international normalized ratio (inr) kit whenever she needed to test the thickness of her blood. another interviewee stated, “my whole bedroom is like a pharmacy now… i’ve got an entire cabinet of supplies here,” in talking about storing supplies as a caregiver [11]. these responses highlighted our research and reinforced the need for a centralized place in the home dedicated to health. additionally, we assessed whether interviewees believed taking vitals regularly to be important design thinking to create a remote patient monitoring platform for older adults' homes 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi and to score level of difficulty. finally, the interviews uncovered whether self-taken vitals were shared with doctors and if the measurements had any influence on the conversation that took place with their care provider. 2.2. personas and scenarios the process of designing and conducting interviews led to the development of four unique personas who could potentially benefit from rpm solutions to support their telehealth use. (a complete list of personas and scenarios is in appendix c). jim is a 78-year-old cisgender male veteran who lives in rural minnesota. he lives with multiple chronic conditions, including cardiovascular disease, ptsd, and declining mobility. his social supports include a small circle of friends and his children—however, jim values and wishes to protect his independence more as he ages. jim learned from an advertisement in the mail that his health care facility is beginning to offer telehealth visits. the telehealth option would save him a considerable amount of time, as he is accustomed to frequent travel into the city to meet with his care team. billy is a 63-year-old african american cisgender male who has had high blood pressure for 10 years. he has been managing his high blood pressure with in-person visits to the doctors yearly. he has internet access at home and a smartphone but low digital literacy. billy was recently diagnosed with type 2 diabetes and would love to learn how to safely manage his care from home. this new diabetes diagnosis will require him to visit his doctor every three months. in early march, billy visited his doctor to have his vitals checked and a1c tested. shortly after this visit, covid19 infections increased, and he was advised to stay home as much as possible. in june, he was due for more testing but was very uneasy going into the doctor's office due to the pandemic and his new diagnosis. billy would love to learn how to safely manage his care from home, especially during a global pandemic. carmen is a 56-year-old cisgender female who is recently retired and loving her new free time. she had a mild heart attack in her late forties and has since taken charge of her health in a big way. she still has bouts of hypertension and works with her doctor to keep it at bay. she has wi-fi access at home and moderate digital literacy. she has an annual appointment coming up but doesn’t want to travel all the way to see her doctor because it will mean missing the beginning of her beloved salsa class. she wants to be able to check her blood pressure and meet with her provider from home. caveh is a 33-year-old nonbinary/genderqueer physical therapist with wi-fi access and high digital literacy skills. they help take care of their father rashad who has diabetes. caveh prefers to accompany rashad to his appointments but often has to miss one due to work restraints. they recently learned about the availability of telehealth visits from rashad’s primary care provider, but caveh is worried that vital health information will be missed without access to the same tools used in the doctor’s office. design thinking to create a remote patient monitoring platform for older adults' homes 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi 3. ideation the ideation process began by revisiting all of the existing solutions discovered while doing initial research. a swot analysis showed that kiosks are not ideal for rural patients nor those with limited mobility. wearable solutions will not allow all needed health metrics to be collected like weight and blood pressure. the notion of an all-in-one wearable device was appealing but the technology does not yet exist. the evaluated platforms offered considerable products and features, but none that fully supported the four personas. after evaluating existing solutions, the authors considered how the global pandemic is forcing people to spend more time at home—and how important it is to have dedicated areas in the home for specific activities, such as a home office. a source of inspiration was products which are designed to consolidate their function and save space in the home, such as murphy beds and folding desks. initially, a pull-down/murphy bed-style compartment was considered an option for consolidating rpm and other health-related devices. it could be stored vertically and hinged to the wall for easy access when needed. this idea infiltrated the ideation process. the ideation process also focused on the rpm tools the personas would need and how to organize them. beyond the concept of consolidation and having a dedicated space in the home for all rpm devices, the product needed to be usable, cellular-enabled, and have a modular design. 4. introducing: home health hub home health hub is the culmination of research, interviews, persona and scenario development, and ideation. rpm-focused companies such as livongo and 100plus have already demonstrated success bringing rpm tools to patients in need of vital collection. home health hub, goes a step further by offering a place in the home where all rpm devices can be stored and conveniently accessed. home health hub is designed to reduce the likelihood for devices to get lost by consolidating multiple devices into one solution. it also opens opportunities to solve other problems, such as where patients can safely store medications. home health hub creates one space in the home dedicated to health—offering a suite of rpm devices consolidated and housed in a modular, space-saving location which can also serve as a desk for patients to complete their telehealth visits. 4.1. prototype our design thinking process led to the development of a low-fidelity prototype for home health hub. when not in use, home health hub folds into a size slightly larger than a standard briefcase (see figure 1). the system features retractable handles which allow the user to easily carry it from storage to a surface for use. alternatively, home health hub can be securely attached to a wall using the included mounting hardware. the latter option allows home health hub to act as a designated space in the home for health-monitoring activities. home health hub plugs into a standard electrical outlet to supply power to the included devices. design thinking to create a remote patient monitoring platform for older adults' homes 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi figure #1 exterior view of home health hub note: a view of the exterior of home health hub from the front and side, displaying dimensions and key features. when home health hub is in use, it unfolds to reveal its function as a folding desk (figure 2). the upright side of the system includes shelves for the storage of medications and supplies. devices are stored in a modular format. there is a channel at the top of the desk to allow users to place tablets or phones upright for telehealth visits. home health hub offers five rpm devices, in addition to a cellular-enabled tablet for those patients who do not have a device at home. the five devices include a scale, thermometer, blood pressure monitor, blood glucose monitor, and smartwatch. the watch includes several features such as fitness tracking, fall detection, pulse oximetry, heart rate, ecg, as well as respiratory rate. design thinking to create a remote patient monitoring platform for older adults' homes 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi figure #2 home health hub in situ and bird’s eye view note: on the left, a view of home health hub in situ. the system is mounted to the wall and reveals the shelves allowing for the storage of medical supplies. on the right, a bird’s eye view of home health hub including rpm devices. the process of creating the low-fidelity prototype for home health hub allowed the authors to merge and cement design ideas. it further helped to generate additional plans for the design of the system and the component devices. 4.2. features all home health hub devices are fully cellular, rechargeable, and ready to use out of the box. they don’t require internet access or batteries. in the research stage of our process, digital literacy was identified as a key barrier to successful implementation of rpm devices for older adult telehealth users. cimperman and authors write that, “the level at which hts (home telehealth services) are perceived as easy to use and manage is the leading acceptance predictor in older users’ hts acceptance” [12]. this barrier presents an opportunity to design a product that is accessible to all users regardless of digital literacy. the simple patient portal provides personalized feedback on easy-to-read health metrics. it also allows its users to access community networking, and nutrition and fitness guides. technical and clinical support are standing by to guide our users through enrollment and can be reached over the phone, via text, or through our app 24/7. instant guidance is provided on out-of-range readings from expert health coaches. for interested users, the home health hub app patient portal is convenient and informative. however, use of the patient portal is completely optional and not required to get full use of the devices. varying levels of digital literacy and digital interest mean that some users may never care for the app regardless of how much customer support they receive. regardless of patient portal usage, the patient’s health metrics are sent seamlessly to their provider. design thinking to create a remote patient monitoring platform for older adults' homes 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi home health hub was designed to remove some of the most critical obstacles for providers. the provider dashboard consists of simple graphs and tables of health metrics providing a comprehensive understanding of each patient in a glance and seamlessly syncing with their ehr. home health hub strives to pay attention to compliance, so providers can focus on their patients. it is fully hipaa compliant for app and video care coordination. 4.3. payment model the authors developed a proposed payment model that utilizes partnerships with insurance providers to pay a monthly capitated rate for each user. additionally, cms has expanded reimbursements for rpm and chronic care management for the 2020 year increasing revenue potential for providers, ease of insurance coverage, and ability to offer the platform free to patients. this payment model is viable based on success in other industries. car insurance companies are lowering premiums for customers that drive safely [13]. a similar model could be applied to incentivize insurers to cover the cost of home health hub for their patients, knowing it will translate to savings [12]. additionally, adherence requirements ensure use and positive outcomes. if a patient is found to not be using their device according to treatment recommendations, they will be contacted by home health hub health coaches to troubleshoot and receive support with using their devices as directed. 5. limitations the authors designed multiple iterations of home health hub, beginning with low fidelity models and increasing the level of fidelity with each prototype; however, some limitations should be noted stemming from the context of this being work completed in a graduate digital health course. these limitations include the need to identify barriers to market entry, increase interview sample size and selection, and conduct further market research. the design thinking process established a creative framework for the authors to design a product which would meet the increasing need for older adults to connect with health care providers, monitor their health remotely, and assist with the organization of health artifacts. the proposed product should be further refined with a focus on producibility and market entry in order to increase the odds that it would be successful. the older adults and caregivers selected to be interviewed for this project were identified via a convenience sample, and a total of four interviews were conducted. the product may be better refined if informed by a larger interview pool or survey effort. a few rpm platforms were studied in the design thinking process and their best features were considered and improved upon in the creation of home health hub. a more robust comparative research analysis of existing rpm platforms and home health tools could improve the constitution of the product. design thinking to create a remote patient monitoring platform for older adults' homes 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi 6. next steps successful implementation and introduction of home health hub would be demonstrated by an overall decrease in medical spending, emergency room visits, hospital admissions, and hospital readmissions. likewise, an increase in provider revenue and medication compliance for home health hub users would be indicators of success. finally, the opportunity to partner with major healthcare providers would allow a wider audience beyond the initial target population to use and benefit from home health hub for preventative care regardless of age or health status. 7. conclusion home health hub, designed through the design thinking process, is proposed as a solution to telehealth and rpm needs. it is a place in the home designed specifically for users to be able to conveniently access their health care information, rpm devices, and providers. the authors designed a product aiming to address patient vital collection for telehealth appointments in the target population of older adults and beyond. the design thinking process carried the authors further in the development of home health hub than research would have alone. it was tempting to begin designing a product on day one—the very moment we were given a problem to solve. in retrospect, it is easy to see how you don’t know what you don’t know. the authors began the process with interviews that opened our eyes to our own unrealized judgments and biases. initially, we might not have included a patient portal in our design. but after interviewing older friends and loved ones we found that while some are less than interested in digital literacy, others are very tech-savvy and passionate about patient and provider engagement, and ownership of health metrics and records. we took the interviews and applied them to the design of our personas. the personas forced us to see the world from multiple perspectives and begin to envision a product that served them all equally and efficiently. once we had the personas in mind, we were able to clearly identify what kinds of barriers would affect each one and come up with solutions and opportunities to get beyond them. to develop the scenarios that led each persona to take an interest in home health hub, we imagined what a day in the life would be like for jim, billy, carmen, and caveh. when we began to ideate, we embodied a “yes, and” communication style and embraced each other’s ideas no matter how wacky they seemed at the onset. the “murphy bed of health,” which began as a silly injection, turned into one of the core features of our product. by the time we began prototyping home health hub, we had done enough research and ideation that we could see clearly what our target population needed and what we wanted to design. if there was a feature that seemed advantageous to include in home health hub, we tried to validate it. the authors were able to design the unicorn of all rpm platforms that addresses the limitations of existing platforms yet is feasible to implement. design thinking empowered us to work together to understand our problem and think critically and imaginatively about our solution in a way that wouldn’t otherwise have been possible. home health hub is the proud result of this process. design thinking provides a process that has the potential to solve other key public health challenges design thinking to create a remote patient monitoring platform for older adults' homes 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi by supporting a process that systematically focuses a group on creative solutions that address complex needs and constraints of stakeholder populations. references 1. covid-19 pandemic drives telehealth boom, but older adults can't connect. (2021, march 25). retrieved april 02, 2021, from https://www.ucsf.edu/news/2020/08/418201/covid-19pandemic-drives-telehealth-boom-older-adults-cant-connect 2. what is telehealth? how is telehealth different from telemedicine? (2019, october 17). retrieved december 18, 2020, from https://www.healthit.gov/faq/what-telehealth-howtelehealth-different-telemedicine 3. fact sheet. telehealth. (n.d.). retrieved december 18, 2020, from aha.org website: https://www.aha.org/factsheet/telehealth 4. understanding telehealth. (n.d.). retrieved december 18, 2020, from https://telehealth.hhs.gov/patients/understanding-telehealth/ 5. vivalnk. (2019, june 25). survey shows reducing doctor visits will drive remote patient monitoring adoption. retrieved december 18, 2020, from https://www.prnewswire.com/news-releases/survey-shows-reducing-doctor-visits-willdrive-remote-patient-monitoring-adoption-300874238.html 6. hennick c. (2020, april 27). how remote patient monitoring programs are beneficial. retrieved december 18, 2020, from publisher website: https://healthtechmagazine.net/article/2020/04/how-remote-patient-monitoring-programsare-beneficial 7. malkary g. (2019, october). trends in remote patient monitoring. retrieved december 18, 2020, from https://www.spyglassconsulting.com/abstracts/spyglass_rpm2019_abstract.pdf 8.livongo: an easy way to fit health into your life. hello.livongo.com. (n.d.). retrieved november 20, 2020, from https://hello.livongo.com/gen/tld?experiment_id=vwo168_gen 9. remote patient monitoring devices. 100plus. (n.d.). retrieved may 27, 2021 from https://www.100plus.com/ 10. quality initiatives general information. (2019, november). retrieved december 18, 2020, from https://www.cms.gov/medicare/quality-initiatives-patient-assessmentinstruments/qualityinitiativesgeninfo 11. dupree, o., kolnik, h., miller, j. (2019, november 23). personal interview https://www.healthit.gov/faq/what-telehealth-how-telehealth-different-telemedicine https://www.healthit.gov/faq/what-telehealth-how-telehealth-different-telemedicine https://hello.livongo.com/gen/tld?experiment_id=vwo168_gen https://www.cms.gov/medicare/quality-initiatives-patient-assessment-instruments/qualityinitiativesgeninfo https://www.cms.gov/medicare/quality-initiatives-patient-assessment-instruments/qualityinitiativesgeninfo design thinking to create a remote patient monitoring platform for older adults' homes 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi 12. cimperman m, brenčič mm, trkman p. 2016. analyzing older users’ home telehealth services acceptance behavior—applying an extended utaut model. int j med inform. 90, 22-31. doi:https://doi.org/10.1016/j.ijmedinf.2016.03.002. pubmed 13. metz j. (2020, december 10). usage-based insurance rewards good drivers. retrieved december 18, 2020, from https://www.forbes.com/advisor/car-insurance/usage-basedinsurance/ acknowledgments the authors express gratitude to alison bryant, phd, senior vice president, aarp research & enterprise lead, tech & digital equity, for providing the original challenge that led to this work. we also appreciate her guidance throughout the design thinking process and feedback on home health hub throughout the process. the authors also thank avi patel, md candidate. tufts school of medicine '23, for his thoughtful review of the document. appendix a swot analyses swot analysis: home kits strengths ● convenient ● no transportation required ● some have personalized messaging/coaching feature ● some are cellular weaknesses ● potential for error/not medical grade ● some require wi-fi ● require some degree of digital literacy opportunities ● emerging/unmet need due to covid19 ● wide range of design possibilities ● can be configured to meet various combinations of needs threats ● sanitation/cleanliness ● misuse due to lack of digital literacy swot analysis: kiosks strengths ● cost-effective ● doesn’t require individual purchase or storage of products weaknesses ● requires transportation/not ideal for rural health care https://doi.org/10.1016/j.ijmedinf.2016.03.002 https://pubmed.ncbi.nlm.nih.gov/27103194 design thinking to create a remote patient monitoring platform for older adults' homes 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi ● not ideal for patients with mobility concerns ● not available 24/7 ● not available for all vitals collection ● may become expensive if used often opportunities ● emerging/unmet need due to covid19 ● wide range of design possibilities ● can be configured to meet various combinations of needs threats ● pay out-of-pocket/not reimbursed by insurance ● misuse due to lack of digital literacy ● interpretation of results appendix b complete interview question list 1. do you have internet access at home? 2. do you own a smartphone? 3. are you comfortable using digital technology such as cellphones, computers, tablets? 4. do you have any chronic conditions that require regular monitoring? a. how many? 5. have you ever taken your vitals at home? a. if yes: i. are there health indicators that you monitor regularly? ii. how hard is it to take your vitals at home, on a scale of 1 (easy) to 10 (hard) 1. if score 1-4, why is it easy/relatively easy? 2. if score 5+, why is it relatively hard/hard? 6. how did you share your results with your doctor? 7. how much did your self-taken vitals influence your conversation with your doctor? a. if no: i. why not? (lack of resources, etc.) 8. do you think it’s important to check your vitals regularly? why or why not? appendix c complete list of personas and scenarios name jim age 78 design thinking to create a remote patient monitoring platform for older adults' homes 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi sex/gender cisgender male race/ethnicit y white (non-hispanic/latinx) marital status widower education level high school graduate location rural minnesota brief description jim is a veteran living in a rural setting, with mobility issues and chronic conditions (cardiovascular disease and ptsd). jim does not have wifi or a smartphone. he has an independent attitude and is somewhat introverted. his children and small circle of friends are his social supports. scenario jim has learned through a mailing advertisement that his psychiatrist and primary care provider, both associated with the same rural hospital, have begun offering virtual visits. jim would like to learn how to access care remotely due to his rural setting and declining mobility, but he does not feel confident that he can learn to use rpm technology on his own. jim’s children, who visit him regularly, agree it would be a good option for him and are ready to support him with setup. quote “it would be great if i could cut down on the amount i need to travel in order to see my doctors.” name billy age 63 sex/gender cisgender male race/ethnicit y black/african american marital status married education level high school graduate design thinking to create a remote patient monitoring platform for older adults' homes 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi location suburban massachusetts brief description billy lives with high blood pressure. he has internet access at home and a smartphone but has low digital literacy skills. billy was recently diagnosed with type 2 diabetes. scenario billy has been managing his high blood pressure with in-person visits to the doctors yearly. in december 2019, billy went into the doctor's office for a routine check-up and was diagnosed with type 2 diabetes. this new diabetes diagnosis will require him to visit his doctor every 3 months. in early march, billy visited his doctor to have his vitals checked and a1c tested. shortly after this visit, covid-19 hit and everyone was advised to stay in their homes. in june he was due for more testing but was very uneasy going into the doctor's office due to the current pandemic and his new diagnosis. billy would love to learn how to safely manage his care from home. quote “i want to do what’s best for my health, but i am worried about going into the doctor's office during a pandemic.” name carmen age 56 sex/gender cisgender female race/ethnicit y latina columbian marital status married education level bachelor’s degree location long island, ny brief description carmen recently retired after more than 30 years in hospital administration and is loving retired life! she can’t sit still. her weekly activities include salsa dance classes, singing in her church choir, a walking group with other women in her neighborhood, and swimming lessons. design thinking to create a remote patient monitoring platform for older adults' homes 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi scenario carmen had a mild heart attack in her late 40s and has taken charge of her health ever since. she eats well, exercises every day and is the healthiest she’s ever been. she still has bouts of high blood pressure and works with her doctor to keep it at bay. she has an annual visit coming up and laments having to go to the doctor. she’d rather be having fun! quote “i would love to have my annual visit from home. it takes too long to get to and from my doctor’s office and if i have to go in for my next appointment i’ll be late for salsa class!” name caveh age 33 sex/gender genderqueer/non-binary race/ethnicit y asian persian marital status single education level doctorate location san francisco, ca brief description caveh is a physical therapist and part-time caregiver for their father, rashad. they are tech-savvy and enthusiastic about helping rashad receive the best care possible. scenario caveh is very engaged in rashad’s health and prefers to accompany him to his doctor’s visits. unfortunately, this is not always possible due to their busy work and commute schedule. rashad has type 2 diabetes, so caveh helps rashad manage his care from home with the help of an insulin pump, regular exercise, healthy eating, stress management and regular observation of his blood pressure and cholesterol levels. caveh learns that his father’s provider is now offering virtual visits but is concerned that vital health information may be missed without access to the same tools used in the doctor’s office. design thinking to create a remote patient monitoring platform for older adults' homes 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e9, 2021 ojphi quote “if we could monitor my dad’s vitals and meet with his providers from home it would be easier for me to make sure he’s getting all the information and support he needs.” layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts geographical information systems: a tool to map and analyze disease spread indumathi srinath*1, barbara szonyi1, maria esteve-gassent1, blanca lupiani1, raju gautam1, alfonso clavijo2, sang-shin park1 and renata ivanek-miojevic1 1texas a &m, college station, tx, usa; 2texas veterinary medical diagnostic laboratories, college station, tx, usa objective use gis to illustrate and understand the association between environmental factors and spread of infectious diseases. introduction spatial methods are an important component of epidemiological research motivated by a strong correlation between disease spread and ecological factors (1). our case studies examine the relationship between environmental conditions, such as climate and location, and vector distribution and abundance. therefore, gis can be used as a platform for integrating local environmental and meteorological variables into the analysis of disease spread, which would help in surveillance and decision making. methods case study 1lyme disease -lyme disease is a tickborne infection caused by the bacterium borrelia burgdorferi. the goal of this study was to analyze the association between meteorological factors and lyme disease risk in humans in texas. a total of 1,212 cases reported from 138 counties in texas from jan 2000 to dec 2010 were analyzed. we used temperature and precipitation raster grids to generate humidity maps for texas region. our results indicated that there is a strong positive association between lyme disease incidence and humidity, with western cross timbers region having a higher risk then the low plains. case study 2spinach – motivated by the recent increase in foodborne outbreaks related to fresh produce, one of the objectives for this study was to use the geospatial analysis to elucidate factors that contribute to contamination of produce at preharvest. we collected 955 spinach samples from 13 produce farms in colorado and texas during 2010-2011 and tested the samples for listeria monocytogenes, escherichia coli o157:h7 and salmonella contamination. the spinach contamination results were then used in conjunction with the national resource information (nri) databases along with the ssurgo database to predict environmental and meteorological factors contributing to spinach contamination. our findings would help to reduce frequency of human foodborne illnesses related to fresh produce. case study 3valley fever coccidioidomycosis or valley fever (vf) is a fungal zoonosis affecting humans and a variety of animal species. in this study, we used texas veterinary medical diagnostic laboratories (tvmdl) data of all dog sera tested for coccidioidomycosis from july 1999 december 2009. census data on human population density for texas were used to determine the dog population density and identify disease clusters for the 5,871 submitted dog sera over a period of 10.5 years. both the isopleth map of the vf seropositive rates in dogs across texas and the identified spatial and spatio-temporal clusters of the disease suggested that vf occurs in the western and southwestern part of texas at a much higher rate than in other areas of the state (2). since vf is not a reportable disease in tx, dogs could be used as a sentinel for human infection. results the above studies illustrate the utility of gis as a tool in integrating different ecological factors to understand disease occurrence and spread. the geographical and temporal patterns found in these studies provide benchmark to support disease control activities in texas. additionally, the identification of high-risk areas may be useful for decision makers to improve and prevent future disease spread. conclusions spatial epidemiological research has challenges, such as dealing with coarse level and aspatial datasets. testing laboratories provide limited spatial information up to the zip code level due to the confidentiality concerns. spatial analysis of such dataset prevents research at finer resolutions (census block or block group). despite these limitations, spatial epidemiology continues to be an invaluable field in the research and surveillance of infectious disease. keywords geospatial analysis; disease mapping; environmental variables references 1. auchincloss ah, gebreab sy, mair c and diez roux av. a review of spatial methods in epidemiology, 2000–2010. annu. rev. public health. 2012; 33:107-22. 2. gautam r, srinath i, clavijo a, szonyi b, bani-yaghoub b, et al. identifying areas of high risk of human exposure to coccidioidomycosis in texas using serology data from dogs. zoonoses and public health. article first published online: 1aug,2012 *indumathi srinath e-mail: isrinath@webmail.cvm.tamu.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e129, 2013 public health/health information exchange (hie) collaborative public health/ health information exchange collaborative: a model for advancing public health practice 1 journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 public health/ health information exchange collaborative: a model for advancing public health practice charles magruder, centers for disease control and prevention (cdc) in early 2007, senior leadership in cdc’s new office of surveillance, epidemiology and laboratory services (osels) examined ways to improve biosurveillance capabilities in collaboration with public and private partners. after careful consideration, it was determined that many key aspects of surveillance could be enhanced through health information exchange (hie) interactions. approximately one year later in february 2008, cdc awarded three 1-year contracts (with options for 4 additional years) to address this area through an initial focus on current public health priorities, such as pandemic influenza. although only three sites were selected to become public health/hie collaboratives, the high number of qualified applicants indicated tremendous potential for future growth. the initial awardees were diverse in many ways. for example, one collaborative proposed development of an hie system in a community of about 500,000 people in washington state, while another focused its efforts on a large, metropolitan area in indiana. the third collaborative proposed development of a statewide hie in new york that would include several communities of varying sizes. in addition, the lead partner for each is different—representing the private sector, a not-for-profit research institute, and a state health department, respectively. from its inception, osels has worked collaboratively with various programs at health and human services (hhs), including the office of the national coordinator for health information technology (onc). in addition, osels has been committed to promoting the appropriate use of health it standards and providing the support needed to launch critical demonstration projects. at the same time, osels is focusing on issues that are unique to cdc and working with the biosurveillance coordination unit and other internal cdc departments. further, osels coordinates its activities with state and local health authorities in the areas supported by the public health/hie collaborative and encourages other partners, such as the association of state and territorial health officials, the council of state and territorial epidemiologists, and the national association of city and county health officials, to participate in these efforts. in a relatively short time, the collaborative have made great strides in supporting a variety of hhs and cdc initiatives and objectives. for example, an assessment of minimum biosurveillance data set acquisition capability has been completed, and plans to address shortcomings have been developed. in addition, an implementation guide for managing and transporting these data was created in accordance with mandated health information technology standards panel (hitsp). some unanticipated deliverables have been produced through this process as well. for example, the regenstrief institute, the coordinator of the indiana public health/hie collaborative, demonstrated a natural language processor for electronic laboratory reports, a breakthrough that could reduce costs and increase the amount of useable data received. public health/ health information exchange collaborative: a model for advancing public health practice 2 journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 in addition, osels has strengthened its collaborative efforts with other federal agencies, working closely with hhs’s office of science and data policy to develop a more comprehensive evaluation process. osels also continues to make progress in demonstrating various aspects of the biosurveillance use case, showcasing advances in public health practice that are possible with hie collaboration. in december 2008, osels successfully demonstrated its capabilities in this area at an hhs nationwide health information network conference in washington, dc. a few months later at a healthcare information and management systems society meeting, osels demonstrated its ability to use appropriate standards to transmit deidentified, aggregated data from individual health care sources through the hie to state and local health departments. once the data were analyzed at the local and state levels, these were sent to cdc for further analysis from a national perspective. subsequently, cdc used the resulting national trend data to quickly send out public health alerts to appropriate areas of the country. thus, osels demonstrated a functional, bidirectional communication process; one in which population data can be assessed quickly and important information can be released quickly to public health and health care practitioners. in august 2009, osels completed another demonstration at the phin conference interoperability showcase. in this scenario, osels emphasized new capabilities that were developed to support h1n1 influenza surveillance activities, including a new, standardized format for h1n1 surveillance called the geocoded interoperable population summary exchange (gipse). in september 2009, the public health/hie collaborative began using the gipse format to send h1n1 influenza data to cdc. currently, the members of the collaborative are working together to modify the gipse format to address new h1n1 influenza challenges identified by cdc and epidemiologists working in state and local health departments. foremost among these challenges is the need to develop a severity index. at the same time, each member is working on new initiatives that can be supported by hie collaborations, including enhancements in case reporting, development of a quality use case to address chronic diseases, enhanced alerting capabilities, and development of new biosurveillance formats for other infectious diseases. even at this early point in the process, there is sound evidence to substantiate this investment. osels will continue to work to improve its preparedness capabilities at local, state, and federal levels and to strengthen its basic infrastructure to support other medical and public health activities. charles magruder, md, mph medical epidemiologist center for disease control (cdc) national center for public health informatics 1600 clifton road ms e-68 atlanta, ga usa 30047 email: zgu4@cdc.gov mailto:zgu4@cdc.gov layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts risk and protective factors for arthritis status and severity masaru teramoto*1, fred breukelman2, ferdinando a. gatto2 and sheniz moonie3 1health sciences, drexel university, philadelphia, pa, usa; 2delaware health and social services, dover, de, usa; 3university of nevada, las vegas, las vegas, nv, usa objective to examine how cigarette smoking, alcohol consumption, obesity, and physical activity are associated with the risk and severity of arthritis among adults living in delaware. introduction research has indicated several risk and protective factors for arthritis, including cigarette smoking, alcohol consumption, obesity, and physical activity (1–4). however, it is not well understood how all these factors interact to increase/decrease the risk of arthritis. methods data from the 2009 delaware behavioral risk factor surveillance system (brfss) were analyzed in the current study. potential risk and protective factors for arthritis status and severity examined in this study included: smoking status, alcohol consumption, weight status, and physical activity level. weighted percentages were calculated for the risk and protective factors by arthritis status and activity limitation due to arthritis/joint symptoms, and were analyzed using a raoscott !2 test. a logistic regression analysis was performed to determine an odds ratio (or) while adjusting for gender, age, race/ethnicity, and education. results adults living in delaware self-reporting arthritis were more likely to be former and current smokers than those without self-reported arthritis (p < 0.001, or = 1.64–1.70). moderate and heavy alcohol drinking was associated with lower prevalence and severity of arthritis (p < 0.001, or = 0.45–0.74). there was a significant relationship between obesity and arthritis status or activity limitation due to arthritis/joint symptoms (p < 0.01, or = 1.62–2.14). furthermore, people with arthritis having activity limitation due to arthritis/joint symptoms were more likely to not meet the current physical activity recommendations (5) (p = 0.013, or = 1.49). conclusions cigarette smoking, alcohol consumption, obesity, and physical activity are all associated with the prevalence and severity of arthritis. it is possible that smoking and obesity have a negative impact on the risk and severity of arthritis, whereas alcohol consumption and physical activity may reduce its risk and severity. further research, including prospective cohort studies, is necessary to determine the true absolute risk of developing arthritis, so that we can design the effective prevention strategies. table 1. risk and protective factors by arthritis status and severity notes: values given as % (se). anot overweight/obese: < 25.0 kg/m2, overweight: 25.0–29.9 kg/m2, obese: " 30 kg/m2. bmoderate physical activity for " 30 minutes/day on " 5 days/week, or vigorous physical activity for " 20 minutes/day on " 3 days/week (5). *rao-scott !2 test. keywords alcohol; smoking; arthritis; behavioral risk factor surveillance references 1. albano sa, santana-sahagun e, weisman mh. cigarette smoking and rheumatoid arthritis. semin arthritis rheum 2001; 31:146–159. 2. maxwell jr, gowers ir, moore dj, et al. alcohol consumption is inversely associated with risk and severity of rheumatoid arthritis. rheumatology 2010; 49:2140–2146. 3. anandacoomarasamy a, caterson i, sambrook p, et al. the impact of obesity on the musculoskeletal system. int j obes 2008; 32:211–222. 4. manninen p, riihimaki h, heliovaara m, et al. physical exercise and risk of severe knee osteoarthritis requiring arthroplasty. rheumatology 2001; 40:432–437. 5. haskell wl, lee im, pate rr, et al. physical activity and public health: updated recommendation for adults from the american college of sports medicine and the american heart association. circulation 2007; 116:1081–1093. *masaru teramoto e-mail: masaru.teramoto@drexel.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e179, 2013 layout 1 the international society for disease surveillance held its eleventh annual conference in san diego on december 4th and 5th, 2012, under the theme expanding collaborations to chart a new course in public health surveillance. during these two days, practitioners and researchers across many disciplines gathered to share best practices, lessons learned and cutting edge approaches to timely disease surveillance. a record number of abstracts were received, reviewed and presented – the schedule included 99 orals, 4 panels, 94 posters, 5 roundtables and 12 system demonstrations. presenters represented 24 different countries from africa, north and south america, europe, and asia . topics covered included, but were not limited to, statistical methods for outbreak detection, border health, data quality, evaluation of novel data streams, influenza surveillance, best practices and policies for information sharing, social network analysis, data mining techniques, surveillance during weather events and mass gatherings, syndrome development, and novel uses of syndromic surveillance data. there were also discussions on the impact of regulations and standards development on disease surveillance, including meaningful use and the international health regulations. the 2012 conference was also host to several exciting keynote and plenary talks, including those given by james fowler, professor of medical genetics and political science at the university of california, san diego and bill davenhall, global manager of esri's health and human service solutions group. plenary speakers steve waterman, centers for disease control and prevention (cdc); simon hay, university of oxford; and brian mccloskey, health protection agency in london, reflected on the importance of effective collaborations in their respective topics of migrant and border health, malaria disease epidemiology and mass gathering health. national and international representatives from the cdc, the world health organization and the department of homeland security also discussed their respective strategic plans for disease surveillance. in addition, the 2012 data visualization event enabled conference attendees to collaborate and gain knowledge of visualization tools and techniques applied to a rich, de-identified set of ambulatory electronic health record (ehr) data. participants developed visualizations of chronic disease events using this common data set and presented their work during the evening poster session. the goals for this event were to demonstrate and share visualization tools and techniques that attendees could learn to apply to their own data and also to provide exposure to data elements available in ambulatory ehr systems and highlight their potential for surveillance and research. my hope is that attendees of the 2012 isds conference strengthened existing collaborations and fostered new ones, and returned to their places of work or study energized with new ideas and approaches to disease surveillance. the challenge for all of us is to sustain this new energy throughout the coming year and to leverage the tools available to us to share best practices and reach out for assistance when needed. we all want to improve the health of our populations, and collaborations will enable us to achieve that goal. a. ising carolina center for health informatics, department of emergency medicine, school of medicine, university of north carolina at chapel hill, chapel hill, nc, usa; 2012 isds scientific program committee chair isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts 2012 international society for disease surveillance conference expanding collaborations to chart a new course in public health surveillance online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e1, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts detecting the determinants of health in social media caitlin rivers*1, bryan lewis1 and sean young2 1network dynamics and simulation science laboratory, virginia bioinformatics institute, blacksburg, va, usa; 2ucla david geffen school of medicine, berkley, ca, usa objective create an analysis pipeline that can detect the behavioral determinants of disease in the population using social media data. introduction the explosive use of social media sites presents a unique opportunity for developing alternative methods for understanding the health of the public. the near ubiquity of smartphones has further increased the volume and resolution of data that is shared through these sites. the emerging field of digital epidemiology[1] has focused on methods to analyze and use this “digital exhaust” to augment traditional epidemiologic methods. when applied to the task of disease detection they often detect outbreaks 1-2 weeks earlier than their traditional counterpart [1]. many of these approaches successfully employ data mining techniques to detect symptoms associated with influenza-like illness [2]. others can identify the appearance of novel symptom patterns, allowing the ability to detect the emergence of a new illness in a population [3]. however, behaviors that lead to increased risk for disease have not yet received this treatment. methods we have created a methodology that can detect the behavioral determinants of disease in the population. initially we have focused on risky behaviors that can contribute to hiv transmission in a population, however, the methodology is generalizable. we collected 15 million tweets based on 32 broad keywords relating to three types of risky behaviors associated with the transmission of hiv: drug use (e.g. meth), risky sexual behaviors (e.g. bareback), and other stis (e.g. herpes). we then hand coded a subset of 2,537 unique tweets using a crowd-sourceable “game” that can be distributed online. this hand-coded set was used to train a simple n-gram classifier, which resulted in an algorithm to select relevant tweets from the larger database. we then generated geocodes from text locations provided by the tweet author, supplemented by the ~1% of tweets that are already geolocated. we scaled these geocodes to the state and county levels, which allowed us to compare hiv prevalence in our collected data with public health data. results we present the correlation between behaviors identified in social media and the corresponding impacts on disease incidence across a large population. hand coding revealed that 34% of tweets with one or more of the 32 initial keywords was relevant to behaviors associated with hiv transmission. among the three categories of initial search terms, the drug category yielded 21% true positives, compared to 9% for risky behaviors, and 2% for other stis. the n-gram classifier measured 66% sensitivity and 44% specificity on a test set. in addition, our geolocation algorithm found coordinates for 88% of text locations. of those, a test sample of 59 text locations showed that 83% of geolocations are correctly identified. these components combine to form an analysis pipeline for detecting risky behaviors across the united states. conclusions we present a surveillance methodology to help sift through the vast volumes of these data to detect behaviors and determinants of health contributing to both disease transmission and chronic illness. this effort allows for identification of at-risk communities and populations, which will facilitate targeted, primary and secondary-prevention efforts to improve public health. keywords social media; hiv/aids; digital epidemiology acknowledgments we thank our external collaborators and members of the network dynamics and simulation science laboratory (ndssl) for their suggestions and comments. this work has been partially supported by: nih midas grant 2u01gm070694-09 and dtra cnims contract hdtra1-11-d-0016-0001 references [1] salathé, m., bengtsson, l., bodnar, t. j., brewer, d. d., brownstein, j. s., buckee, c., campbell, e. m., et al. (2012). digital epidemiology. (p. e. bourne, ed.)plos computational biology, 8(7), e1002616. doi:10.1371/journal.pcbi.1002616 [2] achrekar, h., lazarus, r., & park, w. c. (2011). predicting flu trends using twitter data. the first international workshop on cyber-physical networking systems (pp. 713–718). [3] neill db. fast bayesian scan statistics for multivariate event detection and visualization. stat med. 2011feb.28;30(5):455–69. *caitlin rivers e-mail: cmrivers@vbi.vt.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e161, 2013 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts influenza study of backyard animals in georgia anna machablishvili*1, lela ursuhadze1 and ivane daraselia2 1national center for disease control and public health, tbilisi, georgia; 2tbilisi zoological park, tbilisi, georgia objective the purpose of this study was to identify zoonotic influenza viruses in swine and poultry populations in georgia and to define their pandemic potential. introduction aquatic birds are the main reservoirs of influenza viruses, however pigs represent an essential host in virus ecology as they are susceptible to both avian and human influenza viruses. circulating zoonotic influenza (a/h7n9, a/h5n1, and a/h3n2v) viruses could mutate into forms easily transmissible from human-to-human and become a public health concern. georgia is located along routes used by migrating birds where different species of aquatic birds are found. in 2006, highly pathogenic influenza virus a/h5n1 was detected in two wild swans in adjara (western georgia). moreover, in the frame of wild bird surveillance, various subtypes of influenza a viruses were detected in mallard and gulls in georgia (lewis, 2013). thus domestic animals in georgia have a potential chance to contract influenza viruses from wild birds. methods the kakheti region, the leading region in cattle breeding and poultry production in georgia, was selected for study. villages were selected for door-to-door visits to search for ill backyard animals showing influenza-like symptoms. in case of identification of a sick animal, samples were obtained for laboratory investigations; sample collection forms were filled out to generate epidemiological data. cloacal and tracheal swabs were taken from poultry; and pharyngeal and nasal swabs were collected from pigs. each specimen was screened for influenza a matrix gene by real-time rt-pcr using a protocol from the centers for disease control prevention. results eighty four villages in the kakheti region were surveyed for domestic animals with influenza-like illness symptoms. in total, 164 specimens were collected from 112 backyard animals in 55 households (107 samples were from 55 poultry and 57 samples were from 57 pigs). all samples tested negative for influenza a virus by real time rt-pcr. the questionnaire data revealed that the age range of both pigs and poultry varied from one month to two years; median and mode were both 1 year. chickens and ducks primarily freely ranged in backyards (67%), while half the number of pigs were kept in closed premises. equally, 61% of pigs and poultry had contact with other pigs or poultry within the premises. conclusions in spite of the negative findings, we cannot exclude the circulation of influenza viruses in domestic animals in georgia. especially, considering the fact that a domestic duck with influenza a/h10 virus was identified during veterinarian training in 2010 in grigoleti (black sea cost of georgia) manifesting no clinical symptoms. therefore, larger scale studies, including swabbing more backyard animals without any clinical symptoms are necessary to identify interspecies virus transmission in the country. keywords zoonotic influenza; pigs; poultry; georgia acknowledgments funding to conduct this study was provided by crdf georgia mini grant #60211. participation in this conference was made possible by financial support provided by the us defense threat reduction agency. the findings, opinions and views expressed herein belong to the authors and do not reflect an official position of the department of the army, department of defense, or the us government, or any other organization listed. references lewis ns, et al. (2013). avian influenza virus surveillance in wild birds in georgia: 2009–2011. plos one 8(3): e58534. doi:10.1371/ journal.pone.0058534 *anna machablishvili e-mail: a_machablishvili@hotmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e155, 2017 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts determinants of outbreak detection performance nastaran jafarpour*1, doina precup2 and david buckeridge2 1department of computer engineering, ecole polytechnique de montreal, montreal, qc, canada; 2mcgill university, montreal, qc, canada objective to predict the performance of outbreak detection algorithms under different circumstances which will guide the method selection and algorithm configuration in surveillance systems, to characterize the dependence of the performance of detection algorithms on the type and severity of outbreak, to develop quantitative evidence about determinants of detection performance. introduction the choice of outbreak detection algorithm and its configuration can result in important variations in the performance of public health surveillance systems. our work aims to characterize the performance of detectors based on outbreak types. we are using bayesian networks (bn) to model the relationships between determinants of outbreak detection and the detection performance based on a significant study on simulated data. methods the simulated surveillance data that we used was generated by surveillance lab of mcgill university using simulation analysis platform [1] considering surveillance in an urban area to detect waterborne outbreaks due to the failure of a water treatment plant. we focus on predicting the performance of the c-family of algorithms, because they are widely used, state-of-art outbreak detection algorithms [2]. we investigate the influence of algorithm characteristics and outbreak characteristics in determining outbreak detection performance. the c1, c2, and c3 are distinguished by the configuration of 2 parameters,the guardband and memory. generally, gradually increasing outbreaks can bias the test statistic upward, so the detection algorithm will fail to flag the outbreak. to avoid this situation, the c2 and c3 use a 2-day gap, guardband, between the baseline interval and the test interval. the c3 includes 2 recent observations, called memory, in the computation of the test statistic. the w2 algorithm is a modified version of the c2 which takes weekly patterns of surveillance time series into account [3]. in the w2, the baseline data is stratified to 2 distinct baselines: one for weekdays, the other for weekends. the w3 includes 2 recent observations of each baseline while calculating the test statistic in the corresponding baseline. we ran the c1, c2, c3, w2, and w3 on 18k simulated time series and measured the sensitivity and specificity of detection. then we created the training data set of 5400000 instances. each instance was the result of performance evaluation of an outbreak detection algorithm with a specific setting of parameters. in order to investigate the determinants of detection performance and reveal their effects quantitatively, we used bn to predict the performance based on algorithm characteristics and outbreak characteristics. results we developed 2 bn models in the weka machine learning software [4] using 5-fold cross-validation. the first bn determines the effect of the guardband, memory, alerting threshold, and the weekly pattern indicator (0 for c-algorithms, 1 for w-algorithms) and outbreak characteristics (contamination level and duration) on the sensitivity of detection. the value of sensitivity was mapped to 4 classes: (0, 0.3], (0.3, 0.6], (0.6, 0.9], (0.9, 1]. the developed bn correctly classified 67.74% of instances. the misclassification error was 0.9407. the second bn for predicting the specificity of detection correctly classified 95.895% of instances in 10 classes and the misclassification error was 0.2975. conclusions the contamination level and duration of outbreaks, alerting threshold, memory, guardband, and whether the weekly pattern was considered or not influence the sensitivity and specificity of outbreak detection and given the c-algorithm parameter settings, we can predict outbreak detection performance quantitatively. in future work, we plan to investigate other predictors of performance and study how these predictions can be used in algorithm and policy choices. keywords outbreak detection; public health surveillance; machine learning; bayesian networks; detection performance references 1.buckeridge, d.l., et al. simulation analysis platform (snap): a tool for evaluation of public health surveillance and disease control strategies. 2011. american medical informatics association. 2.hutwagner, l., et al., the bioterrorism preparedness and response early aberration reporting system (ears). journal of urban health: bulletin of the new york academy of medicine, 2003. 80(supplement 1): p. i89-i96. 3.tokars, j.i., et al., enhancing time-series detection algorithms for automated biosurveillance. emerging infectious diseases, 2009. 15(4): p. 533. 4.hall, m., et al., the weka data mining software: an update. acm sigkdd explorations newsletter, 2009. 11(1): p. 10-18. *nastaran jafarpour e-mail: nastaran.jafarpour@polymtl.ca online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e90, 2013 design principles in the development of (public) health information infrastructures 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 design principles in the development of (public) health information infrastructures roderick neame 1 1 university of queensland, qld 4072, australia abstract in this article the author outlines the key issues in the development of a regional health information infrastructure suitable for public health data collections. a set of 10 basic design and development principles as used and validated in the development of the successful new zealand national health information infrastructure in 1993 are put forward as a basis for future developments. the article emphasises the importance of securing clinical input into any health data that is collected, and suggests strategies whereby this may be achieved, including creating an information economy alongside the care economy. it is suggested that the role of government in such developments is to demonstrate leadership, to work with the sector to develop data, messaging and security standards, to establish key online indexes, to develop data warehouses and to create financial incentives for adoption of the infrastructure and the services it delivers to users. however experience suggests that government should refrain from getting involved in local care services data infrastructure, technology and management issues. key words: regional information management infrastructure design principles introduction public health strategies aim to improve population health and quality of life by reducing the incidence of avoidable illness, unnecessary morbidity and premature mortality: this can be achieved by analysis and identification of threats and hazards to health, as well as by early identification and containment of new syndromes and epidemics. in order to achieve these goals, it is necessary to monitor patterns of disease and of care in order to identify health priorities, to research causes of clusters of diseases and to accumulate evidence about which interventions are effective in different clinical situations. obtaining the data to support these vital functions can be difficult, especially where there is a need for near real time data to identify health hazards (such as failing implants) and monitor the spread/patterns of epidemics – all in the context of a budget that typically demands more to be delivered using less resources. data on which to make such judgements may be difficult to obtain: quality and timely data even harder. even the most basic data on what services are purchased/ provided with public funding can be difficult to obtain, so making quality, timely and cost-effective health business decisions almost impossible. even more elusive is data on the reasons for care decisions, and the outcomes of treatments. data about care services provided is generally design principles in the development of (public) health information infrastructures 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 abstracted by clerks (not by those directly involved in the care encounter) and compiled into summaries and mandatory data returns, but the quality of these data often leaves much to be desired: the degree of separation between the clinical encounter and the coder reporting on it leaves room for extensive misunderstanding and misinterpretation – not to mention simple errors of abstraction and coding. data abstracted from records by clerks, even in the best environments, is often of insufficient quality to meet the demands placed upon it 1 . in addition the inherent delay in reporting may be inconsistent with the needs for real time surveillance of risks: many public health reports are more than 1 year old when released, and real time data is scarce. there is a volume published by the world health organisation on improving health data quality 2 which contains much useful material on the topic. however it starts from a palpably false assumption, which is that everyone, including clinical staff, is dedicated to the production of high quality coded data about each and every care event and encounter. few clinicians are even remotely interested in servicing the needs of public health information: their priorities are with the care of their patients, the enhancement of their personal diagnostic and therapeutic acumen, their research interests (if any) and their professional standing and, last but not least, their remuneration. even so, clinical input is essential in providing the high quality data required for public health purposes and this presents a real challenge. there is plenty of analysis as to why data quality may be poor, and prominent amongst the factors is the lack of clinician involvement as well as poor working arrangements between clinical, ward, records and coding staff. poor quality data is reassuring, but falsely so, since it tells a story that is materially different from what exists and is happening in the field. the absence of data may be ‘better’ than poor data, simply because it does not falsely reassure, and does not divert attention from issues that are actually priorities. the us institute of medicine reports that many care errors and adverse incidents occur as a result of poor data and information 3 ; but more than that, poor quality data increases costs as well as preventing measurement of performance, impeding research and analysis, and obstructing quality assurance 4 . ways forwards there are four significant considerations that provide ways of taking things forwards. each is briefly outlined below. information economy: quality information suffers from being seen as an ‘add-on’ to the main activity and services for which the provider is paid. as such, it appears to lack importance and status, and this is reflected in its management at every point: the minimum possible effort is invested in reporting the data, since it is not ‘worth’ enough for anyone to pay for it. it is self-evident that quality data has a value: the logic is to separate the information about care services provided into a separate ‘economy’ which recognises the value of quality information as an entity separate from the care services themselves, and rewards those who provide it. therefore consider splitting the payments due to those providing care services into 2 parts: one part would be for providing the service(s) to the patient; the other part would be for the provision of timely, accurate and auditable data on the reasons for and clinical data associated with the provision of the care service(s). these fees can be adjusted relative to each other in order to secure the required result. where providers fail to furnish the required information within the allowed time period about the service(s) provided, they will receive only one part of the total potential fee. http://library.ahima.org/xpedio/groups/public/documents/ahima/bok1_047417.hcsp?ddocname=bok1_047417#notes design principles in the development of (public) health information infrastructures 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 as soon as there is a financial incentive associated with the provision of quality clinical information, one of the main obstacles is overcome: the development of an information economy where there are profits to be made will rapidly spawn new services designed to supply that need, and will assure the interest of clinicians. the financial incentives for information will drive the adoption of information management systems which can provide the required data automatically and quickly. this investment in information systems will create a marketplace where value added services provided by private enterprise will become very attractive. feeding back information derived from data collections is often an invaluable aid to establishing the value of data and information: such information can help drive efficiencies, promote effectiveness, reveal poor performance, identify areas of risk and generally improve competitiveness and services delivery. local valued resources: there are information resources that are carefully maintained at a local level because they support the needs of staff working with those patients: where information resources are valued by local staff, the information they contain will be accurate and validated. the key, therefore, is to access these data in order to generate the data required for public health purposes. for the most part the ‘key’ resource is the medical record, and it is from this document that clerks attempt to abstract data for required returns. increasingly medical records are moving towards being held electronically in point-of-care systems, and this makes abstracting public health data automatically relatively easy. so supporting the development of electronic medical records is a priority for public health: and ensuring that any public health data developments that take place are entirely consistent with the implementation of electronic records systems is a priority. developing a ‘public health information system’ that are incompatible with electronic medical records, whether these are introduced earlier or later, would be absurd. data aggregation: the crucial issue is to ensure that data collected from different sources is able to be aggregated. for that to happen, there must be agreed data definitions (what each term means), agreed classifications and codings and agreed data sets to be provided in respect of each reportable situation so that the data from one encounter can be combined with the same data from many other encounters and locations. whilst the temptation to develop ‘new’ classification and coding systems is ever present, the disadvantages of this are so extensive that the idea should be rejected out of hand. the critical element in planning a health information infrastructure lies here. each healthcare enterprise that implements information management technology that suits its needs can be seen as an ‘island of technology’. those islands can be structured in many different ways using open or proprietary applications, classifications, codings, interfaces, messages and data definitions – and it has often been to the advantage of vendors to make their systems proprietary and base them on their own ‘in-house standards’. joining up these islands is the critical challenge, and for this there has to be a clear specification of how they will be joined at technical connectivity as well as data exchange levels. the technical connectivity has been effectively by-passed since the industry has found ways of linking all types of systems because of the commercial pressure to enable linking into the internet. the remaining issues relate to data: definitions, classifications, coding, sets, messages etc; these are where the effort has to be invested to create an infrastructure that can join the islands together, irrespective of how they function internally. design principles in the development of (public) health information infrastructures 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 public health data warehouse: the value in any data collection will only emerge when large quantities of quality data are aggregated into a warehouse that supports sophisticated analysis. much of the current analysis of the data is based on hypothetico-deductive research: an hypothesis is developed and the data is used to support or refute that hypothesis – which is the way research has been carried out for decades. the problem is in the nature of the hypotheses that are developed and tested: because of human cognitive limitations, the hypotheses tend to be relatively simplistic, deterministic and boolean, of the form “if sign a positive, and test b positive, and medication c negative, then diagnosis d”. however medicine is increasingly revealing itself to be based on relationships and associations which are more multi-factorial, fuzzy and probabilistic – none of which humans find comfortable to work or hypothesise with, although they present no problems for computers. developments in data warehousing and mining, driven mainly by commercial and retail interests, provide the technology for intelligent systems to analyse large data collections to identify patterns and associations that were previously unsuspected and/or unrecognised. the capacity to ‘drill down’ into the data warehouse allows these associations to be explored in greater detail. even where there is no apparent scientific reason or explanation for a cluster of data with various common factors and data associations, the fact that it exists, and is statistically significant, is important in its own right and may suggest new avenues for study and research, and ultimately for prevention and treatment. health information infrastructure implementations in 1993 the first national health information infrastructure went live in new zealand (nzhis). some 18 years later a far bigger health information infrastructure for the uks national health service, was formally abandoned in 2011. the similarities and differences between these are useful as a basis for deriving some design and development issues and principles. 1. new zealand the nzhis 5 was the first such national health information infrastructure: the author was chief government consultant for design, development and implementation. the system cost less than usd$5million, which was recouped in less than 1 year from retirement of legacy systems and services; there was a 2 year development period. the stated aims of the system were to support financial accountability in the context of the separation of funder and provider roles (previously funds were disbursed to providers without knowing what was being purchased), to facilitate and promote information integration between primary and secondary care, to support the national public health agenda and to allow non-government service providers and health care plans/insurers to compete for public funds and offer alternative services to the community. a prime focus of the system was to support the public health agenda. the system was designed to gather the data required to identify community health needs, evaluate health policy, allocate resources equitably, monitor service quality and performance, and meet reporting obligations. strong emphasis was placed on an open and contestable architecture, where a key parameter was the specification of standards for data and connectivity which were developed to act as a guide to service providers in their information systems procurements. the system created an online national healthcare user index 6 , a personal care summary (conditions, treatments, warnings and immunisations etc) accessible to authorised users from any location, and a minimum data set defined and to be collected for each design principles in the development of (public) health information infrastructures 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 secondary care event. the event data was copied to the funding agency for payment management. a major emphasis was placed on data privacy, and on explaining to all parties how their data was protected: this involved legally binding agreements with users and telcos, encryption, and robust data pseudonymisation. a detailed review of the goals and focus of the system was published contemporaneously 7 . since that time there have been many enhancements of that system, some initiated by government, and others by the private sector. the emphasis on data and communication standards promoted the implementation of electronic records systems and services. the nonproprietary nature of the infrastructure, together with its emphasis on standards, created a viable marketplace and encouraged many third party technology providers to offer enhanced services compatible with and leveraging off that system. ultimately the nzhis was disestablished in 2008 having fulfilled its developmental purpose: its functions and services were distributed amongst other government departments who took on responsibility for their operation and maintenance (eg user and practitioner indices, data warehouses, classification, terminology and data dictionary services etc). 2. uk the uk nhs national program for it (‘connecting for health’ cfh)was initiated in 2005, and was formally terminated in 2011 following a formal audit 8 which revealed an unacceptable pattern of delays, performance problems, and extensive professional concerns as to whether the plan was deliverable. the system cost somewhere in excess of £10billion. the aims of the system were to provide patients with more choice and control, to provide better information for patients and clinicians and thereby to deliver better care, to reduce the risks associated with care, and to provide quality information for secondary uses, especially public health. the core planned services included delivery of electronic records (ehr) systems with detailed care records held locally and summary care records held centrally/nationally on ‘the spine’, applications for online booking of referrals (‘choose and book’ c&b) and electronic prescribing (eps), picture communications (pacs), as well as some improvements to connectivity with greater security (virtual private network vpn) and an nhs email directory service. the spine system was intended to act as the records repository and therefore as the main resource for individual identification and those services depending upon it, as well as being the data warehouse for encounter/event reports and payments management. the plan was divided up into two parts: national services (eg the ‘spine’, the vpn and email services etc) and the local services. for the local services, a small number of local implementation service providers (lisps) were identified, each of whom was contracted to create a system and deliver it to institutions within an allocated geographic region, so giving the end users no choice in the systems available to them – other than to decline to accept them. the cfh data privacy plan was seen as flawed from its inception and was brought into question by several experts 9,10 . in broad terms it can be seen that the core goals and the national services of this system were congruent with those of the nz system outlined above – that is to create a central data repository, with online patient and provider indices, and online access to key personal health information, as well as a set of standards for data and communications. however the uk plan extended into additional areas, such as ehr, pacs, eps, c&b, and what amounts to an nhs vpn: these were areas that the nz system deliberately left blank to enable institutions to choose those services they valued (in the light of the nationally defined data and design principles in the development of (public) health information infrastructures 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 communications standards), and to permit private enterprise to devise, develop and market such services. phii design and development principles the crucial requirement at a functional level is that the system should make possible the aggregation of data within a common data structure and format – in other words that the same terms mean the same thing to all those connected to the system, and that there is a common format for aggregation of data, including data classification and coding and the sets of data to be collected. at the same time this infrastructure enables the exchange of data ‘sideways’ between care providers and enterprises – the only difference being that there must be common standards for a wider range of data elements as well as a wider range of sets of data to be exchanged (eg tests and investigation requests and reports, administrative data on admissions, separations, transfers, pharmacy prescriptions, discharge summaries, entire electronic records exchange etc). there is no fundamental difference between the infrastructure required for data collections for public health purposes, and for data exchanges between providers: and it is vital to ensure that ‘public health’ data is not seen as different in any way, nor is it developed separately from ‘general’ health data. government, as the coordinator and principal source of funds, has a vital role to play in making this happen. government must show initiative and leadership in setting standards (with the relevant professionals) in respect of the data sets to be exchanged, the message structures and formats by which they will be exchanged, the data classification and codings, and the data definitions. almost all of this already exists in various repositories: however there are often several alternatives that could be used, and the sector as a whole needs to decide which to select for their purposes, and where there may be alternatives, options or deficiencies that need to be managed. this creates the vital piece which enables the various parts of the health sector to communicate, but it does not impose on them any requirement as to how they manage their own data internally within their ‘island’: that said it soon becomes clear that in order to make best use of the infrastructure, there are some internal data infrastructures that will align better with the external infrastructure than others. it is here that the core information systems development principles become most relevant. these are based on the guiding principles formulated at the inception of the nzhis project 7 and followed throughout its implementation. 1. the system should facilitate integration of personal health records horizontally between service providers as well as aggregation vertically to ‘higher levels’ in the system, including summaries of care and preventive records as well as current personal clinical alerts and warnings (eg significant conditions and risks, important current treatments and medications) 2. the system should be based as far as possible on an open and contestable architecture and messaging infrastructure, with standards for data and communications clearly specified: proprietary systems and services should be used only where there is no practicable alternative, and even then the proprietary restrictions should be negotiated away as far as possible. 3. the communications environment should be specifically selected to facilitate and encourage third party providers to develop value-added services on top of the basic design principles in the development of (public) health information infrastructures 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 and national services developed by government. 4. local information systems are the province of local management and should be selected by local management and clinicians to meet and support their needs: the ‘centre’ (health department, government etc) should be at all times aware that stepping over the threshold and becoming involved in the choice and operation of local systems greatly enhances the risk of failure where all problems can be laid at the feet of government interference, irrespective of their cause. 5. government must take on the key role of managing the online healthcare users and providers indexes, and of promulgating (with proper consultation) data definitions, data sets and messaging standards so facilitating information aggregation and exchange; but government must refrain from developing clinical or administrative systems or imposing choices on institutions as to what systems to select and how to manage them. 6. information privacy and systems security are not only an ethical imperative but a legal obligation, and an issue of the highest sensitivity: it must therefore be planned as an integral element of all systems and services ensuring the highest level of ethical acceptability, and these plans opened to public scrutiny. in particular the use of robust identification of staff/users and patients is essential; and robust pseudonymisation (see below) of all personalised data used for purposes other than clinical (inclusive of payment and audit). 7. all users must be enabled to connect with the system at minimal cost and with the minimum of barriers to entry, irrespective of the brand, size and platform of the internal systems they have chosen, and using the services of their own it systems providers/support: this generally means development of a free basic api (applications program interface) that can be run on any platform, but can be fully integrated into systems as and when users decide to do so. 8. honest and open explanations of the needs, purposes and solutions being adopted, and especially the approach to privacy and security, should be disseminated widely in formats designed for the different categories of individuals (health professionals, administrators, lay public etc). bridges of common understanding need to be built between government and health professionals, as well as with strategic community groups. 9. incentives for using the systems need to be incorporated. where government funds care services, payments can be linked to provision of data, and speed of payment can be linked to the speed with which data is provided. the unique national patient identifier can be required to substantiate all basic claims for payment; the prescribed minimal data set relevant to the clinical situation can be required to support claims lodged electronically for the full payment; and electronic reimbursement can be made the same day as claims are received and validated. 10. updates to data definitions, sets, classifications and coding systems, message definitions etc must be negotiated with the sector and published some considerable time ahead of their mandatory introduction, so that institutions, their it services and systems developers have sufficient time to incorporate these into local systems. design principles in the development of (public) health information infrastructures 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 as a brief observation, it would seem that the uk nhss cfh project definitely adhered only to principle 1 above: it seems likely that it breached principles 8 and 10 above, and it is clear that it breached principles 2 – 7. principle 9 is probably irrelevant in the context of the operational management of the nhs. phii benefits and risks the benefits from a phii development are twofold. one benefit is that information can be exchanged between providers caring for the same patient, improving continuity and integrity of care, and allowing patients to choose where they go for care services, rather than being ‘locked-in’ to an institution which holds their medical records. the other main benefit is the aggregation of data into warehouses that permits all types of cross-sectional and longitudinal studies to be undertaken to analyse incidence of diseases/syndromes, immunisation and prevention status, best care practices, previously unknown associations between entities, etc. all of this will become invaluable as the progressive move is made into greater use of artificially intelligent decision support and alerting systems, which rely heavily on a comprehensive and up-to-date knowledgebase derived from the evidence that is abstracted from the data warehouses. there is a potential risk to patient information privacy. all data passing across public networks can be protected from eavesdropping by strong encryption, using a technology appropriate to the risk, but migrating progressively towards a secure public key infrastructure (pki) encryption environment. for the most part it is quite unnecessary for the identity of the patient to be attached to data used for research purposes: the personal identifying elements can be replaced with a cipher, a process sometimes known as ‘pseudonymisation’. this is effective only where it is robust, and there is no ready access to enable users to re-establish the identity of the individual – although as in the nzhis a ‘key in escrow’ arrangement can be made so that in the event of, for example, a serious problem being identified that could threaten the well-being of individuals (eg a faulty implant), a decision can be made at top level to apply the key solely to re-identify those affected and advise their care provider(s) of the potential risks. information feedback the value of health information and evidence lies in making use of it to improve community health status, to inform and educate both clinicians and patients, and to get the best possible value for every health dollar that is spent. generating data is all well and good: but using it effectively is vital. the research shows that those providing data do so more willingly and conscientiously if they get something back from their efforts, so feeding back useful information to the workface is all important. tables of statistics for many people have little impact: graphic representations of the data (pie-charts, histograms etc) often mean much more to the recipients of the information, and it is only if they understand the data that they will look to modify their behaviour appropriately. timely data is the most useful, so providing updates on current outbreaks of disease and on newly identified syndromes is vital. most competitive services welcome comparative feedback identifying strengths, weaknesses and opportunities for improvement. the use of charts which place the performance of each service provider/unit in the context of the performance on the same parameters of all similar service units (all being anonymised), gives design principles in the development of (public) health information infrastructures 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 a clear idea of where there is cause for concern as well as for self-congratulation. crucially as cost-effectiveness becomes the new driving force in health service delivery, it will be vital to compare unit performance based on their adherence to best practice guidelines and on overall costs for each clinical entity. timely feedback is essential. where feedback is delayed, bad results can and usually are dismissed as out-of-date and ‘changes have already been made’ to improve performance. the goal must be real time feedback preferably whilst the patient is still in care identifying those individuals where care costs are out of control, and clinical parameters/outcomes are sub-optimal so that lessons can be learned before it is too late. but it is just as important to engage the community in this feedback process, alerting them individually and as a community to risks and hazards, to better and worse performing care service units, to epidemics, to the need for appropriate preventive care and much more. patients have to make informed decisions about their own health and the way in which they can make best use of the available services: they can only do this if they are well informed about risks and options. where technology is less advanced the impact of this sort of approach on care service providers depends on the level of technology they have access to. those with no automation, not even an office computer, will be able to provide their data for an initial period on paper forms – but this should be phased out with incentives to move to a higher level of technology. where there is basic office automation – just a computer connected to the internet – providers will be able to use the free api to submit the required data in support of their claims for payment. those with more advanced systems will be able to use the infrastructure specifications to have their it staff develop an interface between their systems and the api to enable fully automatic submission of data and claims. systems developers and providers will have a clear information infrastructure definition to guide their development of next generation systems. it is vital that the full set of required data elements for each clinical situation are collected within the software and coded using the agreed classification and coding system in order for the link between the systems and api to be easy to engineer. once the infrastructure has been clearly specified, and there is a clear marketplace, it does not take long for entrepreneurs to identify a range of value-added commercially viable services that can be developed for health sector users, compatible with the infrastructure and offering further performance enhancements and benefits to users, so effectively further embedding the use of these systems in the sector. in this way the relatively small investment of the government in infrastructure leads to a much larger investment by the private sector in an expansion of the environment. conclusion public health information management must be developed as part of a general health information management strategic plan: they need to be developed side-by-side to ensure complete consistency and compatibility. strategies need to be implemented that can engage the interests of clinicians in the provision of quality, timely information: associating the provision of information with financial incentives is suggested. design principles in the development of (public) health information infrastructures 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 privacy concerns always emerge as a key issue in such information infrastructures and the data repositories associated with them. both longitudinal and cross-sectional research studies can be conducted on pseudonymised data without any breach of personal privacy, although maintaining a decryption key-in-escrow may be a wise precaution. data warehouses and their tools for data mining will bring considerable added value to the data collections, and analysis using neural networks will quickly identify patterns and association in the data that human analysis cannot readily discern. these data collections will be invaluable in determining best quality practices and providing the knowledgebase for artificially intelligent systems in healthcare. feeding back information abstracted from such analysis to those providing the information, as well as to the public, will be important in ensuring the continuing cooperation of clinicians and patients alike, and in ensuring practitioner adherence to best quality care protocols. distilling down the 10 principles outlined above, the big issues, based on a wealth of practical experience, appear to be: that the issue of personal information privacy protection, both relating to patients and to care providers, is addressed thoroughly and planned for meticulously in the context of both the law and highest ethical principles, and laid open to public scrutiny that government takes a leadership role and defines the required standards for data interchange (data and messages), as well as creating the requisite ‘back-end’ services to support the system (eg online identifiers, data collections/warehouses etc) – all based on open and non-proprietary standards, and with minimal barriers to adoption and use that government does not impose systems or services on clinical service providers and enterprises, thereby infringing their autonomy, but having defined the infrastructure and created incentives for its use, then leaves commercial vendors to develop and market value-added services that leverage off that infrastructure. limitations the 10 principles outlined above have been derived empirically: there may be others that are equally relevant, but have not yet been identified; and the 10 that have been outlined will likely benefit from further refinement and modification. because of the size, complexity and expense of such major projects, however, it is difficult to envisage that there will be many experiments conducted specifically to test the principles. however it may be that where such infrastructures are being planned and developed, those involved may reflect on the principles, decide in advance which to adopt and which to dismiss, and subsequently review their progress, and difficulties, in the light of these principles. some of these same principles might be applicable to the many smaller (eg enterprise wide) systems integration projects that arise as enterprises acquire new facilities and seek to integrate them into their existing care and billing infrastructure. however for the most part these projects tend to revolve around pragmatic decisions as to how to extend existing systems (good or bad) to embrace new members, rather than exploring how best to link together multiple islands of technology each of which has as much merit as the next, and at the same time to develop the resources required for the ‘public good’ that support better management of public health. design principles in the development of (public) health information infrastructures 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 conflicts of interest: none correspondence roderick neame, ba,ma,phd,mb,bchir,fachi health information consulting ltd, 16 glen eden court, flaxton, qld 4560, australia email: roddyneame@hic-ltd.com references 1. bruce s. audit commission criticises data quality. ehealth insider, 16 april 2009 http:// www.ehi.co.uk/news/ehi/4756 2. improving data quality: a guide for developing countries. world health organisation, geneva isbn 92 9061 0506 http://www.wpro.who.int/nr/rdonlyres/73a68297b5be-42d3-83ca-d5a00468b2b4/0/improving_data_quality.pdf 3. institute of medicine. to err is human: building a safer health system. washington, dc: national academy press, 2000 4. 2006. ahima e-him workgroup on ehr data content. "data standard time: data content standardization and the him role. j ahima. 77(1), 26-32. 5. new zealand health information service. new zealand ministry of health, wellington http:// www.nzhis.govt.nz/moh.nsf/indexns/about 6. johnston j, neame rlb. (1994) a national on-line population-based index of healthcare consumers: issues and insights from the new zealand experience. proceedings of medical informatics europe (mie 94) (may 22-6) lisbon 320-327 7. neame r, johnston j. developing a national health information network: insights from experiences in new zealand. proceedings of hc94 (march 1994), harrogate, 503-509; and international journal of bio-medical computing, volume 40, issue 2, pages 95-100, october 1995 http://www.journals.elsevierhealth.com/periodicals/ijbold/article/0020-7101%2895% 2901131-w/pdf 8. the national programme for it in the nhs. an update on the delivery of detailed care records systems. national audit office, london may 2011 http://www.nao.org.uk/publications/1012/ npfit.aspx 9. sturcke j, campbell d. nhs database raises privacy fears, say doctors. the guardian sunday 7 march. http://www.guardian.co.uk/society/2010/mar/07/nhs-database-doctors-warning 10. neame r. 2008. privacy and health information: health cards offer a workable solution. inform prim care. 16(4), 263-70. http://www.ehi.co.uk/news/ehi/4756 http://www.wpro.who.int/nr/rdonlyres/73a68297-b5be-42d3-83ca-d5a00468b2b4/0/improving_data_quality.pdf http://www.wpro.who.int/nr/rdonlyres/73a68297-b5be-42d3-83ca-d5a00468b2b4/0/improving_data_quality.pdf http://www.nzhis.govt.nz/moh.nsf/indexns/about http://www.journals.elsevierhealth.com/periodicals/ijbold/issues?issue_key=s0020-7101%2800%29x0002-5 http://www.journals.elsevierhealth.com/periodicals/ijbold/article/0020-7101%2895%2901131-w/pdf http://www.journals.elsevierhealth.com/periodicals/ijbold/article/0020-7101%2895%2901131-w/pdf http://www.nao.org.uk/publications/1012/npfit.aspx http://www.guardian.co.uk/society/2010/mar/07/nhs-database-doctors-warning http://www.guardian.co.uk/society/2010/mar/07/nhs-database-doctors-warning http://www.ncbi.nlm.nih.gov/pubmed/19192327 the geographic distribution of mammography resources in mississippi 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi the geographic distribution of mammography resources in mississippi elizabeth n. nichols1, denae l. bradley1, xu zhang2, fazlay faruque3 and roy j. duhé4 1. murrah high school, jackson, ms 39216, usa. 2. center of biostatistics & bioinformatics, university of mississippi medical center, jackson, ms 392164505, usa. 3. gis & remote sensing program, university of mississippi medical center, jackson, ms 39216-4505, usa. 4. department of pharmacology and toxicology & department of radiation oncology, university of mississippi medical center, jackson, ms 39216-4505, usa. abstract objective: to determine whether the availability of mammography resources affected breast cancer incidence rates, stage of disease at initial diagnosis, mortality rates and/or mortality-to-incidence ratios throughout mississippi. methods: mammography facilities were geocoded and the numbers of residents residing within a thirty minute drive of a mammography facility were calculated. other data were extracted from the mississippi cancer registry, the u.s. census, and the mississippi behavioral risk factor surveillance survey (brfss). results & discussion: there were no statistically-significant differences between breast cancer incidence rates in black versus white females in mississippi; however, there were significant differences in the use of mammography, percentages of advanced stage initial diagnoses, mortality rates, and mortality-to-incidence ratios, where black females fared worse in each category. no statistically-significant correlations were observed between breast cancer outcomes and the availability of mammography facilities. the use of mammography was negatively correlated with advanced stage of disease at initial diagnosis. by combining black and white subsets, a correlation between mammography use and improved survival was detected; this was not apparent in either subset alone. there was also a correlation between breast cancer mortality -to-incidence ratios and the percentage of the population living below the poverty level. conclusions: the accessibility and use of mammography resources has a greater impact on breast cancer in mississippi than does the geographic resource distribution per se. therefore, intensified mammography campaigns to reduce the percentage of advanced-stage breast cancers initially diagnosed in black women, especially in communities with high levels of poverty, are warranted in mississippi. key words: breast cancer; mammography; health disparities; geographic information system (gis) correspondence: rduhe@umc.edu doi: 10.5210/ojphi.v5i3.4982 copyright ©2014 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in t he copy and the copy is used for educational, not-for-profit purposes. http://ojphi.org/ the geographic distribution of mammography resources in mississippi 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi introduction breast cancer is the most frequently-occurring cancer in women; fortunately, breast cancer mortality rates have steadily declined in the united states since 1990 [1,2]. this decline appears to have resulted from the combined benefits of the increased use of screening mammography a nd adjuvant therapy. however, improvements in breast cancer survival have not been uniform in all populations and in all geographic regions throughout the nation. most notably, despite their lower incidence rates for breast cancers, black women die from these diseases at higher rates than do white women, and this trend has persisted for many years [3]. given that approximately 37% of mississippians are of african ancestry, the disparate outcomes affecting african american women may have a significant impact on mississippi's cancer burden. an important aim of this study is to compare cancer outcomes between black and white female mississippi residents and to explore the possible reasons for the differential outcomes. however, there are other demographic characteristics of particular relevance to mississippi, and these too may result in a worsened overall impact due to breast cancer mortality rates. relative to the other states in america, mississippi has one of the lowest levels of educational attainment [4] and lowest rates of high school graduation [5]. mississippi has chronically ranked as one of the poorest states in the usa, whether measured by childhood poverty rates [6], median household income 1 or by percentage of the population living below poverty level [7]. it has been well-documented that low socio-economic status (ses) parameters such as literacy and income [8,9] are generally associated with higher cancer mortality rates, and this is also true for breast cancer mortality rates [10]. to better understand how ses parameters can affect breast cancer mortality rates, much research has been invested in understanding the relationships between ses and specific aspects of health care consumption and delivery. this is a complicated issue, and these relationships may not be preserved in all geographic locations, because health care systems are subject to regional variations. in fact, some studies suggest that, although early-stage cancers are less likely to be detected in poor areas due to decreased mammography rates, this has no overall bearing on breast cancer survivorship [11]. some aspects of racial disparity are difficult to understand. for example, maly and co -workers described a pronounced disparity in the diagnostic delay between black women and white women with breast cancer, regardless of whether their breast abnormalities were initially selfdetected or detected by health care providers [12]. a study conducted with a south carolina cohort also found racial disparities in the interval time between the first abnormal clinical breast examination and determination of final status in economically-disadvantaged black versus white women, although there was no significant disparity associated with overall completion of mammographic work-up [13]. it is unclear why such delays should be greater for black women with breast cancer than for comparable white women. in addition to the socio-economic factors that might contribute to racial disparities in breast cancer outcomes, one must also consider the influence of biological factors contributing to these disparities. there are a variety of breast cancer subtypes which can be distinguished by their gene expression profiles, and these subtypes correlate with differing clinical outcomes [14,15]. for example, patients with the luminal a breast cancer subtype have very good survival prospects, and approximately 90% of such patients can expect to be long-term survivors. in contrast, patients with the basal-like breast cancer subtype have the least favorable survival odds, and may not survive longer than four years post-diagnosis. the immunohistochemical tools http://ojphi.org/ the geographic distribution of mammography resources in mississippi 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi routinely used by clinical pathology laboratories to verify the presence of estrogen receptor α, progestin receptor b and her2/neu (human epidermal growth factor receptor 2) have been useful in identifying major breast cancer subtypes in patients. the luminal a and b subtypes both express estrogen receptor α, for example, which indicates that these tumors may respond to endocrine therapy with aromatase inhibitors or selective estrogen receptor modulators (serms). her2 amplification and overexpression is a significant diagnostic feature which indicates that a tumor may respond to trastuzumab, lapatinib or pertuzumab therapy. the basal-like breast cancer subtype, in contrast, often presents with an immunohistochemically "triple-negative" phenotype, i.e., these breast cancers lack immunoreactivity for estrogen receptor α, progestin receptor b and do not contain genomic amplification of her2/neu. basal-like tumors can be treated with chemotherapy, but a substantial fraction of these tumors respond poorly to therapy and have a poor prognosis. over a decade has passed since five breast cancer subtypes (luminal a, luminal b, normal -like, basal-like and her2-enriched) were first identified by distinctive gene expression profiles, and during that interval much has been learned about how these subtypes may contribute to the population-based disparities in breast cancer mortality. it is now well-established that not all populations possess an equal distribution of these subtypes. recently, genome-wide association studies identified a common risk variant for er-negative breast cancer on chromosome 5p15, and the allele frequency of this variant was nearly twice as high in women of african ancestry as it was for women of european ancestry [16]. “triple-negative” breast cancers [tnbc] themselves are a highly heterogeneous group that may include up to 6 different subtypes (basal like 1, basal-like 2, mesenchymal, mesenchymal stem-like, immunomodulatory and androgenreceptor enriched) that respond differently to treatment [17,18]. it is still unknown whether these subtypes are differently distributed among different ethnic groups. tnbcs are disproportionately observed in women of african ancestry. this observation has been corroborated in numerous u.s. studies, including those based on the california cancer registry [19,20], the carolina breast cancer study [21,22], a thomas jefferson university hospital cohort [23] and the seer database [23]. the high prevalence of these aggressive cancers in women of african ancestry is a worldwide phenomenon and is clearly rooted in biological diversity. in one study the prevalence of "triple-negative" breast cancers in ghanian women was reported to be a s high as 82% versus a 16% prevalence in american women of european ancestry [24]. while the prevalence of triplenegative/basal-like breast cancer is clearly higher in women of african versus european ancestry, it appears that the prognosis for survival may be equally grim for women of all races and ethnicities afflicted by this aggressive cancer subtype, but only when patient cohorts are properly matched for other factors that affect survival [25,26]. in addition to research that focuses on tnbc breast cancer subtypes, other research has investigated other possible biological explanations of population-based breast cancer mortality disparities. one group has observed more extensive cpg island methylation in the promoters of the rassf1a, rarβ2 and cdh13 loci in tumors taken from women of african versus european ancestry [27]. methylational silencing of tumor suppressor genes commonly occurs through such mechanisms. since these authors also observed an association between worse overall survival and higher methylation in these loci, they suggested that their discovery would be consistent with a biological explanation of disparity [27]. http://ojphi.org/ the geographic distribution of mammography resources in mississippi 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi as stated earlier, a major factor in the national decline in breast cancer mortality has been the increasing use of screening mammography. based on this evidence [28], the u.s. preventive services task force (uspstf) recommended mammography screening every 1 to 2 years for women age 40 years and older in 2002 [29]. in 2009, however, the uspstf recommended against routine mammography screening for women age 40 – 49, and they also recommended against clinicians teaching women how to perform breast self-exams [30]. these changes in uspstf recommendations were not without controversy, and several responses and rebuttals to the 2009 uspstf recommendations have been noted. despite the new uspstf recommendations, the majority of primary care physicians favor aggressive mammography screening of women from ages 40 to 79 [31]. the american cancer society continues to advise average-risk women to begin mammography screening at age 40, and they also recommend clinical breast exams every three years for women between the ages of 20 to 39 [32]. however, mammography is a capital-intensive diagnostic procedure, and in a poor (relative to u.s. standards) rural state such as mississippi, it may be difficult for all women to have easy access to mammography facilities. one should bear in mind that there are two aspects to be considered: availability and accessibility. resource availability refers to the physical presence of that resource; because all mammography facilities must be certified by the u.s. f.d.a, one can literally map mammography availability throughout the state. resource accessibility refers to the ability of a given individual to use that resource; this can be a much more complex aspect to quantify because it encompasses socioeconomic barriers to use, such as transportation to the resource, ability to pay for resource use, etc. in this manuscript we examine publicly-accessible data concerning breast cancer in mississippi to determine whether the geographic distribution of mammography facilities has a discernible effect on breast cancer outcomes in the state. the hypothesis to be tested is that limited availability of mammography facilities limits the accessibility of these resources, which results in an increased advanced stage at initial diagnosis and increased breast cancer mortality. methods spatial analysis spatial analysis in this project involved delineating areas within 30-minute drive time distance from the mammography facilities and then identifying demographic characteristics within and outside the drive time areas by apportioning data from census block groups. a spreadsheet for mammography facilities with data from the u.s. food and drug administration's mammography facility database (http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmqsa/mqsa.cfm) was prepared to geocode using arcgis 10.1 (environmental systems research institu te, inc., redlands, california). a map was created showing the location of the geocoded facilities along with the counties and major transportation network in mississippi (figure 1). using the same gis software areas within and outside the drive time distance in respect to all mammography facilities were identified based on optimum driving route. since facilities from neighboring states that are within the desired drive time distance (30 minute) can serve mississippians, facilities from all neighboring states were taken into account for this analysis (figure 2). this drive time distance area was also used to calculate the % female outside the desired distance from the mammography facility per public health district in mississippi (table 2). the delineated areas http://ojphi.org/ the geographic distribution of mammography resources in mississippi 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi were superimposed on census geography (block group) to proportionately apportion the demographic data from census geography to drive time distance area geography. demographic attributes were obtained from the 2010 u.s. census data. mcr breast cancer data breast cancer incidence and mortality data were obtained from the mississippi cancer registry (http://mcr.umc.edu/) over the years 2005 through 2009 to provide a more reliable "snapshot" of recent cancer statistics in a state dominated by low population density areas. mississippi has a fairly stable population, as evidenced by u.s. census data showing that the 0.3% change in population in mississippi from 2010 to 2011 was below the national average of 0.9%, and population changes for individual mississippi counties ranged from -3.0% to 3.2%. breast cancer data were derived from only the female cohort because mammography is not a recommended screening modality for males. mississippi's behavioral risk factor surveillance system (brfss) public health district survey report (http://msdh.ms.gov/brfss/index.htm) was the source of data on the use of mammography in women aged 40 and above were obtained from the district reports for the years 2005, 2006 and 2008 (this question is not annually included in the brfss). data analysis histograms were constructed for the cancer outcome, mammography usage and socio -economic variables to examine the normality of the distributions. correlation analysis was performed between cancer outcome variables and mammography usage or socio-economic variables to assess the degree of association. the pearson correlation coefficient was evaluated when both variables were normally distributed. if one variable or both variables had skewed distribution, the spearman rank correlation coefficient was utilized. comparison of cancer outcome variables between black and white women residents was performed using the two-sample t test. all p values were two-sided and p values less than 0.05 were considered significant. statistical analysis was performed using the software sas (version 9.3, sas institute inc.). results the gis mapping of fda certified mammography facilities in mississippi is shown in figure 1. the densest clustering of mammography facilities was located along major interstate highways. for example, thirteen mammography facilities were on the i-10 corridor that passes through hancock, harrison and jackson counties along the gulf coast, whereas there was only one mammography facility not adjacent to an interstate highway in the three count ies (pearl river, stone and george counties) immediately to the north. interstate-55 and interstate-20 intersect in jackson, mississippi, and there were sixteen mammography facilities in the tri -county region (hinds, madison and rankin counties) which defines the greater jackson metropolitan area. in addition to these sixteen facilities, there were seven on i-55 north, four along i-55 south, two on i-20 west and five on i-20 east. five additional mammography facilities were found along the i 59 corridor through jones, forrest, lamar and pearl river counties. thus, of the ninety fdacertified mammography facilities in mississippi, 52 (57.8%) were located along the interstate highway system. http://ojphi.org/ the geographic distribution of mammography resources in mississippi 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi figure 1. map of fda-certified mammography facilities in mississippi. the u.s. food and drug administration mammography facilities database was searched to identify the geographic address of all 90 mammography facilities in mississippi. these are shown as red crosses on the map, which contains references to the 82 counties of mississippi and the interstate highway system. (http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmqsa/mqsa.cfm) we then sought to estimate how many mississippi women had convenient access to these facilities, assuming that all women had equal access to automobile transportation. using the arcgis 10.1 software package (environmental systems research institute, inc., redlands, california), we calculated the drive time area in which a driver could travel to a mammography facility within thirty minutes for each facility. these 30-minute drive time areas for mississippi and its neighboring states are shown in green and purple in figure 2. because women who live http://ojphi.org/ the geographic distribution of mammography resources in mississippi 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi near the state border might choose to travel to mammography facilities outside of mississippi, we also calculated these 30-minute driving buffer areas for mammography facilities in the neighboring states louisiana, arkansas, tennessee and alabama which are shown in purple. by integrating the land areas covered within these buffer areas, one can see that 54% of mississippi was within a thirty minute drive to a mammography facility. in comparison, 58% of louisiana, 43% of arkansas, 76% of tennessee and 71% of alabama were situated within a thirty minutes' drive time to a mammography facility. figure 2. geographic availability of mammography facilities within a thirty-minute driving radius. this map displays the area that can be reached within a thirty-minute automobile drive from each mammography facility. the green buffer zone indicates areas surroundi ng mississippi-based facilities; purple buffers indicate areas surrounding facilities based in the surrounding states of louisiana, arkansas, alabama and tennessee. populations are not uniformly distributed, therefore the above percentages of land area within a thirty minute drive were not equivalent to the percentage of women living within those buffer areas. to determine the percentage of women who live within a thirty-minute drive to a mammography facility, we used 2011 estimated population data based on the 2010 u.s. census data. using these data, one can estimate that 84.10% of mississippi females of age 40 and above lived within a thirty minute drive to a mammography facility. in comparison, 94.36% of the females of age 40 and above in louisiana, 83.21% of those in arkansas, 94.50% of those in tennessee and 93.04% of the females in alabama resided within a thirty minutes' drive time to a mammography facility. thus, based on both the percentage of land area and the percentage of the female population within a thirty-minute driving area, mammography facilities in arkansas were slightly less available than they were in mississippi, and within this five-state territory, mammography facilities were most available in tennessee. these data are summarized in table 1. http://ojphi.org/ the geographic distribution of mammography resources in mississippi 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi table 1. geographic distribution of mammography facilities in mississippi and surrounding states. region alabama arkansas louisiana mississippi tennessee number of fda-certified mammography facilities 130 83 150 90 192 percentage of state territory within 30 minute drive to mammography facility 71% 43% 58% 54% 76% percentage of female residents within 30 minute drive to mammography facility 93.04% 83.21% 94.36% 84.10% 94.50% note: the data depicted in figure 2 are tabulated in table 1, along with the calculated territorial area and percentage of residents within a thirty-minute driving distance to a mammography facility. using such gis maps, one can assess whether breast cancer outcomes were correlated to the geographic distribution of mammography facilities throughout mississippi. considering that mississippi is a sparsely-populated, predominantly rural state with low population densities, there may be a problem of low statistical power if one uses too small of a geocoded area as the basis for comparison. thus, the first analysis was conducted at the level of mississippi's nine public health districts (phds). table 2 contains data derived from various sources which described certain aspects of the public health districts. the data of most interest are the percentages of females (age 40 and above) who reside outside of a thirty-minute drive to a mammography facility. using public data from the mississippi cancer registry, we examined the age-adjusted breast cancer incidence rates and the age-adjusted breast cancer mortality rates over the years from 2005 to 2009 for each of the state's phds. we were particularly interested in knowing whether the availability of mammography resources had a bearing on the breast cancer mortality-to-incidence ratio of the entire female population within these districts. we used this ratio to estimate the likelihood of surviving a diagnosis of breast cancer. the percentage of breast cancers initially diagnosed at an advanced stage (either regional or distant disease) was also considered as a potentially relevant outcome of limited availability of mammography resources. we applied pearson correlation analysis to the data in table 2 in pairwise fashion, but we were unable to detect any statistically meaningful correlations between any of these variables and http://ojphi.org/ the geographic distribution of mammography resources in mississippi 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi breast cancer mortality rates or mortality-to-incidence ratios when applied to the entire female population. however, the analysis revealed a significant negative correlation between the percentage of women who reported having mammography and clinical breast exams and the percentage of women who initially presented with advanced disease at the time of their initial diagnosis. the pearson sample correlation coefficient is -0.671 with a p value of 0.047 (95% ci 0.917 to 0.030). both the brfss data concerning mammography usage and the mississippi cancer registry data concerning stage of disease at initial diagnosis are available as black and white subsets, and we therefore re-examined these data accordingly and plotted them in figure 3 (upper panel). it was immediately apparent that the data describing the black population (blue dots) was distinctly different from the data describing the white population (red crosses) for all nine public health districts (table 2). this was confirmed by applying the two-sample t test to phd-level data, which showed that four characteristics were significantly different between the black and white female subpopulations: 1) the percentage of advanced-stage breast cancers detected at initial diagnosis (40.8% in black women vs. 31.5% in white women; p <0.0001); 2) the percentage of females age 40 and older who had mammography and clinical breast exams (73.13% in black women vs. 82.57% in white women; p = 0.0001); 3) the age-adjusted breast cancer mortality rate (33.38 per 100,000 in black women vs. 20.16 per 100,000 in white women; p = 0.0003); and 4) the breast cancer mortality-to-incidence ratio (0.2442 in black women vs. 0.1509 in white women; p = 0.0005). unfortunately, in all four of these characteri stics, black females fared worse than white females in mississippi, confirming that the extent of population -based breast cancer is pervasive throughout all nine phds in the state. only one characteristic was not statistically different, and that is the age-adjusted breast cancer incidence rate (p = 0.735). table 2. data characteristics of female breast cancer and breast cancer screening resources in mississippi's public health districts. region mammogr aphy facilities women per mammograph y facility ageadjusted breast cancer incidence rate (all female per 100,000; 2005-2009) ageadjusted breast cancer mortality rate (all female per 100,000; 20052009) breast cancer mortality -toincidenc e ratio % highstage (regional + distant) at diagnosis % females (age 40+) who had mammography & clinical breast exam % females (age 40+) beyond 30 minute drive to mammography facility mississippi 90 16900 134.96 24.27 0.1798 0.342 79.43% 15.88% northwest public health district 1 8 20384 130.70 24.73 0.1892 0.373 74.43% 15.44% northeast public health district 2 13 13927 130.97 24.83 0.1896 0.341 78.20% 11.65% http://ojphi.org/ the geographic distribution of mammography resources in mississippi 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi delta/hills public health district 3 7 16817 123.51 31.30 0.2534 0.368 74.87% 14.83% tombigbee public health district 4 8 15869 127.44 21.10 0.1656 0.338 79.27% 21.17% west central public health district 5 21 15696 155.31 24.82 0.1598 0.332 83.53% 11.68% east central public health district 6 8 15754 125.48 19.53 0.1556 0.362 78.63% 21.34% southwest public health district 7 5 18180 125.60 32.42 0.2581 0.367 80.93% 28.32% southeast public health district 8 5 31196 130.66 22.04 0.1687 0.335 81.23% 26.12% coastal plains public health district 9 15 15308 135.15 21.73 0.1608 0.310 81.03% 8.40% note: the characteristics listed in this table include the number of mammography facilities, the number of women per mammography facility, the age-adjusted breast cancer incidence and mortality rates, the mortality-to-incidence ratios, the percentage breast cancers initially diagnosed at advanced stage (regional + distant disease), the percentage of women (age 40 and older) who reported ever receiving a mammogram and clinical breast exam, and the percentage of women residing beyond a 30 minute driving distance from a mammography facilities in each of mississippi's public health districts. given the magnitude of these disparities, we performed correlation analyses on black and white subsets to determine whether the use of mammography in either black or white women was correlated to advanced stage at initial diagnosis for either group. the pearson correlation coefficient was -0.861 (p = 0.001, 95% ci -0.967 to -0.416) for black women, but did not reach statistical significance for white women, which reflects the more homogeneous use patterns amongst white women throughout the state. interestingly, when the black and white subsets were recombined, the common pearson correlation coefficient was -0.920 (p < 0.0001, 95% ci 0.968 to -0.783), indicating a strong correlation. only when the black and white subsets were recombined was it possible to observe a significant pearson correlation between the mortality-toincidence ratio and the percentage of women with advanced stage breast cancer at initial diagnosis (pearson coefficient = 0.771, p =0.0001, 95% ci 0.457 to 0.906). while no si gnificant correlation existed between mortality-to-incidence ratio and mammography use in either the black or the white subsets, a significant correlation (pearson correlation coefficient = -0.728, p < 0.0001, 95% ci -0.887 to -0.376) was observed upon recombination of these disparate subsets (fig 3, lower panel). http://ojphi.org/ the geographic distribution of mammography resources in mississippi 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi figure 3. public health district patterns of mammography use are inversely correlated with adverse breast cancer outcomes. mississippi brfss public health district survey report data (http://msdh.ms.gov/brfss/index.htm) from black female (blue dots) and white female (red crosses) respondents were obtained from the district reports for the years 2005, 2006 and 2008, then averaged and plotted along the abscissa. upper panel: the percentag e of women initially diagnosed with advanced stage breast cancer (defined as the sum of the percentages of regional and distant disease initial diagnoses over the years 2005 through 2009) calculated from mississippi cancer registry data for each of the nine public health districts http://ojphi.org/ the geographic distribution of mammography resources in mississippi 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi (http://mcr.umc.edu/documents/femalebreastphddatacombinedyears20052009new.pdf), then plotted against the ordinate. these black and white subsets were subjected to a common pearson analysis to obtain a correlation coefficient of -0.920 (p < 0.0001). lower panel: ageadjusted breast cancer incidence and mortality rates were obtained from the mississippi cancer registry (http://www.cancer-rates.info/ms/index.php) for black and white women over the years 2005 through 2009 for each of the nine public health districts, and the ratio of mortality-toincidence was calculated and plotted along the ordinate. the pearson correlation coefficient between these two variables was -0.728 (p < 0.0001). the observation shown in figure 3 is consistent with other published evidence that because ageappropriate mammography is capable of detecting early-stage breast cancer, broad usage of screening mammography can reduce the proportion of advanced-stage breast cancers at initial diagnosis [33]. the problem appeared to be most severe in the northwest public health district 1, where only 62% of black women age 40 and older reported ever having received mammography and clinical breast exam, and where 48% of the initial breast cancer diagnoses reveal advanced stage disease in black women. it is interesting to note that at the phd level, there was no statistically significant negative correlation between the percentage of women reporting mammography usage and the percentage of women who must drive more than thirty minutes to reach a mammography facility (pearson correlation coefficient = 0.119, p = 0.769). nor was there a statistically meaningful negative correlation at the phd level between the percentage of advanced-stage disease at diagnosis and the percentage of women who must drive more than thirty minutes to reach a mammography facility (pearson correlation coefficient = 0.413, p = 0.281). however, one must note that we were unable to distinguish between the geographic availability of mammography resources for black versus white women within any given geographic region, so we were unable to perform subset correlation analyses for this variable. thus, if there was any effect of the availability of mammography facilities on breast cancer outcomes, then our analysis was inadequate to detect this effect. it is reasonable to assume that by examining data at the public health district level, important demographic details may be hidden due to the homogenization of small geographic tracts with distinctive characteristics. using public data from the mississippi cancer registry, we further examined age-adjusted breast cancer incidence rates and age-adjusted breast cancer mortality rates over the years from 2005 to 2009 for all of the state's counties. even with this long time interval, data from issaquena county must be censored because that county's population is less than 1700; therefore issaquena county data will be excluded from further consideration. we initially applied spearman rank correlation analysis to determine whether, at the county level, either breast cancer incidence, breast cancer mortality, breast cancer mortality-to-incidence ratios or the percentage of advanced-stage breast cancers detected at initial diagnosis were associated to the percentage of females age 40 and above residing outside of a thirty-minute drive to a mammography facility. because this is the only variable with skewed distribution, the spearman rank correlation coefficient is a suitable criterion for association assessment. the spearman rank correlation coefficient for the association between the percentage of advanced-stage breast cancers detected at initial diagnosis and the percentage of females age 40 and above residing outside of a thirty-minute drive to a mammography facility was 0.208, but this association did not reach statistical significance (p = 0.063). thus, neither county-level data nor phd-level data can detect a statistically-significant association between the availability of mammography resources and stage of disease at initial diagnosis. further analysis of county level data reveals no http://ojphi.org/ the geographic distribution of mammography resources in mississippi 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi statistically meaningful correlation between the geographic availability of mammography facilities (as measured by the percentage of females residing outside of a thirty-minute drive to a mammography facility) and either breast cancer mortality rates (p = 0.681) or the mortality -toincidence ratios (p = 0.984). unfortunately, at the county level we lacked sufficient data (such as the brfss data) to measure the accessibility of mammography resources. when we looked for correlations between other potentially relevant parameters (% of population below poverty level, median household income, % high school graduates aged 25 and above, % black, and % white), two statistically-meaningful correlations were observed. there was a moderate correlation between breast cancer mortality-to-incidence ratios and the percentage of the population living below the poverty level (figure 4, lower panel). the pearson correlation coefficient for these two parameters was 0.504 (95% ci 0.318 to 0.649), with a p value of <0.0001. there was also a moderate correlation between breast cancer mortality rates and the percentage of the population who are black (figure 4, upper panel). the pearson correlation coefficient for these two parameters was 0.422 (95% ci 0.222 to 0.585), with a p value of <0.0001. it is very important to note that, in mississippi, the two parameters were strongly correlated. the pearson correlation coefficient between the percentage of black residents in a county and the percentage of the population in that county who live below the poverty level was 0.802 (95% ci 0.706 to 0.867), with a p value of = 0.0001. based on the breast cancer disparities between black and white women in mississippi observed in the preceding public health district data, cancer outcome comparison between black and white women using the county-level data may prove insightful. due to the rural nature of mississippi, data from several counties could not be considered in this subset analysis because the black or white population in those counties was less than 1700. therefore benton, choctaw, franklin, george, greene, hancock, issaquena, itawamba, perry, stone and tishomingo county data were excluded from the black female subset, and claiborne, jefferson, humphreys, issaquena, noxubee, quitman, sharkey, tunica and wilkinson county data were excluded from the white female subset. the two-sample t test was applied to county-level data, which confirmed that two characteristics were significantly different between the black and white female subpopulations: 1) the age-adjusted breast cancer mortality rate (p <0.0001) and 2) the breast cancer mortality-to-incidence ratio (p<0.0001). again, black females fared worse than white females in mississippi, confirming that the existence of significant population-based breast cancer mortality disparities in mississippi. as observed at the public health district level, the age-adjusted breast cancer incidence rate was not statistically different between black females and white females in mississippi (p = 0.735). http://ojphi.org/ the geographic distribution of mammography resources in mississippi 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi figure 4. county-associated parameters correlated with breast cancer mortality outcomes. breast cancer incidence and survival data were obtained from the mississippi cancer registry; demographic data were obtained from the u.s. census (http://quickfacts.census.gov/qfd/states/28000.html); all mississippi counties are represented, with the exception of issaquena county. upper panel: age-adjusted breast cancer mortality rates correlated with the percentage of the population who are black; the pearson sample correlation between these two variables was 0.422 (p <0.0001). lower panel: the ratios of bc mortality-to-incidence were correlated with the percentages of population living below poverty level; the pearson sample correlation between these two variables was 0.504 (p <0.0001). http://ojphi.org/ the geographic distribution of mammography resources in mississippi 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi county-level subset correlation analyses confirmed several of the observations at the phd level: there was no statistically-significant correlation between the availability of mammography resources (as measured by the % of women residing within a 30 minute drive to a mammography facility) and either the breast cancer incidence rate, the breast cancer mortality rate, or the mortality-to-incidence ratios for either the black female or the white female subsets. perhaps more importantly, the correlation between the percentage of population living below poverty level and the mortality-to-incidence ratio was observed for black females (pearson correlation coefficient = 0.346, p = 0.003, 95% ci 0.120 to 0.534), but surprisingly, not for white female subsets (p = 0.274). one must guard against over-interpretation of the latter observation because the "percentage of population living below poverty level" data were unadjusted for race and were determined at the county level. due to the low populations at risk, some of the counties with the highest percentage of residents living below the poverty level in mississippi (claiborne, jefferson, humphreys, noxubee, quitman, and sharkey counties) were excluded from the white female subset, which may have introduced bias against detecting the effect of poverty in this subset. conversely, some of the counties with the lowest percentage of residents living below the poverty level (george, stone and itawamba counties) were excluded from the black female subset, which may have introduced bias towards detecting the effect of poverty in this subset. this reflected of the strong correlation between race and poverty in mississippi; a pearson correlation coefficient of 0.802 (p<0.0001) exists between the percentage of population who are black and the percentage of population living below the poverty level. discussion one cannot properly assess the burden of breast cancer in mississippi without recognizing the problem of population-based disparities. this study initially sought to assess whether geographic disparities existed based on the statewide distribution of mammography facilities, but data analysis quickly revealed that poverty and race were the dominant characteristics affecting geographic disparities in breast cancer outcomes in mississippi. at the county level, the percentage of population below poverty level and the percentage of population who are black are strongly correlated. thus, it is apparent that breast cancer places a disparate burden on poor african-american communities in mississippi. this study was not designed to include direct measures of the impact of aggressive "triple-negative" breast cancer subtypes, so one can only assume that it contributes to the disproportionate mortality rates observed in black mississippians, as discussed in the introduction section. recent analysis of national breast cancer data confirm that poverty and race remain as dominant risk factors in breast cancer mortality and that screening rates are lower in poorer women than in wealthier women [33]. the data shown in figure 3 indicate that the proportion of advanced-stage breast cancers at initial diagnosis in african-american women could be significantly reduced throu gh a concerted campaign to increase the rate of participation in mammographic breast screening in african-american women in mississippi. a decrease in the proportion of breast cancers diagnosed at an advanced stage may affect not only mortality rates (the probability of long-term survival is strongly negatively correlated with stage), but also additional parameters. these include among others the cost and morbidity associated with treatment (advanced stage breast cancers that recur require additional chemotherapy, imaging and often salvage procedures such as spine stabilization, brain irradiation etc.). it is not entirely clear why there was no apparent correlation between the availability of mammography facilities and the use of mammography. further studies designed for the county level of geographic resolution, or in selected communities, may identify the community -specific http://ojphi.org/ the geographic distribution of mammography resources in mississippi 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi barriers to mammographic use, and hopefully these barriers can be overcome through community-targeted educational outreach campaigns. it has been estimated that 84 women between the ages of 40 and 84 need to be screened annually in order to save one life from breast cancer [34]. care must be taken to note that screening alone is inadequate in mississippi if the true objective is to increase breast cancer survivorship; women who receive positive screening results must also receive appropriate follow-up care. a proposal to increase breast cancer screening participation should address whether such an effort in mississippi would result in problems associated with overdiagnosis of breast cancer. by definition, overdiagnosis occurs through the detection of cancers that would not otherwise cause symptoms or death to occur within the lifetime of an individual [35]. overdiagnosis, by itself, can create needless emotional stress and anxiety considered harmful to a person's wellbeing, but the major harm associated with the overdiagnosis of breast cancer arises from overtreatment that often accompanies overdiagnosis. estimates for the overdiagnosis of breast cancer vary tremendously. a study of norwegian women estimated that approximately 15% to 25% of breast cancer cases were overdiagnosed [36], and estimates as high as 42% overdiagnosed breast cancers were obtained from an australian cohort [37]. studies reporting overdiagnosis predominantly involve european populations or populations of european ancestry, and are focused on ductal carcinoma in situ (dcis), a non-invasive form of breast cancer which ranges from low-grade to high-grade. although dcis is considered non-invasive, clinicians are currently unable to predict which specific cases of dcis are highly likely to progress, and which cases are likely to remain indolent and can be safely left untreated. the increasing frequency of routine mammography screening is considered to be the cause of the increasing diagnosis of dcis, which had an incidence of less than 2 per 100,000 women in the early 1970s and thirty years later, had an incidence of approximately 32 per 100,000 women [38]. approximately 1 in 1300 mammograms will result in a diagnosis of dcis [39], which accounts for approximately 20% to 25% of breast cancer diagnoses in the u.s.a. today [38]. however, there are no indications that overdiagnosis and overtreatment of breast cancer is currently a significant problem in mississippi, where the percentage of dcis at initial diagnosis is lower than the national average [33] and where the underuse of mammography appears to be linked to increased probability of mortality after diagnosis. conclusion as previously discussed, one cannot properly assess the burden of breast cancer in mississippi without recognizing the problem of population-based disparities. this study initially sought to determine whether the geographic availability of mammography resources influenced breast cancer outcomes, but data analysis quickly revealed that poverty and race were the dominant characteristics affecting geographic disparities in breast cancer outcomes in mississippi. the data presented in this manuscript supports two general observations pertaining to mississippi’s cancer control efforts. first, intensified mammography campaigns to reduce the percentage of advanced-stage breast cancers initially diagnosed in black women are justified and warranted. second, efforts are needed to ensure that once breast cancers are diagnosed, effective medical treatment will occur, especially for all women living in poverty. http://ojphi.org/ the geographic distribution of mammography resources in mississippi 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi limitations before discussing the above results, the following limitations of the study design should be noted. these studies were based on publicly available data, and as such, all health and economic data were analyzed in aggregate form. data were not obtained at the individual level, so the interpretations and implications of the evidence are limited to broadly defined localities and communities. out of respect for individual medical privacy, public cancer registry data are censored for statistically sparse counties, so some women with breast cancer were excluded from this study based on their place of residence (e.g., issaquena county). finally, to compensate for such problems associated with the low population density in many parts of mississippi, a five year data collection window was used based on the assumption that the recent trends in breast cancer outcomes have remained reasonably stable. acknowledgements the authors would like to acknowledge dr. robin rockhold and the base pair program for sponsoring science mentorship in central mississippi for over twenty years, and for providing numerous high school students with opportunities to design and conduct scientific research in a professional environment. the authors also acknowledge dr. donna sullivan, ms. gail howell and mr. jeffrey stokes for their essential roles in the base pair program, and they gratefully acknowledge the financial support of the base pair program (funded by the howard hughes medical institute). the authors gratefully acknowledge the advice and assistance of ms. deirdre rogers and data provided by the mississippi cancer registry. the helpful comments of dr. lucio miele and dr. marinelle payton are greatly appreciated. conflicts of interest rjd is a member of the advisory board of the mississippi cancer registry and the medical/research advisor to the mississippi partnership for comprehensive cancer control executive board. otherwise, the authors have no conflicts of interests to report. references 1. miller jw, king jb, joseph da, richardson lc. 2012. breast cancer screening among adult women-behavioral risk factor surveillance system, united states, 2010. mmwr morb mortal wkly rep. 61(suppl), 46-50. pubmed 2. berry da, cronin ka, plevritis sk, fryback dg, clarke l, et al. 2005. effect of screening and adjuvant therapy on mortality from breast cancer. n engl j med. 353(17), 1784-92. pubmed http://dx.doi.org/10.1056/nejmoa050518 3. van ravesteyn nt, schechter cb, near am, heijnsdijk ea, stoto ma, et al. 2011. race-specific impact of natural history, mammography screening, and adjuvant treatment on breast cancer mortality rates in the united states. cancer epidemiol biomarkers prev. 20(1), 112-22. pubmed http://dx.doi.org/10.1158/10559965.epi-10-0944 4. ryan cls. j. educational attainment in the united states: 2009. population characteristics. 2012;p20-566. http://ojphi.org/ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22695463&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16251534&dopt=abstract http://dx.doi.org/10.1056/nejmoa050518 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21119071&dopt=abstract http://dx.doi.org/10.1158/1055-9965.epi-10-0944 http://dx.doi.org/10.1158/1055-9965.epi-10-0944 the geographic distribution of mammography resources in mississippi 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi 5. aud s, hussar w, johnson f, kena g, roth e, et al. the condition of education 2012. (nces 2012-045) us department of education, national center for education statistics washington, dc. 2012. 6. macartney s. child poverty in the united states 2009 and 2010: selected race groups and hispanic origin. american community survey briefs. 2011;november 2011(acsbr/1005):1-16. 7. macartney sm, l. poverty and shared households by state: 2011. american community survey briefs. 2012;acsbr/11-05. 8. albano jd, ward e, jemal a, anderson r, cokkinides ve, et al. 2007. cancer mortality in the united states by education level and race. j natl cancer inst. 99(18), 1384-94. pubmed http://dx.doi.org/10.1093/jnci/djm127 9. du xl, lin cc, johnson nj, altekruse s. 2011. effects of individual-level socioeconomic factors on racial disparities in cancer treatment and survival: findings from the national longitudinal mortality study, 19792003. cancer. 117(14), 3242-51. pubmed http://dx.doi.org/10.1002/cncr.25854 10. sprague bl, trentham-dietz a, gangnon re, ramchandani r, hampton jm, et al. 2011. socioeconomic status and survival after an invasive breast cancer diagnosis. cancer. 117(7), 1542-51. pubmed http://dx.doi.org/10.1002/cncr.25589 11. schootman m, lian m, deshpande ad, baker ea, pruitt sl, et al. 2010. temporal trends in area socioeconomic disparities in breast-cancer incidence and mortality, 1988-2005. breast cancer res treat. 122(2), 533-43. pubmed http://dx.doi.org/10.1007/s10549-009-0729-y 12. maly rc, leake b, mojica cm, liu y, diamant al, et al. 2011. what influences diagnostic delay in lowincome women with breast cancer? j womens health (larchmt). 20(7), 1017-23. pubmed http://dx.doi.org/10.1089/jwh.2010.2105 13. adams sa, smith er, hardin j, prabhu-das i, fulton j, et al. 2009. racial differences in follow-up of abnormal mammography findings among economically disadvantaged women. cancer. 115(24), 5788-97. pubmed http://dx.doi.org/10.1002/cncr.24633 14. perou cm, sorlie t, eisen mb, van de rijn m, jeffrey ss, et al. 2000. molecular portraits of human breast tumours. nature. 406(6797), 747-52. pubmed http://dx.doi.org/10.1038/35021093 15. sørlie t, perou cm, tibshirani r, aas t, geisler s, et al. 2001. gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. proc natl acad sci usa. 98(19), 1086974. pubmed http://dx.doi.org/10.1073/pnas.191367098 16. haiman ca, chen gk, vachon cm, canzian f, dunning a, et al. 2011. a common variant at the tertclptm1l locus is associated with estrogen receptor-negative breast cancer. nat genet. 43(12), 1210-14. pubmed http://dx.doi.org/10.1038/ng.985 17. chen x, li j, gray wh, lehmann bd, bauer ja, et al. 2012. tnbctype: a subtyping tool for triplenegative breast cancer. cancer inform. 11, 147-56. pubmed http://dx.doi.org/10.4137/cin.s9983 18. lehmann bd, bauer ja, chen x, sanders me, chakravarthy ab, et al. 2011. identification of human triplenegative breast cancer subtypes and preclinical models for selection of targeted therapies. j clin invest. 121(7), 2750-67. pubmed http://dx.doi.org/10.1172/jci45014 19. amirikia kc, mills p, bush j, newman la. 2011. higher population-based incidence rates of triple-negative breast cancer among young african-american women: implications for breast cancer screening recommendations. cancer. 117(12), 2747-53. pubmed http://dx.doi.org/10.1002/cncr.25862 20. parise ca, bauer kr, caggiano v. 2010. variation in breast cancer subtypes with age and race/ethnicity. crit rev oncol hematol. 76(1), 44-52. pubmed http://dx.doi.org/10.1016/j.critrevonc.2009.09.002 http://ojphi.org/ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17848670&dopt=abstract http://dx.doi.org/10.1093/jnci/djm127 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21264829&dopt=abstract http://dx.doi.org/10.1002/cncr.25854 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21425155&dopt=abstract http://dx.doi.org/10.1002/cncr.25589 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20054637&dopt=abstract http://dx.doi.org/10.1007/s10549-009-0729-y http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21486163&dopt=abstract http://dx.doi.org/10.1089/jwh.2010.2105 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19859902&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19859902&dopt=abstract http://dx.doi.org/10.1002/cncr.24633 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=10963602&dopt=abstract http://dx.doi.org/10.1038/35021093 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11553815&dopt=abstract http://dx.doi.org/10.1073/pnas.191367098 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22037553&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22037553&dopt=abstract http://dx.doi.org/10.1038/ng.985 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22872785&dopt=abstract http://dx.doi.org/10.4137/cin.s9983 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21633166&dopt=abstract http://dx.doi.org/10.1172/jci45014 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21656753&dopt=abstract http://dx.doi.org/10.1002/cncr.25862 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19800812&dopt=abstract http://dx.doi.org/10.1016/j.critrevonc.2009.09.002 the geographic distribution of mammography resources in mississippi 19 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi 21. carey la, perou cm, livasy ca, dressler lg, cowan d, et al. 2006. race, breast cancer subtypes, and survival in the carolina breast cancer study. jama. 295(21), 2492-502. pubmed http://dx.doi.org/10.1001/jama.295.21.2492 22. o'brien km, cole sr, tse ck, perou cm, carey la, et al. 2010. intrinsic breast tumor subtypes, race, and long-term survival in the carolina breast cancer study. clin cancer res. 16(24), 6100-10. pubmed http://dx.doi.org/10.1158/1078-0432.ccr-10-1533 23. morris gj, naidu s, topham ak, guiles f, xu y, et al. 2007. differences in breast carcinoma characteristics in newly diagnosed african-american and caucasian patients: a single-institution compilation compared with the national cancer institute's surveillance, epidemiology, and end results database. cancer. 110(4), 876-84. pubmed http://dx.doi.org/10.1002/cncr.22836 24. stark a, kleer cg, martin i, awuah b, nsiah-asare a, et al. 2010. african ancestry and higher prevalence of triple-negative breast cancer: findings from an international study. cancer. 116(21), 4926-32. pubmed http://dx.doi.org/10.1002/cncr.25276 25. chu qd, henderson ae, ampil f, li bd. outcome for patients with triple-negative breast cancer is not dependent on race/ethnicity. int j breast cancer. 2012;2012:764570. 26. dawood s, broglio k, kau sw, green mc, giordano sh, et al. 2009. triple receptor-negative breast cancer: the effect of race on response to primary systemic treatment and survival outcomes. j clin oncol. 27(2), 220-26. pubmed http://dx.doi.org/10.1200/jco.2008.17.9952 27. wang s, dorsey th, terunuma a, kittles ra, ambs s, et al. 2012. relationship between tumor dna methylation status and patient characteristics in african-american and european-american women with breast cancer. plos one. 7(5), e37928. pubmed http://dx.doi.org/10.1371/journal.pone.0037928 28. nelson hd, tyne k, naik a, bougatsos c, chan bk, humphrey l. screening for breast cancer: an update for the u.s. preventive services task force. ann intern med. 2009;151(10):727-37, w237-42. 29. 2002. screening for breast cancer: recommendations and rationale. ann intern med. 137(5 part 1), 344-46. pubmed 30. screening for breast cancer: u.s. preventive services task force recommendation statement. ann intern med. 2009;151(10):716-26, w-236. 31. yasmeen s, romano ps, tancredi dj, saito nh, rainwater j, et al. 2012. screening mammography beliefs and recommendations: a web-based survey of primary care physicians. bmc health serv res. 12, 32. pubmed http://dx.doi.org/10.1186/1472-6963-12-32 32. smith ra, cokkinides v, brooks d, saslow d, brawley ow. 2010. cancer screening in the united states, 2010: a review of current american cancer society guidelines and issues in cancer screening. ca cancer j clin. 60(2), 99-119. pubmed http://dx.doi.org/10.3322/caac.20063 33. desantis c, siegel r, bandi p, jemal a. 2011. breast cancer statistics, 2011. ca cancer j clin. 61(6), 40818. pubmed http://dx.doi.org/10.3322/caac.20134 34. hendrick re, helvie ma. 2012. mammography screening: a new estimate of number needed to screen to prevent one breast cancer death. ajr am j roentgenol. 198(3), 723-28. pubmed http://dx.doi.org/10.2214/ajr.11.7146 35. welch hg, black wc. 2010. overdiagnosis in cancer. j natl cancer inst. 102(9), 605-13. pubmed http://dx.doi.org/10.1093/jnci/djq099 36. kalager m, adami ho, bretthauer m, tamimi rm. 2012. overdiagnosis of invasive breast cancer due to mammography screening: results from the norwegian screening pro gram. ann intern med. 156(7), 491-99. pubmed http://dx.doi.org/10.7326/0003-4819-156-7-201204030-00005 37. morrell s, barratt a, irwig l, howard k, biesheuvel c, et al. 2010. estimates of overdiagnosis of invasive breast cancer associated with screening mammography. cancer causes control. 21(2), 275-82. pubmed http://dx.doi.org/10.1007/s10552-009-9459-z http://ojphi.org/ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16757721&dopt=abstract http://dx.doi.org/10.1001/jama.295.21.2492 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21169259&dopt=abstract http://dx.doi.org/10.1158/1078-0432.ccr-10-1533 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17620276&dopt=abstract http://dx.doi.org/10.1002/cncr.22836 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20629078&dopt=abstract http://dx.doi.org/10.1002/cncr.25276 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19047281&dopt=abstract http://dx.doi.org/10.1200/jco.2008.17.9952 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22701537&dopt=abstract http://dx.doi.org/10.1371/journal.pone.0037928 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=12204019&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=12204019&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22309456&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22309456&dopt=abstract http://dx.doi.org/10.1186/1472-6963-12-32 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20228384&dopt=abstract http://dx.doi.org/10.3322/caac.20063 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21969133&dopt=abstract http://dx.doi.org/10.3322/caac.20134 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22358016&dopt=abstract http://dx.doi.org/10.2214/ajr.11.7146 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20413742&dopt=abstract http://dx.doi.org/10.1093/jnci/djq099 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22473436&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22473436&dopt=abstract http://dx.doi.org/10.7326/0003-4819-156-7-201204030-00005 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19894130&dopt=abstract http://dx.doi.org/10.1007/s10552-009-9459-z the geographic distribution of mammography resources in mississippi 20 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e226, 2014 ojphi 38. virnig ba, tuttle tm, shamliyan t, kane rl. 2010. ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes. j natl cancer inst. 102(3), 170-78. pubmed http://dx.doi.org/10.1093/jnci/djp482 39. ernster vl, ballard-barbash r, barlow we, zheng y, weaver dl, et al. 2002. detection of ductal carcinoma in situ in women undergoing screening mammography. j natl cancer inst. 94(20), 1546-54. pubmed http://dx.doi.org/10.1093/jnci/94.20.1546 http://ojphi.org/ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20071685&dopt=abstract http://dx.doi.org/10.1093/jnci/djp482 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=12381707&dopt=abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=12381707&dopt=abstract http://dx.doi.org/10.1093/jnci/94.20.1546 ojphi-06-2.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. (page number not for citation purposes) isds 2013 conference abstracts best practices for implementing electronic disease surveillance systems in resources-constrained settings carmen c. mundaca*1, vivek singh2, kayumba kizito3 and julie pavlin4 1uniformed services university, bethesda, md, usa; 2indian institute of public health, hyderabed, india; 3voxiva sarl, kigali, rwanda; 4armed forces health surveillance center, silver spring, md, usa � �� �� �� � � �� �� �� � objective �������� � � ���� ���� ���� �� ������� ���� �� ��������� ����� � ���� ����� � �� � ������� ������� ���������� ��������� ����� ����� ��� ������������ ������ �� ����������� ���������� ����� ��������� ���� �������������� ��������� ������ ������ � � �������������� � ��� �� � ������ ������������ ����� ����������������������� ��������� � �������� ��� ������� ���� introduction ���� ������ �������� � ����� ���� ����� �� ������� ��� ��������� � �� � �� � ����������������� ����������� ��������������������������������� � �� �������� ��������� ���������� ���������� ����������� ��������� �� � � �������������� ��� ��������������� � ��������������������������������� ��������� ����������������� ����� ����� �� �� !"�� ������������������������� ����������������� ����� ����������� ���� � ������� �������������� ���� ����� ���������������������������� ��������� #����������� �������$����� ����������������������� ������������� � ��� ����� ������������ ������� � �������%������� ��������� ���� � � ��� �������������� ����� ����������������$����� ��������� ���� ����� ���������� �������� ����� ����� ���������� �������� ��������� ����� � ���� ���� ��� ���� ����������� ���� ������� ����� ��������� �������������� ���������� ����� �������������� �������� ������� � &"�� #������������������ �� �� ����� �������� �� ��� �� ���������������� �� ������������������������������� ���������������� �������� �� � � ��� �������'�������� ��� �������������� ����������������������� ������ � ������� ���� ������ �� ��������()�*����� ������� �� ��*����� ����� ���������������� ��� �� ���������������������'� ������������������� ������ ������������ �������� ���� �� ������ ���� �� ��'�������� ���� ���� ������ � +"����� ������ ��������������� ������������ ���� ������� ��� ,-./0����������������� �������$����� � �� ������� ����������������� ���� ��������� ���� ���� �������� ���� ������ �������� ������������ ������ ��� ������������������������������������� ������� ����� � methods ���������� � � � � ���� ������!1���������� ��������������� ��� �� ���� � � � � ��� �������������'�������� �� ������ ����� ����� �������� ��� ���� ��������������������� � �� � ������� ������� ��������� � ������������ ������� �� �� ����� ������������� ���� �� �� ����� ����� ���2���� � ���� ��������� �������� �������������� ����������� ����� ���3����������� �����#���������� �������'������������ ������ � � ����� ������������� ����������������������� ��������� ������� ��� �� ������ ��������������� ���� �� � ����4 ����� �������������� � �� � ���� �������� ���������� ����� ����� ����� �����������������������������-./�����3�����5���� �������������� ������� ����� ����������� �������� ������������������'�������� �� � � ��� ����������$������)� ����)�������-�����&6!&����� ����� � � � ��������������������������������� ��� �������� ���� �� ���� ������� ������'�������� ���������� ��� �������� � ���7�!0������������������� � �������� ��� ��&0��������������� ������������ � ����� ���������� ��� �� ����+0� ����� ����� ���� ��� � results ������� ��!1������� ������ �� ���� � ����� ������������� ���� � ���������������������������� ��� ������ � � ����������� ����� 8���� �� �����������'�������� ���������������� � �� ��������������������� ��������������� ��������� ������������ ���'�������� ���������������� ������� � ���� � ����� ������ �� ������������ ���� ������������� ���������� � ����������������� � �� ������� ����� ������ � � ����������� ���� �������� ��������� ������������ ���� ���������������� � �� �� ����������� ����������������������� ��� �������������'�������������� ����������� � � �� �� ��������� ������������ ��������� � �������� � ���� ���� ������� ���������� ���������������������� keywords � ������������ 9���� ���������������� 9����� �������������� references !�� )�����������:�;���3��3����������:�)��<�� � ������������ �#������� ����� �/�� ���4��� ����� 7���� ��������� ������ ��� ���� ������ ��� ��� ��� �������� � ����-������ ���/�� ���������&66=��!,&07����!!=�&!� &�� *� ���������5����������� �� ����������������� �� 7���������������� ���� � ��� ���� ������ ��� ����� ������/�� ����� ����� ����&66=��&&,!07���� !+�&6� +�� *�*��(�������>���� ��� �����?�� ���������� ���/�� ���)����� ����� )� �����&66!��*����� ������� �� ��*����� ���������������� *carmen c. mundaca e-mail: mundaca.cecilia@gmail.com� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e2, 2014 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluation of essence in the cloud using meaningful use syndromic surveillance data wayne loschen*1, william stephens2, taha kass-hout3, miles stewart1, dave heinbaugh2 and joseph lombardo1 1johns hopkins university applied physics laboratory, laurel, md, usa; 2tarrant county public health, fort worth, tx, usa; 3public health surveillance and informatics program office, office of surveillance, epidemiology, & laboratory services, centers for disease control and prevention, atlanta, ga, usa objective this project represents collaboration among cdc’s biosense program, tarrant county public health and the essence team at the johns hopkins university apl. for over six months the tarrant county public health department has been sending data through the biosense 2.0 application to a pilot version of essence on the amazon govcloud. this project has demonstrated the ability for local hospitals to send meaningful use syndromic surveillance data to the internet cloud and provide public health officials tools to analyze the data both using biosense 2.0 and essence. the presentation will describe the tools and techniques used to accomplish this, an evaluation of how the system has performed, and lessons learned for future health departments attempting similar projects. introduction in november of 2011 biosense 2.0 went live to provide tools for public health departments to process, store, and analyze meaningful use syndromic surveillance data. in february of 2012 essence was adapted to support meaningful use syndromic surveillance data and was installed on the amazon govcloud. tarrant county public health department agreed to pilot the essence system and evaluate its performance compared to a local version essence they currently used. the project determined the technical feasibility of utilizing the internet cloud to perform detailed public health analysis, necessary changes needed to support meaningful use syndromic surveillance data, and any public health benefits that could be gained from the technology or data. methods this project investigated database and visualization changes necessary to support meaningful use syndromic surveillance data in essence. it evaluated the internet cloud environment and determined the benefits and disadvantages to using this technology as a platform for essence. this included scalability, performance, and cost analysis of the internet cloud platform. after using the system for a period of time, the tarrant county users evaluated the internet cloud version of the system. results many technical adaptations to the essence system were made to support the new meaningful use syndromic surveillance elements. several optimizations, including a new database schema and cube table structures, were developed to improve performance of essence in the internet cloud and incorporating the meaningful use requirements. the internet cloud platform offered many levels of performance that could alter the essence user experience. smaller configurations allowed for 100 concurrent users to experience 16 second response times, whereas larger configurations supported experiences of 2 second response times. conclusions public health departments are dealing with new meaningful use syndromic surveillance data elements and the cost of maintaining local systems. this collaborative team have researched and evaluated tools, technologies, and solutions that can be used throughout the country. keywords electronic medical records for public health; interoperability; meaningful use; syndromic surveillance; internet cloud acknowledgments the essence in the cloud initiative is supported by the cdc’s division of notifiable diseases and healthcare information (dndhi) biosense program. *wayne loschen e-mail: wayne.loschen@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e54, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts can we use syndromic surveillance data to identify primary care visits to nyc eds? jessica athens* new york city department of health and mental hygiene, new york city, ny, usa objective to develop a syndrome classification based on patient chief complaint to (1) estimate the proportion of primary care-related emergency department (ed) visits in new york city (nyc) hospitals and (2) explore predictors of such visits. introduction nyc eds saw nearly 4 million visits in 2011. studies have demonstrated that non-urgent visits can account for more than 50% of visits to eds [1,2]. designed to provide rapid diagnosis and first-line treatment of serious illness, eds often function as a primary care site due to their accessibility. unfortunately, use of eds for primary care may affect their ability to meet the needs of severely ill patients. methods we examined syndromic surveillance data from 45 hospitals in nyc for 2011 and classified visits into a primary care syndrome based on the chief complaint field. data from 4 hospitals were omitted due to data quality issues, as were records from non-nyc residents. primary care (pc) syndrome visits included visits recorded as referrals, screenings, suture removal/dressing changes, or medication refills; records with a blank or non-informative (e.g. “x”) chief complaint field were omitted from analysis. using unique patient ids, we identified patients who visited the same ed multiple times in the previous 12 months. a hierarchical generalized linear mixed effects model with hospital-level random effects was used to explore patient characteristics associated with pc syndrome visits. the model included a random intercept for hospital and the following covariates: duplicate visit, patient gender and age group (ages 0-4, 5-17, 18-64, and 65+), and time of visit (midnight to 8 am, 8 am to midnight). covariates for month and day of week were included to control for temporal trends in ed visits. model parameters were estimated by maximum likelihood. estimation was performed in sas version 9.2 [3] using the glimmix procedure. results citywide, 7.5% (n=190,431) of visits to eds during 2011 were classified as pc syndrome visits, but varied by hospital with a median of 4.6% (iqr: 3% to 9%) across hospitals.the average proportion of pc syndrome visits varied by hospital. of the 45 hospitals included in the analysis, 18 had a lower baseline, 13 were the same, and 14 had a higher baseline than the city mean. hospitals with a larger census had a larger proportion of pc syndrome visits. age had a significant effect on the odds of a pc syndrome visit; ages 0–4 had the greatest odds of a pc syndrome visit relative to the 65+ age group. visits from patients ages 5–17 and 18–64 were also more likely to be primary care visits. patients with repeat visits were more likely to have pc syndrome visits. female gender and early morning visits (12a–8a) were associated with lower odds of a pc syndrome visit. conclusions with limited detail on patient visits, our syndrome likely undercounts primary care visits to eds. however, the relationships between our explanatory variables—age, time of day, and duplicate visits— and pc syndrome visits are consistent with the literature on ed usage for primary care. gender is an exception [1], but earlier findings may be confounded by the fact that females seek health care more frequently in general. the variation in pc syndrome visits among nyc eds is significant and may be explained by hospital or community measures not captured in our model, such as clinic wait times, ed capacity, or insurance coverage. in fact, disparities in such predictors of pc syndrome visits could be targets for interventions. our ability to replicate previous findings on the use of eds for primary care visits suggests that syndromic data may be a near real-time data source for following trends in such visits. predictors of pc syndrome visits all covariates significant at p < .001. keywords misuse of emergency medical services; primary care; variation in emergency department use references 1. carret m, gastal fass a, rodrigues domingues a. inappropriate use of emergency services: a systematic review of prevalence and associated factors. cad. saúde pública. 2009;25(1): 7–28. 2. tang n, stein j, hsia ry, masselli jh, gonzales r. trends and characteristics of us emergency department visits, 1997–2007. jama. 2010;304(6):664–70. 3. sas institute, inc., cary, nc. *jessica athens e-mail: jathens@health.nyc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e56, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts estimation of influenza incidence by age in the 2011/12 seasons in japan using sassy yasushi ohkusa*1, yoshinori yasui1, tamie sugawara1, nobuhiko okabe2, 1, kiyosu taniguchi1 and kazunori oishi1 1idsc,niid, shinjuku, japan; 2kawasaki city institute for public health, kawasaki, japan objective so far, it is difficult to show the incidence rate of influenza in the official sentinel surveillance in japan. hence we construct the system which record infectious diseases at schools, kindergartens, and nursery schools, and then can show the accurate incidence rate of influenza in children by age/grade. introduction so as to develop more effective countermeasures against influenza, timely and precise information about influenza activity at schools, kindergartens, and nursery schools may be helpful. at the infectious diseases surveillance center of the national institute of infectious diseases, a school absenteeism surveillance system (sassy) has been in operation since 2009. sassy monitors the activity of varicella, mumps, mycoplasma pneumonia, pharyngoconjunctival fever, hand-foot-mouth disease, influenza, and many other infectious diseases in schools. in 2010, sassy was extended to the nursery school absenteeism surveillance system (nsassy). these systems record the number of absentees due to infectious diseases in each class of all grades of schools every day. as a powerful countermeasure to the pandemic flu of 2009, sassy was activated in 9 prefectures, in which included more than 6000 schools, and it is gradually being adopted in other prefectures. as of february 2012, 18 prefectures and 4 big cities, which together comprised 15,700 schools (about 35% of all schools in japan), utilized sassy. nsassy is used in more than 4100 nursery schools, which is about 18% of all nursery schools in japan. some studies of similar systems were performed in the uk (1), hong kong (2), and the usa (3,4), examined surveillance systems for monitoring infectious disease incidence, but the systems to construct in those studies do not operate nationwide like sassy or nsassy, and they cannot provide influenza incidence rates in children. methods all schools, kindergartens, and nursery schools in the community, enter data of the absentees due to infectious diseases into the system every day, thereby providing real-time data regarding infectious diseases prevalent in schools, to the schools around, school boards, public health centers, local governments, and medical professionals. it analyzed data for the 2011/2012 season (from september 1, 2011 to march 31, 2012) mainly, but also two seasons (2010/2011 and 2011/2012) were compared in some prefectures. in total, 12 prefectures, which comprised 2,352,839 children, were participated in 2011/2012 season. in the 2010/2011 season, 1,795,766 children of 9 prefectures were analyzed. results the incidence rate in the first grade of elementary schools is the highest both in the two seasons. the highest incidence rate in this grade distributes from 17.8% to 40.3% in 2011/2012 season, and from 11.0% to 30.7% in 2010/2011 season. conclusions this study proved sassy and nsassy are quite useful for monitoring of influenza outbreak in schools and it will be gold standard of surveillance for school children in japan. the present study also showed incidence rate of influenza in children at schools, kindergartens, and nursery schools, and proved the highest incidence was in the first grade of the elementary school. this is the first finding using such the huge number of subjects, which is more than 2 million. the intervention targeting to the weak age/grade is necessary for effective countermeasure and control of influenza and other infectious diseases. keywords surveillance; influenza; school absenteeism acknowledgments this paper is financial supported by ministry health, labour and welfare, japan. references 1) schmidt wp, pebody r, mangtani p: school absence data for influenza surveillance: a pilot study in the united kingdom, eurosurveillance, volume 15, issue 3, 21 january 2010 2) calvin k.y. cheng, benjamin j. cowling, eric h.y. lau, lai ming ho, gabriel m. leung, and dennis k.m. ip, electronic school absenteeism monitoring and influenza surveillance, hong kong, emerg infect dis. 2012 may 3) buehler jw, berkelman rl, hartley dm, peters cj: syndromic surveillance and bioterrorism-related epidemics. emerg infect dis. 2003; 9:1197-204. 4) besculides m, heffernan r, mostashari f, weiss d.:evaluation of school absenteeism data for early outbreak detection, new york city. bmc public health. 2005 oct 7;5:105 *yasushi ohkusa e-mail: ohkusa@nih.go.jp online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e142, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 111 (page number not for citation purposes) isds 2012 conference abstracts evaluating the variation on public health’s perceived field need of communicable disease reports uzay kirbiyik*1, 3, roland gamache2, 3, brian e. dixon2, 3 and shaun grannis1, 3 1indiana university, school of medicine, indianapolis, in, usa; 2indiana university, school of informatics, indianapolis, in, usa; 3health informatics, regenstrief institute, inc., indianapolis, in, usa objective to assess communicable disease report fields required by public health practitioners and evaluate the variation in the perceived utility of these fields. introduction communicable disease surveillance is a core public health function. many diseases must be reported to state and federal agencies (1). to manage and adjudicate such cases, public health stakeholders gather various data elements. since cases are identified in various healthcare settings, not all information sought by public health is available (2) resulting in varied field completeness, which affects the measured and perceived data quality. to better understand this variation, we evaluated public health practitioners’ perceived value of these fields to initiate or complete communicable disease reports. methods we chose four diseases: histoplasmosis, acute hepatitis b, hepatitis c and salmonella. we asked public health practitioners from marion county health department (mchd) of indianapolis to list the fields they felt were necessary when submitting a communicable disease report. we then asked them to evaluate those fields using the following criteria: required – a critical case attribute, when missing or unknown, would make the task of initiating and/or closing a case impossible or exceedingly difficult. desired – a case attribute allowing more complete epidemiologic profiles to be developed but, if missing, would not prohibit initiating and/or closing a case. not applicable – a case attribute that is not usually collected to initiate and/or close a case for the particular condition. to quantify the need for the fields, we assigned a number to each response as follows: 0 not applicable 1 desired 2required we summed the numbers for each field for each disease and created a table for the perceived need of that field (table 1). results the perceived needs table showed a difference between the fields needed to initiate or close a case. moreover the perceived need for fields varied by disease as well. to assess the difference in perceived needs, we calculated the standard deviation of the fields (table 2). conclusions data quality is essential, not only for research but to support routine public health practice as well. many factors affect data quality; one of them is perceived need of the information by public health practitioners. despite working with public health stakeholders from the same organization we observed variation in their perceived needs for these fields to initiate or close a communicable case. these results highlight another source of the problem regarding health information quality and its goodness of fit issues. table 1. perceived need for the selected communicable disease reports fields. higher numbers (darker color) reflect greater perceived need. table 2. standard deviation of perceived need values for each field. higher numbers reflect more disagreement among responses. isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 112 (page number not for citation purposes) isds 2012 conference abstracts keywords completeness; data quality; communicable disease reports acknowledgments we thank the mchd of indianapolis for their help with this research. references 1. morbidity and mortality weekly report (mmwr) june 1, 2012 / 59(53);1-111 http://www.cdc.gov/mmwr/preview/mmwrhtml/ mm59 53a1.htm 2. indiana confidential report of communicable diseases state form 43823 (r2/11-96) https://forms.in.gov/download.aspx?id=5082 3. wang r y, strong d m, guarascio l m. beyond accuracy: what data quality means to data consumers. journal of management information systems 1996; 12 (4); 5–33. *uzay kirbiyik e-mail: ukirbiyi@iupui.edu layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts state foodborne illness surveillance and response laws: compilation and analysis stephanie david, jenna burton, chris chadwick and rebecca katz* george washington university, washington, dc, usa objective to document and assess the variation in state legislation relating to foodborne disease surveillance and outbreak response for all 50 states and the district of columbia by creating a database and appendix of laws and regulations that will be made available to researchers and policymakers. introduction foodborne illnesses sicken 48 million and kill 3,000 americans every year, presenting an enduring threat to the public’s health. in just the past three years alone, the united states has experienced at least four major multistate outbreaks in food. despite this growing problem, efforts to prevent foodborne illness pose a particular public health challenge due in part to the widely variable laws governing foodborne illness surveillance and outbreak response. the recent passage of the food safety modernization act (fsma) presents an opportunity for researchers, program managers, and policy makers to assess and correct the legal barriers that may hinder states in effectively implementing the fsma’s vision with regard to increased state and local capacity for surveillance and outbreak response. methods we conducted a systematic review and analysis of laws and regulations relating to foodborne illness surveillance and outbreak response in all 50 states and the district of columbia, using the following methods: (1) we created a database to record state laws and regulations relating to foodborne illness surveillance and outbreak response in all 50 states and the district of columbia; (2) we conducted a basic gap analysis of state foodborne illness surveillance and outbreak response laws and policies collected in the database; and (3) we conducted case study analyses of previous multistate outbreaks from 2008-2011. results through compilation of the state foodborne illness surveillance and outbreak response laws and regulations and analysis of previous multistate outbreaks, we are able to present trends, variations, and gaps in the legislation that directly impacts the ability of public health officials to conduct foodborne outbreak investigations. we also present policy recommendations for strengthening state laws and regulations. keywords surveillance; foodborne disease; outbreak response; public health law; legal preparedness acknowledgments this research was funded by a grant from the rwj foundation. *rebecca katz e-mail: rlkatz@gwu.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e70, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a survey of data recording procedures at new york city emergency departments jessica sell*1 and alyssa wong2 1nyc department of health and mental hygiene, long island city, ny, usa; 2columbia university, mailman school of public health, new york, ny, usa objective to describe the development, implementation, and analysis of a hospital based emergency department (ed) survey and site visit project conducted by the new york city (nyc) department of health and mental hygiene (dohmh). introduction data is collected daily by the dohmh from 49 of the 52 nyc eds, representing approximately 95% of all ed visits in nyc. variability in data fields between and within eds has been noticed for some time. differences in chief complaint (cc) characteristics and inconsistent availability of data elements, such as disposition and diagnosis, suggest that procedures, coding practices and health information systems (his) are not standardized across all nyc eds, and may change within eds. these differences may have an unapparent effect on the dohmh’s ability to consistently categorize ed visits into syndrome groupings, which may alter how syndromic trends are analyzed. prior to this project, the dohmh had no method in place to regularly capture, evaluate or utilize this level of ed-specific information. methods a member of the dohmh contacted all 49 eds to request a brief interview with the ed director, administrator and/or appropriate staff. a questionnaire was designed to collect the following information about each ed: the clinical and administrative his used to collect patient information and report it to the dohmh (including any recent system changes); cc coding practices (i.e. who records the cc, and into which his, and in what format); disposition and diagnosis recording practices and availability. questions regarding hospital specific trends and characteristics were also included. interviews were conducted in person by two members of the dohmh. information from the survey was compiled into a microsoft excel spreadsheet by the interviewers. a descriptive analysis was performed comparing and detailing his used, cc coding practices, and recording procedures for disposition and diagnosis. a member of the dohmh followed up with ed staff and it personnel to resolve any outstanding data quality issues. results all 49 eds were contacted and interviewed. a median of 43 days (ranging from 7 to 167) elapsed between the initial attempt to contact the ed director, and the completion of the interview. all interviews lasted approximately 40 minutes. according to the results of the survey, the dohmh receives information from the clinical his from approximately 20% of eds, from the administrative his from approximately 70% of the eds, and approximately 10% of the eds did not know which system was used to generate the daily reports sent to the dohmh. nearly 100% of the eds reported that the chief complaint was entered into the clinical his by a triage nurse. however, it is not known who records the cc into the administrative system. four eds reported that a dropdown menu is used to record cc into the clinical his, 23 eds cc is in free-text format, and 22 eds cc is a combination of free-text and drop-down format. diagnosis was recorded by the physician at 45% of the eds, and by other staff, including nurses and clerks, at 55% of the eds. two thirds of the eds reported a lag time of less than one week between the visit and assignment of diagnosis codes. disposition is recorded by the physician at 80% of eds. discharge disposition is often required for a patients chart to be considered complete. as a result of the visits the dohmh was able to better understand problems that cause routine data quality problems (e.g. missing data or unusable data) by hospital and identify methods to improve those problems. missing and up to date disposition codebooks were obtained from hospitals. current hospital contacts were identified for follow up. discussions with hospital personnel regarding specific trends, characteristics and interests helped to strengthen the relationship the dohmh has with the hospital ed staff. conclusions differences in practices, procedures, and his used can lead to variability in data quality and characteristics which may affect the ability to categorize visits into effective syndrome groupings and understand trends. further research is needed to develop an improved method for analyzing ed data that takes ed-specific characteristics into consideration. additionally, it is important to establish good working relationships with key members of each ed’s staff in the event of a possible outbreak, and in keeping up to date on any changes within each ed that may affect data quality. keywords emergency department; syndromic surveillance; coding practices acknowledgments nyc dohmh alfred p. sloan foundation *jessica sell e-mail: jsell@health.nyc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e114, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts ili and sari surveillance along the california & arizona borders with mexico, 2011-12 pete kammerer*, gary brice, anthony hawksworth and chris myers operational infectious diseases, nhrc, san diego, ca, usa objective to identify the pathogens responsible for influenza-like illness (ili) and severe acute respiratory illness (sari) along the u.s.-mexico border region in san diego and imperial counties, ca and pima county, az. introduction national borders do not prevent the transmission of pathogens and associated vectors among border populations. the naval health research center (nhrc) has collaborated with the mexican secretariat of health, the u. s. department of state’s biosecurity engagement program (bep) and the u. s. centers for disease control and prevention (cdc) in concert with local health officials to conduct ili surveillance (since 2004) and sari surveillance (since 2009) in the border region. methods respiratory swabs were collected from patients with ili (fever ! 100f, and sore throat or cough) or sari (! 5 y.o.: ili with hospital admission; < 5 y.o.: clinical suspicion of pneumonia with hospital admission) and stored at -70c. specimens were tested with molecular techniques, viral and bacterial culture. results nhrc received and tested 295 ili specimens collected from four surveillance sites in 2011-12. demographics: 53% female, 47% male; 36% 0-4 yrs old, 50% 5-24 yrs old, 8% 25-49 yrs old, 4% 50-64 yrs old, 2% >64 yrs old. pathogens identified included influenza a (15%); rhinovirus (8%); respiratory syncytial virus (rsv) (7%); adenovirus (6%); influenza b (4%) and parainfluenza virus (piv) 1; (4%). 335 sari specimens were collected from 6 sites. demographics: 52% female, 48% male; 41% 0-4 yrs old; 9% 5-24 yrs old, 12% 25-49 yrs old, 11% 50-64 yrs old, 28% >64 yrs old. pathogens identified included rsv (17%); rhinovirus (10%); influenza a (9%); adenovirus (6%); influenza b (2%) and piv 1 (1%). conclusions in 2011-12, our surveillance identified a difference in the proportion of respiratory pathogens affecting outpatients and inpatients. influenza a was isolated more frequently in outpatients, whereas rsv was more frequent in hospitalized patients. we also noted an increased proportion of specimens from the 50-64 yr old and the >64 yr old age groups in the sari surveillance, whereas 86% of the ili specimens are from patients 24 yrs old or less. additional benefits of this collaborative surveillance have been the cooperation, joint training and communication between the participating entities. these preestablished lines of communication are invaluable during a public health emergency, which was demonstrated during the recent influenza pandemic. keywords influenza; ili; respiratory syncytial virus; us-mexico border; sari *pete kammerer e-mail: peter.kammerer@med.navy.mil online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e134, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts an isds-based initiative for conventions for biosurveillance data analysis methods michael coletta4, howard burkom*1, jeffrey johnson2 and wendy chapman3 1johns hopkins applied physics laboratory, laurel, md, usa; 2san diego county health and human services agency, san diego, ca, usa; 3university of california san diego, san diego, ca, usa; 4national association of county and city health officials, washington, dc, usa objective the panel will present the problem of standardizing analytic methods for public health disease surveillance, enumerate goals and constraints of various stakeholders, and present a straw-man framework for a conventions group. introduction twelve years into the 21st century, after publication of hundreds of articles and establishment of numerous biosurveillance systems worldwide, there is no agreement among the disease surveillance community on most effective technical methods for public health data monitoring. potential utility of such methods includes timely anomaly detection, threat corroboration and characterization, follow-up analysis such as case linkage and contact tracing, and alternative uses such as providing supplementary information to clinicians and policy makers. several factors have impeded establishment of analytical conventions. as immediate owners of the surveillance problem, public health practitioners are overwhelmed and understaffed. goals and resources differ widely among monitoring institutions, and they do not speak with a single voice. limited funding opportunities have not been sufficient for cross-disciplinary collaboration driven by these practitioners. most academics with the expertise and luxury of method development cannot access surveillance data. lack of data access is a formidable obstacle to developers and has caused talented statisticians, data miners, and other analysts to abandon the field. the result is that older research is neglected and repeated, literature is flooded with papers of varying utility, and the decision-maker seeking realistic solutions without detailed technical knowledge faces a difficult task. regarding conventions, the disease surveillance community can learn from older, more established disciplines, but it also poses some unique challenges. the general problem is that disease surveillance lies on the fringe of disparate fields (biostatistics, statistical process control, data mining, and others), and poses problems that do not adequately fit conventional approaches in these disciplines. in its eighth year, the international society of disease surveillance is well positioned to address the standardization problem because its membership represents the involved stakeholders including progressive programs worldwide as well as resource-limited settings, and also because best practices in disease surveillance is fundamental to its mission. the proposed panel is intended to discuss how an effective, sustainable technical conventions group might be maintained and how it could support stakeholder institutions. methods members of a technical conventions group would have experience and dedication to advancing the science of disease surveillance. primary functions would include: 1. specify and communicate technical problems facing professionals involved in routine monitoring of population health. alternative use applications would also be considered, such as the use of epidemiological findings to inform clinical diagnoses. 2. independently evaluate the utility of proposed analytical solutions to well-defined problems in public health surveillance and confer approval or certification, perhaps on several levels, such as whether results can be replicated with shareable data. approved solutions might be restricted to commonly available software such as the r language or microsoft excel. 3. facilitate sharing of tools and methodologies to evaluate methods and to visualize their results the framework to be discussed in the proposed panel would be a means of keeping open lines of collaboration and idea-sharing. overcoming obstacles toward this goal is worthy of a conference panel discussion whether or not it concludes that a conventions group is a viable approach. results three 15-minute panelist talks are proposed: 1. background: in-depth description of the dimensions of the problem above 2. constraints facing public health practitioners and requirements for practical analytic tools 3. strawman conventions group: role, logistics, inclusiveness, methods of communicating with stakeholders and related organizations and producing/disseminating output. for the 45 minutes of discussion, the first 15-20 will invite reactions to the first two talks to sharpen the scope of the effort. the remainder of the session will cover the advisability, feasibility, and logistics of an isds-based conventions group, and modify the strawman group concept. keywords standards; data analysis; statistical algorithms; certification *howard burkom e-mail: howard.burkom@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e99, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts poison center data for public health surveillance: poison center and public health perspectives royal k. law*1, josh schier1, jay schauben2, katherine wheeler3 and prakash mulay4 1centers for disease control and prevention, chamblee, ga, usa; 2florida poison information center jacksonville, jacksonville, fl, usa; 3new york city department of health and mental hygiene, new york city, ny, usa; 4florida department of health, tallahassee, fl, usa objective to describe the use of poison center data for public health surveillance from the poison center, local, state, and federal public health perspectives and to generate meaningful discussion on how to address the challenges to collaboration. introduction since 2008, poisoning has become the leading cause of injury-related death in the united states (us); since 1980, the poisoning-related fatality rate in the us has almost tripled.1 many poison-related injuries and deaths are reported to regional poison centers (pcs) which receive about 2.4 million reports of human chemical and poison exposures annually.2 federal, state, and local public health (ph) agencies often collaborate with poison centers and use pc data for public health surveillance of poisoning-related health issues. many state and local ph agencies have partnerships with regional pcs for direct access to local pc data which help them perform this function. at the national level, cdc conducts public health surveillance for exposures and illnesses of public health significance using the national poison data system (npds), the national pc reporting database. though most pc and ph officials agree that pc data play an important role in ph practice and surveillance, collaboration between ph agencies and pcs has been hindered by numerous challenges. to address these challenges and bolster collaboration, the poison center and public health collaborations community of practice (cop) was created in 2010 by cdc as a means to share experiences, identify best practices, and facilitate relationships among federal, state and local public health agencies and pcs. to date, the poison center and public health collaborations cop includes over 200 members from state and local public health, regional pcs, cdc, the american association of poison control centers (aapcc), and the environmental protection agency (epa). a leadership team was created with representatives of the many stakeholders of the community to drive its direction and oversee activities. methods the panel will consist of 4 presenters and 1 moderator, who are members of the poison center and public health collaborations cop leadership team. each presenter will bring a unique perspective of the use of pc data for ph practice and surveillance: cdc, state department of health, a local department of health, and a pc. royal law from the cdc national center for environmental health will present on using pc data for identification of exposures and illnesses of public health significance identified from npds data collected from all 57 pcs. dr. jay schauben from the florida/usvi poison information center jacksonville will discuss pc participation in surveillance and use of pc data for tracking and mitigation of ph events in florida. dr. prakash mulay from the florida department of health will discuss utilization of pc data to enhance essence-based chemical-associated exposure and illness surveillance in florida. katherine wheeler from the new york city (nyc) department of health and mental hygiene will discuss nyc’s use of pc data in surveillance of potential emerging issues, from energy drinks to synthetic marijuana. each presenter will discuss the use of pc data for ph practice and surveillance in his or her organization and jurisdiction, the successes of using pc data, and their challenges. results the moderator will engage the audience by facilitating discussion of the successes and challenges to using pc data for ph practice and surveillance with the audience. sample questions: what are your current capacities and collaborative activities between your state/local health department and your poison center? what non-funding related barriers hinder the collaboration between your state/local health department and poison center? if more funding were available, how would you use this funding to increase the level of interactivity with the poison center and state/local health department? keywords surveillance; poison center; community of practice references 1. warner m, chen lh, makuc dm, anderson rn, and minino am. drug poisoning deaths in the united states, 1980–2008. national center for health statistics data brief, december 2011. accessed 8/29/2012. 2. bronstein ac, spyker da, cantilena lr, green jl, rumak bh, dart rc. 2010 annual report of the american association of poison control centers’ national poison data system (npds): 28th annual report. clin toxicol 2011; 49: 910-941. *royal k. law e-mail: hua1@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e101, 2013 ojphi-06-e121.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 149 (page number not for citation purposes) isds 2013 conference abstracts an evaluation of the key indicator based surveillance system for international health regulations (ihr) -2005 core capacity requirements in india 1public health foundation of india (phfi), indian institute of public health hyderabad, hyderabad, india; 2directorate of health, department of health, medical & family welfare, government of andhra pradesh, hyderabad, india; 3public health foundation of india, new delhi, india; 4institute for health metrics and evaluation, university of washington, seattle, wa, usa; 5london school of hygiene and tropical medicine, london, united kingdom � �� �� �� � � �� �� �� � objective ������� �� ���� � ������� ����� � ���������������� ����� ������� ���� ��� ��������� ����� ����� � ������������� ����� ������� ��� � ������� ���� �������� � � ���� ����������� �� �� �� ������ ����� ��� ���� �������������� ������ �!����������� �"���������# introduction ���� ����� � � ���� $��� ���������� �� ��� ����� ����� � ���� ��� ���� �������� ��� � � � ���� ����� ����� ����� ���� �� ��� �� ������� � ��� %��������������������&'()**+#���������������� �� ����������������� ������������� ��������������� ��������� �������������������� ������ �� ������� � � �� �� �� ������ � ��� ���� �������#� , ��� � ���� ��%������ ��� � �������� �������� ���������%���� ������� ����� ����� �� ������� ������� ��������� ������ ������������������� ��� ������ ������� ���� ���� ������ ��� ���� �&'�)**+� ��%�������� � ��� ������� � ���� � ��� � ��� ��� �������# methods !���� � ������� � �������� ��������$������� ������ �)-��� ����� � ��� ���� ����#� !� ����� ���� ����� �������� ���� ���� ���� $��� ������ � ����� .�� ���� ��������� � ��.� �� �� ���� ��� � ���� /��� ����� � � � �������$ �� ����� ����������� "��� �� ������ � ����0��� ����� � ����� � �������� ������������ �����1��� ����1 ������-+���� ��� ��� ���� � ��� �����������22*�3����� ���������������� ��3�� �"���������� �������� � ���� ����������������� � � �� � ����� ����������� #����� �������$� �������� � ������� ��������� �������� �������$ ������ ���������� 4�� ��&�� ���5�����6�������4&5���������������7�8�������� #� ��� ��� �������� � ����� ����� � ��� # results 5���� "� ����� ���� �� �� ��������� ���� ������� � � ��%������ ��� ����������������� ������� ����� �������������������� ������� ��� �� �� ���� ������������ �������� ������������� ����������������������� ��� ��� �����"������������������ �&�� ��"������������� ������������ ���� �������� ���#�������� ������%�������������������� � ��� ����� � ���� ��������� ������������� ����� ��$�� ������������������ �������������� ����� ����� ����� ����� ��� #��������� �������� ��������� ������� ������ ��#����� �������������������� ����$����� ����� ��� �� ����� � ���� �5� ��2��29:������� �0��� ������ ����������� ��� �������������� � � ���� ������������ � �#�,������� ����� ��������� � � ��+:�3�� ���������� ����$����� ��������������� ��� ����������������� ����$#����������� ���������� ������������� �� ����������� ���� ���� ��*:��� ����� ������ � ������� ������������� ���������� ������ ������������� ��;9:�3�� ����� �<�������������� ������ ������ ���# conclusions ��� ����� ���� �&'�)**+� ����� ��������� ��%�������� � ��� )*2+� ���� ����� �� � ����"� 2#� =������� ������������� �������� � � ���������� � ������� ���� ����������� ��� ��� ������ ���� ������ ��� ���� ������� � � ��������������� ��� �����#�)#���������������� � ���������������������� � � ��� ���������������� �������� �������������� ��� ������������$ �-#� '��� ����������� ������������������ ��������������������� ���������� ������ ���"�����;#�!��%�������� �6������� ��� ��������"��������� ����������������� ����������������������� ����� ��������� � � ����� ���������� ������ ���������� ��������������� � ���# keywords �&'�)**+������� �����/����/��������'�%��������>�3������������� ?� ��������� ������� ���������>�,�� �������@������ acknowledgments !����� ���$��� ������������������������ ��������������� ��� ����������� � �������������������� ���� ��"������� ����� ��� ���� ���"�=���������� � �!����������� �#���� ����$��� ������� ��� � �� ���������������������� 4� �������� ��/��������������������������������!�������������&@������ ��� �������� �13�1����� ���� # references 2#���������������������� �� �������� �������� ��������� ������ ��������� ��������#�����4�� ��?��$"�)**2�/��������8�#a����2*+2)# )#� ���� �� 3#� ����������� �� �� � � ������ ����� ��� ���� ������� �������� �� ��� � ����b � �� #� ������� ����� � � � ��� ��� ��� ��#� )**c� d� � ���>+)�-�a2-0�;-#����7����7��a�2e2cec-+# -#�d�����d"���������f"��������g�"�3�$$���7#�/������������� ������ � �� ������ ��� �� � ���������#�f�����#�)*22�d���2+>-99�e902�a)+)�0e#� ���7����7��a�)2))9+**# ;#�!���� �d3"�!��� ����h"�5 ����5"�! ����������#�= ��� ���� ��� �������� �������������������� �&�� ���'��� ����� #�?7/���� ������ ��#�)*2*>2*� ���� � 2a�)#� ���7��� �7��a� )22;-c);#� ������� /����� � �7/��a� �7/-**++9;#�,����)*2*i2)i))#����# +#�4�� ��&�� ���5�����6�����a�/��������� ���� �� �� ����� ��������� �� ��� �� � ��������������������������������� �������4�� ��&�� ��� 5�����6�����"�)**0# 0#�7�8�����d"�/���������"�'����7"�4������"�8 �������"�! ����4"���� � #�/�������� � �������$�� ���� ������ ��� ����� �������������������� �� ���� �������������� ��� �������� ���#�?7/���� ������ ��#�)**)>)a)#� ���7����7��a�22c;0cce#��������/����� ��7/��a�0++ec# *vivek singh e-mail: vivek.singh@iiphh.org� � � � vivek singh*1, jagan mohan2, u prasada rao2, lalit dandona3, 4 and david heymann5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e121, 2014 sustainable surveillance paper 10.01.2012nm.docx.docx steps to a sustainable public health surveillance enterprise 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi steps to a sustainable public health surveillance enterprise a commentary from the international society for disease surveillance nabila mirza, 1 tera reynolds, 1 michael coletta, 2 katie suda, 3 ireneous soyiri, 4 ariana markle, 5 henry leopold, 6 leslie lenert, 7 erika samoff, 8 alan siniscalchi, 9 laura streichert 1 1 international society for disease surveillance; 2 national association of county and city health officials; 3 university of tennessee; 4 monash university; 5 university of california, los angeles; 6 healthwizer; 7 university of utah health care; 8 university of north carolina – chapel hill; 9 connecticut department of public health introduction at a time when populations are changing and disease outbreaks and other events of public health significance pose increasing risks to global health, economic stability, and national security, it is essential that, as a nation, we invest in the systems needed to promote and protect the public’s health. abstract more than a decade into the 21 st century, the ability to effectively monitor community health status, as well as forecast, detect, and respond to disease outbreaks and other events of public health significance, remains a major challenge. as an issue that affects population health, economic stability, and global security, the public health surveillance enterprise warrants the attention of decision makers at all levels. public health practitioners responsible for surveillance functions are best positioned to identify the key elements needed for creating and maintaining effective and sustainable surveillance systems. this paper presents the recommendations of the sustainable surveillance workgroup convened by the international society for disease surveillance (isds) to identify strategies for building, strengthening, and maintaining surveillance systems that are equipped to provide data continuity and to handle both established and new data sources and public health surveillance practices. keywords: disease surveillance, enterprise, sustainable, policy, information technology, epidemiology correspondence: lstreichert@syndromic.org copyright ©2013 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. mailto:lstreichert@syndromic.org steps to a sustainable public health surveillance enterprise 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi in 2002, the institute of medicine (iom) reported that the public health system in the united states had a multitude of deficiencies that impact the ability to effectively conduct public health surveillance. these included outdated and vulnerable technologies; a public health workforce lacking training and reinforcements; lack of real-time surveillance and epidemiological systems; and ineffective and fragmented communications networks. 1 while considerable headway has been made since the iom report was published, there is still evidence of a need for further improvements. a recent report by trust for america’s health, for example, found that there are persistent gaps in the ability of state and local public health agencies to respond to events ranging from bioterrorist threats to natural disasters and disease outbreaks. 2 the question is—how can we reduce these gaps? nationwide and globally, rapid changes in health information systems, cloud computing technologies, communications, and global connections are catalyzing a re-examination of disease surveillance as an enterprise that needs coordinated and integrated system elements. sustainable surveillance, which we define as ongoing data collection, analysis, and application, coupled with a capability to respond to novel demands, is needed to ensure that public health agencies can perform reliably regardless of shifts in public health funding and priorities. the isds sustainable surveillance workgroup identified the following steps to maintain and advance the public health surveillance enterprise: 1. recognize systematic and ongoing public health surveillance as a core public health function that is essential for population health, economic stability, and national security. 2. create and support funding mechanisms that reinforce enterprise (i.e., integrated systems), rather than categorical (i.e., disease or program specific) surveillance infrastructures and activities in order to reduce inefficient silos, leverage resources, and foster synergies. 3. oppose further cuts to spending for surveillance activities. 4. invest in surveillance workforce development to build competencies and improve organizational capacity to utilize technological advances in surveillance practice. 5. advance a rigorous surveillance research and evaluation agenda that will deepen the understanding of community health, identify best practices, and provide evidence for decision-making. steps to a sustainable public health surveillance enterprise 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 1: recommended steps to a sustainable surveillance enterprise background public health surveillance is defined as, “the systematic and ongoing collection, management, analysis, interpretation, and dissemination of information for the purpose of informing the actions of public health decision makers.” 3 in addition to providing information about the health status of our communities, surveillance is a foundation of emergency preparedness, food safety, infectious disease outbreak prevention and control, chronic disease assessments, and other key areas that protect the health, economy, and security of the public. while public health surveillance policy and practice have been indicated as priorities for policymakers at the national steps to a sustainable public health surveillance enterprise 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi and global levels, 4–7 questions remain about how to move forward from planning to implementation, especially in a time of critical cuts to federal funding. progress in health information technology (it) and the increased use of electronic data and new data streams offer great potential for innovation in surveillance science and practice. for instance, the self-reporting of health information through social media (e.g., twitter), as well as crowdsourcing projects such as flu near you (www.flunearyou.org) offer new options for collecting timely data. in addition, the health information technology for economic and clinical health (hitech) act, 8 legislated as part of the american recovery and reinvestment act (arra) of 2009, is fueling the adoption of electronic health record (ehr) systems in the u.s. 9 in return for financial subsidies to implement ehr systems, hospitals and doctors are required to share data for public health purposes 9 with the intent to improve both population health outcomes and the quality of clinical practice. sustainable surveillance systems have the potential to advance both of these goals. 10 the value of public health surveillance 1. recognize systematic and ongoing public health surveillance as a core public health function that is essential for population health, economic stability, and national security. public health surveillance data is the foundation of public health programs and is required for a number of purposes, including: to demonstrate the size and impact of the public health problem being addressed by a program; to identify the population groups to which additional prevention efforts should be directed; to determine whether the problem is growing in size or abating; to provide feedback to data providers; and as part of an overall program evaluation strategy. the significant health impacts and economic costs of disease outbreaks illustrate the critical importance of effective public health surveillance and rapid response, as well as the cost of inaction. 11 table 1 provides examples of the health and financial burdens posed by some naturally occurring and intentional infectious disease outbreaks. http://www.flunearyou.org/ steps to a sustainable public health surveillance enterprise 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi table 1: examples of health impacts and economic costs associated with disease outbreaks and epidemics disease transmission health impact financial cost severe acute respiratory syndrome (sars), global, 2002 and 2003 droplet (direct) 8,096 infected, including almost 800 deaths 12 $40-$54 billion 13 anthrax attack, united states, 2001 bioterrorism (indirect) 22 cases, including 5 deaths 14 about $320 million 15 pandemic flu, united states droplet (direct] projected death of millions of people 16 projected cost of $800 billion over a whole year 17 pertussis, washington state, 2012 droplet (direct) over 3000 cases through early july 18 over $2,000 per case 19 west nile virus, sacramento county, 2005 vector (indirect) 163 people infected 20,21 $2.98 million [treatment cost and productivity loss] 21 salmonella, north dakota, 2009 foodborne (indirect) 180 people infected 22 $38,000 in investigation cost [travel, laboratory and staff time) 22 cholera, latin america, 1991 waterborne (indirect) 400,000 cases including over 4000 deaths 23 $770 million loss in food trade embargoes and adverse effects on tourism 23 tuberculosis, global, 2011 droplet (direct) 8.7 million cases, 1.4 million deaths 24 projected economic cost of up to $8 billion per year between 2013 and 2015 for low and middle income countries 24 the values reported in table 1 do not fully reflect additional indirect costs of diseases and their potentially crippling effects on a community, nor do they address costs that are underreported/ unreported due to lack of data. higher rates of illness, for example, can lead to lower worker productivity, 11 while premature mortality can reduce the size of the labor force, both of which have economic ramifications. there is growing evidence that these economic and societal costs can be mitigated by surveillance systems that are stable; a stable system provides the best foundation for identifying whether the problem being addressed is getting bigger or smaller or disproportionately affecting a section of the population, etc., while still allowing flexibility to provide useful information quickly about emerging issues. the optimum mix of stability and flexibility will depend on the purpose(s) of surveillance and the particular health condition under surveillance. for example, in steps to a sustainable public health surveillance enterprise 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi the case of sars, an effective surveillance system has the potential to decrease the size of an epidemic by one-third and the duration by 4 weeks, with significant cost savings. 25 another study found that the early detection of an outbreak of highly infectious bacterial meningitis saved approximately $2 for every dollar invested in infectious disease surveillance. 26 yet another evaluation of surveillance practice found that technological improvements in a sentinel influenza-like illness (ili) surveillance system in virginia saved over $9,500 (1,992 hours) in staff-time during the 2007-2008 influenza seasons. 27 ongoing surveillance can also inform the design and evaluation of prevention and intervention programs in order to control the escalating costs associated with chronic diseases in the u.s. and abroad. 28 some experts forecast that chronic disease prevention programs could save up to $48.9 billion per year by 2030, 29 while others predict applying electronic medical record implementation and networking to the prevention and management of chronic disease will exceed the currently projected $81 billion in annual savings. 30 enterprise models for surveillance practice and funding 2. create and support funding mechanisms that reinforce enterprise (i.e., integrated systems) rather than categorical (i.e., disease or program-specific) surveillance infrastructure and activities in order to reduce inefficient silos, leverage resources, and foster synergies. siloed surveillance systems are outdated, inefficient, and incapable of meeting today’s demands for electronic data exchange and for the informatics capabilities needed to use the information for maximum benefit. integrated programs and collaboration, on the other hand, facilitate the efficient management of the complex, varied, and proliferating issues and information sources that exist today. the nature of public health surveillance also lends itself to multiple-purpose approaches in that strategies for preventing and controlling diseases, such as west nile virus, are to a great extent the same as for an influenza epidemic, a foodborne disease outbreak, or a bioterrorist attack. 31 technology that enhances communication and data sharing across disease programs, surveillance systems, and even across jurisdictions increases the ease of obtaining and disseminating useful information to a broad audience, including public health agencies, healthcare providers, policymakers, and the general public. 6,32 this rapid information exchange not only facilitates timely response, but can also reduce emergency room visits, hospital admissions, and even costs of care. 33 however, many health departments currently have systems that are not flexible enough to respond to changing health it needs, which makes it difficult to deliver information when and where it is needed. 4 disease or program-specific funding also exacerbates program vulnerability to funding and budgetary cuts. for example, when funding is earmarked for specific purposes (e.g., emergency preparedness and associated surveillance systems), and then is reduced, such as has occurred for public health emergency preparedness cooperative agreement funding through cdc in the past seven years, 34 it can undermine and reverse efforts to establish sustainable systems that serve multiple crosscutting purposes throughout public health. steps to a sustainable public health surveillance enterprise 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi by contrast, an enterprise approach provides a cohesive framework that will better equip public health practitioners to address the challenges of processing large volumes of electronic data, and the concomitant analytical and visualization requirements. specifically, enterprise funding supports a reliable, flexible infrastructure that can adapt to technological and information requirement changes, and allows for ongoing data collection and the integration of new data sources to advance all-hazard preparedness. a 2004 white house memo acknowledged how programmatic funding can lead to inefficiencies and redundancies in system acquisitions and usage and called for applying technological and human resources across programs. 35 by encouraging collaboration within and between departments, surveillance professionals can take advantage of shared platforms and resources to optimize data collection, analysis, storage, and dissemination, thus helping to reduce operational costs and improve efficiency. for example, collaboration could create opportunities for the effective integration of syndromic and reportable disease data for public health use. 36 stable funding and sustainable surveillance 3. oppose further cuts to spending for surveillance activities. a lack of consistent and sustainable funding is hampering the necessary expansion and improvement of public health surveillance systems at local, state, and national public health agencies. a 2010 survey of local health departments conducted by the national association of city and county health officials (naccho) found that 72% of local health departments reported insufficient funding as one of their major barriers to modernizing their it systems. 37 health data collection systems that take advantage of recent technological advances have proven to be more cost effective and sustainable in the long-term. 38 stable funding is essential to supporting the adoption of hardware and software systems as they become available, leading to a robust and sustainable public health surveillance infrastructure able to integrate, manage, and communicate the plethora of data necessary to generate actionable results. 39 build the base for success 4. invest in surveillance workforce development to build competencies and improve organizational capacity to utilize technological advances in surveillance practice. the new age of disease surveillance requires a skilled public health workforce able to manage large volumes of increasingly complex electronic information, to understand the data flows, and to extract meaning from them. this calls for sophisticated and integrated competencies in public health informatics, epidemiology, statistics, and other areas, and the ability to present findings, draw conclusions, and make recommendations based on surveillance data. furthermore, in addition to needing people who can effectively operate existing surveillance systems and carry out tasks (such as the onboarding process for collecting newly available ehr data) there is also demand for people who can identify and assess new opportunities for surveillance and design new systems that take advantage of these opportunities. 6 steps to a sustainable public health surveillance enterprise 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi attracting and retaining experts in these fields is especially challenging in light of the comparatively low base salaries allotted to public health workers compared to the salaries of technology-intensive positions in other sectors. 40 to align the surveillance workforce with new demands, the isds sustainable surveillance workgroup suggests the following approaches: ● provide training programs for existing and prospective public health workers to equip themselves with the necessary expertise and skills to work in rapidly evolving it systems. ● promote public health careers at the primary, secondary, undergraduate, and graduate levels across disciplines. ● provide competitive salaries to recruit and retain a workforce skilled in public health surveillance and informatics. toward informed decision-making 5. advance a rigorous research and evaluation agenda that will deepen the understanding of community health, identify best practices, and provide evidence to inform decision-making. research and evaluation play an important role in connecting the processes of information collection, information use for decision-making, and translation of decisions to actions and measurable outcomes. research-based evidence and evaluation results can help to identify the limitations and benefits of different surveillance procedures for better decision-making and more effective resource allocation. investing in research and applying the rigors of science to public health surveillance questions leads to informed decisions on how best to direct efforts and resources. in addition, periodic evaluations of surveillance infrastructures – the systems and people—are needed to assess return on investment and opportunities for quality improvement. conclusion effective and efficient surveillance systems are proven to save money and lives. the ability to detect and respond to known and emerging pathogens is central to protecting and maintaining population health. 41 the breakdown or absence of a stable public health surveillance infrastructure, on the other hand, can undermine efforts to mitigate disease outbreaks and other public health events. 31 public health surveillance systems built on a strong infrastructure of core workforce competencies, information systems, and organizational capacity, 42 and supported by consistent and enterprise-based funding, are essential if we are to understand and respond to the real and growing threats to population health. by providing political commitment and financial support to this issue, decision makers can play an active role in advancing the health of individuals, communities, and nations. steps to a sustainable public health surveillance enterprise 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi acknowledgements isds thanks the following members of the isds sustainable surveillance workgroup and others for their input to discussions and manuscript review: gregory danyluk, karen elliott, rennie ferguson, roland gamache, kate goodin, teresa hamby, richard hopkins, jeffrey johnson, abimbola aman-oloniyo, melinda kurtzo, tonya mckennley, erika samoff, amanda schulte, mika shigematsu, vivek singh, kristen soto, sarah winn, saad zaheer, and becky zwickl. this work was supported by the cdc through a cooperative agreement to the task force for global health. corresponding author laura streichert, phd, mph international society for disease surveillance ph: 617-779-7351 email: lstreichert@syndromic.org references [1] institute of medicine (u.s.). the future of the public’s health in the 21st century. washington, d.c: national academies press; 2002. [2] levi j, serena v, m. segal l, st. laurent r. ready or not? protecting the public’s health from diseases, disasters, and bioterrorism, 2010. trust for america’s health and robert wood johnson foundation; 2010. available at: http://www.rwjf.org/en/researchpublications/find-rwjf-research/2010/12/-ready-or-not--.html. (archived by webcite at http://www.webcitation.org/6ggplzq9v) [3] international epidemiological association. a dictionary of epidemiology. 5th ed. oxford; new york: oxford university press; 2008. [4] national strategy for biosurveillance. the white house; 2012. available at: http://www.whitehouse.gov/sites/default/files/national_strategy_for_biosurveillance_july_2 012.pdf. (archived by webcite at http://www.webcitation.org/6ggvjoiwp) [5] public health surveillance and informatics program office. fy 2013-2016 strategic plan. 2012. available at: http://www.cdc.gov/surveillancepractice/documents/final_phsipo_fy1316_strategic_plan 10 15 12 %283%29.pdf. (archived by webcite at http://www.webcitation.org/6ggvughry) [6] smith pf, hadler jl, stanbury m, rolfs rt, hopkins rs. “blueprint version 2.0”: updating public health surveillance for the 21st century. j public health manag pract. 2013 mayjun; 19(3):231-9. [7] implementation of the international health regulations (2005). sixty-fifth world health assembly: world health organization; 2012. [8] hitech act enforcement interim final rule. u.s. department of health and human services; 2009. available at: http://www.hhs.gov/ocr/privacy/hipaa/administrative/enforcementrule/hitechenforcementifr.h tml. (archived by webcite at http://www.webcitation.org/6ggni3br6) http://www.rwjf.org/en/research-publications/find-rwjf-research/2010/12/-ready-or-not--.html http://www.rwjf.org/en/research-publications/find-rwjf-research/2010/12/-ready-or-not--.html http://www.webcitation.org/6ggplzq9v http://www.whitehouse.gov/sites/default/files/national_strategy_for_biosurveillance_july_2012.pdf http://www.whitehouse.gov/sites/default/files/national_strategy_for_biosurveillance_july_2012.pdf http://www.webcitation.org/6ggvjoiwp http://www.cdc.gov/surveillancepractice/documents/final_phsipo_fy13-16_strategic_plan%2010%2015%2012%20%283%29.pdf http://www.cdc.gov/surveillancepractice/documents/final_phsipo_fy13-16_strategic_plan%2010%2015%2012%20%283%29.pdf http://www.webcitation.org/6ggvughry http://www.hhs.gov/ocr/privacy/hipaa/administrative/enforcementrule/hitechenforcementifr.html http://www.hhs.gov/ocr/privacy/hipaa/administrative/enforcementrule/hitechenforcementifr.html http://www.webcitation.org/6ggni3br6 steps to a sustainable public health surveillance enterprise 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [9] lenert l, sundwall dn. public health surveillance and meaningful use regulations: a crisis of opportunity. am j public health. 2012;102(3):e1–7. [10] fine am, nizet v, mandl kd. improved diagnostic accuracy of group a streptococcal pharyngitis with use of real-time biosurveillance. ann intern med. 2011;155(6):345–352. [11] zhang w, bansback n, anis ah. measuring and valuing productivity loss due to poor health: a critical review. soc sci med. 2011;72(2):185–192. [12] summary of probable sars cases with onset of illness from 1 november 2002 to 31 july 2003. world health organization. available at: http://www.who.int/csr/sars/country/table2003_09_23/en/. (archived by webcite at http://www.webcitation.org/6ggpdfszc) [13] lee jw, mckibbin wj. estimating the global economic costs of sars. in: institute of medicine (us) forum on microbial threats; knobler s, mahmoud a, lemon s, et al., editors. learning from sars: preparing for the next disease outbreak: workshop summary. washington (dc): national academies press (us); 2004. available at: http://www.ncbi.nlm.nih.gov/books/nbk92473/. [14] jernigan db, raghunathan pl, bell bp, brechner r, bresnitz ea, butler jc, et al. investigation of bioterrorism-related anthrax, united states, 2001: epidemiologic findings. emerging infectious diseases. 2002 oct;8(10):1019–28. [15] schmitt k, zacchia na. total decontamination cost of the anthrax letter attacks. biosecurity and bioterrorism: biodefense strategy, practice, and science. 2012;10(1):98– 107. [16] king da. epidemiology: infectious diseases: preparing for the future. science. 2006;313(5792):1392–1393. [17] brahmbhatt m. avian influenza: economic and social impacts. the world bank. 2005. available at: http://web.worldbank.org/wbsite/external/news/0,,contentmdk:20663668~pagepk :34370~pipk:42770~thesitepk:4607,00.html. (archived by webcite at http://www.webcitation.org/6ggpwmgfu) [18] handwerker l. officials warn of pertussis outbreak. abc news. 2013. available at: http://abcnews.go.com/health/pertussis-outbreak-worst-50-years/story?id=16814787. (archived by webcite at http://www.webcitation.org/6ggq6iyko) [19] centers for disease control and prevention. local health department costs associated with response to a school-based pertussis outbreak --omaha, nebraska, september-november 2008. mmwr. 2011;60(1):5–9. [20] 2005 human wnv case linelist. california west nile virus website. 2006. available at: http://www.westnile.ca.gov/website/maps_data/2005_maps_data/2005 human wnv case linelist.pdf. (archived by webcite at http://www.webcitation.org/6ggq02uax) [21] barber lm, schleier jj, peterson rkd. economic cost analysis of west nile virus outbreak, sacramento county, california, usa, 2005. emerging infectious diseases. 2010;16(3):480–486. [22] gehring b. health department releases costs of salmonella probe. bismarck tribune. 2010. available at: http://bismarcktribune.com/news/state-and-regional/health-departmentreleases-costs-of-salmonella-probe/article_b638a620-2e2c-11df-afd9-001cc4c03286.html. (archived by webcite at http://www.webcitation.org/6ggqhxgdd) http://www.who.int/csr/sars/country/table2003_09_23/en/ http://www.webcitation.org/6ggpdfszc http://www.ncbi.nlm.nih.gov/books/nbk92473/ http://web.worldbank.org/wbsite/external/news/0,,contentmdk:20663668~pagepk:34370~pipk:42770~thesitepk:4607,00.html http://web.worldbank.org/wbsite/external/news/0,,contentmdk:20663668~pagepk:34370~pipk:42770~thesitepk:4607,00.html http://www.webcitation.org/6ggpwmgfu http://abcnews.go.com/health/pertussis-outbreak-worst-50-years/story?id=16814787 http://www.webcitation.org/6ggq6iyko http://www.westnile.ca.gov/website/maps_data/2005_maps_data/2005%20human%20wnv%20case%20linelist.pdf http://www.westnile.ca.gov/website/maps_data/2005_maps_data/2005%20human%20wnv%20case%20linelist.pdf http://www.webcitation.org/6ggq02uax http://bismarcktribune.com/news/state-and-regional/health-department-releases-costs-of-salmonella-probe/article_b638a620-2e2c-11df-afd9-001cc4c03286.html http://bismarcktribune.com/news/state-and-regional/health-department-releases-costs-of-salmonella-probe/article_b638a620-2e2c-11df-afd9-001cc4c03286.html http://www.webcitation.org/6ggqhxgdd steps to a sustainable public health surveillance enterprise 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [23] global epidemics and impact of cholera. world health organization. available at: http://www.who.int/topics/cholera/impact/en/index.html. (archived by webcite at http://www.webcitation.org/6ggqpnmre) [24] global tuberculosis report 2012. geneva: world health organization; 2012. [25] wallinga j, teunis p. different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures. am. j. epidemiol. 2004;160(6):509–516. [26] public sector consultants, inc. and michigan association for local public health. analysis of the value of local public health operations spending. public health muskegon county. 2010. available at: http://www.muskegonhealth.net/publications/localhealthrpts/lpho_value.pdf. (archived by webcite at http://www.webcitation.org/6ggqdibks) [27] kurkjian k, woolard d, coletta m. cost-effectiveness of influenza-like illness sentinel surveillance in virginia. virginia department of health; 2008. [28] world bank, disease control priorities project. disease control priorities in developing countries. 2nd ed. new york: washington, dc: oxford university press; world bank; 2006. [29] return on investments in public health: saving lives and money. robert wood johnson foundation; 2012. available at: http://www.rwjf.org/content/rwjf/en/researchpublications/find-rwjf-research/2012/03/return-on-investments-in-public-health.html. (archived by webcite at http://www.webcitation.org/6ggqffy8e) [30] hillestad r, bigelow j, bower a, et al. can electronic medical record systems transform health care? potential health benefits, savings, and costs. health aff (millwood). 2005;24(5):1103–1117. [31] baker el, koplan jp. strengthening the nation’s public health infrastructure: historic challenge, unprecedented opportunity. health affairs. 2002;21(6):15–27. [32] mariner w. mission creep: public health surveillance and medical privacy. rochester, ny: social science research network; 2007. available at: http://papers.ssrn.com/abstract=1033528. (archived by webcite at http://www.webcitation.org/6ggqmhzfh) [33] freudenheim m. fast access to records helps fight epidemics. the new york times. 2012. available at: http://www.nytimes.com/2012/06/19/health/states-using-electronicmedical-records-to-track-epidemics.html. (archived by webcite at http://www.webcitation.org/6ggqxvcox) [34] cdc office of public health preparedness and response. 2012 state-by-state update report on preparedness and response. centers for disease control and prevention available at: http://www.cdc.gov/phpr/pubs-links/2012/index.htm. (archived by webcite at http://www.webcitation.org/6ggr5a6r9) [35] white house office of management and budget. omb circular a-87 revised. the white house; 2004. available at: http://www.whitehouse.gov/omb/circulars_a087_2004. (archived by webcite at http://www.webcitation.org/6ggrbjksm) [36] samoff e, waller a, fleischauer a, et al. integration of syndromic surveillance data into public health practice at state and local levels in north carolina. public health rep. 2012;127(3):310–317. [37] the status of local health department informatics: results from the 2010 naccho informatics needs assessment. national association of city and county health officers; 2010. http://www.who.int/topics/cholera/impact/en/index.html http://www.webcitation.org/6ggqpnmre http://www.muskegonhealth.net/publications/localhealthrpts/lpho_value.pdf http://www.webcitation.org/6ggqdibks http://www.rwjf.org/content/rwjf/en/research-publications/find-rwjf-research/2012/03/return-on-investments-in-public-health.html http://www.rwjf.org/content/rwjf/en/research-publications/find-rwjf-research/2012/03/return-on-investments-in-public-health.html http://www.webcitation.org/6ggqffy8e http://papers.ssrn.com/abstract=1033528 http://www.webcitation.org/6ggqmhzfh http://www.nytimes.com/2012/06/19/health/states-using-electronic-medical-records-to-track-epidemics.html http://www.nytimes.com/2012/06/19/health/states-using-electronic-medical-records-to-track-epidemics.html http://www.webcitation.org/6ggqxvcox http://www.cdc.gov/phpr/pubs-links/2012/index.htm http://www.webcitation.org/6ggr5a6r9 http://www.whitehouse.gov/omb/circulars_a087_2004 http://www.webcitation.org/6ggrbjksm steps to a sustainable public health surveillance enterprise 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [38] thriemer k, ley b, ame sm, et al. replacing paper data collection forms with electronic data entry in the field: findings from a study of community-acquired bloodstream infections in pemba, zanzibar. bmc research notes. 2012;5(1):113. [39] hopkins rs. design and operation of state and local infectious disease surveillance systems. j public health manag pract. 2005;11(3):184–190. [40] tilson h, berkowitz b. the public health enterprise: examining our twenty-first-century policy challenges. health aff. 2006;25(4):900–910. [41] baker el, potter ma, jones dl, et al. the public health infrastructure and our nation’s health. annu rev public health. 2005;26:303–318. [42] the department of health and human services. public health’s infrastructure, a status report to the u.s. senate appropriations committee, 2001. centers for disease control and prevention; 2001. a confidence-based aberration interpretation framework for outbreak conciliation a confidence-based aberration interpretation framework for outbreak conciliation 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 a confidence-based aberration interpretation framework for outbreak conciliation shamir nizar mukhi, phd 1 1 university of manitoba, public health agency of canada abstract: health surveillance can be viewed as an ongoing systematic collection, analysis, and interpretation of data for use in planning, implementation, and evaluation of a given health system, in potentially multiple spheres (ex: animal, human, environment). as we move into a sophisticated technologically advanced era, there is a need for cost-effective and efficient health surveillance methods and systems that will rapidly identify potential bioterrorism attacks and infectious disease outbreaks. the main objective of such methods and systems would be to reduce the impact of an outbreak by enabling appropriate officials to detect it quickly and implement timely and appropriate interventions. identifying an outbreak and/or potential bioterrorism attack days to weeks earlier than traditional surveillance methods would potentially result in a reduction in morbidity, mortality, and outbreak associated economic consequences. proposed here is a novel framework that takes into account the relationships between aberration detection algorithms and produces an unbiased confidence measure for identification of start of an outbreak. such a framework would enable a user and/or a system to interpret the anomaly detection results generated via multiple algorithms with some indication of confidence. keywords: health, surveillance, outbreak, bioterrorism, anomaly, syndromic, confidence, infectious disease 1. introduction recent advances in technology have made it possible to gather, integrate, and analyze large amounts of data in real-time or near real-time. these new technologies have touched off a renaissance in public health surveillance. for the most part, the traditional purposes of health surveillance have been to monitor long-term trends in disease ecology and to guide policy decisions. with the introduction of real-time capabilities, data exchange now holds the promise of facilitating early event detection and to assist in day-to-day disease management. with the availability of dozens of different aberration detection algorithms, it is possible, if not probable, to get different results from different algorithms when executed on the same dataset. the results of the study in [1] suggest that commonly-used algorithms for disease surveillance often do not perform well in detecting aberrations other than large and rapid increases in daily counts relative to baseline levels. a new approach, denoted here as confidence-based aberration interpretation framework (caif), may help address this issue in disease surveillance by using a collective approach rather than algorithm specific approach. 2. the problem statement consider a system with multiple anomaly detection algorithms as illustrated in figure 1. due to differences in the implementation of the algorithms and parameters used (ex: thresholds, training periods and averaging windows), the outbreak decisions may vary significantly from a confidence-based aberration interpretation framework for outbreak conciliation 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 one algorithm to another. on the other hand, there is also a possibility that these decisions are very similar for some set of algorithms. these two extremes create a dilemma for decision makers in that there could be a situation where most of the algorithms in a system suggest an outbreak, however, not knowing the relationships between these algorithms can result in a biased decision. figure 1. the outbreak detection problem as illustrated, there are three main points of concern: • false negative: depending on the algorithm employed, there is a possibility of missing a real outbreak indicated as 1 in figure 1. obviously, this can be very damaging if the system were to make a decision based on that specific algorithm. false negatives can lead to potentially exponential damage within the general public due to delayed response to an outbreak. • false positive: some algorithms are susceptible to reporting false positives, that is, detect an anomaly during peace time (indicated as 2 in figure 1). most systems set their anomaly detection thresholds to be as sensitive as possible to minimize the risk of missing important events, producing frequent false alarms, which may be determined to be false positives by subsequent investigation. these systems face inherent trade-offs among sensitivity, timeliness and number of false positives. false positives have a negative impact on public health surveillance because they can lead to expensive resource utilization for further investigation and can cause undue concern among the general public. • delayed identification: during initial stages of an outbreak, the number of cases are on the rise and hence detecting an outbreak at this point could be very effective and potentially aid in minimizing the impact of a potential bioterrorist attack. however, depending on the algorithm(s) employed, a system may end up with some algorithms detecting outbreaks well beyond the actual start day (indicated as 3 in figure 1). this, once again, can be very costly to public health community and impact it negatively for obvious reasons. these three concerns result in a trade-off situations between false positives, false negatives and detection time which are typically addressed by looking at sensitivity, specificity and time to detect parameters. a confidence-based aberration interpretation framework for outbreak conciliation 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 in summary, a framework needs to be implemented that would enable a user/system to interpret the anomaly detection results with some indication of confidence. that is, is there a potential start of an outbreak with twenty percent confidence or is it ninety percent confidence? a framework that takes into account the relationships between algorithms and produces an unbiased confidence measure for identification of start of an outbreak is presented. 3. the proposed solution the proposed anomaly interpretation framework aims to enhance surveillance decisionmaking by combining results of multiple aberration detection algorithms through the use of key result metrics. figure 2 depicts the four steps of the proposed framework and the associated linkages between them. figure 2. the confidence-based aberration interpretation framework a confidence-based aberration interpretation framework for outbreak conciliation 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 step 1: specificity, sensitivity and time to detect evaluator traditionally, specificity and sensitivity have been used for comparing various algorithms and their performances. in this study, these two parameters are key in helping identify a subset of algorithms (referred to as minimal set) that would be sufficient to deduce an overall decision to detect start of an outbreak. the hypothesis is that the system may not require all candidate algorithms to come up with a good decision as some of them may provide redundant information. sensitivity of an algorithm for a given dataset is defined as the total number of outbreaks during which the algorithm flagged (at least once per outbreak) divided by the total number of outbreak periods in the dataset 1 . specificity of an algorithm for a given dataset, on the other hand, is defined as the total number of non-outbreak days on which the method did not flag divided by the total number of non-outbreak days in that dataset [2]: ))/((= outbreaksofnumbertotalcountpositivetrueysensitivit ))/((= daysoutbreaknoofnumbertotalcountnegativetrueyspecificit in addition to specificity and sensitivity, a third parameter called time to detection (ttd) defined as the average number of days from the first day of an outbreak until it was flagged by the algorithm, plays a vital role in the forthcoming analysis. this is a very important parameter as it aids in segregating a set of algorithms into various groups (or classes) and provides a very clear differentiation between set of algorithms based on its interpretation. figure 3 illustrates, in time, a progression of a sample outbreak over multiple days. periods with no outbreaks are referred to as peace-time, while outbreak-mode refers to a time period with outbreak days. figure 3. a sample outbreak the three parameters discussed in this section provide a wealth of insight into the goal of 1 a single outbreak usually lasts more than one day a confidence-based aberration interpretation framework for outbreak conciliation 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 identifying a minimal sub set of algorithms sufficient for generating an overall confidence value for an anomaly indicator. step 2: agreement analyzer agreement analyzer deals with quantifying the degree of agreement or relationship between any given two algorithms executed on the same data set. that is, are all candidate algorithms producing unique results? or, is it that some algorithms yield similar results and thus provide no added value to the overall decision? this step of the framework exploits such relationship and/or agreement between any two algorithms using two quite different approaches: correlation and kappa coefficient. correlation correlation is one of the most common and most useful statistics. a correlation, r, is a single number that describes the degree of linear relationship between two variables (also referred to as bivariate relationship). a positive relationship, in general terms, means that higher scores on one variable tend to be paired with higher scores on the other and that lower scores on one variable tend to be paired with lower scores on the other. the correlation between two variables, in this case the two algorithm values or decisions, can be obtained using [3]: ])(][)([ ))(( = 2222 yynxxn yxxyn r where x and y are the time series for daily counts, n is the total number of days in the time series, xy is the sum of products of paired counts, x is the sum of counts from first algorithm in the pair, y is the sum of counts from second algorithm in the pair, 2 x is the sum of squared x counts and 2 y is the sum of squared y counts. ncorrelatio , the agreement matrix based on correlation, is obtained using the above formula as follows: nnnn n n ncorrelatio rrr rrr rrr 21 22221 11211 = where xy r is the correlation value for algorithm x against algorithm y and n is the number of algorithms in the candidate set. a minimum agreement threshold based on correlation ncorrelatio a t needs to be defined that can be used in the next step of the framework to identify nearest neighbors for each algorithm based on the strength of the relationships. a confidence-based aberration interpretation framework for outbreak conciliation 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 kappa coefficient an alternative approach to correlation matrix is the computation of kappa coefficient, which is an index that compares the agreement against that which might be expected by chance. kappa can be thought of as the chance-corrected proportional agreement, where possible values range from +1 (perfect agreement) via 0 (no agreement above that expected by chance) to -1 (complete disagreement). cohen's kappa coefficient approach [4] can be used to generate kappa coefficient matrix. consider a 2x2 table capturing decision outcomes by two different algorithms being compared as shown in figure 4. figure 4. kappa coefficient: 2 by 2 table the following formula was used to compute the kappa coefficient between any two algorithms: )(1 )( = c co p pp ,= t yynn p o t yyyn t yyny t ynnn t nynn p c **= where o p is the relative observed agreement and c p is the probability that the agreement is due to chance. kappa , the agreement matrix based on kappa coefficients, is obtained using the above formulas as follows: a confidence-based aberration interpretation framework for outbreak conciliation 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 nnnn n n kappa 21 22221 11211 = where xy is the kappa coefficient for algorithm x against algorithm y and n is the number of algorithms in the candidate set. once the kappa matrix has been computed, it is necessary to consider the significance of obtained agreement values between any pair of algorithms. landis and koch [5] give the following table for interpreting the significance of the value. although inexact, this table provides a useful benchmark on the significance of the above matrix. interpretation negative poor agreement 0.0 0.20 slight agreement 0.21 0.40 fair agreement 0.41 0.60 moderate agreement 0.61 0.80 substantial agreement 0.81 1.00 almost perfect agreement based on the results and table above, the minimum agreement threshold based on kappa kappa a t can be deduced, which can be set to 0.5 based on the above table. this is the value that will be used in the next step of the framework to identify nearest neighbors for each algorithm based on the strength of the relationships. step 3: minimal set identifier once the sensitivity, specificity and time to detect parameters are well established for each algorithm and the agreement levels between every possible algorithm pair is known, a minimal set of algorithms can be identified that would be sufficient to produce quantifiable confidence value for the overall decision. figure 5 illustrates a five-step process developed to identify this minimal set based on results from the previous two steps of the proposed framework. a confidence-based aberration interpretation framework for outbreak conciliation 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 5. minimal set identification process • task 1: this task is basically setting up the agreement matrix generated from step 2 of the framework. that is, initialize with computed ncorrelatio or kappa values. note that only the upper triangle of the matrix needs to be analyzed to avoid any recursive relationships between two algorithms. that is, if a1 highly correlated to a2, then a2 is highly correlated with a1. • task 2: the next task deals with setting up the closest relative matrix. a closest relative to a specific algorithm x is algorithm y that has an agreement value of at least some minimum agreement threshold ( a t ) and has the highest agreement value with respect to x against all other algorithms within the set. the idea is that for each algorithm in the set, a corresponding algorithm with highest agreement value must be identified. it is entirely possible that a specific algorithm will not have a closest relative. in that case, the algorithm would be considered as an independent and thus needs to be included for next filtration task. for example, in the illustrated figure, a2 is closest relative to a1 as an is to a3. however, algorithms a2 and an are independent. • task 3: this task simply formalizes the algorithms that were selected in the previous task by removing all the algorithms from the closest relative matrix that have relatives identified, that is, the non-independent algorithms. this produces a working set of algorithms identified as 1 in the 1xn matrix. • task 4: the next task is to categorize the algorithms from the working set into three a confidence-based aberration interpretation framework for outbreak conciliation 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 groups based on ttd value. the ttd was divided into three sets: close to zero days (ttd 0.1), less than one day (0.1 ttd 1.0) and greater than one day (ttd 1.0). this categorization makes intuitive sense because typically one would be interested in ttd value of less than a day. optimally, ttd should be as close to zero as possible, but realistically, public health individuals typically identify an outbreak more than a day later. • task 5: once the groups have been identified, the final task deals with identifying the minimal set of algorithms through one more stage of filtration using specificity and sensitivity values obtained from step one of the framework. this task scans through each of the groups and attempts to flag algorithms that have both highest sensitivity and highest specificity when compared to other algorithms in the same group. if one algorithm has higher sensitivity but some other algorithm has higher specificity, then both the algorithms need to be considered. this step of the framework yields a minimal subset of candidate algorithms that have minimal relation with each other and thus, form close to an independent minimal set that would be sufficient to deduce a confidence measure for an outbreak decision for a given day. step 4: point-based confidence evaluator the final step of the proposed framework deals with pulling together the findings from the first three steps and working out a scheme that produces a value that corresponds to overall confidence. there are three main parameters that need to be investigated. parameters of interest: rise rate the first parameter is the rate of change (referred to as rise rate) of actual daily count values over a specific time period, which provides some basic knowledge of the positive or negative trend over the last few days and also yields the speed with which the change is occurring. figure 6. rise rate analysis figure 6 illustrates a typical snapshot from daily counts data where the y-axis represents daily raw count and the x-axis represents the day with )(d representing the current day. the rate of change ( ) is computed using basic linear regression method [6] to define a line that fits the daily count values in best possible manner: a confidence-based aberration interpretation framework for outbreak conciliation 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 22 )( = xxn yxxyn where n is the number of points being considered, x is the day and y is the count. to be effective, the computation of rate is limited to a specific time frame referred to as an epidemiologically significant window, , which is defined in number of days. parameters of interest: count delta next parameter of interest is analyzing the importance of the current day's count with respect to . that is, does today's count follow a typical trend identified by the linear regression or is it drastically different and thus deserves special attention. as shown in figure 7, there could be a scenario where past ( 1) values yield a negative direction, however current day's value ( h ) is very high but cannot influence the linear regression formula to produce a positive slope which is more accurate in this case. figure 7. count delta for such cases, the framework takes into account a second parameter of interest called count delta ( ). this value is simply the ratio between current day value, h , and the average value over . i ii ii x h = 1= 1 = where i is the current day and i x is the time series for daily counts. parameters of interest: outbreak decisions based on the output of step three of the framework, the individual outbreak decision flags need to be considered. these provide the third parameter of interest, i , where i refers to the algorithms in the minimal set. each i can have one of two values: true representing an outbreak has been detected by algorithm i and false representing no outbreak decision by algorithm i . a confidence-based aberration interpretation framework for outbreak conciliation 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 point system: rules the overall objective of the framework is to produce a set of algorithms, that is as minimal as possible, to evaluate an aberration decision for any given day with some confidence value. due to availability of multiple algorithms, a system that facilitates incremental confidence building based on contributions from various algorithms needs to be developed. a bimodal approach to confidence evaluation is proposed to address this issue as shown in figure 8. this bimodal approach is based on the concept of contribution to positive and negative confidence of a decision. the fundamental premise of the proposed scheme is a rule set, which is defined as the set of rules that collectively contribute to either positive or negative confidence. positive confidence is a measure of collective strength of rules that contribute to a decision that supports identification of start of an outbreak. on the other hand, negative confidence is a measure of collective strength of rules that contribute to a decision that is against the decision of start of an outbreak. rule sets are made of weighted combination of identified parameters of interest. further discussion on details of rule sets will follow shortly. once the rule set has been identified, appropriate weights (or points) are assigned to the members of the rule set contributing to either side. a set of rules that contribute to positive confidence by collective summation of all of their respective points ( p ) are referred to as the r set. on the contrary, a set of rules that contribute to negative confidence by collective summation of all of their respective points ( n ) are referred to as the l set. that is, each side adds its collective contribution followed by )( np to come up with overall confidence with 0 as the no decision point. figure 8. point assignment scheme the following rules contribute to incremental positive confidence (r side rules): 1 1 *> *> = dud dud i t t kitrue where d is the current day and k is the number of algorithms in the minimal set. that is, there are 2k rules that contribute to positive confidence with each rule having a point magnitude of k p , where k (k+2). the following rules contribute to incremental negative confidence (l side rules): a confidence-based aberration interpretation framework for outbreak conciliation 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 1 1 *< *< = ddd ddd i t t kifalse where d is the current day and k is the number of algorithms in the minimal set. that is, there are 2k rules that contribute to positive confidence with each rule having a point magnitude of k p , where k (k+2). the use of and requires introduction of some threshold value that defines the decision points in both the upward and downward directions. thus, the scheme makes use of u t parameter for the positive (or upside) threshold value and d t for the negative (or downside) threshold value. both of these values can be computed using sophisticated approaches like neural networks, however, a simple intuitive approach using hysteresis (figure 9) was adopted. that is, and would contribute to positive confidence if the current day values were at least u t times bigger than the previous day values. however, they would only contribute to negative confidence if the current day values were less than d t times previous day values. this approach assists in identifying abrupt rises and falls in the count values with respect to immediate history. the proposed rule of thumb is to use du tt *3 . figure 9. threshold hysteresis to summarize, there are total of 2)2(= kz rules that define a specific rule set i for a given point assignment i . in an attempt to simply the representation of rules and associated point assignments for l and r rules, a concise convention was designed as follows: pv pv l p p l p p l p p l p p l p p li r v rrrrr ,,,5,4,3,21= 5 5 4 4 3 3 2 2 1 1 where numbers 1 to v represent the v 2)(= k rules, pv l is the point assignment for the a confidence-based aberration interpretation framework for outbreak conciliation 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 vth left rule and pv r is the point assignment for the vth right rule. with 2 z possible rules on each side, the most obvious choice is a balanced system with the maximum number of points for negative confidence and the maximum number of points for positive confidence to equal multiple of 2 z . that is, if both sides matched in their outcomes, then the overall confidence value would equate to 0, an indecisive line. to facilitate wider base of different points and associated effects on overall decision, a system that exercises the point assignment with an unbiased (random) allocation of points is necessary. however, before such a system can be developed, the value of maximum points for each side ( m ) needs to be established. this can be achieved as follows: mp i z i = 1= where i p represents point allocation for th i rule. figure 10. maximum number of points in figure 10, x-axis represents m and y-axis represents the total number of point assignment possibilities for z = 12 (that is, k = 6). in this specific case, m = 12 seems reasonable as it is located at the knee of the rising curve and provides 6188 assignment possibilities, a number that is quite reasonable for simulation purposes. now that the rules and point assignment method have been designed, there is a need for devising a system that interprets outcomes of the application of identified rules and associated points and yields an optimal point assignment that produces desired outcome. the proposed approach is to group sensitivty and specificity values obatined using numerous random point assignments into clusters of interest as shown in figure 11. the idea is to identify specific areas of interest (aoi) on this scatter plot that produce outcome that is superior when compared to any single algorithm. that is, three aois are identified as follows: high specificity (left top); high sensitivity (bottom right) and maximum sensitivity/specificity (knee). a confidence-based aberration interpretation framework for outbreak conciliation 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 11. clusters any of the commonly used clustering techniques may be used to identify aois. the proposed approach utilizes k-means clustering [7] technique as it allows identification of initial centroids of desired clusters, which is attractive since, as discussed above, typically one would like to look at very specific clusters that provide, for instance, high specificity and high sensitivity that is, aoi(3). the objective of k-means approach is to minimize total intra-cluster variance, or, the squared error function: 2 1= ||= ij ij x k i x s v where there are k clusters kis i ( ), j x is the sensitivity/specificity pair on the scatter plot corresponding to i and i is the centroid or mean point of all the points within cluster i . application of clustering methodology yields a multitude of rule sets i each of which produce a sensitivty/specificity pair i yielding: ki i k ,= once k has been figured out, the idea is to then pick an appropriate rule set in a given cluster k that falls in the desired aoi and use it for computing the overall confidence value. note that one could develop an algorithm to identify an optimal point assignment within a cluster. 4. nomenclature the proposed caif framework utilizes a number of variables as follows: • n is the number of algorithms in the candidate set. • is the agreement matrix between all pairs of algorithms within the candidate set. • a t is the minimum agreement threshold used to identify nearest neighbors. • k is the number of algorithms in the minimal set. a confidence-based aberration interpretation framework for outbreak conciliation 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 • z is the total number of positive and negative rules. • m is the maximum number of points typically a multiple of 2 z . • u t is the positive (or upside) threshold value for point assignment scheme. • d t is the negative (or downside) threshold value for point assignment scheme. • is the epidemiologically significant window in days. • is the rate of change of actual daily count values over a specific time period . • is the relation of the current day's count with respect to . • j is the individual algorithm's outbreak decision flag based for a specific algorithm j within the minimal set. • i is the rule set based on minimal set and specific point assignment i . • i is the sensitivity/specificity pair computed for a specific rule set i . • k is a set of sensitivity/specificity pairs computed for all point assignments within a cluster k . based on this list, the following set, referred to as caif parameters, needs to be populated using various steps of the framework: ,,,,,,,= dua ttzktnvariablescaif with following parameters: j parameterscaif ,,= and following output values: k i i outputscaif ,,= using the above nomenclature, the proposed four-step framework can be outlined as follows: step 1: (a) identify outbreak data set(s) (b) initialize candidate algorithm set define n (c) compute sensitivity, specificity and time-to-detect for each algorithm step 2: compute agreement analyzer ( ncorrelatio or kappa ) define and a t step 3: execute minimal set identification process define k , z and m step 4: (a) setup inputs to point assignment scheme: define u t , d t , a confidence-based aberration interpretation framework for outbreak conciliation 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 (b) compute , and j (c) execute randomized strategy to obtain i compute specificity/sensitivity pairs i (d) apply clustering technique(s) to generate k (e) compute overall confidence value utilizing one of the rules sets in k 5. simulation results a simulation environment was setup that comprised of custom simulator for some aspects of the proposed approach as well as an open source package (r [8]) to compute various statistical and epidemiological parameters used in the proposed approach. the data for simulation were obtained from cdc [2]. nine candidate algorithms were selected based on literature review of most commonly used aberration detection algorithms: 3-day (ma3), 5-day (ma5) and 7-day (ma7) moving average, weighted moving average (wma), exponentially weighted moving average (ewma), cumulative sum (cusum) and early aberration reporting system c1-c3 [9]. the epidemiological parameters (sensitivity, specificity and time to detect) were computed using the simulation environment. a minimal set using step 3 of the proposed framework was identified as [wma, cusum, c1, c3]. the caif variable list was found to be: 7=12,=0.5,=1.15,=6,=4,=0.5,=,=9,= mttzktn duakappa the caif simulator was setup to perform numerous iterations to produce a large variety of point assignment using randomized point assignment strategy where only unique combinations of points for each set were allowed. this produced a scatter plot of specificity against sensitivity, over which k-means clustering was applied to identify points that lie within the desired aois (figure 12). figure 12. identified areas of interest a confidence-based aberration interpretation framework for outbreak conciliation 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 from table 1, the three clusters of interest representing the aois were 2, 5 and 10 with the following centroids (98.35, 53.42), (66.50, 94.63) and (86.89, 94.41). for aoi(1), none of the point assignments provided a better result than simply running wma algorithm which yielded (99.17, 52.12) as the specificity and sensitivity values. thus, the conclusion was that the proposed framework does not provide any benefit in cases when highest possible specificity is desired. on the other hand, for aoi(2), the identified centroid of (66.50, 94.63) provided a cluster with about 125 point assignments some of which provided better results than any single algorithm. table 1. cluster centres cluster specificity (%) sensitivity (%) 1 92.94 88.15 2 98.35 53.42 3 84.93 92.50 4 90.15 87.38 5 66.50 94.63 6 88.28 90.78 7 94.52 54.74 8 89.10 54.39 9 81.46 95.92 10 86.89 94.41 for aoi(3), the identified centroid of (86.89, 94.41) is quite close to the result produced by ears c3 algorithm. however, this cluster has over 200 point assignments some of which yield higher sensitivity and specificity values than ears c3 which provides the best pair from all algorithms in the candidate set. for example, the following rule set yields (86.39, 95.50): 2 1 5 3 3 0 2 1 0 6 0 1 ,6,5,4,3,21 which translates to positive confidence associated with the following rules, pointst pointst pointstrue pointstrue pointsna pointsna ddd r dud r c r wma r r r 2*>:6 5*>:5 3=:4 2=:3 0:2 0:1 1 1 1 negative confidence points associated with the following rules, a confidence-based aberration interpretation framework for outbreak conciliation 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 pointt pointst pointsna pointfalse pointsfalse pointfalse dddl dudl l wmal cl cusuml 1*<:6 3*<:5 0:4 1=:3 6=:2 1=:1 1 1 3 note that each side of the rule set contributes a maximum of 12=m points providing an overall confidence measure ranging from -12 (100% negative confidence) to +12 (100% positive confidence). next, one of the rule sets from the aoi(3) cluster were applied to a sample outbreak within the simulated data sets and confirm its effectiveness. (figure 13) illustrates a snapshot that superimposes daily counts during outbreak mode along with computed confidence measure using the above rule set. figure 13. simulated outbreak analysis as shown, the framework suggests an outbreak day with confidence measure of +1 ( 12 1 or 8.33% positive confidence) on day 6, a day before an outbreak is going to start (point a). although a false positive decision, it is a weak false positive that aids in planning for the following day which will have a strong positive confidence measure of +7 translating to 12 7 or 58.3% positive confidence (point b). this is exactly what the aim of this framework was set to be, that is, identify start of an outbreak with some level of confidence measure at an early stage. further to note, as the outbreak progresses, the confidence seems to drop to negative values. this is because the framework is intended to monitor initial start of an outbreak. as the values stabilize during an outbreak, the confidence measure of start of an a confidence-based aberration interpretation framework for outbreak conciliation 19 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 outbreak will diminish as expected. a detailed step by step simulation results for the proposed framework have been provided in [10]. 6. real scenario the rule set for aoi (3) from previous section was applied to a subset of real emergency room visit data from the canadian early warning system (cews). as shown in figure 14, one of the key observations is that the indication that an outbreak is going to occur in the next few days was identified by a higher confidence value on day 8, which was most likely the first day of an outbreak curve with peak on day 11. further, the confidence measure was computed based on a minimal set identified by the proposed framework and not the entire set of nine algorithms. that is, the minimal set identified by the proposed framework was sufficient to detect the start of an event a few days earlier than it was actually detected. the following is some analysis of some of the days with interesting observations. day 8: three of nine algorithms suggest an outbreak out of which two are from the identified minimal set. looking at this at face value would produce a biased decision that we had no signs of start of an outbreak on day 8. however, considering only the minimal set, there is a split decision, and using the proposed point assignment system a confidence measure of +5 translating to 5/12 or 41.7% positive confidence is produced. thus, there were clear signs for start of an outbreak on that day as suggested by a strong confidence value. day 9: the confidence value drops drastically to just above the 0 or no decision line. this is due to the actual count staying at similar level as the count for previous day thus the λ and ω values did not change much and did not contribute to the overall confidence value as strongly as they did on the previous day. however, the confidence value still stayed above zero point indicating some level of activity. day 11: this is the day when the counts of cases during an outbreak are the highest. all four algorithms of the minimal set declare an outbreak, however, the framework produces confidence measure of only +5. this is because the framework is monitoring start of an outbreak and not necessarily the peak. at the peak, both λ and ω do not contribute their portion to the overall confidence measure since neither the recent most count nor the count delta satisfy the rules as defined in the positive set. using the proposed framework, the identification with significant confidence would have been detected on day 8 and initial start of some activity instead of delayed identification which most likely occurred on day 11. a confidence-based aberration interpretation framework for outbreak conciliation 20 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 14. application of ciaf to real scenario 7. limitations the following list highlights some limitations of the proposed framework and thus potential areas for future research: 1. identification of optimal rule: the proposed framework employs basic techniques for clustering and point identification. use of more sophisticated clustering techniques as well as optimal point identification systems to come up with best rule to use within a given area of interest. 2. further generalization: it would be useful to implement of other versions of exponential smoothing schemes which include seasonality corrected approach and apply to the overall framework. a confidence-based aberration interpretation framework for outbreak conciliation 21 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 3. time effect: taking into account time of day, day of week, week of month and month of year within the framework and use it to deduce further redundancy between various algorithms. 4. data labeling: a feedback mechanism for public health specialists to close the loop for labeling outbreaks and no-outbreak decisions. this will extend the framework to allow for other techniques for evaluation purposes. 5. invariant minimal set: there is no question that some algorithms are better than others when looking at different disease outbreaks. applying a variety of outbreak types to the data (beyond log normal, daily spikes, etc) will help in figuring out if the minimal set produced by the framework is invariant. 8. conclusion a novel aberration interpretation framework has been proposed for producing a confidence based system decision focusing on high confidence values at the start of an outbreak. the framework comprises of multiple steps to allow identification of a subset of algorithms as well as a dynamic point assignment scheme for computing a balanced decision. the proposed framework provides a multitude of benefits: • savings in the computation effort by identifying only a smaller subset of algorithms that are necessary and sufficient for a sound system decision. • provides a mechanism to derive confidence value based on dynamic point assignment system. • produces a superior overall system decision within desired aoi when compared to any single algorithm. • provides a framework for future research to investigate optimal point allocation systems as well as analysis of new algorithms and their effects on the overall decision. the proposed framework is also adaptable or extensible. it captures the essential elements of a confidence based decision process. acknowledgement many thanks to dr robert mcleod of electrical and computer engineering department at the university of manitoba for his support and guidance throughout the course of this research. contact shamir nizar mukhi, phd email: shamir.nizar.mukhi@phac-aspc.gc.ca references [1] jackson m, baer a, painter i and duchin j. a simulation study comparing aberration detection algorithms for syndromic surveillance. bmc medical informatics and decision making. vol. 7. 2007. [2] centre for disease control (cdc). data sets. available at: http://www.bt.cdc.gov/surveillance/ears/datasets.asp. [3] trochim w. correlation. available at: mailto:shamir.nizar.mukhi@phac-aspc.gc.ca http://www.bt.cdc.gov/surveillance/ears/datasets.asp a confidence-based aberration interpretation framework for outbreak conciliation 22 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 http://www.socialresearchmethods.net/kb/statcorr.htm [4] jacob c. a coefficient of agreement for nominal scales. educational and psychological measurement. vol. 20, pp. 37–46. 1960. [5] landis j and koch g. the measurement of observer agreement for categorical data. biometrics. vol. 33, no. 1, pp. 159-174. 1977. [6] waner s and costenoble s. linear regression. available at: http://people.hofstra.edu/faculty /stefan_waner/realworld/tutorialsf0/ frames1_5.html. [7] wikipedia. k-means algorithm. available at: http://en.wikipedia.org/wiki/kmeans_algorithm [8] the r package for statistical computing. available at: http://www.r-project.org/ [9] hutwagner l, thompson w, seeman g and treadwell t. the bioterrorism preparedness and response early aberration reporting system (ears). journal of urban health: bulletin of the new york academy of medicine. vol. 80 no. 2, supplement 1. pp. i89-i96. 2003. [10] mukhi s. an integrated approach to real-time biosurveillance in a federated data source environment. phd thesis, university of manitoba. june 2007. http://www.socialresearchmethods.net/kb/statcorr.htm http://people.hofstra.edu/faculty http://en.wikipedia.org/wiki/k-means_algorithm http://en.wikipedia.org/wiki/k-means_algorithm http://www.r-project.org/ layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a review of evaluations of electronic event-based biosurveillance systems kimberly gajewski*1, jean-paul chretien2, amy peterson2, julie pavlin3 and rohit chitale2 1emory university, atlanta, ga, usa; 2division of integrated biosurveillance, silver spring, md, usa; 3headquarters, armed forces health surveillance center, silver spring, md, usa objective to assess evaluations of electronic event-based biosurveillance systems (eebs’s) and define priorities for eebs evaluations. introduction eebs’s that use near real-time information from the internet are an increasingly important source of intelligence for public health organizations (1, 2). however, there has not been a systematic assessment of eebs evaluations, which could identify uncertainties about current systems and guide eebs development to effectively exploit digital information for surveillance. methods we searched pubmed and consulted eebs experts to identify eebs’s that met the following criteria: uses publicly-available internet info sources, includes events that impact humans, and has global scope. we constructed a list of 17 key evaluation variables using guidelines for evaluating health surveillance systems, and identified the key variables included in evaluations per eebs, as well as the number of eebs’s evaluated for each key variable (3,4). results we identified 10 eebs’s and 17 evaluations (table 1). the number of evaluations per eebs ranged from 1 (gen-db, godsn) to 7 (gphin, healthmap). the median number of variables assessed per eebs was 6 (range, 3-12), with 5 (25%) evaluations assessing 7+ variables. nine (53%) published evaluations contained quantitative assessments of at least 1 variable. the least-frequently studied variable was cost. no papers examined usefulness as specific public health decisions or outcomes resulting from early event detection, though 8 evaluations assessed usefulness by citing instances where the eebs detected an outbreak earlier, or by eliciting user feedback. conclusions while eebs’s have demonstrated their usefulness and accuracy for early outbreak detection, no evaluations have cited specific examples of public health decisions or outcomes resulting from the eebs. future evaluations should discuss these critical indicators of public health utility. they also should assess the novel aspects of eebs and include variables such as policy readiness, system redundancy, input/output geography (5); and test the effects of combining eebs’s into a “super system”. table 1. number of published evaluations and variables on identified eebs’s table 2. key variables used in evaluations of eebs keywords evaluation; biosurveillance; event-based surveillance references heymann dl, et al. hot spots in a wired world: who surveillance of emerging and re-emerging infectious diseases. lancet infect dis. 2001;1:345–53. keller m, et al. use of unstructured event-based reports for global infectious disease surveillance. emerg infect dis. 2009;15:689–95. german rr, et al. guidelines working group centers for disease control and prevention (cdc).updated guidelines for evaluating public health surveillance systems: recommendations from the guidelines working group. mmwr recomm rep. 2001;50(rr-13):1–35. buehler jw, et al. framework for evaluating public health surveillance systems for early detection of outbreaks: recommendations from the cdc working group. mmwr recomm rep. 2004;53(rr-5):1–11. corley cd, et al. assessing the continuum of event-based biosurveillance through an operational lens. biosecur bioterror 2012;10:131-141. *kimberly gajewski e-mail: kimberly.gajewski@emory.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e131, 2013 editorial: vol 2, no 2 (2010) 1 journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 editorial: vol 2, no 2 (2010) the major challenges facing the u.s. healthcare systems are escalating costs, lack of access to almost 40 million residents, and inconsistent quality. it is hypothesized that the use of electronic health records systems and the implementation of interoperable health information exchanges (hie) will result in significant cost savings, outcomes and quality improvement, reduction in medical errors and redundancies, and the enhancement of public health and disease surveillance. hies are organizations that facilitate secure health data exchanges among consenting and authorized stakeholders. the ultimate result of the current unprecedented increase in the investment in health information technology is the transformation of the u.s. healthcare system. in order to achieve such a transformation and the attendant benefits the health information technology for economic and clinical health act (hitech) of the american recovery and reinvestment act of 2009 allocated over 30 billion dollars to the states to encourage the use of electronic health records and develop interoperable health information exchanges. what is the public health case for participating in the implementation of the health information exchanges? the occurrences of major public health threats in recent years have highlighted the need for integrating public health data sources and surveillance systems into the emerging health information exchanges. such an integrated system will facilitate the timely distribution and sharing of relevant health data across the various stakeholders such as public health practitioners, clinicians, and policy makers, and payers. data sharing will improve the situational awareness operations of the stakeholders and lead to improved decision making regarding the control of emergencies, treatment of individual cases, and efficient resource allocation. if public health practitioners are aware of the critical events in a region but the information is not available to clinicians at a place and time when it could be utilized, then the information is of limited value. to encourage the adoption of hie-supported situational awareness among healthcare stakeholders the centers for disease control and prevention (cdc) awarded three hie grants to recipients from indiana, new york, and washington state-idaho. the awardees were charged with investigating and developing methods for sharing information between public health and clinical practitioners to support situational awareness and case reporting. this special issue of the journal is dedicated to disseminating the achievements of the awardees in terms of articles published, conferences attended, technologies implemented, and lessons learned. the indiana coalition (made up of university of indiana, marion county health department ( mchd), and regenstrief institute), among other achievements, demonstrated a novel approach for sending public health alerts to providers by leveraging an electronic clinical messaging system within a health information exchange. hies, in their current formats, assure that clinical information is sent to the intended providers in a timely manner at the appropriate location, with the capability to provide feedbacks to the senders. this later feedback capability is quite important because receipt and utilization of the health data can be verified. by delivering public health alerts using the existing health information exchanges the process of introducing the alerts editorial: vol 2, no 2 (2010) 2 journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 2, 2010 into the workflows of the clinicians is optimized, thereby improving the chances that the information will be utilized for clinical decision making. the washington-idaho partnership (the northwest public health information exchange: nwphie), developed an algorithm for sending syndromic surveillance feeds from hospitals to public health in washington state. the partnership also developed an automated process for performing electronic laboratory reporting (elr) for notifiable disease conditions in washington state. the automated elr system and the syndromic surveillance data feeds will be very essential in the management of disease outbreaks in the future. the emergency preparedness of public health officials in indiana and washington state will be greatly improved with the implementation of the technologies developed from the grants. by facilitating communication between public health and clinical stakeholders the projects have the potential to improve process efficiency, reduce costs, and provide quality data on notifiable disease conditions to public health for the development of surveillance systems. the bidirectional communication has the added benefit of creating trust among the stakeholders, a very important factor for successful adoption of health information systems. the projects presented in this issue demonstrate the value to public health agencies, clinicians, individuals, and the general community, of using health information exchanges to deliver targeted health messages to stakeholders. as more states receive funding from hhs and prepare to develop hies, it is important for the public health stakeholders to study the novel technologies developed by the awardees of the situational awareness grant in order to improve the value of their participation in the hie development process. a major issue unaddressed in the situational awareness projects is how the integrated public health-hies will be sustained after the start-up money runs out. to address the sustainability question it is important to estimate the value of hies to the different stakeholders and institute cost-recovery charges in proportion to the accrued benefits. while this will be a difficult exercise for the public health sector, due to the externalities involved, the private benefits to the clinicians and hospitals could be estimated. for example, the ability to electronically access important test results at the point of care without relying on the postal services or faxes results in time savings, reduced errors rates, and improvements in quality of care. these benefits are quantifiable. to develop a sustainable and integrated system these and other benefits should be estimated, at least for the clinical health sector, and cost-recovery charges implemented. rebecca roberts, md ojphi special issue editor research director, department of emergency medicine john stroger hospital of cook county chicago. il. 60612 email: rroberts@ccbh.org phone: (312) 864-0095 edward mensah, phd editor-in-chief online journal of public health informatics 1603 w taylor st, rm 757 chicago. il. 60612 email: dehasnem@uic.edu office: (312) 996-3001 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts one world, one health, one medicine: an assessment of intersectoral collaboration in avian influenza control in lagos state abimbola aman-oloniyo*1, olalekan allison2 and musbau a. razaq3 1lagos state ministry of health, nigeria; 2lagos state ministry of agriculture and cooperatives, nigeria; 3lagos state ministry of information, nigeria objective to assess the collaborative efforts in avian influenza control that could be harnessed for the control of other zoonotic diseases. introduction the livestock sector is vital to the socio-economic development of nigeria; it contributes about 9-10% of agricultural gdp. livestock represents an important source of high quality animal protein providing about 36.5 % of total protein intake of nigerians (1). lagos state, located in the south-western part of nigeria, has the smallest landmass (3577 sq. km) and the highest human population density (2519.75 per sq. km) in the country (2). the state has a poultry population of 2.5 million birds and the largest outlet for poultry products with 207 live bird markets, 375 poultry farms and a large number of poultry products consumers (3). avian influenza (“bird flu”) is an infectious disease of birds caused by type a strains of the influenza virus. the infection is known to cross species barrier to infect humans (4). between march 2006 and september 2007 avian influenza (ai) outbreaks occurred in 99 poultry farms in lagos state (3). the only human case of ai in nigeria was detected at a health facility in lagos in january 2007. methods following the ai outbreaks in nigeria, a lot of human and material resources were devoted to the control of ai in the health, information and veterinary sectors at all levels of administration. a desk review of the ai response activities and collaborative efforts at the state level was conducted. results the inter-ministerial state steering committee and state technical committee on avian influenza (stcai) were established comprising of stakeholders in the health, information and veterinary sectors drawn from public and private institutions. a number of interventions were carried out including formation of public enlightenment, health and veterinary sub-committees to deal with sector-specific issues. also, reconstitution and training of state and local council epidemic response teams (ert), training/retraining of state and local council health, information and veterinary officers on epidemic preparedness and response to avian influenza, establishment and equipping of desk offices in the state departments of health, veterinary and information, and appointment of ai desk officers the local council level. these interventions facilitated the conduct of joint surveillance of poultry and live bird markets by stakeholders, joint outbreak investigation and response, joint sensitization of human and animal health workers on ai, joint public enlightenment and community/grassroots mobilization activities (including advocacy visits to local government council administrators, traditional leaders and trade union leaders) on avian influenza control. all of these were instrumental in the quick containment of ai in lagos state. conclusions the collaboration between health, information and veterinary departments following the ai epidemic helped to curb the disease within the state. a good structure has been put in place for control of ai that can be harnessed for the control of other zoonotic diseases in the spirit of one world, one health, one medicine (owohom). figure 1. clinico-epidemic curve of the investigated human case of avian influenza. keywords collaborate; avian influenza; zoonotic references 1. the integrated national avian and pandemic influenza response plan, 2007. 3, 19 23 2. reducing health disparities in lagos statean investment case, 2012. 7-8 3. lagos state ministry of agriculture and cooperatives, 2009. 4. world health organization. avian influenza fact sheet. . accessed july 30, 2007. 5. world health organization. cumulative number of confirmed human cases of avian influenza a/(h5n1) reported to who. . accessed july 30, 2007. *abimbola aman-oloniyo e-mail: bimskoms@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e188, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts disease models for event prediction courtney d. corley*1 and laura pullum2 1pacific northwest national laboratory, richland, wa, usa; 2oak ridge national laboratory, oak ridge, tn, usa objective the objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. introduction one of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information to decision makers, in order to identify areas for future research. two critical characteristics differentiate this work from other infectious disease modeling reviews [1,2]. first, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. second, we considered models involving pathogens of concern as determined by the us national select agent registry. background: a rich and diverse field of infectious disease modeling has emerged over the past 60 years and has advanced our understanding of populationand individual-level disease transmission dynamics, including risk factors, virulence and spatio-temporal patterns of disease spread. recent modeling advances include biostatistical methods, and massive agent-based population, biophysical, ordinary differential equation, and ecological-niche models. diverse data sources are being integrated into these models as well, such as demographics, remotely-sensed measurements and imaging, environmental measurements, and surrogate data such as news alerts and social media. yet, there remains a gap in the sensitivity and specificity of these models not only in tracking infectious disease events but also predicting their occurrence. methods we searched dozens of commercial and government databases and harvested google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, this returned 13,767 webpages and 12,152 citations. after de-duplication and removal of extraneous material, a core collection of 6,503 items was established, these publications and their abstracts are presented in a semantic wiki at http://biocat.pnnl.gov. next, pnnl’s in-spire visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model. as a result, we systematically reviewed 44 papers, and the results are presented in this analysis. results the models were classified as one or more of the following types: event forecast (9%), spatial (59%), ecological niche (64%), diagnostic or clinical (14%), spread or response (20%), and reviews (7%). the distribution of transmission modes in the models was: direct contact (55%), vector-borne (34%), wateror soil-borne (16%), and nonspecific (7%). the parameters (e.g., etiology, cultural) and data sources (e.g., remote sensing, ngo, epidemiological) for each model were recorded. a highlight of this review is the analysis of verification and validation procedures employed by (and reported for) each model, if any. all models were classified as either a) verified or validated (89%), or b) not verified or validated (11%; which for the purposes of this review was considered a standalone category). conclusions the verification and validation (v&v) of these models is discussed in detail. the vast majority of models studied were verified or validated in some form or another, which was a surprising observation made from this portion of the study. we subsequently focused on those models which were not verified or validated in an attempt to identify why this information was missing. one reason may be that the v&v was simply not reported upon within the paper reviewed for those models. a positive observation was the significant use of real epidemiological data to validate the models. even though ‘validation using spatially and temporally independent data’ was one of the smallest classification groups, validation through the use of actual data versus predicted data represented approximately 33% of these models. we close with initial recommended operational readiness level guidelines, based on established technology readiness level definitions. keywords disease models; event prediction; operational readiness references [1] lloyd-smith jo, george db, pepin kp, pitzer ve, pulliam jrc, dobson a, hudson pj, and grenfell bt. epidemic dynamics at the human-animal interface. science 4 december 2009: 326 (5958), 1362-1367. [doi:10.1126/science.1177345] [2] bravata dm, sundaram v, mcdonald km, smith wm, szeto h, schleinitz md, et al. detection and diagnostic decision support systems for bioterrorism response. emerg infect dis [serial online] 2004 jan [9-sept 2012]. http://wwwnc.cdc.gov/eid/article/10/1/030243.htm *courtney d. corley e-mail: court@pnnl.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e180, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts identification and assessment of public health surveillance gaps under the ihr (2005) ngozi erondu*1, betiel hadgu haile1, lisa ferland1, meeyoung park1, affan shaikh1, heather meeks2 and scott jn mcnabb1 1public health practice, atlanta, ga, usa; 2defense threat reduction agency, washington, dc, usa objective to conceive and develop a model to identify gaps in public health surveillance performance and provide a toolset to assess interventions, cost, and return on investment (roi). introduction under the revised international health regulations (ihr [2005]) one of the eight core capacities is public health surveillance. in may 2012, despite a concerted effort by the global community, the world health organization (who) reported out that a significant number of member states would not achieve targeted capacity in the ihr (2005) surveillance core capacity. currently, there is no model to identify and measure these gaps in surveillance performance. likewise, there is no toolset to assess interventions by cost and estimate the roi. we developed a new conceptual framework that: (1) described the work practices to achieve effective and efficient public health surveillance; (2) could identify impediments or gaps in performance; and (3) will assist program managers in decision making. methods published articles and grey-literature reports, manuals and logic model examples were gathered through a literature review of pubmed, web of science, google scholar, and other databases. logic models were conceived by categorizing discrete surveillance inputs, activities, outputs, and outcomes. indicators were selected from authoritative sources or developed and then mapped to the logic model elements. these indicators will be weighted using the principle component analysis (pca), a method for enhanced precision of statistical analysis. finally, on the front end of the tool, indicators will graphically measure the surveillance gap expressed through the tool’s architecture and provide information using an integrated cost-impact analysis. results we developed five public health surveillance logic models: for ihr (2005) compliance; event-based; indicator-based; syndromic; and predictive surveillance domains. the ihr (2005) domain focused on national-level functionality, and the others described the complexities of their specific surveillance work practices. indicators were then mapped and linked to all logic model elements. conclusions this new framework, intended for self-administration at the national and subnational levels, measured public health surveillance gaps in performance and provided cost and roi information by intervention. the logic model framework and pca methodology are tools that both describe work processes and define appropriate variables used for evaluation. however, both require real-world data. we recommend pilot testing and validation of this new framework. once piloted, the framework could be adapted for the other ihr (2005) core capacities. keywords public health surveillance; evaluation; ihr (2005); gaps assessment; cost-impact analysis acknowledgments defense threat reduction agency and the world health organization references 1. implementation of the international health regulations., stat. resolution wha65.23 ( 26 may 2012 ). 2. may l, chretien jp, pavlin ja. beyond traditional surveillance: applying syndromic surveillance to developing settings—opportunities and challenges. bmc public health. 2009;9:242. epub 2009/07/18. 3. wilson k, mcdougall c, fidler dp, lazar h. strategies for implementing the new international health regulations in federal countries. bulletin of the world health organization. 2008;86(3):215-20. epub 2008/03/28. 4. organization wh. international health regulations (2005) second edition. 2008. 5. sturtevant jl, anema a, brownstein js. the new international health regulations: considerations for global public health surveillance. disaster med public health prep. 2007;1(2):117-21. epub 2008/04/05. 6. lyons s, zidouh a, ali bejaoui m, ben abdallah m, amine s, garbouj m, et al. implications of the international health regulations (2005) for communicable disease surveillance systems: tunisia’s experience. public health. 2007;121(9):690-5. epub 2007/06/05. 7. calain p. exploring the international arena of global public health surveillance. health policy plan. 2007;22(1):2-12. epub 2007/01/24. 8. baker mg, forsyth am. the new international health regulations: a revolutionary change in global health security. n z med j. 2007;120(1267):u2872. epub 2007/12/25. 9. cash ra, narasimhan v. impediments to global surveillance of infectious diseases: consequences of open reporting in a global economy. bulletin of the world health organization. 2000;78(11): 1358-67. epub 2001/01/06. 10. fidler dp. globalization, international law, and emerging infectious diseases. emerg infect dis. 1996;2(2):77-84. epub 1996/04/01. 11. organization wh. world health organization: disease surveillance. weekly epidemiological record [internet].1998. *ngozi erondu e-mail: ngozierondu@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e80, 2013 title: using secure web services to visualize poison center data for nationwide biosurveillance: a case study using secure web services to visualize poison center data for nationwide biosurveillance: a case study 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 using secure web services to visualize poison center data for nationwide biosurveillance: a case study thomas g savel 1 , alvin bronstein 2 , william duck 1 , m. barry rhodes 1 , brian lee 3 , john stinn 3 , katherine worthen 4 1 centers for disease control and prevention, atlanta, ga 2 rocky mountain poison and drug center, denver, co 3 deloitte consulting llp, atlanta, ga 4 ciber, inc. greenwood village, co abstract objectives: real-time surveillance systems are valuable for timely response to public health emergencies. it has been challenging to leverage existing surveillance systems in state and local communities, and, using a centralized architecture, add new data sources and analytical capacity. because this centralized model has proven to be difficult to maintain and enhance, the us centers for disease control and prevention (cdc) has been examining the ability to use a federated model based on secure web services architecture, with data stewardship remaining with the data provider. methods: as a case study for this approach, the american association of poison control centers and the cdc extended an existing data warehouse via a secure web service, and shared aggregate clinical effects and case counts data by geographic region and time period. to visualize these data, cdc developed a web browser-based interface, quicksilver, which leveraged the google maps api and flot, a javascript plotting library. results: two iterations of the npds web service were completed in 12 weeks. the visualization client, quicksilver, was developed in four months. discussion: this implementation of web services combined with a visualization client represents incremental positive progress in transitioning national data sources like biosense and npds to a federated data exchange model. conclusion: quicksilver effectively demonstrates how the use of secure web services in conjunction with a lightweight, rapidly deployed visualization client can easily integrate isolated data sources for biosurveillance. keywords: public health, surveillance, architecture, web services, soa using secure web services to visualize poison center data for nationwide biosurveillance: a case study 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 introduction public health surveillance is the ongoing, systematic collection, analysis, interpretation, and dissemination of data about a health-related event for use in public health action to reduce morbidity and mortality and to improve health.[1] surveillance provides the critical information necessary to support several public health functions, including outbreak detection, estimating the impact of a disease or injury, portraying the natural history of a health condition, determining the distribution and spread of illness, facilitating public health interventions, evaluating the effectiveness of those interventions, and facilitating planning.[2] historically, public health information systems supporting surveillance activities have been constructed to support specific program areas within health departments. these systems were often populated with data reported from healthcare providers, often via paper based forms, not surprisingly, leading to numerous “siloed” surveillance systems. having multiple related but disparate surveillance systems, creates many inefficiencies in the areas of analysis and communications, which become most apparent during public health emergencies. with over 3,000 state and local public health agencies, tens of thousands of other public health stakeholders (including clinical providers, laboratories, first responders, and researchers) the goal of creating an efficient, secure, and flexible centralized, nationwide biosurveillance system which meets the needs and expectations of all users becomes essentially insurmountable. today, this lack of integration presents major vulnerabilities in the healthcare system’s ability to rapidly detect and mitigate health emergencies. the goal in creating cdc’s biosense system has been to mitigate this existing vulnerability. within the biosense system, patient level data (specifically, chief complaint and diagnosis data) are transmitted securely, and subsequently stored and maintained in a centralized data warehouse. various analyses are then performed, with results being shared with biosense users as well as the original data providers. this model has proven difficult to scale, costly to maintain, and challenging for end users. it is the authors’ perspective that enhancement to the current functionality in existing biosurveillance applications (e.g., essence, rods, or biosense) with secure web services, distributed computing, grid architectures, and an open federated model for data access and exchange is one approach that could potentially correct many of their current limitations. one of the principal challenges facing existing biosurveillance implementations is their limitation in sharing data across multiple jurisdictions to support real-time surveillance activities at a national level. the ability to generate actionable health intelligence by increasing access to data and fusing multiple data streams to yield effective situational awareness is a key priority to the national biosurveillance strategy for human health.[3] efforts to move legacy biosurveillance application models from centralized and historically siloed environments to federated and distributed models of data exchange are under way in order to effectively provide timely population-wide biosurveillance coverage. federation of data enables local jurisdictional control over data procurement and stewardship while permitting secure access to approved external entities (e.g., state and federal agencies). finding new methods and technologies to augment existing biosurveillance capabilities to bridge this data exchange gap has been a focus of ongoing research at cdc in collaboration with its national and international partners. using secure web services to visualize poison center data for nationwide biosurveillance: a case study 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 methods in 2008 cdc’s national center of public health informatics (ncphi) embarked on a collaborative initiative with biosense and the american association of poison control centers (aapcc) to visualize aggregate clinical effect data based on telephone calls to the 61 poison control centers across the nation.[4,5] aapcc poison centers maintain a 24-hour poison help hotline staffed by pharmacists, physicians, and toxicology specialists that provide exposure management instructions and general poison information to patients. as part of their current workflow, all poison case information (clinical effect, demographics, medical outcomes, therapeutic interventions, etc.) is stored in the national poison data base (npds) poison surveillance database and then summarized into an annual report. prior to this initiative, poison control data was unavailable for biosurveillance visualization and analytics purposes at a national level. through the creation of a secure web service in conjunction with a lightweight, java-based visualization client known as quicksilver, cdc users were provided the tools to visualize aggregated clinical effect data both geospatially and via a time series chart. the project was able to successfully demonstrate how a federated data approach could enhance existing biosurveillance capacity by providing information access between the biosense program and the npds. creation of the quicksilver tool was a two-fold effort that involved close collaboration between the aapcc’s npds development team and the ncphi public health grid (phgrid) team. the first effort involved creation of a web service that could provide aggregate clinical effect counts from multiple geographic regions (state, zip-3, zip-5) within a single query from the npds. once this was completed, development then began on a simple object access protocol (soap) service oriented architecture (soa) client that could accept and visualize the query results returned from the npds web service. the visualization client was created in java, and is deployable to any j2ee java servlet container (i.e., is java servlet 2.0 compliant). the client was also specifically tested using the apache tomcat application server (v5.5 and v6.0). the user interface is browser-based, leveraging html and javascript, and was tested with the internet explorer, firefox, chrome, and safari web browsers. quicksilver has been successfully deployed within the cdc network, with user access controlled directly by the quicksilver business steward. a diagram outlining the relationship between the npds web service and visualization client can be seen in figure 1. using secure web services to visualize poison center data for nationwide biosurveillance: a case study 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 1. quicksilver logical deployment diagram the visualization client has a small database that stores static data such as geographic information consisting specifically of spatial polygons, centroids, and list relationships for state, zip-3, and zip-5 locations. this database is quite minimal (<100mb) and is only used for assistance with drawing shapes. no poison center data is stored at the cdc. the client uses the google maps javascript api [6] to visualize the aggregate clinical effect counts within any selected geographic region. the google maps javascript api is used, rather than the google maps kml api to prevent any poison center data from being sent to the google maps internet server. to enhance the performance of the client as a user zooms in and out of different geographic entities, use of the douglas-peucker algorithm was applied to reduce the number of onscreen points drawn, thus reducing the rendering time of map polygons. [7] because the visualization client was built upon asynchronous javascript and xml (ajax) apis that support google maps, performance under internet explorer had to be enhanced to achieve timely rendering of a selected geographic region. visualization of aggregate clinical effects data was also achieved in a time series chart using flot [8], an open source ajax api used to produce graphical plots of arbitrary datasets in real-time. a modified version of the early aberration reporting system (ears) c2 algorithm was used to detect aggregate clinical effects counts ≥ 4 standard deviations (sd) from the mean call volume using a rolling 28-day average. [9] data points which were 4 sd units above or below the mean were automatically highlighted (in red) to facilitate rapid examination. all statistical calculations were performed using java’s standard math libraries. using secure web services to visualize poison center data for nationwide biosurveillance: a case study 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 to optimize performance, the npds web service results from frequent user queries were cached in ram. this transient, in-memory cache is used to reduce the number of transactions sent to the remote web service. the cache only exists temporarily and is cleared and reset each time the application server is stopped or started. results: two iterations of the npds web service were completed in 12 weeks. the visualization client, quicksilver, was developed in four months, with client releases being reviewed by cdc and aapcc representatives on a weekly basis. when a user first enters quicksilver, they select a geographic location (state, zip-3, zip-5), date range, and clinical effect. the npds web service then returns the query results within several seconds and shows a choropleth map shaded according to clinical effects thresholds established by the user (figure 2). figure 2. choropleth map of georgia in quicksilver using secure web services to visualize poison center data for nationwide biosurveillance: a case study 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 each shaded area of the map represents a unique zip-3 or zip-5 region within the selected state. to show a time series of each respective zip-3 region within the state of georgia, the user clicks anywhere within the zip-3 or zip-5 area and a pop-up time series graph is then displayed using the flot open source charting api previously described (figure 3). figure 3. time series graph of zip-310 in georgia flot allows the user to also zoom into any date range within the time series to examine clinical effects outliers which fall outside of the empirically set statistical threshold (figure 4). using secure web services to visualize poison center data for nationwide biosurveillance: a case study 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 4. magnified time series chart showing clinical effects outlier when we used quicksilver to visualize all nausea data collected by npds in 2008 by state, over 13 significant ( >10 sd units above 28-day moving average) increases were found. discussion: the use of secure web services to enable access to previously isolated data sources for biosurveillance consumption is an emerging and appealing concept. this model aligns itself with ongoing, existing efforts within healthcare it domain such as the nationwide health information network (nhin). nhin’s vision of providing healthcare information exchanges among hospitals, laboratories, and independent healthcare providers is based upon federated data access and the use of secure web services in accordance with web services interoperability organization (ws-i) standards. the same protocols that were used to create the nhin gateway soa infrastructure were used to create the web service described in this document. it is vital using secure web services to visualize poison center data for nationwide biosurveillance: a case study 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 that biosurveillance and healthcare it infrastructures remain synchronized moving forward to ensure access and interoperability amongst web services deployed through the nhin gateway or other related entities (e.g., phgrid nodes). although this document focuses on the development of the npds web service, this model can be applied to other data sources which have the potential of providing valuable biosurveillance information. other web services are currently under development, and can be accessed through the phgrid service registry. [10] although still at an early stage of development, service registries such as this, provide a method to easily survey what data sources are available for integration into applications for detection, analysis, and visualization of public health threats. these services adhere to a common set of ws-i and w3c standards (e.g. soap, xml, schema, wsdl, ws-security) enabling heterogeneous technology platforms to communicate without developing intricate adapters to bridge different implementations. because of this adherence to standards, small teams were able to extend the functionality of a .net based web service using java based analysis and visualization techniques. as the national biosurveillance strategy continues to move forward, all public health stakeholders should continue to support enabling technologies as they provide the means to address the priority areas of the national biosurveillance strategy. ongoing informatics research should accelerate exploration of new methods to enhance how the healthcare community transforms, manipulate, and analyzes unstructured data sources. these efforts will yield actionable biosurveillance intelligence that can be used to achieve optimal situational awareness capability. aggressive financial and intellectual investments need to be made on the behalf of the healthcare community to apply these technology tools to current biosurveillance infrastructures. without these investments, the social and economic costs associated with recent disease outbreaks will likely only continue to escalate. this implementation of web services combined with a visualization client represents incremental positive progress in transitioning national data sources like biosense and npds to a federated data exchange model. it is the authors’ hope that next steps will include extending existing web services into grid-enabled web services to be then used over a secure and robust grid infrastructure. legacy biosurveillance architectures should consider this approach as it establishes a foundation for an integrated information sharing environment with minimal financial and development resource requirements. although data access services are extremely valuable, this approach also opens the door to the development of many other types of web services. viable candidates for web service development and distribution over a grid infrastructure include, but are not limited to, aberration detection, epidemiological analysis, standardized vocabularies, and visualization toolsets. future biosurveillance applications will likely require on-demand access and query capability to multiple data and analysis streams. implementing dynamic web services which can allow consumers to combine those streams however they see fit for their own biosurveillance purposes is the ultimate goal of the approach described in this document. using secure web services to visualize poison center data for nationwide biosurveillance: a case study 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 conclusion: quicksilver effectively demonstrates how the use of secure web services in conjunction with a lightweight, rapidly deployed visualization client can easily integrate isolated data sources for biosurveillance. the technologies deployed to build quicksilver provided a model to visualize npds data in a way that was not previously available to cdc nor the aapcc. [11] gridenabled web services can allow agencies like the aapcc to remain focused on their primary goals of data stewardship and the provisioning of clinical effects data through npds. agencies like cdc which depend on this data for biosurveillance and analysis purposes can then easily and quickly obtain access to this information without the responsibility of securing third party information, and thus dramatically reducing data warehousing and processing costs. overall, this project demonstrates the use of low-cost, open source, and federated technologies to create a valuable public health application that provides analysis and visualization of relevant data sources for biosurveillance consumption. acknowledgments the authors wish to thank the many collaborators on this initiative including members of the ncphi grid team. this project was supported in part by the cdc contract # 200-2006f016934. references [1] cdc. updated guidelines for evaluating public health surveillance systems: recommendations from the guidelines working group. mmwr 2001;50(no. rr-13). [2] teutsch sm, churchill re. principles and practice of public health surveillance. 2 nd ed. oxford, new york: oxford university press, 2000. [3] arthur r., bailey s., bell, b., bernhardt j., besser r., et al. national biosurveillance strategy for human health 2008-2013, version 1.0 / december 2008. available at http://sites.google.com/site/nbshh10/ accessed november 5, 2009. [4] national poison data system. available at: http://www.aapcc.org/dnn/npds/nationalpoisondatasysteminformation/tabid/311/default.aspx. accessed april 15, 2009. [5] biosense. available at: http://www.cdc.gov/biosense/. accessed april 15, 2009. [6] google maps api. available at: http://code.google.com/apis/maps/. accessed april 24, 2009 [7] douglas-peucker algorithm. available at: http://en.wikipedia.org/wiki/ramer-douglaspeucker_algorithm. accessed april 15, 2009. [8] flot. available at: http://code.google.com/p/flot/. accessed april 15, 2009. [9] yiliang z., wang w., artrubin d., wu y. initial evaluation of the early aberration reporting system --florida. mmwr supplement 2005; 54(suppl);123-130. [10] public health informatics research grid wiki, service registry. available at http://sites.google.com/site/phgrid/home/service-registry. accessed april 15, 2009. [11] american association of poison control centers. available at http://www.aapcc.org/dnn/. accessed april 15, 2009. http://sites.google.com/site/nbshh10/ http://www.aapcc.org/dnn/npds/nationalpoisondatasysteminformation/tabid/311/default.aspx http://www.cdc.gov/biosense/ http://code.google.com/apis/maps/ http://en.wikipedia.org/wiki/ramer-douglas-peucker_algorithm http://en.wikipedia.org/wiki/ramer-douglas-peucker_algorithm http://code.google.com/p/flot/ http://sites.google.com/site/phgrid/home/service-registry http://www.aapcc.org/dnn/ a three-step approach for creating successful electronic immunization record exchanges a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health janet balog 1 1 scientific technologies corporation; 4400 e. broadway blvd. ste. 705; tucson, az 85711 abstract population health and individual health are strengthened through proactive immunization programs. clinicians refer to immunization records at the point of care about to decide which vaccinations their patients and families need to reduce the risk of contracting (and spreading) vaccine preventable disease (vpd). understanding the earliest possible age intervals that are safe to administer vaccinations provides the youngest children with as much immunity as possible as early as possible. this is especially useful for children at highest risk as their visits to a medical provider may be sporadic. this, coupled with the continuous development of new and combined vaccines and complex vaccination schedules, challenges the provider to understand the appropriate vaccinations to order for their patients. under-vaccinating increases patients’ vpd risk; over-vaccinating increases provider and consumer health care costs. clinicians want to make the best clinical and economically responsible decisions — this is the challenge. the solution lies in providing clinicians timely and accurate vaccination data with decision support tools at the point of care. the use of electronic health records (ehrs) alone cannot achieve this goal. it will take an accountable team made up of the clinician organization, their ehr vendor, and a public health agency to effectively manage immunization coverage for a patient population. this paper provides a three-step approach to establish and maintain ehr data exchanges, demonstrates the value of both clinical and technical testing prior to data exchange implementation, and discusses lessons learned. it illustrates the value of federal meaningful use criteria and considers how its objective to advance data exchange with public health systems increases providers’ access to timely, accurate immunization histories and achieves desired mutual health outcomes for providers and public health programs. key words meaningful use, immunization information systems (iis), public health informatics, electronic health records (ehrs), consumer engagement, vaccine preventable disease (vpd), population health outcomes, health information technology, health information exchange, vaccines for children program (vfc), vaccine accountability, advisory committee on immunization practices (acip) http://ojphi.org/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 background in the early 1990’s the centers for disease control and prevention (cdc) established an objective for public health agencies to implement population-based data systems to capture immunization events. the goal of the data systems was to increase the vaccine coverage levels of school-aged children. the vision was straightforward: an immunization record should be available to a provider during a patient visit regardless of where that patient had received prior immunizations. in 1998, the results of a nationwide survey which assessed the development of state immunization information systems (iis) were published. the findings indicated that fifteen (15) state iiss were considered advanced for the time while the remainder of the states had little to no formal iis development efforts underway. 1 by 2009, the cdc’s immunization information system annual report (iisar) showed that nearly 85% of the sixty-four (64) state, city, and territorial iiss were receiving birth data from vital record systems. 2 in some cases these data also include the date the infant received a birth dose of hepatitis b vaccine. iis messaging, transport and security standards were established to enable data exchange between clinical systems and the iis. private providers’ early data exchanges were implemented through their practice management systems, their electronic medical record system or through 3 rd party billing applications. presently, iiss serve as a model for other electronic health record systems, given their ability to maintain secure systems and utilize practices that ensure exceedingly high data quality. because they receive data from many different sources, iiss must be able to resolve duplicate patients and vaccinations, and they do so exceedingly well. the public health expertise supporting iiss ensures their clinical credibility and their use as a clinical decision support tool. a perfect storm for immunization data exchange as of 2009, incremental steps over the previous fifteen years had slowly advanced iis development without the full commitment of the provider community. on december 30, 2009, incentives and direction for health information exchange was established through the health information technology for economic and clinical health (hitech) act. this act authorized the department of health and human services to establish programs to improve health care quality, safety, and efficiency through the promotion of health information technology (hit). funding from the american recovery and reinvestment act covered payments, commonly known as meaningful use incentives, for providers to purchase ehrs and utilize them to improve patient care outcomes. the hitech act included a provision for how providers and 1 state immunization information systems and public opinion: a case for georgia; state and local government review: vol. 30, no. 3 (fall 1998): 194-204; http://www2.gsu.edu/~padgds/streib%20immunization%20and%20public%20opinion.pdf 2 centers for disease control and prevention, 2009 immunization information system annual report; http://www2a.cdc.gov/nip/registry/iisar/iisar_query.asp http://ojphi.org/ http://www2.gsu.edu/~padgds/streib%20immunization%20and%20public%20opinion.pdf http://www2a.cdc.gov/nip/registry/iisar/iisar_query.asp a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 ehrs would engage public health agencies and systems. 3 one of the identified public health objectives involved working with the iis community. among the meaningful use stage 1 standards is a requirement to demonstrate that the provider or hospital ehr can send immunization data to an iis. the recently released meaningful use stage 2 standards include the requirement to send clinically correct and complete immunization records from the provider’s ehr to an iis. 4 future stages will expand these requirements to include bi-directional data exchange (sending data to the iis and receiving data from the iis). the cdc healthy people 2020 objectives, 5 which have been called “the nation’s roadmap for a 21 st century vaccine and immunization enterprise,” directs iiss to provide informed decisionmaking support to both consumers and health care providers. 6 national health policies that motivate communities of care and supporting technology vendors to rapidly adhere to these policies create the perfect storm for the immunization provider and public health community. after decades of collecting immunization records and supporting immunization programs, state iiss are repositories of high quality health data which can be used to significantly reduce the incidence of vaccine-preventable diseases. the challenge (for whom?) is to harness these initiatives so that data exchange between provider ehrs and iiss removes barriers to participation in the state iis, ensures that high quality immunization data is collected and exchanged between the systems, and that the data is actively used to ensure that the population is fully and appropriately immunized against vpd. the purpose of this paper is to identify steps that programs can take that will lead them toward a successful electronic immunization record exchanges between the state’s iis and the her vendor. we identify leading vendors that have a record of successful implementations and describe specific actions within a three-step implementation plan based on over 10years of observing and participating in these exchange initiatives. finally, we provide a discussion on additional considerations for state iis programs when beginning an electronic exchange initiative with a vendor or vendors. methods and approach efficient electronic data exchanges in day-to-day clinical practice are presently implemented by thousands of healthcare providers and will be common in the next few years. the accelerated pace by which states implement exchanges and support the incentive programs is illustrated by a recent unpublished survey 7 conducted by scientific technologies corporation (stc). ninety percent (90%) of states currently are currently or will soon be capable of receiving electronic 3 the office of the national coordinator for health information technology, http://healthit.hhs.gov/portal/server.pt?open=512&objid=2996&mode=2 4 medicare and medicaid programs; electronic health record incentive program – stage 2. http://www.ofr.gov/ofrupload/ofrdata/2012-21050_pi.pdf 5 healthy people 2020: immunization and infectious disease. usdhhs, washington, d.c. 2012. http://www.healthypeople.gov/2020/topicsobjectives2020/pdfs/hp2020objectives.pdf http://www.hhs.gov/nvpo/vacc_plan/ 6 healthy people 2020: immunization and infectious disease; iid-18. usdhhs, washington, d.c. 2012. http://www.healthypeople.gov/2020/topicsobjectives2020/pdfs/hp2020objectives.pdf 7 scientific technologies corporation, mollen immunization registries retail health collaboration project, state data exchanges, unpublished survey, 2012. http://ojphi.org/ http://healthit.hhs.gov/portal/server.pt?open=512&objid=2996&mode=2 http://www.ofr.gov/ofrupload/ofrdata/2012-21050_pi.pdf http://www.hhs.gov/nvpo/vacc_plan/ http://www.healthypeople.gov/2020/topicsobjectives2020/pdfs/hp2020objectives.pdf http://www.healthypeople.gov/2020/topicsobjectives2020/pdfs/hp2020objectives.pdf a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 immunization records through standard health level 7 (hl7) data exchanges. stc facilitated electronic record exchange projects with ten state iiss between 2002 and 2012. we gathered information during each of these projects on various technical, programmatic, clinical and business processes and workflow issues that can predict the likelihood of a successful data exchange implementation. we identified ehr product functionalities such as data validation processes impacting the ability to collect data meeting state iis requirements. state iis field-level requirements do vary, but a new focus on dose-level dose accountability for vaccines provided through the federal vaccine for children (vfc) program are moving them towards standardization. the steps and tasks recommended in this document involve successfully implementing data exchange between ehr vendors and an iis. we identified the steps and tasks necessary to ensure information shared between the ehr and the iis is clinically correct and complete. we also describe the steps to overcome potential barriers to a successful data exchange, lastly, we identify ways to identify ehr functional deficiencies and ways to assist the provider staff to identify changes in their business practices and workflow to compensate for those deficiencies. findings and recommendations we identified three steps to implement and operate a successful electronic information exchange system. the process begins with investigation and discovery, continues with test and evaluation, and finally concludes with the implementation itself. within each of these general steps are specific activities that must be and should be accomplished prior to moving to the next step. we describe each step and describe specific activities below. step 1: investigation and discovery the purpose of this phase is to learn as much as possible about the provider, their ehr, their ehr vendor, and their business processes before testing patient data with the iis. it is also crucial to identify primary contacts for each project stakeholder at this time. table 1 below lists ehr vendors that are market leaders and have history of successful data exchange implementations. table 1 also lists each vendor’s supported type of hl7 data exchange that meets or exceeds current requirements. http://ojphi.org/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 table 1: electronic record exchange between state immunization registries and ehr vendors type of hl7 data exchange supported ehr vendor real time export batch export supports iis queries connexin, office practicum x x nextgen ehr x mie webchart (medical informatics engineering) x x rpms (indian health service) x x (testing) netsmart technologies (insight) x x greenway medical / prime suite x allscripts professional x cerner power chart x cerner millenium x sage software (intergy) x emds x epicare (hospital and provider practices) x mccormick and mitchell x eclinical works x ehs (now success ehs) x practice partner (mckesson) x compugroup medical x ge centricity (logician) x cpsi x meditech (hospital solution) x provider activities hold an official kick-off meeting with the provider and iis team to outline the process. describe the data quality testing processes. estimate the anticipated length of time until the data exchange will go live. have the provider commit to a minimal turnaround time when responses or investigations need to be completed by the provider staff. clarify how patient confidentiality will be maintained throughout the testing process. ensure that the provider’s practice will commit leadership staff to the project through to completion. identify the technical and clinical staff accountable for testing and implementation. identify the provider’s current, past, or anticipated future participation in the vfc program. establish if there are multiple provider locations in the provider organization. identify if the practice is independent or owned by or affiliated with another entity. http://ojphi.org/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 identify where the computer server resides from which the data will be uploaded to the iis. validate the current quantity of the immunization data in the ehr: identify the length of time the practice has used the ehr. identify where the immunization legacy data resides and how or if it will be migrated to the ehr. identify where immunization data has been recorded since the ehr was launched. (ehr versus continued entry in the iis). identify provider staff who will be accountable for completing manual file uploads and how often these will be completed. identify if the provider staff is capable of generating test data from their ehr and if not who will be completing that task. explain how the data they enter into their ehr impacts their ability to track vaccine usage in the iis and their ability to order and get approval for vaccines from the state vfc program. ehr vendor activities provide the iis data specifications to the ehr vendor: identify the fields that are mandatory and recommended for the specific state iis to accept the data. establish how or if the ehr validates these data fields. identify which data fields are included in the interface. meet with the ehr vendor’s technical team to respond to their questions about the iis application, the specifications, and the data exchange testing and implementation processes. identify an ehr vendor project leader and lead technical staff assigned to the project. review the current and planned export data exchange formats, e.g., hl7 v2.3.1, hl7 v2.5.1, csv. establish the data exchange capabilities to securely send and receive data: if the ehr can receive data from the iis, determine where the data will be stored, how it will be displayed in the patient record, and the processes the ehr will use to de-duplicate both patient and vaccine records. establish what triggers data to be exported from the ehr to the iis. examples include: any change in patient data; updated demographic data only; new vaccination entry, administered or historical or the patient record has been “closed” in the ehr. understand if these triggers happen automatically or if a manual process must also occur. identify how the ehr manages iis opt out and opt in indicators in their ehr. states that require consent to allow data to be sent to the iis are opt in states. in these states, the ehr will need to indicate that consent has been signed and parse the patients included in the export by those who have consented. identify how and if the ehr supports vfc status information at the patient level (how the patient qualifies for the vfc program) and the vaccination level (the vaccine funding source). determine if the ehr documentation is fully integrated with the provider’s billing (i.e., what is documented in the ehr that determines what is generated on the patient bill). review the cvx/ cpt and mvx codes that are available in the ehr to ensure they are complete, accurate and active: http://ojphi.org/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 inactive codes may be used to document vaccinations that were given in the past (historical). ensure that the iis and the vendor have a common definition for historical and administered vaccinations. demonstration have the provider staff demonstrate how they use their ehr to input the following: patient demographic information including next of kin or legal guardian and race information. note: patient demographics may be collected in a separate module that then populates the ehr with limited demographics. historical and administered vaccinations. be sure to have the provider define what historical vaccinations mean to them. note what fields are entered as free text. review the choices available in all drop down lists and if the provider can change those values. determine if the ehr has a vaccine inventory function and if they use it. note if a vaccine funding source can be identified for administered vaccines, e.g., vfc versus private. determine if there is a vaccine forecast in the ehr. if it exists, ask how or if history of disease or contraindications impact the vaccine forecast. review what the forecast displays. identify the mandatory fields and review the data integrity checks. warning: users may be able to “trick” the ehr to bypass mandatory fields using generic placeholder information. identify where the provider documents history of disease and other contraindications to vaccination. ask if the ehr has a way to document vaccination refusals, and if so, where and how. ask if the provider knows how to generate a sample of data from their live production system. if not, who would do it for them and how. step 2: test and evaluate there are two important testing steps. the first validates the technical capability to send appropriately formatted and fully populated hl7 messages to the iis. the second ensures that patient and immunization event data is clinically accurate, correct and complete. the state iis will not implement a data exchange until both criteria have been met. technical testing this process requires an hl7 test data set to be exported from the ehr to the iis. the test file should contain at least 250 patient records to identify possible random technical transfer issues. this is usually done with mock patient records first and then live patient data. live patient data must ultimately be tested to know what the iis will ultimately get from the provider’s system. messages are reviewed to ensure the expected data set is received in the iis test environment without error. they are also reviewed for compliance with hl7 message standards and the frequency the data is populated. adherence to the hl7 message version used is also reviewed, e.g., v2.3.1 or v2.5.1. meaningful use stage 2 requires that ehrs send data in http://ojphi.org/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 v2.5.1 by 2014. 8 when progressing to testing live patient data, at least 1,000 patients with immunization messages should be reviewed. fewer messages are insufficient to identify random data quality issues that may occur. multiple iterations of test messages are usually needed to ensure that clean, accurate, and complete data will be sent to the iis when the exchange is operational. an average of three to six test exchanges is generally required. when an ehr application does not support entering valid and complete immunization and demographic data, changing the provider’s workflow and business processes may compensate for the ehr deficiencies (e.g., making a field mandatory). frequently, it is the iis rather than the ehr vendor who discovers the issues and makes recommendations to the providers for these changes. the testing process is more than a validation; it is also provider and ehr education which is ideally provided by a public health specialist as opposed to a technology expert. the public health specialist has the depth of understanding across all systems and clinical programs to make these recommendations. data quality testing some data quality testing is accomplished in the connectivity testing process described above. however, it is recommended that a more detailed process be conducted to validate the quality and quantity of immunization data captured in the provider’s ehr. the tasks include: review the accuracy of current cpt/cvx (vaccine) and mvx (manufacturer) codes in their ehr: ensure combination vaccines can be documented as some ehrs support only the entry of single vaccine antigens. combination vaccines impact vaccine forecasting so vaccines should be able to be documented in the formulation they are given. review how and where contraindications to vaccines and history of disease are documented. if they are captured, determine what codes will be sent for each value and where will they be sent in the hl7 message. ensure that discontinued codes are not being used for administered vaccines. ensure that the ehr vaccination list with the corresponding codes which will be sent in the import file is complete and correct. providers should have vaccine descriptors in their system that reflect vaccines they have available and administer as well as those that they need to document as historical vaccinations. ensure the ehr has vaccine descriptors that correspond to the correct cpt or cvx code. it is not unusual to find that the ehr upgrade has been distributed with these errors versus the provider entering them incorrectly. review the vaccination related fields to ensure that they are being consistently populated. the fields include vaccinator name, vaccine manufacturer, vaccine lot number, and vaccine expiration date. for an opt-in iis, a field to indicate that consent has been obtained must be available and populated and only consented records should import into the iis. for those providers who participate in the vfc program, an indicator must be available in the ehr to mark how the patient qualifies for vfc. this must be updated with each 8 the office of the national coordinator for health information technology, http://healthit.hhs.gov/portal/server.pt?open=512&objid=2996&mode=2 http://ojphi.org/ http://healthit.hhs.gov/portal/server.pt?open=512&objid=2996&mode=2 a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 vaccination visit. many states are now requiring this information in the hl7 message. note: vfc information is only expected in records for patients who are under age 19 years. if the vfc indicator is sent for all patients, then patients at 19 years or older should default to “ineligible.” prior to implementation, compare the hl7 messages from the provider’s ehr against what the clinician sees in their ehr: randomly select 50 or more live patient immunization messages from the group that has passed testing. have the provider pull those patient records up in their ehr and compare them; they should match exactly. have the provider identify discrepancies and review them with the vendor. one or both of the following could occur: the ehr vendor needs to correct technical errors or change the application to support staff workflow/needs. the ehr vendor needs to retrain clinical staff in the appropriate use of the ehr application so that documentation practices support the interface design. after the corrective actions have taken place, a clean test file is imported to the iis test system to demonstrate that all issues have been addressed. after the iis team accepts the test file, the provider’s ehr is ready for live data exchange. step 3: implementation phase after steps 1 and 2 are complete the provider is ready to implement data exchange between their ehr and the state iis. after the initial implementation, the data exchange processes require ongoing monitoring and evaluation. many things may change causing the import process that was originally established to fail or be interrupted. for example, with meaningful use incentive payments available, many providers are switching from one ehr to another. provider staff members change. ehr upgrades may interrupt the connection to the iis. finally, the provider’s failure to upgrade the ehr in a timely manner may cause incorrect data to be sent to the iis. the following items should be reviewed with the provider and the ehr vendor at the iis data exchange implementation: ensure the provider understands their ongoing responsibilities for the data exchange: ensure data files are sent to the iis on a regular basis: if data files are manually uploaded, determine the frequency of the data uploads as daily (preferred) or weekly (acceptable). best practice calls for two individuals within the provider’s office to understand the upload task. if data files are automatically uploaded, assign staff who will confirm that successful data file transmission occurs on a regular basis. replace assigned staff as needed when turnover occurs. establish how the cpt/cvx codes in an ehr application will be kept current. this includes adding codes as new codes are established and inactivating those that are discontinued. persons assigned this responsibility should link to the cdc listserve that automatically sends notices about changes to codes (additions, inactivation, changes). 9 vaccine codes should be 9 cdc website: mvx code list; http://www2a.cdc.gov/vaccines/iis/iisstandards/vaccines.asp?rpt=mvx cdc http://ojphi.org/ http://www2a.cdc.gov/vaccines/iis/iisstandards/vaccines.asp?rpt=mvx a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 reviewed when system upgrades occur to ensure accuracy. some providers are responsible to update their own applications and may or may not be alerted to do so by their ehr vendor. identify who will be responsible to keep ehr upgrades current. some providers will choose to lag behind when new major releases occur because they feel those releases will have more system bugs. intermittent data quality checks should be a formal process for both the iis and the provider. discuss an established schedule for these reviews and how issues will be communicated between the parties. some iiss can give the provider permissions to check the hl7 message error log themselves with appropriate iis system permission. if the ehr receiving data from the iis supports iis queries, ensure that the ehr has a process to manage duplicate patients and vaccinations. ehrs typically handle patient duplicates well because of their experience with receiving data from other systems such as labs and radiology facilities. ehrs are not usually equipped with the logic to de-duplicate vaccinations like an iis. while this is the ehr vendor’s responsibility, they will require support from the iis as they resolve their issues. discussion and recommendations meaningful use has added a level of motivation for clinical providers and hospitals to exchange data with an iis. rigorous processes to implement these links will pay dividends to public health programs and clinical providers. the state immunization program must retain the expertise and be the “source of truth” for all things immunization. they must support both ehr and provider education. this partnership must recognize that sending data to a state iis is only the first step. the power in the data will come from the ability to query the iis for patient vaccination records and accept iis generated patient age-appropriate forecasts. this will maximize the health data assets of the immunization provider community and empower clinical care physicians, nurses, and pharmacists with the complete and accurate information needed to support their vaccine administration decisions. we have identified best practices for implementing data exchange between the iis and ehr and describe these activities in detail within three main steps: identification and discovery, testing and validation, and implementation. regardless of specific circumstances, there are several important considerations regarding the implementation steps we’ve outlined in this paper. these include assumptions and preconceptions regarding the process itself, aspects of the ehr and coding, expectations on the process time and effort required, need for on-going monitoring, how to handle ehr upgrades, and others we describe in detail below. future research that would identify under what circumstances these considerations come into play will be extremely useful to reduce potential for a state’s initiative to be unsuccessful, and/or to reduce costs of implementation. first, each data exchange interface is unique. each provider or their representative has purchased and/or modified an ehr to suit their needs. each provider has been trained to use their ehr by different people and what they retain about that training varies. each provider has developed workflow processes and business practices around their ehr implementation. many providers website: cpt/cvx code list; http://www2a.cdc.gov/vaccines/iis/iisstandards/vaccines.asp?rpt=cpt http://ojphi.org/ http://www2a.cdc.gov/vaccines/iis/iisstandards/vaccines.asp?rpt=cpt a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 choose to implement their ehr in phases. experience has shown the value of using the following practices and processes: make no assumptions during any phase of the process. take the time to verify all ehr information with the vendor, the provider, and the provider’s clinical staff. the quality and quantity of data entered into the ehr is impacted by the business practices used, the workflow, staff implementation and ongoing training on the ehr application, and individual staff compliance/errors. ehrs are not a turn-key data exchange solution for an iis. because clinicians are entering immunization and other data into the ehr, providers and the iis may assume that the record of the immunization event can and will be accurate and complete. this is not the case unless the ehr has the field level validation and other functionality to require it from the user. expect the testing process to be long and challenging. less vendor attention has been paid to the ehr’s immunization module compared to other core ehr functionality mandated under meaningful use stage 1. providers may think this process will be easier than it is. explaining this fully before the process begins can help mitigate this expectation and help diffuse the perception that the iis community is the barrier to implementation. ongoing data transmission between the ehr and iis must be monitored and nurtured. routine software upgrades and hardware changes may cause an established exchange to fail. this is another common reason that continuous monitoring at the iis is important in order to spot aberrations in information flow. ehr upgrades impact immunization data quality. how and when ehr vaccination codes are updated varies by the vendor’s releases and how soon the provider chooses to implement them. after implementing the data exchange, it is important that the provider understand that their vaccine choices need to match what is being administered in their offices. keeping their systems updated in a timely manner impacts their ability to do this. ehr users are creative. they discover ways to record data in their ehr when the application does not offer them the correct vaccine choice. this applies to both doses they administer in their practice and doses that have been given elsewhere (historical doses). here are some scenarios observed during the testing phase: if the correct vaccine is not available in the ehr database, users simply select the closest choice, e.g., td, when they are actually giving tdap; or pcv7 when they are giving pcv13. this is typically due to the vendor not providing the upgrade in a timely manner or the provider opts to delay system upgrades. users documented they administered a varicella vaccine when they did not because their ehr did not offer a way to document chicken pox history in the vaccination record. ehr vaccine descriptions are frequently linked to the wrong vaccine code. iiss read the vaccine code in the hl7 message, not the vaccine description. this is discovered when reviewing the ehr vaccine and manufacturer code table review for accuracy and completeness and during the provider’s demonstration of their ehr. most ehr applications allow providers to change vaccine codes themselves by selecting from a hard-coded list. some allow an administrative user to originate new vaccine codes and descriptors in their system. http://ojphi.org/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 data fields required by the state iis for data exchange may not be mandatory or exist within the ehr. state iiss need their data to support dose level vaccine accountability for vfc vaccinations. the concept of vfc is relatively new to the ehr community. many ehrs either do not offer the fields in the ehr for the provider to complete or the data validation does not exist to make sure the fields are complete and correct. fields such as patient vfc status, vaccine funding source, vis publication date, and the date the vis was given to the patient or the parent may not exist. ehr data field validation and functionality to support complete and correct documentation of the vaccination event are sporadic. many ehrs allow free text in data fields that are required in the iis, making it highly susceptible to error. still others offer drop down lists from which to choose vaccine lot numbers but the user may be able to overwrite the field and enter free text. next of kin information is frequently not collected in the ehr. ehrs most often have responsible party, emergency contact, or guarantor (person responsible for the bill) fields which may not be the legal guardian. parent and legal guardian information is important to support de-duplication of patients in the iis: the iis may not accept these alternate fields in lieu on next of kin information. guarantor information now frequently asks for how the patient is related to the insured (natural child, step child) versus how the insured is related to the child (parent, step-parent). this makes using guarantor information in lieu of next of kin impossible. for children whose insurance is medicaid, the child’s name must be listed as the guarantor as they are the insurance holder. as such, there will never be parent or legal guardian in this field for children with medicaid coverage. clinical documentation may drive the provider’s bill. ehrs may be fully integrated with the provider’s billing. if the iis recommends changes to the ehr vaccine codes, ensure that the charges linked to that code are also reviewed before they are finalized. disrupted billing or erroneous billing puts the provider at legal and financial risk. vaccination and manufacturer codes of hospital ehr systems are generally set by the pharmacy. many hospital ehrs require extensive vaccine code mapping or “aliasing” to send data correctly. requests for additional data fields or changes to the ehr workflow are expensive and usually take many months to be completed. historical vaccinations are rarely recorded in a hospital ehr because a bona fide record to verify the information is usually not available. hospital ehr systems are not prepared to document patient or vaccination vfc information. this issue is largely unanswered in hospital ehrs. most hospitals that have worked with an iis have entered the required data directly into the iis. clinicians receive medications from the pharmacy. they are the only ones that would know if the vaccine was supplied by the vfc program. since hospitals gather the information needed to determine if a patient qualifies for vfc in other areas of the ehr, the patient vfc status could be derived. understand the provider’s organizational structure. the provider may have no direct control over the ehr in use. it is important to understand who supports the ehr in use, who has the ability to make changes in it, and where the data imported to the iis is stored. many providers are employees of larger healthcare networks and they contract for it services controlled by another entity. a single hl7 import may include data that is coming from http://ojphi.org/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 different ehr products. the data may also go through middleware that could change it before it arrives at the iis. clinical training issues will be discovered in this process. clinical vaccination errors will become evident when hl7 messages are reviewed. most provider offices are now staffed with a number of unlicensed healthcare workers who administer vaccines. these issues should be discussed with the provider’s clinical manager so that appropriate retraining can occur. this highlights the value of a robust ehr immunization module with logic to mark invalid vaccinations and forecast vaccinations based on advisory committee on immunization practices (acip) recommendations. many clinicians become dependent on this functionality available in the iis. limitations a limitation of our findings is that our recommendations are not based on a scientific approach, but rather we leveraged observations and experience gained over the course of many different projects. no project was exactly the same and we had no control over programs’ choices in many cases. another limitation is that some of our recommendations will not apply for all situations. there may be cases when a program’s implementation process may not be successful due to not be able to complete all needed activities when some do not apply. finally, we acknowledge that even if all recommendations are followed in their entirety, a program’s implementation may still not be successful due to unforeseen factors. conclusion in summary, using proven practices is key to implementing and supporting ongoing meaningful use data exchanges. immunization information system processes must be in place to monitor, alert and support the ehr and clinical care community. implementation can be achieved through following specific activities within three major steps, while keeping certain considerations regarding the process in mind. ultimately, public health-supported decisions will mark a milestone in improving healthcare outcomes, increasing individual and population protection against disease, and reducing the significant economic and health impacts — saving both dollars and lives. corresponding author janet balog, bs, rn tel: +1.520.202.3333 fax: +1.520.202.3340 email: info@stchome.com references 1. state immunization information systems and public opinion: a case for georgia; state and local government review: vol. 30, no. 3 (fall 1998): 194-204; http://www2.gsu.edu/~padgds/ streib%20immunization%20and%20public%20opinion.pdf http://ojphi.org/ mailto:info@stchome.com http://www2.gsu.edu/~padgds/ a three-step approach for creating successful electronic immunization record exchanges between clinical practice and public health online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 2. centers for disease control and prevention. 2009 immunization information system annual report; http://www2a.cdc.gov/nip/registry/iisar/iisar_query.asp 3. the office of the national coordinator for health information technology. http:// healthit.hhs.gov/portal/server.pt?open=512&objid=2996&mode=2 4. medicare and medicaid programs. electronic health record incentive program – stage 2. http://www.ofr.gov/ofrupload/ofrdata/2012-21050_pi.pdf 5. people h. 2020: immunization and infectious disease. usdhhs, washington, d.c. 2012. http://www.healthypeople.gov/2020/topicsobjectives2020/pdfs/hp2020objectives.pdf http:// www.hhs.gov/nvpo/vacc_plan/ 6. people h. 2020: immunization and infectious disease; iid-18. usdhhs, washington, d.c. 2012. http://www.healthypeople.gov/2020/topicsobjectives2020/pdfs/hp2020objectives.pdf 7. scientific technologies corporation, mollen immunization registries retail health collaboration project, state data exchanges, unpublished survey, 2012. 8. the office of the national coordinator for health information technology. http:// healthit.hhs.gov/portal/server.pt?open=512&objid=2996&mode=2 9. website cdc. mvx code list; http://www2a.cdc.gov/vaccines/iis/iisstandards/ vaccines.asp?rpt=mvx cdc 10. website: cpt/cvx code list; http://www2a.cdc.gov/vaccines/iis/iisstandards/ vaccines.asp?rpt=cpt http://ojphi.org/ http://www2a.cdc.gov/nip/registry/iisar/iisar_query.asp http://healthit.hhs.gov/portal/server.pt%ed%af%80%ed%b0%a2open%ed%af%80%ed%b0%a0%ed%af%80%ed%b0%9812%ed%af%80%ed%b0%89ob%ed%af%80%ed%b1%8di%ed%af%80%ed%b0%a7%ed%af%80%ed%b0%a0299%ed%af%80%ed%b0%99%ed%af%80%ed%b0%89mode%ed%af%80%ed%b0%a02 http://healthit.hhs.gov/portal/server.pt%ed%af%80%ed%b0%a2open%ed%af%80%ed%b0%a0%ed%af%80%ed%b0%9812%ed%af%80%ed%b0%89ob%ed%af%80%ed%b1%8di%ed%af%80%ed%b0%a7%ed%af%80%ed%b0%a0299%ed%af%80%ed%b0%99%ed%af%80%ed%b0%89mode%ed%af%80%ed%b0%a02 http://www.ofr.gov/ofr%ed%af%80%ed%b0%b8pload/ofr%ed%af%80%ed%b0%a7ata/2012-210%ed%af%80%ed%b0%980%ed%af%80%ed%b1%82pi.pdf http://www.healthypeople.gov/2020/topicsob%ed%af%80%ed%b1%8dectives2020/pdfs/%ed%af%80%ed%b0%abp2020ob%ed%af%80%ed%b1%8dectives.pdf http://www.hhs.gov/nvpo/vacc%ed%af%80%ed%b1%82plan/ http://www.hhs.gov/nvpo/vacc%ed%af%80%ed%b1%82plan/ http://www.healthypeople.gov/2020/topicsob%ed%af%80%ed%b1%8dectives2020/pdfs/%ed%af%80%ed%b0%abp2020ob%ed%af%80%ed%b1%8dectives.pdf http://healthit.hhs.gov/portal/server.pt%ed%af%80%ed%b0%a2open%ed%af%80%ed%b0%a0%ed%af%80%ed%b0%9812%ed%af%80%ed%b0%89ob%ed%af%80%ed%b1%8di%ed%af%80%ed%b0%a7%ed%af%80%ed%b0%a0299%ed%af%80%ed%b0%99%ed%af%80%ed%b0%89mode%ed%af%80%ed%b0%a02 http://healthit.hhs.gov/portal/server.pt%ed%af%80%ed%b0%a2open%ed%af%80%ed%b0%a0%ed%af%80%ed%b0%9812%ed%af%80%ed%b0%89ob%ed%af%80%ed%b1%8di%ed%af%80%ed%b0%a7%ed%af%80%ed%b0%a0299%ed%af%80%ed%b0%99%ed%af%80%ed%b0%89mode%ed%af%80%ed%b0%a02 http://www2a.cdc.gov/vaccines/iis/iisstandards/ http://www2a.cdc.gov/vaccines/iis/iisstandards/ layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a systematic evaluation of data streams for global disease surveillance alina deshpande*, mac brown, lauren castro, william b. daniel, eric n. generous, andrea hengartner, kristen margevicius and kirsten taylor-mccabe defense systems analysis division, los alamos national laboratory, los alamos, nm, usa objective the overall objective of this project is to provide a robust evaluation of data streams that can be leveraged from existing and developing national and international disease surveillance systems, to create a global disease monitoring system and provide decision makers with timely information to prepare for and mitigate the spread of disease. introduction living in a closely connected and highly mobile world presents many new mechanisms for rapid disease spread and in recent years, global disease surveillance has become a high priority. in addition, much like the contribution of non-traditional medicine to curing diseases, non-traditional data streams are being considered of value in disease surveillance. los alamos national laboratory (lanl) has been funded by the defense threat reduction agency to determine the relevance of data streams for an integrated global biosurveillance system through the use of defined metrics and methodologies. specifically, this project entails the evaluation of data streams either currently in use in surveillance systems or new data streams having the potential to enable early disease detection. an overview of this project will be presented, together with results of data stream evaluation. this project will help gain an understanding of data streams relevant to early warning/monitoring of disease outbreaks. methods three specific aims were identified to address the overall goal of determining the relevance of data streams for global disease surveillance. first, identify data streams as well as define metrics for the evaluation. second, evaluate data streams using two different methodologies, decision analysis modeling using a support tool called logical decisions® that assigns utility scores to data streams based on weighted metrics and assigned values specific to data stream categories; and a surveillance window concept developed at lanl that assigns a window or windows of time specific to a disease within which information coming from various data streams can be determined to have utility. this would obtain a ranked list of useful data streams. additionally, evaluate data integration algorithms useful for a global disease surveillance system through a review of scientific literature. finally, validate the top-ranked data streams by application of specific historical outbreaks to determine whether the data streams are capable of providing early warning or detection of the particular disease before it became a large outbreak. results seventeen categories of data streams were identified that ranged from traditional ones such as clinic/healthcare provider and laboratory records to newly emerging sources of information such as social media and internet search queries. the logical decisions® based evaluation of data streams identified 5 data streams that consistently showed utility regardless of the goal of biosurveillance. however, different data streams varied in rank, given different biosurveillance goals, and there is no one top ranked data stream. surveillance window based evaluation of data streams during disease outbreaks identified data streams that had high utility for early detection and early warning regardless of disease, while others were more disease and operations specific. additionally, we have built a searchable biosurveillance resource directory that houses information on global disease surveillance systems. conclusions lanl has developed a robust evaluation framework to determine the relevance of various traditional and non-traditional data streams in integrated global disease surveillance. through the use of defined surveillance goals, metrics and data stream categories, not only have we identified data streams currently in use that have high utility, but also new data streams that could be exploited for the early warning/monitoring of disease outbreaks. our robust evaluation framework facilitates the identification of a defensible set of options for decision makers to use to prepare for and mitigate the spread of disease. keywords evaluation; disease surveillance; data streams acknowledgments we would like to acknowledge the defense threat reduction agency (dtra)-joint science and technology office (jsto) for their support and guidance on this project. references dr. alina deshpande, dr. mac brown, ms. lauren castro, dr. william brent daniel, mr. eric nicholas generous, ms andrea hengartner, dr. kristen margevicius, dr. kirsten taylor-mccabe, los alamos national laboratory, los alamos, nm 87545. *alina deshpande e-mail: deshpande_a@lanl.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e2, 2013 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts monitoring of brucellosis in agricultural animals in ukraine during 2013-2015 oleg nevolko* state scientific research institute of laboratory diagnostics and veterinary and sanitary expertise, kyiv, ukraine objective analysis of brucellosis monitoring in agricultural animals in ukraine to control epizootic situation and prevent possible brucellosis in humans. introduction brucellosis is one of the most widespread zoonosis in the world. only 17 countries informed who that their territory is free from brucellosis. about 500 thousand cases of brucellosis in humans are registered in the world each year. the problem of brucellosis has remained actual to agriculture and health care for many years. almost all agricultural animals are highly susceptible to brucellosis. socio-economic significance of brucellosis problem is determined by peculiarities of the course of the disease and the main contingent that can be infected, namely the working population that is connected with both professional factors and social reasons. brucellosis is a chronic infectious disease. the disease in animals has the following signs: abortions and retention of secundines, orchitis, unviable litter and sterility. brucellosis is included to the list of quarantine diseases due to its social threat. methods studies of blood sera of cattle, small ruminants, horses and pigs from different ukrainian regions that were selected during the annual spring clinical examination in 2013-2015. the following serological methods were used for the studies: complement-fixation test (cft), agglutination reaction (ar), rose bengal test (rbt), prolonged complement fixation test (pcft). results currently, ukraine is free from brucellosis of animals. the last brucellosis case in pigs was registered in 2008 in odesa oblast. the last case of brucellosis in cattle in ukraine was registered in 1992. according to the ministry of health, a case of brucellosis in humans is registered in ukraine almost every year. annual serological brucellosis studies of servicing bulls, cows, heifers older than one year, horses, stud rams, ewes, boars and sows are held once a year in ukraine. during 2013-2015, the monitoring serological brucellosis studies of blood sera from cattle, small ruminants, horses and pigs from different farms in 25 oblasts of ukraine were conducted at state laboratories of veterinary medicine and state scientific and research institute of laboratory diagnostics and veterinary and sanitary expertise. table 1. serological research results in 2013, seropositive results were obtained in ar crimea – six cases in cattle, dnipropetrovsk oblast 12, kyiv oblast – 31, sumy oblast – 118, and luhansk oblast – 25 using ar and rbt techniques. in small ruminants, seropositive results were determined in luhansk oblast – 26 animals (ar). testing pigs by rbt showed the following positive results: 82 animals in dnipropetrovsk oblast, 16 in luhansk, and 1 in sumy oblast. twenty seven horses were detected positive by rbt in luhansk oblast. fig. 1. brucellosis monitoring results, 2013 in 2014, seropositive results in cattle were received in kyiv (20), dnipropetrovsk (28), sumy (66), chernihiv (37) and zhytomyr (2) oblasts using ar, rbt, and cft. ar tests were positive for one small ruminant in dnipropetrovsk and for three in sumy oblasts. five seropositive pigs were found in sumy oblast using rbt. fig. 2. brucellosis monitoring results, 2014 in 2015, seropositive results (ar, rbt, and cft) in cattle were obtained in sumy (8 animals), dnipropetrovsk (34), and chernihiv (10) oblasts. for small ruminants, one seropositive animal was found in dnipropetrovsk and three in sumy oblasts using ar. employing rbt, one pig was diagnosed in dnipropetrovsk oblast. two horses were found positive using rbt and ar in sumy oblast. fig. 3. brucellosis monitoring results, 2015 the seropositive animals were destroyed. bacteriological studies were not conducted. conclusions 1. during the studies of blood sera of agricultural animals from different ukrainian regions, positive results were obtained in 7 oblasts of ukraine indicating a possible circulation of the causative agent of brucellosis. 2. studies need the in-depth analysis that must include bacteriological testing of seropositive animals. table 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e156, 2017 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts keywords brucellosis; monitoring; serology; ukraine *oleg nevolko e-mail: olegnevolko2010@ukr.net online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e156, 2017 isds16_abstracts-final 136 isds16_abstracts-final 137 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts enabling essence to process and export meaningful use syndromic surveillance data miles stewart1, wayne loschen*1 and taha kass-hout2 1johns hopkins university applied physics laboratory, laurel, md, usa; 2public health surveillance and informatics program office, office of surveillance, epidemiology, & laboratory services, centers for disease control and prevention, atlanta, ga, usa objective the objective of this project is to enable the essence system to read in, utilize, and export out meaningful use syndromic surveillance data using the health level 7 (hl7) v2.5 standard. this presentation will detail the technical hurdles with reading a meaningful use syndromic surveillance data feed containing multiple sources, deriving a common meaning from the varying uses of the standard and writing data out to a meaningful use hl7 2.5 format that can be exported to other tools, such as biosense 2.0 (2). the presentation will also describe the technologies employed for facilitating this, such as mirth, and will discuss how other systems could utilize these tools to also support processing meaningful use syndromic surveillance data. introduction in order to utilize the new meaningful use syndromic surveillance data sets (3) that many public health departments are now receiving, modifications to their systems must be made. typically this involves enabling the storage and processing of the extra fields the new standard contains. open source software exists, such as mirth connect, to help with reading and interpreting the standard. however, issues with reliably reading data from one source to another arise when the standard itself is misunderstood. systems that process this data must understand that while the data they receive is in the hl7 v2.5 standard format, the meaning of the data fields might be different from provider to provider. additional work is necessary to sift through the similar yet disjoint fields to achieve a consistent meaning. methods this project utilized 3 separate instances of essence and biosense 2.0. for both importing and exporting hl7 v2.x standard files, the project used the open source tool mirth connect. for importing data the project adapted versions of tarrant county and cook county essence systems in the amazon govcloud to receive meaningful use syndromic surveillance data files sent from biosense 2.0. for exporting data to biosense 2.0, the project used mirth connect to poll the local version of cook county’s essence database and export the data into an hl7 v2.5 file. the resultant file was sent over secure file transfer protocol (sftp) to biosense 2.0. the team then evaluated the process by comparing the data in the local instances of essence and the corresponding instances hosted on the internet cloud. results many issues were encountered during the reading of the hl7. while the standard suggests that hospitals and hospital systems would all send data in the same fields for the same data, the reality was far different. although hl7 v2.5 is a standard and there is a defined use for each field, it can be interpreted in many ways. a large portion of time was spent communicating with the local health department to determine exactly what each field meant for a particular hospital. comparing the internet cloud and local versions did have some difficulties due to local filtration rules that eliminated non-er related records from the local tarrant county system. the project was able to utilize new query features in essence to filter down to only er related records on the internet cloud version to support the comparisons. the project was able to re-use much of the configuration that was created when moving from one jurisdiction to the other. this will help when describing how others may use the same technology in their own systems. conclusions reading and interpreting the data consistently from a data feed containing multiple sources can be challenging. confusion with the hl7 v2.3 or 2.5 standards causes many health organizations to transmit data in inconsistent ways that betrays the notion of a messaging standard. however, with the tools this project have created and the lessons we have learned, the pain of implementing meaningful use syndromic surveillance data into a system can be reduced. keywords analytics; electronic medical records for public health; interoperability; meaningful use; internet cloud acknowledgments the essence in the cloud initiative is supported by the cdc’s division of notifiable diseases and healthcare information (dndhi) biosense program. references 1) kass-hout, et al, cdc’s biosense 2.0: bringing together the science and practice of public health surveillance, ajpm prevention in practice, november 15, 2011. 2) phin messaging guide for syndromic surveillance: emergency department and urgent care data. accessed august 30, 2012: http://www.cdc.gov/ehrmeaningfuluse/syndromic.html. *wayne loschen e-mail: wayne.loschen@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e55, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts the epidemiologic vocabulary of the west and the former soviet union: different sides of the same science anna grigoryan*1, carmen clarke2, lyudmila zueva3, tetyana chumachenko4, edmond f. maes1 and bonnie smoak2 1cdc, atlanta, ga, usa; 2wrair, silver spring, md, usa; 3north-western state medical university after i.i. mechnikov, st.petersburg, russian federation; 4kharkiv national medical university, kharkiv, ukraine objective the purpose of this project was to develop an english-russian epidemiology dictionary, which is needed for improved international collaboration in public health surveillance. introduction as part of the us department of defense strategy to counter biological threats, the defense threat reduction agency’s cooperative biological engagement program is enhancing the capabilities of countries in the former soviet union (fsu) to detect, diagnose, and report endemic and epidemic, man-made or natural cases of especially dangerous pathogens. during these engagements, it was noted that western-trained and soviet-trained epidemiologists have difficulty, beyond that of simple translation, in exchanging ideas. the soviet public health system and epidemiology developed independently of that of other nations. whereas epidemiology in the west is thought of in terms of disease determinants in populations and relies on statistics to make inferences, classical soviet epidemiology is founded on a more ecological view with the main focus on infectious diseases’ spread theory. consequently many fundamental soviet terms and concepts lack simple correlates in english and other languages outside the soviet sphere; the same is true when attempting to translate from english to russian and other languages of the fsu. systematic review of the differences in fsu and western epidemiologic concepts and terminology is therefore needed for strengthening understanding and collaboration in disease surveillance, pandemic preparedness, response to biological terrorism, etc. methods following an extensive search of the russian and english literature by a working group of western and fsu epidemiologists, we created a matrix containing english and russian definitions of key epidemiologic terms found in fsu and western epidemiology manuals and dictionaries, such as a dictionary of epidemiology (1), epidemiology manual (2) and many other sources. particular emphasis was placed on terms relating to infectious disease surveillance, analysis of surveillance data, and outbreak investigation. in order to compare the definitions of each term and to elucidate differences in usage and existing gaps, all definitions were translated into english and russian so that the definitions could be compared side by side and discussed by the working group. results six hundred and thirty one terms from 27 english and 51 russian sources were chosen for inclusion based on their importance in applied epidemiology in either the west or the fsu. review of the definitions showed that many terms within biosurveillance and infectious disease public health practice are used differently, and some concepts are lacking altogether in the russian or english literature. significant gaps in fsu epidemiology are in the areas of biostatistics and epidemiologic study designs. there are distinctive differences in fsu and western epidemiology in the conceptualization and classification of disease transmission, surveillance practices, and control measures. conclusions epidemiologic concepts and definitions significantly differed in the fsu and western literature. to improve biosurveillance and international collaboration, recognition of these differences must occur. detailed analysis of epidemiology terminology differences will be discussed in the presentation and paper. major limitations of the work were scarcity of prior research on the subject and lack of bilingual epidemiologists with the good understanding of fsu and western approaches. a bilingual reference in the form of a dictionary will greatly improve mutual comprehension and collaboration in the areas of biosurveillance and public health practice. keywords surveillance; dictionary; collaboration references 1. porta miquel. a dictionary of epidemiology, fifth edition, oxford university press, usa, 2008 2. zueva l.p.yafaev p.kh. epidemiology: manual. “foliant publishers”, russia, 2005. *anna grigoryan e-mail: ffg7@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e45, 2013 public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi public health quality improvement exchange: a tool to support advancements in public health practice stephen l. brown1*, barbara l. massoudi1, jamie m. pina1, kusuma madamala2 1. public health informatics program, rti international, research triangle park, nc, united states 2. public health system consultant, portland, or, united states abstract objectives: the public health quality improvement exchange (phqix) is a free, openly available online community that supports public health practitioners in the rapidly evolving landscape of public health quality improvement (qi). this article’s objective is to describe the user-centered development of phqix and its current content and examine how elements of a qi initiative may vary by an organization’s characteristics or qi experience. methods: phqix was developed by taking a user-centered iterative design approach, seeking early and continued input from users to gather requirements for the website. we performed an exploratory analysis of the published qi initiative descriptions, reviewing all qi projects that phqix users shared as of january 1, 2018. results: phqix features 193 qi initiatives from a variety of health departments and public health institutes using a wide range of qi methods and tools. discussion: submitted qi initiatives focus on many public health domains and favor the pdca/pdsa cycle; kaizen; and fishbone diagrams, flowcharts, process maps, and survey methods. limitations include data coming only from users who represent health departments with sufficient time to complete the phqix submission template. additionally, many initiatives were submitted in part to fulfill a grant requirement, which could skew results. conclusion: as the field of qi in public health practice evolves, resources targeted to qi practitioners should build on and advance the available resources. findings from this study will provide insight into qi initiatives being performed and the types of projects that can be expected as organizational experience and collaboration grow. keywords: informatics, public health, public health accreditation, quality improvement, science of improvement abbreviations: plan, do, check/study, act (pdca/pdsa); public health quality improvement exchange (phqix); quality improvement (qi); expert panel (ep); user group (ug) correspondence: stephenbrown@rti.org* doi: 10.5210/ojphi.v10i3.9566 copyright ©2018 the author(s) mailto:stephenbrown@rti.org* public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi introduction quality improvement (qi) has become an increasingly important activity for health departments as they seek to efficiently improve the health of populations they serve. public health departments are implementing qi initiatives rapidly, given these initiatives’ potential to streamline processes, reduce costs, improve health outcomes for populations, and implement a culture of quality in organizations [1-3]. health departments are also moving toward qi to document capacity and performance standards as part of the process of accrediting their organizations [4]. the public health quality improvement exchange (phqix) is a free, openly available online community that supports public health practitioners in the rapidly evolving landscape of qi in public health [5]. supported by the robert wood johnson foundation, this effort has published 193 in-depth descriptions of real-world qi initiatives on its website since it launched in october 2012. phqix is unique among resources for public health practitioners because of its exclusive focus on qi in public health, qi project documentation, its community features, and its integrated search capacity that allows users to find examples of recent qi work from other health departments around the country [6]. the primary resource on the phqix website is the set of initiative descriptions that present detailed data in a structured format. the descriptions may also include attachments such as diagrams, qi tools and process templates, surveys, policies, and storyboards. users can browse and search these descriptions through free-text search or by using a set of faceted terms based on a public health qi taxonomy developed specifically for the website. for example, users can search for projects in a variety of topical categories such as immunizations, laboratory services, maternal and child health, environmental health, and administrative areas. although the qi initiative descriptions are not intended to represent best practices, they help practitioners learn from previous work performed at other health departments and allow them to adopt or adapt elements of the initiatives for their own purposes. users frequently seek out initiatives that would be practical to implement at their own health departments and are interested in using products of these initiatives (e.g., storyboards, surveys) to increase qi capacity and accreditation readiness at their institutions [7]. the aim of this study is to describe the user-centered development of the tool and its current content and to examine how elements of a qi initiative may vary by an organization’s characteristics or qi experience. the content descriptions include an initiative’s methods (e.g., lean/six sigma, kaizen), tools (e.g., surveys, process maps), and focus activities (e.g., immunizations, data collection, administrative activities). this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi methods phqix was developed by taking a user-centered iterative design approach [8-11], which sought early and continued input from users to gather requirements for the website, test early prototypes, and participate in an evaluation of the site [7]. early in the project, we formed two sets of experts to guide the design and development of the system. those working in qi in public health became members of our user group (ug), and national-level experts in qi became members of the expert panel (ep). the ug and the ep participated in focus groups; from these groups, we developed storyboards to reflect requirements and design elements for the system. the storyboards were vetted through the ep and were used to guide the development of the initial prototypes, which were tested by stakeholders at public health conferences. these stakeholders were selected because they represented the intended users of the system, and they were identified through the ep. feedback about the usability of the prototypes was sought using the think-aloud process while stakeholders interacted with the prototype by working through real-life scenarios. this feedback was then incorporated into the next prototype version, which was then tested with users again. a final iteration of the prototype was produced and launched in october 2012 at the american public health association annual meeting and expo. after the rollout of the first operational system in 2012, limited development occurred over the next 2 years, and in 2014, the system went into operations and maintenance mode. community supporting features that were added during those 2 years included a map of submitters’ locations; qi spotlight articles, featuring aspects of qi work in public health; video highlights of exemplary projects; ask an expert q&a; the community forum threaded discussion list and associated incentives for participation; the monthly newsletter detailing information about the community and the project; and the weekly digest, providing quick snapshots of information about qi happenings. our exploration of the published qi initiative descriptions consisted of a review of all 193 public health qi projects and the organizational characteristics that registered phqix users shared, as of january 1, 2018, approximately 5 years after the website’s initial launch. the users who submitted the qi initiative data were employees of state, local, and tribal health departments who had participated in a public health qi activity. submissions are subject to a review process by the ep, composed of qi subject matter experts. upon receiving new submissions, the site’s submission coordinator confirms that all appropriate data fields are properly completed, then distributes the initiative to an expert panel member for review. the panel member then assesses the relevance of the submission as a true qi initiative and determines whether sufficient documentation is provided. finally, the panel member works directly with the initiative’s submitter to make any necessary clarifications or additions. all accepted submissions are then published on the website and have been included in this study population. the unit of analysis for this study is the qi initiative or project. we conducted an exploratory analysis of the data fields across the qi initiatives, examining what implications an organization’s characteristics have for the type of initiative it will conduct. we sought to determine whether health departments of a particular size, type, or experience with qi would affect the likelihood of them using specific tools or methods or selecting a specific area of services for improvement. the exploration of the initiatives included information about the health department and the population it serves, tools and methods used, project duration, types of partner public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi organizations with which the health department collaborated, and the health department’s level of qi activity. for any qi initiative, it is possible to have used multiple methods, tools, or focus areas. we used the chi-squared test to confirm all statistically significant associations among variables. this paper reports descriptive statistics of these self-assigned attributes and the results of multivariate analyses among qi methods, tools, and health department qi activity level. results the phqix website features 193 qi initiatives from 38 states (figure 1), which included 159 submissions from local health departments, 28 from state health departments, 2 from tribal health departments, and 4 from public health institutes. washington state and north carolina have produced the most published submissions, with 16 initiatives each. oregon (13), wisconsin (13), illinois (12), and michigan (11) all also published more than 10 submissions. the midwest and pacific northwest regions have had more phqix submission activity than other regions, whereas 12 states have not published qi initiatives on phqix. the self-reported organizational qi activity level at the submitting organization varies in an ordinal range including formal qi in specific areas (39.9%), informal qi (21.2%), formal agency-wide qi (20.7%), qi culture (11.9%), and qi community (3.6%) [12]. the organizations serve populations ranging from fewer than 24,499 people (5.2%) to more than 1 million (17.1%). the most common population groups are 100,000 to 249,999 (23.3%), more than 1 million (17.1%), and 250,000 to 499,999 (16.2%). the most common submitting organization type is county health department (45.6%), followed by state health department (14.5%), city-county health department (7.8%), and multi-county health department (6.7%). public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi figure 1: published phqix qi initiatives, by state: 2012–2017 the data show that submissions come from a wide variety of public health departments, with smaller health departments submitting fewer initiatives (26.9%), and health departments serving more than 100,000 people submitting more initiatives (73.1%). health departments with a qi activity level of at least “formal qi in specific areas” submitted the majority (76.2%) of published initiatives, whereas health departments with “informal qi” submitted only 23.8% of the total number. table 1 shows that although the plan, do, check/study, act (pdca/pdsa) cycle is the most commonly used qi method or approach (88.1%), health departments also use kaizen (19.2%), rapid-cycle improvement (17.1%), lean/six sigma (13.5%), and model for improvement (13.0%). the most frequently used qi tools reported in table 2 were brainstorming (67.9%), fishbone diagrams (54.4%), process maps (47.2%), flowcharts (45.6%), surveys (42.5%), root cause analyses (39.4%), and the 5-whys (32.6%). the most commonly reported partner organizations of the leading organization conducting the qi initiatives were local health departments (20.7%), state health departments (16.1%), community-based organizations (9.9%), and universities (6.2%). qi methods and tools do not vary widely by population served, type of health department, or level of qi activity. pdca/pdsa methods are used widely across all organization characteristics, but health departments serving larger populations use the kaizen method more (30.9% for populations greater than 500,000) compared with those serving smaller populations (12.7% for populations fewer than 500,000) (p=.005). health departments for larger populations are also slightly more public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi likely to use lean/six sigma (17.6% for populations greater than 250,000) than those for smaller populations (8.3% for populations fewer than 250,000). the same is true for rapid-cycle improvement (21.2% for populations greater than 250,000 and 14.6% for populations fewer than 250,000), although these observations did not achieve statistical significance. table 1: qi methods/approaches for published qi initiatives (n=193)* qi method/approach number of initiatives percentage plan, do, check/study, act cycle 170 88.1% kaizen 37 19.2% rapid-cycle improvement 33 17.1% lean/six sigma 26 13.5% model for improvement 25 13.0% nominal group technique 5 2.6% business process analysis 4 2.1% adaptive promising practice 1 0.5% standardize, do, check, act cycle 1 0.5% total quality management 1 0.5% *the methods/approaches listed in this table are not mutually exclusive; therefore, the sum of percentages exceeds 100.0%. public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi table 2: qi tools for published qi initiatives (n=193)* qi tool number of initiatives percentage brainstorming 131 67.9% fishbone diagram 105 54.4% process map 91 47.2% flowchart 88 45.6% survey 82 42.5% root cause analysis 76 39.4% 5-whys 63 32.6% cause-and-effect diagram 56 29.0% prioritization matrix 49 25.4% affinity diagram 45 23.3% pareto chart 22 11.4% run chart 21 10.9% multi-voting technique 17 8.8% check sheet 14 7.3% force-field analysis 13 6.7% histogram 8 4.1% strengths-weaknesses-opportunities-threats analysis 8 4.1% control chart 7 3.6% interrelationship digraph 6 3.1% radar chart 6 3.1% control and influence plot 5 3.6% tree diagram 4 2.1% process decision program chart 3 1.6% specific, measurable, achievable, realistic, timely (smart) chart 3 1.6% *the tools listed in this table are not mutually exclusive; therefore, the sum of percentages exceeds 100.0%. health departments submitting to phqix also indicate the types of organizations they partnered with during their qi initiative. although the most common partner organization types are not public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi significantly affected by submitting organization type or organizational qi activity level, state health departments are more likely to have a partner organization for their qi initiative. state health departments partner with local health departments (p=.02), other state health departments (p=.002), and community-based organizations (p=.001) in 36%, 36%, and 39% of initiatives, respectively. meanwhile, local health departments partner with the same organization types at rates of 16%, 12%, and 5%, respectively. table 3 shows the most common focus areas for published initiatives: policies/internal procedures and processes, qi and accreditation readiness, organizational effectiveness, and customer service/satisfaction, all in the administration category. in addition, the data indicate that organizations with a higher organizational qi activity level reported with higher frequency that they perform initiatives focused on policies/internal procedures and processes and qi and accreditation readiness. table 3: most common focus activities for qi initiatives submitted by health departments (n=193) focus activity number of initiatives percentage policies/internal procedures and processes 40 20.7% organizational effectiveness 37 19.2% qi and accreditation readiness 34 17.6% customer service/satisfaction 32 16.6% access to care 25 13.0% data collection and management/information technology 22 11.4% environmental health 22 11.4% communications 20 10.4% women, infants, and children programs 16 8.3% workforce development 16 8.3% communicable/infectious diseases 15 7.8% prenatal care 14 7.3% capacity development 14 7.3% performance management 13 6.7% childhood immunizations: administration of vaccine to population 12 6.2% maternal and child health (data collection, epidemiology, and surveillance) 12 6.2% reportable diseases 10 5.2% public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi collaboration/resource sharing 10 5.2% maternal and child health home visits 9 4.7% food safety education 9 4.7% financial management 8 4.1% tobacco 8 4.1% as shown in figure 2, the number of qi initiatives an organization reports performing per year appears to be associated with that organization’s self-reported organizational qi activity level. figure 2 illustrates that of the organizations reporting informal qi, 83% perform only one to three initiatives per year, whereas only 29% of those reporting a qi community perform the same number of initiatives. additionally, 0% of organizations reporting informal qi perform 7 to 10 initiatives per year, whereas 43% of those reporting a qi culture do so. similarly, the percentage of organizations that perform 11 to 20 initiatives annually rises from 0% to 13% for the same groups. the informal qi organization set is also the only one with health departments that perform no qi initiatives per year (10%). organizations with less formal qi undertook fewer qi initiatives in a given year. the most common duration of qi initiatives submitted to phqix, measured from start to finish, is 6–12 months (52.8%), followed by less than 6 months (21.2%) and 12–18 months (7.8%). figure 2: annual number of qi initiatives, by organizational qi level: 2012–2017 public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi discussion the phqix website and community were designed and developed with engagement of a broad group of public health and qi stakeholders. this ensured that the website would meet the needs of the intended user audience, which is largely composed of local and state public health departments and institutes. in examining those that submitted qi projects to phqix, we found that local health departments are much more likely to submit initiatives than state health departments. this is probably because of the significantly higher proportionate number of existing local health departments and because of increased interaction with phqix from local health departments that received qi grants from the robert wood johnson foundation. a higher percentage of submissions were received from staff at health departments working to formalize qi at their health department, which may be the result of increased efforts to perform and document qi work as they strive for accreditation. conversely, health departments with informal qi perform fewer qi initiatives and may be less inclined to share their work, feeling that it may not meet the standards of qi performed by health departments with more formalized qi. state health departments showed a higher likelihood of collaboration with a partner, which may be caused by many factors, including assisting local health departments, a larger project scope, or more initiative stakeholders. the submitted qi initiatives focus on many different public health domains and favor the pdca/pdsa cycle; kaizen; brainstorming; and using fishbone diagrams, flowcharts, process maps, and survey methods. supporting similar national findings of local and state health departments, the pdca/pdsa cycle remains the predominant choice for qi method [13,14]. (insert citations of astho and naccho profile data) more recent submissions indicate growing use of the kaizen method (particularly for organizations that serve larger populations), and future research should monitor this trend. health departments serving larger populations may be more likely to use such methods as kaizen and lean/six sigma, perhaps because they have funds budgeted for trainings or seek grants featuring such methods. although no significant relationships are evident among health departments’ type, capacity, or the methods and tools employed, an organization’s reported qi activity level may have an association with the number of qi initiatives it performs annually and the duration and focus of those initiatives. health departments seeking to formalize qi will continue to increase the number of initiatives performed annually. . conclusion as the field of qi in public health practice evolves, resources targeted to qi practitioners should build on and advance the available resources. the increasing number of health departments across the country seeking accreditation will continue to fuel interest in qi information and trainings. as more health departments are likely to increase the formalization of qi at their organizations, future research should continue to monitor the trends of initiatives from organizations with a growing qi culture. understanding the trajectory of the field of qi in public health is important for practitioners and researchers alike. findings from this study will provide insight into qi initiatives being performed and the types of projects that can be expected as organizational experience and collaboration grow. as previous studies used qi initiative data to establish a framework to define and assess the impact of qi [15] and to determine which characteristics of qi projects affect whether a given project will achieve its stated goals [16], collecting measures of efficiency or effectiveness could help to expand the usefulness of the database. public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi phqix is now being transitioned to the public health accreditation board [17], which will become the host of the resource. limitations this study had several limitations: the first is that the data come only from users who represent health departments that could dedicate the time to complete the phqix submission template, along with making any necessary revisions. as a result, the phqix database represents a snapshot of qi activities in public health, and it is unknown whether that snapshot is representative of the universe of public health qi projects. many of the initiatives described were submitted in part to fulfill a grant requirement, which could skew the data if only specific types of health departments were eligible for this grant funding or if such grants focused on implementing a specific qi method or tool. additionally, although a panel of qi experts review the submissions, the accuracy of some of the collected data fields is reliant on the submitter’s understanding of the various options (e.g., health department’s organizational qi activity level) and are therefore subject to errors of selfreport. finally, although the database of qi initiatives featured on phqix is substantial, it may not be large enough to infer statistical significance in all observed trends and associations where true differences exist. acknowledgements we would like to acknowledge the support of the phqix user group, expert panel, and all website users for their contributions to phqix since its inception in 2012. financial disclosure this work was supported by a contract from the robert wood johnson foundation to rti international (#716472). competing interests no competing interests references 1. riley wj, moran jw, corso lc, beitsch lm, bailek r, et al. 2010. defining quality improvement in public health. j public health manag pract. 16(1), 5-7. https://doi.org/10.1097/phh.0b013e3181bedb49 pubmed 2. livingood wc, sabbagh r, spitzfaden s, hicks a, wells l, et al. 2013. a quality improvement evaluation case study: impact on public health outcomes and agency culture. am j prev med. 44(5), 445-52. https://doi.org/10.1016/j.amepre.2013.01.011 pubmed 3. livingood wc, peden ah, shah gh, marshall na, gonzalez km, et al. 2015. comparison of practice based research network based quality improvement technical assistance and https://doi.org/10.1097/phh.0b013e3181bedb49 https://doi.org/10.1097/phh.0b013e3181bedb49 https://doi.org/10.1016/j.amepre.2013.01.011 https://doi.org/10.1016/j.amepre.2013.01.011 public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi evaluation to other ongoing quality improvement efforts for changes in agency culture. bmc health serv res. 15, 300. https://doi.org/10.1186/s12913-015-0956-3 pubmed 4. riley wj, bender k, lownik e. 2012. public health department accreditation implementation: transforming public health department performance. am j public health. 102(2), 237-42. https://doi.org/10.2105/ajph.2011.300375 pubmed 5. the public health quality improvement practice exchange. 2018 [cited 2018 nov 16]; available at: http://www.phqix.org/ 6. pina j, massoudi bl, chester k, koyanagi m. 2018. synonym-based word frequency analysis to support the development and presentation of a public health quality improvement taxonomy. j public health mgmt pract. epub ahead of print. doi: 10.1097/phh.0000000000000805. 7. porterfield ds, marcial lh, brown s, throop c, pina j. 2017. evaluation of a quality improvement resource for public health practitioners: the public health quality improvement practice exchange. pub hlth reports. 132(2), 140-48. https://doi.org/10.1177/0033354916689609 8. bernard hr. handbook of methods in cultural anthropology. lanham, md: altamira press; 1998. 9. muller mj. participatory design: the third space in hci. in: jacko ja, sears a, editors. the human-computer interaction handbook: fundamentals, evolving technologies and emerging applications. mahwah, nj: lawrence erlbaum associates; 2003. 10. pilemalm s, timpka t. 2008. third generation participatory design in health informatics— making user participation applicable to large-scale information system projects. j biomed inform. 41(2), 327-39. https://doi.org/10.1016/j.jbi.2007.09.004 pubmed 11. stanton na, salmon pm, rafferty la, walker gh, baber c, et al. human factors methods: a practical guide for engineering and design. 2nd ed. burlington, vt: ashgate publishing company; 2013. 12. the phases of a culture of quality. 2018 [cited 2018 nov 16]; available at: http://qiroadmap.org/the-phases-of-a-culture-of-quality/ 13. association of state and territorial health officials. astho profile of state and territorial public health: volume 4. 2017 [cited 2018 nov 20]; available at: http://www.astho.org/profile/volume-four/2016-astho-profile-of-state-and-territorialpublic-health/ 14. national association of county & city health officials. 2016 national profile of local health departments. 2017 [cited 2018 nov 20]; available at: http://nacchoprofilestudy.org/wpcontent/uploads/2017/10/profilereport_aug2017_final.pdf https://doi.org/10.1186/s12913-015-0956-3 https://doi.org/10.1186/s12913-015-0956-3 https://doi.org/10.2105/ajph.2011.300375 https://doi.org/10.2105/ajph.2011.300375 https://doi.org/10.1177/0033354916689609 https://doi.org/10.1016/j.jbi.2007.09.004 https://doi.org/10.1016/j.jbi.2007.09.004 public health quality improvement exchange: a tool to support advancements in public health practice online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(3):e223, 2018 ojphi 15. mclees aw, nawaz s, thomas c, young a. 2015. defining and assessing quality improvement outcomes: a framework for public health. am j public health. 105(suppl 2), s167-73. https://doi.org/10.2105/ajph.2014.302533 pubmed 16. beitsch lm, carretta h, mckeever j, pattnaik a, gillen s. 2013. the quantitative story behind the quality improvement storyboards: a synthesis of quality improvement projects conducted by the multi-state learning collaborative. j public health manag pract. 19(4), 330-40. https://doi.org/10.1097/phh.0b013e3182629054 pubmed 17. the public health accreditation board (phab). 2018 [cited 2018 nov 16]; available at: http://www.phaboard.org/ https://doi.org/10.2105/ajph.2014.302533 https://doi.org/10.2105/ajph.2014.302533 https://doi.org/10.1097/phh.0b013e3182629054 https://doi.org/10.1097/phh.0b013e3182629054 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts surveillance of heat-related morbidity: relation to heatrelated excess mortality robert mathes*1, kristina b. metzger2, kazuhiko ito1 and thomas matte1 1new york city department of health and mental hygiene, queens, ny, usa; 2city of austin/travis county health and human services department, austin, tx, usa objective to describe the extent to which heat-illness indicators increase with extreme heat and to evaluate the association among daily weather, heat-related illness and natural cause mortality. introduction the impact of heat on mortality is well documented [1-3] but deaths tend to lag extreme heat and mortality data is generally not available for timely surveillance during heat waves. recently, systems for near-real time surveillance of heat illness have been reported [4] but have not been validated as predictors of heat related mortality. in this study, we examined the associations among weather, indicators of heat-related ambulance calls and emergency department visits and excess natural cause mortality in new york city (nyc). methods we analyzed daily weather conditions, emergency medical system (ems) calls flagged as heat-related by ems dispatchers, emergency department (ed) visits classified as heat-related based on chief complaint text, and natural cause deaths. ems and ed data were obtained from data reported daily to the city health department for syndromic surveillance. we fit generalized linear models to assess the relationships of daily counts of heat related ems and ed visits to natural cause deaths after adjustment for weather conditions during the months of may-september between 1999 and 2008. results we observed an increase in mean total calls to ems and a decrease in mean total visits to eds during 10 observed heat waves (maximum heat index ! 90° f (fahrenheit) for four or more consecutive days with the first three days ! 95° f and at least one day !100°f) in nyc between 1999 and 2008. both ems and eds experienced an increase in heat-related incidents during heat waves though the increase in heat-related ems calls was much greater. a modest increase in mean natural cause deaths was also observed. controlling for temporal trends, an 11% (95% confidence interval (ci): 5-18) and 7% (95% ci: 4-9) increase in natural cause mortality was associated with an increase from the 50th percentile to 99th percentile of same-day and one-day lagged heat-related ems calls and ed visits, respectively. after controlling for both temporal trends and weather, we observed a 10% (95% ci: 4-16) increase in natural cause mortality associated with one-day lagged heat-related ems calls and a 5% mortality increase with one-day lagged ed visits (95% ci: 2-8). conclusions heat-related ems calls and ed visits lagged one day predicted natural cause mortality in our temporal and weather-adjusted model. in particular, risk of mortality rapidly increased as the number of heatrelated ems calls approached high levels (>100 heat-related calls/day). heat-related illness can be tracked during heat waves using ems and ed data which are indicators of heat associated excess natural cause mortality during the warm weather season. keywords surveillance; heat; morbidity; mortality acknowledgments this research was funded by the environmental protection agency, star grant r833623010, and in conjunction with the alfred p. sloan foundation, grant 2010-12-14. we thank the members of the new york city department of health and mental hygiene syndromic surveillance unit. references 1. curriero, f.c., et al., temperature and mortality in 11 cities of the eastern united states. am j epidemiol, 2002. 155(1): p. 80-7. 2. dolney, t.j. and s.c. sheridan, the relationship between extreme heat and ambulance response calls for the city of toronto, ontario, canada. environ res, 2006. 101(1): p. 94-103. 3. knowlton, k., et al., the 2006 california heat wave: impacts on hospitalizations and emergency department visits. environ health perspect, 2009. 117(1): p. 61-7. 4. chau, p.h., k.c. chan, and j. woo, hot weather warning might help to reduce elderly mortality in hong kong. int j biometeorol, 2009. 53(5): p. 461-8. *robert mathes e-mail: rmathes@health.nyc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e156, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts hiv surveillance in india: an overview & implications for future divya persai* public health fiooundation of india, delhi, india objective to study and analyze the surveillance activities in hiv prevention and control in india. introduction surveillance of risky behaviors of hiv infection and its manifest diseases has provided a better understanding of the complex nature of the hiv epidemic in india. however, little attempt is made to analyze progress of these surveillance activities. methods a review & analysis of surveillance activities undertaken in india were done. pub-med, cohrane library and peer-reviewed journals were referred for relevant literature. results initially, medical officers from multiple types of government hospitals in india were expected to report aids cases, including deaths. however, this reporting mechanism was inadequate, complicated by many disparate types of reporting units with incomplete and delayed reports. therefore aids case reporting has been replaced by hiv case reporting from the 4532 integrated counseling and testing centers. newer surveillance strategies like behavior sentinel surveillance measure behaviors that affect risk for acquiring hiv. however, behavioral and biological data are resource-intensive and time-consuming. facility-based sero-surveillance (also called hiv sentinel surveillance or hss) has emerged as the key surveillance strategy for hiv/aids in india. starting with 55 urban sentinel sites hiv sentinel surveillance expanded to 1215 in 1994. most of these pre-selected sites were antenatal clinics but also included sexually transmitted infection clinics and special facilities. subsequent expansion of high-risk group sites has improved the representation of all sub-populations in hss. while stigma against most high-risk populations and hiv-positive people continues, it has lessened as shown by the behavioral surveys. also, accessibility to testing sites has increased with increased availability of care and treatment options for infected individuals. conclusions while acknowledging the vastness and diversity of india, the key limitations remain suboptimal coverage and lack of representativeness surveillance data. moreover, due to selection bias, the populations selected for hss at targeted intervention sites may not represent everyone in that community. there is lack of national information system to collect hiv testing information from the private sector. further efforts are needed to improve hiv surveillance data and usage of this data to predict the epidemic. keywords surveillance; hiv; india references 1. department of aids control, ministry of health and family welfare, national aids control organization (naco) annual report, 20092010. www.nacoonline.org/ 2. national family health survey, india: http://www.nfhsindia.org/ 3. who case definitions of hiv for surveillance and revised clinical staging and immunological classification of hiv-related disease in adults and children; isbn: 978 92 4 159562 9. august 2006. 4. family health international (fhi) website: fhi-conducted bss and ibbss reports 1989-2009. www.fhi.org/en/hivaids/pub/survreports/index.htm 5. bachani d, sogarwal r, rao ks. a population bases survey on hiv prevalence in nagaland, india. saarc j tuber lung dis hiv/aids 2009 (1)1-11. 6. the world health organization’s global strategy for prevention and assessment of hiv drug resistance; diane e bennett, s bertagnolio, d sutherland, c f gilks: antiviral therapy 13 suppl 2:1-13; 2008 international medical press:1359-6535. 7. technical consultation to review hiv surveillance in india, 23-25 april 2008, new delhi, india. who/sear and naco. sea/aids/182. available at www.searo.int/hiv-aids publications. 8. hiv/aids epidemic in india: risk factors, risk behavior & strategies for prevention & control; godbole s, mehendale s: indian j med res 121, april 2005(356-368). 9. stigma in the hiv/aids epidemic: a review of the literature and recommendations for the way forward; mahajan a p, sayles jn, patel va, remien rh, ortiz d, szekeres g, coates tj. aids 2008 august; 22(suppl 2): s67-s79. 10. epidemiological analysis of the quality of hiv sero-surveillance in the world: how well do we track the epidemic?: walker n, garciacalleja jm, asamoah-odei e, poumerol g, lazzari s, ghys pd, scwartlander b, stanecki ka. aids 2001 aug 17; 15(12):1545-54. 11. advances and future directions in hiv surveillance in lowand middle-income countries. diaz t, garcia-calleja jm, ghys pd, sabin k. curr opin hiv aids. 2009 jul;4 (4):253-9. *divya persai e-mail: dpersai@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e173, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts enhanced disease surveillance during the 2012 republican national convention, tampa, fl david atrubin*, michael wiese, rebecca snider, kiley workman and warren mcdougle hillsborough county health department, tampa, fl, usa objective to describe disease and illness surveillance utilized during the 2012 republican national convention (rnc) held august 26-30, 2012 in tampa, fl. introduction while the tampa bay area has previously hosted other high profile events that required heightened disease surveillance (e.g., two super bowls), the 2012 rnc marked the first national special security event (nsse) held in florida. the hillsborough county health department (hchd), in conjunction with the pinellas county health department (pinchd) coordinated disease surveillance activities during this time frame. this presentation will focus of the disease surveillance efforts of the hillsborough county health department during the 2012 rnc. in addition to the surveillance systems that are used routinely, the hchd epidemiology program implemented additional systems designed to rapidly detect individual cases and outbreaks of public health importance. the short duration of rnc, coupled with the large number of visitors to our area, provided additional surveillance challenges. tropical storm isaac, which threatened tampa in the days leading up to rnc, and an overwhelming law enforcement presence likely dissuaded many protestors from coming to tampa. as a result, a tiny fraction of the number of protestors that were expected actually showed up. methods our normal daily analysis of the emergency department (ed) data using the electronic surveillance system for the early notification of community-based epidemics (essence) was expanded to look in detail at ed volumes and chief complaints of those patients who live outside of a 5-county tampa bay area. this analysis used patient zip code to determine place of residence. additionally, essence queries were utilized to look for heat, tear gas, and rnc related exposures. the essence system also receives poison control data every 15 minutes. expanded analyses of the poison control data were conducted as well. two disaster medical assistance teams (dmats) were deployed in tampa during the rnc. data was collected electronically and transmitted through essence as well. the hchd also asked infection preventionists, health care providers, hotels, labs, and mosquito control to lower their reporting threshold to us during the rnc period. we provided updates to all our partners with respect to diseases and outbreaks of public health importance occurring in our county. results no epidemiologic events linked to the rnc were detected through the hchd’s enhanced surveillance that was conducted. decreased patient volumes were seen during the rnc at our eds closest to the convention site. no significant increases in ed visits from outside of our 5-county area were noted during the rnc. urgent care centers reported seeing patients associated with the rnc for a variety of reasons including respiratory and gastrointestinal illness. dmat surveillance showed mainly routine visits but four secret service agents did seek care for respiratory illness during the convention. conclusions substantial time and resources were devoted to disease surveillance in the 6 months leading up to the rnc and during the event. while no epidemiologic events were detected, the public health surveillance infrastructure has clearly been strengthened in our county. we are receiving our ed syndromic data, from many of our hospitals, every two hours as opposed to every day. we have established relationships with our urgent case centers and hope to begin receiving urgent care center data on a daily basis in the near future. receiving dmat data through essence could prove very useful in the future, especially in florida where hurricanes are always a threat. lastly the improved relationships with our health care providers should be beneficial as we move forward. keywords mass gathering; national special security event; convention acknowledgments janet hamilton, aaron kite-powell, and aaron chern, florida department of health, bureau of epidemiology cynthia lewis-younger and joann chambers-emerson, florida poison information center –tampa dina passman, health and human services references hick j, frascone r, grimm k, hillman m, griffith j, hogan m, trotskysirr r, branu. health and medical preparedness and response to the 2008 republican national convention. disaster medicine and public health preparedness 3(4);224-232. kade k, brinsfield k, serino r, savoia e, koh h. emergency medical consequence planning and management for national special security events after september 11: boston 2004., disaster medicine and public health preparedness 2(3);166-173. *david atrubin e-mail: david_atrubin@doh.state.fl.us online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e68, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts framing the use of social media tools in public health jennifer stoll*, richard quartarone and miguel torres-urquidy centers for disease control and prevention, atlanta, ga, usa objective recent scholarship has focused on using social media (e.g., twitter, facebook) as a secondary data stream for disease event detection. however, reported implementations such as (4) underscore where the real value may lie in using social media for surveillance. we provide a framework to illuminate uses of social media beyond passive observation, and towards improving active responses to public health threats. introduction user-generated content enabled by social media tools provide a stream of data that augment surveillance data. current use of social media data focuses on identification of disease events. however, once identification occurs, the leveraging of social media in monitoring disease events remains unclear (2, 3). to clarify this, we constructed a framework mapped to the surveillance cycle, to understand how social media can improve public health actions. methods this framework builds on extant literature on surveillance and social media found in pubmed, science direct, and web of science, using keywords: “public health”, “surveillance”, “outbreak”, and “social media”. we excluded articles on online tools that were not interactive e.g., aggregated web-search results. of 2,064 articles, 23 articles were specifically on the use of social media in surveillance work. our review yielded five categories of social media use within the surveillance cycle (table 1). this framing within surveillance illuminates a range of roles for social media tools beyond disease event detection. [insert image #1 here] finally, we used the 1918 influenza pandemic to illustrate an application of this framework (fig 1), if it were part of the public health toolkit. in 1918, america was already becoming a “mass media” society. yet a key difference in mass communications today is the enabling of public health to be more adaptive through the interactivity of social media. results we used this “pre-social media” disease event to underscore where the real value of social media may lie in the surveillance cycle. thus for 1918, early detection of disease could have occurred with many, e.g., sailors aboard ships in new york city’s port sharing their “status updates” with the world. [insert image #2 here] after detection, social media use could have shifted to help connect and inform. in 1918, this could include identifying and advising the infected on current hygiene practices and how to protect themselves. social media would have enabled the rapid sharing of this information to friends and family, allowing public health officials to monitor the response. then, to support multiple intervention efforts, public health officials could have rapidly messaged on local school closures; they could also have encouraged peer behavior by posting via twitter or by “pinning” handkerchiefs on pinterest to encourage respiratory etiquette, and then monitored responses to these interventions, adjusting messaging accordingly. conclusions the interactivity of social media moves us beyond using these tools solely as uni-directional, mass-broadcast channels. beyond messaging about disease events, these tools can simultaneously help inform, connect, and intervene because of the user-generated feedback. these tools enable richer use beyond a noisy data stream for detection. table 1. social media use in supporting information for action fig. 1. social media mapping to 1918 epi curves for ny state (1). keywords surveillance; public health; social media references 1. goldstein e. et al. reconstructing influenza incidence by deconvolution of daily mortality time series. natl acad sci u s a. 2009 dec 22;106(51):21825-9 2. heaivilin n. et al. public health surveillance of dental pain via twitter. j dent res. 2011 sep;90(9):1047-51 3. luck, j. et al. using local health information to promote public health. health affairs 2006;25(4): 979-991 4. napolitano ma. et al. using facebook and text messaging to deliver a weight loss program to college students. obesity 2012 *jennifer stoll e-mail: jstoll@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e67, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts moh+: a global, integrated, and automated view of official outbreak reporting chi bahk*1,2, david scales1, sumiko mekaru1,3, john s. brownstein1,4,5 and clark freifeld1,6 1children’s hospital informatics program, division of emergency medicine, children’s hospital boston, boston, ma, usa; 2dept of global health and population, harvard school of public health, boston, ma, usa; 3dept of epidemiology, boston university school of public health, boston, ma, usa; 4dept of pediatrics, harvard medical school, boston, ma, usa; 5dept of epidemiology, biostatistics and occupational health, mcgill university, montreal, qc, canada; 6dept of biomedical engineering, boston university, boston, ma, usa objective to introduce moh+, healthmap’s (hm) real-time feed of official government sources, and demonstrate its utility in comparing the timeliness of outbreak reporting between official and unofficial sources. introduction previous studies have documented significant lags in official reporting of outbreaks compared to unofficial reporting (1,2). moh+ provides an additional tool to analyze this issue, with the unique advantage of actively gathering a wide range of streamlined official communication, including formal publications, online press releases, and social media updates. methods outbreaks reported by official sources were identified through moh+ (healthmap.org/mohplus), which collects surveillance data published globally by ministries of health (moh), other related ministries, government portals, government-affiliated organizations, and international governing bodies (fig. 1). reporting of these outbreaks was also identified in unofficial sources using various hm feeds including google news, promed, and participatory surveillance feeds. of the 109 outbreaks identified since may 2012, 65 were excluded as they started before data collection, 7 were excluded as they were not reported by unofficial sources, and 1 was excluded as it was a non-natural outbreak. for the remaining 36 outbreaks, the median difference in first date of report between official and unofficial sources was analyzed using a wilcoxon sign rank test. results outbreak reporting in official sources lagged by a statistically significant median of 2 days (p=0.003). among unofficial sources, online news most often (75%) was the fastest to report an outbreak, followed by promed (22%) and participatory surveillance (3%). among official sources, national government affiliated institutes were most often (41%) the fastest, and repeatedly providing prompt outbreak reports were the us centers for disease control and prevention (cdc), public health agency of canada, finnish food safety authority, health protection scotland, uk health protection agency, and french institute of public health surveillance (fiphs). following such institutes were the european cdc (ecdc) with 22% of first reports of outbreaks; moh’s (17%); and who (10%). there were 4 instances in which official sources reported before unofficial sources—3 by the ecdc and 1 by fiphs. conclusions compared to the chan study reporting a 16 day lag between first public communication and who outbreak news (1) and the mondor study reporting a 10 day lag between non-government and government sources (2), the present study shows a much condensed lag of 2 days between unofficial and official sources. because the two earlier studies cover a much broader historical time frame, one explanation for the reduced lag time is increased adoption of online communication by official government agencies. however, despite such improvements in communication, the lag persists, pointing to the importance of using informal sources for outbreak surveillance. the present study was limited by small sample size, as the study is in its early stages. we will continue to gather data and all numbers will be updated in time for the presentation to reflect the larger database. future directions of this study include characterization of official and unofficial reporting by region, language, disease, and source. fig. 1. interactive visualization of healthmap moh+, at healthmap.org/mohplus keywords disease surveillance; outbreak reporting; timeliness; moh; official sources references 1. chan et al. global capacity for emerging infectious disease detection. pnas 2010. 2. mondor et al. timeliness of nongovernmental versus governmental global outbreak communications. eid 2012. *chi bahk e-mail: cbahk@hsph.harvard.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e62, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts syndromic surveillance at the new york state veterinary diagnostic laboratory kylius wilkins*1, bruce akey2, 3, belinda thompson2, 3 and daryl nydam3 1veterinary services, usda aphis, ames, ia, usa; 2nysvdl, ithaca, ny, usa; 3cornell university, ithaca, ny, usa objective to assess the use and utility of a syndrome check list on the general submission form of a high volume veterinary diagnostic laboratory, and compare to the results of a 2009 pilot study. introduction the new york state veterinary diagnostic laboratory (nysvdl) receives more than 100,000 diagnostic submissions a year that are not currently used in any formal syndromic surveillance system. in 2009, a pilot study of syndrome classification schemes was undertaken and in 2011 a new general submission form was adopted, which includes a check list of syndromes, as part of the clinical history. monitoring submissions to a veterinary diagnostic laboratory for increases in certain test requests is an established method of syndromic surveillance (1, 2). the new general submission form allows for clinician selected syndromes to be monitored in addition to test request. methods we selected 420 “contract cases” from all submissions for bovines since the implementation of the new form, may 2011, though february 2012. submissions were reviewed for use of the new form, use of the syndrome check list and tests requested. test requests were assigned syndromes, if possible, to allow for comparison with the clinician selected syndromes. the selection of cases was weighted towards the end of the period as use of the new form increased with time and to a lesser extent toward the beginning of the period in an attempt to find any early use of the form. “contract case” refers to new york state department of agriculture and markets subsidization of agricultural animal and herd health testing done under specific guidelines. the benefit of “contract cases” is the guidelines require a complete clinical history, which should include selection of syndromes. finally, selection was limited bovine submissions as was done in the pilot study. results 16% (69/420) of submissions used the new form and of these 23 selected syndromes. as was seen in the pilot study the most commonly occurring syndrome in the clinical history was “gastrointestinal/diarrhea” 56% (13/23). the next most common syndromes were “respiratory” (7/23), “sudden death” (6/23) and “fever” (4/23). syndromes assigned based on test request followed a similar pattern with “gastrointestinal/diarrhea” (166/254) and “respiratory” (52/254) best represented. an important difference was the syndromes “sudden death” and “fever”, which were never assigned to a test request. these syndromes represent a new source of information for surveillance. these results fit well with the pilot study which found the clinical history was typically incomplete but contained additional information for syndromic surveillance that was not available from monitoring the test request alone and that monitoring syndromes or test requests alone would provide incomplete information nearly a third of the time. conclusions we found monitoring syndromes, in addition to test requests, to be useful and necessary for completeness. monitoring clinical history provided additional information not available from test requests alone. we recommend the syndromes “sudden death” and “fever” be monitored as these syndromes always provided additional information not available in test requests. other syndromes that provide new information should be investigated across species and in various clinical scenarios. accumulating baseline data for all syndromes is recommended to create more accurate models for syndromic surveillance and improve data retrieval for retrospective studies. despite poor use of the new general submission form and the syndrome check boxes, future compliance is likely to improve significantly with the implementation of online submission and thanks to the continuous training and consultation provided by the nysvdl staff. keywords syndromic surveillance; veterinary diagnostic laboratory; veterinary surveillance acknowledgments we would like to thank dr. robert gilmour and the cornell university veterinary investigator program for supporting this research. references 1. shaffer, l., funk, j., rajala-schultz, p., wallstrom, g., wittum, t., wagner, m., saville, w. (2007) early outbreak detection using an automated data feed of test orders from a veterinary diagnostic laboratory. in: d. zeng et al. (ed), biosurveillance 2007, pp. 1–10 2. glickman, l.t., moore, g.e., glickman, n.e., caldanaro, r.j., aucoin, d., lewis, h.b. (2006) purdue university–banfield national companion animal surveillance program for emerging and zoonotic diseases vector-borne and zoonotic diseases. 6(1), 14-23. 3. dorea, f.c., sanchez, j., crawford, w.r. (2011) veterinary syndromic surveillance: current initiatives and potential for development. preventive veterinary medicine 101, 1-17 *kylius wilkins e-mail: kmw97@cornell.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e104, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluating biosurveillance system components using multi-criteria decision analysis eric nicholas generous*1, alina deshpande1, mac brown1, lauren castro1, kristen margevicius1, william brent daniel1 and kirsten taylor-mccabe2 1defense systems analysis division, los alamos national laboratory, los alamos, nm, usa; 2bioscience division, los alamos national laboratory, los alamos, nm, usa objective the use of multi-criteria decision analysis (mcda) has traditionally been limited to the field of operations research, however many of the tools and methods developed for mcda can also be applied to biosurveillance. our project demonstrates the utility of mcda for this purpose by applying it to the evaluation of data streams for use in an integrated, global biosurveillance system. introduction the evaluation of biosurveillance system components is a complex, multi-objective decision that requires consideration of a variety of factors. multi-criteria decision analysis provides a methodology to assist in the objective analysis of these types of evaluation by creating a mathematical model that can simulate decisions. this model can utilize many types of data, both quantitative and qualitative, that can accurately describe components. the decision-maker can use this model to determine which of the system components best accomplish the goals being evaluated. before mcda can be utilized effectively, an evaluation framework needs to be developed. we built a robust framework that identified unique metrics, surveillance goals, and priorities for metrics. using this framework, we were able to use mcda to assist in the evaluation of data streams and to determine which types would be of most use within a global biosurveillance system. methods mcda was implemented using the logical decisions® software. the construction of the evaluation framework was carried out in several steps: identification and definition of data streams, metrics and surveillance goals, and the determination of the relative importance of each metric to the respective surveillance goal being evaluated. sixteen data streams types were defined and identified for evaluation from a survey we conducted that collected over 200 surveillance products. a subject matter expert (sme) panel was assembled to help identify the biosurveillance goals and metrics in which to evaluate the data streams. to assign values for the metrics, we referenced properties of data streams used in currently operational systems. results our survey identified sixteen different classes of data streams: ambulance records, clinic/ health care provider records, ed/ hospital records, employment/school records, established databases, financial records, help lines, internet search queries, laboraotry records, news aggregators, official reports, police/fire department records, personal communication, prediction markets, sales, and social media. four biosurveillance goals were identified: early warning of health threats, early detection of health events, situational awareness, and consequence management. eleven metrics were identified: accessibility, cost, credibility, flexibility, integrability, geographic/population coverage, granularity, specificity of detection, sustainability, time to indication, and timeliness. using the framework, it was possible to use mcda to rank the utility of each data stream for each goal. conclusions the results suggest that a “one size fits all” approach does not work and that there is no ideal data stream that is most useful for each goal. data streams that scored more highly for speed tended to rank more highly when the biosurveillance goal is early warning or early detection, whereas data streams that scored more highly for data credibility and geographic/population coverage ranked highly when the goal was situational awareness or consequence management. however, there are several data streams that rank consistently within the top 5 for each goal: internet search queries, news aggregators, clinic/ health care provider records, ed/ hospital records, and laboratory records and may be considered useful for integrated, global biosurveillance for infectious disease. keywords evaluation; biosurveillance; multi-criteria decision analysis; data stream; evaluation framework acknowledgments this project is supported by the chemical and biological technologies directorate joint science and technology office (jsto), defense threat reduction agency (dtra) *eric nicholas generous e-mail: generous@lanl.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e157, 2013 development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) wongyu lewis kim 1,2 , chelsea anne ducharme 2 , bernard jean-marie philippe bucher 3,4 1 university of illinois at chicago, 2 school of public health and health service, the george washington university, 3 centre international pour la coopération médicale et sanitaire dans la caribbean et les amériques, 4 university college london abstract dengue fever, including dengue hemorrhagic fever, has become a re-emerging public health threat in the caribbean in the absence of a comprehensive regional surveillance system. in this deficiency, a project entitled aricaba, strives to implement a pilot surveillance system across three islands: martinique, st. lucia, and dominica. the aim of this project is to establish a network for epidemiological surveillance of infectious diseases, utilizing information and communication technology. this paper describes the system design and development strategies of a “network of networks” surveillance system for infectious diseases in the caribbean. also described are benefits, challenges, and limitations of this approach across the three island nations identified through direct observation, open-ended interviews, and email communications with an on-site it consultant, key informants, and the project director. identified core systems design of the aricaba data warehouse include a disease monitoring system and a syndromic surveillance system. three components comprise the development strategy: the data warehouse server, the geographical information system, and forecasting algorithms; these are recognized technical priorities of the surveillance system. a main benefit of the aricaba surveillance system is improving responsiveness and representativeness of existing health systems through automated data collection, process, and transmission of information from various sources. challenges include overcoming technology gaps between countries; real-time data collection points; multiple language support; and “componentoriented” development approaches. keywords: outbreak, surveillance, syndromic surveillance, forecasting, emerging infectious diseases, caribbean, development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 introduction in 1999, the association of caribbean states (acs) recognized emerging infectious diseases as a major challenge after a large dengue fever epidemic in cuba and made a call for proposals for a comprehensive regional surveillance system. in 2005, a preliminary study entitled vigilia, was conducted from martinique to test strategies, models, and hypotheses for integrated surveillance in the caribbean. the pilot system demonstrated early warning capacity based on inference from collected data by correctly predicting an upcoming outbreak. martinique’s regional council and the centre international pour la coopération médicale et sanitaire dans la caribbean et les amériques (cicomsca) initiated a project entitled aricaba, meaning “to look” in the carib language. aricaba incorporates lessons learned from vigilia to implement a surveillance system across three islands: martinique, st. lucia, and dominica. this project has been funded by the european union with an approximately €3 million total budget (6). about aricaba aricaba, with cooperation of the regional council of martinique, st. lucia, and dominica governments, envisions a comprehensive emerging infectious disease surveillance system to detect and forecast threats and ultimately protect the citizens and visitors to the three participating islands. the mission of aricaba is to heighten protection of caribbean residents and visitors by closing the gap in existing infectious disease surveillance systems, especially emerging threats such as dengue fever and influenza. the combination of global and local partnerships; systems strengthening and integration; and the development of mathematical modeling will permit improved detection and forecasting of selected diseases. to accomplish this mission, the aim is to establish a network for epidemiological surveillance of infectious diseases, based on information collected through various sources of data. country background information it is essential to contextualize the countries in which the system will function prior to describing surveillance system design. understanding martinique, dominica and st. lucia is imperative to designing a surveillance system suitable for their social, economic, and political environments. table 1 illustrates background country information including health indicators and health systems (6). martinique martinique, colonized by france in 1635, remains one of several french overseas departments in the caribbean (4). it measures a total of 1,060 square km; the island is home to a mountainous terrain, tropical climate, and a five-month rainy season (4). the population is approximately 403,688 and inhabitants speak mainly creole and french (4). according to recent data, the gdp (ppp) was $4.5 billion. martinique is relatively more “westernized” and developed as compared to the other pilot countries (5). dominica dominica, located directly north of martinique, has a population of 72, 969 persons (4). presently an independent country, this 751 square km island is known as the “nature island” due to its lush, varied flora and rugged volcanic terrain. english is the official language though french patois, a form of creole, is widely spoken (4). dominica has the lowest income among the three pilot countries. politically, the dominican ministry of health is very well respected , including their development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 epidemiology unit. their health information technology unit is housed under the epidemiology unit which eases coordination among the two teams. st. lucia though possession transferred between britain and france fourteen times, st. lucia was granted independence in 1979 by england (4). bordering martinique to the south, approximately 161, 557 persons inhabit this tropical 606 square km island (4). english is the official language of this island (4). as an independent country, there exists a ministry of health, an epidemiology unit and a health information unit. st. lucia is currently developing its own surveillance system: sluhis. table 1. country information dominica martinique st. lucia basic information size 751 square km 1,060 square km 616 square km population 72,660 436,131 173,765 political status parliamentary republic, independent since 1978 overseas region of france, part of the european union parliamentary democracy, independent since 1979 gdp (purchasing power parity) $380 million $4.5 billion $1.75 billion health indicators life expectancy male: 72 years female: 76 years male: 79 years female: 78 years male: 72 years female: 78 years fertility rate 2.08 children born/woman 1.79 children born/woman 1.82 children born/woman probability of dying under five (per 1,000 live births) 15 7.44 14 % years lost due to communicable diseases 20% (not available) 17% existing health surveillance health information unit, carec, national public health surveillance and response team, national health information system in development health unit in general council of martinique, regional council of martinique (health planning) epidemiology unit, carec, national health information system in development development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 research methods aricaba project data was mainly collected through three three-month fellowships through the global health service fellow scholarship program at the center for global health at the george washington university from september 2010 to august 2011. data collection occurred in martinique, st. lucia and dominica, where the aricaba pilot project functions. data collection techniques include meetings, direct observation, open ended interviews and email communications with an in-site it consultant, key informants and project director, and direct observation; this data was shared openly among all fellows. information was also obtained through review of aricaba technical documents, literature reviews and web searches. key search words included surveillance system, syndromic, and outbreak detection. web search engines utilized include pubmed, md consult, science, and google. before surveillance system design, target infectious diseases were identified; dengue fever was chosen as a model for a vector-borne disease while influenza-like illnesses were chosen to represent man-to-man transmission (2). dengue fever and influenza-like illnesses were chosen for surveillance in this project based on prevalence, modes of transmission, and complexity (2). as a network of networks, the aricaba surveillance system ideally consists of linked databases of the three countries that connect to all public and private hospitals, public and private labs, community health center, pharmacies, airports and seaports. figure 1 shows that each country’s health system will link to its data collection points (dcps) and the dcps will link to a data warehouse where the automated early detection analyses will operate. in this paper, the design of the surveillance system will focus on the data warehouse rather than dcps since each dcp will be unique to the country’s it infrastructures and political structure (ex: health units). nonetheless, all stakeholders will provide necessary data that allows data analyses within the warehouse based on an agreed upon aricaba charter. the design of system of the data warehouse as well as data collection should ideally: monitor confirmed disease cases; forecast upcoming outbreaks; capture necessary data from dcps such as symptoms, meteorological conditions, overthe-counter (otc) sales, human migration, mosquito distribution, etc; and effectively disseminate data and information. likewise, the development strategies should meet the needs of: size and the operation system (os) of the aricaba data warehouse; information dissemination tools; and forecasting algorithms. development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 results design there are two components in the data warehouse. the first is a conventional disease monitoring system that collects suspected, probable, and confirmed cases; type of disease; and date of event and report. the other component is a syndromic surveillance system that collects syndrome of diseases from data contributors that allows automated epidemic detection for early warning systems. the rationale of having two components in one system is to maximize the system’s “software ergonomics” to match with the public health professional’s work flow (9). since public health professionals tend to spend more time with disease monitoring and intervention implementation rather than detecting the outbreak itself, the system should be able to detect the outbreak and also enable the ability to monitor the disease and progress of interventions spatially and temporally. therefore, the data warehouse will receive all data from the dcps. then, the syndromic system will function to detect the outbreak and the disease monitoring system will demonstrate the location and time of the outbreaks and allow evaluation of interventions. figure 1. network of networks overview development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 1) disease monitoring system as previously mentioned, the disease monitoring system will collect suspected, probable, and confirmed cases based on a case definition from health providers and laboratories to track the diseases retrospectively. this section will discuss case definition of dengue fever, dengue hemorrhagic fever, and influenza-like illness as well as data sources, contents, and dissemination method of the disease monitoring system. i) develop case definition a. dengue fever (2): i. suspected defined by the association of at least: sudden-onset high-grade fever (≥38.5°c) of less than 10 days duration, pain: headache ± joint pain ± muscle pain ± back pain, and lack of any infectious focus. ii. probable either a case of suspected dengue with at least two of the following clinical and biological criteria: skin rash minor signs of bleeding thrombocytopenia (platelets < 100,000/mm3) crp < 30 mg/l or a suspected case of dengue occurring during an outbreak. iii. confirmed a suspected or probable case of dengue confirmed by at least one of the following laboratory tests: mac-elisa of a single serum sample evidencing specific igm, serum culture or pcr identifying the dengue virus, significant rise in specific b. dengue haemorrhagic fever (2): fever with at least one haemorrhagic (bleeding) manifestations – i.e. purpura, epistaxis, hemoptysis, and melena -with or without jaundice. c. influenza like illness (2): i. suspected undifferentiated fever fever and respiratory symptoms ii) determine data source (type of system) the scope of data sources should focus on where, who, and when: geographic area, populations and time period to be covered. additionally, the scope must define how much data must be collected. in martinique, data sources are public and private hospitals, including the university hospital in fort de france, the largest hospital in martinique. private and public laboratories are also key development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 data sources. data should be collected on a weekly basis or a request basis, dependent on data. the amount of data should fulfill the list of data contents. in st. lucia and dominica, the main data source will be epidemiology unit databases in the department of health for the reported cases. laboratories, public, and private hospitals are also data sources dependent on it infrastructure. data should be collected on a weekly basis or a request basis, dependent on data. the amount of data should fulfill the list of data contents. iii) determine data contents from the data source, specific information about each individual, health care provider, or event should be collected. data contents for the disease monitoring system should describe the context of an outbreak including where, when, and to whom it occurred. the contents should be able to show types, sources, and treatment of diseases to assist in determining effective interventions. the data contents to be collected from data sources are date reported; disease; subtype; county; location name; date of event; latitude; longitude; diagnosis source; disease description; diagnosis date; dates of treatment; and date of death (see appendix i). ideally, data should be collected in real-time. however, every eight hours or daily reporting is acceptable. in addition, the data should be collected on a request basis. iv) develop data-collection instruments the resource to gather the data contents from the data sources should be identified. in martinique, the main instruments to collect the data will be computerized information systems such as email and web sites since it systems are available in health facilities. however, phone and fax can also be used. due to challenges in information systems and technology in low-resource settings such as st. lucia and dominica, phone and fax are currently important data collection instruments for hospitals, laboratories, and community health centers. computerized information systems should be implemented to enhance data collection speed and accuracy. v) develop and test analytic approach the collected data should be processed and analyzed. the data entry process will be separate from data coding in order to minimize data transcription or coding errors (9). during data entry, the staff member must check and edit data before entering into the data warehouse. routine analyses will be used for conditions of target diseases. baseline data will include five years of backlog reporting history in martinique, st. lucia and dominica. national data will be utilized for the unit of analysis, presenting time, person, and place. it must show whether or not the diseases have decreased or increased as a ratio in a weekly period (9). updated or corrected data will be used for later reports and analyses. a sensitivity and predictive value positive of the method must be presented. development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 vi) develop dissemination mechanism a data dissemination mechanism will focus on ensuring that those who need the information will receive it (9). after analyzing the data, the findings should be disseminated to public health officials and the public, if applicable. the findings from the disease monitoring system should be written as a report and must contain the number of hospitalized, number of deaths, and number of confirmed cases, including serotype. the dissemination mechanism for the data will be mainly web-based. public health officials or professionals will log into a secure web site to update the analyzed data and post a report. email is also suitable to send a report for key informants. important findings also should be available to the public through a website and computerized social networks such as facebook and twitter. vii) ensure use of analysis and interpretation it is important to evaluate the usefulness of data that is collected to those who use it (9). the evaluation will be conducted by a monthly survey to public health officials and professionals. also, web-statistics will be used to see how many people access which information and for how long. the survey will also include what other information would be useful in future analyses. 2) syndromic surveillance system the syndromic surveillance component will enable outbreak detection at early stages. this section will describe data sources and collection strategies; data analysis and outbreak detection methods; and data visualization, information dissemination and reporting of the aricaba syndromic surveillance system. the design of the syndromic surveillance system focuses on providing flexible and scalable infectious disease information, sharing (across species and jurisdictions), alerting, analyses, and visualization platforms (7,10). also, the system needs to support interactive, dynamic, spatial-temporal analysis of epidemiological textual and sequential data. i) data sources and collection strategies for the syndromic surveillance system, timely data should be provided with electronic prediagnosis health indicators (10). data sources for this system will include healthcare providers, schools, pharmacies, laboratories, and military medical facilities. from the source, data such as chief complaints from emergency department visits; ambulatory visit records; hospital admissions; otc drug sales from pharmacy stores; triage nurse calls; emergency calls; work or school absenteeism data; veterinary health records; laboratory test orders; and health department requests for influenza testing will be collected to monitor syndromes. it will also collect demographic data such as gender, age, area of residence and data relevant to patient visits. the syndromes to be monitored in this system include rash, fever, respiratory distress, hemorrhagic illness, severe illness, and death. development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 2. data collection and sources for the data warehouse disease monitoring database syndromic surveillance database collect data date reported disease subtype county location name date of event latitude longitude diagnosis source disease description diagnosis date dates of treatment date of death emergency department visit chief complaints, ambulatory visit records, hospital admissions, over the counter (otc) drug sales from pharmacy stores, triage nurse calls, emergency calls, work or school absenteeism data, veterinary health records, laboratory test orders and results, health department request for influenza testing data sources healthcare providers laboratories healthcare providers schools pharmacies laboratories military medical facilities. monitoring suspected cases confirmed cases (including types) number of hospitalized number of death rash fever respiratory hemorrhagic illness severe illness and death based on the data collection and source identified, figure 3 shows main entities and attributes of the aricaba syndromic surveillance system in the database. development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 figure 2. aricaba erd (entity relationship diagram) for the collection strategy, these data will be collected in real-time through hl7 messages from other computer systems such as registration systems and laboratory information systems, over a secure shell-protected internet connection in an automated mode. for effectiveness and validity of data usage for illness pattern detection, it is important to consider a possible time lead compared with diagnosis (10). for example, it should compare chief complaints and discharge diagnosis to cross check from multiple sources to ensure similarity. development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 ii) data analysis and outbreak detection in order to analyze collected data for outbreaks, the first step is to define syndrome classifications (3). it will apply a keyword classifier and icd-10 classifier to chief compliant data for a syndrome classification. as a syndrome classifier, the chief complaint coder (coco) module, which is based on bayesian classifiers and has been used in the real-time outbreak and disease surveillance (rods) system in the university of pittsburgh, will be utilized. the co-co module has been proven effective through the rods system. since the size of the geographical tested area of the rods system is similar to the aricaba project, the co-co module may also be an effective syndrome classifier for the aricaba project. therefore, data analysis and outbreak detection algorithms of rods can be modified and applied to aricaba’s data analysis and outbreak detection algorithms. iii) data visualization, information dissemination, and reporting like the disease monitoring system, it is important to make available a sophisticated spatialtemporal visualization environment to help visualize public health case reports and analyze results in both retrospective and prospective spatial-temporal clustering approaches (zeng 2008). the aricaba syndromic surveillance system will provide multiple graphing techniques with both time-series and geographical displays available via password-protected web interface. it must be able to provide the following (10): time-series plots updated on each syndrome daily. the user will be able to view these graphs by county or for the three countries. an interactive view categorized by the syndrome, region, start dates, and end dates, to generate customized time-series plots. location mapping by use of geographic information system (gis), which can display disease cases’ spatial distribution using patients’ zip code information. development strategies this paper will focus on development of the software and exclude hardware requirements. the hardware requirements will be determined based on the volume of data from the dcps and the internet connection capacity. thus, we will discuss the software for the server such as operating system (os), database, web interface, programs for data analysis, and the geographical information system (gis) for data visualization. data warehouse data warehouses will be implemented in martinique because it has the most advanced it infrastructure among the three countries. the data warehouse will be linked to dcps to receive the collected data (figure 3). the collected data will go through an extract, transform and load (etl) process for data cleaning (figure 3). development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 microsoft windows server 2008 will be used as the os. the rationale for selecting a windows server system instead of a linux or sun system is due to ease of it technician recruitment for windows system in martinique; it is important to consider local it human resources for creation of it systems in developing countries. er win 4.0 is used to develop the entity relationship diagram (erd), which allows development of a logical and a physical model of data modeling for the data warehouse. the erd is developed based on a platform of microsoft sql server. the data warehouse will also have a data mart for data analysis through mathematical algorithms. the server will provide internet information service (iis) web service for a web site. the web interface will be developed with asp.net language in order to display data, provide interactive user-interface via the website. the data warehouse will also provide a gis application server component with arcims (figure 3). these web and gis servers will be implemented in a separate server machine in order to lessen the burden of the data warehouse. a. disease monitoring system figure 3. data warehouse architecture development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 b. syndromic surveillance system geographical information system gis will be developed to demonstrate mappings of the incidence and prevalence of diseases and health facilities for interventions. the arcgis 9.3 version will be used as the gis system. the mapping of incidence and prevalence of diseases will be developed for all three countries: martinique, st. lucia, and dominica. therefore, incidence and prevalence of disease data must include location, including longitude and latitude. health facility mapping must also be developed among the three countries. health facilities include public and private hospitals, clinics, and laboratories. for more interactive maps, arcgis api for flex will be used to create a flash file for the web. forecasting algorithm for the outbreak detection algorithms, multiple forecasters will be used for outbreak detection algorithms to minimize the expected squared error of the forecast. outbreak detection algorithms include cumulative sums (cusum), smart, scan statistics, recursive least squares (rls), wavelet-detection algorithms, and what is strange about recent event (wsare). several of these algorithms will be used in order to compare the results. first, a combination of cusum and ewma will predict next-day counts and monitor the differences between the cumulated average and predictions. the second monitoring tool will be a recursive least squares (rls) algorithm, which fits “an autoregressive model to the counts and updates estimates continuously by minimizing prediction error” (8). the third tool will include a wavelet approach, which “decomposes the time series using haar wavelets, and uses the lowest resolution to remove longterm trends from the raw series” (8). the residuals are then monitored using an ordinary development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 shewhart i-chart with a threshold of 4 standard deviations (8). by comparing these algorithms, it will monitor whether all the monitoring tools predict similar patterns, rather than relying on one forecasting algorithm. in developing a forecasting algorithm, data clustering will be performed to organize the pattern of data, based on similarity. afterward, regression analysis will be conducted to find a relationship (coefficients) between the data. pasw (spss modeler 13) will be used for the analysis. the pattern of data and associated factors will be plugged into a mathematical algorithm that incorporates environmental characteristics such as weather conditions and mosquito distribution to develop an outbreak forecasting algorithm for dengue fever. for the mathematical algorithm, holt winter’s multiplicative seasonality model will be tested in the pilot. discussion benefit of the aricaba surveillance system and design one of the main benefits of the aricaba surveillance system is that it will improve responsiveness and representativeness of the existing health systems in the three countries through an automated approach of the collection and processing of data and transmission of information from various sources. by doing so, the network system will homogenize and organize the data that are collected from relevant stakeholders in dominica, st. lucia and martinique, utilizing information and communication technology. by incorporating a disease monitoring system for confirmed cases and a syndromic surveillance system for forecasting, it will empower public health professional to prepare and intervene effectively when outbreaks occur. detection algorithm in a syndromic surveillance system, one of the keys for accurate outbreak detection is well designed and tested mathematical algorithms. although the aricaba syndromic surveillance system uses the basic idea of the rods’s mathematical model, it is important to develop its algorithms from feedback in order to capture and predict the outbreak in the caribbean. it is crucial to continuously question what other algorithm combinations are available and investigate lesson learned from other syndromic surveillance systems. data collection in order for the data warehouse to function properly, a strategic plan for collecting data is critical. necessary data for the data analysis must be collected in sufficient amounts. in addition, data collection should occur in a timely and complete manner while following agreed upon data standards. hospitals, labs, and clinics have different data systems in each country. when each dcp collects data from the data sources, each dcp must be able to convert the data into data warehouse system. however, the absence of medical informatics and electronic medical record systems in martinique and dominica remains a challenge. system requirements system requirement must take the volume and size of data into account. it must consider the data such as the list of syndromes, weather conditions, and migration to be collected from the three islands. in addition, it is important to design system requirements in a flexible manner so that the development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 system can expand in case of increased data volume in the future. the system requirement for the data warehouse should also consider the performance capacity of cpu and ram for calculating the outbreak detection algorithms. sensitivity vs. specificity a critical component regarding the algorithms for outbreak detection is balancing the level of specificity. for example, if the system has specificity set to low, there will be a lot of "falsepositive" epidemic alerts, which will tire the system. on the other hand, if it is too specific, the system may miss true epidemics, which does not meet the purpose of the system either (2). technology gaps since the level of economic development in all three countries is different, it is important to consider the technology gaps among the islands. not only internet capacity, but more importantly, the gap in medical informatics is an immense challenge to implement automated data collection from hospitals and laboratory. the automated, real-time chief complaint collection from emergency departments or clinics is especially crucial for a syndromic surveillance system; implementing adequate medical informatics system in hospitals among the countries must be completed first in order for the syndromic system to remain fully functional. another way to overcome the technology gap is to utilize a “component-oriented” development approach, which develops each component of system separately so that it can be a “plug-in” to other systems when needed. languages as mentioned, the three countries speak different languages. among a mixed language setting, it is important to establish multiple language systems for the entire surveillance system. for example, all data should be displayed in french, english and creole. also, data translation features are necessary to communicate between the three countries. for instance, data or information entered in english in st. lucia should be able to be read as french in martinique; this highly interactive language feature remains a challenge. limitations this study involved several limitations. a holistic, contextual view of this project was not analyzed; only certain aspects of the parts of the project have been analyzed. therefore, causal conclusions were difficult to obtain. for example, time in the fellowship was a limiting factor in accessing data; budget and cost-effective analyses could have been valuable quantitative information but were not completed. additionally, a possibility of observer and interviewer bias in handling the qualitative data exists. there may be interviewer bias in handling the data because a majority of technical concepts originate from martinique. observer bias in collected data is reduced due to three fellows working on the project with different backgrounds and expertise. in addition, the areas in which fellows worked vary with some overlap. however, the information from different perspectives enriches the perspective and qualitative analysis of this study. finally, a lack of technical documentation limited this study to rely mainly on interviews and discussion. conclusion the aricaba surveillance project was initiated to protect caribbean citizens and tourists from development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 emerging infectious diseases by using network systems for early warning and forecasting. the aim is to implement a comprehensive surveillance system that enhances health systems by connecting current structures and maximizes its capacity through information technology in the caribbean, where resources are limited. this paper recommends a system architecture and database system for data warehousing. it proposes two systems: a disease monitoring system and a syndromic surveillance system within the data warehouse to predict the outbreak and monitor/control the disease. data contents, sources, collection and visualizations strategies have also been suggested. however, collecting data, especially chief complaints from ers in real-time, remains a challenge where medical informatics system are limited. also, full language support for the entire system is complex. considering these challenges, recommendations include reducing technology gaps, in terms of medical informatics, between three countries; improving real-time data collection for the syndromic surveillance system; and establishing multi-language support system. for development strategies, “component-oriented” development approaches are recommended for the sustainability of aricaba. the caribbean region should continue to move forward in their efforts to improve surveillance systems and protect the health of their citizens. acknowledgements we would like to acknowledge cicomsca and the regional council martinique for their support of this project. additionally, many thanks to the center for global health at the george washington university for the opportunity to participate with aricaba through their global health service fellowship. references [1] bliss k. health in latin america and the caribbean: challenges and opportunities for u.s engagement, center for strategic and international studies global health policy center. 2009; washington, dc. [2] bucher b. aricaba: an emerging infectious disease surveillance system, implementation & evaluation plan. 2010; martinique. [3] chen h. ai for global disease surveillance, ieee computer society. 2009: 118. [4] central intelligence agency (cia). the world factbook [internet]; [cited october 15, 2011]. available from: https://www.cia.gov/library/publications/the-world-factbook/ [5] dieye m. cancer incidence in martinique: a model of epidemiological transition. european journal of cancer prevention 2007apr; 16(2):95-101. [6] ducharme c. understanding implementation barriers to an electronic emerging infectious disease surveillance system in the caribbean, aricaba: a case study. 2011; the department of global health, the george washington university, washington d.c. [7] heymann d, rodier g. global surveillance of communicable diseases. emerging infectious diseases. 1998; 4(3):362-65. https://www.cia.gov/library/publications/the-world-factbook/ development and implementation of a surveillance network system for emerging infectious diseases in the caribbean (aricaba) 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [8] shmueli g, burkom s. statistical challenges facing early outbreak detection in biosurveillance. technometrics (special issue on anomaly detection). 2010; 52(1): 39-51 [9] teutsch s. principles and practices of public health surveillance, 2nd. ed. new york: oxford university press; 2000. 406p. [10] zeng d. syndromic surveillance systems: public health and biodefense. review of information science and technology (arist) [internet]. 2008 [cited 2011 july 15]; 42. available from: http://iasec.eller.arizona.edu/docs/zeng-survey-manuscript-revised.pdf [11] zeng d. infectious disease informatics and outbreak detection. medical informatics. new york: springer science; 2005. 647p. layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts the use of the international classification of diseases, ninth revision (icd-9) coding in identifying chronic hepatitis b virus infection in health system data: implications for surveillance reena mahajan*1, anne c. moorman1, stephen j. liu1, loralee rupp2, monina klevens1 and (checs) for the chronic hepatitis cohort investigators3, 2, 1 1centers for disease control and prevention, atlanta, ga, usa; 2henry ford health system, detroit, mi, usa; 3kaiser permanentehawaii; geisinger health system, pennsylvania; kaiser permanente-northwest, oregon, atlanta, ga, usa objective to evaluate the sensitivity, specificity, positive and negative predictive values of the icd-9 coding system for surveillance of chronic hepatitis b virus infection (hbv) using data from an observational cohort study in which icd-9-coded hbv cases were validated by chart review. introduction in the united states, 800,0001.4 million people are chronically infected with hepatitis b virus (hbv); these persons are at increased risk for chronic liver disease and its sequelae (cdc, 2010; wasley, 2010). current national viral hepatitis surveillance is a passive laboratory-initiated reporting system to state or local health departments with only 39 health departments reporting chronic hbv infection in the national notifiable disease surveillance system (nndss). since active hbv surveillance can be expensive and labor-intensive, the icd-9 coding system has been proposed for surveillance of chronic hepatitis b. methods we examined the electronic health records (ehrs) available as part of an existing cohort study of persons with chronic viral hepatitis. records from 1.6 million adult patients who had one or more services from 2006-2008 in four integrated health care systems were reviewed. complex algorithms using laboratory data and/or use of qualifying hepatitis b icd-9 codes were applied to ehr patient data to create the chronic hbv cohort. disease status was manually validated by abstractor review of the medical record. sensitivity, specificity, positive and negative predictive values were calculated based upon presence of either one hepatitis b-specific icd-9 code or two such icd-9 codes separated by at least six months. results of 1,652,055 adult patients, 2,202 (0.1%) met criteria for inclusion into the chronic hbv cohort. of the 2,202 confirmed cases, the sensitivity of use of one icd-9 code was 83.9%, positive predictive value was 61.0%, specificity was 99.9% and the negative predictive value was over 99.9% (table 1). in comparison, use of two hepatitis b-specific icd 9 codes separated by six months, resulted in a sensitivity of 58.4%, a positive predictive value of 89.9%, and specificity and negative predictive value similar to use of one icd 9 code. conclusions our findings suggest that use of one or two hepatitis b specific icd 9 codes can identify cases with chronic hbv infection. for health departments with access to electronic medical records, collection of icd-9 data may be useful for surveillance and potentially improve reporting of chronic hbv infection. measurement of sensitivity, specificity, and predictive values of using one hepatitis b-specific icd-9 code among persons receiving services from four health care systems from 2006-2008 sensitivity= 1,847/2,202= 83.9% specificity= 1,648,671/1,649,853= 99.9% positive predictive value= 1,847/3,029= 61.0% negative predictive value= 1,648,671/1,649,026= >99.9% keywords surveillance; hepatitis b virus; icd-9 acknowledgments the authors thank dr. fujie xu, division of viral hepatitis, centers for disease control and prevention for her helpful suggestions with this study. references 1. cdc, 2010. viral hepatitis statistics and surveillance. http://www.cdc.gov/hepatitis/statistics/index.htm. accessed july 20, 2012 2. wasley a, kruszon-moran d, kuhnert w, simard ep, finelli l, mcquillan g, et al. the prevalence of hepatitis b virus infection in the united states in the era of vaccination. j infect dis 2010;202:192201. *reena mahajan e-mail: rmahajan1120@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e26, 2013 subjective well-being and personality traits: towards personalized persuasive interventions for health and well-being. personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi personality and subjective well-being: towards personalized persuasive interventions for health and well-being. aisha muhammad abdullahi 1, rita orji 2, abbas muhammad rabiu, 1 abdullahi abubakar kawu 3 1faculty of computing, federal university dutse, nigeria, 2faculty of computer science, dalhousie university, halifax canada, 3ibrahim badamasi babangida university, lapai 740005, nigeria abstract subjective well-being (swb) is an individual’s judgment about their overall well-being. research has shown that activities that elevate people’s sense of swb have a significant effect on their overall health. there are two dimensions of swb: affective and cognitive dimensions. however, studies on swb usually focus more on one dimension, ignoring the other dimension. also, most existing studies on swb focused on individuals from western cultures. research has shown that the influence of personality on subjective well-being is moderated by culture. thus, to advance research in personalizing persuasive health interventions, this study focuses on africans (n=732). specifically, we investigate the relationship between the big-five personality traits and both dimensions of swb using the constructs: happiness, satisfaction with life, social, psychological and emotional well-being. our results reveal that health informatics designers who design persuasive technologies to promote swb would need to tailor designs along personality traits and swb constructs. accordingly, for users high in agreeableness, the design should be focus on promoting their feelings of happiness and social wellbeing. for users who exhibit neuroticism, designers should focus on designing to promote psychological wellbeing and emotional well-being. based on our findings, we offer guidelines for tailoring persuasive health interventions to promote individuals’ swb based on their personality. we thus highlight areas that personal health informatics design can benefit. ccs concepts • human-centered computing → personalization → hci design and evaluation methods → user models keywords subjective well-being, big five personality traits, persuasive health applications, personalization. correspondence: am.abdullahi@fud.edu.ng, rita.orji@dal.ca, mambas86@fud.edu.ng, abdullahikawu@ibbu.edu.ng doi: 10.5210/ojphi.v12i1.10335 copyright ©2020 the author(s) this is an open access article. authors own the copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without the permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 1. introduction according to the world health organization, “health is a state of physical, mental and social wellbeing and not merely the absence of disease or infirmity” [1]. in 2012, the united nations emphasized the importance of individual and societal wellbeing in achieving the millennium development goals [2]. as a result, it has been advocated that health interventions focus on promoting health and well-being by targeting the individual components that contribute to them. subjective well-being is an individual’s judgment about their overall well-being, which includes a cognitive dimension (satisfaction with life and happiness) and an affective dimension (social well-being, emotional well-being, and psychological well-being) [3]. research has shown that there is a relationship between people’s subjective well-being and their physical health [4,5]. for example, skaff et al. [6] showed in their study that negative emotions predicted rising blood glucose levels the next day and black et al. [7] explains how stress leads to inflammation, which can harm health when it is chronic. it has also been found that surgical patients healed more quickly if they are high in life satisfaction [8]. this suggests that interventions that raise people’s sense of well-being may contribute to improving physical health. thus, theories on how to promote people’s subjective well-being have been established [9,10]. some existing personal health informatics (self-tracking) tools provide some level of personalization, but the focus is largely on the aesthetics of the tool. most consumer products have aesthetic ways to customize the tools—both software (e.g., color, user information, a wide variety of user interface designs to choose from) and hardware (e.g., medium, form factor, and types), thereby reducing the devices prospective benefits to the user [11]. for example, during setup, fitbit asks people to enter details for their profile, such as gender and height, from which they estimate a number of health information such as bmi (used for managing body weight). although important, these personalization supports fall short of realizing the full potential of personalized tracking because they are applied to the secondary side of the tracking tool, not towards the subjective circumstance and lived experience of the user (such as their mood or mental state at the time of use) especially in technologies that intend to persuade or change behavior. when self-tracking tools do not completely satisfy personalization and by implications tracking needs, people give up tracking entirely [12]. to accommodate a wide range of tracking needs, designers should identify ways to incorporate the subjective situations of users while using the health tracking tools as attempted in omnitrack [13]. this realization has motivated a shift of pt design from the traditional one-size-fits-all approach to a personalized approach that adapts to the preferences of individuals. the personalized approach treats each user as a different entity, it assumes that a persuasive strategy that works for one user may not work for another. therefore, persuasive health interventions need to be tailored to users to be effective [14]. as a result, research into personalizing health interventions to individual preferences has gained some attention among pt designers. specifically, research into investigating personality traits as personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi a factor that can influence individual differences attracted the attention of researchers [15,16]. this is because what constitutes well-being for one may not for another. however, most existing literature focuses on individuals from western culture. there is limited literature on the generalization of their findings to individuals from developing countries. research has shown that the influence of personality on the subjective well-being components is moderated by culture [17]. also, most existing literature focuses on one dimension of subjective well-being ignoring its other dimension. therefore, in this paper, we investigate the relationship between personality traits (openness, conscientiousness, extraversion, agreeableness, neuroticism) and the two dimensions of subjective well-being (affective dimension and cognitive dimension) using distinct subjective well-being components (satisfaction with life, happiness, psychological, social and emotional well-being) in people from africa (nigeria specifically) to outline ways that persuasive health interventions can be personalized to be more effective for people from non-western cultures based on their personalities. to achieve this, we conducted an empirical study (n=732), using structural equational model (sem) analysis to develop a model showing how people of different personalities relate to various subjective well-being components. interestingly, our results reveal that personality traits play significant roles in their various subjective well-being components. for example, to design pts to promote swb for people high in agreeableness, designers should focus on designing to promote their feeling of happiness and social well-being, while for neuroticism, designers should focus on designing to promote psychological well-being and emotional well-being. our work offers four main contributions to the field of persuasive technology and health intervention design. first, we reinforce the need to personalize persuasive health systems by revealing that individuals of different personality traits relate differently to distinct subjective wellbeing components. second, we establish that personality trait is an important characteristic for personalizing persuasive health interventions targeting african audience. so far, none of the existing works investigated the relationship between personality and subjective well-being among africans. third, we examine the relationship between individual personality traits and the different subjective well-being components and develop design guidelines for personalizing persuasive health applications to individuals based on their personality traits. finally, we suggest some persuasive strategies to promote individual components of subjective well-being. this is an essential step toward developing personalized health applications that will effectively engage users and promote desired behavior change. 2. background and related work in this section, we provide an overview of personality traits, subjective well-being, and related work. 2.1 personality traits personality traits are the combination of habitual behaviors, cognitions and emotional patterns that make up an individual's distinctive character [18]. psychologists argue that personality is unique to everyone [19]. understanding your personality and what makes you different from others, can personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi lead to better life choices. personality traits have been shown to play important roles in people’s well-being and overall success [20]. this may be because personality traits are significant predictors of our behaviors and attitudes in life. over the years, several tools for identifying personality traits have been developed. among these tools are the myers-briggs type indicator (mbti) [21], pen model [22] and big five [23]. the big-five personality traits– openness, conscientiousness, extraversion, agreeableness, neuroticism is the most widely used personality type. the big five personality traits have been shown to influence subjective wellbeing among other populations, for example, south koreans [15], taiwanese [16] and spaniards [24]. these five components are: 1. openness personality trait describes how open someone is to a variety of experiences or how concretely or abstractly someone thinks about things. those high in this trait tend to hold unconventional values and are often creative thinkers. 2. conscientiousness personality trait describes how self-disciplined, organized and goal-oriented a person is. those high in this trait tend to be good at planning rather than being spontaneous. 3. extraversion is a personality trait characterized by how sociable, energetic and warm a person is. those high in this trait tend to be chatty and associate a lot with others. 4. agreeableness personality trait describes how kind, sympathetic and cooperative a person is. those high in this trait tend to be helpful, less competitive and friendly to others. 5. neurocism describes how emotionally unstable, nervous, distressful and fearful a person is. those high in this trait tend to worry or be temperamental. 2.2 subjective well-being the term subjective well-being refers to people’s perception and evaluations of their lives, and well-being, including cognitive evaluation, such as satisfaction with life and affective evaluation such as emotional, social and psychological well-being [3]. people’s subjective well-being has been widely acknowledged to play an important role in their overall physical and mental health. as a result, the past four decades have witnessed an explosion of research on the design for wellbeing [25-27]. the most widely accepted definition of subjective well-being distinguishes the cognitive and an affective dimension of subjective well-being [3,15,28]. the cognitive dimension is based on an overall assessment of one's life. peoples’ happiness and satisfaction with life are considered a cognitive component of subjective well-being [28]. researchers have used the happiness scale and satisfaction with life scale to assess the cognitive dimension of swb [15]. the affective dimension reflects the number of pleasant feelings (positive affect) and unpleasant feelings (negative affect) that people experience in their lives [28]. the affective dimension of swb brings measurement very close to assessing mental health [28]. some researchers have used the positive affect scale and negative affect scale to assess the affective dimension of subjective well-being [24]. however, to have broader and richer information about the affective dimension of subjective well-being, several researchers have used the psychological well-being, social wellpersonality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi being, and emotional well-being scales to assess the affective dimension of subjective well-being [29,30]. in this study, the satisfaction with life, happiness, psychological, social and emotional well-being scales is used to assess participants' overall subjective well-being. we discuss these five components briefly in this section. 1. satisfaction with life is defined as one's evaluation of life and how they feel about their directions and options for the future [31], or people’s judgment that at least on balance, their life measures up favorably against their standards or expectations [32]. research has shown that satisfaction with life is a predictor of health-related quality of life (hrqol) [33]. for example, strine et al. [33] in their study revealed that as the perceived life satisfaction of people decreased, the prevalence of unhealthy behaviors that contributes to general ill-health increases. this includes smoking, obesity, physical inactivity, heavy drinking, sleep deprivation, and chronic illnesses. thus, persuasive technological interventions aimed at increasing an individual’s well-being can target promoting their overall feeling of satisfaction with life as a way of fostering well-being. 2. happiness is defined as the momentary feeling of intense joy [34]. it has been shown that happy people are healthier [35]. therefore, a persuasive intervention designed to increase an individual’s overall happiness will likely impact on their health and well-being. 3.psychological well-being is defined as the general perception experienced by individuals that there will be positive outcomes to events or circumstances (p. 497) [36]. ryff described six key-elements of psychological well; self-acceptance, personal growth, purpose in life, environmental mastery, autonomy and positive relations with others [37]. these six elements are key to positive psychological well-being. positive psychological well-being makes people better able to deal with life’s challenges which in turn promotes other desirable qualities like creativity, productivity, and vitality. a frequent experience and expression of positive psychological well-being make people more optimistic, resilient, and resourceful. also, research has shown that people who have positive psychological well-being are healthier generally [38]. therefore, a persuasive intervention designed to increase an individual’s psychological well-being may have a positive effect on their overall health and well-being. 4. social well-being refers to an individual’s interaction and relationship with others. “it involves using good communication skills, having meaningful relationships, respecting yourself and others, and creating a support system that includes family members and friends” [39]. high social well-being makes it easy for people to build and maintain positive relationships with others and their community. it has been shown that people who experience a high sense of belonging in various cultural activities and within their communities are generally healthier [40]. for example, barton and grant’s [41] showed that people who belong to socially excluded groups have poorer health than their counterparts. therefore, a persuasive intervention designed to increase an individual’s social well-being may have a positive influence on their overall health and well-being. personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 5. emotional well-being is defined as a feeling of relaxation and stress freeness [42]. emotional well-being reflects how well individuals manage their thoughts, feelings, and actions to function in their everyday lives. it has been shown that people’s emotional well-being influences their mental health [28]. positive emotional well-being is key to experiencing balanced mental health and overall well-being. research has shown that people who have positive emotional health are better able to cope with everyday stresses and problems and therefore have more stable mental health and overall well-being [43]. more specifically, the studies of burnner [44] and wilkinson [45] revealed that emotional distress creates susceptibility to physical illness by affecting the immune response, thus leading to poor health conditions. therefore, a persuasive intervention designed to increase an individual’s emotional well-being will likely impact positively on their overall health. 2.3 related work investigating the relationship between personality traits and swb has received some attention and has been studied extensively by previous literature [15,16,24]. for example, ha et al [15] in their study showed that there is a statistically significant relationship between personality traits and subjective well-being. in their study of south koreans, they explored the direct influence of personality on subjective well-being. however, the study focused on one dimension of subjective well-being (the cognitive dimension) ignoring its other dimension (the affective dimension). the cognitive dimension was measured using happiness and life satisfaction scales. ha et al [15] found that personality traits, particularly emotional stability and extraversion, are positively associated with happiness and life satisfaction. similarly, gutiérrez et al. [24] revealed that personality is an important correlate of subjective well-being. they conducted a study of spaniards to examine the association between, personality traits and subjective well-being. still, the study focused on one dimension of subjective well-being (the affective dimension) ignoring its other dimension (the cognitive dimension). they used the positive affect and negative affect scales. gutiérrez et al. [24] revealed that neuroticism and extraversion correlate with the two components used to measure subjective well-being (positive and negative affect) while openness and agreeableness correlate with only one of the two components (positive affect). a recent study by chen [16] also showed a significant and substantively important relationship between personality traits and subjective well-being. chan [16] investigated the relationship between personality traits and the subjective well-being of online game playing teenagers in taiwan. the study also assessed one dimension of subjective well-being (the cognitive dimension), using the satisfaction with life scale. the study concluded that, neuroticism ana d agreeableness have significant negative influence on people’s satisfaction with life while and openness has significant positive influence on satisfaction with life. also, soto [46] showed a significant relationship between personality traits and components of subjective well-being. in his study, with australians, he explored the relationship between personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi personality traits and subjective well-being using satisfaction with life, positive affect, and negative affect scales. he found that individuals with more-extraverted, agreeable, conscientious, and emotionally stable personalities tend to experience higher life satisfaction, more frequent positive affect, and less frequent negative affect. furthermore, costa et al. [47] carried out a study of participants from boston, usa, focusing on one dimension of subjective well-being (the affective dimension). they found that extraversion is positively associated with positive affect and neuroticism is positively associated with negative affect. another study by deneve and cooper [48] used four components: life satisfaction, happiness, positive affect, and negative affect, to assess subjective well-being. they found that neuroticism is strongly associated with life satisfaction, happiness, and negative affect, while extraversion and agreeableness are strongly associated with positive affect. in a similar study, libran [49] used life satisfaction, positive affect, and negative affect scales to assess the subjective well-being of university students in catalan, span. as regards personality traits, he considered only the extraversion and neuroticism traits. results from his work show neuroticism as one of the most important correlates of the components of subjective well-being. specifically, he found that neuroticism is strongly negatively associated with life satisfaction and positive affect, but strongly positively associated with negative affect. on the other hand, extraversion correlated positively with satisfaction with life and positive affect, but not with negative affect. his study concluded that the correlations of neuroticism with the components of subjective well-being are higher than those obtained between these same components and extraversion. that is, extraversion seems to be less significant than neuroticism as a predictor of the components of subjective well-being. this present study differs from existing studies in three major ways: one, we investigate a developing african nation (nigeria) which is often neglected by researchers. two, we investigate both dimensions of subjective well-being and their relations with personality. happiness and satisfaction with life are used to assess the cognitive dimension while the three components of psychological well-being, emotional well-being, and social well-being are used to assess the affective dimension. this provides a richer insight into subjective well-being. three, we offer design guidelines and design considerations to inform persuasive health intervention design especially those targeted at african audiences. 2.3 health informatics and subjective well-being. health informatics (hi) is an area with wide applications to encompass public and personal health informatics [50]. while public health informatics refers to the systematic application of information and computer science and technology to public health practice, research, and learning [51], personal health informatics focus on the collection and use of personal data, often from trackers and life-loggers for achieving specific health goals for individuals [52]. in both realms, some sentiments infer that the current state of technologies can benefits from other dimensions of improvement, beyond software and hardware. tracking circumstance and subjective situations could mean support towards measuring other dimensions of ‘improvements’ personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi [52] that go beyond activities, soft or hardware. this may thus include subtle dimensions like the account of swb and personality traits. although, this is somewhat difficult in practice [11] and can be challenging from user experience and privacy perspectives [53], we believe it may fit mccarthy and wright’s discussion of “technology as experience” [54] and their call for design to engage with the felt life. 3. method this study was designed to investigate how people of different personalities relate to the two subjective well-being dimensions (cognitive and affective) using five components satisfaction with life, happiness, psychological, social and emotional well-being. this will inform the tailoring of persuasive health interventions to the personalities. to achieve this, we collected data about participant’s personality traits and their subjective well-being components and conducted structural equational model (sem) analysis, specifically, path analysis using amos 2.0. 3.1. sample and sampling technique the sample was drawn from north-west nigeria in 2018. seven states were selected: kano, kaduna, katsina, kebbi, sokoto, jigawa, and zamfara. 100 participants were randomly selected in all the states except for kano were 132 participants were selected. universities, colleges, government/private offices from these states were randomly enlisted and personally visited by the research team. after a short introduction of the study to the head of each organization, participants were then randomly selected and approached. the purpose of the study was explained to them and their verbal consents were sought. a paper-pencil questionnaire was given to each respondent, the majority of the respondents completed the survey immediately (took approximately 15 minutes), a small number of the respondents were left with the questionnaire booklet and was collected after a mutually agreed period (at most after 24 hours). random sampling was used for convenience in the selection of organizations and respondents. in keeping with the research aim, the research team deliberately selected respondents from both genders and various age groups. a total of 732 people participated in this study. participants were drawn from several works of life in nigeria. participants were well distributed in terms of gender and age. as regards age, 21% (16-24), 19% (25-34), 17% (35-44), 13% (45-54), 13% (55-64), 11% (65-74), and 6%(above75). with regards to gender, 52% are males and 48% are females. 3.2. measurement instruments to determine participant’s personality traits we employed the 10 item personality traits (tipi) [55]. the tipi scale has been widely validated and used by many researchers including [56,57] for measuring the big five personality traits. the tipi scale consists of 10 items, two items measure each trait using a 7-point likert scale, ranging from 1= strongly disagree to 7=strongly agree. to determine participants’ subjective well-being, five prior validated scales nations, satisfaction with life, happiness, psychological, social and emotional well-being scales. the happiness scale developed by lyubomirsky and lepper [34] which consists of 4 items is a 5-point likert scale, personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi ranging from 1= very unhappy to 5 = very happy is used to elicits participants happiness. a sample item includes: “if you were to consider your life, in general, these days, how happy would you say you are?” the social well-being scale developed by huppert et al. [39] which consists of 14 items is a 5-point likert scale, ranging from 1= strongly disagree to 5 = strongly agree is used to measures participants social well-being. a sample item includes: “i gladly have contact with other people via social media (facebook, e-mail).”.” the satisfaction-with-life scale developed by diener et al. [31] which consists of 5 items is a 5-point likert scale, ranging from 1= strongly disagree to 5 = strongly agree is used to measured participants’ life satisfaction. a sample item includes: “if i could live my life over, i would change almost nothing.” the psychological wellbeing scale developed by diener et al. [42] which consists of 12 items is a 5-point likert scale, ranging from 1= strongly disagree to 5 = strongly agree is used to elicits participants psychological well-being. a sample item includes: “i am competent and capable in the activities that are important to me.” lastly, the emotional well-being scale developed by diener et al. [42] which consists of 16 items is a 5-point likert scale, ranging from 1= strongly disagree to 5 = strongly agree is used to measure participants emotional well-being. a sample item includes: “i have been dealing with problems well.” 3.3 procedure participants willingly volunteered to participate in this study, so no incentives were awarded to them. paper-pencil questionnaires were handed out to participants in their workplaces, which took approximately 15 minutes to complete. no identifying information was collected. the data collection was overseen by the federal university of dutse’s research ethics committee. 3.4. data analysis to analyze the data, we conducted structural equational modelling sem analysis using amos 20. specifically, we employed sem to develop a model showing how people of different personalities relate to various subjective well-being components. 3.5. validation of study instrument we conducted a confirmatory factor analysis (cfa) to test the validity of our study instruments and tested for the model fitness. we established the internal consistency of our constructs through their cronbach’s alpha (α) values. the results from the cfa show the cronbach alpha (α) for all constructs use to measure the personality traits to be between 0.75 and 0.83, all above the recommended threshold of 0.70. similarly, we established convergent validity from the values of the average variance extracted (ave). the results show the ave to be above 0.5 for all the scales of subjective well-being components. 4. results we conducted structural equation modelling (sem) to establish the relationship between the five personality traits and the individual components of the subjective well-being. in this section, we report results from our model. the goodness-of-fit indices shows that the hypothesized model was a good fit to the data; χ2 (10) = 10.334, the degree of freedom (df) = 4, p < .001, comparative fit personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi indices (cfi) = 0.987 (cfi > .90 is the recommended value) and root mean square error approximation (rmsea) = 0.033 (rmsea < .08 is the recommended value). χ2/ df = 2.583 (χ2/ df < 3 is the recommended value). the structural model the structural models determine the relations between the people’s personality traits and the individual components of the subjective well-being, figure 1. an important criterion to measure the strength of relationships between variables in structural models is to calculate the level of the path coefficient (β) and the significance of the path coefficient (p). path coefficients measure the influence of a variable on another. the individual path coefficients (β) and their corresponding level of significance (p) obtained from our models are summarized in table 1. figure 1: sem model structure table 1: path coefficient results personality traits subjective well-being components path coefficient (β) pwb ewb sowb swl h openness 0.14 0.17 0.21 0.32 conscientiousness 0.15 0.12 0.52 0.54 extraversion 0.18 0.27 0.53 0.43 0.47 agreeableness 0.21 0.16 0.11 0.15 0.13 neuroticism -0.44 -0.35 -0.23 -0.15 psychological well-being=pwb, emotional well-being=ewb, social well-being=sowb, satisfaction with life=swl, happiness=h. relationship between personality traits and subjective well-being. bolded coefficients are p<.001, non-bolded coefficients are p<.01, and ‘-’ represents non-significant coefficients. relationship between personality traits and subjective well-being. our results show personality traits to be strong predictors of subjective well-being components. we report how each component of the subjective well-being relates to the five personality traits. swb personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi happiness: our results show that happiness is significantly positively associated with all the personality types except for emotionally unstable people (neuroticism) who show no significant relationship: openness (β= 0.32, p<0.01), conscientiousness (β= 0.54, p<0.001), extraversion (β= 0.47, p<0.01), agreeableness (β= 0.13, p<0.01). this means that people who are high in openness, conscientiousness, extraversion, and agreeableness are more likely to harbor a higher level of happiness as a contributor to swb compared to those high in neuroticism. interestingly, conscientiousness has the strongest relationship with happiness. this finding is supported by barrick et al. [58] who found that conscientious employees achieved a higher volume of sales than their unconscientious co-workers. the feeling attached to achieving their goals makes them feel happier than their counterparts. thus, persuasive technological interventions aimed at increasing an individual’s well-being can target promoting their overall feeling of happiness as a way of fostering well-being. a plausible explanation of why happiness is not significantly associated with neuroticism is that people high in neuroticism due to their inherent characteristics of being emotionally unstable, are often stressed out and nervous. this makes them incapable of appreciating beauty and driving pleasure from simple things of life that make other people happy. satisfaction with life: our results show that satisfaction with life is positively associated with conscientiousness (β= 0.52, p<0.001), extraversion (β= 0.43, p<0.01), and agreeableness (β= 0.15, p<0.01). however, it is negatively associated with neuroticism (β= -0.15, p<0.01) and does not have a significant association with openness. these results mean that people who are high in conscientious, extraversion, agreeable personality traits are more likely to be more satisfied with life in general than people who are high in openness and neurotic personality. as expected, conscientiousness is most strongly positively associated with satisfaction with life. our findings are consistent with those of soto [46] who found that individuals high in conscientiousness tend to experience higher life satisfaction. this is expected because, conscientious people like to be very organized, often avoid making impulsive decisions and abide by rules. as a result, their lives often go as planned without hitches because they try to avoid doing things spontaneously which may consequently make them feel unsatisfied with their everyday affairs and lives generally. this is followed by extraversion, which is in line with ha et al [15] who also found that extraversion is positively associated with satisfaction with life among south koreans. on the other hand, satisfaction with life is negatively associated with people who are high in neuroticism. this finding is also consistent with those of soto [46] and chen [16] who revealed in their work that emotionally unstable individuals tend to experience lower life satisfaction. the association between satisfaction with life and openness is not significant while the positive association between satisfaction with life and agreeableness is weak. this implies that designing persuasive interventions to increase the satisfaction with life of people who are open to experience (openness), emotionally unstable (neuroticism) and cooperative (agreeableness) will increase their overall swb and hence impact positively on their overall health and well-being. emotional well-being: our results show that emotional well-being is positively associated with all the personality types except neuroticism: openness (β= 0.17, p<0.01), conscientiousness (β= 0.12, p<0.01), extraversion (β= 0.27, p<0.01), and agreeableness (β= 0.16, p<0.01). however, the positive association between emotional well-being and conscientiousness, openness and agreeableness is weak. emotional well-being is negatively associated with neuroticism (β= -0.35, p<0.001). this means that people who are high in extraversion are more likely to experience a personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi higher level of emotional well-being as a contributor to subjective well-being compared to other personality types. this means that designing persuasive interventions to increase the feeling of relaxation and stress freeness can greatly improve the swb and hence the overall health and wellbeing of people who are open to experience (openness), cooperative (agreeableness), goaloriented (conscientiousness) and neurotic people. social well-being: our results show that social well-being is positively associated with openness (β= 0.21, p<0.01), extraversion (β= 0.53, p<0.001), and agreeableness (β= 0.11, p<0.01). on the other hand, social well-being is negatively associated with neuroticism (β= -0.23, p<0.01) and is not significantly associated with people who are high in conscientiousness. extraversion emerged as the personality with the strongest positive associated with social well-being. this may be due to their inherent nature, extraversion tends to attach so much importance to having strong social networks, connecting and interacting with people. this is further supported by kendra [59] who describes extroverts as people who tend to feel isolated when they spend much time alone, hence, they tend to prefer to spend most of their time being around people. this is also supported by wido et al. [60] who found that extraverts participate in greater amounts of social activity compared to other people since they tend to enjoy it. the positive association between social well-being and agreeableness is weak. this means that people who are high in extraversion and openness are more likely to harbor a higher level of social well-being as a contributor to subjective well-being compared to those high in conscientiousness, neuroticism, and agreeableness. thus, designing persuasive interventions to increase the sense of belonging and social connectedness can greatly impact the sense of swb and hence overall health and well-being of goal-oriented people (conscientiousness), emotionally unstable (neuroticism) and cooperative (agreeableness). phycological well-being: our results show that psychological well-being is positively associated with all personality traits except neuroticism: openness (β= 0.14, p<0.01), conscientiousness (β= 0.15, p<0.01), and extraversion (β= 0.18, p<0.01), agreeableness (β= 0.21, p<0.01), and neuroticism (β= -0.44, p<0.01). the negative association of neuroticism with psychological wellbeing is expected since people high in neuroticism tend to experience strong negative affect more often than other personalities. the positive association between psychological well-being and openness, conscientiousness, and extraversion is quite weak. this means that people who are high in agreeableness are more likely to maintain a higher level of psychological well-being as a contributor to subjective well-being compared to those high in openness, conscientiousness, extraversion, and neuroticism. this implies that designing persuasive interventions to increase psychological well-being will greatly impact the sense of swb and hence overall health and wellbeing of people who are open to experience, agreeable, conscientiousness, and emotionally unstable (neuroticism). 5. discussion this study presents the results from investigating the relationship between personality traits and distinct components of subjective well-being in an african country where such a relationship has not been empirically confirmed. in this section, we discuss the results in relation to personality traits. personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi extraversion is a personality trait characterized by the tendency to associate with others and seek excitement. our findings show that extraversion is weakly positively associated with psychological well-being. this means that people high in extraversion do not involve themselves in activities that give them a high sense of psychological well-being. this implies that persuasive interventions designers targeted at promoting the overall health and well-being of people who are outgoing and enthusiastic can achieve that by designing their interventions to promote the psychological well-being component. this finding suggests that the overall health and well-being of people from african nations who are extroverted can be significantly improved if their psychological well-being is enhanced. therefore, we recommend that persuasive intervention designers targeted at promoting health and well-being among people who are outgoing and enthusiastic (high in extraversion) could focus on designing to enhance their psychological well-being to boost their swb and hence overall health. several techniques can be used in pt design to promote the psychological well-being of individuals. for example, feeling secure about the future, being hopeful, being positive, being enthusiastic have been shown to promote the sense of psychological well-being [36]. therefore, persuasive strategies such as reward and praise for small achievements have the power to evoke some feel-good emotions while self-monitoring and simulation that track and project the impact of an individual’s micro efforts towards achieving the desired behavioral change can raise the anticipation of positive results hence promote psychological well-being. conscientiousness is a personality trait that describes an individual’s tendency to be selfdisciplined, result-oriented, and goal-oriented. our findings show that conscientiousness is weakly positively associated with emotional well-being and psychological well-being and does not have a significant association with social well-being. this means that people high in conscientious tendencies harbor low emotional well-being, psychological well-being, and social well-being. one possible explanation of why social well-being is not significantly associated with conscientious people is that their goal-oriented and result-driven nature may make them too focused and unable to spare time to socialize with people around them. they are more likely to set strict goals and targets that make them conscious of how they spend their time, hence, they may not involve in social activities that are not an explicit part of their goals. this implies that persuasive intervention designers targeted at promoting overall health and well-being of people from african nations who are result-oriented and strict on following norms and rules to achieve their goals can achieve that by designing their interventions to promote these three components of subjective well-being. therefore, we suggest that persuasive technology designers aimed at promoting health and well-being among people high in conscious tendencies could focus on designing to promote their emotional well-being, psychological well-being and most especially the social well-being. several techniques can be used in pt design to create opportunities for an individual to interact and relate with others (social well-being). for example, persuasive techniques from the social support category of the persuasive system design (psd) framework [61] such as the social comparison, cooperation, and competition which provides opportunities for people to share and compare information about their behavior, interact and work together with other people, and personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi compete with others could be employed by designers to promote an individual’s sense of social well-being. similarly, some techniques can be used in pt design to promote emotional well-being. for example, activities that make people experience serenity, love, support, the company have been shown to promote people’s sense of emotional well-being [42]. consequently, persuasive strategies such as social facilitation, cooperation, and social learning could be implemented to provide opportunities for users to discern that other people are performing the behavior (along with them) and offer some social support could be employed by designers to promote emotional well-being and hence overall health and well-being of individuals. the strategies also give them the motivation and boost to continue the behavior change task, neuroticism is a personality trait characterized by the tendency to often be nervous, fearful, anxious or emotionally unstable. our findings show that people high in neuroticism tendency are negatively associated with emotional well-being, psychological well-being, satisfaction with life, and social well-being and do not have a significant association with happiness. this means that people high in neuroticism are usually not satisfaction with their lives, and experience negative social well-being, emotional well-being, and psychological well-being with very low happiness. a possible explanation of why satisfaction with life is negatively associated with people's high neuroticism is that due to their distrustful and pessimistic nature, they may find it hard to see the positives in most life situations and hence tend to be unsatisfied with life. another possible explanation is that people high in neuroticism may be too fearful to explore a variety of experiences that add meaning to life and therefore tend to limit themselves to a certain lifestyle that they may not be satisfied with. similarly, a possible explanation of why psychological well-being is negatively associated with people high in neuroticism is that they tend to be pessimistic and hence may find it hard to cope with anticipated negative results or outcomes. this feeling of insecurity or negativity may result in low psychological well-being. an explanation for this finding is well captured in the statement of ankrom [62] “that anxiety is a response to an unknown threat.” these findings are also in line with the study of chamberlain [28] who shows that neuroticism is negatively associated with mental health. a plausible explanation of why emotional well-being is negatively associated with people high in neuroticism is that due to their nervous and sensitive nature they are often vulnerable to anxiety [63]. again, social well-being is negatively associated with people high in neuroticism because due to their distressful and fearful nature, they often avoid or decline any opportunities to socialize and integrate with other community members. finally, a possible reason why happiness is not significantly associated with neuroticism is that due to their inherent characteristics of being emotionally unstable, they are often stressed out and nervous. this makes them incapable of appreciating beauty and driving pleasure from simple things of life that make other people happy. this means that persuasive interventions designers targeted at promoting overall health and well-being of people from african nations who are high in neuroticism can achieve that by designing their interventions to promote all the five components of subjective wellbeing. however, neuroticism is most strongly associated with emotional well-being and psychological well-being. this implies that the overall health and well-being of people from african nations who are high in neuroticism can be more promoted if activities that give them personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi more sense of emotional well-being and psychological well-being are enhanced. therefore, although designers aimed at designing persuasive intervention to promote health and wellbeing among people who are high in neuroticism could focus on designing to promote their satisfaction with life, happiness, and social well-being, they should focus more on designing to promote their emotional and psychological well-being which are the strongest determinants of their swb and hence their overall health and well-being. some techniques can be used in pt design to promote happiness. for example, activities and strategies such as expressing gratitude, acts of kindness, savoring, optimism, committing to one’s goals have been shown to promote people’s feeling of happiness [10] [64]. therefore, persuasive strategies such as rewards which give individuals credit for performing the target behavior and praise, in recognition of good behaviors can be employed by persuasive intervention designers to promote health and well-being. self-monitoring and simulation can also be used to enable the user to see the projected and accumulated benefits of their tiny efforts towards achieving the desired behaviors as a way of promoting happiness and hence overall health and well-being. likewise, some techniques can be used in pt design to promote satisfaction with life. for example, activities such as setting and achieving goals, attaining status, gaining respect, have been shown to promote people’s satisfaction with life [33] [65]. consequently, persuasive strategies such as goal setting which provides people with opportunities to set their goals and feedback which evaluates peoples’ performance and provides them with information about their progress and achievements could be employed to promote a sense of achievement and fulfillment for people. similarly, the recognition strategy which provides opportunities for people’s achievements to be publicly recognized could be employed by designers to make people experience feelings of pride and satisfaction with life and hence promote their swb and overall health and well-being. agreeableness is a personality trait characterized by the tendency to be kind, sympathetic and cooperative. our findings show that agreeableness is weakly positively associated with social well-being, emotional well-being, satisfaction with life, and happiness. surprisingly, this finding contradicts chen’s [16] work among taiwanese, in which he found that agreeableness is negatively associated with satisfaction with life. one possible explanation for this contradiction is the influence of cultural differences in the target audience, as explained by schimmack et al. [17] who found that the influence of personality on the cognitive component of subjective well-being is moderated by culture. these findings suggest that people high in agreeableness do not naturally engage in activities that give them a high sense of social well-being, emotional well-being, satisfaction with life and happiness and hence harbor less of these components of swb. this implies that persuasive intervention designers targeted at promoting the overall health and wellbeing of people from african nations, who are helpful, less competitive and friendly can target promoting these four components of subjective well-being. thus, we recommend that persuasive intervention designers aimed at promoting health and well-being among people who are high in agreeableness should focus on designing to promote their social well-being, emotional well-being, satisfaction with life, and happiness as a way of promoting their swb and hence overall health and well-being. personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi openness is a personality trait characterized by the tendency to be open to a variety of experiences. our findings show that openness is weakly positively associated with emotional well-being and psychological well-being and does not have a significant associated with satisfaction with life. a possible reason why the association between satisfaction with life and openness is not significant is that people who are high in openness tend to explore a variety of life experiences, therefore, they may be overwhelmed if their life does not measure up favorably against their standard. they are more interested in exploring different life experiences. interestingly, these findings contradict chen [16] who found a significant correlation between openness and satisfaction with life. as explained earlier, this contradiction could be due to cultural differences in the target audience. this means that persuasive intervention designers aimed at promoting the overall health and well-being of people from african nations who are open to experience can do so by targeting these three components of subjective well-being. therefore, although designers aimed at promoting health and well-being among people who are high in openness could focus on designing to promote their emotional well-being and psychological well-being, they should emphasize more on their satisfaction with life. persuasive strategies such as reward, praise, and recognition for micro-behaviors could be employed in persuasive interventions for promoting health and well-being to improve individuals’ satisfaction with life in line with positive reinforcement. in summary, our findings show that people high in extraversion are most strongly positively associated with all the five swb components. this means that in general, they experience a higher sense of swb compared to other personality types. on the other hand, people high in neuroticism are most strongly negatively associated with the swb components. this suggests that they harbor a low sense of swb when compared to other personality traits. hence pt designers should pay special attention to how to design to promote swb among people high in neuroticism. 6. limitations one limitation of this study is that we used self-report measurements to assess people’s personality traits and subjective well-being. although this is still the standard practice, we acknowledge that it may be biased 7. conclusion this paper presented the results of a large-scale study of 732 participants from a developing african country investigating the relationship between personality traits and distinct subjective well-being components. interestingly, our findings show that the relationship between personality traits and subjective well-being of africans (predominantly nigerians) are to some extent similar to those of other nations. consistent with other studies, our results show that there are statistically significant relationships between the big five personality traits (openness, conscientiousness, entravision, agreeableness, and neuroticism) and the distinct components of subjective wellbeing (happiness, satisfaction with life, psychological well-being, emotional well-being, and social well-being). specifically, our results show that people high in extraversion are weakly associated with psychological well-being. we also uncovered that people high in personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi conscientiousness are weakly positively associated with emotional well-being and psychological well-being and have no significant association with social well-being. our study also uncovered that people low in neuroticism are strongly negatively associated with emotional and psychological well-being. furthermore, our study revealed that openness is weakly positively associated with emotional well-being, psychological well-being, and does not have a significant associated with satisfaction with life. finally, we found that agreeableness is weakly positively associated with social well-being, emotional well-being, satisfaction with life and happiness. findings from this study imply that the interplay between personality traits and subjective wellbeing could play an important role in health informatics design. this study suggests that health informatics designers who seek to promote the health and well-being of individuals of different personality traits could target promoting specific components of the subjective well-being that an individual is weak on or negatively associated with. we suggest some design guidelines and persuasive strategies for promoting different subjective well-being components in persuasive intervention design depending on the target user’s personality. reference 1. fuhrer mj. 1994. subjective well-being: implications for medical rehabilitation outcomes and models of disablement. am. j. phys. med. rehabil. 73(5), 358-64. pubmed https://doi.org/10.1097/00002060-199409000-00010 2. pohlmeyer ae. 2013. “positive design: new challenges, opportunities, and responsibilities for design,” lect. notes comput. sci., vol. 8014 lncs, no. part 3, pp. 540–547. 3. dolan s. p., kudrna, and l., testoni, 2107. “definition and measures of subjective wellbeing,” cent. econ. perform., discussion paper 3, pp. 1–9. 4. diener e, et al. 2017. if, why, and when subjective well-being influences health, and future needed research. appl psychol health well-being. 9(2), 133-67. pubmed https://doi.org/10.1111/aphw.12090 5. diener e, chan my. 2011. happy people live longer: subjective well-being contributes to health and longevity. appl psychol health well-being. 3(1), 1-43. pubmed https://doi.org/10.1111/j.1758-0854.2010.01045.x 6. skaff mm, et al. 2009. daily negative mood affects fasting glucose in types 2 diabetes. health psychol. 28(3), 265-72. pubmed https://doi.org/10.1037/a0014429 7. black ph, garbutt ld. 2002. stress, inflammation and cardiovascular disease. j. psychosom res. 52(1), 1-23. pubmed https://doi.org/10.1016/s0022-3999(01)00302-6 8. kopp m, et al. 2003. life satisfaction and active coping style are important predictors of recovery from surgery. j psychosom res. 55, 371-77. pubmed https://doi.org/10.1016/s0022-3999(03)00012-6 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=7917167&dopt=abstract https://doi.org/10.1097/00002060-199409000-00010 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28707767&dopt=abstract https://doi.org/10.1111/aphw.12090 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26286968&dopt=abstract https://doi.org/10.1111/j.1758-0854.2010.01045.x https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19450031&dopt=abstract https://doi.org/10.1037/a0014429 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11801260&dopt=abstract https://doi.org/10.1016/s0022-3999(01)00302-6 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=14507549&dopt=abstract https://doi.org/10.1016/s0022-3999(03)00012-6 personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 9. r. veenhoven,2009. “how do we assess how happy we are? tenets, implications and tenability of three theories,” happiness, econ. polit. toward. a multi-disciplinary approach, october 2009, pp. 45–69. 10. lyubomirsky s. 2008.the how of happiness. london: penguin press. 11. choe ek, lee b. 2019. toward supporting personalized tracking experiences in healthcare. interaction. 27(1), 84-87. https://doi.org/10.1145/3371287 12. kelley c, lee b, wilcox l. self-tracking for mental wellness: understanding expert perspectives and student experiences. proc. chi ’17. acm, new york, 2017, 629–641. 13. choe ek, abdullah s, rabbi m, thomaz e, epstein da, et al. 2017. semi-automated tracking: a balanced approach for self-monitoring applications. ieee pervasive comput. 16(1), 74-84. https://doi.org/10.1109/mprv.2017.18 14. r. orji etal., 2018. “personalizing persuasive strategies in gameful systems to gamification user types,” proc. sigchi conf. hum. factors comput. syst. chi ’18, no. january. 15. ha se, kim s. 2013. personality and subjective well-being: evidence from south korea. soc indic res. 111(1), 341-59. https://doi.org/10.1007/s11205-012-0009-9 16. chen ls, ph d. 2008. subjective well-being. evidence from the different personality traits of online game teenager players. cyberpsychol behav. 11(5), 579-81. pubmed https://doi.org/10.1089/cpb.2007.0192 17. schimmack u, et al. 2002. culture, personality, and subjective well-being : integrating process models of life satisfaction. j pers soc psychol. 82(4), 582-93. pubmed https://doi.org/10.1037/0022-3514.82.4.582 18. matthews g, et al. 2009. personality traits., 3rd ed. new york: us: cambridge university press. 19. kendra c. “personality psychology.”. available: http:/www.verywellmind.com/personalitypsychology.[accessed: 24-jul-2018]. 20. bergmann n, et al. 2017.“understanding the influence of personality traits on gamification:the role of avatars in energy saving tasks,”in proceedings of the thirty eighth inter conference on information systems, pp. 1–12. 21. i. b. myers and m. h. mccaulley, 1985. “manual: a guide to the development and use of the myers-briggs type indicator.,” consult. psychol. press. 22. world p. “eysenck’s pen model of personality.” [online]. available: www.psychologistworld.com/personality/pen-model-personality-eysenck. [accessed: 14oct-2018]. https://doi.org/10.1145/3371287 https://doi.org/10.1109/mprv.2017.18 https://doi.org/10.1007/s11205-012-0009-9 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18771394&dopt=abstract https://doi.org/10.1089/cpb.2007.0192 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11999925&dopt=abstract https://doi.org/10.1037/0022-3514.82.4.582 personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 23. goldberg lr. 1993. the structure of phenotypic personality traits. am psychol. 48(1), 2634. pubmed https://doi.org/10.1037/0003-066x.48.1.26 24. gonzález gutiérrez jl, et al. 2005. personality and subjective well-being: big five correlates and demographic variables. pers individ dif. 38(7), 1561-69. https://doi.org/10.1016/j.paid.2004.09.015 25. thieme a, et al. 2015.“designing for mental wellbeing,” in proceedings of the 2015 british hci conference on british hci ’15, pp. 1–10. 26. brey pb. 2015. “design for the value of human well-being.,” in handbook of ethics, values, and technological design. sources, theory, values and application domains, pp. 365–382. 27. desmet pma, et al. 2013. special issue editorial: design for subjective well-being. int j des. 7(3), 1-3. 28. chamberlain k. 1988. the structure of subjective well-being. soc indic res. 20(6), 581604. https://doi.org/10.1007/bf03359559 29. stegeman m. 2014.“the relation between health and wellbeing,” university of twente. 30. petermans a, pohlmeyer a. 2014.“design for subjective well-being in interior architecture,” annu. archit. res. symp. vovember 2014 pp. 206–218. 31. diener e, et al. 1985. the satisfaction with life scale. j pers assess. 49, 71-75. pubmed https://doi.org/10.1207/s15327752jpa4901_13 32. prasoon r, chaturvedi kr. 2016. life satisfaction: a literature review. res. j. manag. humanit. soc. sci. 1(2), 1-32. 33. strine tw, et al. 2008. the associations between life satisfaction and health-related quality of life, chronic illness, and health behaviors among u.s. community-dwelling adults. j community health. 33(1), 40-50. pubmed https://doi.org/10.1007/s10900-007-9066-4 34. lyubomirsky s, lepper hs. 1999. a measure of subjective happiness: preliminary reliability and construct validation. soc indic res. 46, 137-55. https://doi.org/10.1023/a:1006824100041 35. lyubomirsky s, et al. 2005. the benefits of frequent positive affect: does happiness lead to success? psychol bull. 131, 803-55. pubmed https://doi.org/10.1037/00332909.131.6.803 36. compton wc. 2001. towards a tripartite factor structure of mental health: subjective welbeing, personal growth and religiosity. j psychol. 135(5), 486-500. pubmed https://doi.org/10.1080/00223980109603714 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=8427480&dopt=abstract https://doi.org/10.1037/0003-066x.48.1.26 https://doi.org/10.1016/j.paid.2004.09.015 https://doi.org/10.1007/bf03359559 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16367493&dopt=abstract https://doi.org/10.1207/s15327752jpa4901_13 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18080207&dopt=abstract https://doi.org/10.1007/s10900-007-9066-4 https://doi.org/10.1023/a:1006824100041 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16351326&dopt=abstract https://doi.org/10.1037/0033-2909.131.6.803 https://doi.org/10.1037/0033-2909.131.6.803 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11804003&dopt=abstract https://doi.org/10.1080/00223980109603714 personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 37. van dierendonck d, et al. 2008. ryff’s six-factor model of psychological well-being, a spanish exploration. soc indic res. 87(3), 473-79. https://doi.org/10.1007/s11205-0079174-7 38. harris m, martin m, martin d. 2006. the relationship between psychological well-being and perceived wellness in graduate-level counseling students. high. learn. res. commun. 34(4), 14-31. 39. h. fahuppert. et al., 2009.“measuring well-being across europe: description of the ess well-being module and preliminary findings,” soc. indic. res., vol. 91, pp. 301–315, 2009. 40. d. umberson and j. karas montez. 2010. social relationship and health: a flashpoint for health policy. j health soc behav. 51, s54-66. pubmed https://doi.org/10.1177/0022146510383501 41. barton h, grant m. 2006. a health map for the local human habitat. the journal of the royal society for the promotion of health. 126, 252-53. pubmed https://doi.org/10.1177/1466424006070466 42. diener e, robert b-d. 2008. happiness: unlocking the mysteries of psychological wealth. new york: wiley/blackwell. 43. pogosyan m. “positive emotions and well-being.” [online]. available: www.psychologytoday.com/us/blog/between-cultures/201611/positive-emotions-and wellbeing. [accessed: 24-oct-2018]. 44. brunner e. 1997. stress and the biological inequality. pubmed. 7092(314), 1472-75. 45. wilkinson r. 1996.“unhealthy societies: the affictions of inequality,” in london: routledge. 46. soto cj. 2015. is happiness good for your personality? concurrent and prospective relations of the big five with subjective well-being. j pers. 83(1), 45-55. pubmed https://doi.org/10.1111/jopy.12081 47. j. pers et al., “costa jr pt and mccrae rr, 2015. influence of extraversion influence of extraversion and neuroticism on subjective well-being : happy and unhappy people,” no. may 1980, pp. 668–678. 48. k. m. deneve and h. cooper, 1998.“the happy personality : a meta-analysis of 137 personality traits and subjective well-being,” vol. 124, no. 2, pp. 197–229. 49. librán ec. 2006. personality dimensions and subjective well-being. span j psychol. 9(1), 38-44. pubmed https://doi.org/10.1017/s1138741600005953 https://doi.org/10.1007/s11205-007-9174-7 https://doi.org/10.1007/s11205-007-9174-7 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20943583&dopt=abstract https://doi.org/10.1177/0022146510383501 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17152313&dopt=abstract https://doi.org/10.1177/1466424006070466 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=24299053&dopt=abstract https://doi.org/10.1111/jopy.12081 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16673621&dopt=abstract https://doi.org/10.1017/s1138741600005953 personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 50. friede a, blum hl, mcdonald m. 1995. public health informatics: how information age technology can strengthen public health. annu rev public health. 16, 239-52. pubmed https://doi.org/10.1146/annurev.pu.16.050195.001323 51. yasnoff wao, carroll pw, koo d, linkins rw, kilbourne em. 2000. public health informatics: improving and transforming public health in the information age. j public health manag pract. 6(6), 67-75. pubmed https://doi.org/10.1097/00124784-20000606000010 52. rooksby j, rost m, morrison a, chalmers m. 2014. personal tracking as lived informatics. in: chi 2014 32nd annual acm conference on human factors in computing systems, 26 april 1 may 2014, toronto, canada. 53. kawu aa, orji r, awal a, gana u. 2018. personality, culture and password behavior: a relationship study. in proceedings of 2nd africhi conference (windhoek,’18). acm, new york, ny, usa 54. maitland j, sherwood s, barkhuus l, anderson i, chalmers m, et al. increasing the awareness of moderate exercise with pervasive computing. proc perhealth 2006 55. gosling sd, et al. 2003. a very brief measure of the big-five personality domains. j res pers. 37(6), 504-28. https://doi.org/10.1016/s0092-6566(03)00046-1 56. orji r, et al. 2017 “towards personality-driven persuasive health games and gamified systems,” in proceedings of the 2017 chi conference on human factors in computing systems, chi ’17, 2017, pp. 1015–1027. 57. oyibo k, et al. 2017. investigation of the influence of personality traits on cialdini’s persuasive strategies. ceur workshop proc. 1833, 8-20. 58. barrick mr, et al. 1993. conscientiousness and performance of sales representatives: test of the mediating effects of goal setting. j appl psychol. 78(5), 715-22. https://doi.org/10.1037/0021-9010.78.5.715 59. kendra c. 2018.“personality traits of extroverts,” []online. available: www.verywellmind.com/signs-you-are-an-extrovert-2795426.[accessed 16-jun-2018]. 60. oerlemans wgm, arnold bb. 2014. why extraverts are happier: a day reconstruction study. j res pers. 50, 11-22. https://doi.org/10.1016/j.jrp.2014.02.001 61. oinas-kukkonen h, harjumaa m. 2009.“persuasive systems design : key issues, process model, and system features,” vol. 24, no. 1. 62. ankrom s. “the difference between fear and anxiety,” 2018. [online]. available: www.verywellmind.com/fear-and-anxiety-differences-and-similarities-2584399. [accessed: 03-jul-2018]. https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=7639873&dopt=abstract https://doi.org/10.1146/annurev.pu.16.050195.001323 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18019962&dopt=abstract https://doi.org/10.1097/00124784-200006060-00010 https://doi.org/10.1097/00124784-200006060-00010 https://doi.org/10.1016/s0092-6566(03)00046-1 https://doi.org/10.1037/0021-9010.78.5.715 https://doi.org/10.1016/j.jrp.2014.02.001 personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 63. hotchin k. “what’s the difference between nerves and anxiety?” 2017. available: www.healthblog.uofmhealth.org/health-management/whats-difference-between-nerves-andanxiety. [accessed: 02-sep-2018]. 64. seligman mep. 2011. flourish: a visionary new understanding of happiness and wellbeing. new york: us: free press. 65. j. r. bringle, 2003.“factors contributing to life satisfaction in early and middle adulthood : a 34-year follow-up.,” masters theses 1911, feb. 2014. 66. psychologistworld. “consceintiousness: a ‘big five’ personality traits.” [online]. available: http/www.psychologistworld.com/influence-pesonalit/conscientiousnesspersonality-traits. [accessed: 16-jun-2018]. appendix: personality traits and subjective well-being measurement instrument personality traits on a scale of 1 to 5(1= strongly disagree to 5 = strongly agree), to what extent do you agree with the following statements. i see myself as someone who: 1. is reserved. 2. is generally trusting. 3. tends to be lazy. 4. is relaxed, handles stress well. 5. has few artistic interests. 6. is outgoing, sociable. 7. tends to find fault with others. 8. does a thorough job. 9. gets nervous easily. 10. has an active imagination. happiness scale on a scale of 1 to 5 (1= very unhappy to 5 = very happy), please circle one number that corresponds to your response to each question. 1. if you were to consider your life, in general, these days, how happy or unhappy would you say you are? 2. compared to most of your peers, you consider yourself? 3. some people are generally happy. they enjoy life regardless of what is going on, getting the most out of everything. to what extent does this characteristic describe you? personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 4. some people are generally not happy, although they are not depressed, they never seem as happy as they might be. to what extent does this characteristic describe you? 5. please, list things that make you happy (you can list up to 10) 6. please, list things that make you unhappy (you can list up to 10) satisfaction with life scale on a scale of 1 to 5 (1= strongly disagree to 5 = strongly agree), to what extent do you agree with the following statements. 1. in most ways, my life is close to my ideal 2. the conditions of my life are excellent. 3. i am satisfied with my life 4. so far, i have gotten the important things i want in life. 5. if i could live my life over, i would change almost nothing. 6. all things considered, i am satisfied with my life these days. 7. please, list things that give you satisfaction in life (you can list up to 10 things): 8. please, list things that make you unsatisfied with life (you can list up to 10 things): social well-being scale 1. i have close contact with my direct neighbors 2. i think it's important to be a member of an association 3. i'm content with my social position 4. i'm content with the relation to my neighbours 5. people in my neighbourhood handle each other in a positive manner. 6. i see myself as a part of society 7. i gladly have contact with other people via social media (facebook, e-mail) 8. there are enough people with who i feel strongly connected 9. i gladly help other people if they need my help 10. i'm content with the composition of the population in my neighbourhood. 11. i feel accepted in my neighbourhood 12. i trust in the people in my surrounding 13. i gladly participate in activities in my neighborhood 14. my work situation contributes to my well-being. 15. i gladly spent time with online gaming with other people 16. i'm content with my surroundings. psychological well-being scale 1. i lead a purposeful and meaningful life. 2. i am engaged and interested in my daily activities. 3. i am competent and capable in the activities that are important to me. 4. i am a good person and live a good life. 5. my material life (income, housing, etc.) is sufficient for my need 6. i am satisfied with my religious or spiritual life. 7. i am optimistic about the future. personality and subjective well-being: towards personalized persuasive interventions for health and well-being. online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 12(1):e1, 2020 ojphi 8. i have no addictions, such as to alcohol, illicit drugs, or gambling 9. people respect me. 10. i have been feeling optimistic about the future. 11. i actively contribute to the happiness and well-being of others. 12. i generally trust others and feel part of my community emotional well-being scale 1. i have been feeling useful. 2. i have been dealing with problems well. 3. i have been thinking clearly. 4. i have been feeling close to other people. 5. i have been feeling confident. 6. my social relationships are supportive and rewarding 7. i have been interested in new things. 8. i have not been feeling depressed. 9. i have not been feeling sad. 10. i have not been feeling afraid. 11. i have been feeling contented. 12. i have been feeling positive. 13. i have been feeling joyful. 14. i have been feeling cheerful. 15. i have been able to make up my mind about things. 16. i have been feeling loved vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi vincent: a visual analytics system for investigating the online vaccine debate anton ninkov1*, kamran sedig1 1. insight lab, western university, canada abstract this paper reports and describes vincent, a visual analytics system that is designed to help public health stakeholders (i.e., users) make sense of data from websites involved in the online debate about vaccines. vincent allows users to explore visualizations of data from a group of 37 vaccine-focused websites. these websites differ in their position on vaccines, topics of focus about vaccines, geographic location, and sentiment towards the efficacy and morality of vaccines, specific and general ones. by integrating webometrics, natural language processing of website text, data visualization, and human-data interaction, vincent helps users explore complex data that would be difficult to understand, and, if at all possible, to analyze without the aid of computational tools. the objectives of this paper are to explore a) the feasibility of developing a visual analytics system that integrates webometrics, natural language processing of website text, data visualization, and human-data interaction in a seamless manner; b) how a visual analytics system can help with the investigation of the online vaccine debate; and c) what needs to be taken into consideration when developing such a system. this paper demonstrates that visual analytics systems can integrate different computational techniques; that such systems can help with the exploration of online public health debates that are distributed across a set of websites; and that care should go into the design of the different components of such systems. keywords: visual analytics, public health, vaccine debate, webometrics, natural language processing, data visualization, human-data interaction abbreviations: visual analytics system (vas), multi-dimensional scaling (mds), natural language processing (nlp), natural language understanding (nlu), vincent (visual analytics system for investigating the online vaccine debate) *correspondence: anton ninkovaninkov@uwo.ca doi: 10.5210/ojphi.v11i2.10114 copyright ©2019 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in t he copy and the copy is used for educational, not-for-profit purposes. 1. introduction as the use of the internet expands, people engage in social discourse and debate in different areas of interest, generating a great deal of online data. one broad area of interest generating vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi such online information is public health. public health data is often large, complex, and difficult, if at all possible, to analyze without the aid of computational tools. public health informatics is a research area that focuses on “the systematic application of information, computer science, and technology to public health practice, research, and learning” [1]. visual analytics systems (vases) can be of great utility in public health informatics [2]. vases are computational tools that combine data visualization, human-data interaction, and data analytics. they allow users to interactively control data visualizations to change how data is analyzed and presented to them. vases make it possible for users to quickly make sense of online data that would otherwise be impossible or take more time and effort to accomplish. in this paper, we report and describe a vas designed to help public health stakeholders (users) make sense of data from websites involved in the online debate about vaccines. the vas, vincent (visual analytics system for investigating the online vaccine debate), allows users to explore visualizations of data from a group of 37 vaccine-focused websites (listed in appendix 1). these websites range in their position on vaccines, topics of focus about vaccines, geographic location, and sentiment towards the efficacy and morality of vaccines, specific and general ones. while numerous vases have been developed and studied previously, vincent is novel in that it integrates webometrics (i.e., co-link analysis), natural language processing (i.e., text-based emotion analysis), data visualization, and human-data interaction. the research questions this paper examines are as follows: 1. is it feasible to integrate webometrics, natural language processing of website text, data visualization, and human-data interaction in a seamless manner to develop a vas? 2. can such a vas help with the investigation of the online vaccine debate? 3. what are some of the considerations that need to go into developing such a system? the remainder of this paper is organized as follows. section 2 provides a conceptual and terminological background--i.e. vaccine debate, visual analytics systems, webometrics, and natural language processing. section 3 describes the development of vincent and includes an in-depth discussion of the various components of the vas. section 4 provides a summary and conclusions. 2. background this section provides a conceptual and terminological background for this paper. we will first describe the issue that vincent aims to clarify--i.e. the vaccine debate. next, we will review visual analytics. finally, we will discuss the data analytics methods (webometrics and natural language processing) that are used in this research. 2.1 vaccine debate in light of increased recent news coverage of outbreaks of diseases such as measles and whooping cough, the anti-vaccination movement appears to be a new and emerging phenomenon vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi [3-5]. the world health organization has listed the rise of the anti-vaccination campaign as a top ten health emergency in 2019 [6]. however, anti-vaccination views and sentiments are not a recent development. since edward jenner’s discovery of the smallpox vaccine, vaccination has garnered much attention both positive and negative. from the beginning, some have felt that the practice of vaccination is ineffective, violates personal freedoms, and is “unchristian” [7]. however, the centers for disease control reports that vaccines have had a positive impact on global health and are “one of the greatest achievements of biomedical science and public health” [8]. despite the medical community’s unified support of immunization, there are many reasons for the persistence of anti-vaccine views. there is some suggestion that increasingly polarized political views (especially in the united states) have generated an environment in which the rejection of scientific facts has become more prevalent and accepted [9]. this erosion of trust in scientific findings among segments of the population may also contribute to this increased polarization. additionally, the rise in accessibility to, and widespread use of, the internet has played a role in amplifying the voice of the anti-vaccination movement [10,11]. [11] states, “the connective power of the internet brings together those previously considered on the fringe. members of marginalized groups (e.g. holocaust deniers, 9/11 'truthers', aids deniers) can easily and uncritically interact with like-minded individuals online… anti vaccine groups have harnessed postmodern ideologies and by combining them with web 2.0 and social media, are able to effectively spread their messages”. hence, the internet plays an important role in the antivaccination movement, helping spread their message and promoting their views on vaccination dangers. the polarity of the vaccine debate is creating a clear divide and this has been revealed through both qualitative classification of inlinks [12] and quantitative co-link analysis [13]. the divide is having harmful effects on the health of the general population. “providers and policymakers must begin to recognize the jagged, context-dependent, equifinal nature of how parents sort through vaccination-related information or account for their vaccination decisions in order to reverse declining vaccination rates” [14]. some of the themes of the discussion that have developed in this polarized debate include those related to autism and vaccines, evil government conspiracies, and technological developments [15]. a more automated approach that would allow an analysis of such online discussions and information could help illuminate this public health problem. 2.2 visual analytics systems (vases) in today's environment of big data, people are often victims of information overload. they can get lost in and overwhelmed by the voluminous data and its meaning that they encounter [16]. by combining human insight with powerful data analytics and integrated data visualizations and human-data interaction, vases can help alleviate this problem. vases can enable potential stakeholders to make sense of data. “just like the microscope, invented many centuries ago, allowed people to view and measure matter like never before, (visual) analytics is the modern equivalent to the microscope” [17]. vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi vases are composed of three integrated components: an analytics engine, data visualizations, and human-data interactions [18,19]. the analytics engine pre-processes and stores data (e.g., data cleaning & fusion), transforms it (e.g., normalization), and analyzes it (e.g., multidimensional scaling, emotion analysis) [20]. examples of data analytics techniques that can be integrated into the analytics engine are webometrics and natural language processing (nlp). data visualizations in a vas can be visual representations of the information derived from the analytics engine. visualizations extend the capabilities of individuals to complete tasks by allowing them to analyze data in ways that would be difficult or impossible to do otherwise [19,21]. for instance, a scatterplot can be used to visually represent coordinates of entities, and this, in turn, helps the user determine quickly the proximity between data points. human-data interaction is used in vases to allow the user to control the data they see and the way the data is processed. interaction in vases supports users through distributing the workload between the user and the system during their exploration and analysis of the data [18,22,23]. some examples of the numerous human-data interactions that can be incorporated into vases include filtering, scoping, and drilling of data [24], with each interaction supporting different epistemic actions on information by the user. one of the theories that can help with the conceptualization of vases is general systems theory. systems theory views a system as composed of entities, properties, and relationships [25]. vases are complex, multi-level systems, consisting of systems within systems [18]. these multi-level systems consist of super-systems, systems made up of other systems, and subsystems, together making up a super-system [25]. with this understanding of systems theory, we can see how vases work. when building and examining vases, the interactions of the user with the system can have an impact on any of these levels. at the highest level, super-system interactions will change the overall display of the vas. at lower levels, the interaction subsystem will change specific components of the system. these interactions, regardless of level, are important to the functioning of the vas and necessary for making sense of the data being presented. there are several resources available to assist in developing vases. two of the most widely used vas resources include the open source d3.js javascript library [26] and tableau software [27]. the advantage of d3.js is the almost limitless customization capabilities it offers, as it is bound only by programming constraints, and the fact that it is open source. however, the time, effort, and programming skills required by developers to create systems is greater for d3.js than other solutions, as there are fewer templates and starting points to work with. tableau, on the other hand, is a proprietary data visualization software that provides users with the ability to develop interactive data visualizations with only minimal coding effort. one feature that makes tableau particularly appealing is that there are several templates available to users to build their own interactive visualizations. as well, tableau allows users to create dashboards easily, which place multiple interactive visualizations together in one system that automatically connects data together. while both d3.js and tableau can be useful solutions for developing visual analytics, tableau has been used in this research because of its ability to create a functioning and useful visual analytics system while at the same time reducing the programming workload. vases incorporate one or more data analysis techniques including (but not limited to) supervised learning (i.e. decision trees or svm), or cluster analysis [16]. previous vas research vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi has incorporated similar data analysis techniques used in vincent. for example, researchers have investigated how incorporating multi-dimensional scaling of co-occurrence data (discussed in section 2.3) in vases help users investigate entities and identify clusters in a variety of data sets [28,29]. as well, researchers have utilized emotion analysis (discussed in section 2.4) in vases that help users investigate online text from both social media and the general web regarding a variety of topics [30-32]. both these data analysis techniques have been implemented in vas research independently of each other, however there have been no published studies examining the integration of the two techniques in a single vas, as proposed in vincent. 2.3 webometrics webometrics is the “quantitative study of web-related phenomena” [33]. with the everincreasing adoption of the internet, the various metrics used for analyzing its data, such as hyperlinks, become important to investigate. two types of webometrics research methods exist: evaluative and relational [34,35]. evaluative webometrics can include examining webpages for properties such as (but not limited to) the number of external inlinks they receive (links directed to a website from another website) and the website location [12,35,36]. examining the number of inlinks a website receives has been shown to be an indicator of performance in a variety of measures for organizations [33,3739]. additionally, geographic location has demonstrated to be a valuable resource in conducting evaluative webometrics research [40,41]. relational webometrics focuses on “providing an overview of the relationships between different actors” [35]. co-occurrence measurements to indicate similarity are important for relational analysis in webometrics [35,36,42]. the concept behind this method is that the more entities share occurrences, the more likely they are to be similar in some way [34]. this method can apply to webometrics in the study of co-links to help analyze similarity in terms of shared online presence between websites [41,43-45]. to represent and examine co-link data, numerous studies have been conducted with multi-dimensional scaling (mds)--studies using mds to analyze business [45], university [46], government [47], and political domains [48,49]. all these studies found that using mds to analyze co-links generated worthwhile insights into the data. 2.4 natural language processing (nlp) nlp is a vast area of research that focuses on using computational methods to understand and produce human language content [50]. nlp encompasses a wide range of research topics, two of which are text-based emotion detection and word frequency [51]. text-based emotion detection has been examined previously in nlp research [51-54]. one resource, in particular, that has been developed that makes it possible for researchers to automatically conduct this type of analysis is ibm’s natural language understanding (nlu) api [55]. the nlu api (formerly referred to as the alchemyapi) has been widely used by many researchers to study topics, sentiments, and emotions in text [56-59]. the nlu api allows researchers to either input text directly or pull text from urls of webpages and return a number of different nlp analyses, one of which is emotion analysis. furthermore, the nlu api can not vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi only detect emotion on the entirety of a text/webpage, but can also return emotion scores for specified target words/phrases [55]. the study of word frequency in text has been examined and used in nlp research [60-62]. one of the main concerns for word frequency analysis is how to manage meaningless or unimportant words. in english, like any language, there are many words that are repeated frequently that are not necessarily the key point of interest to a reader. some of the more obvious examples of these words are “the”, “and”, and “of”. other types of undesirable words can exist depending on the domain of interest (e.g., dates or numbers). to deal with this issue, the technique of filtering for a list of stop words has been used, and preliminary lists of these words have been created that allow researchers to automatically exclude words that are not of interest [63]. to display word frequency data, word clouds have been used successfully [60-62]. word clouds display identified words in varying sizes, with larger words being the more frequent. word clouds are useful because they allow users to quickly see the most prevalent words of a text document and enable them to make quick assessments about what the overall text of a document/website may be discussing. 3. system design the design of vincent, displayed in figure 1, consists of three primary components: the analytics engine, data visualizations, and human-data interactions. in this section, we will discuss these components of the system and explain how the data was collected and managed. vincent was developed in tableau, version 10.5. figure 1: vincent: a visual analytic system vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi 3.1 analytics engine the analytics engine of vincent utilizes webometrics and nlp as its data analysis methods. in this section, we will discuss how, using these methods, data was collected, transformed, and processed. for webometrics, this included leveraging inlink data and geographic location data. for nlp, this included leveraging word frequencies and emotion detection analysis. the list of 37 vaccine websites (appendix 1) in vincent was created based on a list produced for a study on co-link analysis of vaccine websites which included a total of 62 websites [13]. websites from that study could be included in vincent if they had a central focus on the vaccine debate and a minimum of 200 inlinking domains. the reduction from the original list was primarily due to the elimination of website that were more minor, websites that had increased their scope beyond just vaccination, and websites that had gone obsolete or merged with another website to form a new website. this list should not be viewed as comprehensive of all vaccine websites, but rather as a sample of some of the more major english-based ones from both sides of the polarized debate. 3.1.2 webometrics inlink data was collected from each website using moz’s link explorer tool (https://www.moz.com/link-explorer). diverging from some of the previous webometrics research using inlink data, which mostly investigated inlinks coming from pages (41,43–45) and sites (13), vincent uses inlink data about the inlinking domains. changes in september 2018 to the data provided by moz required us to adapt and examine the feasibility of using domainlevel inlink data. after comparing domain-level inlink data to data collected for a previous study (13), we determined that the domain-level inlink data was a suitable replacement and would be used in the analytics engine of vincent. the shared online presence between the set of websites (appendix 1) was analyzed using mds. following similar data analysis techniques to that of previous mds research [13], the inlink data collected on each website was used to create a similarity matrix, which is based on the number of co-links each website shared with one another. using a computer program originally developed for a previous study [13], this co-link data was generated from the collected raw data. using the output co-link matrix, the data was input into spss version 25 and an mds analysis was conducted. the results of this analysis provided a scatter plot in which each data point was plotted according to the number of co-links they shared, or in other words their shared online presence. websites that shared more inlinks (and therefore more online presence) were more similar and plotted closer together, while those with fewer inlinks were plotted further away from each other. the goodness of fit between the output scatter plot and the co-link matrix had a stress value of less than 0.05, which suggests a good fit between the two. data was also collected regarding the geographic location of the websites. this data was collected through two primary means. the first way of collecting location data was through the sites themselves. many of the websites had identifying information about the managing owner or organization. the data usually came from an “about us” or “contact us” page and required manual labor to find. for those that did not indicate on their website a location, icann whois vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi registration data was collected. for each of the various collected locations, latitude and longitude coordinates were generated to plot each website on the map of website locations. 3.1.2 nlp word frequency data was collected using the following process. first, each website was analyzed and crawled using insite5, a software package developed by inspyder (https://www.inspyder.com/products/insite). with this software, we were able to obtain a csv export file containing a list of all the words contained on each website, along with the frequency of those word occurrences. after collecting all the raw data about each website, the word frequency lists were filtered to meet the requirements of our analysis. in other words, we wanted only unique words related to the vaccine debate to be displayed. in this effort, we manually created a stop words list to remove irrelevant or common words. the list was built, first, using the natural language toolkit list of stop words for english [63]. this list of stop words contains some of the most common english words (e.g., “i”, “you”, “too”). from this starting point, the list was expanded to include words that needed to be removed including, but not limited to, letters (e.g., “a”, “b”), dates (e.g., “january”, “wednesday”), self-reference names (e.g., “nvic”, “voices for vaccines”), people’s names (e.g., “tom”, “katie”), internet words (e.g., “blog”, “post”), and common vaccine debate words (e.g., “vaccines”, “vaccination”). in total, the stop words list, used to refine the word frequency data, consists of 1231 words. after finalizing each of the website’s individual word frequency list, combined word frequency lists were created for 3 sets of websites: all websites, anti-vaccine websites, and pro-vaccine websites. for each word, the sum of the word frequency was normalized by sum of the total number of words in that set. this generated a proportional count of each word’s presence on the website for each website’s top 25 words. this was a more accurate reflection of the presence of the word on the site rather than simply counting the word frequency totals as some sites had more total words than others. with these proportional word frequencies generated, a list of top 25 words for the 3 sets of websites was also created: all websites, anti-vaccine websites, and provaccine websites. text-based emotion detection in the website was conducted with the use of ibm’s nlu tool. this tool provides nlp automation through the use of their api and, specifically, can do targeted phrase emotion detection. a user can input text or a url of a webpage of interest and specify target phrases of interest. the nlu api will return scores for the level of emotion detected for those phrases. five different emotions (joy, fear, anger, sadness, and disgust) are provided for analysis, which is an overrepresentation of negative emotions [64]. for this system, we did not want to bias our data by over-representing negative emotions. consequently, the data was cleaned up by merging the 4 negative emotions into one and the labels were changed to reflect a binary of positive emotion (joy) and negative emotion (fear, anger, sadness, and disgust). the vaccines of interest that were examined included: flu, mmr, measles, chicken pox, whooping cough, hpv, polio, hepatitis b, and meningitis. the text was processed using the nlu api’s targeted emotion analysis tool. for each of the vaccines, we manually sampled 2 webpages that contained meaningful discussion about the specified vaccine. several alternate ways of referencing the vaccines were all targeted. for example, with the mmr, targeted phrases included “mmr”, “mmr vaccines”, and “mmr vaccination”, among others. the data from vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi each of these different phrases for a vaccine were then merged to reflect the total emotion detected about the specified vaccine. 3.2 data visualizations vincent is comprised of four main visualization components: an online presence map, a word cloud, a map of website locations, and an emotion bar chart. each of these visualizations represents an important aspect of the websites' information and involves some type of webometrics or nlp data analytics. in this section, each of these visualizations will be discussed, looking at the decisions that were made to represent the data. 3.2.1 online presence map the online presence map, displayed in figure 2, is a representation of the hyperlink data analyzed from each website. the generated mds scatter plot map of the websites displays each website in proximity to each other based on their shared online presence. websites that are plotted closer together share more online presence, while those plotted further away share fewer. based on this map, polarity between the antiand pro-vaccine websites was evident, similar to findings in previous related research [13]. all anti-vaccine websites ended up on the left side of the map, while all pro-vaccine websites are located on the right side with a space in the middle dividing the two. to display the existence of this polarity, a line dividing the two groups of websites was added to the map with labels for the anti-vaccine and pro-vaccine sides. online presence for each website was encoded as a circle representing each of the websites. in this representation, each of the circles was sized based on their total number of inlinking domains. the larger a circle, the more inlinks and, therefore, the larger online presence it has. for reference, the site with the most inlinking domains (9,986) is immunize.org, while the site with the fewest inlinking domains (248) is vaccine injury help center. vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi figure 2: mds similarity map 3.2.2 word cloud the word cloud, displayed in figure 3, is a representation of the 25 most common unique words that are related to the vaccine debate from each website or group of websites. words are sized based on the frequency with which they appeared on the website or group of websites. the bigger a word is on the word cloud, the more frequently it is used on the website, while the smaller a word is, the less frequently it is used. each word was colored differently to assist with differentiating words from each other. vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi figure 3: word cloud for all websites 3.2.3 map of website locations the map of website locations, displayed in figure 4, shows a representation of the locations of each website on a world map. website location is an important piece of data as it allows users of the system to explore the geographic diversity of the websites and identify where clusters of websites may exist. similar to the online presence map, the website locations use circles to encode each website. different from the online presence map, the circles were all sized equally to help the user see the location of each website, and to avoid confusion with excessive overlapping and occlusion of the circles. vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi figure 4: map of website locations 3.2.4 emotion bar chart the emotion bar chart, displayed in figure 5, represents positive and negative emotions for a selection of each website's text about a set of vaccines. the two bar charts represent the negative (red) and positive (green) emotions detected by the api. each bar is composed of individual rectangles that refer to individual websites in the set studied. the width of each of these individual rectangles represents the degree of detected emotion on that specific website. the wider the rectangle, the more that emotion is detected. the entire bar is made up of all the smaller rectangles (websites). this bar then represents the overall detected emotion in the text of the complete website set. the negative and positive bar charts will change in response to the data set that is selected. this will be discussed in more detail in section 3.3.2. figure 5: emotion bar chart vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi 3.3 human-data interactions to support users to gain insight into the data and explore the online vaccine debate, many interactions are built into vincent. these interactions take place on a global level as well as in the sub-systems of vincent. in this section we will explore these interactions and discuss how they will assist users to explore the data. 3.3.1 global system interactions there are several interactions that users can perform on vincent that occur at the global system level. these interactions not only affect displayed data at individual, sub-system levels of vincent, but also change displayed data at the level of the whole system. global system interactions in vincent include website selection and filtering of websites. the website selection interaction allows users to focus on a single website. using this interaction (see figure 6), users can highlight a single website’s data throughout the system in order to determine quickly the website’s position on vaccination, online presence, location in the world, and emotion about specific vaccines. consider the following use case. a user is interested in learning more about the website “sanevax”. they would select this website (figure 6) from the existing options. vincent would then highlight the data points associated with this website, as displayed in figure 7. for this selected website, the user can immediately find that the website's position is anti-vaccine, that it has strong online presence, that it is located in north western part of north america, that it has more negative emotions regarding vaccines than positive, and that it discusses many issues related to hpv (i.e., cervarix, gardasil, cancer, silgard, hpv). figure 6: website selection interaction vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi figure 7: vincent after website selection interaction in addition to the website selection interaction, users have the ability to filter the data to focus on a selected group of websites. users can highlight and select websites using any of the 3 visualizations, thereby filtering and isolating the data points of a subset of websites. this can be done using the online presence map, map of website locations, or emotion bar chart. consider a sample use case. a user is curious to learn more about the websites located in north eastern part of north america. the user goes to the map of website locations and picks websites located in that geographic region. in reaction, the data points on the online presence map and the data of the emotion bar charts are filtered to show only these data points, as displayed in figure 8. simultaneously, the stat tracker on the bottom right changes to give the user a numeric count of how many websites they are utilizing now, and how many of each vaccine position is included. the user will quickly see that they have selected 15 websites (10 pro-vaccine and 5 anti-vaccine websites), that the websites are wide ranging in shared online presence, and that they have approximately equal degree of positive and negative emotions associated with the vaccines. vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi figure 8: global filtered selection (north eastern north america) 3.3.2 sub-system interactions there are a number of interactions that can be performed at the sub-systems level of vincent. these interactions are focused on isolated elements of the system. they include such interactions as filtering the emotion bar chart to display selected vaccines, hovering display elements to expand an information box, and navigating the map of website locations. the vaccine selection interaction allows users to filter the displayed data on the emotion bar chart. upon opening vincent, the emotion bar chart displays the overall vaccine emotion data. when a user selects a specific vaccine, the bar chart changes to display only the emotion data that is collected about that specific vaccine. consider a sample use case. a user is curious about the emotions of the entire set of websites regarding the mmr vaccine. the user would select this vaccine (see right-hand panel in figure 9), and the bar charts change to display the data. the user can immediately see that there is a greater level of negative emotion on the set of websites than positive emotion regarding the mmr vaccine. figure 9: filtered vaccine selection (mmr) vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi users also have the option to hover over the online presence map, map of website locations, or emotion bar charts to expand an information box (this is referred to in tableau as a tooltip) about each specific data point. when a user hovers off the data point, the information box disappears. again, a sample use case is illustrative of this. a user is interested in identifying which of the pro-vaccine websites have the greatest online presence. to do this, the user would examine the online presence map, determine which token on the pro-vaccine side of the map is the largest, and hover the mouse icon over the token to reveal the information (see figure 10). in this case, it would be “immunization action coalition”. similarly, if the user were interested in knowing more about a website at a specific location or emotion score, they would hover over those data points to reveal that information. figure 10: hover to expand information box finally, on the map of website locations, users have the ability to navigate through the set of websites. on the map of website locations, users can zoom in and out of the map to focus on specific areas. as well, users can click on and drag over the map to move the area of focus. consider a sample use case. a user is interested in looking at websites in europe to get a better sense of where exactly they are located. by zooming in on the map and going to europe (as seen figure 11), they can clearly identify four websites located there in england, germany, belgium, and switzerland. vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi figure 11: navigate map of website locations 4. summary and conclusions in this paper, we have reported the development of vincent, a vas to help with the investigation of data from websites involved in the online debate on vaccination. vincent was created using tableau, version 10.5. vincent incorporates three main sub-systems, each comprised of other sub-systems. an analytics engine made up of webometric (co-link analysis) and nlp (text-based emotion detection) data analysis components; visualization, made up of several different data visualizations; and interaction, made up of a set of different human-data interactions. the development of vincent demonstrates that it is feasible to integrate webometrics, natural language processing of website text, data visualization, and human-data interaction into a vas. vincent is novel in its incorporation and integration of the data analysis techniques used (i.e. co-link analysis and text-based emotion analysis) with data visualization and human-data interaction, which had never been previously attempted. vincent supports user exploration of data derived from a set of 37 vaccine websites and enables the user to investigate and develop an overall perspective on the vaccine debate. by looking at data from individual websites and groups of websites, a user can identify the breakdown of proand anti-vaccine websites, the emotions contained within these websites about specific vaccines, the locations of these websites, and the frequency of vaccine words that appear in these websites. furthermore, by integrating the data from these different websites, users can associate the various types of data and uncover patterns that would be otherwise difficult to identify. several considerations should go into creating vases such as vincent. first, deciding which tool to use to create the vas is important. there are advantages and disadvantages to using more programming intensive solutions (such as d3.js) versus more rigid, yet easier to use, toolkitbased solutions (such as tableau). as well, identifying the appropriate data sources is a challenge that is unique to each project. online data sources are constantly changing; therefore, it is important for researchers to keep abreast of the current available data. depending on the resources available to the developer, alternate methods and sources for acquiring proprietary data could improve the value of the system. next, determining which visualizations are most vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi appropriate for each type of studied dataset is important. for example, the emotion bar charts, presented here, went through several iterations. at first, tree maps were tested but were found to be inadequate at representing certain aspects of the data. researchers who develop similar vases need to consider all facets of their data and desired interactions and test various iterations of their system. finally, incorporating meaningful interactions into the vas is important. it is necessary to analyze the tasks that users would need to perform, and then determine what combinations of interactions would facilitate the performance of these tasks. in the case of vincent, such tasks included comparing websites, identifying groups of websites, and identifying trends in the entire set of websites. vincent was developed to help users make sense of the data from vaccine websites and, ultimately, the online vaccine debate. however, there are many other areas, both within and outside of public health, for which a system such as this could also prove useful. in public health, a similar vas would be useful for surveillance of other online health debates, such as debates on the efficacy of alternate health claims or debates regarding different medications and drugs. outside of public health a system similar to vincent could prove beneficial in the areas of business, academia, or politics. one example of such an area that would be well served by a similar vas is the online discussion about cannabis use. there are diverging positions regarding the risks and benefits of cannabis, and a system similar to vincent could enable users to further investigate the debate and make sense of the data from existing websites. with such a system, users would be able to quickly identify the positions of different websites (i.e., proor anti-cannabis, medical or recreational focus on cannabis, and so on), obtain a geographic breakdown of website locations, determine the focus of each website, and identify the detected emotions about various concepts related to cannabis (i.e., “essential oils” or “epilepsy”). performing tasks such as these could help researchers acquire valuable insight into the online debate on cannabis and determine what (if any) actions could be taken (or policies adopted) to improve public health in this area. 4.1 limitations there were two key limitations to the development of vincent. the first set of limitations was related to the data and analysis tools that we used. social media data could have generated very rich and revealing data for investigation, but these types of data are proprietary and not freely accessible to conduct research of this scale. moz link explorer provided only enough data on inlinks for an adequate co-link analysis at the domain inlink level; getting data for the pageor site-level analysis was not feasible due to the associated cost. as the trend in the area of webometrics is towards collected data becoming increasingly proprietary, researchers need to consider alternative ways of making do with the limited data availability. additionally, resources like the nlu api are limited in their ability to analyze the websites emotions. tools like nlu api are essentially only in the infancy of their development. in the future, tools for emotion detection and nlp will certainly improve and be able to achieve a broader range of analysis and better results than are currently possible. the second set of limitations was related to the interaction capabilities afforded by tableau as a toolkit. for example, it was not possible in tableau to allow the filtering interaction to also filter vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi the word cloud selection. ideally, a user would want to be able to see word clouds of the top 25 words of any subset of websites selected in the other visualizations. however, given the manner by which tableau allows for the structure of data, and the data management solutions it works with, this was not possible to achieve. the work-around we used for this was to create the website selection interaction that allowed individuals to filter for a specific website throughout vincent. 4.2 future research in a follow up paper, we plan to conduct user testing of vincent to evaluate whether there is observable benefit to using vincent, and, if so, to what extent and in what ways. the findings of this research will lead to the development of best practices for creating similar vases. they will also help with the identification of potential benefits of vincent-like systems that can support exploration of similar public health issues. references 1. o’carroll p. introduction to public health informatics. in: o’carroll p, yasnoff wa, ward me, ripp lh, martin el, editors. public health informatics and information systems. new york, ny, usa: springer-verlag; 2003. p. 3–15. 2. ola o, sedig k. 2014. the challenge of big data in public health: an opportunity for visual analytics. online j public health inform. 5(3):e223, 1–21. 3. otterman s. new york confronts its worst measles outbreak in decades. new york times [internet]. 2019 jan 17; available from: https://www.nytimes.com/2019/01/17/nyregion/measles-outbreak-jews-nyc.html 4. oliviero h. whooping cough is making a comeback. here’s why. the toronto star [internet]. 2018 sep 4; available from: https://www.thestar.com/life/2018/09/04/whoopingcough-is-making-a-comeback-heres-why.html 5. abbott b. washington state becomes latest hot spot in measles outbreak. the wall street journal [internet]. 2019 jan 23; available from: https://www.wsj.com/articles/washingtonstate-becomes-latest-hot-spot-in-measles-outbreak-11548281172 6. who.int. ten health issues who will tackle this year [internet]. 2019 [cited 2019 feb 12]. available from: https://www.who.int/emergencies/ten-threats-to-global-health-in-2019 7. durbach n. 2000. ‘they might as well brand us’: working-class resistance to compulsory vaccination in victorian england. soc hist med. 13(1), 45-63. pubmed https://doi.org/10.1093/shm/13.1.45 8. fox s, rainie l. the online health care revolution. pew internet & american life project. available from: https//www.pewinternet.org/2000/11/26/the-online-health-care-revolution/. 2000 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11624425&dopt=abstract https://doi.org/10.1093/shm/13.1.45 vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi 9. lewandowsky s, oberauer k. 2016. motivated rejection of science. curr dir psychol sci. 25(4), 217-22. https://doi.org/10.1177/0963721416654436 10. kata a. 2010. a postmodern pandora’s box: anti-vaccination misinformation on the internet. vaccine. 28(7), 1709-16. pubmed https://doi.org/10.1016/j.vaccine.2009.12.022 11. kata a. 2012. anti-vaccine activists, web 2.0, and the postmodern paradigm an overview of tactics and tropes used online by the anti-vaccination movement. vaccine. 30(25), 377889. pubmed https://doi.org/10.1016/j.vaccine.2011.11.112 12. ninkov a, vaughan l. 2017. a webometric analysis of the online vaccination debate. j assoc inf sci technol. 68(5), 1285-94. https://doi.org/10.1002/asi.23758 13. vaughan l, ninkov a. 2018. a new approach to web co-link analysis. j assoc inf sci technol. 69(6), 820-31. https://doi.org/10.1002/asi.24000 14. brunson ek, sobo ej. 2017. framing childhood vaccination in the united states: getting past polarization in the public discourse. hum organ. 76(1), 38-47. https://doi.org/10.17730/0018-7259.76.1.38 15. mitra t, counts s, pennebaker jw. understanding anti-vaccination attitudes in social media. in: proceedings of the tenth international conference on web and social media; cologne, germany. 2016. p. 269–78. 16. keim d, andrienko g, fekete jd, görg c, kohlhammer j, et al. visual analytics: definition, process, and challenges. in: lecture notes in computer science (including subseries lecture notes in artificial intelligence and lecture notes in bioinformatics). 2008. p. 154–75. 17. börner k. atlas of knowledge: anyone can map. boston, usa: mit press; 2015. 18. sedig k, parsons p. 2016. design of visualizations for human-information interaction: a pattern-based framework. vol. 4, synthesis lectures on visualization. 1–185 available from: http://www.morganclaypool.com/doi/abs/10.2200/s00685ed1v01y201512vis005 19. sedig k, parsons p, babanski a. 2012. towards a characterization of interactivity in visual analytics. j multimed process technol spec issue theory appl vis anal. 3(1), 12-28. 20. han j, pei j, kamber m. data mining: concepts and techniques. burlington (ma), usa:morgan kauffman publishers; 2011. 21. shneiderman b, plaisant c, hesse bw. 2013. improving healthcare with interactive visualization. computer. 46(5), 58-66. 22. salomon, g. no distribution without individuals’ cognition: a dynamic interactional view. in: saloman, g., editor. distributed cognitions: psychological and educational considerations. cambridge, u.k.: cambridge university press; 1997. p. 111–38. https://doi.org/10.1177/0963721416654436 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20045099&dopt=abstract https://doi.org/10.1016/j.vaccine.2009.12.022 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22172504&dopt=abstract https://doi.org/10.1016/j.vaccine.2011.11.112 https://doi.org/10.1002/asi.23758 https://doi.org/10.1002/asi.24000 https://doi.org/10.17730/0018-7259.76.1.38 vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi 23. liu z, nersessian n, stasko j. 2008. distributed cognition as a theoretical framework for information visualization. ieee trans vis comput graph. 14(6). pubmed 24. sedig k, parsons p. 2013. interaction design for complex cognitive activities with visual representations: a pattern-based approach. ais trans human-computer interact. 5(2), 84113. https://doi.org/10.17705/1thci.00055 25. skyttner l. general systems theory: problems, perspectives, practice. singapore: world scientific publishing co.; 2005. 26. bostock m, ogievetsky v, heer j. 2011. d3data-driven documents. ieee trans vis comput graph. 17(12), 2301-09. pubmed https://doi.org/10.1109/tvcg.2011.185 27. nair l, shetty s, shetty s. 2016. interactive visual analytics on big data: tableau vs d3.js. j e-learning. knowl soc. 12(4), 139-50. 28. hund m, böhm d, sturm w, sedlmair m, schreck t, et al. 2016. visual analytics for concept exploration in subspaces of patient groups [internet]. brain inform. 3(4), 233-47. doi:https://doi.org/10.1007/s40708-016-0043-5. pubmed 29. cao n, gotz d, sun j, qu h. 2011. dicon: interactive visual analysis of multidimensional clusters. ieee trans vis comput graph. 17(12), 2581-90. pubmed https://doi.org/10.1109/tvcg.2011.188 30. cho i, wesslen r, volkova s, ribarsky w, dou w. crystalball: a visual analytic system for future event discovery and analysis from social media data. in: 2017 ieee conference on visual analytics science and technology (vast); phoenix, usa. 2017. p. 25–35. 31. pathak n, henry mj, volkova s. understanding social media’s take on climate change through large-scale analysis of targeted opinions and emotions. in: 2017 aaai spring symposium series; palo alto, california. 2017. p. 45-52. 32. beigi g, hu x, maciejewski r, liu h. an overview of sentiment analysis in social media and its applications in disaster relief. in: sentiment analysis and ontology engineering. new york, usa: springer; 2016. p. 313–40. 33. thelwall m, vaughan l, björneborn l. 2005. webometrics. arist. 39(1), 81-135. 34. thelwall m. 2008. bibliometrics to webometrics [internet]. j inf sci. 34(4), 605-21. http://journals.sagepub.com/doi/10.1177/0165551507087238. https://doi.org/10.1177/0165551507087238 35. stuart d. web metrics for library and information professionals. london, u.k.: facet publishing; 2014. https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18988961&dopt=abstract https://doi.org/10.17705/1thci.00055 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22034350&dopt=abstract https://doi.org/10.1109/tvcg.2011.185 https://doi.org/10.1007/s40708-016-0043-5 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27747817&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22034380&dopt=abstract https://doi.org/10.1109/tvcg.2011.188 https://doi.org/10.1177/0165551507087238 vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi 36. thelwall m. link analysis: an information science approach [internet]. bringley, u.k.: emerald group publishing limited; 2004. 88–91 p. available from: http://linkanalysis.wlv.ac.uk/index.html 37. thelwall m. 2001. extracting macroscopic information from web links. j am soc inf sci technol. 52(13), 1157-68. https://doi.org/10.1002/asi.1182 38. thelwall m, zuccala a. 2008. a university-centred european union link analysis. scientometrics. 75(3), 407-20. https://doi.org/10.1007/s11192-007-1831-8 39. vaughan l, wu g. 2004. links to commercial websites as a source of business information. scientometrics. 60(3), 487-96. https://doi.org/10.1023/b:scie.0000034389.14825.bc 40. holmberg k, thelwall m. 2009. local government web sites in finland: a geographic and webometric analysis [internet]. scientometrics. 79(1), 157-69. doi:https://doi.org/10.1007/s11192-009-0410-6. 41. ortega jl, aguillo if. 2008. visualization of the nordic academic web: link analysis using social network tools. inf process manage. 44(4), 1624-33. https://doi.org/10.1016/j.ipm.2007.09.010 42. thelwall m. 2009. introduction to webometrics: quantitative web research for the social sciences. synth lect inf concepts retr serv. 1(1), 1-116. https://doi.org/10.2200/s00176ed1v01y200903icr004 43. vaughan l, you j. 2008. content assisted web co-link analysis for competitive intelligence. scientometrics. 77(3), 433-44. https://doi.org/10.1007/s11192-007-1999-y 44. vaughan l, you j. 2010. word co-occurrences on webpages as a measure of the relatedness of organizations: a new webometrics concept. j informetrics. 4(4), 483-91. https://doi.org/10.1016/j.joi.2010.04.005 45. vaughan l, you j. comparing business competition positions based on web co-link data: the global market vs. the chinese market. in: scientometrics. 2006. p. 611–28. 46. holmberg k. webometric network analysis: mapping cooperation and geopolitical connections between local government administration on the web. turku, finland: åbo akademis förlag-åbo akademi university press; 2009. 47. holmberg k. webometric network analysis: mapping cooperation and geopolitical connections between local government administration on the web. åbo akademis förlagåbo akademi university press; 2009. 48. kim jh, barnett ga, park hw. 2010. a hyperlink and issue network analysis of the united states senate: a rediscovery of the web as a relational and topical medium. j assoc inf sci technol. 61(8), 1598-611. https://doi.org/10.1002/asi.1182 https://doi.org/10.1007/s11192-007-1831-8 https://doi.org/10.1023/b:scie.0000034389.14825.bc https://doi.org/10.1007/s11192-009-0410-6 https://doi.org/10.1016/j.ipm.2007.09.010 https://doi.org/10.2200/s00176ed1v01y200903icr004 https://doi.org/10.1007/s11192-007-1999-y https://doi.org/10.1016/j.joi.2010.04.005 vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi 49. romero-frías e, vaughan l. 2010. european political trends viewed through patterns of web linking. j assoc inf sci technol. 61(10), 2109-21. https://doi.org/10.1002/asi.21375 50. hirschberg j, manning cd. 2015. advances in natural language processing. sciencenat. 349(6245), 261-66. pubmed https://doi.org/10.1126/science.aaa8685 51. liu b. sentiment analysis: mining opinions, sentiments, and emotions. cambridge university press; 2015. 52. rubin vl, stanton jm, liddy ed. discerning emotions in texts. in: the aaai symposium on exploring attitude and affect in text (aaai-eaat). stanford, usa. 2004. 53. ptaszynski m, masui f, rzepka r, araki k. 2014. emotive or non-emotive: that is the question. in: proceedings of the 5th workshop on computational approaches to subjectivity, sentiment and social media analysis; baltimore, usa. 2014: p. 59-65. https://doi.org/10.3115/v1/w14-2610 54. tokuhisa r, inui k, matsumoto y. emotion classification using massive examples extracted from the web. in: proceedings of the 22nd international conference on computational linguistics; manchester, u.k.; 2008. p. 881–8. 55. vergara s, el-khouly m, el tantawi m, marla s, lak s. building cognitive applications with ibm watson services: volume 7 natural language understanding. in: tech rep. ibm corporation; 2017. p. 98. 56. palomino m, taylor t, göker a, isaacs j, warber s. 2016. the online dissemination of nature–health concepts: lessons from sentiment analysis of social media relating to “nature-deficit disorder.”. int j environ res public health. 13(1), 142. pubmed https://doi.org/10.3390/ijerph13010142 57. meehan k, lunney t, curran k, mccaughey a. context-aware intelligent recommendation system for tourism. in: 2013 ieee international conference on pervasive computing and communications workshops, percom workshops 2013. 2013. p. 328–31. 58. rizzo g, troncy r. nerd: a framework for evaluating named entity recognition tools in the web of data. in: international semantic web conference, demo session; bonn, germany. 2011; p. 1–4. 59. saif h., he y., alani h. semantic sentiment analysis of twitter. in: cudré-mauroux p, et al., editors. international semantic web conference, lecture notes in computer science; boston, usa. 2012; p. 508 – 524. 60. katsuki t, mackey tk, cuomo r. 2015. establishing a link between prescription drug abuse and illicit online pharmacies: analysis of twitter data. j med internet res. 17(12), e280. pubmed https://doi.org/10.2196/jmir.5144 https://doi.org/10.1002/asi.21375 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26185244&dopt=abstract https://doi.org/10.1126/science.aaa8685 https://doi.org/10.3115/v1/w14-2610 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26797628&dopt=abstract https://doi.org/10.3390/ijerph13010142 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26677966&dopt=abstract https://doi.org/10.2196/jmir.5144 vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi 61. mcauley j, leskovec j, jurafsky d. learning attitudes and attributes from multi-aspect reviews. in: data mining (icdm), 2012 ieee 12th international conference on data mining; brussels, belgium. 2012. p. 1020–5. 62. healey c, ramaswamy s. visualizing twitter sentiment. sentim viz [internet]. 2011; available from: https://www.csc2.ncsu.edu/faculty/healey/tweet_viz/tweet_app/ 63. bird s, klein e, loper e. natural language processing with python: analyzing text with the natural language toolkit. sebastopol, usa: o’reilly media, inc.; 2009. 64. grimes s. sentiment, emotion, attitude, and personality, via natural language processing [internet]. ibm. 2016 [cited 2019 jan 20]. available from: https://www.ibm.com/blogs/watson/2016/07/sentiment-emotion-attitude-personality-vianatural-language-processing/ appendix 1 set of websites name domain adult vaccination http://www.adultvaccination.org/ age of autism http://www.ageofautism.com/ australian vaccination-risks network http://avn.org.au/ experimental vaccines http://experimentalvaccines.org/ families fighting flu http://www.familiesfightingflu.org/ gavi the vaccine alliance http://www.gavi.org/ history of vaccines http://www.historyofvaccines.org/ immunization action coalition http://www.immunize.org/ immunize bc http://www.immunizebc.ca/ immunize canada http://immunize.ca institute for vaccine safety http://www.vaccinesafety.edu/ national vaccine information center http://www.nvic.org/ parents requesting open vaccine education http://vaccineinfo.net/ prevent childhood influenza http://www.preventchildhoodinfluenza.org/ sabin vaccine institute http://www.sabin.org/ safe minds http://www.safeminds.org/ sanevax http://sanevax.org/ vincent: a visual analytics system for investigating the online vaccine debate online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e5, 2019 ojphi shots of prevention http://shotofprevention.com/ the immunization partnership http://www.immunizeusa.org/ the informed parent http://www.informedparent.co.uk/ the thinking moms revolution http://thinkingmomsrevolution.com/ think twice global vaccine institute http://thinktwice.com/ vaccinate your family https://www.vaccinateyourfamily.org/ vaccination information network http://www.vaccinationinformationnetwork.com/ vaccination liberation http://vaclib.org/ vaccination news http://www.vaccinationnews.org/ vaccine choice canada http://vaccinechoicecanada.com vaccine injury help center http://www.vaccineinjuryhelpcenter.com/ vaccine injury info http://www.vaccineinjury.info/ vaccine liberation army http://vaccineliberationarmy.com/ vaccine resistance movement http://vaccineresistancemovement.org/ vaccine truth http://vaccinetruth.org/ vaccines today http://www.vaccinestoday.eu/ vaccines.gov http://www.vaccines.gov/ vaxxter http://vaxxter.com voices for vaccines http://www.voicesforvaccines.org/ world association for vaccine education http://novaccine.com/ http://vaccines.gov/ http://vaxxter.com/ layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts biosurveillance adaptable framework for teaming, exploration and reuse (bioafter) timothy dasey* and lars fiedler chemical and biological defense systems, mit lincoln laboratory, lexington, ma, usa introduction next-generation software environments for disease surveillance will need to have several important characteristics, among which are collaboration and search and discovery features, access to various data sets, and a variety of analytic methods. however, perhaps the most important feature is the least often mentioned – the ability to have the system adapt over time without high reengineering cost. the public health community cannot afford software redesigns every few years as data sets expand, analysis needs evolve, and software deficiencies are exposed. in addition to the need to adapt an environment over longer time periods, epidemiologists have high variability in their day-to-day needs that require adaptability over short time periods as well. each outbreak or health situation has unique aspects, and analysts need to be able to bring in data and methods unique to that situation that may not be easily anticipated a priori. the most common approach to increasing reusability and decreasing upgrade costs are open architecture software frameworks such as service-oriented architectures (soas). if well implemented, soas can significantly reduce software upgrade costs by allowing services (a software module) to be easily swapped out for improvements or supplemented with additional services. soas can help with long-term adaptability, but are not useful in short-term adaptability, since the software development team must be engaged in each cycle. another approach is to include an app store. unfortunately, app stores for government use have often been disappointing. apps can tend to be quite simple, and even slight changes from what is programmed – a predictable situation with the variability seen in disease surveillance realm will result in an epidemiologist having to get a software developer to make them a new app. methods instead of the power for adaptability remaining solely in the control of software developers, that power needs to also be in the hands of the users themselves. the bioafter project builds upon soa and app store concepts by allowing apps to be strung together in unique combinations, according to the problem of the day. as examples, these apps can be data access programs, data quality editing, algorithms of various complexity, or reporting and visualization modules. the app store feature allows software developers, including the public health academic community, to add new methods to the environment, while the composability feature allows ad-hoc combinations of apps to suit particular situations. the user composability feature would be of limited value without collaboration features in the environment. we expect that only a subset of users will make the effort to do composition. the rest will want to learn from those “super users”. the bioafter environment allows data, apps (including new apps created by compositions of other apps), and analysis results to be shared with the entire epidemiological community, or with a set of “friends” or people with common interests. analysts who use various apps can rate their value. the environment is intended to allow search and discovery of apps, expertise, or even people who may have needed expertise or experience with similar situations (these features are in development). results the motivations and features of the bioafter environment will be described at the isds conference, and a brief demonstration of the capabilities on an example use case will be given. keywords biosurveillance; collaboration; discovery; composition; adaptability acknowledgments this work is sponsored by the office of the assistant secretary of defense for research and engineering (asd(r&e)) under air force contract #fa8721-05-c-0002. opinions, interpretations, recommendations and conclusions are those of the authors and are not necessarily endorsed by the united states government. *timothy dasey e-mail: timd@ll.mit.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e201, 2013 ojphi-06-e19.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 56 (page number not for citation purposes) isds 2013 conference abstracts joe gibson1, bryant thomas karras2 and gideon s. gordon*3 1marion county public health department, indianapolis, in, usa; 2washington state department of health, shoreline, wa, usa; 3ehealth, association of state and territorial health officials, arlington, va, usa � �� �� �� � � �� �� �� � introduction �������� � �� �� ������ � ����� ��� �������������� ������������ ������������������������ ���������� � �� ������ �� ����������� ��� � ������������!�"��������# �������������� ����������������$��� �!�"�� �����"���� ���� �� �� ����������� �� ������������� �%���� ���%��&� ������� �� ��������&�������!����� �������� � �����'���!������������� ����� ������������ ������ ������������������� ����"������������������ ���� �� �� ������(�!��������(������������ ����������"��� � ��������� "���"���%"������"�������� ������!� ���� �� ��%"� ���������!� ���������� ���������!�"�������� � �� �� ������� ����(�!��������(�����)((*������ ���� �����������&����������� ������ ���!�������������"�!������������"��������������������������� �� �����������%"������"���+��� ������� �������� �� �� �� ���������� ��������������((��� ����������������� ��!�� �� ����� �� �� ������ ��������������� ��!����� �"� ���""���"���� �������������� �������� ��,����������������� �������������-����� ���� �������������� �� � ���� ������ �����"� �� �"������� ������� �� ��!�� � methods ��!���.��������������������%�����.���� � ������ ������ ����� �������� � ���������&��� ������������%���"������������ �� �� ������ �"���� ����� ��� ����"������ ���� �$� ����� � ����� ���� ��!��� "� ���� � ������������ � ��� ��������� ��!��""������ ���� ����"����"� � ����� ���!� ��"�,�������/� ������� �������������&���"������%����������� � ������ � �������� � ��������������0""�� �� �� � �� �� ���������!����� �����&������ ��!����/� ��� � �����������"�,���%��+��� ��������������� ���"� ������� ���"��"����� ��������������� ��!�������������������0���"���.1��� � ���� ������ ������ ����� �������������������"��� ��������"���������� � ��� �� �� ����������� ���� ����%�����������������!��� ��������������� �!��"� ��� ��� ����� ��������"���� � ��� ��������� ��!��""����� � ��� ����!�"�����%��20� ��'3� � �� ��!��""�����4��&������ ��!���1�����������������.1��� � ��� ��&���"������������,������� � ��%�������������� ���!�"����������� ����������� �!��%��������!��"�� �����"��������((��� �� ��� �� �� ��������!�"���������������� ���� �!���"� ������� �� ����������� ��� �!���������� ����� �� /� ������� � ������ &������ �"��������������.������� ����������&���� ������������ � ������������5� �������� ��� ������+��� �������������!���������� ����� ��������������&��� � ��������� ������������� ���""�%���!����������� �����������������������������%���� �+��� ������� ����� ������������ �������������!�"�� ���!��� �������� results /����� �������� �"��� ����� ��!�� �����%�� ������������(�!�������� ��%�����)����677������"����7 �� �� �(�!�������*� ��!���.6�118�� �� �� ��� ������� ����179�� ��""� �� �� ������+�� �� ������� ���������%���� ��� ������� �����+��� ��������!����������"��� ���� �� �� ��� ������ � ������ �� � 0��(� )����!� ��"�,������ ����� ����*�� 0 �) ���� ����"����"� � *������: :2�:�) ��������� ��!��"� "��������"� � *��# �� � ��������� ��!������%�� ���"���� ���������"���� ��!����6�.;8�� �� �� �������������������� � ��!������������"�� ������ �� ��� �� ����;<8�� � �� �� ������+��� ������� ��-�� ����������� ��� ���� ������� � ������ ���� ��������� ������� ����������"��������� � )���������� ����� �����������7�"� � ����*����"�������������������� ��""� ������ ����������"������""����� �������# �� � ��������� ��!������%�� ����"�$������������� ������ ��!���16�;�8�� � �� �� ������+��� ������� ��� ������������� � ��� !������������<���������� ������������ ��� ������������������������������ �������"�����"����" �������� ��������"���!��� ����������"����������� � ���" ���������������!� �%�"����������!� ��"�,����������������� �������� ����� �������� � conclusions #���� ���������������� �� �������%"������"������������� ��� ��� �� ��������!�"�������� ��������"����������������!�� � ���� ������((� � ����""���������%�"������� ��������������"������ ���� ��������%������� ������ �"� �� � ��!���.�������"�����%������� �������"������� ������� �������"���� ���� ������� ��!������� ��� ���������%�������������� ��� �!���%����� �!������� ����������"����������� ������ � ��� ����� "���"���"������ �����������,������ 0 ����� �"������������������&������ ��!���1�����"�������������� ��� �!����������������� ��!�� ������� �"������ �� ����+� ���������� �� /��&���������� ������ ���������������"� ���� ��""�,��������"���!����� ���������� �� �� ��=���""���� &���� �����"�������� ��� ������+��� ���� ������""��������"�������"������������������ ���� (�!�������� (����� � ������ � � � ���������� ������ ���� ���� �� �� �� ���� ���������� ��""� ��������� ��� ������� � � �� �� �� ���� �!�"!� ������(�!��������(�������""��������������!�"����������� ���� �� ���������� �����������"����� � ������ ��������� ������� ��� �� ����� ��%"������"������������� ��� � ������!�"������� keywords �� �� �>� �� �� �� ���>� ��������� ��!��""����>� ��!�������>� �"�� ��� *gideon s. gordon e-mail: sgordon@astho.org� � � � biosense 2.0 governance: surveying users and stakeholders for continued development online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e19, 2014 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts using information entropy to monitor chief complaint characteristics and quality shaun grannis*1, 2, brian dixon4, 2, yuni xia3 and jianmin wu4, 2 1indiana university school of medicine, indianapolis, in, usa; 2regenstrief institute, indianapolis, in, usa; 3indiana university purdue university indianapolis, indianapolis, in, usa; 4indiana university school of informatics, indianapolis, in, usa objective we describe how entropy, a key information measure, can be used to monitor the characteristics of chief complaints in an operational surveillance system. introduction health care processes consume increasing volumes of digital data. however, creating and leveraging high quality integrated health data is challenging because large-scale health data derives from systems where data is captured from varying workflows, yielding varying data quality, potentially limiting its utility for various uses, including population health. to ensure accurate results, it’s important to assess the data quality for the particular use. examples of sub-optimal health data quality abound: accuracy varies for medication and diagnostic data in hospital discharge and claims data; electronic laboratory data used to identify notifiable public-health cases shows varying levels of completeness across data sources; data timeliness has been found to vary across different data sources. given that there is clear increasing focus on large health data sources; there are known data quality issues that hinder the utility of such data; and there is a paucity of medical literature describing approaches for evaluating these issues across integrated health data sources, we hypothesize that novel methods for ongoing monitoring of data quality in rapidly growing large health data sets, including surveillance data, will improve the accuracy and overall utility of these data. methods our analysis used chief complaint data derived from the original real-time hl7 registration transactions for ed encounters over a 3year study period between january 1, 2008 and december 30, 2010 from over 100 institutions participating in the indiana public health emergency surveillance system (phess) [1]. we used the following syndrome categories based on various definitions: respiratory, influenza like illness, gastrointestinal, neurological, undifferentiated infection, skin, and lymphatic. we calculated entropy for chief complaint data [2]. entropy measures uncertainty and characterizes the density of the information contained in a message, commonly measured in bits. we analyzed entropy stratified a) by syndrome category, b) by syndrome category and time, and c) by syndrome category, time, and source institution. results analysis of more than 7.4 million records revealed the following: first, overall information content varied by syndrome, with “neurological” showing greatest entropy (figure 1). second, entropy measures followed consistent intraorganizational trends: information content varied less within an organization than across organizations (figure 2). third, information entropy enables detection of otherwise unannounced changes in system behavior. figure 3 illustrates the monthly entropy measures for the respiratory syndrome from 5 sources over 36 months. one source changed registration software. their visit volume didn’t change, but the information content of the chief complaint changed, as indicated by a substantial shift in entropy. conclusions as we face greater data volumes, methods assessing the data quality for particular uses, including syndrome surveillance, are needed. this analysis shows the value of entropy as a metric to support monitoring of surveillance systems. future work will refine these measures and further assess the inter-organizational variations of entropy. keywords analytics; data quality; surveillance; system monitoring; information theory acknowledgments this work was performed at the regenstrief institute in indianapolis, indiana. this study is supported in part by the cdc through the indiana center of excellence in public health informatics (1p01hk000077-01). online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e16, 2013 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts references 1. finnell jt, overhage jm, grannis s. all health care is not local: an evaluation of the distribution of emergency department care delivered in indiana. amia annu symp proc. 2011; 409-16. 2. shannon, claude e. (july/october 1948). “a mathematical theory of communication”. bell system technical journal 27 (3): 379–423. *shaun grannis e-mail: sgrannis@regenstrief.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e16, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts an experimental study using opt-in internet panel surveys for behavioral health surveillance carol a. gotway crawford*1, catherine a. okoro1, haci m. akcin1 and satvinder dhingra2, 1 1centers for disease control, atlanta, ga, usa; 2northrop grumman, atlanta, ga, usa objective to present the design and preliminary results of a pilot study to investigate the use of opt-in internet panel surveys for behavioral health surveillance. introduction today, surveyors in both the private and public sectors are facing considerable challenges with random digit dialed (rdd) landline telephone samples. the population coverage rates for landline telephone surveys are being eroded by wireless-only households, portable telephone numbers, telecommunication barriers (e.g., call forwarding, call blocking and pager connections), technological barriers (call-blocking, busy circuits) and increased refusal rates and privacy concerns. addressing these issues increasingly drives up the costs associated with dual-frame telephone surveys designed to be representative of the target population as well as hinders their ability to be fully representative of the adult population of each state and territory in the united states. in an effort to continue to meet these challenges head on and assist state and territorial public health professionals in the continued collection of data that are representative of their respective populations, novel approaches to behavioral health surveillance need continued examination. both private and public sector researchers are evaluating the use of internet opt-in panels to augment dual-frame rdd survey methods. compared to dual-frame rdd, opt-in internet panels offer lower costs, quick data collection and dissemination, and the ability to gather additional data on panelists over time. however, as with dual-frame rdd, this mode has similar challenges with coverage error and non-response. nevertheless, survey methodologists are moving forward and exploring ways to reduce or eliminate biases between the sample and the target population. methods a collaborative pilot project was designed to assess the feasibility and accuracy of opt-in internet panel surveys for behavioral health surveillance. this pilot project is a collaboration between the cdc, four state departments of health, opt-in internet panel providers and the leads of several large surveys and systems such as the patientreported outcome measures information system (promis) and the cooperative congressional election study (cces). pilot projects were conducted in four states (ga, il, ny, and tx) and four metropolitan statistical areas (atlanta, chicago, new york city, and houston). data were collected using three different opt-in internet panels and sampling methods that differ with respect to recruitment strategy, sample selection and sample matching to the adult population of each geography. a question bank consisting of 80 questions was developed to benchmark with other existing surveys used to assess various public health surveillance measures (e.g., the behavioral risk factor surveillance system, the promis, national survey on drug use and health, and the cces). results we present comparative analyses that assess the advantages and disadvantages of different opt-in internet panels sampling methodologies across a range of parameters including cost, geography, timeliness, usability, and ease of use for technology transfer to states and local communities. recommendations for future efforts in behavioral health surveillance are given based on these results. keywords random digit dialing; brfss; survey methods; sample matching; representativeness references ansolabehere s, schaffner bf. 2010. re-examining the validity of different survey modes for measuring public opinion in the u.s.: findings from a 2010 multi-mode comparison. http://projects.iq.harvard. edu/cces/files/ansolabehere_schaffner_mode.pdf. curtin r, presser s, singer e. 2005. changes in telephone survey nonresponse over the past quarter century. public opinion quarterly;69(1):87-98. liu h, cella d, gershon r, shen j, morales ls, riley w, hays rd. 2010. representativeness of the patient-reported outcomes measurement information system internet panel. j clin epidemiol 63(11):1169-78. rivers, d., 2007. sampling for web surveys, paper presented at the joint statistical meetings. http://www.laits.utexas.edu/txp_media/html/ poll/files/rivers_matching.pdf *carol a. gotway crawford e-mail: cdg7@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e24, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts serum zinc concentration and acute diarrhea in children from different regions of uzbekistan gulnara a. ibadova*, t. a. merkushina, e. s. abdumutalova and aybek v. khodiev infectious and parasitic diseases of children, tashkent institute of postgraduate medical education, tashkent city, uzbekistan objective to study the blood serum zinc concentration in children with acute diarrhea (ad) in in-patient facilities before and after therapy. introduction there are several reports of zinc deficiency in pathogenesis of acute and chronic diarrhea. the literature review showed children with diarrhea and chronic gastroduodenitis performed zinc deficiency in majority of cases (1). the normal values of zinc in blood serum are 12.8-27.8 µmol/l (2). there is a threshold of 13µmol/l zinc concentration for zinc deficiency diagnosis. the zinc level 8.2 µmol/l and below is poor prognostic criteria (3). methods totally 102 children (1-14 years old) with ad in in-patient facility from different regions were studied for serum zinc concentration before and after treatment. termez and saraosie cities are located in south of uzbekistan, in the region with high negative impact from the nearly tajikistan located aluminum producing plant. the serum zinc level measured by neutron-activation method in the institute of nuclear research (inr). results the zinc concentration in serum significantly varied by the region (table 1). the level of zinc in children from tashkent estimated at lower normal limit with reduction below normal values after treatment. children from termez during admission to the in-patient facilities were zinc deficient with further reduction to the poor prognostic level. children in saraosie admitted to the in-patient with significant zinc deficiency that remained on poor prognostic level after treatment. conclusions the study results may indicate the treatment of ad in children do not replenish the zinc to the appropriate level. though some confounding factors may contribute the observed zinc disorders the results may indicate environmental factors, such as pollution by aluminum producing plant emission to contribute the difference in zinc concentration and should be considered for the correction and treatment of ad in children. table 1.the serum zinc concentration in children with acute diarrhea from different regions of uzbekistan before and after treatment. keywords acute diarrhea; zinc; zinc deficiency acknowledgments authors express their gratitude to the staff of institute of nuclear research. references 1. brooks wa, santosham m, roy sk, faruque asg, wahed ma, nahar k, khan ai, khan a f, fuchs gj, black re. efficacy of zinc in young infants with acute watery diarrhea. [internet]. the american journal of clinical nutrition 2005 sep;82(3):605–10.available from: http://www.ncbi.nlm.nih.gov/pubmed/16155274 2. ackland ml, michalczyk a. zinc deficiency and its inherited disorders -a review. [internet]. genes & nutrition 2006 mar;1(1):41– 9.available from: http://www.ncbi.nlm.nih.gov/pubmed/18850219 3. karlinskiy vm. zinc deficiency syndrome. nutrition issues 1980;1:10– 18. *gulnara a. ibadova e-mail: prof.ibadova@mail.ru online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e181, 2013 editorial: volume 2, number 1 (2010) 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 editorial: volume 2, number 1 (2010) welcome to the first issue of the 2nd volume of the online journal of public health informatics, the first journal dedicated to the dissemination of information about the best public health informatics practices among practitioners, researchers, and educators. by all accounts, interest in the journal has been overwhelming, as evidenced by the growth in submission of original articles. this issue contains five original articles and one review article. topics covered in the original articles range from the construction of a flexible query interface for web-based disease surveillance systems to the use of cloud computing to provide on-demand resources for epidemic analysis. in the first article, titled advanced querying features for disease surveillance systems, the authors build a flexible interface for web-based surveillance disease systems. the interface allows users from different health departments and jurisdictions to build, save, and share queries, thereby improving the efficiency of operations and, under certain circumstances, eliminate the need for application developers and database administrators to make modifications to the surveillance systems. the second article presents a method for integrating aberration detection models into disease surveillance systems in order to identify deviations from expected patterns. it is quite possible that different aberration algorithms will generate different results when applied to the same datasets. this will present problems to public health experts responsible for making resource allocating decisions for controlling disease outbreaks. the methodology developed in this paper accounts for the relationships between multiple algorithms and enables public health professionals to interpret aberration detection results with some degree of confidence. successful intervention and containment of an epidemic depends on the early detection and timely response to outbreaks by epidemiologists and other health professionals. the analytical processes involved in accurately identifying outbreaks of epidemics can be very resource-intensive and are usually beyond the human and financial resources available in an average state health department. the third article, titled on-demand large scale spatial analysis of epidemics, uses cloud computing to provide on-demand resources for epidemic analysis by using satscan, a software application for identification of disease clusters at the initial stages of an outbreak. an advantage of cloud computing is that it provides the required computational resources within the budgetary constraints of the typical health department. the healthcare system’s ability to rapidly detect and respond to emerging threats is compromised by the lack of integration and interoperability between the disparate surveillance systems in the nation. this creates inefficiencies in analysis and communication, resulting in increased morbidity, mortality, and costs. the fourth article, titled using secure web services to visualize poison center data for nationwide biosurveillance, demonstrates the use of a federated data exchange model and secures web services to enhance existing biosurveillance capacity. editorial: volume 2, number 1 (2010) 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 colorectal cancer is a major cause of mortality among american men and women. in the fifth article the authors used geographic information systems and asset mapping technologies to explore the availability and accessibility of colorectal cancer screening resources in medically underserved communities. the paper yielded asset maps that helped in the development of targeted strategies for addressing the barriers to colorectal cancer screening. experts in the field of disaster management have long recognized that an up-to-date continuity of operations plan (coop) is a core component of any disaster preparedness and response strategy. recent experiences in disaster management, involving sars, hurricane katrina, and the h1n1 influenza threat, demonstrate that public health departments lack access to decision support technologies for coop planning. in the final article, titled use of technology to support information needs for continuity of operations planning, the authors review published studies of information systems and technology projects that are applicable to public health continuity of operations planning. the findings from this review article will assist public health informaticians in the development of information systems to support public health operational continuity. edward mensah, phd editor-in-chief online journal of public health informatics 1603 w taylor st, rm 757 chicago. il. 60612 email: dehasnem@uic.edu office: (312) 996-3001 mailto:dehasnem@uic.edu ojphi-06-e89.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 28 (page number not for citation purposes) isds 2013 conference abstracts analytic biosurveillance methods for resource-limited settings howard burkom*, yevgeniy elbert, erhan guven and jacqueline coberly johns hopkins applied physics laboratory, laurel, md, usa � �� �� �� � � �� �� �� � objective �������� ���� �� �� ����� � ������� ������ �������� ������� � ������� � ���������� ���� ������ �� �� � ������������� � ���������� ���������� �� ��������� � ����������� ������� introduction �� �� ������������ �� � ����������������������������������������� ��� ������������ ���� ����������� � ���������������� ���������� �� � ������������������ ������������ ���������������� �� � !��������� � �� ��������� �� ������������������� �����������������"������������� � ���!������������������� ������ ������ ������ ���������#$%��&���� �� �������������� ����������������������������� �������������������� ���� ����������������� ����� �������� � ������&������ �'�� ������ (� ����)���� ������ &� ����������&'()&�������� ������ �� ��� �� ��� !�� ������ ��������� ���� ��� ���� ������������� ������ ��������� ������������������#*%��������� ��� �"�� ����������������� ��������� ��� ��� � ������ �&'()&�����!������� �� ������ ����������� ���������� ���+���� ���������� �� ,��� ����������� ��������� ���� ��� ����������-���������� ���� ������� ����� ���� ��� ���������������������� � ��������������!����� ���������� ���������� ������������� ��� ��� �������� ��� ���� ���� ������������� ��� ������������������ �������� ����������������� ������� �� ����������� ���������������� ���������� �������� �������!�������������� �� �� �� ��&�������������� ���������������� � �� � ������ methods . �� ��� �� ��������������������!�������������������&'()&� ������� ����������������� ������ ����������� ��� ������ � ����$/� ���� ���� �0�� �������.��� �&'()&�������� ��� �������� ���������� �����!�� �������� ������ �������������� ������������� ���������� �� ������ ��� �� ��� ��������������!���� � ����� �������!��������� �� ���������� ����. �������� ���� � �������������!��������� �� ��������� ��� �������������� ����+��������� ��������� ��������� ��� ��� �� � ����� ��������������������� ������� ��� �������������*������� ����� ���� ����� �������1������� ����!��������+������� �������+������� � �������� ������������ ����������� ���� ��� ����� ��� �������� ��� �������� ��23&34�����),4'���� ������������ �&'()&!������� ������ �� ������252�)'6&�2*���� ����!�����(&7&'()&!������� �� ������ ������ ��������1� ���������� ���������������� ���+����� � � � ��������������� � ����� ������������ �"�� ������� �� �� ���� �� � ������8����� � ���� ���� ����������� ������� �����������&'()&�� ) ������ ��� ��� ��� ��������� ���� ��� � �� ��+������� �������������� �� ����������� ����!������������ ��������� �� ����+���� ��� ���� ����� ������������!����� ��� � ����+������� �������� �������+�������������� � ���������� ���!� �� �� �����!����� ��� � ����+������� �������� �������� �� ������99:�!����� ������������������ ������� �� ������������������� 6�� �������� ����� ���� � ���� ������������� �������� ����� ������� ������������������������ ���������� ������� ��� ������������� ���� ������ ��� ���� �� ����������� ������;�/0<�!�� �� ������;*0<�!� 99:��;=><�!������������������;/?<��� results 6������-� '�� ����� �� �������� ��� � � &'()&� ��� �� �� �� ���������� ����� �"�������������� ������� ����������������9� ����� �� ���������������� � ��������� ������ ��� ��� ��� � ��� ������� �� ����������������������� ��� conclusions 8����� � ������� ������ ��������� ����� ��������� �� ��������� �� �������� ���� ��� �����������������1������� �� � ����������� ������������ ��������������� ��� ��� � ��� ������� �������� � ���� �� � ��������� ������������� ��� �!��������� ������ �� ������ ��� ��� �� ���� � ���� �����������,������������� � ������������ ��!����� ����� ��������������99:������ �� ����!������������!������ � ������� �� ������������� ���+�������� ������� ��� ��!� ��� ���������� ���������� ����� ��� �������� ������ ��� ���� '�� �����6�� �������� ������5����2 ����� � 2 ���-�$@� ��� ��!�*@����������!�=@� �� �� ������� keywords ��� ����a�� �� ����� �a��1� ���������� �����a�&'()&a� �� � ��� ������� acknowledgments �������� ������ ������������������ ������3�&��' ����. ���� ������ &� ���������2���� �(� ����)�� �����b������ ��&�����!����������������� ��� ��� ������� references $�� 2� ������c9!��� � �� &!�d�����& !���������*>>/��&��� ����&� ���� �����-�'��������b�� ��� ���� �5� �� �����&���������9d &�4�������� 0�=�-��?* *�� d�����&d!�.������ �� !�d ������,'!���������*>$$��&'()&-�'�&����� ��. �����' ��������& ���� ��� ���� �)���� ����5�������&� ���� ���������6�� � ���d�������&���������9d &�8e)�f�0�-��$/?0> *howard burkom e-mail: howard.burkom@jhuapl.edu� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e89, 2014 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts rabies vaccination coverage and antibody profile of owned dogs in abuja, nigeria grace o. olayemi*1, jarlath u. umoh1, grace s. kia1 and asabe a. dzikwi2 1veterinary public health and preventive medicine, ahmadu bello university zaria, zaria, nigeria; 2university of jos, department of vet public health, jos, nigeria objective to determine the vaccination status of owned dogs, assess the rabies antibody titre of vaccinated dogs and risk factors associated with vaccination of dogs in abuja, nigeria. introduction rabies is a zoonotic disease of high public health importance1. there have been documented reports of rabies in vaccinated dogs2. rabies is enzootic in domestic dogs in nigeria. hence, annual vaccination campaigns of dogs are advocated with the aim of rabies elimination. vaccination status, type of vaccination and the immunogenicity of the various rabies vaccines used in abuja nigeria has not been studied. to date, no effective medical therapy has been established for rabies3. most human rabies deaths occur in the developing countries and though effective and economical control measures are available their application in developing countries is hampered by a range of economic, social and political factors. it is widely recognized that the number of deaths officially reported in most developing countries greatly underestimates the true incidence of disease, with several factors contributing to widespread underreporting3. preventive vaccination against rabies virus is a highly effective method for preventing rabies in humans and animals3 but do people vaccinate and how long does the immunity conferred by the vaccine remain protective in the dogs in abuja?. rabies has high financial expenditure burden on any country where it is endemic mainly associated with costs incurred on post-exposure prophylaxis (determined by the type of vaccine, vaccine regimen and route of administration as well as the type of immunoglobulin used). methods dog serum samples (n=276) were collected from abuja the federal capital territory (fct) nigeria, from 5 locations (phase 1, 2, 3, gwagwalada and kubwa) based on availability and owners consent. rabies antibody serum titer was determined using an indirect enzyme linked immuno-sorbent assay. face to face structured questionnaires were used to obtain demographic and zoographic information from the dog owners. associations between the demographic variables, vaccination status and rabies antibody titer of each dog were assessed using χ2 analysis. results of the dogs sampled, 229 (83%) had certified antirabies vaccination record. the dogs sampled, which were vaccinated from phase i, ii, iii and the satellite towns were; 109/118 (92.37%), 32/33 (96.97%), 48/49 (97.96%) and 40/76 (52.63%), respectively. a total of 276 serum samples were collected, processed and analyzed during this study. out of the 276 dogs sampled, 239 (86.6%) had rabies antibody titre ≥ 0.6eu/ml whilst 37 (13.4%) had less than 0.6eu/ml. there was a marked decline in rabies antibody titre with increase in time. out of the 228 exotic breeds of dogs sampled, 218 (95.6%) were vaccinated whilst 11 (22.9%) of the 48indigenous breed of dogs sampled were vaccinated. all the exotic breed of dogs had rabies antibody titre ≥ 0.6eu/ml whilst 37 (77.1%) of the indigenous breed of dogs had less than 0.6 eu/ml levels of rabies antibody titre. all dogs within 6 months to 1 year and greater than 10 years of age had ≥ 0.6eu/ml rabies antibody titre whilst dogs within 1-5 years had 1 (0.5%) and 36(69.2%) dogs of age 6-10 years had rabies antibody titre < 0.6eu/ml. twelve (7.6%) of the males and 25 (21.2%) of the females had less than 0.6eu/ml rabies antibody titre. all the dogs acquired by importation and from breeders had rabies antibody titre ≥ 0.6eu/ml whilst 37 (27.2%) of the dogs acquired from friends had less than 0.6eu/ml rabies antibody titre. significant associations were observed between breed (χ2 = 203, df = 1, p-value < 0.05), age (χ2 = 172, df = 3, p-value < 0.05), sex (χ2 = 10.75, df = 1, p-value < 0.05), source (χ2 = 43.99, df = 2, p-value < 0.05), rabies vaccination status (χ2 = 276.00, df = 2, p-value < 0.05) and the rabies antibody prevalence of sampled dogs. conclusions this cross-sectional study shows that not all dog owners vaccinate their dogs and that the vaccines conferred protection beyond 12 months. the preventive vaccination against rabies virus is a highly effective method for preventing rabies in humans and animals. policies to enhance mass mandatory annual vaccination to achieve 70% coverage should be implemented in order to eradicate rabies. keywords rabies; antibody; antirabies vaccine; abuja nigeria; dog owners acknowledgments we acknowledge the macarthur foundation msc. epidemiology, department of veterinary public health and preventive medicine ahmadu bello university zaria the sponsorship for o.g. oladiran/vet. med./53282/abu2012-2013. references 1. adedeji, a.o., eyarefe, o.d., okonko, i.o., ojezele, m.o., amusan, t.a. and abubakar, m.j. (2010). why is there still rabies in nigeria? a review of the current and future trends in the epidemiology, prevention, treatment, control and possible elimination of rabies., 1(1), 10-25. 2. rupprecht, c. e., smith, j. s., fekadu, m. and childs j. e. (1995). the ascension of wildlife rabies: a cause for public health concern or intervention? emerging infectious diseases, 1:107–114. 3. health organization: who expert consultation on rabies. who technical report series 981. geneva, switzerland, who. 2013. *grace o. olayemi e-mail: olamigracie@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e157, 2017 and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi and ghana was scared: media representations of the risk of an ebola outbreak in ghana iddrisu seidu head of research and programs, center for development and policy advocacy, box tl 1233, tamale, ghana abstract introduction: the 2014 ebola virus outbreak in parts of west africa marked the 25th occurrence of the disease since its discovery in 1976. while earlier outbreaks in central and eastern africa had limited geographical extension and little media coverage, news media interest in the 2014 epidemic was remarkably high. in countries like ghana, where the risk of imported infection was estimated to be among the highest, news coverage for the epidemic proliferated. this study aimed to describe and analyze the central themes which characterized media representations of the risk of ebola outbreak in ghana. method: a quantitative content analysis (ca) was employed to study news media reportage of the risk of ebola outbreak in ghana. two daily newspapers, the daily graphic and today were sampled. an online search for ebola news stories in the selected newspapers was conducted, and all hits with ebola downloaded and screened. a total of 332 articles were retrieved and 156 articles met the inclusion criteria. three independent coders carried out the coding using identical story analysis form. results: in the course of the 2014 ebola epidemic in parts of west africa, the daily graphic and today newspapers in ghana published 332 stories about the epidemic. of this number, the study analyzed 156 news articles which met the inclusion criteria. the analysis found that, media coverage for the risk of ebola outbreak in ghana reflected nine salient themes: concerns about the ghana’s preparedness, support for ghana’s preparation, public education on ebola virus, assurances on ghana’s readiness, suspected cases of ebola, effects of ebola, critique of ebola risk handling, misinformation and other. conclusion: analysis of news media coverage for the threat of ebola outbreak in ghana revealed nine important themes. these themes, contributed to an understanding of the broad impact of the recent ebola outbreak on various sectors of the population. key words: media coverage, ebola threat in ghana, epidemic preparedness, 2014 west africa ebola outbreak correspondence: saha.seidu1@gmail.com doi: 10.5210/ojphi.v10i2.9229 copyright ©2018 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. introduction the 2014 ebola virus disease (evd) outbreak in parts of west africa marked the 25th occurrence of the disease since its discovery in 1976 [1]. compared to all previous outbreaks mailto:saha.seidu1@gmail.com and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi combined, the recent evd epidemic was by far, the longest and largest [2]. from december 2013 when the first case was identified in the gueckedou district of guinea up till december 2014, over 9,800 estimated deaths were reported in guinea, liberia and sierra leon [3]. occurring in countries with fragile health structures, the epidemic epitomized a major catastrophe in the hardest-hit areas. while earlier outbreaks of evd in central and eastern parts of africa had limited geographical extension and little media coverage, news media interest in the 2014 ebola epidemic was remarkably high. the globalizing style of the virus, the extraordinary high cases and transmissions to cities with major international airports (i.e. lagos, freetown, conakry and monrovia) seemed plausible reasons. in ghana, where the risk of imported infection was estimated to be among the highest [4], news coverage for the epidemic heightened. news media perform a critical role in public health emergencies, when demand for accurate and timely information increases. they are also among the first-line receivers of risk information, and therefore occupy an important place in the social amplifications of risk [5]. even with the rise of social media, enabled by increased use of internet, computers and smart phones, the news media continue to be essential because many people have limited access to information from medical literature especially on diseases about which the public is unfamiliar [6]. when properly monitored and studied, statistics from news media can serve as feedback mechanism on emergency response intervention. data from either news or social media can also provide us with quantitative indicators of negative emotions (e.g. fear, anger, and anxiety) and positive sentiments (e.g. happiness and calm), which in turn could be useful in community engagement strategies [7]. equally, media misrepresentations of public health risk can lead to misinformation and public confusion. this, in relation to ebola, is significant because misinformation about the disease and its containment protocols has in times of outbreak, led to mistrust, resistance and hostilities from local people [8]. the record size of the 2014 epidemic seems to have renewed varied research interest on ebola virus. in a recent study, lee-kwan and colleagues [9] examined the cultural and community factors to safe burials of ebola victims. earlier in october, 2014, the international spreading risk of the outbreak to other parts of africa and beyond was similarly investigated [4]. a few others [10,11], have also studied the use of digital and culturally-centered health communication efforts in the context of the outbreak. despite these investigations, important gaps, nonetheless, exist in current knowledge. studies of public sentiments on ebola and perceptions of risk exposure expressed through the news media are lacking. the few attempts in this regard have focused largely on developed countries particularly, the us [12,13], whereas vast amount of data in west african countries remain understudied. this paper is the first to study the content of ghanaian newspapers’ coverage for the 2014 ebola outbreak. the study aims to describe and analyze the central themes which characterized media representations of the risk of ebola outbreak in ghana. method and sample: a quantitative content analysis (ca) was employed to study news media reportage of the risk of ebola outbreak in ghana following the 2014 ebola epidemic in parts of west africa. two daily newspapers, the daily graphic and today were sampled for the study. the daily graphic newspaper is the oldest in ghana and was purposively selected because it is widely read and has the highest daily circulation across the country. the selection of today in contrast was done by means of simple random sampling. an online search was conducted in the months of may and june, 2017 using key words including ‘ebola virus in 2014, ‘ghana’, ‘daily graphic’ and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi and ‘today newspaper’. all hits with ebola in the headline or in the main story were retrieved and screened to ensure that only articles from the selected newspapers were retained. the search in total retrieved 332 articles consisting of news, editorials, columns, and opinion articles. for inclusion, news articles needed to directly report on the threat of ebola in ghana; thus, news articles on different subjects about ghana which contained passing references to ebola were not included. the second criterion was that news articles needed to contain information about the risk of ebola in ghana which had been published after 31st december, 2013 and before january 31st, 2015. by these criteria, 172 articles were eliminated, leaving a final sample of 156 news articles for the study. this is illustrated in figure 1. figure 1: study flow chart coding an initial review of 50 randomly selected news articles by the author informed a categorization of the data into ‘general’ and ‘thematic’ categories. a complete coding manual was then developed to guide the process. coding for the general category included story type (news, editorial, column, and opinion), newspaper (daily graphic, today), news source (daily graphic, today, city fm, joy news, other) story length, month (january – december 2014). codes for the thematic category in contrast, comprised the following: ebola education, suspected cases of ebola in ghana, misinformation about ebola, concerns about ghana’s and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi preparedness, support for ebola prevention, critique of ebola risk handling, effects of ebola, assurances on ebola preparation and other. to guarantee inter-coder reliability, a detail story analysis form, which contained coders’ initials, the general and thematic categories was used to guide coders. three independent coders (the author and two graduates, who were given training prior to the exercise) carried out the coding, with codes by the author serving as control. inter-coder reliability test was performed by randomly selecting and double-coding 20% of the sampled news articles. cohen’s kappa for the thematic categories (article theme) was 0.71, while for the general categories, news source and news story type yielded inter-coder reliability scores of 0.91 and 0.85 respectively. data analysis data analysis was performed using spss version 20. descriptive statistics involving frequencies and percentages were run to describe the sampled article characteristics, and to allow for meaningful understanding of the data. results during the 2014 ebola virus outbreak in parts of west africa, the daily graphic and today newspapers in ghana published 332 stories about the epidemic. of the 156 news articles which met the inclusion criteria and were thus analyzed, the daily graphic newspaper, accounted for 40% of both newspaper type and primary source of newspaper stories on evd. today newspaper in contrast, contributed 60% of newspaper type, and 22% of primary source of newspaper story. the analysis in table 1 shows that today newspaper, compared to the daily graphic newspaper, published more secondary news on the epidemic. joy news (25%) and city fm (8%) were the common sources of ebola news for today newspaper besides itself (22%). the majority (83%) of ebola information in the news media was presented as news stories. a modest number of opinion articles (11.5%) also constituted a common source of ebola information while editorial and column news articles were the least forms of news media information on the epidemic. put together, media coverage for the threat of ebola virus outbreak in ghana reflected nine salient themes, defined in table 2. the analysis also found that, four of the nine identified themes accounted for over half (58%) of media reporting on ebola risk in ghana. these included concerns about the country’s preparedness (17%), support for ghana’s preparation for the outbreak (16%), public education on the virus (14%) and assurances on ghana’s readiness (11%). less dominant themes such as suspected cases of ebola in ghana and effects of the threat of ebola also had a regular reportage of 9.5% and 9% respectively. the results further showed that two themes: misinformation about ebola and critique of ebola risk handling had the smallest percentage coverage of 3.5% and 5.5% respectively. and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi table 1 news article characteristics n(156) % newspaper type daily graphic 62 39.7 today 94 60.3 news story type news 130 83.3 editorial 6 3.8 column 2 1.3 opinion articles 18 11.5 news original source daily graphic 62 39.7 today 34 21.8 joy news 39 25 city fm 13 8.3 other 8 5.1 table 2 definition of ebola news themes based on coverage theme definition 1. concerns about ghana’s preparedness messages in this theme included fears expressed by healthcare workers about their readiness to handle ebola patients; complaints about porous border control systems including but not restricted to lack of screening at entry points; worries about inadequate isolation and treatment centers; and reservations about some hospitals’ capacity to conduct ebola test 2. support for ebola preparation in ghana this comprised news stories on trainings for frontline health workers, material and logistical contributions to enhancing ghana’s preparation for the outbreak by the government, the corporate world, diplomatic community and development partners 3. ebola education this included news articles on sensitizations and public education on the ebola virus disease mode of spread, signs, symptoms, risk factors, prevention techniques, where and when to report for medical care 4. assurances on ebola preparation these were messages from political leaders and leadership of ghana’s health sector guaranteeing readiness for any eventuality 5. suspected cases of ebola in ghana this included news stories on suspected ebola infections in the country and laboratory test on alleged cases and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi 6. effects of ebola comprised news messages about the impact of the threat of ebola particularly on education, social life, entertainment, and business activities 7. critique of ebola risk handling news articles that criticize or commend the efficacy of response mechanisms vis-à-vis the threat of ebola 8. misinformation about ebola news stories about ebola virus diseases that contain medically incorrect statements about the disease, including traditional and religious claims on ebola treatment and prevention 9. other messages in this category included miscellaneous news stories about the virus including but not limited to conspiracy theories about ebola, travel warnings, calls for specific interventions etc. figure 2: monthly coverage of ebola of news, january december 2014 the regularity of the nine identified themes is illustrated in both figure 2 and table 3. the analysis showed that, by march, 2014, only 1 (0.6%) news story had been reported on support for ebola prevention in ghana. this coverage unsurprisingly, followed the formal recognition of the then evolving infection in parts of guinea as ebola virus. the month of april saw an increase in news coverage for the epidemic from just 1 in march to 10 (3.2%). while news coverage for the risk of the epidemic in ghana partly reflected crucial happenings in the worst affected countries, it is interesting to observe that the months of may and june had no coverage on any of the identified themes even though both cases and fatalities continued, particularly in june. from july, however, ghanaian media coverage for the epidemic witnessed marked increase to about 9%, peaked in august with 31.4% and declined significantly in september to about 19.9%. the decreasing coverage continued in october to about 19.2% 0 5 10 15 20 25 30 35 jan feb mar apr may jun jul aug sep oct nov dec 0 0 0.6 3.2 0 0 9 31.4 19.9 19.2 10.9 5.8 pe rc en ta ge month of coverage news coverage and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi through november (10.9%) to december (5.8%). compared to other months, august and september had news coverage on all the 9 themes while october and november had coverage on 8 themes each. coverage for concerns about ghana’s preparedness increased in july (4), peaked in september (12) and decreased considerably in october (3) and december (1). this perhaps explains a similar trend on coverage in respect of support for ebola readiness in ghana, which started in july (1) and increased consistently up to november (7) before diminishing to 3 in december. the results equally showed that news coverage for suspected imported cases of ebola virus into ghana was highest in july (7) and august (6), and almost disappeared in november (1) and december (1). this high reportage on suspected ebola cases in july and august, might have contributed to a corresponding surge in coverage for education on the contagion in the months of july (6) and august (6). other themes such as effects of the outbreak (9) and critique of ebola risk handling in ghana (5) were reported prominently in august, followed by significant declines in subsequent months. discussion this study is the first to analyze ghanaian news media’s coverage for the 2014 ebola epidemic in west africa. from obscurity in the first half of 2014, media coverage for the risk of ebola outbreak in ghana proliferated in july, and peaked in august. this watershed seems to have been heavily shaped by four external factors the swift increases in july/august caseload, the declaration of ebola as public health emergency of international concern, the exportation of ebola to nigeria on july 20th and the infection of two american workers in liberia, kent brantly and nancy writebol on july 27th. the results showed that, as media reporting of ebola risk in the country increased, nine major themes became salient and characteristic of the coverage. these included concerns about the ghana’s preparedness, support for ebola preparation, education on ebola, assurances on ghana’s readiness, suspected cases of ebola, effects of ebola threat, critique of ebola risk handling, misinformation about ebola and other. away from the usual research focus on ebola treatment and vaccine trials, the findings of this study contribute to an understanding of the broad impact of the recent ebola outbreak on various sectors of the population. while each of the identified themes may offer useful lessons for future occurrences, a few perhaps deserve further discussion. the finding that concerns on ghana’s preparation for the ebola virus was the leading theme in media coverage, requires policy attention. widespread concerns in an emergency situation can undermine public health surveillance. infected persons can abscond from isolation centers out of fear, and others may become hostile to emergency workers. a closer examination of this theme showed high prevalence of fear among the public and healthcare workers. in some instances, medical staff actually panicked in handling suspected ebola patients (today, 19/11), while in others, suspicious patients in dire need of medical attention were simply abandoned (today, 19/11). this result is similar to earlier findings in ethiopia, where abebe and colleagues [14] found ebola caused fears among more than 58% of healthcare professionals. it also concurs with previously reported episodes of fear, avoidance and flight from hospitals by medical staff in earlier outbreaks of ebola [8]. key among the drivers of ebola triggered concerns was general perception of weak epidemic preparedness in ghana. limited availability of personal protective equipment, porous borders and ghana’s struggle to contain an outbreak of cholera at the time [15], lent credence to the perceptions of weak preparedness. in one article for instance, the writer was alarmed that: ‘‘in 2014, cholera still remains an epidemic ghana has been unable to effectively combat and now, we have to deal with almighty ebola disease which we are told is the deadliest virus the world has ever seen’(today, 08/12). similar coverage by the daily graphic observed that ‘both the frontiers at aflao and northern ghana and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi are leaking badly so far as illegal entries are concerned. besides, those who enter are not screened before mingling with our indigenes; this is ... happening at a time the ebola scare is being magnified’ (daily graphic, 06/09). another interesting finding which perhaps involves positive lessons for ghana’s health system is the result that, news coverage of ebola threat in ghana had fewer instances of misinformation. the few misrepresentations about the epidemic were commonly centered on traditional and religious claims on the causes of ebola and treatment opportunities. while this tendency was helpful, it may have also been the result of a relatively high public education on the virus which started as early as april (5), stopped in may/june, and continued in july (6) up to december (3). since this analysis was limited to print media sources, it is also likely that public education on the virus was much higher than the present estimates. this finding on instances of misinformation on ebola, however, differs from analysis of ebola related misinformation on social media in guinea, liberia and nigeria in the first week of september 2014, which found that the majority of tweets (55.5%) and retweets (58.9%) on ebola contained medical misinformation [16]. this variation understandably, could be due to the gate keeping structures in mainstream media, which inter alia, can verify information prior to publication. while it is difficult to ascertain the true impact of the 2014 ebola crisis in non-infected countries such as ghana, media coverage on the effect of the ebola threat points to a wider impact on different sectors of the ghanaian society. the analysis showed that, the effect was positive for some sectors and negative for others. in the health sector for instance, the threat stimulated both short and long term investments in epidemic preparedness. these included but were not limited to emergency constructions of three new isolation centers and procurement of new medical equipment. other sectors such as education, was negatively impacted in respect of rescheduling of school periods, learning time lost to screening for ebola etc. the threat also lowered commodity prices for some goods e.g. game meat, and thus adversely affected the livelihoods of many ghanaians (daily graphic, 05/08; today, 15/08). game meat, known popularly as ‘bush meat’ is a delicacy in ghana, providing employment to many in the value chain (e.g. hunters, wholesalers, retailers, game meat kebab sellers and bar operators). although the game meat etiology of the recent outbreak has been contested [17], this effect seems logical given the risk of animal to human transmission of the deadly contagion. and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi table 3 frequency and percent of ebola news theme by month, january – december, 2014 recurring theme month of publication theme total percent percent of cases jan feb mar apr may jun jul aug sep oct nov dec concerns about preparedness 2 4 9 12 3 3 1 34 17% 21.8% support for ebola preparation 1 0 7 6 8 7 3 32 16% 20.5% education on ebola 5 6 6 2 4 2 3 28 14% 17.9% assurances on preparation 1 2 6 4 7 1 1 22 11% 14.1% suspected case of ebola in ghana 1 7 6 3 1 1 19 9.5% 12.2% effects of ebola 9 2 4 2 1 18 9% 11.5% critique of ebola risk handling 1 5 2 1 2 11 5.5% 7.1% misinformation about ebola 1 1 1 3 1 7 3.5% 4.5% other 11 8 7 3 29 14.5% 18.6% monthly total (%) 0.6% 3.2% 9% 31.4% 19.9% 19.2% 10.9% 5.8% and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi limitations this study notwithstanding its significance has several limitations. the study used data from only two print media outlets in ghana. this implies that ebola related discussions and perspectives shared through radio and television stations in ghana were not included. another important shortcoming of the study is the likelihood that the sampled news stories might not be representative due to the relatively high illiteracy rate in ghana; it is conceivable that the data for this study may reflect the sentiments of the well-educated, who unlike their illiterate counterparts, can express and share their experiences through the print media. finally, mainstream media publications compared with social media, have several gatekeeping structures which might modify or exaggerate individuals’ experiences and sensitivities to public health epidemics. conclusion media coverage for the risk of an ebola outbreak in ghana during the 2014 ebola epidemic was studied using quantitative content analysis. the study identified nine important themes which characterized media reporting of the epidemic: concerns about the ghana’s preparedness, support for ebola preparation, education on ebola, assurances on ghana’s readiness, suspected cases of ebola, effects of ebola threat, critique of ebola risk handling, misinformation about ebola and other. these themes provided valuable understanding on public responses to the threat and its widespread impact on the ghanaian society. it is significant to recognize that while vaccinations and medical treatments are helpful ways of controlling infectious disease outbreaks, they probably would not be the most effective way to approach unfamiliar infections. the biggest resources for containment of deadly epidemics of ebola’s kind are robust surveillance and containment capacity, including well-equipped medical staff, with reasonable protection against the perils of working with diseases of highcase fatality. the extensive impact of ict in this day and age will be helpful in building robust response mechanisms in ghana. these could be ehealth tools designed to facilitate community mobilization, logistics management, contact tracing and timely data collection. with a high smartphone penetration rate in ghana, the use of ehealth tools will effectively situate the country to move beyond facility-based disease surveillance, to digitally driven participatory engagement of populations at risk. further research on how ict based surveillance strategies involving media and mobile data platforms can strengthen ghana’s surveillance capacity will be useful. conflict of interest i declare that there is no conflict of interest. references 1. 2014. the lancet infectious diseases. ebola in west africa [editorial]. lancet. (sep), 14. 2. briand s, bertherat e, cox p, et al. 2014. the international ebola emergency. n engl j med. 371, 13. pubmed https://doi.org/10.1056/nejmp1409858 3. who.2015. ebola situation report. who 4th march, 2015 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25140855&dopt=abstract https://doi.org/10.1056/nejmp1409858 and ghana was scared: media representations of the risk of an ebola outbreak in ghana online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e203, 2018 ojphi 4. gomes mfc, piontti ap, rossi l, et al. 2014. assessing the international spreading risk associated with the 2014 west african ebola outbreak. plos currents outbreaks. 1. doi:10.1371/currents.outbreaks.cd818f63d40e24aef769dda7df9e0da5. pubmed 5. kasperson re, renn o, slovic p, et al. 1988. the social amplification of risk: a conceptual framework. risk anal. 8, 2. https://doi.org/10.1111/j.1539-6924.1988.tb01168.x 6. chapman s, lupton d. fight for public health: principles and practice of media advocacy. london: british medical journal publishing, 1994 7. chun-hai fung i, hos tse zt, cheung c, miu as, fu k. 2014. ebola and the social media. lancet. •••, 384. pubmed 8. sokol dk. from anonymity to notoriety. historical problems associated with outbreaks of emerging infectious diseases; a case study: ebola hemorrhagic fever. master degree thesis in social and economic history. university of oxford, 2002 9. lee-kwan hs, deluca l, bunnell r, et al. facilitators and barriers to community acceptance of safe, dignified medical burials in the context of an ebola epidemic, sierra leone, 2014, j health commun 2017; 22: sup1, 24-30. doi: 10.1080/10810730.2016.1209601 10. sastry s and dutta jm. health communication in the time of ebola: a culture-centered interrogation. j health commun 2017; 22:sup1, 10-14. doi: 10.1080/10810730.2016.1216205 11. roberts h, seymour b, fish ii as, robinson e and zuckerman e. digital health communication and global public influence: a study of the ebola epidemic. j health commun 2017; 22:sup1, 51-58. doi: 10.1080/10810730.2016.1209598 12. towers s, afzal s, bernal g, et al. 2015. mass media and the contagion of fear: the case of ebola in america. plos one. 10(6), e0129179. doi:https://doi.org/10.1371/journal.pone.0129179. pubmed 13. basch ch, basch ce, redlener i. 2014. coverage of the ebola virus disease epidemic in three widely circulated united states newspapers: implications for preparedness and prevention. health promot perspect. 4(2), 247-51. doi:10.5681/hpp.2014.032. pubmed 14. abebe bt, bhagavathula as, tefera yg, et al. 2016. healthcare professionals’ awareness, knowledge, attitude, perceptions and beliefs about ebola at gonder university hospital, northwest ethiopia: a cross-sectional study. j public health africa. 7, 570. pubmed https://doi.org/10.4081/jphia.2016.570 15. who. 2014. situation report on cholera outbreak in ghana. who, 2 november, 2014 16. oyeyemi os, gabarron e, wynn r. 2014. ebola, twitter, and misinformation: a dangerous combination? bmj. 349, g6178. doi:https://doi.org/10.1136/bmj.g6178. pubmed 17. gire sk, goba a, andersen kg, et al. 2014. genomic surveillance elucidates ebola virus origin and transmission during the 2014 outbreak. science. 345, 1369-72. doi:https://doi.org/10.1126/science.1259657. pubmed https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25642360&dopt=abstract https://doi.org/10.1111/j.1539-6924.1988.tb01168.x https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25625391&dopt=abstract https://doi.org/10.1371/journal.pone.0129179 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26067433&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25649411&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28299161&dopt=abstract https://doi.org/10.4081/jphia.2016.570 https://doi.org/10.1136/bmj.g6178 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25315514&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25315514&dopt=abstract https://doi.org/10.1126/science.1259657 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25214632&dopt=abstract and ghana was scared: media representations of the risk of an ebola outbreak in ghana introduction method and sample: coding data analysis results discussion limitations conclusion conflict of interest references layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts development of automated data quality indicators and visualizations using florida’s essence system wayne loschen*1 and aaron kite-powell2 1johns hopkins university applied physics laboratory, laurel, md, usa; 2florida department of health, jacksonville, fl, usa objective the objective of this project was to develop visualizations and tools for public health users to determine the quality of their surveillance data. users should be able to determine or be warned when significant changes have occurred to their data streams, such as a hospital converting from a free-text chief complaint to a pick list. other data quality factors, such as individual variable completeness and consistency in how values are mapped to standard system selections should be available to users. once built, these new visualizations should also be evaluated to determine their usefulness in a production disease surveillance system. introduction understanding your data is a fundamental pillar of disease surveillance success. with the increase in automated, electronic surveillance tools many public health users have begun to rely on those tools to produce reports that contain processed results to perform their daily jobs. these tools can focus on the algorithm or visualizations needed to produce the report, and can easily overlook the quality of the incoming data. the phrase “garbage in, garbage out” is often used to describe the value of reports when the incoming data is not of high quality. there is a need then, for systems and tools that help users determine the quality of incoming data. methods a series of data quality visualizations were developed and implemented in the florida department of health’s version of essence. users were given numerous pages that showed different aspects of data quality, such as variable-level percent completeness measurements shown by hospital or county. other items included the percent of time a value that should have been a part of a specific reference list was actually present and matched to known values, the number of input files received by a hospital, and the time each data source was processed. finally, an algorithm and visualization was developed to alert users when data quality factors had changed significantly. with access to all these new screens, users of the system were given the opportunity to use the system and their usage and opinions were collected. results the data quality portal has been active the florida essence system since march 31st, 2012. between that time and august the portal has been accessed over 1300 times. the presentation will include additional statistics about which specific features were most used and those features that users have found the most useful. in addition, data quality issues that have been discovered using the new tool will be discussed. conclusions with the ever increasing amount of data that public health must analyze due to meaningful use, it is imperative that tools and visualizations that can decipher data quality issues be made available in an easily accessible format and without the need for tools external to the system. if systems continue to ignore changes in the data they receive automatically, it can easily produce degraded or incorrect analyses and interpretation of events, leading to wasted resources. these results can negatively impact the decisions and responses that public health users make, especially in light of the increasing reliance on these types of systems for up to the minute information. this project has developed tools and visualizations that can help determine the data quality issues as they are occurring. this presentation will outline the lessons learned for using and creating these tools so they can be shared for everyone to benefit. keywords visualization; data quality; meaningful use *wayne loschen e-mail: wayne.loschen@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e17, 2013 a virtual data repository stimulates data sharing in a consortium 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi a virtual data repository stimulates data sharing in a consortium suzanne siminski1*, soyeon kim1, adel ahmed1, jake currie1, alex benns1, amy ragsdale2, marjan javanbakht2, pamina m. gorbach2, and the c3pno cohort investigators. 1frontier science foundation, amherst, ny and brookline, ma 2university of california los angeles, los angeles, ca abstract research data may have substantial impact beyond the original study objectives. the collaborating consortium of cohorts producing nida opportunities (c3pno) facilitates the combination of data and access to specimens from nine nida-funded cohorts in a virtual data repository (vdr). unique challenges were addressed to create the vdr. an initial set of common data elements was agreed upon, selected based on their importance for a wide range of research proposals. data were mapped to a common set of values. bioethics consultations resulted in the development of various controls and procedures to protect against inadvertent disclosure of personally identifiable information. standard operating procedures govern the evaluation of proposed concepts, and specimen and data use agreements ensure proper data handling and storage. data from eight cohorts have been loaded into a relational database with tables capturing substance use, available specimens, and other participant data. a total of 6,177 participants were seen at a study visit within the past six months and are considered under active follow-up for c3pno cohort participation as of the third data transfer, which occurred in january 2020. a total of 70,391 biospecimens of various types are available for these participants to test approved scientific hypotheses. sociodemographic and clinical data accompany these samples. the vdr is a web-based interactive, searchable database available in the public domain, accessed at www.c3pno.org. the vdr are available to inform both consortium and external investigators interested in submitting concept sheets to address novel scientific questions to address high priority research on hiv/aids in the context of substance use. keywords: common data elements, data repository abbreviations: national institute on drug abuse (nida), collaborating consortium of cohorts producing nida opportunities (c3pno), human immunodeficiency virus (hiv), acquired immunodeficiency syndrome (aids), injecting drug users (idu), virtual data repository (vdr) correspondence: siminski@frontierscience.org* doi: 10.5210/ojphi.v13i3.10878 copyright ©2021 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged i n the copy and the copy is used for educational, not-for-profit purposes. mailto:siminski@frontierscience.org* a virtual data repository stimulates data sharing in a consortium 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi introduction research data are undeniably a valuable resource, requiring considerable effort, time, and funding to produce. by increasing access to research data, the “impact, efficiency, and effectiveness of scientific activities and funding opportunities” are also increased [1]. affirming its commitment to access to data generated through support of public funds, the national institutes of health (nih) issued a statement requiring a plan for data sharing for investigator-initiated applications [2]. the rationale for the requirement is that [s]haring data reinforces open scientific inquiry, encourages diversity of analysis and opinion, promotes new research, makes possible the testing of new or alternative hypotheses and methods of analysis, supports studies on data collection methods and measurement, facilitates the education of new researchers, enables the exploration of topics not envisioned by the initial investigators, and permits the creation of new datasets when data from multiple sources are combined.3 in order to leverage investments in publically-funded research such as ongoing cohorts that address high priority research on hiv in the context of substance use, the national institute on drug abuse (nida) issued rfa-da-17-019 to solicit cooperative agreement applications “to establish a virtual repository, and facilitate the leadership of the cohorts steering committee (sc), consisting of representatives from the nida-funded cohorts and nida staff” in order to “provide a strong resource platform for current and future collaborative efforts with other investigators to address emerging questions related to hiv pathogenesis, prevention, and treatment in the context of substance abuse, as well as to foster the creativity and efficiency of investigator–initiated research projects.” [3] the goal is not only to optimize collaborations among cohort investigators but also to provide better access to data and specimens for researchers external to the cohorts. the collaborating consortium of cohorts producing nida opportunities (c3pno) [4] was funded to facilitate broader access to rich data and biological specimens from the nine nidafunded cohorts described in table 1. an important activity of the consortium has been the creation of a virtual data repository (vdr). a vdr is an online repository of data. a vdr facilitates information sharing within and beyond narrowly defined research communities. by access through an online interactive platform, a vdr can allow a user to define search criteria and obtain a summary of the number of participants meeting the criteria. a vdr may include information such as concise data descriptions displayed in the form of a master data catalog, provide details on the populations who contributed the data, and facilitate disseminating information to the interested users of the data and users of well-characterized banked specimens. by making a vdr available in the public domain, users are able to triage the appropriateness of the data for their purposes without having to make a formal request to each of the study teams for information. by coordinating efforts and providing access to data and specimens across cohorts, data may have substantial value beyond that of addressing the original research studies’ objectives. the most obvious value of combining data across cohorts is the greater sample size it affords, thereby increasing power to test hypotheses, which is particularly important in smaller populations or when events of interest are rare, for example, hiv seroconversion. in addition, research consistent with a virtual data repository stimulates data sharing in a consortium 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi nida’s mission may be outside the expertise of the cohorts’ investigators and providing broad access to data and specimens to researchers from other disciplines, including new investigators, may facilitate the establishment of new knowledge bases. because the specimens come from wellcharacterized individuals, they are particularly valuable for assessing biomarkers. it is worthwhile to note that the nine cohorts above were established independently, span nearly 20 years in dates of inception, and are funded separately. each cohort has its own leadership structure and addresses different nida priorities. each cohort has distinct study aims, research objectives, study populations, specimens, and data, and each stores data in separate formats. to take advantage of c3pno cohorts’ unique opportunity to study the intersection of substance use and hiv to answer questions in key populations, otherwise not possible with a single cohort’s data, requires that certain challenges be overcome. we address these challenges by marshalling a multidisciplinary team with expertise in data curation and mapping, epidemiology, bioinformatics, data standardization, and data linking. table 1: overview of cohorts cohort population year started no. of study participants access hiv-positive pwid 2005 1100 alive pwid 1988 1500 heart study hiv-positive african americans 2004 1400 hym young men of color who have sex with men 2015 450 jhhcc hiv-positive persons in receiving care through johns hopkins hiv/aids services ambulatory clinics 1989 1100 mash hispanic persons in south florida 2002 1400 mstudy latino and african-american/black men msm at ucla vine street clinic 2013 500 radar young msm 2014 1100 v-dus hiv-negative pwid 1996 3500 *abbreviations: no., number; hiv, human immunodeficiency virus; pwid, persons who inject drugs; aids, acquired immunodeficiency syndrome; msm, men who have sex with men; ucla, university of california los angeles. the cohorts and coordinating center the consortium of cohorts are described elsewhere [4]. briefly, the cohorts geographically span the united states and canada and include: the aids care cohort to evaluate access to survival services (access) study (vancouver, canada); aids linked to the intravenous experience (alive) study (baltimore, md); the heart study (baltimore, md); the healthy young men’s (hym) study (los angeles, ca); the johns hopkins hiv clinical care cohort (jhhcc) (baltimore, md); the miami adult hiv (mash) study (miami, fl); mstudy (los angeles, a virtual data repository stimulates data sharing in a consortium 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi ca); radar (chicago, il); and the vancouver drug users study (v-dus) (vancouver, canada). the cohorts follow hiv-positive and high risk hiv-negative persons, people who use drugs including persons who inject drugs (pwid), and men who have sex with men (msm) in either community or clinical settings. they include participants in and out of hiv care and substance use treatment. some cohorts focus specifically on adolescents and young adults. all follow participants longitudinally. the cohorts collect extensive demographic, behavioral, clinical, and laboratory assay-based information on study participants. the differing study objectives of the cohorts result in heterogeneous populations and thus various types of data collected, ultimately leading to a lack of common standards across cohorts. even when data domains align, instrument selection may be tailored to the population or to best serve the original studies’ aims. c3pno, among other functions, has developed and maintains a vdr which is described herein. methods common data elements (cdes) the c3pno steering committee, composed of the cohorts’ principal investigators, nida scientific staff, and a scientific advisory board, developed an initial list of high-priority cdes, which were selected based on their perceived importance for defining study populations, risk factors, potential confounders, or outcomes for assessing the feasibility of a wide range of research proposals addressing high priority research domains. because some cohorts have been in existence for decades while others were established in the last five years and because some data elements are captured repeatedly and can vary with time (e.g., participant age, cd4+ counts, hiv/hcv viral loads, substance use patterns, sexual behaviors), the initial focus of this effort was on the most recent full visit for a participant. as such, not all participants currently or ever enrolled in the cohorts are represented in the available repository data, but it does ensure that all the data represent an up-to-date snapshot of cohort participants. the first data submission transfer in may 2018 included general demographic, socioeconomic, substance use, behavioral, and hiv related data from cohort participants. the first submission allowed the consortium’s data staff to learn about cohorts’ data management systems, obtain data dictionaries and/or data catalogues, establish data transfer agreements, and comply with any institutional regulatory requirements. with the first transfer, we also established processes for data transfer, data mapping, and conversion to a common format. this process allowed us to establish rapport between the coordinating center staff and cohort pis and data managers. multiple discussions, including an initial on-site, face-to-face meeting, followed by emails and teleconferences assisted in resolving any pending issues. not all cdes are collected by all nine cohorts, and data elements collected by multiple cohorts were not standardized across the cohorts. some cohorts collected a data element with finer granularity than others. initially data mapping to a common format was performed centrally by the c3pno coordinating center, and mapping and final tabulations of cdes were reviewed with data managers and cohort pis for accuracy. in the case that additional data were submitted by the cohort data center, only data that are part of the cde were mapped. data transfer, transformation, updates, and retention in order to minimize burden, data were submitted by cohorts in a format convenient to the cohort data team and in single or multiple files, although future data transfers are expected to be submitted in the format used for the initial transfer. a secure web-based file sharing system is used to submit a virtual data repository stimulates data sharing in a consortium 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi data. each user has a password protected account and access limited to that user’s cohort directory. datasets are transformed using a commercial extract-transform-load (etl) system. each cohort has its own transformation which can be run independently, and is tested and validated to ensure data integrity. all cde records are retained per regulatory requirements, but when new data are submitted, previous submissions are flagged as inactive. this allows a clear delineation of what data was available at any point in time, and, if needed, the data can be rolled back to a previous version. in the most recent data transfer, data was expanded to include longitudinal data. data mapping was performed by the data team of each individual cohorts based on mapping guide provided by the coordinating center. the cohort data team performs the mappings and submits the data to the coordinating center with documentation of the mappings. the database data are stored in a commercial relational database and, key fields are linked across tables. database constraints are defined to enforce data integrity. it is expected that future data requests will expand the data included in the cde set. the structure of the database is flexible so that new data elements can be easily incorporated. participant data are stored in three normalized database tables. the core participant database table (cohortparticipantdataitem) holds demographic, socioeconomic, clinical, and sexual behavior data, e.g., sex at birth, age, income, weight, hemoglobin, number of male sex partners. there is one record per participant data item (multiple per participant), which allows for the inclusion of additional data items as the cde is expanded with subsequent data transmissions without changing the original database structure. while substance use and biospecimen data could have been included in a single table, this would have required additional complexity not needed for both types of data. for both substance use and biospecimen data, it was determined that data were specialized to such a degree that it would be more efficient to maintain a separate database table for each. the substance use database table (cohortparticipantsubstanceuse) has fields for specific drug, reporting method, and administration route. data on available biospecimens are stored in another database table (cohortparticipantbiospecimen) which likewise contains fields for number of aliquots, specimen type, additive, and derivative type. vdr investigators can use the interactive platform to determine the number of participants and specimens that are available for their potential research study. filters are utilized to allow the user to specify inclusion criteria for their study population. for example, the user can determine how many male hiv-positive people reporting use of heroin are in each c3pno cohort and the number and type of specimens available for cohort participants meeting the inclusion criteria. importantly, no individual participant-level data are displayed; only summary counts of the number of total participants and of each biospecimen type meeting the specified criteria are shown. in addition to counts, the results page displays the specified search criteria used in generating the tabulations for the benefit of the end user. more complex searches can be obtained by working with the c3pno coordinating center. a virtual data repository stimulates data sharing in a consortium 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi bioethics experts were consulted in the development of procedures to protect against inadvertent disclosure of personally identifiable information by allowing researchers to perform queries on the database on the interactive platform. for example, query results are not displayed if fewer than ten participants are included in a given category. if a search results in less than ten participants for a specific cohort, data are only displayed collapsed across cohorts and only when the minimum required numbers are displayed in the query result. results table 2 shows a sampling of key types of demographic and clinical data and table 3 shows a sampling of substance use data available at the www.c3pno.org website. data from 6,177 participants represent cohort participants who have been seen at the last full visit. additional data for approximately 3,000 more participants in the canadian cohorts, (access and v-dus) will be available once participants are re-consented to allow their data to be shared with the consortium. currently, a small fraction of participants from the v-dus cohort have had an opportunity to provide their consent at a study visit. a virtual data repository stimulates data sharing in a consortium 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi table 2: number of participants with a recent full visit contributing specific data elements in c3pno virtual data repository (c3pno.org january 27, 2020) cohort: alive heart hym jhhc c mas h mstudy rada r vdus total total participants 1328 580 400 948 1016 560 1030 315 6177 demographics sex at birth 1328 580 400 948 1016 560 1030 315 6177 transgender status * * 400 948 1016 * 1030 315 3709 race 1328 580 397 948 1016 547 1030 302 6148 ethnicity (hispanic or non-hispanic) 1328 580 400 948 1016 547 1030 302 6151 homelessness 1328 * 400 * 49 10 19 314 2120 incarceration * * 398 * 1012 545 1030 315 3300 health care health insurance 1324 * 400 * 975 525 913 * 4137 accessed health care past 6 month status 1328 † 298 † 1015 546 666 315 4168 hiv-related hiv status 1328 580 400 948 992 560 1030 315 6153 antiretroviral treatment 372 406 66 942 480 * 209 * 1995 cd4 count (cell/mm3) 372 368 65 948 475 281 95 * 2604 hiv-1 viral load (copies/ml) 374 371 65 948 474 284 79 * 2595 other testing/ diagnoses hepatitis b status 1284 * 313 * 1015 81 * 315 3008 hepatitis c status 1327 * 313 942 1016 * * 313 3911 tuberculosis * * 948 * * * * 948 chlamydia * * 386 * * 544 1021 315 2266 gonorrhea * * 386 * * 544 1023 315 2268 syphilis * * 384 * * 143 * 315 842 abbreviations: hiv, human immunodeficiency virus; cohort. *no data of this specific type were reported by the cohort as available for use. †heart and jhhcc studies are clinical cohorts so all participants are in care. a virtual data repository stimulates data sharing in a consortium 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 ojphi table 3: number of participants with a recent full visit with data on drug usage, either by self-report within the last 6 months or by urinalysis (c3pno.org january 27, 2020)* cohort: alive heart hym jhhcc mash mstudy radar v-dus total total participants 1328 580 400 948 1016 560 1030 315 6177 cocaine self-report 1321 580 400 428 1014 545 1030 315 5633 urinalysis 0 0 356 440 1012 559 1027 254 3648 heroin self-report 1321 580 400 63 1015 545 1030 315 5269 urinalysis 0 0 356 47 1008 559 1027 0 2997 methamphetamines self-report 0 0 400 74 1016 545 1030 315 2364 urinalysis 0 0 356 47 1011 559 1027 0 3000 prescription pain killers self-report 1321 0 399 0 1012 196 1030 315 4273 urinalysis 0 0 0 404 0 0 0 254 658 fentanyl self-report 0 539 0 8 1014 349 0 315 2225 urinalysis 0 0 0 56 997 398 0 254 1705 cannabis self-report 1321 580 400 486 1015 545 1030 315 5692 urinalysis 0 0 356 439 1011 559 1027 254 3646 alcohol (self-report) 0 553 400 942 1016 0 1030 315 3736 nicotine (self-report) 1319 580 114 614 1014 0 0 315 3956 speedball (self-report) 1321 577 0 0 0 0 0 289 2187 hallucinogen (self-report) 1321 0 400 70 1014 0 1030 0 3835 stimulants (self-report) 1321 0 400 22 1015 0 1030 293 4081 * when a cohort did not collect drug usage data by a method they are reported in the table as 0. a virtual data repository stimulates data sharing in a consortium 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 data elements include race, sex, substance use, clinical history, and sexual behavior, and additional elements can be added with each update – refer to the c3pno.org website for data currently available. as some of the cohorts follow men who have sex with men (msm) only, there are more participants who report male sex at birth than female overall (72% and 28%, respectively). at last visit, approximately 61% are black/african american, 18% are hispanic, and nearly half are hivpositive. all cohorts include assessments of self-reported recent substance use at each study visit, but the substances assessed varied across the cohorts (see table 3). in the last data transfer, all cohorts assessed cocaine use; eight cohorts assessed heroin use; six cohorts assessed methamphetamine use; six cohorts assessed prescription pain medication use; and eight cohorts assessed cannabis use. urinalysis results for toxicological screens for substance use are also available in some cohorts for some substances. table 4 highlights the numbers of participants with a recent full visit who have biospecimens available by each cohort by type. plasma is available on 68%, serum on 47%, and pbmcs on 37% of participants. for some cohorts, additional biospecimens are available, including whole blood, oral rinse, passive drool, rectal swabs and sponges, nail, hair, buffy coat, and pellet specimens. investigators can propose research using these biospecimens for consideration by the c3pno steering committee. table 4: number of participants with a recent full visit for whom biospecimens are available (c3pno.org january 27, 2020). cohor t alive hear t hym jhhcc mas h mstud y rada r vdus tota l total participa nts 1328 580 400 948 1016 560 1030 315 6177 pbmc 386 * * 690 1016 184 17 * 2293 plasma 925 566 * 730 1016 184 755 * 4176 serum 695 * * 678 1016 490 * * 2879 buffy coat * * * 568 * * * * 568 whole blood * * * * 1016 * * * 1016 hair * * * * * 187 * * 187 nail * * * * * 412 * * 412 oral rinse * * * * * 452 * * 452 passive drool * * * * * 490 * * 490 pellets * * * * * 183 * * 183 rectal sponge * * * * * 123 * * 123 rectal swab * * * * * 489 778 * 1267 abbreviations: pbmc, peripheral blood mononuclear cells. * no biospecimens of the specific type were reported by cohort as available for use. subject to minimum threshold requirements (to guard against any potential unintentional disclosure of identifying information), the number of biospecimens from individuals meeting specific criteria can be obtained by adding filters. for example, the vdr can provide a tally of the number of plasma specimens from hiv-positive persons who have cd4+ cell counts less than 200 cells/mm [5]. a virtual data repository stimulates data sharing in a consortium 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 we previewed the c3pno vdr at a preconference for the 22nd international aids conference (aids 2018), and have disseminated availability of data and specimens through nida, international workshop on hiv and hepatitis observational databases (iwhod), 25th scientific conference of the society on neuroimmune pharmacology (snip), and additionally through links on a growing number of websites. limitations questionnaires were designed by each cohort team to best suit their population and study objectives. this results in heterogeneity in measures available for the cohorts. for example, substance use recall periods and assessment of frequency of use are not uniform across cohorts. the c3pno consortium is currently conducting projects to allow data linking of drug use and other key data measures to facilitate cross-cohort analyses. conclusions the benefits of data sharing are readily acknowledged by researchers, including those participating in the c3pno consortium. data linking work to address the use of different data instruments and to address differing definitions across cohorts for analytic purposes is ongoing. cross-cohort analyses are in various stages of planning and execution. a number of other nih-funded consortia have also created vdrs to improve access to their data and specimens. the vdrs differ in the types of data and populations that are housed. the nih is taking a leadership role in funding and requiring participation in vdr efforts. in the context of hiv treatment and prevention, the actg (aids clinical trials group), impaact (international maternal pediatric adolescent aids clinical trials network), and hvtn (hiv vaccine trials network) have developed a combined vdr that allows an investigator to perform an interactive search to learn about the specimens available (http://www.specimenrepository.org). the vdr allows filtering on the types of study and participant characteristics. concept proposals are sent to specific network for their review. while conceptually the hiv vdr is similar to the c3pno vdr, the populations and key data elements differ. the i2b2 (informatics for integrating biology & the bedside) now n2c2 (national nlp clinical challenges) clinical research platform for precision medicine is a nih-funded research platform that makes clinical data in electronic health records into analyzable data by using natural language processing to make unstructured text into data sets (i2b2.org). software is available to run queries and transmart tools are available for use in data exploration, display and analysis (https://i2b2transmart.org). these and other vdrs share the benefit of reducing the effort and time required by a researcher to a minimum for determining the feasibility of many concepts. the vdrs differ in the provenance of and type of data available which are tailored to the specific populations that are of interest. they may also have associated specimens that can be used for running assays. it is necessary for external researchers to be aware that such cohorts exist in order to enhance utilization of the data. furthermore, external researchers and those across the c3pno consortium need access to the characteristics of the study population, data collection methods, and a virtual data repository stimulates data sharing in a consortium 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 storage/types of specimen in order to develop research proposals and plan analyses. for some research questions, data from multiple cohorts must be combined to have sufficient power. a vdr can facilitate the process. the advantages of a vdr in the public domain are numerous, perhaps the greatest being the enhanced ability to promote collaborative science through curated data sharing. data sharing and transformation is a critical step in ensuring that existing data can be used in additional research studies. the barriers to data sharing are being overcome by transforming information collected into a set of cdes for the purpose of vdr display. the c3pno vdr is available to inform consortium and external investigators interested in submitting concept sheets for research proposing to use consortium data for consideration by c3pno. a system is in place to streamline the submission of concept sheets, and to track the review, data use agreement, data and/or specimen transmission, and publication process. these data can be further utilized by other investigators for scientific inquiry. acknowledgements first and foremost, we are most grateful for the involvement of our cohort participants for making this research possible. it is their time, commitment and involvement that allows us to collect the necessary data to draw meaningful scientific conclusions and advance our collective research via the consortium. we thank the c3pno cohort principal investigators (pi) and data managers (dm) for their leadership, expertise, and technical contributions to the consortium. in alphabetical order by cohort: access: pi, m-j milloy, dms, wing yin (janet) mok and ekaterina nosova; alive: pis, greg kirk and shruti mehta, dms, jacquie astemborski and todd noletto; hym: pi, michele kipke, dms, julia moore, ji hoon ryoo, and su wu; heart study: pi, shenghan lai, dm, shaoguang chen; jhhcc: pi, richard moore, dms, jeanne keruly, steven xu, li ming zhou, and charles collins; mash: pi, marianna baum, dm, qingyun liu; mstudy: pis, pamina gorbach and steven shoptaw; dms, india richter, fiona whelan, shahrzad divsalar, alexander moran, allison rosen, and stone shih; radar: pi, brian mustanski, dms, antonia clifford, daniel ryan and kitty buehler; and v-dus: pis, kora debeck and kanna hayashi, dms, wing yin (janet) mok, and ekaterina nosova. lastly, we thank the additional members of the frontier science technical team; david goss, astrid fuentes, lynn strusa and kris ricusso. this project is supported by the national institute of drug abuse (nida) of the national institutes of health under award numbers: u24da044554, u01da0251525, u01da036297, u01da036926, u01da040325, u01da036935, u01da040381, u01da036267, u01da036939, 2u01da038886. additional information about each c3pno cohort can be found at www.c3pno.org including objectives, current research, contact information, and links to cohort specific websites. financial disclosure no financial disclosures. competing interests no competing interests. http://www.c3pno.org/ a virtual data repository stimulates data sharing in a consortium 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e19, 2021 references 1. lee dj, stvilia b. 2017. practices of research data curation in institutional repositories: a qualitative view from repository staff. plos one. 12, e0173987. pubmed https://doi.org/10.1371/journal.pone.0173987 2. final nih statement on sharing research data. 2003. (accessed august 27, 2019, at https://grants.nih.gov/grants/guide/notice-files/not-od-03-032.html.) 3. rfa-da-17-019 coordinating center for the hiv/aids and substance use cohorts program (u24). at https://grants.nih.gov/grants/guide/rfa-files/rfa-da-17-019.html.) 4. gorbach p, siminski s, ragsdale a, javanbakht m, kim s, chandler r. cohort consortium profile: the collaborating consortium of cohorts producing nida opportunities (c3pno). 2019. 5. nih announces draft statement on sharing research data. 2002. (accessed august 27, 2019, at https://grants.nih.gov/grants/guide/notice-files/not-od-02-035.html.) https://pubmed.ncbi.nlm.nih.gov/28301533 https://doi.org/10.1371/journal.pone.0173987 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts potential use of multiple surveillance data in the forecast of hospital admissions objective this paper describes the potential use of multiple influenza surveillance data to forecast hospital admissions for respiratory diseases. introduction a sudden surge in hospital admissions in public hospital during influenza peak season has been a challenge to healthcare and manpower planning. in hong kong, the timing of influenza peak seasons are variable and early short-term indication of possible surge may facilitate preparedness which could be translated into strategies such as early discharge or reallocation of extra hospital beds. in this study we explore the potential use of multiple routinely collected syndromic data in the forecast of hospital admissions. methods a multivariate dynamic linear time series model was fitted to multiple syndromic data including influenza-like illness (ili) rates among networks of public and private general practitioners (gp), and school absenteeism rates, plus drop-in fever count data from designated flu clinics (dfc) that were created during the pandemic. the latent process derived from the model has been used as a measure of the influenza activity [1]. we compare the cross-correlations between estimated influenza level based on multiple surveillance data and gp ili data, versus accident and emergency hospital admissions with principal diagnoses of respiratory diseases and pneumonia & influenza (p&i). results the estimated influenza activity has higher cross-correlation with respiratory and p&i admissions (!=0.66 and 0.73 respectively) compared to that of gp ili rates (table 1). cross correlations drop distinctly after lag 2 for both estimated influenza activity and gp ili rates. conclusions the use of a multivariate method to integrate information from multiple sources of influenza surveillance data may have the potential to improve forecasting of admission surge of respiratory diseases. table 1. cross correlations between the estimated influenza activity based on the multivariate dynamic linear model, gp ili rate versus a&e respiratory diseases and p&i admissions *negative lags refer to correlations between lagged surveillance data and hospital admissions keywords influenza; surveillance; admission; respiratory references lau eh, cheng ck, ip dk, cowling bj. situational awareness of influenza activity based on multiple streams of surveillance data using multivariate dynamic linear model. plos one 7(5): e38346. doi:10.1371/journal.pone.0038346 *eric h. lau e-mail: ehylau@hku.hk eric h.y. lau*¹, dennis k.m. ip¹ and benjamin j. cowling¹ ¹school of public health, the university of hong kong, hong kong online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e168, 2013 lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi lyme disease in maine: a comparison of nedss surveillance data and maine health data organization hospital discharge data sara robinson1 1. maine center for disease control and prevention and university of illinois at chicago abstract background: lyme disease is the most commonly reported vector borne disease in the united states and is a major public health concern in maine. maine center for disease control and prevention (maine cdc) monitors lyme disease through a passive surveillance system. in order to validate the lyme disease surveillance system, maine cdc was interested in comparing trends with a secondary data source. specifically, maine cdc was interested in comparing trends by age group, gender, geography, and timelines. also, because hospitalization due to lyme disease is rare, this analysis provided an opportunity to look at the diagnosis codes used for lyme disease visits. the purpose of this paper is to compare the data acquired through surveillance to a secondary data source in order to evaluate the completeness of the data and verify trends. methods: surveillance data was extracted from maine’s nedss base system for the years 2008 – 2011. only confirmed and probable cases were included in data analysis. the maine health data organization (mhdo) collects information on all hospital inpatient and outpatient data visits and was used for this comparison. mhdo inpatient and outpatient hospital encounters with a diagnosis of 08881 in any diagnosis field were extracted from the full dataset from 2008 – 2011. results: surveillance data showed the 5-14 year old age group had the highest rates of lyme disease while outpatient data showed adults over the age of 45 to have the highest rates. outpatient data showed a higher percentage of females with lyme disease visits. geographic trends did not match well between surveillance data and mhdo data which may be due to the hospital being used as proxy for the patient address. timeliness trends we re consistent between all sources, with the majority of lyme disease occurring in the summer months of june, july and august. the majority of outpatient visits had lyme disease listed as their primary diagnosis while the majority of inpatient visits had lyme disease as a secondary or lower diagnosis. conclusions: there were several limitations to this study including incomplete data, and the inability to differentiate between new and old lyme diagnoses. there is reasonably good similarity in the trends of these two systems helping validate the usefulness of maine’s lyme disease surveillance system. many of the discrepancies warrant further investigation, and may lead to future opportunities for education or improvement in lyme disease surveillance. correspondence: sara.robinson@maine.gov doi: 10.5210/ojphi.v5i3.4990 copyright ©2014 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health info rmatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi background lyme disease is the most commonly reported vectorborne illness in the united states, and 95% of cases are reported from thirteen states, of which maine is one [1]. lyme disease is caused by the borrelia burgdorferi spirochete bacteria and is transmitted through the bite of an infected ixodes scapularis or deer tick. the most common early symptom of lyme disease is the formation of a characteristic expanding rash called erythema migrans or em. other early symptoms include fever, headache, joint and muscle pains, and fatigue. in maine, lyme disease is the third most commonly reported infectious disease behind chlamydia and hepatitis c ii . cases of lyme disease have increased exponentially over the last decade following the expansion of the ixodes scapularis tick [2]. lyme disease was first detected in the southern counties within the state, but has spread up the coast and into western maine. lyme is now considered endemic in all sixteen maine counties. maine center for disease control and prevention’s infectious disease epidemiology program is responsible for monitoring disease incidence within the state. lyme disease is a reportable condition, and lyme disease surveillance in maine is a passive system. maine cdc receives reports of clinically diagnosed lyme disease (em rash), as well as positive laboratory results. each suspect case is entered into maine’s surveillance system which is a nedss base system (nbs). a case report form is sent to the provider to collect information on demographics, symptoms, and risk factors. returned case report forms are then classified by an epidemiologi st using the standard council of state and territorial epidemiologists case definition [3]. the updated information is entered into maine’s nbs. an em rash alone is confirmatory in maine, because lyme disease is endemic in all of our counties. the maine health data organization (mhdo) was created by legislature in 1996 to “collect clinical and financial health care information and to exercise responsible stewardship in making this information accessible to the public” [4]. mhdo collects information on inpatient and outpatient hospital encounters which are available annually. this reporting is required in maine rules and the definitions of who must submit data and what data must be submitted are clearly spelled out. because maine’s lyme disease surveillance system is a passive system it would be useful to compare the data acquired through surveillance to a secondary source in order to evaluate the completeness of the data and verify trends. specifically we are looking for similarity in trends of age groups, gender, geography, and timelines. reports of hospitalizations due to lyme disease are rare, but we have not reviewed hospitalization records to determine the validity of the rates. little is known about the individuals hospitalized for lyme disease in maine, including if lyme disease is the primary diagnosis, or a secondary diagnosis. methods surveillance data was extracted from maine’s nbs for the years 2008 – 2011. only confirmed and probable cases were included in data analysis. this data source includes patients who were seen by a provider for lyme disease and met the federal case definition. http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi mhdo inpatient and outpatient hospital encounters with a diagnosis of 08881 in any diagnosis field were extracted from the full dataset from 2008 – 2011. data were de-duplicated using hospital id, medical record number, date of service, and sequential visit number. data for inpatient visits and outpatient visits were analyzed separately. this data includes provider visits for lyme disease, but no case classification is applied. all data analysis and manipulation was performed using sas 9.3 statistical software. all geographic mapping and analysis was performed using arc gis arc info 10. rates were calculated using census data for each year, and are per 100,000 persons. data and analysis overall results from 2008 -2011 data was available for outpatient visits, inpatient visits, surveillance cases, and surveillance cases that were hospitalized. overall, outpatient visits decreased significantly in 2010 and 2011. inpatient visits, and surveillance cases that were hospitalized remained relatively stable during all four years. surveillance cases increased yearly with the exception of 2010 (table 1). table 1: number of visits for lyme disease and surveillance cases of lyme disease – maine, 2008-2011 mhdo data surveillance data outpatient visits inpatient visits cases hospitalizations 2008 3048 109 909 38 2009 3544 118 976 46 2010 1173 107 751 25 2011 1278 127 1012 51 age groups for the purpose of looking at trends by age group, outpatient visit data was used to compare to surveillance data. we assume that inpatient data is likely skewed based on other underlying conditions, so outpatient visit data would be more comparable to sur veillance data. the data was stratified into six standardized age groups (<5 years, 5 – 14 years, 15 24 years, 25 – 44 years, 45 – 64 years and over 65 years). counts were converted to rates and are displayed for both outpatient data and surveillance data in table 2. surveillance data consistently shows the highest rate to be in the 5 -14 year age group, with the second highest rate in the 45-64 year age group, and the third highest rates in the over 65 years age group. the age group with the lowest rate varies by year (figure 1). http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi table 2: rates per 100,000 persons of lyme disease by age group, surveillance and outpatient data – maine, 2008-2011 2008 2009 2010 2011 age groups surveillance outpt surveillance outpt surveillance outpt surveillance outpt <5 43.6 63.3 58.6 88.6 36.1 21.7 68 20.7 5 14 104 130.4 117.2 175.4 77.2 34.0 111 46.9 15 24 50 118.6 58.2 137.6 40.6 52.5 64.4 57.8 25 44 51.6 261.2 50.8 250.0 46.2 98.8 58 93.2 45 64 84 304.7 85.4 352.6 65.2 113.0 85.8 130.9 65+ 61 255.2 69.7 356.9 59.6 114.5 71.2 121.6 figure 1: rate per 100,000 persons by age group, surveillance data – maine, 2008-2011 the outpatient data shows the highest rates to be in the 45 – 64 years and over 65 years age groups. children less than 5 years old consistently have the lowest rate in the outpatient data (figure 2). http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi figure 2: rate per 100,000 persons by age group, mhdo outpatient data – maine, 2008-2011 absolute counts were used to look at hospitalization data because the denominator for hospitalizations was unknown. mhdo inpatient visits were used to due to higher numbers than the surveillance hospitalizations. the majority of inpatient visits for lyme disease occurred in adults 25 years and older. the age group with the highest count varied by year, but shifted from the 45 – 64 to the over 65 years age group over time (figure 3). figure 3: hospitalization by age group, mdho data – maine, 2008-2011 http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi gender surveillance data and inpatient data showed no significant gender differences for lyme disease. outpatient visits had a higher percentage of female visits than male visits; this was consistent for all four years (table 3). table 3: gender of lyme disease cases; mdho and surveillance data – maine 2008-2011 2008 2009 2010 2011 mhdo surv mhdo surv mhdo surv mhdo surv gende r inpt outp t case s inpt outp t case s inpt outp t case s inpt outp t case s f 53 1805 418 51 1977 439 50 691 353 55 744 433 m 56 1243 493 67 1567 531 57 482 398 72 534 579 % f 48. 6 59.2 45.9 43. 2 55.8 45.3 46. 7 58.9 47 43. 3 58.2 42.8 geography surveillance trends in maine show that lyme disease was first endemic in the southern counties of the state, and then moved up the mid-coast region. over half of the lyme disease cases have occurred in the southern two counties in the state (cumberland and york). however, these two counties are the most populated counties in the state, so to look at the true burden of disease we converted counts into rates. accounting for population, the southern two counties (cumberland and york), and the four mid-coast counties (knox, lincoln, sagadahoc, and waldo) had the highest rates of lyme disease (appendix 1). mhdo outpatient visit data rates varied by year. franklin county in western maine had consistently high rates, and the mid-coast area had relatively high rates. sagadahoc county had a rate of zero, but this is likely due to the fact that there is no hospital in sagadahoc county, not that there are no cases there (appendix 2). timelines ticks can be active any time the temperature is above 40 degrees fahrenheit, so cases of lyme disease are acquired year round in the state. however, the prevalence of ticks is much higher during the summer months, and therefore we expect to see the majority of the cases to be acquired during these months. surveillance data uses the onset date to classify the case into months. we used the date of the visit for the mhdo dataset to classify cases into months. the mhdo inpatient and outpatient data and the surveillance data all showed june, july, and august to be the months with the most lyme disease visits and cases. (figures 4, 5 and 6) http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi figure 4: inpatient visits for lyme disease by month – maine, 2008-2011 0 5 10 15 20 25 30 jan feb mar apr may jun jul aug sep oct nov dec # l y m e v is it s 2008 ip 2009 ip 2010 ip 2011 ip figure 5: outpatient visits for lyme disease by month – maine, 2008-2011 0 100 200 300 400 500 600 jan feb mar apr may jun jul aug sep oct nov dec # l y m e v is it s 2008 op 2009 op 2010 op 2011 op figure 6: surveillance cases of lyme disease by month – maine, 2008-2011 0 50 100 150 200 250 300 jan feb mar apr may jun jul aug sep oct nov dec # l y m e c a se s 2008 2009 2010 2011 http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi diagnosis codes the first ten diagnosis codes were available for all mhdo inpatient and outpatient visits. this data was analyzed to determine the percentage of visits with a lyme disease code within the first five diagnoses. the last five diagnoses were collapsed into an ”other diagnosis”category due to the small numbers. it is assumed that diagnosis 1 is the primary diagnosis; diagnosis 2 is the secondary diagnosis and so on. lyme disease was the primary diagnosis in only 27 -40% of inpatient visits (table 4). more than half of all outpatient visits had lyme disease as the primary diagnosis (table 4). table 4: percentage of inpatient and outpatient visits for lyme disease by diagnosis code – maine, 2008-2011 inpatien t diagnosis 1 diagnosis 2 diagnosis 3 diagnosis 4 diagnosis 5 other diagnoses 2008 33.0 31.2 17.4 5.5 4.6 8.3 2009 40.7 34.7 8.5 7.6 1.7 6.8 2010 27.1 36.4 17.8 7.5 3.7 7.5 2011 28.3 33.1 20.5 10.2 6.3 1.6 outpatient 2008 71.2 15.9 7.3 2.7 1.7 1.2 2009 67.9 17.4 8.8 3.5 1.3 1.1 2010 52.8 26.3 11.7 4.4 3.5 1.3 2011 52.1 22.6 11.4 6.0 4.9 3.0 discussion and conclusion lyme disease is a major public health concern in maine. the number of surveillance cases reported each year continues to rise, with no plateau in sight. because maine has a passive system for lyme disease surveillance, it was important to compare surveillance results with a secondary source in order to ascertain the effectiveness of our current surveillance system. there are several interesting findings through this comparison. this was our first attempt to use mhdo data to look for trends and the mhdo data is not directly comparable to surveillance case data for many reasons. first, individuals may be counted in the mhdo set more than once. each time the person sought care counted as a new visit, which may dramatically inflate the numbers as one patient may be seen multiple times and at multiple locations. the surveillance data is patient centric, and each individual can only be counted once within a year. it is also recognized that the surveillance case definition is more specific than a clinical diagnosis. in other words, not all clinical cases of lyme disease will be counted as cases using the surveillance definitions. however, it seems reasonable that although the scale is inflated for the mhdo data, the trends should still exist. the first concern identified in the data is the dramatic decrease in outpatient visits in 2010 and 2011. the surveillance case numbers continued to rise, but the http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi outpatient visits fell. this could be due to a change in how the data was collected, or in how the data was pulled for this analysis. this difference warrants further investigation. in looking at the age group trends, it was surprising to see that the 5-14 year old age group did not have the highest rates in the outpatient data as expected. this could be due to the fact that children may be more likely to see a pediatrician rather than going to a hospital related outpatient clinic, but warrants further investigation. adults over 45 years had high rates in both the surveillance data and the mhdo outpatient data which was expected. adults over 45 years also had the highest number of hospitalizations, but this is not surprising because as individuals age they tend to develop other co-morbidities or underlying conditions that may make them more prone to hospitalization in general. the gender analysis showed a much higher percentage of females with lyme disease related visits in the mhdo outpatient data than either the inpatient data or the surveillance case data. the literature shows that women tend to access health care more than men, so this may not be an unusual finding [5]. the geographic analysis was perhaps the most interesting finding of this comparison. the rates of lyme disease cases by county did not match the rates of lyme disease visits by county. the distribution of surveillance cases matches the distribution of the ixodes scapularis tick, and is well recognized as how the disease is moving through the state [6]. we expect the mhdo data to be skewed towards population centers because that is where the major hospitals are, and where there are more hospital related clinics. the data are also affected where there is no hospital (sagadahoc county with a consistent rate of 0). however cumberland county has a consistently lower rate than its surrounding counties which does not make sense. perhaps there is a difference in how people in different counties utilize the health care system. maybe some of the larger counties have more options for health care and so they are less likely to use a hospital system provider. it is unclear as to why the geographic trends do not match, but this is definit ely something to investigate further. the timeliness trends showed no surprises. the majority of visits and onset dates for lyme disease were in the summer months which are when the tick density is highest, but cases are seen year round. analysis of the diagnosis data provided some interesting information. the majority of outpatient visits had lyme as the primary diagnosis, which can be used to infer that lyme is the reason the patient went to the provider. however, only a small number of inpatient visits had lyme disease as the primary diagnosis. this suggests that lyme is either a secondary finding after hospitalization, or a contributing factor in most cases. we expect low hospitalization rates due to lyme disease itself, so this finding confirms that theory. it would be interesting to see what the common primary diagnoses are for patients for whom lyme is not the primary diagnosis. overall, this analysis showed that there are strengths and opportunities for maine’s current surveillance system. the majority of the trends investigated were similar in both systems which supports the usefulness of the surveillance system. however, the mhdo data has much higher numbers than the surveillance data. it is difficult to tell if this is due to duplication in the mhdo dataset, or missed cases in the surveillance data – it is probably a combination of both. we are http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi well aware that providers have low compliance in reporting em rash alone, and the mhdo data supports the idea that we might be missing clinically diagnosed ca ses. further investigation is needed to look at the differences identified through this analysis. limitations there are many limitations to this analysis. the mhdo data is not as clean as surveillance data, and may be misleading due to multiple visits by a single patient. the data set used for this analysis may be incomplete as suggested by the drop in numbers for 2010 and 2011. using the facility for the geographic analysis is not as accurate as using patient demographic data, but patient level data was unavailable for this analysis. another limitation is that the mhdo only contains data for hospital systems and not all outpatient providers. this skews the analysis to those who use emergency rooms and urgent cares as opposed to individuals who may use an independent health care provider. a major limitation is the use of icd -9 codes for analysis. there is only a single icd-9 code for lyme disease, and because of this we cannot tell if the patient is being newly diagnosed with lyme disease, or if the diagnosis is old. icd-10 coding will improve this, as it will have multiple coding options for lyme disease. future directions this analysis created some questions that should be investigated further. an investigation into why the outpatient lyme disease visits dropped so dramatically in 2010 and 2011 is warranted. the geographic analysis should be repeated with patient level demographics as opposed to facility locations to see if that improves the degree of matching between the two systems. further investigation into the primary diagnoses of inpatient lyme disease visits may reveal useful information. as hospital systems begin to change to icd-10 codes this presents an opportunity to use the maine health information exchange (hin) to identify cases that may be missed during surveillance. icd-10 has a code specifically for erythema migrans, which is confirmatory in maine. as hospitals begin to switch to icd-10 codes maine cdc can collaborate with maine hin to transmit cases with this diagnosis directly to our nbs. this will improve provider compliance with reporting and will make our surveillance system more robust. references: 1. centers for disease control and prevention. lyme disease. updated december 6, 2013. available at http://www.cdc.gov/lyme/stats/index.html. accessed 12/10/2013. 2. robbins a, mallis h. reportable infectious disease in maine: 2012 summary. available at http://www.maine.gov/dhhs/mecdc/infectious-disease/epi/publications/2012-annual-report.pdf. accessed 12/10/2013. 3. centers for disease control and prevention. national notifiable diseases surveillance system (nndss): lyme. updated november 14, 2013. available at http://wwwn.cdc.gov/nndss/script/conditionsummary.aspx?condid=100. accessed 12/10/2013. 4. maine health data organization. available at https://mhdo.maine.gov/index.aspx. accessed 11/10/2013. 5. bertakis kd, azari r, helms lj, callahan ej, robbins ja. 2000. gender differences in the utilization of health care services. j fam pract. 49(2), 147-52. pubmed http://ojphi.org/ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=10718692&dopt=abstract lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi 6. maine medical center research institute. lyme and other vector-borne disease information: map of deer tick distribution in maine updated 2011. available at http://www.mmcri.org/home/websubcontent.php?list=websubcontentlive&id=197&catid=4&subcatid=19. accessed 12/10/2013. http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi appendix 1: surveillance lyme disease rates by county, maine 2008-2011 http://ojphi.org/ lyme disease in maine: a comparison of nedss surveillance data and maine online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e231, 2014 ojphi appendix 2: mhdo outpatient lyme disease rates by county, maine 2008-2011 http://ojphi.org/ layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts category-specific comparison of univariate alerting methods for biosurveillance decision support yevgeniy elbert*, vivian hung and howard burkom jhuapl, laurel, md, usa objective for a multi-source decision support application, we sought to match univariate alerting algorithms to surveillance data types to optimize detection performance. introduction temporal alerting algorithms commonly used in syndromic surveillance systems are often adjusted for data features such as cyclic behavior but are subject to overfitting or misspecification errors when applied indiscriminately. in a project for the armed forces health surveillance center to enable multivariate decision support, we obtained 4.5 years of outpatient, prescription and laboratory test records from all us military treatment facilities. a proof-of-concept project phase produced 16 events with multiple evidence corroboration for comparison of alerting algorithms for detection performance. we used the representative streams from each data source to compare sensitivity of 6 algorithms to injected spikes, and we used all data streams from 16 known events to compare them for detection timeliness. methods the six methods compared were: 1) holt-winters generalized exponential smoothing method (1) 2) automated choice between daily methods, regression and an exponential weighted moving average (2) 3) adaptive daily shewhart-type chart 4) adaptive one-sided daily cusum 5) ewma applied to 7-day means with a trend correction; and 6) 7-day temporal scan statistic sensitivity testing: we conducted comparative sensitivity testing for categories of time series with similar scales and seasonal behavior. we added multiples of the standard deviation of each time series as single-day injects in separate algorithm runs. for each candidate method, we then used as a sensitivity measure the proportion of these runs for which the output of each algorithm was below alerting thresholds estimated empirically for each algorithm using simulated data streams. we identified the algorithm(s) whose sensitivity was most consistently high for each data category. for each syndromic query applied to each data source (outpatient, lab test orders, and prescriptions), 502 authentic time series were derived, one for each reporting treatment facility. data categories were selected in order to group time series with similar expected algorithm performance: 1) median > 10 2) 0 < median ! 10 3) median = 0 4) lag 7 autocorrelation coefficient " 0.2 5) lag 7 autocorrelation coefficient < 0.2 timeliness testing: for the timeliness testing, we avoided artificiality of simulated signals by measuring alerting detection delays in the 16 corroborated outbreaks. the multiple time series from these events gave a total of 141 time series with outbreak intervals for timeliness testing. the following measures were computed to quantify timeliness of detection: 1. median detection delay – median number of days to detect the outbreak. 2. penalized mean detection delay –mean number of days to detect the outbreak with outbreak misses penalized as 1 day plus the maximum detection time. results based on the injection results, the holt-winters algorithm was most sensitive among time series with positive medians. the adaptive cusum and the shewhart methods were most sensitive for data streams with median zero. table 1 provides timeliness results using the 141 outbreak-associated streams on sparse (median=0) and nonsparse data categories. [insert table #1 here] the gray shading in the table 1 indicates methods with shortest detection delays for sparse and non-sparse data streams. the holt-winters method was again superior for non-sparse data. for data with median=0, the adaptive cusum was superior for a daily false alarm probability of 0.01, but the shewhart method was timelier for more liberal thresholds. conclusions both kinds of detection performance analysis showed the method based on holt-winters exponential smoothing superior on non-sparse time series with day-of-week effects. the adaptive cusum and shewhart methods proved optimal on sparse data and data without weekly patterns. keywords biosurveillance; timeliness; detection; alerting methods; sensitivity references 1. elbert y, burkom h, shmueli g, development and evaluation of a dataadaptive alerting algorithm for univariate temporal biosurveillance data stat. med. 2009; 28:3226-3248 2. burkom h, elbert y, thompson m, et al, development, adaptation, and assessment of alerting algorithms for biosurveillance jhuapl technical digest, volume 24, number 4 (2003) *yevgeniy elbert e-mail: yevgeniy.elbert@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e89, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts advancing surveillance of chronic and noncommunicable disease—a path forward elissa r. weitzman1, 3 and nadia waheed*2, 4 1harvard medical school, boston, ma, usa; 2tufts university school of medicine, boston, ma, usa; 3boston children’s hospital, boston, ma, usa; 4new england eye center, boston, ma, usa objective to characterize current and future approaches to surveillance of chronic and non-communicable diseases and establish the agenda for both methodological and condition-specific progress. introduction major global stakeholder groups including the united nations, world health organization and institute of medicine seek to raise awareness of the threat to global health and security of chronic and non-communicable diseases. these conditions comprise 50-85% of the global annual morbidity burden and constitute a major drain on national economies. to move from awareness of this problem to action and amelioration of issues, we need effective means for monitoring and intervening with populations using approaches that span primary, secondary and tertiary prevention. methods this session will begin with a discussion of key concepts and terms and their implications for defining target problems, populations and surveillance strategies. we will also begin by reviewing the epidemiologic and economic arguments for advancing surveillance in this area. the discussion will center on a critical assessment of issues related to surveillance of chronic and non-communicable diseases: how do approaches differ from established and evolving approaches to surveillance of infectious disease? are there opportunities for synergy with current surveillance efforts and assets? where are new methods needed? how might surveillance approaches be advanced in different regions (e.g., developing and industrialized settings)? might new approaches predicated on “citizen science” and engaged patient and public health cohorts provide platforms for advancing surveillance of chronic and non-communicable diseases and what is required to ensure their success? results points of discussion: 1) participants are encouraged to come prepared to share their experiences engaging patient and public health cohorts in this area, including sharing experiences engaging cohorts using online social networks, participatory research and surveys. 2) brainstorm ideas for development of a workshop in non-communicable disease surveillance. sample questions: 1) what are the issues related to surveillance in the context of resource rich and poor contexts? 2) what are the special needs for establishing cost-effective and sustainable methods for longitudinal tracking? 3) how can technological advances and engaged patient and public health cohorts be used in the advancement of surveillance? what are methods to maximize engagement in both the developed and developing world? conclusions non-communicable diseases are a major and growing morbidity and mortality burden globally. this round table discussion will focus on the importance of non-communicable disease surveillance, attempt to elicit participant’s experiences in the surveillance of these conditions, and outline special needs for establishing cost-effective and sustainable methods for longitudinal tracking of non-communicable diseases. keywords surveillance; non communicable diseases; chronic diseases acknowledgments dr weitzman’s work is supported by po1hk000088-01 from the centers for disease control and prevention (cdc), national library of medicine grant 5r01lm007677 and 1u54rr025224-01 from ncrr/nih. *nadia waheed e-mail: nwaheed@tuftsmedicalcenter.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e197, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts case based surveillance for measles in lagos, south western nigeria, september 2011 olawunmi o. adeoye*1, abimbola aman-oloniyo2, patrick nguku1, abiola oduneye2 and modupe dawodu2 1nigeria field epidemiology and laboratory training programme, abuja, nigeria; 2lagos state ministry of health, alausa, ikeja, lagos, nigeria objective the objective of this study was to describe the performance of the measles surveillance in lagos, characterize the epidemiologic pattern of measles infection and determine the measles vaccine efficacy. introduction measles is a vaccine preventable disease that has been successfully eliminated in some parts of the world. it causes high morbidity and mortality with the potential of large outbreaks. about a third of reported measles cases involve one or more complications including diarrhea, pneumonia, otitis media, blindness, post infections encephalitis and subacute sclerosing panencephalitis. it is however, one of the leading causes of childhood morbidity and mortality in nigeria despite availability of safe and effective vaccines methods we obtained the measles surveillance data for all the 20 local governments areas (lgas) in lagos and reviewed all the measles case based investigation forms between the period 1st january to 31st december 2010.the who recommended surveillance standards for measles was used. data was analyzed using epi info version 3.5.3. results of the 615 suspected measles cases, 63(10.2%) were laboratory confirmed (measles igm+) and 3(0.5%) clinically confirmed. cases investigated within 48 hours was 222 (36%) (target ! 80%), 510 (83%) had adequate blood sample collected (target ! 80%) and 595 (97%) of sample results were received from the lab within 7 days (target ! 80%). the surveillance system sensitivity was 6.5/100,000 (target >2/100,000) with a predictive value positive of 10.73%. the overall attack rate was 0.73/100,000 population with 1 mortality (case fatality rate 1.5%). the under 1 year attack rate (8.33/100,000) was higher than the 14 years attack rate (3.48/100,000) (p= 0.01). those vaccinated with at least 1 dose of measles vaccine had a 3 times lower risk of measles infection than the unvaccinated. the proportion of unvaccinated cases was 36%. the measles vaccine efficacy was 60%. conclusions the quality of surveillance need to be strengthened by improving the time lapse between notification and investigation of suspected cases. measles is still a significant cause of morbidity particularly among the under 1 year age group.the proportion of unvaccinated cases is also high, suggesting a low vaccine coverage among susceptibles. prompt investigation of cases, good vaccine coverage and high vaccine efficacy are all vital in eliminating measles from nigeria. morbidity and mortality rates no of reported measles cases in lagos, south western nigeria by lga with onset date from 1st january 31st december 2010 legend keywords surveillance; measles; case based; lagos acknowledgments lagos state ministry of health, alausa, ikeja, lagos. central public health laboratory, yaba, lagos. world health organisation, lagos office, ikoyi, lagos. references kohlhagen jk et al. 2011. meeting measles elimination indicators: surveillance performance in a regional area of australia. western pacific surveillance and response journal,2011,2(3). who.2001. modules on best practisesfor measles surveillance. available at www.who.int/vaccines-document. (accessed september 2011). who.2003.recommended standards for surveillance of selected vaccine preventable diseases.available at www.who.int/vaccines-document. (accessed september 2011). *olawunmi o. adeoye e-mail: wunmiolat@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e151, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts risk of cardiovascular morbidity and mortality in relation to temperature robert mathes*, kazuhiko ito and thomas matte new york city department of health and mental hygiene, queens, ny, usa objective to examine the effects of temperature on cardiovascular-related (cvd) morbidity and mortality among new york city (nyc) residents. introduction extreme temperatures are consistently shown to have an effect on cvd-related mortality [1, 2]. a large multi-city study of mortality demonstrated a cold-day and hot-day weather effect on cvd-related deaths, with the larger impact occurring on the coldest days [3]. in contrast, the association between weather and cvd-related morbidity is less clear [4, 5]. the purpose of this study is to characterize the effect of temperature on cvd-related emergency department (ed) visits, hospitalizations, and mortality on a large, heterogeneous population. additionally, we conducted a sensitivity analysis to determine the impact of air pollutants, specifically fine particulates (pm2.5) and ozone (o3), along with temperature, on cvd outcomes. methods we analyzed daily weather conditions, ed visits classified as cvd-related based on chief complaint text, hospitalizations, and natural cause deaths that occurred in nyc between 2002 and 2006. ed visits were obtained from data reported daily to the city health department for syndromic surveillance. inpatient admissions were obtained from the statewide planning and research cooperative system, a data reporting system developed by new york state. mortality data were obtained from the nyc office of vital statistics. data for pm2.5 and o3 were obtained from all available air quality monitors within the five boroughs of nyc. to estimate risk of cvd morbidity and mortality, we used generalized linear models using a poisson distribution to calculate relative risks (rr) and 95% confidence intervals (ci). a non-linear distributed lag was used to model mean temperature in order to allow for its effect on the same day and on subsequent days. models were fit separately for cold season (october through march) and warm season (april through september) given season may modify the effect on cvd outcomes. for our sensitivity analysis, we included pm2.5 and o3 in our model. results during the cold season, cvd-related ed visits and hospitalizations increased, while mortality decreased, with increasing mean temperature on the same day and lagged days. extremely cold temperature was associated with a small increase of same day in-hospital mortality though generally cold temperatures did not appear to be associated with higher mortality. the opposite was observed in the warm season as ed visits and hospitalizations decreased, and mortality increased, with increasing mean temperature on the same day and on lagged days. our sensitivity analysis, in which we controlled for pm2.5 and o3, demonstrated little effect of these air pollutants on the relationship between temperature and cvd outcomes. conclusions our results suggest a decline in risk of a cvd-related ed visit and hospitalization during extreme temperatures on the same day and on recent day lags for both cold and warm seasons. in contrast, our findings for mortality indicate an increase in risk of cvd-related deaths during hot temperatures. no mortality effect was observed during cold temperatures. the effects of extreme temperatures on cvd-related morbidity may be explained by behavioral patterns, as people are more likely to stay indoors on the coldest and hottest days. keywords morbidity; mortality; cardiovascular; temperature acknowledgments this research was funded by the environmental protection agency, star grant r833623010, and in conjunction with the alfred p. sloan foundation, grant 2010-12-14. we thank the members of the new york city department of health and mental hygiene syndromic surveillance unit. references 1. basu, r. and b.d. ostro, a multicounty analysis identifying the populations vulnerable to mortality associated with high ambient temperature in california. am j epidemiol, 2008. 168(6): p. 632-7. 2. braga, a.l., a. zanobetti, and j. schwartz, the effect of weather on respiratory and cardiovascular deaths in 12 u.s. cities. environ health perspect, 2002. 110(9): p. 859-63. 3. medina-ramon, m. and j. schwartz, temperature, temperature extremes, and mortality: a study of acclimatisation and effect modification in 50 us cities. occup environ med, 2007. 64(12): p. 827-33. 4. josseran, l., et al., syndromic surveillance and heat wave morbidity: a pilot study based on emergency departments in france. bmc med inform decis mak, 2009. 9: p. 14. 5. knowlton, k., et al., the 2006 california heat wave: impacts on hospitalizations and emergency department visits. environ health perspect, 2009. 117(1): p. 61-7. *robert mathes e-mail: rmathes@health.nyc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e144, 2013 covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina gregory d. kearney, drph1*, katherine jones, phd1, yoo min park, phd2, rob howard, ms2, ray hylock, phd3, bennett wall, mba4, maria clay, phd5, peter schmidt, phd6, john silvernail, md, mph7 1department of public health, brody school of medicine at east carolina university, 2department of geography, planning and environment, east carolina university, 3department of health services & information management, east carolina university, 4vidant health, integrated care, 5department of bioethics & interdisciplinary studies, brody school of medicine at east carolina university, 6department of neurology, grossman school of medicine, new york university, 7pitt county health department abstract background: the initial limited supply of covid-19 vaccine in the u.s. presented significant allocation, distribution, and delivery challenges. information that can assist health officials, hospital administrators and other decision makers with readily identifying who and where to target vaccine resources and efforts can improve public health response. objective: the objective of this project was to develop a publicly available geographical information system (gis) web mapping tool that would assist north carolina health officials readily identify highrisk, high priority population groups and facilities in the immunization decision making process. methods: publicly available data were used to identify 14 key health and socio-demographic variables and 5 differing themes (social and economic status; minority status and language; housing situation; at risk population; and health status). vaccine priority population index (vpi) scores were created by calculating a percentile rank for each variable over each n.c. census tract. all census tracts (n = 2,195) values were ranked from lowest to highest (0.0 to 1.0) with a non-zero population and mapped using arcgis. results: the vpi tool was made publicly available (https://enchealth.org/) during the pandemic to readily assist with identifying high risk population priority areas in n.c. for the planning, distribution, and delivery of covid-19 vaccine. discussion: while health officials may have benefitted by using the vpi tool during the pandemic, a more formal evaluation process is needed to fully assess its usefulness, functionality, and limitations. conclusion: when considering covid-19 immunization efforts, the vpi tool can serve as an added component in the decision-making process. keywords: informatics, covid-19, public health, spatial, vaccine abbreviations: vaccine priority index (vpi) correspondence: kearneyg@ecu.edu* mailto:kearneyg@ecu.edu* covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi introduction on february 9, 2021, the centers for disease control and prevention reported nearly 27 million cases and 464,000 deaths related to covid-19 in the u.s.[1] as vaccine supply became increasingly more available, the initial deployment of phased vaccine roll-out plans across the u.s. brought about significant challenges. according to one report, the vaccine shortage saw many states diverging from cdc guidance, operating on different timelines and prioritizing different groups, and were increasingly dependent on where a person lived.[2] other news reports described the slow roll-out and allocation of covid-19 vaccine as chaotic and marred by logistical inconsistencies, with varying strategies and disproportionate socioeconomic power structures.[35] without question, the covid-19 pandemic crisis created new and unprecedented challenges. amid the rush to mass immunize the public with limited vaccine supplies, critical strategic planning and evaluation efforts were needed a priori to ensure efficient and equitable distribution of vaccine to high-risk, priority populations. for example, older adults living in isolated rural areas struggled with low vaccine allocation and transportation barriers. [6] the ability for health officials to identify high risk populations and facilities in advance, could assist in planning efforts, including improving supply chain delivery, providing accurate estimates of doses to safeguard communities. this paper describes the north carolina, vaccine priority index (vpi) mapping tool developed by researchers and partners at east carolina university and vidant medical center. this product was developed during the pandemic as an attempt to assist busy health officials and hospitals in the vaccine decision making process. prioritizing vaccine distribution in september 2020, the national academies of sciences and medicine released the preliminary framework for equitable allocation of covid-19 vaccine. [7] as described in the report, the committee recognized that when available, the allocation of initial supply of covid-19 vaccine would be tightly constrained. furthermore, setting priorities for the equitable allocation of vaccine were admittingly challenging given the differing risk and exposure factors by varying population and occupational groups. it was further noted that assigning priority at an individual level posed considerable constraints and were impractical for delivering vaccine. [7] doi: 10.5210/ojphi.v13i3.11617 copyright ©2021 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in t he copy and the copy is used for educational, not-for-profit purposes. covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi figure 1. national academies of science and medicine phased approach to vaccine access. [7] considering the many factors associated with the allocation of vaccine, the committee operationalized risk criteria by characterizing populations and occupational groups based largely on risk and ability of vaccine to mitigate those risks. using the best available evidence, the committee recommended a four “phased,” successive approach for covid-19 vaccine allocation (figure 1). in phase 1 (highest priority), high risk workers in healthcare facilities, first responders, people with significant comorbid conditions and older adults in congregate or overcrowded conditions/settings would receive the initial doses of vaccine. as noted, “equity” was included as a “cross-cutting consideration” as part of the phased allocation process for vaccine access. to assist with identifying geographical areas for prioritization, the centers for disease control and prevention (cdc), social vulnerability index (svi) was suggested. in brief, the svi is a standardized, data driven system, vulnerability mapping application tool developed primarily to assist emergency disaster management personnel with identifying geographic areas of economic loss, providing social services and public assistance following natural disasters. [8] covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi approach to vulnerability mapping while the decision to allocate vaccine based solely on population density is one approach for helping communities reach herd immunity, it is flawed by taking into account inherent differences in risks and vulnerability experienced by different individuals and population groups. [9] by identifying where high-risk, vulnerable populations are located, health officials, hospital administrators and other decision-makers can better plan where to target vaccine delivery and intervention strategies. the social, economic, and health geographics of north carolina varies considerably across the state; regions, counties, and census tracts differ in population density, urban and rural status, income, race, ethnicity, and health status. likewise, covid-19 morbidity and mortality rates differ widely. some geographic regions have more vulnerable populations including the medically fragile and elderly. other high-risk groups including frontline health workers, first responders, and workers in occupations deemed “essential” tend to congregate near facilities where they work. while some individuals have resources to help them cope with the virus, others may not. for example, low-wage workers often lack health insurance, do not have transportation to get tested, or go to work when they are ill because they cannot afford to miss work. such challenges pose considerable exposure risk to covid-19 for individuals and their co-workers, families, and others in their communities. these low socio-economic factors are key drivers of a person's susceptibility to contracting the virus and managing their sickness once they become ill. given these limitations, a model of prioritization, allocation, and distribution model for covid-19, based solely on population density has inherent limitations in reducing the spread. the aforementioned cdc, svi method is one approach to consider when prioritizing population vulnerability primarily attributed to the community where they reside.[8] the svi was designed to standardize a measure of socio-economic status and vulnerabilities at the geographical census tract level. the index has been used extensively in the application for identifying population vulnerability with natural disasters. [10-13] while the svi continues to prove useful for mapping vulnerability, it was not designed with considerations of risk factors associated with an infectious agent. as covid-19 spreads, health decision-makers need to have the ability to quickly identify geographic areas that include high-risk facilities and populations so that resources can be allocated and deployed to protect public. a vaccine priority index for n.c. on october 16, 2020, the state of north carolina released its covid-19 vaccination plan and prioritized critical population groups that would receive the vaccine.[14] using guidance from the nam recommendations, it identified a “phased approach” that included high risk health workers, staff in long term care, people over 65 and staff of congregate living settings (i.e., migrant farm camps, jails, prisons, homeless shelters, and anyone with two or more chronic conditions identified by cdc to be high risk for covid-19 complications). with the covid-19 pandemic in full swing, researchers from east carolina university and vidant medical center worked rapidly to create a website and develop an online, publicly available geospatial web mapping tool. our goal was to assist health officials, hospital administrators and other decision makers identify and target priority populations and high-risk facilities. phases 1a and covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi phase 1b of the n.c., vaccine prioritization index (vpi) is similar to the nam priority phased, framework. for this initial approach we focused our efforts on phases 1a and 1b. the purpose of this project was to develop a publicly available, online mapping tool that could assist decision makers quickly identify geographical areas of “high-risk, high priority” populations in phases 1a and 1b in the vaccination roll out plan in n.c. in pandemic situations where the need to identify locations and population characteristics are critical for mass vaccinations, this type of applied spatial method offers critical insight for planning, distribution, and delivery of targeted mitigation strategies. methods data, themes and variables the vaccine priority index is composed of 14 variables that describe risk and vulnerability relative to the covid-19 virus; the 14 variables are grouped into 5 themes (table 1). the themes are, 1) socioeconomic status, 2) minority status and language, 3) at-risk populations, 4) housing, and 5) health status. the variables within each of the themes were selected based on a combination of factors including population risk and vulnerability relative to the covid-19 virus, other vulnerability mapping tools, and a review of the literature. this project was reviewed and approved by east carolina university, institutional review board (umcirb# 20-001299). the vpi is modeled on the social vulnerability index. the vpi borrows some variables from the svi, but also adjusts for incorporated risk and vulnerability data pertinent to the covid-19 pandemic. the vpi also uses a similar ranking methodology to the svi to assign sub-index values to each census tract based on individual variables. sub-index values are then combined to create “themes” and the themes are combined to create an overall priority index. the data for four of the themes and eleven of the variables were derived from u.s. census data (american community survey 5-year data, 2014-2018). data for the remaining theme (health status) and three variables were obtained from the cdc, diabetes atlas and the center for medicare and medicaid services chronic conditions data warehouse. [15,16] covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi table 1. themes and associated variables for constructing the vaccine priority index themes socioeconomic status minority status & language special-at-risk population housing health status selected variables % below poverty % unemployed average per capita income % no high school diploma % minority % that speak english “less than well” % age 65 or older % of population who list occupation in high-risk group % of households crowded % of people who live in group quarters % of housing that is multi-unit % of adults who have diabetes % of adults who are obese % of medicare beneficiaries age 65 or older who have 2 or more chronic health conditions rationale for themes and variables theme 1, social and economic status. theme 1 combines percent below poverty, percent unemployed, percent without a high school diploma, and average per capita income in a census tract to create a theme to assess socio-economic status. it has been well established that individuals with fewer economic resources are less resilient when responding to disasters, and it is intuitive that this would also be true in a pandemic. this theme contains the same variables as the svi and is calculated in a similar fashion, except the census tracts are ranked only for the state of north carolina instead of the entire u.s. theme 2, minority status and language. theme 2 combines percent of the tract that is minority (non-white, or hispanic) and the percent that speak english “less than well.” in general, minority populations are at high risk of infectious diseases, particularly when living in multi-generational households and spatially concentrated in neighborhoods. [17,18] immigrants for whom english is not their native language are also disadvantaged when considering access to health care, testing, and vaccines. [19,20,21] this theme contains the same variables as the svi and is calculated similarly, but only includes north carolina and not the entire u.s. census tracts. theme 3: special-at-risk populations (also are those prioritized in phase 1). theme 3 combines the percent of the population that is age 65 and over and the percent of the population whose occupations are healthcare or first responder. increased age is a risk factor for becoming ill from covid19, and, for those who do become ill, for getting seriously ill or dying. covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi therefore, census tracts with a higher percent of individuals over age 65 are ranked higher priority for vaccine prioritization. certain occupations (e.g., healthcare) are also at higher risk for contracting covid-19 because of close contact with covid-positive individuals or because the worker is in an occupation where social distancing may not be possible (e.g., first responders). using census data, we calculated a percent of the total population in each census tract for occupational groups corresponding with healthcare workers and first responders. for healthcare workers, we combined healthcare practitioners, healthcare technical occupations, and healthcare support occupations. healthcare practitioners included physicians of all specialties, physician assistants, nurses, and dentists. healthcare technical occupations includes licensed practical nurses, emts, and health equipment technicians, including respiratory technicians. healthcare support occupations includes home health aides, nursing assistants, and cleaners and orderlies in a health care setting. the protective service occupation category was used for first responders and includes law enforcement, firefighters, and correctional service workers. the numbers for each of these groups were summed to create a total number of frontline workers for each census tract, and then the percent of the population was calculated. a census tract with a higher percent is deemed to be at a higher risk, and thus requires a higher priority for the vaccine. theme 4: housing. as a highly contagious virus, covid-19 transmission can occur in social settings, such as in congregate living, close work environments, and/or social occasions such as church services, weddings, funerals, restaurants, and bars. the home is an important transmission environment and one where many people are not able to socially distance from one another. the housing theme combines three census variables that describes features of the home and living situation that may increase risk for covid-19, primarily due to the closeness of the setting, proximity to others, and the inability of individuals to socially-distance. the first variable in the housing theme is multi-unit housing. this variable assesses settings such as apartment buildings, where people are sharing hallways, elevators, and mail stations. the variable measures the percent of housing units in a census tract that are part of a structure that contains 10 or more units. the second variable in the housing theme is crowded housing. housing units (rental or owner occupied, house or apartment) with more than 1 person per room are considered crowded. the variable assesses the number of housing units in a census tract that are crowded, as a percent of all housing units in the census tract. note, this measures persons per all rooms in the housing unit, not bedrooms. the third variable for the housing theme is the percent of individuals in the census tract who live in group quarters (institutional settings) such as, nursing homes, assisted living, college dorms, psychiatric hospitals or other long-term healthcare institutional settings, and correctional facilities. such congregate living arrangements have emerged as one of the riskiest settings for the spread of covid-19, and numerous outbreaks have been tied to these settings. the group quarters variable measures the number of persons in the census tract that live in such a setting, as a percent of all people in the tract. where the percent is higher, there is a higher level of vulnerability. covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi theme 5: health status. it is widely recognized that individuals with certain underlying health conditions are at significantly higher risk of severe covid-19 illness, or death. while the exact reasons and extent of this are not fully understood, the course of the pandemic thus far has demonstrated that individuals with diabetes, heart disease, kidney disease, copd, obesity, and immune compromised individuals are all at risk for more severe illness and death if they contract covid19. individuals with 2 or more of these or other serious health conditions are at an especially elevated risk. the vpi health status theme combines county-level data on the prevalence of diabetes, obesity, and chronic illness. we use county-level data because census tract level health status data is not readily available; the county value is assigned to each census tract within the county. three variables are combined for this theme. the first two variables for health status are the percent of adults in the county with diabetes and the percent who are obese. this data was obtained from the cdc, online diabetes atlas, which is a subset of the cdc, behavioral risk factor surveillance system (brfss).[15,22] the brfss is an annual health telephone survey conducted by states but standardized at the national level. these two health conditions (diabetes and obesity) are both important co-morbidity risk factors for covid-19, and this data provides a uniform, reliable estimate for health status at the county level. the third variable in the health status theme is the percent of medicare beneficiaries in the county over age 65 who have two or more chronic health conditions. the data was obtained from the center for medicare and medicaid services chronic conditions data warehouse [16] and defines an individual as having a chronic condition if persons had a claim for a service or treatment related to that condition within the previous year. it was selected to be included as a measure of population health as it provides a good, general estimate for health status at the county level. good quality health status data is scarce at the county level, so this data set was chosen for its availability, reliability, and consistency. vp index method to construct the vp index score for phase 1, source data from table 1 were compiled and scores were calculated by ranking all census tracts in north carolina with a non-zero population (n=2193) from low to high based on the individual variable. a census tract with a low percent in poverty is presumed to have lower vulnerability (and lower vaccine priority), while a tract with a high percent in poverty has a higher vulnerability (and a higher vaccine priority). one exception was income, which was inversely ranked high to low, since tracts with a higher income are presumed to have lower vulnerability, and lower income is presumed to have higher vulnerability. once ordered by low to high, each census tract was assigned a rank. the rank number was then used to create an index value. the index value is the rank number divided by the total number of tracts for that variable. the vpi was calculated using the formula, vaccine priority index = (rank -1)/ n-1 covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi census tracts with no population, or a zero value for the variable being ranked (no individuals in poverty live in that tract, for instance) were not assigned a rank, and received a zero value for that index. to calculate themes, indices for individual variables were summed together, and then the summed values re-ordered, low to high. a new rank was assigned for the summed value, and a new, combined index value calculated, using the same method. to calculate the overall vp index, the 5 theme indices were summed and re-ranked, and their rank number used to calculate the final index. the vp index ranges from 0 to 1. lower values indicate lower vulnerability, and lower priority for the vaccine, while higher values indicate higher vulnerability, and higher priority for the vaccine. application features word-press was used as the operating platform to build a host website to display the vpi (https://enchealth.org/). the website included covid-19 related dashboard visualizations and arcgis online (esri) mapping tool (figure 2). users that access the vpi through the website can navigate the mapping visualizations and view the numeric index values and estimated number and percent of high priority vaccine groups identified in phase 1a and phase 1b counties and census tracts. as shown in figure 3, a mouse-over a geographic area over the map will display a pop-up menu that provides an estimated count of high priority individuals in each county and census tract. the user can also turn the map layers “on or off” on the right-hand panel to display the vpi or the cdc’s social vulnerability index (svi). by zooming in, key point locations, such as nursing homes, pharmacies, or health clinics are displayed. using the filter panel on the left-hand side of the map, the vaccine priority index category filter and pick the “high” category. the map filters to show only those census tracts in the highest priority group. displays of the svi and vpi are both available at state, county, and census tract levels. the filters can also be used to filter geographic areas based on vpi categories or by the number of priority phases 1a and 1b groups including percent of healthcare workers, first responders, residents in nursing homes, assisted living facilities, and individuals with chronic health conditions. other features including map layers (e.g., imagery, streets, community maps), and individual facilities including the locations of health departments, hospitals nursing homes, meat processing facilities, correctional institutions and pharmacies) with address and information related to each facility are also viewable. https://enchealth.org/ covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi figure 2. eastern north carolina (enc health) vaccine priority index (https://enchealth.org/) covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi figure 3. vaccine priority index mapping tool (https://enchealth.org/) discussion the vpi was created in rapid response to the covid-19 pandemic and the need to provide health officials decision makers with added information for quickly identifying high risk populations and facilities for vaccine delivery. the advantages and challenges of the vpi are listed below. • efficient the vpi translates priority groups (e.g., nam recommended phase 1a and phase 1b priority groups) into a ranked index value to quickly determine where vulnerable groups are located. • rapid visualization key point locations of high-risk, key facilities including hospitals, nursing and assisted living homes, meat packing facilities, fqhc’s, pharmacies, correctional institutions and health departments can readily be found. additional base map layer features including roads and other imagery can be added to maps. as new location centers emerge (e.g., large vaccination sites or drive through sites) can easily be incorporated into the model. covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi • vaccine delivery while the data is derived from the us census and other publicly derived, national datasets, it is only a metric or a guide to assist with the vaccine delivery and distribution process. strengths and limitations the timing of the release of the vpi tool to n.c. health departments was critically important to it’s success and came at a time when vaccine plans for nc were initially being rolled out. our efforts to promote the tool’s usefulness and abilities to health officials and hospital administrators gained positive attention. however, given the overwhelming duties and responsibilities of healthcare workers and providers to the pandemic, our ability to gain feedback was somewhat limited. nevertheless, future plans include distributing formal surveys to health departments and others to gain additional insight so that modifications can be made accordingly. also, at the onset of this project, our vpi tool was unique, and there were few other mapping tools available. however, as time progressed, an increase in commercial and non-commercial mapping tools have become publicly available. many of the newer products display features with varying features, and capable of conducting advanced statistical analysis. nevertheless, the vpi remains unique to n.c. the data for the vpi were derived primarily from the u.s. census and health surveys. while we used the most current data sets for this project, changing population composition and people not necessarily living where they work, or play presents inherent limitations. [8] recommendations and conclusions covid-19 remains a highly communicable, infectious agent that threatens the health and safety of society. at the time of this writing, mass vaccination campaigns have occurred throughout the u.s. as covid-19 case and death rates show an overall downward trend, new variant strains continue to emerge, questioning the return to normal operations. other challenges such as hesitancy, access to care, conspiracy theories and other reasons contribute to an average of only 59.4% of adult americans having been fully vaccinated. [23] despite these challenges, public health and healthcare workers continue to remain vigilant in its prevention, intervention, and treatment efforts. the vpi tool can be considered a viable option for assisting decision makers with identifying high risk populations and areas to target to protect north carolina communities. acknowledgements thanks to support from people that assisted with the development of this project including the dartmouth atlas project, esri, dr. keith keene and cheryl walters denny at east carolina university. financial disclosure funding for this project was provided by north carolina house bill 1043, 2020, covid-19 recovery act. competing interests the authors have no competing interests. covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi references 1. covid data tracker. centers for disease control and prevention website. accessed february 10, https://covid.cdc.gov/covid-data-tracker/#datatracker-home 2. mukherjee s. states are “diverging from cdc guidance,” resulting in unequal vaccine rollout, experts say. fortune. february 17, 2021. accessed february 18, 2021. https://fortune.com/2021/02/17/covid-vaccine-cdc-guidelines-us-states-unequal-rolloutcoronavirus-vaccines-pfizer-biontech-moderna/ 3. appleby j. the state of vaccine supply: “opaque.’ unpredictable. “hard to pin down.” kaiser health news. february 5, 2021. accessed february 18, 2021. https://khn.org/news/article/thestate-of-vaccine-supply-opaque-unpredictable-hard-to-pin-down/ 4. johnson a. lack of health services and transportation impede access to vaccine in communities of color. washington post. feb. 13, 2021. accessed february 17, 2020. https://www.washingtonpost.com/health/2021/02/13/covid-racial-ethnic-disparities/ 5. khidir h, molina m. opinion: moral tragedy looms in early chaos of u.s. covid-19 vaccine distribution. national public radio. january 16, 2021. https://www.npr.org/sections/health-shots/2021/01/16/957236269/opinion-moral-tragedylooms-in-early-chaos-of-u-s-covid-19-vaccine-distribution 6. engel-smith lnc. health news. in the rural race to distribute covid vaccines, a piecemeal approach. february 10, 2021. https://www.northcarolinahealthnews.org/2021/02/10/in-therural-race-to-distribute-covid-vaccines-a-piecemeal-approach/ 7. national academies of sciences, engineering, and medicine, 2020. framework for equitable allocation of covid-19 vaccine. washington, dc: the national academies press. https://doi.org/10.17226/25917 8. flanagan be, gregory ew, hallisey ej, heitger jl, lewis b. 2011. a social vulnerability index for disaster management. journal of homeland security management. 8(1), 3. https://doi.org/10.2202/1547-7355.1792 9. duijzer le, van jaarsveld wl, wallinga j, dekker r. 2018. dose-optimal vaccine allocation over multiple populations. prod oper manag. 27(1), 143-59. doi:https://doi.org/10.1111/poms.12788. pubmed 10. flanagan be, hallisey ej, adams e, lavery a. 2018. measuring community vulnerability to natural and anthropogenic hazards: the centers for disease control and prevention’s social vulnerability index. j environ health. 80(10), 34-36. pubmed 11. chau ph, gusmano mk, cheng jo, cheung sh, woo j. 2014. social vulnerability index for the older people-hong kong and new york city as examples. j urban health. 91(6), 104864. doi:https://doi.org/10.1007/s11524-014-9901-8. pubmed https://doi.org/10.17226/25917 https://doi.org/10.2202/1547-7355.1792 https://doi.org/10.1111/poms.12788 https://pubmed.ncbi.nlm.nih.gov/32327917 https://pubmed.ncbi.nlm.nih.gov/32327766 https://doi.org/10.1007/s11524-014-9901-8 https://pubmed.ncbi.nlm.nih.gov/25216790 covid-19: a vaccine priority index mapping tool for rapidly assessing priority populations in north carolina 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(3):e13, 2021 ojphi 12. horney ja, nguyen m, cooper j, simon m, ricchetti-masterson k, et al. 2017. accounting for vulnerable populations in rural hazard mitigation plans: results of a survey of emergency managers. j emerg manag. 11(3), 201-11. doi:https://doi.org/10.5055/jem.2013.0138. pubmed 13. bakkensen la, fox-lent c, read lk, linkov i. 2017. validating resilience and vulnerability indices in the context of natural disasters. risk anal. 37(5), 982-1004. epub aug 2016. doi:https://doi.org/10.1111/risa.12677. pubmed 14. north carolina interim covid-19 vaccination plan. executive summary. october 16, 2020. accessed on december 18, 2020. https://files.nc.gov/covid/documents/nc-covid-19vaccine-plan-with-executive-summary.pdf 15. diabetes. centers for disease control and prevention. accessed august 18, 2020. https://www.cdc.gov/diabetes/index.html?cdc_aa_refval=https%3a%2f%2fwww.cdc.g ov%2fdiabetes%2fhome%2findex.html 16. cms medicare and medicaid chronic conditions data warehouse. accessed august 19, 2020. https://www2.ccwdata.org/web/guest/home/ 17. singh, g. area deprivation and widening inequalities in us mortality, 1969-1998. american journal of public health. july 203, vol 93 no 7, pp 1137-1143. 18. kind aj, jenks s, brock j, mengang y, bartels c, et al. 2014. neighborhood socio-economic disadvantage and 30-day rehospitalizations; an analysis of metadata. ann intern med. 161(11), 765-74. pubmed https://doi.org/10.7326/m13-2946 19. artiga s, ndugga n, pham o. immigrant access to covid-19 vaccines: key issues to consider. kaiser family foundation. january 13, 2021. accessed february 17, 2021. https://www.kff.org/racial-equity-and-health-policy/issue-brief/immigrant-access-to-covid19-vaccines-key-issues-to-consider/ 20. covid-19. centers for disease control and prevention. accessed august 18, 2020. https://www.cdc.gov/coronavirus/2019-ncov/community/health-equity/race-ethnicity.html 21. health equity considerations and racial and ethnic minority groups. centers for disease control and prevention. accessed september 12, 2020. https://www.cdc.gov/coronavirus/2019-ncov/community/health-equity/race-ethnicity.html 22. behavioral risk factor surveillance system. centers for disease control and prevention. accessed august 18, 2020. https://www.cdc.gov/brfss/index.html 23. covid data tracker. centers for disease control and prevention website. accessed december 2, 2021. https://covid.cdc.gov/covid-data-tracker/#datatracker-home https://doi.org/10.5055/jem.2013.0138 https://pubmed.ncbi.nlm.nih.gov/24180063 https://pubmed.ncbi.nlm.nih.gov/24180063 https://doi.org/10.1111/risa.12677 https://pubmed.ncbi.nlm.nih.gov/27577104 https://pubmed.ncbi.nlm.nih.gov/25437404 https://doi.org/10.7326/m13-2946 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts when it rains it pours: real-time situational awareness for two weather emergencies in connecticut kristen soto*, jaime krasnitski, therese rabatsky-ehr and matthew cartter epidemiology, connecticut department of public health, hartford, ct, usa objective to characterize the utility of the connecticut hospital emergency department syndromic surveillance (hedss) system for real-time situational awareness during two weather-related emergencies. introduction on august 28, 2011 tropical storm irene made landfall in connecticut. on october 29, 2011 connecticut was impacted by winter storm alfred. both of these storms included high winds and heavy precipitation which resulted in prolonged power outages, disruption of public drinking water systems, property damage, and widespread debris throughout the state. the hedss system was utilized to provide real-time situational awareness during the response and recovery phases of both storm events. methods the hedss system receives electronic patient abstract data from 21 of 32 emergency departments on a daily basis. free-text chief complaint data are characterized into syndrome categories. ed visits for carbon monoxide exposure (co), gastrointestinal illness (gi), injury, hypothermia, motor vehicle accidents (mva), and asthma syndromes were monitored throughout the response and recovery periods of both storm. odds ratios were calculated using the two weeks preand post-storm as reference dates. co visits were further assessed for geographic and demographic trends to target public health messages. the hedss system was evaluated to make recommendations for event monitoring during future public health emergencies. results following both storms there was a high completeness of daily hedss reporting despite extensive power outages (96% post-tropical storm, 91% post-winter storm). increased emergency department utilization for co (or: 26.20, 95% ci: 3.57-192.64) was observed post-tropical storm. increased emergency department utilization for co (or: 14.61, 95% ci: 7.43-28.72), hypothermia (or: 17.02, 95% ci: 3.01-359.30), and asthma (or: 1.17, 95% ci: 1.05-1.30) were observed following the winter storm. regional increases in ed utilization for injuries and mva were observed following both storm events; no increase in gi was associated with either storm event. during the 2 weeks post-tropical storm 28 cases of co exposure were reported through hedss and 5 cases through laboratory surveillance; during the winter storm 131 cases were reported through hedss and 162 through reportable disease surveillance. of the 167 cases reported through laboratory surveillance, 111 (66%) were from hospitals that sent data to hedss hospitals and 94(56%) were able to be matched to a specific ed record; of these 22(20%) were characterized as visiting the ed for co syndrome, 13(14%) had symptoms consistent with co as their chief complaint, 11(12%) had smoke/gasoline inhalation exposures as their chief complaint and 2(2%) had unrelated chief complaints. during the post-storm period the hedss systems detected 137 potential co exposures that were not reported through laboratory surveillance. conclusions tropical storm irene and winter storm alfred both had significant health impacts, particularly increased ed utilization for co due to prolonged power outages. the hedss system is the only all-hazards surveillance system that was able to provide near-real time information during the storm response phase. in addition to the current co syndrome definition, where the chief complaint must specifically mention the term co, a broader definition should also be used in the future to better assess the magnitude of co-related exposures. the broad definition should include symptomology and related exposures, such as smoke inhalation, to improve case detection. the hedss system should continue to be used in conjunction with reportable disease surveillance for situational monitoring during public health emergencies. keywords emergency department; public health practice; syndromic surveillance; carbon monoxide; weather acknowledgments patricia przysiecki, mph; brian toal, msph references 1.witt associates. connecticut october 2011 snowstorm power restoration report. december 21, 2011.http://www.wittassociates.com/assets/860/ctpowerrestorationreport20111201_final_1_.pdf *kristen soto e-mail: kristen.soto@ct.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e97, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts one health surveillance with electronic integrated disease surveillance system alexey v. burdakov*, andrey o. ukharov and thomas g. wahl black & veatch, overland park, ks, usa objective the objective of this demonstration is to show conference attendees how one-health surveillance in medical, veterinary and environmental sectors can be improved with electronic integrated disease surveillance system (eidss) using cchf as an example from kazakhstan. introduction eidss supports collection and analysis of epidemiological, clinical and laboratory information on infectious diseases in medical, veterinary and environmental sectors. at this moment the system is deployed in kazakhstan at 150 sites (planned 271) in the veterinary surveillance and at 8 sites (planned 23) in human surveillance. the system enforces the one-health concept and provides capacity to improve surveillance and response to infectious disease including especially dangerous like cchf. eidss has been in development since 2005 and is a free-of-charge tool with plans for open-source development. the system development is based on expertise of a number of us and international experts including cdc, wrair, usamriid, et al. methods effective monitoring and control of zoonotic diseases requires integrated approach to surveillance in medical, veterinary and environmental sectors. capability to rapidly collect and analyze information from these sectors is challenging due to diversity of different systems often used in these areas. eidss presented a unique integrated solution which allows collecting, sharing and analyzing data across these sectors. in those countries where this system is implemented both in human and veterinary surveillance (georgia, azerbaijan and kazakhstan), it provides a unique opportunity to improve monitoring and control capability. in kazakhstan and other countries experts are working on creating and improving effective analysis methods. in particular a method of real-time control of cchf situation was developed in kazakhstan. it allows the assembly of raw data gathered at the lower level in, surveillance system throughout the country on cchf cases in humans, assemble ticks vector surveillance campaigns and laboratory diagnostic results and analyze these data against population density. this gives a one-step tool to an epidemiologist to understand the situation and plan response at the national and regional level (see sample map). a quick link with the veterinary response teams allow to rapidly act with domestic animals prophylaxis measures. demonstration of the tool encouraging the one health approach to the surveillance which is already in place in a number of countries provides an exclusive opportunity to review different aspects of its utilization in practice as well as discuss challenges and benefits of this method in resource limited environments. conclusions eidss provides a capacity to improve one-health disease surveillance in human, veterinary and vector sectors by rapidly collecting, disseminating and analyzing data on infectious diseases. particular methods which are being developed in kazakhstan and other participating countries provide an instrument to epidemiologists to make decisions and more effectively plan response measures. currently particular methods were tested for cchf infection. it is planned to introduce methods for brucellosis and other infectious diseases of special interest in central asia and caucasus region. keywords eidss; electronic surveillance; one-health references 1. burdakov a., ukharov a. transforming national human and veterinary disease surveillance systems from paper into integrated electronic form in the fsu countries // 15th international congress on infectious diseases (icid), bangkok 2012 2. burdakov a., ukharov a. electronic integrated disease surveillance (eidss) // world congress on information and communication technologies for development (wcid’09) congress in beijing, china 2009 3. burdakov a. implementation of information-telecommunication part of the threat agent detection and response (tadr) program in republic of kazakhstan // official bulletin of state sanitary-epidemiological service of republic of kazakhstan, 1/37. 69-70. *alexey v. burdakov e-mail: burdakovav@bv.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e199, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts syndromic surveillance for outbreak detection and investigation tom andersson*1, 2, 4, pär bjelkmar3, anette hulth1, johan lindh1, stephan stenmark5 and mikael widerström6 1swedish institute for communicable disease control (smi), solna, sweden; 2national food agency, uppsala, sweden; 3inera ab, stockholm, sweden; 4stockholm university section for mathematical statistics, stockholm, sweden; 5västerbotten county medical officer, umeå, sweden; 6jämtland county medical officer, östersund, sweden objective for the purpose of developing a national system of outbreak surveillance, we compared local outbreak signals in three sources of syndromic data – telephone triage of acute gastroenteritis (swedish health care direct 1177), web queries about symptoms of gastrointestinal illness (stockholm county’s website for healthcare information), and otc pharmacy sales of anti-diarrhea medication. introduction a large part of the applied research on syndromic surveillance targets seasonal epidemics, e.g. influenza, winter vomiting disease, rotavirus and rsv, in particular when dealing with preclinical indicators, e.g. web traffic (hulth et al, 2009). the research on local outbreak surveillance is more limited. two studies of teletriage data (nhs direct) have shown positive and negative results respectively (cooper et al, 2006; smith et al, 2008). studies of otc pharmacy sales have reported similar equivocal performance (edge et al, 2004; kirian and weintraub, 2010). as far as we know, no systematic comparison of data sources with respect to multiple point-source outbreaks has so far been published (cf. buckeridge, 2007). in the current study, we evaluated the potential of three data sources for syndromic surveillance by analyzing the correspondence between signal properties and point-source outbreak characteristics. methods the extracted data streams were compared with respect to nine waterborne and foodborne outbreaks in sweden in 2007-2011. the analysis consisted of three parts: (1) the validation of outbreak signals by comparing signal counts during outbreak and baseline periods, (2) the estimation of detection limits by modeling signal rates (signalto-case ratios), and (3) the evaluation of early warning potential by means of signal detection analysis. results the four largest outbreaks generated strong and clear outbreak signals in the 1177 triage data. the two largest outbreaks produced signals in otc sales of anti-diarrhea. no signals could be identified in the web query data. the outbreak detection limit based on triage data was about 100-1000 cases. for two outbreaks, triage data on diarrhea provided outbreak signals early on, weeks and months respectively, potentially serving the purpose of early warning. conclusions the sensitivity and specificity were highest for telephone triage data on patient symptoms. it provided the most promising source of syndromic data for surveillance of point-source outbreaks. currently, a project has been initialized to develop and implement a national system in sweden for daily syndromic surveillance based on 1177 health care direct, supporting regional and local outbreak detection and investigation. keywords syndromic surveillance; outbreak detection; point-source outbreak; outbreak investigation; data analysis acknowledgments the study is part of an ongoing research and development project on syndromic surveillance (sumo) funded by the swedish agency for contingency planning (msb). references buckeridge dl. outbreak detection through automated surveillance: a review of the determinants of detection. j biomed inform. 2007 aug;40(4):370-9. cooper dl, verlander nq, smith ge, charlett a, gerard e, willocks l, o’brien s. can syndromic surveillance data detect local outbreaks of communicable disease? a model using a historical cryptosporidiosis outbreak. epidemiol infect. 2006 feb;134(1):13-20. edge vl, pollari f, lim g, aramini j, sockett p, martin sw, wilson j, ellis a. syndromic surveillance of gastrointestinal illness using pharmacy over-the-counter sales. a retrospective study of waterborne outbreaks in saskatchewan and ontario. can j public health. 2004 nov-dec;95(6):446-50. hulth a, rydevik g, linde a. web queries as a source for syndromic surveillance. plos one. 2009;4(2). kirian ml, weintraub jm. prediction of gastrointestinal disease with over-the-counter diarrheal remedy sales records in the san francisco bay area. bmc med inform decis mak. 2010 jul 20;10:39. smith s, elliot aj, mallaghan c, modha d, hippisley-cox j, large s, regan m, smith ge. value of syndromic surveillance in monitoring a focal waterborne outbreak due to an unusual cryptosporidium genotype in northamptonshire, united kingdom, june july 2008. euro surveill. 2010 aug 19;15(33):19643. *tom andersson e-mail: tom.andersson@smi.se online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e78, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts detection of patients with influenza syndrome using machine-learning models learned from emergency department reports arturo lópez pineda*, fu-chiang tsui, shyam visweswaran and gregory f. cooper university of pittsburgh. department of biomedical informatics, pittsburgh, pa, usa objective compare 7 machine learning algorithms with an expert constructed bayesian network on detection of patients with influenza syndrome. introduction early detection of influenza outbreaks is critical to public health officials. case detection is the foundation for outbreak detection. previous study by elkin el al. demonstrated that using individual emergency department (ed) reports can better detect influenza cases than using chief complaints [1]. our recent study using ed reports processed by bayesian networks (using expert constructed network structure) showed high detection accuracy on detection of influenza cases [2]. methods the dataset used in this study includes 182 ed reports with confirmed pcr influenza tests (jan 1, 2007-dec 31, 2009) and 40853 ed reports as control cases from 8 eds in upmc (jul 1, 2010-aug 31, 2010). all ed reports were deidentified by de-id software with irb approval. an nlp system, topaz, was used to extract relevant findings and symptoms from the reports and encoded them with the umls concept unique identifier codes [2]. two subsets were created: ds1-train (67% of cases) and ds1-test (remaining 33%). the algorithms used for training the models are: naïve bayes classifier, efficient bayesian multivariate classification (ebmc) [3], bayesian network with k2 algorithm, logistic regression (lr), support vector machine (svm), artificial neural networks (ann) and random forest (rf). the predictive performance of each method was evaluated using the area under the receiver operator characteristic (auroc) and the hosmer-lemeshow (hl) statistical significance testing, that describes the lack-of-fit of the model to the dataset. results the evaluation results of all the models using ds1-test, including the auroc, its confidence interval, p-value (between each algorithm and the expert) and the calibration with hl are shown in table 1. conclusions all models achieved high auroc values. the pairwise comparison of p-values in table 1 demonstrates that the aurocs of all the machine-learning models and the expert model were not significantly different. nevertheless, ebmc is the best fitted. the model created by ebmc is shown in figure 1. one limitation of the study is that the test dataset has low influenza prevalence, which may bias the detection algorithm performance. we are in the process of testing the algorithms using higher prevalence rate. the same process could also be applied to other diseases to further research the generalizability of our method. predictive performance and calibration area under the roc curve (auroc) with 95% confidence interval; pvalue relative to the expert model; and hosmer-lemeshow calibration statistic influenza syndrome model created using the ebmc algorithm keywords influenza; machine-learning; ed reports acknowledgments this research was funded by grant p01-hk000086 from the cdc in support of the university of pittsburgh center for advanced study of public health in informatics. the international fulbright s&t award and conacyt-mexico support alp. references [1] elkin, p. l., froehling, d. a., wahner-roedler, d. l., brown, s. h., & bailey, k. r. (2012). comparison of natural language processing biosurveillance methods for identifying influenza from encounter notes. annals of internal medicine, 156(1 pt 1), 11–18. [2] tsui, f.-c., wagner, m., cooper, g. f., que, j., harkema, h., dowling, j., sriburadej, t., et al. (2011). probabilistic case detection for disease surveillance using data in electronic medicalrecords. online journal of public health informatics, 1–17. [3] cooper, g. f., hennings-yeomans, p. p., & barmada, m. m. (2010). an efficient bayesian method for predicting clinical outcomes from genomewide data. amia 2010 symposium proceedings, 2010, 127–131. *arturo lópez pineda e-mail: arl68@pitt.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e41, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts collaborative automation reliably remediating erroneous conclusion threats (carrect) jonathan c. lansey*1, paul picciano1, ian yohai1, fred grant2 and robert gern2 1aptima inc., woburn, ma, usa; 2northrop grumman corporation, falls church, va, usa objective the objective of the carrect software is to make cutting edge statistical methods for reducing bias in epidemiological studies easy to use and useful for both novice and expert users. introduction analyses produced by epidemiologists and public health practitioners are susceptible to bias from a number of sources including missing data, confounding variables, and statistical model selection. it often requires a great deal of expertise to understand and apply the multitude of tests, corrections, and selection rules, and these tasks can be time-consuming and burdensome. to address this challenge, aptima began development of carrect, the collaborative automation reliably remediating erroneous conclusion threats system. when complete, carrect will provide an expert system that can be embedded in an analyst’s workflow. carrect will support statistical bias reduction and improved analyses and decision making by engaging the user in a collaborative process in which the technology is transparent to the analyst. methods older approaches to imputing missing data, including mean imputation and single imputation regression methods, have steadily given way to a class of methods known as “multiple imputation” (hereafter “mi”; rubin 1987). rather than making the restrictive assumption that the data are missing completely at random (mcar), mi typically assumes the data are missing at random (mar). there are two key innovations behind mi. first, the observed values can be useful in predicting the missing cells, and thus specifying a joint distribution of the data is the first step in implementing the models. second, single imputation methods will likely fail not only because of the inherent uncertainty in the missing values but also because of the estimation uncertainty associated with generating the parameters in the imputation procedure itself. by contrast, drawing the missing values multiple times, thereby generating m complete datasets along with the estimated parameters of the model properly accounts for both types of uncertainty (rubin 1987; king et al. 2001). as a result, mi will lead to valid standard errors and confidence intervals along with unbiased point estimates. in order to compute the joint distribution, carrect uses a bootstrapping-based algorithm that gives essentially the same answers as the standard bayesian markov chain monte carlo (mcmc) or expectation maximization (em) approaches, is usually considerably faster than existing approaches and can handle many more variables. results tests were conducted on one of the proposed methods with an epidemiological dataset from the integrated health interview series (ihis) producing verifiably unbiased results despite high missingness rates. in addition, mockups (figure 1) were created of an intuitive data wizard that guides the user through the analysis processes by analyzing key features of a given dataset. the mockups also show prompts for the user to provide additional substantive knowledge to improve the handling of imperfect datasets, as well as the selection of the most appropriate algorithms and models. conclusions our approach and program were designed to make bias mitigation much more accessible to much more than only the statistical elite. we hope that it will have a wide impact on reducing bias in epidemiological studies and provide more accurate information to policymakers. figure 1 screenshot of user selecting imputation parameters. keywords bias reduction; missing data; statistical model selection acknowledgments this material is based upon work supported by the walter reed army institute of research (wrair) under contract no. w81xwh-11-c-0505. any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the wrair. references james honaker and gary king, “what to do about missing values in time series cross-section data” american journal of political science vol. 54, no. 2 (april, 2010): pp. 561-581. gary king, james honaker, anne joseph, and kenneth scheve. “analyzing incomplete political science data: an alternative algorithm for multiple imputation”, american political science review, vol. 95, no. 1 (march, 2001): pp. 49-69. *jonathan c. lansey e-mail: jlansey@aptima.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e189, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluating syndromic data for surveillance of noninfectious disease ramona lall* and marc paladini new york city department of health and mental hygiene, queens, ny, usa objective to evaluate several non-infectious disease related syndromes that are based on chief complaint (cc) emergency department (ed) syndromic surveillance (ss) data by comparing these with the new york statewide planning and research cooperative system (sparcs) clinical diagnosis data. in particular, this work compares ss and sparcs data for total ed visits and visits associated with three noninfectious disease syndromes, namely asthma, oral health and hypothermia. introduction syndromic surveillance data has predominantly been used for surveillance of infectious disease and for broad symptom types that could be associated with bioterrorism. there has been a growing interest to expand the uses of syndromic data beyond infectious disease. because many of these conditions are specific and can be swiftly diagnosed (as opposed to infectious agents that require a lab test for confirmation) there could be added value in using the icd9 ed discharge diagnosis field collected by ss. however, ss discharge diagnosis data is not complete or as timely as chief complaint data. therefore, for the time being ss chief complaint data is relied on for non-infectious disease surveillance. sparcs data are based on clinical diagnoses and include information on final diagnosis, providing a means for comparing the chief complaint (from ss) to a diagnosis code (from sparcs), for evaluating how well the syndrome is captured by ss and for assessing if it would be advantageous to get ss ed diagnosis codes in a more timely and complete manner. methods syndromes previously developed by the dohmh were used for this work. syndrome definitions are based on querying the cc field in ss data for terms associated with asthma, oral health and hypothermia. the asthma syndrome consists of search terms for ‘asthma’, ‘wheezing’ and ‘copd’. the oral health syndrome uses (‘tooth’ or ‘gum’) and (‘ache’, ‘hurt’) and excludes visits resulting from trauma (e.g., ‘injury’, ‘accident’). the hypothermia syndrome is limited to search for the word ‘hypothermia’. for the purpose of comparison of the ss data with sparcs data for the three syndromes, the following icd9 diagnosis codes were considered in sparcs: 493 for asthma, 521-523, 525, 528-529 for oral health and 991 for hypothermia. ss and sparcs data for 2007 were used for this work as this was the most recent and complete sparcs ed dataset that was available. overall city-wide daily counts and hospital-level annual counts for total ed, asthma-, oral healthand hypothermia-related visits were computed for ss ed data and sparcs ed data. a comparison of daily and hospital trends for ss and sparcs for total and syndrome-related counts were conducted using correlation coefficients. results there is a high correlation between total ed ss and sparcs daily counts (r=0.98, p-value<0.001). on average, sparcs daily counts are higher by approximately 75 visits (range: -674, 591) per day. correlations between ss and sparcs daily counts for asthma, oral health and hypothermia were 0.96 (p-value<0.001), 0.66 (pvalue<0.001) and 0.45 (p-value<0.001), respectively. correlations between ss and sparcs hospital-level annual counts for asthma, oral health and hypothermia were 0.89 (p<0.001), 0.87 (p<0.001) and 0.07 (p=0.61). in 2007, less than 8% of individual ss records had a discharge diagnosis, and this was found to vary between hospitals (069%); therefore, a comparison between ss discharge diagnosis and sparcs diagnosis data was not possible. conclusions overall, syndromic surveillance data was found to be a useful data source for public health surveillance of non-infectious disease. total ed visits were found to be comparable between ss and sparcs. while direct comparison of counts for syndromes is not possible, the daily syndrome counts between ss and sparcs correlated well. however, the strength of correlation varied depending on the syndrome, with a better correlation for syndromes with larger volume of visits to the ed (e.g., asthma) and with more commonly used terms in the cc search (e.g., ‘tooth ache’) compared to syndromes with very specific search terms (e.g., ‘hypothermia’). in certain instances, it is hypothesized that ss discharge diagnosis would provide more reliable and representative estimates than cc for tracking non-infectious disease. future work will consider a period with more complete ss ed discharge diagnosis data for further comparisons and to test the hypothesis that more complete and timely ss ed discharge diagnosis data could improve surveillance efforts. keywords chief complaint; syndromic surveillance; new york city; non-infectious disease; discharge diagnosis acknowledgments data analysis and syndromic surveillance unit, bureau of communicable diseases *ramona lall e-mail: rlall@health.nyc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e163, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts #wheezing: a content analysis of asthma-related tweets gwendolyn gillingham*1, michael a. conway2, wendy w. chapman2, michael b. casale3 and kathryn b. pettigrew3 1linguistics, ucsd, la jolla, ca, usa; 2ucsd division of biomedical informatics, la jolla, ca, usa; 3west health institute, la jolla, ca, usa objective we present a content analysis project using natural language processing to aid in twitter-based syndromic surveillance of asthma. introduction recently, a growing number of studies have made use of twitter to track the spread of infectious disease. these investigations show that there are reliable spikes in traffic related to keywords associated with the spread of infectious diseases like influenza [1], as well as other syndromes [2]. however, little research has been done using social media to monitor chronic conditions like asthma, which do not spread from sufferer to sufferer. we therefore test the feasibility of using twitter for asthma surveillance, using techniques from nlp and machine learning to achieve a deeper understanding of what users tweet about asthma, rather than relying only on keyword search. methods we retrieved a large volume of tweets from the twitter api. search terms included “asthma,” and several misspellings of that word; terms for common medical devices associated with asthma such as “inhaler” and “nebulizer”; and names of prescription drugs used to treat the condition, including “albuterol” and “singulair.” a randomly sampled subset of these tweets (n=3511) was annotated for content, based on an annotation scheme that coded for the following elements: the experiencer of asthma symptoms (self, family, friend, named other, unidentified, and all-non-self, which was the union of these last four categories); aspects of the type of information being conveyed by each tweet (medication, triggers, physical activity, contacting of a medical practitioner, allergies, questions, suggestions, information, news, spam); as well as negative sentiment, future temporality, and non-english content. further details on the annotation scheme used can be found at http://idiom.ucsd.edu/!ggilling/annotation.pdf. inter-annotator agreement on a subset of the tweets (n=403) fell in an acceptable range for all categories (cohen’s kappa >0.6). once annotation was complete, the tweets’ texts were stemmed and converted into vectors of unigram and bigram counts. these were then stripped of sparse terms (all those words appearing in fewer than 1 in 200 tweets), which left multi-dimensional vectors consisting of the counts of the remaining words in all tweets. statistical machine-learning classifiers including k-nearest neighbors, naive bayes and support vector machines were then trained on the unigram and bigram models. results svm with 10-fold cross-validation achieved greatest prediction accuracy with the unigram model, as shown in table 1. categories that showed the greatest reduction in classification error using the unigram model were non-english, self, all-non-self, medication, symptoms and spam. the majority of these categories showed very high precision, as well as fairly high recall for the unigram model. unexpectedly, the bigram model faired far worse than the unigram model, which suggests that individual words in these tweets were more reliably predictive of content than pairs of words, which occurred less frequently. conclusions text-classification increases the utility of twitter as a data-source for studying chronic conditions such as asthma. using these methods, we can automatically reject tweets that are non-english or spam. we can also determine who is experiencing symptoms: the twitter user or another individual. fairly simple models are able to predict with good certainty whether a user is talking about their symptoms, their medication, or triggers for their asthma, as well as whether they are expressing negative sentiment about their condition. we demonstrate that social media such as twitter is a promising means by which to conduct surveillance for chronic conditions such as asthma. table 1: performance of classifiers on unigram and bigram models keywords social media; natural language processing; asthma; content analysis acknowledgments this work was financially supported by the west wireless health institute and idash summer internship program (nih u54hl108460). references 1. chew, c. & eysenbach, g. 2010. pandemics in the age of twitter: content analysis of tweets in the h1n1 outbreak. plos one 5(11): e14118. 2. collier, n. & doan, s. 2011. syndromic classification of twitter messages. proc. ehealth 2011, malaga, spain. november 21-23. *gwendolyn gillingham e-mail: gwen.gillingham@ling.ucsd.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e65, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts establishing a federal and state data exchange pilot for public health situational awareness dina b. passman*1, aaron kite-powell2, dara spector1, wayne loschen3, barry harp1, aaron chern2, janet hamilton2, cary eggers2 and joseph lombardo3 1u.s. department of health and human services, office of the assistant secretary for preparedness and response, washington, dc, usa; 2florida department of health, bureau of epidemiology, jacksonville, fl, usa; 3johns hopkins university applied physics laboratory, laurel, md, usa objective u.s. department of health and human services (hhs) office of the assistant secretary for preparedness and response (aspr) partnered with the florida department of health (fdoh), bureau of epidemiology, to implement a new process for the unidirectional exchange of electronic medical record (emr) data when aspr clinical assets are operational in the state following a disaster or other response event. the purpose of the current work was to automate the exchange of data from the aspr electronic medical record system emr-s into the fdoh electronic surveillance system for the early notification of community-based epidemics (essence-fl) system during the 2012 republican national convention (rnc). introduction aspr deploys clinical assets, including an emr system, to the ground per state requests during planned and no-notice events. the analysis of patient data collected by deployed federal personnel is an integral part of aspr and fdoh’s surveillance efforts. however, this surveillance can be hampered by the logistical issues of field work in a post-disaster environment leading to delayed analysis and interpretation of these data to inform decision makers at the federal, state, and local levels. fdoh operates essence-fl, a multi-tiered, automated, and secure web-based application for analysis and visualization of clinical data. the system is accessible statewide by fdoh staff as well as by hospitals that participate in the system. to improve surveillance aspr and fdoh engaged in a pilot project whereby emr data from aspr would be sent to fdoh in near realtime during the 2012 hurricane season and the 2012 rnc. this project is in direct support of healthcare preparedness capability 6, information sharing, and public health preparedness capability 13, public health surveillance and epidemiological investigation. methods in 2011, fdoh approached aspr about securely transmitting raw emr data that could be ingested by essence-fl during aspr deployments in the state. upon conclusion of an agreement for a date exchange pilot, data elements of interest from the aspr emr were identified. due to the modular design essence-fl microsoft sql databases were easily adapted by the johns hopkins university applied physics laboratory (jhu/apl) to add a new module to handle receipt of aspr emr data including code to process the files, remove duplicates and create associations with existing reference information, such as system-defined geographic regions and age groups. scripts were developed to run on the aspr server to create and send updated files via secure file transfer protocol (sftp) every 15 minutes to essence-fl. prior aspr event deployment data was scrubbed and sent to essence-fl as a test dataset to ensure appropriate receipt and ingestion of the new data source. results emr data was transmitted through a central server at aspr to essence-fl every 15 minutes during each day of the 2012 rnc (august 26-31). in essence-fl, configuration allowed the data to be queried, analyzed, and visualized similar to existing essencefl data sources. in all, data from 11 patient encounters were successfully exchanged between the partners. the data were used by aspr and fdoh to simultaneously monitor in near real-time onsite medical response activities during the convention. conclusions timely access to patient data can enhance situational awareness and disease surveillance efforts and provide decision makers with key information in an expedient manner during disaster response and mass gatherings such as the rnc. however, data are siloed within organizations. the collaboration between fdoh, aspr and jhu/apl made emr data sharing and analysis more expeditious and efficient and increased timely access to these data by local, state, and federal epidemiologists. the integration of these data into the essence-fl system created one location where users could go to access data and create epidemiologic reports for a given region in florida, including the rnc. to achieve these successes with partners in the future, it will be necessary to develop partnerships well in advance of intended data exchange. future recommendations include robust pre-event testing of the data exchange process and planning for a greater amount of lead-time between enacting the official agreement and beginning data exchange. keywords syndromic surveillance; public health informatics; data exchange; federal and state collaboration *dina b. passman e-mail: dina.passman@hhs.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e48, 2013 advanced querying features for disease surveillance systems 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 advanced querying features for disease surveillance systems mohammad r. hashemian 1 1 the johns hopkins university applied physics laboratory abstract: most automated disease surveillance systems notify users of increases in the prevalence of reports in syndrome categories and allow users to view patient level data related to those increases. occasionally, a more dynamic level of control is required to properly detect an emerging disease in a community. dynamic querying features are invaluable when using existing surveillance systems to investigate outbreaks of newly emergent diseases or to identify cases of reportable diseases within data being captured for surveillance. the objective of the advance querying tool (aqt) is to build a more flexible query interface for most web-based disease surveillance systems. this interface allows users to define and build their query as if they were writing a logical expression for a mathematical computation. the aqt allows users to develop, investigate, save, and share complex case definitions. it provides a flexible interface that accommodates both advanced and novice users, checks the validity of the expression as it is built, and marks errors for users. keywords— public health informatics, population surveillance, disease outbreaks, software tools introduction in its 2007 annual report, the world health organization warned of the increased rate at which diseases spread in a world where 2 billion people travel by air [1]. the early detection of known and emerging illnesses is becoming more important. automated disease surveillance systems have been in existence for over 10 years [2-4]. most of these systems analyze data by syndrome and search for disease outbreaks. a syndrome in this context is defined as a group of diseases related in some fashion, such as respiratory diseases. this level of investigation is often sufficient, but a more dynamic level of control may be required to understand an emerging illness in a community. for example, during the 2002–2003 severe acute respiratory syndrome (sars) disease epidemic [5], the respiratory syndrome definition used by most automated disease surveillance systems was too broad to track sars [6]. in this case, the users needed to create queries that looked for specific keywords in the patient chief complaint or specific combinations of icd-9 codes [7]. a chief complaint is text entered by a triage professional in an emergency room or a advanced querying features for disease surveillance systems 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 clinic, based on a patient‟s description of their primary symptoms. today‟s public health departments must deal with a multitude of data coming from a variety of sources. for example, electronic medical record (emr) data include sources such as radiology, laboratory, and pharmacy data. a more sophisticated querying tool is needed to assist investigators with creating inquiries across multiple data sources [8-10]. currently, there are surveillance systems, such as the electronic surveillance system for the early notification of community-based epidemics (essence) [11], which provide limited dynamic querying capability. however, we wanted to design a flexible and simple graphical user interface (gui) for this and other types of surveillance systems. our prototype system, the advanced querying tool (aqt), allows the investigators to handle complex cases where one can incorporate any data elements available in a disease surveillance system, then mix and match these data elements in order to define valid queries. hence, this system removes the need for database administrators and application developers to define pre-packaged database queries and user interfaces every time a new and innovative query is written. as an example, investigating a potential influenza outbreak in an adult population may require respiratory syndrome queries only, while investigating a similar outbreak in children under 4 years old may involve queries in both gastrointestinal and respiratory syndromes (figure 1). figure 1. running multiple inquires as one query table 1 provides examples of how a dynamic query tool exploits combinations of data elements available to disease surveillance systems. most automated disease surveillance systems have a fixed number of predefined syndromes. these applications severely limit the surveillance system value for diseases that fall outside of its broad syndrome categories. the background noise level rises when all the chief complaints that potentially fall into a syndrome category are included, which in turn requires many more positive cases to identify an abnormal condition. merely adding sub-syndrome categories, that are more granular than syndromes and cover a broader range of conditions than typical syndromic surveillance like injures and chronic disease [12], provides the users with a more comprehensive means to filter the analysis window. if a disease surveillance system has 400 sub-syndromes, then taken singly the user has 400 additional choices; by combining two or three sub-syndromes, the analysis options are magnified to over ten million choices. of course not all of these options are sensible, so the actual number of advanced querying features for disease surveillance systems 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 options is somewhat less. even greater analytic flexibility is provided through the use of data elements contained within electronic medical records. the capability to select a combination of a microbiology laboratory result, radiology result, and icd-9 code provides for a powerful tool that enables the public health community to rapidly identify specific high risk patients. table 1. potential analysis combinations using multiple data sources in combinations data type single items double combinations triple combinations total analysis choices syndromes 10 na na 10 sub-syndromes 400 79,800 10,586,800 10,667,000 advanced query tool: icd-9 codes 1,000 499,500 166,167,000 166,667,500 laboratory tests 300 44,850 4,455,100 4,500,250 radiology 100 4,950 161,700 166,750 prescription drugs 10,000 49,995,000 1.67e+11 1.66667e+11 icd-9 +lab+rad+prescr 11,400 50544300 1.66787e+11 1.66838e+11 objectives the following objectives summarize the design features of the aqt: the tool‟s interface will help generate queries that can process any kind of data regardless of its source (e.g., emergency room visit, office visit, pharmacy, and laboratory). unlike fixed-form query interfaces, aqt will not restrict users in what they can query. instead, the user will be able to formulate ad-hoc queries across assorted data sources without the need to understand the underlying data models and the query languages associated with different systems. in addition, using this tool should save investigators‟ valuable time in obtaining the query results. currently, if the surveillance system cannot generate the desired queries, the application developers and/or database administrators may have to create new interfaces or functionalities. the aqt, however, empowers the users to move forward with their research without waiting for developer or administrator modifications to the surveillance systems. the interface will accommodate users with different levels of experience in creating complex and valid queries. the process will be natural and follow the same patterns that one uses to express a mathematical equation. at the same time, it will give the more experienced users, who are familiar with the data elements, the freedom to define complex queries by advanced querying features for disease surveillance systems 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 sidestepping the guiding tools. the advanced users will have the ability to type in their queries and the tool will validate them and provide feedback on possible syntax errors. the interface will allow users to save and share queries with other public health professionals, even in different jurisdictions. after defining a complex query the user has the ability to store the query for future investigations. one should be able to execute the stored query repeatedly in the future, include it as a segment of a bigger query, or customize and execute it. these saved queries can then be shared as part of collaborative efforts among users in different departments and jurisdictions. aqt will provide an interface for disease surveillance systems to store, retrieve, and share queries. these capabilities are especially valuable for users employing a case definition for following a disease outbreak. a case definition is a set of symptoms, signs, etc., by which public health professionals define those patients considered to be directly a part of the disease outbreak. finally, the tool should be self-contained and generic. this allows most web-based disease surveillance systems to incorporate the aqt into their systems. methods interface the entire functionality of the tool is placed within a single web page (figure 2). figure 2. advanced querying tool interface advanced querying features for disease surveillance systems 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 the screen in figure 2 is divided into 5 major sections. starting at the top, the user can filter the data by picking the data source from a dropdown list, start and end date. the surveillance system should supply this list of data sources to the aqt. the next area below is the message area where the gui communicates with the user. any information, warnings, or error messages are displayed in this section. the next area, the query section, contains the query expression. the users can either directly type the query expression or use the tool to generate the query expression and paste it in this area. alternatively, they can use a combination of the two methods by typing part of the expression and pasting the rest using the query builder. the query section is followed by the query builder section where the tool provides list boxes, buttons, etc., to direct the user through the process of generating the query expression. the bottom section is where an action on the query is performed. users can validate the expression‟s syntax, save the query for their own future use, save it to be shared with others in the user community, clear the query expression and start over, or simply execute the query and get the results. data source as mentioned earlier, the capability to generate queries on data from a variety of sources is one of the objectives of the aqt. each data source has its own distinctive set of data elements. the interface has to provide a list of data elements pertaining to the chosen data source. for example, the data might represent different geographic regions from one data source to the other. that is, one source might have data identified by zip codes while another source uses some other type of defined region such as hospitals, pharmacies, and schools. another area where data sources can be different is in medical groupings. for example, office visits often use icd-9 codes [7], while emergency departments use patient chief complaints. the interface is designed to distinguish valid data elements for each data source and populate the data element list box accordingly. after selecting a data source the tool populates a list box with a set of associated data elements for the data source. the list box is divided into three major areas: the geography system the medical grouping system others such as age, sex, saved and shared queries. figure 3 shows how the medical grouping systems differ for emergency room (right) and over the counter (left) data sources. advanced querying features for disease surveillance systems 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 3. different data elements for each data source flexibility as mentioned earlier, a main objective of the aqt is to provide an interface that caters to both novice and experienced users. the experienced users simply type the query, while beginners and those who are more comfortable with a guided interface can use list boxes and buttons to generate the queries. in fact, one can type part of the query and use the tool to generate the rest of the query (figure 4). when a user types a query directly, it is assumed that the user knows the syntax and valid data elements pertaining to the data source, though the tool does check the syntax and provide feedback. advanced querying features for disease surveillance systems 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 4. generate query expression because we want the users to define and build their query as if they were writing a logical expression for a mathematical computation, the syntax is simple and close to the “where” clause of a structure query language (sql) statement. however, one does not need to know sql to write the expressions. a query consists of one or more simple expressions joined by “and” and/or “or,” negated by “not,” and grouped by parentheses. a simple expression is enclosed within square brackets ([]) and defined by a variable, a logical operator, and a value. for example, if an investigator is searching for reported fever cases within a specified zip code, the query then consists of two simple expressions; one which searches for the specified zip code and the other which checks the fever syndrome. the final query may look like the expression below: [zipcode=“21043”] and [syndrome=“fever”] if the investigators want to narrow the search into a certain age group they can type or use the tool to add and [age = “0-4”] to the above expression. hence, the users can add more conditions without worrying about the underlying data model. the most complex part of the syntax occurs when searching for values that contain, start with, or end with a set of characters (figure 5). in this case, the syntax uses “*” as the wildcard character. for example, a user would type [chief-complaints = “*head*”] in the query box if he/she is looking for all the records of chief-complaints that include the word “head.” similarly, if a user types [chief-complaints = “head*”] or generates it using the tool (selects the starts with from the operator list box and types head in the text field), the resulting query would search for all the records where the chief-complaints field begins with the word “head.” figure 5. wildcard in expressions advanced querying features for disease surveillance systems 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 natural flow the procedure for generating expressions follows the same pattern a person would use to create a logical expression. the interface will provide a natural flow to help the users to create an expression as if they are typing it. they may start with selecting a data element or variable such as „sex‟, then a logical operator like „=‟, and finally a value like „male‟ or „female‟. the user can add „and‟ or „or‟ and create the next expression using this same process. the user can interject expressions in the middle of a query, remove parts of the query, or undo the last change made to the query. as changes are being made, the tool validates the entire query in the background and provides instant feedback. this method of constructing queries is more intuitive to the users than that of creating all the individual expressions first and then joining them together. once the data source is selected, a list of core data elements is provided in a list box. from the list box the user can select a data element. based on the type of the data element, a list of valid logical operators for that data element is placed in another list box. figure 6 shows the list of valid operators for text fields. figure 6. valid operators for long text fields in cases such as zip code and syndrome, „=‟ and „<>‟ operators are also valid. for age the operators „>‟, „<‟, „<=‟, and „>=‟ are added to the list. once the user selects a data element, a list of valid values pertaining to the data element is listed in yet another list box. the user can select one or more of these values, and if more than one value is selected the user can choose to group these values using „and‟ or „or‟. note that the aqt generates the expression in a left to right progression in the same manner as one typing the expression (figure 7). advanced querying features for disease surveillance systems 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 7. select multiple values the next step is to add this expression to the query. by clicking on the “add expression” button, the expression is pasted at the cursor location in the query area. one can add more expressions to this query by clicking and or or buttons and following the same process (figure 8). figure 8. add expressions to the query the aqt helps users quickly identify limits for variables with large sets of values. because data elements such as zip codes and icd-9 codes have a lot of values for dropdown lists, finding a particular value in these list boxes is very cumbersome. the tool provides an intermediate step for filtering these options into a more manageable list (figure 9). for example, if the investigators are interested in data from certain zip codes in a state, they can reduce the options by typing the first two digits of the zip code and thereby filtering the list. advanced querying features for disease surveillance systems 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 9. filter value list validation the tool will generate valid expressions and provide a mechanism to check the query expressions when a user types parts or all of them. every time an expression is generated by the tool and the add expression button is clicked, the tool examines the entire query expression, checking it against the syntax rules. before saving or executing the expression the aqt automatically checks the syntax and if it detects any syntax errors it will provide meaningful error messages in the message area (figure 10). additionally, at any point the user can click on the validate button and check the syntax. figure 10. validate the query expression save and share queries frequently, investigators want to execute a query over time, run the same query with different values, or use the query inside more complex queries. similarly as all the other data elements (zip code, syndrome, region, etc.), the permanent storage and retrieval of queries (file system, database, or any other mechanism) are the responsibility of the disease surveillance system. the aqt is merely an interface to assist the investigators with their research by hiding the complexity and inner workings of the underlying data model. advanced querying features for disease surveillance systems 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 once the users define the desired query they can click on [save public expression] or [save private expression] buttons. if the query is valid, the screen provides an area to enter a unique name for the query (figure 11). figure 11. saved and shared queries if the query is successfully validated the aqt passes the name and query expression to the surveillance system. it is the surveillance system‟s responsibility to confirm that the query‟s name is unique and provide feedback to the aqt the success or failure of the save operation. based on the feedback received the aqt provides an appropriate message in the message area. in a collaborative environment users would like to share their findings and queries with others. providing the capability to save and share the queries for collaborative use enables others in the user community to run these queries as they are or to make the modifications necessary to help with their own investigations. the aqt facilitates saving public queries by providing an interface similar to saving private queries (figure 11). the surveillance system should implement the inner workings of the permanent storage and retrieval of public queries. the next step is retrieving these saved queries. there are two options in the data element list box in the query builder section of the aqt: one option is for retrieving the private saved queries, and the other option is for retrieving public saved queries (figure 12). upon selection of either one, a list of corresponding queries will be presented to the users. this list includes the text of the query and the unique name given to that query. by clicking on the query name the saved query will be added to the expression in the query area. advanced querying features for disease surveillance systems 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 figure 12. retrieve saved public and private queries at this point users can add more conditions to the same query, such as specifying a zip code, changing the value for age, etc. portability the final objective of this project is for the aqt to have the capability to be used with most web-based surveillance systems. one can think of the aqt as a widget, or an add-on with some defined interfaces. the back end can be implemented in a variety of popular technologies such as .net, java servlet, or any other server technology as long as it can communicate via an http protocol. the surveillance system has to provide the interfaces that supply values for the different parts of the screen, and the functionality to parse the final query text and run it against the underlying database. making the tool adaptable to many web-based systems requires the aqt to contain all the processing dynamically, including validating the query syntax and changing the contents of the list boxes. in a web-based environment, this means using browser components such as html, cascading style sheets (css) [13], javascript, and the document object model (dom) [14] to implement application logic. in developing aqt, we utilized html, javascript, and ajax (asynchronous javascript and xml) and placed all the processing on the local machine to avoid any server dependency. we used javascript to apply validation, data handling, and screen processing on the browser side, and ajax for communicating with server applications. ajax is used for creating interactive web applications and is a cross-platform technique usable on many different operating systems, computer architectures, and web browsers, because it is based on open standards such as javascript and xml. the intent of this technique is to make web pages more responsive by exchanging small amounts of data with the server behind the scenes, so that the entire web page does not have to be reloaded each time the user requests a change. this feature increases the web page‟s interactivity, speed, functionality, and usability. ajax is asynchronous in that loading does not interfere with normal page loading. advanced querying features for disease surveillance systems 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 the aqt uses ajax calls to obtain required data for populating the different list boxes on the screen. for example, when the user selects a data source the tool calls the surveillance system, passes the selected data source, gets a list of data elements from the server (the surveillance system), and then populates the data element list box. the communication to the server is done by an ajax call, and the javascript processes the returned data and populates the list. implementation essence has been one of the early adaptors of aqt. although the capability to create efficient custom queries for emergency room chief complaints data existed prior to the aqt, the query building process was cumbersome and not user-friendly. it was easy to make syntax errors while typing a query, and there was no mechanism to validate the logic of the query statement. furthermore, while “and” and “or” and “andnot” expressions were possible, there was no method to construct complex boolean operations with parentheses to clarify the order of operations. the previous capability allowed the user to base the custom query on data source, geography system, or medical grouping system, however, since the selections were not part of the query statement they could not be modified without returning to the pre-selection screens and re-starting the query process. additionally, the original capability did not allow for querying of data beyond the fundamental chief complaints-level. the following screen shot shows the query options that were available with the original feature. a sample chief complaints query designed to capture influenza-like-illness is shown in figure13. figure 13. influenza-like-illness query the aqt not only contains several capabilities that were not previously available, but also provides an intuitive user-friendly interface that allows the user to build simple or highly ^cough^,and,^fever^ ,or,^sorethroat^,and, ^fever^,andnot, ^asthma^ advanced querying features for disease surveillance systems 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 complex queries more easily. two new features in the aqt are parentheses, which allow the user to clarify the order of operations, and the ability to select variables such as region, zipcode, hospital, syndrome, sub-syndrome, chief complaint, age, and sex, as part of the query statement. this allows for easy query modifications. additionally, the aqt lets the user query data beyond the fundamental chief complaints level into a more sensitive sub-syndrome or syndrome level. it also allows users to develop queries that contain combinations of chief complaints, syndromes, and sub-syndromes into one query. the query can also contain combinations of different geographies such as zipcodes and regions. this capability is not available without aqt. during the query building process the aqt automatically validates the logic of query expression as it is created, and the user has the option to conduct a final validation prior to executing the query. this feature allows the user to quickly identify syntax errors and correct them before adding further complexity or executing the query. the following screen shot (figure 14) shows the query options available within the aqt feature. a sample chief complaints query designed to capture influenza-like-illness in region_a is shown. figure 14. influenza-like-illness query for region a advanced querying features for disease surveillance systems 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 conclusions we believe that the aqt will provide an interface that can assist public health investigators in generating complex and detailed case definitions. the interface supports saving queries for future use and sharing queries with others in the user community. the interface is intuitive and accommodates both novice and experienced users. finally, the aqt is a selfcontained tool that can be plugged into most web-based disease surveillance systems with relative ease. acknowledgements the author would like to express his appreciation to colleen martin and jerome tokars of the u.s. centers for disease control and prevention, to sanjeev thomas of science applications international corporation, and to wayne loschen, joseph lombardo, jacqueline coberly, rekha holtry, and steven babin of the johns hopkins university applied physics laboratory. conflict of interest statement the author declares that he has no competing interests. summary table what was already known on the topic early detection of known and emerging illnesses is becoming vital with the increased rate at which diseases spread world-wide. most automated disease surveillance systems analyze data by syndrome and look for disease outbreaks within a community, hence overlooking the diseases that fall outside of the broad syndrome categories. what this study added to our knowledge electronic disease surveillance systems need a more sophisticated querying tool to assist public health investigators in conducting inquires across multiple data sources. superior analytic flexibility through the use of data elements contained within electronic medical records enables the public health community to rapidly identify specific high risk patients. the advanced querying tool (aqt) was designed as a flexible and simple graphical user interface (gui) that allows users to develop, investigate, and share complex case definitions. advanced querying features for disease surveillance systems 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 1, 2010 references [1] world health organization. the world health report 2007 a safer future: global public health security in the 21st century. geneva, switzerland, world health organization press, 2007, p. 38. [2] vacalis t, bartlett c, shapiro c. electronic communication and the future of international public health surveillance. emerg. infect. dis. 1995; 1(1):34-35. http://dx.doi.org/10.3201/eid0101.950108 [3] teutsch s, thacker s. planning a public health surveillance system. epidemiol. bull. 1995; 16(1):1-6. [4] farrington c, andrews n, beale a, catchpole m. a statistical algorithm for the early detection of outbreaks of infectious disease. j. r. statist. soc. a. 1996;159(3):547-563. http://dx.doi.org/10.2307/2983331 [5] zhong n, zheng b, li y, poon l, xie z, chan k, et al. epidemiology and cause of severe acute respiratory syndrome (sars) in guangdong, people‟s republic of china, in february, 2003. lancet. 2003; 362:1353-1358. http://dx.doi.org/10.1016/s0140-6736(03)14630-2 [6] shih f-y, yen m-y, wu j-s, chang f-k, lin l-w, ho m-s, et al. challenges faced by hospital healthcare workers in using a syndrome-based surveillance system during the 2003 outbreak of severe acute respiratory syndrome in taiwan. infect. control and hosp. epidemiol. 2007; 28(3):354-357. http://dx.doi.org/10.1086/508835 [7] hart a, hopkins c, editors. 2003 icd9cm expert for hospitals, 6th ed. salt lake city (ut): st. anthony publishing; 2003. [8] bates d, gawande a. improving safety with information technology. new england journal of medicine. 2003; 348: 2526-2534. http://dx.doi.org/10.1056/nejmsa020847 [9] hillestad r, bigelow j, bower a, girosi f, meili r, scoville r, et al. can electronic medical record systems transform health care? potential health benefits, savings, and costs. health affairs. 2005; 24(5):1103-1117. http://dx.doi.org/10.1377/hlthaff.24.5.1103 [10] miller r, sim i. physicians‟ use of electronic medical records: barriers and solutions. health affairs. 2004; 23(2):116-126. http://dx.doi.org/10.1377/hlthaff.23.2.116 [11] lombardo j, burkom h, pavlin p. essence ii and the framework for evaluating syndromic surveillance systems. mmwr morb mortal wkly rep. 2004 sep 24; 53(suppl.):159-165. [12] standardizing clinical condition classifiers for biosurveillance. available at http://www.cdc.gov/biosense/files/phin2007_subsyndromespresentation-08.22.2007.ppt [13] mcfarland ds. css: the missing manual. sebastopol (ca): o‟reilly; 2006. [14] flanagan d. javascript: the definitive guide, 5th ed. sebastopol (ca): o‟reilly; 2006. author mohammad r. hashemian, ms (computer science) the johns hopkins university applied physics laboratory 11100 johns hopkins road laurel, md 20723 usa mohammad.hashemian@jhuapl.edu fax number: 443-778-3686 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts regional study of anthrax foci marina nikolaishvili*, marina zakareishvili, irma beradze, m donduashvili, nino vepkhvadze, lela kerdzevadze and maka kokhreidze laboratory for the ministry of agriculture, tbilisi, georgia objective the purpose of this study was to describe anthrax foci along the georgia-azerbaijan border and to describe control measures in identified areas. introduction anthrax is endemic in the south caucasus region. there is a lack of understanding of the regional epidemiology of the causative pathogen, bacillus anthracis, and the trans-boundary factors related to its persistence. methods to increase the local and regional understanding of anthrax ecology, ecological risk factors, and the genetic relationships and distribution among georgian and azerbaijani b. anthracis strains, a regional study of the ecology of anthrax foci was conducted in georgia and azerbaijan. six regions in georgia (that border azerbaijan) were selected for environmental sampling based on historical data. soil samples were collected in lagodekhi and sagarejo and tested at the laboratory of the ministry of agriculture using standard bacteriological and molecular biology methods. results a total of 185 soil samples were collected. bacteriological tests revealed four positive samples from kakheti (two from lagodekhi, gelati; two from dedoplistskaro), from which, cultures were isolated and confirmed by pcr. georgian scientists continue collecting and testing soil samples. after sample collection and bacteriological testing is completed, the molecular characteristics of the pathogen will be examined. conclusions this study will assist in the formulation of targeted public health interventions aimed at increasing knowledge of the disease within specific demographics. public health interventions can focus on livestock surveillance and control in identified areas. keywords anthrax; one health; endemic; trans-boundary; public health acknowledgments the research study described in this presentation was made possible by financial support provided by the us defense threat reduction agency. the findings, opinions and views expressed herein belong to the authors and do not reflect an official position of the department of the army, department of defense, or the us government, or any other organization listed. *marina nikolaishvili e-mail: marina.nikolaishvili@lma.gov.ge online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e158, 2017 generation of analysis of personal contact graphs models for use in infection control agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 agent based modeling of “crowdinforming” as a means of load balancing at emergency departments ryan neighbour 1 , luis oppenheimer 1,2 , shamir n. mukhi 1,3 , marcia r. friesen 1 , robert d. mcleod 1 1 university of manitoba 2 winnipeg regional health authority 3 public health agency of canada abstract this work extends ongoing development of a framework for modeling the spread of contacttransmission infectious diseases. the framework is built upon agent based modeling (abm), with emphasis on urban scale modelling integrated with institutional models of hospital emergency departments. the method presented here includes abm modeling an outbreak of influenza-like illness (ili) with concomitant surges at hospital emergency departments, and illustrates the preliminary modeling of ‘crowdinforming’ as an intervention. ‘crowdinforming’, a component of ‘crowdsourcing’, is characterized as the dissemination of collected and processed information back to the ‘crowd’ via public access. the objective of the simulation is to allow for effective policy evaluation to better inform the public of expected wait times as part of their decision making process in attending an emergency department or clinic. in effect, this is a means of providing additional decision support garnered from a simulation, prior to real world implementation. the conjecture is that more optimal service delivery can be achieved under balanced patient loads, compared to situations where some emergency departments are overextended while others are underutilized. load balancing optimization is a common notion in many operations, and the simulation illustrates that ‘crowdinforming’ is a potential tool when used as a process control parameter to balance the load at emergency departments as well as serving as an effective means to direct patients during an ili outbreak with temporary clinics deployed. the information provided in the ‘crowdinforming’ model is readily available in a local context, although it requires thoughtful consideration in its interpretation. the extension to a wider dissemination of information via a web service is readily achievable and presents no technical obstacles, although political obstacles may be present. the ‘crowdinforming’ simulation is not limited to arrivals of patients at emergency departments due to ili; it applies equally to any scenarios where patients arrive in any arrival pattern that may cause disparity in the waiting times at multiple facilities. keywords—contact graphs, agent based models, infection spread models agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 introduction the worldwide h1n1 influenza pandemic (ph1n1) in 2009 and 2010 has mobilized and renewed research attention to the many facets of infection control and impact, ranging from the epidemiology of the illness, development and deployment of vaccines and other pharmaceutical interventions, and public health and emergency management measures. predicting how an infection may spread within a population and the consequent impact that it may have includes forecasting with intelligent models and real data, as well as back-casting based on available data as one validation process. the focus of this paper is to present a computer simulation framework (model) of an urban community to model the spread of ph1n1 in the community, in which the model carries the capacity to model the impact of various intervention strategies, e.g. temporary clinics, vaccination, chemoprophylaxis, hygienic and social distancing measures. the intervention of direct interest in the present study is to provide the public with additional information related to expected waiting times at regional hospital emergency departments (eds), and its potential impact on patient loads and consequent service delivery. a true metric associated with estimating expected wait times at a particular hospital is a random variable of many factors and difficult to estimate even with extensive ed data. the work here demonstrates the role that patient redirection can play if this metric were available. in the interim, we have associated the number of patients with a ‘busyness’ metric that would be amenable for presentation to the community. as the social dynamics and agent behaviours coupled with real data (economic, cultural, and social) become better defined, the computer simulation naturally allows one to focus on the population subsets and apply the framework to other jurisdictions. the work is located within the larger context of healthcare informatics. the role of informatics in healthcare re-engineering and optimization has become a new reality in efforts to improve service delivery and efficiencies in healthcare. both well vetted engineering approaches as well as emerging methods are being applied to generate solutions for health policy and decision makers. new service delivery paradigms are developed and justified from a variety of domains, including statistics, operations research and lean manufacturing concepts from industrial engineering, and business models [1]-[5]. in healthcare, the challenge is exacerbated by the inherent unpredictability of social behaviour; this contributes to the computational irreducibility of the problems encountered within many healthcare environments. as a consequence, modeling and simulation are playing a larger role as a design aid or tool in support of decision making [6][9]. background the computer simulation framework is built, in part, on an agent-based model/modeling (abm) approach. a central premise of this work is that abms – combined with real data and as high a resolution (fidelity) as the computer system affords – will create a new paradigm for a better understanding of epidemiology within a social system dynamics, and thereby lead to more effective tools for policy makers guiding the future. abm is a relatively new approach to disease modeling (10+ yrs), an area historically addressed by well-vetted mathematical modeling techniques (70+ yrs). however, the use of abm for simulating infection spread within an urban area and built upon the incorporation of real data is only now emerging (2+ yrs). abm is based on simulating a collection of agents – i.e. the people in the model – in terms of their agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 characteristics, behaviours, and interactions with other agents. agents (people) are purposeful and autonomous entities able to assess their situations, make decisions and compete with one another. abm’s conceptual depth is derived from its ability to model emergent behaviour that may be counterintuitive, and to discern a complex behavioural whole that is greater than the sum of its parts. counterintuitive or counter intent behaviour may arise from non-obvious non-linear feedback loops that may exacerbate system dynamics, such as financial incentives to remain working while infected, or non-obvious pressures within the healthcare system that strain the system to its breaking point. complex behaviour that is greater than the sum of its parts may be associated with an agent’s ability to learn or make heuristic-based adaptations to their behaviours. abm provides a natural description of a system that can be calibrated and validated by representative expert agents (healthcare specialists), and is flexible enough to be tuned to high degrees of specificity (sensitivity) in agents’ behaviours and interactions. abms are particularly well suited to system modeling in which agent behaviour is complex, non-linear, stochastic, and may exhibit memory or path-dependence [10][11][12]. early application areas of abm include logistics, economics, and transportation systems. abm also provides one of the most useful tools available in terms of knowledge transfer and requirements capture, independent of whatever other techniques may also be employed. the model construction forces ideas to be clarified; unclear and hidden assumptions are exposed and debated in a common and familiar lexicon, leading to the abm having a direct correspondence to the problem as understood by the practitioner and the developer. the resulting model closely resembles the system description, which could come from business rules or some other description by stakeholders who need not be overly familiar with abm itself. many abms are developed to gain a better understanding of operations through the use of what-if scenarios, and in doing so will provide a decision support tool to public health decision-makers. a more recent and considerable area of application for abms has been country scale (community-level) disease spread modeling in human populations [13][14]. the focus generally constitutes large scale community-level epidemics of respiratory infections, as this is an important public health and policy issue with far-ranging health and economic impacts. our own work has included the development of one of the first urban-level epidemic proof-of-concept abms, based on a paradigm of a ‘discrete space scheduled walker’ (dssw) [15]. the urban scale abm is one of the most appropriate modeling levels in terms of incorporating high resolution data (individual based), as well as for simulating social dynamics reinforced by patterns of behaviour and readily available topographical data. the proof-of-concept is built on synthesized data and a very limited range of agent parameters. it can model a medium-sized north american city using approximately 650,000 discrete agents (people), each of whom are assigned a demographic profile and a weekly schedule on the topography of the city of winnipeg, canada. running the simulation with these types of numbers however is computationally tasking for a reasonable desktop environment. the proof-of-concept was built upon a conceptual framework of statistical reasoning (law of large numbers, statistical mechanics) as well as a correct-by-construction bias, meaning that the system dynamics emerge directly out of the agents’ characteristics and behaviours, rather than by the inclusion of artificial small-world networks. the proof-of-concept addresses where, who, when, and what elements. where: underlying topographical (network / graph) data is extracted from map and search engine utilities such as google earth, in order to build a network of objects, denoted institutions. agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 institutions are existing geographic locations such as homes, businesses, schools, leisure sites, hospitals, airport, and transport vehicles. who: agents are people that make up a community, and between whom an infection would be spread. when: a central premise of the dssw-abm is that agents are primarily creatures of habit, operating on routine schedules with slight random perturbations [16]. what: the factor of interest is the spread of the ph1n1 virus or other viruses that cause respiratory infections among the population of agents, through agent-to-agent contact associated with routine daily activities. once infected, the agents probabilistically choose to stay home for the duration of the infection or attend a hospital ed. as an intervention, we have considered modeling the potential role of ‘crowdinforming’ in directing or governing an agent’s behaviour. the notion of ‘crowdinforming’ is a natural extension of ‘crowdsourcing’ [16], whereby data collected by crowdsourcing is again fed back to the ‘crowd’ via public access. low-tech examples of the role of ‘crowdinforming’ in modifying human behaviour are readily available, such as line-ups at vaccination clinics as vaccine shortages are announced in the mass media. while a fairly obvious intervention, ‘crowdinforming’ is a novel inclusion into the abm and simulation. methods the abm engine is coded in c++, an object oriented language. the object oriented approach has natural extensions to the spatial modeling inherent in the spatial nature of the system under study. developing an abm within an object oriented framework from the ground up provides an additional degree of understanding the problem in contrast to using a more commercial platform. the simulated world is a two-dimensional (x, y) discrete cartesian world of extremely high resolution. building upon the proof-of-concept, the abm is general purpose and at present is a spatially directed abm reflective of a specific topography – in this case, the city of winnipeg, canada. agents can access a limited number of features of other agents and objects, which can be set by the programmer, depending on the model. they can also pass messages to other agents in order to achieve interaction. the abm houses institutions such as hospitals, homes, malls, leisure facilities, schools, businesses, and transportation institutions such as cars and public transport. graphical inputs serve as defining location derived from maps and community planning documents. the abm framework is illustrated in fig. 1. the publicly accessible information ‘dashboard’ is illustrated on the left-hand side, providing near real time information on waiting times at various eds at hospitals within a region. currently, this information is available in individual facilities’ waiting rooms; yet, for the present simulation it is assumed to be web accessible to the general public via readily available web services. the web services can include traditional web 2.0 applications supporting dynamic updating of web pages based on new information from various facility waiting time estimates, as well as access via traditional wired services to those offered over 3g cellular networks or ‘smart phones’. agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 fig. 1. the abm framework encompassing various data sources. a. modeling surges at hospitals this section outlines the urban based abm under conditions associated with an ili outbreak in winnipeg, canada. in the model, a parameterized distribution of households is associated with a colour as a graphical input. for this scenario, various colours represent a number of multiple person households uniformly distributed across winnipeg, as shown in fig. 2. at this scale, the colours tend to blend although roads, rivers, and other infrastructure and features are clearly evident. fig. 2. a screenshot of the abm input. a number of institutions such as schools, large businesses, restaurants, leisure institutes as well as hospitals are modelled. the spread of infection is a stochastic process with the probability of infection being directly related to social contact. social contact can take place at home, work, school, or on public transport, with institutions also having probabilities of contraction associated with them. a baseline simulation involves scheduled agents being modelled, and as they become ill, they probabilistically go to the closest ed. once at the ed, another individual-based state or phase model is introduced as illustrated in fig. 3. at the ed, the agent may be discharged, agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 treated, or admitted. once admitted, the patient may again undergo treatment and recover, or alternatively the agent may not recover. the current institutional ed model is quite simple but could be extended and refined with a more detailed model as required, an example of which has been developed by the authors [18][19]. fig. 3. the emergency department individual based model. a statistic instrumented during the simulation was the number of agents arriving at individual hospital eds. these surges are shown in fig. 4 for the seven hospitals in the winnipeg area. fig. 4. simulated surges at winnipeg hospitals during an outbreak agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 fig. 5. day of week variations at winnipeg hospitals during an outbreak fig. 4 illustrates a disparity between various hospitals, corresponding to population density variations with the city. fig. 5 illustrates the variation within weekly routines or schedules. these data are averaged over five runs. this averaging raises an interesting consideration from a policy perspective: as the data is averaged, it tends to become smoother and may tends to mask shortterm variations that may otherwise be present and important to note in the physical environment as well as the model. results: self redirection b. ‘crowdinfoming’ diversions although expected, reduced surges at hospital eds can reasonably be argued to facilitate improved treatment and service efficiencies during an outbreak. these outcomes illuminated a potential indirect intervention. the modelling initially planned for reactive hospital diversions, i.e. setting demarcation levels related to capacity to support diversion policy and redirection [20]. with recent interests in ‘crowdsourcing’ [16] and as a means to aid in biosurveillance of potential infection spread, the model was adapted to model the counterpoint of ‘crowdsourcing’, that being ‘crowdinforming.’ one of the fundamental tenets of ‘crowdsourcing’ is that the feedback loop needs to be closed, as information mined through crowdsourcing flows back to the crowd that generated it, presumably to accrue benefit. at present, one trial hospital in the winnipeg regional health authority (wrha) jurisdiction has an ed ‘dashboard’ in place, updating the number of patients waiting and their waiting times in terms of maximum wait at various triage levels. the dashboard is intended to inform those already in the waiting room of the anticipated wait before being seen. these dashboards are derived from the wrha electronic data information system (edis) which was recently rolled out across the wrha hospitals. our model develops this notion further and conjectures that in a reasonably short period of time, this data could be made publicly available through a web service, such that an individual would be able to query the hospital ‘dashboards’ from the wrha site over the internet with any browser, be it mobile cellular or wired, or made available agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 via a community call centre such as a 311 service whereby a patient would call and enquire about expected wait times. for our modeling purposes, in this ‘crowdinforming’ scenario, a proactive decision is then made by an agent seeking treatment at an ed. in addition to the stochastic process of deciding upon going to an ed, each agent is also provided with estimates of wait times and the number of patients waiting. this data is available and easily instrumented within the abm. as an illustration of our weighted fair redirecting, we assumed four hospitals with waits of 1, 2, 3 and 4 hours with travel times of 60 minutes, 45 minutes, 30 minutes, and 15 minutes, coarsely extracted from topographical distances. an agent would create a roulette wheel to guide their decision once they have elected to go to an ed. the associated normalized probabilities associated with informed self redirection are shown in table 1. table 1. informed emergency department self redirect probabilities ed 1 ed 2 ed3 ed4 tot al wait time (hr) 1 2 3 4 travel time (hr) 1 0.75 0.5 0.25 total time (hr) 2 2.75 3.5 4.25 12.5 1/over ½ 1/2. 75 1/3. 5 1/4. 25 1.38 probabili ty 0.36 0.26 4 0.20 7 0.17 1.0 table 1 combines estimates of travel time and wait times in an additive manner. alternatively, it may be more appropriate to generate a total time as a linear combination weighted appropriately as in (1). (1) using such a method, the agents make a probabilistic decision weighted by the least anticipated wait. as a consequence, the overall surge seen at hospitals is dampened by the behaviour of informed individuals. modeling the ‘crowdinformed’ load-balancing results in surges at hospital as shown in fig. agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 fig. 6. surges at winnipeg hospitals with ‘crowdinforming’. crowdinforming appears to filter the simulated patient surges. a simple statistical measure associated with mean and variance indicates that the load balancing is statistically significant given our behavioural assumptions, where a known estimated wait time probabilistically influences a person’s decision in attending a particular ed. the overall effect was expected to be that of a low pass filter smoothing out the peaks and valleys in both space and time. fig. 6 clearly illustrates filtering in space as each ed roughly serves the same number of patients within a few percent. filtering in time is expected to result from incorporation of an estimate of travel time as indicated in equation 1. this simulation illustrates load balancing at the cost of greater variance in the patient load over time. this type of emergent behaviour inherently has greater information content than anticipated or expected results. while the simulation results are presently a coarse approximation of a policy implementation, they serve as an indication of possible trends and side effects. as a further extension, the additions of temporary clinics were also modeled. the temporary clinics were modeled as being available provided sufficient staff resources existed to off-load eds during a serious influenza outbreak. in this case, hospitals were augmented with temporary clinics and the public was informed of their location and services. temporary clinics are modelled as being staffed with and providing a level of service similar to a hospital ed. in the following simulation, six temporary facilities were instantiated in highly populated postal code areas. given the model of the information provided to the public, the consequent balancing of loads at hospital eds and temporary clinics are seen to be balanced. fig. 7 also demonstrates the effect of prioritizing travel in the decision-making process (fig. , with 80% of infected agents seeking treatment. in addition, acute patients are modeled as not presenting themselves at a clinic but rather deciding to directly attend an ed. an additional modification is that the temporary clinics are more heavily recommended once hospitals near capacity, or alternately that hospitals are preferred destinations until they are near capacity. agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 fig. 7. surges at winnipeg hospitals and clinics with ‘crowdinforming’. an additional parameter of interest was the location of temporary clinics. for the simulation above, the clinics were located in central and highly populated postal code areas. the simulation allows for one to vary the location of clinics, such that they may better serve a community or region. fig. 8 illustrates a simulation run without averaging over multiple runs (which carries the effect of averaging over multiple days). without averaging, the day to day variations are clearly apparent. if this variability were to be an actual consequence of the patient self redirection policy, it may be that the increase in day to day variation would not be a reasonable trade-off for a balanced load. it is these types of insights that abm and what-if scenarios provide for policy makers a-priori to policy implementation. fig. 8. hospital loads without averaging. agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 discussion although preliminary, this work represents one of the first modelled instances of the potential of ‘crowdinforming’ in providing a policymaker with a simulation to assist in public health decision support. in doing so, this work illustrated the role that an abm can play in developing policy decision support systems. the model presented here illustrates how one specific intervention – that of proactive information dissemination or ‘crowdinforming’ – can provide a degree of patient load balancing at eds. a similar model was constructed corresponding to the scenario where sufficient public health resources existed for the deployment of temporary clinics. in the event of the temporary clinics, the model also allows for an investigation into their utilization where the public would be informed of their location and services. the findings are somewhat self-evident in that the model for ‘crowdinforming’ contributed to load balancing at individual hospital eds. the findings also indicate that the location of the clinics is reasonably important in off-loading eds. the most significant limitations associated with research of this nature is that stochastic models of behaviour have to be estimated. other shortcomings are associated with the access and usability of real data. these latter barriers are technological, while the former are theoretical. the validity of the underlying abm framework is enhanced as the characterization of agents and their behaviours is improved and refined with additional real data. consequently, barriers to access and usability of real data – whether technological or political – are limitations to the work. a more significant deficit in the model is that the deployment of temporary clinics assumes that the resources exist for staffing and treatment. summary the work presented here allows a policy for patient directed redirection to be simulated, adding a qualitative assessment to a model that may otherwise be experiential or best-intent. this work is one of the first demonstrations of the ‘crowdsourcing’ intervention, and it demonstrates the role an abm and similar technologies will continue to play in the future. . acknowledgments the authors acknowledge maciej borkowski, marek laskowski, and bryan demianyk for early developments of the abm framework. the authors also acknowledge manitoba hydro for financial support. correspondence: bob mcleod university of manitoba mcleod@ee.umanitoba.ca agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 references [1] marshall a, burns l. a bayesian network hybrid model for representing accident and emergency waiting times. proceedings of the ieee symposium on computer-based medical systems. june 2007; 91-96. [2] komashie a, mousavi a. modeling emergency departments using discrete event simulation techniques. proceedings of the winter simulation conference. dec. 2005; 2681-2685. [3] patrick j, puterman m. reducing wait times through operations research: optimizing the use of surge capacity. healthcare quarterly, 2008;11(3): 77-83. [4] khurma n, bacioiu g, pasek z. simulation-based verification of lean improvement for emergency room process. proceedings of the winter simulation conference. dec 2008;14901499. [5] mcnulty t, re-engineering health care: the complexities of organizational transformation, new york, oxford university press, 2002. [6] kanagarajah a, lindsay p, miller a, parker d. an exploration into the uses of agent-based modeling to improve quality of health care. international conference on complex systems. june 2006; 1-10. [7] gunal m, pidd m. simulation modelling for performance measurement in healthcare. proceedings of the winter simulation conference, dec. 2005; 2663 2668. [8] blachowicz d, christiansen j, ranginani a, simunich k. how to determine future her roi: agent-based modeling and simulation offers a new alternative to traditional techniques, j. healthcare information management. winter 2008;22(1):39-45. [9] gunal m, pidd m. understanding accident and emergency department performance using simulation. proceedings of the 38 th conference on winter simulation, 2006;446-452. [10] bonabeau e. agent-based modeling: methods and techniques for simulating human systems. proceedings of the national academy of science. may 2002 [online]. 99(suppl 3), pp. 7280-7287. available: http://www.pnas.org/content/99/suppl.3/7280.full#xref-ref-31 [11] epstein j. modelling to contain pandemics. nature. 2009:460;687. [12] hupert n, xiong w, mushlin a. the virtue of virtuality: the promise of agent-based epidemic modeling,” translational research. 2008:151(6):273-274. [13] epstein j. artificial society: getting clues on how a pandemic might happen by creating a huge model of the united states, the brookings institution. [online]. available: www.brookings.edu/interviews/2008/0402_agent_based_epstein.aspx. [14] merler s, ajelli m, jurman g, furlanello c, rizzo c., bella a, massari m, ciofi degli atti m. modeling influenza pandemic in italy: an individual-based approach. the 2007 intermediate conference of the italian statistical society. june 2007. available http://www.sis-statistica.it/files/pdf/atti/sis%202007%20venezia%20intermedio_121131.pdf [15] m. borkowski m, podaima b, mcleod r., epidemic modeling with discrete space scheduled walkers: possible extensions to hiv/aids,” bmc public health, vol. 9 (suppl 1): s14, 2009. [online}. available: doi:10.1186/1471-2458-9-s1-s14. [16] song, c, qu z, blumm n, barabási a. limits of predictability in human mobility, science, 2010 327(5968);1018-1021. agent based modeling of “crowdinforming” as a means of load balancing at emergency departments 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 [17] howe j, the rise of crowdsourcing. wired. june 2006, http://www.wired.com/wired/archive/14.06/crowds.html. [18] laskowski m, borkowski m, demianyk b, friesen m, mcleod r. the utility of agentbased models for healthcare applications,” the second iasted international conference on telehealth and assistive technology, cambridge, ma, nov. 2009. [19] laskowski m, mcleod r,friesen m, podaima b, alfa a., models of emergency departments for reducing patient waiting times. plos one,. 2009;4(70: e6127. [online]. available: doi:10.1371/journal.pone.0006127, 2009. [20] mukhi s, laskowski m, agent-based simulation of emergency departments with patient diversion. electronic healthcare, d. weerasinghe, ed. berlin: springer. 2009;25-37. paper details an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 an agent based model for simulating the spread of sexually transmitted infections grant rutherford 1 , marcia r friesen 1 , robert d mcleod 1 1 electrical & computer engineering, university of manitoba, canada abstract this work uses agent-based modelling (abm) to simulate sexually transmitted infection (stis) spread within a population of 1000 agents over a 10-year period, as a preliminary investigation of the suitability of abm methodology to simulate sti spread. the work contrasts compartmentalized mathematical models that fail to account for individual agents, and abms commonly applied to simulate the spread of respiratory infections. the model was developed in c++ using the boost 1.47.0 libraries for the normal distribution and opengl for visualization. sixteen agent parameters interact individually and in combination to govern agent profiles and behaviours relative to infection probabilities. the simulation results provide qualitative comparisons of sti mitigation strategies, including the impact of condom use, promiscuity, the form of the friend network, and mandatory sti testing. individual and population-wide impacts were explored, with individual risk being impacted much more dramatically by population-level behaviour changes as compared to individual behaviour changes. keywords: agent based modelling, modelling and simulation, sexually transmitted diseases, social networks introduction the objective of this work was to develop an agent-based model (abm) to simulate the spread of sexually transmitted infections (stis) within a population of interacting agents. as a preliminary application of the abm methodology to sti spread, the focus of this work was to explore the inherent suitability and potential of the abm method to this particular context. agent based modelling is becoming an effective tool in understanding infection spread and is particularly well suited to environments where the agents themselves and their interaction with one another are the principal vectors of infection spread. agent-based models have emerged in the past decades as a complementary approach to the long history of differential equation-based models that require a macroscopic perspective of the population of interest [ 1]. agent based modelling is ‘bottom-up’ systems modelling from the perspective of constituent parts. systems are modelled as a collection of agents (in this case, people) imbued with properties: characteristics, behaviours (actions), and interactions that attempt to capture actual properties of individuals. in the most general context, agents are both adaptive as well as autonomous decision-making entities who are able to assess their situation, make decisions, compete with one another on the basis of a set of rules, and adapt future behaviours on the basis of past interactions. agent properties may be conceived by the modeller or may be derived from actual data that reasonably describe agents’ behaviours – i.e. their http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 movements and their interactions with other agents. the modeller’s task is to determine which data sources best govern agent profiles in a given abm simulation [ 2] ,[ 3]. the foundational premise and conceptual depth of abm is that simple rules of individual behaviour will aggregate to illuminate or exhibit complex and emergent group-level phenomena that is not specifically encoded by the modeller [ 3] ,[ 3]. this emergent behaviour may be counterintuitive or a complex behavioural whole that is greater than the sum of its parts. furthermore, abm provides a natural description of a system that can be calibrated and validated by subject matter experts, and is flexible enough to be tuned to high degrees of sensitivity in agent behaviours and interactions. abms are considered particularly applicable to situations where interactions are local and potentially complex, where agents are heterogeneous, where the phenomenon has inherent temporal aspects, and where agents are adaptive [ 2][ 5]. much of the work in abm to date has focussed on the simulation of contact-based infection spread associated with influenza-like illnesses and other respiratory infections, including coarse-scale community, country, and global models [ 6][ 13] to finer-scale community and institutional models [ 14] ,[ 15]. increasingly, there are considerable data that can be used to improve the fidelity of an abm in representing real social networks in ways that are highly amenable to understanding the type of contacts (casual and behaviour-agnostic) that facilitate infection spread. these data may be generated for other purposes but are increasingly available toward secondary and tertiary applications within an emerging ‘data culture’. these data that can be mined and analysed to generate agent contact and movement patterns include, for example, intelligent transportation systems (vehicular, public, air travel, etc), cellular service provider data, and a range of location-based services and technologies that may leverage smartphones and other bluetooth-enabled mobile devices. additionally, there is a large body of literature on modelling sexually transmitted infection spread based on equation-based monolithic approaches or compartmental mathematical models [ 15] ,[ 16] ,[ 17]. monolithic analytical models use one governing equation to model the population, while compartmental tools reduce the population to a few key characteristics which are relevant to the infection under consideration. these models are limited to treating simplified scenarios and are not amenable to including data directly pertaining to each individual agent. in contrast, the strength of abm lies in its detailed and naturalistic representation of agents and scenarios and the ability to directly integrate real data. however, modelling of sexually transmitted infections presents a more significant challenge to abms than modelling of contact-based respiratory infections. proximate contact and geographical location (important factors in respiratory infection spread) are a minor factor in sti transmission, while agent behaviour becomes a defining parameter, including the formation of relationships, and an agent’s network of contacts through which relationships may be established. in addition the topic of sexually transmitted infections and sexual behaviour is a sensitive topic for most people, and accurate and full disclosure of activities in order to accurately characterize agents in the model is difficult to achieve. this work derives novelty in applying the abm methodology to the context of sti spread, which has traditionally been modelled by equation-based and compartmental methods. at the early stage of applying abm methods to the simulation of sti spread, qualitative comparison to general known outcomes is a meaningful objective. overall, the usefulness of abm validation by qualitative comparison to known outcomes has been established by others [ 1]. http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 there are known limitations stated at the end of the paper, and these limitations would need to be addressed thoroughly before reliable results could be extracted from the simulation. at this stage of the work, the focus is on exploring the potential and suitability of the abm method to this context. drawing on these findings, future work will refine the abm and then emphasize and analyse the results of the simulations themselves in detail. methods the agent based model this work developed an agent-based model to simulate the spread of sexually transmitted infections, or stis, which are difficult to study directly. the study created an abm of a population of sexually active people. a disease is introduced to this population from the external world, and its progress can be traced through the model. this approach allows the effects of various mitigative and control policies and behaviours to be easily analyzed. the use of a computer model allows thousands of populations to be tested in a short amount of time, so the possible effects of new policies and behaviours can be evaluated quickly and easily. within the model, each agent has both predetermined and fixed parameters which regulate their behaviour. each agent can also be in a number of different states which affect the expression of their predetermined parameters. the movement of agents from a healthy state to an infected state simulates the spread of a sexually transmitted infection through the population. each simulation was run with a population of 1000 people for a period of 10 simulated years (3652 days) after the initial infection. these output included the proportion of the population which was infected, and records of the individuals along with their final infection state and the number of people to whom they passed the infection. in all cases, the original source of the infection is the “outside world”, and the infection enters the population through sexual contact between the population and the outside world. the process of simulating a population involves two major steps. the population is generated and a period of one year is simulated without any chance of infection in order for the proportion of monogamous relationships to become stable. following this initial calibration step, the simulation runs for exactly 10 years after the first agent in the population is infected. each simulation is repeated approximately 5000 times with a new population generated each time. results are accumulated and averaged to show the trends in the data. the abm framework was coded in c++ using the boost 1.47.0 libraries for the normal distribution and opengl for visualization. model setup the first step of simulation is the generation of the agent population. each individual agent in the simulation is randomly assigned unique values which will govern their behaviour. these values are assigned from a distribution which is characterized by global mean and standard deviation parameters. these global distribution parameters define the mean and variance of a parameter in a population, but each individual agent is assigned a specific and fixed value for each parameter upon generation, so that their profile is unique in relation to other agents in the simulation. standard parameter values for the distributions are given in table 1. http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 for both the baseline simulation scenario and to explore various intervention scenarios, the simulation is run multiple times from same initial model conditions in order to average the results. the population of agents is regenerated for each simulation run, so that the agents are different each time, but the distributions from which their parameter values are drawn are constant for a given scenario. more specifically, each agent is randomly assigned to be male or female. following this, each person is assigned a unique value for each of 15 unique parameters, which vary with a restricted normal distribution between 0 and 1 (table 1). each of these 15 parameters represents a probability, or an offset to a probability. a 16 th parameter, “desiredfriends” is an integer and is determined by taking the floor of a normally distributed value with a mean of 2 and a standard deviation of 2, and re-rolling the value if it falls below 1. in this manner everyone has at least one friend. where possible, parameter values were informed by the body of literature on the topic [ 18] ,[ 19]. friendship model the “friendship” model simulates connections between people. these connections may be interpreted as frequent contact: a close friend, a co-worker, etc. during the simulation, these links and networks will often be used to find partners for relationships and for sex. realistically, a person would be expected to have many such connections, but this model only included the most relevant. for the sake of clarity, from now on these connections will be referred to as friends. the “cliquefactor” parameter has the ability to control the separation of people into tight groups of friends (high cliquefactor) or a more connected but randomly shaped network (low cliquefactor). a cliquefactor of 0.7 was chosen as the standard value for the model, which gives a well-connected network with tight clusters of friends. the network evolves over time as relationships instantiated and later dissolve, while maintaining a small world flavour. http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 table 1: population parameters with standard values parameter type mean std. dev. description ismale 50/50 na na male or female basesexavailability (bsa) re-roll m = 0.5 f = 0.03 m = 0.2 f = 0.05 base chance of availability for sex outside of monogamy basesexseeking (bss) restricted m = 0.1 f = 0.002 m = 0.1 f = 0.002 base chance to be seeking sex if also available, outside of monogamy basecondomuse (bcu) restricted 0.9 0.5 base chance of desiring a condom availablemonogamy re-roll 0.08 0.04 chance of being available for a new mono. relationship seekingmonogamy re-roll 0 0.01 chance of seeking a new monogamous relationship exitmonogamy re-roll 0 0.001 chance of terminating an existing mono. relationship monogamoussexrate re-roll 0.15 0.1 chance of desiring sex during monogamy monosexavailabilitydecrease dependent 1 x bsa 0.4 x bsa offset to bsa while monogamous monosexseekingdecrease dependent 1 x bss 0.3 x bss offset to bss while monogamous monocondomdecrease restricted 0.5 0.5 offset to bcu while monogamous diseaseavailabilitydecrease dependent 1.2 x bsa 0.8 x bsa offset to bsa while diseased diseaseseekingdecrease dependent 1.5 x bss 0.5 x bss offset to bss while diseased diseasecondomincrease restricted 0.8 0.5 offset to bcu while diseased testinghealthy restricted -0.1 0.05 daily chance of getting tested while healthy testingsymptoms restricted 0.1 0.1 daily chance of getting tested while symptomatic desiredfriends special 2 2 desired number of friends simulation the simulation of the infection spread through the population happens in discrete units of time, chosen to be one day per step. during each simulated day, the following steps are done in order. the simulation continues for 3652 days (10 years) after the first agent is infected. while the model is running there are a number of relationship changes that can occur. these include: step 1 monogamy changes: in this step, a list of people in monogamous relationships is generated, along with probabilities of relationships ending, new relationships desired, and new monogamous relationships formed within the population. when new relationships form, there is a 95% chance that a person will choose someone from within their friend network, and a 5% chance that a person will choose someone at random from the list of available people. finding someone through the friend network uses a breadth-first search of up to 5 hops, with the closest available person of the opposite gender selected. if more than http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 one person is found at the same distance, then one is selected at random. if no suitable person is found using the friend network, then the seeker will default to selecting someone at random from the list of available people of the opposite gender. the above process is repeated until either the seeking list is depleted, or the list of available people is depleted of either gender. at this point, monogamous relationship matching is completed. step 2 – determining sexual encounters: monogamous sexual encounters: each person in a monogamous relationship uses their monogamoussexrate variable in order to determine if they desire monogamous sex. this value is first modified by subtracting their diseaseavailabilitydecrease parameter if they are confirmed to have the infection. if they are symptomatic for the infection, but have not been tested, then they subtract half of the value of this parameter. if the resulting value is less than zero, then a zero probability is used. non-monogamous sexual encounters: this is a complex parameter impacted by sex availability and modulated by the agent’s non or symptomatic state, but following the general process of matching people into monogamous relationships. “cheating” within monogamous relationships is also accounted for. step 3 spreading the infection: while the model is running there are a number of factors that impact the spread of infection, including the basecondomuse parameter modified by their monogamy status and their infection status (including varying probabilities for symptomatic but unconfirmed, vs. tested and confirmed). once condom use has been determined, each encounter between a person who is uninfected and a person with the infection has a probability of infection transmission (modified by condom use) and a subsequent probability of becoming symptomatic if infected. becoming symptomatic further impacts probability of testing and probability of behaviour modification. step 4 testing for infection: the final step in the simulated day is to test members of the population for the disease, accounting for persons (asymptomatic) who may submit to a spontaneous test, and the probability of symptomatic persons seeking testing. results and discussion when evaluating the simulation, the metric used was the infected proportion of the population after 10 years. ten years was chosen in order to capture an average infection prevalence of around 50%, which allows ample room to both evaluate changes in outcomes through parameter changes. with the standard parameter values, the average infection prevalence after 10 years was 48.71% over 4732 trials. two types of analysis were performed on the model. the first set involved 4732 trials (simulations) using the standard parameters, and collecting data on the 4,732,000 simulated agents (1000 agents x 4732 trials) generated for these trials. by measuring correlations between agent parameters and infection outcomes, some trends regarding individual risk can be identified. the second type of analysis involved using the standard parameter values for all parameters but one, and varying a single parameter through a range of values. these trials http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 can be used to investigate the results of general policy or behaviour changes applied to the entire population. individual risk: condom use: the most pronounced impacts related to condom use. condom use while healthy and single was strongly related to an individual's risk of acquiring an infection (fig. 1). condom use while single and aware of being infected is strongly correlated to the likelihood of passing the infection to others (fig. 2). figure 1: individual risk vs. condom use (healthy & single) figure 2: infection spread to others vs. condom use (infected & single) http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 sexual availability was correlated with individual risk of acquiring an infection. however, the risk of infection remains near 25% even for persons who are never available for sex, due to the possibility of acquiring infection through partners in monogamous relationships (accounting for a degree of ‘cheating’). the risk of infection was only moderately affected by an agent’s average number of friends, with nine friends corresponding to an infection risk of 55.2% and having one friend corresponding to an infection risk of 46.5%. since a large proportion of seeking occurs through the friend network, the proximity of a person to potential partners through the friend network will impact frequency of interaction. population data: in comparison with the individual data in the previous section, the population data was obtained by changing the standard model parameters, one by one, thereby of changing the properties and behaviour of the entire population. four parameters were varied: condom use, promiscuity, time between mandatory testing, and cliquey-ness of the friend network. in total, 60 discrete values of each of the four noted parameters parameter were tested, and the simulation results were averaged over 50 repeated simulation runs at each value. condom use: global changes to condom use have a very significant effect on the disease prevalence (fig. 3), with an infection prevalence of 97.4% and 13.9% with mean condom use of 0 and 1, respectively. dramatic changes to condom have the potential to reduce the infection prevalence by more than a factor of 7. figure 3 shows a steep change in infection prevalence at a mean condom use between 60% and 80%, suggesting a threshold over which the ubiquitous use of condoms severely slows the spread of infection. beyond this level, the benefits from higher condom attenuate. figure 3: infection prevalence vs. population condom use http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 promiscuity: the impact of promiscuity was simulated by controlling availability for sex and sex-seeking characteristics. population infection prevalence ranged from 48.7%, 13.6% and 88.2% with promiscuity parameters at standard, halved, and doubled values, respectively. mandatory infection testing: this parameter varied the length between mandatory infection testing of all individuals (including healthy, asymptomatic) from daily testing to testing every 14.7 years, in increments of 91 days. the infection prevalence decreased steadily as the test interval decreased. annual testing resulted in population infection prevalence of 15.3%. with testing at 14.7 year intervals, the population infection prevalence dropped from 48.7% (the standard model) to 43.0%. even in the impractical scenario of daily mandatory testing, an endemic level of infection remains in the population. friend network: the impact of the form of the friend network was examined by altering the connectedness of the network. the results showed no meaningful correlation between the form of the friend network and infection prevalence within the population. conclusion there are some known limitations to this agent-based model for sti spread. while the 16 parameters act both independently and in combination and represent numerous complex combinations and many unique agent profiles, they nonetheless do not capture the full range of agent profiles, agent behaviours, and infection transmission dynamics within a population. for example, this model only considers opposite-sex sexual encounters. second, in this simulation, agents never leave the population and new agents do not enter the population. agents remain in state and are immortal, representing a simplification of real movement of people into and out of networks. furthermore, in this model, the agent behavioural probabilities (seeking, condom use, etc.) remain the same, regardless of whether the overall infection prevalence within the population is low or high. in reality, some behaviour modification is initiated when infection prevalence rises due to personal knowledge of risk and public health messages. population norming becomes a feedback mechanism (e.g. public health messages toward hand hygiene and cough etiquette during pandemic influenza). in this model, a sexual encounter is equated with an infection transmission with some probability (determined by interacting agent parameters). in reality, the mapping of the sexual encounter to infection transmission is more complex, as disease epidemiology needs to be taken into account. it is known, for example, that the rate of transmission may be dependent on the stage of a disease, which is not accounted for in the current model. notwithstanding the limitations, the qualitative results of the model correspond well with known priorities in sti mitigation strategies. this finding supports the objective of determining the potential and suitability of the abm methodology to the context of sti spread, and an sti-abm’s future potential as a tool in public health decision-making and policy. a person can significantly control their individual infection risk by using a condom and avoiding non-monogamous sex. this result is intuitive and supported by simulation. however, individual risk is not reduced as easily or dramatically through individual behaviour modification as it is through collective behavioural changes in the population which reduces collective risk. this mirrors the impact of vaccination for childhood diseases, where protection is only achieved through population-wide compliance. this result is also intuitive, considering the cascading effects within a network, where collective behaviour changes are amplified because individuals benefit from the changes to their own behaviour and also from the reduction in risk due to the change in behaviour of their peers. this makes http://ojphi.org/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 a strong case for public health policy promoting sexual health, such as the promotion of condom use and responsible sexual behaviour. mandatory testing for stis can have a very strong effect in limiting their spread. challenges including the lack of incentive for testing particularly if asymptomatic, the personal disincentives (e.g. potential embarrassment), and the stigma attached to stis. this work has presented an agent-based modelling framework for the simulation of sexually transmitted infection spread within a population of 1000 people, over a 10-year period, in order to explore the applicability of the abm approach to sti modelling. while these results provide some preliminary support for the suitability of the abm methodology to an sti application, all of these results need to be more robustly explored and verified by developing the abm further to address the stated limitations. in general, the methodology is well suited to practitioners and educators, and lends itself to qualitative assessments of various mitigation and control measures related to sti spread. there is considerable refinement that may be easily undertaken as the abm methodology explicitly facilitates dialog within an easily communicated lexicon. an accompanying youtube video illustrating the model and evolving network can be found at http://www.youtube.com/watch?v=aql8mbgns8u funding this research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. conflicts of interests none. corresponding author marcia friesen assistant professor, design engineering university of manitoba, canada email: marcia.friesen@ad.umanitoba.ca references 1. emrich s, suslov v, judex f. fully agent based modelling of epidemic spread using anylogic. proc. eurosim 2007, 9-13 sept. 2007, ljubljana, slovenia. 2. bonabeau e. 2002. agent-based modelling: methods and techniques for simulating human systems. proc natl acad sci usa. 99(suppl 3), 7280-87. http://www.pnas.org/content/99/ suppl.3/7280.full#xref-ref-3-1. http://dx.doi.org/10.1073/pnas.082080899 3. rand w, rust rt. agent-based modelling in marketing: guidelines for rigor. international journal of research in marketing 2011, http://ijrm.feb.uvt.nl/uploads/ forthcoming_d-10-00071_randrust.pdf http://ojphi.org/ http://www.pnas.org/content/99/suppl.3/7280.full#xref-ref-3-1 http://ijrm.feb.uvt.nl/uploads/forthcoming_d-10-00071_randrust.pdf http://www.youtube.com/watch?v=aql8mbgns8u mailto:marcia.friesen@ad.umanitoba.ca http://www.pnas.org/content/99/ http://dx.doi.org/10.1073/pnas.082080899 http://ijrm.feb.uvt.nl/uploads/ an agent based model for simulating the spread of sexually transmitted infections online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 3, 2012 4. goldstone rl, janssen ma. 2005. computational models of collective behaviour. trends cogn sci. 9, 424-30. http://dx.doi.org/10.1016/j.tics.2005.07.009 5. hupert n, xiong w, mushlin a. 2008. the virtue of virtuality: the promise of agent-based epidemic modeling. transl res. 151(6), 273-74. http://dx.doi.org/10.1016/j.trsl.2008.04.002 6. epstein jm. 2009. modelling to contain pandemics. nature. 460, 687. http:// dx.doi.org/10.1038/460687a 7. germann tc, kadau k, longini im, jr, et al. 2006. mitigation strategies for pandemic influenza in the united states. proc natl acad sci usa. 103, 5935-40. http:// dx.doi.org/10.1073/pnas.0601266103 8. longini im, jr, nizam a, xu s, et al. 2005. containing pandemic influenza at the source. science. 309, 1083-87. http://dx.doi.org/10.1126/science.1115717 9. ferguson nm, cummings dat, fraser c, et al. 2006. strategies for mitigating an influenza pandemic. nature. 442, 448-52. http://dx.doi.org/10.1038/nature04795 10. bobashev gv, goedecke dm, yu f, et al. a hybrid epidemic model: combining the advantages of agent-based and equation-based approaches. proceedings of the 2007 winter simulation conference 2007;1532-1537 11. merler s, ajelli m, jurman g, et al. modeling influenza pandemic in italy: an individualbased approach. proceedings of the 2007 intermediate conference of the italian statistical society 2007, http://www.sisstatistica. it/files/pdf/atti/sis%202007%20venezia% 20intermedio_121-131.pdf 12. skvortsov bat, connell rb, dawson pd, et al. epidemic modelling: validation of agentbased simulation by using simple mathematical models. modsim 2007 international congress on modelling and simulation. modelling and simulation society of australia and new zealand 2007; 657-662. 13. borkowski m, podaima bw, mcleod rd. 2009. epidemic modeling with discrete space scheduled walkers: possible extensions to hiv/aids. bmc public health. 9(suppl 1), s14. http://dx.doi.org/10.1186/1471-2458-9-s1-s14 14. meng y, davies r, hardy k, et al. 2010. an application of agent-based simulation to the management of hospital-acquired infection. journal of simulation. 4, 60-67. http:// dx.doi.org/10.1057/jos.2009.17 15. mukhi s, laskowski m. agent-based simulation of emergency departments with patient diversion. in electronic healthcare, d. weerasinghe, ed. berlin: springer, 2009:25-37. 16. anderson rm, geoffrey g. 2000. mathematical models of the transmission and control of sexually transmitted diseases. sex transm dis. 27, 636-43. http:// dx.doi.org/10.1097/00007435-200011000-00012 17. ferguson nm, geoffrey gp. 2000. more realistic models of sexually transmitted disease transmission dynamics: sexual partnership networks, pair models, and moment closure. sex transm dis. 27, 600-09. http://dx.doi.org/10.1097/00007435-200011000-00008 18. doherty ia, shiboski s, ellen j, et al. 2006. sexual bridging socially and over time: a simulation model exploring the relative effects of mixing and concurrency on viral sexually transmitted infection transmission. sex transm dis. 33, 368-73. http:// dx.doi.org/10.1097/01.olq.0000194586.66409.7a 19. azra gc, geoffrey gp. 2000. risks of acquiring and transmitting sexually transmitted diseases in sexual partner networks. sex transm dis. 27, 587-97. 20. new york city department of health and mental hygiene. community health survey 2011, http://www.nyc.gov/html/doh/html/survey/survey.shtml, accessed october 19, 2012. http://ojphi.org/ http://www.sis-statistica.it/files/pdf/atti/sis%202007%20venezia%20intermedio_121-131.pdf http://www.sis-statistica.it/files/pdf/atti/sis%202007%20venezia%20intermedio_121-131.pdf http://www.nyc.gov/html/doh/html/survey/survey.shtml http://dx.doi.org/10.101%ed%af%80%ed%b0%99/j.tics.200%ed%af%80%ed%b0%98.07.009 http://dx.doi.org/10.101%ed%af%80%ed%b0%99/j.trsl.2008.0%ed%af%80%ed%b0%97.002 http://dx.doi.org/10.1038/%ed%af%80%ed%b0%97%ed%af%80%ed%b0%990%ed%af%80%ed%b0%9987a http://dx.doi.org/10.1038/%ed%af%80%ed%b0%97%ed%af%80%ed%b0%990%ed%af%80%ed%b0%9987a http://dx.doi.org/10.1073/pnas.0%ed%af%80%ed%b0%99012%ed%af%80%ed%b0%99%ed%af%80%ed%b0%99103 http://dx.doi.org/10.1073/pnas.0%ed%af%80%ed%b0%99012%ed%af%80%ed%b0%99%ed%af%80%ed%b0%99103 http://dx.doi.org/10.112%ed%af%80%ed%b0%99/science.111%ed%af%80%ed%b0%98717 http://dx.doi.org/10.1038/nature0%ed%af%80%ed%b0%9779%ed%af%80%ed%b0%98 http://www.sisstatistica http://dx.doi.org/10.118%ed%af%80%ed%b0%99/1%ed%af%80%ed%b0%9771-2%ed%af%80%ed%b0%97%ed%af%80%ed%b0%988-9-s1-s1%ed%af%80%ed%b0%97 http://dx.doi.org/10.10%ed%af%80%ed%b0%987/jos.2009.17 http://dx.doi.org/10.10%ed%af%80%ed%b0%987/jos.2009.17 http://dx.doi.org/10.1097/00007%ed%af%80%ed%b0%973%ed%af%80%ed%b0%98-200011000-00012 http://dx.doi.org/10.1097/00007%ed%af%80%ed%b0%973%ed%af%80%ed%b0%98-200011000-00012 http://dx.doi.org/10.1097/00007%ed%af%80%ed%b0%973%ed%af%80%ed%b0%98-200011000-00008 http://dx.doi.org/10.1097/01.olq.000019%ed%af%80%ed%b0%97%ed%af%80%ed%b0%988%ed%af%80%ed%b0%99.%ed%af%80%ed%b0%99%ed%af%80%ed%b0%99%ed%af%80%ed%b0%9709.7a http://dx.doi.org/10.1097/01.olq.000019%ed%af%80%ed%b0%97%ed%af%80%ed%b0%988%ed%af%80%ed%b0%99.%ed%af%80%ed%b0%99%ed%af%80%ed%b0%99%ed%af%80%ed%b0%9709.7a http://www.nyc.gov/html/doh/html/survey/survey.shtml patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? kathleen e. turner 1 , sherrilynne fuller 1 1 university of washington, information school and university of washington, center for public health informatics abstract though improvements in infant and maternal mortality rates have occurred over time, women and children still die every hour from preventable causes. various regional, social and economic factors are involved in the ability of women and children to receive adequate care and prevention services. patient-held maternal and/or child health records have been used for a number of years in many countries to help track health risks, vaccinations and other preventative health measures performed. though these records are primarily designed to record patient histories and healthcare information and guide healthcare workers providing care, because the records are patient-held, they also allow families a greater ability to track their own health and prevention strategies. a literature search was performed to answer these questions: (1) what are maternal information needs regarding pregnancy, post-natal and infant healthcare, especially in developing countries? (2) what is known about maternal information seeking behavior in developing countries? (3) what is the history and current state of maternal and/or child patient-held healthcare records, do they provide for the information needs of the healthcare provider and what are the effects and outcomes of patient-held records in general and for maternal and/or child health in particular? specific information needs of pregnant women and mothers are rarely studied. the small numbers of maternal information behavior results available indicate that mothers, in general, prefer to receive health information directly from their healthcare provider as opposed to from other sources (written, etc.) overall, in developing countries, patient-held maternal and/or child healthcare records have a mostly positive effect for both patient and care provider. mothers and children with records tend to have better outcomes in healthcare and preventative measures. further research into the information behaviors of pregnant women and mothers to determine the extent of reliance on interpersonal information seeking is recommended before expending significant resources on enhanced patient-held maternal and/or child healthcare records including storage on mobile devices. in particular, research is needed to explore the utility of providing targeted health messages to mothers regarding their own health and that of their children; this might best be accomplished through mobile technologies. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 keywords: child health services, developing countries, information seeking behavior, maternal health services, medical records introduction around the world in developing nations, maternal and child healthcare has been on the forefront of consciousness for improving the lives of global citizens [1-3]. though improvements in infant and maternal mortality rates have occurred over time, women and children still die every hour from preventable causes [4-6]. in addition, each country has its own policies and challenges with delivering healthcare to its citizens [7-9]. various regional, social and economic factors are involved in the ability of women and children to receive adequate care and prevention services [10, 11]. most importantly, though, is making sure the improvements in maternal and child healthcare and preventative measures in developing countries lead to decreased morbidity and mortality in these vulnerable populations [12-14]. the united nations (un) millennium development goals for 2015 include several goals defined by the world health organization (who) as pertaining to health, particularly in developing countries. these health related goals include: worldwide reduction in maternal mortality by three-fourths and in mortality of children under the age of five by two-thirds from year 2000 levels [15]; forty percent of these childhood deaths are in newborns [16]. only 19 of the 68 priority countries are on track to reach the healthrelated goals for child mortality and maternal health [15]. though many of these struggling countries have been severely impacted by the hiv/aids epidemic [17], the major causes of neonatal death continue to be sepsis and pneumonia, birth asphyxia, complications of pre-term birth, tetanus and diarrhea [18, 19]. the majority of these conditions could be prevented or treated with proper pre-natal, childbirth and neonatal healthcare, maternal and child nutrition and maternal education [18]. given the lack of access to healthcare in developing countries, there have been various measures proposed and enacted to enable patients to become greater participants in their own healthcare [20]. in developing countries, self-care measures are important for empowering people and communities who have limited access to a formal healthcare system to make a difference in their own well-being [19-22]. medical personnel have worked to improve systems for accurately determining higher risk patients, in particular pregnant women who are most likely to need referral for delivery of their babies [4, 19, 21]. other healthcare interventions include timely vaccination, treatment for infectious and parasitic diseases and malaria, prevention of nutritional deficiencies, smoking cessation education and prophylactic therapy for hiv/aids [16, 18, 21]. patient-held maternal and/or child health records (phmr or phcr) have been used for a number of years in many countries to help track health risks, vaccinations and other preventative health measures performed [23-27]. though these records are designed to record patient histories and healthcare information and to guide healthcare workers providing care, because the records are patient-held, they also allow families a greater ability to track their own health and prevention strategies [7, 27]. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 objectives in preparation for a pilot project to transfer a patient-held mother and child health record from paper to a web-enabled cell phone platform, a literature review was needed to help answer these general questions: 1) what are maternal information needs regarding pregnancy, post-natal and infant healthcare, especially in developing countries? 2) what is known about maternal information seeking behavior in developing countries? 3) what is the history and current state of maternal and/or child patient-held healthcare records (especially in developing countries,) do they provide for the information needs of the healthcare provider and what are the effects and outcomes of patient-held records in general and for maternal and/or child health in particular? the revised (2010) kenyan maternal & child health booklet provides a good example of a paper record used currently in a developing country [28-31]. this 17-page booklet is larger than many of the other maternal-child records [27], and has room for recording information regarding one pregnancy and child. most of the seven pages of “maternal profile” seem designed for use by the healthcare provider; it includes the medical, surgical and obstetrical history. there are spaces for recording examination findings from first encounter to delivery. a graph for tracking the mother’s weight gain, preventive therapy schedule, family planning chart, and notes section seem to be the main areas for providing for maternal information needs regarding the pregnancy. the “child health card” section of the booklet seems more designed to provide information to the child’s family. on almost every page, there are notes for parents such as immunization and vitamin reminders, developmental milestones, appropriate weight to height chart, retroviral prophylaxis chart and follow-up, notes, and infant feeding recommendations. methods this study included two related literature searches performed concurrently. databases searched include: cinahl plus, dissertation abstracts, embase, global health library, global health archive, pubmed, science direct, social science research network, web of science, who library database (wholis) and who statistical information system (whosis). for the first query topic the library, information science & technology abstracts (lista) database was also included. searches took place in january and february 2011; articles retrieved were limited to the english language literature. the searches were conceptual in nature. approaching the two questions regarding maternal information seeking and information needs, the first search included the concepts of and . the second search centered on answering the third question regarding patient-held records and their usefulness. this search utilized the idea of , then added in the notion of . the search was expanded by the use of pearlgrowing techniques [32]; applying database-specific subject headings or descriptors from a known article to search for related articles [33]. investigating database-identified related articles, article citations and article reference lists further expanded the search. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 some general search terms were used either combined or separately for each topic. the search terms listed are in a single format, but the format was altered depending on the search criteria and preferential use by each individual database. search strings were also expanded and contracted depending on the number of results obtained in each individual database, and search terms might include: (“mother” or “maternal”), (“child”), (“health” or “medical”), (“information” or “data”), and (“developing” or “undeveloped” or “third world”). to further define the searches, the following terms were added: (“information need*” or “information seek*” or “information behavior”), (“record” or “card” or "booklet"), ("health information system"), (“patient held” or “hand held”) and (“outcomes”). articles focusing on behavior of information seeking in specific places, such as the internet or libraries, were not included. pearlgrowing techniques were especially important for the maternal and child record search. in particular, use of the subject headings and reference list for the 1993, multi-site study, evaluation of the home-based maternal record: a who collaborative [24], proved particularly helpful for locating literature on this topic. results a. maternal information needs and information seeking behavior the literature covering maternal information behavior specifically for medical or health related information needs in developing countries seems rather limited. only eight published papers from six separate studies of information behavior, including health information needs, of women and mothers in developing countries were retrieved using the literature search criteria (table 1). health information needs for family, prenatal and infant care are ranked high in the studies of overall women’s information needs in developing countries [34, 35, 38, 39], and a few studies look specifically at health information seeking behavior in these populations [36, 37, 40, 41]. a few common themes emerge from the available research literature; mothers in the developing countries studied tend to seek medical information and advice for their children and families more commonly than searching for other information needs, and the first source or most common source for information comes from other people. basic infant and child developmental and care information are mentioned as important to mothers in the studies from tanzania and turkey [36, 37, 40]. in order to get a broader view of maternal information behavior, some studies of disadvantaged mothers from developed countries were also included (table 2). while these studies come from different countries and regions of the world, they show some interesting similarities as well as trends in the direction of information behavior. unfortunately, due to the small number of studies and the small number of participants, true generalities cannot be drawn, though comparisons may be possible. the earlier studies from the 1990s in developing countries [34, 35] show women using personal information sources first when seeking information for many reasons including health related. the later studies, and studies from developed countries [36-40, 42-47], indicate that women, both in developed and developing countries, seek a majority of health-related information from their healthcare providers. the one study of adolescents, girls and boys, shows a majority of these young people from sub-saharan africa use mass media sources in addition to school and personal sources to meet their reproductive and sexual health needs [41]. the theme that comes through all of these studies is the idea that pregnant women and mothers from all http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 different societies, both developing and developed, show a preference for receiving health information from a person, whether a healthcare provider or not. mothers in the population of adolescents in sub-saharan africa [41] appear to be the main exception to that finding. b. maternal and/or child healthcare record 1) healthcare providers information needs the articles listed in table 3 are, for the most part, descriptions of various forms of the maternal and/or child healthcare record, and describe the specific information needs of maternal and/or child healthcare providers as they offer suggestions for the data set and format important to collect to provide appropriate prenatal and early childhood care. it seems clear that development proceeded over a number of years to arrive at the most current versions of the maternal and child record in developing countries [27, 31]. currently these records are individualized for each country or region, but include information such as: the names of the mother, father and child; the child’s date of birth; antenatal examination findings; recommended vaccination and prophylactic therapy schedule for the mother and child; growth charts for both the child and pregnant woman; varying levels of advice for care during pregnancy and young childhood; as well as location specific physical parameters and findings such as maternal blood pressure, maternal hemoglobin and child’s developmental and nutritional status. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 1. health information needs studies (concerning mothers, women/families and/or reproductive health) in developing countries study type of study (number of participants) research question* results * [34] fairer-wessels fa. 1990. qualitative survey and interview (#80) what are the daily information needs of urban black south african women, are they generally able to fulfill those needs, how and where do they search and would development of community information centers help? generally these women use interpersonal sources for seeking information needs, and the most commonly sought information is regarding health issues. a community information center sounds like a good idea (no reasons really offered). [35] ngimwa, p, et al. 1997. qualitative survey and interview (#312) what is the media accessibility and use of rural women in kenya? additionally what are their main information needs and information sources? the women in this study tend to use interpersonal sources of information most frequently (60% use friends and relatives, and 34% use professionals as a first information source, with 74.1% expressing satisfaction with source) and the researchers recommend alternative methods for providing information to these women rather than media like radio. women tend to have most questions about healthcare needs (43.3%) and farming/agricultural issues (29.8%). [36] lugina hi, et al. 2001. [37] lugina hi, et al. 2004. qualitative survey interview (#110) qualitative interview + card sorting activity (#110) what are the concerns of first time mothers in dar es salaam, tanzania immediately and six weeks post-partum? what are mothers concerns regarding the post-partum period, and are there better methods for getting at the in this population, some maternal worries change over six weeks, some stay the same. worries were mainly around the baby's general condition (with lesser concern about care and behavior) and the mothers' feelings (with lesser concerns regarding appearance, family reactions, and sexuality), switching to more interests and confidences in these areas after 6 weeks. questions are raised about how to provide timely http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 information in developing countries? information. overall between 16 weeks post partum, worries decrease from 29%-15% (about baby from 31%-14% & self from 30%-20%) and interests (overall 38%-42%, baby 41%50%, self 38%-41%), and confidences (overall 32%-43%, baby 29%-36%, self 32%-39%) increase. this study will help healthcare providers to understand the types of information these women are looking for post-partum. additionally, using card sorting seems to get better response than just interview alone for concerns, interests, etc. of first time mothers. [38] mooko, n. p. 2005. [39] mooko, n. p. 2002. qualitative interview and focus groups (#60) what are the information needs and information seeking behaviors of rural botswanan women? the most common information need of women in the study related to health information for the women and their families, and the most common and helpful information source was a healthcare provider. [40] ertem io, et al. 2007. random survey and interviews (#1200) what do mothers in a developing country (turkey) know about young child development? in general, mothers felt that developmental milestones occur later than actual for normal childrenthe majority of women did not know that sight (52%), vocalization (79%), social smiling (59%), and overall brain development (68%) begin in the early months of life. women with more education and fewer children had a better idea of actual childhood development. this study suggests that healthcare providers need to educate mothers in child development for optimum provision of pediatric healthcare. [41] bankole a, et al. 2007. national household survey what is the knowledge level of young teens in four sub-saharan countries (burkina faso, malawi, uganda, and ghana), these kids use multiple information sources, most commonly mass media (45.6%78.9% depending on gender and country), but also teacher/school (17.7%-69.8%, depending on gender and country) and friends http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 and how do they fill their information needs regarding sexual behavior, stis and pregnancy? (18.2%-59.7%, depending on gender and country). the researchers suggest that inschool education programs might be most effective. * see notes regarding research question(s) and results table 2. health information needs studies of mothers (particularly disadvantaged mothers) in developed countries study type of study (number of participants) research question* results* [42] green jm, et al. 1990. prospective survey (#825) how do expectations of childbirth coincide with satisfaction, especially in the realm of feelings of control and adequate information reception on the part of the mother (southeastern england)? in this study, high expectations did not seem to lead to poor outcomes, and lower expectations seemed to lead to less satisfaction. women wanted to retain control as much as possible and many reported that greater information given to them by their healthcare providers about what to expect led to a greater feeling of control. [43] baker lm, et al. 2007. qualitative interviews (#30) what are the health literacy levels, and information seeking behaviors toward the vaccines given to their children of this group of mothers? in this very small sample, most of the women were unaware of the purpose of the vaccines their children were receiving (26 of 30). health literacy levels of this group of detroit mothers were relatively low, and they tended to receive their information regarding their children's vaccines from the healthcare provider (22% from doctors, 18% from clinic nurses, the rest from 1-9% from 10 other sources). [44] smith sk, et al. 2009. qualitative interviews (#73) how do education levels and health literacy affect people's information needs and expectations for health decision-making? in this population from sydney, australia, more highly educated/health literate patients seem to take a higher responsibility for making their own decisions regarding health care, whereas less educated patients relied more on health care providers to make decisions to which they would either agree http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 or disagree. [45] shieh c, et al. 2009. standardized test of health literacy and interview (#143) how do health literacy levels relate to the use of health information sources and barriers to information seeking in low-income pregnant women in urban midwestern u.s.? higher levels of health literacy were related to a greater ability to use multiple information sources with lower barriers to information seeking. results suggest that information seeking skills should be taught to patients with lower health literacy. both the high (85.3%) and low health literacy (14.7%) group used healthcare professionals most frequently (low 90.5%, high 74.6%), with books/brochures (low 57.1%, high 58.2%) and family and friends next most frequently (low 57.1%, high 51.5%). [46] shieh c, et al. 2009. qualitative interviews (#84) what are the information seeking behaviors (information needs and barriers) in this population of lowincome pregnant women? in this urban midwestern u.s. population it was shown that information seeking was highest in those women with the highest needs (asthma and first pregnancy) and the lowest barriers to obtaining information. also showed that healthcare providers were the highest source of information. [47] shieh c, et al. 2010. survey and standardized testing (#143) do health literacy, positive measures of mother's fetal locus of control and maternal self-efficacy correlate positively with health information seeking in this midwestern u.s. population of lowincome pregnant women? feelings of maternal control toward fetal wellbeing (r=0.27, p=0.003) and self-efficacy (r=0.33, p=0.0004) were positively correlated with maternal information seeking. health literacy was not (r=-0.05, p =0.63). in this study, low health literacy was correlated with a feeling of lowering self-fetus control, in other words, these pregnant women tended to rely on information from healthcare providers more than women with higher health literacy. * see notes regarding research question(s) and results http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 3. maternal and/or child healthcare record information needs of providers study type of study/document research question* results* studies of patient-held records [48] hartfield vj. 1973. descriptive is there a better method of record keeping for mothers in developing countries? this is an early proposal for use of card to improve record keeping. positive outcomes for phmr suggested. [49] dissevelt ag, et al. 1976. descriptive what are features of record to facilitate detection of highrisk pregnancy in rural kenya? earlier kenyan maternal card, positive benefits suggested. [50] sims p. 1978. descriptive what are features of record to facilitate detection of highrisk pregnancy? provider information, dense information, not for illiterates, ph card prototype. positive value felt by author, especially since patient generally has information availableimportant especially in case of emergency [51] shah kp, et al. 1981. descriptive what are features of indian record to facilitate detection of high-risk pregnancy? description of card, apparently useful to help detect risk factors. [52] chabot ht, et al. 1986. descriptive what are features of record to facilitate detection of highrisk pregnancy? prototype for pictorial card, describing the need for testing and use in guinea bissau where most pre-natal care done by illiterate tbas. results unknown. felt to be necessary and helpful for helping tbas, but difficult to get right. suggestions for single card usable for http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 both lit and ill to allow mother to carry only one card. area determines different procedures done by each. [23] kumar v, et al. 1988. descriptive what are features of record to facilitate detection of highrisk pregnancy/improve quality of care in india? description of card, apparently useful to help detect risk factors. benefits of using for illiterate traditional birth attendant (tba) in order to aid in earlier detection of risks and improved maternal self-care. [25] world health organization. 1992. instructional booklet what are guidelines for implementing home-based child health records? in depth instructions for implementing phcr card or booklet. specifications for how to implement and how to alter to fit the particular circumstances for each area of implementation. [26] world health organization. 1994. instructional book what are guidelines for implementing home-based maternal records? in depth instructions for implementing phmr card or booklet. specifications for how to implement and how to alter to fit the particular circumstances for each area of implementation. studies of clinic-held records [53] poulton em. 1966. descriptive reasons for record keeping for maternal child health care in developing countries. basic outline of the purpose of records. [54] essex bj, et al. 1977. descriptive what are features of record to facilitate detection of highrisk pregnancy? early card for providers’ use, not for illiterates, card prototype reminder of need to test http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 against existing. the new card demonstrated a high rate of agreement between providers, and was felt to be useful in tanzania [55] alisjahbana a, et al. 1984. observation (#20) how can we improve traditional birth attendants’ (tba) reporting of high-risk births in indonesia? this study showed that tbas able to report, assess, and respond accurately if trained and risk indicators defined in a way they understood. [56] kennedy i, et al. 1984. descriptive what are the reasons for restructuring record in botswana? ability to follow pregnancy by use of an obvious graph to compare between visits seems helpful to catch problems. not necessarily designed for developing countries studies of electronic records [57] moidu k, et al. 1992. expert consensus what is the essential data set of an electronic maternal health record? examines feasibility of creating and using the data set, data set listed. importance is that data set might be different for each location. data sets being tested in sweden and india. [58] phelan st. 2008. descriptive what are the comparisons between the current well-organized and useful paper record to an electronic record (u.s.)? the authors clearly don't want to lose the positive aspects of the pre-natal record that has been working well for a number of years, but recognize the portability and potential for back-up and legibility of the electronic record, while recognizing the inherent difficulties of setting up a new system. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 2) patient held records for a number of years, a variety of developed and developing countries have used patient-held maternal health records and/or parent-held child health records [25, 26, 48-52, 59]. more recently, as described above for kenya [31], countries have started adopting patient-held combined maternal and child health records. these records are frequently designed with guidance from the who, though each jurisdiction is encouraged to develop the record best suited to its culture and populace [25, 26]. the literature review results fall into a few categories based on whether utility of the record to the patient/parent (tables 4, 5 and 6) or the healthcare provider (tables 7, 8 and 9) was the main focus of the study; also whether the record was specific for maternal and/or child healthcare or for other types of healthcare. additionally, findings tended to vary for studies carried out in developed versus developing countries. a) utility to patients the majority of results are neutral for the effects of the patient-held maternal and/or child record in the studies conducted in developing countries (table 4). increasing patient education was felt to be one way to improve the card’s utility in all four of the studies with neutral results [59, 61-63], and use and understanding of the card is felt to be key in the two positive outcomes [59, 60]. where noted, loss of the record was not felt to be a significant issue [59, 63]. in the 13 studies showing a positive outcome for the patient-held maternal and/or child record studies in developed countries [64-76], words like confidence, control, access (better informed), satisfaction, and communication (interaction) were repeated (table 5). in addition, in eight of the nine studies where recorded, there were few or no missing or lost records, and some families retained the records for many years [65-70, 72, 75, 77]. the two studies showing inconclusive or neutral results were focused on the health outcomes of the record [76, 77]. all eleven studies of the patient-held (not maternal and/or child) records were carried out in developed countries (table 6). results in these studies were variable. the six positive outcomes were qualitative assessments of patient benefit [78-83]. one of the two studies with negative results reports less satisfied patients, and the other reports a potential imbalance of power relationship [81, 82]. the seven studies including neutral results, were just that, the results were inconclusive [82-88]. where noted, patients are generally willing and able to carry the card [80]. b) utility to care providers the care provider is most likely to be influenced by the results in the 15 studies of the patient-held maternal and/or child records in developing countries (table 7). the ten positive results demonstrated here are, for the most part, improved outcomes in healthcare results or http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 preventative measures such as detection of risk, quality of care, higher rates of care, as well as increased educational opportunities [24, 63, 89-96]. the six studies with neutral results can show no conclusive positive results, but provide a positive overall feeling toward the record [61, 96-100]. in studies where noted, the majority of women were able to keep track of the record even if they weren’t always brought to healthcare provider visits [63, 92, 94, 96]. the seven studies of patient-held maternal and/or child records from developed countries (table 8) show results that most likely to influence care providers. these outcomes offer a more mixed view of the effects of the records. definite positive benefits were shown with children’s immunizations [69, 101], return of record following education about its importance [103], and impressions of improvement in communication, access and care [68, 102]. neutral results center on management of the record [69, 103] and inconclusive health results [76]. negative results arise from confidentiality concerns, increase in burden of work, size of the record, and increased surgical intervention [68, 76, 104]. this final concern noting increased surgical interventions with possession of the patient-held record might be considered positive in developing countries where detection of risk factors and elucidating the need for referral are crucial to the records’ function [89-92]. the majority of patients were able to produce records when requested in studies reporting this factor [68, 69, 103]. the three final studies (table 9) of the influence on care providers of the patient-held (not maternal and/or child) records show some positive benefits in compliance in patients with possession of the record [81], though the other two studies demonstrate the patients just not using or carrying the record [105, 106]. the studies listed in tables 4-9 delve into the usefulness of and outcomes for the patient-held record. in total, 48 studies were listed in the six categories of type of patient-held record: (maternal and/or child or not,) care provider or patient most influenced/effected, and research done in developed or developing country. nine (one study in two categories) of the studies are felt to have mixed results [59, 68, 69, 76 (twice), 81-83, 96, 103], and six of the studies are felt to concern both patient and care provider [61, 63, 68, 69, 76, 81]. of these results, 37 show positive effects or influences, 24 show neutral effects or influences, while only five studies show negative effects or influences produced with use of a patient-held health care record. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 4. who studied: what studied – where patient: patient held maternal and/or child records developing countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [60] kusumayati, a, 2007. repeated cross-sectional survey (#611, #621, #630) what are the effects of the mch in western sumatra on using maternal health services? the mothers using (not simply owning) the mch had 2.5 times better knowledge of the benefits of some pre-natal care measures, and were 3 times more likely to seek out needed care. [59] nakamura y 2010. descriptive what is the history of the mch handbook in japan? this study included here, as the mch handbook was first distributed in japan in 1947. the positive benefits of the mch handbook include ease of the main concerns are the costs (though less than multiple separate cards), the fear of loss (not found to be a significant problem), and the uneven use of the cards http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 understanding, access to child and maternal health information, and having records available when needed. depending on the quality/amount of care available. [61] harrison d, et al. 1998. descriptive / interview (#185) what are the opinions of mothers/caregivers (#150) and health care providers (#35) regarding accuracy and completeness of the road to health card in cape town, south africa? health care providers like the concept, but would like information to be in a more useful format. points out need to determine what information is important to family and healthcare providers in order for them to actually fill out all information. [62] mahomed k, et al. 2000. descriptive /interview (#51) how feasible is having a phmr in rural zimbabwe, and do mothers understand the reasons for the record? the introduction of the record seems feasible, but much more education of mothers is http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 needed for them to understand value as only 49.1% returned at end of study. [63] tarwa, c., et al. 2007. survey (#300) is the south african road-to-health card brought to consultations and used by health care providers? the rth card is not brought to 48% of consultations. adults mostly (72%) thought they were only to bring the card to wellbaby clinics. care providers are missing an opportunity to educate and provide health monitoring. * see notes regarding research question(s) and results http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 5. who studied: what studied where patient: patient held maternal and/or child records developed countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [64] draper j, et al. 1986. case controlled survey (#171) what are cambridge (uk) women's views on carrying mhr? generally positive view (71/88 liked carrying record; 83/88 thought there were advantages), women appreciate access to information. [65] elbourne d, et al. 1987. randomized controlled trial (#290) what are women's preferences for carrying own mhr (oxford)? positive effects of carrying more complete record as opposed to notes are: possibly decreased clerical time, a greater sense of feeling of control, confidence talking with medical personnel. no increase in lost notes over system. [66] lovell a, et al. 1987. randomized controlled trial (#246) what are women's preferences for carrying own mhr (london, uk), and does carrying own increase satisfaction with care? positive effects of carrying more complete record as opposed to notes are: possibly decreased clerical time, increased feeling of control. decrease in lost/mislaid notes (0 for phmr) over system (25%). [67] saffin k, et al. 1991. case controlled survey (#452) how well are children's records kept by parents, and do parents who have phr (#284) and those who don’t (#168) prefer to keep their children's records (oxfordshire)? parents who kept their children's records had more positive view of practice (75% phr vs. 26% nonphr. appreciated access, 90% phcr available for audit. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 19 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [68] charles r. 1994. survey and case control comparison of physical records (#155) is the parent held record an effective means of communication, does it derive any benefit if yes, and is the north staffordshire phr a good quality source of patient information for parents (#100) and professionals (#55)? the vast majority of parents (8799%), nurses (67-100%) and health visitors (70-100%) agreed with a smaller majority of doctors (53-78%) that the child's individual record plus the information on child healthcare helped improve communication and care in at least 3 areas. audits compared to clinic held records revealed significantly more information recorded on the parent held record. [69] jeffs d, et al. 1994. random sample interview (#622) are phr retained and used to appropriately to record immunizations, and are parents and providers satisfied with their use (new south wales)? the majority (93%) of parents retained their records, with the majority having at least one (91%), and a smaller majority (68%) having all immunizations recorded in the record by. the majority of providers are (80-90%) satisfied with the use of the record. [70] webster j, et al. 1996. descriptive /survey (#200) what are women's preferences for carrying own mhr in brisbane, australia, and does carrying own increase satisfaction with care? greater satisfaction with care in phr group, though 36% forgot record at least once in at least 5 visits. women felt increased control with phr. [71] homer cs, et al. 1999. randomized controlled trial (#150) what are women's preferences for carrying own mhr (as opposed to a care card,) and does carrying full record increase satisfaction with care (new south wales)? women tended to feel more confident carrying full record, and reported a significantly greater feeling of control and access to information about their pregnancy; 89% would choose to do so again. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 20 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 5 (continued) who studied: what studied where patient: patient held maternal and/or child records developed countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [72] phipps h. 2001. qualitative interview (#21) what is impact of carrying own record during pregnancy (sydney, australia)? great majority of women favored carrying their own record in this and subsequent pregnancy, felt themselves and family to be better-informed, minimal worry about losing record. [73] usha kiran ts, et al. 2002. prospective survey (#72) what are women's preferences for carrying own mhr and is it an increased burden (south wales, uk)? the majority (90.2%) of mothers preferred to carry own notes; feeling it improves access to their case notes. [74] shaw e, et al. 2008. randomized controlled trial (#193) does secure access to pre-natal records lead to higher access to online information and greater satisfaction with care (hamilton, ontario)? study group accessed prenatal information much more frequently, and average of 8.6 more logins (including own record: 84.2% of time) both groups satisfied with information provided. [75] clendon j, et al. 2010. qualitative – interview (#35) what is the impact of the phcr in new zealand this is a good tool for improving interaction between mother and nurse. mothers keep the record for years; sometimes pass http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 21 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 them on to child when grown. [76] brown hc, et al. 2004. systematic review (3 trials) what are the effects of having women carry their own case notes during pregnancy? positive patient view of more control of care, and an increased sense of satisfaction. inconclusive health outcomes [77] bjerkeli grøvdal l, et al. 2006. randomized controlled trial (#309) do phr have positive effect on parents' knowledge, collaboration with or utilization of healthcare in norway? no health effect or improvement in other measures noted by parents. majority of parents carried record. * see notes regarding research question(s) and results http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 22 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 6. who studied: what studied where patient: patient held records in general developed countries type of study research question * results (positive outcome of having record) results (neutral) results (negative outcome of having record) [78] giglio r, et al. 1978. descriptive /survey (#30) are people interested in carrying their own phr (amherst, ma)? study shows that patients are willing to make the effort to carry own card, further study needed to determine if makes a difference in outcomes [79] liaw st, et al. 1998. randomized controlled trial (#72) what is the impact of a phr on responsibility, information sharing and preventative health care of patients holding a phr in adelaide, australia? statistically significant improvement noted in responsibility and information sharing of patient, and may help patient awareness/participation in own care. [80] jerdén l, et al. 2004. descriptive /survey (#418) to what extent do patients report a lifestyle change when they have a phr? swedish study indicates positive lifestyle changes in 25% of those patients who received an informative health booklet (and record) [81] dickey ll. 1993. literature review (#7 trials) have studies shown any benefit to phr for preventative care? some positive benefits for patient involvement in their own care in the majority of studies. immunization records for children seem to show the highest positive value. future possibility of electronic mini-records. potential barriers include disruption of traditional power barrier, and perception of increased time required. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 23 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [82] lecouturier j, et al. 2002. randomized controlled trial (#189) does holding own record increase cancer patient satisfaction and positive feelings about communication with care provider (newcastle-upontyne, uk)? healthcare staff had positive impression. 53% with phr found it helpful. patients with phr less satisfied (58% vs. 86% very satisfied) with information given, perhaps due to higher expectations. [83] williams jg, et al. 2001. randomized controlled trial (#501) do patients feel phr improves quality of life (wales, uk)? improved sense of control of cancer management for some patients. no demonstrated improvement in quality of life for cancer management. 52% of patients would have preferred not to have phr. [84] drury m, et al. 2000. randomized controlled trial (#650) does holding own record increase patient satisfaction (oxford)? no demonstrated improvement in satisfaction for cancer management. [85] cornbleet ma, et al. 2002. randomized controlled trial (#244) does holding own record increase cancer patient satisfaction in urban scotland? patients like it, but no difference noted on patient satisfaction and imposing on the providers on top of other records may be too much on workload. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 24 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 6 (continued) who studied: what studied where patient: patient held records in general developed countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [86] lester, h, et al. 2003. randomized controlled trial (#201) do patients in birmingham, uk feel that phr improves outcomes? no good evidence that phr helped schizophrenics, but not apparently harmful, and a higher symptom score was associated with not having record. [87] gysels m, et al. 2007. systematic review (#12 studies) do phr improve patient satisfaction with communication and information exchange? extensive literature review into efficacy of phr to improve patient satisfaction for specific cancer patients. random controlled trials show different outcomes (negative/neutral) than qualitative studies that show a more positive outcome. provider attitude and use of phr seems important in outcome and efficacy. [88] ko h, et al. 2010. systematic review (#14 trials) is there any improvement in outcomes or patient satisfaction with phr in chronic disease management? no demonstrated improvement in patient satisfaction measures and communication or care outcomes with holding phrs in chronic disease management in developed countries. * see notes regarding research question(s) and results http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 25 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 7. who studied: what studied where care provider: patient held maternal and/or child records developing countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [89] kumar v, et al. 1981. descriptive (tbas from 15 villages) what are features of record to facilitate detection of high-risk pregnancy in india? description of card, apparently useful to help detect risk factors. benefits of using for illiterate tba in order to aid in earlier detection of risks. [90] watson ds. 1984. descriptive survey (#53 notes in 198081 and #60 in 198283) what are features of record to facilitate detection of high-risk pregnancy? early record for in-clinic use by australian aboriginal health workers. equivalent results to normal records, results are positive. [91] abraham s, et al. 1985. house-to house survey (#400) what features of record are needed to improve quality of care and improve record keeping (vellore, india)? mchcc evaluation reveals positive effects on quality of care, detecting risks. improvement needed in stressing importance for educating mothers/families, as 7% of mothers lost record and 18% discarded it following sterilization. [92] abraham s, et al. 1991. non-randomized control (#2446) does provision of phmr card improve outcomes in pregnancies in rural india? some positive outcomes for referral and knowledge of people involved knowledge higher for most measures in women with phmr. good acceptance by families, but suggestions for greater acceptance. [24] shah pm, et al. 1993. large, multi-center collaborative comparative pre/post intervention study (#13 in #8 evaluate the function of the phmr following set of who guidelines. substantial improvement in maternal and neonatal care, and continuity of care in areas using phmr (examples: philippines 91-100% vs. 36.6-51.9%; zambia 93.5% vs. 49.8%). records adapted to local situation. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 26 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 countries) improvement noted in maternal knowledge for self care. [93] daly ad, et al. 2003. interview survey (for #177 children and #220 women) do opportunities for vaccination get missed in swaziland? in this study, children and adults with health card present less likely to be a missed opportunity for vaccination. [63] tarwa, c., et al. 2007. survey (#300) is the south african road-to-health card brought to consultations and used by health care providers? the rth card is not brought to 48% of consultations. adults mostly (72%) thought they were only to bring the card to well-baby clinics. care providers are missing an opportunity to educate and provide health monitoring. [94] corrigall j, et al. 2008. household survey (#3705) what is level of routine immunization coverage in the western cape? in this study, possession of road to health card is highest predictor for vaccination coverage, and children possessing the card were 39.5 times more likely to be vaccinated. [95] osaki k, et al. 2009. 1997 and 2002/3 indonesian demographic and health survey what is level of routine immunization coverage? ownership of mch booklet positively associated with young children's full vaccine coverage (70.9% vs. 42.9%) in indonesia. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 27 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 7 (continued) who studied: what studied where care provider: patient held maternal and/or child records developing countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [96] mukanga do, et al. 2006. random household interview survey (#260) what factors contribute to family having and retaining phcr in uganda? there is a positive relation to improved health with card retention. children with a card were 10 times as likely to be fully immunized. mothers don't receive card as frequently if they don't use a health care center. children delivered at a healthcare facility were 4 times as likely to have card; children who had been to a facility in the past 3 months were 2 times as likely to have card. [97] chabot ht, et al. 1990. literature review and descriptive survey would including pictorial and written risk indicators make a single phmr more useable for all prenatal caregivers? includes literature review of current mhr in use and suggestions for single card usable for both literate and illiterate health care providers to allow mother to carry only one card. area determines different procedures done by each. example from mali. [98] kumar r. 1993. descriptive/ interview (#14) does the simplified mhr improve workload and improve statistical reporting in rural india? the simplification decreased the workload for healthcare workers, but no or minimal improvement in http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 28 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 reporting of vital statistics. [99] goldman n, et al. 1994. data from the 1987 encuesta nacional de salud materno infantil (national survey) how does the official government record of immunization in guatemala compare with phr and maternal recall for obtaining a more accurate view of immunization levels? compares (with great limitation) data obtained from the card as opposed to maternal recall-is likely to be at least as/or more accurate than the government (potentially overestimated record). [61] harrison d, et al. 1998. descriptive / interview (#185) what are the opinions of mothers/caregivers (#150) and health care providers (#35) regarding accuracy and completeness of the road to health card in cape town, south africa? most health care providers (80%) support the concept, but most (80%) would like information to be in a more useful format. points out need to determine what information is important to family and healthcare providers in order for them to actually fill out all information. [100] nuwaha f, et al. 2000. retrospective comparison of national survey did immunization levels improve after introduction of vaccination cards and vitamin a supplementation in uganda? immunization cards may have been seen as proof of vaccination and caring parent. people with cards seemingly get better care. vaccine levels increased after introduction of cards and vitamin a supplementation, though causality could not be determined. * see notes regarding research question(s) and results http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 29 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 8. who studied: what studied where care provider: patient held maternal and/or child records developed countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [101] mcelligott jt, et al. 2010. governmentprovided data analysis are phr for childhood immunizations positively correlated with being up-to-date on vaccines? in us, especially with more disadvantaged families, holding vaccination record associated with higher rates of immunization; odds for child being up-to-date determined as 62% greater for children with phr. [102] macfarlane a, et al. 1990. retrospective study (#239) what are the reactions of general practitioners and health visitors of phcr? in oxfordshire, the majority of providers (over 90%) with experience with phr have positive response to phcr due to ability to access information, minimal experience of loss. providers without experience much more uncertain, only http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 30 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 59% view phr positively. [103] toohill j, et al. 2006. audit /survey (#1256) are phmr returned with mother at time of delivery, and does education improve return rate (australia)? the majority of mothers returned their records. compliance numbers increased over time with education on importance of recordkeeping (82 to 88.5% increase in compliance). there were some issues for healthcare providers for maintaining record completeness if record not available. [69] jeffs d, et al. 1994. random sample interview (#622) are phr retained and used to appropriately to record immunizations, and are parents and providers satisfied with their use (new south wales)? the majority (93%) of parents retained their records, with the majority having at least one (91%), and a smaller majority (68%) having all immunizations recorded in the record by. the majority of providers are (8090%) satisfied with the use of the record. a smaller than hoped for number of providers (2979%) had the purpose of the phr explained to them, and a wide range in the professionals who used the records (3096%). http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 31 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [68] charles r. 1994. survey and case control comparison of physical records (#155) is the parent held record an effective means of communication, does it derive any benefit if yes, and is the north staffordshire phr a good quality source of patient information for parents (#100) and professionals (#55)? the vast majority of parents (87-99%), nurses (67-100%) and health visitors (70-100%) agreed with a smaller majority of doctors (53-78%) that the child's individual record plus the information on child healthcare helped improve communication and care in at least 3 areas. audits compared to clinic held records revealed significantly more information recorded on the parent held record. doctors expressed concerns about maintaining confidentiality, extra burden of work in maintaining the records, the size of the record and fears that patients wouldn't bring the record to clinic visits (this final concern may be dispelled by the increased amount of information recorded in the phr). http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 32 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 8 (continued) who studied: what studied where care provider: patient held maternal and/or child records developed countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) [76] brown hc, et al. 2004. systematic review (3 studies) what are the effects of having women carry their own case notes during pregnancy? inconclusive health outcomes. providers report an increase in the number of surgical interventions with women carrying their phr. this might be a positive finding in developing countries where the problem is lack of intervention in highrisk cases. providers report an increase in the number of surgical interventions with women carrying their phr. this might be a positive finding in developing countries where the problem is lack of intervention in highrisk cases. [104] wilkinson sa, et al. 2007. descriptive survey (#7) /review discussion (#25+) what are the effects of having women carry a new enhanced record during pregnancy (queensland)? care providers felt that the new record was too large for the patient to carry, and contained too much information to be useful to mother. suggested a smaller patient-centered document for mother, and full record to be kept in clinic. * see notes regarding research question(s) and results http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 33 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 table 9. who studied: what studied where care provider: patient held records in general developed countries type of study research question* results (positive outcome of having record) results (neutral) results (negative outcome of having record) i. [81] dickey ll. 1993. quasi experimental comparison (#25) is patient compliance with preventive care guidelines improved with phr (san francisco, ca)? some positive benefits noted by 54-82% of careproviders for 7 separate parameters, with increased compliance providing preventative care in study groups (9.3-11.6% higher compliance than control). [105] atkin pa, et al. 1995. prospective survey (#187) are medication phr cards used (sydney, australia)? for older population in sydney, australia, medication cards don't seem to be used (presentation of card dropped from 61% to 23% over 12 months) or improve compliance in research population (21% of users said card helpful). http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 34 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [106] dijkstra rf, et al. 2005. randomized controlled trial (#769) does phr improve quality of care for diabetes patients in the netherlands? modest improvements in patient health parameters. disappointing results on maintaining card, 36% using card at end of study. * see notes regarding research question(s) and results http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 35 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 discussion a. maternal information behavior though the number of information behavior studies located in this literature review is quite limited [34-47], the sense one gets from them is that families, in particular mothers in developing countries, are interested in information about healthcare issues for their family. while these studies come from different countries and regions of the world, they show some interesting similarities. generalization of mothers’ information behavior is not possible due to the small number of studies and participants. in the studies that measure all types of information seeking behavior, health information needs rank high in the list of overall women’s information needs in developing countries [34, 35, 38, 39]. the few studies that look specifically at health information seeking behavior in these populations [36, 37, 40], show that mothers studied in the developing countries tend to seek medical information and advice for their children and families more commonly than searching for other information needs, and the first or most common source for information comes from other people. there is some indication that these mothers are interested in information regarding child development and care. another common theme in the studies from both developed and developing countries is that mothers from diverse backgrounds prefer to receive health information directly from their healthcare provider. the one exception to this might be mothers in the population of adolescents in sub-saharan africa [41], though it is also possible that the nature of the information or the population involved lends itself to a different preferred mode of delivery. these findings lead one to consider very carefully how mothers might use a home-based healthcare record as a source of information regarding their own and their children’s care. the literature retrieved in this review puts forward the idea that pregnant women and mothers from all different societies, both developing and developed, show a preference for receiving health information from a person, whether a healthcare provider or not. it seems likely, that unless there is a demographic shift in information behavior, mothers may not choose to use information provided in any format of healthcare record. instead they may continue to seek out interpersonal sources. b. maternal and/or child healthcare record the earliest studies retrieved regard maternal and child healthcare records in developing countries, and mainly consist of how-to diagrams with the care provider/designer demonstrating their ideas about creation of these records. due to the descriptive nature of most of the articles listed in table 3, the assumption was made that they reflected the information needs of their healthcare provider and agency creators. the information needs of healthcare providers and other healthcare agencies must be inferred from the proposals and guidelines developed for the production of maternal and/or child healthcare records. the progression shows some measure of the evolution of these records over time [24-26, 47-52]. the other studies retrieved from the search in all categories (tables 4-9), delve into the usefulness and outcomes of the patient-held record. very few negative results noted for either healthcare provider or patient in the patient-held record. in the patient-effected categories http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 36 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 (tables 4-6), the most patient-noted positive effect in developing countries was the increased knowledge of the benefits of healthcare, as well as having the records available when needed [59, 60]. a lack of understanding of the record’s use pointed to a need for greater education in studies where the patient effect was neutral [61-63]. the effect of the patient-held record seems most positive on patients holding maternal and/or child records in developed countries. these mothers, for the most part, tend to relate positive feelings of confidence, control, access (feeling better informed), satisfaction, and improved communication and interaction during the healthcare process (table 5). as mothers in developing countries become better informed and want to play a greater role in their own care, perhaps carrying their own maternal/child records can engender these same feelings. in contrast to mother and child records, most other patient held records have not shown to be of significant benefit to either the patient or the healthcare provider (tables 6 and 9). the results for the influence of patient-held records on care providers was more mixed (tables 7-9). care providers in developing countries seemed to recognize the most positive outcomes in terms of improving health and prevention practices with patients carrying the maternal and/or child record (table 7). though follow-up study needs to continue, the improvements noted for patients are encouraging. in addition, the majority of studies, where this was measured [59, 63, 65-70, 72, 75, 77, 80, 91, 94, 96, 103], showed that patients tend not to lose patient-held maternal and/or child records, though some of the general patient-held records were more readily lost to follow-up [105, 106]. this finding seems significant and may be worth continued study in determining the importance of these records, especially to families in developing countries. in general, these studies show some positive outcomes related to the use of the patient-held maternal and/or child record. the most positive effects relate to the patient’s (mother) emotional state and feelings of control and access to information, particularly in developed countries, and results of improved health outcomes with the patient-held maternal and/or child record in developing countries. the fact still remains that 49 of the 68 priority countries are not on track to reach the un millennium development goals for 2015 [15], and these positive results need to be further leveraged to help developing countries meet their goals for decreasing mortality and improving health. study limitations the results obtained in the literature review may have suffered, both from the inability to find all applicable research in the field, as well from a limited time frame for study. in particular, it was impossible to pursue all potential sources for research in information behavior and patient-held records. the research questions addressed in the studies on patient-held records retrieved from the literature search were quite varied, and therefore difficult to compare aside from impressions of the effect or influence of the record on the patient and/or care provider. in addition, several of the studies produced mixed results, further confusing the comparison. finally, reviewer bias, access to articles and limitations to the english language inevitably factored into which search avenues were pursued and which articles were included in the study. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 37 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 recommendations the information behavior of women, particularly in developing countries, needs further investigation. it is unclear whether the childcare and healthcare information provided in existing patient held, maternal-child healthcare records, such as the kenyan maternal & child health booklet [31] and others [27], meets the needs of mothers and families. the literature suggests that pregnant women and mothers (tables 1 and 2) prefer to seek information from human sources. in particular, mothers appear to prefer to receive information from healthcare providers. healthcare providers must also be included in any discussion of maternal-child healthcare records; providers’ input on needed data is crucial to the success of any healthcare record (table 3). several studies have demonstrated the use of mobile technology, such as cell phones and personal digital assistants (pda), in healthcare in both the developed [105-111] and developing [112-115] world. protocols have been developed for creating healthcare forms and questionnaires for small mobile devices [114, 116-118]. the technology currently exists for enhancing patient-held records for storage on web-enabled mobile devices [113, 119]. healthcare providers currently use short message services (sms) to send targeted health-related messages to their patients [109, 115, 120]. in addition, electronic devices allow for communication beyond just text and the pictorial representation allowed by paper records; cell phones allow for photographic and graphic visual display, as well as voice and text messaging, electronic storage, and two-way capabilities [121, 122]. the next step in evaluating the appropriateness of web-enabled cell technology for a patient-held maternal-child healthcare record in developing countries is to determine whether a mobile platform can meet the information needs of women and families, as well as the healthcare providers in the region. currently a pilot study is underway in peru to “[d]evelop an interactive computer-based system and a common mobile phone-based platform to support maternal and child care among pregnant women” [123]. this project, a public-private partnership, also hopes to improve health services to pregnant women by increasing access to timely information, allowing greater monitoring capability by the health system, and finding empirical evidence of the social and economic impacts of mobile technologies. going forward, further research is needed to explore the utility of providing targeted health messages to mothers regarding their own health and that of their children. additionally, an assessment of the infrastructure and current practices must be complete to determine if this might best be accomplished through mobile technologies [124, 125]. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 38 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 conclusions information behavior of women, in particular disadvantaged pregnant women and mothers in developed and developing countries and other caregivers in developing countries, seems to rely most commonly on seeking information from interpersonal sources. for health-related information, most of these women look to healthcare providers. more study is necessary to determine if delivering health information in an alternative format would be acceptable or well received. the development of maternal-child healthcare records in developing countries over time offers the best insight into the basic information needs of maternal-child healthcare providers. the presence of a maternal and/or child healthcare record appears to have a positive effect, for the most part, on both care providers and patients in developing countries. in addition, the presence of a maternal and/or child healthcare record appears to have a positive effect, for the most part, on patients’ sense of control and feelings of satisfaction in developed countries. other types of patient-held records, in developed countries in particular, have not been as positively received. notes due to space limitations, it was necessary to restate and/or paraphrase research questions and study results listed in the tables above. the first author is responsible for interpreting research questions gleaned from the abstract, introduction and/or problem sections of the articles reviewed. the first author is also responsible for the interpretation and inclusion (or exclusion) of results obtained from the abstract and/or results sections of the articles reviewed. acknowledgements i would like to thank sherrilynne fuller and grace john stewart, md, phd, mph and other members of the center for integrated health of women, children, and adolescents at the university of washington for suggesting i pursue this literature review as the culminating project of my mlis degree. in addition i’d like to thank my family for enduring the many weeks of my “absence” while completing this project. http://ojphi.org/ patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 39 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 references [1] world health organization. media center: millennium development goals: progress towards the health-related millennium development goals [internet]. [place unknown]: world health organization; c2011 [updated 2010 may; cited 2011 mar 18]. available from: http://www.who.int/mediacentre/factsheets/fs290/en/. [2] world health organization. department of child and adolescent health development. highlights: child and adolescent health and development progress report 2006-2007. geneva: who press; 2008. 21 p. [3] world health organization. department of child and adolescent health development. highlights: child and adolescent health and development progress report 2009. geneva: who press; 2010. 41 p. [4] world health organization. maternal health and safe motherhood programme, division of family health. mother-baby package: implementing safe motherhood in countries. geneva: world health organization; 1994 [cited 2011 mar 18]. 89 p. available from: http://whqlibdoc.who.int/hq/1994/who_fhe_msm_94.11_rev.1.pdf. [5] mturi aj, curtis sl. the determinants of infant and child mortality in tanzania. health policy plan. 1995 dec;10(4):384-94. review. pubmed pmid: 10154361. [6] world health organization. pregnant women and antenatal care. weekly epidemiological record. 2004 apr 2;149(79):143-44. [7] akukwe c. maternal and child health services in the twenty-first century: critical issues, challenges, and opportunities. health care women int. 2000 oct-nov;21(7):641-53. review. pubmed pmid: 11813771. [8] akukwe c, nowell ah. essential strategies for achieving durable population-based maternal and child health services. j r soc promot health. 1999 mar;119(1):42-9. pubmed pmid: 10327815. [9] patton gc, coffey c, sawyer sm, viner rm, haller dm, bose k, vos t, ferguson j, mathers cd. global patterns of mortality in young people: a systematic analysis of population health data. lancet. 2009 sep 12;374(9693):881-92. pubmed pmid: 19748397. [10] mctavish s, moore s, harper s, lynch j. national female literacy, individual socioeconomic status, and maternal health care use in sub-saharan africa. soc sci med. 2010 dec;71(11):1958-63. epub 2010 sep 29. pubmed pmid: 20980089. [11] banta d. what is the efficacy/effectiveness of antenatal care and the financial and organizational implications? copenhagen: who regional office for europe (health evidence network report; 2003 dec. [cited 2011 mar 18]. available from: http://www.euro.who.int/document/e82996.pdf. [12] hill z, kirkwood b, edmond k. family and community practices that promote child survival, growth and development. geneva: world health organization; 2004. 133 p. [13] kwast be. reduction of maternal and perinatal mortality in rural and peri-urban settings: what works? eur j obstet gynecol reprod biol. 1996 oct;69(1):47-53. review. pubmed pmid: 8909956. http://ojphi.org/ http://www.who.int/mediacentre/factsheets/fs290/en/ http://whqlibdoc.who.int/hq/1994/who_fhe_msm_94.11_rev.1.pdf http://www.ncbi.nlm.nih.gov/pubmed/10154361 http://www.ncbi.nlm.nih.gov/pubmed/11813771 http://www.ncbi.nlm.nih.gov/pubmed/10327815 http://www.ncbi.nlm.nih.gov/pubmed/10327815 http://www.ncbi.nlm.nih.gov/pubmed/19748397 http://www.ncbi.nlm.nih.gov/pubmed/20980089 http://www.euro.who.int/document/e82996.pdf http://www.whqlibdoc.who.int/publications/2004/9241591501.pdf http://www.whqlibdoc.who.int/publications/2004/9241591501.pdf http://www.ncbi.nlm.nih.gov/pubmed/8909956 http://www.ncbi.nlm.nih.gov/pubmed/8909956 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 40 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [14] kwast be. quality of care in reproductive health programmes: monitoring and evaluation of quality improvement. midwifery. 1998 dec;14(4):199-206. review. pubmed pmid: 10076314. [15] bhutta za, chopra m, axelson h, berman p, boerma t, bryce j, bustreo f, cavagnero e, cometto g, daelmans b, de francisco a, fogstad h, gupta n, laski l, lawn j, maliqi b, mason e, pitt c, requejo j, starrs a, victora cg, wardlaw t. countdown to 2015 decade report (2000-10): taking stock of maternal, newborn, and child survival. lancet. 2010 jun 5;375(9730):2032-44. review. erratum in: lancet. 2010 sep 4;376(9743):772. pubmed pmid: 20569843. [16] bhutta za, darmstadt gl, hasan bs, haws ra. community-based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence. pediatrics. 2005 feb;115(2 suppl):519-617. review. pubmed pmid: 15866863. [17] chopra m, daviaud e, pattinson r, fonn s, lawn je. saving the lives of south africa's mothers, babies, and children: can the health system deliver? lancet. 2009 sep 5;374(9692):835-46. epub 2009 aug 24. review. pubmed pmid: 19709729. [18] lawn j, kerber k, editors. opportunities for africa's newborns. cape town: the partnership for maternal, newborn & child health; 2006. 246 p. [19] walley jd, mcdonald m. integration of mother and child health services in ethiopia. trop doct. 1991 jan;21(1):32-5. pubmed pmid: 1998221. [20] bhuyan kk. health promotion through self-care and community participation: elements of a proposed programme in the developing countries. bmc public health. 2004 apr 16;4:11. review. pubmed pmid: 15086956; pubmed central pmcid: pmc419355. [21] world health organization, department of child and adolescent health development. highlights: child and adolescent health and development progress report 2000-2001. geneva: who press; 2002. 86 p. [22] wolfe, mw. mother and child: a multi-determinant model for maternal and infant health outcomes in urban, low-income communities and the effectiveness of prenatal care and other interventions. j public & int aff [internet]. 2006 spring [cited 2011 mar 18];179(169). available from: http://ssrn.com/abstract=979683. [23] kumar v, datta n. home-based mothers' health records. world health forum. 1988;9(1):107-10. pubmed pmid: 3254189. [24] shah pm, selwyn bj, shah k, kumar v. evaluation of the home-based maternal record: a who collaborative study. bull world health organ. 1993;71(5):535-48. pubmed pmid: 8261557; pubmed central pmcid: pmc2393478. [25] world health organization, child health and development maternal and child health and family planning. physical growth and psychosocial development of children: monitoring and interventions, protocol iii, design and evaluation of the child’s home-based record. geneva: world health organization; 1992. 40 p. [26] world health organization. home-based maternal records: guidelines for development, adaptation and evaluation. geneva: world health organization; 1994. 85p. http://ojphi.org/ http://www.ncbi.nlm.nih.gov/pubmed/10076314 http://www.ncbi.nlm.nih.gov/pubmed/10076314 http://www.ncbi.nlm.nih.gov/pubmed/20569843 http://www.ncbi.nlm.nih.gov/pubmed/20569843 http://www.ncbi.nlm.nih.gov/pubmed/15866863 http://www.ncbi.nlm.nih.gov/pubmed/19709729 http://www.ncbi.nlm.nih.gov/pubmed/1998221 http://www.ncbi.nlm.nih.gov/pubmed/15086956 http://ssrn.com/abstract=979683 http://www.ncbi.nlm.nih.gov/pubmed/3254189 http://www.ncbi.nlm.nih.gov/pubmed/8261557 http://www.ncbi.nlm.nih.gov/pubmed/8261557 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 41 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [27] aidstar-one. mother-infant health cards [internet]. washington, dc: usaid [updated unknown; cited 2011 mar 18]. available from: http://www.aidstarone.com/focus_areas/pmtct/resources/mother_to_child_health_cards. [28] kenya in bid to stem child deaths. daily nation [internet]. 2010 mar 1 [cited 2011 mar 18]. available from: http://www.nation.co.ke/news/-/1056/871194/-/vr4yoy//&ct=ga&cd=l7zsxv9hoio&usg=afqjcnhllmjmc1qdckcj8qbnik0vroqkqq [29] wambui s. kenya mover to curb child mortality. capital news [internet]. 2010 apr 23 [cited 2011 mar 18]. available from: http://www.capitalfm.co.ke/news/kenyanews/kenyamoves-to-curb-child-mortality-8222.html [30] maisori ct. launch of mother-child booklet 2010 apr 29 [cited 2011 mar 18]. in: giz health sector programme in kenya: home [internet]. nairobi: giz health sector programme in kenya c2006-2011. [about 1 post]. available from: http://www.gtzkenyahealth.com/blog3/?p=3859. [31] maternal & child health booklet [internet]. ministry of health government of kenya; [cited 2011 mar 18]. available from: http://www.aidskenya.org/public_site/webroot/cache/article/file/maternal__child.pdf. [32] schlosser r, wendt o, bhavnani s, nail-chiwetalu b. use of information-seeking strategies for developing systematic reviews and engaging in evidence-based practice: the application of traditional and comprehensive pearl growing. a review. int j lang & commun disord. 2006 sep/oct;41(5):567-82. [33] booth, a. unpacking your literature search toolbox: on search styles and tactics. health info libr j. 2008 dec;25(4):313-7. pubmed pmid:19076679. [34] fairer-wessels fa. basic community information needs of urban black women in mamelodi, pretoria, south africa. s afr j libr inf sci. 1990;58(4):359-69. [35] ngimwa p, ocholla dn, ojiambo j. media accessibility and utilization by kenyan rural women. int inf & lib rev. 1997 mar;29(1):45-66. [36] lugina hi, christensson k, massawe s, nystrom l, lindmark g. change in maternal concerns during the 6 weeks postpartum period: a study of primaparous mothers in dar es salaam, tanzania. j midwifery womens health. 2001 jul-aug;46(4):248-57. pubmed pmid: 11603640. [37] lugina hi, nyström l, christensson k, lindmark g. assessing mothers' concerns in the postpartum period: methodological issues. j adv nurs. 2004 nov;48(3):279-90. pubmed pmid: 15488042. [38] mooko np. the information behaviors of rural women in botswana. lib & inf sci res. 2005 winter;27(1):115-27. [39] mooko, np. a study of the family information needs and information seeking behaviors of rural women in botswana [dissertation]. [pittsburgh]: university of pittsburgh; 2002. 217 p. [40] ertem io, atay g, dogan dg, bayhan a, bingoler be, gok cg, ozbas s, haznedaroglu d, isikli s. mothers' knowledge of young child development in a developing country. child care health dev. 2007 nov;33(6):728-37. pubmed pmid: 17944782. http://ojphi.org/ http://www.aidstar-one.com/focus_areas/pmtct/resources/mother_to_child_health_cards http://www.aidstar-one.com/focus_areas/pmtct/resources/mother_to_child_health_cards http://www.nation.co.ke/news/-/1056/871194/-/vr4yoy/-/&ct=ga&cd=l7zsxv9hoio&usg=afqjcnhllmjmc1qdckcj8qbnik0vroqkqq http://www.nation.co.ke/news/-/1056/871194/-/vr4yoy/-/&ct=ga&cd=l7zsxv9hoio&usg=afqjcnhllmjmc1qdckcj8qbnik0vroqkqq http://www.capitalfm.co.ke/news/kenyanews/kenya-moves-to-curb-child-mortality-8222.html http://www.capitalfm.co.ke/news/kenyanews/kenya-moves-to-curb-child-mortality-8222.html http://www.gtzkenyahealth.com/blog3/?p=3859 http://www.aidskenya.org/public_site/webroot/cache/article/file/maternal__child.pdf http://www.ncbi.nlm.nih.gov/pubmed/19076679 http://www.ncbi.nlm.nih.gov/pubmed/11603640 http://www.ncbi.nlm.nih.gov/pubmed/11603640 http://www.ncbi.nlm.nih.gov/pubmed/15488042 http://www.ncbi.nlm.nih.gov/pubmed/15488042 http://www.ncbi.nlm.nih.gov/pubmed/17944782 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 42 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [41] bankole a, biddlecom a, guiella g, singh s, zulu e. sexual behavior, knowledge and information sources of very young adolescents in four sub-saharan african countries. afr j reprod health. 2007 dec;11(3):28-43. pubmed pmid: 18458739; pubmed central pmcid: pmc2367131. [42] green jm, coupland va, kitzinger jv. expectations, experiences, and psychological outcomes of childbirth: a prospective study of 825 women. birth. 1990 mar;17(1):15-24. pubmed pmid: 2346576. [43] baker lm, wilson fl, nordstrom ck, legwand c. mothers' knowledge and information needs relating to childhood immunizations. issues compr pediatr nurs. 2007 jan-jun;30(12):39-53. pubmed pmid: 17613141. [44] smith sk, dixon a, trevena l, nutbeam d, mccaffery kj. exploring patient involvement in healthcare decision making across different education and functional health literacy groups. soc sci med. 2009 dec;69(12):1805-12. epub 2009 oct 19. pubmed pmid: 19846245. [45] shieh c, mays r, mcdaniel a, yu j. health literacy and its association with the use of information sources and with barriers to information seeking in clinic-based pregnant women. health care women int. 2009 nov;30(11):971-88. pubmed pmid: 19809901. [46] shieh c, mcdaniel a, ke i. information-seeking and its predictors in low-income pregnant women. j midwifery womens health. 2009 sep-oct;54(5):364-72. pubmed pmid: 19720337. [47] shieh c, broome me, stump te. factors associated with health information-seeking in low-income pregnant women. women health. 2010 jul;50(5):426-42. pubmed pmid: 20853218. [48] hartfield vj. an ante-natal record card for use in developing countries. trop doct. 1973 oct;3(4):171-3. pubmed pmid: 4745121. [49] dissevelt ag, kornman jj, vogel lc. an antenatal record for identification of high risk cases by axliliary midwives at rural health centres. trop geogr med. 1976 sep;28(3):2515. pubmed pmid: 1006796. [50] sims p. ante-natal card for developing countries. trop doct. 1978 jul;8(3):137-40. pubmed pmid: 675805. [51] shah kp, shah pm. the mother's card: a simplified aid for primary health workers. who chron. 1981 feb;35(2):51-3. pubmed pmid: 7222640. [52] chabot ht, eggens kh. antenatal card for illiterate traditional birth attendants. trop doct. 1986 apr;16(2):75-8. pubmed pmid: 3765084. [53] poulton em. organisation of mch services in developing regions. 3: records. j trop pediatr afr child health. 1966 dec;12(3):80-3. pubmed pmid: 5299730. [54] essex bj, everett vj. use of an action-orientated record for antenatal screening. trop doct. 1977 jul;7(3):134-8. pubmed pmid: 302047. http://ojphi.org/ http://www.ncbi.nlm.nih.gov/pubmed/18458739 http://www.ncbi.nlm.nih.gov/pubmed/2346576 http://www.ncbi.nlm.nih.gov/pubmed/17613141 http://www.ncbi.nlm.nih/pubmed/19846245 http://www.ncbi.nlm.nih/pubmed/19846245 http://www.ncbi.nlm.nih.gov/pubmed/19809901 http://www.ncbi.nlm.nih.gov/pubmed/19720337 http://www.ncbi.nlm.nih.gov/pubmed/19720337 http://www.ncbi.nlm.nih.gov/pubmed/20853218 http://www.ncbi.nlm.nih.gov/pubmed/20853218 http://www.ncbi.nlm.nih.gov/pubmed/4745121 http://www.ncbi.nlm.nih.gov/pubmed/1006796 http://www.ncbi.nlm.nih.gov/pubmed/675805 http://www.ncbi.nlm.nih.gov/pubmed/7222640 http://www.ncbi.nlm.nih.gov/pubmed/3765084 http://www.ncbi.nlm.nih.gov/pubmed/5299730 http://www.ncbi.nlm.nih.gov/pubmed/302047 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 43 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [55] alisjahbana a, widjaya j, sukadi a. a method of reporting and identifying high risk infants for traditional birth attendants. j trop pediatr. 1984 feb;30(1):17-22. pubmed pmid: 6737538. [56] kennedy i, ritter h. antenatal records: do they help us? a new record for watching fetal growth. trop doct. 1984 jul;14(3):130-2. pubmed pmid: 6464177. [57] moidu k, singh ak, boström k, chowdhury s, trell e, wigertz o, kjessler b. towards an essential data set: applicability in the domain of maternal health services. methods inf med. 1992 sep;31(3):182-92. pubmed pmid: 1406332. [58] phelan st. the prenatal medical record: purpose, organization and the debate of print versus electronic. obstet gynecol clin north am. 2008 sep;35(3):355-68, vii. review. pubmed pmid: 18760224. [59] nakamura y. maternal and child health handbook in japan. jpn med assoc j [internet]. 2010 [cited 2011 mar 18];53(4):259-65. available from: http://www.med.or.jp/english/journal/pdf/2010_04/259_265.pdf. [60] kusumayati a, nakamura y. increased utilization of maternal health services by mothers using the maternal and child health handbook in indonesia. kokusai hoken iryo (j int health) [internet]. 2007 [cited 2011 mar 18];22(3):143-51. available from: http://www.jstage.jst.go.jp/article/jaih/22/3/22_143/_article. [61] harrison d, heese hd, harker h, mann md. an assessment of the 'road-to-health' card based on perceptions of clinic staff and mothers. s afr med j. 1998 nov;88(11):1424-8. pubmed pmid: 9861949. [62] mahomed k, mason e, warndorf t. home-based mother's record: operational feasibility, understanding and usage in a rural community in zimbabwe. trop doct. 2000 jul;30(3):155-9. pubmed pmid: 10902474. [63] tarwa c, de villiers fpr. the use of the road to health card in monitoring child health. s afr fam pract. 2007 jan-feb [cited 2011 mar 18];49(1):15-15d. available from: http://www.safpj.co.za/index.php/safpj/article/viewfile/486/637 [64] draper j, field s, thomas h, hare mj. should women carry their antenatal records? br med j (clin res ed). 1986 mar 1;292(6520):603. pubmed pmid: 3081189; pubmed central pmcid: pmc1339577. [65] elbourne d, richardson m, chalmers i, waterhouse i, holt e. the newbury maternity care study: a randomized controlled trial to assess a policy of women holding their own obstetric records. br j obstet gynaecol. 1987 jul;94(7):612-9. pubmed pmid: 3304403. [66] lovell a, zander li, james ce, foot s, swan av, reynolds a. the st. thomas's hospital maternity case notes study: a randomised controlled trial to assess the effects of giving expectant mothers their own maternity case notes. paediatr perinat epidemiol. 1987 apr;1(1):57-66. pubmed pmid: 3506191. [67] saffin k, macfarlane a. how well are parent held records kept and completed? br j gen pract. 1991 jun;41(347):249-51. pubmed pmid: 1931204; pubmed central pmcid: pmc1371589. http://ojphi.org/ http://www.ncbi.nlm.nih.gov/pubmed/6737538 http://www.ncbi.nlm.nih.gov/pubmed/6737538 http://www.ncbi.nlm.nih.gov/pubmed/6464177 http://www.ncbi.nlm.nih.gov/pubmed/1406332 http://www.ncbi.nlm.nih.gov/pubmed/18760224 http://www.med.or.jp/english/journal/pdf/2010_04/259_265.pdf http://www.jstage.jst.go.jp/article/jaih/22/3/22_143/_article http://www.ncbi.nlm.nih.gov/pubmed/9861949 http://www.ncbi.nlm.nih.gov/pubmed/10902474 http://www.safpj.co.za/index.php/safpj/article/viewfile/486/637 http://www.ncbi.nlm.nih.gov/pubmed/3081189 http://www.ncbi.nlm.nih.gov/pubmed/3304403 http://www.ncbi.nlm.nih.gov/pubmed/3506191 http://www.ncbi.nlm.nih.gov/pubmed/1931204 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 44 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [68] charles r. an evaluation of parent-held child health records. health visit. 1994 aug;67(8):270-2. pubmed pmid: 7960831. [69] jeffs d, nossar v, bailey f, smith w, chey t. retention and use of personal health records: a population-based study. j paediatr child health. 1994 jun;30(3):248-52. pubmed pmid: 8074911. [70] webster j, forbes k, foster s, thomas i, griffin a, timms h. sharing antenatal care: client satisfaction and use of the 'patient-held record'. aust n z j obstet gynaecol. 1996 feb;36(1):11-4. pubmed pmid: 8775241. [71] homer cs, davis gk, everitt ls. the introduction of a woman-held record into a hospital antenatal clinic: the bring your own records study. aust n z j obstet gynaecol. 1999 feb;39(1):54-7. pubmed pmid: 10099751. [72] phipps h. carrying their own medical records: the perspective of pregnant women. aust n z j obstet gynaecol. 2001 nov;41(4):398-401. pubmed pmid: 11787912. [73] usha kiran ts, jayawickrama ns. hand-held maternity records: are they an added burden? j eval clin pract. 2002 aug;8(3):349-52. pubmed pmid: 12164982. [74] shaw e, howard m, chan d, waters h, kaczorowski j, price d, zazulak j. access to webbased personalized antenatal health records for pregnant women: a randomized controlled trial. j obstet gynaecol can. 2008 jan;30(1):38-43. pubmed pmid: 18198066. [75] clendon j, dignam d. child health and development record book: tool for relationship building between nurse and mother. j adv nurs. 2010 may;66(5):968-77. epub 2010 mar 22. pubmed pmid: 20337798. [76] brown hc, smith hj. giving women their own case notes to carry during pregnancy. cochrane database syst rev. 2004;(2):cd002856. review. pubmed pmid: 15106181. [77] bjerkeli grøvdal l, grimsmo a, ivar lund nilsen t. parent-held child health records do not improve care: a randomized controlled trial in norway. scand j prim health care. 2006 sep;24(3):186-90. pubmed pmid: 16923629. [78] giglio r, spears b, rumpf d, eddy n. encouraging behavior changes by use of client-held health records. med care. 1978 sep;16(9):757-64. pubmed pmid: 682710. [79] liaw st, radford aj, maddocks i. the impact of a computer generated patient held health record. aust fam physician. 1998 jan;27 suppl 1:s39-43. pubmed pmid: 9503735. [80] jerdén l, weinehall l. does a patient-held health record give rise to lifestyle changes? a study in clinical practice. fam pract. 2004 dec;21(6):651-3. epub 2004 oct 1. pubmed pmid: 15465882. [81] dickey ll. promoting preventive care with patient-held minirecords: a review. patient educ couns. 1993 jan;20(1):37-47. review. pubmed pmid: 8474946. [82] lecouturier j, crack l, mannix k, hall rh, bond s. evaluation of a patient-held record for patients with cancer. eur j cancer care (engl). 2002 jun;11(2):114-21. pubmed pmid: 12099947. [83] williams jg, cheung wy, chetwynd n, cohen dr, el-sharkawi s, finlay i, lervy b, longo m, malinovszky k. pragmatic randomised trial to evaluate the use of patient held http://ojphi.org/ http://www.ncbi.nlm.nih.gov/pubmed/7960831 http://www.ncbi.nlm.nih.gov/pubmed/8074911 http://www.ncbi.nlm.nih.gov/pubmed/8775241 http://www.ncbi.nlm.nih.gov/pubmed/10099751 http://www.ncbi.nlm.nih.gov/pubmed/11787912 http://www.ncbi.nlm.nih.gov/pubmed/12164982 http://www.ncbi.nlm.nih.gov/pubmed/18198066 http://www.ncbi.nlm.nih.gov/pubmed/20337798 http://www.ncbi.nlm.nih.gov/pubmed/15106181 http://www.ncbi.nlm.nih.gov/pubmed/16923629 http://www.ncbi.nlm.nih.gov/pubmed/682710 http://www.ncbi.nlm.nih.gov/pubmed/9503735 http://www.ncbi.nlm.nih.gov/pubmed/15465882 http://www.ncbi.nlm.nih.gov/pubmed/15465882 http://www.ncbi.nlm.nih.gov/pubmed/8474946 http://www.ncbi.nlm.nih.gov/pubmed/12099947 http://www.ncbi.nlm.nih.gov/pubmed/12099947 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 45 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 records for the continuing care of patients with cancer. qual health care. 2001 sep;10(3):159-65. pubmed pmid: 11533423; pubmed central pmcid: pmc1743428. [84] drury m, yudkin p, harcourt j, fitzpatrick r, jones l, alcock c, minton m. patients with cancer holding their own records: a randomised controlled trial. br j gen pract. 2000 feb;50(451):105-10. pubmed pmid: 10750206; pubmed central pmcid: pmc1313626. [85] cornbleet ma, campbell p, murray s, stevenson m, bond s; joint working party of the scottish partnership agency for palliative and cancer care and national council for hospice and specialist palliative care services. patient-held records in cancer and palliative care: a randomized, prospective trial. palliat med. 2002 may;16(3):205-12. pubmed pmid: 12046996. [86] lester h, allan t, wilson s, jowett s, roberts l. a cluster randomised controlled trial of patient-held medical records for people with schizophrenia receiving shared care. br j gen pract. 2003 mar;53(488):197-203. [87] gysels m, richardson a, higginson ij. does the patient-held record improve continuity and related outcomes in cancer care: a systematic review. health expect. 2007 mar;10(1):75-91. review. pubmed pmid: 17324196. [88] ko h, turner t, jones c, hill c. patient-held medical records for patients with chronic disease: a systematic review. qual saf health care. 2010 oct;19(5):e41. epub 2010 may 28. review. pubmed pmid: 20511601. [89] kumar v, walia i. pictorial maternal and neonatal records for illiterate traditional birth attendants. int j gynaecol obstet. 1981 aug;19(4):281-4. pubmed pmid: 6172300. [90] watson ds. use of "at risk" antenatal score card by aboriginal health workers in arnhem land. trop doct. 1984 jul;14(3):133-5. pubmed pmid: 6464178. [91] abraham s, joseph a. evaluation of a home based antenatal card. j trop pediatr. 1985 feb;31(1):39-42. pubmed pmid: 3981694. [92] abraham s, joshi s, kumar v, patwary a, pratinidhi a, saxena vb, maitra k, singh kk, saxena nc, saxena bn. indian experience of home based mothers card: icmr task force study. indian j pediatr. 1991 nov-dec;58(6):795-804. pubmed pmid: 1818874. [93] daly ad, nxumalo mp, biellik rj. missed opportunities for vaccination in health facilities in swaziland. s afr med j. 2003 aug;93(8):606-10. pubmed pmid: 14531121. [94] corrigall j, coetzee d, cameron n. is the western cape at risk of an outbreak of preventable childhood diseases? lessons from an evaluation of routine immunisation coverage. s afr med j. 2008 jan;98(1):41-5. pubmed pmid: 18270640. [95] osaki k, hattori t, kosen s, singgih b. investment in home-based maternal, newborn and child health records improves immunization coverage in indonesia. trans r soc trop med hyg. 2009 aug;103(8):846-8. epub 2009 apr 16. pubmed pmid: 19375141. [96] mukanga do, kiguli s. factors affecting the retention and use of child health cards in a slum community in kampala, uganda, 2005. matern child health j. 2006 nov;10(6):54552. pubmed pmid: 16850275. http://ojphi.org/ http://www.ncbi.nlm.nih.gov/pubmed/11533423 http://www.ncbi.nlm.nih.gov/pubmed/10750206 http://www.ncbi.nlm.nih.gov/pubmed/12046996 http://www.ncbi.nlm.nih.gov/pubmed/17324196 http://www.ncbi.nlm.nih.gov/pubmed/20511601 http://www.ncbi.nlm.nih.gov/pubmed/6172300 http://www.ncbi.nlm.nih.gov/pubmed/6464178 http://www.ncbi.nlm.nih.gov/pubmed/3981694 http://www.ncbi.nlm.nih.gov/pubmed/1818874 http://www.ncbi.nlm.nih.gov/pubmed/14531121 http://www.ncbi.nlm.nih.gov/pubmed/18270640 http://www.ncbi.nlm.nih.gov/pubmed/19375141 http://www.ncbi.nlm.nih.gov/pubmed/16850275 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 46 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [97] chabot ht, rutten am. use of antenatal cards for literate health personnel and illiterate traditional birth attendants: an overview. trop doct. 1990 jan;20(1):21-4. pubmed pmid: 2305476. [98] kumar r. streamlined records benefit maternal and child health care. world health forum. 1993;14(3):305-7. pubmed pmid: 8397747. [99] goldman n, pebley ar. health cards, maternal reports and the measurement of immunization coverage: the example of guatemala. soc sci med. 1994 apr;38(8):1075-89. pubmed pmid: 8042056. [100] nuwaha f, kabwongyera e, mulindwa g, barenzi e. national immunisation days for polio eradication in uganda: did immunisation cards increase coverage? east afr med j. 2000 feb;77(2):66-70. pubmed pmid: 10774077. [101] mcelligott jt, darden pm. are patient-held vaccination records associated with improved vaccination coverage rates? pediatrics. 2010 mar;125(3):e467-72. epub 2010 feb 15. pubmed pmid: 20156897. [102] macfarlane a, saffin k. do general practitioners and health visitors like 'parent held' child health records? br j gen pract. 1990 mar;40(332):106-8. pubmed pmid: 2112011; pubmed central pmcid: pmc1371075. [103] toohill j, soong b, meldrum m. risk management considerations and the pregnancy handheld record. an audit of the return rate of the pregnancy handheld record. women birth. 2006 dec;19(4):113-6. epub 2006 sep 22. pubmed pmid: 16996332. [104] wilkinson sa, miller yd. improving health behaviours during pregnancy: a new direction for the pregnancy handheld record. aust n z j obstet gynaecol. 2007 dec;47(6):464-7. pubmed pmid: 17991110. [105] atkin pa, finnegan tp, ogle sj, shenfield gm. are medication record cards useful? med j aust. 1995 mar 20;162(6):300-1. pubmed pmid: 7715491. [106] dijkstra rf, braspenning jc, huijsmans z, akkermans rp, van ballegooie e, ten have p, casparie t, grol rp. introduction of diabetes passports involving both patients and professionals to improve hospital outpatient diabetes care. diabetes res clin pract. 2005 may;68(2):126-34. epub 2005 jan 11. pubmed pmid: 15860240. [107] dale o, hagen kb. despite technical problems personal digital assistants outperform pen and paper when collecting patient diary data. j clin epidemiol. 2007 jan;60(1):8-17. epub 2006 aug 30. review. pubmed pmid: 17161749 [108] thomas sm, overhage jm, warvel j, mcdonald cj. a comparison of a printed patient summary document with its electronic equivalent: early results. proc amia symp. 2001:701-5. pubmed pmid: 11825276; pubmed central pmcid: pmc2243457. [109] blake h. innovation in practice: mobile phone technology in patient care. br j community nurs. 2008 apr;13(4):160, 162-5. review. pubmed pmid: 18595303. [110] walker i, sigouin c, sek j, almonte t, carruthers j, chan a, pai m, heddle n. comparing hand-held computers and paper diaries for haemophilia home therapy: a randomized trial. haemophilia. 2004 nov;10(6):698-704. pubmed pmid: 15569164. http://ojphi.org/ http://www.ncbi.nlm.nih.gov/pubmed/2305476 http://www.ncbi.nlm.nih.gov/pubmed/2305476 http://www.ncbi.nlm.nih.gov/pubmed/8397747 http://www.ncbi.nlm.nih.gov/pubmed/8042056 http://www.ncbi.nlm.nih.gov/pubmed/10774077 http://www.ncbi.nlm.nih.gov/pubmed/20156897 http://www.ncbi.nlm.nih.gov/pubmed/2112011 http://www.ncbi.nlm.nih.gov/pubmed/16996332 http://www.ncbi.nlm.nih.gov/pubmed/17991110 http://www.ncbi.nlm.nih.gov/pubmed/7715491 http://www.ncbi.nlm.nih.gov/pubmed/15860240 http://www.ncbi.nlm.nih.gov/pubmed/17161749 http://www.ncbi.nlm.nih.gov/pubmed/11825276 http://www.ncbi.nlm.nih.gov/pubmed/18595303 http://www.ncbi.nlm.nih.gov/pubmed/15569164 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 47 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [111] wu rc, straus se. evidence for handheld electronic medical records in improving care: a systematic review. bmc med inform decis mak. 2006 jun 20;6:26. review. pubmed pmid: 16787539; pubmed central pmcid: pmc1538581. [112] diero l, rotich jk, bii j, mamlin bw, einterz rm, kalamai iz, tierney wm. a computer-based medical record system and personal digital assistants to assess and follow patients with respiratory tract infections visiting a rural kenyan health centre. bmc med inform decis mak. 2006 apr 10;6:21. pubmed pmid: 16606466; pubmed central pmcid: pmc1482308 [113] anantraman v, mikkelsen t, khilnani r, kumar vs, pentland a, ohno-machado l. open source handheld-based emr for paramedics working in rural areas. proc amia symp. 2002:12-6. pubmed pmid: 12463777; pubmed central pmcid: pmc2244537. [114] bernabe-ortiz a, curioso wh, gonzales ma, evangelista w, castagnetto jm, carcamo cp, hughes jp, garcia pj, garnett gp, holmes kk. handheld computers for selfadministered sensitive data collection: a comparative study in peru. bmc med inform decis mak. 2008 mar 19;8:11. pubmed pmid: 18366687; pubmed central pmcid: pmc2323371. [115] mukund bahadur kc, murray pj. cell phone short messaging service (sms) for hiv/aids in south africa: a literature review. stud health technol inform. 2010;160(pt 1):530-4. review. pubmed pmid: 20841743. [116] koskinen e, salminen j. a customizable mobile tool for supporting health behavior interventions. conf proc ieee eng med biol soc. 2007:5908-11. pubmed pmid: 18003358. [117] bielli e, carminati f, la capra s, lina m, brunelli c, tamburini m. a wireless health outcomes monitoring system (whoms): development and field testing with cancer patients using mobile phones. bmc med inform decis mak. 2004 jun 15;4:7. pubmed pmid: 15196308; pubmed central pmcid: pmc441394. [118] kundu s, mukherjee j, majumdar ak, majumdar b, sekhar ray s. algorithms and heuristics for efficient medical information display in pda. comput biol med. 2007 sep;37(9):1272-82. epub 2007 jan 12. pubmed pmid: 17222816. [119] overdyk fj, haynes gr, arvanitis pj. patient-borne memory device facilitates "point of care" data access. md comput. 1999 may-jun;16(3):60-3. pubmed pmid: 10439604. [120] blake h. mobile phone technology in chronic disease management. nurs stand. 2008 nov 26-dec 2;23(12):43-6. review. pubmed pmid: 19093357. [121] katz dl, nordwall b. novel interactive cell-phone technology for health enhancement. j diabetes sci technol. 2008 jan;2(1):147-53. pubmed pmid: 19885191; pubmed central pmcid: pmc2769699. [122] pena v, watson aj, kvedar jc, grant rw. mobile phone technology for children with type 1 and type 2 diabetes: a parent survey. j diabetes sci technol. 2009 nov 1;3(6):14819. pubmed pmid: 20144404; pubmed central pmcid: pmc2787050. [123] inter-american development bank. project profile: mobile citizens – solutions at hand. maternal health information: getting connected for better maternal and child health http://ojphi.org/ http://www.ncbi.nlm.nih.gov/pubmed/16787539 http://www.ncbi.nlm.nih.gov/pubmed/16787539 http://www.ncbi.nlm.nih.gov/pubmed/16606466 http://www.ncbi.nlm.nih.gov/pubmed/12463777 http://www.ncbi.nlm.nih.gov/pubmed/18366687 http://www.ncbi.nlm.nih.gov/pubmed/20841743 http://www.ncbi.nlm.nih.gov/pubmed/18003358 http://www.ncbi.nlm.nih.gov/pubmed/18003358 http://www.ncbi.nlm.nih.gov/pubmed/15196308 http://www.ncbi.nlm.nih.gov/pubmed/15196308 http://www.ncbi.nlm.nih.gov/pubmed/17222816 http://www.ncbi.nlm.nih.gov/pubmed/10439604 http://www.ncbi.nlm.nih.gov/pubmed/19093357 http://www.ncbi.nlm.nih.gov/pubmed/19885191 http://www.ncbi.nlm.nih.gov/pubmed/20144404 patient-held maternal and/or child health records: meeting the information needs of patients and healthcare providers in developing countries? 48 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 2, 2011 [internet]. [place unknown]: inter-american development bank; c2009 [cited 2011 apr 20]. available from: http://www.mobilecitizen.bidinnovacion.org/en/projects.html. [124] martínez a, villarroel v, seoane j, del pozo f. analysis of information and communication needs in rural primary health care in developing countries. ieee trans inf technol biomed. 2005 mar;9(1):66-72. pubmed pmid: 15787009 [125] patrick k, griswold wg, raab f, intille ss. health and the mobile phone. am j prev med. 2008 aug;35(2):177-81. epub 2008 jun 12. pubmed pmid: 18550322; pubmed central pmcid: pmc2527290. http://ojphi.org/ http://www.mobilecitizen.bidinnovacion.org/en/projects.html http://www.ncbi.nlm.nih.gov/pubmed/15787009 http://www.ncbi.nlm.nih.gov/pubmed/18550322 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts an algorithm that identifies coronary and heart failure events in the electronic health record jawali jaranilla*1, thomas e. kottke1 and courtney j. baechler2 1health partners institute for education and research, minneapolis, mn, usa; 2university of minnesota, minneapolis, mn, usa objective the objective of this project was to identify criteria that accurately categorize acute coronary and heart failure events exclusively with electronic health record data so that the medical record can be used for surveillance without manual record review. introduction surveillance to track the incidence, prevalence and treatment of disease is a fundamental task of public health. the advent of universal health care coverage in the united states and electronic health records could make the medical record a valuable disease surveillance tool. this can only happen, however, if the necessary data can be extracted from the medical record without manual review. methods we serially compared 3 different computer algorithms to manual record review. the first two algorithms relied on icd9cm codes, troponin levels, ecg data and echocardiographic data. the 3rd algorithm relied on a very detailed coding system, imo statements, troponin levels and echocardiographic data. results cohen’s kappa for the initial algorithm was 0.47 (95%ci 0.410.54). cohen’s kappa was 0.61 (95%ci 0.55-0.68) for the second algorithm. cohen’s kappa for the third algorithm was 0.99 (95%ci 0.98-1.00). conclusions we conclude that electronic medical record data are sufficient to categorize coronary heart disease and heart failure events without manual record review. however, only moderate agreement with medical record review can be achieved when the classification is based on 4-digit icd9cm codes because icd9cm 410.9 includes myocardial infarction with st elevation (stemi) and myocardial infarction without st elevation (nstemi). nearly perfect agreement can be achieved using imo statements, a more detailed coding system that tracks to icd9, icd10 and snomed-ct. imo statements are available in many electronic medical record systems. keywords validity; surveillance; coronary artery disease; heart failure; electronic medical record acknowledgments funding provided by the following: the healthpartners research foundation (a partnership grant to tek); the heart disease and stroke prevention unit at the minnesota department of health from a capacity building cooperative agreement grant from the centers for disease control and prevention cdc) 5u50dp000721-04; and, nih training grant t32 hl69764 (supporting cjb). *jawali jaranilla e-mail: jjaranil@jhsph.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e159, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluation of the pyrrolizidine alkaloid induced liver disease (paild) active surveillance system in tigray, ethiopia cindy chiu*1, danielle buttke1, girmay welde2, richard luce3, asfaw debela4, amsalu bitew5, tesfaye bayleyegn1, sara vagi1, matthew murphy1, daniel woldemichael2, teshale seboxa6, gidey g. libanos7, zeyeda beyene7, yohannes g. hawaria7, daddi jimma4, israel tareke8, danielle rentz1 and colleen martin1 1centers for disease control and prevention, atlanta, ga, usa; 2tigray agriculture bureau, tigray, ethiopia; 3centers for disease control and prevention, addis ababa, ethiopia; 4ethiopian health and nutrition research institute, addis ababa, ethiopia; 5suhul hospital, tigray, ethiopia; 6addis ababa university, addis ababa, ethiopia; 7tigray regional health bureau, tigray, ethiopia; 8world health organization, addis ababa, ethiopia objective to describe the results of the evaluation of the paild active surveillance system and lessons learned for similar surveillance efforts in a resource-limited setting. introduction a liver disease of unknown etiology, called unknown liver disease (uld) by the community, was first identified in 2002 in tigray; a rugged, semi-arid, mountainous region that is considered one of the most drought-prone and food insecure regions of ethiopia. uld is a chronic condition characterized by epigastric pain, abdominal distention, ascites, emaciation, and hepato/splenomegaly. in 2005, the ethiopian health and nutritional research institute was assigned by the ethiopia ministry of health to assist the tigray regional health bureau and oversee the disease investigation. in 2008, centers for disease control and prevention (cdc) assisted the ethiopian team and jointly developed the surveillance tools. the surveillance system was implemented in 2009 with the objectives to determine the magnitude and distribution of the disease; identify disease trends; detect cases to provide them with clinical care; and inform health officials and funding bodies for resource allocation. after several investigations, a local plant containing a particular type of pyrrolizidine alkaloid (pa) toxin that contaminated local foodstuffs was identified as the etiologic agent, and uld was renamed paild in 2011. methods from 20 september to 1 october 2011, we conducted site visits, held semi-structured interviews with 20 staff members, reviewed reporting materials, and summarized the information flow including data collection, reporting, analysis, and dissemination. results this surveillance system was implemented in 13 rural, resourcelimited districts in the nw, central and western zones. the system identified a total of 1033 cases, including 314 deaths, as of september 2011; guided medication distribution to the health facilities; served as a registry for patient follow up; and provided decision-makers with information needed to allocate resources. a large-scale training was conducted in 2010; however, high staff turnover and a lack of backup surveillance staff at each site suggested that additional training may be needed. due to the absence of a diagnostic test, the case definition was very simple to enable frontline staff in the communities and at the health posts/centers to identify disease cases. these individuals travelled long distances by foot to deliver paper surveillance forms to the district health offices. a surveillance team placed in the nw zonal office collected missing reports from the health facilities given limited transportation; however they have left since this evaluation. information from the surveillance system was shared with partner agencies at the national level every 3 to 6 months; however, this information was not shared with frontline staff. conclusions the paild active surveillance system met its objectives as originally defined. evaluation of this unique surveillance system for a chronic disease with unknown cause in a resource-limited setting provides several lessons that can inform similar surveillance efforts. ongoing logistical challenges (e.g., shortage of paper forms, lack of transportation, and long distances between locations) complicated data collection and reporting. while electronic reporting may have helped overcome some of these difficulties, it was not feasible in this setting. frontline staff identified cases in the community so that they could receive treatment; these key staff can be further incentivized by receiving regular training and surveillance reports. ongoing support will be critical to overcome these unique challenges to ensure continual disease monitoring as interventions to disrupt pa exposure are implemented in the community. keywords evaluation; pyrrolizidine alkaloid induced liver disease; active surveillance system; ethiopia *cindy chiu e-mail: vic2@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e167, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts use of syndromic data to determine oral health visit burden on emergency departments howard burkom*1, sherry burrer1, laurie barker3, valerie robison3, peter hicks1 and amy ising2 1cdc, osels, public health surveillance program office, atlanta, ga, usa; 2university of north carolina department of emergency medicine, chapel hill, nc, usa; 3cdc, nccdphp, div. of oral health, atlanta, ga, usa objective the objective was to use syndromic surveillance data from the north carolina disease event tracking and epidemiologic collection tool ncdetect and from biosense to quantify the burden on north carolina (nc) emergency departments of oral health-related visits more appropriate for care in a dental office (ed). calculations were sought in terms of the medicaid-covered visit rate relative to the medicaid-eligible population by age group and by county. introduction concern over oral health-related ed visits stems from the increasing number of unemployed and uninsured, the cost burden of these visits, and the unavailability of indicated dental care in eds [1]. of particular interest to nc state public health planners are medicaid-covered visits. syndromic data in biosurveillance systems offer a means to quantify these visits overall and by county and age group. methods using biosense data received from ncdetect, 60.8 million records from 12.9 million ed visits were collected, covering all nc visits for state fiscal years (sfy) 2008-2010. roughly 4% of visits were dropped because of patient residence zip codes missing or outside nc. a careful multi-step procedure involving both dentist consultants and data analysis was used to derive classification criteria for visits whose main reason was a nontraumatic oral health problem [2]. this procedure yielded 243,970 visits by ~174,600 patients based on hospital-specific patient identifiers. nontraumatic oral health-related visits were collected in a study set with added fields for method of payment, patient residence county, and age group. based on previous studies, consultant preferences, and nc medicaid eligibility guidelines, selected age groups were 0-14, 15-19, 20-29, 30-49, 50+ years. stratified counts of medicaid-eligibles were obtained from the nc dental director by study year. using these tables and the ed visit study set, rates of nontraumatic oral health-related medicaid visits per 10,000 eligibles were tabulated by county and age group for each study year. demographics of multiple-visit patients were also studied. results rates of ed oral health-related visits were substantially higher for young adults than for other age groups. from statewide rates in table 1, this age factor was consistent across study years. county-level rates showed the same age pattern to varying degrees. detailed analysis showed problem areas, with rates in 21 of 100 counties exceeding 60 per 10,000 eligibles for the 20-29 year age group. plots and tables complemented understanding of the ed oral health visit burden by age and county. the state total ed burden for oral health problems was ~2% (0.2% 9.7% by county). conclusions judicious use of syndromic data with external information, such as the detailed medicaid denominators and the method of payment codes for each visit above, can give quantified estimates for policyrelated public health issues. in the current study, the derived oral health visit rates gave numerical detail to concerns about the use of nc eds for nontraumatic oral health problems by low-income persons affected by the economic recession. results also show rate variation by county and can be combined with access-to-care data to inform planning of effective local measures to improve access to dental services and thus reduce the ed visit burden. table 1. nc statewide oral health medicaid visits to emergency departments per 10,000 eligibles keywords emergency department; chief complaint; biosense; oral health; ncdetect acknowledgments mark casey, north carolina dental director for medicaid eligibility and care provider data; chris okunseri, marquette university for case definition advice; lana deyneka of the north carolina department of health and human services for consultation; dennis falls of ncdetect for method of payment information. references 1. shortridge, e. and moore, j. 2010. “use of emergency departments for conditions related to poor oral health care.” final report. washington, dc: office of rural health policy. august 2010. 2. burrer s, burkom h, okunseri c, barker l, robison v, nontraumatic oral health classification developed from syndromic data, abstract, international society of disease surveillance conference 2012. *howard burkom e-mail: howard.burkom@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e57, 2013 ojphi-06-e20.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 104 (page number not for citation purposes) isds 2013 conference abstracts biosurveillance data stream framework: a novel approach to characterization and evaluation kristen margevicius*, eric generous, kirsten taylor-mccabe, mac brown, w. brent daniel, lauren castro, andrea hengartner and alina deshpande los alamos national laboratory, los alamos, nm, usa � �� �� �� � � �� �� �� � objective ��������� � �� � ��� � ������ ���� ���� ���� ��� ������������� ������ ��� ����� ���� ����� � ��� � ������������ ������ ����� �������� �������� � �������� ����� � ����� introduction ����� ���� � ���� ���� ���������� �� ������������� ����� �������� ��������������� ������������������������������� ��� ����������� � �� � � ������� ������� ��� ����� � !�� � ������������� �� ������������ ���������� ������ ��� � ��� � ����� �������������������������� ����� � �����" � ��� � ���� ����������������� � �������������������� ����� ���� �� ��� ����� ������������ ����� ����������������������������� ��� � ���� ���� ������ ��������� ����� ���� ��� ��� �� ������������ �������� ��� ����� �������� �� ���������� � ��� � ��� ���� ��������� �� � ���� ��� ������ ���������� �� ����� ������� �� ������ ������ ������������ ����� ���� ������������������� �� � ������������������ ���� �������� ���� �������� ����� ���������������� methods #���������� ���� ��� ����� ����� ���� �� ���������� �� ��� ��� � � � �� � ��������$ ������ ����� �������� ����� ����� �����%��������������� ���� �������� ����� ������������� ���� � ���� ������� ����� �������� ������� ��������������� ��������� ������� �� ���� ����� ����� ����� ���� � ����� ������� ��� � ���&���� � ��� � �' � �� $(�)%� ���� ��� ���� �������������� ����� �������������������(�)� ���� � �������� �' � ��������������� ��� ��� � ���� ������ ����������������� ������� �� ����� ����� ���*�(������ ������ ������ ���������� ���� ��� ��� �� ����� ��� � ��������������������" � ��� � ����� ������������� ��� ��������� ��� ������� ��� �� ��������� ��� � �������+������� ��� �� �������� ������������������� � ��� � ����� ���������� ������������ � ���� ���� ������ ��������������� �������������� ������������� � � �� � ��� ���� ������ ������������������� ������� ���� �������������� �������������� ��� ������� �� ���� � ��� � ��� ����������� ����� ���� results +����� ������������� � ��� � ��� ���� �����������$�������� �%�� (�'����� � � �� � � � �� � �� � ���� ���� �� �� ������������ ,� �� ������ �� ��� ���" � �(� � ��� ���� ������ ��� �������������������� � � ������� ���������������������� ������������������ �������� ����� ����� +���� ����� ���������� ����������� ��� � ��� � �� ��� � ��� � ����� � �����+���������������� � �� ������ ������-� ����� ��������������������� � �������� � ��� � ����������������� ���������� ����� ����� � ��� � ��� �� �������������'������ ������ ����������������� ����� ������ ������� �� �� �������������������� ����� ��� ��� �� ���������� ��������� � ������ �� �������� ������ ��� � ��� � ����� �� ���� ������������ ������� ����� ������������ ����� ����� ���� ��������������������(�)� ���������������������� �� ��� ������������� ����� ������������ +�� �� �� ������������� �������� � ��� � ������������� ���������� ��������� � ��� � ������� � ���� ������������� �� ���������� ��������� � � ������� ��� ������� ���� � � ��� �� ����� ��� �������������� ������� � � ���� ������������������� ���� �������������� � �� ���� ��� � � � ���$����.���� ����� ����/���� ���"� ���� ���./"%����� ���� ���� ���� � ��������� � ���� ����������������� �������� ����� ������������� 0 ���112���������� � ������343�� � ��� � ����� �� ��� ���� ���� �� ������" � ��� � ��� � ���������15������ �16�� ���� ������ ���������� ���� ������������������������������������������������� � ��� � ��� �� ��� �� �� �� ��� ��� ���������7�� ����� �� ����� � ��� ����+�� ����./"������������������ � ������������� �� ���� ������ ������ ��� ����������������� ����� � ��� � ����� ������ �������� �������� ������ ��� � ����� conclusions ���� ������ ����� ��� ���� .���� ����� ���� " � � (� � �� 0 ��� �� �� ��������� ��� ������� ���� ������ ��������� � ���������� � � �� � ��������� � ������ ������������� ������ ����� ��������� ��������� � ���� �� ����� � ��� � �������������'������������ ��������� ������ ������ ���� �������������������� �������� �������������������� �� �� ��� ��������������� ��������� �� ���� �� ����� �������������� �������� � ����������� ��� � ��� � ����� ������������������ ����� ������ ����� � ����� ��������������� ��� ����� ���� ���������� ������� ����� ��� � ������ keywords � � ��� � �8������ ����� ���8���������������� �� acknowledgments ����� �&��������� � �����������9����� �� ���.������� ��������������� "� ���� ���:�����(������� ��������������;������$:(�;%��"��������� � �� /���������+������$"�/+%� *kristen margevicius e-mail: kmargevicius@lanl.gov� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e20, 2014 building the foundations of an informatics agenda for global health—2011 workshop report building the foundations of an informatics agenda for global health 2011 workshop report 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 building the foundations of an informatics agenda for global health 2011 workshop report muzna mirza 1 , mary kratz 2 , donna medeiros 3a , jamie pina 3b , janise richards 1 , xiaohui zhang 4 , hamish fraser 5 , christopher bailey 6 , ramesh krishnamurthy 6 1 centers for disease control and prevention, atlanta, ga, usa 2 university of michigan, ann arbor, mi, usa 3a (former) rti international, research triangle park, nc, usa; (current) futures group, washington, dc, usa 3b rti international, research triangle park, nc, usa 4 scientific technologies corporation, tucson, az, usa 5 harvard university, cambridge, ma, usa 6 world health organization, geneva, switzerland abstract strengthening the capacity of public health systems to protect and promote the health of the global population continues to be essential in an increasingly connected world. informatics practices and principles can play an important role for improving global health response capacity. a critical step is to develop an informatics agenda for global health so that efforts can be prioritized and important global health issues addressed. with the aim of building a foundation for this agenda, the authors developed a workshop to examine the evidence in this domain, recognize the gaps, and document evidence-based recommendations. on 21 august 2011, at the 2011 public health informatics conference in atlanta, ga, usa, a four-hour interactive workshop was conducted with 85 participants from 15 countries representing governmental organizations, private sector companies, academia, and non-governmental organizations. the workshop discussion followed an agenda of a plenary session planning and agenda setting and four tracks: policy and governance; knowledge management, collaborative networks and global partnerships; capacity building; and globally reusable resources: metrics, tools, processes, templates, and digital assets. track discussions examined the evidence base and the participants’ experience to gather information about the current status, compelling and potential benefits, challenges, barriers, and gaps for global health informatics as well as document opportunities and recommendations. this report provides a summary of the discussions and key recommendations as a first step towards building an informatics agenda for global health. attention to the identified topics http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 and issues is expected to lead to measurable improvements in health equity, health outcomes, and impacts on population health. we propose the workshop report be used as a foundation for the development of the full agenda and a detailed roadmap for global health informatics activities based on further contribution from key stakeholders. the global health informatics agenda and roadmap can provide guidance to countries for developing and enhancing their individual and regional agendas. key words: global public health informatics, agenda, policy, capacity development, collaboration introduction in today’s globalized world, where diseases, conditions or events affecting health transcend national boundaries,(1) the need to strengthen the capacity (2) to protect and promote the health of the global population continues to be important. the application of information and communication technology (ict) for health i.e. ehealth (3) is an important aspect of the delivery of global health.(4) leveraging informatics best practices and principles is essential for improving global health response capacity through implementation of ehealth.(5) a critical step towards strengthening this capacity is developing an informatics agenda for global health which can provide guidance to countries for developing and enhancing their national and regional country agendas. the 2005 58th world health assembly ehealth resolution (wha58.28) urges member states “to consider drawing up a long-term strategic plan for developing and implementing ehealth services.”(6) since then, two significant collaborative activities have addressed wha58.28: a. initial high-level efforts at bellagio 2008 led to an “ehealth call to action”(7); and b. mahidol global health information forum 2010 convened informatics experts,(2) resulting in a “call to action” agreeing to general ehealth principles. in an effort to continue to address wha58.28, the authors identified the need for an activity to examine the evidence for use of informatics for global health, recognize the gaps in evidence, and provide evidence-based recommendations as the next logical steps toward building a comprehensive informatics agenda for global health. to ensure perspective diversity and stakeholder involvement, a group of 85 invited experts representing a diverse stakeholder community gathered for the global health workshop at the 2011 public health informatics conference on 21 august 2011 in atlanta, ga, usa. the workshop goals were to begin building an informatics agenda addressing current and future global health challenges,(8) and to support the implementation of ehealth initiatives using informatics principles and practices to improve global health. workshop objectives included: 1. engage health informatics and global health experts to discuss the foundational elements of an informatics agenda for global health. 2. identify informatics evidence-base, best practices and principles to draft key elements of the agenda for global health. http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 3. define global health challenges and priorities, and formulate next steps to move towards the full agenda. the full scope of topics from the 2008 bellagio call for action (7) was reorganized into tracks according to topic affiliation to structure expert dialog on key areas described below. plenary session: planning and agenda setting: the plenary session engaged all participants together to discuss global health challenges that implementation of informatics scientific principles and practice can address, thus setting the stage for the subsequent track discussions. track 1 policy and governance: supportive policy and governance development and implementation are essential to successful implementation of ehealth and thus are important to include in informatics agendas.(9) political authorities, policymakers and stakeholders must take collective action for consensus-based use of institutional resources. formation of councils, creation of ehealth policy frameworks, toolkits and a trained workforce are key elements for policy and governance development and implementation. track 2 knowledge management, collaboration, and global partnerships: collaboration is a fundamental success factor for global health—it supports the use of “the resources, knowledge, and experience of diverse societies to address health challenges throughout the world.”(1) the implementation of relevant informatics best practices support collaboration and knowledge management among the ehealth stakeholders. multisectoral collaboration has been recommended by wha58.28 for addressing global health needs.(6) track 3 capacity building: capacity building efforts occur at the individual, institutional, and societal levels. these efforts support the development of in-country expertise to build infrastructure and harness resources, bolstering capabilities and economic value. the scope of this track encompassed informatics training and education in diverse domains including leadership and management. participants also discussed mechanisms to support country-level initiatives and foster country ownership to ensure sustainability of ehealth efforts, and capacity building in data management. track 4 globally reusable resources: metrics, tools, processes, templates and digital assets: ehealth resources that can be shared and reused via various models facilitate the development of scalable and sustainable infrastructures and institutes essential to the effectiveness and productivity of a health enterprise. examples of successful models include: metrics – health metrics network (hmn) framework; tools – free and open source software, virtual data toolkit http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 (vdt); processes – monitoring and evaluation processes; templates – for standard operating procedures; and digital assets – digital libraries.(10) methods invitations to participate in the workshop were sent to public health informatics and global health experts identified through purposive sampling (i.e., snowball sampling). workshop registration link was also provided on the conference website for open enrollment. registrants were asked to indicate their track of interest during online registration. the registration lists were reviewed and shortlisted because of limited seating capacity; best efforts were made to include stakeholders from all represented groups in each track. each track was supported by the track lead and invited experts. to facilitate discussion some of the larger tracks broke into smaller discussion groups. each track used the following predefined discussion format: 1. set the stage: why is this area of informatics important? 2. current status: where are we today? 3. compelling benefits: what are the established and potential outcomes? 4. challenges, barriers and gaps: what are the hurdles on the way towards our goals? 5. opportunities and recommendations: what are the opportunities and where do we aim to be tomorrow? results the workshop was organized as an ancillary meeting in the pre-conference session of the 2011 public health informatics conference, atlanta, ga, usa. there were 85 participants from 15 countries representing governmental organizations, private sector companies, academia, and nongovernmental organizations. the following summaries—organized by track and following the dialog format methodology—represent the key outcomes of the workshop discussions. additional information is provided in exhibits. plenary session: planning and agenda setting the workshop co-chairs led the plenary track and recognized that regular reassessment of the rapidly changing state of ict, ehealth initiatives, and informatics practices and principles can provide evidence to develop and continually strengthen a robust informatics agenda, implementation of which could move the ehealth activities forward more systematically. however, to set an agenda, a clear definition of global health is essential. global health as a term is found in literature but there is no consensus on definition. (1, 11-13) the scope of global health as defined by koplan et al (1) was used as a reference to define the scope of this agendasetting workshop. health information systems development to provide quality data and information to make better health-related decisions is crucial for supporting global health goals. enterprise architecture is a methodology that assists in systematically organizing the multiple elements in the design and development of health information systems and ict infrastructure to meet global health equity and health impact goals. global health equity requires focusing on both domestic health disparities and cross-border concerns. (1) health impact assessment requires well-defined http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 measures to assess population health improvement due to the implementation of ict through ehealth initiatives using informatics practices and principles to guide implementation. a fuller discussion of how global health enterprise architecture could be developed, implemented, and evaluated was identified to be beyond the scope of this workshop and recommended as the topic of a future workshop. track 1: policy and governance set the stage many nations have some form of ehealth policy, but commonality remains limited. policymakers face numerous challenges in thinking beyond local representation needs in a global context.(3) the potential of ehealth to meet both national and global health objectives has not been fully developed and requires strong leadership.(14) current status global ehealth policy and governance development and implementation is an iterative and ongoing process. enormous advances have been made in medical knowledge, technology, and training of health care professionals, but ehealth application based on standard methodologies is significantly lagging because of policy gaps. policymakers generally react to specific problems and crises leading to gaps in the overall national and global polices. nations around the world struggle to effect ehealth policy models that can build on evidence-based practices and measures. some sporadic, focused efforts have occurred before and since the meeting in bellagio 2008 (exhibit 1). however, to date, no global, sustained collaborative effort has been established towards developing global ehealth policy and governance guidelines. collaborative investments in global policy and governance development are needed to usher in the promise of ehealth.(15) exhibit 1. key recent ehealth policy and agenda setting activities the 2005 58th world health assembly ehealth resolution (wha58.28) urged member states to consider developing long-term strategic plans for developing and implementing ehealth services. the world health organization (who) global observatory for ehealth (goe) supports these goals by providing member states with strategic information and guidance on effective practices, policies, and standards in ehealth. a leadership series forums on health information systems (his) have convened in several who regions. b the health metrics network (hmn), established in 2005, is the first global partnership dedicated to strengthening national health information systems. hmn operates as a network of global, regional, and country partners. among hmn’s initiatives, a target of having accurate, real-time data from the vital registration systems in all countries by 2020 was proposed in september 2011 by thomas frieden, director of the u.s. centers for disease control and prevention. c the “making the ehealth connection” effort, led by the rockefeller foundation, in coordination with internationally recognized conveners in the fields of global health, international development, and information and communications technology (ict), resulted in the 2008 bellagio meeting. d http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 the mhealth alliance (mha) was formed in 2009 to advance mobile health through policy, research, advocacy, and support for the development of interoperable solutions and sustainable deployment models. e the international organization for standardization (iso) ehealth standards (in draft) contains ehealth architecture and capacity-building standards. public health task force, a working group hosted by the iso/technical committee (tc) 215 “joint initiative on standards development organization (sdo) global health informatics standardization”, drafts the standards. f european countries have made substantial progress toward modern ehealth infrastructures and implementations, thereby leading the rest of the world. the european union (eu), comprising 27 countries of differing economic levels that share a vision of health care developed in the 2004 ehealth action plan, called on member states to develop an ehealth roadmap to 2010. annually, the eu convenes ehealth conferences, meetings of ministers of health, and holds initiatives on interoperability, quality criteria, and lead markets. g ________________________________ a fifty-eighth world health assembly, resolution twenty eight, 16-24 may 2005, geneva, switzerland. wha58-28 on ehealth. [accessed 9 october 2011]; available from: http://apps.who.int/gb/ebwha/pdf_files/wha58/wha58_28-en.pdf and http://www.docstoc.com/docs/101599959/resolution-wha5828-ehealth---who--world-healthorganization b his forum. webpage on the internet. [accessed 21 february 2012] available from: http://hisforum.org/ c health metrics network (hmn). webpage on the internet. [accessed 21 february 2012] available from: http://www.who.int/healthmetrics/en/ d khoja s, durrani h, fahim a. scope of policy issues for e-health: results from a structured review [internet]. new york: rockefeller foundation [accessed 15 jan 2010]; available from: http://www.ehealth-connection.org/files/confmaterials/scope%20of%20policy%20issues%20for%20ehealth_0.pdf e mobilizing innovation for global health, un foundation. mhealth alliance. [accessed 20 october 2011]; available from http://www.mhealthalliance.org/ f the joint initiative on sdo global health informatics standardization. global health informatics standards. [accessed 20 october 2011]; available from: http://www.global-e-health-standards.org/ g mars m, scott r. global e-health policy: a work in progress. health aff (millwood) 2010;29(2):23945. compelling benefits health in all countries could benefit from the development of a coordinated global ehealth policy to support national legislation development for effective use of ehealth resources. challenges, barriers and gaps a unified voice for ehealth policy development is absent.(16) often, ministries of health do not fully understand the benefits that ehealth can bring to national public health programs. numerous fragmented pilot efforts continue to reinvent the wheel and consume resources. http://apps.who.int/gb/ebwha/pdf_files/wha58/wha58_28-en.pdf http://www.docstoc.com/docs/101599959/resolution-wha5828-ehealth---who--world-health-organization http://www.docstoc.com/docs/101599959/resolution-wha5828-ehealth---who--world-health-organization http://hisforum.org/ http://www.who.int/healthmetrics/en/ http://www.ehealth-connection.org/files/conf-materials/scope%20of%20policy%20issues%20for%20ehealth_0.pdf http://www.ehealth-connection.org/files/conf-materials/scope%20of%20policy%20issues%20for%20ehealth_0.pdf http://www.mhealthalliance.org/ http://www.global-e-health-standards.org/ http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 informatics tools to guide on-the-ground baseline assessment, implementation, scaling, and evaluation of information systems are needed, using substantial resources already in existence such as the hmn tools.(9) exhibit 2 summarizes the track 1 discussion. (exhibit 2) exhibit 2. summary of policy and governance track compelling benefits informed, globally coordinated decision making and thus enhanced global health response capacity. improved availability of quality information to national policy developers. improved health care service quality through ehealth implementation based on informatics standards and best practices. challenges, barriers and gaps lack of a globally coordinated effort for ehealth strategic planning. lack of evidence-based practices for ehealth policy and governance guidelines. limited and inadequate funding for development of global ehealth policy and governance strategic roadmap. limited experience in technology and resistance to change. changing national priorities and cultural challenges are not generally addressed in existing ehealth policy and governance material. recommendations engage stakeholders, including ministry of health (moh) officials, and provide information and resources for assessments and evaluations. develop national and global research programs to identify information needs, recognize barriers to access, and translate and use information to evaluate the impact of information and knowledge-sharing interventions on health outcomes. target donor funding and involvement, encourage adoption of open source platforms and of technologies focused on sustainability. align donor funding to reduce global health fragmentation, harmonize reporting requirements, and consolidate reporting structures. train local public health leadership in informatics, thus building capacity at country level. provide tools and resources to encourage governments to adopt a culture of ehealth interoperability based on open standards. encourage moh-appointed leadership for health information technology to establish countrylevel agendas, and obtain stakeholder buy-in and funding. encourage governments to adopt a culture of ehealth interoperability in health system strengthening programs, and strengthen the capacity to access and use health information as evidence to improve decision making. encourage adoption of regional and cross-border information sharing, knowledge management and collaboration, and creation of virtual communities of practice and centers of excellence that lead to expanded knowledge in the use of new and existing technologies. http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 opportunities and recommendations bringing organizations together, building consensus, and developing a roadmap are complex propositions that present great opportunities and challenges and require momentum.(17) a logical next step would be to build a collaborative environment for convening sustainable effort. track participants developed a 5-year national ehealth framework approach that could be used to lay the foundations for national policy development efforts (exhibit 3). exhibit 3. recommendation: country-level 5-year ehealth policy framework 1–3 year country-specific action items a. engage and inform stakeholders at all levels about the need and value for timely and reliable health information. b. assess country health profile, and document donor health information activity profile. c. conduct inventory of legislation to identify policy gaps at all levels. d. establish policy-based coordination mechanism to institutionalize and operationalize health information use for evidence-based decision making. e. throughout, hold meetings and disseminate information gathered through a collaborative community. 3–5 year country-specific action items a. finance health information systems capacity development at all levels. b. establish governing mechanism to implement appropriate standards-based information systems at all levels through standards development organizations (sdos). c. harmonize and align legislation to comply with national obligations for reporting of health data to support global public health needs. track 2: knowledge management, collaboration and global partnerships setting the stage collaboration among diverse stakeholders to share knowledge and expertise is a fundamental factor for public health practice. knowledge management systems are critical tools to bring people, processes, information, and technology together. a 2005 association of state and territorial health officials (astho) report provided perspectives for public health knowledge management,(18) and liebowitz has summarized selected international efforts in this domain.(19) current status overall, there is an increasing trend in the application of knowledge management and collaboration principles and methods to the health enterprise to develop sustainable global partnerships. however, there have been few implementations that are inclusive of low-resource settings. some ehealth specialties, such as mobile health (mhealth),(20) extensively leverage collaborative methodologies and knowledge management practices; however, ehealth in general http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 has not yet widely adopted these informatics best practices. additionally, training and practice in these domains are still quite limited in the global health setting. compelling benefits the participants highlighted existing knowledge management systems and collaborative methodologies, and recognized that web 2.0 applications and mobile technologies (21) have provided tremendous opportunities for knowledge sharing and collaboration. experience has demonstrated that collaborating to share data, information and knowledge empowers us to increase transparency, improve research and education, support better decision making, help deliver care, and save lives.(22) challenges, barriers and gaps many public health information systems are functionally isolated from other systems because they are not based on informatics standards nor on sustainment models. planning generally lacks collaboration and systems thinking; therefore, systems are not interoperable. additionally, collaborative projects across multiple governments and organizations face policy and sociocultural barriers, in addition to lack of resources and skills, that are often bigger than technical challenges. opportunities and recommendations resources need to be better coordinated at all levels to optimize efficiency and efficacy. collaborative projects should be encouraged to use international informatics standards and promote free access to international standards, thus enabling interoperability, while sharing innovation and best practices. formation of a working group to facilitate the development of the domain of global public health knowledge management and collaboration is necessary to identify strategic goals, align priorities among stakeholders, create an inventory of standards, and promote sharing of best practices. (exhibit 4) http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 exhibit 4: summary of knowledge management, collaboration and global partnerships track compelling benefits increased transparency improved health research, education and care delivery enhanced public health essential practice challenges, barriers and gaps information systems planning efforts lack collaboration and use of standards. information system implementation lacks use of standards and best practices. data collection systems generally do not collect metadata and spatial information and thus collaboration for using the data is challenging. insufficient funding for education and workforce training in the domain. policy, sociocultural, and technical barriers in collaboration agreements. disease specific funding streams are generally not conducive to collaboration across diseases and funding streams. recommendations better coordinate the funding sources: include knowledge management and collaboration in the planning phases of projects. leverage international standards: promote free access to international standards to improve interoperability and thus promote collaboration around using data. form a working group to build a collaborative community: the goals of the working group could be to identify strategic goals and priorities for global health informatics, and create an inventory of informatics standards, knowledge and best practices. track 3: capacity building set the stage strengthening informatics workforce capacity positively affects public health by promoting quality of care and increasing the ability to monitor health trends. sustainable changes require long-term planning and investment. global health spending currently exhibits a trend toward long-term programmatic commitment, which suggests that a stable level of funding for global health initiatives will exist in the long-term. (23) sustainable national informatics capacity will ensure continuity of informatics applications, which will promote continued improved outcomes when external funding eventually expires. current status externally funded development initiatives provide support to resource-constrained countries, offering immediate relief for pressing health concerns. however, such efforts rarely include a strategic plan for creating long-term change in local information management infrastructure and workforce capacity. http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 compelling benefits a robust informatics workforce supports local care delivery and public health practice. a strong local workforce provides independence from external funding and supports expertise for information management activities over the long term. challenges, barriers and gaps local informatics capacity building is limited in several ways. stakeholders with varying priorities provide funding to health-promoting programs.(24) however, strategies to develop incountry information management capacity are not typically a focus of these programs. when informatics is included as a fundable activity in such programs, the goal is to provide local systems for the life of a project instead of developing capacity that will serve future efforts as well. lack of informatics training is a major barrier to ict implementation in resourceconstrained environments.(25) training programs, when present as part of an externally-funded program, are often focused on the use of a specific system for a finite purpose instead of basic computer literacy and information management principles. as a result, learners are rushed into information system usage without acquiring foundational skills. as there are few professional paths for health informaticians in these settings, there is little incentive for local technology talent to seek work in public health programs. opportunities and recommendations the participants advocated in-country health programs should create actionable plans to bolster local informatics capacity. externally funded programs should contribute to local capacity while concurrently fulfilling their health intervention missions. a neutral entity must develop a framework for local informatics capacity building. the framework should build off of existing efforts to standardize capacity development,(15) and focus on sharing core training materials and curricula. adherence to standards for capacity development should be an integral part of every public health intervention and include building off of local innovations to support viable economic development, fostering government ownership to enable ehealth benefits and knowledge transfer through portable accreditation programs. (exhibit 5) http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 exhibit 5: summary of capacity building track compelling benefits improved quality of care improved communication sustainability challenges, barriers and gaps training deficits are not well studied and documented strategic plans are dedicated to health issues, and often do not have informatics components commercial markets do not exist for global health informatics products recommendations to develop a framework for capacity building that includes the following components: building off of local innovation: capacity building initiatives should support the creation of viable commercial markets for health informatics products, to support sustainability. foster local government ownership and buy-in for informatics training initiatives: ministries of health should be provided with tangible examples of the value of informatics for implementation of ehealth when advocating for ehealth. portable accreditation: to allow workers to easily apply their knowledge to new environments. track 4: globally reusable resources: metrics, tools, processes, templates, and digital assets set the stage in today’s resource-constrained global economy, globally reusable resources are useful for developing sustainable ehealth infrastructures and systems essential to a health enterprise. their use allows the development of community solutions, professional networks for data sharing, and open access to health information.(26, 27) existing evidence indicates that dedication to developing globally reusable resources can lead to production of agile, efficient health systems, which can result in timely and more accurate responses to public health events.(28-30) current status many standards-based free and open source software (foss) products, especially m-health applications, are available online.(31) a number of these open source applications have achieved worldwide impact—notably, the linux operating system and the apache web server, which dominate the market. however, foss business models vary and may not always work across a global context. additionally, total cost of ownership involving foss components must account for implementation and operational support as well as software update costs. the incentive model for private-sector companies must be modified to support reuse of ict resources. capacity building of the workforce should not be underestimated; standardized tools find success primarily through user adoption. most mainstream public health information systems are not yet http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 developed with reusable resources. in the health care domain, vista — based on open source components — has the largest market share for comprehensive hospital information systems in the us,(14) and has been adopted in many international settings as well. compelling benefits the primary benefits are cost reduction and interoperability by avoiding duplication of effort and following standards. quality of generated information can improve if organizations use welltested and validated components for systems development. cloud computing (software as a service – saas model) provides significant cost savings.(32) the main savings are in the resources required to support ict infrastructure; shared services have cost and workflow efficiencies when resources are reused across a virtual organization.(28) challenges, barriers and gaps challenges to building the global health infrastructure using standards-based reusable resources such as tools and services are threefold. first, basic computer science skills required to shift from the current model of siloed or isolated databases into distributed systems are limited. second, there is a lack of policy and legal regulations in support of open access to information across the global context.(33) finally, standardizing medical concept definitions is time consuming, making data inconsistent between systems and slowing the process of developing systems. (34) translating the benefits of reusable resources to resource-poor environments can be challenging. reliable internet access is rare in rural areas, though mobile phone networks are improving. many projects need to manage local databases, though some are able to synchronize the data to a central server when connectivity is available. electricity availability represents a challenge in many rural and even urban locations, but solar power, low-power devices and better batteries, and generators offer options to address outages. opportunities and recommendations policy and governance development for the oversight of shared reusable resources is a global responsibility.(35) certification for quality assurance may ensure high system quality and interoperability, leading to improved user satisfaction while easing data management burdens. readiness assessments that measure economic and human capacity realities should be required. assistance could be provided by a global community of practice to low-resource countries as required, to ensure that response and remediation to global health challenges are addressed quickly and efficiently. the next logical step is to make health informatics standards, especially those developed using public funds, available in the public domain. (exhibit 6) http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 exhibit 6: summary of globally reusable resources track compelling benefits productivity is optimized and increased (reduced labor burden and cost efficiency). implementing standards-based systems facilitates sharing of information, knowledge and infrastructure. standardization and use of shared methods reduce duplication of effort. open systems can be more effectively evaluated over time. better decision making for sustainable health system operations and infrastructure. standards-based design of tools provides greater flexibility while reducing costs. equal proactivity is the notion that equity in tools and infrastructure increases global workforce capacity and efficiency. horizontalization of health systems expands reach of health services. a challenges, barriers and gaps data from legacy systems is generally not machine-readable and thus is not shareable seamlessly electronically among systems. open access/public access: confusion (or ambiguity) exists about standards and legality of open access to data. proprietary issues surround the customized code built out of collaborative efforts. lack of skilled workforce required to build shared tools and reusable components. user interfaces are not standardized for medical information access, thus collaborative use requires considerable training, making it challenging for users to accept a new system. recommendations ensure better policy development and governance for oversight of quality assurance and policy implementations. clearly define the most important information gaps in global health. support evidence-based evaluations of tools, services, and other reusable resources. invest in robust infrastructures with scalable resources; build on sustainable solutions. make health informatics standards available in the public domain. encourage open source software development and implementation and suitable business models to ensure high quality standards, acceptable development time, and long-term support for maintenance. promote sharing of medical content, including data dictionaries, coding standards and indicators among global stakeholders. establish a worldwide mechanism for certification and testing of globally reusable services. provide better methods for findability of shared products. evaluate total cost of operation versus initial purchase price for foss projects and attempt to improve cost efficiency. a bacharach, s., “technology convergence, market horizontalization and, voila: information fusion”, directions magazine, http://www.directionsmag.com/articles/technology-convergence-markethorizontalization-and-ivoilai-information-fus/122770, 24 january 2008 http://www.directionsmag.com/articles/technology-convergence-market-horizontalization-and-ivoilai-information-fus/122770 http://www.directionsmag.com/articles/technology-convergence-market-horizontalization-and-ivoilai-information-fus/122770 http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 limitations due to limited funding for this activity, only participants of the 2011 public health informatics conference were able to attend the workshop. thus, there was under-representation from many low-resource countries. an attempt was made to overcome this limitation by ensuring that the participants selected from the online registrants list brought a diverse experience of supporting the under-represented areas. discussion following the 2008 meeting in bellagio, gerber et al identified the need for “an international public-private sector framework for understanding and moving forward on ehealth”(15). the 2011 global health workshop was an important step towards addressing this need and bridging a gap in the global health informatics domain. the workshop discussions created a rich environment to examine the evidence base and the participants’ experience for the current status; compelling and potential benefits; challenges, barriers, and gaps; and recommendations for the key domains of informatics as applied to global health. the strength of the workshop lay in the unique blend of participants who represented 15 countries and a diverse stakeholder landscape of governmental organizations, private sector companies, academia, and non-governmental organizations. in addition to their regular jobs, the participants provide voluntary support to various informatics and ehealth technical workgroups around the world and thus also represented those collaborative virtual organizations. the participants recommended that effective policies and governance mechanisms must be in place prior to global crises response so that global health events do not overwhelm public health response capacity. the development of an infrastructure to support global health information exchange must address legal, technical, political and economic barriers. establishment of priorities to guide economic investments in informatics research and innovation should support patient care, global health goals, public access to data and knowledge sharing among countries across both international and regional boundaries. the health informatics community needs to collaboratively focus on addressing global health problems and challenges by leveraging existing infrastructure, harmonizing global policy and governance efforts, and advocating effectively.(36) for such a diverse community to coalesce and collaborate, appropriate resources must be acquired and allocated optimally to provide sustainable virtual and physical organizational support. such a global community can drive rapid development of knowledge management mechanisms and systems that facilitate the identification of global health priorities; create, manage, share, and disseminate information; and facilitate decision making for evolving global health challenges, policies and events. in resource-constrained environments, building informatics capacity allows for clinical delivery organizations and national ministries of health to continue to benefit from standards-based information management practices beyond the duration of externally-funded interventions or programs. when building informatics capacity, stakeholders must examine methods to train, http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 maintain and retain a workforce at the local level with skills to design, develop, implement and sustain the deployment of health information systems for ehealth initiatives. reusable ict resources play a critical role in support of global health.(37) primary drivers of adoption are economic because of reducing duplicate efforts; interoperability by building solutions on common technology standards;(38) developing partnerships with mutual benefits; pooling of experience and knowledge; and instituting a two-way information and knowledge flow between developed and developing countries. low-threshold access to more resources than any single health system could afford individually can facilitate country participation in the global health information exchange projects while concurrently strengthening national infrastructure.(39) many countries have developed national ehealth strategies and initiatives to enhance the implementation of ict in health. however, few have realized that developing ehealth national strategies while focusing only on the domestic needs has the potential to technically isolate their country from the rest of the world at times when there is need for relevant information sharing across borders. examples of such use cases include reporting cases of public health emergencies of international concern by complying with the 2005 international health regulations (ihrs) (40), or when their residents visit other countries and health providers in the international location need to access the visitors’ previous health information to provide care.(41) following the informatics recommendations of standards-based implementation of ehealth will ensure that countries get prepared for participation in regional and global networks in support of use cases such as global health surveillance and global access to health care, with minimal additional effort required for each emerging event. the 2011 global health workshop recommendations pave the way for establishing an overarching global informatics strategy, following which will help countries stay technically synchronized with countries outside their borders. because of the myriad of ongoing activities in the ehealth domain, individual countries would benefit from the informatics agenda for global health by acquiring guidance for developing and enhancing their individual and regional agendas. roadmap development activities on a global scale require commitment and funding support from global health funding organizations. the 2011 workshop was supported by limited funds from a few organizations; travel funds were not available for more key stakeholders to be included and thus the workshop lacked more global representation among the participants. additionally, more funding would have enabled us to develop a longer and more comprehensive plan for the workshop. the large number of participants representing a diverse stakeholder group who acquired their organizations’ support to attend the workshop clearly highlights the value of this activity. this report provides evidence that more investment in this domain is required. we anticipate that major global health donors will consider supporting the next phase of this activity. in summary, the participants highlighted the importance of developing and implementing good informatics policy and governance guidelines in support of global health. they recognized the importance of global health stakeholders to focus on transparency, equity and technological interoperability as local needs change in response to domestic and global health events. to improve knowledge management and collaboration, stakeholders highlighted the need to explore methods for identifying, collating and sharing best practices, and for the adoption of social http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 networking technologies to foster rich collaborations. local informatics workforce capacity development was recognized as a key foundation-stone for long term sustainability of ehealth initiatives. in the use and creation of health information resources, stakeholders must ensure that the products are adaptable, adoptable, and reusable by the global health community. attention to these issues can lead to measurable improvements in health equity, individual health outcomes, and positive impact on global public health. conclusion global health informatics best-practices and principles continue to support global health systems via implementation of ehealth. the workshop provided a venue to examine the evidence base and the participants’ experience to provide outcomes as summaries of the current status; compelling benefits; challenges, barriers, and gaps; and recommendations for the application of informatics scientific principles and best practices to support ehealth implementation for global health. we propose that these workshop findings be used as a foundation for the development of the full agenda and a detailed long-term roadmap for global health informatics activities. the global health informatics agenda and roadmap can potentially provide valuable guidance to countries for developing and enhancing their individual and regional agendas. corresponding author muzna mirza centers for disease control and prevention 1600 clifton road ne, atlanta, 30333, ga. email: mmirza@cdc.gov acknowledgments we applied the percent-contribution-indicated (pci) approach for the sequence of authors. we are grateful for the stimulating discussions and comments by dave ross, beatriz de faria leao, laura raney, sherrilynne fuller, lincoln moura, raymond ransom, brian robie, linda carr, seth foldy, brian agbiriogu, andrew grant, james kauivihi, patrick nguku, sam malamba, and many others who participated in the workshop. thanks indeed to august gering for excellent editorial support and to rita sembajwe and prachi mehta for logistical support for the workshop. funding the workshop was organized and sponsored by the centers for disease control and prevention, rti international, and scientific technologies corporation. mailto:mmirza@cdc.gov http://ojphi.org building the foundations of an informatics agenda for global health 2011 workshop report 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 competing interests the authors have declared that no competing interests exist. disclaimer the findings and conclusions in this report are those of the authors and do not necessarily represent the official positions of the centers for disease control and prevention (cdc), department of health and human services, usa, and the world health organization (who), switzerland. references 1. koplan jp, bond tc, merson mh, et al. 2009. towards a common definition of global health. lancet. 373(9679), 1993-95. http://dx.doi.org/10.1016/s0140-6736(09)60332-9 2. mahidol conference. call for action. 2010 [cited 2011 october 9 ]; web page]. available from: http://www.pmaconference.mahidol.ac.th/index.php? option=com_content&view=article&id=201%3acall-to-action-final&catid=966%3a2010conference&itemid=152 3. mars m, scott r. 2010. global e-health policy: a work in progress. health aff (millwood). 29(2), 239-45. http://dx.doi.org/10.1377/hlthaff.2009.0945 4. jonas s, kovner ar, knickman j. health care delivery in the united states. 9 ed. albany, new york: springer publishing; 2010. 5. castillo-salgado c. 2010. trends and directions of global public health surveillance. epidemiol rev. 32(1), 93-109. http://dx.doi.org/10.1093/epirev/mxq008 6. world health assembly. wha58-28 on ehealth fifty-eighth world health assembly, resolution twenty eight. 2005 16-24 may 2005 [cited 2011 october 9]; available from: http:// apps.who.int/gb/ebwha/pdf_files/wha58/wha58_28-en.pdf 7. bellagio meeting attendees. bellagio 2008 ehealth call for action. 2008 [cited 2011 october 9 ]; available from: http://ehealth-connection.org/content/bellagio-ehealth-call-action 8. geoff r. 2011. meeting global health challenges through operational research and management science. world health organization bulletin. 89, 683-88. http:// dx.doi.org/10.2471/blt.11.086066 9. health metrics network. guidance for the health information systems (his) strategic planning process. 2009 [cited 2011 october 21 ]; available from: http://www.who.int/ healthmetrics/en/ 10. university of michigan. global health information & resources. [cited 2011 october 21]; available from: http://guides.lib.umich.edu/globalhealth 11. fraser h, blaya j. 2010. implementing medical information systems in developing countries, what works and what doesn’t. amia annu symp proc. •••, 232-36. 12. garde s, harrison d, hovenga e. 2005. skill needs for nurses in their role as health informatics professionals: a survey in the context of global health informatics education. int j med inform. 74(11-12), 899-907. http://dx.doi.org/10.1016/j.ijmedinf.2005.07.008 13. fried lp, bentley me, buekens p, et al. 2010. global health is public health. lancet. 375, 535-37. http://dx.doi.org/10.1016/s0140-6736(10)60203-6 14. jha ak, desroches cm, campbell eg, et al. 2009. use of electronic health records in u.s. hospitals. n engl j med. (360), 1628-38. http://dx.doi.org/10.1056/nejmsa0900592 http://www.pmaconference.mahidol.ac.th/index.php?option=com_content&view=article&id=201%3acall-to-action-final&catid=966%3a2010-conference&itemid=152 http://www.pmaconference.mahidol.ac.th/index.php?option=com_content&view=article&id=201%3acall-to-action-final&catid=966%3a2010-conference&itemid=152 http://apps.who.int/gb/ebwha/pdf_files/wha58/wha58_28-en.pdf http://ehealth-connection.org/content/bellagio-ehealth-call-action http://www.who.int/healthmetrics/en/ http://guides.lib.umich.edu/globalhealth http://ojphi.org http://dx.doi.org/10.1016/s0140-6736 http://www.pmaconference.mahidol.ac.th/index.php?option=com_content&view=article&id=201%3acall-to-action-final&catid=966%3a2010-conference&itemid=1523 http://www.pmaconference.mahidol.ac.th/index.php?option=com_content&view=article&id=201%3acall-to-action-final&catid=966%3a2010-conference&itemid=1523 http://www.pmaconference.mahidol.ac.th/index.php?option=com_content&view=article&id=201%3acall-to-action-final&catid=966%3a2010-conference&itemid=1523 http://www.pmaconference.mahidol.ac.th/index.php?option=com_content&view=article&id=201%3acall-to-action-final&catid=966%3a2010-conference&itemid=1523 http://dx.doi.org/10.1377/hlthaff.2009.09454 http://dx.doi.org/10.1377/hlthaff.2009.09454 http://dx.doi.org/10.1093/epirev/mxq0086 http://dx.doi.org/10.1093/epirev/mxq0086 http://apps.who.int/gb/ebwha/pdf_files/wha58/wha58_28-en.pdf7 http://apps.who.int/gb/ebwha/pdf_files/wha58/wha58_28-en.pdf7 http://apps.who.int/gb/ebwha/pdf_files/wha58/wha58_28-en.pdf7 http://dx.doi.org/10.2471/blt.11.0860669 http://dx.doi.org/10.2471/blt.11.0860669 http://dx.doi.org/10.2471/blt.11.0860669 http://www.who.int/healthmetrics/en/10 http://www.who.int/healthmetrics/en/10 http://www.who.int/healthmetrics/en/10 http://guides.lib.umich.edu/globalhealth11 http://guides.lib.umich.edu/globalhealth11 http://dx.doi.org/10.1016/j.ijmedinf.2005.07.00813 http://dx.doi.org/10.1016/j.ijmedinf.2005.07.00813 http://dx.doi.org/10.1016/s0140-6736 building the foundations of an informatics agenda for global health 2011 workshop report 19 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 15. gerber t, olazabal v. 2010. an agenda for action on global e-health. health aff (millwood). 29(2), 233-36. http://dx.doi.org/10.1377/hlthaff.2009.0934 16. euractiv. denz: european union ehealth strategies “not connected to reality”. 5 january 2010 [cited 2011 october 21 ]; interview with martin denz, president of the european health telematics association]. available from: http://www.euractiv.com/health/denz-eu-ehealthstrategies-connected-reality/article-172170 17. khoja s, durrani h, fahim a. scope of policy issues for e-health: results from a structured review [cited 2012 january 24 ]; available from: http://www.ehealth-connection.org/files/confmaterials/scope%20of%20policy%20issues%20for%20ehealth_0.pdf 18. association of state and territorial health officers. knowledge management for public health professionals. washington, dc: association of state and territorial health officials; 2005. 19. liebowitz j, schieber r. andreadis j. knowledge management in public health: crc press 2009 20. mhealth alliance. mobilizing innovation for global health. 2011 [cited 2011 october 20 ]; available from: http://www.mhealthalliance.org/ 21. mhealth alliance. health unbound. 2011 [cited 2011 october 20 ]; available from: http:// www.healthunbound.org/ 22. institute of medicine. the us commitment to global health: recommendations for the public and private sectors. washington (dc): national academy of sciences; 2009. 23. dodd r, lane c. 2010. improving the long-term sustainability of health aid: are global health partnerships leading the way? health policy plan. 25(5), 363-71. http:// dx.doi.org/10.1093/heapol/czq014 24. mccoy d, chand s. 2009. global health funding: how much, where it comes from and where it goes. health policy plan. 24(6), 407-17. http://dx.doi.org/10.1093/heapol/czp026 25. ameh n, kene ts. 2008. computer knowledge amongst clinical year medical students in a resource poor setting. afr health sci. 8(1), 40-43. 26. foster i, kesselmann c. the grid: blueprint for a new computing infrastructure. usa: morgan kaufmann 1999. 27. chen x, duan g, & research on concepts and technologies of grid collaborative designing to supporting cross enterprise collaboration. springer; 2007. 28. foster i, kesselman c, tuecke s. 2001. the anatomy of the grid: enabling scalable virtual organizations. int j supercomput appl. •••, 15. 29. czajkowski k, fitzgerald s, foster i, kesselman c. grid information services for distributed resource sharing, 10th ieee international symposium on high performance distributed computing.; 2001: ieee press; 2001. 30. kratz m, silverstein j, dev p. healthgrid: grid technology for biomedicine integrated research team report. 2006. 31. kemp r. free/open source software (foss) – boon or burden? society for computers and law london. london: kemp little llp; 2009. 32. herbert l, erickson j. the roi of software as a service: forrester research; 2009. 33. creative commons. [cited 2011 october 21]; available from: http://creativecommons.org/ 34. morville p. ambient findability: what we find changes who we become: o’reilly publishing; 2005. 35. council of the european union. council conclusions on common values and principles in the european union health systems. official journal of the european union. 2006;c 146/01. http://www.euractiv.com/health/denz-eu-ehealth-strategies-connected-reality/article-172170 http://www.euractiv.com/health/denz-eu-ehealth-strategies-connected-reality/article-172170 http://www.ehealth-connection.org/files/conf-materials/scope%20of%20policy%20issues%20for%20ehealth_0.pdf http://www.ehealth-connection.org/files/conf-materials/scope%20of%20policy%20issues%20for%20ehealth_0.pdf http://www.ehealth-connection.org/files/conf-materials/scope%20of%20policy%20issues%20for%20ehealth_0.pdf http://www.mhealthalliance.org/ http://www.healthunbound.org/ http://creativecommons.org/ http://ojphi.org http://dx.doi.org/10.1377/hlthaff.2009.093416 http://dx.doi.org/10.1377/hlthaff.2009.093416 http://www.mhealthalliance.org/21 http://www.mhealthalliance.org/21 http://www.healthunbound.org/22 http://www.healthunbound.org/22 http://www.healthunbound.org/22 http://dx.doi.org/10.1093/heapol/czq01424 http://dx.doi.org/10.1093/heapol/czq01424 http://dx.doi.org/10.1093/heapol/czq01424 http://dx.doi.org/10.1093/heapol/czp02625 http://dx.doi.org/10.1093/heapol/czp02625 http://creativecommons.org/34 http://creativecommons.org/34 building the foundations of an informatics agenda for global health 2011 workshop report 20 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 1, 2012 36. rodrigues r. opportunities and challenges in the deployment of global e-health. int j healthcare technology and management. 2003;5(3/4/5):335-58. 37. lytras m, sakkopoulous e, ordonez de pablos p. 2009. semantic web and knowledge management for the health domain: state of the art and challenges for the seventh framework programme (fp7) of the european union (2007-2013). int j healthc technol manag. 47(1-3), 239-49. http://dx.doi.org/10.1504/ijtm.2009.024124 38. the joint initiative on sdo global health informatics standardization. global health informatics standards. [cited 2011 october 20 ]; available from: http://www.global-e-healthstandards.org/ 39. bacharach s. technology convergence, market horizontalization and, voila: information fusion. . directions magazine. 2008 january 24th 2008 40. world health organization. 2005 international health regulations. 2005 [cited 2012 february 3]; available from: http://www.who.int/ihr/en/ 41. li js, zhou ts, chu j, araki k, yoshihara h. 2011. design and development of an international clinical data exchange system: the international layer function of the dolphin project. journal of the american medical informatics association : jamia. 18(5), 683-89. http://dx.doi.org/10.1136/amiajnl-2011-000111 http://www.global-e-health-standards.org/ http://www.global-e-health-standards.org/ http://www.who.int/ihr/en/ http://ojphi.org http://dx.doi.org/10.1504/ijtm.2009.02412438 http://dx.doi.org/10.1504/ijtm.2009.02412438 a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model shahid a. choudhry 1 , jing li 1 , darcy davis 2 , cole erdmann 1 , rishi sikka 2 , bharat sutariya 1 1 cerner corporation, kansas city, 2 advocate health care, chicago abstract introduction: preventing the occurrence of hospital readmissions is needed to improve quality of care and foster population health across the care continuum. hospitals are being held accountable for improving transitions of care to avert unnecessary readmissions. advocate health care in chicago and cerner (acc) collaborated to develop all-cause, 30-day hospital readmission risk prediction models to identify patients that need interventional resources. ideally, prediction models should encompass several qualities: they should have high predictive ability; use reliable and clinically relevant data; use vigorous performance metrics to assess the models; be validated in populations where they are applied; and be scalable in heterogeneous populations. however, a systematic review of prediction models for hospital readmission risk determined that most performed poorly (average c-statistic of 0.66) and efforts to improve their performance are needed for widespread usage. methods: the acc team incorporated electronic health record data, utilized a mixed-method approach to evaluate risk factors, and externally validated their prediction models for generalizability. inclusion and exclusion criteria were applied on the patient cohort and then split for derivation and internal validation. stepwise logistic regression was performed to develop two predictive models: one for admission and one for discharge. the prediction models were assessed for discrimination ability, calibration, overall performance, and then externally validated. results: the acc admission and discharge models demonstrated modest discrimination ability during derivation, internal and external validation post-recalibration (c-statistic of 0.76 and 0.78, respectively), and reasonable model fit during external validation for utility in heterogeneous populations. conclusions: the acc admission and discharge models embody the design qualities of ideal prediction models. the acc plans to continue its partnership to further improve and develop valuable clinical models. key words: 30-day all-cause hospital readmission, readmission risk stratification tool, predictive analytics, prediction model, derivation and external validation of a prediction model, clinical decision prediction model correspondence: ali.choudhry@cerner.com copyright ©2013 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi introduction curbing the frequency and costs associated with hospital readmissions within 30 days of inpatient discharge is needed to improve the quality of health care services (1-3). hospitals are held accountable for care delivered through new payment models, with incentives for improving discharge planning and transitions of care to mitigate preventable readmissions (4, 5). consequently, hospitals must reduce readmissions to evade financial penalties by the centers for medicare & medicaid services (cms) under the hospital readmissions reduction program (hrrp) (6). in 2010, hospital referral regions (hrrs) in the chicago metropolitan area had higher readmission rates for medical and surgical discharges when compared with the national average (7), and were among the top five hrrs in illinois facing higher penalties (8). although penalizing high readmission rates has been debated since the introduction of the policy (9), there has been consensus on the need for coordinated and efficient care for patients beyond the hospital walls to prevent unnecessary readmissions. augmenting transitions of care during the discharge process and proper coordination between providers across care settings are key drivers needed to reduce preventable readmissions (10-12). preventing readmissions must be followed up with post-discharge and community-based care interventions that can improve, as well as sustain, the health of the population to decrease hospital returns. while several interventions have been developed that aim to reduce unnecessary readmissions by improving the transition of care process during and post-discharge (13-17), there is a lack of evidence on what interventions are most effective with readmission reductions on a broad scale (18). one approach to curtailing readmissions is to identify high risk patients needing effective transition of care interventions using prediction models (19). ideally, the design of prediction models should offer clinically meaningful discrimination ability (measured using the c-statistic); use reliable data that can be easily obtained; utilize variables that are clinically related; be validated in the populations in which use is intended; and be deployable in large populations (20). for a clinical prediction model, a c-statistic of less than 0.6 has no clinical value, 0.6 to 0.7 has limited value, 0.7 to 0.8 has modest value, and greater than 0.8 has discrimination adequate for genuine clinical utility (21). however, prediction models should not rely exclusively on the c-statistic to evaluate utility of risk factors (22). they should also consider bootstrapping methods (23) and incorporate additional performance measures to assess prediction models (24). research also suggests that prediction models should maintain a balance between including too many variables and model parsimony (25, 26). a systematic review of 26 hospital readmission risk prediction models found that most tools performed poorly with limited clinical value (average c-statistic of 0.66), about half relied on retrospective administrative data, a few used external validation methods, and efforts were needed to improve their performance as usage becomes more widespread (27). in addition, a few parsimonious prediction models were developed after this review. one was created outside the u.s. and yielded a c-statistic of 0.70 (28). the other did not perform external validation for geographic scalability and had a c-statistic of 0.71 (29). one of the major limitations of most prediction models is that they are mostly developed using administrative claims data. given the myriad of factors that can contribute to readmission risk, models should also consider including variables obtained in the electronic health record (ehr). a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi fostering collaborative relationships and care coordination with providers across care settings is needed to reduce preventable readmissions (18). care collaboration and coordination is central to the health information technology for economic and clinical health (hitech) act in promoting the adoption and meaningful use of health information (30). therefore, health care providers should also consider collaborating with information technology organizations to develop holistic solutions that improve health care delivery and the health of communities. advocate health care, located in the chicago metropolitan area, and cerner partnered to create optimal predictive models that leveraged advocate health care’s population risk and clinical integration expertise with cerner's health care technology and data management proficiency. the advocate cerner collaboration (acc) was charged with developing a robust readmission prevention solution by improving the predictive power of advocate health care’s current manual readmission risk stratification tool (c-statistic of 0.69), and building an automated algorithm embedded in the ehr that stratifies patients at high risk of readmission needing care transition interventions. the acc developed their prediction models taking into consideration recommendations documented in the literature to create and assess their models’ performance, and performed an external validation for generalizability using a heterogeneous population. while previous work relied solely on claims data, the acc prediction models incorporated patient data from the ehr. in addition, the acc team used a mixed-method approach to evaluate risk factors to include in the prediction models. objectives the objectives of this research project were to: 1) develop all-cause hospital readmission risk prediction models for utility at admission and prior to discharge to identify adult patients likely to return within 30-days; 2) assess the prediction models’ performance using key metrics; and 3) externally validate the prediction models’ generalizability across multiple hospital systems. methods a retrospective cohort study was conducted among adult inpatients discharged between march 1, 2011 and july 31, 2012 from 8 advocate health care hospitals located in the chicago metropolitan area (figure 1). a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 1. geographic location of 8 advocate health care hospitals an additional year of data prior to march 1, 2011, was extracted to analyze historical patient information and prior hospital utilization. inpatient visits thru august 31, 2012, were also extracted to account for any readmissions occurring within 30 days of discharge after july 31, 2012. encounters were excluded from the cohort if they were observation, inpatient admissions for psychiatry, skilled nursing, hospice, rehabilitation, maternal and newborn visits, or if the patient expired during the index admission. clinical data was extracted from cerner’s millennium® ehr software system and advocate health care’s enterprise data warehouse (edw). data from both sources was then loaded into cerner’s powerinsight® (piedw) for analysis. the primary dependent variable for the prediction models was hospital readmissions within 30days from the initial discharge. independent variables were segmented into 8 primary categories: demographics and social characteristics, hospital utilization, history & physical examination (h&p), medications, laboratory tests, conditions and procedures (using international classification of diseases, ninth revision, clinical modification codes icd-9 cm), and an exploratory group (figure 2). a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 2. acc readmission risk prediction conceptual model risk factors considered for analysis were based on literature reviews and a mixed-method approach using qualitative data collected from clinical input. qualitative data were collected from site visits at each advocate health care hospital through in-depth interviews and focus groups with clinicians and care mangers, respectively. clinicians and care mangers were asked to identify potential risk factors that caused a patient to return to hospital. field notes were taken during the site visits. information gleaned was used to identify emerging themes that helped inform the quantitative analyses. all quantitative statistical analyses were conducted using sas® version 9.2 (sas institute). descriptive and inferential statistics were performed on the primary variable categories to identify main features of the data and any causal relationships, respectively. the overall readmission rate was computed using the entire cohort. for modeling, one consecutive encounter pair (index admission and readmission encounter) was randomly sampled from each patient to control for bias due to multiple admissions. index encounters were restricted to a month prior to the study period’s end date to capture any readmissions that occurred within 30 days (figure 3). a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 3. multiple readmission sampling methodology to develop and internally validate the prediction models, the cohort was then split into a derivation dataset (75%) and a validation dataset (25%). model fitting was calculated using bootstrapping method by randomly sampling two-thirds of the data in the derivation dataset. the procedure was repeated 500 times and the averaged coefficients were applied to the validation dataset. stepwise logistic regression was performed and predictors that were statistically significant using a p-value ≤ 0.05 were included in the model. two predictive models were developed: one at admission and one prior to discharge using readily available data for the patient. the admission prediction included baseline data available for a patient once admitted to the hospital. the discharge prediction model was more comprehensive, including additional data that became available prior to discharge. the performance of each prediction model was assessed by 3 measures. first, discrimination ability was quantified by sensitivity, specificity, and the area under the receiver operating characteristic (roc) curve, or c-statistic that measures how well the model can separate those who do and do not have the outcome. second, calibration was performed using the hosmerlemeshow (h&l) goodness-of-fit test, which measures how well the model fits the data or how well predicted probabilities agree with actual observed risk, where a p-value > 0.05 indicates a good fit. third, overall performance was quantified using brier’s score, which measures how close predictions are to the actual outcome. external validation of the admission and discharge prediction models were also performed using cerner’s healthfacts® data. healthfacts® is a de-identified patient database that includes over 480 providers across the u.s. with a majority from the northeast (44%), having more than 500 beds (27%), and are teaching facilities (63%). healthfacts® encompasses encounter level demographic information, conditions, procedures, laboratory tests, and medication data. a sample was selected from healthfacts® data consistent with the derivation dataset. the fit of both prediction models was assessed by applying the derivation coefficients, then recalibrating the coefficients with the same set of predictors and the coefficients by using the healthfacts® sample. the performance between models was then compared. a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi results a total of 126,479 patients comprising 178,293 encounters met the cohort eligibility criteria, of which 18,652 (10.46%) encounters resulted in readmission to the same advocate health care hospital within 30 days. after sampling, 9,151 (7.25%) encounter pairs were defined as 30-day readmissions. demographic characteristics of the sample cohort are characterized in table 1. table 1. demographic characteristics of the sample cohort demographic characteristics 30 day readmission no readmission n=9,151 (7.25%) n=117,328 (92.75%) age µ = 66.01 µ = 57.65 gender female 5,045 (55.13) 70,917 (60.44) male 4,106 (44.87) 46,411 (39.56) race caucasian 5,737 (62.69) 71,796 (61.19) african american 2,357 (25.76) 26,446 (22.54) hispanic 648 (7.08) 10,867 (9.26) other 409 (4.47) 8,219 (7.01) language english 6,851 (94.26) 141,624 (93.29) no english 417 (5.74) 10,187 (6.71) marital status married 3,771 (41.21) 58,159 (49.57) not married 5,380 (58.79) 59,169 (50.43) employment status employed 991 (10.83) 23,073 (19.67) not employed 4,930 (53.87) 46,973 (40.04) unknown 3,230 (35.30) 47,282 (40.30) insurance type commercial 2,828 (30.90) 56,286 (47.97) medicare 5,118 (55.93) 44,187 (37.66) medicaid 778 (8.50) 8,352 (7.12) self-pay 378 (4.13) 6,751 (5.75) other 49 (0.54) 1,752 (1.49) the acc admission model included 49 independent predictors: demographic, utilization, medications, labs, h&p, and exploratory variables. the acc discharge model included 58 independent predictors comprising all the aforementioned variables plus conditions, procedures, length of stay (los), and discharge disposition. the variables included in the acc admission and discharge prediction models are presented in table 2. a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi table 2. acc admission and discharge prediction models’ variables variables admission model (n=49) discharge model (n=58) demographics utilization lab tests exploratory h&p medications conditions procedures length of stay discharge disposition assessment of the acc admission model’s performance yielded c-statistics of 0.76 and 0.75, h&l goodness-of-fit tests of 36.0 (p<0.001) and 23.5 (p=0.0027), and brier scores of 0.062 (7.6% improvement from random prediction) and 0.063 (6.6% improvement from random prediction) from the derivation and internal validation datasets, respectively. assessment of the acc discharge model’s performance yielded c-statistics of 0.78 and 0.77, h&l goodness-of-fit tests of 31.1 (p<0.001) and 19.9 (p=0.01), and brier scores of 0.060 and 0.061 (9.1% improvement from random prediction) from the derivation and internal validation datasets, respectively. the average c-statistic for the acc admission model was 0.76 and for the discharge model it was 0.78 after the 500 simulations in derivation dataset, resulting in a small range of deviation between individual runs. external validation of the acc admission and discharge model resulted in c-statistics of 0.76 and 0.78, h&l goodness-of-fit tests of 6.1 (p=0.641) and 14.3 (p=0.074), and brier scores of 0.061 (8.9% improvement from random prediction) and 0.060 (9.1% improvement from random prediction) after recalibrating and re-estimating the coefficient using healthfacts® data, respectively. the acc admission and discharge models’ performance measures are represented in table 3. a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi table 3. acc admission and discharge prediction model’s performance measures dataset performance measures admission model discharge model derivation (n=94,859) discrimination c-statistic 0.76 0.78 calibration hosmer-lemeshow goodness-offit test (p-value) 36.0 (p<0.001) 31.1 (p<0.001) overall performance brier score (% improvement) 0.062 (7.6%) 0.060 (9.1%) bootstrapping 500 simulations average (min. to max.) 0.76 (0.75 to 0.76) 0.78 (0.77 to 0.78) internal validation (n=31,619) discrimination c-statistic 0.75 0.77 calibration hosmer-lemeshow goodness-offit test (p-value) 23.5 (p=0.003) 19.9 (p=0.01) overall performance brier score (% improvement) 0.063 (6.6%) 0.061 (9.1%) external validation (without recalibration) (n=6,357) discrimination c-statistic 0.69 0.71 calibration hosmer-lemeshow goodness-offit test (p-value) 216.9 (p<0.001) 156.3 (p<0.001) overall performance brier score (% improvement) 0.065 (2.5%) 0.064 (4.0%) external validation (with recalibration) (n=6,357) discrimination c-statistic 0.76 0.78 calibration hosmer-lemeshow goodness-offit test (p-value) 6.1 (p=0.641) 14.3 (p=0.074) overall performance brier score (% improvement) 0.061 (8.9%) 0.060 (9.1%) the probability thresholds for identifying high risk patients (11%), was determined by balancing the tradeoff between sensitivity (70%) and specificity (71%) by maximizing the area under roc curves for the prediction models (figure 4). a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi figure 4. roc curves for acc admission & discharge model discussion we observed several key findings during the development and validation of our acc admission and discharge models. both our all-cause models performed reasonably better than most predictive models reviewed in the literature used to identify patients at risk of readmission (2729). both our models yielded a c-statistic between 0.7 and 0.8 during derivation, internal validation, and external validation after recalibration—a modest value for a clinical predictive rule. when comparing c-statistics between the admission (c-statistic of 0.76) and discharge models (c-statistic 0.78), the discharge model’s discrimination ability improved because conditions and procedures, los, and discharge disposition variables were included; which helped further explain a patient’s readmission risk since medical conditions and surgical procedures accounts for immediate health needs, los represents severity of illness, and discharge disposition to a post-acute setting that doesn’t meet their discharge needs could result in a return to the hospital. we also observed the same c-statistic for our acc discharge model on the development and external validation sample, suggesting that it performs well both in the intended population and when using a heterogeneous dataset. our acc discharge model also had a somewhat higher c-statistic during derivation when compared to the c-statistic observed during internal validation (c-statistic of 0.77), which is typically higher when assessing predictive accuracy using the derivation dataset to develop the model (21). our acc admission and discharge models also demonstrated reasonable model fit during external validation after recalibrating the coefficient estimates. a non-significant h&l p-value indicates the model adequately fits the data. however, caution must be used when interpreting h&l statistics because they are influenced by sample size (31). our models did not demonstrate adequate model fit during derivation and internal validation due to a large sample. yet during a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi external validation with a smaller sample, the h&l statistics for both the acc admission and discharge model improved to a non-significant level. since the h&l statistic is influenced by sample size, the brier score should also be taken into account to assess prediction models because it captures calibration and discrimination features. the closer the brier score is to zero, the better the predictive performance (24). both our prediction models had low brier scores, with the acc discharge model’s 0.06 representing consistent percent (9.1%) improvement over random prediction during derivation, internal validation, and external validation after recalibration. there was concern that too many independent variables would increase the possibility of building an over-specified model that only performs well on the derivation dataset. thus, validating a comprehensive model using an external dataset to replicate the derivation results would be challenging. our findings indicate that our model’s performance slightly diminished during the acc admission model’s external validation when compared with the more comprehensive acc discharge model. when we externally validated our acc admission model, the c-statistic was 0.74 on the development dataset, but reduced to 0.66 when using the initial derivation coefficients on the external dataset, and then increased to 0.70 after recalibrating the coefficients. the c-statistic for our acc discharge model decreased from 0.78 on the development dataset, to 0.71 using the unchanged derivation coefficients, and then increased back to 0.78 after recalibration using the external validation sample dataset. it is expected to see performance decrease from derivation to validation, but our models had no more than 10% shrinkage from derivation to the validation results (32). we further tested our acc admission model using only baseline data available for a patient (e.g., demographic and utilization variables). the c-statistic for a more parsimonious admission model was 0.74 on the development dataset, decreased to 0.66 when using the derivation coefficients on the external dataset, but then increased to 0.70 after recalibrating the coefficients. our findings suggest that including additional variables in the model is more likely to generalize better in comparison with a parsimonious model during external validation post-recalibration. overall, our admission and discharge models’ performance indicates modest discrimination ability. while other studies relied on retrospective administrative data, our models incorporated data elements from the ehr. we utilized a mixed-method approach to evaluate clinically-related variables. our models were internally validated in the intended population and externally validated for utility in heterogeneous populations. our admission model offers a practical solution with data available during hospitalization. our discharge model has a higher level of predictability according to the c-statistic and improved performance according to the brier score once more data is accessible during discharge. creating a highly accurate predictive model is multifaceted and contingent on copious factors, including, but not limited to, the quality and accessibility of data, the ability to replicate the findings beyond the derivation dataset, and the balance between a parsimonious and comprehensive prediction model. to facilitate external validation, we discovered that a compromise between a parsimonious and comprehensive model was needed when developing logistic regression prediction models. we also found that utilizing a mixed-method approach was valuable and additional efforts are needed when selecting risk factors that are of high-quality data, easily accessible, and generalizable across multiple populations. we also believe that a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi bridging statistical acumen and clinical knowledge is needed to further develop decision support tools of genuine clinical utility, by soliciting support from clinicians when the statistics does not align with clinical intuition. limitations our findings should be considered under the purview of several limitations. there might be additional research conducted on readmission risk tools developed after the systematic review performed by kansagara. additional readmission risk prediction models were developed (33, 34), but they did not publish their performance statistics to help us compare our prediction models. our readmission rate was limited to visits occurring at the same hospital. readmission rates based on same-hospital visits can be unreliable and dilute the true hospital readmission rate (35). one promising approach is using a master patient index (mpi) to track patients across hospitals. data is being linked across hospitals and to outside facilities through mpi and claims data. using our own method to create a mpi match, we performed some preliminary analysis and were able to identify 5% more readmissions across the other advocate health care hospitals, increasing the readmission rate by approximately 1%. we also assessed the utility of claims data to match the other hospitals with millennium® encounters to gauge a more representative readmission rate. the claims data allowed us to track approximately 8% more readmissions, increasing the readmission rate by approximately 1%. overall, using both approaches we were able to identify a more representative readmission rate that increased from 10.46% to 12.5%. we are currently working to see how this impacts our models’ performance. data captured through ehrs is growing, but are incomplete with respect to data relevant to hospital readmission prediction and the lack of standard data representations limits generalizability of predictive models (36). as a result, we could not include certain data elements into our models due to data quality issues, a large percentage of missing data, and since some of the information is difficult to glean. therefore, we could not include social determinants identified by clinicians and care managers during qualitative interviews such as social isolation (i.e., living alone) and living situation (e.g., homelessness) known to be salient factors and tied to hospital readmissions (37, 38). initially, we only mined a single source for this information in the ehr. however, new data sources have been identified in the ehr and the utility of these risk factors are currently being assessed in our prediction models. additional factors are also being considered in our models such, as functional status (37, 39), medication adherence and availability of transportation for follow-up visits post-discharge (40). our prediction models do not distinguish between potentially preventable readmissions (ppr) (41, 42). we did perform some preliminary analysis and found that the overall ppr readmission rate for advocate health care in 2012 was about 6% of all admissions. we estimated around 60% of all readmissions were deemed avoidable. this is higher than the median proportion of avoidable readmissions (27.1%), but falls within the range of 5% to 79% (43). we plan to further assess ppr methodology and test our models’ ability to recognize potentially avoidable readmissions to help intervene where clinical impact is most effective. a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi our initial analysis plan proposed to include observation patients (n=51,517) in the entire inpatient cohort. we performed some preliminary analysis and found the overall readmission rate increased to 10.72%, but the c-statistics for our admission and discharge models reduced to 0.75 and 0.77, respectively. our models’ discrimination ability probably diminished due to improved logic needed in making a distinction in situations where observation status changes to inpatient and vice-versa. further assessment of observation patients is needed to better understand their importance in an accountable care environment. steps are underway to mitigate limitations and continue to improve the clinical utility of our readmission risk prediction models. data is being linked across hospitals and to outside facilities through mpi and claims data. additional data sources in the ehr that encompass social determinants and other risk factors were identified are being assessed for use in our models. also, we are researching potentially preventable readmissions so that the models can focus on cases where clinical impact is most needed. conclusions the acc admission and discharge models exemplify design qualities of ideal prediction models. both our models demonstrated modest predictive power for identifying high-risk patients early during hospitalization and at hospital discharge, respectively. performance assessment of both our models during external validation post-recalibration indicates reasonable model fit and can be deployed in other population settings. our admission model offers a practical and feasible solution with limited data available on admission. our discharge model offers improved performance and predictability once more data is presented during discharge. the acc partnership offers an opportunity to leverage proficiency from both organizations to improve and continue in the development of valuable clinical prediction models, building a framework for future prediction model development that achieves scalable outcomes. corresponding author shahid a. choudhry, phd 1 clinical intelligence researcher, advocate cerner collaboration (acc) ali.choudhry@cerner.com acknowledgements mitali barman, ms 2 , technical architect, acc sam bozzette, md, phd 1 , physician executive, cerner research darcy davis, phd 2 , data scientist, acc cole erdmann, mba 1 , project manager, acc tina esposito, mba 2 vp, center for health information services (chis) zachary fainman, md 2 , director medical care management mary gagen, mba 2 , manager, business analytics, chis harlen d. hays, mph 1 , manager, quantitative research and biostatistics stephen himes, jd, phd, copy editor qingjiang hou, ms 1 , scientist, life science research a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi andrew a. kramer, phd 1 , senior research manager, critical care abu jing li, phd 1 , data analyst, acc douglas s. mcnair md, phd 1 , engineering fellow & president, cerner math bryan nyary, mba, medical editor samir rishi, bsrt, mha, lean 2 , clinical process designer, acc lou ann schraffenberger, manager, clinical data, chis rishi sikka, md 2 , vp, clinical transformation rajbir singh, ms 1 , engineer, acc bharat sutariya, md 1 , vp & cmo, population health xinyong tian, phd 2 , data analyst, acc luke utting, bs 1 , senior engineer, acc fran wilk, rn, bsn, ma 2 , clinical process designer, acc center for health information services team 2 advocate health care hospital site visit participants 2 references [1] jencks sf, williams mv, coleman ea. rehospitalizations among patients in the medicare fee-for-service program. new engl j med. 2009 apr 2;360(14):1418-28. [2] berwick dm, hackbarth ad. eliminating waste in us health care. jama. 2012 april 11;307(14):1513-1516. [3] boutwell a, jencks s, nielsen g, et al. state action on avoidable rehospitalizations (staar) initiative: applying early evidence and experience in front-line process improvements to develop a state based strategy. cambridge, ma: institute for healthcare improvement; 2009 may 1[cited 2013 apr 15]. available from: http://www.ihi.org/offerings/initiatives/staar/documents/staar%20state%20based% 20 strategy.pdf. [4] medicare payment advisory commission (medpac). washington, dc: report to the congress: reforming the delivery system; 2008 june 13 [cited 2013 april 22]. available from: http://www.medpac.gov/documents/jun08_entirereport.pdf. [5] patient protection and affordable care act, pub. l. no. 111-148, §2702, 124 stat. 119, 318-319 (march 23, 2010). [6] centers for medicaid and medicare services. readmissions reduction program; 2012 oct 1[cited 2013 apr 15]. available from: http://www.cms.gov/medicare/medicare-fee-forservice-payment/acuteinpatientpps/readmissions-reduction-program.html. [7] goodman dc, fisher es, chang ch. after hospitalization: a dartmouth atlas report on post-acute care for medicare beneficiaries. lebanon, nh: the dartmouth institute for health policy and clinical practice; 2011 sept 28 [cited 2013 apr 15]. available from: http://www.dartmouthatlas.org/downloads/reports/post_discharge_events_092811.pdf. [8] kaiser health news. 2013 medicare readmissions penalties by state; 2012 aug 13 [updated 2012 oct 22; cited 2013 apr 30]. available from: http://www.kaiserhealthnews.org/stories/2012/august/13/2013-readmissions-by-state.aspx. [9] joynt ke, jha ak. a path forward on medicare readmissions. n engl j med. 2013 mar 28; 368:1175-1177. http://www.ihi.org/offerings/initiatives/staar/documents/staar%20state%20based%20%20strategy.pdf. http://www.ihi.org/offerings/initiatives/staar/documents/staar%20state%20based%20%20strategy.pdf. http://www.medpac.gov/documents/jun08_entirereport.pdf http://www.cms.gov/medicare/medicare-fee-for-service-payment/acuteinpatientpps/readmissions-reduction-program.html http://www.cms.gov/medicare/medicare-fee-for-service-payment/acuteinpatientpps/readmissions-reduction-program.html http://www.dartmouthatlas.org/downloads/reports/post_discharge_events_092811.pdf http://www.kaiserhealthnews.org/stories/2012/august/13/2013-readmissions-by-state.aspx a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [10] medicare payment advisory commission (medpac). report to congress: promoting greater efficiency in medicare; 2007 june 15 [cited 2013 apr 15]. available from: http://www.medpac.gov/documents/jun07_entirereport.pdf. [11] sunil k, lefevre f, phillips co, williams mv, basaviah p, baker dw. deficits in communication and information transfer between hospital-based and primary care physicians. jama. 2007 feb 28; 297(8): 831-841. [12] tilson s, hoffman gj. addressing medicare hospital readmissions. congressional research service; 2012 may 25 [cited 2013 apr 30]. [13] jack bw, chetty vk, anthony d, et al. a reengineered hospital discharge program to decrease rehospitalization. ann intern med. 2009;150:178–187. [14] parry c, min sj, chugh a, chalmers s, coleman ea. further application of the care transitions intervention: results of a randomized controlled trial conducted in a fee-forservice setting. home health care. serv q. 2009;28:84–99. [15] coleman ea, parry c, chalmers s, min sj. the care transitions intervention: results of a randomized controlled trial. arch intern med. 2006;166:1822–1828. [16] naylor md, brooten d, campbell r, et al. comprehensive discharge planning and home follow-up of hospitalized elders: a randomized clinical trial. jama. 1999;281:613–620. [17] project boost team. the society of hospital medicine care transitions implementation guide: project boost: better outcomes by optimizing safe transitions. society of hospital medicine website, care transitions quality improvement resource room. [cited 2013 apr 30]. avaiable from: http://www.hospitalmedicine.org. [18] mittler jn, o'hora jl, harvey jb, press mj, volpp kg, scanlon dp. turning readmission reduction policies into results: some lessons from a multistate initiative to reduce readmissions. popul health manag. 2013 feb 25. [epub ahead of print] [19] brennan, n. centers for medicare & medicaid services: applying smart analytics to the medicare readmission problem. 2012 oct 16 [cited apr 15, 2013] available from: http://strataconf.com/rx2012/public/schedule/detail/27500. [20] krumholz hm, brindis rg, brush je, et al. american heart association; quality of care and outcomes research interdisciplinary writing group; council on epidemiology and prevention; stroke council; american college of cardiology foundation; endorsed by the american college of cardiology foundation. standards for statistical models used for public reporting of health outcomes: an american heart association scientific statement from the quality of care and outcomes research interdisciplinary writing group: cosponsored by the council on epidemiology and prevention and the stroke council. circulation. 2005 dec 19;113(3):456-462. [21] ohman e, granger cb, harrington ra, lee kl. risk stratification and therapeutic decision making in acute coronary syndromes. jama. 2000 aug 16;284(7):876-878. [22] cook nr. use and misuse of the receiver operating characteristics curve in risk prediction. circulation. 2007 aug 7;115(7):928–935. [23] austin pc, tu jv. bootstrap methods for developing predictive models. am stat. 2004 may;58(2):131-137. [24] steyerberg ew, vickers aj, cook nr, gerds t, gonen m, et al. assessing the performance of prediction models: a framework for traditional and novel measures. epidemiology: 2010 jan;21(1):128-138. [25] murtaugh pa. methods of variable selection in regression modeling. communications in statistics, simulation and computation. 1998; 27(3):711-734. http://www.medpac.gov/documents/jun07_entirereport.pdf http://www.hospitalmedicine.org/ http://strataconf.com/rx2012/public/schedule/detail/27500 a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [26] wears, rl, roger jl. statistical models and occam's razor. academic emergency medicine. 1999;6 (2):93-94. [27] kansagara d, englander h, salanitro a, et al. risk prediction models for hospital readmission: a systematic review. jama. 2011;306(15):1688-1698. [28] billings j, blunt i, steventon a, georghiou t, lewis g, bardsley m. development of a predictive model to identify inpatients at risk of re-admission within 30 days of discharge (parr-30). bmj open. 2012 aug 10;2(4). [29] donzé j, aujesky d, williams d, schnipper jl. potentially avoidable 30-day hospital readmissions in medical patients: derivation and validation of a prediction model. jama intern med. 2013 apr 22;173(8):632-638. [30] u.s. department of health & human services. hitech act enforcement interim final rule; 2009 feb 18 [cited 2013 april 30]. available from: http://www.hhs.gov/ocr/privacy/hipaa/administrative/enforcementrule/hitechenforcementifr .html. [31] kramer aa, zimmerman je. assessing the calibration of mortality benchmarks in critical care: the hosmer-lemeshow test revisited. crit care med. 2007 sep;35(9):2052-2056. [32] patetta m, kelly d. predictive modeling using logistic regression. sas institute inc. 2008jul. [33] the advisory board company. about crimson real time readmissions. 2013 [cited 2013 apr 22]. accessed from: http://www.advisory.com/technology/crimson-real-timereadmissions/about-crimson-real-time-readmissions. [34] ibm. new ibm software helps analyze the world's data for healthcare transformation. seton healthcare family adopts complementary watson solution to improve patient care and help reduce costs. 2011 oct 25 [cited 2013 apr 22]. accessed from: http://www-03.ibm.com/press/us/en/pressrelease/35597.wss. [35] nasir k, lin z, bueno h, normand sl, drye ee, keenan ps, et al. is same-hospital readmission rate a good surrogate for all-hospital readmission rate? med care. 2010 may;48(5):477-81. [36] cholleti s, post a, gao j, lin x, bornstein w, cantrell d, saltz j. leveraging derived data elements in data analytic models for understanding and predicting hospital readmissions. amia annu symp proc. 2012 nov 3;2012:103-111. [37] arbaje ai, wolff jl, yu q, powe nr, anderson gf, boult c. postdischarge environmental and socioeconomic factors and the likelihood of early hospital readmission among community-dwelling medicare beneficiaries. gerontologist. 2008 aug;48(4):495504. [38] calvillo-king l, arnold d, eubank kj, lo m, yunyongying p, stieglitz h, halm ea. impact of social factors on risk of readmission or mortality in pneumonia and heart failure: systematic review. j gen intern med. 2013 feb;28(2):269-82 [39] coleman ea, min sj, chomiak a, kramer am. posthospital care transitions: patterns, complications, and risk identification. health serv res. 2004;39(5):1449-1465. [40] alper e, o'malley ta, greenwald j. hospital discharge. up to date. 2013 mar 25 [cited 2013 apr 15]. available from: http://www.uptodate.com/contents/hospital-discharge. [41] goldfield ni, mccullough ec, hughes js, ang am, eastman b, rawlins lk, averill rf. identifying potentially preventable readmissions. health care financ rev. 2008 fall;30(1):75–91. http://www.hhs.gov/ocr/privacy/hipaa/administrative/enforcementrule/hitechenforcementifr.html http://www.hhs.gov/ocr/privacy/hipaa/administrative/enforcementrule/hitechenforcementifr.html http://www.advisory.com/technology/crimson-real-time-readmissions/about-crimson-real-time-readmissions http://www.advisory.com/technology/crimson-real-time-readmissions/about-crimson-real-time-readmissions http://www-03.ibm.com/press/us/en/pressrelease/35597.wss http://www.uptodate.com/contents/hospital-discharge a public-private partnership develops and externally validates a 30-day hospital readmission risk prediction model 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi [42] vest jr, gamm ld, oxford ba, gonzalez mi, slawson km. determinants of preventable readmissions in the united states: a systematic review. implement sci. 2010 nov 17;5:88. [43] van walraven c, bennett c, jennings a, austin pc, forster aj. proportion of hospital readmissions deemed avoidable: a systematic review. cmaj. 2011;183(7):391-402. layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts syndromic surveillance based on emergency visits: a reactive tool for unusual events detection pascal vilain*1, arnaud bourdé2, pierre-jean marianne dit cassou3, yves jacquesantoine4, philippe morbidelli5 and laurent filleul1 1regional office of the french institute for public health surveillance of indian ocean, saint-denis, reunion; 2university hospital, saint-denis, reunion; 3university hospital, saint-pierre, reunion; 4hopital center, saint-benoît, reunion; 5hopital center, saint-paul, reunion objective to show with examples that syndromic surveillance system can be a reactive tool for public health surveillance. introduction the late health events such as the heat wave of 2003 showed the need to make public health surveillance evolve in france. thus, the french institute for public health surveillance has developed syndromic surveillance systems based on several information sources such as emergency departments (1). in reunion island, the chikungunya outbreak of 2005-2006, then the influenza pandemic of 2009 contributed to the implementation and the development of this surveillance system (2-3). in the past years, this tool allowed to follow and measure the impact of seasonal epidemics. nevertheless, its usefulness for the detection of minor unusual events had yet to be demonstrated. methods in reunion island, the syndromic surveillance system is based on the activity of six emergency departments. two types of indicators are constructed from collected data: qualitative indicators for the alert (every visit whose diagnostic relates to a notifiable disease or potential epidemic disease); quantitative indicators for the epidemic/cluster detection (number of visits based on syndromic grouping). daily and weekly analyses are carried out. a decision algorithm allows to validate the signal and to organize an epidemiological investigation if necessary. results each year, about 150 000 visits are registered in the six emergency departments that is 415 consultations per day on average. several unusual health events on small-scale were detected early. in august 2011, the surveillance system allowed to detect the first autochthonous cases of measles, a few days before this notifiable disease was reported to health authorities (figure 1). in january 2012, the data of emergency departments allowed to validate the signal of viral meningitis as well as to detect a cluster in the west of the island and to follow its trend. in june 2012, a family foodborne illness was detected from a spatio-temporal cluster for abdominal pain by the surveillance system and was confirmed by epidemiological investigation (figure 2). conclusions despite the improvement of exchanges with health practitioners and the development of specific surveillance systems, health surveillance remains fragile for the detection of clusters or unusual health events on small scale. the syndromic surveillance system based on emergency visits has proved to be relevant for the identification of signals leading to health alerts and requiring immediate control measures. in the future, it will be necessary to develop these systems (private practitioners, sentinel schools) in order to have several indicators depending on the degree of severity. figure 1. epidemic curve of measles cases figure 2. line-list of patient characteristics in an abdominal pain cluster. keywords syndromic surveillance; unusual event detection; reunion island acknowledgments we are thankful to all the practitioners of emergency departments. references 1. josseran l, nicolau j, caillère n, astagneau p, brücker g. syndromic surveillance based on emergency department activity and crude mortality: two examples. euro surveill. 2006;11(12):225-9. 2. d’ortenzio e, do c, renault p, weber f, filleul l. enhanced influenza surveillance on réunion island (southern hemisphere) in the context of the emergence of influenza a(h1n1)v. euro surveill. 2009;14(26). pii: 19257. 3. filleul l, durquety e, baroux n, chollet p, cadivel a, lernout t. the development of non-specific surveillance in mayotte and reunion island in the contexte of the epidemic influenza a(h1n1) 2009 [article in french]. bull epidemiolhebd. 2010:283. *pascal vilain e-mail: pascal.vilain@ars.sante.fr online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e150, 2013 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluating usefulness of maine’s syndromic surveillance system for hospitals, 2012 stefanie devita* and amy robbins infectious disease epidemiology, maine cdc, augusta, me, usa objective to assess the usefulness and acceptability of maine’s syndromic surveillance system among hospitals who currently participate. introduction maine has been conducting syndromic surveillance since 2007 using the early aberration reporting system (ears). an evaluation of the syndromic surveillance system was conducted to determine if system objectives are being met, assess the system’s usefulness, and identify areas for improvement. according to cdc’s guidelines for evaluating public health surveillance systems, a surveillance system is useful if it contributes to the timely prevention and control of adverse health events. acceptability includes the willingness of participants to report surveillance data; participation or reporting rate; and completeness of data. methods results a weekly basis, including a statewide data summary, as useful. respondents also recommended that data be shared back with participants using 30-day line graphs for each syndrome (4 respondents). the three syndromes respondents found most useful were influenzalike illness (7 respondents), gastrointestinal (5 respondents), and respiratory (5 respondents). the three syndromes respondents found least useful were the broad heat syndrome (4 respondents), the narrow heat syndrome (4 respondents), and the other syndrome that captures all visits not classified into any syndrome (4 respondents). chief complaint data, which is used to classify emergency department visits into syndromes, is most often recorded by a drop-menu (4 respondents). conclusions with a low survey completion rate, it is difficult to generalize responses to all hospitals who participate in syndromic surveillance. hospitals that did not respond to or complete the survey will be followed up with to determine their reasons for not doing so, as this may be useful information. in general, those who responded have more factors that influence them to contribute to syndromic surveillance than factors that hinder them. most hospitals find the current method of sharing data back with the hospitals useful. also, it is advantageous to know which syndromes the hospitals find most useful, as they are the entities that collect and report the data. opinions differ among system users, which is why it is important to evaluate a system throughout all points of interaction. keywords syndromic surveillance; evaluation; acceptability acknowledgments the authors would like to acknowledge those hospital partners who completed the survey. references updated guidelines for evaluating public health surveillance systems. (2001) morbidity and mortality weekly report, 50(rr13);1-35. retrieved from http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5013a1.htm *stefanie devita e-mail: stefanie.devita@maine.gov a survey was created in 2012 to measure usefulness and acceptability among hospital partners who submit emergency department data to maine cdc for syndromic surveillance. currently, 24 of maine's 37 emergency departments collect syndromic surveillance data and 20 of those receive a weekly syndromic surveillance report from maine cdc. the survey was included with the report on august 14, 2012, and hospitals were given two weeks for completion. the survey included questions about how useful hospitals find syndromic surveillance and how data is shared back with the hospitals; which syndromes are most and least useful; and chief complaint data collection at individual hospitals. the survey was completed by 13 out of 22 emergency departments (59% participation rate), and six out of 13 respondents (46%) completed the entire survey. the factors reported as having an influence on a hospital's decision to submit data for syndromic surveillance were: public health importance of events (6 respondents) and assurance of privacy/confidentiality (5 respondents). the majority of respondents (5 respondents) reported that there are no factors that limit their ability to send emergency department data. among hospitals that did report factors that limit their ability to send data, lack of information technology support in the hospital (2 respondents) and manually entering data/lack of electronic health records (1 respondent) were the most frequently reported. six out of seven hospitals who answered (86%) reported the current method of sharing syndromic surveillance data on online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e174, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts evaluation of cholera and other diarrheal disease surveillance system, niger state, nigeria-2012 adebobola t. bashorun*1, anthony ahumibe1, saliman olugbon1, patrick nguku1 and kabir sabitu2 1nigeria field epidemiology and laboratory training program, fct, nigeria; 2ahmadu bello university, zaria, nigeria objective to determine how the cholera and other diarrheal disease surveillance system in niger state is meeting its surveillance objectives, to evaluate its performance and attributes and to describe its operation to make recommendations for improvement. introduction cholera causes frequent outbreaks in nigeria, resulting in mortality. in 2010 and 2011, 41,936 cases (case fatality rate [cfr]-4.1%) and 23,366 cases (cfr-3.2%) were reported (1). reported cases in nigeria by week 26, 2012 was 309 (cfr-1.29%) involving 20 local government areas in 6 states. in nigeria, there are currently eleven (11) states including niger state at high risk for cholera/bloodless diarrhea outbreaks. in 2011, niger state had 2472 cholera cases (cfr-2%) and 45,111 other diarrhea diseases cases, recorded in more than half of state purpose of surveillance system is to ensure early detection of cholera and other diarrheal cases and to monitor trends towards evidencebased decision for management, prevention and control. methods we conducted evaluation in july, 2012. we used cdc guideline on surveillance system evaluation (2001) as guide to assess operation, performance and attributes (2). we conducted key informant/in-depth interviews with stakeholders. we examined cholera action plans for preparedness and response, conducted laboratory assessment, extracted and analyzed cholera surveillance (2005-2012) for frequencies/proportions using microsoft excel. thematic analysis was done for qualitative data. we shared findings with stakeholders at all levels. results surveillance system was setup for early detection and monitoring towards evidence-based decision. state government funds system. case definition used is highly sensitive and is any patient aged 5 years or more who develops acute watery diarrhea, with/without vomiting. though simple case definition, laboratory confirmation makes surveillance complex. a passive system, active during outbreaks; has formal and informal sources of information and part of integrated disease surveillance and response (idsr) system and flow(fig.1). it takes 24-48 hours between outbreaks onset, confirmation and response. line list showed undefined/poorly labeled outcomes. of 2472 cases in 2011 1320 (49%) were found in line list. 2011 monthly data completeness was 75%. so far in 2012, 5(0.02%) of all diarrhea cases were cholera. system captures only age as sociodemographics. of 11 suspected cholera cases tested during 2011 epidemic, 7 confirmed as cholera (ppv-63%). of 3 rumours of cholera outbreaks (january 2011-july 2012), one (ppv-33%) was true. acceptability of system is high among all stakeholders interviewed. timeliness of monthly reporting was 68.7% (table 1). laboratory can isolate vibro cholerae isolation but has no cary blair transport medium and cholera rapid test kits. conclusions evaluation revealed that surveillance system is meeting its objectives by early detection and response to cholera outbreaks. system is simple, stable, flexible, sensitive with poor data quality, low ppv, fair laboratory capacity and moderate timeliness. we recommended electronic and internet-based reporting for timeliness and data quality improvement; and provision of laboratory consumables. table 1. summary of performance attributes of cholera surveillance system, niger state, 2012. keywords surveillance; evaluation; cholera; nigeria acknowledgments niger state ministry of health references 1. federal ministry of health, nigeria weekly epidemiology reports, ncdc/federal ministry of health – nigeria volume 1 no 1-52. 2011 2. centers for disease control and prevention. updated guidelines for evaluating public health surveillance systems: recommendations from the guidelines working group. mmwr 2001;50 (no. rr-13) *adebobola t. bashorun e-mail: bashogee@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e146, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts fsws typology and condoms use among hiv high risk groups in sindh, pakistan: a developing country perspective suleman m. otho*1, shazia perveen2 and qamar abbas1 1aga khan university hospital, karachi, pakistan; 2global funds for aids, tb and malaria, round 9, sindh aids control program, karachi, pakistan objective we aimed to determine the association of fsws typology with condom use among hiv high risk groups in sindh, pakistan introduction hiv is growing rapidly worldwide resulting in estimated 34 million population [1]. recently, its epidemic has spread in africa, latin america, and the caribbean, and most parts of asia [2]. according to antenatal sero surveillance study conducted in 2011 by agriteam canada, it’s prevalence in pakistan is <0.1 [3].focusing narrowly, its prevalence in sindh, (one of the provinces of pakistan) is similar in general population, but it is in the phase of concentrated epidemic (having more than 5% of prevalence in high risk groups)in vulnerable groups like idus and male sex workers and transgender [4]. sexual intercourse has been identified as major route especially in hiv high risk groups including male sex workers, female sex workers (fsws), transgender (hijras) and iv drug users. among them, fsws are at high risk because of unprotected sex and illicit drug use. their prevalence is found to be 30.7% in low and middle income countries [5]. south asia contributed with 12.63 lakh fsw in india only [6]. on the basis of their station of work, they are categorized into facility based (kothikhana, brothel or home) and mobile (street, mobile or beggars). they use different preventive measures including condom for their protection from hiv [7]. it varies with availability and access [8] . fsws typology have different cliental and mode of action, therefore, it important to explore the preventive methods. methods data was extracted from second generation surveillance, integrated behavioral and biological survey, round iv for hiv infection conducted by agriteam canada in partnership with national aids control program, pakistan in 2011. it was a cross sectional survey for high risk groups including fsws from pakistan. it was ethically approved by review board of the public health agency of canada and hope international’s ethical review board, pakistan. from sindh province, fsws based in karachi, sukkur and larkana were recruited. considering typology, they were categorized as mobile or facility based. after informed consent, socio-demographic and risk behavior were inquired. hiv was tested by elisa/eia and confirmed by western blot. data was analyzed on spss 19. continuous variables were expressed as mean±sd while categorical as frequency(%). logistic regression assessed the association of fsws typology with condoms use among hiv high risk groups. results out of 4567 high risk population, 1127 were identified as fsws. mean age was 26.9 years. most of them were facility based (72.8%) and 81.3% used condoms. typology, age, education, duration of involvement, number of client per day, number of paid oral sex per month, knowledge about sti and knowledge about drop in center were significantly associated with condom use among hiv high risk groups. conclusions majority of facility based fsws use condoms to prevent hiv infection. awareness and access to home based fsws should be increased. it may help in targeting and designing preventive strategies for them at government and mass level. keywords fsw; typology; condoms; hiv high risk groups; pakistan references world health organization. global summary of hiv/aids epidemic december 2010. accessed on june 19, 2012. url: http://www.who.int/ hiv/data/en/. 2. unaids. 2010. unaids report on the global hiv epidemic: 2010. accessed on june 19, 2012. url: http://www.unaids.org/globalreport/global_report.htm. 3. usaid/ pakistan: hiv/ aids health profile. accessed on june 19, 2012. url: http://www.usaid.gov/our_work/global_health/aids/ countries/asia/pakistan_profile.pdf. 4. enhanced hiv/aids control program sindh. data. accessed on june 19 2012. url: http://www.sacp.org.pk/data.php. 5. baral s, beyrer c, muessig k, poteat t, wirtz al, decker mr, et al. burden of hiv among female sex workers in low-income and middleincome countries: a systematic review and meta-analysis. lancet infect dis. 2012:doi:10.1016/s473-3099(12)70066-x. 6. annual report 2010-11. national aids control organization: department of aids control. accessed on june 19, 2012. url: http://www.nacoonline.org/upload/reports/naco%20annual%20report%202010-11.pdf. 7. joseph tfl, amy syt, tsui hs. the relationship between condom use, sexually transmitted diseases, and location of commercial sex transaction among male hong kong clients. aids: epidemiology & social. 2003;17(1):105-12. 8. morris cn, morris sr, ferguson ag. sexual behavior of female sex workers and access to condoms in kenya and uganda on the transafrica highway. aids behav. 2009 oct;13(5):860-5. *suleman m. otho e-mail: drotho@hotmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e141, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts mental illness and co-morbid conditions: biosense 2008 2011 achintya n. dey*, anna grigoryan, soyoun park, stephen benoit and taha kass-hout dndhi, cdc, atlanta, ga, usa objective the purpose of this paper was to analyze the associated burden of mental illness and medical comorbidity using biosense data 20082011. introduction understanding the relationship between mental illness and medical comorbidity is an important aspect of public health surveillance. in 2004, an estimated one fourth of the us adults reported having a mental illness in the previous year (1). studies showed that mental illness exacerbates multiple chronic diseases like cardiovascular diseases, diabetes and asthma (2). biosense is a national electronic public health surveillance system developed by the centers for disease control and prevention (cdc) that receives, analyzes and visualizes electronic health data from civilian hospital emergency departments (eds), outpatient and inpatient facilities, veteran administration (va) and department of defense (dod) healthcare facilities. although the system is designed for early detection and rapid assessment of all-hazards health events, biosense can also be used to examine patterns of healthcare utilization. methods we used 4 years (2008 – 2011) of biosense civilian hospitals’ eds visit data to perform the analysis. we searched final diagnoses for icd-9 cm codes related to mental illness (290 – 312), schizophrenia (295), major depressive disorder (296.2 – 296.3), mood disorder (296, 300.4 and 311) and anxiety, stress & adjustment disorders (300.0, 300.2, 300.3, 308, and 309). we used biosense syndromes/sub-syndromes based on chief complaints and final diagnoses for comorbidity. for the purpose of this study, comorbidity was defined broadly as the co-occurrence of mental and physical illness in the same person regardless of the chronological order. the proportion was calculated as the number of mental health visits associated with comorbidity divided by the total number of mental illness relevant visits. we ranked the top 10 proportions of comorbidity for adult mental illness by year. results from 2008-2011, there were 4.6 million visits where mental illness was reported in the eds visits. average age of those reported mental illness was 44 years, 55% were women and 45% were men. more women were reported with anxiety (67%), mood (66%), and major depressive disorders (59%) than men; while men were reported more with schizophrenia (56%) than women (44%). the most common comorbid condition was hypertension, followed by chest pain, abdominal pain, diabetes, nausea & vomiting and dyspnea (table 1). ranks of injury, falls, headache and asthma were slightly variant by year. conclusions this study supports prior findings that adult mental illness is associated with substantial medical burden. we identified 10 most common comorbid condition associated with mental illness. the major limitation of this work was that electronic data does not allow determination of the causal pathway between mental illness and some medical comorbidity. in addition, data represents only those who have access to healthcare or those with health seeking behaviors. familiarity with comorbid conditions affecting persons with adult mental illness may assist programs aimed at providing medical care for the mentally ill. table1. rankings of comorbidity conditions reported in adults wiht episodes of mental illness in eds keywords ed visits; adult mental illness; medical comorbidity references [1] kessler rc, heeringa s, lacoma md et al individual and societal effects of mental disorders on earnings in the united states: results from the national comorbidity survey replication. am.j.psychiatry 2008; 165:703-11 [2] chapman dp, perry gs, strine tw. the vital link between chronic disease and depressive disorders. prev.chronic dis 2005;2;a14 *achintya n. dey e-mail: adey@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e59, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts loinc and snomed ct code use in electronic laboratory reporting—us, 2011 sanjaya dhakal*1, sherry l. burrer1, carla a. winston2, mathew miller3 and samuel l. groseclose4 1cdc/osels/phsipo, atlanta, ga, usa; 2department of veterans affairs, washington, dc, usa; 3mcking consulting, atlanta, ga, usa; 4cdc/ophpr/sphp, atlanta, ga, usa objective to examine the use of loinc and snomed ct codes for coding laboratory orders and results in laboratory reports sent from 63 non-federal hospitals to the biosense program in calendar year 2011. introduction monitoring laboratory test reports could aid disease surveillance by adding diagnostic specificity to early warning signals and thus improving the efficiency of public health investigation of detected signals. laboratory data could also be employed to direct and evaluate interventions and countermeasures, while monitoring outbreak trends and progress; this would ultimately result in better outbreak response and management, and enhanced situation awareness. since electronic laboratory reporting (elr) has the potential to be more accurate, timely, and cost-effective than reporting by other means of communication (e.g., mail, fax, etc.), elr adoption has been systematically promoted as a public health priority. however, the continuing use of non-standard, local codes or text to represent laboratory test type and results complicates the use of elr data in public health practice. use of structured, unique, and widely available coding system(s) to support the concepts represented by locally assigned laboratory test order and result information improves the computational characteristics of elr data. out of several coding strategies available, the office of the u.s. national coordinator for health information technology has recently suggested incorporating logical observation identifiers names and codes (loinc) for laboratory orders and systemized nomenclature of medicineclinical terms (snomed ct) codes for laboratory results to standardize elr. methods we assessed the use of loinc and snomed ct codes in laboratory data reported to biosense, a near real-time national-level, electronic syndromic surveillance system, managed by the centers for disease control and prevention. elr data reported by 63 non-federal hospitals to biosense in 2011 were analyzed to examine loinc and snomed ct use in coding laboratory orders and results. we used relma software, developed and distributed by regenstrief institute inc for identifying loinc codes. results in 2011, a total of 14,028,774 laboratory test order or result reports from 821,108 individual patients were reported from the 63 hospitals in 14 states. since, by design the biosense program monitors a select set of syndromes mainly representing infectious conditions, 94% of the total reports were microbiology test orders or results. seventy-seven percent of all test orders (n = 10,776,494) used loinc codes. of all test results with at least one value either in observation identifier (obx3) or observation value (obx5) segments of their health level 7 (hl7) elr message (n = 12,313,952), 81% had only loinc codes, 0.1% had only snomed codes, 7% had both loinc and snomed codes, and 12% used no codes. in total, 1,428 unique loinc and 608 unique snomed codes were used to describe the results, and 805 unique loinc codes were used to describe the orders. of the 608 unique snomed codes, 111 (18.3%) did not have corresponding loinc codes. fifty-one (46%) of these 111 snomed codes could have been matched to corresponding loinc codes based on the concept. however, our search for matching loinc codes in relma for certain snomed concepts indicated that loinc does not have codes for select types of laboratory test results, particularly qualifier (such as reactive, negative, and resistant) or structural (labia, urethra, and vagina) concepts. conclusions our analysis showed that the use of snomed ct codes for laboratory test results by non-federal hospitals reporting laboratory data to biosense was extremely limited. these hospitals more frequently used loinc codes than snomed ct in reporting test results. we found that a large percentage of test results with snomed ct codes could be represented by loinc codes that exactly or closely match snomed ct codes. using loinc codes to report both test order and results in these databases could increase the availability and use of laboratory data in public health and surveillance activities. however, to increase the sensitivity of the coding further, a small number of tests could benefit by using loinc along with snomed ct codes. evaluation of use of syndromic surveillance case definitions that incorporate laboratory result information is required to determine if it improves syndromic surveillance performance for enhanced outbreak detection or improved situation awareness. keywords loinc; snomed; laboratory reporting; elr *sanjaya dhakal e-mail: hgj2@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e130, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a grid based approach to share public health surveillance applications the r example kailah davis*1 and julio facelli1, 2 1department of biomedical informatics, university of utah, salt lake city, ut, usa; 2center of high performance computing, university of utah, salt lake city, ut, usa objective this poster describes an approach which leverages grid technology for the epidemiological analysis of public health data. through a virtual environment, users, particularly epidemiologists, and others unfamiliar with the application, can perform on-demand powerful statistical analyses. introduction currently, there’s little effective communication and collaboration among public health departments. the lack of collaboration has resulted in more than 300 separate biosurveillance systems (1), which are disease specific, not integrated or interoperable, and may be duplicative (1). grid architecture is a promising methodology to aid in building a decentralized health surveillance infrastructure because it encourages an ecosystem development culture (2), which has the potential to increase collaboration and decrease duplications. methods this project had two major steps: creation and validation of the grid service. for the first step [creation of the service], we first determined the parameter set required to execute r from the command line. we then used the cagrid introduce toolkit (3) and grid rapid application virtualization interface (gravi) (4) to wrap the r command line interface into a grid service. the service was then deployed to the cagrid training grid. after deployment, the service was invoked using the r grid service client which was automatically created by introduce and gravi. our second step was aimed at validating the service by using using the grid service client to illustrate the working principles of r in a grid environment. for this illustration, we selected the article by hohle et al (5). in this article, the ‘surveillance’ package was developed to provide different algorithms for the detection of aberrations in routinely collected surveillance data. for validation purposes, only a subset of the analyses presented in the article, namely the farrington and cusum algorithms, were reproduced. using the grid web client, we uploaded the necessary data files for processing, as well as the rscript which was used to replicate the results of (5). the application then ran the r script on the execution machine; this machine had all the necessary r packages needed for the specific scenario. results the implementation of was validated by showing that the results of the original paper can be reproduced using gird based version of r. figure 1 shows the plots related to the steps described above; the plots illustrating the farrington and cusum algorithms are seen to be identical to that in (5). conclusions we demonstrated that it is possible to easily deploy applications for public health surveillance uses. we conclude that the techniques we used could be generalized to any application that has a command line interface. future work will be aimed creating a workflow to access data services and grid-enabled text processing and analytic tools. we believe that by providing a set of examples to demonstrate the benefit of this technology to public health surveillance infrastructure may provide insight that may lead to a better, more collaborative system of tools that will become the future of public health surveillance. fig 1. recreated plots keywords grid computing; public health grid; analytical service acknowledgments this work was supported by nlm training grant #t15lm007124 and cdc center of excellence for public health informatics # 1p01hk000069-10. references 1. subcommittee nba. improving the nation’s ability to detect and respond to 21st century urgent health threats: first report of the national biosurveillance advisory subcommittee. 2009. 2. facelli jc. an agenda for ultra-large-scale system research for global health informatics. acm sighit record. 2012;2(1):12-. 3. hastings s, oster s, langella s, ervin d, kurc t, saltz j. introduce: an open source toolkit for rapid development of strongly typed grid services. journal of grid computing. 2007;5(4):407-27. 4. chard k, tan w, boverhof j, madduri r, foster i, editors. wrap scientific applications as wsrf grid services using gravi. 2009: ieee. 5.höhle m, mazick a. aberration detection in r illustrated by danish mortality monitoring. biosurveillance: methods and case studies. 2010:215-37. *kailah davis e-mail: kailah.davis@utah.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e135, 2013 isds annual conference proceedings 2015. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2015 conference abstracts ensuring the week goes smoothly improving daily surveillance visualization roger morbey*1, alex j. elliot1, elizabeth buckingham-jeffery2 and gillian e. smith1 1public health england, birmingham, united kingdom; 2warwick university, coventry, united kingdom objective to develop smoothing techniques for daily syndromic surveillance data that allow for the easier identification of trends and unusual activity independent of day of the week and holiday effects. introduction real-time syndromic surveillance requires daily surveillance of a range of health data sources. most real-time data sources from health care systems exhibit large day of the week fluctuations as service provision and patient behaviour varies by day of the week. regular day of the week effects are further complicated by the occurrence of public holidays (usually 8 per year in england), which can limit the availability of certain services and affect patient behaviour. simple seven day moving averages fail to provide a smoothed trend around public holidays and can lead to false alarms or potentially delays in detection of outbreaks. methods data were used from four national syndromic surveillance systems (a non-emergency medical number, emergency department records, and information from family doctor in hours and unscheduled care consultations) coordinated by public health england. day of the week effects were modelled in the absence of public holidays by calculating the percentage of a week’s activity that occurs on each day of the week for a range of different syndromic indicators and syndromic surveillance systems. simple statistical t-tests were used to check for the significance of differences between days of the week. syndromic data were examined to test how public holidays impacted on day of the week effects. days immediately preceding and following holidays were also examined to identify any significant changes. differences between public holidays based on the time of year and the number of holidays within a single year were also examined. smoothing techniques for different syndromic systems were developed to remove artificial spikes around public holidays in simple seven day moving averages. results the impact of day of the week effects were found across all syndromic surveillance systems. unsurprisingly gp in hours data reported very little activity at weekends and on holidays, whilst gp unscheduled care and telephone help line data activity was roughly double at weekends and holidays. day of the week effects were much less clear in emergency department attendances but significant differences were still demonstrable. public holiday activity was similar to weekend activity in most cases, although activity on 25th december, christmas day was considerably less than other holidays. evidence was seen both of increased activity immediately prior to public holidays and on the first working day after a public holiday. seven day moving averages that are adjusted for bank holidays were shown to be effective in smoothing out artificial spikes in data. conclusions improved understanding of day of the week and public holiday effects enables improved modelling of baselines used in statistical detection algorithms, for instance 25th december should not be treated as having the same impact as other public holidays. future work will also consider condition-specific differences where the case mix varies by day of the week and during holidays. these improved smoothing techniques have enabled improved data visualization tools, enabling investigators to easily identify unusual activity during daily surveillance. example of improved smoothing for daily rates of herpes zoster consultations. keywords surveillance; visualisation; smoothing acknowledgments we acknowledge support from: royal college of emergency medicine, eds participating in the emergency department system (edsss), ascribe ltd and l2s2 ltd; ooh providers submitting data to the gpoohss and advanced heath & care; tpp and participating systmone practices and university of nottingham, clinrisk, emis and emis practices submitting data to the qsurveillance database; and nhs 111 and hscic for assistance and support in providing the anonymised call data that underpin the remote health advice syndromic surveillance system. we thank the phe real-time syndromic surveillance team for technical expertise. the authors received support from the national institute for health research health protection research unit in emergency preparedness and response. the views expressed are those of the authors and not necessarily those of the nhs, the nihr, the department of health or public health england. *roger morbey e-mail: roger.morbey@phe.gov.uk online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 8(1):e69, 2016 assessing the usage of dating sites and social networking sites in newly diagnosed hiv positive men who have sex with men (msm) in harris county, texas, 2014 najmus abdullah*, sudipa biswas, weilin zhou, hafeez rehman, salma khuwaja and raouf r. arafat the epidemiologic charateristics, healthcare associated and household transmission dynamics of evd outbreak in a south-southern city of nigeria olawunmi o. adeoye*1, endie waziri1, uchenna anebonam1, ifeoma nwaduito2, pauline green2, william komakech3, nnanna onyekwere2, gabriele poggensee1 and patrick m. nguku1 ebola virus disease surveillance and response preparedness in northern ghana martin n. adokiya*1 and john koku awoonor-williams2, 3 somebody’s poisoned the waterhole: aspca poison control center data to identify animal health risks kristen alldredge*1, 3, leah estberg1, cynthia johnson1, howard burkom2 and judy akkina1 minnesota e-health data repositories: assessing the status, readiness & opportunities to support population health bree allen*1, 2, karen soderberg1 and martin laventure1 evaluation of the measles case-based surveillance system in kaduna state (2010-2012) celestine a. ameh*2, muawiyyah b. sufiyan1, matthew jacob3, endie waziri2 and adebola t. olayinka1 integrating r into essence to enable custom data analysis and visualization jonathan arbaugh and wayne loschen* refocusing hepatitis c prevention through geographic viral load analyses ryan m. arnold*, biru yang, qi yu and raouf r. arafat a method for detecting and characterizing multiple outbreaks of infectious diseases john m. aronis*, nicholas e. millett, michael m. wagner, fuchiang tsui, ye ye and gregory f. cooper an open source quality assurance tool for hl7 v2 syndromic surveillance messages noam h. arzt* and srinath remala role of animal identification and registration in anthrax surveillance zviad asanishvili, tsira napetvaridze, otar parkadze, lasha avaliani, ioseb menteshashvili and jambul maglakelidze using syndromic surveillance to rapidly describe the early epidemiology of flakka use in florida, june 2014 – august 2015 david atrubin*, scott bowden and janet j. hamilton situational awareness of childhood immunization in kenya toluwani e. awoyele*2, 1, meenal pore1 and skyler speakman1 surveillance for mass gatherings: super bowl xlix in maricopa county, arizona, 2015 aurimar ayala*, vjollca berisha and kate goodin estimating flunearyou correlation to ilinet at different levels of participation eric v. bakota*, eunice r. santos and raouf r. arafat performance of early outbreak detection algorithms in public health surveillance from a simulation study gabriel bedubourg*1, 2 and yann le strat3 modernization of epi surveillance in kazakhstan: transition to risk assessment and real-time monitoring based on situational center zhandarbek bekshin2, aizhan esmagambetova2, stanislav kazakov3, alexry burdakov*1, damir kobzhasarov2 and andrey ukharov1 analysis of alternatives for combined and/or collaborative syndromic surveillance within dod and va robert e. bell*1, mark holodniy2 and julie a. pavlin3 utility of syndromic surveillance in detecting potential human exposures to rabies kelley bemis*, megan t. patel, mabel frias and demian christiansen disproportionate emergency room use as an indicator of community health kelley bemis*, samantha gray, megan t. patel and demian christiansen is there a need for one health surveillance (ohs)? john berezowski*1, judy akkina2, victor d. vilas3, katrina devore4, fernanda c. dórea5, céline dupuy6, melody j. maxwell3, vivek singh7, flavie vial1 and laura streichert4 classification and capture of work-related non-fatal injuries through a real-time syndromic surveillance system marija borjan* and margaret lumia role of influenza in ed visits and hospitalizations of adults over 65 years in france vanina bousquet*1, larissa vernier1, yann le strat1, isabelle bonmarin1, christophe leroy2, maurice raphaël3, gilles viudes5, andré de caffarelli4 and céline caserio-schönemann1 openness, transparency and equity in public health surveillance data sharing matthew brack*, michael edelstein, asha herten-crabb and david r. harper an ehars dashboard for state hiv surveillance elliott s. brannon*1, tera reynolds2, 3, sunyang fu2, 3, kristen harden3, dolorence okullo2, 3 and shreyas ramani2, 3 sharing situational awareness of the 2014-2015 highly-pathogenic avian influenza outbreak across government yandace k. brown* and teresa quitugua developing the scalable data integration for disease surveillance (sdids) platform david buckeridge*1, maxime lavigne1, kate zinszer2, anya okhmatovskaia1, samson tu3, csongor nyalus3, mark musen3, wilson lau4, lauren carroll4 and neil abernethy4 equine syndromic surveillance in colorado using veterinary laboratory test order data howard burkom*1, yevgeniy elbert1, jerrold dietz1, barbara powers2, cynthia johnson3, leah estberg3 and judy akkina3 enhanced mosquito surveillance for aedes spp. in santa cruz county, arizona mariana g. casal*1, 2, jose arriola3, steven erly1, 2, 4, nicolette dent1, 5, shelly jacobs3, kacey ernst4, kathleen walker4 and mary hayden6 impact assessment of a terrorist attack using syndromic surveillance, france, 2015 céline caserio-schönemann1, marc ruello1, delphine casamatta2, guillaume debaty3, pascal chansard4, magali bischoff5, carlos el khoury5, philippe pirard1, anne fouillet1 and hervé le perff2 impact of the 2015 july heat waves in france on heat-related causes céline caserio-schönemann*, anne fouillet, aymeric ung, manuel zurbaran, vanina bousquet, karine laaidi, mathilde pascal, sébastien denys, thierry cardoso and anne gallay leptospirosis in bangladesh: an urgent need for coordinated surveillance system shovon chakma1, 2 and sultan mahmood*1, 2 data exchange between immunization registry and disease surveillance system hwa-gan chang*1, griffin jacqueline2, hans proske2, megan meldrum1 and elizabeth rausch-phung1 social media analytics for post-disasters disease detection in the philippines lauren charles-smith*3, corinne ringholz1, benjamin brintz3, 2 and courtney d. corley3 towards influenza surveillance in military populations using novel and traditional sources lauren charles-smith*1, alexander rittel1, 2, umashanthi pavalanathan1, 3 and courtney d. corley1 ed visits related to marijuana exposures in the denver metropolitan area of colorado yushiuan chen*1, michele askenazi1, kathryn h. deyoung2, bernadette albanese1, lourdes w. yun2 and todd hockenberry1 washington state one health initiative: a model framework to put one health in action wayne clifford* using bayesian networks to assist decision-making in syndromic surveillance felipe j. colón-gonzález*1, iain lake1, gary barker2, gillian e. smith3, alex j. elliot3 and roger morbey3 surveillance strategies during low ebola transmission in a district in sierra leone allison m. connolly*, alyssa j. young, brooke mancuso, mary-anne hartley, adam hoar, guddu kaur, john mark esplana, laura fisher and anh-minh a tran day of week analysis of myocardial infarctions using essence-fl emergency department data allison b. culpepper*, david atrubin, janet j. hamilton and dongming cui key challenges for eradication of poliomyelitis in ukraine oksana cyganchuk* an improved ewma-based method for outbreak detection in multiple regions sesha k. dassanayaka* and joshua french evaluation of point of need diagnostic tests for use in california influenza outbreaks ashlynn daughton* and alina deshpande military and civilian disease outbreaks: a comparative analysis ashlynn daughton*2, nileena velappan2, esteban abeyta2, 1 and alina deshpande2 enhancing the biosense platform: findings from an essence and sas pilot project cassandra n. davis* french national health insurance information system for malaria surveillance francois delon*1, marc c. thellier2, aurélie mayet1, eric kendjo2, aïssata dia1, rémy michel1, gilles chatellier3 and guillaume desjeux4 evaluation of case detection of marijuana-related emergency department visits kathryn h. deyoung*1, robert beum1, yushiuan chen2, moises maravi1, lourdes w. yun1, michele askenazi2, judith shlay1 and arthur davidson1 hospital readmissions among the homeless population in albuquerque, new mexico victoria f. dirmyer* better, stronger, faster: why add fields to syndromic surveillance? new jersey, 2015 pinar erdogdu*, teresa hamby and stella tsai new master mapping reference table (mmrt) to assist icd-10 transition for syndromic surveillance brooke evans*1, peter hicks3, julie a. pavlin4, aaron kite-powell7, atar baer5, david j. swenson6, rebecca lampkins2, achala u. jayatilleke3 and laura streichert1 secondary data analysis of hiv/aids control programme data, enugu state, (2010-2013) chinyere c. ezeudu*, patrick m. nguku and abisola oladimeji evaluation of hiv/aids surveillance system (2010-2013) in enugu state april 2014 chinyere c. ezeudu*1, patrick m. nguku1, abisola oladimeji1 and olufunmilayo fawole2 triage notes in syndromic surveillance – a double edged sword zachary faigen*1, amy ising2, lana deyneka1 and anna e. waller2 eliciting disease data from wikipedia articles geoffrey fairchild*1, 3, lalindra de silva2, sara y. del valle1 and alberto m. segre3 one health in action: lyme disease veronica a. fialkowski*, erik foster, kim signs and mary grace stobierski evaluation of the michigan disease surveillance system for histoplasmosis reporting veronica a. fialkowski*, leigh m. tyndall snow, kimerbly signs and mary grace stobierski development of food hygiene surveillance system in plantation sector, sri lanka lahiru s. galgamuwa*1, devika iddawela1 and samath d. dharmaratne2, 3 from ebola to heroin; the use of ems data for near real time alerting and surviellance alexander garza* global disease monitoring and forecasting with wikipedia nicholas generous*, geoffrey fairchild, alina deshpande, sara y. del valle and reid priedhorsky alert-enabled application integrating data quality monitoring for multiple sources harold gil* and nicholas l. michaud evaluation of vaccine preventable diseases (measles and diphtheria) surveillance system delhi, india, 2013 kapil goel* validation of sys data to inform surveillance of health disparities in nebraska sandra gonzalez*1, 2, ashley newmyer1 and ming qu1 early estimation of the basic reproduction number using minimal outbreak data carl grafe* literature review of mental health and psychosocial aspects of ebola virus disease anna grigoryan*1, rebecca bitsko2, ha young lee3, barbara lopes-cardozo3 and ruth perou2 weather outlook: cloudy with a chance of…—classification of storm-related ed visits teresa hamby*, stella tsai, hui gu, gabrielle goodrow, jessie gleason and jerald fagliano a digital platform for local foodborne illness and outbreak surveillance jared b. hawkins*1, gaurav tuli1, sheryl kluberg1, 4, jenine harris2, john s. brownstein1, 3 and elaine nsoesie2 tick-borne encephalitis virus, coxiella burnetii & brucella spp. in milk, kazakhstan john hay1, christina farris2, phil elzer3, alexei andrushchenko4, sue hagius3, allen richards2 and timur ayazbayev4 emerging infectious diseases and health surveillance at u.s. air travel ports of entry: perspective from within the department of homeland security andrew hickey*, diana y. wong, tyann blessington, asher grady, chandra lesniak, sarah cheeseman barthel, scott teper, william bilado, jayme henenfent, tiana garrett, neil bonzagni, mark freese and teresa quitugua preliminary look into the icd9/10 transition impact on public health surveillance peter hicks1, julie a. pavlin6, atar baer2, david j. swenson*7, rebecca lampkins5, achala u. jayatilleke1, aaron kite-powell3, brooke evans4 and laura streichert4 an exploration of public events and alcohol related incidents briana a. holliday* mantle: an open source platform for one health biosurveillance and research andrew g. huff*1, 2 and toph allen1 augmenting surveillance to minimize the burden of norovirus-like illness in ontario: using telehealth ontario data to detect the onset of community activity stephanie l. hughes* and andrew papadopoulos product landscape of rapid diagnostic tests for viral hemorrhagic fever pathogens noah hull*2, andrew hickey1 and teresa quitugua1 what’s the buzz about arboviral disease syndromic surveillance? jenna iberg johnson* and christine scott-waldron regional syndromic surveillance data sharing workshops: process and early outcomes charlie ishikawa*1, katrina devore2, scott gordon3, mark sum3 and laura streichert2 knowledge management tools for the isds community of practice amy ising*1, wayne loschen2 and laura streichert3 injury surveillance with district health information system 2 (dhis2) achala u. jayatilleke*1, megha ganewatta1, pamod amarkoon1, roshan hewapathirana2 and achini jayatilleke3 how to effectively validate an hl7 syndromic surveillance interface jeffrey johnson*, brit colanter and marjorie richardson savsnet: collating veterinary electronic health records for research and surveillance philip h. jones*, alan d radford, peter-john m noble, fernando sánchez-vizcaíno, tarek menacere, bethaney heayns, susan bolan, maya wardeh, rosalind m gaskell and susan dawson motor vehicle crash (mvc) case definitions and how they impact mvc surveillance jennifer l. jones*, dennis m. falls, clifton a. barnett, amy ising and anna e. waller creating a universal data release policy across programs in a state health department ekaette joseph-isang* syndromic surveillance of emergency department visits for the 2015 special olympics emily kajita*, monica z. luarca, choiyuk chiang, han wu and bessie hwang washington’s methods for analytics interoperability and metrics (aim), approaches to data integration and dissemination in population health bryant thomas karras*1, ali h. mokdad2, adam aaseby3 and william lober2 electronic surveillance for injury prevention using a physician-operated system amir kimia1, 2, assaf landschaft3, maria jorina1, lois lee1, 2 and al ozonoff1, 2 surveillance for lyme disease in canada, 2009-2012 jules koffi*1, robbin lindsay3 and nicholas ogden2 resolving disconnected patient records to support patient care and population health jacob krive2, 3, 4, annamarie hendrickx*1 and terri godar1 evaluating syndromic surveillance systems iain lake1, felipe j. colón-gonzález*1, roger morbey2, alex j. elliot2, gillian e. smith2 and richard pebody3 three years of population-based cancer registration in kumasi: providing evidence for population-based cancer surveillance in ghana dennis o. laryea*1, 2, fred k. awittor2, cobbold sonia2 and kwame o. boadu3 impact of interventions on influenza a(h7n9) virus activity in live poultry markets eric h.y. lau*1, jun yuan2, kuibiao li2, connie leung3, zhicong yang2, caojun xie2, yufei liu2, biao di2, benjamin cowling1, xiaoping tang4, gabriel leung1, malik peiris1 and ming wang2 using health-seeking pattern to estimate disease burden from sentinel surveillance eric h.y. lau*, qiqi zhang, kin on kwok, irene o. wong, dennis k. ip and benjamin j. cowling increase in adverse health effects related to synthetic cannabinoid use royal k. law*1, josh schier1, colleen martin1, arthur chang1, amy wolkin1 and jay schauben2 using national health insurance claims data to supplement notifiable infectious disease surveillance system heeyoung lee1, kwan lee2, seon-ju yi*1, gichan park1, hwami kim1, soyoon min1, jee soo suh1, young-man kim1, soojung jo1 and daeun jeong1 whispers, the usgs-nwhc wildlife health information sharing partnership event reporting system julianna b. lenoch* evaluation of hepatitis c surveillance in washington state natalie linton* experience report: association between flow chart, electronic patient record and telephone monitoring in the success of fighting dengue feaver in the hospital and emergency services in são bernardo do campo, brazil andrea m. losacco*, eliana v. miranda, renata martello, karla possendoro, meire a. pinheiro and gabriela falchi data sharing across jurisdictions using essence federated queries wayne loschen*, rekha holtry and sheri lewis improving the value proposition of surveillance tools: innovative uses for va essence cynthia a. lucero-obusan*1, patricia schirmer1, gina oda1 and mark holodniy1, 2 interplay of socio-cultural and environmental factors on microbial contamination of food in samaru, kaduna state, nigeria beatty v. maikai* and mujtaba a. salman disease surveillance by private health providers in nigeria: a research proposal olusesan a. makinde*1 and clifford o. odimegwu2 towards automated risk-factor surveillance: using digital grocery purchasing data to measure socioeconomic inequalities in the impact of in-store price discounts on dietary choice hiroshi mamiya*, erica moodie, deepa jahagirdar and david buckeridge “koman i lé” : an online self-reported symptoms surveillance system in reunion island nadège marguerite1, pascal vilain*1, etienne sévin2, farid sahridji2 and laurent filleul1 building the road to a regional zoonoses strategy: a survey of zoonoses programs in the americas melody j. maxwell*1, 2, mary hofmeister freire de carvalho2 and victor del rio vilas2 towards self validation: progress and roadmap for automating the validation of biosense partner facilities travis mayo1, matthew dollacker1, corey cooper1 and sara imholte2 using health helpline mediated self-swabbing as a surveillance tool for influenza danielle mcgolrick*1, paul belanger2, allison maier2, harriet richardson1, kieran moore2, nino lombardi3 and anna majury1, 3 a bayesian hierarchical model for estimating influenza epidemic severity nicholas l. michaud* and jarad niemi cdcplot: an application for viewing weekly cdc mmwr disease count data nicholas l. michaud*1, aaron kite-powell2 and jarad niemi1 using laboratory data to aid early warning in prospective influenza mortality surveillance aye m. moa*, david j. muscatello, robin turner and c raina macintyre surveillance systems that include deprivation indices & social determinants of health kieran moore and paul belanger tracking trends in marginalization and deprivation across ontario with sdoh mapper kieran moore and paul belanger real-time surveillance of environmental and demographic data in ontario with phims kieran moore and paul belanger facilitating the sharing of patient information between health care providers kieran moore and paul belanger ensuring the week goes smoothly improving daily surveillance visualization roger morbey*1, alex j. elliot1, elizabeth buckingham-jeffery2 and gillian e. smith1 using scenarios and simulations to validate syndromic surveillance systems roger morbey*1, alex j. elliot1, gillian e. smith1, iain lake2 and felipe j. colón-gonzález2 the burden of seasonal respiratory pathogens on a new national telehealth system roger morbey*1, sally harcourt1, alex j. elliot1, richard pebody1, maria zambon1, john hutchison3, judith rutter2 and gillian e. smith1 identifying depression-related tweets from twitter for public health monitoring danielle mowery*1, hilary a. smith2, tyler cheney2, craig bryan2 and michael conway1 socio-demographic inequalities in hiv testing and prevalence among older adults in rural tanzania, 2013 angelina c. mtowa*1, annette a. gerritsen2, sally mtenga1, mary mwangome1 and eveline geubbels1 a timeliness study of disease surveillance data post elr implementation in houston kasimu muhetaer*, eunice r. santos, avi raju, kiley allred, biru yang and raouf r. arafat correlation between influenza-like illness reported by ilinet and nssp, kansas, 2014-2015 daniel j. neises* and farah naz surveillance of the naural foci of especially dangerous infections in southern ukraine zoya nekhoroshykh*, g.m. dzhurtubayeva, n.m. protsyshyna, n.v. pilipenko, s.v. pozdnyakov, n.a. popova and e.a. egorova surveillance of the naural foci of especially dangerous infections in sourthern ukraine zoya nekhoroshykh*, galina dzhurtubayeva, n.m. protsyshyna, s.v. pozdnyakov, n.v. pilipenko, n.a. popova and e.a. egorova a tool to improve communicable disease surveillance data candace m. noonan-toly*1, charles didonato2 and hwa-gan chang1 flea-borne rickettsiae in almaty oblast, kazakhstan talgat nurmakhanov1, yerlan sansyzbayev1, heidi st. john2, christina farris2 and allen richards2 denver county clostridium difficile trends and associated risk factors 2011-2013 anna d. oberste*1, kathryn h. deyoung1, helen johnston2, stephanie gravitz1, emily mccormick1 and arthur davidson1 evaluation of national influenza sentinel surveillance system in nigeria, jan-dec 2014 amaka p. onyiah*1, 2, muhammad s. balogun1, adebayo a. adedeji2 and patrick m. nguku1 ebola virus disease outbreak in lagos, nigeria; 2014: an epidemiological investigation folasade f. osundina*, abisola oladimeji, olufemi ajumobi, saheed gidado, adebola t. olayinka and patrick m. nguku cancer health disparities in southeastern wisconsin yi ou* methods to measure socio-economic inequalities in health for indian adolescents priyanka parmar*1, manu r. mathur1, georgios tsakos2 and richard g. watt2 investigating a syndromic surveillance signal with complimentary data systems hilary b. parton*, robert mathes, jasmine abdelnabi, lisa alleyne, andrea econome, robert fitzhenry, kristen forney, megan halbrook, stephanie ngai and don weiss use of electronic health records to determine the impact of ebola screening julie a. pavlin*1, gosia nowak2, aaron kite-powell3, lindsey beaman1 and timothy whitman4 prospective spatio-temporal and temporal cluster detection by salmonella serotype eric r. peterson*, vasudha reddy, haena waechter, lan li, kristen forney and sharon k. greene factors influencing the stability and quality of the french ed surveillance system isabelle pontais*, vanina bousquet, marc ruello, céline caserio-schönemann and anne fouillet monitoring media content about vaccines in the united states: data from the vaccine sentimeter guido a. powell*1, kate zinszer1, aman d. verma1, lawrence c. madoff3, chi bahk2, john s. brownstein4 and david buckeridge1 law, policy, and syndromic disease surveillance: a multi-site case study jonathan purtle*2, robert field1, esther chernak1, tom hipper1 and jillian nash1 susceptibility profile of drug-resistant streptococcus pneumoniae based on elr avi raju*, eunice r. santos, eric v. bakota, biru yang and raouf r. arafat predicting facility-level carbapenem-resistant enterobacteriaceae (cre) incidence based on social network measures michael j. ray*1, michael y. lin2 and william trick2 the public health community platform: implementing electronic case reporting marcus rennick*, scott gordon, monica huang, mark sum and paula soper an r script for assessment of data quality in the biosense locker database serena rezny* and stacey hoferka characterizing public health actions in response to syndromic surveillance alerts laura rivera1, rachel savage2, natasha crowcroft1, 2, laura rosella2, 1, li ye1, 2, shelly bolotin1, 2, wendy lou1 and ian johnson*1, 2 the impact of standardized decision support on syndromic surveillance in alberta laura rivera1, faiza habib3, ye li1, 2, rita k. biel3, rachel savage2, natasha crowcroft1, 2, laura rosella2, 1, shelly bolotin1, 2, david strong3, 4, christopher sikora3, 5 and ian johnson*1, 2 syndromic surveillance evaluation of influenza activity in at-risk sub-populations heather rubino*, janet j. hamilton, allison b. culpepper, hunter davis, david atrubin and melissa murray jordan epidemic situation in ukraine related to the quality of drinking water iryna rudenko* acute gastroenteritis: contribution of sos médecins network marc ruello*1, benjamin larras1, noémie fortin1, nathalie jourdan da-silva1, pascal chansard2, céline caserio-schönemann1, vanina bousquet1, anne fouillet1 and isabelle pontais1 which sections of electronic medical records are most relevant for real-time surveillance of influenza-like illness? dino p. rumoro1, shital c. shah1, marilyn m. hallock1, gillian s. gibbs*1, gordon m. trenholme1, michael j. waddell2 and joseph p. bernstein3 the impact of documentation style on influenza-like illness rates in the emergency department dino p. rumoro1, shital c. shah1, gillian s. gibbs*1, marilyn m. hallock1, gordon m. trenholme1, michael j. waddell2 and joseph p. bernstein3 natural language processing and technical challenges of influenza-like illness surveillance dino p. rumoro1, gillian s. gibbs*1, shital c. shah1, marilyn m. hallock1, gordon m. trenholme1, michael j. waddell2 and joseph p. bernstein3 one health e-surveillance for early detection of gastrointestinal disease outbreaks fernando sánchez-vizcaíno*1, barry rowlingson2, alan d radford1, alison hale2, emanuele giorgi2, sarah j o’brien3, susan dawson4, rosalind m gaskell1, philip h jones1, tarek menacere1, peter-john m noble4, maya wardeh1 and peter diggle2 data blindspots: high-tech disease surveillance misses the poor samuel v. scarpino*1, james g. scott2, rosalind eggo2, nedialko b. dimitrov2 and lauren a. meyers2, 1 a comparison of clinical surveillance systems in new york city lauren schreibstein*1, remle newton-dame1, katharine h. mcveigh1, sharon e. perlman1, lorna e. thorpe2, hannah mandel1 and michael buck1 monitoring and evaluation mechanism for multi-center capacity building gestational diabetes program for physicians in india megha sharma* avian flu, ebola, mers, and other emerging challenges for influenza surveillance practitioners alan siniscalchi2 and brooke evans*1 hit conformance testing: advancing syndromic surveillance system interoperability robert snelick and sheryl l. taylor* visualizing the local experience: hiv data to care tool lauren e. snyder*1, dean mcewen1, mark thrun2, 1 and arthur davidson1 extending an uncertainty taxonomy for suspected pneumonia case review brett r. south*1, 2, heidi s. kramer2, melissa castine1, danielle mowery1, 2, barbara jones2 and wendy chapman1, 2 comparison of exposure to risk factors for giardiasis among endemic and travel cases alexandra swirski*1, david pearl1, andrew peregrine1 and katarina pintar2 african one health e-surveillance initiative joy sylvester*1, herbert kazoora2, meeyoung park1, sheba gitta2, betiel h. haile1 and scott j. mcnabb1 strengthening community surveillance of ebola virus disease in sierra leone anhminh a. tran*, adam hoar, alyssa j. young, allison connolly, mary-anne hartley, samuel boland, brooke mancuso, guddu kaur, john esplana, erin polich and laura fisher surveillance of anthrax foci across pipeline constructions in georgia, 2003-2014 nikoloz tsertsvadze, lile malania, nato abazashvili, julieta manvelian, mariam broladze and paata imnadze situational awareness of health events using social media and the smart dashboard ming-hsiang tsou2, 3, 1, chin-te jung2, 3, 1 and michael peddecord*4, 3, 1 evaluation of legionellosis surveillance in michigan focusing on diagnostic testing leigh m. tyndall snow*1, 2, veronica a. fialkowski1, 2 and mary grace stobierski1 highway emergency response and accident mitigation service (heram) – a field report balaji utla*, dr. shailendra kumar b. hegde, dr. sri ranga prasad saride, dr. ramanuja chary kandaala, mr. sridhar upadhya and anukrati saxena enhancing biosurveillance specificity using praedico™, a next generation application alireza vahdatpour2, cynthia a. lucero-obusan1, chris lee2, gina oda1, patricia schirmer1, anosh mostaghimi1, farshid sedghi2, payam etminani2 and mark holodniy*1 biosense and violence: progress toward violence prevention using syndromic surveillance jennifer vahora* and stacey hoferka situational awareness for unfolding gastrointestinal outbreaks using historical data nileena velappan*, ashlynn daughton, esteban abeyta, geoffrey fairchild, william rosenberger and alina deshpande interest of prospective spatio-temporal analysis from ed data to detect unusual health events pascal vilain*, sébastien cossin and laurent filleul using syndromic surveillance to identify synthetic cannabinoids or marijuana adverse health events in virginia amanda wahnich* lessons learned from the transition to icd-10-cm: redefining syndromic surveillance case definitions for nc detect anna e. waller, katherine j. harmon* and amy ising automating ambulatory practice surveillance for influenza-like illness andrew walsh* enhancing epicenter data quality analytics with r andrew walsh* alcohol-related ed visits and ohio state football: putting the o-h in etoh kristen a. weiss* and andrew walsh enhancing syndromic surveillance at a local public health department jessica r. white* and kate goodin using syndromic surveillance to enhance arboviral surveillance in arizona jessica r. white*1, sara imholte2 and krystal collier2 evaluating the biosense syndrome for heat-related illness in maricopa county, arizona jessica r. white*, kate goodin and vjollca berisha sensitivity and specificity of the fever syndromes in biosense and essence caleb wiedeman* analysis of ed and ucc visits related to synthetic marijuana in essence-fl, 2010-2015 michael wiese*1 and charles r. clark2 comparison of air passenger travel volume data sources for biosurveillance diana y. wong*, teresa quitugua and julie waters a suggestion to improve timely feedback of infectious disease surveillance data at a provincial level in south korea seon-ju yi*, gichan park, hwami kim, soyoon min, jee soo suh, soojung jo, daeun jeong, young-man kim and heeyoung lee update on the cdc national syndromic surveillance program paula yoon and michael coletta* use of peripheral health units in low-transmission ebola virus disease surveillance alyssa j. young*, allison connolly, adam hoar, brooke mancuso, john mark esplana, guddu kaur, laura fisher, mary-anne hartley and anh-minh a tran place matters: revealing infectious disease disparities using area-based poverty kimberly yousey-hindes*1, sharon k. greene2, kelley bemis3 and kristen soto4 addressing health equity through data collection and linked disease surveillance iris zachary*1, jeannette jackson-thompson1, 2, 3, emily leary1 and eduardo simoes1, 2, 3 epizootology and molecular diagnosis of lumpy skin diesease among livestock in azerbaijan shalala k. zeynalova* exploring usability of school closure data for influenza-like illness surveillance yenlik zheteyeva*, hongjiang gao, jianrong shi and amra uzicanin efficient surveillance of childhood diabetes using electronic health record data victor w. zhong*1, jihad s. obeid2, jean b. craig2, emily r. pfaff1, joan thomas1, lindsay m. jaacks3, daniel p. beavers4, timothy s. carey1, jean m. lawrence5, dana dabelea6, richard f. hamman6, deborah a. bowlby2, catherine pihoker7, sharon h. saydah8 a layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts challenges and opportunities in routine time series analysis of surveillance data isabelle devaux*1, esther kissling2, gilles desve2, frantiska hruba1, francisco luquero2, chantal quinten1, joana gomes-diaz1, marta valenciano2 and denis coulombier1 1ecdc, solna, sweden; 2epiconcept, paris, france objective to discuss challenges and opportunities in the introduction of an automated approach for time series analysis (tsa) regarding epidemiological methodology for generation of hypotheses, steps to be performed and interpretation of outputs. introduction ecdc long term strategies for surveillance include analysis of trends of communicable disease of public health importance for european union countries to guide public health actions. the european surveillance system (tessy) holds data on 49 communicable diseases reported by 30 countries for at least the past five years. to simplify time related analysis using surveillance data, ecdc launched a project to enable descriptive and routine tsa without the need for complex programming. methods protocols for tessy data were developed specifying hypotheses to be tested, types and format of variables needed for tsa for several diseases, including vtec, and legionellosis. stata scripts were developed to comply with the basic steps of tsa, including data aggregation, data checking, data description, analysis of trends and seasonality, residual analysis, simple modelling and long-term forecasting. tsa steps were presented as successive tabs in a tsa dialogue box in stata. before using the stata tsa dialogue box, experts were offered a two-day training, and provided with an in-depth manual supporting use and interpretation of tsa outputs using the stata tsa dialogue box. results for vtec, it was possible to identify a small increase in the trend and a seasonal pattern in surveillance data with an estimate of the start of the increased risk for infection in the beginning of the summer season [1]. for legionellosis, an increasing trend in the number of reported cases was observed in 2010 [2]. feedback from the training showed that using the stata tsa dialogue box enables a quick exploratory analysis even by non-stata users who could focus on interpretation of results, rather than the programme writing. however, we emphasise that statistical knowledge of tsa as well as rigorous preparation of the datasets (including data quality checks) and generation of hypotheses, are essential to ensure appropriate analysis and meaningful interpretation of the results. conclusions using the stata tsa dialogue box saves time when performing rapid exploratory tsa of epidemiological data, avoiding the need for complex programming which is still needed for sophisticated tsa. results of exploratory tsa analysis can trigger new hypothesis, for more advanced and sophisticated tsa. the introduction of a new technology (stata tsa dialogue box) does not replace multi-disciplinary approach, knowledge and application of a methodological approach to tsa to produce meaningful results that can inform public health decision making. further testing and training will be performed to enhance simplicity before appropriate dissemination of the stata tsa dialogue box for a wider use. keywords surveillance; epidemiology; statistical model; data analysis; software tool acknowledgments ecdc experts in food and water-borne diseases (angela lahuerta-marin, taina niskanen, johanna takkinen, therese westrell), and legionnaires’ disease (julien beaute). references [1] joana gomes dias, franti!ka hrubá, chantal quinten, bruno ciancio, isabelle devaux, taina niskanen, therese westrell, angela lahuertamarin, johanna takkinen. time-series analysis of vtec/stec surveillance data, 2008–2010. poster to be presented in escaide (www.escaide.org) 24-26 october 2012. [2] julien beaute, birgita de jong. time series analysis of communityacquired legionnaires’ disease in europe. poster to be presented in escaide (www.escaide.org) 24-26 october 2012. *isabelle devaux e-mail: isabelle.devaux@ecdc.europa.eu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e182, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts surveillance for radiation-related exposures reported to the national poison data system royal k. law*1, colleen martin1, alvin bronstein2, arthur chang1 and joshua schier1 1centers for disease control and prevention, chamblee, ga, usa; 2american association of poison control centers, alexandria, va, usa objective to describe radiation-related exposures of potential public health significance reported to the national poison data system (npds). introduction for radiological incidents, collecting surveillance data can identify radiation-related public health significant incidents quickly and enable public health officials to describe the characteristics of the affected population and the magnitude of the health impact which in turn can inform public health decision-making. a survey administered by the council of state and territorial epidemiologists (cste) to state health departments in 2010 assessed the extent of state-level planning for surveillance of radiation-related exposures and incidents: 70%–84% of states reported minimal or no planning completed. one data source for surveillance of radiological exposures and illnesses is regional poison centers (pcs), who receive information requests and reported exposures from healthcare providers and the public. since 2010, the centers for disease control and prevention (cdc) and the american association of poison control centers (aapcc) have conducted ongoing surveillance for exposures to radiation and radioactive materials reported from all 57 united states (us) pcs to npds, a web-based, national pc reporting database and surveillance system. methods we collaborated with the american association of poison control centers (aapcc), poisindex® and thomson reuters healthcare to develop an improved coding system for tracking radiation-related exposures reported to us pcs during 2011 and trained pc staff on its usage. we reviewed npds data from 1 september 2010 – 30 june 2012 for reported exposures to pharmaceutical or nonpharmaceutical radionuclides; ionizing radiation; radiological or nuclear weapons; or x-ray, alpha, beta, gamma, or neutron radiation. cdc medical toxicology and epidemiology staff reviewed each reported exposure to determine whether it was of potential public health concern (e.g. exposures associated with an ongoing public health emergency, several reported exposures clustered in space and time). when further information was needed to classify the potential public health importance of a call, cdc and aapcc staff contacted the regional pc where each call originated. when exposures were spatially and temporally clustered, we reviewed news stories in the public media for evidence of an associated radiation incident. results of 419 exposures reported during the study period, 25 were associated with a radiation-related incident. of these, 4 were related to an exposure to x-ray radiation from an industrial radiography incident, 11 were related to a transportation accident involving potential contamination with radioactive material, and 10 were related to the fukushima daiichi japan nuclear reactor disaster. public health, hazardous materials, or hospital radiation safety staff were involved in responding to each of these events. we also identified 26 reported exposures associated with a regional radiation anti-terrorism exercise. the reported exposures were followed-up and removed from analysis once we determined they were part of the exercise. the remaining (n=368; 88%) were either requests for information, confirmed non-exposures, or exposures deemed unrelated or non-significant. conclusions the capability to monitor selfor clinician-reported exposures to radiation and radioactive materials is available in npds for state and local public health use in collaboration with their regional pc and may improve public health capacity to identify and respond to radiological emergencies. next steps include testing the system’s capability to accurately classify and rapidly respond to a cluster of calls to pcs reporting radiation exposures associated with a “dirty bomb” exercise during july, 2012. keywords surveillance; poison center; radiation references council of state and territorial epidemiologists. the status of state-level radiation emergency preparedness and response capabilities, 2010. available at: http://www.cste.org/webpdfs/2010raditionreport.pdf. accessed july 19, 2012. *royal k. law e-mail: hua1@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e96, 2013 crappdf.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 92 (page number not for citation purposes) isds 2013 conference abstracts antibiotic sensitivity and clinical outcome for methicillin resistant staphylococcus aureus dennis o. laryea*1, yaw a. amoako2 and joyce asamoah1 1public health unit, komfo anokye teaching hospital, kumasi, ghana; 2department of medicine, komfo anokye teaching hospital, kumasi, ghana � �� �� �� � � �� �� �� � objective �������� � ����� ��������� ����� ��� ���������������� ���� ������ ��� �� �� ���� �������������������� ���� introduction �� ���� �������� �� �� ���� ���������������������������� ����� ���� ���� �������������������� �� � ���� ���� ���� ��� ��!�������"�� ������������������ ����� ����� ������� ��������� ���� ������� ��� ��"���������������������� �������������"�� ������������������� �� ���� ��"��� �� �������"���� ���������!�#������������������� ���� �������������������� ���� ��� � �������� �� ����� ��� ���"���� � ����!�$����� ����� ����"����� �������� ����"�%����&��������� �� ���"������������������������ ������ ������� ����!�$ ������ �����"� ��������� ����������������������� ��������%����!��� ��������� ��� � ���� �����"�������������� � � ��"���������� �������� ����������������� ��"� ������� �� �� !������������� �� ��������� ��� � ����� ����� ������ � ����'���� ��������������������� �"�� ���� ������ �� ����������!� ������������ ��������������� ��������� ���������������� ����� � �� ������ � �������������� ����"����� ����!�(�� ����������� ��� � �� ����� ��������������������������������"�)���� � ����%����� ���� �� �� �� ������������� �������� �������� ��� ������ ��� ����������� ���� � �������� ��� ������� ����� ��� �������������! methods (������� ��� ����� ����������������������������������� � ��� *��������+����������"�)���� � ��*��)�����*������%���������� ,������� ��-��������./00��� � ������������� ���� ���� ����� ��� ��� ������� �����������!�$��*��)&�1 ��� ������ ����� ���� ���� � �������� ������� ����� �������������� � ��"� ������ � �������� ���� �������� ������������ ������� ������������ ����������!�2�� ������ ���� ������� �� ��� �� �� ������������ ���������������� �� ���� ���� ������������ � � ����������� ���������������� ��� ���!�3���� ��� ������"��� ��� �� ������ ������ ������������� ������! results �� � � ��������� ��������45���������������� �������� �������� � � ��"� ��� ����� ���������������� !�������6��� ����������� ������ ��75.� �89!:;��� ���� ���)���� � ������� ��� ����??!:;���������!�3�������� ���������������� ������ ������,������&� 2�������&������&�,��������,� �!�������� ���������� ������������ ������������������!�������� ��������"�� � ��-��������� ���������� � � ��� �0/�����������! @ ���� ��� ����������� ����������������� � ����������!��� � � ����95��:9!8;�������� ������� � ��������� ���!�(������ ���� ������ �������a!8;���������!�������6��� �������� � ��� ��������� ���� ��#�����������a:!?;b��c84�!������� ���� ��������� �� �������� ��� � �� ��=����� � ������a8!.;b��c�.0������%�� ��������98!.;b��c.?�!� (����� ���� �� ����� ���� ����� ��� ������5:��95!a;�������!����� �������� ��� ������ ��������� ����� ����"������������� ����� ���� �� ��"��5?!:;b��c5:�� � ��������������������:!?;������%�� ��� �� ��� ����:!?;����� ���� ��������������"�����!�������6��� ����������� �����������"����� ����� ��� �� � ����� ����������������"�9������� �=������ � � ���� �����0.!9;�! conclusions ��������� ����������� �� ����� ��"������ � ���������������� ��� ������������� ��������� � � �!�1�������� ������� �������"����� � � �� �� ������"����������������������������*�����!�� ���"������"���� ���� ������������������������� ����������������*��)������"� ��� ������&������ ����� ����� ������� � � ������ ��������������� ��� ����� "���� ��������� ������������!� ��������� �������� ���� �� ������������ �������� ���������������� ���� ���"���� �������������"��"������������� �� �� ��� ����+�!������� ���� ��� �������� ����� ��������� �"� �� �����"���������������������� ����������������� ���3���� � �>�� !�(��� ������������� ������� ����������� �������������������������"��������������"���� ����� ����! keywords ����b�%����b������ ��� �b������ ���� acknowledgments (�� ���� ����+�� ��"�� ���� ������� ���*��������+����������"�)��� �� � �d�� ���)�� ��>�� ����� ����������� �"�� ����� ��� references 0!� (����� �+�&� @b� )������&� eb� %��"���&� -@b� � ���&� �b� ��� ��&� �b� @���+��� ��"���-�� �� �)���� � ������=������ ��@����������� � ���������� ���� �������� �� �� ���� ��������������f�d��������)��� �� � �g� ������� �����6������+�2�� ���$���� ����=�� �� �����)���� � � h������� �"��.///b�.0�00�f�4.5�4.4 .!� �������+&��b�@������ &,�ib�d�� �&���b�)���+&�-�b���������,�!&�@b� *�� &�*ib�d�""��*��"&��3&��@�b�����d� �����&�i�!�>������� ����� ��� ����������� ���� �������� �� �� ���� ������������������?����� �� � ���)���� � ������ �����$� ���� ����������.//:b�05:��9�f�50/��50: ?!� ����������&��������&�3� ��%&��������@��&�%� � ����*&������ �� ������!�d���� ���������� ���� �������� �� �� ���� ��������������� ����� �� ������������ ������ � ������� ����> ���d������!�$������,����� �������� �7����� ��� ���<�.//?b�.0f5a�80� �f�� !�6��!��"� � ! ���j.//?�.0�0�5a�:?0: *dennis o. laryea e-mail: denola@live.com� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e11, 2014 project 1 the last mile: using fax machines to exchange data between clinicians and public health 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 the last mile: using fax machines to exchange data between clinicians and public health stephen m. downs, md, ms, 1,2 vibha anand, phd, 1.2 , meena sheley, 1 bs, shaun j. grannis, md, ms 2 1 children’s health services research, indiana university 2 regenstrief institute, inc. indianapolis, in abstract there is overlap in a wide range of activities to support both public health and clinical care. examples include immunization registries (ir), newborn screening (nbs), disease reporting, lead screening programs, and more. health information exchanges create an opportunity to share data between the clinical and public health environments, providing decision support to clinicians and surveillance and tracking information to public health. we developed mechanisms to support two-way communication between clinicians in the indiana health information exchange (ihie) and the indiana state department of health (isdh). this paper describes challenges we faced and design decisions made to overcome them. we developed systems to help clinicians communicate with the isdh ir and with the nbs program. challenges included (1) a minority of clinicians who use electronic health records (ehr), (2) lack of universal patient identifiers, (3) identifying physicians responsible for newborns, and (4) designing around complex security policies and firewalls. to communicate electronically with clinicians without ehrs, we utilize their fax machines. our rule-based decision support system generates tailored forms that are automatically faxed to clinicians. the forms include coded input fields that capture data for automatic transfer into the ihie when they are faxed back. because the same individuals have different identifiers, and newborns’ names change, it is challenging to match patients across systems. we use a stochastic matching algorithm to link records. we scan electronic clinical messages (hl7 format) coming into ihie to find clinicians responsible for newborns. we have designed an architecture to link ihie, isdh, and our systems. key words: newborn, screening, informatics, public health, immunization, registry health information exchange introduction a major challenge for public health informatics is facilitating the exchange of information between public health and clinical care. data in public health information systems often come the last mile: using fax machines to exchange data between clinicians and public health 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 from forms filled out by hand, which are later computer-coded. even when reporting is electronic, initial data entry is typically still manual. as a result reportable diseases and conditions may be underreported. 1 data need to flow automatically to public health from clinical environments. when these data are appropriately compiled by public health information systems, they can allow more rapid and accurate assessments and disease control responses, as well as the formulation of improved clinical guidelines and interventions. conversely, automated presentation to clinicians of prevention guidelines has been shown to improve clinical care. 2 there are numerous ways in which the skills and activities of the public health community could benefit clinical care. electronic information sharing is a means by which we believe public health and clinical care activities can be integrated. 3 this is especially important in children, who undergo a series of preventive and therapeutic health interventions and activities that are relevant to public health, including newborn screening, immunizations, and lead screening. typically, each activity includes collection and submission of data to a dedicated public health system. 4 programs that can integrate decision support and data capture into the clinical workflow are likely to improve these shared functions. for example, newborn screening programs improve outcomes and are among the most costeffective (even cost saving) strategies in the healthcare system. 5 effective newborn screening programs consist of not only the screening tests, but also confirmation and assurance of appropriate treatment and follow-up of identified conditions. primary care physicians play an important role in the success of the newborn screening system and should have appropriate ongoing involvement in follow-up and tracking efforts. most pediatricians believe that primary care physicians should be responsible for informing families about a positive newborn screen, arranging confirmatory testing, and coordinating subspecialty referral. however, many do not feel competent to discuss conditions included in newborn screening panels, 6 which emphasize the need for decision support. likewise, immunizations are one of the most successful and effective public health tools for preventing disease, disability, and death from preventable disease. 7 the american academy of pediatrics (aap) and the advisory committee on immunization practices (acip) of the centers for disease control and prevention (cdc) have provided national standard guidelines for immunization and have constantly updated them since 1997. 8 to maximize vaccination rates, immunization registries have been developed in most states to track the complex series of vaccines that may be delivered by a variety of providers. however, registries never really reach their potential unless they are utilized by the vast majority of clinicians who provide immunizations. while 75% of children have vaccine data in registries, and registries are widespread and capable of sharing data, only a minority of providers routinely access them, 9 largely because only 3% of pediatricians use electronic medical records (emr) that are both fully functional and pediatric-appropriate. 10 this may be because so few systems are specifically designed with pediatric needs in mind. even among those who have an emr, most of their systems do not provide clinical decision support. one survey of 1000 primary care pediatricians 11 found only 21% used electronic health records. among those that had emr, a paltry 49% have preventive services prompts, and only 33% provided alerts for abnormal results. pediatricians who did not use emrs cited two the last mile: using fax machines to exchange data between clinicians and public health 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 significant barriers to emr implementation. the first, cost, was identified by 94% and was especially problematic for small practices. interestingly, 58% perceived no potential improvement in care from an emr. clearly there is a need for electronic communications between public health systems and clinicians. moreover, clinicians would benefit from decision support in the areas of immunization forecasting and management of conditions detected by newborn screening. these needs are reflected in the “meaningful use” rules set forth by the office of the national coordinator for health information technology. 12 however, until there is more widespread adoption of fully functional emr technology in pediatrics practices, other strategies of connecting public health to pediatric practitioners will be needed. in indiana, we are leveraging a statewide health information exchange 13 to explore methods for connecting public health systems and decision support to clinicians who may have no technology more elaborate that a fax machine. methods our approach builds on two initiatives – the indiana health information exchange (ihie) and the child health improvement through computer automation system (chica). by monitoring messages entering ihie from the state health department and from the health systems in the exchange, we are able to link clinicians with public health. using rule based logic, our system can deliver decision support to both clinicians and the health department. finally, using a tailored scannable paper as an interface with optical character recognition (ocr) and optical mark recognition (omr), we can capture coded data from clinicians with nothing more than a fax machine. ihie and the indiana network for patient care the indiana health information exchange operates the nation’s largest health information exchange, partnering with communities throughout indiana. 14 ihie connects hospitals, rehabilitation centers, long term care facilities, laboratories, imaging centers, clinics, community health centers and other healthcare organizations. data are transmitted from these sources by hl7 messaging and stored in separate files within one data repository known as the indiana network for patient care (inpc). 13 the inpc receives data from 70 hospitals and 18,000 physicians. it contains data from over 11 million patients with almost 24 million patient registrations and 3.8 billion clinical results. 14 ihie operates a results delivery system, docs4docs, 15 which has delivered over 77 million clinical results to participating clinicians. these results can be delivered to an emr, to a secure electronic mailbox or to a fax machine. chica and adaptive turnaround documents to leverage the health information exchange and the results delivery system, we needed a decision support engine that could interpret inbound hl7 messages from different sources and generate appropriate information to deliver to the health department and the appropriate clinician. we started with the framework of the child health improvement through computer automation (chica) system. 16 the last mile: using fax machines to exchange data between clinicians and public health 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 chica is a clinical decision support system for pediatric primary care that has been running in pediatric clinics in indiana for seven years. the system has an hl7 message processor that allows it to communicate with its underlying emr, the regenstrief medical record system (rmrs). it is built on an open source medical record framework known as openmrs. 17, 18 chica has a logic module that interprets rules encoded in arden syntax. 19 these rules (or medical logic modules, mlms) can extract and interpret data in the underlying medical record and write new data into the record. one of chica’s most unusual features is its user interface, which consist of tailored, scannable forms printed on paper. we refer to these forms as adaptive turn around documents (atad). atad forms are printed and scanned using the teleform desktop suite version 10.x (www.verity.com) that includes an automerge publisher, an ocr/omr reader and a verifier. the automerge publisher populates a form template (to be completed by the patient or physician) with patient specific questions or prompts that have been generated by the system with arden mlms. the forms are then printed by a standard laser printer. data entry is achieved by scanning a patient questionnaire form (completed by the family in the waiting room) or the physician worksheet using a standard document scanner. the system also stores a tiff image of the scanned forms. the teleform reader interprets the handwritten numbers and checkbox responses. enhancing the state newborn screening program the atad model allows data to be captured from facsimile (fax) documents as well as scanned documents. with this capability, we wanted to test the feasibility of using atads to link newborn screening (nbs) programs, subspecialists and the medical home. the system is intended to enhance the nbs process in three ways. first, it provides just-in-time information to the medical home (physicians and families). second, it can prevent missed opportunities to screen by identifying children with medical encounters anywhere in the state for whom no nbs result is known. finally, it would facilitate long term tracking of children with identified conditions. the approach utilizes ihie, docs4docs and chica in the following steps. first, we expanded the basic chica architecture with a fax server (faxpress 2500, opentext, bellevue, wa, faxsolutions.opentext.com), a device that enables us to send and receive faxes from any device on the network. thus, the fax server can receive a completed atad from a fax machine anywhere and render it as a tiff image that the teleform software can interpret just as it does the scanned images in the basic chica implementation. the newborn screening laboratory, under contract with the isdh, conducts metabolic screening on dried blood spots, compiles the results, combines them with newborn hearing screening results, and sends them to isdh. we have worked with isdh to establish an hl7 version 2.x standard for packaging the results in messages that can be sent to the inpc. these hl7 messages are captured by our new born screening system (nbss), a software instantiation similar to chica. the hl7 message is parsed, and a stochastic matching algorithm (see below) matches the message against records in the openmrs database. if the result matches an existing patient, the http://www.verity.com/ the last mile: using fax machines to exchange data between clinicians and public health 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 record is appended. if it is a new patient, a new record is created. early manual testing of this stochastic algorithm show it to be highly reliable, and the production system does not require manual checking. often, duplicate hl7 messages are sent. our system recognizes and eliminates these in two steps. first, a numeric hash function is applied to each hl7 message. then the resulting hash value is compared among messages, and exact duplicates are eliminated. when an hl7 message arrives, the system invokes the arden syntax rules to interpret the nbs results contained in the message. if the results are abnormal and require further diagnosis and treatment or if the specimen is inadequate and the screen needs to be repeated, chica generates an atad. (figure 1) these atads incorporate the american college of medical genetics action sheets. 20 these sheets provide information about the condition, confirmatory diagnosis, and emergency management. among the biggest challenges nbs programs face is the identification of the physician who has responsibility for an identified child. another challenge is finding children in the community who have not been screened. to meet these challenges, the system parses all incoming hl7 messages related to any child under the age of one month anywhere in the inpc. these may include admission or discharge messages, laboratory result messages, etc. each of these messages is parsed and matched against our database of nbs results. if the child is identified in the system, the arden rules determine if there was a normal newborn screen result in the database. if so, no further action is needed. if there is an abnormal or missing result, an appropriate atad is generated. matching records presented a challenge because data identifying newborns is highly variable among systems and across time. for example, at birth a child’s name may be recorded as “baby boy smith” because his mother’s name is smith. however, in a week’s time, the name may be “matthew jones, jr.,” after his father. to match such variable records across systems requires a matching algorithm that is more sophisticated than most. we utilize a probabilistic matching algorithm developed in our group. 21 the matching algorithm is based on the information theory concept of entropy and utilizes patient identifying data in the patient identification (pid) and next of kin (nk1) segments of the hl7 messages. the pid segment includes information about the patient such as name, date of birth, sex, race, address and phone number. the nk1 segment contains similar information about the baby’s mother. our work shows that comparing these using a statistical algorithm produces highly accurate matches even when some data are missing or changed. 21 the last mile: using fax machines to exchange data between clinicians and public health 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 figure 1: an example of an adaptive turnaround document about a child with an abnormal newborn screen delivered to a primary care clinician using the docs4docs system jennifer d. patient dob: 14 may 2007 newborn screening alert: elevated c8 with lesser elevations of c6 and c10 acylcarnitine suggestive of medium-chain acyl-coa dehydrogenase (mcad) deficiency condition description: mcad deficiency is a fatty acid oxidation (fao) disorder. fao occurs during prolonged fasting and/or periods of increased energy demands (fever, stress) when energy production relies increasingly on fat metabolism. in an fao disorder, fatty acids and potentially toxic derivatives accumulate because of a deficiency in one of the mitochondrial fao enzymes. medical emergency take the following immediate actions: contact family to inform them of the newborn screening result and ascertain clinical status (poor feeding, vomiting, lethargy). consult with pediatric metabolic specialist. evaluate the newborn (poor feeding, lethargy, hypotonia, hepatomegaly). if signs are present or infant is ill, initiate emergency treatment with iv glucose. transport to hospital for further treatment in consultation with metabolic specialist. if infant is normal initiate timely confirmatory/diagnostic testing, as recommended by specialist. educate family about need for infant to avoid fasting. even if mildly ill, immediate treatment with iv glucose is needed. report findings to newborn screening program. diagnostic evaluation: plasma acylcarnitine analysis will show elevated octanoylcarnitine (c8). urine acylglycine will show elevated hexanoylglycine. diagnosis is confirmed by mutation analysis of the mcad gene. please check all of the following that apply: [ ] family contacted [ ] newborn clinical status assessed [ ] problems (poor feeding, vomiting, lethargy, hypotonia, hepatomegaly) [ ] treated with iv glucose [ ] infant stable [ ] family provided attached educational materials diagnostic evaluation [ ] plasma acylcarnitine sent [ ] referral made to metabolic center [ ] family could not be contacted [ ] this is not my patient the last mile: using fax machines to exchange data between clinicians and public health 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 linking practices to the immunization registry a second application of the chica model to link clinicians to public health systems is the chica immunization assistant (chia). chia helps facilitate participation in an immunization information system (iis or registry) by clinicians who lack emr systems or access to the internet (because of technical or time constraints). as with the nbs module, the concept is to provide an interface that requires minimal technology – a fax machine – and will fit into the clinic workflow. the isdh has a well developed statewide iis known as the children and hoosier immunization registry project (chirp). chirp offers a web application that allows enrolled users to search for patients, view vaccination records, and add or edit patient records and vaccination records. (https://chirp.in.gov) chirp captures immunization data from all the indiana health departments and from medicaid claims. unfortunately, use of chirp by pediatric practitioners has not been high. chirp provides an hl7 interface for ehr systems. 22 however, because of the low penetration of comprehensive ehrs among pediatricians, 10 a new solution was needed. chia serves as a “low tech” front end to chirp. equipment required by the practice to use chia will be only a fax machine and scannable forms. in order for a physician to enroll a patient through chia, a form is completed and faxed. this form has spaces for the patient’s name, date of birth, mother’s name, address, phone number, social security number, and membership number in the us department of agriculture women, infants and children (wic) program. the clinic completes whatever fields on the form are available and faxes it to the chia toll-free number. the fax is received by the chia fax server, and the coded fields from the faxed form are extracted and read using ocr by teleform into the system’s data tables. ocr accuracy is heavily dependent on handwriting, fax quality, and whether the field is numeric or alpha numeric. the system is in an early pilot phase, and several prototypes and revisions will be required to achieve appropriate settings for the software which has sensitivity and specificity settings that can be changed. once the data are extracted from the form, chia generates an hl7 vaccination record query (vxq) message that is sent to chirp. in our implementation, hl7 messages are passed through the indiana network for patient care (inpc), which maintains a virtual private network (vpn) connection to chirp. the vxq message contains patient identifying information. chirp matches this information against records in the registry and returns the vaccination record via an hl7 vaccine query response (vxr) or returns an hl7 response to vaccination query with multiple patient matches (vxx) message containing possible patient matches. in the case that no match is found, chia will create a record in chirp, using an unsolicited vaccination record (vxu) message. when more than one match is found, the clinician will be required to disambiguate. when a patient match is achieved, chirp responds by faxing a form back to the clinician (figure 2). this form contains a unique identifier, generated by chia, which is encoded in a bar code. this allows chia to recognize the form and the patient to whom it refers when it is faxed back. the form provides the vaccine data available in chirp and a recommendation for what the last mile: using fax machines to exchange data between clinicians and public health 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 vaccines should be given on that date. in addition, the form allows the clinician to record past vaccination dates that are missing from chirp and to indicate, by checking boxes, which vaccines were given. once these forms are completed, they are faxed to the chia toll-free number. the data are transferred to the chirp database. the form remains for the clinician to use as part of the paper medical record. this obviates the need for duplicate data entry. page 1 of fax the last mile: using fax machines to exchange data between clinicians and public health 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 figure 2: the chia immunization form used to transfer immunization data to and from the immunization registry by machine readable fax. pages 1 and 2 shown at subsequent encounters, the clinician can fax any of the existing paper forms completed for this patient because they all have the bar code that identifies the patient. faxing a form will trigger the chia system to query chirp with another vxq and capture the data from the registry. chia will fax back a new immunization form with any new vaccines and new recommendations. results the project is in its preliminary, technical development stage. described below are important milestones achieved to date as well as specific technical challenges and their solutions. the last mile: using fax machines to exchange data between clinicians and public health 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 hl7 transmission an early achievement was the establishment of a standard hl7 stream carrying newborn screening lab results. the output of the newborn screening laboratory consists of a set of proprietary results codes in a “pipe-delimited” file format. these are converted at the isdh into standard hl7 version 2.x messages that are captured by our system. the results are still in a proprietary coding system but will, in time, be converted to a loinc standard. 23, 24 an additional step was creating a filter that captures all hl7 messages entering the inpc for those whose patient identification (pid) segments show an age of 1 month or younger. these messages are packaged along with provider information (pv1 segments) and next of kin (nk1 segments) into an hl7 message that is passed on to the newborn screening system. we have demonstrated the process of parsing newborn screening lab messages, matching them against messages from the inpc, generating atads. in an initial pilot test of the matching algorithm, we parsed 100,785 messages from the newborn screening laboratory. in the same timeframe, there were 2,561 hl7 messages entering the inpc for children of aged 1 month or younger. thus, about 2.5% of newborns in indiana will have a subsequent healthcare visit that appears in the inpc. of the 2,561 inpc messages, 2,243 (88%) could be linked to the messages from the newborn screening lab. this left 318 (12%) of messages from the inpc that could not be tied to a newborn screening result. on manual review of these, most were “junk” messages that did not contain real patient data. many were test messages or other information from external sources that have nothing to do with patients. however a small number (99) were patients who had not been screened. all but one of these were in neonatal intensive care units, a setting in which newborn screening can be missed. 25 crossing domains and security policies in order to deliver the messages to clinician participating in ihie, we had to produce the atads and send them through the results delivery system, docs4docs. to do this the atads had to be converted to portable document format (pdf), the only image format the system handles. this required additional software to make the translation. the forms were then placed in the obx segment of an hl7 message and sent back to the inpc to be picked up by the docs4docs server and delivered. establishing servers in secure environment and establishing the interfaces with external systems (hl7 input and output feeds, fax server, teleform) represented a significant technical hurdle. figure 3 shows a schematic of the processes involved in the bringing the teleform functionality, the chica rules engine, ihie and the docs4docs services into one working system. although the technical steps were facilitated by using health it industry standards whenever feasible, negotiating each entities security policies required substantial effort. handling paper in an electronic environment we also found that the docs4docs results delivery system adds a header and footer to the images it delivers. the result is shrinkage of the image. because the teleforms software has to recognize bar codes and other markers on the forms, this posed a challenge. with experimentation and adoption of specific barcode formats, we found that the software could tolerate an image reduced by 15% or less and still scan reliably. the last mile: using fax machines to exchange data between clinicians and public health 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 when atads are completed and faxed back, the quality of the fax machine comes into play. low quality machines can skew and distort the imagines, making machine recognition of the form and interpretation of the coded fields impossible. knowing quality of forms we get back from the clinicians in the inpc will have to wait until full deployment of the system. however, manual review of critical forms may still be necessary. in our pilot program, data managers in the children’s health services research section at indiana university manually check faxes that are not interpretable by the ocr software. fax server ihie domain chica production service teleforms server hl7 messages from inpc & isdh rta application software create atd: -parse hl7 -create xml atd using arden rules database teleform auto merge publisher convert atd: tiff to pdf t iff hl7 exporter -construct hl7 with encoded atd attached pdf teleform reader hl7 to docs4docs 2 1 3 4 5 t iff x m l physician completes form and faxes back 6 7 archive and send to teleform reader 8 9 parse xml and store observations 10 figure 3: complexities of connecting multiple systems across domains, firewalls and security policies the last mile: using fax machines to exchange data between clinicians and public health 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 discussion the potential benefits of linking public health functions to clinical practice seem obvious. the link between newborn screening programs and clinical follow-up is tenuous and highly variable from state to state, 26 and information systems offer a way to improve communication. likewise, immunization rates are well below those needed to establish herd immunity, 27 and immunization registries can have a significant effect, but only if there is adequate participation by clinicians in the community. the health information technology for economic and clinical health (hitech) act includes “meaningful use” criteria and incentives for the meaningful adoption of health information technology, including linking ehrs to immunization registries. 12 however, these incentives will have relatively less impact on pediatric care because they only apply to clinicians whose patient panels include minimal levels of medicare or medicaid enrollees. because many pediatricians won’t meet these levels, and the majority don’t have comprehensive emrs, the atad approach we are developing may be important for some time. the advantage of our approach is that the clinician can share data with the public health community with only a fax machine and a phone line. however, this approach pushes the technical complexity upstream to entities running the health information exchange and the health department. the complexity of supporting a paper interface in an otherwise electronic health information exchange is substantial. for example, although most faxes can be interpreted by the software without human intervention, personnel with the skills to review faxes and manually enter data are needed if all of the data are to be captured. software systems for generating tailored paper forms and recognizing and interpreting those forms when returned by fax are complex, expensive and prone to errors. moreover, our approach depends on the existence of the health information exchange and the results delivery system that can handle images such as our atads. even when this infrastructure is in place, our programs had to link myriad systems across domains. hit standards help this effort, but security policies to link the domains must also be addressed. however, we see this project’s effort as another illustration of what can be achieved when a functional health information exchange has been established. we believe this approach will bridge the last mile, at least until emrs are in widespread use. admittedly, the bridge is not ideal. communication is asynchronous because a paper must be completed and faxed for each step in the communication. for use cases in which the data exchange must be faster, synchronous communication such as a real-time ehr connection, a web interface, or even a phone call will be necessary. in the future, the approach we have taken can be adapted to the delivery of electronic data directly to and from an ehr. in that case, the errors inherent in scanning paper, the additional manual effort to check the scans, and the need for fax machines will be eliminated. however, for a busy clinician without a linked ehr, logging into a web interface or making a phone call represents a diversion from the clinic workflow. only a medium that fits into busy clinic workflow will be acceptable. this is why a tailored, faxable, machine interpretable paper interface (i.e., an atad) offers a viable option. the last mile: using fax machines to exchange data between clinicians and public health 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 acknowledgements this work was funded by grant number 1p01hk000077 from the centers for disease control and prevention. corresponding author stephen m. downs, md, ms 460 west 10 th street, hs1000 indianapolis, in 46202 office: 317-278-0552 fax: 317-278-0456 e-mail: stmdowns@iupui.edu) references 1. thacker sb, berkelman rl. 1988. public health surveillance in the united states. epidemiol rev. 10, 164-90. 2. elson rb, connelly dp. 1995. computerized patient records in primary care: their role in mediating guidelinedriven physician behavior change. arch fam med. 4, 698-705. http://dx.doi.org/10.1001/archfami.4.8.698 3. yasnoff w, o’carroll p, koo d, linkins r, kilbourne e. 2000. public health informatics: improving and transforming public health in the information age. j public health manag pract. 6(6), 67-75. http://dx.doi.org/10.1097/00124784-200006060-00010 4. hinman a, atkinson d, diehn t, et al. principles and core functions of integrated child health information systems journal of public health management and practice. 2004 10 s52s56. 5. carroll ae, downs sm. 2006. comprehensive cost-utility analysis of newborn screening strategies. pediatrics. 117(5 pt 2), s287-95. 6. kemper ar, uren rl, moseley kl, clark sj. 2006. primary care physicians' attitudes regarding follow-up care for children with positive newborn screening results. pediatrics. 118(5), 1836-41. http://dx.doi.org/10.1542/peds.2006-1639 7. u.s. department of health and human services. 2000. office of disease prevention and health promotion--healthy people 2010. nasnewsletter. 15(3), 3. 8. zimmerman r. aafp, aap and acip release 1998 recommended childhood immunization schedule. 1998 9. progress in immunization information systems --united states, 2009. mmwr morb mortal wkly rep. jan 14;60(1):10-12. 10. leu mg, o'connor k, marshall r, klein jd. pediatricians' use of health information technology: a national survey. paper presented at: pediatric academic societies annual meeting2010. 11. kemper ar, uren rl, clark sj. 2006. adoption of electronic health records in primary care pediatric practices. pediatrics. 118(1), e20-24. http://dx.doi.org/10.1542/peds.2005-3000 mailto:stmdowns@iupui.edu the last mile: using fax machines to exchange data between clinicians and public health 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 12. health information technology: initial set of standards, implementation specifications, and certification criteria for electronic health record technology. final rule. fed regist. jul 28;75(144):44589-44654. 13. biondich pg, grannis sj. 2004. the indiana network for patient care: an integrated clinical information system informed by over thirty years of experience. j public health manag pract. suppl, s81-86. http://dx.doi.org/10.1097/00124784-200411001-00013 14.2010 annual report: indiana health information exchange;2011. 15. barnes m. 2007. lessons learned from the implementation of clinical messaging systems. amia annu symp proc. •••, 36-40. 16. anand v, biondich p, liu g, rosenman m. sm d. child health improvement through computer automation: the chica system. paper presented at: medinfo 20042004 san francisco. 17. seebregts cj, mamlin bw, biondich pg, et al. 2009. the openmrs implementers network. int j med inform. 78(11), 711-20. http://dx.doi.org/10.1016/j.ijmedinf.2008.09.005 18. wolfe ba, mamlin bw, biondich pg, et al. 2006. the openmrs system: collaborating toward an open source emr for developing countries. amia annu symp proc. •••, 1146. 19. jenders ra, hripcsak g, sideli rv, et al. 1995. medical decision support: experience with implementing the arden syntax at the columbia-presbyterian medical center. proc annu symp comput appl med care. •••, 169-73. 20. watson ms, mann my, lloyd-puryear ma, rinaldo p, howell rr. 2006. american college of medical genetics newborn screening expert group newborn screening: toward a uniform screening panel and system-executive summary. pediatrics. 117(5), s296-307. 21. zhu vj, overhage mj, egg j, downs sm, grannis sj. 2009. an empiric modification to the probabilistic record linkage algorithm using frequency-based weight scaling. j am med inform assoc. 16(5), 738-45. http://dx.doi.org/10.1197/jamia.m3186 22. davidson k. adapting vendor clinical systems for real-time registry participation using hl7. national immunization registry conference. vol atlanta, ga2003. 23.downs sm, van dyck pc, rinaldo p, et al. improving newborn screening laboratory test ordering and result reporting using health information exchange. j am med inform assoc. janfeb;17(1):13-18. 24. newborn screening ahic detailed use casewashington. dc: u.s. department of health and human services office of the national coordinator for health information technology; 2008 25. spivak l, dalzell l, berg a, et al. 2000. new york state universal newborn hearing screening demonstration project: inpatient outcome measures. ear hear. 21(2), 92-103. http:// dx.doi.org/10.1097/00003446-200004000-00004 26. kim s, lloyd-puryear ma, tonniges tf. 2003. examination of the communication practices between state newborn screening programs and the medical home. pediatrics. 111(2), e120-26. http://dx.doi.org/10.1542/peds.111.2.e120 27. centers for disease control and prevention, national immunization survey. 2011; http:// www.cdc.gov/nchs/nis/data_files.htm. accessed august 14, 2011. http://www.cdc.gov/nchs/nis/data_files.htm layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts syndromic surveillance from a local perspective – a review of the literature don olson*, kevin konty, rob mathes and marc paladini new york city department of health and mental hygiene, long island city, ny, usa objective review of the origins and evolution of the field of syndromic surveillance. compare the goals and objectives of public health surveillance and syndromic surveillance in particular. assess the science and practice of syndromic surveillance in the context of public health and national security priorities. evaluate syndromic surveillance in practice, using case studies from the perspective of a local public health department. introduction public health disease surveillance is defined as the ongoing systematic collection, analysis and interpretation of health data for use in the planning, implementation and evaluation of public health, with the overarching goal of providing information to government and the public to improve public health actions and guidance [1,2]. since the 1950s, the goals and objectives of disease surveillance have remained consistent [1]. however, the systems and processes have changed dramatically due to advances in information and communication technology, and the availability of electronic health data [2,3]. at the intersection of public health, national security and health information technology emerged the practice of syndromic surveillance [3]. methods to better understand the current state of the field, a review of the literature on syndromic surveillance was conducted: topics and keywords searched through pubmed and google scholar included biosurveillance, bioterrorism detection, computerized surveillance, electronic disease surveillance, situational awareness and syndromic surveillance, covering the areas of practice, research, preparedness and policy. this literature was compared with literature on traditional epidemiologic and public health surveillance. definitions, objectives, methods and evaluation findings presented in the literature were assessed with a focus on their relevance from a local perspective, particularly as related to syndromic surveillance systems and methods used by the new york city department of health and mental hygiene in the areas of development, implementation, evaluation, public health practice and epidemiological research. results a decade ago, the objective of syndromic surveillance was focused on outbreak and bioterrorism early-event detection (eed). while there have been clear recommendations for evaluation of syndromic surveillance systems and methods, the original detection paradigm for syndromic surveillance has not been adequately evaluated in practice, nor tested by real world events (ie, the systems have largely not ‘detected’ events of public health concern). in the absence of rigorous evaluation, the rationale and objectives for syndromic surveillance have broadened from outbreak and bioterrorism eed, to include all causes and hazards, and to encompass all data and analyses needed to achieve “situational awareness”, not simply detection. to evaluate current practices and provide meaningful guidance for local syndromic surveillance efforts, it is important to understand the emergence of the field in the broader context of public health disease surveillance. and it is important to recognize how the original stated objectives of eed have shifted in relation to actual evaluation, recommendation, standardization and implementation of syndromic systems at the local level. conclusions since 2001, the field of syndromic surveillance has rapidly expanded, following the dual requirements of national security and public health practice. the original objective of early outbreak or bioterrorism event detection remains a core objective of syndromic surveillance, and systems need to be rigorously evaluated through comparison of consistent methods and metrics, and public health outcomes. the broadened mandate for all-cause situation awareness needs to be focused into measureable public health surveillance outcomes and objectives that are consistent with established public health surveillance objectives and relevant to the local practice of public health [2]. keywords evaluation; biosurveillance; situational awareness; syndromic surveillance; local public health acknowledgments this work was carried out in conjunction with a grant from the alfred p. sloan foundation (#2010-12-14). we thank the members of the new york city department of health and mental hygiene syndromic surveillance unit. references 1. langmuir ad. evolution of the concept of surveillance in the united states. proc roy soc med. 1971;64:681-4. 2. smith pf, hadler jl, stanbury m, rolfs rt, hopkins rs; cste surveillance strategy group. “blueprint version 2.0”: updating public health surveillance for the 21st century. j public health manag pract. 2012; july 2 [epub ahead of print]. 3. mostashari f, hartman j. syndromic surveillance: a local perspective. j urban health 2003;80(2 suppl 1):i1-7. *don olson e-mail: drolson@gmail.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e82, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts tracking drug overdose trends in ohio using ed chief complaints alise l. brown*, william e. storm and brian e. fowler ohio department of health, columbus, oh, usa objective preliminary analysis was completed to define, identify, and track the trends of drug overdoses (od), both intentional and unintentional, from emergency department (ed) and urgent care (uc) chief complaint data. introduction the state of ohio, as well as the country, has experienced an increasing incidence of drug ods over the last three decades [3]. of the increased number of unintended drug od deaths in 2008, 9 out of 10 were caused by medications or illicit drugs [1]. in ohio, drug ods surpassed mvcs as the leading cause of injury death in 2007. this trend has continued through the most current available data [3]. using chief complaint data to quickly track changes in the geographical distribution, demographics, and volume of drug ods may aid public health efforts to decrease the number of associated deaths. methods chief complaint data from ed/uc visits were collected and analyzed from ohio’s syndromic surveillance application for 2010-2012. ninety-six percent of all ohio ed visits were captured during this timeframe. due to the nonspecific nature of chief complaints as well as the lack of detail given upon registration at the ed/uc, attempting to separate visits into intentional vs. unintentional was not feasible. therefore, a fairly specific classifier was created to define all potential ed/uc visits related to drug ods. the data were analyzed, using sas v 9.3, via time series analyses, and stratified by age, gender, and geographic region. although these data types are pre-diagnostic in nature, they are more readily accessible than discharge data. results on average, ohio observed approx 66 ed/uc visits per day related to drug ods from 2010-2012. the data show an increasing trend from 2010 through 2012 as well as a slight seasonal trend with higher visits observed in the spring/summer months as opposed to the autumn/winter months (figure 1). the data showed that females attributed to a higher frequency of the drug ods than males by approximately 4 ed/uc visits per day. other data sources show a higher incidence in males than females related to unintentional drug ods [3]. the highest age category attributing to the increase was the 18-39 years of age for both males and females, as shown in figure 2. population rates were calculated to identify those counties most affected by drug ods. the data showed the highest rates of ed/uc visits related to drug ods to be found in mostly rural areas of ohio. conclusions the annual death rate from unintentional drug poisonings by ohio residents has increased from 3.6 in 2000 to 13.4 per 100,000 population in 2010[3]. as a result, the ohio governor created a drug abuse task force in 2009[4]. ohio legislation (hb 93) implemented a prohibition on the operation of pain management clinics without a license on june 19, 2011[3]. according to this preliminary analysis, ed/uc visits related to drug ods 1 year post-implementation of hb 93 continue to increase. it is unclear if hb 93 has slowed the rate of increase. additionally, pre-diagnostic data has significant limitations including the significant possibility of misclassifying non-od patient encounters as ods. further study of post-diagnostic data to confirm these trends is warranted. keywords drug overdose; chief complaints; prescription drug abuse references 1. bm kuehn. poisonings top crashes for injury-related deaths: jama. 2012;307(3):242-242. doi:10.1001/jama.2011.1998. 2. ohio department of health. (july, 2012). ohio’s opioid epidemic: an overview of the problem. http://www.odh.ohio.gov/sitecore/content/healthyohio/default/vipp/data/rxdata.aspx 3. ohio injury prevention partnership, prescription drug abuse action group. hb 93 summary. http://www.ccbh.net/storage/prescriptionmeds/hb93summary.pdf 4. ohio prescription drug abuse task force. final report. http://www.odh.ohio.gov/~/media/odh/assets/files/web%20team /features/drug%20overdose/opdatffinalreport.ashx *alise l. brown e-mail: alise.brown@odh.ohio.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e121, 2013 isds annual conference proceedings 2017. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2016 conference abstracts seroprevalence of zoonotic diseases among farm animals in kvemo kartli (georgia) k goginashvili*1, m donduashvili1, gaga osiashvili1, ryan arner2 and lile malania3 1laboratory of the ministry of agriculture, tbilisi, georgia; 2metabiota inc, san fransisco, ca, usa; 3national center for disease control and public health, tbilisi, georgia objective the purpose of this research was to study the seroprevalence of zoonotic diseases among farm animals in the kvemo kartli region of georgia. introduction zoonotic diseases are an important cause of human morbidity and mortality; around 75% of recently emerging human infectious diseases are zoonoses. herein we report the first seroprevalence study to include a range of emerging or re-emerging zoonotic pathogens of economic concern (including: bacillus anthracis, coxiella burnetii, francisella spp., brucella spp., and crimean-congo hemorrhagic fever virus (cchfv)) affecting domestic animals (e.g., cattle, sheep, goat, and dog) in georgia. methods cattle (n=177) from gardabani, marneuli, and tsalka (kvemo kartli region) were sampled for the study as were small ruminants and dogs (n=30). bacillus anthracis, brucella spp., cchfv, and c. burnetii (phase i) were detected using elisa methods. francisella tularensis was detected using a microscopic agglutination test (mat). results of the cattle sampled, 11 were positive for f. tularensis, 39 were positive for brucella spp., and seven were positive for c. burnetii. all samples were negative for cchfv. three goat samples were positive for c. burnetii, one goat sample and one dog sample were positive for f. tularensis. conclusions domestic animals serve as a source of disease that can spread to humans through vectors or direct contact. in georgia, domestic animals were not previously studied for exposure to zoonotic diseases, with the exception of cattle, which were surveyed for brucellosis. in particular, the finding of f. tularensis seropositive animals is novel in georgia, as this region was considered free of the pathogen. screening studies of domestic/farm animals for zoonotic pathogens such as this can serve as a source of baseline data for regional risk assessments and to better inform one health measures. keywords emerging diseases; re-emerging diseases; zoonotic diseases; crimean-congo hemorrhagic fever acknowledgments the research study described in this presentation was made possible by financial support provided by the us defense threat reduction agency. the findings, opinions and views expressed herein belong to the authors and do not reflect an official position of the department of the army, department of defense, or the us government, or any other organization listed *k goginashvili e-mail: goginashvili@lma.ge online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 9(1):e159, 2017 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts sharing public health information with non-public health partners wayne loschen*, rekha holtry, kalman hazins and sheryl happel lewis johns hopkins university applied physics laboratory, laurel, md, usa objective the objective of this project is to provide a technical mechanism for information to be easily and securely shared between public health essence users and non-public health partners; specifically, emergency management, law enforcement, and the first responder community. this capability allows public health officials to analyze incoming data and create interpreted information to be shared with others. these interpretations are stored securely and can be viewed by approved users and captured by authorized software systems. this project provides tools that can enhance emergency management situational awareness of public health events. it also allows external partners a mechanism for providing feedback to support public health investigations. introduction automated electronic disease surveillance has become a common tool for most public health practitioners. users of these systems can analyze and visualize data coming from hospitals, schools, and a variety of sources to determine the health of their communities. the insights that users gain from these systems would be valuable information for emergency managers, law enforcement, and other nonpublic health officials. disseminating this information, however, can be difficult due to lack of secure tools and guidance policies. this abstract describes the development of tools necessary to support information sharing between public health and partner organizations. methods the project initially brought together public health and emergency management officials to determine current gaps in technology and policy that prevent sharing of information on a consistent basis. officials from across the national capital region (ncr) in maryland, virginia, and the district of columbia determined that a web portal in which public health information could be securely posted on and captured by non-public health users (humans and computer systems) would be best. the development team then found open source tools, such as the pebble blogging system, that would allow information to be posted, tagged, and searched in an easily navigable site. the system also provided rss feeds both on the site as whole and specific tags to support notification. the team made modifications to the system to incorporate spring security features to allow the site to be securely hosted requiring usernames and passwords for access. once the pebble system was completed and deployed, the ncr’s aggregated essence system was adapted to allow users to submit daily reports and post time series images to the new site. an additional feature was created to post visualizations every evening to the site summarizing the day’s reports. results the system has been in testing since march of 2012 and users of the system have provided valuable feedback. based on the success of the tests, public health users in the ncr have begun working on the policy component of the project to determine when and how it should be used. modifications to the system since deployment have included a single sign on capability for essence users and the desire to allow other features of essence to be posted beyond time series graphs, such as gis maps and statistical reports. conclusions having tools that can promote exchange of information between public health and non-public health partners such as emergency management, law enforcement, and first responders can greatly enhance the situational awareness and impact overall preparedness and response. by having tools embedded in essence, users are able to integrate the information sharing aspects into their daily routines with a small amount of effort. with the use of open source tools, the same type of capability can be easily replicated in other jurisdictions. this presentation will describe the lessons learned and potential improvements the project will incorporate in the future. keywords open source; emergency management; information sharing *wayne loschen e-mail: wayne.loschen@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e47, 2013 a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 1 ojphi a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states greg arling1, matthew blaser2, michael d. cailas3*, john r. canar4, brian cooper4, joel flaxhatch3, peter j. geraci5, kristin m. osiecki6, and apostolis sambanis5 1 purdue university, school of nursing, college of health and human sciences 2 united states environmental protection agency, research associate under an inter-agency agreement with oak ridge institute for science and education 3 environmental and occupational health sciences, school of public health, university of illinois chicago 4 united states environmental protection agency region v; and health policy and administration, school of public health, university of illinois chicago 5 health policy and administration, school of public health, university of illinois chicago 6 university of minnesota, rochester, center for learning innovation abstract considering the potential for widespread adoption of social vulnerability indices (svi) to prioritize covid-19 vaccinations, there is a need to carefully assess them, particularly for correspondence with outcomes (such as loss of life) in the context of the covid-19 pandemic. the university of illinois at chicago school of public health public health gis team developed a methodology for assessing and deriving vulnerability indices based on the premise that these indices are, in the final analysis, classifiers. application of this methodology to several midwestern states with a commonly used svi indicates that by using only the svi rankings there is a risk of assigning a high priority to locations with the lowest mortality rates and low priority to locations with the highest mortality rates. based on the findings, we propose using a two-dimensional approach to rationalize the distribution of vaccinations. this approach has the potential to account for areas with high vulnerability characteristics as well as to incorporate the areas that were hard hit by the pandemic. *corresponding author: mihalis@uic.edu doi: 10.5210/ojphi.v13i1.11621 copyright ©2021 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged i n the copy and the copy is used for educational, not-for-profit purposes. introduction this research brief summarizes the findings of an in-progress study conducted by the sph-phgis research team, which aims to identify the limitations and potentials of svis for prioritizing mailto:mihalis@uic.edu a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 2 ojphi vaccination plans. due to this issue's urgency and importance, the cdc's social vulnerability index (cdc.svi) will be used as a case study. here we present preliminary findings, with more to be reported in the coming weeks. the objectives of our research are to: assess the performance of the cdc.svi in classifying counties according to their covid-19 mortality rates; and propose an alternative approach to prioritization that incorporates both social vulnerability and actual experience of losses, i.e., covid-19 mortality. our goal is to provide better information on a community's vulnerability to a pandemic, as well as to the impact of vaccinations or other mitigation efforts in reducing mortality from the pandemic. background in october 2020, the national academies of sciences, engineering, and medicine (nasem) released a consensus study recommending a four-phase framework for equitable covid-19 vaccine allocation [1]. in december 2020, the advisory committee on immunization practices (acip) recommended a detailed phased implementation plan for vaccination, starting with health care personnel and residents of long-term care facilities [2]. given the limited supply of vaccines, the acip recommends for the next phase, 1b, to vaccinate "persons aged ≥75 years and frontline essential workers." [2] both of these public health institutions raise the issue of promoting justice and mitigating health inequalities, especially for the particular racial and ethnic minority groups that were disproportionally affected by covid-19 [1,2]. on this issue the nasem study made specific recommendations that "vaccine access should be prioritized for geographic areas identified through cdc's social vulnerability index or another more specific index." [1] the cdc's social vulnerability index (cdc.svi) is one of the many indices in use aiming to "help local officials identify communities that may need support before, during, or after disasters." [3] this svi, which is constructed from census data at various scales of aggregation, seeks to classify the relative social vulnerability of a location to a hazard based on a combination of factors. the cdc.svi has a separate set of rankings for census tracts and counties according to 15 social attributes, including unemployment, minority status, and disability obtained from the american community survey. the cdc.svi further groups these attributes into four related themes: socioeconomic status; household composition & disability; minority status & language; and housing type & transportation. census tract or county rankings can be obtained by state or nationally based on the individual indicator rankings, either summed across all 15 indicators or within each of the four themes. although each of the indices (i.e., themes) attempts to represent the underlying construct of social vulnerability, tapsell et al. have pointed out that "there is still no consensus on a) the primary factors that influence social vulnerability, b) the methodology to assess social vulnerability, or c) an equation that incorporates quantitative estimates of social vulnerability into either overall vulnerability assessment or risk." [4] the supporting documents for the acip recommendations raise a few of the issues that are likely to be exacerbated with the use of svis (see acip's evidence table for covid-19 vaccines allocation in phases 1b and 1c of the vaccination program). a notable strength of the cdc.svi is the ease with which public health (ph) agencies can obtain the cdc.svi ranking of their location from the well-organized cdc portal [3]. from the perspective of planning and resource allocation, social vulnerability is presumed to be an indicator of a community's risk for covid-19, along with the need for additional resources to mount mitigation efforts against the pandemic. the popularity of this rank-based svi has spawned other a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 3 ojphi rank-based indicators taking the same approach but directly addressing the covid-19 pandemic. for example, the covid-19 community vulnerability index (ccvi) “incorporates the latest evidence on covid-19 risk factors, fine-tuned with data collected over the course of the pandemic." [5] considering the potential for widespread adoption of svis to prioritize covid-19 vaccinations, we feel that this approach should be carefully assessed, particularly for correspondence with outcomes (such as loss of life) in the context of the covid-19 pandemic. most applications of the rank-based cdc.svi have been to single events such as natural or environmental disasters [6]. the covid-19 pandemic, in contrast, involves a series of events characterized by waves and extended now over more than a year. for the midwest, we know that the two waves have different characteristics [7] that are likely to challenge the applicability of svis. although cases have been distributed across different age groups, loss of life has been concentrated among older adults and disproportionately in nursing homes and other long-term care settings [8]. the modeling of risk and social vulnerability must take these unique circumstances into account. our earlier work in cook county, illinois, revealed differences in spatial patterns of covid-19 deaths in private households compared to those in long-term care facilities [8]. neighborhood characteristics were predictive of household deaths but not deaths in long-term care facilities. also, vaccination rollouts have been rapid and comprehensive for residents of long-term care facilities [9]. although people of advanced age and those from racial and ethnic groups living in the community have been assigned high priority for vaccinations, these groups have had substantially lower vaccination rates than whites [10]. nearly all major national covid-19 reporting portals disclose the total number of covid-19 deaths, with some offering separate reports on deaths in long-term care facilities. yet, none of them report deaths occurring in households only (i.e., persons not in long-term care or other group settings). also, much of the modeling of covid-19 incidence and mortality has failed to distinguish between these residential settings [11]. a strength of our research is the separation of mortality figures for the two settings [7,8,11]. in this analysis we examine deaths among individuals in private households, under the assumption that this is where the challenge of vaccine prioritization lies. assessment methodology the university of illinois at chicago school of public health public health gis (uic-sphphgis) team developed a methodology for assessing and deriving vulnerability indices based on the premise that these indices are, in the final analysis, classifiers. within this context, a svi represents categories of a societal state (i.e., defined by socioeconomic and environmental factors) that unrealized events such as a pandemic have the potential to harm and thereby cause losses. in essence, the index derivation approach (e.g., the ranking of the original variables and the additive model for the themes in the cdc.svi) becomes a classifier for each one of the n locations in terms of a potential for loss. the potential for loss is a common construct for many social vulnerability definitions, for example, "social vulnerability to natural hazards is the potential for loss and is complex interaction among risk, mitigation, and the social fabric of a place." [12] to validate the index as a classifier, a realized disaster loss (dl) event must be used corresponding to an actual disaster loss for each one of the n locations (e.g., number of deaths for a census tract or county). consequently, performance assessment of the svi classifier is easily accomplished by comparing the svi (i.e., potential for loss) and the dl severity (i.e., actual losses or harm) rankings of each a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 4 ojphi location. to simplify the assessment, a confusion or error matrix is used with m classes for each dimension; m << n and usually contains 3 to 5 classes to correspond to the common color visualization schemes seen in the plethora of svi maps. these classes are derived with the application of a binning or discretization methodology which transforms the n numerical values of a variable into m categorical counterparts. for our study, the m×m phgis performance assessment (pa) matrix has the structure in figure 1. figure 1. schematic of the performance assessment (pa) matrix proposed by the phgis team for evaluating the svis. the rank-based cdc.svi as a prioritization tool for covid-19 vaccination programs needs to identify high-risk areas, which are likely to be those with the greatest losses. the implicit assumption is that socioeconomic and environmental conditions, as well as the health condition of the residents, are the underlying causes of this elevated risk that leads to losses. this is aptly expressed in a rank-based ccvi report focusing on loss data that "can help us understand where and how the disease is impacting vulnerable populations, in order to prioritize resources and rapid response accordingly." [5] the matching areas in terms of the two classifiers are contained in the diagonal elements of the phgis pa matrix, cii, providing an overall classification performance measure (figure 1). for example, the first element of the pa matrix, c11, contains the areas (e.g., counties) classified as having the lowest vulnerability and realization of losses. the sum of the matching areas divided by the total number of areas, n, yields an overall classification performance (ocp) rate. similarly, the off-diagonal elements, cij, of the pa matrix identify the misclassified areas. these are areas recording a discrepancy between the class of their vulnerability status and the severity of the losses from past or on-going events. for example, the last element of the 1st column, cm1, indicates the number of areas with the highest actual disaster loss that were classified to be the lowest vulnerable areas by the svi. the sum of these below off-diagonal elements divided by the total number of areas, n, yields an overall underestimation rate (our). on the other hand, the element on the top right-hand corner indicates the areas that were predicted to have the highest vulnerability but a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 5 ojphi experienced the lowest level of dl. the elements above the diagonal indicate overestimation error (oe). the sum of these upper off-diagonal elements divided by the total number of areas, n, yields an overall overestimation rate (oer). ideally, a well-designed covid-19 vaccination plan will have a minimum of both our and oer. a high our implies high-risk areas that are not accounted for by the svi, whereas a high oer implies allocation of valuable vaccine resources in areas with low risk. case studies the study areas for our assessment of the cdc.svi are counties in illinois(n=102) and wisconsin (n=72). the index rankings for all of the counties were derived from the cdc.svi portal. we focus on the second covid-19 wave, because of its recency and because it has different patterns from the first wave. illinois and wisconsin were selected due to their differences in spatial mortality patterns between waves. the assessment variable (target) was the household mortality rate (per 100,000). details about the wave dates and characteristics are provided by the authors at the midwest comprehensive visualization dashboards: covid-19 mcvd [13]. the vulnerability status to the pandemic is accounted for with the use of the summary classification (i.e., sum of the four cdc.svi themes). the realization of the pandemic is represented by the dl (i.e., covid-19 related deaths as of january 17, 2021). for this study, dl is the mortality rate per 100,000 of the household (not nursing home or long-term care) population recorded in the counties during the second wave of the pandemic [11]. for this application four classes of severity were used (1 is the lowest, 4 the most severe). findings for counties in illinois and wisconsin are reported separately for the sum of the ranks across all four themes and for theme 3, minority status and language (figures 2 to 5). if vaccine prioritization were to be based solely on vulnerability according to the cdc.svi, it would channel vaccinations and other resources first into svi category 4, followed by svi category 3, svi 2, svi 1. unfortunately, the cdc.svi categories for the counties do not match well with covid-19 mortality rates. the mismatch patterns are consistent across all four pa matrices. a good match between vulnerability status and dl severity, by county, is seen in the diagonal elements of the pa matrix. counties in the lower left cells would have high dl combined with low vulnerability. this mismatch could be of special ph concern in the cells furthest from the diagonal (i.e., close to c41), as they would have the lowest priority for vaccination even though they were in the top quartile for dl severity. conversely, counties in the upper right cells have low dl combined with a high vulnerability index. the cells furthest from the diagonal (i.e., close to c14) would be given high priority for vaccination despite being in the bottom quartiles for dls. a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 6 ojphi figures 2 and 3. illinois counties phgis performance assessment (pa) matrix with four categories applied for the summary cdc.svi and the theme 3 ranking of counties and their mortality rates. figures 4 and 5. wisconsin counties phgis pa matrix with four categories applied for the summary cdc.svi and the theme 3 ranking of counties and their mortality rates from a statistical perspective, the measures of (mis)classification, or match/mismatch between vaccine prioritization (vulnerability index) and covid-19 mortality rate in the counties were consistent across the four matrices, two for each state. the overall classification performance (ocp) was relatively low (ranging from 25.0% to 31.4%), while the overestimation rate (oer) and underestimation rates (uer) were in the same consistently high range (33.3% to 38.2%). when we constructed similar matrices for three other midwestern states (figure 6), we found generally a lower matching classification (i.e., ocp) and higher overand underestimation rates a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 7 ojphi (oer and uer). for example, the ocps ranged from 14.9% to 28.3%, the uers ranged from 31.5% to 41.0%, and the oers ranged from 35.6% to 44.8%. figure 6. classification performance (ocp) and over and under estimation rates (uer and oer) for the cdv.svi ranking of counties in three midwestern states by dl categories use of the phgis pa matrix as a tool for setting and monitoring vaccine priorities our assessment suggests that the cdc.svi may not be tapping into key factors contributing to losses from the covid-19 pandemic. therefore, this tool will need to be augmented to improve its value in planning for an initial vaccination rollout and for monitoring the effectiveness of vaccinations as they are deployed in a community. an effective prioritization tool will need to predict initial vulnerability to a loss as well as being able to track a community's success in mitigating against risk through vaccinations or other interventions. the phgis pa matrix, which we applied in assessing the performance of the cdc.svi, could also serve as a prioritization tool. the phgis-pa approach overcomes the one-dimensional aspect of svis. it takes into account (albeit incompletely) factors contributing to vulnerability, as well as a community's actual experience of losses. • the matrix could be applied for vaccination planning and priority setting by determining which counties fit into each of the cells based on their combinations of svi vulnerability and realized losses, i.e., from the beginning of the current wave up to the time of initial vaccination priority setting. • in addition, the matrix could be used for tracking the effects of vaccinations by updating the loss categories periodically, i.e., updated weekly based on a four-week rolling average. by tracking transitions from one loss category to another, it would be possible to assess vaccination roll-out effectiveness over time. • the matrix structure could be expanded to include additional dimensions, such as rates of vaccinations and priority populations, in order to obtain a clearer picture of effectiveness. as an example of how the matrix could be employed for priority settings, we use the cdc.svi, in lieu of a more-refined svi that we have under development. we refer again to figures 2 to 5. the a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 8 ojphi ordering of initial priorities would be straightforward for counties in cells along the diagonal, where vulnerability and losses line up well. the difficult cases are the counties in cells off the diagonal. counties in the lower left cells would have high dl combined with a low vulnerability index. this mismatch could be of special concern in the cells furthest from the diagonal (i.e., close to c41) because they would have a lower priority for vaccination if vulnerability were the main criterion. yet, they were the counties with the worst losses. the vulnerability of these counties – as well as any factors that would suggest high losses continuing into the future, absent of mitigation efforts – need to be further investigated. conversely, counties in the upper right cells would have low dl yet a high vulnerability index. the cells furthest from the diagonal (i.e., close to c14) would be given high priority for vaccines from the standpoint of vulnerability, despite being in the bottom quartiles for dls. again, further investigation would be advised to determine if the counties should remain a high priority (because, for example, of the potential for increased losses). application of the phgis-pa matrix approach for tracking and continuous priority setting would involve an updating of the matrix as new data arrived about losses, and perhaps vaccine rollouts. the focus would be on changes in a county's cell membership between periods, which could indicate the need for re-ordering of priorities to counties experiencing increases in losses despite mitigation efforts. conclusions given the vaccine limitations and the need to ration the doses, the use of a social vulnerability index such as cdc's svi alone as a planning tool for prioritizing vaccinations will not suffice to satisfy the multifaceted mitigation needs of a rational vaccination strategy. assessment of this index with the phgis pa matrix approach found that the cdc.svi risks assigning high priority to locations with the lowest mortality rates, and low priority to locations with the highest mortality rates. the uic sph phgis team is proposing to use a two-dimensional approach for rationalizing the distribution of vaccinations. this approach has the potential to account for areas with high vulnerability characteristics as well as to incorporate the areas that were hard hit by covid-19. further research is under way to develop a planning tool with improved predictive performance that is trained on the covid-19 experience and that incorporates the social vulnerability factors that contribute most to a community's vulnerability to the covid-19 pandemic. these findings could be further explored at a state and county level with the use of the midwest comprehensive visualization dashboard (mcvd), designed specifically for visualizing the spatial distribution of vulnerability and mortality at a county level throughout the midwest. this dashboard is available at: https://univofillinois.maps.arcgis.com/apps/mapseries/index.html?appid=8bd3f5653abb41619b5 0d8c974e8a72b references 1. national academies of sciences, engineering, and medicine. 2020. framework for equitable allocation of covid-19 vaccine. washington, dc: the national academies press. https://doi.org/10.17226/25917. https://univofillinois.maps.arcgis.com/apps/mapseries/index.html?appid=8bd3f5653abb41619b50d8c974e8a72b https://univofillinois.maps.arcgis.com/apps/mapseries/index.html?appid=8bd3f5653abb41619b50d8c974e8a72b a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 9 ojphi 2. dooling, k, marin, m., wallace, m., et al. the advisory committee on immunization practices’ updated interim recommendation for allocation of covid-19 vaccine — united states, december 2020. mmwr morb mortal wkly report 2021; 69:1657-1660. doi: http://dx.doi.org/10.15585/mmwr.mm695152e2external icon. 3. social vulnerability index cdc. centers for disease control and prevention, geospatial research analysis, and services program (grasp), division of toxicology and human health sciences. available at: https://www.atsdr.cdc.gov/placeandhealth/svi/index.html. accessed february 15, 2021. 4. tapsell s, mccarthy s, faulkner h, alexander m. (2010). social vulnerability and natural hazards. caphaz-net wp4 report, flood hazard research centre – fhrc, middlesex university, london available at: http://caphaz-net.org/outcomes-results/caphaznet_wp4_social-vulnerability.pdf. accessed may 21, 2018. 5. surgo ventures. vulnerable communities and covid-19: the damage done, and the way forward. version 1, published january 27, 2021. available at: https://precisionforcovid.org/ccvi. accessed february 10, 2021. 6. flanagan be, gregory ew, hallisey ej, heitgerd jl, lewis b. 2011. a social vulnerability index for disaster management. j homel secur emerg manage. 8(1), 3. doi:https://doi.org/10.2202/1547-7355.1792. 7. arling gw, blaser m, cailas md, canar j, cooper b, et al. 2020. a second wave of covid-19 in cook county: what lessons can be applied? online j public health inform. 12(2), e15. doi:https://doi.org/10.5210/ojphi.v12i2.11506. pubmed 8. blaser m, cailas md, canar j, cooper b, geraci p, et al. analyzing covid-19 mortality within the chicagoland area: data limitations and solutions. research brief no. 117. policy, practice and prevention research center, university of illinois chicago. chicago, il. july 2020. doi: https://doi.org/10.25417/uic.13470324.v19. cdc covid data tracker. federal pharmacy partnership for long-term care (ltc) program. centers for disease control and prevention. available at: https://covid.cdc.gov/covid-datatracker/#vaccinations-ltc. accessed february 18, 2021. 10. recht h, weber l. covid-19: as vaccine rollout expands, black americans still left behind. kaiser health news. january 29, 2021. available at: https://khn.org/news/article/asvaccine-rollout-expands-black-americans-still-left-behind. accessed february 18, 2021. 11. canar j, osiecki k, sambanis a, arling g, cooper b, et al. a comprehensive analytic framework for covid-19 mortality applicable to major metropolitan centers. bmc public health. (submitted to). 12. schimidlin tw, hammer bo, ono y, king ps. 2009. tornado shelter-seeking behavior and tornado shelter options among mobile home residents in the united states. nat hazards. 48, 191-201. https://doi.org/10.1007/s11069-008-9257-z https://doi.org/10.2202/1547-7355.1792 https://doi.org/10.5210/ojphi.v12i2.11506 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=33381281&dopt=abstract https://doi.org/10.1007/s11069-008-9257-z a data driven approach for prioritizing covid-19 vaccinations in the midwestern united states online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e5, 2021 10 ojphi 13. blaser, m, canar, j., arling, g., cailas, m. (2021): midwest comprehensive visualization dashboards: covid-19 mcvd. university of illinois at chicago. phgis program report. phgis-wp-2.2020.12.28. https://doi.org/10.25417/uic.13650440.v1 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a biosurveillance-driven home score to guide strep pharyngitis treatment andrew fine*1, 2, victor nizet3 and kenneth mandl1, 2 1boston children’s hospital, boston, ma, usa; 2harvard medical school, boston, ma, usa; 3ucsd, la jolla, ca, usa objective 1. to derive and validate an accurate clinical prediction model (“home score”) to estimate a patient’s risk of group a streptococcal (gas) pharyngitis before a health care visit based only on history and real-time local biosurveillance, and to compare its accuracy to traditional clinical prediction models composed of history and physical exam features. 2. to examine the impact of a home score on patient and public health outcomes. introduction gas pharyngitis affects hundreds of millions of individuals globally each year, and over 12 million seek care in the united states annually for sore throat. clinicians cannot differentiate gas from other causes of acute pharyngitis based on the oropharynx exam, so consensus guidelines recommend use of clinical scores to classify gas risk and guide management of adults with acute pharyngitis. when the clinical score is low, consensus guidelines agree patients should neither be tested nor treated for gas. a prediction model that could identify very-low risk patients prior to an ambulatory visit could reduce low-yield, unnecessary visits for a most common outpatient condition. we recently showed that real-time biosurveillance can further identify patients at low-risk of gas. with increasing emphasis on patient-centric health care and the well-documented barriers impeding clinicians’ incorporation of prediction models into medical practice, this presents an opportunity to create a patient-centric model for gas pharyngitis based on history and recent local epidemiology. we refer to this model as the “home score,” because it is designed for use prior to a physical exam. methods analysis of data collected from 110,208 patients 3 years and older who presented with pharyngitis to a national retail health chain, from 2006-08. practitioners collected standardized historical and physical exam information based on algorithm-driven care, and all patients with pharyngitis were tested for gas. we used a previously validated biosurveillance variable reflecting disease incidence called recent local proportion positive (rlpp), which represents the proportion of patients who tested gas positive in a local market in the previous 14 days. to derive the “home score,” candidate variables were restricted to demographic factors, historical items and the rlpp, while physical exam variables (such as exudate), were excluded. multivariate analytic techniques were used to identify predictors of gas. for each home score (0-100), we calculated the percent of patients who tested positive, and we examined the relationship between the home score and gas positivity. standard metrics (sensitivity, specificity, positive and negative predictive value, and auc) were used to compare the performance of the home score to standard scores. we computed the number of patients aged >= 15 years who, according to the home score, were at low risk for gas, and therefore might avoid or delay a trip to a medical provider. outcomes included the numbers of reduced visits and the number of additional missed gas cases compared to the standard centor score approach (do not test/do not treat if centor score is 0-1). to facilitate comparison across different risk thresholds, we calculated outcomes for hypothetical cohorts of 1000 patients, and extrapolated these findings to provide the impact on 12 million annual national pharyngitis visits. results the 3 best predictors were fever (or 2.43, 95%ci 2.33-2.54), absence of cough (1.71,1.63-1.80) and rlpp (1.04,1.04-1.04 per unit change in rlpp). using a home score cutoff of 0.10 to identify adults at low risk would save 230,000 ambulatory visits annually while missing only 8500 additional gas cases. at a 0.20 cutoff, 2.9 million visits would be saved, and 320,000 more cases missed each year. there was a strong correlation between the percent testing positive and the home score (r-square=0.98). as the home score increases, there is a linear increase in the risk of gas (slope=1.02). the home score auc was 0.66, approaching the centor score (0.69) even without any physical exam information. conclusions a biosurveillance-driven home score to guide treatment of strep pharyngitis could save millions of visits annually by identifying patients in the pre-visit setting who would be unlikely to be tested or treated. keywords biosurveillance; pharyngitis; retail health *andrew fine e-mail: andrew.fine@childrens.harvard.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e23, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts refinement of a population-based bayesian network for fusion of health surveillance data howard burkom*, yevgeniy elbert, liane ramac-thomas, christopher cuellar and vivian hung johns hopkins applied physics laboratory, laurel, md, usa objective the project involves analytic combination of multiple evidence sources to monitor health at hundreds of care facilities. a demonstration module featuring a population-based bayes network [1] was refined and expanded for application in the department of defense electronic surveillance system for community-based epidemics (essence). introduction the essence demonstration module was built to help dod health monitors make routine decisions based on disparate evidence sources such as daily counts of ili-related chief complaints, ratios of positive lab tests for influenza, patient age distribution, and counts of antiviral prescriptions [1]. the module was a population-based (rather than individual-based) bayesian network (pbn) in that inputs were algorithmic results from these multiple aggregate data streams, and output was the degree of belief that the combined evidence required investigation. the module reduced total alerts substantially and retained sensitivity to the majority of documented outbreaks while clarifying underlying sources of evidence. the current effort was to advance the prototype to production by refining components of the fusion methodology to improve sensitivity while retaining the reduced alert rate. methods the multi-level approach to sensitivity improvement included expanded syndromic queries, more data-sensitive algorithm selection, improved transformation of algorithm outputs to alert states, and hierarchical training of bayesian networks. components were tested individually, and the net result was iteratively refined with performance using documented outbreaks. we examined time series of classes of prescribed drugs and laboratory tests during known events and discussed outbreak-associated elements with domain experts to liberalize data queries. algorithms were matched to data streams with injection testing applied to 4.5 years of data from 502 outpatient clinics. a hierarchical approach was applied for improved training and verification of pbns for events related to categories of influenza-like illness, gastrointestinal, fever, neurological, and rash, chosen both for public health importance and for availability of multiple supporting data types. hierarchical, modular training was applied to common subnetworks, such as a severity indicator pbn depending on case disposition, acute case indicators, complex evaluation/management codes, and patient bounce-backs, depicted in figure 1. conversion of individual algorithm outputs to belief states (e.g. “at least two red alerts/past 7 days”) was broadened using analysis of lags between data sources. with data from the known events, we calculated decision support thresholds for the parent-level pbn decision nodes with a stochastic optimization technique maximizing the ratio of alert rates during outbreak to non-outbreak periods. results the expanded data queries, more stream-specific algorithm selection, generalized state transformation, and hierarchical pbn training detected 22 of an expanded collection of 24 documented outbreaks, with incremental improvement ongoing. the mean alert rate drop achieved by the bayes net was 87% (minimum of 85%) compared to the combined alerts of all component algorithms across syndromes and facilities. conclusions expansion and further technical validation upheld the pbn approach as a user-friendly means of analytic decision support given multiple, variably weighted evidence sources. the pbn affords not only sharply reduced alerting, but also transparent indication of evidence underlying each alert. the older algorithm approach remains available as backup. beta testing of the resulting production system will drive further modification. figure 1: pbn subnetwork for event severity, based on outpatient data fields keywords fusion; bayesian network; multivariate; decision support acknowledgments drs. julie pavlin and rhonda lizewski of the armed forces health surveillance center for dataand event-related consultation and joe lombardo and wayne loschen of johns hopkins apl for consultation on production enhancement. references burkom h, elbert y, ramac-thomas l et al., analytic fusion of essence clinical evidence sources for routine decision support, emerging health threats journal supplements, eissn 1752-8550, issn 2001 1350 (print). *howard burkom e-mail: howard.burkom@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e6, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts sages update: electronic disease surveillance in resource-limited settings lewis l. sheri, timothy c. campbell, jacqueline s. coberly, richard a. wojcik, shraddha v. patel and brian feighner* johns hopkins university applied physics laboratory, laurel, md, usa objective the suite for automated global electronic biosurveillance (sages) is a collection of modular, flexible, open-source software tools for electronic disease surveillance in resource-limited settings. this demonstration will illustrate several new innovations and update attendees on new users in africa and asia. introduction the new 2005 international health regulations (ihr), a legally binding instrument for all 194 who member countries, significantly expanded the scope of reportable conditions and are intended to help prevent and respond to global public health threats. sages aims to improve local public health surveillance and ihr compliance with particular emphasis on resource-limited settings. more than a decade ago, in collaboration with the us department of defense (dod), the johns hopkins university applied physics laboratory (jhu/apl) developed the electronic surveillance system for the early notification of community-based epidemics (essence). essence collects, processes, and analyzes non-traditional data sources (i.e. chief complaints from hospital emergency departments, school absentee data, poison control center calls, over-the-counter pharmaceutical sales, etc.) to identify anomalous disease activity in a community. the data can be queried, analyzed, and visualized both temporally and spatially by the end user. the current sages initiative leverages the experience gained in the development of essence, and the analysis and visualization components of sages are built with the same features in mind. methods sages tools are organized into four categories: 1) data collection, 2) analysis & visualization, 3) communications, and 4) modeling / simulation / evaluation. within each category, sages offers a variety of tools compatible with surveillance needs and different types or levels of information technology infrastructure. sages tools are built in a modular nature, which allows for the user to select one or more tools to enhance an existing surveillance system or use the tools en masse for an end-to-end electronic disease surveillance capability. thus, each locality can select tools from sages based upon their needs, capabilities, and existing systems to create a customized electronic disease surveillance system. new openessence developments include improved data query ability, improved mapping functionality, and enhanced training materials. new cellular phone developments include the ability to concatenate single sms messages sent by simple or smart android cell phones. this ‘multiple-sms’ message ability allows use of sms technology to send and receive health information exceeding normal sms message length in a manner transparent to the users. conclusions the sages project is intended to enhance electronic disease surveillance capacity in resource-limited settings around the world. we have combined electronic disease surveillance tools developed at jhu/apl with other freely-available, interoperable software tools to create sages. we believe this suite of tools will facilitate local and regional electronic disease surveillance, regional public health collaborations, and international disease reporting. sages development, funded by the us armed forces health surveillance center, continues as we add new international collaborators. sages tools are currently deployed in locations in africa, asia and south america, and are offered to other interested countries around the world. keywords software; surveillance; electronic; open-source *brian feighner e-mail: brian.feighner@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e203, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts adapting syndromic surveillance systems to increase value to local health departments erika samoff*1, mary t. fangman1, amy ising2, lana deyneka3 and anna e. waller2 1ncperrc, university of north carolina, chapel hill, nc, usa; 2carolina center for health informatics, university of north carolina school of medicine, chapel hill, nc, usa; 3north carolina division of public health, chapel hill, nc, usa objective our objective was to describe changes in use following syndromic surveillance system modifications and assess the effectiveness of these modifications. introduction syndromic surveillance systems offer richer understanding of population health. however, because of their complexity, they are less used at small public health agencies, such as many local health departments (lhds). the evolution of these systems has included modifying user interfaces for more efficient and effective use at the local level. the north carolina preparedness and emergency response research center previously evaluated use of syndromic surveillance information at lhds in north carolina. since this time, both the nc detect system and distribution of syndromic surveillance information by the state public health agency have changed. this work describes use following these changes. methods data from nc detect were used to assess the number of users and usage time. staff from 14 nc lhds in 2009 and from 39 lhds in 2012 were surveyed (may-august of 2009 and june of 2012) to gather information on the mode of access to syndromic surveillance information and how this information was used. data were analyzed to assess the link between the mode of access and use of syndromic surveillance data. results system changes made between 2009 and 2012 included the creation of “dashboards” (figure 1) which present users with lhd-specific charts and graphs upon login and increases in the distribution of syndromic surveillance information by the state public health agency. the number of lhd-based nc detect system users increased from 99 in 2009 to 175 in 2012. sixty-two of 72 respondents completed the 2012 survey (86%). syndromic surveillance information was used in 28/40 lhds (70%) for key public health tasks. among 20 nc edss leads reporting an outbreak in the past year, 25% reported using data from nc detect for outbreak response, compared to 23% in 2009 (figure 2). among 30 responding nc edss leads, 57% reported using data from nc detect to respond to seasonal events such as heat-related illness or influenza, compared to 46% in 2009. nc detect data were reported to have been used for program management by 30% (compared to 25% in 2009), and to have been used in reports by 33% (compared to 23% in 2009). conclusions changes in how syndromic surveillance information was distributed supported modest increases in use in lhds. because use of syndromic surveillance data at smaller lhds is rare, these modest increases are important indicators of effective modification of the nc syndromic surveillance system. keywords evaluation; public health practice; syndromic surveillance; surveillance; local health department acknowledgments we thank aaron fleischauer, anne hakenewerth, and north carolina local health department staff members for their time and insights. this research was carried out by the north carolina preparedness and emergency response research center (ncperrc) which is part of the unc center for public health preparedness at the university of north carolina at chapel hill’s gillings school of global public health and was supported by the centers for disease control and prevention (cdc) grant 1po1 tp 000296. the contents are solely the responsibility of the authors and do not necessarily represent the official views of cdc. additional information can be found at http://cphp.sph.unc.edu/ncperrc/. *erika samoff e-mail: erika.samoff@unc.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e83, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts surveillance-based program planning rossi sanusi* center for health service management, gadjah mada university school of medicine, yogyakarta, indonesia objective to analyze the integrated behavioral & biological surveillance (ibbs) 2011 data for designing a condom utilization program. introduction the ibbs is part of the indonesian moh hiv surveillance system, which include serological surveillance, behavioral surveillance, reproductive tract infection survey, and monthly hiv/aids facilitybased (hospitals, hcs, vct sites) monthly reports. the ibbs 2011 was conducted in 11 provinces (22 districts/municipalities) encompassing eight most at risk populations (marps) – injection drug users, transsexuals, men who have sex with men, youths, inmates, mobile men, direct female sex workers (fsws), and indirect fsws. data of 442 direct fsws of the jayapura municipality and jayawijaya district (papua province) showed that 406 (91.85%) have sex with partners who did not use condoms. of these 406 fsws 60 (14.78%) were hiv positive and 231 (56.89%) were std positive. methods items of the direct fsw questionnaire, ibbs 2011, were examined and items that would yield information regarding content and method of hiv prevention interventions by means of condoms were identified. the stata12 software was used to inspect/codebook the variables related to the selected items, to recode numeric data into categorical data, to generate one-way and two-way tables, and to produce pairwise correlations (and their significance levels). results the direct fsws ibbs 2011 data of the jayapura municipality and jayawijaya district showed that there are significant positive correlations between condom use behavior variables of fsws (i.e., to know, to possess, to buy, and to offer male condoms) and variables of last-sex encounter condom use by customers, and between the latter and hiv and std lab results. the correlations were low, however, of the condom use behavior variables and variables that are related to comprehensive knowledge of hiv prevention, condom use by more steady sex partners (e.g., husbands, boyfriends, other males) and female condom utilization, and during last-week and last-month sex transactions. the data analyses also indicated details of the distribution of the fsws, with their condom use behaviors, according to individual characteristics, cie (communication, information & education) intervention utilization, condom acquirement, and sexual behavior. conclusions the condom utilization campaigns ought to focus on continuous reminders (instead of education programs) about how to persuade customers and other sex partners to use condoms, or to allow fsws to use female condoms, and about where to go for hiv/std testing and treatment. the condom promotion drives should use posters, tv ads, and field/health workers, the program should also make certain that good quality condoms be made avaible by local managers (of brothels, hotels, bars, etc.) and local vendors (drugists, stands, mobile carts). keywords ibbs; condom use; hiv; fsws; papua acknowledgments the author thanks the directorate general of disease control & environmental health, moh, republic of indonesia (for allowing to use the ibbs 2011 data) and family health indonesia (for funding the ibbs 2011 data analysis training program). references ghimire, l., smith, w., & van teijlingen, e.r. (2011). utilisation of sexual health services by female sex workers in nepal. bmc health services research 2011, 11:79. longfield, k., panyanouvong, x., chen, j., & kays, m.b.. (2011). increasing safer sexual behavior among lao kathoy through an integrated social marketing approach. bmc public health 2011, 11:872. moh, republic of indonesia. (2011). report on the development of hiv & aids in indonesia until june 2011. *rossi sanusi e-mail: rossi_sanusi@yahoo.com online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e175, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts advancing surveillance outside the usa: the canadian policy, practice, and research context effie gournis*1, 2 and david buckeridge3, 4 1toronto public health, toronto, on, canada; 2dalla lana school of public health university of toronto, toronto, on, canada; 3mcgill university, montreal, qc, canada; 4direction de sante publique de montreal, montreal, qc, canada objective 1) to explore how isds can better support researchers and public health practitioners working in the field of disease surveillance outside the united states; and 2) to identify current surveillance issues in the canadian public health system where isds can support dialogue and action. introduction the international society for disease surveillance has successfully brought together practitioners and researchers to share tools, ideas, and strategies to strengthen health surveillance systems. the society has evolved from an initial focus on syndromic surveillance to a broader consideration of innovation in health surveillance. more recently, isds has also worked to support surveillance research and practice in international resource-constrained settings. individuals who work in surveillance in developed countries outside the usa, however, have received little direct attention from isds. the policy and practice contexts in these countries are often quite different than the usa, so there is a need to support surveillance innovation in these countries in a manner that fits the context. canadian surveillance practitioners and researchers comprise the largest international group of isds members, and these members have expressed an interest in working with isds to translate surveillance innovations into practice in canada, where a national surveillance network and forum is lacking. this round table will consider how isds can help to support members in countries like canada and will identify next steps for promoting the science and practice of disease surveillance in the canadian context. methods individuals attending the isds 2012 conference with an interest in public health surveillance in canada or other similar countries outside the usa will be invited to discuss how isds can better support their activities. the discussion will be structured around questions and results received for a survey circulated to canadian isds members. the goal will be to discuss whether there is a specific formal role isds can play in helping members in canada and other similar countries working in public health surveillance. results discussion will be prompted through sharing results of a recent survey distributed to all canadian isds members and affiliates aimed at gauging their interest in developing a canadian focused group within isds, whether they believe there is a need, and how we might accomplish this. the survey questions, range of answers, and implications to future actions suggested in survey responses would drive the discussion. keywords international surveillance; canada; surveillance network *effie gournis e-mail: egourni@toronto.ca online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e193, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts enhanced influenza surveillance using telephone triage data in the va essence biosurveillance system cynthia a. lucero-obusan*1, carla a. winston1, patricia l. schirmer1, gina oda1, anoshiravan mostaghimi1 and mark holodniy1, 2 1department of veterans affairs, office of public health, washington, dc, usa; 2division of infectious diseases & geographic medicine, stanford university, stanford, ca, usa objective to evaluate the utility and timeliness of telephone triage (tt) for influenza surveillance in the department of veterans affairs (va). introduction telephone triage is a relatively new data source available to biosurveillance systems.1-2 because early detection and warning is a high priority, many biosurveillance systems have begun to collect and analyze data from non-traditional sources [absenteeism records, overthe-counter drug sales, electronic laboratory reporting, internet searches (e.g. google flu trends) and tt]. these sources may provide disease activity alerts earlier than conventional sources. little is known about whether va telephone program influenza data correlates with established influenza biosurveillance. methods veterans phoning va’s tt system, and those admitted or seen at a va facility with influenza or influenza-like-illness (ili) diagnosis were included in this analysis. influenza-specific icd-9-cm coded emergency department (ed) and urgent care (uc) visits, hospitalizations, tt calls, and ili outpatient visits were analyzed covering 2010-2011 and 2011-2012 influenza seasons (july 11, 2010-april 14, 2012). data came from 80 va medical centers and over 500 outpatient clinics with complete reporting data for the time period of interest. we calculated spearman rank-order coefficients, 95% confidence intervals and p-values using fisher’s z transformation to describe correlation between tt data and other influenza healthcare measures. for comparison of time trends, we plotted data for hospitalizations, ed/uc visits and outpatient ili syndrome visits against tt encounters. we applied essence detection algorithms to identify high-level alerts for influenza activity. essence aberration detection was restricted to the 2011-2012 season because limited historical tt and outpatient data from 2009-2010 was available to accurately predict aberrancy in the 2010-2011 season. we then calculated the peak measure of healthcare utilization during both influenza seasons (2010-2011 and 2011-2012) for each data source and compared timing of peaks and alerts between tt and other healthcare encounters to assess maximum healthcare system usage and timeliness of surveillance. results there were 7,044 influenza-coded calls, 564 hospitalizations, 1,849 emergency/urgent visits, and 416,613 ili-coded outpatient visits. spearman rank correlation coefficients were calculated for influenza-coded calls with hospitalizations (0.77); ed/uc visits (0.85); and ili-outpatient visits (0.88), respectively (p< 0.0001 for all correlations). peak influenza activity occurred on the same week or within 1 week across all settings for both seasons. for the 2011-2012 season, tt alerted with increased influenza activity before all other settings. conclusions data from va telephone care correlates well with other va data sources for influenza activity. tt may serve to augment these existing clinical data sources and provide earlier alerts of influenza activity. as a national health care system with a large patient population, va could provide a robust early-warning system for influenza if ongoing biosurveillance activities are combined with tt data. additional analyses are needed to understand and correlate tt with healthcare utilization and severity of illness. keywords surveillance; influenza; telephone triage; veterans references 1. yih wk, teates ks, abrams a, kleinman k, kulldorff m, pinner r, harmon r, wang s, platt r: telephone triage service data for detection of influenza-like illness. plos one 2009, 4(4):e5260. 2. van dijk a, mcguinness d, rolland e, moore km: can telehealth ontario respiratory call volume be used as a proxy for emergency department respiratory visit surveillance by public health? cjem 2008, 10(1):18-24. *cynthia a. lucero-obusan e-mail: cynthia.lucero@va.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e103, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts update from cdc’s public health surveillance & informatics program office (phsipo) james buehler*, laura conn, carol crawford and kathleen gallagher centers for disease control & prevention, atlanta, ga, usa objective to provide updates on current activities and future directions for the national notifiable diseases surveillance system (nndss), biosense 2.0, and the behavioral risk factor surveillance system (brfss) and on the role of phsipo as the “home” at cdc for addressing cross-cutting issues in surveillance and informatics practice. introduction the practice of public health surveillance is evolving as electronic health records (ehrs) and automated laboratory information systems are increasing adopted, as new approaches for health information exchange are employed, and as new health information standards affect the entire cascade of surveillance information flow. these trends have been accelerated by the federal program to promote the meaningful use of electronic health records, which includes explicit population health objectives. the growing use of internet “cloud” technology provides new opportunities for improving information sharing and for reducing surveillance costs. potential benefits include not only faster and more complete surveillance but also new opportunities for providing population health information back to clinicians. for public health surveys, new internet-based sampling and survey methods hold the promise of complementing existing telephonebased surveys, which have been plagued by declining response rates despite the addition of cell-phone sampling. while new technologies hold promise for improving surveillance practice, there are multiple challenges, including constraints on public health budgets and the workforce. this panel will explore how phsipo is addressing these opportunities and challenges. methods panelists will provide updates on 1) phsipo’s role in engaging health departments, the organizations that represent them, and cdc programs in shaping national policies for implementing the meaningful use program, 2) how the biosense 2.0 program is supporting growth in syndromic surveillance capacity, including its partnership with isds in developing standards for syndromic surveillance as part of meaningful use, 3) improvements that are underway in strengthening the nndss, including efforts to improve cdc’s support for health department disease reporting systems and to develop a “shared services” approach that could provide a platform for streamlining the exchange of information between health departments and cdc, 4) pilot development of internet-based panels of survey volunteers to supplement existing telephone-based sampling in the brfss and of approaches to extend brfss survey information through consentbased linkage of survey responses to selected measures recorded in respondents’ ehrs. results potential questions or discussion points that might arise include: what can or should be done to assure that the population health objectives of meaningful use are fulfilled? what are the lessons learned to date in leveraging investments in the meaningful use of ehrs to improve disease reporting and syndromic surveillance systems? what are the next steps in developing biosense 2.0 to assure that it leads to strengthened surveillance capacity at both state/local and regional/national levels? how can insights from the biosense redesign be applied to improve case reporting and other surveillance capacities? what is cdc doing to address states’ concerns about the growing number of cdc surveillance systems? how will national discussions about the future of public health affect the future surveillance practice? what can be done to assure the ongoing representativeness of population health surveys? is it feasible to link brfss responses to information obtained from ehrs? how can data from surveillance become part of the real-time evidence base for clinical decision making? conclusions the intended outcome of the panel is to foster a conversation between the panelists and the audience, to inform the audience about recent developments in phsipo, to obtain insights from the audience about innovations and ideas arising from their experience, and to generate new ideas for approaches to meeting the needs of public health for surveillance information. keywords surveillance; biosense 2.0; notifiable diseases; brfss—behavioral risk factor surveillance system acknowledgments the authors wish to acknowledge the many individuals from health departments, academia, and other agencies who have contributed to the ongoing operation and improvement of the nndss, biosense 2.0, and the brfss. references for more information about phsipo, see: http://www.cdc.gov/osels/phsipo *james buehler e-mail: jwb2@cdc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e98, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts disease surveillance and achieving synergy in public health quality improvement peggy a. honoré*1 and laura c. streichert2 1u.s. department of health and human services, washington, dc, usa; 2international society for disease surveillance, brighton, ma, usa objective to examine disease surveillance in the context of a new national framework for public health quality and to solicit input from practitioners, researchers, and other stakeholders to identify potential metrics, pivotal research questions, and actions for achieving synergy between surveillance practice and public health quality. introduction national efforts to improve quality in public health are closely tied to advancing capabilities in disease surveillance. measures of public health quality provide data to demonstrate how public health programs, services, policies, and research achieve desired health outcomes and impact population health. they also reveal opportunities for innovations and improvements. similar quality improvement efforts in the health care system are beginning to bear fruit. there has been a need, however, for a framework for assessing public health quality that provides a standard, yet is flexible and relevant to agencies at all levels. the u.s. health and human services (hhs) office of the assistant secretary for health, working with stakeholders, recently developed and released a consensus statement on quality in the public health system that introduces a novel evaluation framework. they identified nine aims that are fundamental to public health quality improvement efforts and six cross-cutting priority areas for improvement, including population health metrics and information technology; workforce development; and evidence-based practices (1). applying the hhs framework to surveillance expands measures for surveillance quality beyond typical variables (e.g., data quality and analytic capabilities) to desired characteristics of a quality public health system. the question becomes: how can disease surveillance help public health services to be more population centered, equitable, proactive, health-promoting, risk-reducing, vigilant, transparent, effective, and efficient—the desired features of a quality public health system? any agency with a public health mission, or even a partial public health mission (e.g., tax-exempt hospitals), can use these measures to develop strategies that improve both the quality of the surveillance enterprise and public health systems, overall. at this time, input from stakeholders is needed to identify valid and feasible ways to measure how surveillance systems and practices advance public health quality. what exists now and where are the gaps? methods improving public health by applying quality measures to disease surveillance will require innovation and collaboration among stakeholders. this roundtable will begin a community dialogue to spark this process. the first goal will be to achieve a common focus by defining the nine quality aims identified in the hhs consensus statement. attendees will draw from their experience to discuss how surveillance practice advances the public health aims and improves public health. we will also identify key research questions needed to provide evidence to inform decision-making. results the roundtable will discuss how the current state of surveillance practice addresses each of the aims described in the consensus statement to create a snapshot of how surveillance contributes to public health quality and begin to articulate practical measures for assessing quality improvements. sample questions to catalyze discussion include: —how is surveillance used to identify and address health disparities and, thereby, make public health more equitable? what are the data sources? are there targets? how can research and evaluation help to enhance this surveillance capability and direct action? —how do we identify and address factors that inhibit quality improvement in surveillance? what are the gaps in knowledge, skills, systems, and resources? —where can standardization play a positive role in the evaluation of quality in public health surveillance? —how can we leverage resources by aligning national, state, and local goals? —what are the key research questions and the quality improvement projects that can be implemented using recognized models for improvement? —how can syndromic surveillance, specifically, advance the priority aims? the roundtable will conclude with a list of next steps to develop metrics that resonate with the business practices of public health at all levels. keywords public health quality; metrics; framework references 1. honoré pa, wright d, berwick dm, clancy cm, lee p, nowinski j, koh hk. creating a framework for getting quality into the public health system. health aff (millwood). 2011 apr;30(4):737-45. *peggy a. honoré e-mail: peggy.honore@hhs.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e195, 2013 implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology stephen swanik* division of health policy and administration, public health informatics program, school of public health, university of illinois at chicago and departments of medical education and dentistry at advocate illinois masonic medical center, chicago, il. abstract objectives: the development of new information technology has significant effects on the health care system, and its implementation and the associated change management process can bring some positive changes and gains in understanding, but there are challenges with making the transition. these benefits and challenges are explored in the context of a hospital based dental department. additionally, the concept of the integration of oral health to overall systemic health is explored in context with an electronic medical records system implementation, and the american dental association’s recent recognition of dental anesthesiology as a clinical subspecialty. method: qualitative survey of attending dental faculty members of the department, who represent a broad range of dental specialties and experience in private practice, hospital based practice, teaching, and public health practice. results: the faculty survey yielded some consistent themes, ranging from enhanced information to make better diagnoses, to challenges in transitioning to emr, as well as concerns about data security and too much time and effort in front of a computer screen. discussion: a brief summary of the history of the stand-alone development of dentistry is given, which contributed to the separate development of dental emrs from hospital emrs. the various modalities of clinical care provided by the department of dentistry at advocate illinois masonic medical center, chicago, il are presented to give a scope of the areas of need a successful emr solution must meet in a hospital based dental setting. public health aspects are included in the discussion. conclusion: macro level health data sets (ie nhanes, state level datasets) have the potential to be expanded to include more thorough data, combining medical health data and oral health data in the same datasets. *correspondence: sswani3@uic.edu, steve.swanik@advocatehealth.com, sswanik15@yahoo.com mailto:sswanik15@yahoo.com implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi 1. introduction this writing will take a look at the considerations that go along with implementation of an electronic dental record system in a hospital based environment, with a discussion on the implications for public health that can come from a higher quality data yield that can result from a model consistent with integration of oral health and overall medical/systemic health. the department featured is the department of dentistry at advocate illinois masonic medical center in chicago, il, usa, a teaching hospital in the non-profit advocate-aurora health system. this is a large regional hospital network consisting of 27 hospitals and 500 sites of care across the states of illinois and wisconsin. the dental department at illinois masonic is the only full clinical dental department in this entire health system, and it is anticipating a transition to the epic wisdom dental emr platform in 2020. the department currently uses paper charts for clinical records and an electronic system for scheduling and billing. 2. department background and brief history: teaching/education and public health components the dental department was originally started in 1970 as a means to provide dental care for special needs children, benefiting from a close relationship with masonic charities through its affiliation with illinois masonic hospital. it developed a postgraduate general practice residency dental training program (gpr), and a dental practice. presently, the dental department is on the same standing in the hospital as the other clinical departments. it provides emergency on call services for the hospital, provides dental consults to inpatients, and sees patients with other medical comorbidities that make it medically risky for them to receive dental care in stand-alone dental practices. in 2000, it launched a mobile dental van program, providing dental care to a diverse set of sites including chicago public schools, thresholds psychiatric rehabilitation centers, and others. in 2016, the department aligned with the neighboring howard brown health center, an fqhc with a focus on providing healthcare to the lgbt community, to provide routine and complex dental care for its patient population. the department is launching a residency training program in dental anesthesiology, the newest recognized dental specialty [1] in july, 2019. when advocate health care and aurora care merged in 2018, system leadership decided to implement epic throughout the entire system. as of this writing, the dental department is slated to convert from paper based records to epic wisdom in june 2020. doi: 10.5210/ojphi.v11i2.10131 copyright ©2019 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi the department has had significant historical challenges with respect to its conversion to emr, yet it enjoys very broad success with its teaching programs and its public health programs. the department houses a longstanding postgraduate dental general practice residency (gpr) training program and will be launching the training program in dental anesthesiology in july 2019. at any given time, there are approximately 35 attending members of the department, most of whom have part time involvement ranging from activity such as teaching the residents a half a day a month, or as clinicians who perform dental cases in the hospital’s operating room. the gpr houses 9 residents and is a one year program in length. the dental anesthesiology program will house two residents per year and is a 3 year long training program. the structure of the department, considering its public health practice, its relationship with its hospital, and its upcoming conversion to an emr system lends to it being a good example with respect to strategically planning for public health utility of an emr system. it can additionally serve as a good example of dynamic change management in process, with positive takeaways and errors to learn from. the department has programs to provide care to different population modalities. it has a longstanding special patient dental care program, providing dental care for special needs patients, often times under iv sedation provided by a dental anesthesiologist and the dental residents. it has a mobile dental van which serves a variety of sites, including schools, assisted living facilities, psychiatric centers, and others on a monthly rotating basis. it also has a partnership with howard brown health center, a local fqhc which provides care primarily to chicago’s large lgbt community, to provide oral health care to its patient population. the launch of the dental anesthesiology program will additionally provide an avenue to increase departmental capacity to provide care for special needs patients. 2.1 major population groups served/sociodemographic analysis the department serves a diverse patient population, and has many programs in place to provide services to a diverse variety of underserved patients. the major population groups that are served by the department, in addition to a cohort of general ppo patients seeking routine dental care and hospital employees are as follows: the special patient dental care program --this program, as its name implies, provides dental care to special needs patients. these conditions include cerebral palsy, autism spectrum disorder, and others. many of these patients are treated under iv sedation guided by a dental anesthesiologist, dr. ken kromash. additionally, this is a significant component of training for the dental residents. with the upcoming addition of a dental anesthesiology training program, the department is anticipating increasing its capacity to provide care to special needs patients, particularly special needs children. hbhc and lgbt population --in 2016, howard brown partnered with the dental department to provide dental care for its patients. some of these patients are hiv +, some are transgender, implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi and many of them are lgbt. other literature exists [2,3] on the considerations of providing culturally competent care for the lgbt community, and this partnership aims to meet those ends. the hbhc partnership provides approximately 25% of the patient population of the clinic. medically compromised patients --the department, being hospital based, assumes oral health responsibility for the hospital inpatients. it sees medically compromised patients who require dental care that may be unsafe to provide in a private practice dental setting due to the medical condition of the patient. an example of this modality would be an inpatient requiring a complicated anesthetic intubation who receives a preoperative dental clearance or dental treatment from the dental department before the other medical treatment. mobile van populations --the department’s mobile van populations include a variety of patients from a variety of sites. some of the partnerships exist merely to meet a socioeconomic need, but some sites, such as psychiatric and geriatric sites, may present a coexisting medical need as well. each of these populations, for one reason or another, presents a potential need for clinical care that is a union of both medical care and dental care. 2.2 history and current status of emr conversion there have been two previous unsuccessful attempts to convert the department to emr in the last ten years. the most recent was an attempt at a conversion to eaglesoft, a major dental emr program in the market. the vendor and hospital technical teams were in the process of resolving security compatibility of a dental software program that was not developed with a primary focus of being implemented in a large hospital system, and the business contracts were in the process of being developed, signed, and executed. this project was aborted when advocate health care merged with aurora health care, and the decision was made to convert all advocate emr systems to epic systems, inc. – meaning of course that the dental program became contractually obliged to utilize epic wisdom, the dental module for the epic software platform. this transition is now scheduled to occur in 2020. the challenges associated with security capability can be traced at least somewhat back to the concept of the historical division of oral health from overall systemic health. as dental emr software systems were initially designed, the concept of implementing them into hospital-based environments was not the first priority, and conversely when hospital emrs were developed, the dental/oral health components were not the first priority. a previous attempt in around 2014 – 2015 also failed, but this failure was specifically at the departmental level, as clinicians and administrative management were unable to successfully collaborate and agree on an emr system. what was particularly telling about this is that the postgraduate residents in the educational training program, though highly wanting to utilize emr, strongly objected to the chosen product, in part because “it is apparent that this system was chosen based on convenience and the long-term relationship built with a current vendor. we feel that even implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi though the institution wants to respect a long-term relationship with the vendor, the software offered does not satisfy the needs of the organization.” 3. intersection between emr system and physician there already exists significant literature on the topic of the relationship between the physician, the patient and the emr system. challenges that still exist include the fact that many physicians feel burdened by certain aspects of the emr system, as examples they spend much more time performing administrative tasks, and many of them feel that during patient encounters they are spending too much time looking at a computer screen and not interacting with patients. schulte and fry recently published a summary [4] of this conversation in medscape. some of these challenges were reported in a survey conducted of the department teaching faculty. 4. brief summary of the history of the divide between oral health and systemic health in the us another factor to look at is the relationship between oral health and systemic health in the u.s. health system. this has been a longstanding “fait accompli” in the us. however there are current initiatives to move towards a more full integration of oral health and systemic health, as biologically these two systems are fully intact and interact with each other – a dental abscess leading to an infection serving as a routine example. mertz wrote a summary [5] in 2016 of how we got to where we are today in health affairs. some of the highlights of this include the historical routes of “barber-surgeons,” “distinct from physicians, nurses, and pharmacists.” as such, dental schools were independently established after the development of medical schools. dental insurance was not originally packaged with health or medical insurance and was developed as a separate product line from medical insurance. the clinical delivery system was designed separately and distinctly from medical systems; dental practice and hygiene teams have their own separate training apparatuses. and though the affordable care act took a stab towards pediatric dental coverage, it did not significantly address dental coverage for adults. mertz also touches a key point for this writing, that “electronic dental records are rarely interoperable with medical records, limiting oral and systemic health research, and dentistry lacks a fully deployed set of diagnostic codes, stymieing comparative effectiveness research.” simon advocates in the ama journal of ethics [6] for integration and increased collaboration as a way to promote health equity, mentioning areas in which physician training can incorporate areas of oral health education, and vice versa, but does not cover the role of an emr. the american dental association additionally has invested some resources exploring the integration of oral health with overall systemic health and has produced literature on this topic. its chief economist, dr. marko vujicic, wrote an editorial [7] in the journal of the american dental association about the topic. some key topics he addressed include defining and systematically measuring oral health, and reforming the care delivery model. implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi an area of high significance with respect to both oral and medical care is the presence and slated expansion of dental anesthesiology in the department. in 2016, giovannitti et al wrote a detailed summary of the specialty [8] and its history. this article covers a brief history of the discovery of anesthesia, and the clinical relationship between dentistry and anesthesia. it also gives a history of the development of dental anesthesiology training programs, and a detailed and thorough explanation of the educational standards. it then goes into a discussion of need, growth, and challenges of the discipline. as the topic of this article was about the specialty of dental anesthesia, and highly focused on clinical training standards, it did not address emr systems. an analogy can be made however between the clinical integration of oral and medical health brought about by dental anesthesiology and the digital integration of digital oral health and digital medical health brought about by an emr system encapsulating both. a key takeaway from this writing is that an integrated emr can be used as a tool to drive the integration, and that this integrated knowledge is beneficial for patient care and ultimately public health. 5. survey of dental faculty there are approximately 35 faculty members on the medical staff at aimmc, and they were all asked to participate in a voluntary survey about their experiences and thoughts with emr. the survey focused on the public health aspects of an emr and the clinicians’ thoughts about data interoperability. the goal was to obtain a minimum of 10 quality responses, and this was achieved. the faculty provided many high quality comments, and these responses converged over some major themes and reinforced the necessity to further address those themes – particularly themes such as user friendliness, data security. the survey questionnaire was developed with the help of drew gripentrog, dmd, who is an alum of the gpr program and a current attending faculty member. there were 12 responses, and these responses yielded some consistent themes. these were the questions asked in the questionnaire: 1. what in your opinion are the most important features/characteristics of an emr system itself? 2. do you currently use an emr in private practice? is it cloud based? 3. have you ever been involved in the history of an implementation/conversion in either a private practice or a hospital/school-based environment? what are some key takeaways from that experience? 4. what do you find to be the most important oral health considerations that emr can help to identify or address? 5. do you see any key public health insights that can be derived from emr? 6. do you notice any trends among population groups with respect to any specific oral health concerns – whether those population groups are age, income, ethnicity, geographic locations, or others? how does emr facilitate identifying trends? implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi 7. what characteristics do you most hope to see in the future dental emrs? 8. how significant do you find data transmission between sites or other colleagues to be with respect to care? things such as patient referrals, transfer of x-rays from one sight to another sight? what type of information transfer do you find the most important to be for effective care? 9. if you could integrate your private practice’s emr and its respective data with any hospital systems you are affiliated with, would you? what do you see as potential strengths of this? what concerns would you have? 10. has the opioid crisis affected your clinical practice and if so how? here are some selected responses with some comments: “i converted my private pediatric dental practice in the chicago suburbs from a paper based charting system and computerized billing (on an antiquated dental software program) with digital radiography to a completely paperless integrated system (emr). it took 6 months, i had to purchase a new $10,000 server, and lots of extra manpower to scan all that paper and convert the accounts from one computer system to another. choose the new software system wisely (do your research for ease of use and conversion support), be sure your it people are aware of your storage needs first, and be sure your office staff have proper training, motivation, and take ownership of the project. set goals and achieve them.” this is a response to question 6, aligning with the concept of utilization of emr to pull reports for public health purposes. “yes perio in the hispanic population. a lot of enamel hypoplasia in our geographic location. yes much easier to pull reports. this is also good for financials and seeing public health trends” this comment was in response to question 7, regarding future potentials of emrs. an interesting catch with respect to the medical history and how further development can still come for more accurate diagnostic information in medical histories. “compatibility with their physicians would be amazing so that the medical history wouldn't be self reported instead we could see what is really going on and what medications they are taking, how well they are controlled, etc.” another survey: “identification of oral habits can be correlated to race and culture, caries risk assessment and anticipatory guidance can be quite related to social economical status.” implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi “it will be very beneficial if any oral health provider could somehow communicate within the emr system regardless of the hospital network they belong to.” this comment ties into the large historical conversation of it development and interoperability as it relates to the proprietary features of computer systems: historically apple products and microsoft pcs and products couldn’t talk to one another – and this change has started to become more commonplace in large part due to consumer demand and expectation. this perhaps may be area where health care can learn from history in other segments. if the system develops so that emrs establish a de factor oligopoly, then the question of proprietary rights and effective transmission of data across competitors will need to be addressed. another survey: “yes. data collection. being able to monitor disease incidence, prevalence, and treatment outcomes. being able to determine quality measures for value. being able to look at trends over time. being able to share information with non-medical folks who can help with things like nutritional counseling, smoking cessation programs, etc.” “i hope to see a way to integrate with medical emr systems. i hope to be able to refer directly to other colleagues like behavioral therapists, occupational therapists, physical therapists, nutritionists, drug and smoking cessation counselors, pharmacists. i'd want those colleagues to see what dental treatments we were providing and why. i'd want my dental treatment to need a diagnostic code so other providers can know why i'm performing certain treatments. i'd want my dental diagnostic code to have to link to a medical code when necessary. for example, if i've diagnosed periodontal disease, i'd want a medical diagnostic code that connects when relevant. for example, if a patient has periodontal disease and diabetes, those therapies should link together somehow in the emr so that we can track the outcomes of treatment.” this comment is a very broad comment, touching on many important aspects, with an emphasis on coordination of care. this respondent also comments on data transferability, from the perspective of providing complete care to patients: “it's necessary but not a modern system. you'd think that as easy as it is to take a photo on my phone and share it with the world automatically, i should be able to transfer data seamlessly without having to email attachments, etc. if i'm treating a dental patient, everything implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi that i do, any images, etc, should automatically be in the patient's medical record and accessible. the physician should get a notification when patients are visiting the dentist and vice versa.” another response re-emphasized the importance of transferability of data: “the most important feature of any emr system is the ease of portability of the records. i think that someday in the future, patients will be the owners and maintainers of their own health records and they can take them with them wherever they go. it is theoretically easier for doctors/hospitals to transfer records digitally if the information is available. if patients are the keepers of their own health records, and it is stored digitally on a chip, then in an emergency, the records can be available even if the patient is not able to communicate. that can save lives.” “i think it will be easier to identify population health statistics from emr.” “among my patient population, across all the categories you cited, people want to save their teeth and have them looking good. nobody likes flossing! emr can facilitate identifying the trends because all the parameters are readily available within a software program.” the theme of the difficulty of making the emr systems compatible with physician workflow was also mentioned: “i want them more user friendly so i don't have to click as many boxes or open as many windows to make an entry.” “it is easier and often faster to get patient records. that can impact patient care, especially when you have the patient in the office and you need a record from another office immediately. the most important information i have found to be useful for patient care has been images, either radiographic or otherwise.” – conversation about which information is most important for clinicians “i don't know if i would integrate my emr data with a hospital system. there would be security concerns. also, i think the only time it would be truly useful is when there is a crossover between medicine and dentistry, such as cancer of the head and neck. potential strengths are better care of the patient.” “the biggest surprise that i have from emr is that i thought it would make my life easier and i would be spending less time on records. it is completely the opposite. i am spending more time on them and it implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi is making the practice of health care much less enjoyable. and now i have to worry about data security a lot more. there a many more ways phi can be obtained with an emr than with a paper record.” there were some key responses regarding conversion to emr. “yes, was involved in transitioning from paper charts to emr in dental school. the experience was pretty bumpysome faculty even chose to retire over it instead of learning the new system. they tried to implement "superusers" who were trained ahead of time, but there were either not enough of these, or these users didn't really know how to work the software either. i think a soft release would've helped, but we all went live on the day they picked and no one really did their homework of knowing how to work it. a lot of money was lost with not walking out the correct procedures or knowing how to bill. it was a big hassle.” “in my private practice, i converted from paper charts to emr. the key takeaways for me were: 1) you just have to make the change. no looking back--just walk to the edge and jump! 2) it will be stressful, but there are advantages. 3) it won't make your life that much easier. 4) i am spending more time on records now than i was before. 5) it costs a lot 6) there are more threats to security with emr than with paper.” “if emr can help to shorten appointment lengths, or make sure to remind patients of appointments and keep them on a recall schedule, then that is very useful. it also makes charting and keeping an accurate history of visits and services much easier and clearer.” this comment addressed the theme of the utility of emrs and digital systems for simplifying and reducing error in basic routines. “emr over time should be able to pick up trends in services provided or reasons for visits. good emr should be able to run reports looking at almost any variable, be is by service, or zip code, or utilization, etc. the possibilities are endless, and this is something you just couldn't do with paper charting.” this respondent was aware of a common theme in information technology circles, “garbage in, garbage out,” or “gigo.” “people tend to be wanting implants more, but this also varies greatly with ses. people tend to be wanting full mouth makeovers i.e. big veneer cases less (due to economic conditions/uncertainty) implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi again, a good emr should be able to run almost any report over a defined period of time with respect to procedure codes and zip code. unfortunately you don't usually have income data, but you do have age, race, ethnicity, zip code, etc. however, emr reports are only as good as the data and accuracy of data put in.” “i would love to be able to transfer a prescription electronically to any pharmacy. i would love to be able to send an xray or cbct scan electronically and securely through emr. getting records from another office is usually a sadly difficult thing to do. i would love to be able to click and send over a digital referral to a specialist and know they got it.” this is an important comment, particularly as the clinical discipline of dentistry is heavily dependent on the general dentist’s ability to develop a specialty referral network, and to efficiently communicate patient need between specialists. “this is very difficult usually. either the patient forgets, the e-mail gets lost, the other office forgets, sometimes the requests are denied, etc. it's almost always easier to just take your own new xrays. even if you get previous xrays, sometimes the quality is so poor due to the format, they are essentially useless.” question 9, the question about integrating a private practice’s dental records with a hospital system, yielded some interesting responses as well. “i don't think integrating my private dental practice with a hospital system in particular would be that useful, but maybe if there was a generic third party portal to transfer data on an as needed basis that could be useful.” “i understand that epic, the hospital's computer system, has a dental component but no one uses it. typically i use epic to write operative reports for patients treated under general anesthesia in the or or emergency patients in the er. if we need to transfer information to a physician's office, we send it via encrypted email. if we need to access something from epic, the practice owner has remote access in his office. i don't think mds would understand our charting systems and dental procedures (in our dental software or in the dental portion of epic) enough for it to be beneficial without our interpretation.” “yes! absolutely. the only concerns would be that we would end up seeing too much but really everything is applicable since we take care of the whole person.” implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi 6. public health considerations there already are existing sources for oral health data. examples of these include the dental quality alliance [9] (dqa), affiliated with the ada, and the center for disease control’s national health and nutrition examination survey (nhanes). the cdc additionally has a website [10] set up to explore oral health data by location, https://www.cdc.gov/oralhealthdata/. the state of illinois department of public health has oral health resources as well [11]. however, most of these are stand-alone data sets focusing essentially exclusively on oral health, and as such they do not completely capture the corresponding medical status of the populations in the same way as a fully-integrated medical record consisting of both medical data and oral health data could. the opportunity for the future is the upcoming potential to capture and use the population level data and metadata generated from hospital based dental emr systems and other to be developed systems to elucidate further understanding. oral health information can now be directly linked to and keyed with corresponding medical data, allowing for more opportunities clinical research, and to inform policy makers, advocates, and other stakeholders with strategies to improve overall health. examples such as the link between periodontitis and cardiovascular health can now be much further explored, as can demographic, and even geographic based data be generated. 7. concluding remarks dental emr conversions have happened before, and literature [12] already exists about the challenges associated with this. now, we take the next steps by looking at the integration of a dental emr in a hospital based environment. this distinction opens up the discussion to other important areas beyond just the technical specifics of an emr system. these areas include the applications and broader utility that can come from the use of the implemented system as a tool to provide insight into the systemic integration of oral health into total health. an integrated emr is posited as a tool to better increase population health. as hospital based dental practices are equipped to provide oral health to a variety of dentally underserved populations the subsequent aggregated metadata resulting from this treatment can in the future be used to broaden the public health discourse. many of the survey comments show that faculty are already inherently aware of many of the strengths and current challenges with emr. key concepts repeated multiple times include the benefit of facilitated aggregation and utility of population level data, and the subsequent generation of metadata enabled by deployment of emr, yet the challenges of security, user friendliness, and the gigo moniker are mentioned as well. a key related takeaway is both the need and the potential for the development of a standardized dataset that contains both oral and medical aspects, as the currently existing oral health datasets are severely lacking commensurate medical data. dental anesthesia can serve as a clinical example of oral and systemic health integration – the utilization of anesthesia specifically for the dental context is a clinical example of this integration. implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi with the recent specialty status recognition of dental anesthesia by the american dental association, this specialty is in a position to grow, and this development will also contribute to the conversation. this will be another area in which emr systems can play a role. that the dental department at illinois masonic is still using paper charts in its dental clinic is a clear indication of the importance of successful change management strategies, and the influence of multiple factors and needs affecting multiple stakeholders. from a certain perspective, it can be deemed problematic that a clinical department significantly involved with medical care does not have an emr system in 2019. nevertheless, this example shows the often surprising challenges that come with the development and implementation of new technology. 8. limitations the limitations in this writing stem from the fact that it explores only one department in one hospital system. additionally, that department has yet to fully launch some key features -the dental anesthesiology training program has a begin date of july 1, 2019, and the full emr conversion is scheduled for june, 2020. there is an anticipated ramp up process in the future, however as of right now there has yet to be a critical mass of numbers developed for extended datasets discussed. secondly, the investigation for this was very focused on human experiences and interactions. though valuable, they should be framed and taken into context as such. individual experiences and perspectives are not empirically tested; they are only recorded and reported. another important consideration is that only dentists were surveyed for this project, so the perspectives of computer engineers, software developers, and so forth are not covered. a next step could be to obtain insight from those personnel. suggested readings schleyer, t., song, m., gilbert, g. h., rindal, d. b., fellows, j. l., gordan, v. v., & funkhouser, e. (2013). electronic dental record use and clinical information management patterns among practitioner-investigators in the dental practicebased research network. the journal of the american dental association, 144(1), 49-58. liu, k., acharya, a., alai, s., & schleyer, t. k. (2013). using electronic dental record data for research: a data-mapping study. journal of dental research, 92(7_suppl), s90-s96. acharya, a., shimpi, n., mahnke, a., mathias, r., & ye, z. (2017). medical care providers’ perspectives on dental information needs in electronic health records. the journal of the american dental association, 148(5), 328-337. rindal, d. b., kottke, t. e., rush, w. a., asche, s. e., & enstad, c. j. (2015, december). implementation of an electronic dental record tool to increase referrals to a tobacco counseling quit line. in implementation science (vol. 10, no. 1, p. a6). biomed central. implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi brent, b. k. (2018). a survey of the implementation and usage of electronic dental records and digital radiographs in private dental practices in mississippi. tokede, o., ramoni, r. b., patton, m., da silva, j. d., & kalenderian, e. (2016). clinical documentation of dental care in an era of electronic health record use. journal of evidence based dental practice, 16(3), 154-160. sheikhtaheri, a., zarei, a., & ahmadi, m. (2018). a comparative study on the features of specialized electronic dental record systems. journal of health administration (jha), 20(70). sidek, y. h., & martins, j. t. (2017). perceived critical success factors of electronic health record system implementation in a dental clinic context: an organisational management perspective. international journal of medical informatics, 107, 88100. mertz, e. a. (2016). the dental–medical divide. health affairs, 35(12), 2168-2175. murphy, d. r., meyer, a. n., russo, e., sittig, d. f., wei, l., & singh, h. (2016). the burden of inbox notifications in commercial electronic health records. jama internal medicine, 176(4), 559-560. goh, w. p., tao, x., zhang, j., & yong, j. (2016). decision support systems for adoption in dental clinics: a survey. knowledge-based systems, 104, 195-206. yi, y., lee, j., yi, h., asher, s., feldman, l., rivas-morello, c., ... & ross, e. (2015). variables affecting general anesthesia time for pediatric dental cases. pediatric dentistry, 37(7), 508-512. mandel, j. c., kreda, d. a., mandl, k. d., kohane, i. s., & ramoni, r. b. (2016). smart on fhir: a standards-based, interoperable apps platform for electronic health records. journal of the american medical informatics association, 23(5), 899-908. goldstein, b. a., navar, a. m., & pencina, m. j. (2016). risk prediction with electronic health records: the importance of model validation and clinical context. jama cardiology, 1(9), 976-977. yüksel, b., küpçü, a., & özkasap, ö. (2017). research issues for privacy and security of electronic health services. future generation computer systems, 68, 1-13. colaianni, c. a., levesque, p. a., & lindsay, r. w. (2017). integrating data collection into office work flow and electronic health records for clinical outcomes research. jama facial plastic surgery, 19(6), 528-532. kharrazi, h., chi, w., chang, h. y., richards, t. m., gallagher, j. m., knudson, s. m., & weiner, j. p. (2017). comparing population-based risk-stratification model performance using demographic, diagnosis and medication data extracted from outpatient electronic health records versus administrative claims. medical care, 55(8), 789-796. ritwik, p., massey, c., & hagan, j. (2015). epidemiology and outcomes of dental trauma cases from an urban pediatric emergency department. dental traumatology, 31(2), 97-102. https://www.ncbi.nlm.nih.gov/pmc/articles/pmc1430363/ macek, m. d., manski, r. j., vargas, c. m., & moeller, j. f. (2002). comparing oral health care utilization estimates in the united states across three nationally implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi representative surveys. health services research, 37(2), 499–521. doi:10.1111/1475-6773.034 references 1. solana k. (2019, march 12). ada news: anesthesiology recognized as a dental specialty. retrieved april 20, 2019, from https://www.ada.org/en/publications/ada-news/2019archive/march/anesthesiology-recognized-as-a-dental-specialty 2. mcewing em. 2017. delivering culturally competent care to the lesbian, gay, bisexual, and transgender (lgbt). population. 3. felsenstein dr. 2018. enhancing lesbian, gay, bisexual, and transgender cultural competence in a midwestern primary care clinic setting. j nurses prof dev. 34(3), 142-50. doi:10.1097/nnd.0000000000000450. pubmed 4. death by 1000 clicks: where ehrs went wrong. (2019, march 19). medscape. retrieved from https://www.medscape.com/viewarticle/910608?nlid=128907_5204&src=wnl_dne_190320_ mscpedit&uac=145970pn&impid=1912878&faf=1 5. mertz ea. 2016. the dental–medical divide. health aff. 35(12), 2168-75. pubmed https://doi.org/10.1377/hlthaff.2016.0886 6. simon l. 2016. overcoming historical separation between oral and general health care: interprofessional collaboration for promoting health equity. ama j ethics. 18(9), 941-49. pubmed https://doi.org/10.1001/journalofethics.2016.18.9.pfor1-1609 7. vujicic m. 2018. our dental care system is stuck: and here is what to do about it. j am dent assoc. 149(3), 167-69. pubmed https://doi.org/10.1016/j.adaj.2018.01.006 8. giovannitti ja, montandon rj, herlich a. 2016. the development of dental anesthesiology as a discipline and its role as a model of interdisciplinary collaboration. j dent educ. 80(8), 938-47. pubmed 9. (n.d.). retrieved from https://www.ada.org/en/science-research/dental-quality-alliance/aboutdqa 10. oral health data. (2018, july 27). retrieved from https://www.cdc.gov/oralhealthdata/ 11. oral health. (n.d.). retrieved from http://www.dph.illinois.gov/topics-services/preventionwellness/oral-health https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29659418&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27920303&dopt=abstract https://doi.org/10.1377/hlthaff.2016.0886 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27669140&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27669140&dopt=abstract https://doi.org/10.1001/journalofethics.2016.18.9.pfor1-1609 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29478442&dopt=abstract https://doi.org/10.1016/j.adaj.2018.01.006 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27480705&dopt=abstract implementation of an emr system for a comprehensive dental service within a large regional hospital network: challenges and opportunities presented by the introduction of new technology online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(2):e19, 2019 ojphi 12. sidek yh, martins jt. 2017. perceived critical success factors of electronic health record system implementation in a dental clinic context: an organisational management perspective. int j med inform. 107, 88-100. pubmed https://doi.org/10.1016/j.ijmedinf.2017.08.007 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29029696&dopt=abstract https://doi.org/10.1016/j.ijmedinf.2017.08.007 citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi citizen science models in health research: an australian commentary ann borda1*, kathleen gray1, laura downie2 1health and biomedical informatics centre faculty of medicine, dentistry and health sciences the university of melbourne melbourne, vic 3010, australia 2department of optometry and vision sciences faculty of medicine, dentistry and health sciences the university of melbourne melbourne, vic 3010, australia abstract this qualitative review explores how established citizen science models can inform and support meaningful engagement of public in health research in australia. in particular, with the growth in participatory health research approaches and increasing consumer participation in contributing to this research through digital technologies, there are gaps in our understanding of best practice in health and biomedical citizen science research to address these paradigm shifts. notable gaps are how we might more clearly define the parameters of such research and which citizen science models might best support digitally-enabled participation falling within these. further work in this area is expected to lead to how established citizen science methods may help improve the quality of and the translation of public engagement in health research. keywords: citizen science, community based participatory research, crowdsourcing, public health corresponding author: ann borda, health and biomedical informatics centre, faculty of medicine, dentistry and health sciences, the university of melbourne, parkville, victoria 3010, australia; aborda@unimelb.edu.au* doi: 10.5210/ojphi.v11i3.10358 copyright ©2019 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. introduction global growth in participatory research approaches to address complex health challenges is being progressively supported by online platforms, tools and digital sensing devices. the mainstreaming of this form of public engagement is at the forefront of national research and health policy programmes [1,2]. citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi within australia, “consumer and community participation” in research is part of a paradigm shift leading to the increasing active involvement of the public (i.e. consumers and community members) and researchers working together to make decisions about health research priorities, policy and practice [3]. in the findings of a 2018 australian-wide survey (= 868 respondents) on the perceptions of such engagement, the majority of survey respondents (97%) reported that public involvement has meaningful value to all phases of health and medical research. the survey findings also acknowledged that public involvement is complex and differs across the research spectrum, thus requiring models that are flexible and have applicability in diverse research situations [4]. in this context, the authors provide an overview of the applicability of potential models which might be considered by participatory health researchers in australia. specifically, public engagement in health and biomedical research is increasingly being influenced by the paradigm of “citizen science”, that is, active participation in research teams by members of the general public with no formal training in the field of research concerned [5-7]. citizen science as an approach for public engagement in research dates back well-over a century in some fields of research, for example, natural history, where the us audubon society’s christmas bird count began in 1900 [5]. citizen science activity has dramatically increased in the 21st century, influenced by societal and technological changes and participatory democracy. critically, it has enabled the large-scale collection and processing of scientific data and widespread dissemination of scientific knowledge and discoveries, notably in environmental sciences, ecology, and astronomy [8-10]. citizen science traditions in australia australia has long-standing traditions in citizen science and public participation in scientific enquiry. although the term “citizen science” came into prominence in the mid-1990s [5,6], citizen science in australia has been established by grassroots activities and bottom-up approaches. over a century ago, ferdinand von mueller (1825-1896), the reputed nineteenth century australian botanist advertised for the assistance of “lady plant collectors” across the country in one of the most notable citizen science projects. von mueller inspired an estimated 1300 volunteers to participate in the project in submitting specimens, which culminated into informing the seven volume flora australiensis published between 1863 and 1878 by george bentham [11]. australia is also a country holding unique local indigenous traditional knowledge that spans thousands of years of ecological monitoring and empirical mapping of phenomena that precedes defined citizen science and participatory research approaches [12,13]. indigenous knowledge and citizen science represent parallel discourses which have emerged in both southern and northern hemispheres [14]. the australian citizen science association (acsa) was established in 2014 following national consultations in recognition of the need for a community of practice to support the expanding field of citizen science in australia, and aligned with international advancements [15]. around this time, citizen science practices were formalised through communities of practice organisations in europe with the establishment of the european citizen science association (ecsa) and in the usa, citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi through the citizen science association (csa). the launch of acsa in 2015 was particularly bolstered by a white paper occasional paper on citizen science by the then chief scientist of australia [16]. acsa has adapted the ecsa principles of citizen science as its working principles that highlight the common good aspects of involvement of citizens in scientific endeavours which, for example, can generate new knowledge or understanding, provide benefits to science and society, support reciprocity, ethical approaches and publicly available results [17]. australia has fostered an increasing number of citizen science developments, most visibly in the field of biodiversity as exemplified by one of the largest nation-wide platforms of its kind, the atlas of living australia (ala). launched in 2010, the ala is a collaborative, national project that aggregates biodiversity data from multiple sources and currently holds data on over 120,000 individual species in the ala database [18]. the ala also hosts the australian citizen science project finder online database, with over 600 projects across australia [19]. opportunities for large-scale projects in australia have been made possible as citizen science is associated with increasing funding, infrastructure and support at different levels of government [20]. citizen science models of participatory health research health and biomedical citizen science is not readily defined as a separate practice or associated with a specific framework or schema, although the field is increasingly identified with a number of engagement models [21-24]. projects involving human health and participants can be viewed as citizen science among various forms of community-based participatory research, action research, patient and public involvement (ppi), self-quantification, crowdsourced health research, among other practices [15,23-26]. the commonalities are associated with an enabled and widening participation, most often supported by ict and digital and social media which have rapidly increased the range of people who can participate in health and biomedical data collection and, where appropriate, data analysis and other tasks [25,27]. these technological developments, combined with policy initiatives and consumer empowerment, have also given rise to new ways of activation, for example, in health advocacy, health self-management and reporting, and research design. generally, citizen science projects have been differentiated according to the extent of responsibilities that participants undertake for research activities, such as collecting and analysing data (contributory) and interpreting and disseminating results (collaborative) [6,8]. in most studies, citizen projects are typically instigated by professionally trained researchers in which participants are supporting tasks in a research process; however, community scaled participatory research projects, for example, can be a cooperative activity. in the latter example, a higher level of ownership may be associated with co-creation in which researchers and members of the public work together across research processes [6,8,28]. a broadening of this framework is citizen-led or extreme citizen science approaches, which aim to provide tools and methods to enable communities to develop participatory research projects to address issues that concern them [28,29]. meaningful participation, according to kelty et al [30], engages participants along seven dimensions: for example, receiving an educative dividend; involvement in decision-making and goal-setting; and having control or ownership of the resources produced by participation. there citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi should be a “collective, affective” experience of participating in order for participants to feel they are part of something greater than themselves [30]. in community based participatory research (cbpr), for instance, participants can provide researchers with advice concerning the design of research projects, potentially including the research goals, design of survey instruments, recruitment, and data interpretation and dissemination, among other activities [31-33]. the need to ensure ownership and control over local knowledge is highly relevant in situations of cbpr that can inform wider citizen science practices [32-35]. such multidimensionality of participatory activities in health research is necessarily expressed in different schemas. engaging large numbers of the public is often undertaken through crowdsourcing [36] which has been the most visibly applied citizen science method to the fields of health and biomedical research [25,27]. crowdsourced health research studies have been defined as the nexus of three contemporary trends: “citizen science, crowdsourcing, and medicine 2.0” [37]. crowdsourced tasks can be quite wide-ranging but mainly rely on the use of digital tools and platforms for use by the public in undertaking specific tasks [27]. for instance, volunteers are classifying images of the m. tuberculosis bacteria as part of the bash the bug project hosted on the zooniverse citizen science web portal, and have reached over one million classifications [38]. crowdsourced data processing can further involve both lay-people and those knowledgeable in a discipline, particularly where complex tasks, e.g. forms of annotation, relational tasks or problemsolving are applied. cochrane crowd, the citizen science platform of cochrane, a global network promoting evidence-informed health decision-making by producing high-quality accessible systematic reviews, is comprised of a crowdsourced community of volunteers who undertake supporting tasks such as randomised controlled trial (rct) identification in research papers [39]. crowdsourced health research projects can further target health conditions in which participants undertake self-reporting using mobile apps and wearable sensors [40]. health promotion is increasingly another context in which the engagement of the public through self-reporting and data collection is contributing to forms of public health research and policy [34,35]. critically, in a public health landscape, citizen science can support localised participatory action research and “participatory epidemiology” leading to the capture of qualitative and quantitative epidemiological information contained within community observations, including traditional oral history [35]. the use of gamification – often termed as “serious games” is a digitally-enabled method to support participatory action research. for example, spotlab is an example of a disease surveillance platform that uses gaming and mobile phones turned into low-cost microscopes to provide collective diagnosis of global health diseases, such as malaria diagnosis [40]. serious games developed by professional scientists, such as the multiple sequence alignment online game, phylo developed at mcgill university (montreal, canada), are further instances of contribution by the public in problem-solving tasks as in this example of finding ways of sequence arrangement of dna and rna to identify regions of similarity [41,42]. there is a concurrent rise of digitally-engaged and activated citizens, alternatively called “biocitizens” by some in the health research literature and to distinguish from other types of nonhealth related participation, especially at the individual level [37,43]. the notion of biocitzenship firstly emerged through the concept of biosociality [44] – that is the making of connections citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi between biotechnology and citizenship. recently the concept of “participatory biocitizen” coined by melanie swan [37] refers to an activated individual and as a means to realise personalized medicine by sharing life-logging and self-quantification data through social media platforms. selfquantifiers, in particular, represent high levels of activation that may motivate these individuals to independently mobilise citizen scientists and/or approaches [43,45,46]. these approaches are often typically outside of the instigation of organised health professionals or scientific organisations, as in the case of biohackers [43]. in the us, “people powered research networks” (pprn) are leading on the sharing of quantifiable data, exchanging experiences on treatments, and searching for clinical trials on online platforms [45,47]. examples include the personalized health and research network, patientslikeme [48], and advocacy network iconquerms which is focused on the multiple sclerosis (ms) community [49]. commercial and government-led research partnerships provide another means by which public engagement can be supported. for instance, sage bionetworks and the university of rochester partnered with apple researchkit to study the lifestyle of 17,000 parkinson’s disease patients in the mpower initiative [50]. the nation-wide $215 million precision medicine initiative all of us in the u.s. aims to build a large-scale research platform between public and private sectors, calling for one million volunteers to contribute their health data [51]. other opportunities are provided through joint collaborations between the public and healthcare organisations in co-creating knowledge. one example is the sarroch bioteca foundation established in 2012 in pursuit of a “citizenveillance on health” project in italy [52]. among the national agencies at the forefront of the development and promotion of public and community involvement in health research include involve in the uk [53]. involve is a government funded programme established in 1996 and is part of, and funded by, the national institute for health research, to support active public involvement in the national health service (nhs), public health and social care research. related initiatives are the patient centred outcomes research institute (pcori) of the national institutes of health in the u.s. and the strategy for patient oriented research (spor) of the canadian institutes of health research [1,4]. the australian context aligning with international developments, australia is implementing various approaches to strengthen public involvement in health research. the national health and medical research council (nhmrc), for instance, provides national guidelines for responsible research practices and advocates for appropriate public involvement in research [3]. the consumer and community health research network based in western australia is an example of a practical implementation of a service which is leading programs and resource development to promote awareness and support [54]. the network is among several agencies comprising the australian health research alliance (ahra) which was involved in undertaking a major review project in 2017-2018, including the deployment of an australia-wide survey to capture the extent and nature of consumer and community involvement across ahra member organisations. recommended priorities include the development of guidance on incorporating public involvement across the research life cycle, and associated tools and resources to enable and support partnerships, as well as other capacity building initiatives, such as training [4]. citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi as a complementary direction to these priorities, a review of the application of existing citizen science models to participatory health research has identified several examples for the purposes of this commentary. the selected projects are based or led from within australia and focus on forms of digitally-enabled public participation in health research which use publicly accessible ‘citizen science’ tools and platforms. examples draw on the models of contributory (e.g. participation via data collection and processing), collaborative (e.g. public involvement in refining research questions, analysing data, and/or disseminating findings), co-creation (e.g. researchers and members of the public working together across key research processes), and extreme citizen science in which researchers provide tools and methods to enable communities to develop their own participatory research projects [6,8,28]. projects are thematically clustered using a public health research lens as follows: indigenous science and environmental health in the context of indigenous participation and environmental health, the aboriginal concept of health appears as part of a health impact assessment approach by the australian indigenous doctors’ association [55] and mentioned as an exemplar in a prominent position paper on citizen science and public health [56]. several indigenous partnership projects are hosted in the atlas of living australia database (ala), and discoverable in the acsa project finder. for instance, the tracks app of the indigenous desert alliance (ida) is an ecological science mobile app co-created with stakeholders to support the involvement of aboriginal people and indigenous ranger groups in remote areas [57]. the tracks app supports the collection of information on native animal tracks and other signs, such as scats, diggings, burrows, bones and feathers. the commonwealth scientific and industrial research organisation (csiro), an independent australian federal government agency responsible for scientific research, is supporting different citizen science solutions in a number of environmental health projects. the eye on water project is an example of a digitally-enabled participation project using a water quality monitoring app to collect data about water changes around australia due to climate change phenomena [58]. the project routinely involves school students who assist in making physical and chemical measurements, as well as providing digitally captured data, alongside members of the volunteer public. researchers are using the datasets to compare water quality data with satellite-derived ocean colour or coastal/inland water feature data [58]. an example of a serious game supporting environmental health education and contributory approaches, questagame was launched in 2014 in canberra through a successful crowdfunding campaign. the game has players around the world mapping biodiversity sightings and sending photographs through the questagame mobile app for identification. the data feeds are downloaded for research, of which 1.6 million verifications have been identified at the time of this article [59]. health promotion contributory models of approach have largely been applied to public participation in health promotion and public health research in several large-scale campaigns in australia. for example, the anti-cancer council of the australian state of victoria has been running sun protection citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi programmes for several decades: slip! slop! slap! from 1980 to 1988 and sunsmart from 1988 to the present [60]. sunday morning is an australian social media health promotion movement that asks participants to publicly set a personal goal to stop drinking or reduce their alcohol consumption for a set period of time, and to record their reflections and progress on blogs and social networks [61]. the hello sunday platform was created in 2010 and, thus far, participants have shared over 2 million stories according to the website [62]. foodswitch is a mobile phone app that allows users to access easy-to-understand information about the nutritional characteristics of packaged foods and, where available, to suggest healthier alternative products [63]. a particular innovation in the app was the incorporation of a crowdsourcing function whereby users are able to contribute information on missing products. if a barcode is scanned but the corresponding universal product code (upc) is not identified in the database, then the user is prompted to photograph the front of the package, the nutrition information panel (nip), and the ingredients list. the data are uploaded to the data management center site, and the information is added to a national database. periodic updates to the database are then made to ensure that the app is supported by complete and up to date product information [64]. epidemiology and exposure science australian researchers have also employed citizen science contributory models to engage the public in specific areas of health condition enquiry. the big sleep survey undertaken in 2010 solicited the contribution of participants who monitored their sleeping habits for one week for the woolcock institute and sydney university [65]. more than 12,000 participants reported on their personal sleep habits in the questionnaire, while over 3,500 people completed the week-long sleep diaries recording the time they went to bed, fell asleep and woke up, for example [66]. dustsafe is a citizen-science initiative based in the department of environmental sciences at macquarie university in sydney a local chapter of the global program: 360 dust analysis [67], which encompasses research groups in australia, asia, the united kingdom, and the u.s. together, these programs are focused on characterising household dust in an effort to understand the potential health exposure hazards residing in that dust. greater urbanisation means people are spending up to 90% of their time indoors. consequently, environmental health risks are dominated by fine dust particles from indoor air aerosols and harmful agents that can penetrate deep into lungs and migrate into the blood stream. knowledge gaps are addressed by engaging the public to submit vacuum dust samples for chemical and biological analysis [68]. an example of a participatory sensing initiative, the citizen science project is a collaboration between rmit university in melbourne and the university of new south wales in sydney begun in 2018 [69]. the project aims to involve the public in measuring urban heat island effects and local climate change. public participants perform outdoor microclimatic measurements of temperature, humidity, wind speed, among other measures, using portable handheld sensing devices provided by the project on a selected day at a selected location. health data systems the garvan institute of medical research in sydney and the vodafone foundation have recently initiated a computing platform that uses the collective processing capacity of smartphones to citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi analyse numbers and compare genetic profiles of tumours through the dreamlab mobile app [70]. the public can contribute their mobile phone’s processing power when a phone is fully charged or charging overnight, for instance, whilst the dreamlab app analyses research data for breast, ovarian, prostate and pancreatic cancers. an example of a collaborative platform, crowdsourcing critical appraisal of research evidence or crowdcare is a freely available online tool developed by university of melbourne researchers that aims to teach critical appraisal and facilitate the sharing of appraisals amongst a global community of clinicians [71]. after completing compulsory training modules, individuals can contribute to, and benefit from, an evolving collection of appraised research evidence generated from an interdisciplinary group, committed to practicing evidence-based practice (ebp). this platform is unique in that it goes beyond the use of crowdsourced judgments by article type (e.g. rcts), as in cochranecrowd to an in-depth assessment of the methodological rigour of the articles [72]. on the level of individual self-tracking, which can be a means of contributing personal physiological data to larger research studies, there are numerous communities using self-tracking tools and technologies, many of whom identify with the quantified self (qs) movement. qs is defined as “embodying self-knowledge through self-tracking” [73], and one of the early quantified-self group setups outside of the u.s. was based in sydney, australia [46]. strava, the international social fitness network, has an australian membership of self-quantifiers who measure physical performance, primarily tracking cycling and running activities using gps data [74]. australian researchers have partnered with strava members in a range of studies, such as understanding the personal data practices of commuting cyclists, for example [75]. challenges and limitations public participation in health research in australia potentially faces several shared challenges to those experienced world-wide in the citizen science community. the lack of standard definitional boundaries of what constitutes digitally-enabled public participation in health research relates to a diversity of approaches, e.g. citizen science, community-based participatory research (cbpr), action research, patient and public involvement (ppi), and crowdsourcing, among other approaches [15,23,76]. critically, within this context, there is a clear gap in readily identifying tools and platforms, particularly those which are supporting digitally-enabled participation of the public, their efficacy and support of different levels of participation. for instance, tools supporting local participatory engagement, e.g. cbpr, may differ from those in use by self-quantifying participants or by a broader public in larger crowdsourced projects, for instance. generally, in public participation in health research, the more closely-associated a project is with the participant (e.g. in the home or the individual person), the greater the potential for legal, ethical, privacy, biosafety and data management and ownership complications to be raised [77,78]. it is, therefore, necessary to consider what shared standards, methodologies and practices might be applicable [2,79]. a related challenge is that stronger public involvement in health research requires improved understanding of research processes [1]. for instance, public involvement in research data citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi processes and ensuring data quality are pervasive issues; primarily due to the fact that a non-expert public is generally considered to be untrained in research data management or research integrity, or may be prone to systematic errors which can impact data quality [80,81]. data quality can also be highly context dependent (i.e. “fitness for use”) [81-83]. a higher level of quality assurance is often associated with the use of crowdsourcing in which many people carry out the same work or task, such as contributing to peer review [39,84], or replication of an analysis, such as image identification [27]. such an approach is desirable across the sciences for validation, accuracy, and in reducing bias. the critical research appraisal tool crowdcare, for instance, has shown that novices can be trained to appraise the rigor of published systematic reviews and, on average, achieve a high degree of accuracy relative to the experts [72]. additionally, there are identified gaps in the literature on reporting methods and the extent of public involvement in clinical trials which constitute a critical share of health and biomedical research design. a study of public research involvement in online trials concerning health selfmanagement, for example, found that detailed reporting of such involvement was hindered by role confusion between research volunteers and trial participants [22]. other related study findings contribute to the literature by documenting researchers’ perspectives and experiences about sharing results with research participants. one such study surveyed health researchers in which the majority of respondents indicated that health research results should always be shared with participants [85]; although the described barriers to results sharing and various reported reasons not to share results suggest difficulties with a “one-size-fits-all” approach to improving results sharing. legal jurisdictional areas may differ in terms of the extent of sharing of results with participants. in the u.s., for instance, it is not normative for health research ethics review boards to encourage health researchers to share aggregate study findings in contrast to practices in australia, for example [85]. a poll conducted by research australia in 2019 indicated that a majority of australians were willing to share their personal health information for research purposes, in order to advance health and medical research (78%), support healthcare providers in improving patient care (68%), and to assist public health officials in tracking diseases, disabilities and their causes (61%) [86]. however, the proportion of consumers in support of sharing health data with government organisations can be significantly lower [86,87]. indigenous communities are particularly concerned with issues pertaining to handling, treatment, and ownership of tissue as well as knowledge gained from specimen analysis. this stems from a strong and integrated sense of cultural connection to ancestors and traditional lands and indigenous communities view biological specimens as inseparable from these connections [88]. conclusion australia has long-standing traditions in aspects of citizen science and participatory approaches to scientific enquiry, as can be gleaned from major projects and historical activities outlined in the present paper. however, there are gaps in our understanding of the extent of public participation in health research as part of this paradigm shift, particularly as it may relate to digitally-enabled processes. progress in this area depends on identifying partnerships across the shared challenges, citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi and extending work on how established citizen science models may help support the quality of and the translation of public engagement in health research in australia. acknowledgements ann borda received an expert visit grant in 2019 as part of the epic project funded under the eu horizon 2020 programme (ict) to explore advancing approaches to citizen science methods, platforms and capabilities in healthcare and medical research. references 1. todd al, nutbeam d. 2018. involving consumers in health research: what do consumers say? public health res pract. 28(2), e2821813. pubmed https://doi.org/10.17061/phrp2821813 2. wiggins a, wilbanks j. 2019. the rise of citizen science in health and biomedical research. am j bioeth. 19(8), 3-14. pubmed https://doi.org/10.1080/15265161.2019.1619859 3. national health and medical research council. 2016. statement on consumer and community involvement in health and medical research. canberra [act]: nhmrc. [cited 31 october 2019]; available at: https://www.nhmrc.gov.au/about-us/publications/statementconsumer-and-community-involvement-health-and-medical-research 4. australian health research alliance. 2018. consumer and community involvement in health and medical research: an australia-wide audit. available from: https://www.slhd.nsw.gov.au/sydneyhealthpartners/pdf/ahra_cci_final_report.pdf 5. irwin a. citizen science: a study of people, expertise and sustainable development. london: routledge; 1995. 6. bonney r, et al. 2009. citizen science: a developing tool for expanding science knowledge and scientific literacy. bioscience. 59(11), 977-84. https://doi.org/10.1525/bio.2009.59.11.9 7. kullenberg c, kasperowski d. 2016. what is citizen science? – a scientometric metaanalysis. plos one. 11(1), e0147152. doi:https://doi.org/10.1371/journal.pone.0147152. pubmed 8. shirk jl, ballard hl, wilderman cc, phillips t, wiggins a, et al. 2012. public participation in scientific research: a framework for deliberate design. ecol soc. 17(2), 29. https://doi.org/10.5751/es-04705-170229 9. wiggins a, crowston k. 2014. surveying the citizen science landscape. first monday. 20(1). https://doi.org/10.5210/fm.v20i1.5520 10. silvertown j. 2009. a new dawn for citizen science. trends ecol evol. 24(9), 467-71. pubmed https://doi.org/10.1016/j.tree.2009.03.017 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29925089&dopt=abstract https://doi.org/10.17061/phrp2821813 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=31339831&dopt=abstract https://doi.org/10.1080/15265161.2019.1619859 https://doi.org/10.1525/bio.2009.59.11.9 https://doi.org/10.1371/journal.pone.0147152 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26766577&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26766577&dopt=abstract https://doi.org/10.5751/es-04705-170229 https://doi.org/10.5210/fm.v20i1.5520 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19586682&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19586682&dopt=abstract https://doi.org/10.1016/j.tree.2009.03.017 citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi 11. olsen p. collecting ladies: ferdinand von mueller and women botanical artists. canberra[ act]: national library australia; 2013. 12. prober sm, o’connor mh, walsh fj. 2011. australian aboriginal peoples’ seasonal knowledge: a potential basis for shared understanding in environmental management. ecol soc. 16(2), 12. http://www.ecologyandsociety.org/vol16/iss2/art12/. https://doi.org/10.5751/es-04023-160212 13. hamacher dw. 2018. observations of red-giant variable stars by aboriginal australians. aust j anthropol. 29, 89-107. https://doi.org/10.1111/taja.12257 14. leach m, fairhead j. 2002. manners of contestation: “citizen science” and “indigenous knowledge” in west africa and the caribbean. int soc sci j. 54, 299-311. https://doi.org/10.1111/1468-2451.00383 15. storksdieck m, shirk jl, cappadonna jl, domroese m, göbel c, et al. 2016. associations for citizen science: regional knowledge, global collaboration. citizen science: theory and practice. 1(2),1–10. available at: https://theoryandpractice.citizenscienceassociation.org/articles/10.5334/cstp.55/ 16. pecl g, gillies c, sbrocchi c, roetman p. 2015. building australia through citizen science. office of the chief scientist. canberra (act). available from: http://www.chiefscientist.gov.au/wp-content/uploads/citizen-science-op_web.pdf 17. european citizen science association. ten principles of citizen science. available at: https://ecsa.citizen-science.net/engage-us/10-principles-citizen-science 18. belbin l, williams kj. 2016. towards a national bio-environmental data facility: experiences from the atlas of living australia. int j geogr inf sci. 30(1), 108-25. https://doi.org/10.1080/13658816.2015.1077962 19. acsa. australian citizen science project finder. available at: biocollect.ala.org.au/acsa 20. australian government. the department of industry, innovation and science. citizen science grants. 2018. available at: https://www.business.gov.au/assistance/inspiringaustralia-science-engagement/citizen-science-grants 21. eitzel mv, cappadonna jl, santos-lang c, duerr re, virapongse a, et al. 2017. citizen science terminology matters: exploring key terms. citizen science: theory and practice. 2(1), 1. available at: https://theoryandpractice.citizenscienceassociation.org/articles/10.5334/cstp.96/ 22. nunn js, tiller j, fransquet p, lacaze p. 2019. public involvement in global genomics research: a scoping review. front public health. 7, 79. pubmed https://doi.org/10.3389/fpubh.2019.00079 https://doi.org/10.5751/es-04023-160212 https://doi.org/10.1111/taja.12257 https://doi.org/10.1111/1468-2451.00383 https://doi.org/10.1080/13658816.2015.1077962 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=31024880&dopt=abstract https://doi.org/10.3389/fpubh.2019.00079 citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi 23. rowbotham s, mckinnon m, leach j, lamberts r, hawe p. 2019. does citizen science have the capacity to transform population health science? crit public health. 21, 118-28. https://doi.org/10.1080/09581596.2017.1395393 24. wiggins a, wilbanks j. 2019. the rise of citizen science in health and biomedical research. am j bioeth. 19(8), 3-14. pubmed https://doi.org/10.1080/15265161.2019.1619859 25. créquit p, mansouri g, benchoufi m, vivot a, ravaud p. 2018. mapping of crowdsourcing in health: systematic review. j med internet res. 20(5). pubmed 26. crocker jc, boylan a-m, bostock j, locock l. 2016. is it worth it? patient and public views on the impact of their involvement in health research and its assessment: a uk-based qualitative interview study. health expect. 20, 519-28. pubmed https://doi.org/10.1111/hex.12479 27. wazny k. 2018. applications of crowdsourcing in health: an overview. j glob health. 8(1), 010502. pubmed https://doi.org/10.7189/jogh.08.010502 28. haklay m. 2013. citizen science and volunteered geographic information – overview and typology of participation. in: sui, dz, elwood, s, and mf goodchild (eds.). crowdsourcing geographic knowledge. berlin: springer, 105-122. 29. english pb, richardson mj, garzon-galvis c. 2018. from crowdsourcing to extreme citizen science: participatory research for environmental health. annu rev public health. 39, 335-50. pubmed https://doi.org/10.1146/annurev-publhealth-040617-013702 30. kelty c, panofsky a, currie m, crooks r, erickson s, et al. 2015. seven dimensions of contemporary participation disentangled. j assoc inf sci technol. 66(3), 474-88. https://doi.org/10.1002/asi.23202 31. israel ba, schulz aj, parker ea, becker ab. 1998. review of community-based research: assessing partnership approaches to improve public health. annu rev public health. 19, 173-202. pubmed https://doi.org/10.1146/annurev.publhealth.19.1.173 32. hicks s, duran b, wallerstein n, avila m, et al. 2012. evaluating community-based participatory research to improve community-partnered science and community health. prog community health partnersh. 6(3), 289-99. pubmed https://doi.org/10.1353/cpr.2012.0049 33. minkler m. 2014. enhancing data quality, relevance, and use through community-based participatory research. in: federal reserve bank of san francisco and urban institute(eds). what counts: harnessing data for america’s communities. san francisco & washington, dc., 244-259. available at: http://www.whatcountsforamerica.org/ 34. den broeder l. 2017. citizen science for health in all policies. engaging communities in knowledge development. phd thesis, vu university amsterdam, the netherlands. available at: http://library.wur.nl/webquery/wurpubs/529909 https://doi.org/10.1080/09581596.2017.1395393 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=31339831&dopt=abstract https://doi.org/10.1080/15265161.2019.1619859 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29764795&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27338242&dopt=abstract https://doi.org/10.1111/hex.12479 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29564087&dopt=abstract https://doi.org/10.7189/jogh.08.010502 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29608871&dopt=abstract https://doi.org/10.1146/annurev-publhealth-040617-013702 https://doi.org/10.1002/asi.23202 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=9611617&dopt=abstract https://doi.org/10.1146/annurev.publhealth.19.1.173 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22982842&dopt=abstract https://doi.org/10.1353/cpr.2012.0049 citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi 35. rowbotham s, mckinnon m, leach j, lamberts r, hawe p. 2019. does citizen science have the capacity to transform population health science? crit public health. 29(1), 118-28. https://doi.org/10.1080/09581596.2017.1395393 36. dawson r, bynghall s. 2012. getting results from crowds: the definitive guide to using crowdsourcing to grow your business. san francisco: advanced human technologies. 37. swan m. 2012. health 2050: the realization of personalized medicine through crowdsourcing, the quantified self, and the participatory biocitizen. j pers med. 2(3), 93118. pubmed https://doi.org/10.3390/jpm2030093 38. bashthebug [internet]. oxford university [cited 2019 october 1]. available at: http://bashthebug.net/ 39. thomas j, noel-storr a, marshall i, wallace b, mcdonald s, et al. 2017. living systematic reviews 2: combining human and machine effort. j clin epidemiol. 91(nov), 31-37. pubmed https://doi.org/10.1016/j.jclinepi.2017.08.011 40. ozcan a. 2014. educational games for malaria diagnosis. sci transl med. 6, 233ed9. pubmed https://doi.org/10.1126/scitranslmed.3009172 41. curtis v. 2014. online citizen science games: opportunities for the biological sciences. appl transl genomics. 3(4), 90-94. pubmed https://doi.org/10.1016/j.atg.2014.07.001 42. johnson d, deterding s, kuhn k, staneva a, stoyanov s, et al. 2016. gamification for health and wellbeing: a systematic review of the literature. internet interv. 6, 89-106. pubmed https://doi.org/10.1016/j.invent.2016.10.002 43. pauwels e, denton s. 2018. the rise of the bio-citizen. 1st ed. washington, d.c.: the wilson centre. available from: https://www.wilsoncenter.org/sites/default/files/rise_of_biocitizenfinal.pdf 44. rabinow p. 1996. artificiality and enlightenment: from sociobiology to biosociality. in: essays on the anthropology of reason. princeton university press. 45. bietz m, patrick k, bloss c. 2019. data donation as a model for citizen science health research. citizen science: theory and practice. 4(1), 6, 1–11. available at: https://theoryandpractice.citizenscienceassociation.org/articles/10.5334/cstp.178/ 46. almalki m, gray k, martin-sanchez f. 2015. the use of self-quantification systems for personal health information: big data management activities and prospects. health inf sci syst. 3(suppl 1), s1. pubmed https://doi.org/10.1186/2047-2501-3-s1-s1 47. workman ta. engaging patients in information sharing and data collection: the role of patient-powered registries and research networks. ahrq community forum white paper. ahrq publication no. 13-ehc124-ef. rockville, md: agency for healthcare https://doi.org/10.1080/09581596.2017.1395393 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25562203&dopt=abstract https://doi.org/10.3390/jpm2030093 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28912003&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28912003&dopt=abstract https://doi.org/10.1016/j.jclinepi.2017.08.011 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=24760185&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=24760185&dopt=abstract https://doi.org/10.1126/scitranslmed.3009172 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27294021&dopt=abstract https://doi.org/10.1016/j.atg.2014.07.001 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30135818&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30135818&dopt=abstract https://doi.org/10.1016/j.invent.2016.10.002 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26019809&dopt=abstract https://doi.org/10.1186/2047-2501-3-s1-s1 citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi research and quality; september 2013. available at: https://effectivehealthcare.ahrq.gov/products/stakeholders-engagement-others/white-paper 48. patientslikeme [internet]. patientslikeme inc. [cited 2019 october 1]. available at: patientslikeme.com 49. iconquerms [internet]. iconquerms.org [cited 2019 october 1]. available at: www.iconquerms.org 50. mpower initiative [internet]. sagebionetworks.org [cited 2019 october 1]. available at: parkinsonmpower.org/ 51. all of us [internet]. u.s. department of health & human services. national institutes of health [cited 2019 october 1]. available at: https://allofus.nih.gov/ 52. tallachini m, boucher p, nascimento s. 2014. emerging ict for citizens’ veillance. european commission jcr science and policy reports. 53. involve [internet]. uk department of health and social care. national institute for health research [cited 2019 october 1]. available at: https://www.invo.org.uk/ 54. consumer and community health research [internet]. the university of western australia [cited 2019 october 1]. available at: www.involvingpeopleinresearch.org.au 55. australian indigenous doctors’ association and centre for health equity training raeu. 2010. health impact assessment of the northern territory emergency response. canberra: australian indigenous doctors’ association. available at: https://hiaconnect.edu.au/reports/health-impact-assessment-of-the-northern-territoryemergency-response/ 56. den broeder l, devilee j, van oers h, schuit aj, wagemakers a. 2016. citizen science for public health. health promot int. 33(3), 505-14. pubmed 57. the tracks hub [internet]. indigenous desert alliance and atlas of living australia (cited 2019 october 1). available at: https://biocollect.ala.org.au/trackshub/ 58. eye on water [internet]. eyeonwater.org and csiro [cited 2019 october 1]. available at: www.eyeonwater.org/apps/eyeonwater-australia 59. questagame [internet]. questagame.com [cited 2019 october 1]. available at: https://questagame.com/ 60. sunsmart [internet]. sun smart victoria and cancer council victoria, melbourne vic australia [cited 2019 october 1]. available at: www.sunsmart.com.au/ 61. hello sunday morning [internet]. hellosundaymorning.org [cited 2019 october 1]. available at: www.hellosundaymorning.org https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28011657&dopt=abstract citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi 62. tait r, kirkman jjl, schaub mpa. 2018. participatory health promotion mobile app addressing alcohol use problems (the daybreak program): protocol for a randomized controlled trial. jmir res protoc. 7(5), e148. pubmed https://doi.org/10.2196/resprot.9982 63. foodswitch [internet]. the george institute for global health, sydney, nsw australia [cited 2019 october 1]. available at: http://www.foodswitch.com.au/ 64. dunford e, trevena h, goodsell c, ng kh, webster j, et al. 2014. foodswitch: a mobile phone app to enable consumers to make healthier food choices and crowdsourcing of national food composition data. jmir mhealth uhealth. 2(3), e37. pubmed https://doi.org/10.2196/mhealth.3230 65. big sleep survey [internet]. centre for integrated research and understanding of sleep, university of sydney, nsw australia [cited 2019 october 1]. available at: www.cirus.org.au/get-involved/sleep-survey/index.php 66. miller cb, gordon cj, toubia l, bartlett dj, grunstein r, et al. 2015. agreement between simple questions about sleep duration and sleep diaries in a large online survey. sleep health. 1(2), 133-37. pubmed https://doi.org/10.1016/j.sleh.2015.02.007 67. 360 dust analysis [internet]. macquarie university, sydney nsw australia [cited 2019 october 1]. available at: www.360dustanalysis.com/ 68. filippelli gm, taylor mp. 2018. addressing pollution-related global environmental health burdens. geohealth. 2, 2-5. https://doi.org/10.1002/2017gh000119 69. citizen science project [internet]. rmit university, melbourne, vic australia [cited 2019 october 1]. available at: citizenscienceproject.org.au 70. retka-tidd m. pancreatic cancer: taking aim at the ‘silent killer’ online and overnight [internet]. garvan institute of medical research and vodafone australia [cited 2019 october 1]. available at: https://www.vodafone.com.au/red-wire/dreamlab-pancreaticcancer 71. crowdcare [internet]. the university of melbourne vic australia [cited 2019 october 1]. available at: crowdcare.unimelb.edu.au 72. pianta m, makrai e, verspoor km, cohn t, downie l. 2018. crowdsourcing critical appraisal of research evidence (crowdcare) was found to be a valid approach to assessing clinical research quality. j clin epidemiol. 104, 8-14. pubmed https://doi.org/10.1016/j.jclinepi.2018.07.015 73. quantified self institute [internet]. hanze university of applied sciences, groningen, the netherlands [cited 2019 october 1]. available at: https://qsinstitute.com 74. strava [internet]. strava.com [cited 2019 october 1]. available at: www.strava.com https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29853435&dopt=abstract https://doi.org/10.2196/resprot.9982 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25147135&dopt=abstract https://doi.org/10.2196/mhealth.3230 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29073377&dopt=abstract https://doi.org/10.1016/j.sleh.2015.02.007 https://doi.org/10.1002/2017gh000119 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30075189&dopt=abstract https://doi.org/10.1016/j.jclinepi.2018.07.015 citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi 75. lupton d, pink s, heyes labond c. 2018. personal data contexts, data sense, and selftracking cycling. int j commun. 12, 647-65. 76. synnot a, bragge p, lowe d, et al. 2018. research priorities in health communication and participation: international survey of consumers and other stakeholders. bmj open. 8(5), e019481. https://bmjopen-bmj-com.ezp.lib.unimelb.edu.au/content/8/5/e019481. pubmed https://doi.org/10.1136/bmjopen-2017-019481 77. fiske a, del savio l, prainsack b, buyx a. 2018. conceptual and ethical considerations for citizen science in biomedicine. in: heyen n, dickel s, brüninghaus a(eds). personal health science. wiesbaden: springer, 195-217. 78. resnik db. 2019. citizen scientists as human subjects: ethical issues. citizen science: theory and practice. 4(1), 11. available at: https://theoryandpractice.citizenscienceassociation.org/articles/10.5334/cstp.150/ 79. heigl f, kieslinger b, paul kt, uhlik j, dörler d. 2019. opinion: toward an international definition of citizen science. proc natl acad sci usa. 116(17), 8089-92. doi:https://doi.org/10.1073/pnas.1903393116. pubmed 80. riesch h, potter c. 2014. citizen science as seen by scientists: methodological, epistemological and ethical dimensions. public underst sci. 23(1), 107-20. pubmed https://doi.org/10.1177/0963662513497324 81. gabrys j, pritchard h, barratt b. 2016. just good enough data: figuring data citizenships through air pollution sensing and data stories. big data soc. 3(2), 1-14. https://doi.org/10.1177/2053951716679677 82. kelling s, fink d, la sorte fa, johnston a, bruns ne, et al. 2015. taking a ‘big data’ approach to data quality in a citizen science project. ambio. 44(s4), 601-11. pubmed https://doi.org/10.1007/s13280-015-0710-4 83. kosmala m, wiggins a, swanson a, simmons b. 2016. assessing data quality in citizen science. front ecol environ. 14(10), 551-60. https://doi.org/10.1002/fee.1436 84. strang l, simmons rk. 2018. crowdsourcing-for-systematic-reviews. cambridge: the healthcare improvement studies institute. available from: https://www.thisinstitute.cam.ac.uk/wp-content/uploads/2018/06/this-institute-citizenscience-crowdsourcing-for-systematic-reviews-978-1-9996539-1-0.pdf 85. long cr, purvis rs, flood-grady e, kimminau ks, rhyne rl, et al. 2019. health researchers’ experiences, perceptions and barriers related to sharing study results with participants. health res policy syst. 17(25). pubmed 86. research australia. 2019. australia speaks! research australia opinion polling for health and medical research. available at: https://researchaustralia.org/reports/public-opinionpolling-2/ https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29739780&dopt=abstract https://doi.org/10.1136/bmjopen-2017-019481 https://doi.org/10.1073/pnas.1903393116 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=31015357&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23982281&dopt=abstract https://doi.org/10.1177/0963662513497324 https://doi.org/10.1177/2053951716679677 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26508347&dopt=abstract https://doi.org/10.1007/s13280-015-0710-4 https://doi.org/10.1002/fee.1436 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30832733&dopt=abstract citizen science models in health research: an australian commentary online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 11(3):e23, 2019 ojphi 87. srinivasan u, rao s, ramachandan d, jonas d. 2016. flying blind: australian consumers and digital health. australian health data series. vol. 1. sydney: capital markets cooperative research centre. available from: https://flyingblind.cmcrc.com/files/files/flying-blind--australian-consumers-and-digitalhealth.pdf 88. aramoana j, koea j and on behalf of the commnets collaboration. 2019. an integrative review of the barriers to indigenous peoples participation. journal of global oncology. 5; jgo.18.00156. leveraging informatics and technology to support public health response: framework and illustrations using covid-19 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi leveraging informatics and technology to support public health response: framework and illustrations using covid-19 jane l. snowdon phd1*, william kassler md mph1, hema karunakaram mph1, brian e. dixon mpa phd2,3, kyu rhee md mpp1 1ibm watson health, cambridge, ma, usa 2center for biomedical informatics, regenstrief institute, indianapolis, in, usa 3department of epidemiology, richard m. fairbanks school of public health, indiana university, indianapolis, in, usa abstract objective: to develop a conceptual model and novel, comprehensive framework that encompass the myriad ways informatics and technology can support public health response to a pandemic. method: the conceptual model and framework categorize informatics solutions that could be used by stakeholders (e.g., government, academic institutions, healthcare providers and payers, life science companies, employers, citizens) to address public health challenges across the prepare, respond, and recover phases of a pandemic, building on existing models for public health operations and response. results: mapping existing solutions, technology assets, and ideas to the framework helped identify public health informatics solution requirements and gaps in responding to covid-19 in areas such as applied science, epidemiology, communications, and business continuity. two examples of technologies used in covid-19 illustrate novel applications of informatics encompassed by the framework. first, we examine a hub from the weather channel, which provides covid-19 data via interactive maps, trend graphs, and details on case data to individuals and businesses. second, we examine ibm watson assistant for citizens, an ai-powered virtual agent implemented by healthcare providers and payers, government agencies, and employers to provide information about covid-19 via digital and telephone-based interaction. discussion: early results from these novel informatics solutions have been positive, showing high levels of engagement and added value across stakeholders. conclusion: the framework supports development, application, and evaluation of informatics approaches and technologies in support of public health preparedness, response, and recovery during a pandemic. effective solutions are critical to success in recovery from covid-19 and future pandemics. keywords: coronavirus, pandemics, public health informatics, clinical informatics, artificial intelligence, information technology correspondence: snowdonj@us.ibm.com* doi: 10.5210/ojphi.v13i1.11072 mailto:snowdonj@us.ibm.com* leveraging informatics and technology to support public health response: framework and illustrations using covid-19 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi introduction the united states has faced numerous pandemics including the hiv/aids pandemic; the zika, mers, and ebola outbreaks; and the current novel coronavirus disease 2019 (covid-19) pandemic. each experience has revealed opportunities for improvement by highlighting unmet data and information needs [1] among clinicians, public health agencies, policymakers, and researchers during the three stages of a disease outbreak: preparedness, response, and recovery. some of these prior lessons are summarized in table 1, adapted from an article by paules et al. [2]. table 1. optimal response to emerging infectious disease outbreaks: lessons learned global surveillance to detect outbreaks easily transparency and communication in response to outbreaks incorporation of infrastructure and capacity building domestically and internationally in outbreak responses conduct of basic and clinical research associated with outbreaks in a coordinated and collaborative manner involvement of the afflicted communities in policy decisions pursuit and perfection of adaptable platform technologies for vaccines, diagnostics, and therapeutics importance of flexible funding mechanisms benefits of data standards and standardization to facilitate the interoperability of solutions critical need for investing in skills, training, and skills in science, technology, engineering, and mathematics (stem) to grow national competencies in just 6 months, covid-19 spread rapidly from the first reported cases of the sars-cov-2 virus in wuhan, china in december 2019 across the globe causing 9,843,073 cases and 495,760 deaths in over 185 countries as of june 28, 2020 [3,4]. unlike prior pandemics, covid-19 response and recovery will rely more heavily on informatics and technology given their extensive diffusion into business, health care and everyday life. already the us has leveraged cloud computing, video conferencing, collaboration tools, and digital security solutions to support remote working by employees, as well as artificial intelligence (ai) to diagnose covid symptoms [1,5-7]. copyright ©2021 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. leveraging informatics and technology to support public health response: framework and illustrations using covid-19 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi prior lessons and frameworks for public health response do not focus on the roles of informatics or technology, and they tend to be heavily focused on vaccine and therapeutic development [2]. the informatics community needs a method for framing covid-19 response and lessons learned to highlight the diverse ways that computing, algorithms, and informaticians contribute to addressing the pandemic. such a framework could be used by researchers, policymakers, and organizational leaders to measure response activities to covid-19, monitor recovery, and help to prepare and plan for future health threats. the objective of this paper is to describe and illustrate a novel, comprehensive framework that encompasses the myriad ways informatics and technology can support public health response to a pandemic like covid-19. in this context, public health response spans government, industry, academia, and citizens, and is not solely limited to government. the pandemic framework supports and expands the broader concept of public health 3.0 [8,9]. two case examples showing early outcomes of how informatics and technology are supporting the u.s. response to covid-19 are given. consideration of health informatics and technology from an outbreak’s local onset to a global pandemic relies on trusted sources of public health protocols, plans, and data from governmental organizations such as the world health organization (who), centers for disease control and prevention (cdc), centers for medicare and medicaid services (cms), and from the private sector such as the weather company (twc). having good data is critical for developing predictions, assessing risks, allocating resources, and measuring the effectiveness of interventions, such as wearing masks and social distancing. incorrect or incomplete data may cause harm by omitting important socioeconomic factors, obscuring trends or correlations, and may lead to illinformed or incorrect actions by decision-makers. methods the covid-19 pandemic highlights the complexity and challenges in responding to a significant, widespread man-made or natural disaster including emerging infectious diseases. saving lives, maintaining critical infrastructure, and restoring essential services require coordinated response across various governmental and private sector organizations to mobilize resources and capabilities to provide support and services [10]. these tasks involve a diverse set of functions that are data-rich and heavily quantitative. informatics and technology can play significant supportive roles before, during, and after the public health emergency. figure 1 illustrates a conceptual model of public health preparedness for major health threats. the model is adapted from the traditional public health stages of disease outbreak [11] and expanded to incorporate stakeholders and sectors beyond governmental public health. note that there is overlap among the set of stakeholders who are not mutually exclusive. leveraging informatics and technology to support public health response: framework and illustrations using covid-19 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi figure 1. a conceptual model of public health preparedness encompassing the phases, economic sectors, and cross-sector organizations that engage in preparing, responding, and recovering to major health threats. prepare preparing for a crisis requires an understanding of the potential challenge, having the foundation in place to assure continuity of operations, developing the plans and policies to enable a rapid response, and building the infrastructure to support those in need. taking steps to reduce vulnerability to disaster before the emergency is critical for success. unlike some natural disasters that occur regularly and with predictable periodicity (e.g., hurricanes, fires), pandemics are spontaneous and unpredictable. because infectious disease outbreaks can rapidly spread across the globe, having plans, policies and resources in place allows government officials to take early steps to limit disease from spreading. while it is impossible to plan for every contingency, building capacity to respond can significantly mitigate the impact on a community. respond responding is the period when stakeholders implement plans, translate science into practice, and course-correct based on new data to improve practices. as exhibited during covid-19, the impact of a rapid and widespread, novel infectious disease can cause massive disruption across many sectors of the economy. thus, pandemic response is a coordinated effort across multiple sectors. leveraging informatics and technology to support public health response: framework and illustrations using covid-19 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi in the area of basic science, response is mobilizing to characterize the etiologic agent and its genetics, and to develop diagnostic tests, drugs and vaccines. the life sciences industry plays a critical role in executing the applied science and manufacturing needed to develop vaccines, tests and treatments, and to successfully bring them to market. in the healthcare sector, payers, health plans and providers work in concert to assure those in need get services in the face of an unprecedented surge in demand resulting from local outbreaks. government has a unique role in helping to monitor the situation, coordinate across numerous public and private organizations, mobilize supportive assets and provide financial resources. epidemiology plays a key role in understanding patterns of transmission, describing the clinical course, individual and population risk factors, quantifying the burden of illness, and creating mathematical models to predict demographic and geographic spread of disease. public health departments focus on interventions to mitigate the spread, including case finding, contact tracing, quarantine, and isolation. communication and dissemination of information is critical to response, particularly in the face of rapidly evolving events. government is the natural leader for overall coordination and communication efforts. government also plays a key role in translation of newly emerging evidence into best practices and policy. disasters often stress the economy and, as in the case of covid-19, expose structural weaknesses revealing significant gaps in organizational capacity, staff and resources. private industries across economic sectors work to assure continuity of operations, repairing broken supply chains and creating and adapting to new ways of working to mitigate transmission. recover pandemic recovery takes time. even before the pandemic recedes, many recovery actions can begin, starting with measured re-opening of business, schools and other public spaces, as well as providing short-term relief for people most impacted. intermediate-term recovery involves dealing with the secondary impact. as the epidemic curve wanes and healthcare surges decline, additional impact from secondary surges will be felt. new curves will arise resulting from the increased demand following disruptions in routine healthcare. delayed primary and secondary prevention will result in surges of pent up demand for elective surgical procedures, in routine care for chronic disease, and in increased admissions for ambulatory sensitive and prevention sensitive conditions (e.g. increased infectious disease outbreaks for vaccine preventable diseases, increased admissions for poorly controlled diabetes and asthma, and more presentation of severe and later-stage illness such as cancer). given the stress, anxiety, social isolation, economic hardships, and collective trauma, another surge in demand for mental health services is also expected. long-term recovery means building individual and community resiliency. this involves an afteraction review of the responses carried out during the crisis, a formal evaluation of what interventions did and did not work in order to understand best practices and lessons learned, and feedback of insights into the preparation stage to improve future emergency responses. leveraging informatics and technology to support public health response: framework and illustrations using covid-19 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi a framework for pandemic preparedness, response, and recovery building upon this conceptual model, we developed a framework for characterizing informatics and technology support of the diverse tasks involved in public health preparedness, response and recovery as depicted in figure 2. each category consists of multiple informatics and technology solutions that can be leveraged during one or more phases of a significant health threat. furthermore, each category is primarily driven by a specific stakeholder group. it should be noted that multiple stakeholders may play a role in funding, implementing, or using the informatics and technology solutions that correspond to a given category. figure 2. a framework for leveraging informatics and technology to support public health preparedness, response, and recovery. benchside benchside solutions focus on applied science and span the “prepare” and “respond” phases of the pandemic. life sciences companies who have invested in informatics solutions for drug and vaccine development can quickly ramp up to address a pandemic. automated digital tools, including ai, can support drug development with clinical trial study protocol design and development, and electronic data capture and management, to shorten the timeline to release new drugs and vaccines to the market [12-15]. bedside bedside solutions support clinical care and decision-making for provider organizations in the “respond” phase. these solutions may help automate triage of patients seeking care based on symptoms or may reallocate clinical staff across an organization based on demand for services. leveraging informatics and technology to support public health response: framework and illustrations using covid-19 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi reeves et al. [16] describe the design and rapid creation of a covid-19 operational dashboard by a multidisciplinary team of providers and administrators. the dashboard provided real-time data and analytics on the number of patients tested, test results, intensive care unit bed availability, ventilator unit availability, and ambulatory visit volume. disease investigation, modeling and monitoring epidemiologists use a variety of tools that span the “respond” and “recover” phases of the pandemic to model disease outbreak and monitor infectious disease cases. surveillance helps provide situational awareness and enhances early detection and response. public and private scientific organizations may use these tools to map the spread of disease, track infection rates and outcomes across populations, and predict where more resources need to be allocated. as the understanding of the disease evolves, solutions can also assist contact tracing, quarantine and isolation efforts to contain the disease. one example is spatiotemporal epidemiologic modeler (stem), an open source software project supported by the eclipse foundation, which is used by a global community of researchers and public health officials for disease modeling and tracking [17]. another example is the regenstrief covid-19 dashboard, deployed to support public health and health systems monitor the evolving situation in the state of indiana [18]. community coordination and programs once a pandemic is declared, public health agencies activate a number of “respond” and “recover” activities. these efforts seek to mobilize community-based organizations and public health programs to help individuals, families, and at-risk populations. examples include establishing additional screening or testing locations to identify impacted populations, targeted testing efforts in specific locations (e.g., nursing homes, food processing plants), or erecting field hospitals that might serve as triage sites or post-acute recovery centers. public health agencies also initiate programs that address social needs such as housing for individuals without a safe place to isolate, or feeding individuals who are food insecure during quarantine. these programs are typically coordinated with governmental social services agencies and community-based organizations that may manage the programs or contribute volunteers to ensure sufficient operation. communications & automated assistance communications and automated assistance solutions are critical across all phases of a pandemic but are primarily used during the “respond” phase. government agencies, providers, and payers may all experience an influx of questions from individuals wanting to understand new policies, check symptoms, or find assistance. solutions such as virtual assistants, conversational agents and chatbots may be employed to broadly communicate changes in local guidelines, automatically answer common questions about the pandemic, and triage more complex questions to the appropriate sources of information. return to work as the pandemic wanes and social distancing measures gradually lift, focus shifts to restoring businesses and services. businesses that have been impacted by the pandemic will be eager to leveraging informatics and technology to support public health response: framework and illustrations using covid-19 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi open, yet returning to the workplace before a therapeutic drug or vaccine are available poses risks to front-line employees and organizations. employers need to plan for a safe way to resume operations. these solutions may guide the transition of employees back into work environments and inform critical business processes to ameliorate negative economic impacts from the pandemic. decision-makers are faced with a sense of urgency: when to reopen and how to do so in a responsible manner. such decisions require analyzing and balancing numerous factors to support tailoring evidence-based return to workplace policies for different sites and job roles. factors include monitoring local infection rates and population health trends; gathering and monitoring employee symptoms, assessing their status and referring employees to appropriate testing and medical care; weighing employee vulnerability; understanding state and local regulations; and responding to a range of employee questions in a scalable and comprehensive way. business continuity and resiliency business continuity and resiliency solutions are focused on anticipating and addressing disruptions to business operations and span the “prepare” and “respond” phases of the pandemic. business continuity solutions may help organizations more easily transition to remote working, keep essential systems running for users, and bolster cloud environments. supply chain disruption to ensure smooth operations across an organization’s supply chain, solutions addressing potential disruptions to supply chains span all three phases of the pandemic response. proactive investment in these solutions can ensure that key materials and parts have backup suppliers and customers can continue to access essential products. new ways of working solutions that enable new ways of working look to the future across communication and business continuity and span the “respond” and “recover” phases of the pandemic. employers may invest in solutions that enhance productivity, collaboration, and learning opportunities for employees who are working from home, learning from home, or transitioning to new business processes. mapping we mapped ibm’s existing commercial solutions and technology assets to the pandemic framework, which identified some gaps in capabilities and opportunities for building new products where we could make the largest impact based on our resources and the needs of our stakeholders. the company responded quickly, embraced a change in culture by breaking down silos, and united behind common goals to either integrate and bundle existing products and services to address urgent customer requirements or to develop new solutions with speed and agility. a few of the new solutions that were developed based on this mapping are described in the results section. leveraging informatics and technology to support public health response: framework and illustrations using covid-19 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi results to illustrate the framework, we present two case examples that detail how informatics and technology are supporting the u.s. response to covid-19. these examples represent early findings from technologies actively in use, which may evolve further as the pandemic continues. both examples are from the communications and automated assistance category in figure 2. the weather channel covid-19 information hub the weather channel app and weather.com website provide weather forecasts, current conditions, interactive radar, satellite maps, real-time severe weather alerts, and offer tools that predict local risk of flu or seasonal allergy symptoms up to 15 days in advance at a city level [19,20]. combined, the website and app serve more than 300 million monthly users globally. as covid-19 spread, the weather channel team developed and deployed in less than 1 month a covid-19 information hub (see weather.com/coronavirus) [21]. the hub provides interactive maps, data on confirmed cases, trend graphs, a q&a chatbot, and news about covid-19. the hub, which runs on a hybrid cloud infrastructure, uses watson ai to integrate relevant covid19 data from the who, cdc, and many state as well as local governments every 30 minutes. where available, data is provided at the county level in the united states [22]. for those seeking additional data, ibm created a separate interactive dashboard, built using ibm cognos analytics on ibm’s public cloud, available at https://accelerator.weather.com. the dashboard provides users, such as researchers, data scientists, and media, with analysis and filtering of regional covid-19 data. users can drill down to the region, country, state, and even county and leverage different visualizations (charts, maps, graphs) to examine case as well as mortality trends. since launching on march 26, the weather channel covid-19 hub has seen an average of 2.9 million visitors daily and more than 299 million visits (as of june 28, 2020). the ‘covid-19 q&a with watson’ chatbot has answered more than 2.2 million questions, with “signs and symptoms” being the most popular topic. in a survey of users in april 2020 to gather reaction to the covid19 hub, participants (n=5,422) expressed a high degree of satisfaction (mean 4.38 using a 5-point likert scale). the most desired information focused on areas where cases are concentrated (63%), severity of cases in their local area (62%), predictions for cases in their area (60%), predictions for when the covid-19 outbreak would end (58%), and for confirmed cases (54%). watson assistant for citizens healthcare providers and payers, government agencies, and businesses faced staggering increases in telephone call volume as a result of the covid-19 pandemic. patients, employees, and citizens have questions requiring timely and accurate responses about covid-19 symptoms and case counts, how and where to get tested, what to do if they recently traveled, whether schools and facilities are closed, what a facility’s emergency plan is, whether events are cancelled or postponed, and more. the rapid pace of change in the evolution of the pandemic is further challenging communications. from tracking the disease and local response, to keeping up with the leveraging informatics and technology to support public health response: framework and illustrations using covid-19 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi emerging clinical and public health science, organizations must ensure that their communication is accurate, timely and up-to-date. vetting and curating that content is no small task. institutions are establishing call centers and deploying virtual agents to assist in providing accurate, reliable and timely answers to common questions related to covid-19. watson assistant, a conversational ai platform that supports both multi-channel text and speech-based interfaces, combined with natural language processing technology and watson discovery, an enterprise ai search technology for unstructured data, enables virtual agents to dynamically crawl the cdc website daily for the most current covid-19 guidance as well as state websites and local sources about school closings and news. in table 2 we highlight three institutions that used watson assistant to manage inquiries from the public when staff resources were limited. the time required to design, develop and deploy the conversational, ai-enabled virtual agents ranged from 2 to 14 days. the benefits of watson assistant are that it is able to use conversational ai through many channels, and it effectively handles voice in multiple languages. table 2. various applications of watson assistant in support of covid-19 response during which users interacted via voice, text or the internet to ask questions about getting tested or accessing services during the pandemic. *choa data represents interactions from march 26 through june 3, 2020. **city of austin, texas and university of arkansas for medicine sciences data represents interactions during april 2020. organization children’s hospital of atlanta* city of austin, texas** university of arkansas for medicine sciences** description of technology deployed in response to covid-19 pediatric covid-19 assessment tool [23] city information chatbot [24] covid-19 screening survey agent [25] # unique conversations 10,414 15,998 3,514 # questions asked during conversation -24,378 7,480 # conversations where advice given or information resources provided 7,729 23,159 6,956 % conversations with a successful outcome 74% 95% 93% design and implementation time 2 days 7 days in english; 14 days in spanish 9 days leveraging informatics and technology to support public health response: framework and illustrations using covid-19 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi the first is the children’s hospital of atlanta (choa), which implemented a covid-19 pediatric assessment tool to help parents answer questions pertaining to their child, such as what should be done if a child has a fever and/or cough?; and what should be done if a child may have been around someone with covid-19 (exposed) but has no symptoms? the tool used decision tree analysis to evaluate a child’s symptoms (e.g. fever, marked lethargy, coughing, cyanosis). importantly, the tool presented content at an appropriate reading level for a diverse lay audience. the virtual agent suggested next steps for a parent to take (e.g. advice to stay home, see a doctor, call 911) according to choa’s established protocols. the bilingual tool handled multiple channel mediums (e.g., english and spanish text, english voice). the second is the city of austin, texas, the 11th largest city in the united states with more than 990,000 residents, which deployed a bilingual (english and spanish) chatbot to respond to citizens. the 24x7 virtual chatbot facilitated questions and answers about the cdc’s covid-19 recommendations, stay home orders, local screening availability, operating guidance and resources for businesses, job loss and unemployment services, homeless benefits including shelter and financial assistance, senior citizens, and building permits and inspections for developers. the third represents online and telephone screening for covid-19 at the university of arkansas for medicine sciences (uams) for adults aged 18 years and older residing in arkansas who have no covid-19 symptoms. ibm collaborated with two uams physicians to implement a pre-visit covid-19 screening survey. pregnancy screening questions and educational materials were also added. when the survey is completed by the user, the virtual assistant sends an email containing the answers to uams’ covid-19 test center so that the patient information is waiting for them when they arrive to be tested. a mobile covid-19 triage clinic helps to speed response. depending on responses, an interactive video consult may be conducted with referral to appropriate response teams. discussion we describe a framework designed to characterize how informatics and technology can support public health preparedness, recovery, and response during a pandemic. the framework maps the roles that informatics and technology play during a pandemic onto the major phases of a pandemic and the stakeholders involved. the framework further encapsulates the complexity of multiple sectors working together to respond and recover from a pandemic. underlying this framework are three enabling forces. leading businesses are investing in ai and cloud to predict future outcomes, create intelligent workflows that automate decisions and experiences, and empower people to do higher value work. data and security are fueling digital transformation. ai and advanced analytics are unlocking the value of trusted data through insights. the convergence of these forces is catalyzing innovation in the creation of scalable cognitive solutions with intelligent interfaces to rapidly address disruptive change such as a pandemic. the covid-19 pandemic highlights the importance of informatics to public health in an interconnected world and at the local level. the concept of public health 3.0 [8] requires a robust, interoperable infrastructure that supports data management and exchange between public health and other sectors. to fully achieve public health 3.0, patients, citizens, healthcare professionals, leveraging informatics and technology to support public health response: framework and illustrations using covid-19 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi public health officials, academics, and businesses all need to play a role in the development and use of health information technology and applications for pandemic preparedness, response and recovery. investment in solutions for disease modeling for public health agencies are needed in the same way as solutions for working from home, selling goods and services from the cloud, and returning to the workplace. the examples given in this paper to illustrate framework components are works-in-progress, and they are just a few of the many technologies used for public health preparedness, response, and recovery against covid-19. evaluation studies of these and other approaches and technologies are required to fully understand their contributions to preparedness, recovery, and response for specific populations. conclusion the framework illustrates how broad stakeholder groups across multiple sectors leverage technology and informatics during a pandemic. while this framework shows how each informatics methodology or tool fits into the landscape of public health preparedness, response, and recovery, studies are required to examine each tool and its contribution to a given phase of public health response or outcomes on specific populations. understanding how these technologies performed, what worked, what was not effective and what could have worked better is critical to success in the next pandemic. acknowledgments we would like to gratefully acknowledge the contributions and support of sheri bachstein, carol bales, and melissa medori from the weather channel and edward cadow, judy kelly, preeth muthusamy, thomas nisbet, steve payment, paul roma, elizabeth transier, michael volpe, and leigh williamson from watson health. no financial disclosures competing interests william kassler, hema karunakaram, kyu rhee, and jane snowdon are employees of ibm corporation. brian dixon has no competing interests. references 1. obeid js, davis m, turner m, et al. 2020. an ai approach to covid-19 infection risk assessment in virtual visits: a case report. j am med inform assoc. 27(8), 1321-1325. doi:https://doi.org/10.1093/jamia/ocaa105. epub 2020-07-04. 2. paules ci, eisinger rw, marston hd, et al. 2017. what recent history has taught us about responding to emerging infectious disease threats. ann intern med. 167(11), 80511. doi:https://doi.org/10.7326/m17-2496. epub 2017-11-14. pubmed https://doi.org/10.1093/jamia/ocaa105 https://doi.org/10.7326/m17-2496 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29132162&dopt=abstract leveraging informatics and technology to support public health response: framework and illustrations using covid-19 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi 3. organization wh. coronavirus disease (covid-19) situation reports. 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports. 4. organization wh. coronavirus disease (covid-19) situation report — 160. 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200628-covid-19sitrep-160.pdf?sfvrsn=2fe1c658_2 (accessed june 30, 2020). 5. hurt b, kligerman s, hsiao a. 2020. deep learning localization of pneumonia: 2019 coronavirus (covid-19) outbreak. j thorac imaging. 35(3), w87-w89. doi:https://doi.org/10.1097/rti.0000000000000512. epub 05-2020. pubmed 6. mei x, lee h-c, diao k-y, et al. 2020. artificial intelligence–enabled rapid diagnosis of patients with covid-19. nat med. 35(3), w87-89. doi:10.1038/s41591-020-0931-3. epub 2020-05-19. pubmed 7. vaishya r, javaid m, khan ih, et al. 2020. artificial intelligence (ai) applications for covid-19 pandemic. epub 2020-04-14. diabetes metab syndr. 14(4), 337-39. doi:https://doi.org/10.1016/j.dsx.2020.04.012. pubmed 8. desalvo k, wang yc. health informatics in the public health 3.0 era: intelligence for the chief health strategists. j. public health manag. pract. 2016;22 suppl 6, public health informatics (suppl 6):s1-s2 doi: 10.1097/phh.0000000000000484. epub 2016-09-30. 9. desalvo kb, wang yc, harris a, et al. 2017. public health 3.0: a call to action for public health to meet the challenges of the 21st century. prev chronic dis. 14( e78). doi:https://doi.org/10.5888/pcd14.170017. epub 09-2017. pubmed 10. holloway r, rasmussen sa, zaza s, et al. 2014. updated preparedness and response framework for influenza pandemics. mmwr. 63(6). https://www.cdc.gov/flu/pandemicresources/pdf/mmwr-rr6306.pdf. pubmed 11. centers for medicare & medicaid services (cms) . pandemic influenza operations and response plan, september 2009. https://www.cms.gov/about-cms/agencyinformation/h1n1/downloads/pandemicplan.pdf. 12. getz ka, wenger j, campo ra, et al. 2008. assessing the impact of protocol design changes on clinical trial performance. am j ther. 15(5), 450-57. doi:https://doi.org/10.1097/mjt.0b013e31816b9027. pubmed 13. getz ka, stergiopoulos s, short m, et al. 2016. the impact of protocol amendments on clinical trial performance and cost epub 2016-02-22. ther innov regul sci. 50(4), 436-41. doi:https://doi.org/10.1177/2168479016632271. pubmed 14. lamberti mj, wilkinson m, donzanti ba, et al. 2019. a study on the application and use of artificial intelligence to support drug development. epub 2018-04-26. clin ther. 41(8), 1414-26. doi:https://doi.org/10.1016/j.clinthera.2019.05.018. pubmed https://doi.org/10.1097/rti.0000000000000512 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=32205822&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=32427924&dopt=abstract https://doi.org/10.1016/j.dsx.2020.04.012 https://pubmed.ncbi.nlm.nih.gov/32305024/ https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=28880837&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=25254666&dopt=abstract https://doi.org/10.1097/mjt.0b013e31816b9027 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18806521&dopt=abstract https://doi.org/10.1177/2168479016632271 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=30227022&dopt=abstract https://doi.org/10.1016/j.clinthera.2019.05.018 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=31248680&dopt=abstract leveraging informatics and technology to support public health response: framework and illustrations using covid-19 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 13(1):e1, 2021 ojphi 15. wilkinson m, young r, harper b, et al. 2019. baseline assessment of the evolving 2017 eclinical landscape. ther innov regul sci. 53(1), 71-80. doi:https://doi.org/10.1177/2168479018769292 epub 2018-04-26. pubmed 16. reeves jj, hollandsworth hm, torriani fj, et al. 2020. rapid response to covid-19: health informatics support for outbreak management in an academic health system. j am med inform assoc. 27(6), 853-59. doi:https://doi.org/10.1093/jamia/ocaa037. epub 202006-01. pubmed 17. douglas jv, bianco s, edlund s, et al. 2019. stem: an open source tool for disease modeling. health secur. 17(4), 291-306. doi:https://doi.org/10.1089/hs.2019.0018. epub 07-2019. pubmed 18. dixon be, grannis sj, mcandrews c, et al. 2021. leveraging data visualization and a statewide health information exchange to support covid-19 surveillance and response: application of public health informatics. j am med inform assoc. in press. doi:https://doi.org/10.1093/jamia/ocab004. epub 01-2021. pubmed 19. flu season is here! stay informed by using flu insights with watson in the weather channel app. 2020. https://newsroom.ibm.com/flu-season-is-here-stay-informed-by-usingflu-insights-with-watson-in-the-weather-channel-app. 20. chukura r, sulpovar m. how ai and weather data can help you plan for allergy season, 2020. https://www.ibm.com/blogs/think/2020/04/the-question-this-spring-is-it-covid-orallergies/. 21. buscemi j. the self-assembled ibm team behind two widely used covid-19 data tracking tools. 2020. https://newsroom.ibm.com/index.php?s=34178&item=31953. 22. ibm offers free tools based on trusted data to track covid-19 cases on your phone and online. 2020. https://newsroom.ibm.com/2020-03-25-ibm-offers-free-tools-basedon-trusted-data-to-track-covid-19-cases-on-your-phone-and-online. 23. choa covid-19 pediatric assessment tool. https://covid-choa.mybluemix.net/dashboard?view=chat. 24. city of austin covid-19 free assessment & testing. https://covid19.austintexas.gov/s/?language=en_us. 25. novel coronavirus uams. (covid-19) screening. https://uams.virtriage.com/#/uamscovid19. https://doi.org/10.1177/2168479018769292 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=29714600&dopt=abstract https://doi.org/10.1093/jamia/ocaa037 https://doi.org/10.1089/hs.2019.0018 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=31433284&dopt=abstract https://doi.org/10.1093/jamia/ocab004 https://pubmed.ncbi.nlm.nih.gov/33480419/ leveraging informatics and technology to support public health response: framework and illustrations using covid-19 abstract introduction methods prepare respond recover a framework for pandemic preparedness, response, and recovery benchside bedside disease investigation, modeling and monitoring community coordination and programs communications & automated assistance return to work business continuity and resiliency supply chain disruption new ways of working mapping results the weather channel covid-19 information hub watson assistant for citizens discussion conclusion acknowledgments competing interests references crowdinforming during public health emergencies: a commentary crowdinforming during public health emergencies: a commentary 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 1, 2011 crowdinforming during public health emergencies: a commentary rebecca roberts, md 1 , edward mensah, phd 2 1 john stroger hospital of cook county, chicago 2 university of illinois at chicago, school of public health during the recent 2009 novel h1n1 influenza pandemic, public health safety efforts included prevention and mitigation actions such as mass vaccination programs, community education focused on infection control, social distancing and how to avoid contracting and spreading influenza.[1-3] there were also programs to rapidly deploy caches of ventilators, antivirals and personal protective equipment to treat and reduce transmission of influenza infection.[1,3,4] despite these efforts, many became ill.[12] where and when to seek medical care was part of the public health education message. the problem becomes continuing to meet concurrent public health prevention goals, plus ongoing medical obligations with existing staff and space.[4,6,7] the same medical staff members delivering antiviral medications to those exposed and running mass vaccination programs were also treating the ill. in addition, aggressive viral culture acquisition and special processing was instituted.[1,9] screening for febrile employees and exposed personnel in high risk facilities was started so that antiviral prophylaxis could be rapidly administered. alternate care sites were initiated to address the increased volumes and to sequester possibly infective patients. [1] hospitals often make plans to delay routine care and redeploy the staff and treatment space if the influenza surge required this step.[6,7] in addition to all that new activity, some jurisdictions instituted new influenza-like-illness (ili) reporting requirements for hospitals.[2] even normal staffing levels may be insufficient to meet these new responsibilities and existing staff numbers may be further reduced due to illness during this pandemic.[10] emergency departments (eds) are a good place to begin addressing load distribution during patient surge events such as the 2009 novel h1n1 pandemic. they are open 24/7, serve all who present for treatment, and do not incur the scheduling delays associated with primary care or other office-based appointments. they are prepared to address the most severe acuity of illness and are in hospitals which are often centrally located and highly familiar to the local community. indeed, unprecedented patient surges were reported during the 2009 influenza season. [1, 8] in ojphi, vol 2, no. 1, bob mcleod introduced a novel combination of agent based modeling (abm), electronic medical record dashboards to predict ed waiting room times, and crowdinforming as a method to redistribute patients seeking ed care.[11] the purpose is to balance area hospital waiting room loads during pandemics surges. this is a very innovative idea with important applications in medicine and public health. in short, they propose using emr dashboards to estimate real-time ed patient waiting times for area hospitals.[11,12,13,14] this information is widely broadcast using the internet. the aim is crowdinforming during public health emergencies: a commentary 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 1, 2011 to let potential ed patients add waiting room time to their decision-making on when and which ed to visit for current symptoms. this would help both patients seeking care and hospitals that often become overburdened during influenza season. we postulate that the model and the dissemination of the data have further important purposes. the primary goal for any new medical innovation is better health in the community. with this in mind, we propose additional considerations to better inform decision making. we also recommend that the abm and waiting room data are first communicated to key users such as the eds, hospitals, clinics and local public health departments; enabling them to better collaborate in serving the community and to organize their staff and facilities to best address anticipated surge changes. the abm model and crowdinforming might be inferred to refer only to ili patients seeking emergency care and the waiting times might be construed as first-come, first-serve. even during a pandemic, the majority of ed patients are there for other emergencies. hospitals in santiago, chile, reported that 78% of all ed visits were for influenza.[8] however, during the epidemic peak in chicago, slightly more than 14% of all ed visitors had ili.[2] among all u.s. ambulatory visits, approximately 16% were ili and australia’s flutracking netted approximately 9% ili visits during the peak.[5,15] another key feature of ed waiting time is the triage procedure. universally, systems are used to ensure that patients of high acuity are treated more rapidly than those with chronic, self-limited illness, or conditions where treatment success is not time-dependent. [16] in short, based on complex triage rules, severity of illness defines who waits the longest.[17] in the crowdinforming model, this same concept would ideally apply to those who are deciding to seek care or considering long-distance travel to go to an ed with shorter waiting times. the problem becomes the degree of medical knowledge required to make these decisions wisely. a patient with a potential myocardial infarction (heart attack) or limb-threatening injury would wisely take an ambulance to the closest emergency department and expect to be seen immediately even in an ed with long average waiting times. a patient with very mild ili symptoms could safely wait several hours to see a clinician. at the same time, one would not want the mildly ill but contagious, coughing influenza patient to ride public transportation for an hour then wait in an ed infecting others. more importantly, antivirals are most effective in disease treatment and transmission prevention when started very early in the course of illness while patients may not seek care for days or wait until they become quite severe. [4,8,17] these issues are difficult for medical professionals to solve and may be even more difficult for potential patients or those who must develop public health messages to inform the community.[3,10,18,19] another resource that may inform this new modality is the literature on ed waiting room patients who left without being seen (lwbs). the literature indicates that longer waiting times, younger age and less severe disease are associated with lwbs.[20-23] however, this obscures the fact that even though age and acuity are statistically associated with waiting room behavior, some who leave do have high acuity problems.[17,21] the statistical tests gain strength from very large sample sizes. an important proportion of lwbs patients are hospitalized within a week.[21] the unintended consequence of crowdinforming might be to influence a critically ill crowdinforming during public health emergencies: a commentary 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 1, 2011 person to defer care or travel inordinate distances when they would best be seen at the closest hospital and triaged for immediate care. current staffing and medical supplies in departments critical to patient care must be taken into consideration when releasing information to the public that will cause rapid increases at the slower hospitals. staff configuration at individual eds and associated hospital wards, intensive care units, laboratories, pharmacies and radiology departments may need to be adjusted before crowdinforming induces dramatic change.[7,12] eds that are currently slow and might expect to remain slow could become swamped in the short-term. at the same time, overloaded hospitals may have instituted back-up staff and supply procedures for currently anticipated surge volumes, only to have the problems evaporate. for these reasons, we recommend that local public health departments, ems, hospitals, and public education professionals should be closely involved in the formulation and response to crowdinforming before messages are delivered to the public. this could foster cooperation and collaboration in the deployment of space, staff and supply resources throughout an area to best serve the public health.[3,6,7] references 1. fagbuyi db, brown km, mathison dj, kingsnorth j, morrison s, saidinejad m, greenberg j, knapp m, chamberlain jm. a rapid medical screening process improves emergency department patient flow during surge associated with novel h1n1 influenza virus. ann emerg med. 2011; 57:52-9. 2. city of chicago department of public health. pandemic influenza a (h1n1) in chicago, 2009. communicable disease information. february 2010. available at: http://www.cityofchicago.org/content/dam/city/depts/cdph/infectious_disease/communicable _disease/ip_cdinfo_feb2010_pandemicflu.pdf. assessed december, 2010. 3. bishop jf, murnane mp, owen r. australia’s winter with the 2009 pandemic influenza a (h1n1) virus. nejm. 2009; 361:2591-2594. 4. bradt da, drummond cm. avian influenza pandemic threat and health systems response. emerg med australas. 2006; 18:430-43. 5. centers for disease control and prevention. 2010-2011 influenza season week 50 ending december 18, 2010. dec 23, 2010. available at: http://www.cdc.gov/flu/weekly/ accessed december, 2010. 6. u.s. department of homeland security. target capabilities list – a companion to the national preparedness guidelines. september 2007. available at: http://www.fema.gov/pdf/government/training/tcl.pdf. accessed may 2010. 7. hospital incident command system. external scenario 3: biological disease outbreak – pandemic influenza. available at: http://www.emsa.ca.gov/hics/files/ext_03.pdf. accessed april 2010. 8. torres jp, o’ryan m, herve b, espinoza r, acuna g, manalich j, chomali m. impact of the novel influenza a (h1n1) during the 2009 autumn-winter season in a large hospital setting in santiago, chile. clin infect dis. 2010; 50:869-70. http://www.cityofchicago.org/content/dam/city/depts/cdph/infectious_disease/communicable_disease/ip_cdinfo_feb2010_pandemicflu.pdf http://www.cityofchicago.org/content/dam/city/depts/cdph/infectious_disease/communicable_disease/ip_cdinfo_feb2010_pandemicflu.pdf crowdinforming during public health emergencies: a commentary 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 1, 2011 9. cheng pk, wong kk, mak gc, wong ah, mg ay, chow sy, lam rk, lau cs, ng kc, lim w. performance of laboratory diagnostics for the detection of influenza a (h1n1) virus as correlated with the time after symptom onset and viral load. j clin virol. 2010; 47:182-5. 10. lipsitch m, phil d, riley s, phil d, cauchemez s, ghani ac, ferguson nm. managing and reducing uncertainty in an emerging influenza pandemic. nejm. 2009; 361;2:112-15. 11. mcleod b. agent based modeling of “crowdinforming” as a means of load balancing at emergency departments. online journal of public health informatics. 2010 vol 2, no. 1. 12. gunal mm, pidd m. understanding accident and emergency department performance using simulation. proceedings of the 2006 winter simulation conference. 2006, pages 44652. 13. bonabeau e. agent-based modeling: modeling and techniques for simulating human systems. pnas. 2002; 99:7280-87. 14. laskowski m, mcleod rd, friesen mr, podaima bw, alfa as. models of emergency departments for reducing patient waiting times. plos one. 2009; 4:e6127. 15. carlson sj, dalton cb, durrheim dn, fesja j. online flutracking survey of influenza-like illness during pandemic (h1n1) 2009, australia. emerg inf dis. 2010; 16,12:1960-1962. 16. bernstein sl, argonsky d, duseja r, epstein s, handel d, hwang u, mccarthy m, mcconnell kj, pines jm, rathlev n, schafermeyer r, zwemer f, schull m, asplin br. the effect of emergency department crowding on clinically oriented outcomes. acad emerg med. 2009; 16:1-10. 17. zarychanski r, stuart tl, kumar a, doucette s, elliot l, kettner j, plummer f. correlates of severe disease in patients with 2009 pandemic influenza (h1n1) virus infection. cmaj. 2010; 182:257-64. 18. osterholm mt. preparing for the next pandemic. nejm. 2005; 352:1839-42. 19. kendal ap, macdonald ne. influenza pandemic planning and performance in canada, 2009. can j public health. 2010; 101:447-53. 20. kennedy m, macbean ce, brand c, sundararajan v, mcd taylor d. review article: leaving the emergency department without being seen. emerg med australas. 2008; 20:30613. 21. baker dw, stevens cd, brook rh. patients who leave a public hospital emergency department without being seen by a physician. jama. 1991; 266:1085-90. 22. kulstad eb, hart km, waghchoure s. occupancy rates and emergency department work index scores correlate with leaving without being seen. westjem. 2010; 11:324-28. 23. baibergenova a, leeb k, jokovic a, gushue s. missed opportunity: patients who leave emergency departments without being seen. healthcare policy. 2006 1;35-41. layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts mining surveillance data: does radiation treatment of prostate cancer cause rectal cancer? john w. morgan*1, 2, brice jabo1, mark e. ghamsary1 and kevork kazanjian3 1dept epidemiology, biostatistics & population medicine, loma linda university school of public health, loma linda, ca, usa; 2desert sierra cancer surveillance program, region 5 of california cancer registry, loma linda, ca, usa; 3dept of surgery, division of surgical oncology, loma linda university school of medicine, loma linda, ca, usa objective we sought to assess whether external beam radiation (rad) treatment of prostate cancer, that exposes the rectum to ionizing radiation, was followed by increased hazards for rectal cancer, relative to prostatectomy (surg). introduction prostate cancer (pc) is the most common invasive cancer diagnosed among us men. the majority of pcs are organ-confined at diagnosis making them candidates for treatment using rad, surg, or other protocols. several studies have provided preliminary evidence that radiation treatment of prostate cancer may increase subsequent rectal cancer risk (1-2). data specifying type of rad treatment of pc was not available for the study period. methods we conducted record linkage for all 322,327 organ confined new prostate cancers and 53,204 new rectum and rectosigmoid junction (rectal) cancers among california males from 1988-2009, identifying men diagnosed with rectal cancer more than five years following treatment of organ-confined prostate cancer with rad or surg. among the men treated with rad vs surg, the cox proportional hazards ratio (hr) for subsequent rectal cancer was assessed. demographic covariates included: race/ethnicity as asian/other (a-o), non-hispanic black (nhb), hispanic (hisp), and non-hispanic white (nhw), and socioeconomic status quintiles (1-5 highest). other covariates included age, as a continuous variable, and year of pc diagnosis. results among the 43,130 men having organ-confined prostate cancer that had been treated with rad only, 166 were diagnosed with rectal cancer more than five years following pc treatment. likewise, 69,104 men treated with surg only, yielded 242 rectal cancer cases more than 5 years later. following is the demographic factor adjusted hazards ratio (hr) for rectal cancer with 95% confidence intervals (ci) contrasting findings for the two pc treatment cohorts: rectal cancer hrrad/surg=1.39; 95% ci=1.12-1.74. hr contrasts for demographic factors included age(hrage= 1.02; 95% ci=1.01-1.04), race/ethnicity(hra-o/nhw= 1.10; 95% ci=0.72-1.67, hrnhb/nhw= 1.19; 95% ci=0.82-1.74 and hrhisp/nhw= 1.01; 95% ci=0.72-1.43), and sescontrasts (hrses1/ses5= 0.95; 95% ci=0.65-1.39), hrses2/ses5=1.20; 95% ci=0.89-1.62, hrses3/ses5= 1.17; 95% ci=0.88-1.55, and hrses4/ses5= 1.14; 95% ci=0.87-1.49). the hr for pc year of diagnosis (hryear= 0.91; 95% ci=0.89-0.94) a protective effect for more recent years. conclusions these findings reveal increased hazards for rectal cancer among organ-confined prostate cancer patients treated with rad, relative to patients treated with surg, that are substantially independent of demographic covariates. treatment of rectal cancer among these patients is further complicated because they are ineligible for radiation treatment of rectal cancer due to the high-dose pelvic radiation received during prostate cancer treatment. further analyses that seek to distinguish roles of different dose and delivery methods for rad are ongoing. keywords radiation; cancer; rectal; prostate; surveilance references 1. e rapiti, g fioretta, hm verkooijen, r zanetti, f schmidlin, h shubert, a merglen, r miralbell, c bouchardy. increased risk of colon cancer after external radiation therapy for prostate cancer. int. j. cancer: 123, 1141–1145 (2008). 2. nn baxter, je tepper, sb durham, da. rothenberger,ba virnig. increased risk of rectal cancer after prostate radiation: a populationbased study. gastroenterology 2005;128:819–824. *john w. morgan e-mail: john.w.morgan@att.net online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e183, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts searching for complex patterns using disjunctive anomaly detection maheshkumar sabhnani*, artur dubrawski and jeff schneider carnegie mellon university, pittsburgh, pa, usa objective disjunctive anomaly detection (dad) algorithm [1] can efficiently search across multidimensional biosurveillance data to find multiple simultaneously occurring (in time) and overlapping (across different data dimensions) anomalous clusters. we introduce extensions of dad to handle rich cluster interactions and diverse data distributions. introduction modern biosurveillance data contains thousands of unique time series defined across various categorical dimensions (zipcode, age groups, hospitals). many algorithms are overly specific (tracking each time series independently would often miss early signs of outbreaks), or too general (detections at state level may lack specificity reflective of the actual process at hand). disease outbreaks often impact multiple values (disjunctive sets of zipcodes, hospitals, multiple age groups) along subsets of multiple dimensions of data. it is not uncommon to see outbreaks of different diseases occurring simultaneously (e.g. food poisoning and flu) making it hard to detect and characterize the individual events. we proposed disjunctive anomaly detection (dad) algorithm [1] to efficiently search across millions of potential clusters defined as conjunctions over dimensions and disjunctions over values along each dimension. an example anomalous cluster detectable by dad may identify zipcode = {z1 or z2 or z3 or z5} and age_group = {child or senior} to show unusual activity in the aggregate. such conjunctive-disjunctive language of cluster definitions enables finding realworld outbreaks that are often missed by other state-of-art algorithms like what’s strange about recent events (wsare) [3] or large average submatrix (las) [2]. dad is able to identify multiple interesting clusters simultaneously and better explain complex anomalies in data than those alternatives. methods we define the observed counts of patients reporting on a given day as a random variable for each unique combination of values along all dimensions. dad iteratively identifies k subsets of these variables along with corresponding ranges of their values and time intervals that show increased activity that cannot be explained by random fluctuations (k is generally unknown and could be 0). the resulting set of clusters maximizes data likelihood while controlling for overall complexity. we have successfully derived a versatile set of scoring functions that allow normal, poisson, exponential or non-parametric assumptions about the underlying data distributions, and accommodate additive-scaled, additive-unscaled or multiplicative-scaled models for the clusters. results we present results of testing dad on two real-world datasets. one of them contains daily outpatient visit counts from 26 regions in sri lanka involving 9 common diseases. the other data contains semisynthetically generated terrorist activities throughout regions of afghanistan (sigacts). both span multiple years and are representative of data seen in biosurveillance applications. figure 1 shows dad systematically outperforming wsare and las. each algorithm’s parameters were tuned to generate one false positive per month in baseline data. the graphs represent average days-to-detect performance of 100 sets with synthetically injected clusters using additive-scaled (as), additive-unscaled (au), and multiplicative-scaled (ms) models of cluster interactions. conclusions we extend applicability of dad algorithm to handle wide variety of input data distributions and various outbreak models. dad efficiently scans over millions of potential outbreak patterns and accurately and timely reports complex outbreak interactions with speed that meets requirements of practical applications. keywords outbreak detection; anomalous clusters; disjunctive anomaly detection; prospective surveillance acknowledgments this material is based upon work supported by the national science foundation under grant no. iis-0911032. references 1. sabhnani m., dubrawski a., schneider j. detection of multiple overlapping anomalous clusters in categorical data. advances in disease surveillance, 2010. 2. shabalin a., weigman v., perou c., nobel a. finding large average submatrices in high dimensional data. annals of statistics 3(3):9851012, 2009. 3. wong w., moore a., cooper g., wagner m. what’s strange about recent events (wsare). j. of machine learning research, 6:19611998, 2005. *robin sabhnani e-mail: sabhnani@cs.cmu.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e14, 2013 food trends and popular nutrition advice online – implications for public health 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi food trends and popular nutrition advice online – implications for public health divya ramachandran*1,2, james kite1, amy jo vassallo1, josephine y chau1, stephanie partridge1,3, becky freeman1, timothy gill1,2 1. prevention research collaboration, sydney school of public health and charles perkins centre, faculty of medicine and health, university of sydney nsw, australia 2. the boden institute of obesity, nutrition, exercise & eating disorders, sydney school of public health and charles perkins centre, faculty of medicine and health, university of sydney nsw, australia 3. westmead applied research centre, faculty of medicine and health, university of sydney nsw, australia abstract objectives: consumers routinely seek health and nutrition-related information from online sources, including social media platforms. this study identified popular online nutrition content to examine the advice and assess alignment with the australian guideline to healthy eating (aghe). methods: we used facebook page “likes” as an indicator of popularity to identify online nutrition and diet content. websites and blogs associated with pages that had more than 100,000 australian likes on 7th september 2017 were included. the dietary advice promoted was collected and compared with the aghe across nine categories (vegetables, fruits, legumes, grains, lean meat, dairy/alternative, fat, sugar, salt) results: nine facebook pages met the inclusion criteria. the four most-liked pages were hosted by celebrities. only two pages and their associated websites had advice consistent with aghe recommendations across all nine categories reviewed. the concept of “real food” was a popular theme online. while most sources advocated increasing vegetable consumption and reducing processed food, other advice was not evidence-based and frequently deviated from the aghe. discussion: health information seekers are exposed to a variety of online dietary information and lifestyle advice. while few public health goals are promoted, there are many contradictions, as well as deviations from the aghe, which can create confusion among health information seekers. public health organisations promoting aghe on facebook are few and not as popular. conclusion: public health organisations need to be more engaged on popular internet platforms such as facebook. the prevailing popular nutrition advice online may increase consumer confusion, scepticism and even avoidance of dietary advice. proactive efforts are needed by public health organisations, in partnership social marketing experts, to create and share engaging and accurate nutrition content. partnership with celebrities should be explored to improve reach and impact of evidence-based diet recommendations online. food trends and popular nutrition advice online – implications for public health 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi keywords: public health, health communication, diet fads, nutrition guidelines, social media, internet correspondence: divya ramachandran, mph; the boden institute, level 2, charles perkins centre, d 17 johns hopkins drive, camperdown nsw 2006 australia; email: divya.ramachandran@sydney.edu.au doi: 10.5210/ojphi.v10i2.9306 copyright ©2018 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. introduction optimal nutrition is important for improved health and wellbeing and reducing the risk of dietrelated health conditions including chronic disease [1]. in australia, the national health and medical research council (nhmrc) publishes the australian dietary guidelines (adg) and the australian guidelines to healthy eating (aghe) for healthy eating based on the best available scientific evidence [2]. however, most australians do not follow recommended guidelines for healthy eating [3]. consumers have reportedly found dietary guidelines confusing [4]. this confusion is aggravated by exposure to conflicting and changing nutrition information [5]. the continuously evolving body of nutrition evidence and inaccurate news media reporting contributes to the public perception that “the science keeps changing” [6]. exposure to these contradictions provokes negative responses ranging from consumer scepticism to anger and anxiety [7]. in some, it induces a sense of inaction and avoidance of all guidelines [5,6] or a backlash which can potentially deter intentions to adopt healthy lifestyle behaviours [5]. in others, it promotes an active search for ‘truth’ [7] or looking for information from sources perceived to be neutral and free from hidden agendas [8]. online health and nutrition information seeking is a common phenomenon [9]. a national survey in the us reported that nearly 60% of all adults accessed health information online with over a quarter accessing it through social media [9]. nearly 32% of us adults shared their perceptions and knowledge of health online, and 9% of social media users had started or joined a health-related group. information on diet, nutrition, vitamins and supplement information has been reported as one of the more common reasons why people use the internet [10]. a similar phenomenon is evident in australia, with a study in western australia showing a dramatic increase in online nutrition information seeking, from less than 1% in 1995-2001 to 33.7% of all adults in 2012 [11]. in order for public health organizations to address nutrition misinformation, it is essential to first understand the current online nutrition information landscape. this study aimed to identify popular online nutrition content in australia and examine the dietary advice promoted and its alignment with the aghe. food trends and popular nutrition advice online – implications for public health 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi methods study design and approach facebook is the most popular social media platform [12] and searching for health information on social media is a growing phenomenon [13]. we therefore, used facebook “likes” as an indicator of popularity to identify most popular diet and nutrition content producers in australia. the “about” section of facebook pages provide a description of the page including links to associated websites and blogs. these websites or blogs contained the page hosts’ food philosophy and diet advice. in order to do a contained study, we excluded analysing individual facebook posts, but extracted relevant content from the “about section” of the facebook page, and from the publicly available content on associated websites or blogs. sample selection socialbakers [14], a social media analytics company, lists pages with most likes on their website. we used data available on socialbakers on 7th september 2017 and identified the most “liked” facebook pages in australia that made recommendations on healthy eating. all categories of pages were examined, however only the categories “celebrities”, “brands” and “lifestyle” under “communities” contained the pages of interest. pages that had 100,000 australian “likes” or more under these three categories were extracted (n =1304). we then excluded pages that were not related to food (n= 1120), food and beverage brands, industry groups, and food retailers (n = 136), recipe pages (n = 28), and news service pages that simply channelled health and nutrition news articles from various sources but did not develop original content (n=7), and thirteen pages remained. three of these pages (clean eating recipes, just eat real food, fitness recipes) catered to paleo, vegan, gluten-free, dairy-free lifestyles; and one page (skinnytastes) promoted low-calorie eating. however, the content in these pages and associated websites did not contain explicit statements comparable with aghe food groups, and so were subsequently excluded from the sample, leaving a final sample of nine pages for analysis. data collection we used a two-step approach to first, describe the popular facebook pages, and second, to examine the dietary advice made by the authors of pages on their websites or blogs. data recorded included facebook page name, associated website/blog link, and the number of global and australian page ‘likes’. all websites had either main or sub-pages or blog posts that indicated author's food preferences and advice on what to eat or not. step 1 – description of popular facebook pages in order to describe the pages, we developed a unique coding scheme to categorise type of author, diet pattern or theme, references to dietary guidelines, using the definitions below. author type the type of page host, including ‘celebrities’, ‘weight loss programs’, ‘dietitians/nutritionists’, or ‘other’ food trends and popular nutrition advice online – implications for public health 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi diet pattern or theme whether the page promoted a particular theme or pattern of diet, including: • ‘real food’ (a diet consisting of organic whole foods that are as close to their natural state as possible, with an avoidance of processed foods); • ‘paleo’ (consumption of foods presumed to have been the foods available to or consumed by humans during the paleolithic era. therefore, grains, dairy, oil, sugar, processed foods are all excluded) • ‘calorie-count’ (diets that recommend tracking calories consumed in a day) • ‘raw’ (diets that emphasize mostly raw food, rather than cooked) • ‘vegan’ (diet based on plant-based foods, avoiding animalbased foods including dairy, eggs and honey) • ‘sugar free’ (a diet that emphasizes elimination of almost all sugar from the diet) • dairy free (a diet devoid of dairy products) • gluten free (a diet devoid of wheat, wheat products and barley) • ‘other’ (other diet themes – e.g. fruit and vegetables for children, protein powders, gut and psychology syndrome or gaps diet) reference to dietary guidelines whether there was any reference or mention of alignment with any government-backed dietary guidelines. step 2 – assessment of the dietary advice and alignment with aghe data extraction for this step was guided by three questions: 1. do the authors recommend eating, limiting, and/or avoiding food groups? 2. do authors specify items to eat, limit, and/or avoid within the food groups? 3. do authors prescribe the selection of food in any manner (for example: organic, grass-fed, pesticide-free, non-gmo, canned, frozen), or cooking technique (for example: soaking, fermenting). the content extracted was recorded verbatim along with a link to the content. two reviewers (dr and av) independently coded the content, and summarised diet advice using the three questions listed above as a guide. where coding differences could not be reconciled between the two primary reviewers, they were referred to a third reviewer (jk). examples of coding are available in the appendix. we then assessed the coded summaries for alignment with food trends and popular nutrition advice online – implications for public health 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi the aghe recommendations for each of the five food groups vegetables, fruit, lean meat, grain, dairy/alternative; we coded legumes separately as they are included under vegetables as well as lean meat food groups in aghe; and for fat, sugar and salt. results step 1 – description of popular facebook pages as described above, nine pages were found to meet the eligibility criteria for inclusion: michelle bridges 12 week body transformation (12wbt), jamie oliver, chef pete evans (pete evans), i quit sugar (iqs), the healthy mummy (healthy mummy), super healthy kids (shk), quirky cooking, weight watchers aunz (weight watchers), and rebel dietitian. as shown in table 1, these nine pages had nearly 16 million ‘likes’, with 2,967,788 ‘likes’ from australia. 12wbt had the highest number of australian likes at 778,066, whereas rebel had the least of those sites in our sample at 104,132 likes. the four most popular pages (12wbt, jamie oliver, pete evans and iqs) were hosted by celebrities. two pages (shk and rebel dietitian) were hosted by registered dietitians, two pages (weight watchers and healthy mummy) were commercial weight loss programs. all pages except three (healthy mummy, shk and weight watchers) promoted “real food”or the shift to consuming organic whole foods that are as close to their natural state as possible, with an avoidance of processed foods. in addition, a variety of dietary patterns and themes such as paleo, gluten-free, sugar-free, raw, vegan and their variants were promoted. these niche diets were promoted as healthy ways of eating for everybody and not limited only to specific patient groups such as coeliac patients or those with allergies and intolerances. six of the pages (12wbt, jamie oliver, iqs, healthy mummy, weight watchers, and shk) quoted or referenced governmentrecommended dietary guidelines including those of australia, uk and us. two pages (12wbt and weight watchers) recommended tracking calories consumed. table 1. top nine facebook pages in australia that provide nutrition advice (as on 7th september 2017) facebook page url australia n likes total likes author diet type / theme reference to dietary guidelines michelle bridges 12 week body transform ation (12wbt) https://w ww.12wb t.com/ 728 214 778 066 celebrity real food, calorie-count yes australian dietary guidelines [2] jamie oliver http://ww w.jamieol iver.com/ 450 198 6 525 310 celebrity real food yes uk guidelines [26] food trends and popular nutrition advice online – implications for public health 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi chef pete evans (pete evans) http://ww w.thepale oway.co m 440 339 1 528 167 celebrity paleo, real food no i quit sugar (iqs)* https://iq uitsugar.c om/,http:/ /www.sar ahwilson. com 402 756 980 875 celebrity sugar free, real food yes – australian dietary guidelines [2] the healthy mummy (healthy mummy) https://w ww.healt hymumm y.com/ 312 367 361 663 other other –includes healthy mummy protein shakes yes – australian dietary guidelines [2] super healthy kids (shk) http://ww w.superh ealthykid s.com 204 120 3 274 660 dietitian other – focus on fruit and vegetable intake for children yes – us dietary guidelines [27] quirky cooking https://w ww.quirk ycooking. com.au/ 198 340 267 268 other real food; paleo, dairy-free, gluten-free, other -gaps diet no weight watchers aunz (weight watchers) https://w ww.weig htwatcher s.com/au/ 127 322 160 867 weight loss program calorie-count yes – australian dietary guidelines [2] rebel dietitian (rebel) https://re beldietitia n.us 104 132 1 948 694 dietitian real food, vegan, raw. no *note: the iqs website was taken down may 31, 2018, however the sarah wilson website and blog as well as ebooks are still available online. step 2 – assessment of the dietary advice and alignment with aghe table 2 indicates alignment or deviation/ contradiction between advice of popular pages and the aghe on what to eat or limit. of the nine pages and associated websites reviewed, two (12 wbt, food trends and popular nutrition advice online – implications for public health 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi weight watchers) aligned with all nine aghe categories. three (rebel dietitian, healthy mummy and shk) aligned with 8 aghe categories; and one aligned with the aghe on 5 (quirky cooking), 4 (jamie oliver), 3 (pete evans), and 2 (iqs) categories. two (jamie oliver, shk) deviated from the guidelines only due to insistence on organic versions. iqs deviated from the guidelines by an inappropriate focus on fructose elimination. table 2 – alignment of popular online dietary advice with the australian guide to healthy eating page vegetables fruit legumes grains lean meat dairy/ altern ative fat sugar salt michelle bridges 12 week body transformation (12wbt) √ √ √ √ √ √ √ √ √ jamie oliver x* x* √ √ x* x* x* √ √ chef pete evans (pete evans) √ x x x √ x x √ x i quit sugar (iqs) √ x x x x √ x x** x the healthy mummy (healthy mummy) √ √ √ √ √ √ x √ √ super healthy kids (shk) √ √ √ √ x √ √ √ √ quirky cooking √ √ √ √ x √ x x x weight watchers ausnz (weight watchers) √ √ √ √ √ √ √ √ √ rebel dietitian √ √ √ √ √ √ x √ √ √ -aligned with aghe.x-conflicting / contradictory to aghe * consumption advice aligns with aghe but stipulates organic versions as healthier. ** consumption advice aligns with aghe, but advice to eliminate fructose is not supported by evidence. table 3 provides the advice of popular online authors summarised by food groups. italics have been used where: 1. the advice is directly contradictory to aghe such as limiting fruit, dropping food groups, eating saturated fat; and 2. non-evidence-based advice that overstate the health benefits or harms of categories and sub-categories of food that deviates from government guidelines – for example food trends and popular nutrition advice online – implications for public health 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi eating organic food, choosing himalayan salt, replacing sugar with natural sugar or eliminating fructose. only two websites,12wbtand weight watchers, were fully consistent with recommendations in the aghe, across all food groups, fat, sugar and salt. jamie oliver was consistent on all nine aghe recommendations; however, the advice on fruits, vegetables, lean meat and dairy goes beyond the guidelines by stipulating organic versions of are healthier. similarly, the website of shk too aligned on all nine categories, but promotes organic meat. the aghe does not recommend organic varieties over conventionally grown foods, as there is no consistently proven nutritional advantage [15]. further, food standards australia and new zealand (fsanz) specify a maximum residual limit (mrl) for agricultural or veterinary chemical residue that is legally allowed for all food sold in australia [16] ensuring conventionally grown food is safe for consumption. thus, insisting on only organic versions as the healthier option may compromise attempts to increase fresh food consumption among all australians due to the additional costs and lesser availability of organic produce. the healthy mummy and rebel dietitian were aligned with aghe on all food groups, salt and sugar except in the promotion of saturated fats. pete evans, quirky cooking, and iqs presented the most contradictions with aghe, with advice including limiting fruit (pete evans, iqs) to going dairy-free (pete evans and quirky cooking) or gluten-free or dropping grains completely. all three promoted “real food” versions such as grassfed meat, pastured and free-range poultry and eggs, wild caught fish and espoused consuming fullfat dairy, and saturated fats, including coconut oil. although these websites limited sugar, iqs advice claimed only fructose elimination (component of fruits) was more important than addressing total added sugars. these websites also promoted himalayan, pink or celtic varieties of salt. discussion and conclusion our assessment revealed that the most popular nutrition information pages on facebook are often hosted by celebrities, followed by dietitians, weight loss programs or other persons. only two were fully aligned with government guidelines, while the rest deviated from aghe in some way – either through direct contradiction on one or more categories, misinformation, or through overlyrestrictive recommendations, exposing health information seekers to conflicting nutrition information. while some public health goals such as consumption of vegetables and avoiding ‘junk’ foods are prominent, the balance of the advice does not align closely with aghe. the “real food” trend characterized by organic food choices is very popular online within our study sample. public health organisations promoting aghe on facebook are few and have negligible likes compared with popular pages. proactive efforts are needed by public health organizations in partnership with social media and social marketing experts to leverage facebook to promote dietary guidelines. partnering with celebrities may be a vehicle to boost reach of evidence-based nutrition information and countering misinformation, by improving quality and consistency of nutrition messaging. food trends and popular nutrition advice online – implications for public health 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi table 3 – diet and nutrition advice of popular facebook pages / websites page vegetables fruit legumes grains lean meat, poultry, fish, eggs dairy/alternat ive fats sugar salt michelle bridges 12 week body transformation (12wbt) eat all vegetables. choose nonstarchy vegetables. 5 serves a day. eat fruit. choose seasonal, variety. avoid dried fruit and juice eat legumes eat wholemeal or whole grain. eat meat, poultry, fish, eggs. eat lean, grilled. 1 serve a day. eat dairy or alternatives. choose low-fat option. two serves a day limit butter/margarin e use unsaturated fat options. avoid deepfrying eliminate soft drinks. eliminate salt. chose lowsodium foods jamie oliver eat vegetables. choose variety of colours, seasonal, organic. eat fruit. choose variety of colours, seasonal, organic. eat beans. regularly. eat wholemeal or whole grain. chose complex carbohydrates. eat. quality over quantity. choose organic, freerange or higher-welfare, responsibly sourced. eat dairy. choose low fat, reduced saturated fat and reduced sugar. choose organic. eat unsaturated fat. coconut oil (saturated fat) may be exception. avoid added sugar. reduce salt. chef pete evans (pete evans) eat vegetables. choose fibrous (non-starchy) vegetables and greens. choose cultured and fermented vegetables. limit fruit avoid legumes avoid grains eat meat, poultry, fish and eggs. choose grass-fed meat, pastured and free-range poultry and eggs, wild caught fish avoid dairy eliminate vegetable oils. use olive or nut oil unheated. use natural fats such as duck fat, tallow, pastured lard. use coconut oil. eliminate refined sugar. choose himalayan and celtic sea salt i quit sugar (iqs) eat vegetables. choose variety of colours. plenty. maximise green vegetables. limit fruit. avoid dried fruit and juice avoid legumes. if eaten then soak / activate. limit carbohydrates. choose glutenfree. use fermented, sprouted, wholegrain. eat meat, poultry, eggs and fish. choose sustainable, organic, grassfed, grain-fed (organic grain), free range eat full fat dairy. eliminate low-fat products. eat saturated fats. avoid polyunsaturated fatty acids. avoid omega 3 supplements. get omegas from food sources. eliminate transfats. eliminate fructose. eat glucose, maltose and lactose in moderation. eliminate refined tablesalt. choose pink salt, whole food sources of salt. food trends and popular nutrition advice online – implications for public health 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi the healthy mummy (healthy mummy) eat vegetables eat fruit eat legumes and beans. use dried or canned varieties. eat wholegrains. try quinoa a gluten-free grain. eat. choose less calorie, lean, low-fat, high protein like turkey. avoid high sugar dairy. eat saturated fats, eat coconut oil avoid processed fats eliminate soft drinks reduced salt or no salt super healthy kids (shk) eat a variety of fresh, frozen, canned, dried, raw or cooked vegetables eat fresh, frozen, canned. limit fruit juice. or dried fruit. eat legumes eat wholegrain eat organic or hormone free eat low fat/fat free dairy avoid trans fat salt – not too much quirky cooking eat vegetables. eat organic. eat fruits. avoid fruits affected by pesticides. eat organic. eat legumes. soaked. eat grain free and/or gluten free/ low gluten pesticide free, soaked, sprouted, fermented grains eat grass fed, free-range, organic meat avoid dairy, except for butter/ghee eat saturated fats. avoid polyunsaturated vegetable oils. choose macadamia oil, tallow, duck fat, or ghee. chose fats with high smoke point. avoid refined sugar. replace with more natural sugars. choose himalayan or celtic salt weight watchers ausnz (weight watchers) eat vegetables. choose variety and in season eat fruit. variety and in season eat pulses as a meat replacement eat wholegrains eat lean meats eat low fat dairy eat vegetable, nut and seed oils limit sugar limit sugar rebel dietitian eat a variety of vegetables eat a variety of fruit. naturally dried fruit is ok eat legumes. minimally processed. soaked. eat wholegrains recommend soaking. avoid processed grains limit meat and processed meat. if eaten, choose organic. avoid fish and shellfish products toxic contaminants. limit dairy avoid animal sources of saturated fat. use unrefined and coldpressed oils at room temperature sparingly use. saturated plantbased fat for cooking avoid added sugars, avoid processed sugars iodised salt note: italicised text indicate non-evidence-based advice or those that deviate from aghe. food trends and popular nutrition advice online – implications for public health 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi although the sources we reviewed were consistent with aghe on increasing vegetable consumption and limiting sugar and ‘junk foods,’ food fads and misinformation were otherwise common. promotion of ‘niche’ dietary patterns such as gluten-free and diary-free are concerning because they are promoted to everybody, and not limited only to special patient groups for whom they may be necessary. equally, although some health benefits have been reported in small samples and for specific health conditions for the paleo diet [17] there is no evidence around its long-term safety and efficacy within the general population. paleo pages’ advice to the general population to eat saturated fat, exclude grains and legumes, and exclude dairy not only directly contradict official dietary guidelines, but can potentially aggravate the problem of australians not eating minimum recommended serves of several food groups [3]. while the government guidelines are evidence-based and promote balanced diets drawing on all food groups, diet trends such as promotion of coconut oil and pink salt, or arousing public fear of fructose, deviate from guidelines [18]. such emphasis to consume or eliminate particular foods or food components, and the trend of dropping entire food groups, create fertile ground for contradictory nutrition messaging and may lead people to doubt dietary guidelines and health recommendations in general [5]. the “real food” trend is predominant online and promoted across popular facebook pages. while there are no formal definitions for “real food,” the pages in our study broadly refer to “real food” as organic and responsibly sourced whole foods, and exclusion of highly processed foods. sustainability and sources of food appear to be important to facebook followers of popular nutrition pages. this is consistent with findings from an earlier study on food beliefs and perceptions of australians [18]. public health organizations can learn much from popular pages on fostering public engagement by linking discussions on healthy eating with other values important to australians, such as environmental sustainability and animal welfare. the lack of facebook pages dedicated to the promotion of government dietary guidelines amidst various popular pages was particularly striking. for example, pages of nutrition australia [19] and daa [20] had less than 25,000 likes and seemed to be followed by professional nutritionists and dietitians, rather than by the general public. we also found a single post on australian dietary guidelines on the page of department of health [21] which had less than 75,000 likes. an earlier study looking for facebook presence of public health organizations also found only one nutritionrelated page that of nutrition australia [22]. it appears that current online dissemination of evidence-based dietary guidelines does not have a large reach in the general population and lacks a strong enough presence on facebook to counter misinformation propagated by popular pages. our study finds a clear opportunity for public health organizations and health communicators to leverage facebook to promote healthy eating guidelines. for example, public health organizations can create facebook pages dedicated to promoting healthy eating, by disseminating evidencebased guidelines, and countering misinformation. content should be tailored in light of popular online nutrition themes and broader food choice issues identified in this study and leveraged along with effective facebook strategies identified in existing research [22]. building a network and reaching audiences on facebook is not easy. celebrity-power, on the other hand, allows their pages to have vast following and social media influence. positive influences that celebrities can have on public health has been highlighted before [23] and this is exemplified by popular and government response to jamie oliver’s ministry of food [24] and the more recent sugar smart uk [25] campaigns. we recommend public health organizations explore partnerships with celebrities in food trends and popular nutrition advice online – implications for public health 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi promoting accurate healthy eating guidelines. we believe this can vastly improve reach and impact of nutrition and diet communication. study limitations as facebook is the single largest social media platform, we used number of “likes” to extrapolate nutrition websites that are popular in australia. it is possible that some popular dietary trends not promoted on facebook or did not have more than 100,000 facebook likes were not included in our study (for example intermittent fasting and ketogenic diets). we did not analyse data across all online and social platforms or quantify repetitions of themes within these platforms. nonetheless, while not definitive, the approach taken may be a reasonable indicator of the predominant nutrition and food choice related themes trending, to inform public health agencies in approaching nutrition communication efforts. as a next step, research examining effectiveness of a dedicated evidencebased nutrition facebook page, and countering misinformation is recommended. celebrity partnership may be explored for such a page along with assessment of reach and impact. conclusion our study shows that that the popular diet and nutrition information websites are not fully aligned with evidence-based guidelines. even those popular pages that reference government guidelines do so with their own interpretation and perceptions, which can create confusion among online health information seekers. a concentrated effort is required to promote healthy eating guidelines to the general public and counter the misinformation easily accessible online. such online efforts may be well served by beginning with facebook given its near universal popularity and reach. references 1. nutrition | national health and medical research council [internet]. nhmrc.gov.au. 2018 [internet]. 2017 [cited 7 september 2017]. available from: https://www.nhmrc.gov.au/healthtopics/nutrition. 2. nhmrc.gov.au. australian dietary guidelines (2013) | national health and medical research council [internet]. 2018 [cited 15 june 2015]. available from: https://www.nhmrc.gov.au/guidelines-publications/n55. 3. 4364.0.55.012 australian health survey: consumption of food groups from the australian dietary guidelines, 2011-12 [internet]. abs.gov.au. 2018 [cited 12 june 2018]. available from: http://www.abs.gov.au/ausstats/abs@.nsf/mf/4364.0.55.012. 4. boylan s, louie jcy, gill tp. 2012. consumer response to healthy eating, physical activity and weight‐related recommendations: a systematic review. obes rev. 13(7), 606-17. pubmed https://doi.org/10.1111/j.1467-789x.2012.00989.x 5. nagler rh. 2014. adverse outcomes associated with media exposure to contradictory nutrition messages. j health commun. 19(1), 24-40. pubmed https://doi.org/10.1080/10810730.2013.798384 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22404752&dopt=abstract https://doi.org/10.1111/j.1467-789x.2012.00989.x https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=24117281&dopt=abstract https://doi.org/10.1080/10810730.2013.798384 food trends and popular nutrition advice online – implications for public health 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi 6. goldberg jp, sliwa sa. 2011. communicating actionable nutrition messages: challenges and opportunities. proc nutr soc. 70(1), 26-37. pubmed https://doi.org/10.1017/s0029665110004714 7. vardeman je, aldoory l. 2008. a qualitative study of how women make meaning of contradictory media messages about the risks of eating fish. health commun. 23(3), 28291. pubmed https://doi.org/10.1080/10410230802056396 8. ward pr, henderson j, coveney j, meyer s. 2012. how do south australian consumers negotiate and respond to information in the media about food and nutrition?: the importance of risk, trust and uncertainty. j sociol (melb). 48(1), 23-41. https://doi.org/10.1177/1440783311407947 9. fox s. the social life of health information, 2011 [internet]. pew research center: internet, science & tech. 2011 [cited 9 november 2015]. available from: http://www.pewinternet.org/2011/05/12/the-social-life-of-health-information-2011/. 10. pew research center. internet, science & tech. online health search [internet]. 2006 [cited 9 november 2015]. available from: http://www.pewinternet.org/files/oldmedia/files/reports/2006/pip_online_health_2006.pdf.pdf. 11. pollard cm, pulker ce, meng x, kerr da, scott ja. 2015. who uses the internet as a source of nutrition and dietary information? an australian population perspective. j med internet res. 17(8), e209. pubmed https://doi.org/10.2196/jmir.4548 12. sensis social media report 2017. 2017 [cited 30 august 2017]. available from: https://www.sensis.com.au/asset/pdfdirectory/sensis-social-media-report-2017.pdf. 13. shaw rj, johnson cm. 2011. health information seeking and social media use on the internet among people with diabetes. online j public health inform. 3(1). pubmed https://doi.org/10.5210/ojphi.v3i1.3561 14. socialbakers.com. social media marketing, statistics & monitoring tools [internet]. 2017 [cited 7th september 2017]. available from: http://www.socialbakers.com/. 15. is organic food better for my health? – dietitians association of australia [internet]. daa.asn.au. 2018 [cited 15 june 2018]. available from: https://daa.asn.au/smart-eating-foryou/smart-eating-fast-facts/healthy-eating/is-organic-food-better-for-my-health/. 16. food standards australia new zealand [internet]. 2018 [cited 24 july 2018]. available from: http://www.foodstandards.gov.au/consumer/chemicals/maxresidue/pages/default.aspx. 17. manheimer ew, van zuuren ej, fedorowicz z, pijl h. 2015. paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis. am j clin nutr. 102(4), 922-32. pubmed https://doi.org/10.3945/ajcn.115.113613 18. dietitians association of australia – hot topics [internet]. daa.asn.au. 2018 [cited 24 may 2018]. available from: https://daa.asn.au/voice-of-daa/hot-topics/. https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21208498&dopt=abstract https://doi.org/10.1017/s0029665110004714 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18569057&dopt=abstract https://doi.org/10.1080/10410230802056396 https://doi.org/10.1177/1440783311407947 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26310192&dopt=abstract https://doi.org/10.2196/jmir.4548 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23569602&dopt=abstract https://doi.org/10.5210/ojphi.v3i1.3561 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26269362&dopt=abstract https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=26269362&dopt=abstract https://doi.org/10.3945/ajcn.115.113613 food trends and popular nutrition advice online – implications for public health 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi 19. nutrition australia [internet]. facebook.com. 2018 [cited 25 june 2017]. available from: https://www.facebook.com/nutritionaustralia/. 20. dietitians association of australia [internet]. facebook.com. 2018 [cited 25 june 2017]. available from: https://www.facebook.com/dietitiansassociation/?ref=br_rs. 21. australian department of health [internet]. facebook.com. 2018 [cited 25 june 2017]. available from: https://www.facebook.com/healthgovau/. 22. kite j, foley bc, grunseit ac, freeman b. 2016. please like me: facebook and public health communication. plos one. 11(9), e0162765. pubmed https://doi.org/10.1371/journal.pone.0162765 23. chapman s. 2012. does celebrity involvement in public health campaigns deliver long term benefit? yes. bmj: british medical journal. 345, e6364. pubmed https://doi.org/10.1136/bmj.e6364 24. the good foundation [internet]. jamie's ministry of food. 2018 [cited 13 may 2018]. available from: https://www.jamiesministryoffood.com.au/the-good-foundation. 25. welcome | sugar smart uk [internet]. sugarsmartuk.org. 2018 [cited 13 may 2018]. available from: https://www.sugarsmartuk.org/ 26. the eatwell guide [internet]. gov.uk. 2018 [cited 19 april 2018]. available from: https://www.gov.uk/government/publications/the-eatwell-guide. 27. 2015–2020 dietary guidelines for americans health.gov [internet]. health.gov. 2018 [cited 19 april 2018]. available from: https://health.gov/dietaryguidelines/2015/. appendix supplementary material content analysis examples of coding of popular diet advice the examples below show how popular diet advice summarised in table 3 were derived. of each piece of content, three questions were asked: 1. do the authors recommend eating, limiting, and/or avoiding food groups? 2. do authors specify items to eat, limit, and/or avoid within the food groups? 3. do authors prescribe the selection of food in any manner (for example: organic, grassfed, pesticide-free, non-gmo, canned, frozen), or cooking technique (for example soaking, fermenting). example 1: fruit recommendation url: https://www.12wbt.com/blog/nutrition/can-really-much-fruit/ https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=27632172&dopt=abstract https://doi.org/10.1371/journal.pone.0162765 https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23015036&dopt=abstract https://doi.org/10.1136/bmj.e6364 food trends and popular nutrition advice online – implications for public health 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 10(2):e213, 2018 ojphi content: "how much fruit is enough? finding the ‘juicy’ sweet spot is important for overall nutrition balance, but we need to keep in mind our energy requirements and our food intake for a whole day. aim to choose fruit in season and mix up your variety (berries, citrus, tropical, etc.) to not only get fabulous flavour and nutrient hits, but to keep costs down and support the local produce! it is important to note that it is very easy to overeat dried fruit and fruit juices – both of which can increase the risk of tooth cavities due to their acidity (juice) and ability to stick to teeth (dried fruit). so keep these in check!" described as: eat fruit. avoid dried fruit and fruit juice, chose seasonal and variety. example 2: fat recommendation url: https://www.quirkycooking.com.au/substitutes-recipe-conversions/dairy/ content: “in addition to the specific benefits of omega 3s found in natural foods, there is a massive benefit to gut health that is to be gained by switching from polyunsaturated vegetable oils to animal fats.” “i now mostly use macadamia oil, tallow, duck fat, or ghee for shallow frying, as they have high smoke points. i used to use coconut oil, but you need to be very careful with frying with coconut oil as the smoke point is only 170c.” described as: eat saturated fats; avoid polyunsaturated vegetable oils; choose macadamia oil, tallow, duck fat, or ghee; choose fats with high smoke point. food trends and popular nutrition advice online – implications for public health abstract introduction methods study design and approach sample selection data collection step 1 – description of popular facebook pages step 2 – assessment of the dietary advice and alignment with aghe results step 1 – description of popular facebook pages step 2 – assessment of the dietary advice and alignment with aghe discussion and conclusion study limitations conclusion references appendix supplementary material content analysis examples of coding of popular diet advice editorial: ojphi vol 5, no 2 (2013) 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi editorial: ojphi vol 5, no 2 (2013) welcome to the current issue of the online journal of public health informatics. at this stage i will like to take the opportunity to thank the reviewers who have been doing a wonderful job in providing prompt reviews of the articles assigned to them. we have achieved our status as a pubmed indexed, peer-reviewed journal mainly because you have taken this ‘labor of love’ assignment quite seriously. we plan to give graduate students an opportunity to submit summaries of their capstone reports and dissertations for publication as working papers in future issues of the journal. authors will also be invited to deliver webinars on their articles to the public health informatics community. these webinars and their accompanying discussions will be recorded and archived. students will be encouraged to attend these webinars. it is fair to say that, through the support of the reviewers and readers we have succeeded in positioning this journal as the sole portal for disseminating public health informatics research findings. the capability to exchange patient-specific health data among autonomous healthcare entities is at the core of successful implementation of health information exchanges. this capability is also important for patient treatment, public health services delivery, and research. wu xu et al. describe efforts to create a statewide master person index in utah to uniquely identify each individual receiving healthcare or public health services. exchanging personally identifiable information across enterprises for healthcare identity resolution requires new models for data sharing and a complex policy framework to mitigate risks to participants and ensure cooperative success. the authors developed a focus area maturity model to guide the complex process of developing a functional statewide master person index (smpi) among diverse, autonomous partners. the proposed framework provides an orderly path to address interdependences that can guide the complex process of developing a functional smpi, avoiding conflicts between policy and technology that may lead to nonfunctional implementations. immunization registries have been shown to increase vaccine coverage rates and reduce duplicate immunizations. in order to achieve meaningful use the health information technology for economic and clinical health (hitech) act of 2009 encourages providers to submit electronic immunization data to regional or statewide immunization information systems. at present, many providers have established unidirectional interoperability for uploading emr immunization data to designated registries. it is recognized that bidirectional interoperability is preferable because it allows immunization data to be transmitted directly to vendor emrs. integration is, however, expensive and difficult to achieve. lindsay a. stevens, jonathan p. palma, et.al develop and test the feasibility of visually integrating external registries into vendor emr systems. the study shows that this procedure meets providers’ need for relevant data, increases reporting of immunizations, improves provider satisfaction, and avoids the increased costs of bidirectional data integration. approximately 300,000 individuals die from out-of-hospital cardiac arrest (ohca) annually in the united states. it has been observed that there is a wide disparity in the ohca survival rates between cities in usa. hugh semple et al. present results from an on-going project to develop user-friendly, interactive web mapping application that allows public health professionals and the general public to visualize the geographic patterns of cardiac arrest rates, bystander cpr rates, and target specific locations for public health services delivery. participants in a preliminary editorial: ojphi vol 5, no 2 (2013) 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi evaluation felt that the web mapping application was a useful, user-friendly geovisualization tool. it is expected that this project will encourage the development of public health web mapping applications that are centered on interactive maps, summary statistics, and the use of social media technology. various social and institutional issues present challenges in the implementation of school-based sexual health education in developing countries. angella musiimenta of mbarara university of science and technology, uganda, presents the results of a study aimed at identifying the factors responsible for successful implementation of technology-aided sexual health education in two ugandan schools. the results indicate that, rather than focusing exclusively on technology, program administrators should create social, institutional, and religious climate that is more supportive of school-based computer-assisted education. health services and public health researchers increasingly rely on search engines to identify relevant articles. the reliability of these search engines is very necessary if one is to avoid costly mistakes. google scholar (gs) is widely-recognized as an excellent source of grey literature in biomedicine. it is a useful tool to help researchers quickly locate relevant papers from billions of pages across the web. research by dean guistini et al. demonstrates that gs is not flexible, precise or indexed enough to be used alone for systematic reviews. the authors show that google search’s ‘keyword search' capability, allied to google’s pagerank, is a poor replacement for controlled vocabulary searching and its interface does not provide enough flexibility to accommodate search filters by discipline, such as ‘health and medicine’. the authors recommend that google search developers should provide full details about its database coverage and improve its interface search capabilities (e.g., indexing, semantic search filters, stored searching, etc.) in order to satisfy the demands of thorough, replicable searches as required by systematic reviews for health services and public health research. thomas g. savel et al. describe the development of partial thromboplastin time (ptt) advisor, a cdc-supported initiative to develop a mobile clinical laboratory decision support application. this is among the first of a handful of ios-based applications funded by cdc. the application offers clinicians a resource to quickly select the appropriate follow-up tests to evaluate patients with prolonged ptt and a normal prothrombin laboratory result. the authors address some of the challenges involved in the development and deployment of the application. the free mobile ptt advisor app was approved by apple and published in their itunes app store. lessons learned from this project will assist other mobile health/public health application developers understand and overcome some of the challenges involved in such projects. the determination of priorities is an essential component of community health status assessment. priority setting enables the rational allocation of limited resources among competing programs. james studnicki et al. utilized the analytical capabilities of online analytic processing( olap) interface to create a community health status prioritizing system which, among other attributes, is capable of ranking different types of health status outcomes and also provides flexibility in the weighting of the evaluation criteria. the authors demonstrate that rankings of community health outcomes based on olap provide sufficient information for priority setting compared to previous methods based on a static set of criteria with fixed weighting factors. editorial: ojphi vol 5, no 2 (2013) 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi the adoption of certified electronic health records and the implementation of health information exchanges are expected to facilitate the sharing of patients’ health records by authorized providers. records can thus follow patients resulting in reduced delays, duplications, errors, quality improvements and lower costs. ultimately, the idea is to enable the patient to control access to their own data. access to care records is currently often difficult or impossible in cases where records contain personal identifiers; they have to be secured behind services that greatly impede ready access. existing access control infrastructures are proprietary, further making it impossible to retrieve patient records electronically on demand from a workstation that is not part of the record keeper’s network. existing solutions to the data portability problem have raised issues as to whether the public would have confidence that their personal records were safe, secure and private, especially when cloud-based or controlled by third party commercial service providers such as microsoftvault, googlehealth, etc. roderick neame outlines a platform-independent method that avoids most of the issues raised by existing record portability solutions and ensures continuum of care for patients such that their care records follow them wherever they go. in order for such a methodology to be implemented successfully the author acknowledges that it is necessary to have an agreement on the record data types and sub-types, their associated xml tags, as well as develop a browser add-on that can import and display flexibly the xml marked-up records. these conditions are not difficult to achieve with existing technologies. research shows that the incidence of healthcareassociated infections (hais) has increased significantly in the past 20 years in usa. the number of patients who suffer from hais annually in usa is estimated to be approximately 2 million, with about 100,000 deaths annually, ranking hai among the leading causes of death in us acute-care hospitals. the federal government has mandated hospitals to publically report hai rates in order to increase transparency and trust between hospitals and consumers, and to disseminate best practices. however, there is limited guidance in the medical and public health literature related to public reporting of health careassociated infections data. yair rajwan et al. demonstrate that visual communication can provide effective evidence-based information to consumers for decision making and to practitioners for providing patient safety outcomes and processes. the prevention of hospital readmissions improves the quality of individual care as well as population health status. under the hospital readmissions reduction program hospitals must reduce readmissions in order to avoid being penalized financially. accurately predicting the risks of readmissions is a requirement for improving the transition of care process during and postdischarge. the use of administrative claims data is a major limitation of most risk prediction models. shahid choudhry, jing li et al. utilized electronic health records data and a mixedmethod risk prediction model to evaluate post-discharge risk factors. the model demonstrated reasonable fit in heterogeneous populations. given the range of variables that contribute to readmission risks it is necessary to include variables from electronic health records in developing hospital readmission risks. noncomunicable diseases ( ncd) currently constitute the leading causes of deaths in all regions of the world except africa. the largest increase in ncd deaths by 2020 is projected for africa, eastern mediterranean and south-east asian countries. stephan kohler reviews web portals that provide information for reducing preventable lifestyle-related risk factors associated with ncds. editorial: ojphi vol 5, no 2 (2013) 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol. 5, no. 2, 2013 ojphi the author also discusses an open access web portal initiated by two german states for ncd prevention and health promotion activities. this issue includes two commentaries. the first commentary addresses the sustainability of public health surveillance systems. in recent years the world has witnessed disease outbreaks and epidemics resulting in loss of lives and significant economic costs. for example, the global severe acute respiratory syndrome of 2002-2003 resulted in a financial cost of $40 billion to $54 billion dollars while the anthrax attack in us in 2001 resulted in financial cost of 320 million dollars, 22 cases, including 5 deaths. the significant health impacts and economic costs of disease outbreaks illustrate the critical importance of effective public health surveillance and rapid response. in order to respond effectively to the growing threats to population health, public health surveillance systems must be built on a stable infrastructure of core workforce competencies, information systems, and organizational capacity, and must be supported by enterprise-based funding. nabila mirza, terra reynolds et al. present the recommendations of the sustainable surveillance workgroup convened by the international society for disease surveillance to identify strategies for building, strengthening, and maintaining surveillance systems. a disparity currently exists between the accuracy of icd-9 admission coding and discharge coding with some error rates as high as seventy percent. it is envisioned that the transition to icd-10 coding could increase this disparity. in the second commentary, christopher bell, arash jalali, et.al. propose a decision support technology, the icd-10 anatomographer, which could assist emergency department physicians working in busy trauma units in finding accurate icd10 codes efficiently, thereby improving quality of care. best regards edward mensah, phd editor-in-chief online journal of public health informatics 1603 west taylor street, room 759 chicago, illinois, 60612 email:dehasnem@uic.edu office: 312-996-3001 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts towards linking anonymous authorship in casual sexual encounter ads jason a. fries*1, alberto m. segre1 and philip m. polgreen2 1computer science, the university of iowa, iowa city, ia, usa; 2the university of iowa department of internal medicine, iowa city, ia, usa objective this paper constructs an authorship-linked collection or corpus of anonymous, sex-seeking ads found on the classifieds website craigslist. this corpus is then used to validate an authorship attribution approach based on identifying near duplicate text in ad clusters, providing insight into how often anonymous individuals post sexseeking ads and where they meet for encounters. introduction the increasing use of the internet to arrange sexual encounters presents challenges to public health agencies formulating std interventions, particularly in the context of anonymous encounters. these encounters complicate or break traditional interventions. in previous work [1], we examined a corpus of anonymous personal ads seeking sexual encounters from the classifieds website craigslist and presented a way of linking multiple ads posted across time to a single author. the key observation of our approach is that some ads are simply reposts of older ads, often updated with only minor textual changes. under the presumption that these ads, when not spam, originate from the same author, we can use efficient near-duplicate detection techniques to cluster ads within some threshold similarity. linking ads in this way allows us to preserve the anonymity of authors while still extracting useful information on the frequency with which authors post ads, as well as the geographic regions in which they seek encounters. while this process detects many clusters, the lack of a true corpus of authorship-linked ads makes it difficult to validate and tune the parameters of our system. fortunately, many ad authors provide an obfuscated telephone number in ad text (e.g., 867-5309 becomes 8sixseven5three oh nine) to bypass craigslist filters, which prohibit including phone numbers in personal ads. by matching phone numbers of this type across all ads, we can create a corpus of ad clusters known to be written by a single author. this authorship corpus can then be used to evaluate and tune our existing near-duplicate detection system, and in the future identify features for more robust authorship attribution techniques. methods from 7-1-2009 until 7-1-2011, rss feeds were collected daily for 8 personal ad categories from 414 sites across the united states, for a total of 67 million ads. to create an anonymous, author-linked corpus, we used a regular expression to identify obfuscated phone numbers in ad text. we measure the ability of near-duplicate detection to link clusters in two ways: 1) detecting all ads in a cluster; and 2) correctly detecting a subset of ads within a single cluster. ads incorrectly assigned to more than 1 cluster are considered false positives. all results are reported in terms of precision, recall, and f-scores (common information retrieval metrics) across cluster size, expressed as number of ads. results 652,014 ads contained phone numbers, producing a total of 46,079 authorship-linked ad clusters. for detecting all ads within a cluster, precision ranged from 0.05 to 0.0 and recall from 0.02 to 0.0 for all cluster sizes. for detecting partial clusters, see figure 1. conclusions we find that near-duplicate detection alone is insufficient to detect all ads within a cluster. however, we do find that the process can, with high precision and low recall, detect a subset of ads associated with a single author. this follows the intuition that an author’s total set of ads is itself comprised of multiple self-similar subsets. while a near-duplicate detection approach can correctly identify subsets of ads linked to a single author, this process alone cannot attribute multiple clusters to a single author. future work will explore leveraging additional linguistic features to improve author attribution. (top) evaluations for partial cluster detection using the near-duplicate identification approach to linking anonymous authorship in craigslist ads and (bottom) the distribution of ad cluster sizes. keywords surveillance; public health; stds; authorship attribution; computer science references [1] ja fries, am segre, pm polgreen .using online classified ads to identify the geographic footprints of anonymous, casual sex-seeking individuals. ase/ieee international conference on social computing 2012. *jason a. fries e-mail: jason-fries@uiowa.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e164, 2013 ojphi-06-e21.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 159 (page number not for citation purposes) isds 2013 conference abstracts capacity and needs assessment for establishing a syndromic surveillance system in rural china: a mixed study tao tao*1, qi zhao1, huijian cheng2, weirong yan3, 4, hengjin dong5, 6 and biao xu1 1school of public health, fudan university, shanghai, china; 2jiangxi provincial center for disease control and prevention, nanchang, china; 3division of global health (ihcar), department of public health sciences, karolinska institutet, stockholm, sweden; 4department of epidemiology and biostatistics, school of public health, tongji medical college, huazhong university of science and technology, wuhan, china; 5institute of public health, heidelberg university, heidelberg, germany; 6center for health policy studies, school of public health, zhejiang university school of medicine, hangzhou, china � �� �� �� � � �� �� �� � objective �������� �� ��������� ����������������������� ����������� ��������� ����������� ������������ ���������������� �� ���� ����������������� ��� ����������������� � ����������������� �� � ����� ����� � �� ���� ��������������������������� ���� ������������ �������������������� � �� � ����� ��� ������ ������ ����!������������"������������������ ���� �������� # introduction ��������� ������������ � ���������������� ��������������� �������� ���������������������� ��� �� �����"��� ��������"������ ������������ ���� ������������������������ #�$��������� ��"�� ������ ��������� ������������ � ������%������ �������� ���������������������������� � ���������������������������"����������������� ��� �� ������� ��� "���� ������������� ������������������ #�&������"��'��������(����) � *� �&������� �+������������ ��������� ������������ � ���������� ,� �-��� �������������"��"������������������������� �� ���.� ����� �� ��������� � �������������/����.��+������������ ���# methods 0��� ������ ������� � ��� /����.�� +�������� �1���.��� ������� ���� &���.������������� ����� ��� �� � ������ ����"��������������� ������ � ���� ����� ����� ��� #���� �%����������������%����������� ��� �� �����������������������.������� � � ����#�&�� ���������������� �������"� ���%�� ���������� ���������������� ���� ��������������� �� � ������� ������������� � ��� ���� ���� ������ ������������������� �� ����� ������������� ��������� �������� ��"� ���� �������� ��� ������ ������������������������� �"����������������������������� � ������������ ���������������� #�0 �������� ��������� �� ��� ��&23 ������ ����� ��������� �������������������%�� ���������� ����������������������� ������ ���� ���� �� ��� ������� ���� ����� � ���� ���� ����� �� � ����"������ ���������������������������������� �� �������������������� � �� ������������ � ���# results 0 �������������������� ���� ����������������� ������� �������������� � ������������ �� � �����" ������ �������������������� � ���������� "��� ����������������� � �������������� ����� ������ �� ������� ������ � ���#������� ����� ��� � ��������������� ���� � ����������� �������� � ������ ������ ������� ��������� ������� ��������� �������� ���� ��� �� ���������������������������"��"������� ������� �� ������ � ������ ���� ��������� ��� �� ������������� ��������������� #�4� ��� � ���� ������������� ������ ������ ������ ��� ��� ����������� ����� � ������������������ ������������"�������������� � �������������� ���� � ���������������� �����"������������ ����56#78����&���.���������� ����79#58����1���.�������������� �������� ����� ���������������� ������������� �� � ������ � ����#�:������������&23 ������������� ������������� ���������������� ��� ����� ����������������� ���������� ��������������� �� ����������� ��"���� ��� ������������ ��������� ������������������� �� � ���#� ��������������� ������������ ������ �� ���������� � �������� ���� ���� ��������������� ��� ��������������� ������������������� � �����" ������ ������������������������� ����� � ����� �� � ������� �������������������� � ������������� ����� ���� ���������������� �������������� #����������������������������������� ������ � ������������������� � ������������������� ������ ���"������������ ��������������� ��������� ������������ � ��������� ����������� ��������� ������������������� ������������ ����������������# conclusions 0 ���.� ���������� �������� ������� ����� ����� ������� ����� ���� ��������� ���� ��������������������� �� ���������������� �������"�� �����!�������� ��"�� ����� ��� �� ��������� ������������ � ���#� $�������������������" ����� ���������� ��������������������������������� �����%�����������������������"������������������ �� ��������������� � � �����"�����#�0����������������������� ��%�� ����������� ��������������� ������������ � ���������� �� ��������������������� ��� �� ���������� ������������������������#�'���������������������� ��� � �����"����� ������������������ �� ��������������������� �� � ��������� ����� �� ���������������������� �� �%������� ����������������# keywords ��������� �����������;���������;��������������� acknowledgments 0 � � ������� ��������"��'��������(����) � ����� �&������� �+��� ��������<&+*=6>>*�6>95?�<&+*=6>>*�6>99?��������������������������#� <6@9a>>?# *tao tao e-mail: ttsuper2000@hotmail.com� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e21, 2014 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a health department’s collaborative model for disease surveillance capacity building ikechi konkwo*1, 2, robert g. harmon1, william c. livingood2, 1, thomas bryantiii1 and saad zaheer1 1institute for public health informatics and research, duval county health dept, jacksonville, fl, usa; 2center for health equity and research university of florida/shands medical center, jacksonville, fl, usa objective highlight one academic health department’s unique approach to optimizing collaborative opportunities for capacity development and document the implications for chronic disease surveillance and population health. introduction public health departments are increasingly called upon to be innovative in quality service delivery under a dwindling resource climate as highlighted in several publications of the institute of medicine. collaboration with other entities in the delivery of core public health services has emerged as a recurring theme. one model of this collaboration is an academic health department: a formal affiliation between a health professions school and a local health department. initially targeted at workforce development, this model of collaboration has since yielded dividends in other core public health service areas including community assessment, program evaluation, community-based participatory research and data analysis. the duval county health department (dchd), florida, presents a unique community-centered model of the academic health department. prominence in local informatics infrastructure capacity building and hosting a cdc-cste applied public health informatics fellowship (aphif) in the institute for public health informatics and research (iphir) in partnership with the center for health equity research, university of florida & shands medical center are direct dividends of this collaborative model. methods we examined the collaborative efforts of the dchd and present the unique advantages these have brought in the areas of entrenched data-driven public health service culture, community assessments, program evaluation, community-based participatory research and health informatics projects. results advantages of the model include a data-driven culture with the balanced scorecard model in leadership and sub-departmental emphases on quality assurance in public health services. activities in iphir include data-driven approaches to program planning and grant developments, program evaluations, data analyses and impact assessments for the dchd and other community health stakeholders. reports developed by iphir have impacted policy formulation by highlighting the need for sub county level data differentiation to address health disparities. unique community-based mapping of duval county into health zones based on health risk factors correlating with health outcome measures have been published. other reports highlight chronic disease surveillance data and health scorecards in special populations. partnerships with regional higher institutions (university of florida, university of north florida and florida a&m university) increased public health service delivery and yielded rich communitybased participatory research opportunities. cutting edge participation in health it policy implementation led to the hosting of the fledgling community hie, the jacksonville health information network, as well as leadership in shaping the landscape of the state hie. this has immense implications for public health surveillance activities as chronic disease surveillance and public health service research take center stage under new healthcare payment models amidst increasing calls for quality assurance in public health services. dchd is currently hosting a cdc-funded fellowship in applied public health informatics. some of the projects materializing from the fellowship are the mapping of the current public health informatics profile of the dchd, a community based diabetes disease registry to aid population-based management and surveillance of diabetes, development of a proposal for a combined primary care/general preventive medicine residency in uf-shands medical center, jacksonville and mobilization of dchd healthcare providers for the roll-out of the state-built electronic medical records system (florida hms-ehr). conclusions academic health centers provide a model of collaboration that directly impacts on their success in delivering core public health services. disease surveillance is positively affected by the diverse community affiliations of an academic health department. the academic health department, as epitomized by dchd, is also better positioned to seize up-coming opportunities for local public health capacity building. keywords academic health departments; collaborative model; health informatics projects acknowledgments this study was supported in part by an appointment to the aphif program administered by cste and funded by the cdc cooperative agreement 3u38hm000414-04w1. *ikechi konkwo e-mail: ikechi_konkwo@doh.state.fl.us online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e46, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts can novel flu surveillance be conducted with limited resources? alan siniscalchi*1 and amanda schulte2 1state of ct dept of public health, hartford, ct, usa; 2international society for disease surveillance, boston, ma, usa objective this project was organized to facilitate discussions on whether successful novel flu surveillance can be conducted by jurisdictions with limited resources. the discussions will focus on gathering opinions regarding the best combination of surveillance systems to quickly and efficiently identify the presence of influenza a (h3n2)v and other novel influenza viruses in circulation. introduction the past decade has witnessed rapid development and implementation of numerous syndromic and other advanced surveillance systems to supplement traditional laboratory testing to identify the presence of novel influenza strains and track the impact on local populations. while much of the development and widespread implementation of these systems had been supported by public health preparedness funding, the loss of these monies has greatly constrained the ability of public health agencies to staff and maintain these systems. the periodic appearance of novel flu viruses, such as h3n2v, requires agencies to carefully choose which systems will provide the most cost-effective data to support their public health practice. methods this project will be facilitated by an experienced public health practitioner who has conducted surveillance for a variety of disease agents. additional public health practitioners are being recruited among members of the international society for disease surveillance (isds) public health practice committee (phpc) to contribute information on comparative approaches to cost effective surveillance. questions were selected for discussion and responses will be collected from influenza surveillance coordinators using a web-based survey tool managed by isds staff on behalf of the phpc. survey responses and subsequent recommendations will be presented at a phpc meeting. results initial questions selected for the survey tool and subsequent discussions include: what surveillance systems does your agency use for conducting influenza surveillance? which surveillance systems require trained and experienced public health and informatics staff to maintain? is your agency having difficulties in recruiting and retaining trained surveillance staff? has influenza a (h3n2)v been identified in your state or jurisdiction? does your agency have sufficient staff and other resources to be able to conduct targeted surveillance of novel influenza strains, such as identifying h3n2v cases associated with agricultural fairs or school surveillance for ili cases? which surveillance systems provide useful data for monitoring health impact during seasons with highly pathological influenza strains? which surveillance systems provide useful data for identifying the presence of novel influenza strains and conducting situational awareness? keywords situational awareness; influenza surveillance; h3n2v; resource limitations *alan siniscalchi e-mail: alan.siniscalchi@ct.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e169, 2013 editorial: ojphi vol 3, no 3 (2011) 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 editorial: ojphi vol 3, no 3 (2011) the centers of excellence in public health informatics: improving public health through innovation, collaboration, dissemination, and translation e. lee husting phd, mph 1 , kim gadsden-knowles ms, mph 1 1 division of informatics practice, policy, and coordination, public health informatics and technology program office, office of surveillance, epidemiology, and laboratory services, centers for disease control and prevention mesh key words: public health informatics, translational research the centers for disease control and prevention (cdc) centers of excellence in public health informatics (coe) program was established to advance the research and practice of public health informatics through several collaborative efforts (1). the coe program supports the development, translation, and dissemination of informatics knowledge; and provides expertise to public health professionals to maximize the potential of information systems to improve the health of the nation. the office of surveillance, epidemiology, and laboratory services (osels) funds the centers using a program project grant (p01) with each center leading two major research projects in collaboration with local public health partners (2). five original centers were funded in 2005 to serve as innovative incubators for transformational public health informatics research. a new competitive announcement was released in 2009 which resulted in awards to the four current centers: harvard pilgrim children’s hospital boston center of excellence, rocky mountain center for translational research in public health informatics, indiana university center of excellence in public health informatics, and university of pittsburgh center for advanced studies of informatics in public health. the current centers conduct research that leverages and builds upon the developmental accomplishments achieved by the original centers and supports cdc’s goals and strategic priorities. the centers’ research strengthens surveillance and epidemiology at cdc while supporting state, tribal, and local health departments to improve the public’s health (3). the centers activities address many of the critical priorities that cdc has determined to have large scale impact on health with known and effective strategies to include obesity, healthcareassociated infections and foodborne diseases (4). this special issue includes two articles from each of the four centers that highlight their recent contributions to the field of public health informatics. harvard pilgrim children’s hospital boston center of excellence harvard’s research focuses on uses of personally controlled electronic health records in the prevention, control, and reporting of chronic disease. klompas et al. describe the utility of an electronic medical record system to augment the behavioral risk factor surveillance system editorial: ojphi vol 3, no 3 (2011) 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 (brfss) and other traditional methods for diabetes surveillance. weitzman et al. present a novel approach to monitoring preventive and self-care practices for diabetes using an online social network. rocky mountain center for translational research in public health informatics utah’s research activities include implementing a visual analytic and decision support system to enhance community health assessment and public health surveillance and deploying new methods and models from computer science, social and behavioral sciences and other disciplines to represent knowledge and exchange information relevant to public health practice. staes et al. present an evaluation and analysis of reportable condition mapping tables relative to nationally defined reporting logic and recommend “using knowledge management tools to author, verify, improve, and authenticate logic, and continually incorporate improved logic that has been validated in clinical systems” (5). xu et al. describe how their framework for collaboration leads to successful translation of their research into public health practice. indiana university center of excellence in public health informatics indiana’s research includes developing adaptive turnaround document systems (computerinterpreted paper forms) to support newborn screening and immunization tracking and enhancing basic infrastructure capabilities to support public health. downs et al. review technical challenges in exchanging data between clinicians in the indiana health information exchange and the indiana state department of health. dixon et al. describe a process for developing a framework to continuously analyze public health data to improve data quality. university of pittsburgh center for advanced studies of informatics in public health pittsburgh’s research focuses on developing bayesian disease surveillance methods including case detection and outbreak detection and characterization and translating them into technologies for public health practice. wagner et al. present a probabilistic, decision-theoretic system for disease surveillance and control and use the example of influenza surveillance to describe how the software components transform data collected by the healthcare system into useful data for public health practice. tsui et al. demonstrate how a probabilistic case detection system uses emergency department dictated notes and laboratory results to compute the posterior probability of influenza and influenza-like illness. references 1. coe [internet].[cited 2011 dec 16]. available from: http://www.cdc.gov/osels/ph_informatics_technology/coe.html 2. coe p01 grant funding announcement [internet].[cited 2011 dec 16]. available from: http://www07.grants.gov/search/search.do?oppid=45247&mode=view 3. cdc fact sheet [internet].[cited 2011 dec 16]. available from: http://www.cdc.gov/about/resources/facts.htm 4. cdc winnable battles [internet].[cited 2011 dec 16]. available from: http://www.cdc.gov/winnablebattles/ 5. staes c, altamore r, han e, mottice s, rajeev d, bradshaw r. evaluation of knowledge resources for public health reporting logic: implications for knowledge authoring and management. online j public health inform. forthcoming 2011. http://www.cdc.gov/osels/ph_informatics_technology/coe.html http://www07.grants.gov/search/search.do?oppid=45247&mode=view http://www.cdc.gov/about/resources/facts.htm http://www.cdc.gov/winnablebattles/ editorial: ojphi vol 3, no 3 (2011) 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.3, no. 3, 2011 conflict of interest the authors declare that they have no real or apparent conflicts of interest. disclaimer the findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the centers for disease control and prevention. corresponding author e. lee husting phd, mph scientific program officer (extramural) division of informatics practice, policy, and coordination public health informatics and technology program office office of surveillance, epidemiology, and laboratory services centers for disease control and prevention 1600 clifton road, ms-76 atlanta, ga 30333 email: ehusting@cdc.gov mailto:ehusting@cdc.gov online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 1 online public health preparedness training programs: an evaluation of user experience with the technological environment priya nambisan, phd 1 1 university at albany, suny abstract objectives: several public health education programs and government agencies across the country have started offering virtual or online training programs in emergency preparedness for people who are likely to be involved in managing or responding to different types of emergency situations such as natural disasters, epidemics, bioterrorism, etc. while such online training programs are more convenient and cost-effective than traditional classroom-based programs, their success depends to a great extent on the underlying technological environment. specifically, in an online technological environment, different types of user experiences come in to play—users’ utilitarian or pragmatic experience, their fun or hedonic experience, their social experience, and most importantly, their usability experience—and these different user experiences critically shape the program outcomes, including course completion rates. this study adopts a multi-disciplinary approach and draws on theories in human computer interaction, distance learning theories, usability research, and online consumer behavior to evaluate users’ experience with the technological environment of an online emergency preparedness training program and discusses its implications for the design of effective online training programs. . methods: data was collected using a questionnaire from 377 subjects who had registered for and participated in online public health preparedness training courses offered by a large public university in the northeast. results: analysis of the data indicates that as predicted, participants had higher levels of pragmatic and usability experiences compared to their hedonic and sociability experiences. results also indicate that people who experienced higher levels of pragmatic, hedonic, sociability and usability experiences were more likely to complete the course(s) they registered for compared to those who reported lower levels. discussion: the study findings hold important implications for the design of effective online emergency preparedness training targeted at diverse audiences including the general public, health care and public health professionals, and emergency responders. strategies for improving participants’ pragmatic, hedonic, sociability and usability experiences are outlined. conclusion: there are ample opportunities to improve the pragmatic, hedonic, sociability and usability experiences of the target audience. this is critical to improve the participants’ learning and retention as well as the completion rates for the courses offered. online emergency preparedness online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 2 programs are likely to play a crucial role in preparing emergency responders at all levels in the future and their success has critical implications for public health informatics. introduction preparing the public health workforce to mitigate, respond to, and recover from natural and man made disasters is not a minor undertaking. both governmental and non governmental organizations have called on universities and other educational institutions to develop programs to efficiently and effectively train our public health workforce [1,2,3,4]. many educational institutions across the country have responded to this by developing and offering virtual or online programs that incorporate ‗canned courses‘—i.e. courses that do not require an instructor and instead allow students to download the materials and self-learn at their time of convenience [5]. the effectiveness of such online courses depends on delivering rich learning experiences for the students. however, unlike traditional classroom-based education, the online environment is not under the control of an instructor. students‘ learning experience in such online situations could be affected by not only the structure and content of the course but also the student interactions facilitated by the technology-based infrastructure and the usability of such infrastructure. thus, to measure the effectiveness of online courses, we need to go beyond the evaluation tools that are currently used to evaluate offline or classroom-based courses and use tools that provide a more holistic view of users‘ online learning experience. specifically, to understand and evaluate the learning experience in an online program, we need to draw on our understanding of people‘s behavior in online environments. prior studies in consumer psychology and human computer interaction offer an appropriate foundation for this. research in consumer psychology indicate that experience has two primary dimensions—a utilitarian (or cognitive) dimension and a hedonic (or affective) dimension [6,7,8,9,10]. however, in an online environment, factors that are either related to the technology itself or to the interactions of the people with the technology could also shape such experience. prior studies in the area of human-computer interaction and computer-mediated communication [11, 12, 13] indicate the relevance of two other dimensions—sociability experience and usability experience. in this study, the online offerings of an emergency preparedness program offered by a public university in the northeast was evaluated on the above four dimensions of online user experience. in addition, in this study we also examine whether online user experience had any impact on course completion. prior research in this area has shown that online distance education courses often have higher non-completion rates than traditional in-class courses [14, 15]. the reasons cited for this include student isolation and technological barriers which in turn de-motivates students and lead to course drop out [16, 17, 18]. the current study will provide insights into how the technological environments can be developed so that users (i.e. students) would not only learn but also have a positive experience that in turn enhances the probability of course completion. further, we empirically show that higher levels of student self-motivation do not translate into course completion, which in turn emphasizes the need to focus on student‘s experience during the course to enhance program success. online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 3 the remainder of this paper is organized as follows: the next section reviews the background literature and theories for this study: 1) workforce development for public health emergency preparedness, 2) online learning environment and online consumer experience, 3) cognitive affective learning, 4) social learning theory, 5) usability in distance-learning environments, and 6) motivation and course completion. following that we formally define our study research questions. this is followed by the methodology section which includes details on data collection and data analysis. next, we discuss the study results and their implications. the report ends with a brief conclusion and key recommendations for improving the users‘ online experience and thereby enhancing program effectiveness. . background workforce development for public health emergency preparedness in 1997, the u.s. department of health and human services issued a report titled ‗the public health workforce: an agenda for the 21 st century‘, which highlighted the gap in training and preparation for public health professionals for emergency preparedness [2]. it is estimated that there are around 500,000 people in the public health workforce at the federal, state and local levels. in addition, there are around 3 million people working in the healthcare system (private and non profit) who play a key role in public health emergencies [1]. in case of an emergency situation, be it an epidemic, terrorist attack or a natural disaster, these are the people who will be deployed to the front lines and the report raised concerns regarding their training and readiness. according to their assessment this ―compelling and urgent programmatic forces are making enhanced training and education opportunities for public health professionals a necessity.‖ [1]. as a result, in september 2000, the center for disease control (cdc) and the association of schools of public health together brought out a plan to develop a national network of public health preparedness centers. as part of the plan, they funded several university programs to start centers of public health preparedness (cphp) in around 10 regions across the country. cphps in all these regions have been offering relevant courses to train the public health workforce for emergency preparedness [4]. the institute of medicine later released a report in 2003 titled ―who will keep the public healthy?” that not only reiterated the need for education and training for the public health workforce, but also stated that online distance learning was the best solution to train this large number of diverse public health workers in a cost-effective manner. this has led several state universities and local governmental agencies to start their own online education programs [19, 20] for training the public health workforce in emergency preparedness. despite the growing numbers of such programs, there have been very few initiatives focused on evaluating the online learning environments of these programs, especially for the cphp offerings, other than the evaluations done by cdc itself. online (or distance) education is definitely a cost effective and efficient way of training such large numbers of public health workforce. however, in order to evaluate such programs, one needs to adopt an interdisciplinary perspective as diverse aspects (technology, social, etc.) assume importance. this study offers a theory based framework drawn from multiple disciplines to evaluate the online environments of such distance education programs. online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 4 online learning environment and online experience online classrooms and learning environments are inevitable to meet the demands of training requirements for public health emergency preparedness. it provides the economies of scale and convenience that will not be available in traditional classroom settings. there are innumerable benefits for students from online distance learning, flexibility and convenience perhaps being the most important [16]. however, this is not without many disadvantages and problems [21,22,23]. student isolation [17] and student frustrations [18] have been found to be two of the major disadvantages with online distance education. a recent study on an online medical self-paced course noted that the major challenges were technological problems and the fact that opportunities for social interaction was much lower [16]. another study found that there were eight main factors that impede online distance education: administrative issues, lack of social interaction, academic skills, technical skills, learner motivation, time and support for studies, cost and access to the internet, and technical problems [24]. sustained frustrations and isolation can impede learning, especially the cognitive and affective dimensions of the learning experience [25]. studies in this area show that these would also decrease the storage and processing capacity of working memory [26, 27]. in addition, frustration and anxiety are major factors that lead to de-motivation among students [25]. motivation is critical for this kind of online learning environments [28]. it becomes even more critical when training public health emergency preparedness workers as many students are much older, have full time jobs and other work and family commitments, as compared to young college students [20]. cognitive affective learning similar to the research in consumer psychology, where pragmatic and hedonic component of experience received much attention, in the education and learning literature, the cognitive (pragmatic) and affective (or hedonic) dimensions of learning has been the focus of many researchers. the cognitive dimension was considered most critical for learning in many of the earlier studies. while the cognitive dimension is critical, researchers also began discovering that there is an affective dimension that impacts learning, memory, retention and inference making. more recently this component received even more focus in the context of online learning which led researchers in the mit media lab to work on affective agents where a robotic computer aims to improve user‘s motivation to learn. the robotic computer is capable of expressing affect by rewarding or showing pleasure when the learner does something right, and when the learner gets distracted, it would try to entertain the learner and so on. there has also been significant work done in developing affective interface agents that are capable of working as teaching assistants in monitoring and managing online distance learning [29, 30, 31]. the objective of this line of research is to detect the affective or emotional state of the learner and provide appropriate affective or hedonic support to keep the learner engaged in the content and also motivate them to complete the tasks before them. research in consumer online behavior shows that when users are engrossed in the online activity, they do not keep track of time and get into a state of ―flow‖ [32, 33, 34]. this stream of research suggests that when people are provided with activities that they get engrossed in and start deriving fun from, they reach a state of flow [34]. in the online learning environment, if students are provided with activities that they could get immersed in and achieve a state of flow, it would not only improve learning but also online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 5 enhance the course completion rates and the student retention rate. hence, while the cognitive dimension of learning leads the student to evaluate the pragmatic value or the usefulness of the course content, it is the affective component that enables the user to have a better hedonic experience. social learning theory another relevant stream of research adopts the social learning perspective in which the conjecture is that knowledge is socially constructed and occurs when individuals engage in discourse about a subject matter [35, 36, 37]. knowledge is embedded in individuals, and by providing effective communication channels and opportunities to interact with one another—either socially or in a classroom setting—it would lead to more knowledge transfer and creation, and in turn offer a richer learning environment [36, 37]. this perspective has been widely accepted in the context of online distance education and it is often emphasized that student interactions are central and critical for a successful learning experience and consequently the success of online courses [35, 38]. these interactions could be with other students or with the instructor. in the context of online public health emergency preparedness courses, especially cphp courses, almost all the courses are ‗canned courses‘ without an instructor or fellow students. this could potentially affect the sociability experience and thereby impact learning and course completion rates. usability in distance-learning environments as mentioned previously, technological barriers and usability issues are the two most often cited reasons for student frustrations and poor completion rates. several studies have considered the usability issues of different online courses [39, 40, 41] and have broadly concluded that usability is a critical factor in determining the success of any online course. usability is the extent to which a user can successfully accomplish the tasks with effectiveness and efficiency [42]. in the distance education context, usability would be the effective and efficient accomplishment of learning related tasks or goals in the online environment (with or without using specified tools for that system). in the context of emergency preparedness training courses, it is a critical evaluation component as users‘ interaction with the system is more than users‘ interaction with the instructor. usability issues are more widely accepted by course providers as a potential problem and many understand the need to rectify them. however, usability issues are much more difficult to evaluate as users often attribute usability issues to their own lack of skills or a problem at their end (for example, their problematic home computer or internet connection). in addition, many specific usability questions such as ―is navigation through the website easy or difficult?‖ can be answered in two different ways – navigation through the website is easy or difficult for ‗everybody else who is skilled in computing technology‘; or navigation through the website is easy or difficult for ‗me‘ specifically. analysis of the results also becomes difficult as users may hold different technology standards, different levels of skills, and access to different levels of technological assistance. online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 6 to overcome these measurements issues, in the current study, we used a simple pre-validated scale to evaluate whether the overall technological environment was easy/difficult; confusing/not confusing; consistent/inconsistent; stressful/not stressful; simple/complicated and tiring/not tiring. this usability tool has been found to be effective in understanding whether the overall usability experience was satisfactory to the user [43, 44]. motivation and course completion lack of motivation has been cited as one of the major impediments to online learning [15, 24, 45, 46]. motivation to enroll for courses could come from both internal forces and external forces [47]. intrinsic (or internal) motivation has been indicated as one of the key factors that drive people to register for courses as it reflects a person‘s need to enhance their skill set, their market value, self-esteem, etc. extrinsic (or external) motivation relates to one‘s profession including mandatory job requirements, cpe credits, suggestion from one‘s boss and colleagues, etc. extrinsic motivation would also include motivation from educational institutions or the course providers (e.g. instructors, universities, and program administrators). however, the cphp is not organized to provide this kind of motivation. hence, the main sources of extrinsic motivation seemed to be from their own professional life. while both intrinsic and extrinsic motivation could certainly lead students to register for courses, there is no evidence yet that this would lead to course completion. in this study we empirically examine whether there is any significant difference in the intrinsic and extrinsic motivation levels of students who completed the courses and that of students who did not complete the courses. research questions: the above literature review suggests that poor online course experience (that in turn may arise from a lack of instructors, lack of social interactions, technological problems in the online courses, etc) could de-motivate students and lead them to drop the courses that they had registered for. the discussion also suggests that motivation to enroll for a course, while an important factor, may not be enough to ensure that the student completes the course. thus, in our empirical study, we address two research questions that reflect the above two issues. first, are there any significant differences in students‘ online course experiences (pragmatic, hedonic, sociability and usability) based on their course completion status? second, are there any significant differences in students‘ intrinsic and extrinsic motivation levels based on their course completion status? based on the theories and concepts outlined previously, we define student‘s online course experience— i.e. the overall experience a student derives from his or her interaction in the online course environment—along four dimensions: pragmatic, hedonic, sociability, and usability. pragmatic experience is the pragmatic or utilitarian value the student experiences in the online learning environment. this dimension is related to goal-oriented behavior [33] of the student and reflects whether the student found the experience in the online learning environment useful, valuable, and/or worthwhile [43, 44]. the hedonic dimension is the intrinsic value the customer derives from the interactions in the online learning environment. it reflects the enjoyment and excitement students derive during the online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 7 learning process as well as during their interactions in the online learning environment. the sociability dimension is the social experience students derive from the interactions in the online learning environment. it captures students‘ perceptions regarding the overall openness, friendliness and politeness of the community in the learning environment [11,48]. even though there weren‘t much human-human interactions in this study context, there were human-computer interactions and such interactions can also lead to sociability experience [48]. the usability dimension is defined as the students‘ experience in navigating and using the online materials. as such, this dimension captures the ease of use and clarity of the technological features of the online learning environment. higher levels of usability experience reflect the ability of the student to navigate and participate in the online learning environment smoothly and effortlessly and without any obstructions or annoyances that might distract them from their goals or interests [11]. next, we describe our empirical study.. method data collection and data analysis data was collected using a web-based questionnaire from students who had registered for the courses offered by a cphp based in a large public university in upstate ny. emails were sent to approximately 2700 students who had enrolled in one or more of the courses during the past one year. each email briefly described the study and invited the student to respond to a survey—the link to the survey was included in the email (the survey was available from the cphp‘s web site). there were 415 responses to the email invite. 38 responses had to be excluded from the analysis due to high amount of missing data. thus, there were a total of 377 usable responses. data was collected on different aspects of the online program, including, student motivations, student profile, and their overall experience with the cphp web site and with the courses (specifically, the 4 dimensions of user experience—pragmatic, hedonic, sociability and usability). the questionnaire was built using existing scales for measuring each of the variables. student‘s online course experience was measured using an existing validated scale designed to measure online experience [43, 44]. a tool to measure student motivation to enroll was developed by the cphp staff for an earlier study and was adapted and used in this survey. course completion data was collected using a simple yes/no question as to whether they completed all the courses they had registered for. a factor analysis of the data related to student motivation yielded two distinct factors— intrinsic motivation and extrinsic motivation. see table 1 for items and their factor loadings. the intrinsic motivation factor included 4 items and extrinsic motivation factor also had 4 items. online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 8 table 1: factor scores for ‘motivation’ intrinsic motivation i registered to gain more knowledge .922 i registered myself for personal development .922 i registered myself for professional development .887 i registered to do something useful/constructive .810 extrinsic motivation it was required for other educational programs .839 it was recommended by someone outside my workplace .703 it provided continuing education credit .620 it was required/highly recommended for my job .588 similarly factor analysis for each of the online experience dimensions were done separately. items and factor loadings are provided in table 2. as can be seen in table 2, pragmatic experience was measured using a 7 item scale (reliability α = 0.96), hedonic experience by using a 9 item scale (α = 0.95), sociability experience by using a 5 item scale (α = 0.87), and usability experience by using 6 item scale (α = 0.91). table 2: factor scores for online experience pragmatic scores valuable/not valuable .938 practical/impractical .918 relevant/irrelevant .915 informative/not informative .905 worthwhile/worthless .904 productive/not productive .903 useful/not useful .893 hedonic stimulating/boring .914 exciting/not exciting .892 captivating/not captivating .872 fun/not fun .856 satisfying/unsatisfying .846 enjoyable/not enjoyable .831 entertaining/not entertaining .809 deeply engrossing/not deeply engrossing .803 pleasant/unpleasant .802 online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 9 sociability inviting/uninviting .851 friendly/unfriendly .840 polite/impolite .808 personal/impersonal .799 social/unsocial .748 usability simple/complicated .866 easy/difficult .858 confusing/not confusing .827 not tiring/tiring .827 consistent/inconsistent .826 stressful/not stressful .807 an independent sample t test was used to compare the means of the four experience dimensions (pragmatic, hedonic, sociability and usability) between students who completed all the courses they registered for and students who did not complete one or more of the courses they registered for. the data was analyzed using spss, all the experience dimensions were entered as test variables and the item ‗did you complete all the courses you registered for‘ was entered as the grouping variable. similarly, an independent sample t test was used to compare the means of intrinsic and extrinsic motivation between students who completed all the courses they registered for and students who did not complete all the courses they registered for. results and discussion majority of students had registered for just one course. specifically, 157 people (41.6%) registered for 1 course; 73 people (19.4%) registered for 2 courses, and 24 people (6.4%) had enrolled for a course that was not listed in the survey. the study sample also included students from 31 countries although the large majority was from the united states. the number of female students was much higher (61%). this represents the actual student population ratio at this cphp. racial distribution was as follows: 73.7% white non hispanic, 7.6% black non-hispanic, 5.4% hispanic or latino and 5% south east asian. this distribution also mirrors the student population distribution at this cphp. the mean and standard deviation for all the 4 dimensions of online experience and the two factors of motivation are provided in table 3. table 3 –means and standard deviation of study variables variables mean s.d 1. pragmatic experience 6.1 1.12 2. hedonic experience 5.0 1.26 3. sociability experience 4.9 1.22 4. usability experience 5.6 1.15 online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 10 5. intrinsic motivation 5.4 1.96 6. extrinsic motivation 3.8 1.52 online experience & course completion analysis of the data indicates that, overall, participants had higher levels of pragmatic and usability experience compared to hedonic and sociability experience (see mean values in table 3). the results from the independent sample t-test showed that there was significant difference in the scores for all the 4 dimensions of experience between students who completed the course and students who did not. results are shown in table 4. table 4 t test results for online experience & course completion experience means n std. deviation dof t value pragmatic yes 6.2 no 5.5 275 67 .96 1.48 79.9 3.89*** hedonic yes 5.1 no 4.4 274 67 1.15 1.53 84.9 3.67*** sociability yes 5.1 no 4.3 275 67 1.07 1.57 81.6 3.68*** usability yes 5.8 no 4.9 275 67 1.04 1.32 87.3 4.92*** dof – degrees of freedom yes – completed all the courses they enrolled no – did not complete all the courses they enrolled *** p<.001; ** p<.01; *p<.05 the mean scores for pragmatic experience for students who completed the courses (m =6.2, sd =.96) was significantly higher than for those who did not complete the courses (m=5.5, sd=1.48); t(79.9)=3.89, p<.001. the mean scores for hedonic experience for students who completed the courses (m =5.1, sd =1.15) was significantly higher than for those who did not complete the courses (m=4.4, sd=1.53); t(84.9)=3.67, p<.001. similarly, the mean scores for sociability experience for students who completed the courses (m =5.1, sd = 1.07) was significantly higher than for those who did not complete the courses (m=4.3, sd=1.57); t(81.6)=3.68, p<.001. finally, the mean scores for usability experience for students who completed the courses (m =5.8, sd =1.04) was significantly higher than for those who did not complete the courses (m=4.9, sd=1.32); t(87.3)=4.92, p<.001. overall, the results support the broader study thesis that students who experience higher levels of pragmatic, hedonic, sociability and usability experiences are more likely to complete the course(s) they registered for compared to those who report lower levels. in other words, these results indicate that people who dropped out had less positive online experience on all the four dimensions—pragmatic, hedonic, sociability and usability. the four-dimensional online experience questionnaire is useful in such situations where one can capture the underlying experience and derive insights on what aspect of the user experience really leads to non completion. online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 11 our analysis also shows that students rated ‗hedonic‘ experience and ‗sociability‘ experience lower than ‗pragmatic‘ and usability experience. for sociability experience, a sizeable number of the students gave a rating of 4 (neutral) on a scale of 1 to 7, which indicates that they did not perceive sociability to be either negative or positive. it could also indicate the lack of sociability experience in this cphp online program. motivation and course completion there was no statistically significant difference in students‘ extrinsic motivation levels between those who completed all the courses they registered for and those who didn‘t (see table 5). there was mild statistically significant difference in students‘ intrinsic levels between those who completed all the courses they registered for and those who did not (m=5.2, sd =2.01); t(106.7) = -3.2, p<.05. however, the results from the independent sample t test indicate a negative effect. in other words, students who completed all the courses they registered for had lower intrinsic motivation levels compared to those who did not complete all the courses they registered for. this indicates that lower levels of intrinsic motivation do not imply that they would drop out from the course. on the same lines, higher levels of intrinsic motivation do not imply that they would complete the course. in short, the results from this study indicate that student motivation (both intrinsic and extrinsic) is not a good predictor of course completion. table 5 t test results for motivation and course completion motivation means n std. deviation dof t value intrinsic yes 5.2 no 6.0 238 59 2.01 1.62 106.7 -3.2* extrinsic yes 3.8 no 3.9 213 51 1.45 1.78 66.7 -.259 dof – degrees of freedom yes – completed all the courses they enrolled no – did not complete all the courses they enrolled *** p<.001; ** p<.01; *p<.05 this finding combined with the earlier finding further indicates the importance of students‘ online experience (all the four dimensions) for maintaining student interest and ensuring that they complete the courses. in other words, while motivation may play a key role in bringing the student to the program (i.e. enrolling for the course), it is their perceived experience during the online course that critically determines whether or not they would complete the course. study implications the results from this study have several implications for cphps, and more generally, for similar online training programs. first, this study indicates the need to focus on the four key dimensions of user‘s online experience (i.e. their underlying feelings and perceptions) rather than on ad-hoc issues. prior studies and evaluations have mainly considered specific problems perceived by the course provider rather than the actual user experience. the evaluation tool described here brings out users‘ sentiments online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 12 about different aspects of the program and gives a much more fundamental and holistic understanding of the program‘s potential weaknesses and areas for improvement. the study also highlights the importance of hedonic and sociability experience for students in such online training environments. many online courses focus mainly on the pragmatic value of a particular course for the students and neglect the potential hedonic experience. while pragmatic experience is important and should be the primary focus, boredom and lack of fun can make students weary and demotivated. including elements that enhance fun and entertainment as part of the learning experience would be invaluable. even in face-to-face classroom situations, instructors constantly try to include fun activities such as field trips, role-playing, including videos and movie clips etc that are relevant for the content of the course. the type of fun activities would be different in an online course (a few suggestions are provided in table 6), but necessary especially for training programs that use ‗canned courses‘. as discussed previously, social learning theory suggests the importance of, sociability experience in learning; the current study findings indicate that sociability experience is equally important to ensure higher course completion rates. good sociability experience prevents students from ―feeling lonely‖, and more importantly, enables them to engage in ―active learning‖. indeed, student interactions have been found to be critical for the success of many online distance education courses [49, 50, 51]. such interactions allow students to feel that they are part of a community of learners and share experiential knowledge that enhance the overall quality of learning. finally, this study found that majority of the students who enrolled in these programs were self-driven or self-motivated. intrinsic factors such as professional and personal development seem to drive these public health professionals to enroll in such training courses. at the same time, such motivation did not translate into ensuring course completion. this implies that rather than depend on student motivation, course providers would need to provide such self-motivated individuals with a positive and engaging online learning experience to ensure high levels of course completion. conclusions and key recommendations key recommendations that follow from the study findings are given below (also summarized in table 6). 1) improving pragmatic experience: in this study, the majority of the students found the courses to be useful and valuable (the mean score for pragmatic experience was higher than those for the other three experience dimensions). however, this is still relative to the very low hedonic and sociability experiences and indicates the potential for improvement. an important means to enhance pragmatic experience is effective student expectations management. students should be able understand upfront what they will be getting out of each course. this can be done by bringing more clarity to course descriptions and also detailing as to what specific goals students will be able to accomplish by taking each course. it will also help to indicate who would benefit by taking a particular course. 2) improving hedonic experience: hedonic or fun and entertainment from these courses were rated quite low. it is true that fun and entertainment is not one of the primary objectives of these courses. however, as mentioned previously, when people get engrossed in the learning material, their learning online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 13 and retention of the material are typically much higher [52]. in addition, they would try to finish the courses, instead of procrastinating and/or getting distracted with other things. an effective way to improve hedonic experience is to create more interactive and fun user interface. for example, one could incorporate video clips made in ‗second life‘ that will give the user a personal view of a disaster and how things could be as he/she approaches a disaster area in addition to being a fun experience. play2train http://play2train.us/wordpress/ developed by idaho bioterrorism awareness and preparedness program using ‗second life‘ is a good example of this. 3) improving sociability experience: sociability experience was another weak factor in cphp courses... as noted previously, positive sociability experience would enable students to feel that they are part of the overall community of students who are enrolled in the program. one solution would be to provide students with access to an online community/forum within the cphp that will enable interactions with fellow students as well as with the cphp staff. this would not only improve students‘ sociability experience, but also enhance their learning and networking potential, and in turn, improve student retention. developing such forums is a very cost-effective solution with proven benefits given the low cost of associated information technologies. 4) improving usability experience: it is important to ensure that the design of the online environment provides seamless and enjoyable navigation experience for the user. best practices in usability include offering simple and clutter less user interface, intuitive navigational features, and avoiding technological jargons in user guidance. . in addition, usability can be significantly improved by offering online programs on mobile platforms and thereby catering to today‘s public health worker who is likely to be very mobile. if courses can be accessed through smart phones (this would require redesigning the interface to fit the mobile device) it would improve the convenience factor significantly. in conclusion, there are ample opportunities to improve the pragmatic, hedonic, sociability and usability experiences of the target audience. this is critical to improve the participants‘ learning and retention as well as the completion rates for the courses offered. online emergency preparedness programs are likely to play a crucial role in preparing emergency responders at all levels in the future and their success has critical implications for public health informatics. however, we need more studies in the future to understand the factors that affect students‘ overall experience in the online learning environment of cphp courses. future research could focus on understanding how the experience (pragmatic, hedonic, sociability and usability) would impact student performance in the courses, student learning and retention of the subject matter, and more importantly, their real life job performance. in addition, conducting qualitative studies with a cohort group of students could help us better understand the factors that shape the overall experience specific to this set of population as well as whether such online training is an effective long term solution for training our public health workers. http://play2train.us/wordpress/ online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 14 table 6 key strategies for improving course completion rates and overall program success key strategies how to benefits for students benefits for cphp 1) improving pragmatic experience expectations management: make clear what the content of the course is make it clear upfront who would benefit from the course and who should be taking it. collect feedback from students at the end of each course on how useful and valuable the course was. will not unnecessarily register for a course that they do not need. will be able to target courses better at the right individuals will be able to improve the content of the course 2) improving hedonic experience improve fun and entertainment: add more interactive elements in the courses include video clips made with ‗second life‘. e.g. play2train http://play2train.us/wordpress/ include pictures and graphics (pictures speak a thousand words) will capture the attention of students will improve learning and retention of the material. will see courses as more fun than as a chore. will keep student engrossed (time flies when you are deeply engrossed). will keep them from getting distracted. will improve the success of the overall program. will improve student ratings will be able to attract more students (such online programs don‘t have any boundaries, so the potential is immense). will be able to retain students and get them to come back for more courses. 3) improving sociability experience improve possibilities for social interaction. provide an online community/forum for students to interact allow students as well as cphp staff to interact in the community will improve networking potential will improve their social experience will improve learning and retention (collective learning seems to improve information processing) will improve cphp‘s relationship with students (strong ties). will be able to attract more students through ‗word-of-mouth‘ marketing (which is a potential outcome http://play2train.us/wordpress/ online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 15 offer some courses in ‗blended format‘ – i.e. part online and part in-class. will feel part of the cphp community will not feel that they are on their own blended format offers the convenience of online courses but will provide some f2f time that will enhance sociability experience. however, this will be limited to local students. of such online communities). will be able to understand student needs by keeping abreast of the ongoing discussions in the community (instant feedback loop). -online communities have been found to improve motivation as well (huett et al, 2007) blended format will allow cphps to improve the variety of courses offered. it will allow cphps to get to know their students better. will improve student retention in the local region. 4) improving usability experience 1) improve usability experience by using some of the standard usability practices (nielson, 2000). update the websites regularly (at least every 2 years or so if not more frequently) using the latest technologies use simple designs (nielson, 2000) -remove unnecessary content and avoid clutter. 3) make cphp courses accessible through mobile phones improved usability would make it easier for students to access the course materials and reduce the learning curve related to the course technologies -convenience would be the biggest benefit for students. beneficial for public health improved usability can improve student retention and continued enrollment. benefits for cphp include improving versatility of online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 16 mobile phones are now very well equipped with fast connections and readable interfaces. workers who are always travelling. very beneficial for people who use public transportation and have lot of time while travelling as well as during wait times. courses. offering courses using more than one platform will improve the reach and enrollment levels will improve completion rates and continued enrollment. references [1] centers for disease control and prevention (us). bioterrorism and public health emergency preparedness and response: a national collaborative training plan: strengthening preparedness at the frontlines. executive summary. 2002 feb. [2] department of health and human services, public health service (us). the public health workforce: an agenda for the 21st century, a report of the public health functions project, 1997. available from: url: http://www.health.gov/phfunctions/pubhlth.pdf. [3] institute of medicine of the national academies. who will keep the public healthy: educating public health professionals for the 21st century. (accessed on may1, 2010). november 4, 2002. available from: url: http://www.iom.edu/report.asp?id=4307. [4] office for domestic preparedness, department of health and human services (us). odp approach for blended learning key program information. february 10, 2003 version 1. (accessed on may 1, 2010) available from: url: http://www.ojp.usdoj.gov/odp/training_bl.htm. [5] office of public health preparedness and response (ophpr).centers for public health preparedness (cphp) program. (accessed on may 1, 2010) available from: url: http://emergency.cdc.gov/cdcpreparedness/cphp/background.asp [6] forgas jp. (ed.). feeling and thinking: affective influences on social cognition. new york: cambridge university press. 2000. [7] isen am, labroo aa. some ways in which positive affect facilitates decision making and judgment, in s. schneider & j. shanteau (eds.) emerging perspectives on judgment and decision research. 2003. ny, cambridge: 365-393. [8] overby jw, lee ej. the effects of utilitarian and hedonic online shopping value on consumer preference and intentions, j bus res, 2006, 59, pp. 1160-1166. [9] voss ke, spangenberg er and grohmann b. measuring the hedonic and utilitarian dimensions of consumer attitude. j mktg res, 2003, xi, pp. 310-320. [10] dhar r, and wertenbroch k. consumer choice between hedonic and utilitarian goods. j mktg res, 2000, xxxvii, pp.60–71. [11] nambisan p, watt jh. managing customer experience in online communities. journal of business research, in press. http://www.health.gov/phfunctions/pubhlth.pdf http://www.iom.edu/report.asp?id=4307 http://www.ojp.usdoj.gov/odp/training_bl.htm http://emergency.cdc.gov/cdcpreparedness/cphp/background.asp online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 17 [12] nielsen j. designing web usability: the practice of simplicity. indianapolis: new riders, 2000. [13] shneiderman b, catherine p. designing the user interface: strategies for effective human-computer interaction, 4th ed. boston: addison wesley professional, 2004. [14] dupin-bryant pa. (2004). pre-entry variables related to retention in online distance education [electronic version]. the american journal of distance education, 18(4), 199-206. [15] huett jb, kalinowski ke, moller l, huett kc. (2008). improving the motivation and retention of online students through the use of arcs-based e-mails. american journal of distance education, 2008; 22(3):159-176. [16] may l, acquaviva kd, dorfman a, laurie posey l. medical student perceptions of self-paced, web-based electives: a descriptive study, american journal of distance education, 2009; 23 (4): 212 223. [17] twigg ca. is technology a silver bullet? educom review, 1997; 28-29. [18] hara n, kling r. students' frustrations with a web-based distance education course. first monday.1999; 4(12) (december) at http://www.firstmonday.dk/issues/issue4_12/index.html [19] harrison lm, davis mv, macdonald pdm, alexander lk, cline js, alexander jg, rothney ee., rybka tp. & stevens rh. development and implementation of a public health workforce training needs assessment survey in north carolina public health rep. 2005; 120(suppl 1): 28–34. [20] nysdoh. roadmap: strengthening the public health workforce in new york state 2006. [accessed on may 1, 2010. available from url: http://www.health.state.ny.us/press/reports/docs/strengthening_the_public_health_workforce.pdf [21] bromley h, apple mw. education/technology/power: educational computing as a social practice. albany, n.y.: suny press; 1998. [22] jaffee d. institutionalized resistance to asynchronous learning networks. journal of asynchronous learning networks. 1998; 2 (2). http://www.aln.org/alnweb/journal/vol2_issue2/jaffee.htm [23] wegerif r. the social dimension of asynchronous learning networks. journal of asynchronous learning networks, 1998; 2 (1) http://www.aln.org/alnweb/journal/vol2_issue1/wegerif.htm [24] muilenburg ly, berge zl. student barriers to online learning: a factor analytic study, distance education, 2005; 26 (1), pp: 29 – 48. [25] jonassen dh, grabowski bl. handbook of individual differences, learning, and instruction. hillsdale, n.j.: erlbaum; 1993. [26] darke s. anxiety and working memory capacity, cognition and emotion, 1998; 2 (2): 145 154. [27] darke s. effects of anxiety on inferential reasoning task performance, journal of personality and social psychology, 1988; 55 (3): 499-505. [28] abrahamson ce. issues in interactive communication in distance education, college student journal, 1998; 32 (1): 33 43. [29] choy so, ng sc, tsang, yc. software agents to assist in distance learning environments. educause quarterly, 2005; 28 (2): 34-40. [30] jafari a. conceptualizing intelligent agents for teaching and learning, educause quarterly, 2002; 25 (3): 28-34. [31] neji m and ben ammar m. agent-based collaborative affective e-learning framework, the electronic journal of e-learning, 2007; 5(2): 123 134, available online at www.ejel.org [32] csikszentmihalyi m. flow: the psychology of optimal experience, harper & row, new york, ny; 1990. [33] hoffman dl, novak tp. flow online: lessons learned and future prospects, journal of interactive marketing, 2009; 23(1), 23-34. (pdf) http://www.firstmonday.dk/issues/issue4_12/index.html http://www.health.state.ny.us/press/reports/docs/strengthening_the_public_health_workforce.pdf http://www.aln.org/alnweb/journal/vol2_issue2/jaffee.htm http://www.aln.org/alnweb/journal/vol2_issue1/wegerif.htm http://www.ejel.org/ http://elabresearch.ucr.edu/blog/uploads/publications/hoffman_novak_2009_jim.pdf online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 18 [34] ghani ja, deshpande sp. task characteristics and the experience of optimal flow in humancomputer interaction, the journal of psychology, 1994, 128 (4):381-391. [35] hill, jr, song, l, west re. social learning theory and web-based learning environments: a review of research and discussion of implications, american journal of distance education, 2009; 23 (2):88-103. [36] henning w. everyday cognition and situated learning. in handbook of research on educational communications and technology, 2004; 2 nd ed., ed. d. jonassen, 143-168. mahwah, ny: erlbaum. [37] schmitt ff. the justification of group beliefs. in ed. schmitt ff, socializing epistemology: the social dimensions of knowledge, 1994; maryland: rowman and littlefield. pp. 257-88. [38] garrison dr, cleveland-innes m. facilitating cognitive presence in online learning: interaction is not enough. the american journal of distance education, 2005; 19 (3): 133–148. [39] tselios n., avouris n., dimitracopoulou a., daskalaki s. evaluation of distance-learning environments: impact of usability on student performance, international journal of educational telecommunications, 2001; 7(4): 355-378. [40] duggan, mh, adcock ab. animated agents teaching helping skills in an online environment: a pilot study. journal of interactive online learning, 2007; 6(1): 56-71. [41] volery t, lord d. critical success factors in online education. international journal of educational management, 2000; 14 (5): 216 – 223. [42] karat j. evolving the scope of user-centered design. communications of the acm, 1997; 40 (7): 33 – 38. [43] nambisan p, gustafson d, pingree s, hawkins r. patients‘ sociability and usability experience in online health communities: impact on attitudes towards the healthcare organization and its services. international journal of web-based communities (special issue on web-based communities and healthcare), 2010, 6 (4): 395-409. [44] nambisan p. evaluating patient experience in online health communities: implications for healthcare organizations. health care management review, in press. [45] astleitner h, keller j. a model for motivationally adaptive computer-assisted instruction. journal of research on computing in education, 1995; 27 (3): 270–280. [46] gabrielle d. the effects of technology-mediated instructional strategies on motivation, performance, and self-directed learning. ph.d. diss., florida state university, tallahassee. 2003; (accessed on may10, 2010)available at http://gabrielleconsulting.com/docs/gabrielleaect.pdf [47] driscoll mp. psychology of learning for instruction. boston: allyn and bacon, 1994. [48] kreijns k, kirschner pa, jochems w. the sociability of computer-supported collaborative learning environments, educational technology & society, 2002; 5 (1): 8-22 [49] brown re. the process of community-building in distance learning classes. journal of asynchronous learning networks, 2001; 5(2): 18-35. [50] swan k. (2002). building learning communities in online courses: the importance of interaction. education, communication & information, 2002; 2(1): 23 – 49. [51] richardson jc, swan k. (2003). examining social presence in online courses in relation to students‘ perceived learning and satisfaction. journal of asynchronous learning networks, 2003; 7 (1): 68-88. [52] malone tw, lepper mr. making learning fun: a taxonomy of intrinsic motivations for learning in r.e. snow and m.j. farr (eds.), aptitude, learning and instruction, hillsdale, nj: ebraum, 1987, 223-253. http://gabrielleconsulting.com/docs/gabrielleaect.pdf online public health preparedness training programs: an evaluation of user experience with the technological environment online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 19 correspondence: priya nambisan, phd assistant professor dept. of health policy, management, & behavior school of public health, rm. 185 affiliated faculty: dept. of informatics college of computing and information university at albany, suny 1 university place, rensselaer, ny 12144 ph: (518) 402-0332; fax: (518) 402-0414 email: pnambisan@albany.edu mailto:pnambisan@albany.edu crappdf.pdf isds annual conference proceedings 2013. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 167 (page number not for citation purposes) isds 2013 conference abstracts antibiotic susceptibility of salmonellosis pathogens laziz tuychiev*, amir m. bektemirov and gulnara abdukhalilova research institute of epidemiology, microbiology and infectious diseases, tashkent, uzbekistan � �� �� �� � � �� �� �� � objective ����������� ����� �� ������ ������ ������� ��� ������� �� ������ ����� � ������� �� ������ ����� �� ��� ����� ��� ��� ��� introduction �������� ��������� ��� ���� ������������ �� �� ��� ����� �� ������ ������ ����� ����� ����� ������ ����� ������� �� ���� �� ��� ������� ���������������� ��������� �� �������� ��� ����� ������������������� ���������������� ������ �������� ����� ������� �� �� ��� ������� ��� �������!"��#�������� ����$%%&��� ������ ��� ��� �������'((&� methods ) ��� ��������� ������������ ������� �� ��������� �������� �� ���� ������� ��� �������� ����������� �� �� ������)����� �� �������� *)���" �����)�� ��������)����"����������)��� ��� ��+�����)�� �� �� � ������� � ���� ����������,������ � ��!"��#������ ���� ����� ��� ���� �� ����$%%&�*-.��� ����+���������� �'((&�*'.��� ����+��/����� �� ����� ����������� ������������������������������������ �� ���� ���� ������� �� ���� �� ��������� � �������� ��� ������)���� �������0�� �� �� ����� �������������*)0 ���'($'+�� ����� ���������������������� �� � ��� ��� ��*1�)+����� �� ������1�)%(��2��� � ��� ��� �� ����� ������������ �� �������������3$'�4�(�(5�� �6��� results 2���1�)��������� �-.��� ����� �� ��������� �������$%%&��� ����� � �� ��7�)���" ������.�(�4�$5�(�� �6���*1�)%(�&�(�� �6��+��)�� � ���������(�3�� �6����)����"��������(�'3�� �6����)��� ��� �����(�(5� '�(�� �6���*1�)%(�$�(�� �6��+������)�� �� �� ��8�(�(5�� �6���� 2���1�)��������� �-.��� ����� �� ��������� �������'((&�� �������� ������� ���)����� �� ������������������� ����� ��(�'3���93$'�� �6 ���*1�)%(�-'�(�� �6��+������� �)�� �� �� �������4�(�3�4�$�(�� �6 ���*1�)%(�$�(�� �6��+� 2���1�)��������� �'&��� ����� �� ������ ����������$%%&��� ����� � �� ��7�)���" ������$�(�4�'�(�� �6���*1�)%(�'�(�� �6��+��)�� � �������4�(�(5�(�'3�� �6���*1�)%(�(�('3�� �6��+��)����"������ 4�(�$'3�� �6����)��� ��� ���4�(�(5�'�(�� �6���*1�)%(�$�(�� �6 ��+��)�� �� �� �����8�(�(5� �6����2���1�)��������� �'.��� ����� �� ������ ����������'((&��� ������ �� ��7�)���" ������'�(�4�&�(�� �6 ���*1�)%(�.�(�� �6��+��)�� �������4�$�(�4�'�(�� �6���*1�)%(� '�(�� �6��+��)����"������4�(�'3�$'&�� �6���*1�)%(�-'�(�� �6��+�� )��� ��� ���4�(�(5�'�(�� �6���*1�)%(�'�(�� �6��+��)�� �� �� ��� ��8�(�(5�� �6��� conclusions 2����� ��� ��� ��� �� ���*�� ����$%%&+����������� ���������� *���� �'((&+��� ����� ���������� ����� � ���������������,������ � �� !"��#��������� ��� ���������������� ������ ������ �� �� ��� ���� �������� ����� ������� ���������������� � �� �� �� ����������� ������ 2�� ��� ��� ��� �� ������ ������������� ����������� ������� ������� ������ ������������ �������� ��� ���� ����� ������ �������� ���� $%%&� keywords /����� ����� ������� �:� �� ������:�!"��#����� references $�� ,�������)���� ������;�����;������ ���/����� �����,������� �� <�������� ��� ���������� � ���� ������� ��; ��� ������ ��������2���� ������=� �� � � ����>��?����1���� ���@$*$(+7�$-.%�$-33��'((%� '�� 1� ��<��a ��������>�������1� ����������������� �����������1����� � ���,������� �������<� ����) ��� �� �� ��b ����� ����� ��� ������ ���� � ���� �������c�� ��������� �� ���d������������� � �� �6����� ? ��$3��b ��-�1� ��'((%� -�� a;�; �#�����c������ � �������/����� �����,������� �� ��c��� � � ;��� ��������d���� ��,��� ���e������ ������>�;����f�������? ���-@�� b �-��'((&�����5(�5% *laziz tuychiev e-mail: l_tuychiev@mail.ru� � � � online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 6(1):e12, 2014 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts detecting changes in chief complaint word count: effects on syndromic surveillance jessica sell*, robert mathes and marc paladini nyc department of health and mental hygiene, long island city, ny, usa objective to identify changes in emergency department (ed) syndromic surveillance data by analyzing trends in chief complaint (cc) word count; to compare these changes to coding changes reported by eds; and to examine how these changes might affect the ability of syndromic surveillance systems to identify syndromes in a consistent manner. introduction the new york city (nyc) department of health and mental hygiene (dohmh) receives daily ed data from 49 of nyc’s 52 hospitals, representing approximately 95% of ed visits citywide. chief complaint (cc) is categorized into syndrome groupings using text recognition of symptom key-words and phrases. hospitals are not required to notify the dohmh of any changes to procedures or health information systems (his). previous work noticed that cc word count varied over time within and among eds. the variations seen in cc word count may affect the quality and type of data received by the dohmh, thereby affecting the ability to detect syndrome visits consistently. methods the daily mean number of words in the chief complaint field were examined by hospital from 2008-2011. spectral analyses were performed on daily cc word count by hospital to explore temporal trends. change point analysis (cpa) using taylor’s method with a maximum change level of four was conducted on the cc field by hospital using 1,000 bootstrap samples. according to taylor, a level one change is the most important change detected on the program’s first pass through the data. for this analysis, a change point was considered significant if it was level 1, detected an average change of more than 0.50 words per day, and was sustained for at least 6 months before a level 2 change of at least 0.50 words occurred. results of the cpa were compared to reported changes identified by a survey conducted by dohmh staff of 49 hospitals that collected information about their his and coding practices, including any recent system changes. when a significant level one change was identified, time series graphs for six months before and after the change were created for five syndromes (cold, diarrhea, fever-flu, influenza-like-illness, and respiratory) and the syndrome’s constituent symptom categories (e.g. cough fever, etc.). changes in syndrome count and composition at the level one change in word count were noted. results the mean chief complaint word count across all hospitals from 2008 – 2011 in nyc was 3.14, with a range of 0 to 18 words. cpa detected a significant level 1 change in 21 hospitals, with a mean change of 0.60 words, with 9 increases (mean= 0.71 words) and 12 decreases (mean= 0.53 words). according to the results of a survey of 49 nyc eds, 19 have changed coding practices or health information systems since 2008. cpa identified a coincident and significant shift in word count for 8 of these hospitals. cpa also detected significant shifts in word count for 13 hospitals that did not report any changes. figure 1 shows the results of cpa from one ed in nyc we observed immediate changes in daily syndrome count after the detected change in cc word count. for example, respiratory syndrome count increased with increased word count and decreased with decreased word count for 10 of the 21 eds with a significant change in word count. only 2 eds saw an opposite effect on respiratory syndrome count. meanwhile, 9 eds saw no obvious change in respiratory syndrome count. furthermore, these changes in daily cc word count coincided with subsequent changes in syndrome composition, the breakdown of syndromes into constituent symptoms. conclusions change point analysis may be a useful method for prospectively detecting shifts in cc word count, which might represent a change in ed practices. in some instances changes to cc word count had an apparent effect on both syndrome capture and syndrome composition. further studies are required to determine how often these changes happen and how they may affect the quality of syndromic surveillance. figure 1: mean daily cc word count with cpa results marked. keywords chief complaint; word count; change point analysis references taylor, w. a. (2000).”change-point analysis: a powerful tool for detecting changes”. retrieved july 5, 2012, from http://www.variation.com/cpa/tech/changepoint.html *jessica sell e-mail: jsell@health.nyc.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e21, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts spatial scan statistics for models with excess zeros and overdispersion max sousa de lima2, luiz h. duczmal*1 and letícia p. pinto1 1universidade federal de minas gerais, belo horizonte, brazil; 2universidade federal do amazonas, manaus, brazil objective to propose a more realistic model for disease cluster detection, through a modification of the spatial scan statistic to account simultaneously for inflated zeros and overdispersion. introduction spatial scan statistics [1] usually assume poisson or binomial distributed data, which is not adequate in many disease surveillance scenarios. for example, small areas distant from hospitals may exhibit a smaller number of cases than expected in those simple models. also, underreporting may occur in underdeveloped regions, due to inefficient data collection or the difficulty to access remote sites. those factors generate excess zero case counts or overdispersion, inducing a violation of the statistical model and also increasing the type i error (false alarms). overdispersion occurs when data variance is greater than the predicted by the used model. to accommodate it, an extra parameter must be included; in the poisson model, one makes the variance equal to the mean. methods tools like the generalized poisson (gp) and the double poisson [2] may be a better option for this kind of problem, modeling separately the mean and variance, which could be easily adjusted by covariates. when excess zeros occur, the zero inflated poisson (zip) model is used, although zip’s estimated parameters may be severely biased if nonzero counts are too dispersed, compared to the poisson distribution. in this case the inflated zero models for the generalized poisson (zigp), double poisson (zidp) and negative binomial (zinb) could be good alternatives to the joint modeling of excess zeros and overdispersion. by one hand, zero inflated poisson (zip) models were proposed using the spatial scan statistic to deal with the excess zeros [3]. by the other hand, another spatial scan statistic was based on a poisson-gamma mixture model for overdispersion [4]. in this work we present a model which includes inflated zeros and overdispersion simultaneously, based on the zidp model. let the parameter p indicate the zero inflation. as the the remaining parameters of the observed cases map and the parameter p are not independent, the likelihood maximization process is not straightforward; it becomes even more complicated when we include covariates in the analysis. to solve this problem we introduce a vector of latent variables in order to factorize the likelihood, and obtain a facilitator for the maximization process using the e-m (expectation-maximization) algorithm. we derive the formulas to maximize iteratively the likelihood, and implement a computer program using the e-m algorithm to estimate the parameters under null and alternative hypothesis. the p-value is obtained via the fast double bootstrap test [5]. results numerical simulations are conducted to assess the effectiveness of the method. we present results for hanseniasis surveillance in the brazilian amazon in 2010 using this technique. we obtain the most likely spatial clusters for the poisson, zip, poisson-gamma mixture and zidp models and compare the results. conclusions the zero inflated double poisson spatial scan statistic for disease cluster detection incorporates the flexibility of previous models, accounting for inflated zeros and overdispersion simultaneously. the hanseniasis study case map, due to excess of zero cases counts in many municipalities of the brazilian amazon and the presence of overdispersion, was a good benchmark to test the zidp model. the results obtained are easier to understand compared to each of the previous spatial scan statistic models, the zero inflated poisson (zip) model and the poisson-gamma mixture model for overdispersion, taken separetely. the e-m algorithm and the fast double bootstrap test are computationally efficient for this type of problem. keywords scan statistics; zero inflated; overdispersion; expectation-maximization algorithm acknowledgments the authors acknowledge the grants provided by fapeam and cnpq. references [1] kulldorff, m. (1999). spatial scan statistics: models, calculations and applications, in j. glaz & n. balakrishnan (eds), scan statistics and applications, springer netherlands, pp. 303–322. [2] efron, b. (1986) double exponential families and their use in generalized linear regression, journal of the american statistical association, 81, pp. 709-721. [3] cançado a., da silva c. and da silva m.(2011) a zero-inflated poisson-based spatial scan statistic. emerging health threats journal, 2011;4: [4] zhang t., zhang z.; lin g.(2012) spatial scan statistics with overdispersion. statistics in medicine,31(8):762-774. [5] davidson, r. and j. g. mackinnon (2001). “improving the reliability of bootstrap tests”, queen’s university institute for economic research discussion paper no. 995, revised. *luiz h. duczmal e-mail: duczmal@ufmg.br online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e88, 2013 nc catch: advancing public health analytics 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 nc catch: advancing public health analytics james studnicki 1 , john w. fisher 1 , christopher eichelberger 2 , colleen bridger 3 , kim angelon-gaetz 4 , debi nelson 4 1 university of north carolina, charlotte college of health and human services department of public health sciences 2 college of computing and informatics software solutions laboratory, charlotte, north carolina 3 gaston county health department 3 gastonia, north carolina 4 north carolina office of healthy carolinians/health education 4 raleigh, north carolina abstract the north carolina comprehensive assessment for tracking community health (nc catch) is a web-based analytical system deployed to local public health units and their community partners. the system has the following characteristics: flexible, powerful online analytic processing (olap) interface; multiple sources of multidimensional, event-level data fully conformed to common definitions in a data warehouse structure; enabled utilization of available decision support software tools; analytic capabilities distributed and optimized locally with centralized technical infrastructure; two levels of access differentiated by the user (anonymous versus registered) and by the analytical flexibility (community profile versus design phase); and, an emphasis on user training and feedback. the ability of local public health units to engage in outcomes-based performance measurement will be influenced by continuing access to event-level data, developments in evidence-based practice for improving population health, and the application of information technology-based analytic tools and methods. nc catch: advancing public health analytics 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 introduction the 1988 institute of medicine (iom) report titled “the future of public health”, and other iom reports since then, have advanced the idea that community health status could be improved by a data-driven continuous iterative cycle of assessment, program implementation, reassessment of results, and further implementation of newly focused programs. 1 these reports emphasized the need for a regular and systematic collection, assemblage, and analysis of information on the health status of communities which would support priority setting and evaluation of the impacts of programs and policies, and stimulate the collaboration and actions necessary to improve community health outcomes. 2,3 in response to this measurement mandate, there has been a continuing production of frameworks, models, and community health status report cards. 4,5,6,7 each of these efforts presents a rendition of community health status accompanied by a set of indicators or measures linked to determinants of health (e.g. poverty, race), root causes of adverse variations on health (e.g. smoking, obesity), or key intervention points related to selected health issues (e.g. immunizations, screening). in some cases, these community measures are weighted and mathematically manipulated in order to derive a community score or ranking. 8,9 static models using a fixed selection of indicators and a similarly static scoring algorithm provide the basis for coarse comparisons, but are not alone sufficient to enable communities to discover their own unique determinant-outcome relationships and practice priorities for subpopulations defined by race, ethnicity, age, poverty, geography, outcomes and other factors. 10 brief catch history the catch methodology evolved from a series of comprehensive community health status assessments conducted in florida in the 1990s. these extensive hardcopy reports were manually cobbled together from multiple data sources using a comparative framework which enabled each community (usually a county or group of counties) to compare itself against sociodemographically similar peer communities. 11 funding from the u.s. department of commerce, telecommunications and information infrastructure assistance program (tiiap) in 1998 enabled the automation of many of the analytic steps and resulted in larger and more complex reports, as well as a vibrant research agenda with studies in racial and ethnic disparities, the impact of special taxing districts on health outcomes, warehouse applications to bioterrorism alert algorithms, and improved methods for community health status assessment. 12,13,14,15 with the realization that the same data and analytical capability required to support these research endeavors was necessary to understanding variations in the health status of defined populations, the catch effort in north carolina evolved away from simply providing data and reports to deploying an operating analytical environment composed of a rich repository of data harnessed to a powerful analytic capability. nc catch: advancing public health analytics 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 nc catch: system elements in north carolina, the state center for health statistics (schs) maintains an inventory of databases to support the mandated community health status assessment process and works closely with the office of healthy carolinians and health education (ohc) and local community partnerships in performing assessments and mobilizing community action. with assistance from a health services research and technical development team from the university of north carolina at charlotte (uncc), the nc division of public health initiated the development and deployment of a system that would address many of the weaknesses of current systems, thus bringing the benefits of modern web-enabled software technology to public health. key components of the system include: data from multiple sources. extant data from multiple sources with conformed definitions are organized into the warehouse: demographic/population data at the census tract level; mortality; pregnancies; births; hospital discharges; emergency room visits; behavioral risk factor survey data (regional and county level only); cancer incidence and treatment data; and other miscellaneous social, economic, and health related data available at various levels of granularity. data are geocoded to the census tract where possible. an important future source of data is the electronic health record (ehr), since the analytical capabilities of the system are congruent with the goal of at least one category of “meaningful use” of ehrs as specified by the office of the national coordinator (onc) for information technology 16,17 ; i.e. to improve population and public health. the ability to move clinical practice data from health information exchanges (hies) into a catch data warehouse in a timely manner will enable broader use of that data for management, evaluation and policy purposes. on-line analytical processing (olap). the most prevalent electronic storage system is the relational database, in which data elements are organized into two-dimensional tables of columns (that remain fixed) and rows (that can be added to, deleted from, and modified in place). the following (table 1) illustrates one such simplified data table. table 1. simplified death record death record i.d. age race cause of death 2185 65 01 icd-10-cm codes 7364 85 01 icd-10-cm codes 1122 21 02 icd-10-cm codes 7419 53 03 icd-10-cm codes this structure facilitates storing transactions which are single (row-based) assertions about each death: patient identity, cause of death, age and race of the deceased, etc. each different type of data, however, requires a separate data table. these individual tables can be logically joined through common data elements such as the death record id or cause of death. though efficient for storing individual facts, this structure is not particularly conducive to open-ended data exploration tasks because the user has to traverse all of the tables to assemble a coherent view of nc catch: advancing public health analytics 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 the data that are spread across the entire transactional database. olap-based data warehouses address this shortcoming by providing pre-assembled collections of system-wide data into hypercubes (or just "cubes" for brevity). the following (figure 1) illustrates one such simplified cube: figure 1. multidimensional “hypercube” even though this example cube contains only some of the columns from the preceding data table, it can contain an arbitrary number of dimensions, typically including geography as well as time. every intersection of these dimensions represents a cell that can contain one or more precomputed, aggregate measures such as the total number of deaths, mean mortality rates, total cost of services, etc. the following (table 2) contrasts relational databases, pre-computed aggregate indicators, and olap cubes: nc catch: advancing public health analytics 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 table 2. comparison of database structures relational database pre-computed aggregate (indicator) olap cube identity? all records are identified. no records are identified. no records are identified. aggregation? these are event-level (fully disaggregated) data with specific values, such as mrn, dob, or cause of death. data are binned into ranges, but a single indicator typically allows only one column to vary, e.g., death rate by age-band for a fixed location, time period, race(s), cause(s) of death. data are binned into ranges (that can be organized into hierarchies), but all dimensions can be explored in any combination, even mixing and matching hierarchy levels. big picture? must join multiple tables into a single, sparse matrix, but making sense of this is difficult. even simple domains require thousands of indicators to express the full nature of the problem. each cube is the big picture. a crucial advantage of this cube-like structure is the ability to extract arbitrary subsets very quickly. asking for everything related to any death record yields a subset (or "slice") that contains all of the pre-computed measures relating to this single death across all other characteristics such as age, race, and cause of death. asking for the intersection of all deaths belonging to 65-year-old whites produces the aggregates relating to this one specific age-ofdeath by race (the shaded area in figure 1). the principal advantage of having loaded the base transactional data into a data warehouse is that it allows the local health departments to sift-andsort through their data in a much more interactive -and much more natural -way than would have been possible through a traditional transaction-oriented data store. olap cubes can produce an answer for complex queries much faster than the same query on an online transaction processing (oltp) system. 18 multidimensional, event-level data. for simple, shallow, pre-computed reports, summary data aggregated at the county, region, or state level may suffice. to take full advantage of the exploratory capabilities that are provided by nc catch, however, requires having event-level data wherever possible, because the system cannot anticipate what level of analysis the end users wish to conduct. a mature platform for data exploration should allow its users to query data by geography, time, demographics, and data-set-specific properties such as disease, cause of death, birth weight, procedure performed, etc. this is what nc catch does, and it works best with data that are fully described; that is, entirely disaggregated. nc catch: advancing public health analytics 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 consider, for example, the various dimensions and measures which are available for inclusion in the typical hospital discharge (fact) data set: reporting year, reporting quarter, hospital number, type of admission, source of admission, discharge status, patient race, patient sex, patient zip code, principal diagnosis, secondary diagnoses, principal procedure, secondary procedures, principal payer, charges by revenue groups, drg code, patient age at admission, length of stay, day of week admitted, days from admission to procedure, patient county, facility county, and (in some states) attending and operating physician identification numbers. each dimension will have a set of hierarchical elements which themselves can be relatively coarse such as patient sex (i.e. male, female, unknown) or fine grained such as diagnosis (i.e. thousands of possibilities based upon the icd-9-cm coding system). the analytical potential of this extensive information is only available to the user who can access all of the detail and has the infrastructure to enable the analyses, as well as the knowledge and experience to exploit this potential for maximum insight. access to fine grained, event-level data, such as hospital discharge datasets, also makes it possible to utilize analytical software which has been developed by third parties (including government agencies) specifically to analyze this available information. nc catch, for example, utilizes a series of software tools that are available without cost from the agency for healthcare research and quality (ahrq). the prevention quality indicators (pqis) are a set of measures to be used with inpatient discharge data to identify ambulatory sensitive conditions (asc) in discharges; i.e. conditions for which good outpatient care can potentially prevent hospitalization or for which early intervention could prevent complications or more severe disease. although these indicators are based on hospital inpatient data, they are often used to provide insight into the community health care system or services outside the hospital setting. other ahrq indicator sets available in nc catch are the inpatient quality indicators (iqis) and the patient safety indicators (psis). the iqis are a set of measures that reflect quality of care inside hospitals including inpatient mortality for certain procedures and medical conditions; the utilization of procedures for which there are questions of overuse or underuse; and the volume of procedures for which there is evidence that higher volume is associated with lower mortality. a subset of the indicators is recommended for area-level utilization rate analysis. the psis are a set of indicators providing information on potential in hospital complications and adverse events following surgeries, procedures and childbirth. six of the indicators also have area level analogs and can be used to detect patient safety problems on a regional level, or for subpopulations defined in other ways. although commonly used in many static report card systems, summarized data that are aggregated from event level data have no analytical flexibility and are, therefore, of limited usefulness in interpreting the various relationships which influence population health status. an example of such an indicator is the hospitalization rate for ambulatory sensitive conditions (asc) per 1,000 medicare enrollees. this indicator aggregates all causes for an asc admission and provides data only for medicare, thus providing a very restricted view of preventable hospitalizations within any community. by contrast, with access to multiple years of event level hospital discharge data and the ahrq suite of analytical software, nc catch is able to derive the full analytical benefit from the asc construct – to understand avoidable hospitalizations for subgroups defined in multiple ways, e.g. by diagnosis, age, race, payer source, geographical nc catch: advancing public health analytics 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 location, pathway of hospitalization (scheduled or through the er), trends in the variables over time, and many other factors. the following screenshot (figure 2) shows a query which displays the distribution of four specific diabetes related types of avoidable hospitalizations within a single county, by gender and type of admission. with the ability to provide flexible alternative views of preventable hospitalizations, nc catch is able to model across dimensions, through hierarchies, and across members inside any population of interest. this flexibility enables the public health analyst to understand the nature of preventable hospitalizations as manifested uniquely in each community. figure 2. screenshot: diabetes related asc admissions by type and gender nc catch: advancing public health analytics 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 two levels of access. nc catch supports both anonymous public users and registered users (figure 3). figure 3. access architecture for nc catch anonymous users have access to the community profiles that summarize, by category, public health indicators relating to any county of their choice. these indicator groupings were composed by a committee of system users in order to enable the local analyst to select the category or categories of particular interest; e.g. overall mortality (shown), injury and violence, reproductive health and others. each selected group of indicators opens to a series of gauges which place the subject county value in reference to the state average and highest and lowest county values for each indicator (figure 4). these indicator values are contrasted with both the values of the county's peers -chosen specifically for each county on the basis of selected sociodemographic characteristics -and with the state values. there is some additional detail available to the users of this level of the system, such as thematic mapping for geographical granularity (census tract, community, county). the flexible customized views of the underlying data cubes (i.e. design phase) within the warehouse are restricted to registered users, giving them the ability to explore the data for deeper relationships and greater understanding. the process of becoming a registered nc catch user requires approval by the local health officer and the county administrator. nc catch: advancing public health analytics 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 figure 4. nc catch public access county profiles and indicator groupings operational governance and structure. all aspects of the nc catch system are directed by the schs working with an advisory committee composed of representatives from the schs, the office of healthy carolinians and health education (ohc), local public health directors and staff, and the uncc development team. the advisory committee sets the strategy for new development and incorporates modifications, as appropriate, based on user feedback on various aspects such as the look and feel of the interface, the grouping of various health measures into meaningful categories, and the content and conduct of training sessions. the advisory committee is responsible for maintaining a coherent vision of the nc catch system as it changes over time, and for determining that the maintenance and enhancement of the system is consistent with that strategic vision. the technical infrastructure is centralized to minimize development and maintenance costs, but the analytic capabilities are distributed and optimized locally. this enables even the smallest, resource poor local public health unit to have access to this powerful, flexible system. use of the hypercube aggregation model (olap) also addresses privacy concerns by allowing full analysis of event-level data while protecting the data itself. no event-level data is actually deployed; only the precomputed aggregates are populated for every combination of dimension cross sections. nc catch: advancing public health analytics 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 training. after the launch of phase 1 (county health profiles) in october 2008, the program was introduced to target users through a series of webinars. the webinars exposed the need for instruction and training particularly for the olap design phase. the ohc staff was tasked with the planning, designing and evaluation of the on-site trainings. health department staff and their healthy carolinians partners from all counties in north carolina were invited to one of 25 training sessions conveniently located throughout the state. training groups were limited to 15 or fewer participants. the five-hour trainings were composed of four modules: introduction to nc catch, understanding statistics, using the county health profile, and tailoring county reports. the “understanding statistics” section reviewed the basic statistics featured in nc catch and familiarized users with vocabulary and notations specific to the system. the last two modules focused on learning how to gather and interpret data through the system to meet cha needs and accreditation standards. during the training, participants completed both instructor-guided and independent exercises to practice creating useful data queries. for example, one exercise asked participants to examine and graph their county’s pregnancies by maternal age, allowing them to practice selecting and filtering many fields to find the answer to a relevant question in the design phase. ohc developed a training manual as a reference for the new user trainees that reviewed basic statistical concepts, the documentation available in the system (metadata) to aid data interpretation, and highlights of additional features available to the advanced user. pre and post training evaluations were administered to determine whether participants learned the basic concepts presented. in addition, each participant evaluated both the on-site and webinar trainings, so that the effectiveness of each training method could be compared. results from the tests and evaluations were reviewed weekly. trainings were modified when necessary, based on feedback from the training participants. nc catch training sessions were typically held at a computer lab or conference room in the local county health department or community college. between may and october 2009, over 200 health professionals from 83 out of 100 counties were trained on nc catch. most participants were health educators, although health directors, epidemiologists, program evaluators, and health policy staff also regularly attended the trainings. participants worked in priority areas including youth tobacco prevention, nutrition, childhood obesity, environmental health, hiv/std prevention, cancer prevention, women’s health, and substance abuse prevention. most participants had formal education in public health and qualitative data analysis; however, most had not had recent training in statistics and quantitative data interpretation. anonymous evaluations were used to determine the participants’ satisfaction with the training sessions and their reactions to the system itself. improvement and expansion of training opportunities for nc catch users continues to be a system priority. in person and online (webinar) training is now available. a hypertext help file is available online. video answers (screen video to frequently asked questions) are in the process of development. a formal user group has been established with regular feedback to the schs regarding system enhancements and training needs. nc catch: advancing public health analytics 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 future development issues the evolution of a distributed analytical environment for population health measurement and improvement is particularly dependent upon three major issues: data availability. a frequent complaint from public health decision makers is the paucity of hard data about the health status and behaviors of vulnerable subpopulations. however, the trend in most states is toward more, not fewer, restrictions on access to health outcome data. driven primarily by patient privacy concerns and in response to ever-more powerful data aggregation technologies, access to event-level data is becoming increasingly difficult. even pre-aggregated data is often suppressed. for instance, the cdc wonder data warehouse suppresses all mortality data where the total death count is less than six in counties of under 100,000 population and the time span is less than three years 19 . in north carolina, over 75% of the counties are under 100,000 population (2007 estimates). the desire to use patient encounter data for wider purposes undergirds such efforts as the agency for health care research and quality’s provider based population health initiative and the onc-it beacon communities program. the allure of gaining greater understanding of patient behaviors and the “meaningful use” mandate will require some accommodation of privacy concerns if data are to be utilized in anything approaching their true potential. the current default strategy is selective masking and total suppression. a more useful strategy is the practice of forcing aggregation until sufficient numbers of events and/or populations are covered. for instance, if a particular cause of death for a small geographical area for a single year, specific gender and particular race results in too few events to satisfy data identification concerns, aggregation across either time, race, gender, or years can be forced until sufficient numbers are achieved. for this approach to satisfy the needs of researchers and decision makers, however, the end user must be in control of the aggregation. evidence based practice. current thinking regarding population health status is oriented to the measurement model best typified by the national quality forum (nqf) measurement endorsement process, most successfully applied to healthcare structural, process, and outcome measures. 20 major limitations in this approach are apparent when attempting to apply this process to health status outcomes for geographically defined populations. evidence for community level interventions (in the form of programs and services) that will produce reliable and valid results across communities of varying sizes, sociodemographic composition, and other characteristics (measured and unmeasured) is sparse. the science of measuring healthcare performance has made progress in the last decade largely through rigorous evidence-based review, the development of risk-adjustment techniques and methods, and access to event-level clinical data. deployment of electronic health record technology is expected to accelerate this ability to measure healthcare services and outcomes. by contrast, public health practice has been largely bypassed by the advances in modern information technology: event-level data is difficult to access; no model of comprehensive community risk adjustment has been validated; and the local public health unit, with rare big city exceptions, has limited analytical infrastructure with which to determine local priorities or evaluate the impact of programs and services. nc catch: advancing public health analytics 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 information technology. the existence of the catch infrastructure opens up the possible utilization of many methodologies and technologies which can enhance the system, among them data mining and non-linear pattern recognition. one area of particular promise is visual analytics which is the science of analytical reasoning facilitated by visual interactive interfaces. visual analytics is most useful in situations which are complex and where the need for closely coupled human and computer analytics may make them otherwise infeasible; for example, where one is trying to determine the varying contribution of community racial composition on a large number of multiple outcomes such as many specific causes of mortality. these techniques hold the promise of providing the ability to analyze large and complex datasets rapidly either independently or as a screening precursor to traditional computational analysis. conclusions the shortcomings of the system of local public health units in the united states have been well documented: lack of modern information technology, an aging workforce in need of training, declining public financial support, and the lack of a clear vision about its role. the performance measurement initiative taking place in the healthcare system has not been replicated with similar urgency in public health; program evaluation is rare, the evidence base for public health practices is growing but still sparse, and population outcomes are neglected. 21 advances in information technology and software development have made it cost-effective to provide powerful and flexible analytic capability to local public health units. this important infrastructure for evolving an analytical culture for public health is also a necessary component for measuring and improving population health. acknowledgements the nc catch system has been supported by development and maintenance contracts from the nc division of public health. a grant from the kate b. reynolds charitable trust supported the original system deployment. nc catch: advancing public health analytics 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 references 1) institute of medicine: summary of recommendations, in waterfall w (ed): the future of public health. washington, dc, national academy press, 1988; 7-9. 2) institute of medicine: measurement tools for a community health improvement process, in: durch j. bailey l, stoto m (eds): improving health in the community: a role for performance monitoring. washington, dc, national academy press, 1997; 126. 3) institute of medicine: healthy communities: new partnerships for the future of public health. washington, dc, national academy press, 1996. 4) green lw. patch: cdc’s planned approach to community health, an application of preceed and an inspiration for proceed. j health educ. 1992; 23(3): 140-147. 5) us department of health and human services. healthy people 2000: national health promotion and disease prevention objectives. washington, dc: us government printing office; 1991. 6) perrin eb, koshel jj, eds, panel on performance measures and data for public health performance partnership grants, national research council. assessment of performance measures for public health, substances abuse and mental health. washington, dc, national academy press; 1997. 7) national association of county and city health officials. assessment protocol for excellence in public health. washington, dc, 1991. 8) fielding je, sutherland ce, halfon n. community report cards: results of a national survey. am j prev med. 1999; 17(1): 79-86. 9) www.countyhealthrankings.org. 10) wolfson, michael c., notes on measurement and accountability, presentation to iom committee on public health strategies to improve health meeting two, january 2010, http://iom.edu/~/media/files/activity%20files/publichealth/phstrategies/meeting%202/wo lfson2.pdf 11) studnicki j, steverson b, meyers b, et. al. a community health report card: comprehensive assessment for tracking community health (catch). best pract benchmarking healthc. 1997; 2(5): 196-207. 12) studnicki j, berndt d, luther s. hispanic health status in orange county, florida. j public health manag pract. 2005; 11(4): 326-332. 13) studnicki j, gipson l, fisher j, et. al. special healthcare taxing districts: association with population health status. am j prev med. 2007; 32(2): 116-123. 14) berndt d, fisher jw, craighead jg, et. al. the role of data warehousing in bioterrorism surveillance. decision support systems. 2007; 43: 1383-1403. 15) studnicki j, luther sl, kromrey j, et. al. a minimum data set and empirical model for population health status assessment. am j prev med. 2001; 20(1): 40-49. 16) ehealthinitiative.org. “national progress report”. 7 dec 2010 17) office of the national coordinator for health information technology. “hit_strategic_framework_2010-05-10.pdf”. 7 dec 2010. ../../../../jstudnic/local%20settings/temporary%20internet%20files/content.outlook/uxitgqsa/www.countyhealthrankings.org http://iom.edu/~/media/files/activity%20files/publichealth/phstrategies/meeting%202/wolfson2.pdf http://iom.edu/~/media/files/activity%20files/publichealth/phstrategies/meeting%202/wolfson2.pdf nc catch: advancing public health analytics 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.2, no. 3, 2010 18) chaudhuri s, umeshwar d. an overview of data warehousing and olap technology. sigmod rec. 1997. (acm)26: 65. doi: 10.1145/248603.248616.http://doi.acm.org/10.1145/248603.248616. 19) center for disease control. “compressed mortality file 1979-1998 and 1999-2007”. 7 dec 2010. 20) national quality forum. the abcs of measurement. nqf, washington, dc 20005. www.qualityforum.org. 21) jacobson pd, gostin lo. restoring health to health reform. jama. 2010; 304(1): 85-86. correspondence: james studnicki, sc.d. irwin belk endowed chair and professor 1 jstudnic@uncc.edu phone: 704-687-8981 fax: 704-687-6122 http://www.qualityforum.org/ layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts localized cluster detection applied to joint and separate military and veteran subpopulations howard burkom*1, yevgeniy elbert1, carla winston2, julie pavlin3, cynthia lucero-obusan2 and mark holodniy2 1johns hopkins applied physics laboratory, laurel, md, usa; 2office of public health surveillance research, veterans health administration, palo alto, ca, usa; 3armed forces health surveillance center, silver spring, md, usa objective we examined the utility of combining surveillance data from the departments of defense (dod) and veterans affairs (va) for spatial cluster detection. introduction the joint va/dod biosurveillance system for emerging biological threats project seeks to improve situational awareness of the health of va/dod populations by combining their respective data. each system uses a version of the electronic surveillance system for early notification of community-based epidemics (essence); a combined version is being tested. the current effort investigated combining the datasets for disease cluster detection. we compared results of retrospective cluster detection studies using both separate and joined data. — does combining datasets worsen the rate of background cluster determination? — does combining mask clusters detected on the separate datasets? — does combining find clusters that the separate datasets alone would miss? methods cluster determination runs were done with a spatial scan statistics implementation previously verified [1] by comparison with satscan software [2] using dod data from the biosense system. input data files were extracted from a repository of outpatient records from both dod and va facilities covering 4 years beginning jan. 1, 2007. this repository includes over 37 million dod records and over 86 million va records. input files were matrices of daily influenza-like-illness (ili) or gastrointestinal (gi) visit counts. matrix rows were consecutive days, columns were patient residence zip codes, and entry (i, j) was the number of visits on day i from with zip code j. these files were made for dod data, va data, and combined data. for assessing the alerting burden from combining datasets, three sets of runs were executed using data from three regions, baltimore/washington d.c. (dominated by dod data), los angeles (mainly va data), and tampa (representation of both). for each region, sets of 1672 daily runs were executed for ili and gi syndrome data. lastly, focused runs were done to investigate known outbreaks in new york (gi, jan-mar 2010), san diego (ili, dec 2007-apr 2008 and fall 2009), and new jersey (gi, jan-mar 2010). results combining the data sources increased the rate of significant cluster alerting by a manageable 1-10% across run sets. some clusters found only when the data were combined persisted over several days and may have indicated small events not reported in either system; however, we were unable to validate minor events that may have occurred in past years. retrospective looks at known outbreaks were successful in that clustering evidence found in separate dod and va runs persisted when data sets were combined. for the new york run, a west point outbreak was seen in repeated clusters of combined data, beginning days before the event report. however, clustering did not consistently produce alerts before outbreak report dates. in the new jersey dod runs, repeated clusters indicated a 10-week gi outbreak at fort dix; adding va data that dominated the record counts gave the same clusters with no added cases, so the dod event was probably self-contained. the san diego runs were aimed at detecting unusually severe influenza epidemics in february 2008 and in the fall of 2009, and numerous clusters were found but did not enhance regional disease tracking. conclusions from the analysis, combining dod and va data enhances cluster detection capability without loss of sensitivity to events isolated in either population and with manageable effect on the customary alert rate. for cluster detection, there may be many geographic regions where a health monitor in one of the systems would benefit from combined data. more detailed outbreak information is needed to quantify the timeliness/sensitivity advantages of combining datasets. in events examined, clustering itself yielded an occasional but not consistent timeliness advantage. keywords essence; department of defense; scan statistics; cluster detection; veterans administration references [1] xing j, burkom h, moniz l, edgerton j, leuze m, and tokars j. evaluation of sliding baseline methods for spatial estimation for cluster detection in the biosurveillance system, international journal of health geographics 2009, 8:45 [2] satscan: software for the spatial, temporal, and space-time scan statistics. www.satscan.org (last accessed 20aug2012) *howard burkom e-mail: howard.burkom@jhuapl.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e10, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts s&i public health reporting initiative: improving standardization of surveillance michael coletta*1, nikolay lipskiy2, david birnbaum3 and john abellera2 1naccho, washington, dc, usa; 2cdc, atlanta, ga, usa; 3washington state department of health, olympia, wa, usa objective the objective of this panel is to inform the isds community of the progress made in the standards & interoperability (s&i) framework public health reporting initiative (phri). also, it will provide some context of how the initiative will likely affect biosurveillance reporting in meaningful use stage 3 and future harmonization of data standards requirements for public health reporting. introduction the s&i framework is an office of national coordinator (onc) initiative designed to support individual working groups who focus on a specific interoperability challenge. one of these working groups within the s&i framework is the phri, which is using the s&i framework as a platform for a community-led project focused on simplifying public health reporting and ensuring ehr interoperability with public health information systems. phri hopes to create a new public health reporting objective for meaningful use stage 3 that is broader than the current program-specific objectives and will lay the ground work for all public health reporting in the future. to date, the initiative received over 30 descriptions of different types of public health reporting that were then grouped into 5 domain categories. each domain category was decomposed into component elements and commonalities were identified. the phri is now working to reconstruct a single model of public health reporting through a consensus process that will soon lead to a pilot demonstration of the most ready reporting types. this panel will outline progress, challenges, and next steps of the initiative as well as describe how the initiative may affect a standard language for biosurveillance reporting. methods michael coletta will provide an introduction and background of the s&i phri. he will describe how the phri intends to impact reporting in a way that is universal and helpful to both hit vendors and public health programs. nikolay lipskiy will provide an understanding of the ground breaking nature of collaboration and harmonization that is occurring across public health programs. he will describe the data harmonization process, outcomes, and hopes for the future of this work. david birnbaum has been a very active member of phri and has consistently advocated for the inclusion of healthcare associated infections (hai) reporting in meaningful use as a model. david has been representing one of the largest user communities among those farthest along toward automated uploading of data to public health agencies. he will describe the opportunities and challenges of this initiative from the perspective of a participant representing an already highly evolved reporting system (cdc’s national healthcare safety network system). john abellera has been the steward of the communicable disease reporting user story for the phri. he will describe the current challenges to reporting and how the phri proposed changes could improve communicable disease reporting efforts. this will be followed by an open discussion with the audience intended to elicit reactions regarding an eventual consolidation from individual report specific specification documents to one core report specification across public health reporting programs which is then supplemented with both program specific specifications and a limited number of implementation specific specifications. results plan to engage audience: have a prepared list of questions to pose to the audience for reactions and discussion (to be supplied if participation is low). keywords standards; interoperability; meaningful use; reporting; stage 3 *michael coletta e-mail: mcoletta@naccho.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e100, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts time of arrival analysis in nc detect to find clusters of interest from unclassified patient visit records meichun li*1, wayne loschen2, lana deyneka3, howard burkom2, amy ising1 and anna waller1 1emergency medicine, unc chapel hill, chapel hill, nc, usa; 2johns hopkins university applied physics laboratory, laurel, md, usa; 3north carolina division of public health, raleigh, nc, usa objective to describe a collaboration with the johns hopkins applied physics laboratory (jhu apl), the north carolina division of public health (nc dph), and the unc department of emergency medicine carolina center for health informatics (cchi) to implement time-of-arrival analysis (toa) for hospital emergency department (ed) data in nc detect to identify clusters of ed visits for which there is no pre-defined syndrome or sub-syndrome. introduction toa identifies clusters of patients arriving to a hospital ed within a short temporal interval. past implementations have been restricted to records of patients with a specific type of complaint. the florida department of health uses toa at the county level for multiple subsyndromes (1). in 2011, nc dph, cchi and cdc collaborated to enhance and evaluate this capability for nc detect, using nc detect data in biosense 1.0 (2). after this successful evaluation based on exposure complaints, discussions were held to determine the best approach to implement this new algorithm into the production environment for nc detect. nc dph was particularly interested in determining if toa could be used for identifying clusters of ed visits not filtered by any syndrome or sub-syndrome. in other words, can toa detect a cluster of ed visits relating to a public health event, even if symptoms from that event are not characterized by a predefined syndrome grouping? syndromes are continuously added to nc detect but a syndrome cannot be created for every potential event of public health concern. this toa approach is the first attempt to address this issue in nc detect. the initial goal is to identify clusters of related ed visits whose keywords, signs and/or symptoms are not all expressed by a traditional syndrome, e.g. rash, gastrointestinal, and flu-like illnesses. the goal instead is to identify clusters resulting from specific events or exposures regardless of how patients present – event concepts that are too numerous to pre-classify. methods in late 2011, nc dph and jhu apl signed a software license agreement and soon thereafter cchi received the toa software package. in may 2012, the toa controller was adapted and set up to run against ed visit data for all nc detect hospitals. the toa looks for clusters in all ed visits by hospital based solely on arrival time in both 30-minute and 60-minute intervals. there is no pre-classification of the chief complaints or triage notes into syndromes. toa alerts are viewable on the nc detect web application and, as of august 2012, users are able to document any actions taken on these alerts. results from april 15, 2012 to july 31, 2012, toa generated 173 alerts across all 115 hospitals reporting to nc detect. the toa identified a group of scabies-related ed visits that was not captured in another syndrome. the toa also identified clusters identified by hospitals as disaster-related which included misspellings that had not been previously identified, e.g. “diaster” and “disater,” as well as events involving out-of-town groups that will not be identified spatially (table 1). this preliminary review of toa alerts did not evaluate toa for false negatives. conclusions our preliminary review of toa shows that this algorithm approach can be helpful for identifying clusters of ed visits that are not captured by existing syndromes and can be used to identify hospital coding schemes for disaster events. the toa will continue to be monitored in our production environment and evaluated for additional effectiveness. we will also explore tools that will display counts of terms within a toa alert to assist in signal investigation. table 1: sample clusters detected with toa analysis keywords cluster detection; time-of-arrival analysis; syndrome classification references 1. burkom h, loschen w, kite-powell a et al. a collaboration to enhance detection of disease outbreaks clustered by time of patient arrival, presented at the international society for disease surveillance, 2010 annual conference, park city, utah, dec 2, 2010 2. deyneka l, xu z, burkom h, hicks p, benoit s, vaughan-batten h, ising a. finding time-of-arrival clusters of exposure-related visits to emergency departments in contiguous hospital groups. emerging health threats journal 2011, 4: 11702 doi: 10.3402/ehtj.v4i0.11702 *meichun li e-mail: mcli@email.unc.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e13, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts an improved algorithm for outbreak detection in multiple surveillance systems angela noufaily*1, doyo enki1, paddy farrington1, paul garthwaite1, nick andrews2 and andre charlett2 1the open university, milton keynes, united kingdom; 2health protection agency, london, united kingdom objective to improve the performance of the england and wales large scale multiple statistical surveillance system for infectious disease outbreaks with a view to reducing the number of false reports, while retaining good power to detect genuine outbreaks. introduction there has been much interest in the use of statistical surveillance systems over the last decade, prompted by concerns over bio-terrorism, the emergence of new pathogens such as sars and swine flu, and the persistent public health problems of infectious disease outbreaks. in the united kingdom (uk), statistical surveillance methods have been in routine use at the health protection agency (hpa) since the early 1990s and at health protection scotland (hps) since the early 2000s (1,2). these are based on a simple yet robust quasi-poisson regression method (1). we revisit the algorithm with a view to improving its performance. methods we fit a quasi-poisson regression model to baseline data. one of the limitations of the current algorithm is the small number of baseline weeks used. we propose a simple seasonal adjustment using factors. we extend the model to include a 10-level factor. we fit the trend component always irrespective of its statistical significance. we are concerned that the existing weighting procedure is too drastic. the baseline at a certain week is down-weighted if the standardized anscombe residual for that week is greater than 1. this condition was chosen empirically to avoid reducing the sensitivity of the system in the presence of large outbreaks in the baselines, but may be increasing the fpr unduly when there are no or only small outbreaks in the baselines. we investigate several other options, including reducing the down-weighting to cases where the anscombe residuals are greater than 2 or 3. we evaluate a new re-weighting scheme informed by past decisions. using this adaptive scheme, baseline data where an alarm was flagged are down-weighted to reduce their effect on current predictions. the criterion we use for re-weighting, here, is the value of the exceedance score. finally, we investigate the validity of the upper threshold values based on the quasi-poisson model when the data are generated using known negative binomial distributions. results our evaluation of the existing algorithm showed that the false positive rate (fpr) is too high. a novel feature of our new models is that they make use of much more baseline data. this resulted in a better estimation of the trend and variance and decreased the fpr. in addition, we found that the trend should always be fitted even when non-significant (or extreme). this decreases the discrepancies in the results when moving from one week to another. the adaptive reweighting scheme was found to give broadly equivalent results to the reweighting method based on scaled anscombe residuals. using the latter as in the original hpa method, but with much higher threshold for reweighting decreased the fpr further. our investigations also suggest that the negative binomial model is a reasonable one, though not ideal in all circumstances. thus, there is a good case for replacing the quasi-poisson model with the negative binomial. one of the unusual features of the hpa system is that it is run every week on a database of more than 3300 distinct organisms, which is likely to produce a large number of aberrances. we found that retaining the exceedance score approach based on the 0.995 quantile is perfectly reasonable. this involves ranking aberrant organisms in order of exceedance. conclusions we have undertaken a thorough evaluation of the hpa’s outbreak detection system based on simulated and real data. the main conclusion from this evaluation is that the fpr is too high, owing to a combination of factors notably excessive down-weighting of high baselines and reliance on too few baseline weeks. keywords outbreak; negative binomial regression; quasi-poisson acknowledgments this research was supported by a project grant from the medical research council, and by a royal society wolfson research merit award. references 1. farrington cp, andrews nj, beale aj, catchpole ma. a statistical algorithm for the early detection of outbreaks of infectious disease. journal of the royal statistical society series a. 1996; 159: 547-563. 2. mccabe gj, greenhalgh d, gettingby g, holmes e, cowden j. prediction of infectious diseases: an exception reporting system. journal of medical informatics and technologies. 2003;5: 67-74. *angela noufaily e-mail: a.noufaily@open.ac.uk online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e148, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts state and local health agency engagement in hie: a cross-sectional survey brian e. dixon*1, 2, 3, roland e. gamache1, 2 and shaun j. grannis4, 2 1school of informatics, indiana university, indianapolis, in, usa; 2regenstrief institute, indianapolis, in, usa; 3center of excellence on implementing evidence-based practice, department of veterans affairs, veterans health administration, health services research and development service, indianapolis, in, usa; 4indiana university school of medicine, indianapolis, in, usa objective to characterize state and local health agency relationships with health information exchange organizations. introduction there is growing interest in leveraging available health information exchange (hie) infrastructures to improve public health surveillance (1). the health information technology for clinical and economic health act and meaningful use criteria for electronic health record (ehr) systems are among the factors driving the development, adoption and use of hies. hies deliver or make accessible clinical and administrative data as patients are admitted, discharged, and transferred across hospitals, clinics, medical centers, counties, states and regions (2). while several hie infrastructures exist (3), there is little evidence on the engagement in hie initiatives by state and local health agencies. methods an online survey of state and local health officials was conducted in six states where hies were known to be present. half of the states were funded by the centers for disease control and prevention (cdc) to engage public health agencies in hie activities; the other half received no such funding. a total of 143 officials were invited to participate; 73 (51%) responded. the survey asked respondents about their agencies awareness, engagement, and data exchange with hies. the survey further asked agencies about their perceptions of barriers and challenges to public health engagement with hie organizations. results just 25% of agencies had a formal relationship, typically created through a memorandum of understanding or data usage agreement, with at least one nearby hie. the majority (54%) of agencies either had no relationship (20%) or only an informal relationship (34%) with an hie. the remaining agencies (18%) reported that no hie existed in their jurisdiction. agencies in states that had received cdc funding for hie engagement were more likely (14 versus 2) to be formally partnered with an hie. conclusions few public health agencies are formally engaged in hie. financial costs, human resources, and concerns regarding privacy/security were the top cited barriers to broader engagement in hie. for public health to be an active participant in and reap the benefits of hie, greater investment in state and local public health informatics capacity, including human resources, and education regarding hie privacy and security practices are needed. keywords health information exchange; electronic laboratory reporting; public health surveillance; public health informatics acknowledgments this work was supported, in part, by the indiana center of excellence in public health informatics through a grant from the cdc (501hk000077). references 1. savel tg, foldy s. the role of public health informatics in enhancing public health surveillance. mmwr surveill summ. 2012;61:204. 2. dixon be, zafar a, overhage jm. a framework for evaluating the costs, effort, and value of nationwide health information exchange. j am med inform assoc. 2010;17(3):295-301. 3. ehealth initiative. the state of health information exchange in 2010: connecting the nation to achieve meaningful use. washington, dc2010 [cited 2010 september 29]; available from: http://ehealthinitiative.org/uploads/file/final%20report.pdf. *brian e. dixon e-mail: bdixon@regenstrief.org online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e105, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts incorporation of school absenteeism data into the maryland electronic surveillance system for the early notification of community-based epidemics (essence) zachary faigen*, anikah salim and isaac ajit office of preparedness & response, maryland department of health and mental hygiene, baltimore, md, usa objective the state of maryland has incorporated 100% of its public school systems into a statewide disease surveillance system. this session will discuss the process, challenges, and best practices for expanding the essence system to include school absenteeism data as part of disease surveillance. it will also discuss the plans that maryland has for using this new data source, as well as the potential for further expansion. introduction syndromic surveillance offers the potential for earlier detection of bioterrorism, outbreaks, and other public health emergencies than traditional disease surveillance. the maryland department of health and mental hygiene (dhmh) office of preparedness and response (op&r) conducts syndromic surveillance using the electronic surveillance system for the early notification of community-based epidemics (essence). since its inception, essence has been a vital tool for dhmh, providing continuous situational awareness for public health policy decision makers. it has been established in the public health community that syndromic surveillance data, including school absenteeism data, has efficacy in monitoring disease, and specifically, influenza activity. schools have the potential to play a major role in the spread of disease during an epidemic. therefore, having school absenteeism data in essence would provide the opportunity to monitor schools throughout the school year and take appropriate actions to mitigate infections and the spread of disease. methods dhmh partnered with the maryland state department of education (msde), local health departments, and local school systems to incorporate school absenteeism data into the syndromic surveillance program. there are 24 local public school systems and 24 local health departments in the state of maryland. op&r contacted each local school superintendent and each local health officer to arrange a joint meeting to discuss the expansion of the essence program to include school absenteeism data. once the meetings were arranged, op&r epidemiologists traveled to each local jurisdiction and presented their plan for the essence expansion. at each meeting were representatives from the local health department, as well as school health, school attendance, and school it staff. this allowed all questions and concerns to be addressed from both sides. in addition to the targeted meetings and presentations, the secretary of health issued an executive order which required all local school systems to sign a memorandum of understanding (mou) with dhmh. this mou detailed the data elements to be shared with the essence program and the process by which this would be shared. while this order made data contribution mandatory, the site visits by the op&r staff created a working relationship and partnership with the local jurisdictions. data was collected from all public schools in the state including elementary, middle, and high schools. results as of june 30, 2012, maryland became the first state in the united states to incorporate 100% of its public school systems (1,424 schools) into essence. each school system reports absenteeism data daily via an automated secure ftp (sftp) transfer to dhmh. due to its unique properties, johns hopkins applied physics laboratory (jhuapl) designed a new detection algorithm in essence specifically for this data source. op&r epidemiologist review and analyze this data for disease surveillance purposes in conjunction with other data sources in essence (emergency department chief complaints, poison control center data, thermometer sales data, and over-the-counter medication sales data). integrating school absenteeism data will provide a more complete analysis of potential public health threats. the process by which maryland incorporated their public school systems’ data could potentially be used as a best practice for other jurisdictions. not only was dhmh able to obtain data from all public schools in the state, but the process also enhanced collaboration between local health departments and public school systems. keywords essence; surveillance; absenteeism acknowledgments the office of preparedness & response at the maryland department of health and mental hygiene would like to acknowledge and thank the maryland state department of education and the 24 local health departments and public school systems for their support and collaboration to successfully implement this project. *zachary faigen e-mail: zfaigen@dhmh.state.md.us online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e176, 2013 a web-based system for mapping laboratory networks: analysis of gladmap application 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 a web-based system for mapping laboratory networks: analysis of gladmap application shamir n mukhi 1 , kashmeera meghnath 2 , theodore i kuschak 1 , may chu 3 , lai king ng 1 1 national microbiology laboratory, public health agency of canada 2 university of saskatchewan, canada 3 centres for disease control and prevention, usa abstract public health emergencies such as h1n1 and sars pandemics have demonstrated and validated the necessity of a strong and cohesive laboratory response system that is able to respond to threats in an efficient and timely manner. individual laboratories, through connection with other laboratories or networks, are able to enhance their capacity for preparedness and response to emergencies. efficient networks often establish standards and maintain best practices within member laboratories. the global laboratory directory mapping tool (gladmap) supports the efforts of laboratory networks to improve their connectivity by providing a simple and efficient tool to profile laboratories by geographic location, function or expertise. the purpose of this paper is to evaluate the effectiveness of the gladmap search tool and the completeness of the descriptive content of networks and laboratories that are currently contained within the gladmap database. we determined the extent of information volunteered and how the system is being used. although the system aims to attract an array of users from around the globe, our analysis reveals minimal participation and information sharing and that the low profile participation rate limits the tool’s functionality. the global laboratory directory platform has addressed barriers to participation by adding optional functionality such as restricted access to laboratory profiles to protect private information and by implementing additional functional applications complementary to gladmap. keywords: laboratory, informatics, web-based, mapping, networks background one essential function of public health laboratories is to identify etiologic agents of disease in an accurate and timely manner. international health regulations 2005 [1] were established to facilitate the reporting and dissemination of public health emergencies of global concerns through the world health organization (who). however, the practicality and potential of these laboratories in the detection and monitoring of threats over a wide geographic range is limited by unclear case definitions, communication barriers, inadequate laboratory capacity, economic and political challenges as well as differing priorities of local authorities in meeting ihr recommendations. establishing and sustaining global, regional, and local laboratory networks serves to alleviate numerous technical challenges by sharing resources to complement individual laboratories’ capabilities and capacities. http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 laboratory networking is the key to establishing and maintaining operational standards, and for advancing technologies for disease detection and confirmation. networks do this by facilitating member laboratories’ standardization of testing and reporting procedures, and through provision of reagents, equipment, training, reference materials, quality control indicators, and other forms of support [2,3]. networking or collaboration between and among laboratories over time builds trust and affords rapid and accurate information sharing during an outbreak. networking enables the sharing of information about the magnitude of outbreaks and the responsible strains that are circulating in particular regions, leading to faster response and more targeted and effective control of the threat, while still respecting inter-jurisdictional policies. currently 10% of research funding goes towards challenges faced by 90% of the population [4] and is referred to as the 10/90 gap. health security in developing countries is impeded by the poor capacity for locally or nationally available research and by limited access to the relevant research occurring abroad [4,5]. developing countries also face “digital” and “knowledge” divides due to inadequate access to the same resources and knowledge available to developed countries. networking and international collaborations could bridge this gap through long-term partnerships between local and global institutions to provide comparable expertise to local institutions and access to up-to-date information. the global laboratory directory (glad) concept was developed in response to the international health regulations (ihr) 2005 revision, which called for the strengthening of core capacities and enhanced international collaboration to mitigate the spread of diseases. glad is a collaboration among the world health organization, the national microbiology laboratory (public health agency of canada), and the centers for disease control and prevention (usa). glad strives to connect laboratory networks and their member laboratories to a global peer network. glad acts as a social networking support system for laboratories world wide to facilitate enhanced communication, capabilities, and capacities in order to increase emergency preparedness and response. the global laboratory directory concept is comprised of three components; gladresource, gladsupport, and gladmap [6]. in this paper, we focus on gladmap, developed by the public agency of canada. its database currently holds laboratory profiles of some of the networks and national reference laboratories. gladmap overview the gladmap component provides an intuitive, multi-faceted search engine and visual display of the interactive relationships among networks and their member laboratories. gladmap uses a visualization tool that displays information provided by the network and its member laboratories. it enables users to: (1) find laboratories or networks that are dedicated to a specific objective or function, (2) connect with those located in geographical locations of interest, and (3) search for providers of specific type(s) of services and expertise/experts. gladmap consists of three fundamental hierarchical information units: 1) laboratory, 2) institution and 3) network. a laboratory is defined as a place (room, building or facility) set http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 apart for a group of scientists to conduct applied investigations in science (e.g. bacteriology, virology, toxicology, parasitology) or production of reagents for such investigations (animal facility, media preparation) and analysis and interpretation of results (e.g. bioinformatics, biostatistics, mathematical modeling) from undertaking the investigations. a laboratory can be complex and multi-faceted or very simple (e.g, set up for basic sample collection as its sole function). a laboratory is the most basic information unit within the gladmap system. users can define a laboratory’s relationship with their networks and/or institutions. the second information unit within gladmap is an institution, which is defined as an organization established to provide public services. it houses one or more laboratory units that are the official workspaces of scientists and principal investigator(s) where they perform scientific work. an institution is a legal entity that has an official designation that gives them the mandate or authority to house the laboratory units. any number of laboratory units may or may not be co-located within the same institution. the third information unit within the gladmap system is a network, which is defined as an interconnected entity (usually championed by a "leader" or "manager") and linked by common interest (a community of practice). members develop a working relationship for professional benefit and visibility. networks are often established to achieve common goals that are accomplished more easily together than by one or two entities on their own. networks may have formal or informal organizational and administrative structures and may also collaborate together to form networking alliances through formal or informal agreements. for example, the canadian public health laboratory network (cphln) and the association for public health laboratories (aphl) in the united states share a memorandum of understanding. methodology to determine the status of network-related information available on gladmap, each network’s public website was accessed in order to locate a listing of member laboratories [8-20]. the public listing was then compared to the laboratories listed in gladmap to determine if information gaps existed. in a number of cases, the website provided a total number of laboratories but did not list them individually. in these cases, if the number of laboratories on the website exceeded the number in gladmap, it was concluded that gaps existed; and if there were fewer laboratories publicly listed than available on gladmap, it was deemed inconclusive since there was no way to compare the individual laboratories. all network websites were accessed between may 23, 2011 and may 31, 2011. the remainder of the analysis was completed using data collected on june 7, 2011. this included data regarding profile completion of each laboratory, search function data for each laboratory, search keywords and the originating ip address of each search. laboratory profile completion was analyzed to determine how many of the laboratories listed in glad had completed their profiles. this was done by organizing laboratory profiles by network and defining all the profiles that had more than half of the optional fields filled in as being considered completed. to determine the correlation between profile completion and profile search function access, data regarding the number of times each laboratory appeared in the http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 search results (“found”) and the number of times each profile was accessed from the search results (“clicked”) was used. the profile completion rates were determined for the most commonly “found” and “clicked” profiles and were compared to the overall “found” and “clicked” rates in order to determine if any relationship existed. the gladmap search function allows a user to perform searches by network, country, who region, laboratory name, contact name, affiliated institution, or test. to determine the most commonly used search field, the search keywords from all queries run between october 2009 and april 2011 were sorted into each of the previous categories. if the context of the search keyword was ambiguous, it was categorized as “other”. the number of searches for each category was summed to determine the most commonly used search fields. it was also important to determine the origin of the search terms in order to understand who is using the system. to determine the geographic location of gladmap users, ip address information for each search query was used. the location of the ip address associated with each individual search term was identified using the website ip-lookup.net, and the number of searches per country was organized by who region. to determine whether different geographic regions used gladmap differently, search keywords from each who region were again categorized by field (network, country, who region, laboratory name, contact name, affiliated institution, or test) and the number of searches by each field was summed for each who region. the african and eastern mediterranean regions were omitted from the results due to insufficient data. results and discussion gladmap, at the time of analysis, contained 33 networks and 1,075 laboratories. the networks varied greatly in size, with each network containing between 0 and 200 member laboratories and affiliated institutions (figure 1) entered into the current database. the networks with 0 members are the result of networks that registered, but did not provide a membership list. http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 figure 1: affiliated laboratories and institutions per network when comparing the laboratory listings available in gladmap to the publicly available laboratory listings for each network, significant gaps were identified. of the 33 networks in gladmap, public laboratory listings or information about the total number of member laboratories were available for 14 networks. of these 14 networks, 11 contained laboratories not listed in gladmap, 2 contained no missing listings, and 1 was inconclusive (figure 2). figure 2: laboratory gaps in gladmap networks http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 laboratory profile completion is an extremely important aspect of gladmap since it increases the number of search terms that will include the laboratory in the search results. one of the most useful functions of gladmap is the ability for users to efficiently locate laboratories based on a specific function, but this ability hinges on the completeness of their profiles. overall, the completion rate of all the laboratories in gladmap was 9.8%. furthermore, only 10% of all laboratory profiles have ever been accessed through the search results. within these 10%, the profile completion rate is 39.7% indicating that completed profiles are more likely to be found and accessed using the search function. figure 3 shows laboratory profile submission rates by network. this figure shows that of the 33 networks, only 5 are 100% complete, and 3 more are at least 50% complete. the majority of network profiles are incomplete, and therefore are not searchable by function. figure 3: laboratory profiles by networkcomplete and total notably, thailand has two regional networks listed in gladmap with complete or nearly complete laboratory profiles. similarly, the largest network with a complete set of profiles is red nacional de laboratorios de salud pública (rnlsp), a network of 29 local public health laboratories in mexico. national public health networks may have higher profile completion rates because they are smaller in size with a more central governance structure compared to some http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 of the larger international networks. the 10-member who human papilloma virus (hpv) network profile is also complete. search function usage statistics were analyzed to gather demographic information about who is using the system and how they are using it. search function data including keywords and ip addresses were analyzed to determine the origin of gladmap searches and users’ preferred fields and search terms. there have been 1463 searches originating from 42 countries. the top 3 countries using gladmap are switzerland, canada and the united states. it is apparent that the european and american who regions are by far the greatest users of the system, mostly due to the heavy use from canada, switzerland and the united states (figure 4). figure 4: gladmap searches by who region analysis of search field usage was also conducted in order to determine how the search function was being employed (figure 5). using 2565 search terms it was determined that the most common search was by network name, followed by test type, country, who region, laboratory name, and institution. the large number of test type searches is significant, because, as mentioned previously, only those labs with completed profiles will appear in the search results for this field. http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 figure 5: global search field usage (n=2565) search field usage was also examined for each who region (figure 6). for all the regions, network was the most commonly used search term. use of the other fields varied across the regions. sample sizes for the southeast asian and western pacific regions were significantly smaller than the american and european regions, thus results from these regions may be less accurate. figure 6: search field usage by who region http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 limitations one of the limitations currently facing gladmap is the large number of incomplete profiles. the ability to search for labs by the test that they perform is a key function expected of the system. for gladmap to be a useful tool for networking and surveillance a greater degree of participation is required from the individual laboratories; they will need to take the time to fill out their profiles. low profile completion rate may be due to many factors, such as: (i) different laboratories have varying level of comfort in offering information to a new social network; (ii) some fields are not applicable to them; (iii) members need further clarification of utility of information; (iv) it takes time to buy in, but they expect to volunteer more in the future; (v) potential duplication of data entry; (vi) institutions may have policies on posting information on a public site, so individual laboratory units may have difficulty in completing profiles. until the recent past, there were no security settings to protect profile information within the application. gladmap now includes a feature that allows profiles to be either publicly available or made secure. some laboratories had expressed privacy concerns; securing the profiles may foster an increase in the completed profiles. another limitation is incomplete networks within the system. that is, networks with missing laboratories. reasons for these may include: (i) some networks are complex and large so it will take time for a network manager to contact members who may have different priorities; (ii) uncertainty by individual laboratories on the objectives and intent of the gladmap project; (iii) individual laboratories require approval from authorities; (iv) language barriers; and (v) unclear of ownership of the web database and its long term support. furthermore, more than half of the national public health laboratories in the world are not associated with networks. in order to achieve this, a catergory “does not belong to network” was created under networks for a quick search. it is important to capture them into the application so that they become visible and to have an opportunity to be invited for collaboration or networking. conclusion the global laboratory directory provides a platform for laboratory networks to unite experts and exchange knowledge in order to collectively work towards global health security. providing support for laboratory networks plays an important and direct role in the eradication of disease, as increased regional or global collaboration facilitates faster response and more effective control of global health threats. from the search usage statistics, it is apparent that the system is primarily being used by switzerland, canada, and the us, countries that are home to glad’s partners at the who, phac, and cdc, respectively, indicating that the creators of the system are the ones who are using it the most. gladmap would be of particular use to laboratories situated in middle to lowincome countries, where it can be used to interact with laboratories around the globe in order to build capacity and strengthen response. http://ojphi.org/ a web-based system for mapping laboratory networks: analysis of gladmap application 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 additional support tools that provide users with the capability to share resources and interact with other users around the globe could be useful. we hope that the opportunity to partake in the global scientific community will attract users to contribute and participate in the global laboratory directory. acknowledgements the authors like to thank all who have participated in the pilots and provided information for the profiles on gladmap application. corresponding author shamir mukhi shamir.nizar.mukhi@phac-aspc.gc.ca references 1. baker, m.g. and fidler, d.p. global public health surveillance under new international health regulations. emerging infectious diseases. 2006;12:1058-65. 2. hull, b.p. and dowdle, w.r. poliovirus surveillance: building the poliovirus laboratory network. j infect dis. 1997;175(suppl):s113-6 3. featherstone, d., brown, d., and sanders, r. development of the global measles laboratory network. j infect dis. 2003;187(suppl 1):s264–9 4. al-tuwaijri, s., currat, louis j., davey, s., de francisco, a., ghaffar, a., jupp, s., mauroux, c. the 10/90 report for health research 20032004. switzerland: global forum for health research. 2004. 5. harris, e. building scientific capacity in developing countries. embo reports. 2004;5:7-11. 6. mukhi, s.n., ng, l.k., kuschak, t.i. and chu, m. knowledge integration to support networking for laboratory preparedness and response to emerging pathogens, new research on knowledge management technology, huei-tse hou (ed.), isbn: 978-953-510074-4, intech, available from: http://www.intechopen.com/articles/show/title/knowledge-integration-to-supportnetworking-for-laboratory-preparedness-and-response-to-emerging-pat 7. wertheim, h.f.l., puthavathana, p., nghiem, n.m., van doorn, h.r., nguyen, t.v., et al. laboratory capacity building in asia for infectious disease research: experiences from the south east asia infectious disease clinical research network (seaicrn). plos medicine. 2010: 7. 8. association of public health laboratories (2010). aphl member laboratory listing [online]. available: http://www.aphl.org/aboutaphl/memberlabs/pages/default.aspx 9. canadian public health laboratory network (2010). cphln member organizations listing [online]. available: http://www.cphln.ca/organizations_eng.html http://ojphi.org/ mailto:shamir.nizar.mukhi@phac-aspc.gc.ca http://www.intechopen.com/articles/show/title/knowledge-integration-to-support-networking-for-laboratory-preparedness-and-response-to-emerging-pat http://www.intechopen.com/articles/show/title/knowledge-integration-to-support-networking-for-laboratory-preparedness-and-response-to-emerging-pat http://www.aphl.org/aboutaphl/memberlabs/pages/default.aspx http://www.cphln.ca/organizations_eng.html a web-based system for mapping laboratory networks: analysis of gladmap application 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * vol.4, no. 2, 2012 10. world health organization regional office for the western pacific. (2011). japanese encephalitis laboratory network [online]. available: http://www.wpro.who.int/health_topics/laboratory/jelab.htm 11. thai national influenza center (2011). thai nic, dmsc laboratory listing [online]. available: http://www.thainihnic.org/labnetwork.asp. 12. the global polio eradication initiative (2010). the global polio laboratory network. [online]. available: http://www.polioeradication.org/dataandmonitoring/surveillance/globalpoliolaboratorynet work.aspx 13. pulsenet international(2010). pulsenet asia pacific [online]. available: http://www.pulsenetinternational.org/networks/pages/asiapacific.aspx 14. pulsenet international (2010). pulsenet canada [online]. available: http://www.pulsenetinternational.org/networks/pages/canada.aspx 15. pulsenet international (2010). pulsenet latin america and caribbean [online]. available: http://www.pulsenetinternational.org/networks/pages/latinamerica.aspx 16. pulsenet association of public health laboratories (2010). aphl member laboratory listing [online]. available: http://www.aphl.org/aboutaphl/memberlabs/pages/default.aspx 17. pasteur international (2010). the institut pasteur international network [online]. available: http://www.pasteur-international.org/ip/easysite/pasteur-international-en/institut-pasteurinternational-network/the-network 18. world health organization (2011). national influenza centers [online]. available: http://www.who.int/csr/disease/influenza/centres/en/index.html 19. whonet (2011). whonet community [online]. available: http://www.whonet.org/dnn/whonetcommunity/tabid/63/language/en-us/default.aspx 20. whonet (2011). argentina [online]. available: http://www.whonet.org/dnn/whonetcommunity/argentina/tabid/62/language/enus/default.aspx. http://ojphi.org/ http://www.wpro.who.int/health_topics/laboratory/jelab.htm http://www.polioeradication.org/dataandmonitoring/surveillance/globalpoliolaboratorynetwork.aspx http://www.polioeradication.org/dataandmonitoring/surveillance/globalpoliolaboratorynetwork.aspx http://www.pulsenetinternational.org/networks/pages/asiapacific.aspx http://www.pulsenetinternational.org/networks/pages/canada.aspx http://www.pulsenetinternational.org/networks/pages/latinamerica.aspx http://www.aphl.org/aboutaphl/memberlabs/pages/default.aspx http://www.pasteur-international.org/ip/easysite/pasteur-international-en/institut-pasteur-international-network/the-network http://www.pasteur-international.org/ip/easysite/pasteur-international-en/institut-pasteur-international-network/the-network http://www.who.int/csr/disease/influenza/centres/en/index.html http://www.whonet.org/dnn/whonetcommunity/tabid/63/language/en-us/default.aspx http://www.whonet.org/dnn/whonetcommunity/argentina/tabid/62/language/en-us/default.aspx http://www.whonet.org/dnn/whonetcommunity/argentina/tabid/62/language/en-us/default.aspx layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts analysis of heat illness using michigan emergency department syndromic surveillance fatema mamou* and tiffany henderson michigan department of community health, lansing, mi, usa objective the purpose of this work was to conduct an enhanced analysis of heat illness during a heat wave using michigan’s emergency department syndromic surveillance system (msss) that could be provided to public health and preparedness stakeholders for situational awareness. introduction the msss, described elsewhere (1), has been in use since 2003 and records emergency department (ed) chief complaint data along with the patient’s age, gender and zip code in real time. there were 85/139 hospital eds enrolled in msss as of june 2012, capturing 77% of the annual hospital ed visits in michigan. the msss is used routinely during the influenza season for situational awareness and is monitored throughout the year for aberrations that may indicate an outbreak, emerging disease or act of bioterrorism. the system has also been used to identify heat-related illnesses during periods of extreme heat. very young children, the elderly, and people with mental illness and chronic diseases are at the highest risk of preventable heatrelated illnesses including sunburn, heat exhaustion, heat stroke and/or death (2). during a heat wave in the summer of 2012, data was reviewed on an ad hoc basis to monitor potential increases in heat-related ed visits. methods msss ed visits were queried to identify those with the primary complaints of: “heat”, “sun”, or “dehydration” including word derivatives and misspellings. the query excluded terms and misspellings such as “sunday”, “heater”, and “heatlh”. daily maximum temperatures for four major cities in michigan were tracked using measures from the national oceanic and atmospheric administration’s national weather service (3). multiple analyses were performed. for this abstract, ed data from a 10-day period of sustained above normal temperatures are presented with data from the prior 10day period used as reference. visits were categorized into 1 of 3 syndromes based on the chief complaint: sun-associated, heat-associated, and dehydration. gender, age group, and syndrome for the period of interest were compared to the reference period. heat-related visits during the period of extreme heat were also analyzed by michigan public health preparedness region. results during the period of june 28–july 7, 2012 the south and central regions of michigan sustained maximum daily temperatures surpassing 90°f with maximum temperatures at or above 100°f on at least 2 days. among the cities reviewed, a total of 9 high temperature records were set or tied during that period. the number of heat-related ed visits reported into msss increased compared to the previous period of june 18–june 27, 2012. heat-associated ed visits such as heat exhaustion and heat stroke were more frequent than the reference period, 30.0% vs. 13.7% (p<0.0001). sun-associated ed visits such as sunburn were lower compared to the reference period, 17.3% vs. 23.8% (p=0.01). dehydration complaints were elevated among those 20-29 years of age, 17.7% vs. 10.0% (p=0.01). while the proportion of ed visits due to heat-related complaints was highest in the central and northwestern areas of the state, increases were observed in all regions of michigan. on july 6, 2012 an initial analysis summary was issued via the michigan health alert network (mihan) to provide situational awareness related to a concurrent heat advisory for much of the state. by july 23, 2012 mdch issued a media release reporting this increase in heat-related ed visits. conclusions although cases used in the analysis may not represent all potential cases of heat-related illness and also may represent non-heatrelated illnesses, ed data are useful in describing trends in illness presentations over time. as the msss covers a large proportion of michigan’s population, the data from the msss can be stratified by type of heat-related injury, age group, and region, providing detailed situational awareness to public health stakeholders. this type of indepth analysis further contributes to our knowledge of heat events and allows public health to relay important information regarding the severity of the situation and information about groups at risk for illness. keywords syndromic surveillance; heat illness; extreme heat references 1. sheline kd. evaluation of the michigan emergency department syndromic surveillance system. advances in disease surveillance. 2007; 4: 265 2. cdc. extreme heat prevention guide. 2012. available from: http://emergency.cdc.gov/disasters/extremeheat/heat_guide.asp 3. national oceanic and atmospheric administration’s national weather service. available from: http://www.nws.noaa.gov/climate/ online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e139, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts smart platforms: building the app store for biosurveillance kenneth d. mandl* 1boston children’s hospital, boston, ma, usa; 2harvard medical school, boston, ma, usa objective to enable public health departments to develop “apps” to run on electronic health records (ehrs) for (1) biosurveillance and case reporting and (2) delivering alerts to the point of care. we describe a novel health information technology platform with substitutable apps constructed around core services enabling ehrs to function as iphone-like platforms. introduction health care information is a fundamental source of data for biosurveillance, yet configuring ehrs to report relevant data to health departments is technically challenging, labor intensive, and often requires custom solutions for each installation. public health agencies wishing to deliver alerts to clinicians also must engage in an endless array of one-off systems integrations. despite a $48b investment in hit, and meaningful use criteria requiring reporting to biosurveillance systems, most vendor electronic health records are architected monolithically, making modification difficult for hospitals and physician practices. an alternative approach is to reimagine ehrs as iphone-like platforms supporting substitutable apps-based functionality. substitutability is the capability inherent in a system of replacing one application with another of similar functionality. methods substitutability requires that the purchaser of an app can replace one application with another without being technically expert, without requiring re-engineering other applications that they are using, and without having to consult or require assistance of any of the vendors of previously installed or currently installed applications. apps necessarily compete with each other promoting progress and adaptability. the substitutable medical applications, reusable technologies (smart) platforms project is funded by a $15m grant from office of the national coordinator of health information technology’s strategic health it advanced research projects (sharp) program. all smart standards are open and the core software is open source. the smart project promotes substitutability through an application programming interface (api) that can be adopted as part of a “container” built around by a wide variety of hit, providing readonly access to the underlying data model and a software development toolkit to readily create apps. smart containers are hit systems, that have implemented the smart api or a portion of it. containers marshal data sources and present them consistently across the smart api. smart applications consume the api and are substitutable. results smart provides a common platform supporting an “app store for biosurveillance” as an approach to enabling one stop shopping for public health departments—to create an app once, and distribute it everywhere. further, such apps can be readily updated or created—for example, in the case of an emerging infection, an app may be designed to collect additional data at emergency department triage. or a public health department may widely distribute an app, interoperable with any smart-enabled emr, that delivers contextualized alerts when patient electronic records are opened, or through background processes. smart has sparked an ecosystem of apps developers and attracted existing health information technology platforms to adopt the smart api—including, traditional, open source, and next generation ehrs, patient-facing platforms and health information exchanges. smart-enabled platforms to date include the cerner emr, the worldvista ehr, the openmrs ehr, the i2b2 analytic platform, and the indivo x personal health record. the smart team is working with the mirth corporation, to smart-enable the healthbridge and redwood mednet health information exchanges. we have demonstrated that a single smart app can run, unmodified, in all of these environments, as long as the underlying platform collects the required data types. major ehr vendors are currently adapting the smart api for their products. conclusions the smart system enables nimble customization of any electronic health record system to create either a reporting function (outgoing communication) or an alerting function (incoming communication) establishing a technology for a robust linkage between public health and clinical environments. keywords electronic health records; biosurveillance; informatics; application programming interfaces acknowledgments this work was funded by the strategic health it advanced research projects award 90tr000101 from the office of the national coordinator of health information technology. *kenneth d. mandl e-mail: kenneth_mandl@harvard.edu online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e32, 2013 layout 1 isds annual conference proceedings 2012. this is an open access article distributed under the terms of the creative commons attributionnoncommercial 3.0 unported license (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. isds 2012 conference abstracts a binational influenza surveillance network – california/baja california esmeralda iniguez-stevens*, sarah marikos and karen ferran ewids, california department of public health, san diego, ca, usa objective to enhance cross-border surveillance for influenza-like-illness (ili) in the california/baja california (ca/bc) border region through the formation of a border binational surveillance network. introduction in response to the 2009 h1n1 pandemic, the early warning infectious disease surveillance program (ewids) office of binational border health in the california department of public health sought to strengthen outpatient ili surveillance along the ca/bc border by creating the first binational influenza surveillance network in the region. the establishment of this network was crucial for enhancing cross-border situational awareness of influenza activity, especially in a region characterized by high levels of population mobility. methods during summer of 2009, an assessment of current ili surveillance activities in the ca/bc border region was conducted. findings were utilized to guide recruitment efforts and build a cross-border surveillance network. in ca the assessment revealed that sentinel sites in the border region participating in cdc’s ilinet surveillance program were primarily pediatric or school-based clinics and that family practice patients were not equally represented. in bc the need to enhance surveillance among the private sector was identified, particularly among patients belonging to binational healthcare service plans. these plans offer care to us workforce individuals who seek medical care in bc. other needs identified included the need to enhance surveillance among underserved populations such as farm workers and tribal communities which were not currently being represented. working together with partners from both sides of the border ewids initiated efforts to address identified gaps. over a three-year period ewids recruited private and public sector clinics to participate in the network. results as a result of the assessment recruitment efforts were focused on inviting family practice clinics, private clinics, tribal health centers and clinics that provide care to underserved populations to participate in the network. these efforts led to the establishment of the california/baja california border outpatient provider ili surveillance network, which monitors syndromic and virologic influenza activity. in total ewids recruited 22 (13 in ca, 9 in bc) sentinel sites to participate; of these, 17 are family practice sites and 5 are pediatric sites. additionally, prior to the ewids enhancement local tribal health clinics were not represented in the surveillance system. ewids efforts resulted in the inclusion of 8 tribal sites in ca and 1 in bc. figure 1 shows the geographical location of network sites, which includes sites recruited by ewids post-assessment as well as preexisting sites. over the past three influenza seasons (2009-2012) ewids recruited sites have constituted 47% of all network sites. since the 2009-2010 influenza season 483,772 individuals have been screened for ili by participating sites; of these, 65.8% (n=318,295) were screened by ewids recruited sites. since the establishment of the network ewids has focused on sentinel site retention, logistical support, data collection, and dissemination of surveillance results. a weekly report summarizing syndromic and virologic activity is distributed to public health officials throughout the influenza season. conclusions the network serves as an example of a successful binational coordinated effort to establish an early warning system for enhancing situational awareness of influenza activity in a cross-border setting. next steps include conducting a formal evaluation of the existing surveillance system, enhancing specimen collection for virologic testing, and continuing to foster and build public/private partnerships. figure 1. surveillance network keywords influenza; surveillance; syndromic; virologic; binational acknowledgments we gratefully acknowledge all our border partners for their contributions and support including: border infectious disease surveillance program, imperial county public health department, county of san diego public health services epidemiology & immunization services branch, naval health research center laboratory, california department of public health center for infectious diseases, laboratorio estatal de salud publica de baja california, departamento de epidemiologia estatal baja california, and our medical partners. *esmeralda iniguez-stevens e-mail: einiguez@cdph.ca.gov online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(1):e3, 2013 android and odk based data collection framework to aid in epidemiological analysis 1 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi android and odk based data collection framework to aid in epidemiological analysis a. raja1, a. tridane2, a. gaffar1, t. lindquist 1and k. pribadi3 1. department of engineering, arizona state university, mesa, arizona, usa, 2. department of mathematical science, united arab emirates university, al ain, uae 3. renaissance sciences corporation, chandler, arizona, usa. abstract periodic collection of field data, analysis and interpretation of data are key to a good healthcare service. this data is used by the subsequent decision makers to recognize preventive measures, provide timely support to the affected and to help measure the effects of their interventions. while the resources required for good disease surveillance and proactive healthcare are available more readily in developed countries, the lack of these in developing countries may compromise the quality of service provided. this combined with the critical nature of some diseases makes this an essential issue to be addressed. taking advantage of the rapid growth of cell phone usage and related infrastructure in developed as well as developing countries, several systems have been established to address the gaps in data collection. android, being an open sourced platform, has gained considerable popularity in this aspect. open data kit is one such tool developed to aid in data collection. the aim of this paper is to present a prototype framework built using few such existing tools and technologies to address data collection for seasonal influenza, commonly referred to as the flu. keywords: android; open data kit; influenza; data collection and surveillance correspondence: a-tridane@uaeu.ac.ae copyright ©2014 the author(s) this is an open access article. authors own copyright of their articles appearing in the online journal of public health informatics. readers may copy articles without permission of the copyright owner(s), as long as the author and ojphi are acknowledged in the copy and the copy is used for educational, not-for-profit purposes. introduction public healthcare services rely on accurate and efficient surveillance of public’s health for providing proactive and timely measures to prevent and control a disease. this information is not only used to target interventions and start investigations of a disease, but also for alerting the public on possible outbreaks and guide them through essential preventive measures. the bidirectional communication allows for higher chances to control a disease [1]. the means of data collection and analysis have undergone several changes in the last few years. paper based modes of information gathering are slowly being replaced with the use of emerging technologies for better, faster and more error-free processes. health care business analytics are also growing towards the use of cloud computing due to the lower financial risks involved and the flexibility which it offers. using traditional means such as paper forms or personal digital assistants for information gathering is not only time consuming but also adds an additional cost android and odk based data collection framework to aid in epidemiological analysis 2 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi to the organization collecting the data. the widespread nature of these tasks makes them economically taxing as well. the distribution, maintenance, ease of use etc. are other factors which need to be handled. many health departments recognize the need for adapting the emerging technology for improving notifiable condition reporting (also known as case reporting – case reporting from healthcare providers to public health agencies) and public health alerting. in recent years, the center for disease control and prevention (cdc) in collaboration with the council for state and territorial epidemiologists (cste) have proposed a model for the exchange, sharing and retrieval of notifiable condition reporting from an electronic health record [1]. this suggests that electronic notifiable condition reporting may soon be feasible at larger scales. the use of mobile phones for data collection has also seen a considerable growth. adapting the mobile data collection to work with standard used in health care domain for data reporting could very well be a futuristic way of case reporting. mobile phones, including smartphones, are becoming very popular in most parts of the world. quoting an ihs isuppli wireless communications market tracker report from information and analytics provider ihs (nyse: ihs), ‘the smartphone shipments in 2013 are forecast to account for 54 percent of the total cellphone market, up from 46 percent in 2012 and 35 percent in 2011 [2]. by 2016, smartphones are expected to represent 67.4 percent of the total cellphone market’, as shown in the fig 1 below. figure 1 smartphone market share forecast by isuppli [2] with the rapid growth in the mobile industry, the capability of phones has also tremendously increased. mobile phones now have built in features to capture media, gps, share information seamlessly and have enhanced display. technologies such as bluetooth, sms, wi-fi and web are well integrated together. there has also been significant increase in the data holding capacity in these devices and their processing powers. another significant advantage is that competition and the huge market for smart mobiles has rendered these devices more affordable than laptops, computers and tablets. android, being an open source project has inspired various developers to use the api for designing need based applications. in the field of data surveillance and analysis, various applications such as pendragon forms [3], open data kit (odk) [4], epicollect [5], ecaalyx android and odk based data collection framework to aid in epidemiological analysis 3 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi [6] have been talked about and explored. open data kit in particular has exposed a few open source generic tools which can be used either individually or together [7]. this is mentioned more in detail in the framework section. the advantage of open data kit is that the tools are open source and are based on open standard interfaces, which allows us to leverage them for our needs. in this report we talk about reacap. reacap is a part of a framework designed to use the computational capability of smart phones for the process of information collection, modeling and analysis for infectious diseases. providing means for easier form design, form retrieval and storage, analysis and modeling, all using the capability and features of smartphones is demonstrated. in this report we focus on reacap – the surveillance application. in order to build a prototype application showing the advantages of this framework we chose influenza or seasonal flu as the disease to demonstrate the application. influenza, also known as flu is a contagious respiratory illness spread through the air. the severity of the disease usually varies with one season to the other depending on the type of flu virus, availability of the vaccines and how well the flu vaccine is matched to the virus. it is often confused with common cold due to the similarity between their symptoms. the disease affects thousands of individuals every year. in arizona usa alone, where the project was developed, the number of lab reported cases of influenza for the 2012-2013 season was 10304 [8]. the first section in this report covers the framework technologies used in the development of this project. the second section is the application description. it talks about the design of the application and the various processes followed in its implementation. the third section talks about the advantages and disadvantages seen in this approach. section 4 presents the summary and conclusion. framework technologies this section describes the core technologies used in the development of reacap. reacap as mentioned before is the data collection interface for a framework comprising of surveillance, analysis, forecast and collaboration, developed for monitoring and analysis of seasonal influenza. the technologies describe here provide the foundations on which reacap was built. they are described in detail below. figure 2: transformation code xml is an established standard that has been around for several years, and has reached a level of maturity that greatly enhances software applications compatibility. if fact, the power of xml is android and odk based data collection framework to aid in epidemiological analysis 4 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi that it can enhance interoperability among disparate software applications even without xml being an end goal to any of them; it can work as a middle ground [9]. without xml, any application can still communicate with another application by writing a special “transformation code” that reads the output format of the source application, and generate the equivalent input format of the “destination” application. for bi-directional communication, another set of transformation code will be needed to support the reverse direction of communication (from destination to source). with a large number of software application standards around, the number of transformation classes needed would be prohibitively large. assuming that we have n software applications written with different standards, the number of transformation classes needed for bi-directional communication would be 2 *(n (n-1)) as per figure 2 [10]. xml is the only standard format that is used as a middle ground between other software standards (see figure 3). if any software application is capable of using xml as a communication middle ground (that would still require one transformation code to xml and one from xml back to the application), we can reduce the number of transformation codes to 2n. this can be a significant reduction in complexity looking at the large number of software standards (n) we have today. furthermore, any new software standard will only need to use xml as a common ground rather than having to write transformation code to all existing standards. figure 3: xml as a common ground for this reason, we focus on using xml as a base for our approach. with the widespread versatility in mobile standards, xml will allow us to be compatible with any one of them. on the back end, additional savings exist since the data collected will be written as xml data, which is platform independent. the xml space xml itself is text based, allowing it to be human readable, without the need of any specialized software. we often refer to it as “document oriented xml”. however, greater advantages can be attained beyond that. being fully structured, xml could also be processed by software tools as a “formal document” following well-defined models [11], [12]. unlike html, xml is written using a formal structure using several document descriptions (like the xml schema, the data object model) to describe a strict document structure needed for software tools. the xml document itself is validated against these rules to ensure that the document can be parsed by software tools to correctly extract the semantics [13]. this allows developers to write several android and odk based data collection framework to aid in epidemiological analysis 5 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi xml-based tools to automatically parse and process an xml document for different needs. therefore, in the realm of xml, numerous applications have been written to transform xml document in many different ways, making it suitable to compile and run xml-based application in the same way we do any other software. xml document can work as a base, carring all necessary information and structure. it can then be transformed by parsing it using xsl transformation, and then presented in any of the known formats (presentation) on the right. marshalling and unmarshalling allows for structural compatibility between linear (serial) formats (like html, pdf, and xml itself), and parallel formats of high-level programming languages (like java, c/c++).sub-heading 1 xforms xforms is a model view controller based xml format. it was developed by the world wide web consortium (w3c) to overcome the limitations of older html forms [14]. traditional html web forms do not distinguish between the content and the presentation of a form. xforms on the other hand, is comprised of two parts, the xforms model (describing the form's purpose, logic and initial data) and the xforms user interface (describing the forms presentation). the connection between the xforms model and the xforms user interface is called the binding, and it uses a common w3c technology called xpath. xpath uses path expressions to identify nodes in an xml document. in xforms this is done by using the 'ref' or 'bind' attribute. fig 4 below describes the main components of an xform. figure 4 components of xform xforms allow for flexible presentation options. the xforms model is capable of working with variety of standard or proprietary user interfaces in order to render the form. the presentation of an xform can be interpreted differently by different interfaces. for instance, based on the style sheet used by a browser, the interpretation of xforms by a mobile browser and web browser would be different. controls in a cell phone are easier when described by lists and menus as opposed to traditional pop-up choice boxes. xforms also allow for form validation and data restraints. a particular field could be defined read only or the restraints in data entered would android and odk based data collection framework to aid in epidemiological analysis 6 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi prevent erroneous inputs. this acts a light validation mechanism before the data is sent to the data manager/database [14]. xforms have been demonstrated for usage in many different settings. their use has been explored in web services, xforms processors and even for linking data models to forms in insurance industry. in the healthcare domain, the specification is still underutilized but is starting to be recognized for its advantages [1]. researchers in australia used xforms for developments of decision system support. in germany, developers implemented an information system to maintain details of prescription drug formulary [1]. openmrs is an example of the usage of xforms in clinical and public health systems. to read the xforms and present the form document to the user, xform clients are used. in this project, the xform client we are using is javarosa [15]. javarosa is a mobile based xform client. due to the limited capability of cell phones as compared to desktops/laptops, javarosa only supports a subset of xforms. additional customizations, specific to mobile use, have also been introduced. this will be covered in more detail in the section below. javarosa javarosa is an xforms client developed for mobile phones. it is written in j2me. it was developed as a product of the openrosa consortium. it is basically a mobile application platform which can be tailored by developers to suit their needs. it contains an xform engine at its core. the xform engine is responsible for reading the form elements, use the binding specified in xform to interpret the elements and present the element to the user [15]. the logic behind the nature of the element and how it is presented to the user is determined by the xform engine. mobile devices differ greatly from conventional desktops in their computational power and their user interface. they are limited in power and have enhanced ui. this prompted the adaptation of javarosa to tailor their xform support to the mobile market. they support only a subset of xform specification and in some cases support a feature only in a particular way. javarosa has also introduced some additional form features which enhances the xform experience on mobiles. this includes additional features as well as redefining preexisting xform features. one of the core components on which reacap was built, open data kit collect, utilizes javarosa for form logic and form processing. designing a form for reacap requires a good understanding of the underlying javarosa specifications. forms can be developed by writing raw xml or by using a form designer such as odk build [7], purcforms [11], xls2xform [16]. in the current implementation of reacap, forms were developed using xls2xform. these will be talked about in more detail below open data kit (odk) open data kit is an open source suite of tools which was designed to help users build information services for developing nations. odk started as a google.org sponsored sabbatical project and was continued back at the university of washington seattle. it currently supports various tools, most notable of which are odk build, odk collect and odk aggregate. the tools are designed android and odk based data collection framework to aid in epidemiological analysis 7 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi to be used independently or together. being built on existing open standards, they enable users to build services to collect and distribute information in places where user limitations or limitations on infrastructure has long posed problems [4]. for the design of reacap, we evaluated the a few of the odk tools for compatibility. odk build [4] is a drag and drop web based form designer. even though odk build is a developing application, it was best suited for designing simple forms. in order to allow flexibility in our influenza survey form, we decided to use odk build only as a starting point in the design of our form and allow for design of more complex forms. odk collect is an android based mobile client which acts as the interface between the user and the underlying form. collect takes the xform logic of the form and displays it to the user in a one prompt at a time format. javarosa provides the form processing and form logic which odk uses. in disconnected mode, odk collect stores the application logic and the form data on the phone in a xml format and as binary files for media. the user can choose to synchronize with a server as required. files are sent using standard http post to any open rosa compatible server [4]. since reacap is a prototype application developed to aid in data collection for influenza, using odk collect to design the android client seemed appropriate. simple, ease of navigate, ease of comprehension and thoroughness were some of the characteristics which we were looking at for reacap. odk collect was a good match. the form processing logic, its display and offline storage were some of the features of odk collect which was used in reacap. odk is also supported by an open source community that has contributed training documents, localization support as well as additional tools. these advantages made odk collect a suitable choice for this project. epicollect epicollect is a free, open source, data collection tool developed by researchers in the imperial college at london and the university of bath in uk. it allows an mobile user to submit geotagged forms with or without images to central server located within www.spatialepidemiology.net. the server, allows the mapping and visualization (to google maps or earth) and analysis of the data. the data can also be downloaded or viewed on the phone using google maps [5]. fig 5 below captures one of the use cases of epicollect. data collected by registered users is sent to a central database. data can then be viewed on google maps/earth or on phones. epicollect also allows the user to filter the data as shown in the figure. android and odk based data collection framework to aid in epidemiological analysis 8 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi figure 5 data collection, collation and visualisation framework using epicollect and www.spatialepidemiology.net [5] epicollect provides a generic framework for point data collection and analysis, both for android and ios. the analysis is sorely done on the server/visualization platform and has to be communicated back to the users. while this application can be widely adapted for simple data collection and viewing, it lacks the engine to process complex forms which was seen in odk. the form interface presented to the users is made to suit the needs of informed data collection agents. odk presents a more intuitive form suitable for easier use. these factors led to the preference of odk over epicollect. dropbox a central server or database as shown in fig 6, having the ability to store information securely and reliably is of prime importance in a multi-client application. this allows the clients to synchronize information more easily and provide a storage space which is limited in mobiles. availability of data from all clients in one place also aids in better analysis and decision making. the restriction of access based on privilege is also a good feature to have. one of the disadvantages of having a standalone private server is the cost of maintaining the server. this usually plays a huge role in the operational costs. the question of reliability and security also exist. the need to keep with emerging technologies, constant updates, security checks, maintaining synchronization between users are other factors due to which the popularity of cloud computing is on the rise [17]. cloud computing allows the enabling of convenient access to a shared pool of computing resources, available on demand. android and odk based data collection framework to aid in epidemiological analysis 9 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi figure 6 depiction of a centralized global server for a variety of devices they require minimum management effort or service provider information. in huge organizations, the use of cloud computing leads to much lower financial risks as well. the following table i illustrates some of the pros and cons of cloud computing. table i. pros and cons of cloud computing pros cons scalabiliy and cost lock-in encapsulated change management reliability next generation architectures lack of control choice and agility security dropbox is a cloud storage service provided to store and share your data among many applications. it provides inbuilt encryption security and access restrictions. the api allows the user to build the features of dropbox directly into a mobile application or a desktop application. it is compatible with windows, mac, linux, iphone, ipad, blackberry, and android devices. the api provides methods to read and write from dropbox securely, any changes made can be synchronized back to shared devices. other notable features include simple sharing, search, and restoring files to past revisions [18]. in the scope of this project, dropbox serves two purposes. it acts as the storage medium for the information collected by users using reacap. all the information is stored in a format which would make the retrieval and analysis of data more efficient. it is also used to store information which is the output of the reaview engine, to enable viewing the data gathered from reacap across multiple users. the synchronization feature of dropbox ensures that with the availability of network, all users will be notified of the availability of new information. android and odk based data collection framework to aid in epidemiological analysis 10 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi epiml epiml is a new xml based document interchange protocol which was developed on the area project. epiml is being designed to allow data exchange between area apps and mobile devices. epiml is also the protocol to upload/download data to reacloud. data gateways can be developed to translate epiml data to health level 7 (hl7) protocol allowing data interchange with mhs such as the navy marine corps epidata center and other health databases. epiml is the core enabler of the area systems to interchange input data, configurations, and output data allowing for full collaborations between area users and data/analysis reporting to area cloud servers. application description reacap, an information capture and survey application, is a part of overall project named area which is aimed to research the use of mobile applications for health surveillance, data analysis and forecasting. applications for rapid epidemiological analysis, also know an area, were targeted to study the feasibility of the using mobile devices for this purpose. mobile devices, smartphones in particular, have gained huge popularity in the last few years. they have become more user programmable, allowing users to mould mobile devices to their taste. they are now capable of capturing media, have inbuilt gps capabilities, and provide numerous means of sharing information. communication modes amongst devices include wi-fi, bluetooth, sms, 3g, touch and so on. these make smartphones a sought after choice for use as field instruments. area apps consist of 5 main components. reacap, the focus of this paper, is the surveillance app for collecting field information of the patients. it is built for android and uses open data kit's collect as its base. reacap allows the user to download pre built forms from the server and display them to the user. users can collect geospatial coordinates, photographs, video, audio, and any number of structured data types as their inputs. the forms can be saved at any stage and on completion, allow the user to submit the form to the server (reacloud). the other components of area include reaview, reamodel, reacould and reaconfig. reacap was developed to work in collaboration with these components. reaview is the platform to view the analysis and forecast done on the information collected. reamodel is the forecast engine available as an application on the smartphone. reaconfig is the mobile and web based configuration tool which allows the user to design forms which will then be used in reacap. the final component of area, reacloud, is the cloud based server which acts as the core to all the other applications. epiml is the data interchange format designed to talk between all these components. the output from reacap is in the epiml format. this data exchange format has the ability to contain all information required for the forms and also the modeling and viewing of the information collected. this information is stored in reacloud. reacloud also contains the forms developed by the users which are sent to reacap on request. as of the current implementation, the other components of area use the information collected from reacap through the reacloud. fig 7 shows the current peripherals of reacap. android and odk based data collection framework to aid in epidemiological analysis 11 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi figure 7 current peripherals of reacap the intent of reacap is to enable the collection of information for any canonical disease. a prototype using influenza (seasonal flu) was built to demonstrate this. the scope of this project involved studying influenza to determine the information to be collected. this information was then translated into a format which was suitable to be read by reacap. javarosa complaint xforms were used for this purpose. the forms were stored in the server (dropbox). on request by a reacap user, the forms were downloaded to reacap. the user could then fill the forms offline and send the forms back in epiml format to the server. the other area components use this information for their functions. fig 8 depicts the process followed. the sections below describe each of the components required for this project in detail. figure 8 processes involved in the development of reacap gathering information for form definition influenza was chosen to demonstrate the need for simple data surveillance and analysis in our case. influenza or seasonal flu is an airborne disease whose most common symptoms consist of chills, fever, sore throat, muscle pains, severe headache, coughing and fatigue [19]. it is often confused with other influenza like diseases such as common cold but influenza is more severe and is caused by a different kind of virus. the numbers of people affected vary depending on season and the severity depends upon the circulating influenza types and subtypes and existing immunity in the community. the survey below from the arizona department of health services show the number of influenza cases by season and age group in arizona alone. android and odk based data collection framework to aid in epidemiological analysis 12 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi table ii. age group of reported influenza cases, 2010-2011 through 2012-2013 seasons [8] in order to design a form to gather information about influenza, the following parameters were considered. • what are the most common symptoms? • how does the disease spread? what kind of environmental conditional facilitate the survival of the virus? • what makes a person more susceptible for influenza related complications? • what kind of information do we need in order for us to do preventive analysis i.e. analyze the information available and use it for precautionary measures. e.g. the influenza has an average of 2 days incubation period and virus shedding, depending on the age of person, vary from one day before symptoms through 6-11 days after the symptoms for an adult to several days before symptoms for children and can be infectious up to two weeks. • what clinical conditions are available for necessary tests in the vicinity? two types of users were considered. first a health care professional. these people are trained medical professionals well versed with the disease and are capable of making note of additional information which can help provide a better analysis (fig 9). information such as the requirement for the patient to seek medical assistance or the clinical tests which would aid the diagnosis can be suggested by them. the second use case is for anyone to use the form for everyday analysis (fig 8). an example of the two use cases are shown below figure 9 use case individual android and odk based data collection framework to aid in epidemiological analysis 13 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi figure 10 use case health care professional table iii below depicts the form contents which were determined based on our analysis. it includes information on how the form is presented to the user as well as information on conditional forwarding. depending on the type of user and the previous inputs the next set of information to be displayed is determined. table iii. influenza form flow logic information screen number screen information summary screen contents next screen patient professional 1 information to determine who is using the reacap application 3 2 2 login screen for the health care professional na if login was successful – 10 android and odk based data collection framework to aid in epidemiological analysis 14 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi 3 basic details about the patient. note: location can be recorded using gps. in case of no network, it will have to be entered manually 4 (a patient id is generated at this point ) na 4 to capture fever if yes 6 no 5 i don't know 7 na 5 cough/sore throat if yes 8 no 9 na 6 cough/sore throat 8 na 7 sweating, shiver, chills if yes 6 no 9 na android and odk based data collection framework to aid in epidemiological analysis 15 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi 8 to make a note of how long the patient has been having the symptoms 9 na 9 final screen na na 10 locality information na 11 11 patient information na 12 android and odk based data collection framework to aid in epidemiological analysis 16 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi 12 patient symptoms na if fever is yes and any of the rest are yes 13 if fever is a 'no' 9 13 epidemiologic al inputs na 14 android and odk based data collection framework to aid in epidemiological analysis 17 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi 14 determine tests na 9 (if from screen 14, we determine that the patient requires diagnostic tests, refer to the nearest health care facility for the required/ appropriate influenza diagnostic tests) the next section describes the conversion of this information into a suitable format which can be read by reacap. defining the influenza form using xforms xforms as mentioned earlier is a model to represent form data using xml. but the xforms specification is long and complex. to have an engine running to read and translate xforms would require a lot of memory and cpu resources. this is usually not available and not sought after when designing mobile applications. javarosa is the mobile client used in this project for xforms. it is tailored to run on devices with limited computational capability. it performs the task of rendering the form to the user. there are numerous tools such as purcforms designer, odk build, vellum, kobo etc which are available which help create xforms that work on javarosa platform. in this project, we have used xls2xform to help create our xform. xls2xform is a tool which simplifies the creation of xforms by letting us design the form with microsoft excel and then converting this to a javarosa compatible xform on their web based tool [16]. the working of xls2xform tool is as follows the excel workbook contains two worksheets survey and choices. the survey describes the contents and the structure of the xform. control structures such as groups or loops are specifies in this sheet as well. the questions which need to be posed to the user, related media, and how it is resented is defined in the survey sheet. android and odk based data collection framework to aid in epidemiological analysis 18 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi the choices worksheet is used to define the choices for the multiple choice questions. a row represents an entry for a multiple choice. choices are grouped be ‘list name’ column in table vii and the corresponding entries in the ‘name’ column are displayed to the user. this design allows the user to reuse the same set of multiple choice options (specified by list name). the elements (columns) of the worksheets need to be maintained in order for the validity of the xform. certain columns are mandatory. in addition, the worksheet contains optional columns which allow the user to specify constraints for each row. for example, type, name and label entries are mandatory columns in the worksheet. but other columns entries such as image, constraint etc need not be specified at all times. the order of these columns is irrelevant. optional columns could be left out if not required. blank rows are not processed. another useful feature is that the xls formatting is ignored while processing the sheet. user could highlight the entries to make it more readable but this would not affect the creation of xforms. some examples from the designing of influenza form are shown below metadata at the beginning of the form, we collect information in the background. this metadata includes the start time of the survey, the device id and the day of the survey (table iv). table iv. example of metadata type name label start start today day deviceid id branching the user type selected by the mobile user is stored in the tag as either • patient • professional based on the value in the tag, the locality information is displayed. this is done by using the relevant column in the xls form as shown below. note the highlighted section. the locality information is grouped and the constraint is applied on the entire group. repeating a particular set of questions based on previous answer at many instances, the need to repeat a particular set of questions arises. if a person has taken many prior tests and we need to record details of all of them, we can use the repeat feature of xlsform. this is shown in table v. table v. example of branching based on condition type name label hint constra int constraint_m essage relevant begin group locality_i nfo locality information ${professi on}='profe ssional' android and odk based data collection framework to aid in epidemiological analysis 19 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi select one from yes_no detected has infection been detected? begin group infection _info infection data ${detected }='yes' decimal rate infection rate enter percentage of people infected select one from inf_types type type detected choose the influenza type select one from infection_t ype infection prevelent infections end group begin group env_info environment information text food food enter comments on the food (dietary habits meat?/vegetari an?, livestock condition) text water water enter comments on the water in the locality (hygiene, supply source etc) end group end group android and odk based data collection framework to aid in epidemiological analysis 20 online journal of public health informatics * issn 1947-2579 * http://ojphi.org * 5(3):e228, 2014 ojphi table vi. example of repetition based on condition type name label hint constraint constraint_ message relevant begin group prior_tests prior tests ${fever} ='yes' select one from yes_no test_taken any prior influenza tests taken in the last 3-4 days? begin repeat test test ${test_ta ken}='ye s' begin group test_details test details text test_name name of the test text test_result results end group end repeat end group image names can be provided in the excel to specify which images to associate with a particular screen. these images must be stored in the corresponding